locus-tag	class	description
SMALA_RS00085	COG1573	uracil-dna glycosylase
SMALA_RS00090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMALA_RS00100	COG0163	prenyltransferase activity
SMALA_RS00105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMALA_RS00110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMALA_RS00200	COG0583	DNA-binding transcription factor activity
SMALA_RS00210	COG2084	Dehydrogenase
SMALA_RS00215	COG3395	kinase activity
SMALA_RS00220	COG2271	Major facilitator Superfamily
SMALA_RS00225	COG3622	Belongs to the hyi family
SMALA_RS00230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMALA_RS00235	COG2186	Transcriptional regulator
SMALA_RS00245	COG2318	DinB family
SMALA_RS00250	COG0667	Aldo Keto reductase
SMALA_RS00265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMALA_RS00300	COG1959	2 iron, 2 sulfur cluster binding
SMALA_RS00305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMALA_RS00305	COG1017	nitric oxide dioxygenase activity
SMALA_RS00310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SMALA_RS00320	COG0789	Transcriptional regulator
SMALA_RS00330	COG0667	Aldo Keto reductase
SMALA_RS00365	COG0477	Major facilitator Superfamily
SMALA_RS00390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMALA_RS00400	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMALA_RS00435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMALA_RS00485	COG1982	Orn Lys Arg decarboxylase major
SMALA_RS00510	COG2080	2 iron, 2 sulfur cluster binding
SMALA_RS00515	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMALA_RS00520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS00565	COG0328	RNA-DNA hybrid ribonuclease activity
SMALA_RS00570	COG2356	endonuclease I
SMALA_RS00620	COG1051	belongs to the nudix hydrolase family
SMALA_RS00645	COG3511	phospholipase C
SMALA_RS00675	COG1131	(ABC) transporter
SMALA_RS00710	COG1357	PFAM Pentapeptide repeats (8 copies)
SMALA_RS00720	COG0306	phosphate transporter
SMALA_RS00735	COG0583	DNA-binding transcription factor activity
SMALA_RS00740	COG2175	clavaminate synthase activity
SMALA_RS00745	COG3903	Transcriptional regulator
SMALA_RS00745	COG3629	intracellular signal transduction
SMALA_RS00760	COG2267	carboxylic ester hydrolase activity
SMALA_RS00770	COG0114	fumarate hydratase activity
SMALA_RS00775	COG0726	polysaccharide deacetylase
SMALA_RS00790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMALA_RS00795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMALA_RS00800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS00810	COG3290	protein histidine kinase activity
SMALA_RS00815	COG4565	transcriptional regulatory protein
SMALA_RS00825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMALA_RS00845	COG1309	transcriptional regulator
SMALA_RS00855	COG4221	oxidoreductase activity
SMALA_RS00860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SMALA_RS00865	COG2376	Dihydroxyacetone kinase
SMALA_RS00870	COG2376	Dihydroxyacetone kinase
SMALA_RS00875	COG3594	Acyltransferase
SMALA_RS00935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS00945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS00950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMALA_RS00955	COG2080	2 iron, 2 sulfur cluster binding
SMALA_RS00960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMALA_RS01000	COG0515	serine threonine protein kinase
SMALA_RS01000	COG2815	serine threonine protein kinase
SMALA_RS01030	COG0412	Dienelactone hydrolase
SMALA_RS01050	COG0326	Molecular chaperone. Has ATPase activity
SMALA_RS01075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMALA_RS01100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMALA_RS01110	COG2508	Transcriptional regulator
SMALA_RS01120	COG0739	heme binding
SMALA_RS01130	COG2175	clavaminate synthase activity
SMALA_RS01135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS01150	COG0142	geranyltranstransferase activity
SMALA_RS01155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMALA_RS01175	COG2814	Major facilitator Superfamily
SMALA_RS01180	COG0668	transmembrane transport
SMALA_RS01185	COG2197	response regulator
SMALA_RS01215	COG3387	PFAM Glycoside hydrolase 15-related
SMALA_RS01220	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SMALA_RS01235	COG3537	Alpha-1,2-mannosidase
SMALA_RS01250	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS01255	COG2610	gluconate transmembrane transporter activity
SMALA_RS01280	COG1414	Transcriptional regulator
SMALA_RS01285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMALA_RS01295	COG1968	undecaprenyl-diphosphatase activity
SMALA_RS01300	COG1902	pentaerythritol trinitrate reductase activity
SMALA_RS01320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMALA_RS01330	COG4221	oxidoreductase activity
SMALA_RS01405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMALA_RS01405	COG3291	Pkd domain containing protein
SMALA_RS01430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMALA_RS01445	COG1064	alcohol dehydrogenase
SMALA_RS01455	COG2340	Cysteine-rich secretory protein family
SMALA_RS01465	COG0477	Major facilitator Superfamily
SMALA_RS01490	COG0435	Glutathione S-transferase
SMALA_RS01515	COG1472	Belongs to the glycosyl hydrolase 3 family
SMALA_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS01530	COG0701	Predicted permease
SMALA_RS01540	COG1819	glycosyl
SMALA_RS01565	COG0488	(ABC) transporter
SMALA_RS01580	COG0656	L-ascorbic acid biosynthetic process
SMALA_RS01600	COG3321	synthase
SMALA_RS01600	COG0604	alcohol dehydrogenase
SMALA_RS01625	COG0156	8-amino-7-oxononanoate synthase activity
SMALA_RS01635	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS01640	COG3509	depolymerase
SMALA_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS01680	COG3835	regulator
SMALA_RS01685	COG2226	methyltransferase
SMALA_RS01695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMALA_RS01705	COG2271	Major facilitator Superfamily
SMALA_RS01745	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS01750	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS01755	COG0129	dihydroxy-acid dehydratase activity
SMALA_RS01770	COG0701	Predicted permease
SMALA_RS01775	COG0673	inositol 2-dehydrogenase activity
SMALA_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS01815	COG0492	ferredoxin-NADP+ reductase activity
SMALA_RS01830	COG0475	glutathione-regulated potassium exporter activity
SMALA_RS01835	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS01845	COG2197	response regulator
SMALA_RS01870	COG1309	transcriptional regulator
SMALA_RS01880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMALA_RS01895	COG0531	amino acid
SMALA_RS01920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMALA_RS01945	COG3119	arylsulfatase activity
SMALA_RS01970	COG1175	transmembrane transport
SMALA_RS01975	COG0395	ABC-type sugar transport system, permease component
SMALA_RS01980	COG1609	Transcriptional regulator
SMALA_RS01990	COG0673	inositol 2-dehydrogenase activity
SMALA_RS02015	COG2197	response regulator
SMALA_RS02025	COG0577	efflux transmembrane transporter activity
SMALA_RS02030	COG1271	oxidase subunit
SMALA_RS02035	COG1294	oxidase, subunit
SMALA_RS02045	COG2815	serine threonine protein kinase
SMALA_RS02045	COG0515	serine threonine protein kinase
SMALA_RS02050	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMALA_RS02105	COG0431	NADPH-dependent FMN reductase
SMALA_RS02125	COG4977	sequence-specific DNA binding
SMALA_RS02130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMALA_RS02165	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMALA_RS02175	COG5001	Diguanylate cyclase
SMALA_RS02175	COG3300	MHYT domain
SMALA_RS02205	COG0542	response to heat
SMALA_RS02215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMALA_RS02215	COG0515	serine threonine protein kinase
SMALA_RS02250	COG0789	Transcriptional regulator
SMALA_RS02260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMALA_RS02275	COG0546	phosphoglycolate phosphatase activity
SMALA_RS02305	COG3290	protein histidine kinase activity
SMALA_RS02315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMALA_RS02340	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SMALA_RS02355	COG3321	synthase
SMALA_RS02355	COG0604	alcohol dehydrogenase
SMALA_RS02365	COG3321	synthase
SMALA_RS02365	COG0604	alcohol dehydrogenase
SMALA_RS02370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS02375	COG2197	response regulator
SMALA_RS02380	COG0778	Nitroreductase
SMALA_RS02385	COG1063	alcohol dehydrogenase
SMALA_RS02395	COG2072	flavoprotein involved in K transport
SMALA_RS02410	COG1053	succinate dehydrogenase
SMALA_RS02415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMALA_RS02460	COG0583	DNA-binding transcription factor activity
SMALA_RS02470	COG0789	Transcriptional regulator
SMALA_RS02475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMALA_RS02485	COG5006	permease, DMT superfamily
SMALA_RS02505	COG3467	pyridoxamine 5'-phosphate
SMALA_RS02540	COG0587	DNA-directed DNA polymerase activity
SMALA_RS02650	COG1175	transmembrane transport
SMALA_RS02655	COG0395	ABC-type sugar transport system, permease component
SMALA_RS02660	COG0366	Alpha amylase catalytic
SMALA_RS02670	COG0137	argininosuccinate synthase activity
SMALA_RS02680	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS02695	COG2353	YceI-like domain
SMALA_RS02710	COG0277	FAD linked oxidase domain protein
SMALA_RS02725	COG0577	efflux transmembrane transporter activity
SMALA_RS02725	COG1136	(ABC) transporter
SMALA_RS02730	COG0577	efflux transmembrane transporter activity
SMALA_RS02730	COG1136	(ABC) transporter
SMALA_RS02735	COG2197	response regulator
SMALA_RS02740	COG4585	Histidine kinase
SMALA_RS02760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS02765	COG0431	NADPH-dependent FMN reductase
SMALA_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS02880	COG1316	TRANSCRIPTIONal
SMALA_RS02885	COG2261	transglycosylase associated protein
SMALA_RS02895	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS02900	COG0477	Major facilitator Superfamily
SMALA_RS02905	COG1819	glycosyl
SMALA_RS02910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SMALA_RS02915	COG1309	transcriptional regulator
SMALA_RS02935	COG0583	DNA-binding transcription factor activity
SMALA_RS02950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMALA_RS02995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMALA_RS03005	COG0254	rRNA binding
SMALA_RS03010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMALA_RS03015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMALA_RS03020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMALA_RS03025	COG1024	Enoyl-CoA hydratase
SMALA_RS03075	COG1113	amino acid transport
SMALA_RS03080	COG2186	Transcriptional regulator
SMALA_RS03095	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMALA_RS03100	COG0673	inositol 2-dehydrogenase activity
SMALA_RS03115	COG2318	DinB family
SMALA_RS03120	COG2309	aminopeptidase activity
SMALA_RS03125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS03130	COG0477	Major facilitator Superfamily
SMALA_RS03155	COG1335	isochorismatase
SMALA_RS03160	COG0596	Alpha beta hydrolase
SMALA_RS03185	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS03195	COG2378	regulation of single-species biofilm formation
SMALA_RS03205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMALA_RS03250	COG0583	DNA-binding transcription factor activity
SMALA_RS03290	COG0384	phenazine biosynthesis protein PhzF
SMALA_RS03315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMALA_RS03315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMALA_RS03325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMALA_RS03365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMALA_RS03400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMALA_RS03420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS03430	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SMALA_RS03435	COG1177	transmembrane transport
SMALA_RS03440	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMALA_RS03445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SMALA_RS03450	COG3842	ATPase activity
SMALA_RS03465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMALA_RS03470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMALA_RS03485	COG2018	Roadblock/LC7 domain
SMALA_RS03500	COG2146	nitrite reductase [NAD(P)H] activity
SMALA_RS03525	COG4638	Rieske (2fe-2S)
SMALA_RS03530	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS03555	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SMALA_RS03575	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMALA_RS03580	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SMALA_RS03585	COG1984	allophanate hydrolase subunit 2
SMALA_RS03615	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS03710	COG2070	2-Nitropropane dioxygenase
SMALA_RS03720	COG0515	serine threonine protein kinase
SMALA_RS03720	COG2815	serine threonine protein kinase
SMALA_RS03745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMALA_RS03750	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS03760	COG2376	Dihydroxyacetone kinase
SMALA_RS03765	COG1461	Dihydroxyacetone kinase
SMALA_RS03770	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SMALA_RS03770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMALA_RS03770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMALA_RS03775	COG0142	geranyltranstransferase activity
SMALA_RS03785	COG2124	cytochrome p450
SMALA_RS03790	COG2124	cytochrome p450
SMALA_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS03820	COG0494	nUDIX hydrolase
SMALA_RS03835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMALA_RS03895	COG1349	DNA-binding transcription factor activity
SMALA_RS03930	COG1940	carbohydrate kinase activity
SMALA_RS03960	COG2197	response regulator
SMALA_RS03975	COG0445	tRNA wobble uridine modification
SMALA_RS03985	COG1660	Displays ATPase and GTPase activities
SMALA_RS03990	COG0395	ABC-type sugar transport system, permease component
SMALA_RS03995	COG1175	transmembrane transport
SMALA_RS04005	COG3345	alpha-galactosidase
SMALA_RS04055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMALA_RS04095	COG0584	glycerophosphoryl diester phosphodiesterase
SMALA_RS04130	COG1309	transcriptional regulator
SMALA_RS04205	COG0671	phosphoesterase, PA-phosphatase related
SMALA_RS04210	COG2271	Major facilitator Superfamily
SMALA_RS04215	COG1846	Transcriptional regulator
SMALA_RS04220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMALA_RS04225	COG1024	Enoyl-CoA hydratase
SMALA_RS04235	COG1024	Enoyl-CoA hydratase
SMALA_RS04240	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS04245	COG2070	2-Nitropropane dioxygenase
SMALA_RS04285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMALA_RS04290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS04295	COG0601	transmembrane transport
SMALA_RS04300	COG4166	transmembrane transport
SMALA_RS04320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMALA_RS04335	COG0596	Alpha beta hydrolase
SMALA_RS04340	COG3321	synthase
SMALA_RS04340	COG0604	alcohol dehydrogenase
SMALA_RS04350	COG0604	alcohol dehydrogenase
SMALA_RS04350	COG3321	synthase
SMALA_RS04380	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS04390	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS04430	COG1309	transcriptional regulator
SMALA_RS04450	COG2233	PERMEase
SMALA_RS04455	COG0640	Transcriptional regulator
SMALA_RS04460	COG1902	pentaerythritol trinitrate reductase activity
SMALA_RS04470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMALA_RS04490	COG2706	6-phosphogluconolactonase activity
SMALA_RS04510	COG2027	D-alanyl-D-alanine carboxypeptidase
SMALA_RS04520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS04525	COG1116	anion transmembrane transporter activity
SMALA_RS04575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS04580	COG3119	arylsulfatase activity
SMALA_RS04595	COG3639	organic phosphonate transmembrane transporter activity
SMALA_RS04605	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SMALA_RS04610	COG2326	polyphosphate kinase activity
SMALA_RS04635	COG3850	Histidine kinase
SMALA_RS04645	COG1131	(ABC) transporter
SMALA_RS04650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMALA_RS04660	COG2188	Transcriptional regulator
SMALA_RS04665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMALA_RS04670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMALA_RS04690	COG1940	carbohydrate kinase activity
SMALA_RS04710	COG1414	Transcriptional regulator
SMALA_RS04720	COG1175	transmembrane transport
SMALA_RS04725	COG0395	ABC-type sugar transport system, permease component
SMALA_RS04730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMALA_RS04750	COG2226	methyltransferase
SMALA_RS04765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMALA_RS04790	COG1902	pentaerythritol trinitrate reductase activity
SMALA_RS04805	COG0656	L-ascorbic acid biosynthetic process
SMALA_RS04815	COG2814	Major facilitator Superfamily
SMALA_RS04825	COG0583	DNA-binding transcription factor activity
SMALA_RS04840	COG1231	oxidoreductase activity
SMALA_RS04845	COG3961	Belongs to the TPP enzyme family
SMALA_RS04860	COG0251	oxidation-reduction process
SMALA_RS04875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS04885	COG0596	Alpha beta hydrolase
SMALA_RS04895	COG2267	carboxylic ester hydrolase activity
SMALA_RS04925	COG0243	molybdopterin cofactor binding
SMALA_RS04930	COG1120	ATPase activity
SMALA_RS04935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS04945	COG1595	DNA-templated transcription, initiation
SMALA_RS04950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMALA_RS04970	COG0515	serine threonine protein kinase
SMALA_RS04990	COG3971	2-oxopent-4-enoate hydratase activity
SMALA_RS05015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS05020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS05030	COG1116	anion transmembrane transporter activity
SMALA_RS05035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS05050	COG0745	RESPONSE REGULATOR receiver
SMALA_RS05055	COG2205	protein histidine kinase activity
SMALA_RS05065	COG1309	transcriptional regulator
SMALA_RS05080	COG1309	transcriptional regulator
SMALA_RS05090	COG0277	FAD linked oxidase domain protein
SMALA_RS05125	COG2197	response regulator
SMALA_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS05180	COG1802	Transcriptional regulator
SMALA_RS05185	COG1129	ABC transporter
SMALA_RS05200	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS05210	COG3469	chitinase activity
SMALA_RS05250	COG3469	chitinase activity
SMALA_RS05290	COG4209	transmembrane transport
SMALA_RS05295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMALA_RS05305	COG0673	inositol 2-dehydrogenase activity
SMALA_RS05365	COG0698	ribose 5-phosphate isomerase
SMALA_RS05370	COG2376	Dihydroxyacetone kinase
SMALA_RS05380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMALA_RS05385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMALA_RS05390	COG1349	DNA-binding transcription factor activity
SMALA_RS05395	COG2814	Major facilitator Superfamily
SMALA_RS05405	COG1349	DNA-binding transcription factor activity
SMALA_RS05410	COG1070	Carbohydrate kinase
SMALA_RS05415	COG1070	Carbohydrate kinase
SMALA_RS05420	COG0588	phosphoglycerate mutase activity
SMALA_RS05430	COG3795	YCII-related domain
SMALA_RS05435	COG4941	Belongs to the sigma-70 factor family
SMALA_RS05450	COG0300	oxidoreductase activity
SMALA_RS05550	COG0436	Aminotransferase
SMALA_RS05555	COG1802	Transcriptional regulator
SMALA_RS05560	COG1309	transcriptional regulator
SMALA_RS05565	COG0154	amidase activity
SMALA_RS05590	COG1968	undecaprenyl-diphosphatase activity
SMALA_RS05595	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS05615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMALA_RS05620	COG4977	sequence-specific DNA binding
SMALA_RS05625	COG0583	DNA-binding transcription factor activity
SMALA_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS05645	COG0583	DNA-binding transcription factor activity
SMALA_RS05670	COG2072	flavoprotein involved in K transport
SMALA_RS05680	COG0596	Alpha beta hydrolase
SMALA_RS05705	COG1233	COG1233 Phytoene dehydrogenase and related
SMALA_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS05765	COG3850	Histidine kinase
SMALA_RS05770	COG2197	response regulator
SMALA_RS05810	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS05815	COG0583	DNA-binding transcription factor activity
SMALA_RS05835	COG2824	Alkylphosphonate utilization operon protein PhnA
SMALA_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS05870	COG0583	DNA-binding transcription factor activity
SMALA_RS05875	COG1309	transcriptional regulator
SMALA_RS05885	COG0702	epimerase
SMALA_RS05905	COG0402	S-adenosylhomocysteine deaminase activity
SMALA_RS05925	COG2124	cytochrome p450
SMALA_RS05935	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS05950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMALA_RS05955	COG1937	Protein conserved in bacteria
SMALA_RS05960	COG0730	response to heat
SMALA_RS05995	COG0745	RESPONSE REGULATOR receiver
SMALA_RS06005	COG3180	Ammonia monooxygenase
SMALA_RS06010	COG0745	RESPONSE REGULATOR receiver
SMALA_RS06015	COG2205	protein histidine kinase activity
SMALA_RS06030	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS06040	COG1175	transmembrane transport
SMALA_RS06050	COG2188	Transcriptional regulator
SMALA_RS06060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMALA_RS06065	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS06075	COG1064	alcohol dehydrogenase
SMALA_RS06080	COG1309	transcriptional regulator
SMALA_RS06090	COG0300	oxidoreductase activity
