locus-tag	class	description
DNK48_RS00160	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS00175	COG0604	alcohol dehydrogenase
DNK48_RS00175	COG3321	synthase
DNK48_RS00195	COG4977	sequence-specific DNA binding
DNK48_RS00225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DNK48_RS00225	COG0473	3-isopropylmalate dehydrogenase activity
DNK48_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS00240	COG0574	Belongs to the PEP-utilizing enzyme family
DNK48_RS00240	COG3848	Pyruvate phosphate dikinase
DNK48_RS00255	COG0142	geranyltranstransferase activity
DNK48_RS00340	COG0436	Aminotransferase
DNK48_RS00360	COG0667	Aldo Keto reductase
DNK48_RS00380	COG1840	ABC-type Fe3 transport system, periplasmic component
DNK48_RS00385	COG1178	ABC-type Fe3 transport system permease component
DNK48_RS00395	COG0477	Major facilitator Superfamily
DNK48_RS00405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DNK48_RS00425	COG2267	carboxylic ester hydrolase activity
DNK48_RS00435	COG2146	nitrite reductase [NAD(P)H] activity
DNK48_RS00440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DNK48_RS00450	COG0346	lactoylglutathione lyase activity
DNK48_RS00455	COG1309	transcriptional regulator
DNK48_RS00520	COG2755	lipolytic protein G-D-S-L family
DNK48_RS00545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS00550	COG0601	transmembrane transport
DNK48_RS00555	COG0747	negative chemotaxis
DNK48_RS00565	COG2271	Major facilitator Superfamily
DNK48_RS00570	COG0667	Aldo Keto reductase
DNK48_RS00575	COG0667	Aldo Keto reductase
DNK48_RS00590	COG0778	Nitroreductase
DNK48_RS00595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS00625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DNK48_RS00630	COG1733	regulation of RNA biosynthetic process
DNK48_RS00710	COG1309	transcriptional regulator
DNK48_RS00730	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DNK48_RS00745	COG0300	oxidoreductase activity
DNK48_RS00755	COG2080	2 iron, 2 sulfur cluster binding
DNK48_RS00760	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DNK48_RS00765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS00770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNK48_RS00830	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS00835	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS00845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DNK48_RS00850	COG0066	3-isopropylmalate dehydratase activity
DNK48_RS00870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNK48_RS00895	COG1902	pentaerythritol trinitrate reductase activity
DNK48_RS00905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNK48_RS00920	COG0596	Alpha beta hydrolase
DNK48_RS00945	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DNK48_RS00950	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS00975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DNK48_RS00985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNK48_RS01005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNK48_RS01020	COG0367	asparagine synthase
DNK48_RS01025	COG3903	Transcriptional regulator
DNK48_RS01025	COG3629	intracellular signal transduction
DNK48_RS01060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DNK48_RS01065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DNK48_RS01070	COG0436	Aminotransferase
DNK48_RS01085	COG0604	alcohol dehydrogenase
DNK48_RS01085	COG3321	synthase
DNK48_RS01145	COG2423	ornithine cyclodeaminase activity
DNK48_RS01150	COG0251	oxidation-reduction process
DNK48_RS01175	COG0714	Associated with various cellular activities
DNK48_RS01195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNK48_RS01195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DNK48_RS01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS01240	COG0601	transmembrane transport
DNK48_RS01245	COG0747	negative chemotaxis
DNK48_RS01250	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS01255	COG1309	transcriptional regulator
DNK48_RS01265	COG2249	NAD(P)H dehydrogenase (quinone) activity
DNK48_RS01270	COG0154	amidase activity
DNK48_RS01275	COG0492	ferredoxin-NADP+ reductase activity
DNK48_RS01280	COG2890	protein-(glutamine-N5) methyltransferase activity
DNK48_RS01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DNK48_RS01300	COG0730	response to heat
DNK48_RS01310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS01320	COG0604	alcohol dehydrogenase
DNK48_RS01325	COG0179	Fumarylacetoacetate (FAA) hydrolase
DNK48_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS01345	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS01365	COG0604	alcohol dehydrogenase
DNK48_RS01380	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DNK48_RS01400	COG0406	alpha-ribazole phosphatase activity
DNK48_RS01400	COG0494	nUDIX hydrolase
DNK48_RS01415	COG3842	ATPase activity
DNK48_RS01435	COG2188	Transcriptional regulator
DNK48_RS01445	COG3511	phospholipase C
DNK48_RS01450	COG3511	phospholipase C
DNK48_RS01460	COG1609	Transcriptional regulator
DNK48_RS01470	COG1653	transport
DNK48_RS01500	COG0154	amidase activity
DNK48_RS01520	COG0583	DNA-binding transcription factor activity
DNK48_RS01525	COG4214	carbohydrate transport
DNK48_RS01530	COG1129	ABC transporter
DNK48_RS01555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS01570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS01575	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS01600	COG4221	oxidoreductase activity
DNK48_RS01615	COG1414	Transcriptional regulator
DNK48_RS01630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNK48_RS01690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS01700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DNK48_RS01725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS01725	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DNK48_RS01730	COG2826	transposase and inactivated derivatives, IS30 family
DNK48_RS01810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DNK48_RS01815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNK48_RS01820	COG0657	acetylesterase activity
DNK48_RS01825	COG1172	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS01865	COG0215	cysteine-tRNA ligase activity
DNK48_RS01875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNK48_RS01880	COG1993	acr, cog1993
DNK48_RS01885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNK48_RS01890	COG2207	Transcriptional regulator
DNK48_RS01895	COG0667	Aldo Keto reductase
DNK48_RS01900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DNK48_RS01960	COG1121	(ABC) transporter
DNK48_RS01970	COG0803	Belongs to the bacterial solute-binding protein 9 family
DNK48_RS01980	COG1120	ATPase activity
DNK48_RS01985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS01990	COG0275	rRNA processing
DNK48_RS02000	COG5492	domain, Protein
DNK48_RS02005	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
DNK48_RS02010	COG0395	ABC-type sugar transport system, permease component
DNK48_RS02015	COG1175	transmembrane transport
DNK48_RS02060	COG2124	cytochrome p450
DNK48_RS02080	COG0667	Aldo Keto reductase
DNK48_RS02130	COG2318	DinB family
DNK48_RS02175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS02180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS02185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS02190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNK48_RS02195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNK48_RS02205	COG2423	ornithine cyclodeaminase activity
DNK48_RS02220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS02250	COG2124	cytochrome p450
DNK48_RS02295	COG1609	Transcriptional regulator
DNK48_RS02300	COG0434	BtpA family
DNK48_RS02315	COG1129	ABC transporter
DNK48_RS02320	COG1172	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS02345	COG2186	Transcriptional regulator
DNK48_RS02355	COG0765	amino acid transport
DNK48_RS02380	COG1802	Transcriptional regulator
DNK48_RS02395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS02410	COG1914	H( )-stimulated, divalent metal cation uptake system
DNK48_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS02425	COG1309	transcriptional regulator
DNK48_RS02440	COG0277	FAD linked oxidase domain protein
DNK48_RS02445	COG0402	S-adenosylhomocysteine deaminase activity
DNK48_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS02565	COG0747	negative chemotaxis
DNK48_RS02570	COG0601	transmembrane transport
DNK48_RS02575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS02585	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS02590	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS02610	COG1116	anion transmembrane transporter activity
DNK48_RS02620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS02630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNK48_RS02635	COG0583	DNA-binding transcription factor activity
DNK48_RS02640	COG0745	RESPONSE REGULATOR receiver
DNK48_RS02650	COG1136	(ABC) transporter
DNK48_RS02655	COG1136	(ABC) transporter
DNK48_RS02665	COG5002	protein histidine kinase activity
DNK48_RS02690	COG0583	DNA-binding transcription factor activity
DNK48_RS02705	COG1802	Transcriptional regulator
DNK48_RS02715	COG1228	amidohydrolase
DNK48_RS02730	COG1172	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS02735	COG1129	ABC transporter
DNK48_RS02745	COG1609	Transcriptional regulator
DNK48_RS02755	COG1175	transmembrane transport
DNK48_RS02760	COG0395	ABC-type sugar transport system, permease component
DNK48_RS02770	COG3938	Belongs to the proline racemase family
DNK48_RS02775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNK48_RS02800	COG1070	Carbohydrate kinase
DNK48_RS02805	COG2188	Transcriptional regulator
DNK48_RS02810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DNK48_RS02815	COG0028	Belongs to the TPP enzyme family
DNK48_RS02825	COG0477	Major facilitator Superfamily
DNK48_RS02835	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DNK48_RS02835	COG3261	NADH dehydrogenase
DNK48_RS02840	COG0651	ATP synthesis coupled electron transport
DNK48_RS02850	COG0650	Formate hydrogenlyase subunit 4
DNK48_RS02860	COG3260	NADH ubiquinone oxidoreductase 20
DNK48_RS02890	COG1595	DNA-templated transcription, initiation
DNK48_RS02910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNK48_RS02925	COG0300	oxidoreductase activity
DNK48_RS02935	COG1595	DNA-templated transcription, initiation
DNK48_RS02960	COG0456	acetyltransferase
DNK48_RS02965	COG1891	lyase activity
DNK48_RS02975	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DNK48_RS02985	COG3250	beta-galactosidase activity
DNK48_RS03005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DNK48_RS03015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS03020	COG2186	Transcriptional regulator
DNK48_RS03025	COG0395	ABC-type sugar transport system, permease component
DNK48_RS03030	COG1175	transmembrane transport
DNK48_RS03055	COG2084	Dehydrogenase
DNK48_RS03060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DNK48_RS03065	COG1063	alcohol dehydrogenase
DNK48_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS03075	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS03085	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS03090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNK48_RS03105	COG0477	Major facilitator Superfamily
DNK48_RS03120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DNK48_RS03125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DNK48_RS03140	COG1309	transcriptional regulator
DNK48_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS03205	COG3293	Transposase
DNK48_RS03230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DNK48_RS03255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DNK48_RS03260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DNK48_RS03275	COG4585	Histidine kinase
DNK48_RS03280	COG2197	response regulator
DNK48_RS03300	COG2205	protein histidine kinase activity
DNK48_RS03310	COG1131	(ABC) transporter
DNK48_RS03315	COG2409	Drug exporters of the RND superfamily
DNK48_RS03330	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS03335	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS03340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DNK48_RS03345	COG1172	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS03350	COG1129	ABC transporter
DNK48_RS03360	COG1069	ribulokinase activity
DNK48_RS03365	COG1063	alcohol dehydrogenase
DNK48_RS03370	COG1879	ABC-type sugar transport system periplasmic component
DNK48_RS03390	COG0657	acetylesterase activity
DNK48_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS03415	COG0300	oxidoreductase activity
DNK48_RS03420	COG1309	transcriptional regulator
DNK48_RS03425	COG0154	amidase activity
DNK48_RS03465	COG1349	DNA-binding transcription factor activity
DNK48_RS03470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DNK48_RS03490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS03495	COG0444	Belongs to the ABC transporter superfamily
DNK48_RS03500	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS03515	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS03525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DNK48_RS03555	COG1309	transcriptional regulator
DNK48_RS03565	COG1140	nitrate reductase beta subunit
DNK48_RS03570	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DNK48_RS03585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DNK48_RS03585	COG1017	nitric oxide dioxygenase activity
DNK48_RS03620	COG2382	esterase
DNK48_RS03625	COG1132	(ABC) transporter
DNK48_RS03635	COG1132	(ABC) transporter
DNK48_RS03640	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DNK48_RS03645	COG1120	ATPase activity
DNK48_RS03650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS03655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS03660	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DNK48_RS03675	COG2159	amidohydrolase
DNK48_RS03680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DNK48_RS03695	COG0698	ribose 5-phosphate isomerase
DNK48_RS03705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DNK48_RS03725	COG0588	phosphoglycerate mutase activity
DNK48_RS03745	COG1840	ABC-type Fe3 transport system, periplasmic component
DNK48_RS03750	COG1178	ABC-type Fe3 transport system permease component
DNK48_RS03755	COG3842	ATPase activity
DNK48_RS03770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DNK48_RS03780	COG2186	Transcriptional regulator
DNK48_RS03810	COG2315	Protein conserved in bacteria
DNK48_RS03825	COG0667	Aldo Keto reductase
DNK48_RS03830	COG1063	alcohol dehydrogenase
DNK48_RS03840	COG4221	oxidoreductase activity
DNK48_RS03850	COG2267	carboxylic ester hydrolase activity
DNK48_RS03865	COG1309	transcriptional regulator
DNK48_RS03870	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS03875	COG2197	response regulator
DNK48_RS03880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DNK48_RS03890	COG0165	Argininosuccinate lyase
DNK48_RS03925	COG2175	clavaminate synthase activity
DNK48_RS03940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS03960	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DNK48_RS03985	COG1024	Enoyl-CoA hydratase
DNK48_RS03990	COG1024	Enoyl-CoA hydratase
DNK48_RS04030	COG3321	synthase
DNK48_RS04030	COG0604	alcohol dehydrogenase
DNK48_RS04075	COG3424	synthase
DNK48_RS04080	COG1309	transcriptional regulator
DNK48_RS04090	COG2130	NADP-dependent
DNK48_RS04125	COG0601	transmembrane transport
DNK48_RS04135	COG0444	Belongs to the ABC transporter superfamily
DNK48_RS04140	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS04165	COG3321	synthase
DNK48_RS04165	COG0604	alcohol dehydrogenase
DNK48_RS04170	COG0583	DNA-binding transcription factor activity
DNK48_RS04185	COG0475	glutathione-regulated potassium exporter activity
DNK48_RS04240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNK48_RS04260	COG0738	Major facilitator superfamily
DNK48_RS04265	COG3226	Transcriptional regulator
DNK48_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS04290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNK48_RS04325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS04330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DNK48_RS04335	COG0745	RESPONSE REGULATOR receiver
DNK48_RS04365	COG2050	protein possibly involved in aromatic compounds catabolism
DNK48_RS04370	COG0154	amidase activity
DNK48_RS04400	COG0531	amino acid
DNK48_RS04495	COG1176	ABC-type spermidine putrescine transport system, permease component I
DNK48_RS04520	COG3345	alpha-galactosidase
DNK48_RS04525	COG1846	Transcriptional regulator
DNK48_RS04525	COG1940	carbohydrate kinase activity
DNK48_RS04535	COG0583	DNA-binding transcription factor activity
DNK48_RS04545	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS04555	COG1024	Enoyl-CoA hydratase
DNK48_RS04560	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DNK48_RS04605	COG0477	Major facilitator Superfamily
DNK48_RS04620	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
DNK48_RS04625	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS04630	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS04640	COG1454	alcohol dehydrogenase
DNK48_RS04650	COG4585	Histidine kinase
DNK48_RS04655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DNK48_RS04695	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS04700	COG0574	Belongs to the PEP-utilizing enzyme family
DNK48_RS04700	COG3848	Pyruvate phosphate dikinase
DNK48_RS04720	COG0697	spore germination
DNK48_RS04750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DNK48_RS04750	COG1796	DNA polymerase
DNK48_RS04765	COG0673	inositol 2-dehydrogenase activity
DNK48_RS04780	COG2814	Major facilitator Superfamily
DNK48_RS04795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DNK48_RS04800	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS04805	COG0667	Aldo Keto reductase
DNK48_RS04825	COG0667	Aldo Keto reductase
DNK48_RS04855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNK48_RS04860	COG0765	amino acid transport
DNK48_RS04875	COG0586	Pfam SNARE associated Golgi protein
DNK48_RS04880	COG4585	Histidine kinase
DNK48_RS04885	COG2197	response regulator
DNK48_RS04890	COG2423	ornithine cyclodeaminase activity
DNK48_RS04910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS04915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS04920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS04925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS04960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS05010	COG1280	lysine exporter protein (LysE YggA)
DNK48_RS05030	COG0673	inositol 2-dehydrogenase activity
DNK48_RS05045	COG0367	asparagine synthase
DNK48_RS05080	COG4221	oxidoreductase activity
DNK48_RS05090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNK48_RS05100	COG1397	ADP-ribosylglycohydrolase
DNK48_RS05105	COG2188	Transcriptional regulator
DNK48_RS05110	COG0596	Alpha beta hydrolase
DNK48_RS05135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNK48_RS05145	COG4166	transmembrane transport
DNK48_RS05150	COG0601	transmembrane transport
DNK48_RS05155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS05165	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS05195	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS05200	COG0673	inositol 2-dehydrogenase activity
DNK48_RS05205	COG0673	inositol 2-dehydrogenase activity
DNK48_RS05215	COG2080	2 iron, 2 sulfur cluster binding
DNK48_RS05220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DNK48_RS05225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS05245	COG2207	Transcriptional regulator
DNK48_RS05245	COG3708	Transcriptional regulator
DNK48_RS05250	COG1113	amino acid transport
DNK48_RS05255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DNK48_RS05270	COG3226	Transcriptional regulator
DNK48_RS05275	COG2391	methyltransferase activity
DNK48_RS05295	COG1733	regulation of RNA biosynthetic process
DNK48_RS05310	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS05315	COG3321	synthase
DNK48_RS05315	COG0604	alcohol dehydrogenase
DNK48_RS05350	COG3321	synthase
DNK48_RS05350	COG0604	alcohol dehydrogenase
DNK48_RS05495	COG3629	intracellular signal transduction
DNK48_RS05500	COG1132	(ABC) transporter
DNK48_RS05515	COG1132	(ABC) transporter
DNK48_RS05520	COG1132	(ABC) transporter
DNK48_RS05535	COG1946	Acyl-CoA thioesterase
DNK48_RS05545	COG2018	Roadblock/LC7 domain
DNK48_RS05585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DNK48_RS05595	COG4677	pectinesterase activity
DNK48_RS05605	COG1070	Carbohydrate kinase
DNK48_RS05610	COG1940	carbohydrate kinase activity
DNK48_RS05625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNK48_RS05630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNK48_RS05640	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS05645	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS05660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DNK48_RS05670	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DNK48_RS05680	COG3573	Dehydrogenase
DNK48_RS05685	COG2188	Transcriptional regulator
DNK48_RS05690	COG1309	transcriptional regulator
DNK48_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS05730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DNK48_RS05735	COG0298	carbon dioxide binding
