locus-tag	class	description
DDE74_RS00010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DDE74_RS00050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DDE74_RS00090	COG0492	ferredoxin-NADP+ reductase activity
DDE74_RS00115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DDE74_RS00140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDE74_RS00160	COG1131	(ABC) transporter
DDE74_RS00175	COG0585	pseudouridine synthase activity
DDE74_RS00190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DDE74_RS00260	COG0105	UTP biosynthetic process
DDE74_RS00330	COG1280	lysine exporter protein (LysE YggA)
DDE74_RS00350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDE74_RS00365	COG0542	response to heat
DDE74_RS00450	COG2814	Major facilitator Superfamily
DDE74_RS00520	COG2897	thiosulfate sulfurtransferase activity
DDE74_RS00530	COG0626	cystathionine gamma-synthase activity
DDE74_RS00545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDE74_RS00560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDE74_RS00580	COG0454	-acetyltransferase
DDE74_RS00585	COG1335	isochorismatase
DDE74_RS00590	COG0583	DNA-binding transcription factor activity
DDE74_RS00610	COG0405	Gamma-glutamyltransferase
DDE74_RS00620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDE74_RS00620	COG0515	serine threonine protein kinase
DDE74_RS00645	COG5504	Zn-dependent protease
DDE74_RS00650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DDE74_RS00660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDE74_RS00690	COG0529	Catalyzes the synthesis of activated sulfate
DDE74_RS00740	COG4172	Belongs to the ABC transporter superfamily
DDE74_RS00745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDE74_RS00770	COG4948	Mandelate Racemase Muconate Lactonizing
DDE74_RS00785	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDE74_RS00815	COG0009	L-threonylcarbamoyladenylate synthase
DDE74_RS00845	COG3647	Membrane
DDE74_RS00890	COG1136	(ABC) transporter
DDE74_RS00890	COG0577	efflux transmembrane transporter activity
DDE74_RS00900	COG1653	transport
DDE74_RS00905	COG0366	Alpha amylase catalytic
DDE74_RS00910	COG1653	transport
DDE74_RS00915	COG1175	transmembrane transport
DDE74_RS00920	COG0395	ABC-type sugar transport system, permease component
DDE74_RS00940	COG1349	DNA-binding transcription factor activity
DDE74_RS00965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DDE74_RS00970	COG2226	methyltransferase
DDE74_RS00985	COG2267	carboxylic ester hydrolase activity
DDE74_RS01020	COG1271	oxidase subunit
DDE74_RS01035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DDE74_RS01040	COG1113	amino acid transport
DDE74_RS01050	COG2130	NADP-dependent
DDE74_RS01065	COG2130	NADP-dependent
DDE74_RS01090	COG0402	S-adenosylhomocysteine deaminase activity
DDE74_RS01110	COG1022	Amp-dependent synthetase and ligase
DDE74_RS01160	COG2885	chlorophyll binding
DDE74_RS01210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DDE74_RS01245	COG3387	PFAM Glycoside hydrolase 15-related
DDE74_RS01265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDE74_RS01275	COG0456	acetyltransferase
DDE74_RS01275	COG1846	Transcriptional regulator
DDE74_RS01325	COG0181	hydroxymethylbilane synthase activity
DDE74_RS01375	COG1794	racemase activity, acting on amino acids and derivatives
DDE74_RS01415	COG1073	alpha beta
DDE74_RS01450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DDE74_RS01475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DDE74_RS01485	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DDE74_RS01505	COG0517	IMP dehydrogenase activity
DDE74_RS01550	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DDE74_RS01560	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DDE74_RS01575	COG0543	2 iron, 2 sulfur cluster binding
DDE74_RS01615	COG2239	Acts as a magnesium transporter
DDE74_RS01625	COG0516	GMP reductase activity
DDE74_RS01625	COG0517	IMP dehydrogenase activity
DDE74_RS01630	COG0589	response to stress
DDE74_RS01635	COG0574	Belongs to the PEP-utilizing enzyme family
DDE74_RS01635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDE74_RS01640	COG2239	Acts as a magnesium transporter
DDE74_RS01645	COG0528	UMP kinase activity
DDE74_RS01680	COG2239	Acts as a magnesium transporter
DDE74_RS01720	COG0598	Magnesium transport protein CorA
DDE74_RS01765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DDE74_RS01815	COG0531	amino acid
DDE74_RS01850	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DDE74_RS01855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DDE74_RS01860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DDE74_RS01880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DDE74_RS01905	COG3757	hydrolase, family 25
DDE74_RS01905	COG3409	Peptidoglycan-binding domain 1 protein
DDE74_RS01925	COG1404	Belongs to the peptidase S8 family
DDE74_RS01965	COG0301	tRNA thio-modification
DDE74_RS01995	COG1051	belongs to the nudix hydrolase family
DDE74_RS02010	COG1024	Enoyl-CoA hydratase
DDE74_RS02015	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS02050	COG0574	Belongs to the PEP-utilizing enzyme family
DDE74_RS02050	COG3848	Pyruvate phosphate dikinase
DDE74_RS02075	COG0778	Nitroreductase
DDE74_RS02080	COG1309	transcriptional regulator
DDE74_RS02090	COG0640	Transcriptional regulator
DDE74_RS02095	COG0798	PFAM Bile acid sodium symporter
DDE74_RS02100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DDE74_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS02175	COG1113	amino acid transport
DDE74_RS02180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDE74_RS02180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDE74_RS02210	COG0789	Transcriptional regulator
DDE74_RS02220	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DDE74_RS02225	COG1126	abc transporter atp-binding protein
DDE74_RS02235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS02280	COG0513	Belongs to the DEAD box helicase family
DDE74_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS02310	COG1132	(ABC) transporter
DDE74_RS02325	COG2135	peptidase activity
DDE74_RS02345	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DDE74_RS02355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDE74_RS02395	COG4608	Belongs to the ABC transporter superfamily
DDE74_RS02415	COG1819	glycosyl
DDE74_RS02485	COG3655	Transcriptional regulator
DDE74_RS02515	COG4585	Histidine kinase
DDE74_RS02520	COG2197	response regulator
DDE74_RS02580	COG2226	methyltransferase
DDE74_RS02600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDE74_RS02715	COG0277	FAD linked oxidase domain protein
DDE74_RS02730	COG1129	ABC transporter
DDE74_RS02735	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDE74_RS02745	COG3391	amine dehydrogenase activity
DDE74_RS02760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDE74_RS02820	COG1819	glycosyl
DDE74_RS02825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS02840	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DDE74_RS02845	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDE74_RS02855	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDE74_RS02860	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DDE74_RS02880	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DDE74_RS02905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDE74_RS02910	COG0500	methyltransferase
DDE74_RS02915	COG1819	glycosyl
DDE74_RS02920	COG1278	Cold shock
DDE74_RS02925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDE74_RS02940	COG1819	glycosyl
DDE74_RS03025	COG0604	alcohol dehydrogenase
DDE74_RS03025	COG3321	synthase
DDE74_RS03075	COG2197	response regulator
DDE74_RS03105	COG2130	NADP-dependent
DDE74_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS03115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS03115	COG4221	oxidoreductase activity
DDE74_RS03115	COG3321	synthase
DDE74_RS03120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDE74_RS03120	COG3321	synthase
DDE74_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS03120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDE74_RS03120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS03125	COG4221	oxidoreductase activity
DDE74_RS03125	COG3321	synthase
DDE74_RS03125	COG0300	oxidoreductase activity
DDE74_RS03125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDE74_RS03130	COG0367	asparagine synthase
DDE74_RS03145	COG3903	Transcriptional regulator
DDE74_RS03145	COG3629	intracellular signal transduction
DDE74_RS03150	COG0583	DNA-binding transcription factor activity
DDE74_RS03185	COG0047	phosphoribosylformylglycinamidine synthase activity
DDE74_RS03195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDE74_RS03210	COG0697	spore germination
DDE74_RS03325	COG0384	phenazine biosynthesis protein PhzF
DDE74_RS03340	COG1121	(ABC) transporter
DDE74_RS03355	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS03360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDE74_RS03365	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS03405	COG0516	GMP reductase activity
DDE74_RS03405	COG0517	IMP dehydrogenase activity
DDE74_RS03420	COG0516	GMP reductase activity
DDE74_RS03420	COG0517	IMP dehydrogenase activity
DDE74_RS03430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DDE74_RS03435	COG1278	Cold shock
DDE74_RS03440	COG0513	Belongs to the DEAD box helicase family
DDE74_RS03465	COG4221	oxidoreductase activity
DDE74_RS03485	COG3424	synthase
DDE74_RS03490	COG0443	Heat shock 70 kDa protein
DDE74_RS03495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DDE74_RS03510	COG2197	response regulator
DDE74_RS03515	COG1132	(ABC) transporter
DDE74_RS03520	COG1132	(ABC) transporter
DDE74_RS03530	COG0515	serine threonine protein kinase
DDE74_RS03575	COG1414	Transcriptional regulator
DDE74_RS03580	COG0179	Fumarylacetoacetate (FAA) hydrolase
DDE74_RS03610	COG1968	undecaprenyl-diphosphatase activity
DDE74_RS03635	COG1113	amino acid transport
DDE74_RS03675	COG4213	ABC transporter substrate-binding protein
DDE74_RS03685	COG4214	carbohydrate transport
DDE74_RS03710	COG2326	polyphosphate kinase activity
DDE74_RS03735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDE74_RS03745	COG1366	Belongs to the anti-sigma-factor antagonist family
DDE74_RS03755	COG0006	proline dipeptidase activity
DDE74_RS03780	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS03790	COG1024	Enoyl-CoA hydratase
DDE74_RS03810	COG0183	Belongs to the thiolase family
DDE74_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS03820	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS03850	COG0542	response to heat
DDE74_RS03870	COG1864	DNA RNA non-specific endonuclease
DDE74_RS03870	COG3591	Belongs to the peptidase S1B family
DDE74_RS03905	COG3415	Transposase
DDE74_RS03905	COG2801	Transposase and inactivated derivatives
DDE74_RS03910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DDE74_RS03920	COG3290	protein histidine kinase activity
DDE74_RS03925	COG4565	transcriptional regulatory protein
DDE74_RS03935	COG2186	Transcriptional regulator
DDE74_RS03940	COG1113	amino acid transport
DDE74_RS03970	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS04010	COG0640	Transcriptional regulator
DDE74_RS04025	COG1556	Lactate utilization protein
DDE74_RS04030	COG1139	Iron-sulfur cluster binding protein
DDE74_RS04035	COG0247	lactate metabolic process
DDE74_RS04040	COG1620	l-lactate permease
DDE74_RS04055	COG1595	DNA-templated transcription, initiation
DDE74_RS04080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDE74_RS04090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDE74_RS04105	COG1414	Transcriptional regulator
DDE74_RS04115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDE74_RS04125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DDE74_RS04145	COG2268	Band 7 protein
DDE74_RS04150	COG1595	DNA-templated transcription, initiation
DDE74_RS04155	COG1902	pentaerythritol trinitrate reductase activity
DDE74_RS04185	COG3135	benzoate transporter
DDE74_RS04190	COG0626	cystathionine gamma-synthase activity
DDE74_RS04200	COG2423	ornithine cyclodeaminase activity
DDE74_RS04275	COG1120	ATPase activity
DDE74_RS04280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS04315	COG2274	protein secretion by the type I secretion system
DDE74_RS04330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DDE74_RS04330	COG1796	DNA polymerase
DDE74_RS04345	COG0583	DNA-binding transcription factor activity
DDE74_RS04350	COG0156	8-amino-7-oxononanoate synthase activity
DDE74_RS04355	COG1063	alcohol dehydrogenase
DDE74_RS04420	COG0745	RESPONSE REGULATOR receiver
DDE74_RS04425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDE74_RS04425	COG1024	Enoyl-CoA hydratase
DDE74_RS04440	COG0477	Major facilitator Superfamily
DDE74_RS04480	COG3585	molybdate ion transport
DDE74_RS04545	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DDE74_RS04575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDE74_RS04600	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS04665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDE74_RS04670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDE74_RS04700	COG0386	Belongs to the glutathione peroxidase family
DDE74_RS04720	COG1132	(ABC) transporter
DDE74_RS04730	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DDE74_RS04750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DDE74_RS04755	COG0667	Aldo Keto reductase
DDE74_RS04790	COG2226	methyltransferase
DDE74_RS04810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DDE74_RS04815	COG1509	lysine 2,3-aminomutase activity
DDE74_RS04825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DDE74_RS04835	COG0745	RESPONSE REGULATOR receiver
DDE74_RS04860	COG0745	RESPONSE REGULATOR receiver
DDE74_RS04865	COG5002	protein histidine kinase activity
DDE74_RS04885	COG0363	glucosamine-6-phosphate deaminase activity
DDE74_RS04890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DDE74_RS04900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DDE74_RS04940	COG3387	PFAM Glycoside hydrolase 15-related
DDE74_RS04945	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS04960	COG2017	converts alpha-aldose to the beta-anomer
DDE74_RS04995	COG0659	secondary active sulfate transmembrane transporter activity
DDE74_RS05025	COG2382	esterase
DDE74_RS05035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS05040	COG1535	isochorismatase
DDE74_RS05040	COG3433	isochorismatase activity
DDE74_RS05045	COG3433	isochorismatase activity
DDE74_RS05045	COG1535	isochorismatase
DDE74_RS05050	COG1021	2,3-dihydroxybenzoate-AMP ligase
DDE74_RS05055	COG1169	isochorismate synthase
DDE74_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS05070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS05075	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS05080	COG1120	ATPase activity
DDE74_RS05095	COG4585	Histidine kinase
DDE74_RS05115	COG2304	oxidoreductase activity
DDE74_RS05120	COG2197	response regulator
DDE74_RS05125	COG4585	Histidine kinase
DDE74_RS05180	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DDE74_RS05185	COG0154	amidase activity
DDE74_RS05205	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DDE74_RS05215	COG2124	cytochrome p450
DDE74_RS05230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS05240	COG3321	synthase
DDE74_RS05240	COG0604	alcohol dehydrogenase
DDE74_RS05250	COG0604	alcohol dehydrogenase
DDE74_RS05250	COG3321	synthase
DDE74_RS05260	COG0604	alcohol dehydrogenase
DDE74_RS05260	COG3321	synthase
DDE74_RS05265	COG3321	synthase
DDE74_RS05265	COG0604	alcohol dehydrogenase
DDE74_RS05270	COG0604	alcohol dehydrogenase
DDE74_RS05270	COG3321	synthase
DDE74_RS05285	COG2197	response regulator
DDE74_RS05300	COG2197	response regulator
DDE74_RS05305	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS05310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDE74_RS05355	COG0586	Pfam SNARE associated Golgi protein
DDE74_RS05360	COG3963	phosphatidate phosphatase activity
DDE74_RS05375	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS05380	COG0825	malonyl-CoA metabolic process
DDE74_RS05380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DDE74_RS05385	COG0583	DNA-binding transcription factor activity
DDE74_RS05390	COG0697	spore germination
DDE74_RS05430	COG1695	Transcriptional regulator
DDE74_RS05465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDE74_RS05465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDE74_RS05475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DDE74_RS05495	COG1716	ATPase activity
DDE74_RS05515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DDE74_RS05545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDE74_RS05555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DDE74_RS05565	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DDE74_RS05570	COG1177	transmembrane transport
DDE74_RS05575	COG1176	ABC-type spermidine putrescine transport system, permease component I
DDE74_RS05580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DDE74_RS05585	COG3842	ATPase activity
DDE74_RS05595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DDE74_RS05600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDE74_RS05615	COG0596	Alpha beta hydrolase
DDE74_RS05650	COG2146	nitrite reductase [NAD(P)H] activity
DDE74_RS05680	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DDE74_RS05700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DDE74_RS05705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DDE74_RS05710	COG1984	allophanate hydrolase subunit 2
DDE74_RS05725	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS05840	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS05850	COG2070	2-Nitropropane dioxygenase
DDE74_RS05865	COG0515	serine threonine protein kinase
DDE74_RS05875	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS05895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS05900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS05905	COG1120	ATPase activity
DDE74_RS05910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DDE74_RS05915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DDE74_RS05925	COG2814	Major facilitator Superfamily
DDE74_RS05930	COG4264	IucA IucC family
DDE74_RS05950	COG0243	molybdopterin cofactor binding
DDE74_RS05980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DDE74_RS06090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DDE74_RS06095	COG1280	lysine exporter protein (LysE YggA)