SMALA_RS06100	COG3458	cephalosporin-C deacetylase activity
SMALA_RS06105	COG0346	lactoylglutathione lyase activity
SMALA_RS06125	COG0145	ligase activity
SMALA_RS06150	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS06175	COG2814	Major facilitator Superfamily
SMALA_RS06190	COG4585	Histidine kinase
SMALA_RS06195	COG2409	Drug exporters of the RND superfamily
SMALA_RS06200	COG1716	ATPase activity
SMALA_RS06200	COG0842	Transport permease protein
SMALA_RS06200	COG1131	(ABC) transporter
SMALA_RS06235	COG1120	ATPase activity
SMALA_RS06240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS06250	COG4221	oxidoreductase activity
SMALA_RS06260	COG0069	glutamate synthase activity
SMALA_RS06280	COG0640	Transcriptional regulator
SMALA_RS06285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMALA_RS06295	COG1316	TRANSCRIPTIONal
SMALA_RS06300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMALA_RS06315	COG0156	8-amino-7-oxononanoate synthase activity
SMALA_RS06325	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS06335	COG1396	sequence-specific DNA binding
SMALA_RS06345	COG2318	DinB family
SMALA_RS06355	COG1082	Xylose isomerase domain protein TIM barrel
SMALA_RS06360	COG0300	oxidoreductase activity
SMALA_RS06385	COG0477	Major facilitator Superfamily
SMALA_RS06410	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS06420	COG0477	Major facilitator Superfamily
SMALA_RS06435	COG0604	alcohol dehydrogenase
SMALA_RS06435	COG3321	synthase
SMALA_RS06440	COG3321	synthase
SMALA_RS06440	COG0604	alcohol dehydrogenase
SMALA_RS06445	COG0604	alcohol dehydrogenase
SMALA_RS06445	COG3321	synthase
SMALA_RS06455	COG2197	response regulator
SMALA_RS06465	COG0702	epimerase
SMALA_RS06470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS06500	COG1408	metallophosphoesterase
SMALA_RS06520	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SMALA_RS06545	COG4770	biotin carboxylase activity
SMALA_RS06550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMALA_RS06555	COG2807	transmembrane transport
SMALA_RS06570	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS06590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMALA_RS06615	COG1024	Enoyl-CoA hydratase
SMALA_RS06620	COG1024	Enoyl-CoA hydratase
SMALA_RS06625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMALA_RS06630	COG1022	Amp-dependent synthetase and ligase
SMALA_RS06660	COG1309	transcriptional regulator
SMALA_RS06665	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS06670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS06680	COG0667	Aldo Keto reductase
SMALA_RS06685	COG0583	DNA-binding transcription factor activity
SMALA_RS06695	COG1620	l-lactate permease
SMALA_RS06700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS06700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS06715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS06720	COG2186	Transcriptional regulator
SMALA_RS06730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS06770	COG0583	DNA-binding transcription factor activity
SMALA_RS06800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMALA_RS06815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMALA_RS06830	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS06840	COG0546	phosphoglycolate phosphatase activity
SMALA_RS06855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMALA_RS06870	COG0604	alcohol dehydrogenase
SMALA_RS06870	COG3321	synthase
SMALA_RS06890	COG0604	alcohol dehydrogenase
SMALA_RS06890	COG3321	synthase
SMALA_RS06890	COG0604	alcohol dehydrogenase
SMALA_RS06890	COG3321	synthase
SMALA_RS06905	COG0604	alcohol dehydrogenase
SMALA_RS06915	COG0531	amino acid
SMALA_RS06980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SMALA_RS06990	COG0277	FAD linked oxidase domain protein
SMALA_RS07000	COG0028	Belongs to the TPP enzyme family
SMALA_RS07015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMALA_RS07030	COG1472	Belongs to the glycosyl hydrolase 3 family
SMALA_RS07110	COG3959	Transketolase, thiamine diphosphate binding domain
SMALA_RS07115	COG3958	Transketolase
SMALA_RS07120	COG2267	carboxylic ester hydrolase activity
SMALA_RS07125	COG1228	amidohydrolase
SMALA_RS07140	COG1309	transcriptional regulator
SMALA_RS07160	COG4175	Glycine betaine
SMALA_RS07160	COG0517	IMP dehydrogenase activity
SMALA_RS07165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMALA_RS07190	COG0805	protein transport
SMALA_RS07195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMALA_RS07215	COG2378	regulation of single-species biofilm formation
SMALA_RS07225	COG0545	Peptidyl-prolyl cis-trans isomerase
SMALA_RS07230	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMALA_RS07240	COG1609	Transcriptional regulator
SMALA_RS07245	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMALA_RS07250	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMALA_RS07260	COG4122	O-methyltransferase activity
SMALA_RS07265	COG1222	aaa ATPase
SMALA_RS07285	COG0517	IMP dehydrogenase activity
SMALA_RS07285	COG1994	Peptidase M50
SMALA_RS07295	COG2197	response regulator
SMALA_RS07305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMALA_RS07310	COG1410	methionine synthase
SMALA_RS07310	COG0646	methionine synthase
SMALA_RS07315	COG1414	Transcriptional regulator
SMALA_RS07320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMALA_RS07325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMALA_RS07330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMALA_RS07345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS07355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS07365	COG2186	Transcriptional regulator
SMALA_RS07380	COG4211	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS07385	COG1129	ABC transporter
SMALA_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS07400	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS07410	COG0215	cysteine-tRNA ligase activity
SMALA_RS07430	COG0598	Magnesium transport protein CorA
SMALA_RS07440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS07445	COG0667	Aldo Keto reductase
SMALA_RS07550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMALA_RS07585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMALA_RS07765	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS07780	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMALA_RS07800	COG0789	Transcriptional regulator
SMALA_RS07810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMALA_RS07875	COG1074	ATP-dependent DNA helicase activity
SMALA_RS07905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMALA_RS07910	COG0515	serine threonine protein kinase
SMALA_RS07910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMALA_RS07935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMALA_RS07940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMALA_RS07945	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMALA_RS07965	COG4221	oxidoreductase activity
SMALA_RS07985	COG0297	glycogen (starch) synthase activity
SMALA_RS08005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMALA_RS08010	COG2080	2 iron, 2 sulfur cluster binding
SMALA_RS08015	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMALA_RS08020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS08040	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS08095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMALA_RS08100	COG2149	membrane
SMALA_RS08115	COG1733	regulation of RNA biosynthetic process
SMALA_RS08135	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS08180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMALA_RS08185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMALA_RS08190	COG0142	geranyltranstransferase activity
SMALA_RS08195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMALA_RS08200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMALA_RS08215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS08230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMALA_RS08235	COG2409	Drug exporters of the RND superfamily
SMALA_RS08260	COG2851	Citrate transporter
SMALA_RS08265	COG0243	molybdopterin cofactor binding
SMALA_RS08270	COG1309	transcriptional regulator
SMALA_RS08275	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMALA_RS08280	COG2188	Transcriptional regulator
SMALA_RS08310	COG0515	serine threonine protein kinase
SMALA_RS08315	COG2755	lipolytic protein G-D-S-L family
SMALA_RS08330	COG0463	Glycosyl transferase, family 2
SMALA_RS08345	COG0726	polysaccharide deacetylase
SMALA_RS08345	COG1649	PFAM Uncharacterised BCR, COG1649
SMALA_RS08365	COG1834	amidinotransferase
SMALA_RS08385	COG2226	methyltransferase
SMALA_RS08395	COG0596	Alpha beta hydrolase
SMALA_RS08395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMALA_RS08395	COG2226	methyltransferase
SMALA_RS08400	COG2124	cytochrome p450
SMALA_RS08425	COG0519	Catalyzes the synthesis of GMP from XMP
SMALA_RS08425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMALA_RS08450	COG0019	diaminopimelate decarboxylase activity
SMALA_RS08480	COG1846	Transcriptional regulator
SMALA_RS08485	COG1764	response to oxidative stress
SMALA_RS08495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMALA_RS08500	COG0587	DNA-directed DNA polymerase activity
SMALA_RS08505	COG3467	pyridoxamine 5'-phosphate
SMALA_RS08520	COG0330	HflC and HflK could
SMALA_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMALA_RS08535	COG1126	abc transporter atp-binding protein
SMALA_RS08555	COG1799	cell septum assembly
SMALA_RS08560	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS08575	COG0671	phosphoesterase, PA-phosphatase related
SMALA_RS08625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMALA_RS08640	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS08655	COG1160	GTP binding
SMALA_RS08665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMALA_RS08680	COG1187	pseudouridine synthase activity
SMALA_RS08685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMALA_RS08690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMALA_RS08705	COG0686	Belongs to the AlaDH PNT family
SMALA_RS08710	COG3903	Transcriptional regulator
SMALA_RS08710	COG3629	intracellular signal transduction
SMALA_RS08715	COG0494	nUDIX hydrolase
SMALA_RS08720	COG0504	CTP synthase activity
SMALA_RS08725	COG3387	PFAM Glycoside hydrolase 15-related
SMALA_RS08740	COG0297	glycogen (starch) synthase activity
SMALA_RS08745	COG0497	DNA recombination
SMALA_RS08750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMALA_RS08770	COG1120	ATPase activity
SMALA_RS08775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS08780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS08785	COG0647	UMP catabolic process
SMALA_RS08825	COG2094	Belongs to the DNA glycosylase MPG family
SMALA_RS08840	COG1881	PFAM PEBP family protein
SMALA_RS08860	COG1119	ATPase activity
SMALA_RS08875	COG2197	response regulator
SMALA_RS08880	COG4585	Histidine kinase
SMALA_RS08885	COG5280	Phage tail tape measure protein TP901
SMALA_RS08885	COG3953	SLT domain
SMALA_RS08890	COG1716	ATPase activity
SMALA_RS08890	COG1131	(ABC) transporter
SMALA_RS08890	COG0842	Transport permease protein
SMALA_RS08900	COG0560	Phosphoserine phosphatase
SMALA_RS08900	COG3830	Belongs to the UPF0237 family
SMALA_RS08915	COG2807	transmembrane transport
SMALA_RS08920	COG2186	Transcriptional regulator
SMALA_RS08930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMALA_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS08940	COG1902	pentaerythritol trinitrate reductase activity
SMALA_RS09005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMALA_RS09025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMALA_RS09030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMALA_RS09065	COG2176	DNA-directed DNA polymerase activity
SMALA_RS09080	COG3387	PFAM Glycoside hydrolase 15-related
SMALA_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS09125	COG4999	Histidine kinase
SMALA_RS09125	COG3850	Histidine kinase
SMALA_RS09125	COG3437	response regulator, receiver
SMALA_RS09125	COG2205	protein histidine kinase activity
SMALA_RS09145	COG0488	(ABC) transporter
SMALA_RS09160	COG0235	Class ii aldolase
SMALA_RS09175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMALA_RS09180	COG1492	cobalamin metabolic process
SMALA_RS09195	COG1797	cobyrinic acid a,c-diamide synthase activity
SMALA_RS09240	COG0456	acetyltransferase
SMALA_RS09250	COG1917	Cupin 2, conserved barrel domain protein
SMALA_RS09255	COG5285	phytanoyl-CoA dioxygenase
SMALA_RS09260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMALA_RS09270	COG1414	Transcriptional regulator
SMALA_RS09280	COG4585	Histidine kinase
SMALA_RS09290	COG0667	Aldo Keto reductase
SMALA_RS09295	COG2252	PERMEase
SMALA_RS09325	COG0395	ABC-type sugar transport system, permease component
SMALA_RS09340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMALA_RS09345	COG1802	Transcriptional regulator
SMALA_RS09365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMALA_RS09370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMALA_RS09375	COG1335	isochorismatase
SMALA_RS09380	COG0477	Major facilitator Superfamily
SMALA_RS09400	COG1090	epimerase
SMALA_RS09435	COG2171	N-acyltransferase activity
SMALA_RS09440	COG3226	Transcriptional regulator
SMALA_RS09445	COG2076	Multidrug Resistance protein
SMALA_RS09450	COG2151	metal-sulfur cluster biosynthetic enzyme
SMALA_RS09455	COG0822	iron-sulfur transferase activity
SMALA_RS09460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMALA_RS09465	COG0396	ATPase activity
SMALA_RS09475	COG0719	Fe-S assembly protein
SMALA_RS09500	COG1612	heme a metabolic process
SMALA_RS09520	COG0109	protoheme IX farnesyltransferase activity
SMALA_RS09525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMALA_RS09530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMALA_RS09545	COG0363	glucosamine-6-phosphate deaminase activity
SMALA_RS09550	COG0166	Belongs to the GPI family
SMALA_RS09565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMALA_RS09570	COG0149	triose-phosphate isomerase activity
SMALA_RS09575	COG0126	phosphoglycerate kinase activity
SMALA_RS09580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMALA_RS09590	COG1481	regulation of sporulation
SMALA_RS09595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMALA_RS09600	COG1660	Displays ATPase and GTPase activities
SMALA_RS09605	COG0322	excinuclease ABC activity
SMALA_RS09615	COG1609	Transcriptional regulator
SMALA_RS09625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMALA_RS09640	COG0477	Major facilitator Superfamily
SMALA_RS09660	COG0556	nucleotide-excision repair
SMALA_RS09665	COG0584	glycerophosphoryl diester phosphodiesterase
SMALA_RS09670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMALA_RS09720	COG0237	dephospho-CoA kinase activity
SMALA_RS09735	COG0539	negative regulation of cytoplasmic translation
SMALA_RS09745	COG2226	methyltransferase
SMALA_RS09750	COG1643	Atp-dependent helicase
SMALA_RS09795	COG2050	protein possibly involved in aromatic compounds catabolism
SMALA_RS09820	COG0411	ABC transporter
SMALA_RS09855	COG0494	nUDIX hydrolase
SMALA_RS09860	COG0737	Belongs to the 5'-nucleotidase family
SMALA_RS09885	COG0287	Prephenate dehydrogenase
SMALA_RS09885	COG1605	Chorismate mutase
SMALA_RS09905	COG3467	pyridoxamine 5'-phosphate
SMALA_RS09920	COG1131	(ABC) transporter
SMALA_RS09925	COG1725	Transcriptional regulator
SMALA_RS09935	COG0070	glutamate synthase
SMALA_RS09935	COG0069	glutamate synthase activity
SMALA_RS09935	COG0067	glutamate synthase
SMALA_RS09945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMALA_RS09955	COG0159	tryptophan synthase activity
SMALA_RS09960	COG0133	tryptophan synthase activity
SMALA_RS09965	COG0134	indole-3-glycerol-phosphate synthase activity
SMALA_RS09985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMALA_RS09990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMALA_RS10025	COG1120	ATPase activity
SMALA_RS10040	COG4221	oxidoreductase activity
SMALA_RS10045	COG0107	imidazoleglycerol-phosphate synthase activity
SMALA_RS10050	COG0251	oxidation-reduction process
SMALA_RS10055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMALA_RS10060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMALA_RS10065	COG0131	Imidazoleglycerol-phosphate dehydratase
SMALA_RS10070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMALA_RS10075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMALA_RS10085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMALA_RS10090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMALA_RS10110	COG1432	Conserved Protein
SMALA_RS10120	COG0587	DNA-directed DNA polymerase activity
SMALA_RS10165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMALA_RS10175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMALA_RS10190	COG1799	cell septum assembly
SMALA_RS10200	COG1496	oxidoreductase activity
SMALA_RS10205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMALA_RS10210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SMALA_RS10215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMALA_RS10225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMALA_RS10230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMALA_RS10240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMALA_RS10255	COG0275	rRNA processing
SMALA_RS10265	COG0714	Associated with various cellular activities
SMALA_RS10295	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMALA_RS10305	COG1309	transcriptional regulator
SMALA_RS10310	COG1233	COG1233 Phytoene dehydrogenase and related
SMALA_RS10325	COG0352	thiamine-phosphate diphosphorylase activity
SMALA_RS10340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMALA_RS10340	COG2022	thiamine diphosphate biosynthetic process
SMALA_RS10350	COG2022	thiamine diphosphate biosynthetic process
SMALA_RS10360	COG2815	serine threonine protein kinase
SMALA_RS10360	COG0515	serine threonine protein kinase
SMALA_RS10370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMALA_RS10380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMALA_RS10385	COG2193	ferroxidase activity
SMALA_RS10390	COG0243	molybdopterin cofactor binding
SMALA_RS10395	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMALA_RS10405	COG0205	6-phosphofructokinase activity
SMALA_RS10440	COG1940	carbohydrate kinase activity
SMALA_RS10450	COG0003	Pfam Anion-transporting ATPase
SMALA_RS10510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMALA_RS10515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMALA_RS10520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMALA_RS10525	COG0723	plastoquinol--plastocyanin reductase activity
SMALA_RS10530	COG2010	Cytochrome c
SMALA_RS10535	COG1845	cytochrome c oxidase, subunit III
SMALA_RS10545	COG1376	ErfK ybiS ycfS ynhG family protein
SMALA_RS10555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMALA_RS10560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMALA_RS10575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS10595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SMALA_RS10600	COG2197	response regulator
SMALA_RS10605	COG4585	Histidine kinase
SMALA_RS10640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMALA_RS10645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMALA_RS10650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMALA_RS10655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMALA_RS10660	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMALA_RS10670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMALA_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS10705	COG0640	Transcriptional regulator
SMALA_RS10715	COG0321	lipoyl(octanoyl) transferase activity
SMALA_RS10720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMALA_RS10740	COG0174	glutamine synthetase
SMALA_RS10760	COG1280	lysine exporter protein (LysE YggA)
SMALA_RS10770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMALA_RS10800	COG0477	Major facilitator Superfamily
SMALA_RS10815	COG0745	RESPONSE REGULATOR receiver
SMALA_RS10835	COG2197	response regulator
SMALA_RS10865	COG3833	ABC-type maltose transport systems, permease component
SMALA_RS10875	COG2182	Extracellular solute-binding protein
SMALA_RS10880	COG0366	Alpha amylase catalytic
SMALA_RS10885	COG1609	Transcriptional regulator
SMALA_RS10895	COG0561	phosphatase activity
SMALA_RS10900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMALA_RS10910	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SMALA_RS10935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMALA_RS10940	COG0174	glutamine synthetase
SMALA_RS10945	COG2132	Multicopper oxidase
SMALA_RS10950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMALA_RS10950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMALA_RS10955	COG2267	carboxylic ester hydrolase activity
SMALA_RS10960	COG2814	Major facilitator Superfamily
SMALA_RS10970	COG1309	transcriptional regulator
SMALA_RS10975	COG0477	Major facilitator Superfamily
SMALA_RS10980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMALA_RS11005	COG1994	Peptidase M50
SMALA_RS11020	COG0395	ABC-type sugar transport system, permease component
SMALA_RS11025	COG1175	transmembrane transport
SMALA_RS11050	COG0181	hydroxymethylbilane synthase activity
SMALA_RS11055	COG0113	porphobilinogen synthase activity
SMALA_RS11105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMALA_RS11110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS11115	COG1120	ATPase activity
SMALA_RS11120	COG2822	iron ion transport
SMALA_RS11125	COG2837	iron assimilation
SMALA_RS11130	COG0672	)-iron permease
SMALA_RS11155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMALA_RS11165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMALA_RS11170	COG2814	Major facilitator Superfamily