DNK48_RS05745	COG0309	Hydrogenase expression formation protein (HypE)
DNK48_RS05755	COG2326	polyphosphate kinase activity
DNK48_RS05765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DNK48_RS05780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DNK48_RS05780	COG1017	nitric oxide dioxygenase activity
DNK48_RS05785	COG0745	RESPONSE REGULATOR receiver
DNK48_RS05790	COG2205	protein histidine kinase activity
DNK48_RS05850	COG1024	Enoyl-CoA hydratase
DNK48_RS05880	COG3290	protein histidine kinase activity
DNK48_RS05905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNK48_RS05915	COG0531	amino acid
DNK48_RS05930	COG2340	Cysteine-rich secretory protein family
DNK48_RS05940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DNK48_RS05985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNK48_RS06030	COG3383	formate dehydrogenase (NAD+) activity
DNK48_RS06030	COG0243	molybdopterin cofactor binding
DNK48_RS06035	COG0437	4 iron, 4 sulfur cluster binding
DNK48_RS06055	COG2197	response regulator
DNK48_RS06070	COG0464	growth
DNK48_RS06190	COG0246	Mannitol dehydrogenase
DNK48_RS06195	COG2271	Major facilitator Superfamily
DNK48_RS06200	COG1063	alcohol dehydrogenase
DNK48_RS06205	COG3012	SEC-C Motif Domain Protein
DNK48_RS06225	COG0477	Major facilitator Superfamily
DNK48_RS06265	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DNK48_RS06280	COG2080	2 iron, 2 sulfur cluster binding
DNK48_RS06290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS06385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS06475	COG0604	alcohol dehydrogenase
DNK48_RS06475	COG3321	synthase
DNK48_RS06480	COG3321	synthase
DNK48_RS06480	COG0604	alcohol dehydrogenase
DNK48_RS06500	COG3629	intracellular signal transduction
DNK48_RS06510	COG2936	dipeptidyl-peptidase activity
DNK48_RS06515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DNK48_RS06525	COG0542	response to heat
DNK48_RS06535	COG1595	DNA-templated transcription, initiation
DNK48_RS06540	COG1252	NADH dehydrogenase
DNK48_RS06545	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS06575	COG0384	phenazine biosynthesis protein PhzF
DNK48_RS06580	COG2313	pseudouridylate synthase activity
DNK48_RS06585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNK48_RS06585	COG1522	sequence-specific DNA binding
DNK48_RS06625	COG3290	protein histidine kinase activity
DNK48_RS06635	COG0673	inositol 2-dehydrogenase activity
DNK48_RS06650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS06660	COG1834	amidinotransferase
DNK48_RS06665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DNK48_RS06695	COG0477	Major facilitator Superfamily
DNK48_RS06700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DNK48_RS06715	COG0443	Heat shock 70 kDa protein
DNK48_RS06745	COG1522	sequence-specific DNA binding
DNK48_RS06755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNK48_RS06760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS06775	COG0596	Alpha beta hydrolase
DNK48_RS06780	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS06785	COG1802	Transcriptional regulator
DNK48_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS06830	COG3250	beta-galactosidase activity
DNK48_RS06840	COG1796	DNA polymerase
DNK48_RS06840	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DNK48_RS06865	COG2723	6-phospho-beta-galactosidase activity
DNK48_RS06870	COG0395	ABC-type sugar transport system, permease component
DNK48_RS06875	COG1175	transmembrane transport
DNK48_RS06880	COG2182	Extracellular solute-binding protein
DNK48_RS06910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DNK48_RS06915	COG1349	DNA-binding transcription factor activity
DNK48_RS06920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DNK48_RS06925	COG0191	fructose-bisphosphate aldolase activity
DNK48_RS06975	COG0745	RESPONSE REGULATOR receiver
DNK48_RS06980	COG2205	protein histidine kinase activity
DNK48_RS06985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNK48_RS06995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DNK48_RS07010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNK48_RS07050	COG0183	Belongs to the thiolase family
DNK48_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS07065	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS07085	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS07090	COG1024	Enoyl-CoA hydratase
DNK48_RS07115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DNK48_RS07125	COG3360	Dodecin
DNK48_RS07140	COG3959	Transketolase, thiamine diphosphate binding domain
DNK48_RS07145	COG1252	NADH dehydrogenase
DNK48_RS07155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNK48_RS07175	COG0667	Aldo Keto reductase
DNK48_RS07185	COG2197	response regulator
DNK48_RS07190	COG4585	Histidine kinase
DNK48_RS07200	COG1131	(ABC) transporter
DNK48_RS07270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DNK48_RS07340	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DNK48_RS07355	COG0110	maltose O-acetyltransferase activity
DNK48_RS07405	COG0671	phosphoesterase, PA-phosphatase related
DNK48_RS07415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DNK48_RS07420	COG1733	regulation of RNA biosynthetic process
DNK48_RS07425	COG0477	Major facilitator Superfamily
DNK48_RS07455	COG0745	RESPONSE REGULATOR receiver
DNK48_RS07480	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DNK48_RS07495	COG2133	pyrroloquinoline quinone binding
DNK48_RS07505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DNK48_RS07510	COG0174	glutamine synthetase
DNK48_RS07520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DNK48_RS07530	COG4221	oxidoreductase activity
DNK48_RS07535	COG3537	Alpha-1,2-mannosidase
DNK48_RS07540	COG1064	alcohol dehydrogenase
DNK48_RS07550	COG2851	Citrate transporter
DNK48_RS07555	COG0583	DNA-binding transcription factor activity
DNK48_RS07560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DNK48_RS07570	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DNK48_RS07610	COG2197	response regulator
DNK48_RS07625	COG1595	DNA-templated transcription, initiation
DNK48_RS07635	COG0386	Belongs to the glutathione peroxidase family
DNK48_RS07645	COG2353	YceI-like domain
DNK48_RS07720	COG0395	ABC-type sugar transport system, permease component
DNK48_RS07725	COG1175	transmembrane transport
DNK48_RS07730	COG1653	transport
DNK48_RS07745	COG1486	melibiose metabolic process
DNK48_RS07755	COG1653	transport
DNK48_RS07765	COG0395	ABC-type sugar transport system, permease component
DNK48_RS07770	COG1063	alcohol dehydrogenase
DNK48_RS07790	COG0514	ATP-dependent DNA helicase (RecQ)
DNK48_RS07815	COG2186	Transcriptional regulator
DNK48_RS07860	COG0765	amino acid transport
DNK48_RS07865	COG1126	abc transporter atp-binding protein
DNK48_RS07885	COG0640	Transcriptional regulator
DNK48_RS07945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNK48_RS07955	COG0277	FAD linked oxidase domain protein
DNK48_RS07960	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DNK48_RS07985	COG1063	alcohol dehydrogenase
DNK48_RS08035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DNK48_RS08050	COG0242	peptide deformylase activity
DNK48_RS08085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNK48_RS08090	COG0395	ABC-type sugar transport system, permease component
DNK48_RS08115	COG3629	intracellular signal transduction
DNK48_RS08115	COG3903	Transcriptional regulator
DNK48_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS08185	COG0667	Aldo Keto reductase
DNK48_RS08190	COG3395	kinase activity
DNK48_RS08195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DNK48_RS08200	COG1349	DNA-binding transcription factor activity
DNK48_RS08210	COG1132	(ABC) transporter
DNK48_RS08225	COG1191	sigma factor activity
DNK48_RS08235	COG1793	dna ligase
DNK48_RS08250	COG0252	asparaginase activity
DNK48_RS08270	COG3631	Ketosteroid isomerase-related protein
DNK48_RS08275	COG0702	epimerase
DNK48_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS08320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DNK48_RS08325	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS08335	COG0242	peptide deformylase activity
DNK48_RS08345	COG3442	glutamine amidotransferase
DNK48_RS08350	COG0205	6-phosphofructokinase activity
DNK48_RS08395	COG0829	nickel cation binding
DNK48_RS08400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DNK48_RS08405	COG0830	nickel cation binding
DNK48_RS08410	COG0804	urea catabolic process
DNK48_RS08415	COG0832	Belongs to the urease beta subunit family
DNK48_RS08420	COG0831	urea catabolic process
DNK48_RS08425	COG4935	Belongs to the peptidase S8 family
DNK48_RS08425	COG2234	aminopeptidase activity
DNK48_RS08435	COG0740	serine-type endopeptidase activity
DNK48_RS08445	COG0741	lytic transglycosylase activity
DNK48_RS08445	COG0791	NLP P60 protein
DNK48_RS08475	COG0156	8-amino-7-oxononanoate synthase activity
DNK48_RS08480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DNK48_RS08485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DNK48_RS08490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DNK48_RS08495	COG2226	methyltransferase
DNK48_RS08500	COG0577	efflux transmembrane transporter activity
DNK48_RS08500	COG1136	(ABC) transporter
DNK48_RS08545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DNK48_RS08560	COG0009	L-threonylcarbamoyladenylate synthase
DNK48_RS08570	COG1940	carbohydrate kinase activity
DNK48_RS08575	COG2188	Transcriptional regulator
DNK48_RS08605	COG0626	cystathionine gamma-synthase activity
DNK48_RS08630	COG0420	3'-5' exonuclease activity
DNK48_RS08635	COG1739	Uncharacterized protein family UPF0029
DNK48_RS08645	COG2814	Major facilitator Superfamily
DNK48_RS08690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNK48_RS08695	COG0028	Belongs to the TPP enzyme family
DNK48_RS08735	COG2066	Belongs to the glutaminase family
DNK48_RS08740	COG2267	carboxylic ester hydrolase activity
DNK48_RS08750	COG1335	isochorismatase
DNK48_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS08765	COG1832	CoA-binding protein
DNK48_RS08835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DNK48_RS08845	COG2271	Major facilitator Superfamily
DNK48_RS08850	COG1968	undecaprenyl-diphosphatase activity
DNK48_RS08860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNK48_RS08875	COG1070	Carbohydrate kinase
DNK48_RS08890	COG1175	transmembrane transport
DNK48_RS08895	COG0395	ABC-type sugar transport system, permease component
DNK48_RS08920	COG3290	protein histidine kinase activity
DNK48_RS08925	COG4565	transcriptional regulatory protein
DNK48_RS08970	COG0583	DNA-binding transcription factor activity
DNK48_RS08980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNK48_RS08985	COG0395	ABC-type sugar transport system, permease component
DNK48_RS09010	COG2018	Roadblock/LC7 domain
DNK48_RS09015	COG0642	Histidine kinase
DNK48_RS09030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNK48_RS09160	COG0604	alcohol dehydrogenase
DNK48_RS09225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS09245	COG1874	Beta-galactosidase
DNK48_RS09255	COG0395	ABC-type sugar transport system, permease component
DNK48_RS09260	COG1175	transmembrane transport
DNK48_RS09290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DNK48_RS09295	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DNK48_RS09305	COG2264	protein methyltransferase activity
DNK48_RS09315	COG0596	Alpha beta hydrolase
DNK48_RS09340	COG2072	flavoprotein involved in K transport
DNK48_RS09345	COG1609	Transcriptional regulator
DNK48_RS09360	COG3254	rhamnose metabolic process
DNK48_RS09380	COG1129	ABC transporter
DNK48_RS09385	COG3250	beta-galactosidase activity
DNK48_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS09395	COG3347	Dehydrogenase
DNK48_RS09400	COG1070	Carbohydrate kinase
DNK48_RS09405	COG0247	lactate metabolic process
DNK48_RS09410	COG1139	Iron-sulfur cluster binding protein
DNK48_RS09415	COG1556	Lactate utilization protein
DNK48_RS09480	COG2186	Transcriptional regulator
DNK48_RS09515	COG0463	Glycosyl transferase, family 2
DNK48_RS09540	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS09555	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS09570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DNK48_RS09585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DNK48_RS09590	COG0494	nUDIX hydrolase
DNK48_RS09595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DNK48_RS09610	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DNK48_RS09615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DNK48_RS09630	COG0667	Aldo Keto reductase
DNK48_RS09635	COG2226	methyltransferase
DNK48_RS09660	COG1051	belongs to the nudix hydrolase family
DNK48_RS09670	COG0475	glutathione-regulated potassium exporter activity
DNK48_RS09680	COG3483	tryptophan 2,3-dioxygenase activity
DNK48_RS09695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DNK48_RS09705	COG0165	Argininosuccinate lyase
DNK48_RS09710	COG4585	Histidine kinase
DNK48_RS09715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS09725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS09730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS09740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS09745	COG3251	PFAM MbtH domain protein
DNK48_RS09765	COG1131	(ABC) transporter
DNK48_RS09775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS09780	COG1132	(ABC) transporter
DNK48_RS09805	COG3320	Male sterility
DNK48_RS09805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS09815	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS09835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DNK48_RS09845	COG0066	3-isopropylmalate dehydratase activity
DNK48_RS09850	COG0473	3-isopropylmalate dehydrogenase activity
DNK48_RS09865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNK48_RS09875	COG5001	Diguanylate cyclase
DNK48_RS09875	COG3300	MHYT domain
DNK48_RS09920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DNK48_RS09925	COG0140	phosphoribosyl-ATP diphosphatase activity
DNK48_RS09930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DNK48_RS09935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNK48_RS09935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNK48_RS09955	COG1846	Transcriptional regulator
DNK48_RS09955	COG1940	carbohydrate kinase activity
DNK48_RS09960	COG0738	Major facilitator superfamily
DNK48_RS09970	COG2233	PERMEase
DNK48_RS09995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DNK48_RS10010	COG0531	amino acid
DNK48_RS10045	COG0640	Transcriptional regulator
DNK48_RS10055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DNK48_RS10060	COG2390	Transcriptional regulator
DNK48_RS10065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DNK48_RS10080	COG1132	(ABC) transporter
DNK48_RS10085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DNK48_RS10100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DNK48_RS10120	COG0194	GDP metabolic process
DNK48_RS10130	COG0284	orotidine-5'-phosphate decarboxylase activity
DNK48_RS10135	COG0167	dihydroorotate dehydrogenase activity
DNK48_RS10140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DNK48_RS10145	COG0505	Belongs to the CarA family
DNK48_RS10155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DNK48_RS10160	COG0540	Belongs to the ATCase OTCase family
DNK48_RS10165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DNK48_RS10175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DNK48_RS10180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DNK48_RS10185	COG0006	proline dipeptidase activity
DNK48_RS10195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DNK48_RS10200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DNK48_RS10205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DNK48_RS10210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DNK48_RS10220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DNK48_RS10225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DNK48_RS10240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DNK48_RS10270	COG4585	Histidine kinase
DNK48_RS10275	COG2197	response regulator
DNK48_RS10280	COG0124	histidyl-tRNA synthetase
DNK48_RS10290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DNK48_RS10295	COG1196	nuclear chromosome segregation
DNK48_RS10300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DNK48_RS10305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNK48_RS10310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DNK48_RS10315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DNK48_RS10325	COG2255	four-way junction helicase activity
DNK48_RS10330	COG0632	four-way junction helicase activity
DNK48_RS10335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DNK48_RS10340	COG0217	transcriptional regulatory protein
DNK48_RS10345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DNK48_RS10350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DNK48_RS10360	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS10370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DNK48_RS10390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DNK48_RS10405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DNK48_RS10470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DNK48_RS10470	COG0512	Glutamine amidotransferase of anthranilate synthase
DNK48_RS10525	COG1733	regulation of RNA biosynthetic process
DNK48_RS10645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DNK48_RS10675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DNK48_RS10675	COG1648	precorrin-2 dehydrogenase activity
DNK48_RS10680	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DNK48_RS10695	COG1464	Belongs to the NlpA lipoprotein family
DNK48_RS10740	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS10740	COG0204	Acyl-transferase
DNK48_RS10755	COG0165	Argininosuccinate lyase
DNK48_RS10760	COG0137	argininosuccinate synthase activity
DNK48_RS10790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DNK48_RS10800	COG0583	DNA-binding transcription factor activity
DNK48_RS10810	COG0385	Bile acid
DNK48_RS10815	COG1438	arginine binding
DNK48_RS10820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DNK48_RS10825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DNK48_RS10830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DNK48_RS10835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DNK48_RS10840	COG2838	Isocitrate dehydrogenase
DNK48_RS10860	COG0697	spore germination
DNK48_RS10870	COG1649	PFAM Uncharacterised BCR, COG1649
DNK48_RS10890	COG2814	Major facilitator Superfamily
DNK48_RS10895	COG1285	pathogenesis
DNK48_RS10920	COG2860	membrane
DNK48_RS10935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNK48_RS10935	COG0072	phenylalanine-tRNA ligase activity
DNK48_RS10940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DNK48_RS10945	COG5002	protein histidine kinase activity
DNK48_RS10950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DNK48_RS10955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DNK48_RS10960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DNK48_RS10965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DNK48_RS10975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNK48_RS11020	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS11035	COG0531	amino acid
DNK48_RS11040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DNK48_RS11045	COG0596	Alpha beta hydrolase
DNK48_RS11100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DNK48_RS11125	COG2755	lipolytic protein G-D-S-L family
DNK48_RS11130	COG2365	Tyrosine phosphatase family
DNK48_RS11145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DNK48_RS11150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DNK48_RS11165	COG1657	PFAM Prenyltransferase squalene oxidase
DNK48_RS11175	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DNK48_RS11185	COG1562	ergosterol biosynthetic process
DNK48_RS11200	COG1134	teichoic acid transport
DNK48_RS11250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DNK48_RS11260	COG1024	Enoyl-CoA hydratase
DNK48_RS11280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DNK48_RS11290	COG2936	dipeptidyl-peptidase activity
DNK48_RS11295	COG0308	aminopeptidase N
DNK48_RS11305	COG3250	beta-galactosidase activity
DNK48_RS11320	COG0583	DNA-binding transcription factor activity
DNK48_RS11325	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS11325	COG1024	Enoyl-CoA hydratase
DNK48_RS11330	COG0183	Belongs to the thiolase family
DNK48_RS11335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DNK48_RS11345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNK48_RS11355	COG1515	deoxyribonuclease V activity
DNK48_RS11415	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS11435	COG0431	NADPH-dependent FMN reductase
DNK48_RS11445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS11460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS11465	COG0601	transmembrane transport
DNK48_RS11550	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DNK48_RS11560	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DNK48_RS11575	COG1309	transcriptional regulator