DDE74_RS06115	COG3634	alkyl hydroperoxide reductase activity
DDE74_RS06145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DDE74_RS06160	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS06170	COG2376	Dihydroxyacetone kinase
DDE74_RS06175	COG1461	Dihydroxyacetone kinase
DDE74_RS06205	COG1349	DNA-binding transcription factor activity
DDE74_RS06220	COG0395	ABC-type sugar transport system, permease component
DDE74_RS06240	COG1793	dna ligase
DDE74_RS06245	COG0277	FAD linked oxidase domain protein
DDE74_RS06250	COG3224	Antibiotic biosynthesis monooxygenase
DDE74_RS06255	COG0590	tRNA wobble adenosine to inosine editing
DDE74_RS06270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DDE74_RS06275	COG0647	UMP catabolic process
DDE74_RS06340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDE74_RS06350	COG0667	Aldo Keto reductase
DDE74_RS06360	COG0367	asparagine synthase
DDE74_RS06365	COG0010	Belongs to the arginase family
DDE74_RS06370	COG2175	clavaminate synthase activity
DDE74_RS06380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDE74_RS06390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDE74_RS06395	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDE74_RS06400	COG2814	Major facilitator Superfamily
DDE74_RS06445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DDE74_RS06450	COG0463	Glycosyl transferase, family 2
DDE74_RS06465	COG3217	Mosc domain protein beta barrel domain protein
DDE74_RS06465	COG0633	Ferredoxin
DDE74_RS06495	COG1349	DNA-binding transcription factor activity
DDE74_RS06550	COG1940	carbohydrate kinase activity
DDE74_RS06555	COG2223	nitrite transmembrane transporter activity
DDE74_RS06565	COG2197	response regulator
DDE74_RS06570	COG4585	Histidine kinase
DDE74_RS06575	COG0445	tRNA wobble uridine modification
DDE74_RS06585	COG0494	nUDIX hydrolase
DDE74_RS06590	COG0395	ABC-type sugar transport system, permease component
DDE74_RS06595	COG1175	transmembrane transport
DDE74_RS06605	COG3345	alpha-galactosidase
DDE74_RS06630	COG2318	DinB family
DDE74_RS06635	COG3415	Transposase
DDE74_RS06635	COG2801	Transposase and inactivated derivatives
DDE74_RS06650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DDE74_RS06710	COG0584	glycerophosphoryl diester phosphodiesterase
DDE74_RS06720	COG0765	amino acid transport
DDE74_RS06730	COG0667	Aldo Keto reductase
DDE74_RS06735	COG0456	acetyltransferase
DDE74_RS06755	COG0671	phosphoesterase, PA-phosphatase related
DDE74_RS06785	COG2197	response regulator
DDE74_RS06795	COG1222	aaa ATPase
DDE74_RS06805	COG3629	intracellular signal transduction
DDE74_RS06805	COG3903	Transcriptional regulator
DDE74_RS06885	COG1231	oxidoreductase activity
DDE74_RS06925	COG2271	Major facilitator Superfamily
DDE74_RS06930	COG2197	response regulator
DDE74_RS06935	COG4585	Histidine kinase
DDE74_RS06945	COG1131	(ABC) transporter
DDE74_RS06955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DDE74_RS06960	COG0745	RESPONSE REGULATOR receiver
DDE74_RS06965	COG2205	protein histidine kinase activity
DDE74_RS07010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DDE74_RS07015	COG0140	phosphoribosyl-ATP diphosphatase activity
DDE74_RS07020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DDE74_RS07025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDE74_RS07025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDE74_RS07030	COG3201	nicotinamide mononucleotide transporter
DDE74_RS07045	COG1090	epimerase
DDE74_RS07050	COG1940	carbohydrate kinase activity
DDE74_RS07050	COG1846	Transcriptional regulator
DDE74_RS07055	COG2223	nitrite transmembrane transporter activity
DDE74_RS07065	COG1335	isochorismatase
DDE74_RS07085	COG2233	PERMEase
DDE74_RS07110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDE74_RS07135	COG0531	amino acid
DDE74_RS07155	COG2390	Transcriptional regulator
DDE74_RS07160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DDE74_RS07170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDE74_RS07185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DDE74_RS07210	COG0284	orotidine-5'-phosphate decarboxylase activity
DDE74_RS07215	COG0167	dihydroorotate dehydrogenase activity
DDE74_RS07220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DDE74_RS07225	COG0505	Belongs to the CarA family
DDE74_RS07235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDE74_RS07240	COG0540	Belongs to the ATCase OTCase family
DDE74_RS07245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DDE74_RS07255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DDE74_RS07260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DDE74_RS07265	COG0006	proline dipeptidase activity
DDE74_RS07275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DDE74_RS07280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DDE74_RS07285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DDE74_RS07290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DDE74_RS07295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DDE74_RS07310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DDE74_RS07315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DDE74_RS07335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DDE74_RS07355	COG0124	histidyl-tRNA synthetase
DDE74_RS07365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DDE74_RS07370	COG1196	nuclear chromosome segregation
DDE74_RS07375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DDE74_RS07380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DDE74_RS07385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDE74_RS07390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDE74_RS07400	COG2255	four-way junction helicase activity
DDE74_RS07405	COG0632	four-way junction helicase activity
DDE74_RS07410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DDE74_RS07415	COG0217	transcriptional regulatory protein
DDE74_RS07420	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DDE74_RS07425	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DDE74_RS07435	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS07440	COG1560	Kdo2-lipid A biosynthetic process
DDE74_RS07445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DDE74_RS07480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DDE74_RS07495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DDE74_RS07550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DDE74_RS07645	COG1648	precorrin-2 dehydrogenase activity
DDE74_RS07645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DDE74_RS07650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DDE74_RS07665	COG1464	Belongs to the NlpA lipoprotein family
DDE74_RS07670	COG2011	ABC-type metal ion transport system permease component
DDE74_RS07675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DDE74_RS07705	COG0584	glycerophosphoryl diester phosphodiesterase
DDE74_RS07710	COG0204	Acyl-transferase
DDE74_RS07710	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS07720	COG0477	Major facilitator Superfamily
DDE74_RS07730	COG0165	Argininosuccinate lyase
DDE74_RS07735	COG0137	argininosuccinate synthase activity
DDE74_RS07770	COG1720	tRNA m6t6A37 methyltransferase activity
DDE74_RS07795	COG0668	transmembrane transport
DDE74_RS07800	COG1438	arginine binding
DDE74_RS07805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDE74_RS07810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DDE74_RS07815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DDE74_RS07820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DDE74_RS07830	COG4106	trans-aconitate 2-methyltransferase activity
DDE74_RS07845	COG0657	acetylesterase activity
DDE74_RS07880	COG0697	spore germination
DDE74_RS07890	COG1649	PFAM Uncharacterised BCR, COG1649
DDE74_RS07910	COG1136	(ABC) transporter
DDE74_RS07940	COG1051	belongs to the nudix hydrolase family
DDE74_RS07960	COG0072	phenylalanine-tRNA ligase activity
DDE74_RS07960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDE74_RS07965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DDE74_RS07970	COG5002	protein histidine kinase activity
DDE74_RS07975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDE74_RS07980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DDE74_RS07985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DDE74_RS07990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DDE74_RS08000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DDE74_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS08040	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS08050	COG2186	Transcriptional regulator
DDE74_RS08055	COG0531	amino acid
DDE74_RS08060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DDE74_RS08090	COG4175	Glycine betaine
DDE74_RS08090	COG0517	IMP dehydrogenase activity
DDE74_RS08095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DDE74_RS08125	COG3254	rhamnose metabolic process
DDE74_RS08140	COG0805	protein transport
DDE74_RS08145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DDE74_RS08165	COG2378	regulation of single-species biofilm formation
DDE74_RS08175	COG0544	peptidyl-prolyl cis-trans isomerase activity
DDE74_RS08180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DDE74_RS08190	COG1609	Transcriptional regulator
DDE74_RS08195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DDE74_RS08200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DDE74_RS08215	COG4122	O-methyltransferase activity
DDE74_RS08220	COG1222	aaa ATPase
DDE74_RS08245	COG1994	Peptidase M50
DDE74_RS08245	COG0517	IMP dehydrogenase activity
DDE74_RS08255	COG2197	response regulator
DDE74_RS08265	COG4166	transmembrane transport
DDE74_RS08270	COG0546	phosphoglycolate phosphatase activity
DDE74_RS08275	COG0646	methionine synthase
DDE74_RS08275	COG1410	methionine synthase
DDE74_RS08280	COG1414	Transcriptional regulator
DDE74_RS08285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DDE74_RS08290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDE74_RS08295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DDE74_RS08305	COG2186	Transcriptional regulator
DDE74_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS08330	COG1129	ABC transporter
DDE74_RS08340	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS08345	COG4948	Mandelate Racemase Muconate Lactonizing
DDE74_RS08355	COG0215	cysteine-tRNA ligase activity
DDE74_RS08375	COG0598	Magnesium transport protein CorA
DDE74_RS08385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDE74_RS08390	COG0667	Aldo Keto reductase
DDE74_RS08420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDE74_RS08430	COG0564	pseudouridine synthase activity
DDE74_RS08440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DDE74_RS08440	COG0515	serine threonine protein kinase
DDE74_RS08470	COG0488	(ABC) transporter
DDE74_RS08475	COG2124	cytochrome p450
DDE74_RS08485	COG0745	RESPONSE REGULATOR receiver
DDE74_RS08490	COG2205	protein histidine kinase activity
DDE74_RS08530	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DDE74_RS08555	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS08560	COG3963	phosphatidate phosphatase activity
DDE74_RS08565	COG1309	transcriptional regulator
DDE74_RS08570	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS08580	COG3876	Protein conserved in bacteria
DDE74_RS08585	COG0477	Major facilitator Superfamily
DDE74_RS08630	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS08640	COG0477	Major facilitator Superfamily
DDE74_RS08645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DDE74_RS08650	COG0546	phosphoglycolate phosphatase activity
DDE74_RS08715	COG2851	Citrate transporter
DDE74_RS08725	COG1309	transcriptional regulator
DDE74_RS08730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DDE74_RS08735	COG2188	Transcriptional regulator
DDE74_RS08740	COG2814	Major facilitator Superfamily
DDE74_RS08740	COG0477	Major facilitator Superfamily
DDE74_RS08780	COG1834	amidinotransferase
DDE74_RS08785	COG1725	Transcriptional regulator
DDE74_RS08805	COG1522	sequence-specific DNA binding
DDE74_RS08810	COG0531	amino acid
DDE74_RS08825	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DDE74_RS08835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DDE74_RS08840	COG0587	DNA-directed DNA polymerase activity
DDE74_RS08905	COG0330	HflC and HflK could
DDE74_RS08915	COG1126	abc transporter atp-binding protein
DDE74_RS08930	COG1799	cell septum assembly
DDE74_RS08935	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS08940	COG0477	Major facilitator Superfamily
DDE74_RS08950	COG0671	phosphoesterase, PA-phosphatase related
DDE74_RS08960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DDE74_RS08975	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS08985	COG3583	domain protein
DDE74_RS09000	COG1160	GTP binding
DDE74_RS09010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DDE74_RS09030	COG1187	pseudouridine synthase activity
DDE74_RS09035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DDE74_RS09040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DDE74_RS09055	COG0686	Belongs to the AlaDH PNT family
DDE74_RS09065	COG0494	nUDIX hydrolase
DDE74_RS09070	COG0504	CTP synthase activity
DDE74_RS09075	COG3387	PFAM Glycoside hydrolase 15-related
DDE74_RS09120	COG0497	DNA recombination
DDE74_RS09125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DDE74_RS09145	COG1120	ATPase activity
DDE74_RS09155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS09160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS09175	COG0647	UMP catabolic process
DDE74_RS09190	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DDE74_RS09230	COG2094	Belongs to the DNA glycosylase MPG family
DDE74_RS09240	COG1881	PFAM PEBP family protein
DDE74_RS09265	COG1119	ATPase activity
DDE74_RS09285	COG2197	response regulator
DDE74_RS09290	COG4585	Histidine kinase
DDE74_RS09310	COG1131	(ABC) transporter
DDE74_RS09310	COG1716	ATPase activity
DDE74_RS09310	COG0842	Transport permease protein
DDE74_RS09315	COG3830	Belongs to the UPF0237 family
DDE74_RS09315	COG0560	Phosphoserine phosphatase
DDE74_RS09335	COG2186	Transcriptional regulator
DDE74_RS09340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DDE74_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS09375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DDE74_RS09395	COG3415	Transposase
DDE74_RS09395	COG2801	Transposase and inactivated derivatives
DDE74_RS09400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DDE74_RS09405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDE74_RS09420	COG1404	Belongs to the peptidase S8 family
DDE74_RS09480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DDE74_RS09495	COG3387	PFAM Glycoside hydrolase 15-related
DDE74_RS09530	COG1302	Protein conserved in bacteria
DDE74_RS09550	COG0488	(ABC) transporter
DDE74_RS09565	COG0235	Class ii aldolase
DDE74_RS09580	COG1653	transport
DDE74_RS09600	COG1492	cobalamin metabolic process
DDE74_RS09615	COG1797	cobyrinic acid a,c-diamide synthase activity
DDE74_RS09625	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DDE74_RS09650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DDE74_RS09655	COG1917	Cupin 2, conserved barrel domain protein
DDE74_RS09685	COG2226	methyltransferase
DDE74_RS09700	COG1414	Transcriptional regulator
DDE74_RS09710	COG4585	Histidine kinase
DDE74_RS09730	COG2261	transglycosylase associated protein
DDE74_RS09760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDE74_RS09770	COG2171	N-acyltransferase activity
DDE74_RS09775	COG3226	Transcriptional regulator
DDE74_RS09780	COG2076	Multidrug Resistance protein
DDE74_RS09790	COG0822	iron-sulfur transferase activity
DDE74_RS09795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDE74_RS09800	COG0396	ATPase activity
DDE74_RS09810	COG0719	Fe-S assembly protein
DDE74_RS09825	COG1131	(ABC) transporter
DDE74_RS09850	COG0109	protoheme IX farnesyltransferase activity
DDE74_RS09860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DDE74_RS09875	COG0363	glucosamine-6-phosphate deaminase activity
DDE74_RS09880	COG0166	Belongs to the GPI family
DDE74_RS09895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DDE74_RS09900	COG0149	triose-phosphate isomerase activity
DDE74_RS09905	COG0126	phosphoglycerate kinase activity
DDE74_RS09910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DDE74_RS09915	COG1481	regulation of sporulation
DDE74_RS09920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DDE74_RS09925	COG1660	Displays ATPase and GTPase activities
DDE74_RS09930	COG0322	excinuclease ABC activity
DDE74_RS09960	COG1609	Transcriptional regulator
DDE74_RS09970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DDE74_RS10015	COG0556	nucleotide-excision repair
DDE74_RS10020	COG0584	glycerophosphoryl diester phosphodiesterase
DDE74_RS10075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DDE74_RS10115	COG0237	dephospho-CoA kinase activity
DDE74_RS10135	COG2226	methyltransferase
DDE74_RS10140	COG1643	Atp-dependent helicase
DDE74_RS10180	COG2050	protein possibly involved in aromatic compounds catabolism
DDE74_RS10235	COG0737	Belongs to the 5'-nucleotidase family
DDE74_RS10265	COG1470	cell adhesion involved in biofilm formation
DDE74_RS10265	COG0366	Alpha amylase catalytic
DDE74_RS10290	COG1609	Transcriptional regulator
DDE74_RS10300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDE74_RS10310	COG3467	pyridoxamine 5'-phosphate
DDE74_RS10325	COG0640	Transcriptional regulator
DDE74_RS10340	COG0069	glutamate synthase activity
DDE74_RS10340	COG0070	glutamate synthase
DDE74_RS10340	COG0067	glutamate synthase
DDE74_RS10370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDE74_RS10380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DDE74_RS10390	COG0159	tryptophan synthase activity
DDE74_RS10395	COG0133	tryptophan synthase activity
DDE74_RS10405	COG0134	indole-3-glycerol-phosphate synthase activity
DDE74_RS10430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DDE74_RS10440	COG0583	DNA-binding transcription factor activity
DDE74_RS10450	COG1053	succinate dehydrogenase
DDE74_RS10455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DDE74_RS10465	COG0107	imidazoleglycerol-phosphate synthase activity
DDE74_RS10470	COG0251	oxidation-reduction process
DDE74_RS10475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DDE74_RS10480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DDE74_RS10485	COG0131	Imidazoleglycerol-phosphate dehydratase