SMALA_RS11180	COG3540	Alkaline phosphatase
SMALA_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS11220	COG0443	Heat shock 70 kDa protein
SMALA_RS11225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMALA_RS11240	COG0542	response to heat
SMALA_RS11270	COG0596	Alpha beta hydrolase
SMALA_RS11275	COG0583	DNA-binding transcription factor activity
SMALA_RS11280	COG0473	3-isopropylmalate dehydrogenase activity
SMALA_RS11300	COG2197	response regulator
SMALA_RS11310	COG2409	Drug exporters of the RND superfamily
SMALA_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS11335	COG3022	response to hydroperoxide
SMALA_RS11340	COG0800	Aldolase
SMALA_RS11355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMALA_RS11360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMALA_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS11380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SMALA_RS11385	COG2030	dehydratase
SMALA_RS11390	COG3510	cephalosporin hydroxylase
SMALA_RS11395	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMALA_RS11405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS11425	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS11430	COG1309	transcriptional regulator
SMALA_RS11435	COG2197	response regulator
SMALA_RS11480	COG3845	ABC transporter
SMALA_RS11495	COG0183	Belongs to the thiolase family
SMALA_RS11500	COG2124	cytochrome p450
SMALA_RS11520	COG2207	Transcriptional regulator
SMALA_RS11535	COG0604	alcohol dehydrogenase
SMALA_RS11570	COG0604	alcohol dehydrogenase
SMALA_RS11575	COG2207	Transcriptional regulator
SMALA_RS11600	COG5002	protein histidine kinase activity
SMALA_RS11620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMALA_RS11650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMALA_RS11700	COG3344	reverse transcriptase
SMALA_RS11725	COG1396	sequence-specific DNA binding
SMALA_RS11730	COG0740	serine-type endopeptidase activity
SMALA_RS11735	COG0740	serine-type endopeptidase activity
SMALA_RS11755	COG1309	transcriptional regulator
SMALA_RS11775	COG3903	Transcriptional regulator
SMALA_RS11775	COG3629	intracellular signal transduction
SMALA_RS11780	COG4106	trans-aconitate 2-methyltransferase activity
SMALA_RS11795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMALA_RS11850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMALA_RS11860	COG3321	synthase
SMALA_RS11860	COG0604	alcohol dehydrogenase
SMALA_RS11895	COG1358	cellular component organization or biogenesis
SMALA_RS11945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SMALA_RS11955	COG0477	Major facilitator Superfamily
SMALA_RS11960	COG1309	transcriptional regulator
SMALA_RS11975	COG4585	Histidine kinase
SMALA_RS11980	COG2197	response regulator
SMALA_RS12000	COG0667	Aldo Keto reductase
SMALA_RS12005	COG0789	Transcriptional regulator
SMALA_RS12030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMALA_RS12035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS12040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS12085	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS12105	COG1129	ABC transporter
SMALA_RS12110	COG4214	carbohydrate transport
SMALA_RS12145	COG2130	NADP-dependent
SMALA_RS12160	COG3386	PFAM SMP-30 Gluconolaconase
SMALA_RS12165	COG1414	Transcriptional regulator
SMALA_RS12180	COG0588	phosphoglycerate mutase activity
SMALA_RS12185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMALA_RS12220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS12225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMALA_RS12230	COG2080	2 iron, 2 sulfur cluster binding
SMALA_RS12235	COG2207	Transcriptional regulator
SMALA_RS12245	COG1486	melibiose metabolic process
SMALA_RS12265	COG1175	transmembrane transport
SMALA_RS12270	COG0395	ABC-type sugar transport system, permease component
SMALA_RS12275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMALA_RS12285	COG2197	response regulator
SMALA_RS12290	COG3851	Histidine kinase
SMALA_RS12350	COG1070	Carbohydrate kinase
SMALA_RS12360	COG0358	DNA primase activity
SMALA_RS12370	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMALA_RS12380	COG0243	molybdopterin cofactor binding
SMALA_RS12385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMALA_RS12420	COG0745	RESPONSE REGULATOR receiver
SMALA_RS12450	COG2124	cytochrome p450
SMALA_RS12455	COG2124	cytochrome p450
SMALA_RS12460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMALA_RS12465	COG2146	nitrite reductase [NAD(P)H] activity
SMALA_RS12465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMALA_RS12475	COG1609	Transcriptional regulator
SMALA_RS12485	COG1175	transmembrane transport
SMALA_RS12495	COG1472	Belongs to the glycosyl hydrolase 3 family
SMALA_RS12505	COG0300	oxidoreductase activity
SMALA_RS12510	COG2890	protein-(glutamine-N5) methyltransferase activity
SMALA_RS12515	COG1846	Transcriptional regulator
SMALA_RS12520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SMALA_RS12530	COG0183	Belongs to the thiolase family
SMALA_RS12535	COG3485	protocatechuate 3,4-dioxygenase
SMALA_RS12545	COG3485	protocatechuate 3,4-dioxygenase
SMALA_RS12550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMALA_RS12555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMALA_RS12560	COG2182	Extracellular solute-binding protein
SMALA_RS12565	COG1175	transmembrane transport
SMALA_RS12570	COG0395	ABC-type sugar transport system, permease component
SMALA_RS12575	COG2188	Transcriptional regulator
SMALA_RS12580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMALA_RS12585	COG0531	amino acid
SMALA_RS12595	COG2205	protein histidine kinase activity
SMALA_RS12600	COG0745	RESPONSE REGULATOR receiver
SMALA_RS12630	COG0574	Belongs to the PEP-utilizing enzyme family
SMALA_RS12630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMALA_RS12635	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SMALA_RS12675	COG0477	Major facilitator Superfamily
SMALA_RS12680	COG2197	response regulator
SMALA_RS12700	COG0423	glycine-tRNA ligase activity
SMALA_RS12710	COG1121	(ABC) transporter
SMALA_RS12715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMALA_RS12750	COG0596	Alpha beta hydrolase
SMALA_RS12770	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS12780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMALA_RS12785	COG1381	Involved in DNA repair and RecF pathway recombination
SMALA_RS12805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMALA_RS12850	COG3422	double-strand break repair
SMALA_RS12855	COG2197	response regulator
SMALA_RS12860	COG4585	Histidine kinase
SMALA_RS12865	COG2409	Drug exporters of the RND superfamily
SMALA_RS12875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMALA_RS12890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMALA_RS12910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMALA_RS12920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS12925	COG1234	tRNA 3'-trailer cleavage
SMALA_RS12930	COG0537	adenosine 5'-monophosphoramidase activity
SMALA_RS12950	COG0484	heat shock protein binding
SMALA_RS12955	COG1420	regulation of RNA biosynthetic process
SMALA_RS12980	COG1022	Amp-dependent synthetase and ligase
SMALA_RS12985	COG0481	GTPase activity
SMALA_RS12990	COG0268	Binds directly to 16S ribosomal RNA
SMALA_RS13020	COG1555	photosystem II stabilization
SMALA_RS13025	COG1307	EDD domain protein, DegV family
SMALA_RS13035	COG0495	leucyl-tRNA aminoacylation
SMALA_RS13060	COG0406	alpha-ribazole phosphatase activity
SMALA_RS13065	COG0799	negative regulation of ribosome biogenesis
SMALA_RS13075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMALA_RS13085	COG0501	Belongs to the peptidase M48B family
SMALA_RS13100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMALA_RS13110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMALA_RS13120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMALA_RS13125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMALA_RS13130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMALA_RS13135	COG1530	ribonuclease E activity
SMALA_RS13155	COG0772	Belongs to the SEDS family
SMALA_RS13160	COG0768	penicillin binding
SMALA_RS13175	COG1077	Cell shape determining protein MreB Mrl
SMALA_RS13180	COG0105	UTP biosynthetic process
SMALA_RS13190	COG0285	dihydrofolate synthase activity
SMALA_RS13195	COG0768	penicillin binding
SMALA_RS13200	COG0525	valine-tRNA ligase activity
SMALA_RS13220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMALA_RS13225	COG0740	serine-type endopeptidase activity
SMALA_RS13230	COG0740	serine-type endopeptidase activity
SMALA_RS13235	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMALA_RS13255	COG3594	Acyltransferase
SMALA_RS13275	COG4552	Acetyltransferase involved in intracellular survival and related
SMALA_RS13285	COG0698	ribose 5-phosphate isomerase
SMALA_RS13290	COG1113	amino acid transport
SMALA_RS13320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMALA_RS13335	COG1113	amino acid transport
SMALA_RS13345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMALA_RS13405	COG3291	Pkd domain containing protein
SMALA_RS13405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMALA_RS13415	COG0668	transmembrane transport
SMALA_RS13425	COG1846	Transcriptional regulator
SMALA_RS13425	COG1940	carbohydrate kinase activity
SMALA_RS13430	COG1653	transport
SMALA_RS13435	COG1175	transmembrane transport
SMALA_RS13440	COG0395	ABC-type sugar transport system, permease component
SMALA_RS13445	COG1486	melibiose metabolic process
SMALA_RS13460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMALA_RS13490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMALA_RS13525	COG0629	single-stranded DNA binding
SMALA_RS13555	COG1309	transcriptional regulator
SMALA_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS13590	COG0346	lactoylglutathione lyase activity
SMALA_RS13600	COG3251	PFAM MbtH domain protein
SMALA_RS13605	COG0142	geranyltranstransferase activity
SMALA_RS13610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMALA_RS13615	COG1993	acr, cog1993
SMALA_RS13620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMALA_RS13625	COG0583	DNA-binding transcription factor activity
SMALA_RS13645	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS13655	COG1131	(ABC) transporter
SMALA_RS13680	COG1309	transcriptional regulator
SMALA_RS13685	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS13690	COG1215	transferase activity, transferring glycosyl groups
SMALA_RS13760	COG0604	alcohol dehydrogenase
SMALA_RS13760	COG3321	synthase
SMALA_RS13765	COG3321	synthase
SMALA_RS13765	COG0604	alcohol dehydrogenase
SMALA_RS13775	COG3321	synthase
SMALA_RS13775	COG0604	alcohol dehydrogenase
SMALA_RS13795	COG0604	alcohol dehydrogenase
SMALA_RS13795	COG3321	synthase
SMALA_RS13810	COG3402	PFAM membrane-flanked domain
SMALA_RS13820	COG4585	Histidine kinase
SMALA_RS13825	COG2197	response regulator
SMALA_RS13865	COG3962	Belongs to the TPP enzyme family
SMALA_RS13870	COG3718	enzyme involved in inositol metabolism
SMALA_RS13880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS13905	COG0673	inositol 2-dehydrogenase activity
SMALA_RS13915	COG2409	Drug exporters of the RND superfamily
SMALA_RS13940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMALA_RS13945	COG1609	Transcriptional regulator
SMALA_RS13950	COG1129	ABC transporter
SMALA_RS13955	COG1879	ABC-type sugar transport system periplasmic component
SMALA_RS13960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS13965	COG1869	D-ribose catabolic process
SMALA_RS13975	COG0583	DNA-binding transcription factor activity
SMALA_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS13995	COG0673	inositol 2-dehydrogenase activity
SMALA_RS14015	COG0395	ABC-type sugar transport system, permease component
SMALA_RS14020	COG1175	transmembrane transport
SMALA_RS14045	COG1609	Transcriptional regulator
SMALA_RS14060	COG0454	-acetyltransferase
SMALA_RS14060	COG0456	acetyltransferase
SMALA_RS14095	COG1472	Belongs to the glycosyl hydrolase 3 family
SMALA_RS14120	COG2197	response regulator
SMALA_RS14125	COG4585	Histidine kinase
SMALA_RS14145	COG0640	Transcriptional regulator
SMALA_RS14160	COG1278	Cold shock
SMALA_RS14165	COG0513	Belongs to the DEAD box helicase family
SMALA_RS14175	COG1946	Acyl-CoA thioesterase
SMALA_RS14190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMALA_RS14210	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS14230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMALA_RS14235	COG0589	response to stress
SMALA_RS14245	COG4977	sequence-specific DNA binding
SMALA_RS14250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMALA_RS14320	COG3344	reverse transcriptase
SMALA_RS14360	COG1309	transcriptional regulator
SMALA_RS14365	COG0789	Transcriptional regulator
SMALA_RS14385	COG4733	cellulase activity
SMALA_RS14385	COG5297	Belongs to the glycosyl hydrolase family 6
SMALA_RS14395	COG5297	Belongs to the glycosyl hydrolase family 6
SMALA_RS14425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMALA_RS14430	COG3979	chitinase
SMALA_RS14515	COG4977	sequence-specific DNA binding
SMALA_RS14540	COG4585	Histidine kinase
SMALA_RS14545	COG2197	response regulator
SMALA_RS14560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS14580	COG3473	Maleate cis-trans isomerase
SMALA_RS14595	COG0154	amidase activity
SMALA_RS14605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMALA_RS14610	COG0765	amino acid transport
SMALA_RS14615	COG0765	amino acid transport
SMALA_RS14620	COG1126	abc transporter atp-binding protein
SMALA_RS14640	COG2267	carboxylic ester hydrolase activity
SMALA_RS14655	COG4770	biotin carboxylase activity
SMALA_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS14675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMALA_RS14685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS14690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMALA_RS14695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS14715	COG0300	oxidoreductase activity
SMALA_RS14725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS14740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS14745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS14750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS14760	COG0477	Major facilitator Superfamily
SMALA_RS14765	COG1063	alcohol dehydrogenase
SMALA_RS14780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMALA_RS14785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS14820	COG3397	chitin binding
SMALA_RS14850	COG2186	Transcriptional regulator
SMALA_RS14865	COG2197	response regulator
SMALA_RS14870	COG4585	Histidine kinase
SMALA_RS14915	COG0673	inositol 2-dehydrogenase activity
SMALA_RS14920	COG4702	Belongs to the UPF0303 family
SMALA_RS14940	COG3764	Sortase (surface protein transpeptidase)
SMALA_RS14945	COG2733	membrane
SMALA_RS14975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMALA_RS14980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMALA_RS15000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMALA_RS15010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMALA_RS15015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMALA_RS15020	COG1263	PTS System
SMALA_RS15025	COG2274	protein secretion by the type I secretion system
SMALA_RS15035	COG1234	tRNA 3'-trailer cleavage
SMALA_RS15055	COG1113	amino acid transport
SMALA_RS15065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMALA_RS15075	COG1335	isochorismatase
SMALA_RS15110	COG1064	alcohol dehydrogenase
SMALA_RS15115	COG0277	FAD linked oxidase domain protein
SMALA_RS15125	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SMALA_RS15165	COG3654	unkown
SMALA_RS15180	COG2855	membrane
SMALA_RS15190	COG0583	DNA-binding transcription factor activity
SMALA_RS15285	COG0546	phosphoglycolate phosphatase activity
SMALA_RS15290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS15305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS15320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMALA_RS15325	COG0395	ABC-type sugar transport system, permease component
SMALA_RS15330	COG1175	transmembrane transport
SMALA_RS15350	COG1678	Uncharacterized ACR, COG1678
SMALA_RS15355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMALA_RS15360	COG0776	regulation of translation
SMALA_RS15375	COG1278	Cold shock
SMALA_RS15380	COG3973	AAA domain
SMALA_RS15405	COG2223	nitrite transmembrane transporter activity
SMALA_RS15420	COG0583	DNA-binding transcription factor activity
SMALA_RS15430	COG0583	DNA-binding transcription factor activity
SMALA_RS15445	COG0395	ABC-type sugar transport system, permease component
SMALA_RS15450	COG1501	Belongs to the glycosyl hydrolase 31 family
SMALA_RS15455	COG2027	D-alanyl-D-alanine carboxypeptidase
SMALA_RS15470	COG0604	alcohol dehydrogenase
SMALA_RS15505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMALA_RS15510	COG0793	Belongs to the peptidase S41A family
SMALA_RS15520	COG2884	Cell division ATP-binding protein ftsE
SMALA_RS15535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMALA_RS15540	COG0515	serine threonine protein kinase
SMALA_RS15550	COG0515	serine threonine protein kinase
SMALA_RS15565	COG1653	transport
SMALA_RS15570	COG1175	transmembrane transport
SMALA_RS15575	COG0395	ABC-type sugar transport system, permease component
SMALA_RS15585	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS15615	COG0463	Glycosyl transferase, family 2
SMALA_RS15615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SMALA_RS15620	COG2902	Dehydrogenase
SMALA_RS15625	COG0693	protein deglycase activity
SMALA_RS15645	COG0653	protein targeting
SMALA_RS15655	COG3214	Protein conserved in bacteria
SMALA_RS15660	COG2197	response regulator
SMALA_RS15665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMALA_RS15675	COG0823	Involved in the tonB-independent uptake of proteins
SMALA_RS15680	COG5002	protein histidine kinase activity
SMALA_RS15685	COG0745	RESPONSE REGULATOR receiver
SMALA_RS15695	COG2188	Transcriptional regulator
SMALA_RS15775	COG0582	viral genome integration into host DNA
SMALA_RS15780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMALA_RS15815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMALA_RS15820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMALA_RS15820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMALA_RS15820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMALA_RS15830	COG1482	cell wall glycoprotein biosynthetic process
SMALA_RS15840	COG2835	tetraacyldisaccharide 4'-kinase activity
SMALA_RS15845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMALA_RS15850	COG1620	l-lactate permease
SMALA_RS15885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SMALA_RS15890	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SMALA_RS15890	COG0778	Nitroreductase
SMALA_RS15915	COG1316	TRANSCRIPTIONal
SMALA_RS15920	COG1316	TRANSCRIPTIONal
SMALA_RS15935	COG1316	TRANSCRIPTIONal
SMALA_RS15940	COG1607	acyl-coa hydrolase
SMALA_RS15945	COG1316	TRANSCRIPTIONal
SMALA_RS15955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SMALA_RS15980	COG2205	protein histidine kinase activity
SMALA_RS15985	COG0745	RESPONSE REGULATOR receiver
SMALA_RS15990	COG3104	oligopeptide transport
SMALA_RS16020	COG1366	Belongs to the anti-sigma-factor antagonist family
SMALA_RS16025	COG1191	sigma factor activity
SMALA_RS16030	COG1228	amidohydrolase
SMALA_RS16040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMALA_RS16045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMALA_RS16050	COG0604	alcohol dehydrogenase
SMALA_RS16065	COG0019	diaminopimelate decarboxylase activity
SMALA_RS16080	COG2986	histidine ammonia-lyase
SMALA_RS16090	COG1174	glycine betaine transport
SMALA_RS16105	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SMALA_RS16110	COG3903	Transcriptional regulator
SMALA_RS16110	COG3629	intracellular signal transduction
SMALA_RS16125	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS16140	COG2755	lipolytic protein G-D-S-L family
SMALA_RS16145	COG0183	Belongs to the thiolase family
SMALA_RS16175	COG1136	(ABC) transporter
SMALA_RS16180	COG0577	efflux transmembrane transporter activity
SMALA_RS16185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMALA_RS16190	COG1252	NADH dehydrogenase
SMALA_RS16210	COG0148	phosphopyruvate hydratase activity
SMALA_RS16220	COG1652	LysM domain
SMALA_RS16225	COG2124	cytochrome p450
SMALA_RS16260	COG3033	Beta-eliminating lyase
SMALA_RS16310	COG2986	histidine ammonia-lyase
SMALA_RS16320	COG1024	Enoyl-CoA hydratase
SMALA_RS16330	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMALA_RS16340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMALA_RS16350	COG0424	maF-like protein
SMALA_RS16360	COG4770	biotin carboxylase activity
SMALA_RS16395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMALA_RS16410	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS16415	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS16420	COG2159	amidohydrolase
SMALA_RS16430	COG2814	Major facilitator Superfamily
SMALA_RS16430	COG0477	Major facilitator Superfamily
SMALA_RS16440	COG1595	DNA-templated transcription, initiation
SMALA_RS16445	COG0745	RESPONSE REGULATOR receiver
SMALA_RS16450	COG2205	protein histidine kinase activity
SMALA_RS16475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMALA_RS16485	COG2814	Major facilitator Superfamily
SMALA_RS16490	COG0583	DNA-binding transcription factor activity
SMALA_RS16505	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS16510	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS16515	COG3845	ABC transporter
SMALA_RS16520	COG1744	ABC transporter substrate-binding protein PnrA-like