DNK48_RS11590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DNK48_RS11595	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DNK48_RS11620	COG0583	DNA-binding transcription factor activity
DNK48_RS11625	COG0697	spore germination
DNK48_RS11645	COG2239	Acts as a magnesium transporter
DNK48_RS11680	COG2271	Major facilitator Superfamily
DNK48_RS11685	COG1027	Aspartate ammonia-lyase
DNK48_RS11690	COG1414	Transcriptional regulator
DNK48_RS11695	COG1846	Transcriptional regulator
DNK48_RS11700	COG0697	spore germination
DNK48_RS11705	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DNK48_RS11715	COG0596	Alpha beta hydrolase
DNK48_RS11715	COG0508	dehydrogenase complex catalyzes the overall conversion of
DNK48_RS11720	COG1309	transcriptional regulator
DNK48_RS11730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DNK48_RS11740	COG0693	protein deglycase activity
DNK48_RS11765	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS11775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS11780	COG2188	Transcriptional regulator
DNK48_RS11785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DNK48_RS11790	COG2814	Major facilitator Superfamily
DNK48_RS11795	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DNK48_RS11800	COG1920	GTP binding
DNK48_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS11845	COG0045	succinate-CoA ligase (ADP-forming) activity
DNK48_RS11855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DNK48_RS11930	COG0673	inositol 2-dehydrogenase activity
DNK48_RS11935	COG1879	ABC-type sugar transport system periplasmic component
DNK48_RS11940	COG1172	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS11945	COG1129	ABC transporter
DNK48_RS11950	COG1940	carbohydrate kinase activity
DNK48_RS11970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNK48_RS11975	COG3383	formate dehydrogenase (NAD+) activity
DNK48_RS11990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DNK48_RS11995	COG1309	transcriptional regulator
DNK48_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS12015	COG0789	Transcriptional regulator
DNK48_RS12035	COG0583	DNA-binding transcription factor activity
DNK48_RS12055	COG0656	L-ascorbic acid biosynthetic process
DNK48_RS12065	COG1595	DNA-templated transcription, initiation
DNK48_RS12080	COG2154	pterin-4-alpha-carbinolamine dehydratase
DNK48_RS12095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DNK48_RS12120	COG4214	carbohydrate transport
DNK48_RS12130	COG1879	ABC-type sugar transport system periplasmic component
DNK48_RS12155	COG2267	carboxylic ester hydrolase activity
DNK48_RS12170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DNK48_RS12205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS12265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS12270	COG0028	Belongs to the TPP enzyme family
DNK48_RS12275	COG0693	protein deglycase activity
DNK48_RS12305	COG0517	IMP dehydrogenase activity
DNK48_RS12305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DNK48_RS12305	COG0617	tRNA 3'-terminal CCA addition
DNK48_RS12310	COG4106	trans-aconitate 2-methyltransferase activity
DNK48_RS12350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNK48_RS12355	COG2362	D-Aminopeptidase
DNK48_RS12365	COG1366	Belongs to the anti-sigma-factor antagonist family
DNK48_RS12365	COG2208	phosphoserine phosphatase activity
DNK48_RS12365	COG2172	sigma factor antagonist activity
DNK48_RS12390	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS12395	COG1309	transcriptional regulator
DNK48_RS12405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS12405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS12410	COG2301	Belongs to the HpcH HpaI aldolase family
DNK48_RS12420	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS12425	COG0688	phosphatidylethanolamine metabolic process
DNK48_RS12435	COG1929	Belongs to the glycerate kinase type-1 family
DNK48_RS12460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DNK48_RS12505	COG0181	hydroxymethylbilane synthase activity
DNK48_RS12515	COG0483	inositol monophosphate 1-phosphatase activity
DNK48_RS12535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DNK48_RS12540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DNK48_RS12560	COG0477	Major facilitator Superfamily
DNK48_RS12565	COG1335	isochorismatase
DNK48_RS12570	COG0405	Gamma-glutamyltransferase
DNK48_RS12605	COG0765	amino acid transport
DNK48_RS12610	COG0765	amino acid transport
DNK48_RS12615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNK48_RS12620	COG1126	abc transporter atp-binding protein
DNK48_RS12645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNK48_RS12655	COG1940	carbohydrate kinase activity
DNK48_RS12675	COG2188	Transcriptional regulator
DNK48_RS12700	COG0800	Aldolase
DNK48_RS12740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DNK48_RS12745	COG4266	Belongs to the allantoicase family
DNK48_RS12750	COG1953	Uracil, thiamine, allantoin
DNK48_RS12755	COG1414	Transcriptional regulator
DNK48_RS12765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DNK48_RS12770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DNK48_RS12785	COG2351	hydroxyisourate hydrolase activity
DNK48_RS12810	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS12815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS12820	COG2197	response regulator
DNK48_RS12825	COG0598	Magnesium transport protein CorA
DNK48_RS12830	COG0823	Involved in the tonB-independent uptake of proteins
DNK48_RS12845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS12875	COG1802	Transcriptional regulator
DNK48_RS12910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DNK48_RS12915	COG0698	ribose 5-phosphate isomerase
DNK48_RS12930	COG0028	Belongs to the TPP enzyme family
DNK48_RS12940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNK48_RS12950	COG0583	DNA-binding transcription factor activity
DNK48_RS12960	COG1162	GTPase activity
DNK48_RS13010	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DNK48_RS13050	COG0175	sulfate reduction
DNK48_RS13055	COG0529	Catalyzes the synthesis of activated sulfate
DNK48_RS13080	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DNK48_RS13085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS13130	COG2409	Drug exporters of the RND superfamily
DNK48_RS13135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DNK48_RS13155	COG1175	transmembrane transport
DNK48_RS13175	COG1119	ATPase activity
DNK48_RS13305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DNK48_RS13310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DNK48_RS13355	COG5002	protein histidine kinase activity
DNK48_RS13360	COG0745	RESPONSE REGULATOR receiver
DNK48_RS13415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNK48_RS13420	COG3220	belongs to the UPF0276 family
DNK48_RS13440	COG3253	May function as heme-dependent peroxidase
DNK48_RS13445	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DNK48_RS13450	COG1414	Transcriptional regulator
DNK48_RS13470	COG2271	Major facilitator Superfamily
DNK48_RS13475	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNK48_RS13485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DNK48_RS13505	COG0183	Belongs to the thiolase family
DNK48_RS13510	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS13510	COG1024	Enoyl-CoA hydratase
DNK48_RS13525	COG0531	amino acid
DNK48_RS13530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DNK48_RS13535	COG4214	carbohydrate transport
DNK48_RS13545	COG4213	ABC transporter substrate-binding protein
DNK48_RS13550	COG1940	carbohydrate kinase activity
DNK48_RS13555	COG0395	ABC-type sugar transport system, permease component
DNK48_RS13560	COG1175	transmembrane transport
DNK48_RS13565	COG1653	transport
DNK48_RS13590	COG3537	Alpha-1,2-mannosidase
DNK48_RS13600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DNK48_RS13625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DNK48_RS13630	COG3345	alpha-galactosidase
DNK48_RS13640	COG1175	transmembrane transport
DNK48_RS13645	COG0395	ABC-type sugar transport system, permease component
DNK48_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS13665	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS13675	COG0800	Aldolase
DNK48_RS13680	COG3386	PFAM SMP-30 Gluconolaconase
DNK48_RS13695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DNK48_RS13725	COG4977	sequence-specific DNA binding
DNK48_RS13730	COG2040	homocysteine
DNK48_RS13760	COG2409	Drug exporters of the RND superfamily
DNK48_RS13770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DNK48_RS13775	COG1819	glycosyl
DNK48_RS13785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DNK48_RS13795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DNK48_RS13810	COG1233	COG1233 Phytoene dehydrogenase and related
DNK48_RS13840	COG2124	cytochrome p450
DNK48_RS13845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS13855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS13865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS13870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS13885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNK48_RS13890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNK48_RS13895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS13915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS13920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS13925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS13930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS13985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DNK48_RS14000	COG2124	cytochrome p450
DNK48_RS14025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DNK48_RS14030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DNK48_RS14040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DNK48_RS14045	COG0531	amino acid
DNK48_RS14080	COG0569	domain protein
DNK48_RS14120	COG0756	dUTP diphosphatase activity
DNK48_RS14145	COG2205	protein histidine kinase activity
DNK48_RS14150	COG0745	RESPONSE REGULATOR receiver
DNK48_RS14155	COG0483	inositol monophosphate 1-phosphatase activity
DNK48_RS14160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DNK48_RS14195	COG1435	thymidine kinase activity
DNK48_RS14210	COG0045	succinate-CoA ligase (ADP-forming) activity
DNK48_RS14210	COG1042	CoA-binding domain protein
DNK48_RS14210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DNK48_RS14215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNK48_RS14220	COG1802	Transcriptional regulator
DNK48_RS14235	COG0612	Peptidase, M16
DNK48_RS14240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DNK48_RS14255	COG3290	protein histidine kinase activity
DNK48_RS14260	COG4565	transcriptional regulatory protein
DNK48_RS14265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNK48_RS14275	COG0187	DNA topoisomerase II activity
DNK48_RS14290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DNK48_RS14295	COG1802	Transcriptional regulator
DNK48_RS14300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNK48_RS14330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DNK48_RS14345	COG0488	(ABC) transporter
DNK48_RS14360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNK48_RS14365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DNK48_RS14370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DNK48_RS14400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DNK48_RS14410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DNK48_RS14415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DNK48_RS14425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DNK48_RS14445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DNK48_RS14450	COG1414	Transcriptional regulator
DNK48_RS14460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DNK48_RS14465	COG2205	protein histidine kinase activity
DNK48_RS14470	COG0745	RESPONSE REGULATOR receiver
DNK48_RS14475	COG1126	abc transporter atp-binding protein
DNK48_RS14480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DNK48_RS14485	COG0765	amino acid transport
DNK48_RS14490	COG0765	amino acid transport
DNK48_RS14495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS14505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DNK48_RS14550	COG1201	RNA secondary structure unwinding
DNK48_RS14555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNK48_RS14570	COG1396	sequence-specific DNA binding
DNK48_RS14575	COG1058	Belongs to the CinA family
DNK48_RS14575	COG1546	Belongs to the CinA family
DNK48_RS14585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DNK48_RS14595	COG1674	ftsk spoiiie
DNK48_RS14605	COG3850	Histidine kinase
DNK48_RS14605	COG3437	response regulator, receiver
DNK48_RS14605	COG4999	Histidine kinase
DNK48_RS14605	COG2205	protein histidine kinase activity
DNK48_RS14610	COG2770	Histidine kinase
DNK48_RS14610	COG2208	phosphoserine phosphatase activity
DNK48_RS14645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DNK48_RS14650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNK48_RS14655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DNK48_RS14675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DNK48_RS14680	COG0612	Peptidase, M16
DNK48_RS14685	COG1185	polyribonucleotide nucleotidyltransferase activity
DNK48_RS14690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DNK48_RS14700	COG0515	serine threonine protein kinase
DNK48_RS14700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DNK48_RS14725	COG1674	ftsk spoiiie
DNK48_RS14745	COG1404	Belongs to the peptidase S8 family
DNK48_RS14760	COG1674	ftsk spoiiie
DNK48_RS14805	COG1404	Belongs to the peptidase S8 family
DNK48_RS14830	COG0455	bacterial-type flagellum organization
DNK48_RS14840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DNK48_RS14845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DNK48_RS14860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DNK48_RS14875	COG0779	Required for maturation of 30S ribosomal subunits
DNK48_RS14905	COG0442	prolyl-tRNA aminoacylation
DNK48_RS14920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DNK48_RS14925	COG0750	zinc metalloprotease
DNK48_RS14930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DNK48_RS14940	COG1609	Transcriptional regulator
DNK48_RS14960	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS14965	COG2508	Transcriptional regulator
DNK48_RS14985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNK48_RS14990	COG1177	transmembrane transport
DNK48_RS14995	COG1176	ABC-type spermidine putrescine transport system, permease component I
DNK48_RS15000	COG3842	ATPase activity
DNK48_RS15010	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS15020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DNK48_RS15035	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS15045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DNK48_RS15060	COG0028	Belongs to the TPP enzyme family
DNK48_RS15065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNK48_RS15080	COG3842	ATPase activity
DNK48_RS15085	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DNK48_RS15095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DNK48_RS15100	COG0575	Belongs to the CDS family
DNK48_RS15105	COG0233	cytoplasmic translational termination
DNK48_RS15110	COG0528	UMP kinase activity
DNK48_RS15115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DNK48_RS15120	COG0052	Belongs to the universal ribosomal protein uS2 family
DNK48_RS15135	COG1191	sigma factor activity
DNK48_RS15150	COG0792	nuclease activity
DNK48_RS15160	COG1051	belongs to the nudix hydrolase family
DNK48_RS15165	COG0681	Belongs to the peptidase S26 family
DNK48_RS15170	COG0681	Belongs to the peptidase S26 family
DNK48_RS15175	COG0681	Belongs to the peptidase S26 family
DNK48_RS15180	COG0681	Belongs to the peptidase S26 family
DNK48_RS15185	COG0335	large ribosomal subunit rRNA binding
DNK48_RS15190	COG0336	Belongs to the RNA methyltransferase TrmD family
DNK48_RS15195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DNK48_RS15200	COG1837	Belongs to the UPF0109 family
DNK48_RS15205	COG0228	four-way junction DNA binding
DNK48_RS15215	COG0442	prolyl-tRNA aminoacylation
DNK48_RS15230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DNK48_RS15260	COG2197	response regulator
DNK48_RS15265	COG4585	Histidine kinase
DNK48_RS15285	COG0477	Major facilitator Superfamily
DNK48_RS15300	COG1254	Belongs to the acylphosphatase family
DNK48_RS15305	COG2340	Cysteine-rich secretory protein family
DNK48_RS15310	COG1733	regulation of RNA biosynthetic process
DNK48_RS15315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNK48_RS15320	COG0571	ribonuclease III activity
DNK48_RS15325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DNK48_RS15340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DNK48_RS15345	COG0742	ribosomal rna small subunit methyltransferase
DNK48_RS15350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DNK48_RS15355	COG1461	Dihydroxyacetone kinase
DNK48_RS15360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DNK48_RS15365	COG0351	phosphomethylpyrimidine kinase
DNK48_RS15385	COG1181	Belongs to the D-alanine--D-alanine ligase family
DNK48_RS15390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DNK48_RS15400	COG1920	GTP binding
DNK48_RS15405	COG0776	regulation of translation
DNK48_RS15415	COG0066	3-isopropylmalate dehydratase activity
DNK48_RS15420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DNK48_RS15425	COG1414	Transcriptional regulator
DNK48_RS15465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DNK48_RS15470	COG0179	Fumarylacetoacetate (FAA) hydrolase
DNK48_RS15485	COG2018	Roadblock/LC7 domain
DNK48_RS15505	COG2018	Roadblock/LC7 domain
DNK48_RS15525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DNK48_RS15530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DNK48_RS15535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DNK48_RS15540	COG0473	3-isopropylmalate dehydrogenase activity
DNK48_RS15555	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS15560	COG0506	proline dehydrogenase activity
DNK48_RS15610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNK48_RS15615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DNK48_RS15620	COG0440	acetolactate synthase activity
DNK48_RS15640	COG0667	Aldo Keto reductase
DNK48_RS15645	COG2133	pyrroloquinoline quinone binding
DNK48_RS15650	COG1672	PFAM Archaeal ATPase
DNK48_RS15650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DNK48_RS15660	COG2409	Drug exporters of the RND superfamily
DNK48_RS15675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNK48_RS15685	COG0154	amidase activity
DNK48_RS15690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNK48_RS15700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNK48_RS15710	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS15720	COG1819	glycosyl
DNK48_RS15725	COG0789	Transcriptional regulator
DNK48_RS15735	COG0482	sulfurtransferase activity
DNK48_RS15760	COG0596	Alpha beta hydrolase
DNK48_RS15775	COG2860	membrane
DNK48_RS15780	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS15785	COG0444	Belongs to the ABC transporter superfamily
DNK48_RS15795	COG4166	transmembrane transport
DNK48_RS15820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DNK48_RS15825	COG0509	glycine decarboxylation via glycine cleavage system
DNK48_RS15830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DNK48_RS15835	COG1760	l-serine dehydratase
DNK48_RS15850	COG1846	Transcriptional regulator
DNK48_RS15875	COG1597	lipid kinase activity
DNK48_RS15925	COG1132	(ABC) transporter
DNK48_RS15930	COG1132	(ABC) transporter
DNK48_RS15960	COG3340	Belongs to the peptidase S51 family
DNK48_RS15985	COG3344	reverse transcriptase
DNK48_RS15995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DNK48_RS16010	COG0058	SHG alpha-glucan phosphorylase activity
DNK48_RS16015	COG3401	FG-GAP repeat protein
DNK48_RS16035	COG0366	Alpha amylase catalytic
DNK48_RS16045	COG3281	Trehalose synthase
DNK48_RS16050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DNK48_RS16065	COG1301	dicarboxylic acid transport
DNK48_RS16070	COG3290	protein histidine kinase activity
DNK48_RS16075	COG4565	transcriptional regulatory protein
DNK48_RS16080	COG3469	chitinase activity
DNK48_RS16090	COG1175	transmembrane transport
DNK48_RS16120	COG1309	transcriptional regulator
DNK48_RS16125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS16145	COG1316	TRANSCRIPTIONal
DNK48_RS16160	COG3833	ABC-type maltose transport systems, permease component
DNK48_RS16180	COG0205	6-phosphofructokinase activity
DNK48_RS16185	COG0280	phosphate acetyltransferase
DNK48_RS16185	COG0857	belongs to the CobB CobQ family
DNK48_RS16190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DNK48_RS16230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS16230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS16285	COG2205	protein histidine kinase activity
DNK48_RS16290	COG0745	RESPONSE REGULATOR receiver
DNK48_RS16305	COG0183	Belongs to the thiolase family
DNK48_RS16355	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DNK48_RS16365	COG0667	Aldo Keto reductase
DNK48_RS16385	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS16415	COG4585	Histidine kinase