DDE74_RS10490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDE74_RS10495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DDE74_RS10510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DDE74_RS10530	COG1432	Conserved Protein
DDE74_RS10535	COG0587	DNA-directed DNA polymerase activity
DDE74_RS10590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DDE74_RS10600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DDE74_RS10605	COG3599	regulation of cell shape
DDE74_RS10615	COG1799	cell septum assembly
DDE74_RS10620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DDE74_RS10635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DDE74_RS10640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DDE74_RS10650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DDE74_RS10655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DDE74_RS10660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DDE74_RS10665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DDE74_RS10680	COG0275	rRNA processing
DDE74_RS10690	COG0714	Associated with various cellular activities
DDE74_RS10710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DDE74_RS10730	COG1309	transcriptional regulator
DDE74_RS10740	COG1233	COG1233 Phytoene dehydrogenase and related
DDE74_RS10755	COG0352	thiamine-phosphate diphosphorylase activity
DDE74_RS10770	COG2022	thiamine diphosphate biosynthetic process
DDE74_RS10770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDE74_RS10780	COG2022	thiamine diphosphate biosynthetic process
DDE74_RS10785	COG0515	serine threonine protein kinase
DDE74_RS10785	COG2815	serine threonine protein kinase
DDE74_RS10790	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DDE74_RS10800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DDE74_RS10805	COG2193	ferroxidase activity
DDE74_RS10815	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DDE74_RS10825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DDE74_RS10830	COG0205	6-phosphofructokinase activity
DDE74_RS10835	COG2197	response regulator
DDE74_RS10865	COG1940	carbohydrate kinase activity
DDE74_RS10875	COG0003	Pfam Anion-transporting ATPase
DDE74_RS10895	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS10940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDE74_RS10945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DDE74_RS10950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DDE74_RS10955	COG0723	plastoquinol--plastocyanin reductase activity
DDE74_RS10960	COG2010	Cytochrome c
DDE74_RS10965	COG1845	cytochrome c oxidase, subunit III
DDE74_RS10975	COG1376	ErfK ybiS ycfS ynhG family protein
DDE74_RS10985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DDE74_RS10990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DDE74_RS11000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDE74_RS11020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DDE74_RS11035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDE74_RS11040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDE74_RS11045	COG2197	response regulator
DDE74_RS11050	COG4585	Histidine kinase
DDE74_RS11085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DDE74_RS11090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DDE74_RS11090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DDE74_RS11105	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DDE74_RS11110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DDE74_RS11115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDE74_RS11120	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE74_RS11130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DDE74_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS11170	COG0321	lipoyl(octanoyl) transferase activity
DDE74_RS11175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DDE74_RS11200	COG4974	Belongs to the 'phage' integrase family
DDE74_RS11295	COG2186	Transcriptional regulator
DDE74_RS11355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDE74_RS11370	COG0446	pyridine nucleotide-disulphide oxidoreductase
DDE74_RS11370	COG1902	pentaerythritol trinitrate reductase activity
DDE74_RS11375	COG1695	Transcriptional regulator
DDE74_RS11415	COG0745	RESPONSE REGULATOR receiver
DDE74_RS11440	COG2197	response regulator
DDE74_RS11480	COG1309	transcriptional regulator
DDE74_RS11540	COG0366	Alpha amylase catalytic
DDE74_RS11545	COG0395	ABC-type sugar transport system, permease component
DDE74_RS11555	COG1175	transmembrane transport
DDE74_RS11560	COG2182	Extracellular solute-binding protein
DDE74_RS11565	COG0366	Alpha amylase catalytic
DDE74_RS11570	COG1609	Transcriptional regulator
DDE74_RS11580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DDE74_RS11585	COG0174	glutamine synthetase
DDE74_RS11590	COG2267	carboxylic ester hydrolase activity
DDE74_RS11600	COG2132	Multicopper oxidase
DDE74_RS11605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DDE74_RS11605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDE74_RS11610	COG2814	Major facilitator Superfamily
DDE74_RS11620	COG1309	transcriptional regulator
DDE74_RS11625	COG0477	Major facilitator Superfamily
DDE74_RS11630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DDE74_RS11650	COG1994	Peptidase M50
DDE74_RS11665	COG0395	ABC-type sugar transport system, permease component
DDE74_RS11670	COG1175	transmembrane transport
DDE74_RS11685	COG2186	Transcriptional regulator
DDE74_RS11690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDE74_RS11710	COG5398	heme oxygenase
DDE74_RS11725	COG2837	iron assimilation
DDE74_RS11730	COG0672	)-iron permease
DDE74_RS11750	COG1834	amidinotransferase
DDE74_RS11760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DDE74_RS11765	COG2814	Major facilitator Superfamily
DDE74_RS11770	COG3540	Alkaline phosphatase
DDE74_RS11780	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS11805	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DDE74_RS11810	COG3022	response to hydroperoxide
DDE74_RS11815	COG0800	Aldolase
DDE74_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS11850	COG2030	dehydratase
DDE74_RS11855	COG1131	(ABC) transporter
DDE74_RS11865	COG4585	Histidine kinase
DDE74_RS11870	COG2197	response regulator
DDE74_RS11880	COG0183	Belongs to the thiolase family
DDE74_RS11885	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS11895	COG0860	N-Acetylmuramoyl-L-alanine amidase
DDE74_RS11905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDE74_RS11925	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS11930	COG1309	transcriptional regulator
DDE74_RS11965	COG3845	ABC transporter
DDE74_RS11980	COG0183	Belongs to the thiolase family
DDE74_RS11985	COG2124	cytochrome p450
DDE74_RS12010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DDE74_RS12135	COG1072	(Pantothenic acid kinase))
DDE74_RS12150	COG0596	Alpha beta hydrolase
DDE74_RS12165	COG2259	Doxx family
DDE74_RS12170	COG1024	Enoyl-CoA hydratase
DDE74_RS12175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDE74_RS12195	COG0583	DNA-binding transcription factor activity
DDE74_RS12250	COG4948	Mandelate Racemase Muconate Lactonizing
DDE74_RS12255	COG0800	Aldolase
DDE74_RS12270	COG2801	Transposase and inactivated derivatives
DDE74_RS12270	COG3415	Transposase
DDE74_RS12285	COG4585	Histidine kinase
DDE74_RS12290	COG0586	Pfam SNARE associated Golgi protein
DDE74_RS12300	COG1358	cellular component organization or biogenesis
DDE74_RS12345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DDE74_RS12355	COG0477	Major facilitator Superfamily
DDE74_RS12360	COG1309	transcriptional regulator
DDE74_RS12375	COG4585	Histidine kinase
DDE74_RS12380	COG2197	response regulator
DDE74_RS12390	COG0667	Aldo Keto reductase
DDE74_RS12395	COG0789	Transcriptional regulator
DDE74_RS12420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDE74_RS12425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDE74_RS12430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDE74_RS12485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDE74_RS12495	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDE74_RS12500	COG1129	ABC transporter
DDE74_RS12505	COG1609	Transcriptional regulator
DDE74_RS12510	COG1764	response to oxidative stress
DDE74_RS12515	COG2130	NADP-dependent
DDE74_RS12525	COG0477	Major facilitator Superfamily
DDE74_RS12550	COG0500	methyltransferase
DDE74_RS12555	COG4981	capsule polysaccharide biosynthetic process
DDE74_RS12575	COG2835	tetraacyldisaccharide 4'-kinase activity
DDE74_RS12590	COG1077	Cell shape determining protein MreB Mrl
DDE74_RS12595	COG0588	phosphoglycerate mutase activity
DDE74_RS12600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DDE74_RS12700	COG1070	Carbohydrate kinase
DDE74_RS12705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DDE74_RS12710	COG0358	DNA primase activity
DDE74_RS12725	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DDE74_RS12735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDE74_RS12775	COG0656	L-ascorbic acid biosynthetic process
DDE74_RS12795	COG3795	YCII-related domain
DDE74_RS12800	COG4941	Belongs to the sigma-70 factor family
DDE74_RS12825	COG2146	nitrite reductase [NAD(P)H] activity
DDE74_RS12825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDE74_RS12840	COG0640	Transcriptional regulator
DDE74_RS12850	COG0531	amino acid
DDE74_RS12895	COG2182	Extracellular solute-binding protein
DDE74_RS12900	COG1175	transmembrane transport
DDE74_RS12905	COG0395	ABC-type sugar transport system, permease component
DDE74_RS12910	COG2175	clavaminate synthase activity
DDE74_RS12925	COG0574	Belongs to the PEP-utilizing enzyme family
DDE74_RS12925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDE74_RS12930	COG0477	Major facilitator Superfamily
DDE74_RS12960	COG0477	Major facilitator Superfamily
DDE74_RS12965	COG0667	Aldo Keto reductase
DDE74_RS12970	COG1309	transcriptional regulator
DDE74_RS12990	COG2197	response regulator
DDE74_RS13005	COG0423	glycine-tRNA ligase activity
DDE74_RS13010	COG3443	Belongs to the bacterial solute-binding protein 9 family
DDE74_RS13010	COG0803	Belongs to the bacterial solute-binding protein 9 family
DDE74_RS13015	COG1121	(ABC) transporter
DDE74_RS13020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDE74_RS13030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DDE74_RS13035	COG1381	Involved in DNA repair and RecF pathway recombination
DDE74_RS13075	COG2124	cytochrome p450
DDE74_RS13090	COG2755	lipolytic protein G-D-S-L family
DDE74_RS13095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDE74_RS13115	COG2723	6-phospho-beta-galactosidase activity
DDE74_RS13125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DDE74_RS13150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DDE74_RS13165	COG1486	melibiose metabolic process
DDE74_RS13190	COG4948	Mandelate Racemase Muconate Lactonizing
DDE74_RS13200	COG1234	tRNA 3'-trailer cleavage
DDE74_RS13205	COG0537	adenosine 5'-monophosphoramidase activity
DDE74_RS13230	COG0484	heat shock protein binding
DDE74_RS13235	COG1420	regulation of RNA biosynthetic process
DDE74_RS13270	COG0481	GTPase activity
DDE74_RS13275	COG0268	Binds directly to 16S ribosomal RNA
DDE74_RS13295	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DDE74_RS13300	COG1959	2 iron, 2 sulfur cluster binding
DDE74_RS13320	COG1307	EDD domain protein, DegV family
DDE74_RS13330	COG0495	leucyl-tRNA aminoacylation
DDE74_RS13365	COG0588	phosphoglycerate mutase activity
DDE74_RS13370	COG0799	negative regulation of ribosome biogenesis
DDE74_RS13380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DDE74_RS13385	COG0501	Belongs to the peptidase M48B family
DDE74_RS13400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DDE74_RS13410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DDE74_RS13420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DDE74_RS13425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DDE74_RS13430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DDE74_RS13435	COG1530	ribonuclease E activity
DDE74_RS13470	COG0772	Belongs to the SEDS family
DDE74_RS13475	COG0768	penicillin binding
DDE74_RS13490	COG1077	Cell shape determining protein MreB Mrl
DDE74_RS13495	COG0105	UTP biosynthetic process
DDE74_RS13505	COG0285	dihydrofolate synthase activity
DDE74_RS13510	COG0768	penicillin binding
DDE74_RS13515	COG0525	valine-tRNA ligase activity
DDE74_RS13525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DDE74_RS13530	COG0740	serine-type endopeptidase activity
DDE74_RS13535	COG0740	serine-type endopeptidase activity
DDE74_RS13540	COG0544	peptidyl-prolyl cis-trans isomerase activity
DDE74_RS13565	COG3594	Acyltransferase
DDE74_RS13575	COG4552	Acetyltransferase involved in intracellular survival and related
DDE74_RS13585	COG0698	ribose 5-phosphate isomerase
DDE74_RS13590	COG1113	amino acid transport
DDE74_RS13600	COG1113	amino acid transport
DDE74_RS13605	COG1113	amino acid transport
DDE74_RS13610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DDE74_RS13615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DDE74_RS13660	COG4266	Belongs to the allantoicase family
DDE74_RS13700	COG0668	transmembrane transport
DDE74_RS13705	COG1846	Transcriptional regulator
DDE74_RS13705	COG1940	carbohydrate kinase activity
DDE74_RS13710	COG1486	melibiose metabolic process
DDE74_RS13725	COG2186	Transcriptional regulator
DDE74_RS13735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDE74_RS13770	COG2346	COG2346, Truncated hemoglobins
DDE74_RS13810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DDE74_RS13880	COG1063	alcohol dehydrogenase
DDE74_RS13885	COG0395	ABC-type sugar transport system, permease component
DDE74_RS13890	COG1175	transmembrane transport
DDE74_RS13900	COG3842	ATPase activity
DDE74_RS13915	COG0395	ABC-type sugar transport system, permease component
DDE74_RS13920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDE74_RS13930	COG1349	DNA-binding transcription factor activity
DDE74_RS13940	COG1113	amino acid transport
DDE74_RS13960	COG3321	synthase
DDE74_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS13960	COG0604	alcohol dehydrogenase
DDE74_RS13965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDE74_RS13995	COG0596	Alpha beta hydrolase
DDE74_RS14015	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DDE74_RS14025	COG1131	(ABC) transporter
DDE74_RS14030	COG2205	protein histidine kinase activity
DDE74_RS14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDE74_RS14050	COG3962	Belongs to the TPP enzyme family
DDE74_RS14055	COG3718	enzyme involved in inositol metabolism
DDE74_RS14065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDE74_RS14075	COG0673	inositol 2-dehydrogenase activity
DDE74_RS14080	COG2814	Major facilitator Superfamily
DDE74_RS14085	COG3409	Peptidoglycan-binding domain 1 protein
DDE74_RS14100	COG0673	inositol 2-dehydrogenase activity
DDE74_RS14105	COG0586	Pfam SNARE associated Golgi protein
DDE74_RS14120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DDE74_RS14135	COG0673	inositol 2-dehydrogenase activity
DDE74_RS14150	COG1472	Belongs to the glycosyl hydrolase 3 family
DDE74_RS14170	COG1131	(ABC) transporter
DDE74_RS14170	COG1716	ATPase activity
DDE74_RS14170	COG0842	Transport permease protein
DDE74_RS14180	COG1309	transcriptional regulator
DDE74_RS14260	COG1946	Acyl-CoA thioesterase
DDE74_RS14270	COG1309	transcriptional regulator
DDE74_RS14275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDE74_RS14290	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS14305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDE74_RS14310	COG0589	response to stress
DDE74_RS14320	COG4977	sequence-specific DNA binding
DDE74_RS14325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DDE74_RS14335	COG2910	NAD(P)H-binding
DDE74_RS14345	COG3979	chitinase
DDE74_RS14365	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DDE74_RS14380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DDE74_RS14390	COG0492	ferredoxin-NADP+ reductase activity
DDE74_RS14450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDE74_RS14470	COG0154	amidase activity
DDE74_RS14485	COG0765	amino acid transport
DDE74_RS14490	COG0765	amino acid transport
DDE74_RS14495	COG1126	abc transporter atp-binding protein
DDE74_RS14510	COG3397	chitin binding
DDE74_RS14600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDE74_RS14605	COG2188	Transcriptional regulator
DDE74_RS14615	COG0673	inositol 2-dehydrogenase activity
DDE74_RS14645	COG0706	membrane insertase activity
DDE74_RS14690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDE74_RS14700	COG3764	Sortase (surface protein transpeptidase)
DDE74_RS14705	COG2733	membrane
DDE74_RS14735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDE74_RS14745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DDE74_RS14760	COG2205	protein histidine kinase activity
DDE74_RS14790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DDE74_RS14805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DDE74_RS14810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDE74_RS14815	COG1263	PTS System
DDE74_RS14820	COG1263	PTS System
DDE74_RS14825	COG0463	Glycosyl transferase, family 2
DDE74_RS14835	COG1234	tRNA 3'-trailer cleavage
DDE74_RS14860	COG1113	amino acid transport
DDE74_RS14870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DDE74_RS14880	COG1335	isochorismatase
DDE74_RS14915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDE74_RS14920	COG0222	ribosome binding
DDE74_RS14930	COG2080	2 iron, 2 sulfur cluster binding
DDE74_RS14930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDE74_RS14940	COG0277	FAD linked oxidase domain protein
DDE74_RS14945	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DDE74_RS14955	COG1174	glycine betaine transport
DDE74_RS14960	COG1125	glycine betaine transport
DDE74_RS14960	COG0517	IMP dehydrogenase activity
DDE74_RS14965	COG1174	glycine betaine transport
DDE74_RS14990	COG0477	Major facilitator Superfamily
DDE74_RS14995	COG0596	Alpha beta hydrolase
DDE74_RS15005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS15020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDE74_RS15050	COG1678	Uncharacterized ACR, COG1678
DDE74_RS15055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DDE74_RS15065	COG0776	regulation of translation
DDE74_RS15080	COG3973	AAA domain