SMALA_RS16530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SMALA_RS16530	COG1473	amidohydrolase
SMALA_RS16540	COG2089	acid synthase
SMALA_RS16545	COG1083	cytidylyl-transferase
SMALA_RS16555	COG1216	Glycosyl transferase, family 2
SMALA_RS16565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMALA_RS16580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMALA_RS16590	COG1063	alcohol dehydrogenase
SMALA_RS16595	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS16605	COG3265	gluconokinase activity
SMALA_RS16610	COG2186	Transcriptional regulator
SMALA_RS16620	COG1316	TRANSCRIPTIONal
SMALA_RS16650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS16650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS16685	COG2009	succinate dehydrogenase
SMALA_RS16695	COG1053	succinate dehydrogenase
SMALA_RS16700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMALA_RS16710	COG1408	metallophosphoesterase
SMALA_RS16715	COG1686	Belongs to the peptidase S11 family
SMALA_RS16720	COG1295	ribonuclease BN
SMALA_RS16750	COG0180	Tryptophanyl-tRNA synthetase
SMALA_RS16755	COG1595	DNA-templated transcription, initiation
SMALA_RS16760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMALA_RS16775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMALA_RS16780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMALA_RS16785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMALA_RS16800	COG4176	ABC-type proline glycine betaine transport system permease component
SMALA_RS16805	COG4175	Glycine betaine
SMALA_RS16805	COG0517	IMP dehydrogenase activity
SMALA_RS16815	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS16840	COG0039	L-malate dehydrogenase activity
SMALA_RS16855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMALA_RS16860	COG0138	bifunctional purine biosynthesis protein purh
SMALA_RS16885	COG0045	succinate-CoA ligase (ADP-forming) activity
SMALA_RS16900	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SMALA_RS16910	COG0714	Associated with various cellular activities
SMALA_RS16925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS16935	COG0739	heme binding
SMALA_RS16965	COG0460	homoserine dehydrogenase
SMALA_RS16985	COG2197	response regulator
SMALA_RS17005	COG0515	serine threonine protein kinase
SMALA_RS17030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMALA_RS17030	COG0519	Catalyzes the synthesis of GMP from XMP
SMALA_RS17050	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS17055	COG0515	serine threonine protein kinase
SMALA_RS17060	COG0515	serine threonine protein kinase
SMALA_RS17080	COG2197	response regulator
SMALA_RS17085	COG3851	Histidine kinase
SMALA_RS17090	COG1366	Belongs to the anti-sigma-factor antagonist family
SMALA_RS17170	COG2945	thiolester hydrolase activity
SMALA_RS17170	COG0596	Alpha beta hydrolase
SMALA_RS17180	COG4821	SIS domain
SMALA_RS17190	COG0259	pyridoxamine-phosphate oxidase activity
SMALA_RS17210	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS17225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMALA_RS17260	COG2442	InterPro IPR007367
SMALA_RS17265	COG3344	reverse transcriptase
SMALA_RS17280	COG0247	lactate metabolic process
SMALA_RS17280	COG0277	FAD linked oxidase domain protein
SMALA_RS17285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMALA_RS17300	COG0667	Aldo Keto reductase
SMALA_RS17320	COG2252	PERMEase
SMALA_RS17350	COG2814	Major facilitator Superfamily
SMALA_RS17360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMALA_RS17365	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMALA_RS17370	COG1278	Cold shock
SMALA_RS17385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS17390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS17395	COG1120	ATPase activity
SMALA_RS17420	COG1061	Type III restriction enzyme res subunit
SMALA_RS17425	COG3973	AAA domain
SMALA_RS17430	COG3142	Participates in the control of copper homeostasis
SMALA_RS17460	COG0475	glutathione-regulated potassium exporter activity
SMALA_RS17470	COG3851	Histidine kinase
SMALA_RS17475	COG2197	response regulator
SMALA_RS17490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMALA_RS17495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SMALA_RS17500	COG0459	protein refolding
SMALA_RS17505	COG1278	Cold shock
SMALA_RS17520	COG0463	Glycosyl transferase, family 2
SMALA_RS17530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMALA_RS17530	COG1877	trehalose-phosphatase activity
SMALA_RS17545	COG1940	carbohydrate kinase activity
SMALA_RS17550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMALA_RS17570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMALA_RS17575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMALA_RS17590	COG1309	transcriptional regulator
SMALA_RS17595	COG1064	alcohol dehydrogenase
SMALA_RS17640	COG3842	ATPase activity
SMALA_RS17660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMALA_RS17665	COG0215	cysteine-tRNA ligase activity
SMALA_RS17670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMALA_RS17675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMALA_RS17680	COG1329	Transcriptional regulator
SMALA_RS17700	COG5002	protein histidine kinase activity
SMALA_RS17715	COG4249	Peptidase C14 caspase catalytic subunit p20
SMALA_RS17715	COG2319	Wd-40 repeat
SMALA_RS17730	COG1216	Glycosyl transferase, family 2
SMALA_RS17730	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS17735	COG2188	Transcriptional regulator
SMALA_RS17745	COG0640	Transcriptional regulator
SMALA_RS17780	COG0588	phosphoglycerate mutase activity
SMALA_RS17815	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS17835	COG0667	Aldo Keto reductase
SMALA_RS17850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMALA_RS17865	COG1126	abc transporter atp-binding protein
SMALA_RS17870	COG0406	alpha-ribazole phosphatase activity
SMALA_RS17870	COG0494	nUDIX hydrolase
SMALA_RS17880	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMALA_RS17885	COG0456	acetyltransferase
SMALA_RS17885	COG0454	-acetyltransferase
SMALA_RS17890	COG4804	nuclease activity
SMALA_RS17895	COG0737	Belongs to the 5'-nucleotidase family
SMALA_RS17910	COG1024	Enoyl-CoA hydratase
SMALA_RS17915	COG1733	regulation of RNA biosynthetic process
SMALA_RS17970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SMALA_RS17990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMALA_RS18000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMALA_RS18005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMALA_RS18030	COG2197	response regulator
SMALA_RS18045	COG0649	NAD binding
SMALA_RS18060	COG1174	glycine betaine transport
SMALA_RS18065	COG1174	glycine betaine transport
SMALA_RS18070	COG0517	IMP dehydrogenase activity
SMALA_RS18070	COG1125	glycine betaine transport
SMALA_RS18095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMALA_RS18100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMALA_RS18110	COG0302	gtp cyclohydrolase
SMALA_RS18125	COG0037	tRNA processing
SMALA_RS18135	COG2027	D-alanyl-D-alanine carboxypeptidase
SMALA_RS18140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMALA_RS18150	COG0586	Pfam SNARE associated Golgi protein
SMALA_RS18155	COG0789	Transcriptional regulator
SMALA_RS18165	COG0076	glutamate decarboxylase activity
SMALA_RS18190	COG2318	DinB family
SMALA_RS18195	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS18220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMALA_RS18220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMALA_RS18225	COG1077	Cell shape determining protein MreB Mrl
SMALA_RS18240	COG1595	DNA-templated transcription, initiation
SMALA_RS18255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SMALA_RS18310	COG0671	phosphoesterase, PA-phosphatase related
SMALA_RS18315	COG2197	response regulator
SMALA_RS18320	COG4585	Histidine kinase
SMALA_RS18350	COG1191	sigma factor activity
SMALA_RS18360	COG0640	Transcriptional regulator
SMALA_RS18375	COG2271	Major facilitator Superfamily
SMALA_RS18380	COG0006	proline dipeptidase activity
SMALA_RS18390	COG2423	ornithine cyclodeaminase activity
SMALA_RS18395	COG0066	3-isopropylmalate dehydratase activity
SMALA_RS18400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMALA_RS18405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMALA_RS18410	COG0066	3-isopropylmalate dehydratase activity
SMALA_RS18420	COG2271	Major facilitator Superfamily
SMALA_RS18425	COG0129	dihydroxy-acid dehydratase activity
SMALA_RS18430	COG3573	Dehydrogenase
SMALA_RS18465	COG0270	DNA (cytosine-5-)-methyltransferase activity
SMALA_RS18490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMALA_RS18495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMALA_RS18500	COG1754	DNA topoisomerase type I activity
SMALA_RS18500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMALA_RS18510	COG2890	protein-(glutamine-N5) methyltransferase activity
SMALA_RS18520	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMALA_RS18525	COG2172	sigma factor antagonist activity
SMALA_RS18530	COG1366	Belongs to the anti-sigma-factor antagonist family
SMALA_RS18595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS18600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMALA_RS18610	COG2267	carboxylic ester hydrolase activity
SMALA_RS18640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMALA_RS18665	COG0003	Pfam Anion-transporting ATPase
SMALA_RS18680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMALA_RS18690	COG1408	metallophosphoesterase
SMALA_RS18740	COG2124	cytochrome p450
SMALA_RS18785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMALA_RS18790	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMALA_RS18880	COG2188	Transcriptional regulator
SMALA_RS18920	COG4585	Histidine kinase
SMALA_RS18925	COG2197	response regulator
SMALA_RS18940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMALA_RS18985	COG0501	Belongs to the peptidase M48B family
SMALA_RS18995	COG2124	cytochrome p450
SMALA_RS19000	COG0702	epimerase
SMALA_RS19015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMALA_RS19050	COG0205	6-phosphofructokinase activity
SMALA_RS19055	COG1191	sigma factor activity
SMALA_RS19060	COG1191	sigma factor activity
SMALA_RS19095	COG0477	Major facilitator Superfamily
SMALA_RS19100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SMALA_RS19110	COG2205	protein histidine kinase activity
SMALA_RS19115	COG0745	RESPONSE REGULATOR receiver
SMALA_RS19175	COG5000	phosphorelay sensor kinase activity
SMALA_RS19180	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS19185	COG1595	DNA-templated transcription, initiation
SMALA_RS19235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMALA_RS19250	COG0653	protein targeting
SMALA_RS19265	COG0006	proline dipeptidase activity
SMALA_RS19270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMALA_RS19275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMALA_RS19295	COG1999	signal sequence binding
SMALA_RS19305	COG2372	response to copper ion
SMALA_RS19310	COG2837	iron assimilation
SMALA_RS19315	COG0077	Prephenate dehydratase
SMALA_RS19320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMALA_RS19325	COG0561	phosphatase activity
SMALA_RS19355	COG2807	transmembrane transport
SMALA_RS19375	COG1131	(ABC) transporter
SMALA_RS19385	COG0501	Belongs to the peptidase M48B family
SMALA_RS19395	COG0561	phosphatase activity
SMALA_RS19410	COG4988	ABC transporter
SMALA_RS19415	COG1294	oxidase, subunit
SMALA_RS19420	COG1271	oxidase subunit
SMALA_RS19425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMALA_RS19430	COG1609	Transcriptional regulator
SMALA_RS19450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMALA_RS19470	COG0662	Cupin 2, conserved barrel domain protein
SMALA_RS19475	COG1950	PFAM Membrane protein of
SMALA_RS19480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMALA_RS19485	COG0626	cystathionine gamma-synthase activity
SMALA_RS19550	COG0242	peptide deformylase activity
SMALA_RS19555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMALA_RS19560	COG0305	Participates in initiation and elongation during chromosome replication
SMALA_RS19570	COG0359	binds to the 23S rRNA
SMALA_RS19575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMALA_RS19580	COG0629	single-stranded DNA binding
SMALA_RS19585	COG0360	Binds together with S18 to 16S ribosomal RNA
SMALA_RS19610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMALA_RS19620	COG1260	myo-inositol-1-phosphate synthase
SMALA_RS19630	COG0617	tRNA 3'-terminal CCA addition
SMALA_RS19645	COG0515	serine threonine protein kinase
SMALA_RS19645	COG2815	serine threonine protein kinase
SMALA_RS19650	COG1595	DNA-templated transcription, initiation
SMALA_RS19660	COG0492	ferredoxin-NADP+ reductase activity
SMALA_RS19665	COG3118	belongs to the thioredoxin family
SMALA_RS19680	COG1192	Involved in chromosome partitioning
SMALA_RS19685	COG0357	Ribosomal RNA small subunit methyltransferase G
SMALA_RS19695	COG0706	membrane insertase activity
SMALA_RS19700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMALA_RS19705	COG0594	ribonuclease P activity
SMALA_RS19710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMALA_RS19725	COG0592	DNA-directed DNA polymerase activity
SMALA_RS19730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMALA_RS19735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMALA_RS19740	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SMALA_RS19745	COG0187	DNA topoisomerase II activity
SMALA_RS19750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMALA_RS19775	COG0515	serine threonine protein kinase
SMALA_RS19805	COG0705	Rhomboid family
SMALA_RS19820	COG3764	Sortase (surface protein transpeptidase)
SMALA_RS19840	COG3764	Sortase (surface protein transpeptidase)
SMALA_RS19845	COG0515	serine threonine protein kinase
SMALA_RS19850	COG0768	penicillin binding
SMALA_RS19865	COG1716	ATPase activity
SMALA_RS19870	COG1716	ATPase activity
SMALA_RS19880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMALA_RS19885	COG1733	regulation of RNA biosynthetic process
SMALA_RS19910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMALA_RS19915	COG2151	metal-sulfur cluster biosynthetic enzyme
SMALA_RS19920	COG3396	Phenylacetate-CoA oxygenase
SMALA_RS19925	COG3460	Phenylacetate-CoA oxygenase
SMALA_RS19930	COG3396	Phenylacetate-CoA oxygenase
SMALA_RS19955	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS19960	COG1309	transcriptional regulator
SMALA_RS19965	COG1522	sequence-specific DNA binding
SMALA_RS19985	COG0746	molybdenum cofactor guanylyltransferase activity
SMALA_RS19995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMALA_RS20000	COG0604	alcohol dehydrogenase
SMALA_RS20000	COG3321	synthase
SMALA_RS20000	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS20015	COG0515	serine threonine protein kinase
SMALA_RS20020	COG0515	serine threonine protein kinase
SMALA_RS20025	COG2826	transposase and inactivated derivatives, IS30 family
SMALA_RS20045	COG0022	dehydrogenase e1 component
SMALA_RS20050	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMALA_RS20095	COG1362	aminopeptidase activity
SMALA_RS20110	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS20120	COG1741	Belongs to the pirin family
SMALA_RS20140	COG2837	iron assimilation
SMALA_RS20150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMALA_RS20165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMALA_RS20200	COG1793	dna ligase
SMALA_RS20210	COG3290	protein histidine kinase activity
SMALA_RS20220	COG2018	Roadblock/LC7 domain
SMALA_RS20255	COG2197	response regulator
SMALA_RS20260	COG4585	Histidine kinase
SMALA_RS20305	COG2205	protein histidine kinase activity
SMALA_RS20335	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMALA_RS20365	COG0546	phosphoglycolate phosphatase activity
SMALA_RS20390	COG0531	amino acid
SMALA_RS20405	COG0583	DNA-binding transcription factor activity
SMALA_RS20430	COG0515	serine threonine protein kinase
SMALA_RS20430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMALA_RS20460	COG3903	Transcriptional regulator
SMALA_RS20460	COG3629	intracellular signal transduction
SMALA_RS20480	COG0726	polysaccharide deacetylase
SMALA_RS20505	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS20555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMALA_RS20565	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMALA_RS20615	COG0717	Belongs to the dCTP deaminase family
SMALA_RS20620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SMALA_RS20640	COG3290	protein histidine kinase activity
SMALA_RS20645	COG0247	lactate metabolic process
SMALA_RS20645	COG2181	nitrate reductase activity
SMALA_RS20650	COG0443	Heat shock 70 kDa protein
SMALA_RS20655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMALA_RS20660	COG0484	heat shock protein binding
SMALA_RS20665	COG0789	Transcriptional regulator
SMALA_RS20675	COG0477	Major facilitator Superfamily
SMALA_RS20685	COG0542	response to heat
SMALA_RS20730	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMALA_RS20745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMALA_RS20750	COG0191	fructose-bisphosphate aldolase activity
SMALA_RS20755	COG0477	Major facilitator Superfamily
SMALA_RS20770	COG3844	kynureninase activity
SMALA_RS20785	COG2197	response regulator
SMALA_RS20795	COG3559	Exporter of polyketide antibiotics
SMALA_RS20800	COG1131	(ABC) transporter
SMALA_RS20815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMALA_RS20820	COG0515	serine threonine protein kinase
SMALA_RS20820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMALA_RS20830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMALA_RS20835	COG1802	Transcriptional regulator
SMALA_RS20850	COG0151	Belongs to the GarS family
SMALA_RS20870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMALA_RS20900	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMALA_RS20905	COG0047	phosphoribosylformylglycinamidine synthase activity
SMALA_RS20910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMALA_RS20930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMALA_RS20940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMALA_RS20965	COG1643	Atp-dependent helicase
SMALA_RS21055	COG0513	Belongs to the DEAD box helicase family
SMALA_RS21100	COG0667	Aldo Keto reductase
SMALA_RS21170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMALA_RS21195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMALA_RS21200	COG0579	oxidoreductase
SMALA_RS21225	COG1252	NADH dehydrogenase
SMALA_RS21240	COG1846	Transcriptional regulator
SMALA_RS21300	COG1196	nuclear chromosome segregation
SMALA_RS21300	COG0741	lytic transglycosylase activity
SMALA_RS21300	COG0739	heme binding
SMALA_RS21305	COG0671	phosphoesterase, PA-phosphatase related
SMALA_RS21310	COG0277	FAD linked oxidase domain protein
SMALA_RS21330	COG1937	Protein conserved in bacteria
SMALA_RS21340	COG0306	phosphate transporter
SMALA_RS21345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMALA_RS21370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMALA_RS21400	COG4941	Belongs to the sigma-70 factor family
SMALA_RS21405	COG0667	Aldo Keto reductase
SMALA_RS21445	COG4552	Acetyltransferase involved in intracellular survival and related
SMALA_RS21455	COG1490	D-aminoacyl-tRNA deacylase activity
SMALA_RS21465	COG0735	belongs to the Fur family
SMALA_RS21470	COG3485	protocatechuate 3,4-dioxygenase
SMALA_RS21490	COG2897	thiosulfate sulfurtransferase activity
SMALA_RS21525	COG0745	RESPONSE REGULATOR receiver
SMALA_RS21530	COG1609	Transcriptional regulator
SMALA_RS21535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMALA_RS21560	COG0724	RNA recognition motif
SMALA_RS21610	COG0739	heme binding
SMALA_RS21630	COG0346	lactoylglutathione lyase activity
SMALA_RS21635	COG2205	protein histidine kinase activity
SMALA_RS21640	COG0745	RESPONSE REGULATOR receiver
SMALA_RS21650	COG1595	DNA-templated transcription, initiation
SMALA_RS21655	COG1194	a g-specific adenine glycosylase
SMALA_RS21665	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SMALA_RS21685	COG0248	Ppx GppA phosphatase
SMALA_RS21690	COG1082	Xylose isomerase domain protein TIM barrel
SMALA_RS21700	COG0129	dihydroxy-acid dehydratase activity
SMALA_RS21730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMALA_RS21735	COG0180	Tryptophanyl-tRNA synthetase
SMALA_RS21760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMALA_RS21770	COG0123	including yeast histone deacetylase and acetoin utilization protein
SMALA_RS21820	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMALA_RS21825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMALA_RS21830	COG0181	hydroxymethylbilane synthase activity
SMALA_RS21835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMALA_RS21835	COG1648	precorrin-2 dehydrogenase activity
SMALA_RS21840	COG0113	porphobilinogen synthase activity
SMALA_RS21845	COG1072	(Pantothenic acid kinase))
SMALA_RS21865	COG0018	arginyl-trna synthetase
SMALA_RS21870	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SMALA_RS21890	COG1690	Belongs to the RtcB family
SMALA_RS21900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMALA_RS21940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMALA_RS21945	COG0406	alpha-ribazole phosphatase activity
SMALA_RS21955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMALA_RS21965	COG1333	cytochrome c biogenesis protein
SMALA_RS21970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMALA_RS21980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMALA_RS21985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMALA_RS21990	COG0163	prenyltransferase activity
SMALA_RS22000	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMALA_RS22005	COG1573	uracil-dna glycosylase
SMALA_RS22020	COG1301	dicarboxylic acid transport