DNK48_RS16420	COG2197	response regulator
DNK48_RS16430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DNK48_RS16435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DNK48_RS16440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DNK48_RS16445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DNK48_RS16450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNK48_RS16455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DNK48_RS16460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNK48_RS16480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DNK48_RS16485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DNK48_RS16495	COG2890	protein-(glutamine-N5) methyltransferase activity
DNK48_RS16500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DNK48_RS16505	COG0254	rRNA binding
DNK48_RS16510	COG1316	TRANSCRIPTIONal
DNK48_RS16520	COG0083	homoserine kinase activity
DNK48_RS16525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DNK48_RS16530	COG0460	homoserine dehydrogenase
DNK48_RS16535	COG0019	diaminopimelate decarboxylase activity
DNK48_RS16540	COG0018	arginyl-trna synthetase
DNK48_RS16545	COG0745	RESPONSE REGULATOR receiver
DNK48_RS16680	COG0477	Major facilitator Superfamily
DNK48_RS16720	COG1388	LysM domain
DNK48_RS16720	COG3103	Sh3 type 3 domain protein
DNK48_RS16720	COG0791	NLP P60 protein
DNK48_RS16770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DNK48_RS16785	COG0745	RESPONSE REGULATOR receiver
DNK48_RS16790	COG2205	protein histidine kinase activity
DNK48_RS16795	COG0508	dehydrogenase complex catalyzes the overall conversion of
DNK48_RS16795	COG0567	Dehydrogenase, E1 component
DNK48_RS16805	COG0789	Transcriptional regulator
DNK48_RS16830	COG0778	Nitroreductase
DNK48_RS16845	COG0300	oxidoreductase activity
DNK48_RS16845	COG3321	synthase
DNK48_RS16845	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS16845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS16870	COG0281	malic enzyme
DNK48_RS16880	COG0765	amino acid transport
DNK48_RS16930	COG0583	DNA-binding transcription factor activity
DNK48_RS16935	COG5640	endopeptidase activity
DNK48_RS16960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DNK48_RS16980	COG2066	Belongs to the glutaminase family
DNK48_RS17020	COG1597	lipid kinase activity
DNK48_RS17035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DNK48_RS17040	COG1472	Belongs to the glycosyl hydrolase 3 family
DNK48_RS17045	COG0395	ABC-type sugar transport system, permease component
DNK48_RS17050	COG1175	transmembrane transport
DNK48_RS17055	COG2182	Extracellular solute-binding protein
DNK48_RS17060	COG2188	Transcriptional regulator
DNK48_RS17145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNK48_RS17150	COG0242	peptide deformylase activity
DNK48_RS17165	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DNK48_RS17165	COG2199	diguanylate cyclase activity
DNK48_RS17170	COG5662	AntiSigma factor
DNK48_RS17175	COG1595	DNA-templated transcription, initiation
DNK48_RS17185	COG2135	peptidase activity
DNK48_RS17195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DNK48_RS17200	COG1162	GTPase activity
DNK48_RS17215	COG0483	inositol monophosphate 1-phosphatase activity
DNK48_RS17225	COG0753	catalase activity
DNK48_RS17250	COG1615	UPF0182 protein
DNK48_RS17260	COG3480	Lon protease (S16) C-terminal proteolytic domain
DNK48_RS17315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DNK48_RS17360	COG0210	DNA helicase
DNK48_RS17460	COG1432	Conserved Protein
DNK48_RS17465	COG2095	MarC family integral membrane protein
DNK48_RS17470	COG0613	PHP domain protein
DNK48_RS17485	COG0598	Magnesium transport protein CorA
DNK48_RS17525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DNK48_RS17530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNK48_RS17540	COG1595	DNA-templated transcription, initiation
DNK48_RS17555	COG1024	Enoyl-CoA hydratase
DNK48_RS17560	COG0519	Catalyzes the synthesis of GMP from XMP
DNK48_RS17570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DNK48_RS17575	COG1611	Belongs to the LOG family
DNK48_RS17580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNK48_RS17610	COG2912	Transglutaminase-like superfamily
DNK48_RS17615	COG2197	response regulator
DNK48_RS17620	COG4585	Histidine kinase
DNK48_RS17630	COG1131	(ABC) transporter
DNK48_RS17650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DNK48_RS17670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS17675	COG0747	negative chemotaxis
DNK48_RS17685	COG0444	Belongs to the ABC transporter superfamily
DNK48_RS17690	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS17705	COG0596	Alpha beta hydrolase
DNK48_RS17710	COG4166	transmembrane transport
DNK48_RS17715	COG0601	transmembrane transport
DNK48_RS17720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS17725	COG0444	Belongs to the ABC transporter superfamily
DNK48_RS17730	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS17760	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS17765	COG0444	Belongs to the ABC transporter superfamily
DNK48_RS17770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS17775	COG0601	transmembrane transport
DNK48_RS17785	COG1217	gtp-binding protein TYPA
DNK48_RS17805	COG1053	succinate dehydrogenase
DNK48_RS17855	COG2223	nitrite transmembrane transporter activity
DNK48_RS17880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNK48_RS17885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DNK48_RS17905	COG1091	dTDP-4-dehydrorhamnose reductase activity
DNK48_RS17910	COG1063	alcohol dehydrogenase
DNK48_RS17925	COG4115	mRNA cleavage
DNK48_RS17930	COG2161	toxin-antitoxin pair type II binding
DNK48_RS17945	COG0745	RESPONSE REGULATOR receiver
DNK48_RS17950	COG1132	(ABC) transporter
DNK48_RS17965	COG2205	protein histidine kinase activity
DNK48_RS17990	COG1136	(ABC) transporter
DNK48_RS17990	COG0577	efflux transmembrane transporter activity
DNK48_RS18105	COG0066	3-isopropylmalate dehydratase activity
DNK48_RS18110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DNK48_RS18120	COG4106	trans-aconitate 2-methyltransferase activity
DNK48_RS18120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DNK48_RS18140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DNK48_RS18145	COG0243	molybdopterin cofactor binding
DNK48_RS18155	COG0583	DNA-binding transcription factor activity
DNK48_RS18195	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS18235	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS18240	COG0179	Fumarylacetoacetate (FAA) hydrolase
DNK48_RS18245	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS18330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DNK48_RS18365	COG1136	(ABC) transporter
DNK48_RS18385	COG3547	Transposase (IS116 IS110 IS902 family)
DNK48_RS18390	COG0012	GTP binding
DNK48_RS18405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DNK48_RS18410	COG1570	exodeoxyribonuclease VII activity
DNK48_RS18415	COG1722	exodeoxyribonuclease VII activity
DNK48_RS18420	COG0778	Nitroreductase
DNK48_RS18445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DNK48_RS18445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DNK48_RS18475	COG4106	trans-aconitate 2-methyltransferase activity
DNK48_RS18505	COG3979	chitinase
DNK48_RS18520	COG0114	fumarate hydratase activity
DNK48_RS18530	COG2264	protein methyltransferase activity
DNK48_RS18540	COG1309	transcriptional regulator
DNK48_RS18545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DNK48_RS18550	COG1082	Xylose isomerase domain protein TIM barrel
DNK48_RS18550	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DNK48_RS18570	COG3409	Peptidoglycan-binding domain 1 protein
DNK48_RS18610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNK48_RS18630	COG1136	(ABC) transporter
DNK48_RS18645	COG0450	alkyl hydroperoxide reductase
DNK48_RS18650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNK48_RS18680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DNK48_RS18690	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DNK48_RS18715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DNK48_RS18720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DNK48_RS18735	COG1278	Cold shock
DNK48_RS18740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DNK48_RS18745	COG2885	chlorophyll binding
DNK48_RS18840	COG0513	Belongs to the DEAD box helicase family
DNK48_RS18845	COG1278	Cold shock
DNK48_RS18865	COG1131	(ABC) transporter
DNK48_RS18870	COG2610	gluconate transmembrane transporter activity
DNK48_RS18875	COG0251	oxidation-reduction process
DNK48_RS18880	COG1414	Transcriptional regulator
DNK48_RS18895	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DNK48_RS18925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS18930	COG0601	transmembrane transport
DNK48_RS18950	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DNK48_RS18955	COG1272	protein, Hemolysin III
DNK48_RS18965	COG1331	Highly conserved protein containing a thioredoxin domain
DNK48_RS18970	COG3903	Transcriptional regulator
DNK48_RS18970	COG3629	intracellular signal transduction
DNK48_RS18980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DNK48_RS18990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DNK48_RS19005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DNK48_RS19035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DNK48_RS19040	COG2318	DinB family
DNK48_RS19115	COG2226	methyltransferase
DNK48_RS19145	COG0601	transmembrane transport
DNK48_RS19150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS19160	COG4608	Belongs to the ABC transporter superfamily
DNK48_RS19200	COG2084	Dehydrogenase
DNK48_RS19205	COG1082	Xylose isomerase domain protein TIM barrel
DNK48_RS19210	COG0149	triose-phosphate isomerase activity
DNK48_RS19215	COG0698	ribose 5-phosphate isomerase
DNK48_RS19220	COG2376	Dihydroxyacetone kinase
DNK48_RS19285	COG0577	efflux transmembrane transporter activity
DNK48_RS19290	COG1136	(ABC) transporter
DNK48_RS19295	COG0477	Major facilitator Superfamily
DNK48_RS19330	COG4585	Histidine kinase
DNK48_RS19340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DNK48_RS19345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DNK48_RS19350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DNK48_RS19355	COG0193	aminoacyl-tRNA hydrolase activity
DNK48_RS19365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DNK48_RS19375	COG1309	transcriptional regulator
DNK48_RS19385	COG4106	trans-aconitate 2-methyltransferase activity
DNK48_RS19395	COG2197	response regulator
DNK48_RS19400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DNK48_RS19435	COG0488	(ABC) transporter
DNK48_RS19440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DNK48_RS19445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DNK48_RS19450	COG3583	domain protein
DNK48_RS19450	COG3584	3D domain protein
DNK48_RS19455	COG0084	hydrolase, TatD family'
DNK48_RS19515	COG4166	transmembrane transport
DNK48_RS19530	COG1122	ATPase activity
DNK48_RS19540	COG0310	cobalt ion transport
DNK48_RS19550	COG1309	transcriptional regulator
DNK48_RS19555	COG2409	Drug exporters of the RND superfamily
DNK48_RS19565	COG0793	Belongs to the peptidase S41A family
DNK48_RS19565	COG4946	Tricorn protease homolog
DNK48_RS19580	COG2267	carboxylic ester hydrolase activity
DNK48_RS19585	COG2072	flavoprotein involved in K transport
DNK48_RS19590	COG0789	Transcriptional regulator
DNK48_RS19595	COG0708	Exodeoxyribonuclease III
DNK48_RS19615	COG0783	Belongs to the Dps family
DNK48_RS19630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DNK48_RS19635	COG0521	Mo-molybdopterin cofactor biosynthetic process
DNK48_RS19640	COG0315	cyclic pyranopterin monophosphate synthase activity
DNK48_RS19650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DNK48_RS19655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DNK48_RS19665	COG3263	regulation of cellular component size
DNK48_RS19675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DNK48_RS19685	COG1970	mechanosensitive ion channel activity
DNK48_RS19695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS19700	COG3191	aminopeptidase activity
DNK48_RS19710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNK48_RS19710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNK48_RS19710	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DNK48_RS19715	COG1105	Belongs to the carbohydrate kinase PfkB family
DNK48_RS19720	COG1349	DNA-binding transcription factor activity
DNK48_RS19725	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS19745	COG3384	dioxygenase
DNK48_RS19750	COG1846	Transcriptional regulator
DNK48_RS19805	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DNK48_RS19860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DNK48_RS19890	COG4221	oxidoreductase activity
DNK48_RS19925	COG0494	nUDIX hydrolase
DNK48_RS19930	COG0494	nUDIX hydrolase
DNK48_RS19955	COG1175	transmembrane transport
DNK48_RS19960	COG0395	ABC-type sugar transport system, permease component
DNK48_RS19980	COG0640	Transcriptional regulator
DNK48_RS20005	COG0596	Alpha beta hydrolase
DNK48_RS20020	COG0515	serine threonine protein kinase
DNK48_RS20030	COG3246	L-lysine catabolic process to acetate
DNK48_RS20035	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS20040	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS20040	COG0824	Thioesterase
DNK48_RS20055	COG0640	Transcriptional regulator
DNK48_RS20060	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DNK48_RS20065	COG1793	dna ligase
DNK48_RS20075	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DNK48_RS20085	COG1309	transcriptional regulator
DNK48_RS20110	COG0515	serine threonine protein kinase
DNK48_RS20125	COG1653	transport
DNK48_RS20135	COG1686	Belongs to the peptidase S11 family
DNK48_RS20265	COG1024	Enoyl-CoA hydratase
DNK48_RS20280	COG0515	serine threonine protein kinase
DNK48_RS20280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DNK48_RS20290	COG1309	transcriptional regulator
DNK48_RS20300	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS20310	COG0259	pyridoxamine-phosphate oxidase activity
DNK48_RS20325	COG2072	flavoprotein involved in K transport
DNK48_RS20335	COG1024	Enoyl-CoA hydratase
DNK48_RS20340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNK48_RS20365	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS20385	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS20390	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS20395	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS20400	COG3547	Transposase (IS116 IS110 IS902 family)
DNK48_RS20420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DNK48_RS20435	COG1077	Cell shape determining protein MreB Mrl
DNK48_RS20450	COG0516	GMP reductase activity
DNK48_RS20460	COG1595	DNA-templated transcription, initiation
DNK48_RS20465	COG2197	response regulator
DNK48_RS20475	COG0583	DNA-binding transcription factor activity
DNK48_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS20490	COG0459	protein refolding
DNK48_RS20495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DNK48_RS20500	COG0726	polysaccharide deacetylase
DNK48_RS20550	COG0596	Alpha beta hydrolase
DNK48_RS20555	COG3903	Transcriptional regulator
DNK48_RS20555	COG3629	intracellular signal transduction
DNK48_RS20560	COG0667	Aldo Keto reductase
DNK48_RS20565	COG0583	DNA-binding transcription factor activity
DNK48_RS20575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DNK48_RS20600	COG0802	atpase or kinase
DNK48_RS20610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DNK48_RS20635	COG0736	holo-[acyl-carrier-protein] synthase activity
DNK48_RS20640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DNK48_RS20645	COG1072	(Pantothenic acid kinase))
DNK48_RS20655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNK48_RS20660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DNK48_RS20665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DNK48_RS20690	COG2208	phosphoserine phosphatase activity
DNK48_RS20690	COG2770	Histidine kinase
DNK48_RS20700	COG2172	sigma factor antagonist activity
DNK48_RS20705	COG1366	Belongs to the anti-sigma-factor antagonist family
DNK48_RS20710	COG1366	Belongs to the anti-sigma-factor antagonist family
DNK48_RS20715	COG0101	tRNA pseudouridine synthase activity
DNK48_RS20720	COG0203	ribosomal protein L17
DNK48_RS20725	COG0202	RNA polymerase activity
DNK48_RS20730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DNK48_RS20735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DNK48_RS20740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DNK48_RS20745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DNK48_RS20750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DNK48_RS20760	COG0563	adenylate kinase activity
DNK48_RS20770	COG0200	Binds to the 23S rRNA
DNK48_RS20780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DNK48_RS20785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DNK48_RS20790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DNK48_RS20795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DNK48_RS20805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DNK48_RS20810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DNK48_RS20815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DNK48_RS20820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DNK48_RS20825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DNK48_RS20830	COG0255	Belongs to the universal ribosomal protein uL29 family
DNK48_RS20835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DNK48_RS20840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DNK48_RS20845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DNK48_RS20850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DNK48_RS20855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DNK48_RS20860	COG0089	rRNA binding
DNK48_RS20865	COG0088	Forms part of the polypeptide exit tunnel
DNK48_RS20870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DNK48_RS20875	COG0051	transcription antitermination factor activity, RNA binding
DNK48_RS20890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DNK48_RS20895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DNK48_RS20900	COG0049	tRNA binding
DNK48_RS20905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DNK48_RS20940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DNK48_RS20945	COG0085	RNA polymerase activity
DNK48_RS20955	COG0222	ribosome binding
DNK48_RS20960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DNK48_RS20970	COG0081	regulation of translation
DNK48_RS20975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DNK48_RS20995	COG0436	Aminotransferase
DNK48_RS21000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DNK48_RS21005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DNK48_RS21015	COG2030	dehydratase
DNK48_RS21020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNK48_RS21040	COG0702	epimerase
DNK48_RS21055	COG1970	mechanosensitive ion channel activity
DNK48_RS21080	COG1666	GTP binding
DNK48_RS21085	COG3304	Inner membrane component domain
DNK48_RS21095	COG1007	ATP synthesis coupled electron transport
DNK48_RS21105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DNK48_RS21110	COG0713	ATP synthesis coupled electron transport
DNK48_RS21115	COG0839	Belongs to the complex I subunit 6 family
DNK48_RS21120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DNK48_RS21125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DNK48_RS21135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DNK48_RS21140	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DNK48_RS21145	COG4585	Histidine kinase
DNK48_RS21150	COG4585	Histidine kinase
DNK48_RS21165	COG1013	pyruvate-flavodoxin oxidoreductase activity
DNK48_RS21180	COG0702	epimerase
DNK48_RS21210	COG0142	geranyltranstransferase activity
DNK48_RS21215	COG0492	ferredoxin-NADP+ reductase activity
DNK48_RS21250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DNK48_RS21255	COG0713	ATP synthesis coupled electron transport
DNK48_RS21260	COG0839	Belongs to the complex I subunit 6 family
DNK48_RS21265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DNK48_RS21270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DNK48_RS21280	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DNK48_RS21290	COG0649	NAD binding
DNK48_RS21295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DNK48_RS21300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DNK48_RS21330	COG2226	methyltransferase
DNK48_RS21340	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DNK48_RS21355	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DNK48_RS21360	COG1278	Cold shock
DNK48_RS21380	COG1309	transcriptional regulator
DNK48_RS21390	COG2076	Multidrug Resistance protein
DNK48_RS21395	COG1301	dicarboxylic acid transport
DNK48_RS21410	COG1573	uracil-dna glycosylase
DNK48_RS21415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DNK48_RS21425	COG0163	prenyltransferase activity
DNK48_RS21430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DNK48_RS21435	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DNK48_RS21445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DNK48_RS21450	COG1333	cytochrome c biogenesis protein