DDE74_RS15080	COG3973	AAA domain
DDE74_RS15110	COG2223	nitrite transmembrane transporter activity
DDE74_RS15130	COG0583	DNA-binding transcription factor activity
DDE74_RS15150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DDE74_RS15155	COG0793	Belongs to the peptidase S41A family
DDE74_RS15160	COG2177	Part of the ABC transporter FtsEX involved in
DDE74_RS15165	COG2884	Cell division ATP-binding protein ftsE
DDE74_RS15180	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DDE74_RS15185	COG0515	serine threonine protein kinase
DDE74_RS15190	COG0515	serine threonine protein kinase
DDE74_RS15200	COG1653	transport
DDE74_RS15205	COG1175	transmembrane transport
DDE74_RS15210	COG0395	ABC-type sugar transport system, permease component
DDE74_RS15225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DDE74_RS15230	COG1215	transferase activity, transferring glycosyl groups
DDE74_RS15230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DDE74_RS15240	COG2226	methyltransferase
DDE74_RS15255	COG1215	transferase activity, transferring glycosyl groups
DDE74_RS15265	COG0463	Glycosyl transferase, family 2
DDE74_RS15265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DDE74_RS15270	COG1309	transcriptional regulator
DDE74_RS15280	COG1134	teichoic acid transport
DDE74_RS15285	COG2902	Dehydrogenase
DDE74_RS15290	COG0546	phosphoglycolate phosphatase activity
DDE74_RS15305	COG0653	protein targeting
DDE74_RS15315	COG3214	Protein conserved in bacteria
DDE74_RS15320	COG2197	response regulator
DDE74_RS15325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DDE74_RS15340	COG0823	Involved in the tonB-independent uptake of proteins
DDE74_RS15345	COG5002	protein histidine kinase activity
DDE74_RS15350	COG0745	RESPONSE REGULATOR receiver
DDE74_RS15355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DDE74_RS15375	COG0714	Associated with various cellular activities
DDE74_RS15420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DDE74_RS15425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DDE74_RS15425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DDE74_RS15425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDE74_RS15440	COG1482	cell wall glycoprotein biosynthetic process
DDE74_RS15450	COG2835	tetraacyldisaccharide 4'-kinase activity
DDE74_RS15490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DDE74_RS15495	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DDE74_RS15495	COG0778	Nitroreductase
DDE74_RS15525	COG1316	TRANSCRIPTIONal
DDE74_RS15540	COG1316	TRANSCRIPTIONal
DDE74_RS15560	COG1316	TRANSCRIPTIONal
DDE74_RS15570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DDE74_RS15610	COG5002	protein histidine kinase activity
DDE74_RS15615	COG0745	RESPONSE REGULATOR receiver
DDE74_RS15620	COG3104	oligopeptide transport
DDE74_RS15660	COG1366	Belongs to the anti-sigma-factor antagonist family
DDE74_RS15665	COG1191	sigma factor activity
DDE74_RS15670	COG1228	amidohydrolase
DDE74_RS15680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDE74_RS15685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DDE74_RS15735	COG1174	glycine betaine transport
DDE74_RS15740	COG1174	glycine betaine transport
DDE74_RS15755	COG1609	Transcriptional regulator
DDE74_RS15770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DDE74_RS15785	COG2755	lipolytic protein G-D-S-L family
DDE74_RS15790	COG0183	Belongs to the thiolase family
DDE74_RS15815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DDE74_RS15815	COG0463	Glycosyl transferase, family 2
DDE74_RS15830	COG0577	efflux transmembrane transporter activity
DDE74_RS15830	COG1136	(ABC) transporter
DDE74_RS15835	COG0577	efflux transmembrane transporter activity
DDE74_RS15835	COG1136	(ABC) transporter
DDE74_RS15840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DDE74_RS15865	COG0148	phosphopyruvate hydratase activity
DDE74_RS15880	COG2124	cytochrome p450
DDE74_RS15885	COG0583	DNA-binding transcription factor activity
DDE74_RS15890	COG2814	Major facilitator Superfamily
DDE74_RS15915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DDE74_RS15940	COG2815	serine threonine protein kinase
DDE74_RS15940	COG0515	serine threonine protein kinase
DDE74_RS15970	COG2814	Major facilitator Superfamily
DDE74_RS15980	COG1316	TRANSCRIPTIONal
DDE74_RS16005	COG4585	Histidine kinase
DDE74_RS16020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DDE74_RS16025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DDE74_RS16030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DDE74_RS16035	COG0193	aminoacyl-tRNA hydrolase activity
DDE74_RS16045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DDE74_RS16055	COG1309	transcriptional regulator
DDE74_RS16085	COG4106	trans-aconitate 2-methyltransferase activity
DDE74_RS16105	COG2197	response regulator
DDE74_RS16110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DDE74_RS16150	COG3209	COG3209 Rhs family protein
DDE74_RS16150	COG4104	PAAR repeat-containing protein
DDE74_RS16170	COG0488	(ABC) transporter
DDE74_RS16215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DDE74_RS16220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DDE74_RS16225	COG3584	3D domain protein
DDE74_RS16225	COG3583	domain protein
DDE74_RS16230	COG0084	hydrolase, TatD family'
DDE74_RS16260	COG1090	epimerase
DDE74_RS16275	COG1122	ATPase activity
DDE74_RS16285	COG0310	cobalt ion transport
DDE74_RS16290	COG4946	Tricorn protease homolog
DDE74_RS16290	COG0793	Belongs to the peptidase S41A family
DDE74_RS16315	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS16320	COG2267	carboxylic ester hydrolase activity
DDE74_RS16325	COG2072	flavoprotein involved in K transport
DDE74_RS16335	COG3903	Transcriptional regulator
DDE74_RS16335	COG3629	intracellular signal transduction
DDE74_RS16355	COG0708	Exodeoxyribonuclease III
DDE74_RS16375	COG1725	Transcriptional regulator
DDE74_RS16380	COG0789	Transcriptional regulator
DDE74_RS16410	COG0521	Mo-molybdopterin cofactor biosynthetic process
DDE74_RS16410	COG0315	cyclic pyranopterin monophosphate synthase activity
DDE74_RS16415	COG0315	cyclic pyranopterin monophosphate synthase activity
DDE74_RS16425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DDE74_RS16430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DDE74_RS16440	COG3263	regulation of cellular component size
DDE74_RS16455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DDE74_RS16460	COG1970	mechanosensitive ion channel activity
DDE74_RS16480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DDE74_RS16485	COG0477	Major facilitator Superfamily
DDE74_RS16495	COG2188	Transcriptional regulator
DDE74_RS16580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDE74_RS16585	COG1376	ErfK ybiS ycfS ynhG family protein
DDE74_RS16610	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DDE74_RS16610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DDE74_RS16610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DDE74_RS16615	COG1105	Belongs to the carbohydrate kinase PfkB family
DDE74_RS16620	COG1349	DNA-binding transcription factor activity
DDE74_RS16630	COG1247	-acetyltransferase
DDE74_RS16655	COG1846	Transcriptional regulator
DDE74_RS16675	COG1309	transcriptional regulator
DDE74_RS16700	COG0515	serine threonine protein kinase
DDE74_RS16715	COG1136	(ABC) transporter
DDE74_RS16720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DDE74_RS16740	COG0514	ATP-dependent DNA helicase (RecQ)
DDE74_RS16765	COG1686	Belongs to the peptidase S11 family
DDE74_RS16800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDE74_RS16810	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS16825	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDE74_RS16865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDE74_RS16880	COG2319	Wd-40 repeat
DDE74_RS16945	COG1024	Enoyl-CoA hydratase
DDE74_RS16960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDE74_RS16960	COG0515	serine threonine protein kinase
DDE74_RS16965	COG1309	transcriptional regulator
DDE74_RS16975	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS17005	COG0259	pyridoxamine-phosphate oxidase activity
DDE74_RS17030	COG1024	Enoyl-CoA hydratase
DDE74_RS17060	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS17080	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS17085	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS17165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DDE74_RS17185	COG1846	Transcriptional regulator
DDE74_RS17195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DDE74_RS17205	COG0516	GMP reductase activity
DDE74_RS17215	COG1595	DNA-templated transcription, initiation
DDE74_RS17220	COG2197	response regulator
DDE74_RS17230	COG0583	DNA-binding transcription factor activity
DDE74_RS17240	COG4221	oxidoreductase activity
DDE74_RS17250	COG0459	protein refolding
DDE74_RS17255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DDE74_RS17275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DDE74_RS17300	COG0802	atpase or kinase
DDE74_RS17310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DDE74_RS17325	COG0736	holo-[acyl-carrier-protein] synthase activity
DDE74_RS17330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDE74_RS17340	COG1072	(Pantothenic acid kinase))
DDE74_RS17350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DDE74_RS17355	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DDE74_RS17360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DDE74_RS17365	COG0488	(ABC) transporter
DDE74_RS17375	COG0101	tRNA pseudouridine synthase activity
DDE74_RS17380	COG0203	ribosomal protein L17
DDE74_RS17385	COG0202	RNA polymerase activity
DDE74_RS17390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DDE74_RS17395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DDE74_RS17400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DDE74_RS17405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DDE74_RS17410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DDE74_RS17420	COG0563	adenylate kinase activity
DDE74_RS17430	COG0200	Binds to the 23S rRNA
DDE74_RS17435	COG1841	ribosomal large subunit assembly
DDE74_RS17440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DDE74_RS17445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DDE74_RS17450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DDE74_RS17455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DDE74_RS17465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDE74_RS17470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DDE74_RS17475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DDE74_RS17480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DDE74_RS17485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DDE74_RS17490	COG0255	Belongs to the universal ribosomal protein uL29 family
DDE74_RS17495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DDE74_RS17500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DDE74_RS17505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DDE74_RS17510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DDE74_RS17515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DDE74_RS17520	COG0089	rRNA binding
DDE74_RS17525	COG0088	Forms part of the polypeptide exit tunnel
DDE74_RS17530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DDE74_RS17535	COG0051	transcription antitermination factor activity, RNA binding
DDE74_RS17540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DDE74_RS17545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DDE74_RS17550	COG0049	tRNA binding
DDE74_RS17555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DDE74_RS17595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DDE74_RS17600	COG0085	RNA polymerase activity
DDE74_RS17610	COG0222	ribosome binding
DDE74_RS17615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DDE74_RS17620	COG0081	regulation of translation
DDE74_RS17625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DDE74_RS17630	COG0250	Participates in transcription elongation, termination and antitermination
DDE74_RS17645	COG0436	Aminotransferase
DDE74_RS17650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDE74_RS17655	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DDE74_RS17670	COG2030	dehydratase
DDE74_RS17675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DDE74_RS17700	COG1846	Transcriptional regulator
DDE74_RS17715	COG1666	GTP binding
DDE74_RS17725	COG3304	Inner membrane component domain
DDE74_RS17730	COG0501	Belongs to the peptidase M48B family
DDE74_RS17735	COG1007	ATP synthesis coupled electron transport
DDE74_RS17745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DDE74_RS17750	COG0713	ATP synthesis coupled electron transport
DDE74_RS17755	COG0839	Belongs to the complex I subunit 6 family
DDE74_RS17760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDE74_RS17765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DDE74_RS17770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDE74_RS17775	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDE74_RS17780	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDE74_RS17795	COG4585	Histidine kinase
DDE74_RS17805	COG4585	Histidine kinase
DDE74_RS17815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DDE74_RS17815	COG0674	pyruvate-flavodoxin oxidoreductase activity
DDE74_RS17820	COG1013	pyruvate-flavodoxin oxidoreductase activity
DDE74_RS17825	COG0702	epimerase
DDE74_RS17840	COG1131	(ABC) transporter
DDE74_RS17850	COG0142	geranyltranstransferase activity
DDE74_RS17875	COG1007	ATP synthesis coupled electron transport
DDE74_RS17885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DDE74_RS17890	COG0713	ATP synthesis coupled electron transport
DDE74_RS17895	COG0839	Belongs to the complex I subunit 6 family
DDE74_RS17900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDE74_RS17905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DDE74_RS17910	COG1034	ATP synthesis coupled electron transport
DDE74_RS17915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DDE74_RS17925	COG0649	NAD binding
DDE74_RS17930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDE74_RS17935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDE74_RS17945	COG0791	NLP P60 protein
DDE74_RS17945	COG1388	LysM domain
DDE74_RS17945	COG3103	Sh3 type 3 domain protein
DDE74_RS17965	COG2226	methyltransferase
DDE74_RS17975	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDE74_RS17985	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DDE74_RS17990	COG1278	Cold shock
DDE74_RS17995	COG1674	ftsk spoiiie
DDE74_RS18010	COG1404	Belongs to the peptidase S8 family
DDE74_RS18025	COG1404	Belongs to the peptidase S8 family
DDE74_RS18120	COG1309	transcriptional regulator
DDE74_RS18145	COG1301	dicarboxylic acid transport
DDE74_RS18160	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDE74_RS18170	COG0163	prenyltransferase activity
DDE74_RS18185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DDE74_RS18190	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DDE74_RS18215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DDE74_RS18220	COG1333	cytochrome c biogenesis protein
DDE74_RS18225	COG0785	Cytochrome C biogenesis protein
DDE74_RS18240	COG0406	alpha-ribazole phosphatase activity
DDE74_RS18245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DDE74_RS18280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS18290	COG1742	UPF0060 membrane protein
DDE74_RS18310	COG1690	Belongs to the RtcB family
DDE74_RS18335	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DDE74_RS18340	COG0018	arginyl-trna synthetase
DDE74_RS18350	COG0113	porphobilinogen synthase activity
DDE74_RS18355	COG1648	precorrin-2 dehydrogenase activity
DDE74_RS18355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DDE74_RS18360	COG0181	hydroxymethylbilane synthase activity
DDE74_RS18365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DDE74_RS18370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DDE74_RS18420	COG0123	including yeast histone deacetylase and acetoin utilization protein
DDE74_RS18430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDE74_RS18465	COG1252	NADH dehydrogenase
DDE74_RS18490	COG0579	oxidoreductase
DDE74_RS18500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DDE74_RS18590	COG0513	Belongs to the DEAD box helicase family
DDE74_RS18630	COG1643	Atp-dependent helicase
DDE74_RS18665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DDE74_RS18690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DDE74_RS18695	COG0047	phosphoribosylformylglycinamidine synthase activity
DDE74_RS18700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DDE74_RS18735	COG2197	response regulator
DDE74_RS18745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DDE74_RS18750	COG2814	Major facilitator Superfamily
DDE74_RS18755	COG0583	DNA-binding transcription factor activity
DDE74_RS18770	COG0151	Belongs to the GarS family
DDE74_RS18785	COG1802	Transcriptional regulator
DDE74_RS18790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DDE74_RS18820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DDE74_RS18835	COG1131	(ABC) transporter
DDE74_RS18840	COG3559	Exporter of polyketide antibiotics
DDE74_RS18850	COG2197	response regulator
DDE74_RS18855	COG4585	Histidine kinase
DDE74_RS18865	COG3844	kynureninase activity
DDE74_RS18870	COG3483	tryptophan 2,3-dioxygenase activity
DDE74_RS18885	COG0191	fructose-bisphosphate aldolase activity
DDE74_RS18890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DDE74_RS18905	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DDE74_RS18950	COG0542	response to heat
DDE74_RS18975	COG0789	Transcriptional regulator
DDE74_RS18980	COG0484	heat shock protein binding
DDE74_RS18985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DDE74_RS18990	COG0443	Heat shock 70 kDa protein
DDE74_RS18995	COG2181	nitrate reductase activity
DDE74_RS18995	COG0247	lactate metabolic process
DDE74_RS19015	COG2755	lipolytic protein G-D-S-L family
DDE74_RS19025	COG0717	Belongs to the dCTP deaminase family
DDE74_RS19140	COG0577	efflux transmembrane transporter activity
DDE74_RS19145	COG1136	(ABC) transporter
DDE74_RS19145	COG0577	efflux transmembrane transporter activity
DDE74_RS19150	COG2197	response regulator
DDE74_RS19155	COG4585	Histidine kinase
DDE74_RS19195	COG0513	Belongs to the DEAD box helicase family
DDE74_RS19200	COG1278	Cold shock