SMALA_RS22025	COG2076	Multidrug Resistance protein
SMALA_RS22035	COG1309	transcriptional regulator
SMALA_RS22055	COG1278	Cold shock
SMALA_RS22060	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMALA_RS22070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMALA_RS22080	COG2226	methyltransferase
SMALA_RS22110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMALA_RS22115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMALA_RS22120	COG0649	NAD binding
SMALA_RS22130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SMALA_RS22135	COG1034	ATP synthesis coupled electron transport
SMALA_RS22140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMALA_RS22145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMALA_RS22150	COG0839	Belongs to the complex I subunit 6 family
SMALA_RS22155	COG0713	ATP synthesis coupled electron transport
SMALA_RS22160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMALA_RS22170	COG1007	ATP synthesis coupled electron transport
SMALA_RS22190	COG0492	ferredoxin-NADP+ reductase activity
SMALA_RS22195	COG0142	geranyltranstransferase activity
SMALA_RS22230	COG0702	epimerase
SMALA_RS22240	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMALA_RS22245	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMALA_RS22245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMALA_RS22255	COG4585	Histidine kinase
SMALA_RS22260	COG4585	Histidine kinase
SMALA_RS22265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMALA_RS22270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMALA_RS22275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMALA_RS22280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMALA_RS22285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMALA_RS22290	COG0839	Belongs to the complex I subunit 6 family
SMALA_RS22295	COG0713	ATP synthesis coupled electron transport
SMALA_RS22300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMALA_RS22310	COG1007	ATP synthesis coupled electron transport
SMALA_RS22315	COG0501	Belongs to the peptidase M48B family
SMALA_RS22320	COG3304	Inner membrane component domain
SMALA_RS22325	COG1666	GTP binding
SMALA_RS22350	COG1970	mechanosensitive ion channel activity
SMALA_RS22365	COG0702	epimerase
SMALA_RS22385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMALA_RS22390	COG2030	dehydratase
SMALA_RS22400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMALA_RS22405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMALA_RS22410	COG0436	Aminotransferase
SMALA_RS22430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMALA_RS22435	COG0081	regulation of translation
SMALA_RS22445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMALA_RS22450	COG0222	ribosome binding
SMALA_RS22460	COG0085	RNA polymerase activity
SMALA_RS22465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMALA_RS22500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMALA_RS22505	COG0049	tRNA binding
SMALA_RS22510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMALA_RS22515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMALA_RS22530	COG0051	transcription antitermination factor activity, RNA binding
SMALA_RS22535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMALA_RS22540	COG0088	Forms part of the polypeptide exit tunnel
SMALA_RS22545	COG0089	rRNA binding
SMALA_RS22550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMALA_RS22555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMALA_RS22560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMALA_RS22565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMALA_RS22570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMALA_RS22575	COG0255	Belongs to the universal ribosomal protein uL29 family
SMALA_RS22580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMALA_RS22585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMALA_RS22590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMALA_RS22595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMALA_RS22600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMALA_RS22610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMALA_RS22615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMALA_RS22620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMALA_RS22625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMALA_RS22635	COG0200	Binds to the 23S rRNA
SMALA_RS22645	COG0563	adenylate kinase activity
SMALA_RS22655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMALA_RS22660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMALA_RS22665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMALA_RS22670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMALA_RS22675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMALA_RS22680	COG0202	RNA polymerase activity
SMALA_RS22685	COG0203	ribosomal protein L17
SMALA_RS22690	COG0101	tRNA pseudouridine synthase activity
SMALA_RS22695	COG1366	Belongs to the anti-sigma-factor antagonist family
SMALA_RS22700	COG1366	Belongs to the anti-sigma-factor antagonist family
SMALA_RS22705	COG2172	sigma factor antagonist activity
SMALA_RS22715	COG2208	phosphoserine phosphatase activity
SMALA_RS22715	COG2770	Histidine kinase
SMALA_RS22740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMALA_RS22745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMALA_RS22750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMALA_RS22760	COG1072	(Pantothenic acid kinase))
SMALA_RS22765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMALA_RS22770	COG0736	holo-[acyl-carrier-protein] synthase activity
SMALA_RS22795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMALA_RS22810	COG0802	atpase or kinase
SMALA_RS22835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMALA_RS22845	COG0583	DNA-binding transcription factor activity
SMALA_RS22850	COG0667	Aldo Keto reductase
SMALA_RS22855	COG3903	Transcriptional regulator
SMALA_RS22855	COG3629	intracellular signal transduction
SMALA_RS22860	COG0596	Alpha beta hydrolase
SMALA_RS22910	COG0726	polysaccharide deacetylase
SMALA_RS22915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMALA_RS22920	COG0459	protein refolding
SMALA_RS22925	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS22935	COG0583	DNA-binding transcription factor activity
SMALA_RS22945	COG2197	response regulator
SMALA_RS22950	COG1595	DNA-templated transcription, initiation
SMALA_RS22960	COG0516	GMP reductase activity
SMALA_RS22975	COG1077	Cell shape determining protein MreB Mrl
SMALA_RS22990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMALA_RS23010	COG3547	Transposase (IS116 IS110 IS902 family)
SMALA_RS23015	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS23020	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS23025	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS23040	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS23045	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS23070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMALA_RS23075	COG1024	Enoyl-CoA hydratase
SMALA_RS23085	COG2072	flavoprotein involved in K transport
SMALA_RS23100	COG0259	pyridoxamine-phosphate oxidase activity
SMALA_RS23110	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS23120	COG1309	transcriptional regulator
SMALA_RS23130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMALA_RS23130	COG0515	serine threonine protein kinase
SMALA_RS23145	COG1024	Enoyl-CoA hydratase
SMALA_RS23225	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMALA_RS23275	COG1686	Belongs to the peptidase S11 family
SMALA_RS23285	COG1653	transport
SMALA_RS23300	COG0515	serine threonine protein kinase
SMALA_RS23320	COG1309	transcriptional regulator
SMALA_RS23330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SMALA_RS23335	COG1793	dna ligase
SMALA_RS23335	COG3285	dna ligase
SMALA_RS23340	COG1793	dna ligase
SMALA_RS23345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SMALA_RS23350	COG0640	Transcriptional regulator
SMALA_RS23365	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS23365	COG0824	Thioesterase
SMALA_RS23370	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS23375	COG3246	L-lysine catabolic process to acetate
SMALA_RS23385	COG0515	serine threonine protein kinase
SMALA_RS23400	COG0596	Alpha beta hydrolase
SMALA_RS23425	COG0640	Transcriptional regulator
SMALA_RS23445	COG0395	ABC-type sugar transport system, permease component
SMALA_RS23450	COG1175	transmembrane transport
SMALA_RS23475	COG0494	nUDIX hydrolase
SMALA_RS23480	COG0494	nUDIX hydrolase
SMALA_RS23515	COG4221	oxidoreductase activity
SMALA_RS23545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SMALA_RS23590	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SMALA_RS23650	COG1846	Transcriptional regulator
SMALA_RS23655	COG3384	dioxygenase
SMALA_RS23675	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS23680	COG1349	DNA-binding transcription factor activity
SMALA_RS23685	COG1105	Belongs to the carbohydrate kinase PfkB family
SMALA_RS23690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMALA_RS23690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SMALA_RS23690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMALA_RS23695	COG1233	COG1233 Phytoene dehydrogenase and related
SMALA_RS23700	COG3191	aminopeptidase activity
SMALA_RS23705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS23715	COG1970	mechanosensitive ion channel activity
SMALA_RS23725	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMALA_RS23735	COG3263	regulation of cellular component size
SMALA_RS23745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMALA_RS23750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMALA_RS23760	COG0315	cyclic pyranopterin monophosphate synthase activity
SMALA_RS23765	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMALA_RS23770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMALA_RS23785	COG0783	Belongs to the Dps family
SMALA_RS23805	COG0708	Exodeoxyribonuclease III
SMALA_RS23810	COG0789	Transcriptional regulator
SMALA_RS23815	COG2072	flavoprotein involved in K transport
SMALA_RS23820	COG2267	carboxylic ester hydrolase activity
SMALA_RS23835	COG4946	Tricorn protease homolog
SMALA_RS23835	COG0793	Belongs to the peptidase S41A family
SMALA_RS23845	COG2409	Drug exporters of the RND superfamily
SMALA_RS23850	COG1309	transcriptional regulator
SMALA_RS23860	COG0310	cobalt ion transport
SMALA_RS23870	COG1122	ATPase activity
SMALA_RS23885	COG4166	transmembrane transport
SMALA_RS23945	COG0084	hydrolase, TatD family'
SMALA_RS23950	COG3584	3D domain protein
SMALA_RS23950	COG3583	domain protein
SMALA_RS23955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMALA_RS23960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMALA_RS23965	COG0488	(ABC) transporter
SMALA_RS24000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMALA_RS24005	COG2197	response regulator
SMALA_RS24015	COG4106	trans-aconitate 2-methyltransferase activity
SMALA_RS24025	COG1309	transcriptional regulator
SMALA_RS24035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMALA_RS24045	COG0193	aminoacyl-tRNA hydrolase activity
SMALA_RS24050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMALA_RS24055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMALA_RS24060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMALA_RS24070	COG4585	Histidine kinase
SMALA_RS24100	COG0477	Major facilitator Superfamily
SMALA_RS24105	COG1136	(ABC) transporter
SMALA_RS24110	COG0577	efflux transmembrane transporter activity
SMALA_RS24175	COG2376	Dihydroxyacetone kinase
SMALA_RS24180	COG0698	ribose 5-phosphate isomerase
SMALA_RS24185	COG0149	triose-phosphate isomerase activity
SMALA_RS24190	COG1082	Xylose isomerase domain protein TIM barrel
SMALA_RS24195	COG2084	Dehydrogenase
SMALA_RS24235	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS24245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS24250	COG0601	transmembrane transport
SMALA_RS24275	COG2226	methyltransferase
SMALA_RS24345	COG2318	DinB family
SMALA_RS24350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMALA_RS24380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMALA_RS24395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMALA_RS24405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMALA_RS24415	COG3629	intracellular signal transduction
SMALA_RS24415	COG3903	Transcriptional regulator
SMALA_RS24420	COG1331	Highly conserved protein containing a thioredoxin domain
SMALA_RS24430	COG1272	protein, Hemolysin III
SMALA_RS24435	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SMALA_RS24455	COG0601	transmembrane transport
SMALA_RS24460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS24490	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SMALA_RS24505	COG1414	Transcriptional regulator
SMALA_RS24510	COG0251	oxidation-reduction process
SMALA_RS24515	COG2610	gluconate transmembrane transporter activity
SMALA_RS24520	COG1131	(ABC) transporter
SMALA_RS24540	COG1278	Cold shock
SMALA_RS24545	COG0513	Belongs to the DEAD box helicase family
SMALA_RS24610	COG2894	cell division
SMALA_RS24645	COG2885	chlorophyll binding
SMALA_RS24650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMALA_RS24655	COG1278	Cold shock
SMALA_RS24670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMALA_RS24675	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SMALA_RS24700	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SMALA_RS24710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMALA_RS24740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMALA_RS24745	COG0450	alkyl hydroperoxide reductase
SMALA_RS24760	COG1136	(ABC) transporter
SMALA_RS24780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMALA_RS24800	COG3409	Peptidoglycan-binding domain 1 protein
SMALA_RS24820	COG1082	Xylose isomerase domain protein TIM barrel
SMALA_RS24820	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SMALA_RS24825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMALA_RS24830	COG1309	transcriptional regulator
SMALA_RS24840	COG2264	protein methyltransferase activity
SMALA_RS24850	COG0114	fumarate hydratase activity
SMALA_RS24865	COG3979	chitinase
SMALA_RS24895	COG4106	trans-aconitate 2-methyltransferase activity
SMALA_RS24925	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMALA_RS24925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMALA_RS24950	COG0778	Nitroreductase
SMALA_RS24955	COG1722	exodeoxyribonuclease VII activity
SMALA_RS24960	COG1570	exodeoxyribonuclease VII activity
SMALA_RS24965	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMALA_RS24980	COG0012	GTP binding
SMALA_RS24985	COG3547	Transposase (IS116 IS110 IS902 family)
SMALA_RS25005	COG1136	(ABC) transporter
SMALA_RS25045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMALA_RS25125	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS25130	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMALA_RS25135	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS25175	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS25215	COG0583	DNA-binding transcription factor activity
SMALA_RS25225	COG0243	molybdopterin cofactor binding
SMALA_RS25230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMALA_RS25250	COG4106	trans-aconitate 2-methyltransferase activity
SMALA_RS25250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMALA_RS25260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMALA_RS25265	COG0066	3-isopropylmalate dehydratase activity
SMALA_RS25375	COG1136	(ABC) transporter
SMALA_RS25375	COG0577	efflux transmembrane transporter activity
SMALA_RS25400	COG2205	protein histidine kinase activity
SMALA_RS25410	COG0745	RESPONSE REGULATOR receiver
SMALA_RS25425	COG2161	toxin-antitoxin pair type II binding
SMALA_RS25430	COG4115	mRNA cleavage
SMALA_RS25445	COG1063	alcohol dehydrogenase
SMALA_RS25450	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMALA_RS25465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMALA_RS25470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMALA_RS25495	COG2223	nitrite transmembrane transporter activity
SMALA_RS25545	COG1053	succinate dehydrogenase
SMALA_RS25565	COG1217	gtp-binding protein TYPA
SMALA_RS25575	COG0601	transmembrane transport
SMALA_RS25580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS25585	COG0444	Belongs to the ABC transporter superfamily
SMALA_RS25590	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS25620	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS25625	COG0444	Belongs to the ABC transporter superfamily
SMALA_RS25630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS25635	COG0601	transmembrane transport
SMALA_RS25640	COG4166	transmembrane transport
SMALA_RS25645	COG0596	Alpha beta hydrolase
SMALA_RS25660	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS25665	COG0444	Belongs to the ABC transporter superfamily
SMALA_RS25675	COG0747	negative chemotaxis
SMALA_RS25680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS25700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMALA_RS25720	COG1131	(ABC) transporter
SMALA_RS25730	COG4585	Histidine kinase
SMALA_RS25735	COG2197	response regulator
SMALA_RS25740	COG2912	Transglutaminase-like superfamily
SMALA_RS25775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMALA_RS25780	COG1611	Belongs to the LOG family
SMALA_RS25785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMALA_RS25795	COG0519	Catalyzes the synthesis of GMP from XMP
SMALA_RS25800	COG1024	Enoyl-CoA hydratase
SMALA_RS25815	COG1595	DNA-templated transcription, initiation
SMALA_RS25825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMALA_RS25830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMALA_RS25870	COG0598	Magnesium transport protein CorA
SMALA_RS25885	COG0613	PHP domain protein
SMALA_RS25890	COG2095	MarC family integral membrane protein
SMALA_RS25900	COG1432	Conserved Protein
SMALA_RS26000	COG0210	DNA helicase
SMALA_RS26045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMALA_RS26100	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMALA_RS26110	COG1615	UPF0182 protein
SMALA_RS26135	COG0753	catalase activity
SMALA_RS26145	COG0483	inositol monophosphate 1-phosphatase activity
SMALA_RS26160	COG1162	GTPase activity
SMALA_RS26165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMALA_RS26175	COG2135	peptidase activity
SMALA_RS26185	COG1595	DNA-templated transcription, initiation
SMALA_RS26190	COG5662	AntiSigma factor
SMALA_RS26195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMALA_RS26195	COG2199	diguanylate cyclase activity
SMALA_RS26210	COG0242	peptide deformylase activity
SMALA_RS26215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMALA_RS26295	COG2188	Transcriptional regulator
SMALA_RS26300	COG2182	Extracellular solute-binding protein
SMALA_RS26305	COG1175	transmembrane transport
SMALA_RS26310	COG0395	ABC-type sugar transport system, permease component
SMALA_RS26315	COG1472	Belongs to the glycosyl hydrolase 3 family
SMALA_RS26320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMALA_RS26335	COG1597	lipid kinase activity
SMALA_RS26375	COG2066	Belongs to the glutaminase family
SMALA_RS26395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMALA_RS26420	COG5640	endopeptidase activity
SMALA_RS26425	COG0583	DNA-binding transcription factor activity
SMALA_RS26475	COG0765	amino acid transport
SMALA_RS26485	COG0281	malic enzyme
SMALA_RS26510	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS26510	COG3321	synthase
SMALA_RS26510	COG0300	oxidoreductase activity
SMALA_RS26510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS26510	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS26525	COG0778	Nitroreductase
SMALA_RS26550	COG0789	Transcriptional regulator
SMALA_RS26560	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMALA_RS26560	COG0567	Dehydrogenase, E1 component
SMALA_RS26565	COG2205	protein histidine kinase activity
SMALA_RS26570	COG0745	RESPONSE REGULATOR receiver
SMALA_RS26585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMALA_RS26635	COG0791	NLP P60 protein
SMALA_RS26635	COG1388	LysM domain
SMALA_RS26635	COG3103	Sh3 type 3 domain protein
SMALA_RS26675	COG0477	Major facilitator Superfamily
SMALA_RS26810	COG0745	RESPONSE REGULATOR receiver
SMALA_RS26815	COG0018	arginyl-trna synthetase
SMALA_RS26820	COG0019	diaminopimelate decarboxylase activity
SMALA_RS26825	COG0460	homoserine dehydrogenase
SMALA_RS26830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMALA_RS26835	COG0083	homoserine kinase activity
SMALA_RS26845	COG1316	TRANSCRIPTIONal
SMALA_RS26850	COG0254	rRNA binding
SMALA_RS26855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMALA_RS26860	COG2890	protein-(glutamine-N5) methyltransferase activity
SMALA_RS26870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMALA_RS26875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMALA_RS26895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMALA_RS26900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMALA_RS26905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMALA_RS26910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMALA_RS26915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMALA_RS26920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMALA_RS26925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMALA_RS26935	COG2197	response regulator
SMALA_RS26940	COG4585	Histidine kinase
SMALA_RS26970	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS26990	COG0667	Aldo Keto reductase
SMALA_RS27000	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SMALA_RS27050	COG0183	Belongs to the thiolase family
SMALA_RS27065	COG0745	RESPONSE REGULATOR receiver
SMALA_RS27070	COG2205	protein histidine kinase activity