DNK48_RS21460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNK48_RS21470	COG0406	alpha-ribazole phosphatase activity
DNK48_RS21475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DNK48_RS21500	COG1742	UPF0060 membrane protein
DNK48_RS21520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DNK48_RS21530	COG1690	Belongs to the RtcB family
DNK48_RS21550	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DNK48_RS21555	COG0018	arginyl-trna synthetase
DNK48_RS21575	COG1072	(Pantothenic acid kinase))
DNK48_RS21580	COG0113	porphobilinogen synthase activity
DNK48_RS21585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DNK48_RS21585	COG1648	precorrin-2 dehydrogenase activity
DNK48_RS21590	COG0181	hydroxymethylbilane synthase activity
DNK48_RS21595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DNK48_RS21600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DNK48_RS21650	COG0123	including yeast histone deacetylase and acetoin utilization protein
DNK48_RS21660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNK48_RS21685	COG0180	Tryptophanyl-tRNA synthetase
DNK48_RS21690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DNK48_RS21720	COG0129	dihydroxy-acid dehydratase activity
DNK48_RS21730	COG1082	Xylose isomerase domain protein TIM barrel
DNK48_RS21735	COG0248	Ppx GppA phosphatase
DNK48_RS21755	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DNK48_RS21765	COG1194	a g-specific adenine glycosylase
DNK48_RS21770	COG1595	DNA-templated transcription, initiation
DNK48_RS21785	COG2205	protein histidine kinase activity
DNK48_RS21790	COG0346	lactoylglutathione lyase activity
DNK48_RS21810	COG0739	heme binding
DNK48_RS21860	COG0724	RNA recognition motif
DNK48_RS21885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNK48_RS21890	COG1609	Transcriptional regulator
DNK48_RS21895	COG0745	RESPONSE REGULATOR receiver
DNK48_RS21930	COG2897	thiosulfate sulfurtransferase activity
DNK48_RS21950	COG3485	protocatechuate 3,4-dioxygenase
DNK48_RS21955	COG0735	belongs to the Fur family
DNK48_RS21965	COG1490	D-aminoacyl-tRNA deacylase activity
DNK48_RS21975	COG4552	Acetyltransferase involved in intracellular survival and related
DNK48_RS22015	COG0667	Aldo Keto reductase
DNK48_RS22020	COG4941	Belongs to the sigma-70 factor family
DNK48_RS22050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DNK48_RS22075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DNK48_RS22080	COG0306	phosphate transporter
DNK48_RS22090	COG1937	Protein conserved in bacteria
DNK48_RS22115	COG0671	phosphoesterase, PA-phosphatase related
DNK48_RS22120	COG0741	lytic transglycosylase activity
DNK48_RS22120	COG0739	heme binding
DNK48_RS22120	COG1196	nuclear chromosome segregation
DNK48_RS22180	COG1846	Transcriptional regulator
DNK48_RS22195	COG1252	NADH dehydrogenase
DNK48_RS22220	COG0579	oxidoreductase
DNK48_RS22225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DNK48_RS22245	COG1376	ErfK ybiS ycfS ynhG family protein
DNK48_RS22255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DNK48_RS22325	COG0667	Aldo Keto reductase
DNK48_RS22375	COG0513	Belongs to the DEAD box helicase family
DNK48_RS22465	COG1643	Atp-dependent helicase
DNK48_RS22490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DNK48_RS22500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DNK48_RS22520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DNK48_RS22525	COG0047	phosphoribosylformylglycinamidine synthase activity
DNK48_RS22530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DNK48_RS22560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DNK48_RS22580	COG0151	Belongs to the GarS family
DNK48_RS22595	COG1802	Transcriptional regulator
DNK48_RS22620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DNK48_RS22620	COG0515	serine threonine protein kinase
DNK48_RS22625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DNK48_RS22635	COG3321	synthase
DNK48_RS22635	COG0604	alcohol dehydrogenase
DNK48_RS22635	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS22645	COG1131	(ABC) transporter
DNK48_RS22650	COG3559	Exporter of polyketide antibiotics
DNK48_RS22660	COG2197	response regulator
DNK48_RS22675	COG3844	kynureninase activity
DNK48_RS22690	COG0477	Major facilitator Superfamily
DNK48_RS22695	COG0191	fructose-bisphosphate aldolase activity
DNK48_RS22700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DNK48_RS22715	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DNK48_RS22760	COG0542	response to heat
DNK48_RS22770	COG0477	Major facilitator Superfamily
DNK48_RS22780	COG0789	Transcriptional regulator
DNK48_RS22785	COG0484	heat shock protein binding
DNK48_RS22790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DNK48_RS22795	COG0443	Heat shock 70 kDa protein
DNK48_RS22800	COG2181	nitrate reductase activity
DNK48_RS22800	COG0247	lactate metabolic process
DNK48_RS22805	COG3290	protein histidine kinase activity
DNK48_RS22820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DNK48_RS22825	COG0717	Belongs to the dCTP deaminase family
DNK48_RS22875	COG0179	Fumarylacetoacetate (FAA) hydrolase
DNK48_RS22885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DNK48_RS22930	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS22955	COG0726	polysaccharide deacetylase
DNK48_RS22975	COG3903	Transcriptional regulator
DNK48_RS22975	COG3629	intracellular signal transduction
DNK48_RS23005	COG0515	serine threonine protein kinase
DNK48_RS23005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DNK48_RS23045	COG0531	amino acid
DNK48_RS23070	COG0546	phosphoglycolate phosphatase activity
DNK48_RS23100	COG0725	ABC transporter, periplasmic molybdate-binding protein
DNK48_RS23130	COG2205	protein histidine kinase activity
DNK48_RS23170	COG4585	Histidine kinase
DNK48_RS23175	COG2197	response regulator
DNK48_RS23210	COG2018	Roadblock/LC7 domain
DNK48_RS23220	COG3290	protein histidine kinase activity
DNK48_RS23230	COG1793	dna ligase
DNK48_RS23265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNK48_RS23280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DNK48_RS23290	COG2837	iron assimilation
DNK48_RS23310	COG1741	Belongs to the pirin family
DNK48_RS23320	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS23335	COG1362	aminopeptidase activity
DNK48_RS23380	COG0508	dehydrogenase complex catalyzes the overall conversion of
DNK48_RS23385	COG0022	dehydrogenase e1 component
DNK48_RS23410	COG0515	serine threonine protein kinase
DNK48_RS23415	COG0515	serine threonine protein kinase
DNK48_RS23430	COG0604	alcohol dehydrogenase
DNK48_RS23430	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS23430	COG3321	synthase
DNK48_RS23435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DNK48_RS23445	COG0746	molybdenum cofactor guanylyltransferase activity
DNK48_RS23465	COG1522	sequence-specific DNA binding
DNK48_RS23470	COG1309	transcriptional regulator
DNK48_RS23475	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS23500	COG3396	Phenylacetate-CoA oxygenase
DNK48_RS23505	COG3460	Phenylacetate-CoA oxygenase
DNK48_RS23510	COG3396	Phenylacetate-CoA oxygenase
DNK48_RS23515	COG2151	metal-sulfur cluster biosynthetic enzyme
DNK48_RS23520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DNK48_RS23545	COG1733	regulation of RNA biosynthetic process
DNK48_RS23550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DNK48_RS23560	COG1716	ATPase activity
DNK48_RS23565	COG1716	ATPase activity
DNK48_RS23580	COG0768	penicillin binding
DNK48_RS23585	COG0515	serine threonine protein kinase
DNK48_RS23590	COG3764	Sortase (surface protein transpeptidase)
DNK48_RS23605	COG3764	Sortase (surface protein transpeptidase)
DNK48_RS23620	COG0705	Rhomboid family
DNK48_RS23650	COG0515	serine threonine protein kinase
DNK48_RS23675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DNK48_RS23680	COG0187	DNA topoisomerase II activity
DNK48_RS23685	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DNK48_RS23690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DNK48_RS23695	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DNK48_RS23700	COG0592	DNA-directed DNA polymerase activity
DNK48_RS23715	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DNK48_RS23720	COG0594	ribonuclease P activity
DNK48_RS23725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DNK48_RS23730	COG0706	membrane insertase activity
DNK48_RS23740	COG0357	Ribosomal RNA small subunit methyltransferase G
DNK48_RS23745	COG1192	Involved in chromosome partitioning
DNK48_RS23760	COG3118	belongs to the thioredoxin family
DNK48_RS23765	COG0492	ferredoxin-NADP+ reductase activity
DNK48_RS23775	COG1595	DNA-templated transcription, initiation
DNK48_RS23780	COG2815	serine threonine protein kinase
DNK48_RS23780	COG0515	serine threonine protein kinase
DNK48_RS23795	COG0617	tRNA 3'-terminal CCA addition
DNK48_RS23805	COG1260	myo-inositol-1-phosphate synthase
DNK48_RS23815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNK48_RS23840	COG0360	Binds together with S18 to 16S ribosomal RNA
DNK48_RS23845	COG0629	single-stranded DNA binding
DNK48_RS23850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DNK48_RS23855	COG0359	binds to the 23S rRNA
DNK48_RS23865	COG0305	Participates in initiation and elongation during chromosome replication
DNK48_RS23870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DNK48_RS23875	COG0242	peptide deformylase activity
DNK48_RS23940	COG0626	cystathionine gamma-synthase activity
DNK48_RS23945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DNK48_RS23950	COG1950	PFAM Membrane protein of
DNK48_RS23955	COG0662	Cupin 2, conserved barrel domain protein
DNK48_RS23975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DNK48_RS23995	COG1609	Transcriptional regulator
DNK48_RS24000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNK48_RS24005	COG1271	oxidase subunit
DNK48_RS24010	COG1294	oxidase, subunit
DNK48_RS24030	COG0561	phosphatase activity
DNK48_RS24040	COG0501	Belongs to the peptidase M48B family
DNK48_RS24050	COG1131	(ABC) transporter
DNK48_RS24070	COG2807	transmembrane transport
DNK48_RS24100	COG0561	phosphatase activity
DNK48_RS24105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DNK48_RS24110	COG0077	Prephenate dehydratase
DNK48_RS24115	COG2837	iron assimilation
DNK48_RS24120	COG2372	response to copper ion
DNK48_RS24130	COG1999	signal sequence binding
DNK48_RS24155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNK48_RS24160	COG0006	proline dipeptidase activity
DNK48_RS24175	COG0653	protein targeting
DNK48_RS24240	COG1595	DNA-templated transcription, initiation
DNK48_RS24245	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS24310	COG0745	RESPONSE REGULATOR receiver
DNK48_RS24315	COG2205	protein histidine kinase activity
DNK48_RS24325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DNK48_RS24330	COG0477	Major facilitator Superfamily
DNK48_RS24365	COG1191	sigma factor activity
DNK48_RS24370	COG1191	sigma factor activity
DNK48_RS24375	COG0205	6-phosphofructokinase activity
DNK48_RS24405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DNK48_RS24425	COG0702	epimerase
DNK48_RS24430	COG2124	cytochrome p450
DNK48_RS24485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DNK48_RS24500	COG2197	response regulator
DNK48_RS24505	COG4585	Histidine kinase
DNK48_RS24565	COG2188	Transcriptional regulator
DNK48_RS24655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DNK48_RS24660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DNK48_RS24705	COG2124	cytochrome p450
DNK48_RS24755	COG1408	metallophosphoesterase
DNK48_RS24765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNK48_RS24780	COG0003	Pfam Anion-transporting ATPase
DNK48_RS24805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DNK48_RS24835	COG2267	carboxylic ester hydrolase activity
DNK48_RS24845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DNK48_RS24850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS24915	COG1366	Belongs to the anti-sigma-factor antagonist family
DNK48_RS24920	COG2172	sigma factor antagonist activity
DNK48_RS24930	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DNK48_RS24940	COG2890	protein-(glutamine-N5) methyltransferase activity
DNK48_RS24950	COG1754	DNA topoisomerase type I activity
DNK48_RS24950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DNK48_RS24960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DNK48_RS24990	COG0270	DNA (cytosine-5-)-methyltransferase activity
DNK48_RS25025	COG3573	Dehydrogenase
DNK48_RS25030	COG0129	dihydroxy-acid dehydratase activity
DNK48_RS25035	COG2271	Major facilitator Superfamily
DNK48_RS25045	COG0066	3-isopropylmalate dehydratase activity
DNK48_RS25050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DNK48_RS25055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DNK48_RS25060	COG0066	3-isopropylmalate dehydratase activity
DNK48_RS25065	COG2423	ornithine cyclodeaminase activity
DNK48_RS25075	COG0006	proline dipeptidase activity
DNK48_RS25080	COG2271	Major facilitator Superfamily
DNK48_RS25095	COG0640	Transcriptional regulator
DNK48_RS25105	COG1191	sigma factor activity
DNK48_RS25130	COG4585	Histidine kinase
DNK48_RS25135	COG2197	response regulator
DNK48_RS25140	COG0671	phosphoesterase, PA-phosphatase related
DNK48_RS25195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DNK48_RS25210	COG1595	DNA-templated transcription, initiation
DNK48_RS25225	COG1077	Cell shape determining protein MreB Mrl
DNK48_RS25230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNK48_RS25230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNK48_RS25255	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS25260	COG2318	DinB family
DNK48_RS25285	COG0076	glutamate decarboxylase activity
DNK48_RS25295	COG0789	Transcriptional regulator
DNK48_RS25300	COG0586	Pfam SNARE associated Golgi protein
DNK48_RS25310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DNK48_RS25315	COG2027	D-alanyl-D-alanine carboxypeptidase
DNK48_RS25340	COG0302	gtp cyclohydrolase
DNK48_RS25350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DNK48_RS25355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DNK48_RS25385	COG1174	glycine betaine transport
DNK48_RS25390	COG1174	glycine betaine transport
DNK48_RS25405	COG0649	NAD binding
DNK48_RS25420	COG2197	response regulator
DNK48_RS25445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DNK48_RS25450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DNK48_RS25460	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DNK48_RS25475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DNK48_RS25535	COG1733	regulation of RNA biosynthetic process
DNK48_RS25540	COG1024	Enoyl-CoA hydratase
DNK48_RS25555	COG0737	Belongs to the 5'-nucleotidase family
DNK48_RS25560	COG4804	nuclease activity
DNK48_RS25565	COG0456	acetyltransferase
DNK48_RS25565	COG0454	-acetyltransferase
DNK48_RS25575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DNK48_RS25585	COG0406	alpha-ribazole phosphatase activity
DNK48_RS25585	COG0494	nUDIX hydrolase
DNK48_RS25590	COG1126	abc transporter atp-binding protein
DNK48_RS25605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DNK48_RS25620	COG0667	Aldo Keto reductase
DNK48_RS25640	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS25675	COG0588	phosphoglycerate mutase activity
DNK48_RS25710	COG0640	Transcriptional regulator
DNK48_RS25720	COG2188	Transcriptional regulator
DNK48_RS25725	COG1216	Glycosyl transferase, family 2
DNK48_RS25725	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS25740	COG2319	Wd-40 repeat
DNK48_RS25740	COG4249	Peptidase C14 caspase catalytic subunit p20
DNK48_RS25755	COG5002	protein histidine kinase activity
DNK48_RS25775	COG1329	Transcriptional regulator
DNK48_RS25780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DNK48_RS25785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DNK48_RS25790	COG0215	cysteine-tRNA ligase activity
DNK48_RS25795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DNK48_RS25815	COG3842	ATPase activity
DNK48_RS25865	COG1064	alcohol dehydrogenase
DNK48_RS25870	COG1309	transcriptional regulator
DNK48_RS25885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DNK48_RS25890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNK48_RS25910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DNK48_RS25915	COG1940	carbohydrate kinase activity
DNK48_RS25930	COG1877	trehalose-phosphatase activity
DNK48_RS25930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNK48_RS25940	COG0463	Glycosyl transferase, family 2
DNK48_RS25955	COG1278	Cold shock
DNK48_RS25960	COG0459	protein refolding
DNK48_RS25965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DNK48_RS25970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DNK48_RS25985	COG2197	response regulator
DNK48_RS25990	COG3851	Histidine kinase
DNK48_RS26000	COG0475	glutathione-regulated potassium exporter activity
DNK48_RS26030	COG3142	Participates in the control of copper homeostasis
DNK48_RS26035	COG3973	AAA domain
DNK48_RS26040	COG1061	Type III restriction enzyme res subunit
DNK48_RS26070	COG1120	ATPase activity
DNK48_RS26075	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS26080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS26095	COG1278	Cold shock
DNK48_RS26100	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DNK48_RS26105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DNK48_RS26115	COG2814	Major facilitator Superfamily
DNK48_RS26145	COG2252	PERMEase
DNK48_RS26165	COG0667	Aldo Keto reductase
DNK48_RS26180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DNK48_RS26210	COG2442	InterPro IPR007367
DNK48_RS26245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DNK48_RS26280	COG0259	pyridoxamine-phosphate oxidase activity
DNK48_RS26290	COG4821	SIS domain
DNK48_RS26300	COG0596	Alpha beta hydrolase
DNK48_RS26300	COG2945	thiolester hydrolase activity
DNK48_RS26380	COG1366	Belongs to the anti-sigma-factor antagonist family
DNK48_RS26385	COG3851	Histidine kinase
DNK48_RS26390	COG2197	response regulator
DNK48_RS26410	COG0515	serine threonine protein kinase
DNK48_RS26415	COG0515	serine threonine protein kinase
DNK48_RS26420	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS26440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DNK48_RS26440	COG0519	Catalyzes the synthesis of GMP from XMP
DNK48_RS26465	COG0515	serine threonine protein kinase
DNK48_RS26485	COG2197	response regulator
DNK48_RS26505	COG0460	homoserine dehydrogenase
DNK48_RS26535	COG0739	heme binding
DNK48_RS26545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS26560	COG0714	Associated with various cellular activities
DNK48_RS26585	COG0045	succinate-CoA ligase (ADP-forming) activity
DNK48_RS26610	COG0138	bifunctional purine biosynthesis protein purh
DNK48_RS26615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DNK48_RS26630	COG0039	L-malate dehydrogenase activity
DNK48_RS26655	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS26665	COG4175	Glycine betaine
DNK48_RS26665	COG0517	IMP dehydrogenase activity
DNK48_RS26670	COG4176	ABC-type proline glycine betaine transport system permease component
DNK48_RS26685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNK48_RS26690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DNK48_RS26695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DNK48_RS26710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DNK48_RS26715	COG1595	DNA-templated transcription, initiation
DNK48_RS26720	COG0180	Tryptophanyl-tRNA synthetase
DNK48_RS26750	COG1295	ribonuclease BN
DNK48_RS26755	COG1686	Belongs to the peptidase S11 family
DNK48_RS26760	COG1408	metallophosphoesterase
DNK48_RS26770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DNK48_RS26775	COG1053	succinate dehydrogenase
DNK48_RS26785	COG2009	succinate dehydrogenase
DNK48_RS26820	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS26820	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS26860	COG1316	TRANSCRIPTIONal
DNK48_RS26870	COG2186	Transcriptional regulator
DNK48_RS26875	COG3265	gluconokinase activity
DNK48_RS26885	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS26890	COG1063	alcohol dehydrogenase
DNK48_RS26900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DNK48_RS26910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DNK48_RS26920	COG1216	Glycosyl transferase, family 2
DNK48_RS26930	COG1083	cytidylyl-transferase
DNK48_RS26935	COG2089	acid synthase
DNK48_RS26945	COG1473	amidohydrolase
DNK48_RS26945	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DNK48_RS26955	COG1744	ABC transporter substrate-binding protein PnrA-like
DNK48_RS26960	COG3845	ABC transporter
DNK48_RS26965	COG4603	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS26970	COG1079	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS26990	COG2814	Major facilitator Superfamily
DNK48_RS27000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DNK48_RS27025	COG2205	protein histidine kinase activity
DNK48_RS27030	COG0745	RESPONSE REGULATOR receiver
DNK48_RS27035	COG1595	DNA-templated transcription, initiation
DNK48_RS27045	COG2814	Major facilitator Superfamily