DDE74_RS19230	COG2124	cytochrome p450
DDE74_RS19230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DDE74_RS19240	COG0596	Alpha beta hydrolase
DDE74_RS19250	COG1136	(ABC) transporter
DDE74_RS19250	COG0577	efflux transmembrane transporter activity
DDE74_RS19255	COG1136	(ABC) transporter
DDE74_RS19255	COG0577	efflux transmembrane transporter activity
DDE74_RS19260	COG2197	response regulator
DDE74_RS19265	COG4585	Histidine kinase
DDE74_RS19280	COG0436	Aminotransferase
DDE74_RS19285	COG3226	Transcriptional regulator
DDE74_RS19290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDE74_RS19320	COG1846	Transcriptional regulator
DDE74_RS19340	COG1674	ftsk spoiiie
DDE74_RS19365	COG0737	Belongs to the 5'-nucleotidase family
DDE74_RS19365	COG1525	nuclease
DDE74_RS19365	COG4085	toxin activity
DDE74_RS19415	COG0515	serine threonine protein kinase
DDE74_RS19425	COG2124	cytochrome p450
DDE74_RS19450	COG0515	serine threonine protein kinase
DDE74_RS19450	COG2815	serine threonine protein kinase
DDE74_RS19495	COG4585	Histidine kinase
DDE74_RS19500	COG2197	response regulator
DDE74_RS19520	COG1131	(ABC) transporter
DDE74_RS19535	COG2197	response regulator
DDE74_RS19575	COG1316	TRANSCRIPTIONal
DDE74_RS19625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDE74_RS19630	COG3739	integral membrane protein
DDE74_RS19655	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DDE74_RS19705	COG0745	RESPONSE REGULATOR receiver
DDE74_RS19710	COG0517	IMP dehydrogenase activity
DDE74_RS19710	COG1125	glycine betaine transport
DDE74_RS19715	COG1732	Glycine betaine
DDE74_RS19720	COG1174	glycine betaine transport
DDE74_RS19725	COG1174	glycine betaine transport
DDE74_RS19730	COG0726	polysaccharide deacetylase
DDE74_RS19755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDE74_RS19765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DDE74_RS19790	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS19795	COG1362	aminopeptidase activity
DDE74_RS19800	COG3903	Transcriptional regulator
DDE74_RS19800	COG3629	intracellular signal transduction
DDE74_RS19840	COG2223	nitrite transmembrane transporter activity
DDE74_RS19850	COG0494	nUDIX hydrolase
DDE74_RS19865	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE74_RS19870	COG0022	dehydrogenase e1 component
DDE74_RS19890	COG0515	serine threonine protein kinase
DDE74_RS19895	COG0515	serine threonine protein kinase
DDE74_RS19910	COG0604	alcohol dehydrogenase
DDE74_RS19915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDE74_RS19920	COG0303	'Molybdopterin
DDE74_RS19925	COG0746	molybdenum cofactor guanylyltransferase activity
DDE74_RS19945	COG1522	sequence-specific DNA binding
DDE74_RS19950	COG1309	transcriptional regulator
DDE74_RS19955	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDE74_RS19980	COG3396	Phenylacetate-CoA oxygenase
DDE74_RS19985	COG3460	Phenylacetate-CoA oxygenase
DDE74_RS19990	COG3396	Phenylacetate-CoA oxygenase
DDE74_RS19995	COG2151	metal-sulfur cluster biosynthetic enzyme
DDE74_RS20000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DDE74_RS20035	COG1733	regulation of RNA biosynthetic process
DDE74_RS20040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DDE74_RS20050	COG0583	DNA-binding transcription factor activity
DDE74_RS20060	COG1716	ATPase activity
DDE74_RS20065	COG1716	ATPase activity
DDE74_RS20080	COG0768	penicillin binding
DDE74_RS20090	COG0515	serine threonine protein kinase
DDE74_RS20095	COG3764	Sortase (surface protein transpeptidase)
DDE74_RS20100	COG3764	Sortase (surface protein transpeptidase)
DDE74_RS20110	COG3764	Sortase (surface protein transpeptidase)
DDE74_RS20125	COG0705	Rhomboid family
DDE74_RS20150	COG0515	serine threonine protein kinase
DDE74_RS20180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDE74_RS20190	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DDE74_RS20195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DDE74_RS20200	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DDE74_RS20205	COG0592	DNA-directed DNA polymerase activity
DDE74_RS20220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DDE74_RS20225	COG0594	ribonuclease P activity
DDE74_RS20230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DDE74_RS20235	COG0706	membrane insertase activity
DDE74_RS20240	COG1847	R3H domain protein
DDE74_RS20245	COG0357	Ribosomal RNA small subunit methyltransferase G
DDE74_RS20250	COG1192	Involved in chromosome partitioning
DDE74_RS20265	COG3118	belongs to the thioredoxin family
DDE74_RS20270	COG0492	ferredoxin-NADP+ reductase activity
DDE74_RS20280	COG1595	DNA-templated transcription, initiation
DDE74_RS20290	COG0515	serine threonine protein kinase
DDE74_RS20290	COG2815	serine threonine protein kinase
DDE74_RS20305	COG0617	tRNA 3'-terminal CCA addition
DDE74_RS20330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDE74_RS20355	COG0360	Binds together with S18 to 16S ribosomal RNA
DDE74_RS20360	COG0629	single-stranded DNA binding
DDE74_RS20365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DDE74_RS20370	COG0359	binds to the 23S rRNA
DDE74_RS20385	COG0305	Participates in initiation and elongation during chromosome replication
DDE74_RS20460	COG2814	Major facilitator Superfamily
DDE74_RS20500	COG0626	cystathionine gamma-synthase activity
DDE74_RS20505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DDE74_RS20510	COG1950	PFAM Membrane protein of
DDE74_RS20515	COG0662	Cupin 2, conserved barrel domain protein
DDE74_RS20540	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DDE74_RS20545	COG0346	lactoylglutathione lyase activity
DDE74_RS20560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DDE74_RS20565	COG1609	Transcriptional regulator
DDE74_RS20570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDE74_RS20575	COG1271	oxidase subunit
DDE74_RS20580	COG1294	oxidase, subunit
DDE74_RS20585	COG4988	ABC transporter
DDE74_RS20595	COG0561	phosphatase activity
DDE74_RS20605	COG0501	Belongs to the peptidase M48B family
DDE74_RS20615	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DDE74_RS20680	COG2807	transmembrane transport
DDE74_RS20685	COG2186	Transcriptional regulator
DDE74_RS20725	COG0561	phosphatase activity
DDE74_RS20730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DDE74_RS20735	COG0077	Prephenate dehydratase
DDE74_RS20740	COG2837	iron assimilation
DDE74_RS20745	COG2372	response to copper ion
DDE74_RS20755	COG1999	signal sequence binding
DDE74_RS20780	COG0006	proline dipeptidase activity
DDE74_RS20800	COG0653	protein targeting
DDE74_RS20815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDE74_RS20870	COG3409	Peptidoglycan-binding domain 1 protein
DDE74_RS20870	COG5632	N-Acetylmuramoyl-L-alanine amidase
DDE74_RS20895	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS20905	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS20930	COG1595	DNA-templated transcription, initiation
DDE74_RS20970	COG0662	Cupin 2, conserved barrel domain protein
DDE74_RS21010	COG3437	response regulator, receiver
DDE74_RS21015	COG4999	Histidine kinase
DDE74_RS21015	COG3850	Histidine kinase
DDE74_RS21015	COG3437	response regulator, receiver
DDE74_RS21015	COG2205	protein histidine kinase activity
DDE74_RS21040	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS21045	COG0784	Response regulator, receiver
DDE74_RS21095	COG2249	NAD(P)H dehydrogenase (quinone) activity
DDE74_RS21115	COG0431	NADPH-dependent FMN reductase
DDE74_RS21120	COG0745	RESPONSE REGULATOR receiver
DDE74_RS21125	COG2205	protein histidine kinase activity
DDE74_RS21135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DDE74_RS21135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DDE74_RS21140	COG0477	Major facilitator Superfamily
DDE74_RS21150	COG2353	YceI-like domain
DDE74_RS21155	COG0477	Major facilitator Superfamily
DDE74_RS21190	COG0402	S-adenosylhomocysteine deaminase activity
DDE74_RS21215	COG1191	sigma factor activity
DDE74_RS21220	COG1191	sigma factor activity
DDE74_RS21240	COG0590	tRNA wobble adenosine to inosine editing
DDE74_RS21255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DDE74_RS21275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DDE74_RS21305	COG2409	Drug exporters of the RND superfamily
DDE74_RS21320	COG1064	alcohol dehydrogenase
DDE74_RS21355	COG2268	Band 7 protein
DDE74_RS21375	COG0477	Major facilitator Superfamily
DDE74_RS21390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDE74_RS21440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDE74_RS21445	COG1834	amidinotransferase
DDE74_RS21480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS21490	COG1136	(ABC) transporter
DDE74_RS21500	COG2197	response regulator
DDE74_RS21515	COG2205	protein histidine kinase activity
DDE74_RS21520	COG0745	RESPONSE REGULATOR receiver
DDE74_RS21535	COG1136	(ABC) transporter
DDE74_RS21535	COG0577	efflux transmembrane transporter activity
DDE74_RS21540	COG0577	efflux transmembrane transporter activity
DDE74_RS21540	COG1136	(ABC) transporter
DDE74_RS21545	COG1132	(ABC) transporter
DDE74_RS21550	COG0531	amino acid
DDE74_RS21625	COG2197	response regulator
DDE74_RS21670	COG3335	DDE superfamily endonuclease
DDE74_RS21685	COG2815	serine threonine protein kinase
DDE74_RS21685	COG0515	serine threonine protein kinase
DDE74_RS21750	COG0105	UTP biosynthetic process
DDE74_RS21830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DDE74_RS21835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DDE74_RS21855	COG1595	DNA-templated transcription, initiation
DDE74_RS21900	COG1309	transcriptional regulator
DDE74_RS21910	COG1316	TRANSCRIPTIONal
DDE74_RS21945	COG2188	Transcriptional regulator
DDE74_RS21950	COG4249	Peptidase C14 caspase catalytic subunit p20
DDE74_RS21950	COG2319	Wd-40 repeat
DDE74_RS21965	COG1408	metallophosphoesterase
DDE74_RS21975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDE74_RS21985	COG0003	Pfam Anion-transporting ATPase
DDE74_RS22010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDE74_RS22045	COG2267	carboxylic ester hydrolase activity
DDE74_RS22055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DDE74_RS22060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DDE74_RS22120	COG1111	helicase
DDE74_RS22120	COG1205	dead DEAH box helicase
DDE74_RS22125	COG1366	Belongs to the anti-sigma-factor antagonist family
DDE74_RS22130	COG2172	sigma factor antagonist activity
DDE74_RS22135	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DDE74_RS22145	COG2890	protein-(glutamine-N5) methyltransferase activity
DDE74_RS22170	COG1754	DNA topoisomerase type I activity
DDE74_RS22170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DDE74_RS22175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DDE74_RS22180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DDE74_RS22200	COG1132	(ABC) transporter
DDE74_RS22220	COG5002	protein histidine kinase activity
DDE74_RS22225	COG0745	RESPONSE REGULATOR receiver
DDE74_RS22270	COG0531	amino acid
DDE74_RS22300	COG0644	oxidoreductase
DDE74_RS22315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS22320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDE74_RS22355	COG2175	clavaminate synthase activity
DDE74_RS22360	COG3251	PFAM MbtH domain protein
DDE74_RS22365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDE74_RS22385	COG0475	glutathione-regulated potassium exporter activity
DDE74_RS22400	COG2124	cytochrome p450
DDE74_RS22405	COG3903	Transcriptional regulator
DDE74_RS22405	COG3629	intracellular signal transduction
DDE74_RS22430	COG2205	protein histidine kinase activity
DDE74_RS22435	COG0745	RESPONSE REGULATOR receiver
DDE74_RS22460	COG2197	response regulator
DDE74_RS22465	COG0584	glycerophosphoryl diester phosphodiesterase
DDE74_RS22470	COG3594	Acyltransferase
DDE74_RS22485	COG1309	transcriptional regulator
DDE74_RS22545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DDE74_RS22545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDE74_RS22555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDE74_RS22560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DDE74_RS22565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DDE74_RS22570	COG0254	rRNA binding
DDE74_RS22580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DDE74_RS22600	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS22605	COG2318	DinB family
DDE74_RS22615	COG0076	glutamate decarboxylase activity
DDE74_RS22620	COG0655	NAD(P)H dehydrogenase (quinone) activity
DDE74_RS22630	COG0789	Transcriptional regulator
DDE74_RS22635	COG0393	Putative heavy-metal-binding
DDE74_RS22640	COG0586	Pfam SNARE associated Golgi protein
DDE74_RS22650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DDE74_RS22655	COG2027	D-alanyl-D-alanine carboxypeptidase
DDE74_RS22665	COG0037	tRNA processing
DDE74_RS22680	COG0302	gtp cyclohydrolase
DDE74_RS22690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DDE74_RS22690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DDE74_RS22705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DDE74_RS22710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DDE74_RS22730	COG0649	NAD binding
DDE74_RS22740	COG4585	Histidine kinase
DDE74_RS22750	COG0640	Transcriptional regulator
DDE74_RS22760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DDE74_RS22770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DDE74_RS22775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DDE74_RS22785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DDE74_RS22805	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DDE74_RS22855	COG2205	protein histidine kinase activity
DDE74_RS22860	COG0745	RESPONSE REGULATOR receiver
DDE74_RS22870	COG1595	DNA-templated transcription, initiation
DDE74_RS22875	COG1194	a g-specific adenine glycosylase
DDE74_RS22890	COG0671	phosphoesterase, PA-phosphatase related
DDE74_RS22935	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DDE74_RS22955	COG0248	Ppx GppA phosphatase
DDE74_RS22960	COG1082	Xylose isomerase domain protein TIM barrel
DDE74_RS22970	COG0129	dihydroxy-acid dehydratase activity
DDE74_RS22980	COG0583	DNA-binding transcription factor activity
DDE74_RS23000	COG0515	serine threonine protein kinase
DDE74_RS23000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDE74_RS23030	COG1252	NADH dehydrogenase
DDE74_RS23050	COG1129	ABC transporter
DDE74_RS23050	COG0842	Transport permease protein
DDE74_RS23060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DDE74_RS23065	COG0180	Tryptophanyl-tRNA synthetase
DDE74_RS23130	COG0739	heme binding
DDE74_RS23130	COG1196	nuclear chromosome segregation
DDE74_RS23130	COG0741	lytic transglycosylase activity
DDE74_RS23135	COG0671	phosphoesterase, PA-phosphatase related
DDE74_RS23140	COG0277	FAD linked oxidase domain protein
DDE74_RS23160	COG1937	Protein conserved in bacteria
DDE74_RS23170	COG0306	phosphate transporter
DDE74_RS23175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DDE74_RS23190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DDE74_RS23230	COG2890	protein-(glutamine-N5) methyltransferase activity
DDE74_RS23245	COG0667	Aldo Keto reductase
DDE74_RS23270	COG1733	regulation of RNA biosynthetic process
DDE74_RS23285	COG0431	NADPH-dependent FMN reductase
DDE74_RS23305	COG1490	D-aminoacyl-tRNA deacylase activity
DDE74_RS23315	COG0735	belongs to the Fur family
DDE74_RS23325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DDE74_RS23330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDE74_RS23335	COG3485	protocatechuate 3,4-dioxygenase
DDE74_RS23355	COG2897	thiosulfate sulfurtransferase activity
DDE74_RS23390	COG0745	RESPONSE REGULATOR receiver
DDE74_RS23395	COG1609	Transcriptional regulator
DDE74_RS23400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDE74_RS23455	COG0737	Belongs to the 5'-nucleotidase family
DDE74_RS23460	COG0456	acetyltransferase
DDE74_RS23470	COG1131	(ABC) transporter
DDE74_RS23480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DDE74_RS23515	COG0667	Aldo Keto reductase
DDE74_RS23530	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS23545	COG0588	phosphoglycerate mutase activity
DDE74_RS23560	COG5002	protein histidine kinase activity
DDE74_RS23580	COG1329	Transcriptional regulator
DDE74_RS23585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DDE74_RS23590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DDE74_RS23595	COG3467	pyridoxamine 5'-phosphate
DDE74_RS23600	COG0215	cysteine-tRNA ligase activity
DDE74_RS23625	COG3842	ATPase activity
DDE74_RS23635	COG2205	protein histidine kinase activity
DDE74_RS23640	COG0745	RESPONSE REGULATOR receiver
DDE74_RS23705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DDE74_RS23730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DDE74_RS23770	COG0463	Glycosyl transferase, family 2
DDE74_RS23785	COG1278	Cold shock
DDE74_RS23790	COG0459	protein refolding
DDE74_RS23810	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DDE74_RS23845	COG3142	Participates in the control of copper homeostasis
DDE74_RS23850	COG3973	AAA domain
DDE74_RS23865	COG1061	Type III restriction enzyme res subunit
DDE74_RS23905	COG1278	Cold shock
DDE74_RS23910	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DDE74_RS23915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DDE74_RS23925	COG2814	Major facilitator Superfamily
DDE74_RS23960	COG0681	Belongs to the peptidase S26 family
DDE74_RS23970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DDE74_RS23985	COG2252	PERMEase
DDE74_RS24000	COG0477	Major facilitator Superfamily
DDE74_RS24010	COG0667	Aldo Keto reductase
DDE74_RS24015	COG2814	Major facilitator Superfamily
DDE74_RS24050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DDE74_RS24055	COG2378	regulation of single-species biofilm formation
DDE74_RS24065	COG0277	FAD linked oxidase domain protein
DDE74_RS24065	COG0247	lactate metabolic process
DDE74_RS24100	COG0583	DNA-binding transcription factor activity
DDE74_RS24105	COG5006	permease, DMT superfamily
DDE74_RS24125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDE74_RS24140	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS24150	COG1309	transcriptional regulator
DDE74_RS24160	COG0259	pyridoxamine-phosphate oxidase activity
DDE74_RS24170	COG4821	SIS domain
DDE74_RS24180	COG2945	thiolester hydrolase activity
DDE74_RS24180	COG0596	Alpha beta hydrolase
DDE74_RS24205	COG1131	(ABC) transporter
DDE74_RS24255	COG4585	Histidine kinase
DDE74_RS24290	COG0515	serine threonine protein kinase