SMALA_RS27125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS27125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS27165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMALA_RS27170	COG0857	belongs to the CobB CobQ family
SMALA_RS27170	COG0280	phosphate acetyltransferase
SMALA_RS27175	COG0205	6-phosphofructokinase activity
SMALA_RS27195	COG3833	ABC-type maltose transport systems, permease component
SMALA_RS27210	COG1316	TRANSCRIPTIONal
SMALA_RS27230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS27235	COG1309	transcriptional regulator
SMALA_RS27265	COG1175	transmembrane transport
SMALA_RS27275	COG3469	chitinase activity
SMALA_RS27280	COG4565	transcriptional regulatory protein
SMALA_RS27285	COG3290	protein histidine kinase activity
SMALA_RS27290	COG1301	dicarboxylic acid transport
SMALA_RS27300	COG3903	Transcriptional regulator
SMALA_RS27300	COG3629	intracellular signal transduction
SMALA_RS27305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMALA_RS27310	COG3281	Trehalose synthase
SMALA_RS27320	COG0366	Alpha amylase catalytic
SMALA_RS27340	COG3401	FG-GAP repeat protein
SMALA_RS27345	COG0058	SHG alpha-glucan phosphorylase activity
SMALA_RS27360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMALA_RS27370	COG3344	reverse transcriptase
SMALA_RS27395	COG3340	Belongs to the peptidase S51 family
SMALA_RS27425	COG1132	(ABC) transporter
SMALA_RS27430	COG1132	(ABC) transporter
SMALA_RS27480	COG1597	lipid kinase activity
SMALA_RS27495	COG1846	Transcriptional regulator
SMALA_RS27500	COG1595	DNA-templated transcription, initiation
SMALA_RS27510	COG1760	l-serine dehydratase
SMALA_RS27515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMALA_RS27520	COG0509	glycine decarboxylation via glycine cleavage system
SMALA_RS27525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMALA_RS27550	COG4166	transmembrane transport
SMALA_RS27560	COG0444	Belongs to the ABC transporter superfamily
SMALA_RS27565	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS27570	COG2860	membrane
SMALA_RS27585	COG0596	Alpha beta hydrolase
SMALA_RS27610	COG0482	sulfurtransferase activity
SMALA_RS27620	COG0789	Transcriptional regulator
SMALA_RS27625	COG1819	glycosyl
SMALA_RS27635	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS27645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMALA_RS27655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMALA_RS27660	COG0154	amidase activity
SMALA_RS27670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMALA_RS27680	COG2409	Drug exporters of the RND superfamily
SMALA_RS27690	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMALA_RS27690	COG1672	PFAM Archaeal ATPase
SMALA_RS27695	COG2133	pyrroloquinoline quinone binding
SMALA_RS27700	COG0667	Aldo Keto reductase
SMALA_RS27720	COG0440	acetolactate synthase activity
SMALA_RS27725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMALA_RS27730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMALA_RS27780	COG0506	proline dehydrogenase activity
SMALA_RS27785	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS27800	COG0473	3-isopropylmalate dehydrogenase activity
SMALA_RS27805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMALA_RS27810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMALA_RS27815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMALA_RS27835	COG2018	Roadblock/LC7 domain
SMALA_RS27855	COG2018	Roadblock/LC7 domain
SMALA_RS27860	COG5002	protein histidine kinase activity
SMALA_RS27870	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMALA_RS27875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMALA_RS27915	COG1414	Transcriptional regulator
SMALA_RS27920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMALA_RS27925	COG0066	3-isopropylmalate dehydratase activity
SMALA_RS27935	COG0776	regulation of translation
SMALA_RS27940	COG1920	GTP binding
SMALA_RS27950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMALA_RS27955	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMALA_RS27975	COG0351	phosphomethylpyrimidine kinase
SMALA_RS27980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMALA_RS27985	COG1461	Dihydroxyacetone kinase
SMALA_RS27990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMALA_RS27995	COG0742	ribosomal rna small subunit methyltransferase
SMALA_RS28000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMALA_RS28015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMALA_RS28020	COG0571	ribonuclease III activity
SMALA_RS28025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMALA_RS28030	COG1733	regulation of RNA biosynthetic process
SMALA_RS28035	COG2340	Cysteine-rich secretory protein family
SMALA_RS28040	COG1254	Belongs to the acylphosphatase family
SMALA_RS28050	COG1196	nuclear chromosome segregation
SMALA_RS28055	COG0477	Major facilitator Superfamily
SMALA_RS28075	COG4585	Histidine kinase
SMALA_RS28080	COG2197	response regulator
SMALA_RS28110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMALA_RS28125	COG0442	prolyl-tRNA aminoacylation
SMALA_RS28135	COG0228	four-way junction DNA binding
SMALA_RS28140	COG1837	Belongs to the UPF0109 family
SMALA_RS28145	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMALA_RS28150	COG0336	Belongs to the RNA methyltransferase TrmD family
SMALA_RS28155	COG0335	large ribosomal subunit rRNA binding
SMALA_RS28160	COG0681	Belongs to the peptidase S26 family
SMALA_RS28165	COG0681	Belongs to the peptidase S26 family
SMALA_RS28170	COG0681	Belongs to the peptidase S26 family
SMALA_RS28175	COG0681	Belongs to the peptidase S26 family
SMALA_RS28180	COG1051	belongs to the nudix hydrolase family
SMALA_RS28190	COG0792	nuclease activity
SMALA_RS28210	COG1191	sigma factor activity
SMALA_RS28225	COG0052	Belongs to the universal ribosomal protein uS2 family
SMALA_RS28230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMALA_RS28235	COG0528	UMP kinase activity
SMALA_RS28240	COG0233	cytoplasmic translational termination
SMALA_RS28245	COG0575	Belongs to the CDS family
SMALA_RS28250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMALA_RS28260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SMALA_RS28265	COG3842	ATPase activity
SMALA_RS28280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMALA_RS28285	COG0028	Belongs to the TPP enzyme family
SMALA_RS28300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMALA_RS28310	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS28325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMALA_RS28335	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS28345	COG3842	ATPase activity
SMALA_RS28350	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMALA_RS28355	COG1177	transmembrane transport
SMALA_RS28360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMALA_RS28380	COG2508	Transcriptional regulator
SMALA_RS28385	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS28405	COG1609	Transcriptional regulator
SMALA_RS28415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMALA_RS28420	COG0750	zinc metalloprotease
SMALA_RS28425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMALA_RS28440	COG0442	prolyl-tRNA aminoacylation
SMALA_RS28460	COG0779	Required for maturation of 30S ribosomal subunits
SMALA_RS28475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMALA_RS28485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMALA_RS28490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMALA_RS28500	COG0455	bacterial-type flagellum organization
SMALA_RS28520	COG1404	Belongs to the peptidase S8 family
SMALA_RS28570	COG1674	ftsk spoiiie
SMALA_RS28585	COG1404	Belongs to the peptidase S8 family
SMALA_RS28605	COG1674	ftsk spoiiie
SMALA_RS28630	COG0515	serine threonine protein kinase
SMALA_RS28630	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMALA_RS28640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMALA_RS28645	COG1185	polyribonucleotide nucleotidyltransferase activity
SMALA_RS28650	COG0612	Peptidase, M16
SMALA_RS28655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMALA_RS28675	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMALA_RS28680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMALA_RS28685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMALA_RS28720	COG2208	phosphoserine phosphatase activity
SMALA_RS28720	COG2770	Histidine kinase
SMALA_RS28725	COG3850	Histidine kinase
SMALA_RS28725	COG3437	response regulator, receiver
SMALA_RS28725	COG4999	Histidine kinase
SMALA_RS28725	COG2205	protein histidine kinase activity
SMALA_RS28735	COG1674	ftsk spoiiie
SMALA_RS28745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMALA_RS28755	COG1546	Belongs to the CinA family
SMALA_RS28755	COG1058	Belongs to the CinA family
SMALA_RS28760	COG1396	sequence-specific DNA binding
SMALA_RS28775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMALA_RS28780	COG1201	RNA secondary structure unwinding
SMALA_RS28825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMALA_RS28835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS28840	COG0765	amino acid transport
SMALA_RS28845	COG0765	amino acid transport
SMALA_RS28850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SMALA_RS28855	COG1126	abc transporter atp-binding protein
SMALA_RS28860	COG0745	RESPONSE REGULATOR receiver
SMALA_RS28865	COG2205	protein histidine kinase activity
SMALA_RS28870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMALA_RS28880	COG1414	Transcriptional regulator
SMALA_RS28885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMALA_RS28905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMALA_RS28915	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMALA_RS28920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMALA_RS28930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMALA_RS28960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMALA_RS28965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMALA_RS28970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMALA_RS28985	COG0488	(ABC) transporter
SMALA_RS29000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMALA_RS29035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMALA_RS29040	COG1802	Transcriptional regulator
SMALA_RS29045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMALA_RS29060	COG0187	DNA topoisomerase II activity
SMALA_RS29070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMALA_RS29075	COG4565	transcriptional regulatory protein
SMALA_RS29080	COG3290	protein histidine kinase activity
SMALA_RS29095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMALA_RS29100	COG0612	Peptidase, M16
SMALA_RS29115	COG1802	Transcriptional regulator
SMALA_RS29120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMALA_RS29125	COG1042	CoA-binding domain protein
SMALA_RS29125	COG0045	succinate-CoA ligase (ADP-forming) activity
SMALA_RS29125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMALA_RS29140	COG1435	thymidine kinase activity
SMALA_RS29175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMALA_RS29180	COG0483	inositol monophosphate 1-phosphatase activity
SMALA_RS29185	COG0745	RESPONSE REGULATOR receiver
SMALA_RS29190	COG2205	protein histidine kinase activity
SMALA_RS29215	COG0756	dUTP diphosphatase activity
SMALA_RS29255	COG0569	domain protein
SMALA_RS29290	COG0531	amino acid
SMALA_RS29295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMALA_RS29305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMALA_RS29310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMALA_RS29335	COG2124	cytochrome p450
SMALA_RS29350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMALA_RS29405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS29410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS29415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS29420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS29440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS29445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMALA_RS29450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMALA_RS29455	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS29465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS29475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS29485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS29490	COG2124	cytochrome p450
SMALA_RS29520	COG1233	COG1233 Phytoene dehydrogenase and related
SMALA_RS29535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMALA_RS29545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMALA_RS29555	COG1819	glycosyl
SMALA_RS29560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMALA_RS29570	COG2409	Drug exporters of the RND superfamily
SMALA_RS29600	COG2040	homocysteine
SMALA_RS29605	COG4977	sequence-specific DNA binding
SMALA_RS29635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMALA_RS29650	COG3386	PFAM SMP-30 Gluconolaconase
SMALA_RS29655	COG0800	Aldolase
SMALA_RS29665	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS29675	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS29685	COG0395	ABC-type sugar transport system, permease component
SMALA_RS29690	COG1175	transmembrane transport
SMALA_RS29700	COG3345	alpha-galactosidase
SMALA_RS29705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMALA_RS29730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMALA_RS29740	COG3537	Alpha-1,2-mannosidase
SMALA_RS29765	COG1653	transport
SMALA_RS29770	COG1175	transmembrane transport
SMALA_RS29775	COG0395	ABC-type sugar transport system, permease component
SMALA_RS29780	COG1940	carbohydrate kinase activity
SMALA_RS29785	COG4213	ABC transporter substrate-binding protein
SMALA_RS29795	COG4214	carbohydrate transport
SMALA_RS29800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMALA_RS29805	COG0531	amino acid
SMALA_RS29820	COG1024	Enoyl-CoA hydratase
SMALA_RS29820	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS29825	COG0183	Belongs to the thiolase family
SMALA_RS29845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMALA_RS29855	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMALA_RS29860	COG2271	Major facilitator Superfamily
SMALA_RS29885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMALA_RS29890	COG3253	May function as heme-dependent peroxidase
SMALA_RS29910	COG3220	belongs to the UPF0276 family
SMALA_RS29915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMALA_RS29970	COG0745	RESPONSE REGULATOR receiver
SMALA_RS29975	COG5002	protein histidine kinase activity
SMALA_RS30020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMALA_RS30025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMALA_RS30150	COG1119	ATPase activity
SMALA_RS30170	COG1175	transmembrane transport
SMALA_RS30190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMALA_RS30195	COG2409	Drug exporters of the RND superfamily
SMALA_RS30240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS30245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SMALA_RS30265	COG0529	Catalyzes the synthesis of activated sulfate
SMALA_RS30270	COG0175	sulfate reduction
SMALA_RS30310	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SMALA_RS30345	COG1162	GTPase activity
SMALA_RS30355	COG0583	DNA-binding transcription factor activity
SMALA_RS30365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMALA_RS30375	COG0028	Belongs to the TPP enzyme family
SMALA_RS30390	COG0698	ribose 5-phosphate isomerase
SMALA_RS30395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMALA_RS30430	COG1802	Transcriptional regulator
SMALA_RS30460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS30475	COG0823	Involved in the tonB-independent uptake of proteins
SMALA_RS30480	COG0598	Magnesium transport protein CorA
SMALA_RS30485	COG2197	response regulator
SMALA_RS30490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS30495	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS30520	COG2351	hydroxyisourate hydrolase activity
SMALA_RS30535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMALA_RS30540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMALA_RS30550	COG1414	Transcriptional regulator
SMALA_RS30555	COG1953	Uracil, thiamine, allantoin
SMALA_RS30560	COG4266	Belongs to the allantoicase family
SMALA_RS30565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMALA_RS30605	COG0800	Aldolase
SMALA_RS30625	COG2188	Transcriptional regulator
SMALA_RS30645	COG1940	carbohydrate kinase activity
SMALA_RS30655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMALA_RS30680	COG1126	abc transporter atp-binding protein
SMALA_RS30685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMALA_RS30690	COG0765	amino acid transport
SMALA_RS30695	COG0765	amino acid transport
SMALA_RS30730	COG0405	Gamma-glutamyltransferase
SMALA_RS30735	COG1335	isochorismatase
SMALA_RS30740	COG0477	Major facilitator Superfamily
SMALA_RS30760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMALA_RS30765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMALA_RS30785	COG0483	inositol monophosphate 1-phosphatase activity
SMALA_RS30795	COG0181	hydroxymethylbilane synthase activity
SMALA_RS30830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMALA_RS30855	COG1929	Belongs to the glycerate kinase type-1 family
SMALA_RS30865	COG0688	phosphatidylethanolamine metabolic process
SMALA_RS30870	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS30880	COG2301	Belongs to the HpcH HpaI aldolase family
SMALA_RS30885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS30885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMALA_RS30895	COG1309	transcriptional regulator
SMALA_RS30900	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS30925	COG2208	phosphoserine phosphatase activity
SMALA_RS30925	COG1366	Belongs to the anti-sigma-factor antagonist family
SMALA_RS30925	COG2172	sigma factor antagonist activity
SMALA_RS30935	COG2362	D-Aminopeptidase
SMALA_RS30940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMALA_RS30980	COG4106	trans-aconitate 2-methyltransferase activity
SMALA_RS30985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMALA_RS30985	COG0517	IMP dehydrogenase activity
SMALA_RS30985	COG0617	tRNA 3'-terminal CCA addition
SMALA_RS31015	COG0693	protein deglycase activity
SMALA_RS31020	COG0028	Belongs to the TPP enzyme family
SMALA_RS31025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS31085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS31120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMALA_RS31135	COG2267	carboxylic ester hydrolase activity
SMALA_RS31160	COG1879	ABC-type sugar transport system periplasmic component
SMALA_RS31170	COG4214	carbohydrate transport
SMALA_RS31195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMALA_RS31210	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMALA_RS31225	COG1595	DNA-templated transcription, initiation
SMALA_RS31235	COG0656	L-ascorbic acid biosynthetic process
SMALA_RS31255	COG0583	DNA-binding transcription factor activity
SMALA_RS31275	COG0789	Transcriptional regulator
SMALA_RS31285	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS31295	COG1309	transcriptional regulator
SMALA_RS31300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMALA_RS31315	COG3383	formate dehydrogenase (NAD+) activity
SMALA_RS31320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMALA_RS31340	COG1940	carbohydrate kinase activity
SMALA_RS31345	COG1129	ABC transporter
SMALA_RS31350	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS31355	COG1879	ABC-type sugar transport system periplasmic component
SMALA_RS31360	COG0673	inositol 2-dehydrogenase activity
SMALA_RS31430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMALA_RS31440	COG0045	succinate-CoA ligase (ADP-forming) activity
SMALA_RS31450	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS31480	COG1920	GTP binding
SMALA_RS31485	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMALA_RS31490	COG2814	Major facilitator Superfamily
SMALA_RS31495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SMALA_RS31500	COG2188	Transcriptional regulator
SMALA_RS31505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS31515	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS31540	COG0693	protein deglycase activity
SMALA_RS31550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMALA_RS31560	COG1309	transcriptional regulator
SMALA_RS31565	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMALA_RS31565	COG0596	Alpha beta hydrolase
SMALA_RS31575	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMALA_RS31580	COG0697	spore germination
SMALA_RS31585	COG1846	Transcriptional regulator
SMALA_RS31590	COG1414	Transcriptional regulator
SMALA_RS31595	COG1027	Aspartate ammonia-lyase
SMALA_RS31600	COG2271	Major facilitator Superfamily
SMALA_RS31635	COG2239	Acts as a magnesium transporter
SMALA_RS31645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SMALA_RS31655	COG0697	spore germination
SMALA_RS31660	COG0583	DNA-binding transcription factor activity
SMALA_RS31685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMALA_RS31690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SMALA_RS31705	COG1309	transcriptional regulator
SMALA_RS31720	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMALA_RS31725	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMALA_RS31730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMALA_RS31810	COG0601	transmembrane transport
SMALA_RS31815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS31830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS31840	COG0431	NADPH-dependent FMN reductase
SMALA_RS31860	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS31920	COG1515	deoxyribonuclease V activity