DNK48_RS27045	COG0477	Major facilitator Superfamily
DNK48_RS27055	COG2159	amidohydrolase
DNK48_RS27060	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS27065	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS27080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNK48_RS27125	COG0424	maF-like protein
DNK48_RS27135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DNK48_RS27145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DNK48_RS27155	COG1024	Enoyl-CoA hydratase
DNK48_RS27165	COG2986	histidine ammonia-lyase
DNK48_RS27215	COG3033	Beta-eliminating lyase
DNK48_RS27250	COG2124	cytochrome p450
DNK48_RS27255	COG1652	LysM domain
DNK48_RS27265	COG0148	phosphopyruvate hydratase activity
DNK48_RS27285	COG1252	NADH dehydrogenase
DNK48_RS27295	COG0577	efflux transmembrane transporter activity
DNK48_RS27300	COG1136	(ABC) transporter
DNK48_RS27330	COG0183	Belongs to the thiolase family
DNK48_RS27335	COG2755	lipolytic protein G-D-S-L family
DNK48_RS27350	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS27370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DNK48_RS27385	COG1174	glycine betaine transport
DNK48_RS27410	COG0019	diaminopimelate decarboxylase activity
DNK48_RS27425	COG0604	alcohol dehydrogenase
DNK48_RS27430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DNK48_RS27435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNK48_RS27445	COG1228	amidohydrolase
DNK48_RS27450	COG1191	sigma factor activity
DNK48_RS27455	COG1366	Belongs to the anti-sigma-factor antagonist family
DNK48_RS27485	COG3104	oligopeptide transport
DNK48_RS27490	COG0745	RESPONSE REGULATOR receiver
DNK48_RS27495	COG2205	protein histidine kinase activity
DNK48_RS27520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DNK48_RS27530	COG1316	TRANSCRIPTIONal
DNK48_RS27535	COG1607	acyl-coa hydrolase
DNK48_RS27540	COG1316	TRANSCRIPTIONal
DNK48_RS27555	COG1316	TRANSCRIPTIONal
DNK48_RS27560	COG1316	TRANSCRIPTIONal
DNK48_RS27590	COG0778	Nitroreductase
DNK48_RS27590	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DNK48_RS27595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DNK48_RS27630	COG1620	l-lactate permease
DNK48_RS27635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNK48_RS27640	COG2835	tetraacyldisaccharide 4'-kinase activity
DNK48_RS27650	COG1482	cell wall glycoprotein biosynthetic process
DNK48_RS27660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNK48_RS27660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNK48_RS27660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNK48_RS27665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DNK48_RS27700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DNK48_RS27705	COG0582	viral genome integration into host DNA
DNK48_RS27785	COG2188	Transcriptional regulator
DNK48_RS27795	COG0745	RESPONSE REGULATOR receiver
DNK48_RS27800	COG5002	protein histidine kinase activity
DNK48_RS27805	COG0823	Involved in the tonB-independent uptake of proteins
DNK48_RS27815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DNK48_RS27820	COG2197	response regulator
DNK48_RS27825	COG3214	Protein conserved in bacteria
DNK48_RS27835	COG0653	protein targeting
DNK48_RS27855	COG0693	protein deglycase activity
DNK48_RS27860	COG2902	Dehydrogenase
DNK48_RS27865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNK48_RS27865	COG0463	Glycosyl transferase, family 2
DNK48_RS27895	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS27900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNK48_RS27900	COG0463	Glycosyl transferase, family 2
DNK48_RS27905	COG0395	ABC-type sugar transport system, permease component
DNK48_RS27910	COG1175	transmembrane transport
DNK48_RS27915	COG1653	transport
DNK48_RS27940	COG0515	serine threonine protein kinase
DNK48_RS27950	COG0515	serine threonine protein kinase
DNK48_RS27955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DNK48_RS27970	COG2884	Cell division ATP-binding protein ftsE
DNK48_RS27980	COG0793	Belongs to the peptidase S41A family
DNK48_RS27985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DNK48_RS28020	COG0604	alcohol dehydrogenase
DNK48_RS28035	COG2027	D-alanyl-D-alanine carboxypeptidase
DNK48_RS28040	COG1501	Belongs to the glycosyl hydrolase 31 family
DNK48_RS28045	COG0395	ABC-type sugar transport system, permease component
DNK48_RS28060	COG0583	DNA-binding transcription factor activity
DNK48_RS28070	COG0583	DNA-binding transcription factor activity
DNK48_RS28085	COG2223	nitrite transmembrane transporter activity
DNK48_RS28110	COG3973	AAA domain
DNK48_RS28115	COG1278	Cold shock
DNK48_RS28130	COG0776	regulation of translation
DNK48_RS28135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DNK48_RS28140	COG1678	Uncharacterized ACR, COG1678
DNK48_RS28160	COG1175	transmembrane transport
DNK48_RS28165	COG0395	ABC-type sugar transport system, permease component
DNK48_RS28170	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DNK48_RS28190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS28205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS28210	COG0546	phosphoglycolate phosphatase activity
DNK48_RS28310	COG0583	DNA-binding transcription factor activity
DNK48_RS28320	COG2855	membrane
DNK48_RS28335	COG3654	unkown
DNK48_RS28375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DNK48_RS28385	COG0277	FAD linked oxidase domain protein
DNK48_RS28390	COG1064	alcohol dehydrogenase
DNK48_RS28425	COG1335	isochorismatase
DNK48_RS28435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DNK48_RS28445	COG1113	amino acid transport
DNK48_RS28465	COG1234	tRNA 3'-trailer cleavage
DNK48_RS28475	COG2274	protein secretion by the type I secretion system
DNK48_RS28480	COG1263	PTS System
DNK48_RS28485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNK48_RS28490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DNK48_RS28500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DNK48_RS28520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DNK48_RS28525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNK48_RS28555	COG2733	membrane
DNK48_RS28560	COG3764	Sortase (surface protein transpeptidase)
DNK48_RS28580	COG4702	Belongs to the UPF0303 family
DNK48_RS28585	COG0673	inositol 2-dehydrogenase activity
DNK48_RS28630	COG4585	Histidine kinase
DNK48_RS28635	COG2197	response regulator
DNK48_RS28650	COG2186	Transcriptional regulator
DNK48_RS28685	COG3397	chitin binding
DNK48_RS28720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS28725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DNK48_RS28740	COG1063	alcohol dehydrogenase
DNK48_RS28745	COG0477	Major facilitator Superfamily
DNK48_RS28755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS28760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS28765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS28780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS28790	COG0300	oxidoreductase activity
DNK48_RS28810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS28815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DNK48_RS28820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS28830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNK48_RS28835	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS28850	COG4770	biotin carboxylase activity
DNK48_RS28865	COG2267	carboxylic ester hydrolase activity
DNK48_RS28885	COG1126	abc transporter atp-binding protein
DNK48_RS28890	COG0765	amino acid transport
DNK48_RS28895	COG0765	amino acid transport
DNK48_RS28900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNK48_RS28910	COG0154	amidase activity
DNK48_RS28925	COG3473	Maleate cis-trans isomerase
DNK48_RS28945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS28960	COG2197	response regulator
DNK48_RS28965	COG4585	Histidine kinase
DNK48_RS28990	COG4977	sequence-specific DNA binding
DNK48_RS29080	COG3979	chitinase
DNK48_RS29085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DNK48_RS29115	COG5297	Belongs to the glycosyl hydrolase family 6
DNK48_RS29125	COG5297	Belongs to the glycosyl hydrolase family 6
DNK48_RS29125	COG4733	cellulase activity
DNK48_RS29145	COG0789	Transcriptional regulator
DNK48_RS29150	COG1309	transcriptional regulator
DNK48_RS29190	COG3344	reverse transcriptase
DNK48_RS29260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DNK48_RS29265	COG4977	sequence-specific DNA binding
DNK48_RS29275	COG0589	response to stress
DNK48_RS29280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DNK48_RS29300	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS29320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DNK48_RS29335	COG1946	Acyl-CoA thioesterase
DNK48_RS29345	COG0513	Belongs to the DEAD box helicase family
DNK48_RS29350	COG1278	Cold shock
DNK48_RS29365	COG0640	Transcriptional regulator
DNK48_RS29385	COG4585	Histidine kinase
DNK48_RS29390	COG2197	response regulator
DNK48_RS29415	COG1472	Belongs to the glycosyl hydrolase 3 family
DNK48_RS29450	COG0456	acetyltransferase
DNK48_RS29450	COG0454	-acetyltransferase
DNK48_RS29465	COG1609	Transcriptional regulator
DNK48_RS29490	COG1175	transmembrane transport
DNK48_RS29495	COG0395	ABC-type sugar transport system, permease component
DNK48_RS29515	COG0673	inositol 2-dehydrogenase activity
DNK48_RS29530	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS29535	COG0583	DNA-binding transcription factor activity
DNK48_RS29545	COG1869	D-ribose catabolic process
DNK48_RS29550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNK48_RS29555	COG1879	ABC-type sugar transport system periplasmic component
DNK48_RS29560	COG1129	ABC transporter
DNK48_RS29565	COG1609	Transcriptional regulator
DNK48_RS29570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DNK48_RS29595	COG2409	Drug exporters of the RND superfamily
DNK48_RS29605	COG0673	inositol 2-dehydrogenase activity
DNK48_RS29630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNK48_RS29640	COG3718	enzyme involved in inositol metabolism
DNK48_RS29645	COG3962	Belongs to the TPP enzyme family
DNK48_RS29685	COG2197	response regulator
DNK48_RS29690	COG4585	Histidine kinase
DNK48_RS29700	COG3402	PFAM membrane-flanked domain
DNK48_RS29715	COG3321	synthase
DNK48_RS29715	COG0604	alcohol dehydrogenase
DNK48_RS29735	COG3321	synthase
DNK48_RS29735	COG0604	alcohol dehydrogenase
DNK48_RS29745	COG3321	synthase
DNK48_RS29745	COG0604	alcohol dehydrogenase
DNK48_RS29820	COG1215	transferase activity, transferring glycosyl groups
DNK48_RS29825	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS29830	COG1309	transcriptional regulator
DNK48_RS29855	COG1131	(ABC) transporter
DNK48_RS29865	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS29890	COG0583	DNA-binding transcription factor activity
DNK48_RS29895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNK48_RS29900	COG1993	acr, cog1993
DNK48_RS29905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNK48_RS29910	COG0142	geranyltranstransferase activity
DNK48_RS29915	COG3251	PFAM MbtH domain protein
DNK48_RS29930	COG0346	lactoylglutathione lyase activity
DNK48_RS29960	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS29965	COG1309	transcriptional regulator
DNK48_RS29995	COG0629	single-stranded DNA binding
DNK48_RS30030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DNK48_RS30060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNK48_RS30075	COG1486	melibiose metabolic process
DNK48_RS30080	COG0395	ABC-type sugar transport system, permease component
DNK48_RS30085	COG1175	transmembrane transport
DNK48_RS30090	COG1653	transport
DNK48_RS30095	COG1846	Transcriptional regulator
DNK48_RS30095	COG1940	carbohydrate kinase activity
DNK48_RS30105	COG0668	transmembrane transport
DNK48_RS30115	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DNK48_RS30115	COG3291	Pkd domain containing protein
DNK48_RS30180	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DNK48_RS30190	COG1113	amino acid transport
DNK48_RS30205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DNK48_RS30235	COG1113	amino acid transport
DNK48_RS30240	COG0698	ribose 5-phosphate isomerase
DNK48_RS30250	COG4552	Acetyltransferase involved in intracellular survival and related
DNK48_RS30270	COG3594	Acyltransferase
DNK48_RS30290	COG0544	peptidyl-prolyl cis-trans isomerase activity
DNK48_RS30295	COG0740	serine-type endopeptidase activity
DNK48_RS30300	COG0740	serine-type endopeptidase activity
DNK48_RS30305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DNK48_RS30325	COG0525	valine-tRNA ligase activity
DNK48_RS30330	COG0768	penicillin binding
DNK48_RS30335	COG0285	dihydrofolate synthase activity
DNK48_RS30345	COG0105	UTP biosynthetic process
DNK48_RS30350	COG1077	Cell shape determining protein MreB Mrl
DNK48_RS30365	COG0768	penicillin binding
DNK48_RS30375	COG0772	Belongs to the SEDS family
DNK48_RS30395	COG1530	ribonuclease E activity
DNK48_RS30400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DNK48_RS30405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DNK48_RS30410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DNK48_RS30420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DNK48_RS30430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DNK48_RS30445	COG0501	Belongs to the peptidase M48B family
DNK48_RS30450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DNK48_RS30460	COG0799	negative regulation of ribosome biogenesis
DNK48_RS30465	COG0406	alpha-ribazole phosphatase activity
DNK48_RS30490	COG0495	leucyl-tRNA aminoacylation
DNK48_RS30500	COG1307	EDD domain protein, DegV family
DNK48_RS30505	COG1555	photosystem II stabilization
DNK48_RS30535	COG0268	Binds directly to 16S ribosomal RNA
DNK48_RS30540	COG0481	GTPase activity
DNK48_RS30545	COG1022	Amp-dependent synthetase and ligase
DNK48_RS30570	COG1420	regulation of RNA biosynthetic process
DNK48_RS30575	COG0484	heat shock protein binding
DNK48_RS30595	COG0537	adenosine 5'-monophosphoramidase activity
DNK48_RS30600	COG1234	tRNA 3'-trailer cleavage
DNK48_RS30605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNK48_RS30615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DNK48_RS30635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DNK48_RS30650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DNK48_RS30660	COG2409	Drug exporters of the RND superfamily
DNK48_RS30665	COG4585	Histidine kinase
DNK48_RS30670	COG2197	response regulator
DNK48_RS30675	COG3422	double-strand break repair
DNK48_RS30720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DNK48_RS30740	COG1381	Involved in DNA repair and RecF pathway recombination
DNK48_RS30745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DNK48_RS30755	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS30775	COG0596	Alpha beta hydrolase
DNK48_RS30810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DNK48_RS30815	COG1121	(ABC) transporter
DNK48_RS30825	COG0423	glycine-tRNA ligase activity
DNK48_RS30845	COG2197	response regulator
DNK48_RS30850	COG0477	Major facilitator Superfamily
DNK48_RS30890	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DNK48_RS30895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DNK48_RS30895	COG0574	Belongs to the PEP-utilizing enzyme family
DNK48_RS30925	COG0745	RESPONSE REGULATOR receiver
DNK48_RS30930	COG2205	protein histidine kinase activity
DNK48_RS30940	COG0531	amino acid
DNK48_RS30945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DNK48_RS30950	COG2188	Transcriptional regulator
DNK48_RS30955	COG0395	ABC-type sugar transport system, permease component
DNK48_RS30960	COG1175	transmembrane transport
DNK48_RS30965	COG2182	Extracellular solute-binding protein
DNK48_RS30970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNK48_RS30975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DNK48_RS30980	COG3485	protocatechuate 3,4-dioxygenase
DNK48_RS30985	COG3485	protocatechuate 3,4-dioxygenase
DNK48_RS30990	COG0183	Belongs to the thiolase family
DNK48_RS31000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DNK48_RS31010	COG1846	Transcriptional regulator
DNK48_RS31015	COG2890	protein-(glutamine-N5) methyltransferase activity
DNK48_RS31020	COG0300	oxidoreductase activity
DNK48_RS31030	COG1472	Belongs to the glycosyl hydrolase 3 family
DNK48_RS31040	COG1175	transmembrane transport
DNK48_RS31050	COG1609	Transcriptional regulator
DNK48_RS31060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DNK48_RS31060	COG2146	nitrite reductase [NAD(P)H] activity
DNK48_RS31070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DNK48_RS31075	COG2124	cytochrome p450
DNK48_RS31080	COG2124	cytochrome p450
DNK48_RS31110	COG0745	RESPONSE REGULATOR receiver
DNK48_RS31145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DNK48_RS31150	COG0243	molybdopterin cofactor binding
DNK48_RS31160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DNK48_RS31170	COG0358	DNA primase activity
DNK48_RS31180	COG1070	Carbohydrate kinase
DNK48_RS31240	COG3851	Histidine kinase
DNK48_RS31245	COG2197	response regulator
DNK48_RS31250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DNK48_RS31255	COG0395	ABC-type sugar transport system, permease component
DNK48_RS31260	COG1175	transmembrane transport
DNK48_RS31280	COG1486	melibiose metabolic process
DNK48_RS31290	COG2207	Transcriptional regulator
DNK48_RS31295	COG2080	2 iron, 2 sulfur cluster binding
DNK48_RS31300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DNK48_RS31305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS31340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNK48_RS31345	COG0588	phosphoglycerate mutase activity
DNK48_RS31360	COG1414	Transcriptional regulator
DNK48_RS31365	COG3386	PFAM SMP-30 Gluconolaconase
DNK48_RS31385	COG2130	NADP-dependent
DNK48_RS31420	COG4214	carbohydrate transport
DNK48_RS31425	COG1129	ABC transporter
DNK48_RS31445	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS31490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNK48_RS31495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNK48_RS31500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DNK48_RS31525	COG0789	Transcriptional regulator
DNK48_RS31530	COG0667	Aldo Keto reductase
DNK48_RS31550	COG2197	response regulator
DNK48_RS31555	COG4585	Histidine kinase
DNK48_RS31570	COG1309	transcriptional regulator
DNK48_RS31575	COG0477	Major facilitator Superfamily
DNK48_RS31585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DNK48_RS31675	COG3321	synthase
DNK48_RS31675	COG0604	alcohol dehydrogenase
DNK48_RS31685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DNK48_RS31745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNK48_RS31760	COG4106	trans-aconitate 2-methyltransferase activity
DNK48_RS31765	COG3903	Transcriptional regulator
DNK48_RS31765	COG3629	intracellular signal transduction
DNK48_RS31785	COG1309	transcriptional regulator
DNK48_RS31805	COG0740	serine-type endopeptidase activity
DNK48_RS31810	COG0740	serine-type endopeptidase activity
DNK48_RS31815	COG1396	sequence-specific DNA binding
DNK48_RS31895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNK48_RS31925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DNK48_RS31945	COG5002	protein histidine kinase activity
DNK48_RS31970	COG2207	Transcriptional regulator
DNK48_RS31975	COG0604	alcohol dehydrogenase
DNK48_RS32015	COG0604	alcohol dehydrogenase
DNK48_RS32030	COG2207	Transcriptional regulator
DNK48_RS32050	COG2124	cytochrome p450
DNK48_RS32055	COG0183	Belongs to the thiolase family
DNK48_RS32070	COG3845	ABC transporter
DNK48_RS32115	COG2197	response regulator
DNK48_RS32120	COG1309	transcriptional regulator
DNK48_RS32125	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS32145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS32155	COG0860	N-Acetylmuramoyl-L-alanine amidase
DNK48_RS32160	COG3510	cephalosporin hydroxylase
DNK48_RS32165	COG2030	dehydratase
DNK48_RS32175	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS32185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DNK48_RS32190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DNK48_RS32205	COG0800	Aldolase
DNK48_RS32210	COG3022	response to hydroperoxide
DNK48_RS32225	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS32235	COG2409	Drug exporters of the RND superfamily
DNK48_RS32245	COG2197	response regulator
DNK48_RS32265	COG0473	3-isopropylmalate dehydrogenase activity
DNK48_RS32270	COG0583	DNA-binding transcription factor activity
DNK48_RS32275	COG0596	Alpha beta hydrolase
DNK48_RS32305	COG0542	response to heat
DNK48_RS32320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DNK48_RS32325	COG0443	Heat shock 70 kDa protein
DNK48_RS32360	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS32365	COG3540	Alkaline phosphatase
DNK48_RS32375	COG2814	Major facilitator Superfamily
DNK48_RS32380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DNK48_RS32390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DNK48_RS32415	COG0672	)-iron permease
DNK48_RS32420	COG2837	iron assimilation
DNK48_RS32425	COG2822	iron ion transport
DNK48_RS32430	COG1120	ATPase activity
DNK48_RS32435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS32440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DNK48_RS32495	COG0113	porphobilinogen synthase activity