DDE74_RS24295	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS24320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DDE74_RS24320	COG0519	Catalyzes the synthesis of GMP from XMP
DDE74_RS24330	COG0436	Aminotransferase
DDE74_RS24335	COG2423	ornithine cyclodeaminase activity
DDE74_RS24380	COG2815	serine threonine protein kinase
DDE74_RS24380	COG0515	serine threonine protein kinase
DDE74_RS24390	COG2197	response regulator
DDE74_RS24440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDE74_RS24455	COG0714	Associated with various cellular activities
DDE74_RS24460	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DDE74_RS24465	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DDE74_RS24585	COG0045	succinate-CoA ligase (ADP-forming) activity
DDE74_RS24615	COG0138	bifunctional purine biosynthesis protein purh
DDE74_RS24630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DDE74_RS24645	COG0039	L-malate dehydrogenase activity
DDE74_RS24650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DDE74_RS24710	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS24720	COG4175	Glycine betaine
DDE74_RS24720	COG0517	IMP dehydrogenase activity
DDE74_RS24755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDE74_RS24760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDE74_RS24770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDE74_RS24775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDE74_RS24780	COG0456	acetyltransferase
DDE74_RS24795	COG0754	glutathionylspermidine amidase activity
DDE74_RS24815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDE74_RS24820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDE74_RS24830	COG0180	Tryptophanyl-tRNA synthetase
DDE74_RS24840	COG1295	ribonuclease BN
DDE74_RS24845	COG1686	Belongs to the peptidase S11 family
DDE74_RS24855	COG1408	metallophosphoesterase
DDE74_RS24870	COG1404	Belongs to the peptidase S8 family
DDE74_RS24900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DDE74_RS24905	COG1053	succinate dehydrogenase
DDE74_RS24915	COG2009	succinate dehydrogenase
DDE74_RS24930	COG1595	DNA-templated transcription, initiation
DDE74_RS24945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDE74_RS24945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDE74_RS24955	COG2186	Transcriptional regulator
DDE74_RS24960	COG3265	gluconokinase activity
DDE74_RS24990	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DDE74_RS25000	COG1216	Glycosyl transferase, family 2
DDE74_RS25010	COG1083	cytidylyl-transferase
DDE74_RS25015	COG2089	acid synthase
DDE74_RS25025	COG1473	amidohydrolase
DDE74_RS25025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DDE74_RS25030	COG1744	ABC transporter substrate-binding protein PnrA-like
DDE74_RS25035	COG3845	ABC transporter
DDE74_RS25040	COG4603	Belongs to the binding-protein-dependent transport system permease family
DDE74_RS25045	COG1079	Belongs to the binding-protein-dependent transport system permease family
DDE74_RS25120	COG2814	Major facilitator Superfamily
DDE74_RS25125	COG0583	DNA-binding transcription factor activity
DDE74_RS25135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDE74_RS25160	COG2205	protein histidine kinase activity
DDE74_RS25165	COG0745	RESPONSE REGULATOR receiver
DDE74_RS25170	COG1595	DNA-templated transcription, initiation
DDE74_RS25185	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS25190	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS25195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DDE74_RS25205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DDE74_RS25240	COG4770	biotin carboxylase activity
DDE74_RS25250	COG0693	protein deglycase activity
DDE74_RS25260	COG0424	maF-like protein
DDE74_RS25265	COG0768	penicillin binding
DDE74_RS25275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDE74_RS25285	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DDE74_RS25290	COG1024	Enoyl-CoA hydratase
DDE74_RS25300	COG2986	histidine ammonia-lyase
DDE74_RS25315	COG1376	ErfK ybiS ycfS ynhG family protein
DDE74_RS25360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDE74_RS25365	COG2197	response regulator
DDE74_RS25370	COG4585	Histidine kinase
DDE74_RS25450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDE74_RS25470	COG2255	four-way junction helicase activity
DDE74_RS25475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DDE74_RS25490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DDE74_RS25500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DDE74_RS25515	COG1331	Highly conserved protein containing a thioredoxin domain
DDE74_RS25530	COG0789	Transcriptional regulator
DDE74_RS25545	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DDE74_RS25565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DDE74_RS25575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDE74_RS25580	COG1414	Transcriptional regulator
DDE74_RS25585	COG0251	oxidation-reduction process
DDE74_RS25590	COG2610	gluconate transmembrane transporter activity
DDE74_RS25605	COG0124	histidyl-tRNA synthetase
DDE74_RS25700	COG2894	cell division
DDE74_RS25740	COG2885	chlorophyll binding
DDE74_RS25765	COG4974	Belongs to the 'phage' integrase family
DDE74_RS25790	COG0667	Aldo Keto reductase
DDE74_RS25795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DDE74_RS25800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DDE74_RS25815	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDE74_RS25820	COG0450	alkyl hydroperoxide reductase
DDE74_RS25835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DDE74_RS25850	COG1136	(ABC) transporter
DDE74_RS25865	COG1136	(ABC) transporter
DDE74_RS25880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDE74_RS25905	COG0114	fumarate hydratase activity
DDE74_RS25915	COG3345	alpha-galactosidase
DDE74_RS26010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DDE74_RS26010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DDE74_RS26035	COG0778	Nitroreductase
DDE74_RS26040	COG1722	exodeoxyribonuclease VII activity
DDE74_RS26045	COG1570	exodeoxyribonuclease VII activity
DDE74_RS26055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DDE74_RS26065	COG0012	GTP binding
DDE74_RS26070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDE74_RS26075	COG1414	Transcriptional regulator
DDE74_RS26090	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE74_RS26090	COG0596	Alpha beta hydrolase
DDE74_RS26105	COG0531	amino acid
DDE74_RS26140	COG1053	succinate dehydrogenase
DDE74_RS26160	COG1217	gtp-binding protein TYPA
DDE74_RS26170	COG0601	transmembrane transport
DDE74_RS26175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDE74_RS26180	COG0444	Belongs to the ABC transporter superfamily
DDE74_RS26185	COG4608	Belongs to the ABC transporter superfamily
DDE74_RS26190	COG4608	Belongs to the ABC transporter superfamily
DDE74_RS26195	COG0444	Belongs to the ABC transporter superfamily
DDE74_RS26200	COG0601	transmembrane transport
DDE74_RS26205	COG4166	transmembrane transport
DDE74_RS26210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDE74_RS26230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DDE74_RS26280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDE74_RS26285	COG1611	Belongs to the LOG family
DDE74_RS26290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DDE74_RS26300	COG0519	Catalyzes the synthesis of GMP from XMP
DDE74_RS26305	COG1024	Enoyl-CoA hydratase
DDE74_RS26320	COG1595	DNA-templated transcription, initiation
DDE74_RS26330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDE74_RS26335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DDE74_RS26370	COG0598	Magnesium transport protein CorA
DDE74_RS26380	COG2814	Major facilitator Superfamily
DDE74_RS26395	COG2095	MarC family integral membrane protein
DDE74_RS26400	COG1432	Conserved Protein
DDE74_RS26445	COG2267	carboxylic ester hydrolase activity
DDE74_RS26495	COG0210	DNA helicase
DDE74_RS26500	COG0210	DNA helicase
DDE74_RS26505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDE74_RS26545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DDE74_RS26600	COG3480	Lon protease (S16) C-terminal proteolytic domain
DDE74_RS26610	COG1615	UPF0182 protein
DDE74_RS26645	COG0735	belongs to the Fur family
DDE74_RS26650	COG0753	catalase activity
DDE74_RS26660	COG0483	inositol monophosphate 1-phosphatase activity
DDE74_RS26670	COG2076	Multidrug Resistance protein
DDE74_RS26680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DDE74_RS26690	COG2135	peptidase activity
DDE74_RS26700	COG3800	Transcriptional regulator
DDE74_RS26700	COG1396	sequence-specific DNA binding
DDE74_RS26705	COG1595	DNA-templated transcription, initiation
DDE74_RS26710	COG5662	AntiSigma factor
DDE74_RS26730	COG0242	peptide deformylase activity
DDE74_RS26735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDE74_RS26740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDE74_RS26765	COG2188	Transcriptional regulator
DDE74_RS26770	COG2182	Extracellular solute-binding protein
DDE74_RS26775	COG1175	transmembrane transport
DDE74_RS26780	COG0395	ABC-type sugar transport system, permease component
DDE74_RS26785	COG1472	Belongs to the glycosyl hydrolase 3 family
DDE74_RS26790	COG0363	glucosamine-6-phosphate deaminase activity
DDE74_RS26795	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS26800	COG1309	transcriptional regulator
DDE74_RS26815	COG1597	lipid kinase activity
DDE74_RS26850	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DDE74_RS26870	COG2066	Belongs to the glutaminase family
DDE74_RS26885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDE74_RS26900	COG0477	Major facilitator Superfamily
DDE74_RS26910	COG0598	Magnesium transport protein CorA
DDE74_RS26940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DDE74_RS26945	COG1993	acr, cog1993
DDE74_RS26950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DDE74_RS26990	COG2226	methyltransferase
DDE74_RS26995	COG1126	abc transporter atp-binding protein
DDE74_RS27010	COG0281	malic enzyme
DDE74_RS27015	COG0604	alcohol dehydrogenase
DDE74_RS27075	COG2255	four-way junction helicase activity
DDE74_RS27100	COG0567	Dehydrogenase, E1 component
DDE74_RS27100	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE74_RS27105	COG2205	protein histidine kinase activity
DDE74_RS27110	COG0745	RESPONSE REGULATOR receiver
DDE74_RS27135	COG1357	PFAM Pentapeptide repeats (8 copies)
DDE74_RS27140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DDE74_RS27160	COG5002	protein histidine kinase activity
DDE74_RS27205	COG0596	Alpha beta hydrolase
DDE74_RS27215	COG1119	ATPase activity
DDE74_RS27225	COG0768	penicillin binding
DDE74_RS27240	COG2124	cytochrome p450
DDE74_RS27270	COG0018	arginyl-trna synthetase
DDE74_RS27275	COG0019	diaminopimelate decarboxylase activity
DDE74_RS27280	COG0460	homoserine dehydrogenase
DDE74_RS27285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DDE74_RS27290	COG0083	homoserine kinase activity
DDE74_RS27305	COG0254	rRNA binding
DDE74_RS27310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DDE74_RS27315	COG2890	protein-(glutamine-N5) methyltransferase activity
DDE74_RS27325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DDE74_RS27330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDE74_RS27350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDE74_RS27355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DDE74_RS27360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDE74_RS27365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DDE74_RS27370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DDE74_RS27375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DDE74_RS27380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DDE74_RS27390	COG2197	response regulator
DDE74_RS27425	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDE74_RS27440	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DDE74_RS27495	COG0183	Belongs to the thiolase family
DDE74_RS27510	COG0745	RESPONSE REGULATOR receiver
DDE74_RS27515	COG2205	protein histidine kinase activity
DDE74_RS27515	COG2972	Histidine kinase
DDE74_RS27570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDE74_RS27570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDE74_RS27575	COG2205	protein histidine kinase activity
DDE74_RS27580	COG0745	RESPONSE REGULATOR receiver
DDE74_RS27585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DDE74_RS27590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDE74_RS27635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DDE74_RS27640	COG0857	belongs to the CobB CobQ family
DDE74_RS27640	COG0280	phosphate acetyltransferase
DDE74_RS27645	COG0205	6-phosphofructokinase activity
DDE74_RS27650	COG0577	efflux transmembrane transporter activity
DDE74_RS27655	COG1136	(ABC) transporter
DDE74_RS27655	COG0577	efflux transmembrane transporter activity
DDE74_RS27665	COG0395	ABC-type sugar transport system, permease component
DDE74_RS27680	COG4565	transcriptional regulatory protein
DDE74_RS27685	COG3290	protein histidine kinase activity
DDE74_RS27690	COG1301	dicarboxylic acid transport
DDE74_RS27695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DDE74_RS27710	COG0366	Alpha amylase catalytic
DDE74_RS27715	COG4585	Histidine kinase
DDE74_RS27750	COG1132	(ABC) transporter
DDE74_RS27755	COG1132	(ABC) transporter
DDE74_RS27760	COG1132	(ABC) transporter
DDE74_RS27765	COG1132	(ABC) transporter
DDE74_RS27780	COG1376	ErfK ybiS ycfS ynhG family protein
DDE74_RS27800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DDE74_RS27800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DDE74_RS27805	COG0785	Cytochrome C biogenesis protein
DDE74_RS27810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DDE74_RS27820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DDE74_RS27830	COG0438	transferase activity, transferring glycosyl groups
DDE74_RS27835	COG0745	RESPONSE REGULATOR receiver
DDE74_RS27855	COG0671	phosphoesterase, PA-phosphatase related
DDE74_RS27880	COG0515	serine threonine protein kinase
DDE74_RS27925	COG1760	l-serine dehydratase
DDE74_RS27930	COG0531	amino acid
DDE74_RS27935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDE74_RS27940	COG0509	glycine decarboxylation via glycine cleavage system
DDE74_RS27945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DDE74_RS27965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDE74_RS27970	COG0747	negative chemotaxis
DDE74_RS27980	COG0444	Belongs to the ABC transporter superfamily
DDE74_RS27985	COG4608	Belongs to the ABC transporter superfamily
DDE74_RS27995	COG2860	membrane
DDE74_RS28040	COG0482	sulfurtransferase activity
DDE74_RS28070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DDE74_RS28080	COG4221	oxidoreductase activity
DDE74_RS28100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DDE74_RS28115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DDE74_RS28120	COG0154	amidase activity
DDE74_RS28130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DDE74_RS28135	COG0667	Aldo Keto reductase
DDE74_RS28165	COG2409	Drug exporters of the RND superfamily
DDE74_RS28185	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DDE74_RS28185	COG1672	PFAM Archaeal ATPase
DDE74_RS28195	COG2133	pyrroloquinoline quinone binding
DDE74_RS28200	COG0667	Aldo Keto reductase
DDE74_RS28210	COG3300	MHYT domain
DDE74_RS28210	COG5001	Diguanylate cyclase
DDE74_RS28225	COG0440	acetolactate synthase activity
DDE74_RS28230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DDE74_RS28235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDE74_RS28250	COG2226	methyltransferase
DDE74_RS28260	COG0506	proline dehydrogenase activity
DDE74_RS28265	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS28280	COG0473	3-isopropylmalate dehydrogenase activity
DDE74_RS28285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DDE74_RS28295	COG0477	Major facilitator Superfamily
DDE74_RS28305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDE74_RS28310	COG2353	YceI-like domain
DDE74_RS28315	COG5492	domain, Protein
DDE74_RS28320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDE74_RS28345	COG2018	Roadblock/LC7 domain
DDE74_RS28365	COG2018	Roadblock/LC7 domain
DDE74_RS28380	COG0179	Fumarylacetoacetate (FAA) hydrolase
DDE74_RS28385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDE74_RS28430	COG1414	Transcriptional regulator
DDE74_RS28435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DDE74_RS28440	COG0066	3-isopropylmalate dehydratase activity
DDE74_RS28450	COG0776	regulation of translation
DDE74_RS28460	COG1920	GTP binding
DDE74_RS28470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DDE74_RS28475	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDE74_RS28495	COG0351	phosphomethylpyrimidine kinase
DDE74_RS28500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DDE74_RS28505	COG1461	Dihydroxyacetone kinase
DDE74_RS28515	COG0742	ribosomal rna small subunit methyltransferase
DDE74_RS28520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DDE74_RS28535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DDE74_RS28540	COG0571	ribonuclease III activity
DDE74_RS28545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDE74_RS28550	COG1733	regulation of RNA biosynthetic process
DDE74_RS28560	COG2340	Cysteine-rich secretory protein family
DDE74_RS28565	COG1254	Belongs to the acylphosphatase family
DDE74_RS28585	COG0477	Major facilitator Superfamily
DDE74_RS28600	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DDE74_RS28635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DDE74_RS28655	COG0228	four-way junction DNA binding
DDE74_RS28660	COG1837	Belongs to the UPF0109 family
DDE74_RS28665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DDE74_RS28670	COG0336	Belongs to the RNA methyltransferase TrmD family
DDE74_RS28675	COG0335	large ribosomal subunit rRNA binding
DDE74_RS28680	COG0681	Belongs to the peptidase S26 family
DDE74_RS28685	COG0681	Belongs to the peptidase S26 family
DDE74_RS28690	COG0681	Belongs to the peptidase S26 family
DDE74_RS28695	COG0681	Belongs to the peptidase S26 family
DDE74_RS28710	COG0792	nuclease activity
DDE74_RS28725	COG1191	sigma factor activity
DDE74_RS28735	COG4942	peptidase
DDE74_RS28735	COG1388	LysM domain
DDE74_RS28740	COG0052	Belongs to the universal ribosomal protein uS2 family
DDE74_RS28745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DDE74_RS28750	COG0528	UMP kinase activity