SMALA_RS31930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMALA_RS31940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMALA_RS31945	COG0183	Belongs to the thiolase family
SMALA_RS31950	COG1024	Enoyl-CoA hydratase
SMALA_RS31950	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMALA_RS31955	COG0583	DNA-binding transcription factor activity
SMALA_RS31970	COG3250	beta-galactosidase activity
SMALA_RS31980	COG0308	aminopeptidase N
SMALA_RS31985	COG2936	dipeptidyl-peptidase activity
SMALA_RS31995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMALA_RS32005	COG2183	response to ionizing radiation
SMALA_RS32015	COG1024	Enoyl-CoA hydratase
SMALA_RS32025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SMALA_RS32075	COG1134	teichoic acid transport
SMALA_RS32090	COG1562	ergosterol biosynthetic process
SMALA_RS32100	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SMALA_RS32110	COG1657	PFAM Prenyltransferase squalene oxidase
SMALA_RS32125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMALA_RS32130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMALA_RS32145	COG2365	Tyrosine phosphatase family
SMALA_RS32150	COG2755	lipolytic protein G-D-S-L family
SMALA_RS32175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMALA_RS32225	COG0596	Alpha beta hydrolase
SMALA_RS32230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMALA_RS32235	COG0531	amino acid
SMALA_RS32250	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS32290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMALA_RS32300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMALA_RS32305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMALA_RS32310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMALA_RS32315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMALA_RS32320	COG5002	protein histidine kinase activity
SMALA_RS32325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMALA_RS32330	COG0072	phenylalanine-tRNA ligase activity
SMALA_RS32330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMALA_RS32345	COG2860	membrane
SMALA_RS32370	COG1285	pathogenesis
SMALA_RS32375	COG2814	Major facilitator Superfamily
SMALA_RS32395	COG1649	PFAM Uncharacterised BCR, COG1649
SMALA_RS32405	COG0697	spore germination
SMALA_RS32410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMALA_RS32425	COG2838	Isocitrate dehydrogenase
SMALA_RS32430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMALA_RS32435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMALA_RS32440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMALA_RS32445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMALA_RS32450	COG1438	arginine binding
SMALA_RS32455	COG0385	Bile acid
SMALA_RS32465	COG0583	DNA-binding transcription factor activity
SMALA_RS32475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMALA_RS32505	COG0137	argininosuccinate synthase activity
SMALA_RS32510	COG0165	Argininosuccinate lyase
SMALA_RS32525	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS32525	COG0204	Acyl-transferase
SMALA_RS32565	COG2011	ABC-type metal ion transport system permease component
SMALA_RS32570	COG1464	Belongs to the NlpA lipoprotein family
SMALA_RS32585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMALA_RS32590	COG1648	precorrin-2 dehydrogenase activity
SMALA_RS32590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMALA_RS32615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMALA_RS32720	COG1733	regulation of RNA biosynthetic process
SMALA_RS32735	COG3344	reverse transcriptase
SMALA_RS32775	COG0512	Glutamine amidotransferase of anthranilate synthase
SMALA_RS32775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMALA_RS32840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMALA_RS32855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMALA_RS32875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMALA_RS32885	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS32895	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SMALA_RS32900	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SMALA_RS32905	COG0217	transcriptional regulatory protein
SMALA_RS32910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMALA_RS32915	COG0632	four-way junction helicase activity
SMALA_RS32920	COG2255	four-way junction helicase activity
SMALA_RS32930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMALA_RS32935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMALA_RS32940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMALA_RS32945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMALA_RS32950	COG1196	nuclear chromosome segregation
SMALA_RS32955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMALA_RS32965	COG0124	histidyl-tRNA synthetase
SMALA_RS32970	COG2197	response regulator
SMALA_RS32975	COG4585	Histidine kinase
SMALA_RS33005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMALA_RS33020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMALA_RS33025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMALA_RS33035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMALA_RS33040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMALA_RS33045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMALA_RS33050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMALA_RS33060	COG0006	proline dipeptidase activity
SMALA_RS33065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMALA_RS33070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMALA_RS33080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMALA_RS33085	COG0540	Belongs to the ATCase OTCase family
SMALA_RS33090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMALA_RS33100	COG0505	Belongs to the CarA family
SMALA_RS33105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMALA_RS33110	COG0167	dihydroorotate dehydrogenase activity
SMALA_RS33115	COG0284	orotidine-5'-phosphate decarboxylase activity
SMALA_RS33125	COG0194	GDP metabolic process
SMALA_RS33140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMALA_RS33155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMALA_RS33160	COG1132	(ABC) transporter
SMALA_RS33175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMALA_RS33180	COG2390	Transcriptional regulator
SMALA_RS33185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMALA_RS33195	COG0640	Transcriptional regulator
SMALA_RS33230	COG0531	amino acid
SMALA_RS33240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMALA_RS33265	COG2233	PERMEase
SMALA_RS33275	COG0738	Major facilitator superfamily
SMALA_RS33280	COG1846	Transcriptional regulator
SMALA_RS33280	COG1940	carbohydrate kinase activity
SMALA_RS33300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMALA_RS33300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMALA_RS33305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMALA_RS33310	COG0140	phosphoribosyl-ATP diphosphatase activity
SMALA_RS33315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMALA_RS33360	COG5001	Diguanylate cyclase
SMALA_RS33360	COG3300	MHYT domain
SMALA_RS33370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMALA_RS33385	COG0473	3-isopropylmalate dehydrogenase activity
SMALA_RS33390	COG0066	3-isopropylmalate dehydratase activity
SMALA_RS33400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMALA_RS33420	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS33430	COG3320	Male sterility
SMALA_RS33430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS33455	COG1132	(ABC) transporter
SMALA_RS33460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS33470	COG1131	(ABC) transporter
SMALA_RS33490	COG3251	PFAM MbtH domain protein
SMALA_RS33510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS33515	COG4585	Histidine kinase
SMALA_RS33520	COG0165	Argininosuccinate lyase
SMALA_RS33530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMALA_RS33545	COG3483	tryptophan 2,3-dioxygenase activity
SMALA_RS33555	COG0475	glutathione-regulated potassium exporter activity
SMALA_RS33565	COG1051	belongs to the nudix hydrolase family
SMALA_RS33590	COG2226	methyltransferase
SMALA_RS33595	COG0667	Aldo Keto reductase
SMALA_RS33610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMALA_RS33615	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SMALA_RS33630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMALA_RS33635	COG0494	nUDIX hydrolase
SMALA_RS33640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMALA_RS33655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMALA_RS33670	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS33685	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS33710	COG0463	Glycosyl transferase, family 2
SMALA_RS33740	COG2186	Transcriptional regulator
SMALA_RS33805	COG1556	Lactate utilization protein
SMALA_RS33810	COG1139	Iron-sulfur cluster binding protein
SMALA_RS33815	COG0247	lactate metabolic process
SMALA_RS33820	COG1070	Carbohydrate kinase
SMALA_RS33825	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS33825	COG3347	Dehydrogenase
SMALA_RS33835	COG3250	beta-galactosidase activity
SMALA_RS33860	COG3254	rhamnose metabolic process
SMALA_RS33870	COG1609	Transcriptional regulator
SMALA_RS33875	COG1609	Transcriptional regulator
SMALA_RS33880	COG2072	flavoprotein involved in K transport
SMALA_RS33905	COG0596	Alpha beta hydrolase
SMALA_RS33915	COG2264	protein methyltransferase activity
SMALA_RS33925	COG4569	acetaldehyde dehydrogenase (acetylating) activity
SMALA_RS33930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMALA_RS33960	COG1175	transmembrane transport
SMALA_RS33965	COG0395	ABC-type sugar transport system, permease component
SMALA_RS33975	COG1874	Beta-galactosidase
SMALA_RS33995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS34060	COG0604	alcohol dehydrogenase
SMALA_RS34190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMALA_RS34205	COG0642	Histidine kinase
SMALA_RS34210	COG2018	Roadblock/LC7 domain
SMALA_RS34235	COG0395	ABC-type sugar transport system, permease component
SMALA_RS34240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS34250	COG0583	DNA-binding transcription factor activity
SMALA_RS34295	COG4565	transcriptional regulatory protein
SMALA_RS34300	COG3290	protein histidine kinase activity
SMALA_RS34315	COG1609	Transcriptional regulator
SMALA_RS34320	COG0395	ABC-type sugar transport system, permease component
SMALA_RS34325	COG1175	transmembrane transport
SMALA_RS34340	COG1070	Carbohydrate kinase
SMALA_RS34355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMALA_RS34365	COG1968	undecaprenyl-diphosphatase activity
SMALA_RS34370	COG2271	Major facilitator Superfamily
SMALA_RS34380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMALA_RS34450	COG1832	CoA-binding protein
SMALA_RS34460	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS34465	COG1335	isochorismatase
SMALA_RS34475	COG2267	carboxylic ester hydrolase activity
SMALA_RS34480	COG2066	Belongs to the glutaminase family
SMALA_RS34520	COG0028	Belongs to the TPP enzyme family
SMALA_RS34525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMALA_RS34570	COG2814	Major facilitator Superfamily
SMALA_RS34580	COG1739	Uncharacterized protein family UPF0029
SMALA_RS34585	COG0420	3'-5' exonuclease activity
SMALA_RS34595	COG0419	ATPase involved in DNA repair
SMALA_RS34610	COG0626	cystathionine gamma-synthase activity
SMALA_RS34640	COG2188	Transcriptional regulator
SMALA_RS34645	COG1940	carbohydrate kinase activity
SMALA_RS34655	COG0009	L-threonylcarbamoyladenylate synthase
SMALA_RS34670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMALA_RS34715	COG0577	efflux transmembrane transporter activity
SMALA_RS34715	COG1136	(ABC) transporter
SMALA_RS34720	COG2226	methyltransferase
SMALA_RS34725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMALA_RS34730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMALA_RS34735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMALA_RS34740	COG0156	8-amino-7-oxononanoate synthase activity
SMALA_RS34770	COG0741	lytic transglycosylase activity
SMALA_RS34770	COG0791	NLP P60 protein
SMALA_RS34780	COG0740	serine-type endopeptidase activity
SMALA_RS34790	COG2234	aminopeptidase activity
SMALA_RS34790	COG4935	Belongs to the peptidase S8 family
SMALA_RS34795	COG0831	urea catabolic process
SMALA_RS34800	COG0832	Belongs to the urease beta subunit family
SMALA_RS34805	COG0804	urea catabolic process
SMALA_RS34810	COG0830	nickel cation binding
SMALA_RS34815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SMALA_RS34820	COG0829	nickel cation binding
SMALA_RS34865	COG0205	6-phosphofructokinase activity
SMALA_RS34870	COG3442	glutamine amidotransferase
SMALA_RS34880	COG0242	peptide deformylase activity
SMALA_RS34890	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS34895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMALA_RS34925	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS34940	COG0702	epimerase
SMALA_RS34945	COG3631	Ketosteroid isomerase-related protein
SMALA_RS34965	COG0252	asparaginase activity
SMALA_RS34980	COG1793	dna ligase
SMALA_RS34990	COG1191	sigma factor activity
SMALA_RS35005	COG1132	(ABC) transporter
SMALA_RS35010	COG1132	(ABC) transporter
SMALA_RS35015	COG1349	DNA-binding transcription factor activity
SMALA_RS35020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMALA_RS35025	COG3395	kinase activity
SMALA_RS35030	COG0667	Aldo Keto reductase
SMALA_RS35040	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS35100	COG3903	Transcriptional regulator
SMALA_RS35100	COG3629	intracellular signal transduction
SMALA_RS35125	COG0395	ABC-type sugar transport system, permease component
SMALA_RS35130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMALA_RS35165	COG0242	peptide deformylase activity
SMALA_RS35180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMALA_RS35190	COG3250	beta-galactosidase activity
SMALA_RS35230	COG1063	alcohol dehydrogenase
SMALA_RS35255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMALA_RS35260	COG0277	FAD linked oxidase domain protein
SMALA_RS35270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMALA_RS35330	COG0640	Transcriptional regulator
SMALA_RS35350	COG1126	abc transporter atp-binding protein
SMALA_RS35355	COG0765	amino acid transport
SMALA_RS35400	COG2186	Transcriptional regulator
SMALA_RS35425	COG0514	ATP-dependent DNA helicase (RecQ)
SMALA_RS35445	COG1063	alcohol dehydrogenase
SMALA_RS35450	COG0395	ABC-type sugar transport system, permease component
SMALA_RS35460	COG1653	transport
SMALA_RS35470	COG1486	melibiose metabolic process
SMALA_RS35480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS35485	COG1653	transport
SMALA_RS35490	COG1175	transmembrane transport
SMALA_RS35495	COG0395	ABC-type sugar transport system, permease component
SMALA_RS35570	COG2353	YceI-like domain
SMALA_RS35580	COG0386	Belongs to the glutathione peroxidase family
SMALA_RS35590	COG1595	DNA-templated transcription, initiation
SMALA_RS35605	COG2197	response regulator
SMALA_RS35645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMALA_RS35655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMALA_RS35660	COG0583	DNA-binding transcription factor activity
SMALA_RS35665	COG2851	Citrate transporter
SMALA_RS35675	COG1064	alcohol dehydrogenase
SMALA_RS35680	COG3537	Alpha-1,2-mannosidase
SMALA_RS35685	COG4221	oxidoreductase activity
SMALA_RS35695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMALA_RS35705	COG0174	glutamine synthetase
SMALA_RS35710	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SMALA_RS35720	COG2133	pyrroloquinoline quinone binding
SMALA_RS35730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMALA_RS35735	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SMALA_RS35755	COG0438	transferase activity, transferring glycosyl groups
SMALA_RS35760	COG0745	RESPONSE REGULATOR receiver
SMALA_RS35790	COG0477	Major facilitator Superfamily
SMALA_RS35795	COG1733	regulation of RNA biosynthetic process
SMALA_RS35800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMALA_RS35810	COG0671	phosphoesterase, PA-phosphatase related
SMALA_RS35860	COG0110	maltose O-acetyltransferase activity
SMALA_RS35875	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SMALA_RS35945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMALA_RS36000	COG1131	(ABC) transporter
SMALA_RS36010	COG4585	Histidine kinase
SMALA_RS36015	COG2197	response regulator
SMALA_RS36025	COG0667	Aldo Keto reductase
SMALA_RS36045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMALA_RS36055	COG1252	NADH dehydrogenase
SMALA_RS36060	COG3959	Transketolase, thiamine diphosphate binding domain
SMALA_RS36075	COG3360	Dodecin
SMALA_RS36085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SMALA_RS36105	COG1024	Enoyl-CoA hydratase
SMALA_RS36110	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS36125	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS36130	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS36135	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS36145	COG0183	Belongs to the thiolase family
SMALA_RS36185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMALA_RS36200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMALA_RS36210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMALA_RS36215	COG2205	protein histidine kinase activity
SMALA_RS36220	COG0745	RESPONSE REGULATOR receiver
SMALA_RS36270	COG0191	fructose-bisphosphate aldolase activity
SMALA_RS36275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMALA_RS36280	COG1349	DNA-binding transcription factor activity
SMALA_RS36285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMALA_RS36315	COG2182	Extracellular solute-binding protein
SMALA_RS36320	COG1175	transmembrane transport
SMALA_RS36325	COG0395	ABC-type sugar transport system, permease component
SMALA_RS36330	COG2723	6-phospho-beta-galactosidase activity
SMALA_RS36355	COG1796	DNA polymerase
SMALA_RS36355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMALA_RS36365	COG3250	beta-galactosidase activity
SMALA_RS36390	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS36410	COG1802	Transcriptional regulator
SMALA_RS36415	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS36420	COG0596	Alpha beta hydrolase
SMALA_RS36435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS36440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMALA_RS36450	COG1522	sequence-specific DNA binding
SMALA_RS36480	COG0443	Heat shock 70 kDa protein
SMALA_RS36495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SMALA_RS36500	COG0477	Major facilitator Superfamily
SMALA_RS36530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMALA_RS36535	COG1834	amidinotransferase
SMALA_RS36545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS36550	COG0604	alcohol dehydrogenase
SMALA_RS36550	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS36550	COG3321	synthase
SMALA_RS36560	COG0673	inositol 2-dehydrogenase activity
SMALA_RS36570	COG3290	protein histidine kinase activity
SMALA_RS36610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS36610	COG1522	sequence-specific DNA binding
SMALA_RS36615	COG2313	pseudouridylate synthase activity
SMALA_RS36620	COG0384	phenazine biosynthesis protein PhzF
SMALA_RS36640	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS36645	COG1252	NADH dehydrogenase
SMALA_RS36650	COG1595	DNA-templated transcription, initiation
SMALA_RS36660	COG0542	response to heat
SMALA_RS36670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SMALA_RS36675	COG2936	dipeptidyl-peptidase activity
SMALA_RS36685	COG3629	intracellular signal transduction
SMALA_RS36705	COG0604	alcohol dehydrogenase
SMALA_RS36705	COG3321	synthase
SMALA_RS36710	COG3321	synthase
SMALA_RS36710	COG0604	alcohol dehydrogenase
SMALA_RS36715	COG3321	synthase
SMALA_RS36715	COG0604	alcohol dehydrogenase
SMALA_RS36795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS36890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS36895	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMALA_RS36900	COG2080	2 iron, 2 sulfur cluster binding
SMALA_RS36915	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SMALA_RS36950	COG0477	Major facilitator Superfamily
SMALA_RS36970	COG3012	SEC-C Motif Domain Protein
SMALA_RS36975	COG1063	alcohol dehydrogenase
SMALA_RS36980	COG2271	Major facilitator Superfamily
SMALA_RS36985	COG0246	Mannitol dehydrogenase
SMALA_RS37110	COG0464	growth
SMALA_RS37125	COG2197	response regulator
SMALA_RS37145	COG0437	4 iron, 4 sulfur cluster binding
SMALA_RS37150	COG3383	formate dehydrogenase (NAD+) activity
SMALA_RS37150	COG0243	molybdopterin cofactor binding
SMALA_RS37195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMALA_RS37240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMALA_RS37250	COG2340	Cysteine-rich secretory protein family
SMALA_RS37265	COG0531	amino acid
SMALA_RS37275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMALA_RS37300	COG3290	protein histidine kinase activity
SMALA_RS37330	COG1024	Enoyl-CoA hydratase
SMALA_RS37390	COG2205	protein histidine kinase activity
SMALA_RS37395	COG0745	RESPONSE REGULATOR receiver
SMALA_RS37400	COG1017	nitric oxide dioxygenase activity
SMALA_RS37400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMALA_RS37415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMALA_RS37425	COG2326	polyphosphate kinase activity
SMALA_RS37435	COG0309	Hydrogenase expression formation protein (HypE)
SMALA_RS37445	COG0298	carbon dioxide binding
SMALA_RS37450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMALA_RS37485	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS37490	COG1309	transcriptional regulator
SMALA_RS37495	COG2188	Transcriptional regulator
SMALA_RS37500	COG3573	Dehydrogenase