DNK48_RS32500	COG0181	hydroxymethylbilane synthase activity
DNK48_RS32525	COG1175	transmembrane transport
DNK48_RS32530	COG0395	ABC-type sugar transport system, permease component
DNK48_RS32545	COG1994	Peptidase M50
DNK48_RS32570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DNK48_RS32575	COG0477	Major facilitator Superfamily
DNK48_RS32580	COG1309	transcriptional regulator
DNK48_RS32590	COG2814	Major facilitator Superfamily
DNK48_RS32595	COG2267	carboxylic ester hydrolase activity
DNK48_RS32600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DNK48_RS32600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DNK48_RS32605	COG2132	Multicopper oxidase
DNK48_RS32610	COG0174	glutamine synthetase
DNK48_RS32620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DNK48_RS32645	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DNK48_RS32655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DNK48_RS32660	COG0561	phosphatase activity
DNK48_RS32675	COG0366	Alpha amylase catalytic
DNK48_RS32680	COG2182	Extracellular solute-binding protein
DNK48_RS32690	COG3833	ABC-type maltose transport systems, permease component
DNK48_RS32720	COG2197	response regulator
DNK48_RS32740	COG0745	RESPONSE REGULATOR receiver
DNK48_RS32755	COG0477	Major facilitator Superfamily
DNK48_RS32785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DNK48_RS32795	COG1280	lysine exporter protein (LysE YggA)
DNK48_RS32815	COG0174	glutamine synthetase
DNK48_RS32835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DNK48_RS32840	COG0321	lipoyl(octanoyl) transferase activity
DNK48_RS32850	COG0640	Transcriptional regulator
DNK48_RS32875	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS32885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DNK48_RS32900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNK48_RS32905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DNK48_RS32910	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DNK48_RS32915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DNK48_RS32950	COG4585	Histidine kinase
DNK48_RS32955	COG2197	response regulator
DNK48_RS32960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DNK48_RS32980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNK48_RS32990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DNK48_RS32995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DNK48_RS33005	COG1376	ErfK ybiS ycfS ynhG family protein
DNK48_RS33015	COG1845	cytochrome c oxidase, subunit III
DNK48_RS33020	COG2010	Cytochrome c
DNK48_RS33025	COG0723	plastoquinol--plastocyanin reductase activity
DNK48_RS33030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DNK48_RS33035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DNK48_RS33040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DNK48_RS33110	COG1940	carbohydrate kinase activity
DNK48_RS33145	COG0205	6-phosphofructokinase activity
DNK48_RS33160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DNK48_RS33165	COG0243	molybdopterin cofactor binding
DNK48_RS33170	COG2193	ferroxidase activity
DNK48_RS33175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DNK48_RS33185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DNK48_RS33195	COG2815	serine threonine protein kinase
DNK48_RS33195	COG0515	serine threonine protein kinase
DNK48_RS33215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNK48_RS33215	COG2022	thiamine diphosphate biosynthetic process
DNK48_RS33230	COG0352	thiamine-phosphate diphosphorylase activity
DNK48_RS33245	COG1233	COG1233 Phytoene dehydrogenase and related
DNK48_RS33250	COG1309	transcriptional regulator
DNK48_RS33260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DNK48_RS33290	COG0714	Associated with various cellular activities
DNK48_RS33300	COG0275	rRNA processing
DNK48_RS33315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DNK48_RS33325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DNK48_RS33330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DNK48_RS33340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DNK48_RS33345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DNK48_RS33350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DNK48_RS33355	COG1496	oxidoreductase activity
DNK48_RS33365	COG1799	cell septum assembly
DNK48_RS33380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DNK48_RS33395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DNK48_RS33440	COG0587	DNA-directed DNA polymerase activity
DNK48_RS33450	COG1432	Conserved Protein
DNK48_RS33470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DNK48_RS33475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DNK48_RS33485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DNK48_RS33490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNK48_RS33495	COG0131	Imidazoleglycerol-phosphate dehydratase
DNK48_RS33500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DNK48_RS33505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DNK48_RS33510	COG0251	oxidation-reduction process
DNK48_RS33515	COG0107	imidazoleglycerol-phosphate synthase activity
DNK48_RS33520	COG4221	oxidoreductase activity
DNK48_RS33535	COG1120	ATPase activity
DNK48_RS33565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DNK48_RS33570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DNK48_RS33590	COG0134	indole-3-glycerol-phosphate synthase activity
DNK48_RS33595	COG0133	tryptophan synthase activity
DNK48_RS33600	COG0159	tryptophan synthase activity
DNK48_RS33610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DNK48_RS33620	COG0070	glutamate synthase
DNK48_RS33620	COG0067	glutamate synthase
DNK48_RS33620	COG0069	glutamate synthase activity
DNK48_RS33630	COG1725	Transcriptional regulator
DNK48_RS33635	COG1131	(ABC) transporter
DNK48_RS33650	COG3467	pyridoxamine 5'-phosphate
DNK48_RS33670	COG1605	Chorismate mutase
DNK48_RS33670	COG0287	Prephenate dehydrogenase
DNK48_RS33695	COG0737	Belongs to the 5'-nucleotidase family
DNK48_RS33700	COG0494	nUDIX hydrolase
DNK48_RS33735	COG0411	ABC transporter
DNK48_RS33760	COG2050	protein possibly involved in aromatic compounds catabolism
DNK48_RS33815	COG2226	methyltransferase
DNK48_RS33825	COG0539	negative regulation of cytoplasmic translation
DNK48_RS33845	COG0237	dephospho-CoA kinase activity
DNK48_RS33895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DNK48_RS33900	COG0584	glycerophosphoryl diester phosphodiesterase
DNK48_RS33905	COG0556	nucleotide-excision repair
DNK48_RS33925	COG0477	Major facilitator Superfamily
DNK48_RS33940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNK48_RS33950	COG1609	Transcriptional regulator
DNK48_RS33960	COG0322	excinuclease ABC activity
DNK48_RS33965	COG1660	Displays ATPase and GTPase activities
DNK48_RS33970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DNK48_RS33975	COG1481	regulation of sporulation
DNK48_RS33985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DNK48_RS33990	COG0126	phosphoglycerate kinase activity
DNK48_RS33995	COG0149	triose-phosphate isomerase activity
DNK48_RS34000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DNK48_RS34015	COG0166	Belongs to the GPI family
DNK48_RS34035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DNK48_RS34040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DNK48_RS34045	COG0109	protoheme IX farnesyltransferase activity
DNK48_RS34065	COG1612	heme a metabolic process
DNK48_RS34090	COG0719	Fe-S assembly protein
DNK48_RS34100	COG0396	ATPase activity
DNK48_RS34105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DNK48_RS34110	COG0822	iron-sulfur transferase activity
DNK48_RS34115	COG2151	metal-sulfur cluster biosynthetic enzyme
DNK48_RS34120	COG2076	Multidrug Resistance protein
DNK48_RS34125	COG3226	Transcriptional regulator
DNK48_RS34130	COG2171	N-acyltransferase activity
DNK48_RS34165	COG1090	epimerase
DNK48_RS34185	COG0477	Major facilitator Superfamily
DNK48_RS34190	COG1335	isochorismatase
DNK48_RS34195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNK48_RS34200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNK48_RS34220	COG1802	Transcriptional regulator
DNK48_RS34225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNK48_RS34240	COG0395	ABC-type sugar transport system, permease component
DNK48_RS34270	COG2252	PERMEase
DNK48_RS34275	COG0667	Aldo Keto reductase
DNK48_RS34285	COG4585	Histidine kinase
DNK48_RS34295	COG1414	Transcriptional regulator
DNK48_RS34305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DNK48_RS34310	COG5285	phytanoyl-CoA dioxygenase
DNK48_RS34315	COG1917	Cupin 2, conserved barrel domain protein
DNK48_RS34325	COG0456	acetyltransferase
DNK48_RS34370	COG1797	cobyrinic acid a,c-diamide synthase activity
DNK48_RS34385	COG1492	cobalamin metabolic process
DNK48_RS34405	COG0235	Class ii aldolase
DNK48_RS34420	COG0488	(ABC) transporter
DNK48_RS34440	COG4999	Histidine kinase
DNK48_RS34440	COG3437	response regulator, receiver
DNK48_RS34440	COG2205	protein histidine kinase activity
DNK48_RS34440	COG3850	Histidine kinase
DNK48_RS34480	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS34485	COG3387	PFAM Glycoside hydrolase 15-related
DNK48_RS34500	COG2176	DNA-directed DNA polymerase activity
DNK48_RS34535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNK48_RS34540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DNK48_RS34560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DNK48_RS34625	COG1902	pentaerythritol trinitrate reductase activity
DNK48_RS34630	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS34635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DNK48_RS34645	COG2186	Transcriptional regulator
DNK48_RS34650	COG2807	transmembrane transport
DNK48_RS34665	COG0560	Phosphoserine phosphatase
DNK48_RS34665	COG3830	Belongs to the UPF0237 family
DNK48_RS34675	COG0842	Transport permease protein
DNK48_RS34675	COG1131	(ABC) transporter
DNK48_RS34675	COG1716	ATPase activity
DNK48_RS34680	COG3953	SLT domain
DNK48_RS34680	COG5280	Phage tail tape measure protein TP901
DNK48_RS34685	COG4585	Histidine kinase
DNK48_RS34690	COG2197	response regulator
DNK48_RS34705	COG1119	ATPase activity
DNK48_RS34725	COG1881	PFAM PEBP family protein
DNK48_RS34740	COG2094	Belongs to the DNA glycosylase MPG family
DNK48_RS34780	COG0647	UMP catabolic process
DNK48_RS34785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS34790	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS34795	COG1120	ATPase activity
DNK48_RS34820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DNK48_RS34825	COG0497	DNA recombination
DNK48_RS34830	COG0297	glycogen (starch) synthase activity
DNK48_RS34845	COG3387	PFAM Glycoside hydrolase 15-related
DNK48_RS34850	COG0504	CTP synthase activity
DNK48_RS34855	COG0494	nUDIX hydrolase
DNK48_RS34860	COG3629	intracellular signal transduction
DNK48_RS34860	COG3903	Transcriptional regulator
DNK48_RS34865	COG0686	Belongs to the AlaDH PNT family
DNK48_RS34880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DNK48_RS34885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DNK48_RS34890	COG1187	pseudouridine synthase activity
DNK48_RS34905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DNK48_RS34915	COG1160	GTP binding
DNK48_RS34930	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS34945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DNK48_RS34995	COG0671	phosphoesterase, PA-phosphatase related
DNK48_RS35015	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS35020	COG1799	cell septum assembly
DNK48_RS35040	COG1126	abc transporter atp-binding protein
DNK48_RS35045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNK48_RS35055	COG0330	HflC and HflK could
DNK48_RS35070	COG3467	pyridoxamine 5'-phosphate
DNK48_RS35075	COG0587	DNA-directed DNA polymerase activity
DNK48_RS35080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNK48_RS35090	COG1764	response to oxidative stress
DNK48_RS35095	COG1846	Transcriptional regulator
DNK48_RS35125	COG0019	diaminopimelate decarboxylase activity
DNK48_RS35150	COG0519	Catalyzes the synthesis of GMP from XMP
DNK48_RS35150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DNK48_RS35185	COG2124	cytochrome p450
DNK48_RS35190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DNK48_RS35190	COG2226	methyltransferase
DNK48_RS35190	COG0596	Alpha beta hydrolase
DNK48_RS35200	COG2226	methyltransferase
DNK48_RS35220	COG1834	amidinotransferase
DNK48_RS35240	COG1649	PFAM Uncharacterised BCR, COG1649
DNK48_RS35240	COG0726	polysaccharide deacetylase
DNK48_RS35255	COG0463	Glycosyl transferase, family 2
DNK48_RS35270	COG2755	lipolytic protein G-D-S-L family
DNK48_RS35275	COG0515	serine threonine protein kinase
DNK48_RS35305	COG2188	Transcriptional regulator
DNK48_RS35310	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DNK48_RS35315	COG1309	transcriptional regulator
DNK48_RS35320	COG0243	molybdopterin cofactor binding
DNK48_RS35325	COG2851	Citrate transporter
DNK48_RS35350	COG2409	Drug exporters of the RND superfamily
DNK48_RS35355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DNK48_RS35370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS35385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DNK48_RS35390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DNK48_RS35395	COG0142	geranyltranstransferase activity
DNK48_RS35400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DNK48_RS35405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DNK48_RS35450	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS35470	COG1733	regulation of RNA biosynthetic process
DNK48_RS35485	COG2149	membrane
DNK48_RS35490	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DNK48_RS35550	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS35570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS35575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DNK48_RS35580	COG2080	2 iron, 2 sulfur cluster binding
DNK48_RS35585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNK48_RS35605	COG0297	glycogen (starch) synthase activity
DNK48_RS35625	COG4221	oxidoreductase activity
DNK48_RS35645	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DNK48_RS35650	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DNK48_RS35655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DNK48_RS35685	COG0515	serine threonine protein kinase
DNK48_RS35685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DNK48_RS35690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DNK48_RS35720	COG1074	ATP-dependent DNA helicase activity
DNK48_RS35785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DNK48_RS35795	COG0789	Transcriptional regulator
DNK48_RS35815	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DNK48_RS35830	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS36000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DNK48_RS36035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DNK48_RS36145	COG0667	Aldo Keto reductase
DNK48_RS36150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS36160	COG0598	Magnesium transport protein CorA
DNK48_RS36180	COG0215	cysteine-tRNA ligase activity
DNK48_RS36190	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS36195	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS36205	COG1129	ABC transporter
DNK48_RS36210	COG4211	Belongs to the binding-protein-dependent transport system permease family
DNK48_RS36225	COG2186	Transcriptional regulator
DNK48_RS36235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS36245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS36260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DNK48_RS36265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNK48_RS36270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNK48_RS36275	COG1414	Transcriptional regulator
DNK48_RS36280	COG1410	methionine synthase
DNK48_RS36280	COG0646	methionine synthase
DNK48_RS36285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNK48_RS36295	COG2197	response regulator
DNK48_RS36305	COG0517	IMP dehydrogenase activity
DNK48_RS36305	COG1994	Peptidase M50
DNK48_RS36325	COG1222	aaa ATPase
DNK48_RS36330	COG4122	O-methyltransferase activity
DNK48_RS36340	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DNK48_RS36345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DNK48_RS36360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DNK48_RS36365	COG0545	Peptidyl-prolyl cis-trans isomerase
DNK48_RS36375	COG2378	regulation of single-species biofilm formation
DNK48_RS36395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DNK48_RS36400	COG0805	protein transport
DNK48_RS36430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNK48_RS36435	COG4175	Glycine betaine
DNK48_RS36435	COG0517	IMP dehydrogenase activity
DNK48_RS36455	COG1309	transcriptional regulator
DNK48_RS36470	COG1228	amidohydrolase
DNK48_RS36475	COG2267	carboxylic ester hydrolase activity
DNK48_RS36485	COG3959	Transketolase, thiamine diphosphate binding domain
DNK48_RS36555	COG1472	Belongs to the glycosyl hydrolase 3 family
DNK48_RS36570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DNK48_RS36585	COG0028	Belongs to the TPP enzyme family
DNK48_RS36595	COG0277	FAD linked oxidase domain protein
DNK48_RS36605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DNK48_RS36670	COG0531	amino acid
DNK48_RS36680	COG0604	alcohol dehydrogenase
DNK48_RS36705	COG0604	alcohol dehydrogenase
DNK48_RS36705	COG3321	synthase
DNK48_RS36705	COG0604	alcohol dehydrogenase
DNK48_RS36705	COG3321	synthase
DNK48_RS36735	COG0604	alcohol dehydrogenase
DNK48_RS36735	COG3321	synthase
DNK48_RS36750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DNK48_RS36765	COG0546	phosphoglycolate phosphatase activity
DNK48_RS36775	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS36790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DNK48_RS36805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DNK48_RS36835	COG0583	DNA-binding transcription factor activity
DNK48_RS36875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNK48_RS36885	COG2186	Transcriptional regulator
DNK48_RS36890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS36905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS36905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DNK48_RS36910	COG1620	l-lactate permease
DNK48_RS36920	COG0583	DNA-binding transcription factor activity
DNK48_RS36925	COG0667	Aldo Keto reductase
DNK48_RS36935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS36940	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS36945	COG1309	transcriptional regulator
DNK48_RS36975	COG1022	Amp-dependent synthetase and ligase
DNK48_RS36980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNK48_RS36985	COG1024	Enoyl-CoA hydratase
DNK48_RS36990	COG1024	Enoyl-CoA hydratase
DNK48_RS37015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNK48_RS37035	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS37050	COG2807	transmembrane transport
DNK48_RS37055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DNK48_RS37060	COG4770	biotin carboxylase activity
DNK48_RS37085	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
DNK48_RS37105	COG1408	metallophosphoesterase
DNK48_RS37135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS37140	COG0702	epimerase
DNK48_RS37150	COG2197	response regulator
DNK48_RS37165	COG3321	synthase
DNK48_RS37165	COG0604	alcohol dehydrogenase
DNK48_RS37170	COG3321	synthase
DNK48_RS37170	COG0604	alcohol dehydrogenase
DNK48_RS37175	COG3321	synthase
DNK48_RS37175	COG0604	alcohol dehydrogenase
DNK48_RS37215	COG0477	Major facilitator Superfamily
DNK48_RS37225	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS37250	COG0477	Major facilitator Superfamily
DNK48_RS37275	COG0300	oxidoreductase activity
DNK48_RS37280	COG1082	Xylose isomerase domain protein TIM barrel
DNK48_RS37290	COG2318	DinB family
DNK48_RS37300	COG1396	sequence-specific DNA binding
DNK48_RS37315	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS37325	COG0156	8-amino-7-oxononanoate synthase activity
DNK48_RS37340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DNK48_RS37345	COG1316	TRANSCRIPTIONal
DNK48_RS37355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DNK48_RS37360	COG0640	Transcriptional regulator
DNK48_RS37380	COG0069	glutamate synthase activity
DNK48_RS37390	COG4221	oxidoreductase activity
DNK48_RS37400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS37405	COG1120	ATPase activity
DNK48_RS37440	COG1131	(ABC) transporter
DNK48_RS37440	COG0842	Transport permease protein
DNK48_RS37440	COG1716	ATPase activity
DNK48_RS37445	COG2409	Drug exporters of the RND superfamily
DNK48_RS37450	COG4585	Histidine kinase
DNK48_RS37465	COG2814	Major facilitator Superfamily
DNK48_RS37490	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS37515	COG0145	ligase activity
DNK48_RS37535	COG0346	lactoylglutathione lyase activity
DNK48_RS37540	COG3458	cephalosporin-C deacetylase activity
DNK48_RS37550	COG0300	oxidoreductase activity
DNK48_RS37560	COG1309	transcriptional regulator
DNK48_RS37565	COG1064	alcohol dehydrogenase
DNK48_RS37580	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS37585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNK48_RS37595	COG2188	Transcriptional regulator