DDE74_RS28755	COG0233	cytoplasmic translational termination
DDE74_RS28760	COG0575	Belongs to the CDS family
DDE74_RS28770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DDE74_RS28780	COG4208	sulfate ABC transporter
DDE74_RS28785	COG3842	ATPase activity
DDE74_RS28815	COG4181	ATPase activity
DDE74_RS28820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDE74_RS28830	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS28840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDE74_RS28850	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS28860	COG3842	ATPase activity
DDE74_RS28865	COG1176	ABC-type spermidine putrescine transport system, permease component I
DDE74_RS28870	COG1177	transmembrane transport
DDE74_RS28875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDE74_RS28900	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS28915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DDE74_RS28920	COG0750	zinc metalloprotease
DDE74_RS28925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DDE74_RS28940	COG0442	prolyl-tRNA aminoacylation
DDE74_RS28945	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DDE74_RS28960	COG0779	Required for maturation of 30S ribosomal subunits
DDE74_RS28975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DDE74_RS28985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DDE74_RS28990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DDE74_RS29005	COG0455	bacterial-type flagellum organization
DDE74_RS29020	COG3266	domain, Protein
DDE74_RS29050	COG1404	Belongs to the peptidase S8 family
DDE74_RS29095	COG1674	ftsk spoiiie
DDE74_RS29105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DDE74_RS29110	COG1185	polyribonucleotide nucleotidyltransferase activity
DDE74_RS29115	COG0612	Peptidase, M16
DDE74_RS29120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DDE74_RS29140	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DDE74_RS29145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDE74_RS29150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DDE74_RS29185	COG2208	phosphoserine phosphatase activity
DDE74_RS29185	COG2770	Histidine kinase
DDE74_RS29190	COG3850	Histidine kinase
DDE74_RS29190	COG3437	response regulator, receiver
DDE74_RS29190	COG2205	protein histidine kinase activity
DDE74_RS29190	COG4999	Histidine kinase
DDE74_RS29200	COG1674	ftsk spoiiie
DDE74_RS29210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDE74_RS29220	COG1546	Belongs to the CinA family
DDE74_RS29220	COG1058	Belongs to the CinA family
DDE74_RS29225	COG1396	sequence-specific DNA binding
DDE74_RS29230	COG0783	Belongs to the Dps family
DDE74_RS29240	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS29245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDE74_RS29255	COG1201	RNA secondary structure unwinding
DDE74_RS29315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS29320	COG0765	amino acid transport
DDE74_RS29325	COG0765	amino acid transport
DDE74_RS29330	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DDE74_RS29335	COG1126	abc transporter atp-binding protein
DDE74_RS29340	COG0745	RESPONSE REGULATOR receiver
DDE74_RS29345	COG2205	protein histidine kinase activity
DDE74_RS29350	COG1278	Cold shock
DDE74_RS29360	COG2259	Doxx family
DDE74_RS29365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDE74_RS29380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DDE74_RS29390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DDE74_RS29395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DDE74_RS29405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DDE74_RS29440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DDE74_RS29445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DDE74_RS29450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDE74_RS29460	COG3226	Transcriptional regulator
DDE74_RS29465	COG0154	amidase activity
DDE74_RS29480	COG0488	(ABC) transporter
DDE74_RS29495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DDE74_RS29530	COG2186	Transcriptional regulator
DDE74_RS29535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DDE74_RS29550	COG0187	DNA topoisomerase II activity
DDE74_RS29575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDE74_RS29585	COG4565	transcriptional regulatory protein
DDE74_RS29590	COG3290	protein histidine kinase activity
DDE74_RS29605	COG0372	Belongs to the citrate synthase family
DDE74_RS29615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDE74_RS29620	COG0612	Peptidase, M16
DDE74_RS29635	COG1802	Transcriptional regulator
DDE74_RS29640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDE74_RS29660	COG1435	thymidine kinase activity
DDE74_RS29695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DDE74_RS29700	COG0483	inositol monophosphate 1-phosphatase activity
DDE74_RS29705	COG0745	RESPONSE REGULATOR receiver
DDE74_RS29710	COG2205	protein histidine kinase activity
DDE74_RS29735	COG0756	dUTP diphosphatase activity
DDE74_RS29750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DDE74_RS29755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DDE74_RS29760	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DDE74_RS29765	COG1136	(ABC) transporter
DDE74_RS29800	COG0569	domain protein
DDE74_RS29810	COG0531	amino acid
DDE74_RS29815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDE74_RS29880	COG0515	serine threonine protein kinase
DDE74_RS29880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDE74_RS29990	COG1191	sigma factor activity
DDE74_RS30010	COG1191	sigma factor activity
DDE74_RS30075	COG2367	Beta-lactamase
DDE74_RS30100	COG0598	Magnesium transport protein CorA
DDE74_RS30105	COG1799	cell septum assembly
DDE74_RS30135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DDE74_RS30145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DDE74_RS30150	COG0531	amino acid
DDE74_RS30160	COG1024	Enoyl-CoA hydratase
DDE74_RS30190	COG0546	phosphoglycolate phosphatase activity
DDE74_RS30230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DDE74_RS30245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DDE74_RS30270	COG0443	Heat shock 70 kDa protein
DDE74_RS30285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DDE74_RS30310	COG3480	Lon protease (S16) C-terminal proteolytic domain
DDE74_RS30315	COG1595	DNA-templated transcription, initiation
DDE74_RS30355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DDE74_RS30365	COG1653	transport
DDE74_RS30370	COG1175	transmembrane transport
DDE74_RS30375	COG0395	ABC-type sugar transport system, permease component
DDE74_RS30385	COG4213	ABC transporter substrate-binding protein
DDE74_RS30395	COG4214	carbohydrate transport
DDE74_RS30400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DDE74_RS30405	COG0531	amino acid
DDE74_RS30415	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDE74_RS30415	COG1024	Enoyl-CoA hydratase
DDE74_RS30420	COG0183	Belongs to the thiolase family
DDE74_RS30430	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DDE74_RS30445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DDE74_RS30450	COG0446	pyridine nucleotide-disulphide oxidoreductase
DDE74_RS30455	COG0183	Belongs to the thiolase family
DDE74_RS30465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DDE74_RS30470	COG3253	May function as heme-dependent peroxidase
DDE74_RS30490	COG3220	belongs to the UPF0276 family
DDE74_RS30515	COG1136	(ABC) transporter
DDE74_RS30545	COG0577	efflux transmembrane transporter activity
DDE74_RS30545	COG1136	(ABC) transporter
DDE74_RS30550	COG0577	efflux transmembrane transporter activity
DDE74_RS30560	COG2197	response regulator
DDE74_RS30565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DDE74_RS30570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDE74_RS30590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DDE74_RS30600	COG0693	protein deglycase activity
DDE74_RS30620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDE74_RS30625	COG0583	DNA-binding transcription factor activity
DDE74_RS30665	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS30705	COG0477	Major facilitator Superfamily
DDE74_RS30715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DDE74_RS30720	COG0326	Molecular chaperone. Has ATPase activity
DDE74_RS30740	COG3226	Transcriptional regulator
DDE74_RS30750	COG1309	transcriptional regulator
DDE74_RS30755	COG2409	Drug exporters of the RND superfamily
DDE74_RS30780	COG2318	DinB family
DDE74_RS30805	COG2267	carboxylic ester hydrolase activity
DDE74_RS30815	COG1078	dGTPase activity
DDE74_RS30820	COG1609	Transcriptional regulator
DDE74_RS30840	COG0366	Alpha amylase catalytic
DDE74_RS30855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DDE74_RS30875	COG0529	Catalyzes the synthesis of activated sulfate
DDE74_RS30880	COG0175	sulfate reduction
DDE74_RS30930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDE74_RS30945	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS30970	COG1414	Transcriptional regulator
DDE74_RS30980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DDE74_RS30985	COG3485	protocatechuate 3,4-dioxygenase
DDE74_RS30990	COG3485	protocatechuate 3,4-dioxygenase
DDE74_RS30995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DDE74_RS31000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDE74_RS31055	COG1846	Transcriptional regulator
DDE74_RS31075	COG2080	2 iron, 2 sulfur cluster binding
DDE74_RS31080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DDE74_RS31085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDE74_RS31105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDE74_RS31115	COG4106	trans-aconitate 2-methyltransferase activity
DDE74_RS31120	COG3511	phospholipase C
DDE74_RS31125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DDE74_RS31130	COG0667	Aldo Keto reductase
DDE74_RS31135	COG1376	ErfK ybiS ycfS ynhG family protein
DDE74_RS31160	COG1716	ATPase activity
DDE74_RS31160	COG1131	(ABC) transporter
DDE74_RS31160	COG0842	Transport permease protein
DDE74_RS31165	COG2233	PERMEase
DDE74_RS31175	COG1215	transferase activity, transferring glycosyl groups
DDE74_RS31180	COG2755	lipolytic protein G-D-S-L family
DDE74_RS31180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DDE74_RS31250	COG2318	DinB family
DDE74_RS31255	COG1162	GTPase activity
DDE74_RS31275	COG0028	Belongs to the TPP enzyme family
DDE74_RS31280	COG3415	Transposase
DDE74_RS31280	COG2801	Transposase and inactivated derivatives
DDE74_RS31285	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DDE74_RS31335	COG3409	Peptidoglycan-binding domain 1 protein
DDE74_RS31355	COG1802	Transcriptional regulator
DDE74_RS31385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDE74_RS31390	COG2252	PERMEase
DDE74_RS31400	COG4552	Acetyltransferase involved in intracellular survival and related
DDE74_RS31405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDE74_RS31420	COG2197	response regulator
DDE74_RS31425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DDE74_RS31430	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS31450	COG0515	serine threonine protein kinase
DDE74_RS31495	COG1674	ftsk spoiiie
DDE74_RS31610	COG1652	LysM domain
DDE74_RS31625	COG2255	four-way junction helicase activity
DDE74_RS31665	COG4974	Belongs to the 'phage' integrase family
DDE74_RS31675	COG2226	methyltransferase
DDE74_RS31695	COG0791	NLP P60 protein
DDE74_RS31750	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS31755	COG2315	Protein conserved in bacteria
DDE74_RS31775	COG1136	(ABC) transporter
DDE74_RS31775	COG0577	efflux transmembrane transporter activity
DDE74_RS31780	COG1136	(ABC) transporter
DDE74_RS31780	COG0577	efflux transmembrane transporter activity
DDE74_RS31785	COG2205	protein histidine kinase activity
DDE74_RS31790	COG0745	RESPONSE REGULATOR receiver
DDE74_RS31815	COG0753	catalase activity
DDE74_RS31820	COG2084	Dehydrogenase
DDE74_RS31825	COG3622	Belongs to the hyi family
DDE74_RS31845	COG2351	hydroxyisourate hydrolase activity
DDE74_RS31880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDE74_RS31885	COG1473	amidohydrolase
DDE74_RS31895	COG0174	glutamine synthetase
DDE74_RS31910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DDE74_RS31935	COG1414	Transcriptional regulator
DDE74_RS31945	COG1953	Uracil, thiamine, allantoin
DDE74_RS31950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDE74_RS31955	COG4266	Belongs to the allantoicase family
DDE74_RS31965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DDE74_RS31965	COG3291	Pkd domain containing protein
DDE74_RS31990	COG0800	Aldolase
DDE74_RS32010	COG2188	Transcriptional regulator
DDE74_RS32025	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDE74_RS32035	COG1940	carbohydrate kinase activity
DDE74_RS32050	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS32080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS32160	COG2124	cytochrome p450
DDE74_RS32175	COG3903	Transcriptional regulator
DDE74_RS32175	COG2197	response regulator
DDE74_RS32180	COG3340	Belongs to the peptidase S51 family
DDE74_RS32185	COG0655	NAD(P)H dehydrogenase (quinone) activity
DDE74_RS32195	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS32205	COG1309	transcriptional regulator
DDE74_RS32215	COG0829	nickel cation binding
DDE74_RS32220	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DDE74_RS32230	COG0804	urea catabolic process
DDE74_RS32235	COG0832	Belongs to the urease beta subunit family
DDE74_RS32235	COG0831	urea catabolic process
DDE74_RS32260	COG1755	Isoprenylcysteine carboxyl methyltransferase
DDE74_RS32280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDE74_RS32325	COG0076	glutamate decarboxylase activity
DDE74_RS32345	COG1733	regulation of RNA biosynthetic process
DDE74_RS32360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDE74_RS32385	COG2345	Transcriptional regulator
DDE74_RS32420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DDE74_RS32425	COG0673	inositol 2-dehydrogenase activity
DDE74_RS32430	COG0667	Aldo Keto reductase
DDE74_RS32435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDE74_RS32440	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DDE74_RS32475	COG1595	DNA-templated transcription, initiation
DDE74_RS32480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDE74_RS32500	COG3387	PFAM Glycoside hydrolase 15-related
DDE74_RS32505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DDE74_RS32505	COG2124	cytochrome p450
DDE74_RS32535	COG2197	response regulator
DDE74_RS32545	COG0726	polysaccharide deacetylase
DDE74_RS32550	COG4585	Histidine kinase
DDE74_RS32555	COG2197	response regulator
DDE74_RS32560	COG0300	oxidoreductase activity
DDE74_RS32630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DDE74_RS32670	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS32700	COG0672	)-iron permease
DDE74_RS32765	COG1131	(ABC) transporter
DDE74_RS32835	COG0583	DNA-binding transcription factor activity
DDE74_RS32895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDE74_RS32900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DDE74_RS32925	COG1126	abc transporter atp-binding protein
DDE74_RS32930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDE74_RS32935	COG0765	amino acid transport
DDE74_RS32940	COG0765	amino acid transport
DDE74_RS32955	COG2267	carboxylic ester hydrolase activity
DDE74_RS32960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDE74_RS32970	COG0435	Glutathione S-transferase
DDE74_RS32980	COG2409	Drug exporters of the RND superfamily
DDE74_RS32990	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS33000	COG0531	amino acid
DDE74_RS33010	COG0405	Gamma-glutamyltransferase
DDE74_RS33025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DDE74_RS33035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDE74_RS33040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDE74_RS33065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDE74_RS33070	COG0095	Lipoate-protein ligase
DDE74_RS33075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DDE74_RS33090	COG0483	inositol monophosphate 1-phosphatase activity
DDE74_RS33145	COG1929	Belongs to the glycerate kinase type-1 family
DDE74_RS33155	COG0688	phosphatidylethanolamine metabolic process
DDE74_RS33160	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS33170	COG2301	Belongs to the HpcH HpaI aldolase family
DDE74_RS33175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDE74_RS33175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDE74_RS33190	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDE74_RS33200	COG0456	acetyltransferase
DDE74_RS33200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDE74_RS33225	COG2814	Major facilitator Superfamily
DDE74_RS33250	COG2362	D-Aminopeptidase
DDE74_RS33255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDE74_RS33260	COG0823	Involved in the tonB-independent uptake of proteins
DDE74_RS33260	COG1506	peptidase
DDE74_RS33260	COG4946	Tricorn protease homolog
DDE74_RS33265	COG1619	proteins homologs of microcin C7 resistance protein MccF
DDE74_RS33280	COG2124	cytochrome p450
DDE74_RS33295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDE74_RS33315	COG0010	Belongs to the arginase family
DDE74_RS33335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDE74_RS33350	COG2226	methyltransferase
DDE74_RS33355	COG1597	lipid kinase activity
DDE74_RS33390	COG0531	amino acid
DDE74_RS33445	COG2154	pterin-4-alpha-carbinolamine dehydratase
DDE74_RS33450	COG1295	ribonuclease BN
DDE74_RS33465	COG4106	trans-aconitate 2-methyltransferase activity
DDE74_RS33475	COG0656	L-ascorbic acid biosynthetic process
DDE74_RS33490	COG0583	DNA-binding transcription factor activity
DDE74_RS33505	COG0604	alcohol dehydrogenase
DDE74_RS33515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DDE74_RS33520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS33525	COG0287	Prephenate dehydrogenase
DDE74_RS33525	COG1605	Chorismate mutase
DDE74_RS33530	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS33555	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS33580	COG1309	transcriptional regulator
DDE74_RS33605	COG0583	DNA-binding transcription factor activity
DDE74_RS33640	COG2205	protein histidine kinase activity
DDE74_RS33645	COG0745	RESPONSE REGULATOR receiver
DDE74_RS33670	COG3226	Transcriptional regulator
DDE74_RS33685	COG1846	Transcriptional regulator