SMALA_RS37510	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMALA_RS37520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMALA_RS37525	COG3572	ergothioneine biosynthetic process
SMALA_RS37535	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS37540	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS37550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMALA_RS37555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMALA_RS37570	COG1940	carbohydrate kinase activity
SMALA_RS37575	COG1070	Carbohydrate kinase
SMALA_RS37585	COG4677	pectinesterase activity
SMALA_RS37595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMALA_RS37635	COG2018	Roadblock/LC7 domain
SMALA_RS37645	COG1946	Acyl-CoA thioesterase
SMALA_RS37660	COG1132	(ABC) transporter
SMALA_RS37665	COG1132	(ABC) transporter
SMALA_RS37680	COG1132	(ABC) transporter
SMALA_RS37685	COG3629	intracellular signal transduction
SMALA_RS37790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMALA_RS37825	COG3321	synthase
SMALA_RS37825	COG0604	alcohol dehydrogenase
SMALA_RS37850	COG3321	synthase
SMALA_RS37850	COG0604	alcohol dehydrogenase
SMALA_RS37855	COG3321	synthase
SMALA_RS37855	COG0604	alcohol dehydrogenase
SMALA_RS37860	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS37875	COG1733	regulation of RNA biosynthetic process
SMALA_RS37895	COG2391	methyltransferase activity
SMALA_RS37900	COG3226	Transcriptional regulator
SMALA_RS37915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMALA_RS37920	COG1113	amino acid transport
SMALA_RS37925	COG3708	Transcriptional regulator
SMALA_RS37925	COG2207	Transcriptional regulator
SMALA_RS37945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS37950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMALA_RS37955	COG2080	2 iron, 2 sulfur cluster binding
SMALA_RS37965	COG0673	inositol 2-dehydrogenase activity
SMALA_RS37970	COG0673	inositol 2-dehydrogenase activity
SMALA_RS37975	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS38005	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS38015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS38020	COG0601	transmembrane transport
SMALA_RS38025	COG4166	transmembrane transport
SMALA_RS38030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMALA_RS38055	COG0596	Alpha beta hydrolase
SMALA_RS38060	COG2188	Transcriptional regulator
SMALA_RS38065	COG1397	ADP-ribosylglycohydrolase
SMALA_RS38075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMALA_RS38085	COG4221	oxidoreductase activity
SMALA_RS38120	COG0367	asparagine synthase
SMALA_RS38135	COG0673	inositol 2-dehydrogenase activity
SMALA_RS38155	COG1280	lysine exporter protein (LysE YggA)
SMALA_RS38205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS38240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS38250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS38270	COG2423	ornithine cyclodeaminase activity
SMALA_RS38275	COG2197	response regulator
SMALA_RS38280	COG4585	Histidine kinase
SMALA_RS38285	COG0586	Pfam SNARE associated Golgi protein
SMALA_RS38300	COG0765	amino acid transport
SMALA_RS38305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMALA_RS38330	COG0667	Aldo Keto reductase
SMALA_RS38350	COG0667	Aldo Keto reductase
SMALA_RS38355	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS38360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMALA_RS38375	COG2814	Major facilitator Superfamily
SMALA_RS38390	COG0673	inositol 2-dehydrogenase activity
SMALA_RS38405	COG1796	DNA polymerase
SMALA_RS38405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMALA_RS38435	COG0697	spore germination
SMALA_RS38455	COG0574	Belongs to the PEP-utilizing enzyme family
SMALA_RS38455	COG3848	Pyruvate phosphate dikinase
SMALA_RS38460	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS38500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SMALA_RS38505	COG4585	Histidine kinase
SMALA_RS38515	COG1454	alcohol dehydrogenase
SMALA_RS38525	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS38530	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS38535	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
SMALA_RS38550	COG0477	Major facilitator Superfamily
SMALA_RS38595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SMALA_RS38600	COG1024	Enoyl-CoA hydratase
SMALA_RS38605	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS38610	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS38620	COG0583	DNA-binding transcription factor activity
SMALA_RS38630	COG1940	carbohydrate kinase activity
SMALA_RS38630	COG1846	Transcriptional regulator
SMALA_RS38635	COG3345	alpha-galactosidase
SMALA_RS38660	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMALA_RS38755	COG0531	amino acid
SMALA_RS38785	COG0154	amidase activity
SMALA_RS38790	COG2050	protein possibly involved in aromatic compounds catabolism
SMALA_RS38820	COG0745	RESPONSE REGULATOR receiver
SMALA_RS38825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMALA_RS38830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS38865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMALA_RS38880	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS38890	COG3226	Transcriptional regulator
SMALA_RS38895	COG0738	Major facilitator superfamily
SMALA_RS38915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMALA_RS38975	COG0475	glutathione-regulated potassium exporter activity
SMALA_RS38990	COG0583	DNA-binding transcription factor activity
SMALA_RS38995	COG0604	alcohol dehydrogenase
SMALA_RS38995	COG3321	synthase
SMALA_RS39020	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS39025	COG0444	Belongs to the ABC transporter superfamily
SMALA_RS39030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS39035	COG0601	transmembrane transport
SMALA_RS39070	COG2130	NADP-dependent
SMALA_RS39080	COG1309	transcriptional regulator
SMALA_RS39085	COG3424	synthase
SMALA_RS39160	COG1024	Enoyl-CoA hydratase
SMALA_RS39165	COG1024	Enoyl-CoA hydratase
SMALA_RS39195	COG4569	acetaldehyde dehydrogenase (acetylating) activity
SMALA_RS39215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMALA_RS39230	COG2175	clavaminate synthase activity
SMALA_RS39265	COG0165	Argininosuccinate lyase
SMALA_RS39275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMALA_RS39280	COG2197	response regulator
SMALA_RS39285	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS39290	COG1309	transcriptional regulator
SMALA_RS39305	COG2267	carboxylic ester hydrolase activity
SMALA_RS39315	COG4221	oxidoreductase activity
SMALA_RS39325	COG1063	alcohol dehydrogenase
SMALA_RS39330	COG0667	Aldo Keto reductase
SMALA_RS39345	COG2315	Protein conserved in bacteria
SMALA_RS39375	COG2186	Transcriptional regulator
SMALA_RS39385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMALA_RS39400	COG3842	ATPase activity
SMALA_RS39405	COG1178	ABC-type Fe3 transport system permease component
SMALA_RS39410	COG1840	ABC-type Fe3 transport system, periplasmic component
SMALA_RS39430	COG0588	phosphoglycerate mutase activity
SMALA_RS39450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMALA_RS39460	COG0698	ribose 5-phosphate isomerase
SMALA_RS39475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMALA_RS39480	COG2159	amidohydrolase
SMALA_RS39495	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SMALA_RS39500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS39505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS39510	COG1120	ATPase activity
SMALA_RS39515	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SMALA_RS39520	COG1132	(ABC) transporter
SMALA_RS39530	COG1132	(ABC) transporter
SMALA_RS39535	COG2382	esterase
SMALA_RS39570	COG1017	nitric oxide dioxygenase activity
SMALA_RS39570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMALA_RS39585	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SMALA_RS39590	COG1140	nitrate reductase beta subunit
SMALA_RS39600	COG1309	transcriptional regulator
SMALA_RS39630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMALA_RS39640	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS39655	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS39660	COG0444	Belongs to the ABC transporter superfamily
SMALA_RS39665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS39685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMALA_RS39690	COG1349	DNA-binding transcription factor activity
SMALA_RS39730	COG0154	amidase activity
SMALA_RS39735	COG1309	transcriptional regulator
SMALA_RS39740	COG0300	oxidoreductase activity
SMALA_RS39760	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS39765	COG0657	acetylesterase activity
SMALA_RS39785	COG1879	ABC-type sugar transport system periplasmic component
SMALA_RS39790	COG1063	alcohol dehydrogenase
SMALA_RS39795	COG1069	ribulokinase activity
SMALA_RS39805	COG1129	ABC transporter
SMALA_RS39810	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS39815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMALA_RS39820	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS39825	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS39840	COG2409	Drug exporters of the RND superfamily
SMALA_RS39845	COG1131	(ABC) transporter
SMALA_RS39855	COG2205	protein histidine kinase activity
SMALA_RS39870	COG2197	response regulator
SMALA_RS39875	COG4585	Histidine kinase
SMALA_RS39890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMALA_RS39895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMALA_RS39920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMALA_RS39950	COG3293	Transposase
SMALA_RS40010	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40015	COG1309	transcriptional regulator
SMALA_RS40030	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMALA_RS40035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SMALA_RS40050	COG0477	Major facilitator Superfamily
SMALA_RS40065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMALA_RS40070	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40080	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40085	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40090	COG1063	alcohol dehydrogenase
SMALA_RS40095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMALA_RS40100	COG2084	Dehydrogenase
SMALA_RS40125	COG1175	transmembrane transport
SMALA_RS40130	COG0395	ABC-type sugar transport system, permease component
SMALA_RS40135	COG2186	Transcriptional regulator
SMALA_RS40140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS40145	COG1116	anion transmembrane transporter activity
SMALA_RS40150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMALA_RS40170	COG3250	beta-galactosidase activity
SMALA_RS40180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SMALA_RS40190	COG1891	lyase activity
SMALA_RS40195	COG0456	acetyltransferase
SMALA_RS40220	COG1595	DNA-templated transcription, initiation
SMALA_RS40230	COG0300	oxidoreductase activity
SMALA_RS40245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMALA_RS40265	COG1595	DNA-templated transcription, initiation
SMALA_RS40295	COG3260	NADH ubiquinone oxidoreductase 20
SMALA_RS40305	COG0650	Formate hydrogenlyase subunit 4
SMALA_RS40315	COG0651	ATP synthesis coupled electron transport
SMALA_RS40320	COG3261	NADH dehydrogenase
SMALA_RS40320	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SMALA_RS40330	COG0477	Major facilitator Superfamily
SMALA_RS40340	COG0028	Belongs to the TPP enzyme family
SMALA_RS40345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMALA_RS40350	COG2188	Transcriptional regulator
SMALA_RS40355	COG1070	Carbohydrate kinase
SMALA_RS40380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMALA_RS40385	COG3938	Belongs to the proline racemase family
SMALA_RS40395	COG0395	ABC-type sugar transport system, permease component
SMALA_RS40400	COG1175	transmembrane transport
SMALA_RS40410	COG1609	Transcriptional regulator
SMALA_RS40420	COG1129	ABC transporter
SMALA_RS40425	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS40440	COG1228	amidohydrolase
SMALA_RS40450	COG1802	Transcriptional regulator
SMALA_RS40465	COG0583	DNA-binding transcription factor activity
SMALA_RS40490	COG5002	protein histidine kinase activity
SMALA_RS40500	COG1136	(ABC) transporter
SMALA_RS40505	COG1136	(ABC) transporter
SMALA_RS40515	COG0745	RESPONSE REGULATOR receiver
SMALA_RS40520	COG0583	DNA-binding transcription factor activity
SMALA_RS40525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMALA_RS40535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS40545	COG1116	anion transmembrane transporter activity
SMALA_RS40560	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40565	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS40570	COG4608	Belongs to the ABC transporter superfamily
SMALA_RS40580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS40585	COG0601	transmembrane transport
SMALA_RS40590	COG0747	negative chemotaxis
SMALA_RS40625	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40640	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40705	COG0402	S-adenosylhomocysteine deaminase activity
SMALA_RS40710	COG0277	FAD linked oxidase domain protein
SMALA_RS40725	COG1309	transcriptional regulator
SMALA_RS40730	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS40740	COG1914	H( )-stimulated, divalent metal cation uptake system
SMALA_RS40755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMALA_RS40770	COG1802	Transcriptional regulator
SMALA_RS40795	COG0765	amino acid transport
SMALA_RS40805	COG2186	Transcriptional regulator
SMALA_RS40830	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS40835	COG1129	ABC transporter
SMALA_RS40850	COG0434	BtpA family
SMALA_RS40855	COG1609	Transcriptional regulator
SMALA_RS40900	COG2124	cytochrome p450
SMALA_RS40930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMALA_RS40945	COG2423	ornithine cyclodeaminase activity
SMALA_RS40955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMALA_RS40960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMALA_RS40965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS40970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS40975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMALA_RS41020	COG2318	DinB family
SMALA_RS41070	COG0667	Aldo Keto reductase
SMALA_RS41090	COG2124	cytochrome p450
SMALA_RS41135	COG1175	transmembrane transport
SMALA_RS41140	COG0395	ABC-type sugar transport system, permease component
SMALA_RS41145	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SMALA_RS41150	COG5492	domain, Protein
SMALA_RS41160	COG0275	rRNA processing
SMALA_RS41165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMALA_RS41170	COG1120	ATPase activity
SMALA_RS41180	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMALA_RS41190	COG1121	(ABC) transporter
SMALA_RS41250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMALA_RS41255	COG0667	Aldo Keto reductase
SMALA_RS41260	COG2207	Transcriptional regulator
SMALA_RS41265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMALA_RS41270	COG1993	acr, cog1993
SMALA_RS41275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMALA_RS41285	COG0215	cysteine-tRNA ligase activity
SMALA_RS41325	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMALA_RS41330	COG0657	acetylesterase activity
SMALA_RS41335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMALA_RS41340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMALA_RS41420	COG2826	transposase and inactivated derivatives, IS30 family
SMALA_RS41425	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SMALA_RS41425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS41450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMALA_RS41460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS41520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMALA_RS41535	COG1414	Transcriptional regulator
SMALA_RS41550	COG4221	oxidoreductase activity
SMALA_RS41575	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS41580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS41595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMALA_RS41615	COG1129	ABC transporter
SMALA_RS41620	COG4214	carbohydrate transport
SMALA_RS41625	COG0583	DNA-binding transcription factor activity
SMALA_RS41645	COG0154	amidase activity
SMALA_RS41675	COG1653	transport
SMALA_RS41685	COG1609	Transcriptional regulator
SMALA_RS41695	COG3511	phospholipase C
SMALA_RS41700	COG3511	phospholipase C
SMALA_RS41710	COG2188	Transcriptional regulator
SMALA_RS41730	COG3842	ATPase activity
SMALA_RS41745	COG0406	alpha-ribazole phosphatase activity
SMALA_RS41745	COG0494	nUDIX hydrolase
SMALA_RS41765	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SMALA_RS41780	COG0604	alcohol dehydrogenase
SMALA_RS41800	COG1012	belongs to the aldehyde dehydrogenase family
SMALA_RS41810	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS41820	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMALA_RS41825	COG0604	alcohol dehydrogenase
SMALA_RS41835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMALA_RS41845	COG0730	response to heat
SMALA_RS41855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMALA_RS41865	COG2890	protein-(glutamine-N5) methyltransferase activity
SMALA_RS41870	COG0492	ferredoxin-NADP+ reductase activity
SMALA_RS41880	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMALA_RS41890	COG1309	transcriptional regulator
SMALA_RS41895	COG1960	acyl-CoA dehydrogenase activity
SMALA_RS41905	COG0747	negative chemotaxis
SMALA_RS41910	COG0601	transmembrane transport
SMALA_RS41915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS41955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMALA_RS41955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMALA_RS41975	COG0714	Associated with various cellular activities
SMALA_RS42000	COG0251	oxidation-reduction process
SMALA_RS42005	COG2423	ornithine cyclodeaminase activity
SMALA_RS42010	COG0604	alcohol dehydrogenase
SMALA_RS42010	COG3321	synthase
SMALA_RS42010	COG0604	alcohol dehydrogenase
SMALA_RS42010	COG3321	synthase
SMALA_RS42020	COG0604	alcohol dehydrogenase
SMALA_RS42020	COG3321	synthase
SMALA_RS42035	COG0436	Aminotransferase
SMALA_RS42040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMALA_RS42045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMALA_RS42080	COG3629	intracellular signal transduction
SMALA_RS42080	COG3903	Transcriptional regulator
SMALA_RS42085	COG0367	asparagine synthase
SMALA_RS42100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMALA_RS42120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMALA_RS42130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMALA_RS42155	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS42160	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SMALA_RS42185	COG0596	Alpha beta hydrolase
SMALA_RS42200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMALA_RS42210	COG1902	pentaerythritol trinitrate reductase activity
SMALA_RS42240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMALA_RS42260	COG0066	3-isopropylmalate dehydratase activity
SMALA_RS42265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMALA_RS42275	COG1028	Short-chain dehydrogenase reductase Sdr
SMALA_RS42280	COG4948	Mandelate Racemase Muconate Lactonizing
SMALA_RS42340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMALA_RS42345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMALA_RS42350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMALA_RS42355	COG2080	2 iron, 2 sulfur cluster binding
SMALA_RS42365	COG0300	oxidoreductase activity
SMALA_RS42385	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SMALA_RS42400	COG1309	transcriptional regulator
SMALA_RS42480	COG1733	regulation of RNA biosynthetic process
SMALA_RS42485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMALA_RS42515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS42520	COG0778	Nitroreductase
SMALA_RS42535	COG0667	Aldo Keto reductase
SMALA_RS42540	COG0667	Aldo Keto reductase
SMALA_RS42545	COG2271	Major facilitator Superfamily
SMALA_RS42555	COG0747	negative chemotaxis
SMALA_RS42560	COG0601	transmembrane transport
SMALA_RS42565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMALA_RS42590	COG2755	lipolytic protein G-D-S-L family
SMALA_RS42650	COG1309	transcriptional regulator
SMALA_RS42655	COG0346	lactoylglutathione lyase activity
SMALA_RS42665	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SMALA_RS42670	COG2146	nitrite reductase [NAD(P)H] activity
SMALA_RS42680	COG2267	carboxylic ester hydrolase activity
SMALA_RS42690	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMALA_RS42700	COG0477	Major facilitator Superfamily
SMALA_RS42710	COG1178	ABC-type Fe3 transport system permease component
SMALA_RS42715	COG1840	ABC-type Fe3 transport system, periplasmic component
SMALA_RS42735	COG0667	Aldo Keto reductase
SMALA_RS42755	COG0436	Aminotransferase
SMALA_RS42835	COG0142	geranyltranstransferase activity
SMALA_RS42850	COG3848	Pyruvate phosphate dikinase
SMALA_RS42850	COG0574	Belongs to the PEP-utilizing enzyme family
SMALA_RS42860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMALA_RS42865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMALA_RS42865	COG0473	3-isopropylmalate dehydrogenase activity
SMALA_RS42895	COG4977	sequence-specific DNA binding
SMALA_RS42915	COG3321	synthase
SMALA_RS42915	COG0604	alcohol dehydrogenase
SMALA_RS42925	COG0318	PFAM AMP-dependent synthetase and ligase
SMALA_RS43110	COG1056	cytidyltransferase-related domain
SMALA_RS43110	COG1051	belongs to the nudix hydrolase family
SMALA_RS43200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMALA_RS43275	COG1660	Displays ATPase and GTPase activities
SMALA_RS43310	COG0741	lytic transglycosylase activity
SMALA_RS43310	COG0739	heme binding
SMALA_RS43310	COG1196	nuclear chromosome segregation