DNK48_RS37605	COG1175	transmembrane transport
DNK48_RS37615	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS37630	COG2205	protein histidine kinase activity
DNK48_RS37635	COG0745	RESPONSE REGULATOR receiver
DNK48_RS37640	COG3180	Ammonia monooxygenase
DNK48_RS37650	COG0745	RESPONSE REGULATOR receiver
DNK48_RS37685	COG0730	response to heat
DNK48_RS37690	COG1937	Protein conserved in bacteria
DNK48_RS37695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DNK48_RS37710	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS37720	COG2124	cytochrome p450
DNK48_RS37740	COG0402	S-adenosylhomocysteine deaminase activity
DNK48_RS37760	COG0702	epimerase
DNK48_RS37770	COG1309	transcriptional regulator
DNK48_RS37775	COG0583	DNA-binding transcription factor activity
DNK48_RS37780	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS37810	COG2824	Alkylphosphonate utilization operon protein PhnA
DNK48_RS37830	COG0583	DNA-binding transcription factor activity
DNK48_RS37835	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS37875	COG2197	response regulator
DNK48_RS37880	COG3850	Histidine kinase
DNK48_RS37910	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS37945	COG1233	COG1233 Phytoene dehydrogenase and related
DNK48_RS37970	COG0596	Alpha beta hydrolase
DNK48_RS37980	COG2072	flavoprotein involved in K transport
DNK48_RS38005	COG0583	DNA-binding transcription factor activity
DNK48_RS38020	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS38030	COG0583	DNA-binding transcription factor activity
DNK48_RS38035	COG4977	sequence-specific DNA binding
DNK48_RS38040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DNK48_RS38060	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS38065	COG1968	undecaprenyl-diphosphatase activity
DNK48_RS38090	COG0154	amidase activity
DNK48_RS38095	COG1309	transcriptional regulator
DNK48_RS38100	COG1802	Transcriptional regulator
DNK48_RS38105	COG0436	Aminotransferase
DNK48_RS38205	COG0300	oxidoreductase activity
DNK48_RS38220	COG4941	Belongs to the sigma-70 factor family
DNK48_RS38225	COG3795	YCII-related domain
DNK48_RS38235	COG0588	phosphoglycerate mutase activity
DNK48_RS38240	COG1070	Carbohydrate kinase
DNK48_RS38245	COG1070	Carbohydrate kinase
DNK48_RS38250	COG1349	DNA-binding transcription factor activity
DNK48_RS38260	COG2814	Major facilitator Superfamily
DNK48_RS38265	COG1349	DNA-binding transcription factor activity
DNK48_RS38270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNK48_RS38275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNK48_RS38285	COG2376	Dihydroxyacetone kinase
DNK48_RS38290	COG0698	ribose 5-phosphate isomerase
DNK48_RS38350	COG0673	inositol 2-dehydrogenase activity
DNK48_RS38360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNK48_RS38365	COG4209	transmembrane transport
DNK48_RS38370	COG0395	ABC-type sugar transport system, permease component
DNK48_RS38405	COG3469	chitinase activity
DNK48_RS38445	COG3469	chitinase activity
DNK48_RS38455	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS38470	COG1129	ABC transporter
DNK48_RS38475	COG1802	Transcriptional regulator
DNK48_RS38490	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS38530	COG2197	response regulator
DNK48_RS38565	COG0277	FAD linked oxidase domain protein
DNK48_RS38575	COG1309	transcriptional regulator
DNK48_RS38590	COG1309	transcriptional regulator
DNK48_RS38600	COG2205	protein histidine kinase activity
DNK48_RS38605	COG0745	RESPONSE REGULATOR receiver
DNK48_RS38620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS38625	COG1116	anion transmembrane transporter activity
DNK48_RS38635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS38640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS38665	COG3971	2-oxopent-4-enoate hydratase activity
DNK48_RS38685	COG0515	serine threonine protein kinase
DNK48_RS38705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNK48_RS38710	COG1595	DNA-templated transcription, initiation
DNK48_RS38720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNK48_RS38725	COG1120	ATPase activity
DNK48_RS38730	COG0243	molybdopterin cofactor binding
DNK48_RS38760	COG2267	carboxylic ester hydrolase activity
DNK48_RS38780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS38795	COG0251	oxidation-reduction process
DNK48_RS38810	COG3961	Belongs to the TPP enzyme family
DNK48_RS38815	COG1231	oxidoreductase activity
DNK48_RS38835	COG0583	DNA-binding transcription factor activity
DNK48_RS38845	COG2814	Major facilitator Superfamily
DNK48_RS38855	COG0656	L-ascorbic acid biosynthetic process
DNK48_RS38870	COG1902	pentaerythritol trinitrate reductase activity
DNK48_RS38910	COG2226	methyltransferase
DNK48_RS38930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DNK48_RS38935	COG0395	ABC-type sugar transport system, permease component
DNK48_RS38940	COG1175	transmembrane transport
DNK48_RS38950	COG1414	Transcriptional regulator
DNK48_RS38990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNK48_RS38995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNK48_RS39000	COG2188	Transcriptional regulator
DNK48_RS39010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DNK48_RS39015	COG1131	(ABC) transporter
DNK48_RS39025	COG3850	Histidine kinase
DNK48_RS39050	COG2326	polyphosphate kinase activity
DNK48_RS39055	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DNK48_RS39065	COG3639	organic phosphonate transmembrane transporter activity
DNK48_RS39080	COG3119	arylsulfatase activity
DNK48_RS39085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS39135	COG1116	anion transmembrane transporter activity
DNK48_RS39140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS39150	COG2027	D-alanyl-D-alanine carboxypeptidase
DNK48_RS39170	COG2706	6-phosphogluconolactonase activity
DNK48_RS39190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DNK48_RS39200	COG1902	pentaerythritol trinitrate reductase activity
DNK48_RS39205	COG0640	Transcriptional regulator
DNK48_RS39210	COG2233	PERMEase
DNK48_RS39230	COG1309	transcriptional regulator
DNK48_RS39270	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNK48_RS39280	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS39310	COG0604	alcohol dehydrogenase
DNK48_RS39310	COG3321	synthase
DNK48_RS39325	COG0596	Alpha beta hydrolase
DNK48_RS39340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DNK48_RS39360	COG4166	transmembrane transport
DNK48_RS39365	COG0601	transmembrane transport
DNK48_RS39370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNK48_RS39375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNK48_RS39415	COG2070	2-Nitropropane dioxygenase
DNK48_RS39420	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS39425	COG1024	Enoyl-CoA hydratase
DNK48_RS39435	COG1024	Enoyl-CoA hydratase
DNK48_RS39440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DNK48_RS39445	COG1846	Transcriptional regulator
DNK48_RS39450	COG2271	Major facilitator Superfamily
DNK48_RS39455	COG0671	phosphoesterase, PA-phosphatase related
DNK48_RS39530	COG1309	transcriptional regulator
DNK48_RS39570	COG0584	glycerophosphoryl diester phosphodiesterase
DNK48_RS39610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DNK48_RS39660	COG3345	alpha-galactosidase
DNK48_RS39670	COG1175	transmembrane transport
DNK48_RS39675	COG0395	ABC-type sugar transport system, permease component
DNK48_RS39680	COG1660	Displays ATPase and GTPase activities
DNK48_RS39690	COG0445	tRNA wobble uridine modification
DNK48_RS39705	COG2197	response regulator
DNK48_RS39735	COG1940	carbohydrate kinase activity
DNK48_RS39770	COG1349	DNA-binding transcription factor activity
DNK48_RS39830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DNK48_RS39845	COG0494	nUDIX hydrolase
DNK48_RS39850	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS39875	COG2124	cytochrome p450
DNK48_RS39880	COG2124	cytochrome p450
DNK48_RS39890	COG0142	geranyltranstransferase activity
DNK48_RS39895	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DNK48_RS39895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNK48_RS39895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DNK48_RS39900	COG1461	Dihydroxyacetone kinase
DNK48_RS39905	COG2376	Dihydroxyacetone kinase
DNK48_RS39920	COG1960	acyl-CoA dehydrogenase activity
DNK48_RS39925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNK48_RS39960	COG2070	2-Nitropropane dioxygenase
DNK48_RS40060	COG0438	transferase activity, transferring glycosyl groups
DNK48_RS40085	COG1984	allophanate hydrolase subunit 2
DNK48_RS40090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DNK48_RS40095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DNK48_RS40115	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DNK48_RS40145	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS40150	COG4638	Rieske (2fe-2S)
DNK48_RS40175	COG2146	nitrite reductase [NAD(P)H] activity
DNK48_RS40195	COG2018	Roadblock/LC7 domain
DNK48_RS40210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNK48_RS40215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNK48_RS40230	COG3842	ATPase activity
DNK48_RS40235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DNK48_RS40240	COG1176	ABC-type spermidine putrescine transport system, permease component I
DNK48_RS40245	COG1177	transmembrane transport
DNK48_RS40250	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DNK48_RS40260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNK48_RS40280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DNK48_RS40315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DNK48_RS40355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNK48_RS40365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DNK48_RS40365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DNK48_RS40390	COG0384	phenazine biosynthesis protein PhzF
DNK48_RS40430	COG0583	DNA-binding transcription factor activity
DNK48_RS40475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DNK48_RS40485	COG2378	regulation of single-species biofilm formation
DNK48_RS40495	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS40520	COG0596	Alpha beta hydrolase
DNK48_RS40525	COG1335	isochorismatase
DNK48_RS40550	COG0477	Major facilitator Superfamily
DNK48_RS40555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS40560	COG2309	aminopeptidase activity
DNK48_RS40565	COG2318	DinB family
DNK48_RS40580	COG0673	inositol 2-dehydrogenase activity
DNK48_RS40585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DNK48_RS40600	COG2186	Transcriptional regulator
DNK48_RS40605	COG1113	amino acid transport
DNK48_RS40660	COG1024	Enoyl-CoA hydratase
DNK48_RS40665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DNK48_RS40670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DNK48_RS40675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNK48_RS40680	COG0254	rRNA binding
DNK48_RS40690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DNK48_RS40735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DNK48_RS40750	COG0583	DNA-binding transcription factor activity
DNK48_RS40770	COG1309	transcriptional regulator
DNK48_RS40775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DNK48_RS40780	COG1819	glycosyl
DNK48_RS40785	COG0477	Major facilitator Superfamily
DNK48_RS40790	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS40805	COG1316	TRANSCRIPTIONal
DNK48_RS40885	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS40910	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS40920	COG0431	NADPH-dependent FMN reductase
DNK48_RS40925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS40945	COG4585	Histidine kinase
DNK48_RS40950	COG2197	response regulator
DNK48_RS40955	COG1136	(ABC) transporter
DNK48_RS40955	COG0577	efflux transmembrane transporter activity
DNK48_RS40960	COG1136	(ABC) transporter
DNK48_RS40960	COG0577	efflux transmembrane transporter activity
DNK48_RS40990	COG2353	YceI-like domain
DNK48_RS41005	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS41015	COG0137	argininosuccinate synthase activity
DNK48_RS41025	COG0366	Alpha amylase catalytic
DNK48_RS41030	COG0395	ABC-type sugar transport system, permease component
DNK48_RS41035	COG1175	transmembrane transport
DNK48_RS41075	COG0604	alcohol dehydrogenase
DNK48_RS41075	COG3321	synthase
DNK48_RS41180	COG0587	DNA-directed DNA polymerase activity
DNK48_RS41215	COG3467	pyridoxamine 5'-phosphate
DNK48_RS41235	COG5006	permease, DMT superfamily
DNK48_RS41245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DNK48_RS41250	COG0789	Transcriptional regulator
DNK48_RS41260	COG0583	DNA-binding transcription factor activity
DNK48_RS41305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DNK48_RS41310	COG1053	succinate dehydrogenase
DNK48_RS41325	COG2072	flavoprotein involved in K transport
DNK48_RS41335	COG1063	alcohol dehydrogenase
DNK48_RS41340	COG0778	Nitroreductase
DNK48_RS41345	COG2197	response regulator
DNK48_RS41350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS41355	COG0604	alcohol dehydrogenase
DNK48_RS41355	COG3321	synthase
DNK48_RS41380	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DNK48_RS41405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DNK48_RS41415	COG3290	protein histidine kinase activity
DNK48_RS41445	COG0546	phosphoglycolate phosphatase activity
DNK48_RS41460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DNK48_RS41470	COG0789	Transcriptional regulator
DNK48_RS41505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DNK48_RS41505	COG0515	serine threonine protein kinase
DNK48_RS41515	COG0542	response to heat
DNK48_RS41545	COG3300	MHYT domain
DNK48_RS41545	COG5001	Diguanylate cyclase
DNK48_RS41555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DNK48_RS41590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DNK48_RS41600	COG4977	sequence-specific DNA binding
DNK48_RS41620	COG0431	NADPH-dependent FMN reductase
DNK48_RS41675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DNK48_RS41680	COG2815	serine threonine protein kinase
DNK48_RS41680	COG0515	serine threonine protein kinase
DNK48_RS41690	COG1294	oxidase, subunit
DNK48_RS41695	COG1271	oxidase subunit
DNK48_RS41700	COG0577	efflux transmembrane transporter activity
DNK48_RS41710	COG2197	response regulator
DNK48_RS41735	COG0673	inositol 2-dehydrogenase activity
DNK48_RS41745	COG1609	Transcriptional regulator
DNK48_RS41750	COG0395	ABC-type sugar transport system, permease component
DNK48_RS41755	COG1175	transmembrane transport
DNK48_RS41780	COG3119	arylsulfatase activity
DNK48_RS41805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DNK48_RS41830	COG0531	amino acid
DNK48_RS41845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DNK48_RS41860	COG1309	transcriptional regulator
DNK48_RS41885	COG2197	response regulator
DNK48_RS41895	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS41900	COG0475	glutathione-regulated potassium exporter activity
DNK48_RS41915	COG0492	ferredoxin-NADP+ reductase activity
DNK48_RS41920	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS41955	COG0673	inositol 2-dehydrogenase activity
DNK48_RS41960	COG0701	Predicted permease
DNK48_RS41975	COG0129	dihydroxy-acid dehydratase activity
DNK48_RS41980	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS41985	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS42020	COG2271	Major facilitator Superfamily
DNK48_RS42030	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DNK48_RS42040	COG2226	methyltransferase
DNK48_RS42045	COG3835	regulator
DNK48_RS42070	COG1012	belongs to the aldehyde dehydrogenase family
DNK48_RS42085	COG3509	depolymerase
DNK48_RS42090	COG0318	PFAM AMP-dependent synthetase and ligase
DNK48_RS42100	COG0156	8-amino-7-oxononanoate synthase activity
DNK48_RS42145	COG3321	synthase
DNK48_RS42145	COG0604	alcohol dehydrogenase
DNK48_RS42150	COG0604	alcohol dehydrogenase
DNK48_RS42150	COG3321	synthase
DNK48_RS42160	COG0656	L-ascorbic acid biosynthetic process
DNK48_RS42175	COG0488	(ABC) transporter
DNK48_RS42200	COG1819	glycosyl
DNK48_RS42210	COG0701	Predicted permease
DNK48_RS42220	COG1028	Short-chain dehydrogenase reductase Sdr
DNK48_RS42225	COG1472	Belongs to the glycosyl hydrolase 3 family
DNK48_RS42250	COG0435	Glutathione S-transferase
DNK48_RS42275	COG0477	Major facilitator Superfamily
DNK48_RS42285	COG2340	Cysteine-rich secretory protein family
DNK48_RS42295	COG1064	alcohol dehydrogenase
DNK48_RS42310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DNK48_RS42335	COG3291	Pkd domain containing protein
DNK48_RS42335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DNK48_RS42415	COG4221	oxidoreductase activity
DNK48_RS42425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DNK48_RS42445	COG1902	pentaerythritol trinitrate reductase activity
DNK48_RS42450	COG1968	undecaprenyl-diphosphatase activity
DNK48_RS42460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNK48_RS42465	COG1414	Transcriptional regulator
DNK48_RS42490	COG2610	gluconate transmembrane transporter activity
DNK48_RS42495	COG4948	Mandelate Racemase Muconate Lactonizing
DNK48_RS42510	COG3537	Alpha-1,2-mannosidase
DNK48_RS42530	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DNK48_RS42535	COG3387	PFAM Glycoside hydrolase 15-related
DNK48_RS42565	COG2197	response regulator
DNK48_RS42570	COG0668	transmembrane transport
DNK48_RS42575	COG2814	Major facilitator Superfamily
DNK48_RS42595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNK48_RS42600	COG0142	geranyltranstransferase activity
DNK48_RS42615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DNK48_RS42620	COG2175	clavaminate synthase activity
DNK48_RS42630	COG0739	heme binding
DNK48_RS42640	COG2508	Transcriptional regulator
DNK48_RS42650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNK48_RS42675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNK48_RS42700	COG0326	Molecular chaperone. Has ATPase activity
DNK48_RS42720	COG0412	Dienelactone hydrolase
DNK48_RS42750	COG2815	serine threonine protein kinase
DNK48_RS42750	COG0515	serine threonine protein kinase
DNK48_RS42790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DNK48_RS42795	COG2080	2 iron, 2 sulfur cluster binding
DNK48_RS42800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DNK48_RS42805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS42815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNK48_RS42875	COG3594	Acyltransferase
DNK48_RS42880	COG2376	Dihydroxyacetone kinase
DNK48_RS42885	COG2376	Dihydroxyacetone kinase
DNK48_RS42890	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DNK48_RS42895	COG4221	oxidoreductase activity
DNK48_RS42905	COG1309	transcriptional regulator
DNK48_RS42925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNK48_RS42935	COG4565	transcriptional regulatory protein
DNK48_RS42940	COG3290	protein histidine kinase activity
DNK48_RS42950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNK48_RS42955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DNK48_RS42960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DNK48_RS42975	COG0726	polysaccharide deacetylase
DNK48_RS42980	COG0114	fumarate hydratase activity
DNK48_RS42990	COG2267	carboxylic ester hydrolase activity
DNK48_RS43005	COG3903	Transcriptional regulator
DNK48_RS43005	COG3629	intracellular signal transduction
DNK48_RS43010	COG2175	clavaminate synthase activity
DNK48_RS43015	COG0583	DNA-binding transcription factor activity
DNK48_RS43030	COG0306	phosphate transporter
DNK48_RS43040	COG1357	PFAM Pentapeptide repeats (8 copies)
DNK48_RS43075	COG1131	(ABC) transporter
DNK48_RS43105	COG3511	phospholipase C
DNK48_RS43130	COG1051	belongs to the nudix hydrolase family
DNK48_RS43185	COG2356	endonuclease I
DNK48_RS43190	COG0328	RNA-DNA hybrid ribonuclease activity
DNK48_RS43235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DNK48_RS43240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DNK48_RS43245	COG2080	2 iron, 2 sulfur cluster binding
DNK48_RS43270	COG1982	Orn Lys Arg decarboxylase major
DNK48_RS43285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DNK48_RS43315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DNK48_RS43350	COG0508	dehydrogenase complex catalyzes the overall conversion of
DNK48_RS43360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DNK48_RS43385	COG0477	Major facilitator Superfamily
DNK48_RS43420	COG0667	Aldo Keto reductase
DNK48_RS43430	COG0789	Transcriptional regulator
DNK48_RS43440	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DNK48_RS43445	COG1017	nitric oxide dioxygenase activity
DNK48_RS43445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DNK48_RS43450	COG1959	2 iron, 2 sulfur cluster binding
DNK48_RS43485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DNK48_RS43500	COG0667	Aldo Keto reductase
DNK48_RS43505	COG2318	DinB family
DNK48_RS43515	COG2186	Transcriptional regulator
DNK48_RS43520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNK48_RS43525	COG3622	Belongs to the hyi family
DNK48_RS43530	COG2271	Major facilitator Superfamily
DNK48_RS43535	COG3395	kinase activity
DNK48_RS43540	COG2084	Dehydrogenase
DNK48_RS43550	COG0583	DNA-binding transcription factor activity