DDE74_RS33690	COG1289	transmembrane transporter activity
DDE74_RS33695	COG1309	transcriptional regulator
DDE74_RS33715	COG1349	DNA-binding transcription factor activity
DDE74_RS33725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDE74_RS33730	COG2814	Major facilitator Superfamily
DDE74_RS33745	COG1515	deoxyribonuclease V activity
DDE74_RS33750	COG3268	Saccharopine dehydrogenase
DDE74_RS33765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDE74_RS33775	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS33780	COG0183	Belongs to the thiolase family
DDE74_RS33785	COG1024	Enoyl-CoA hydratase
DDE74_RS33785	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDE74_RS33795	COG1113	amino acid transport
DDE74_RS33815	COG3568	Endonuclease Exonuclease Phosphatase
DDE74_RS33840	COG2936	dipeptidyl-peptidase activity
DDE74_RS33850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DDE74_RS33890	COG2183	response to ionizing radiation
DDE74_RS33900	COG4977	sequence-specific DNA binding
DDE74_RS33910	COG1024	Enoyl-CoA hydratase
DDE74_RS33930	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DDE74_RS33965	COG1134	teichoic acid transport
DDE74_RS33970	COG1562	ergosterol biosynthetic process
DDE74_RS33980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DDE74_RS33990	COG1657	PFAM Prenyltransferase squalene oxidase
DDE74_RS34005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DDE74_RS34020	COG2365	Tyrosine phosphatase family
DDE74_RS34025	COG2755	lipolytic protein G-D-S-L family
DDE74_RS34050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDE74_RS34100	COG2018	Roadblock/LC7 domain
DDE74_RS34120	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS34145	COG2267	carboxylic ester hydrolase activity
DDE74_RS34150	COG3958	Transketolase
DDE74_RS34155	COG3959	Transketolase, thiamine diphosphate binding domain
DDE74_RS34205	COG2124	cytochrome p450
DDE74_RS34210	COG1686	Belongs to the peptidase S11 family
DDE74_RS34230	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDE74_RS34235	COG3246	L-lysine catabolic process to acetate
DDE74_RS34250	COG0174	glutamine synthetase
DDE74_RS34255	COG0477	Major facilitator Superfamily
DDE74_RS34360	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS34375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDE74_RS34380	COG2706	6-phosphogluconolactonase activity
DDE74_RS34400	COG2133	pyrroloquinoline quinone binding
DDE74_RS34400	COG5183	chlorophyll binding
DDE74_RS34480	COG3537	Alpha-1,2-mannosidase
DDE74_RS34490	COG1309	transcriptional regulator
DDE74_RS34510	COG0583	DNA-binding transcription factor activity
DDE74_RS34535	COG0531	amino acid
DDE74_RS34540	COG3360	Dodecin
DDE74_RS34590	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DDE74_RS34600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DDE74_RS34605	COG3572	ergothioneine biosynthetic process
DDE74_RS34625	COG3858	chitin binding
DDE74_RS34625	COG1388	LysM domain
DDE74_RS34640	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS34645	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS34650	COG3415	Transposase
DDE74_RS34650	COG2801	Transposase and inactivated derivatives
DDE74_RS34685	COG0445	tRNA wobble uridine modification
DDE74_RS34725	COG0596	Alpha beta hydrolase
DDE74_RS34730	COG1819	glycosyl
DDE74_RS34745	COG3511	phospholipase C
DDE74_RS34750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DDE74_RS34750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DDE74_RS34775	COG3023	N-Acetylmuramoyl-L-alanine amidase
DDE74_RS34780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDE74_RS34780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDE74_RS34785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDE74_RS34795	COG1070	Carbohydrate kinase
DDE74_RS34805	COG3458	cephalosporin-C deacetylase activity
DDE74_RS34820	COG0765	amino acid transport
DDE74_RS34825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDE74_RS34830	COG2040	homocysteine
DDE74_RS34845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DDE74_RS34870	COG4106	trans-aconitate 2-methyltransferase activity
DDE74_RS34885	COG2018	Roadblock/LC7 domain
DDE74_RS34895	COG1946	Acyl-CoA thioesterase
DDE74_RS34915	COG1132	(ABC) transporter
DDE74_RS34920	COG1132	(ABC) transporter
DDE74_RS34955	COG1132	(ABC) transporter
DDE74_RS34975	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS34980	COG0300	oxidoreductase activity
DDE74_RS35035	COG0247	lactate metabolic process
DDE74_RS35040	COG0477	Major facilitator Superfamily
DDE74_RS35055	COG2018	Roadblock/LC7 domain
DDE74_RS35070	COG2072	flavoprotein involved in K transport
DDE74_RS35085	COG1116	anion transmembrane transporter activity
DDE74_RS35090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DDE74_RS35150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DDE74_RS35150	COG2124	cytochrome p450
DDE74_RS35185	COG1280	lysine exporter protein (LysE YggA)
DDE74_RS35235	COG4172	Belongs to the ABC transporter superfamily
DDE74_RS35240	COG4171	peptide transport system, permease
DDE74_RS35245	COG0601	transmembrane transport
DDE74_RS35250	COG4166	transmembrane transport
DDE74_RS35265	COG0019	diaminopimelate decarboxylase activity
DDE74_RS35270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDE74_RS35275	COG0534	Mate efflux family protein
DDE74_RS35290	COG0306	phosphate transporter
DDE74_RS35305	COG0667	Aldo Keto reductase
DDE74_RS35350	COG2207	Transcriptional regulator
DDE74_RS35370	COG1902	pentaerythritol trinitrate reductase activity
DDE74_RS35390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS35435	COG2070	2-Nitropropane dioxygenase
DDE74_RS35440	COG3291	Pkd domain containing protein
DDE74_RS35445	COG0583	DNA-binding transcription factor activity
DDE74_RS35465	COG2018	Roadblock/LC7 domain
DDE74_RS35500	COG2197	response regulator
DDE74_RS35590	COG2267	carboxylic ester hydrolase activity
DDE74_RS35600	COG1254	Belongs to the acylphosphatase family
DDE74_RS35620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DDE74_RS35630	COG2271	Major facilitator Superfamily
DDE74_RS35635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DDE74_RS35640	COG1304	FMN binding
DDE74_RS35660	COG0300	oxidoreductase activity
DDE74_RS35665	COG4213	ABC transporter substrate-binding protein
DDE74_RS35670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDE74_RS35685	COG2706	6-phosphogluconolactonase activity
DDE74_RS35715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DDE74_RS35725	COG1902	pentaerythritol trinitrate reductase activity
DDE74_RS35775	COG1113	amino acid transport
DDE74_RS35780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDE74_RS35800	COG1252	NADH dehydrogenase
DDE74_RS35825	COG0477	Major facilitator Superfamily
DDE74_RS35830	COG1957	nucleoside hydrolase
DDE74_RS35835	COG1609	Transcriptional regulator
DDE74_RS35895	COG2205	protein histidine kinase activity
DDE74_RS35910	COG3961	Belongs to the TPP enzyme family
DDE74_RS35915	COG1231	oxidoreductase activity
DDE74_RS35990	COG1733	regulation of RNA biosynthetic process
DDE74_RS36010	COG1309	transcriptional regulator
DDE74_RS36020	COG1051	belongs to the nudix hydrolase family
DDE74_RS36030	COG0302	gtp cyclohydrolase
DDE74_RS36035	COG3548	integral membrane protein
DDE74_RS36095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DDE74_RS36110	COG3693	PFAM glycoside hydrolase, family 10
DDE74_RS36120	COG3344	reverse transcriptase
DDE74_RS36130	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS36145	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS36175	COG1228	amidohydrolase
DDE74_RS36185	COG1216	Glycosyl transferase, family 2
DDE74_RS36205	COG2364	Membrane
DDE74_RS36225	COG3012	SEC-C Motif Domain Protein
DDE74_RS36235	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DDE74_RS36240	COG3285	dna ligase
DDE74_RS36240	COG1793	dna ligase
DDE74_RS36250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DDE74_RS36260	COG2356	endonuclease I
DDE74_RS36270	COG1278	Cold shock
DDE74_RS36305	COG0395	ABC-type sugar transport system, permease component
DDE74_RS36310	COG1175	transmembrane transport
DDE74_RS36320	COG1609	Transcriptional regulator
DDE74_RS36325	COG0702	epimerase
DDE74_RS36330	COG0739	heme binding
DDE74_RS36380	COG1846	Transcriptional regulator
DDE74_RS36385	COG1764	response to oxidative stress
DDE74_RS36395	COG0395	ABC-type sugar transport system, permease component
DDE74_RS36400	COG1175	transmembrane transport
DDE74_RS36410	COG1940	carbohydrate kinase activity
DDE74_RS36430	COG2770	Histidine kinase
DDE74_RS36430	COG2208	phosphoserine phosphatase activity
DDE74_RS36470	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS36475	COG1968	undecaprenyl-diphosphatase activity
DDE74_RS36490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DDE74_RS36545	COG2018	Roadblock/LC7 domain
DDE74_RS36560	COG2124	cytochrome p450
DDE74_RS36565	COG2124	cytochrome p450
DDE74_RS36580	COG0110	maltose O-acetyltransferase activity
DDE74_RS36605	COG1832	CoA-binding protein
DDE74_RS36615	COG1739	Uncharacterized protein family UPF0029
DDE74_RS36620	COG0531	amino acid
DDE74_RS36630	COG1136	(ABC) transporter
DDE74_RS36630	COG0577	efflux transmembrane transporter activity
DDE74_RS36640	COG2197	response regulator
DDE74_RS36645	COG0596	Alpha beta hydrolase
DDE74_RS36680	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DDE74_RS36710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDE74_RS36785	COG1309	transcriptional regulator
DDE74_RS36835	COG0420	3'-5' exonuclease activity
DDE74_RS36840	COG0419	ATPase involved in DNA repair
DDE74_RS36850	COG2378	regulation of single-species biofilm formation
DDE74_RS36860	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS36885	COG2267	carboxylic ester hydrolase activity
DDE74_RS36890	COG1595	DNA-templated transcription, initiation
DDE74_RS36900	COG2188	Transcriptional regulator
DDE74_RS36905	COG1940	carbohydrate kinase activity
DDE74_RS36910	COG2197	response regulator
DDE74_RS36915	COG4585	Histidine kinase
DDE74_RS36945	COG3511	phospholipase C
DDE74_RS36950	COG3663	DNA glycosylase
DDE74_RS36955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DDE74_RS37005	COG0697	spore germination
DDE74_RS37010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DDE74_RS37030	COG2226	methyltransferase
DDE74_RS37035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DDE74_RS37040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDE74_RS37045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DDE74_RS37060	COG0583	DNA-binding transcription factor activity
DDE74_RS37065	COG1280	lysine exporter protein (LysE YggA)
DDE74_RS37080	COG0740	serine-type endopeptidase activity
DDE74_RS37175	COG1309	transcriptional regulator
DDE74_RS37190	COG0655	NAD(P)H dehydrogenase (quinone) activity
DDE74_RS37210	COG3415	Transposase
DDE74_RS37210	COG2801	Transposase and inactivated derivatives
DDE74_RS37220	COG1414	Transcriptional regulator
DDE74_RS37225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDE74_RS37240	COG2234	aminopeptidase activity
DDE74_RS37240	COG4935	Belongs to the peptidase S8 family
DDE74_RS37245	COG0831	urea catabolic process
DDE74_RS37250	COG0832	Belongs to the urease beta subunit family
DDE74_RS37255	COG0804	urea catabolic process
DDE74_RS37260	COG0830	nickel cation binding
DDE74_RS37265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DDE74_RS37270	COG0829	nickel cation binding
DDE74_RS37300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DDE74_RS37335	COG3336	cytochrome c oxidase
DDE74_RS37340	COG0205	6-phosphofructokinase activity
DDE74_RS37345	COG3442	glutamine amidotransferase
DDE74_RS37355	COG0242	peptide deformylase activity
DDE74_RS37365	COG1960	acyl-CoA dehydrogenase activity
DDE74_RS37400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DDE74_RS37405	COG3960	tartronate-semialdehyde synthase activity
DDE74_RS37410	COG2084	Dehydrogenase
DDE74_RS37440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DDE74_RS37445	COG1028	Short-chain dehydrogenase reductase Sdr
DDE74_RS37465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDE74_RS37475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDE74_RS37490	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DDE74_RS37520	COG0375	protein maturation
DDE74_RS37525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DDE74_RS37530	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DDE74_RS37535	COG0298	carbon dioxide binding
DDE74_RS37545	COG0309	Hydrogenase expression formation protein (HypE)
DDE74_RS37560	COG0531	amino acid
DDE74_RS37575	COG1793	dna ligase
DDE74_RS37610	COG0318	PFAM AMP-dependent synthetase and ligase
DDE74_RS37630	COG3290	protein histidine kinase activity
DDE74_RS37640	COG1349	DNA-binding transcription factor activity
DDE74_RS37670	COG2124	cytochrome p450
DDE74_RS37770	COG1846	Transcriptional regulator
DDE74_RS37785	COG0583	DNA-binding transcription factor activity
DDE74_RS37795	COG0339	signal peptide processing
DDE74_RS37805	COG1652	LysM domain
DDE74_RS37840	COG4221	oxidoreductase activity
DDE74_RS37910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDE74_RS37910	COG0574	Belongs to the PEP-utilizing enzyme family
DDE74_RS37915	COG0151	Belongs to the GarS family
DDE74_RS37920	COG2197	response regulator
DDE74_RS37940	COG2301	Belongs to the HpcH HpaI aldolase family
DDE74_RS37980	COG0297	glycogen (starch) synthase activity
DDE74_RS37990	COG0110	maltose O-acetyltransferase activity
DDE74_RS37995	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DDE74_RS38000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDE74_RS38005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DDE74_RS38020	COG0328	RNA-DNA hybrid ribonuclease activity
DDE74_RS38060	COG2197	response regulator
DDE74_RS38065	COG4585	Histidine kinase
DDE74_RS38085	COG2072	flavoprotein involved in K transport
DDE74_RS38095	COG2208	phosphoserine phosphatase activity
DDE74_RS38140	COG0583	DNA-binding transcription factor activity
DDE74_RS38145	COG0596	Alpha beta hydrolase
DDE74_RS38145	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE74_RS38180	COG0738	Major facilitator superfamily
DDE74_RS38190	COG0477	Major facilitator Superfamily
DDE74_RS38195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDE74_RS38200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDE74_RS38205	COG0142	geranyltranstransferase activity
DDE74_RS38240	COG1595	DNA-templated transcription, initiation
DDE74_RS38280	COG2080	2 iron, 2 sulfur cluster binding
DDE74_RS38285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DDE74_RS38290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDE74_RS38295	COG0431	NADPH-dependent FMN reductase
DDE74_RS38325	COG0583	DNA-binding transcription factor activity
DDE74_RS38340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DDE74_RS38340	COG1017	nitric oxide dioxygenase activity
DDE74_RS38345	COG1959	2 iron, 2 sulfur cluster binding
DDE74_RS38375	COG0537	adenosine 5'-monophosphoramidase activity
DDE74_RS38385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DDE74_RS38405	COG0277	FAD linked oxidase domain protein
DDE74_RS38405	COG0247	lactate metabolic process
DDE74_RS38410	COG0583	DNA-binding transcription factor activity
DDE74_RS38415	COG0531	amino acid
DDE74_RS38420	COG0583	DNA-binding transcription factor activity
DDE74_RS38455	COG2208	phosphoserine phosphatase activity
DDE74_RS38455	COG2770	Histidine kinase
DDE74_RS38465	COG4257	antibiotic catabolic process
DDE74_RS38470	COG1191	sigma factor activity
DDE74_RS38510	COG1819	glycosyl
DDE74_RS38580	COG1132	(ABC) transporter
DDE74_RS38610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDE74_RS38635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDE74_RS38640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDE74_RS38640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDE74_RS38685	COG4585	Histidine kinase
DDE74_RS38710	COG3979	chitinase
DDE74_RS38720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDE74_RS38740	COG3938	Belongs to the proline racemase family
DDE74_RS38745	COG1012	belongs to the aldehyde dehydrogenase family
DDE74_RS38750	COG1802	Transcriptional regulator
DDE74_RS38775	COG1063	alcohol dehydrogenase
DDE74_RS38855	COG0789	Transcriptional regulator
DDE74_RS38880	COG1231	oxidoreductase activity
DDE74_RS38905	COG2318	DinB family
DDE74_RS38910	COG2813	Specifically methylates the guanine in position
DDE74_RS38915	COG1396	sequence-specific DNA binding
DDE74_RS38920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DDE74_RS38925	COG0753	catalase activity
DDE74_RS38960	COG1733	regulation of RNA biosynthetic process
DDE74_RS38975	COG1595	DNA-templated transcription, initiation
DDE74_RS38995	COG3344	reverse transcriptase
DDE74_RS39010	COG0587	DNA-directed DNA polymerase activity
DDE74_RS39035	COG1733	regulation of RNA biosynthetic process
DDE74_RS39060	COG2814	Major facilitator Superfamily
DDE74_RS39115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DDE74_RS39225	COG0137	argininosuccinate synthase activity
DDE74_RS39235	COG5650	phosphatidylinositol metabolic process
DDE74_RS39240	COG0463	Glycosyl transferase, family 2
DDE74_RS39255	COG2124	cytochrome p450
DDE74_RS39270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDE74_RS39280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DDE74_RS39300	COG0640	Transcriptional regulator
DDE74_RS39345	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DDE74_RS39365	COG5002	protein histidine kinase activity
DDE74_RS39365	COG0784	Response regulator, receiver
DDE74_RS39365	COG2205	protein histidine kinase activity
DDE74_RS39370	COG0784	Response regulator, receiver
DDE74_RS39370	COG5002	protein histidine kinase activity
DDE74_RS39370	COG2205	protein histidine kinase activity
DDE74_RS39370	COG2205	protein histidine kinase activity
DDE74_RS39370	COG0784	Response regulator, receiver
DDE74_RS39370	COG5002	protein histidine kinase activity
DDE74_RS39480	COG0831	urea catabolic process
DDE74_RS39485	COG0832	Belongs to the urease beta subunit family
DDE74_RS39490	COG0804	urea catabolic process
DDE74_RS39500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DDE74_RS39505	COG0829	nickel cation binding
DDE74_RS39610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DDE74_RS39700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDE74_RS39835	COG3903	Transcriptional regulator
DDE74_RS39835	COG3629	intracellular signal transduction