locus-tag	class	description
HEK616_RS00005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEK616_RS00035	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS00040	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS00055	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS00075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEK616_RS00090	COG1024	Enoyl-CoA hydratase
HEK616_RS00130	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS00140	COG1309	transcriptional regulator
HEK616_RS00145	COG0515	serine threonine protein kinase
HEK616_RS00145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEK616_RS00160	COG1024	Enoyl-CoA hydratase
HEK616_RS00175	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS00240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEK616_RS00270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEK616_RS00280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEK616_RS00295	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS00305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEK616_RS00330	COG1686	Belongs to the peptidase S11 family
HEK616_RS00340	COG0640	Transcriptional regulator
HEK616_RS00360	COG2205	protein histidine kinase activity
HEK616_RS00365	COG0514	ATP-dependent DNA helicase (RecQ)
HEK616_RS00385	COG0513	Belongs to the DEAD box helicase family
HEK616_RS00390	COG1278	Cold shock
HEK616_RS00405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HEK616_RS00430	COG1309	transcriptional regulator
HEK616_RS00450	COG1846	Transcriptional regulator
HEK616_RS00455	COG3384	dioxygenase
HEK616_RS00480	COG1247	-acetyltransferase
HEK616_RS00490	COG1349	DNA-binding transcription factor activity
HEK616_RS00495	COG1105	Belongs to the carbohydrate kinase PfkB family
HEK616_RS00500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEK616_RS00500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEK616_RS00500	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEK616_RS00510	COG1376	ErfK ybiS ycfS ynhG family protein
HEK616_RS00575	COG2188	Transcriptional regulator
HEK616_RS00580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEK616_RS00590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEK616_RS00610	COG1970	mechanosensitive ion channel activity
HEK616_RS00615	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEK616_RS00630	COG3263	regulation of cellular component size
HEK616_RS00640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEK616_RS00645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEK616_RS00655	COG0315	cyclic pyranopterin monophosphate synthase activity
HEK616_RS00660	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEK616_RS00660	COG0315	cyclic pyranopterin monophosphate synthase activity
HEK616_RS00690	COG0789	Transcriptional regulator
HEK616_RS00695	COG1725	Transcriptional regulator
HEK616_RS00715	COG0708	Exodeoxyribonuclease III
HEK616_RS00760	COG2072	flavoprotein involved in K transport
HEK616_RS00765	COG2267	carboxylic ester hydrolase activity
HEK616_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS00790	COG0793	Belongs to the peptidase S41A family
HEK616_RS00790	COG4946	Tricorn protease homolog
HEK616_RS00810	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS00840	COG0310	cobalt ion transport
HEK616_RS00850	COG1122	ATPase activity
HEK616_RS00875	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HEK616_RS00945	COG1660	Displays ATPase and GTPase activities
HEK616_RS00975	COG0084	hydrolase, TatD family'
HEK616_RS00980	COG4932	domain protein
HEK616_RS00980	COG3583	domain protein
HEK616_RS00980	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEK616_RS00985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEK616_RS00990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEK616_RS01020	COG0488	(ABC) transporter
HEK616_RS01055	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HEK616_RS01060	COG2197	response regulator
HEK616_RS01070	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS01080	COG4106	trans-aconitate 2-methyltransferase activity
HEK616_RS01095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEK616_RS01105	COG0193	aminoacyl-tRNA hydrolase activity
HEK616_RS01110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HEK616_RS01115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEK616_RS01120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEK616_RS01130	COG4585	Histidine kinase
HEK616_RS01155	COG1316	TRANSCRIPTIONal
HEK616_RS01165	COG0477	Major facilitator Superfamily
HEK616_RS01195	COG0515	serine threonine protein kinase
HEK616_RS01195	COG2815	serine threonine protein kinase
HEK616_RS01235	COG2814	Major facilitator Superfamily
HEK616_RS01245	COG2124	cytochrome p450
HEK616_RS01260	COG0148	phosphopyruvate hydratase activity
HEK616_RS01285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEK616_RS01290	COG0577	efflux transmembrane transporter activity
HEK616_RS01295	COG0577	efflux transmembrane transporter activity
HEK616_RS01295	COG1136	(ABC) transporter
HEK616_RS01310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEK616_RS01310	COG0463	Glycosyl transferase, family 2
HEK616_RS01340	COG0183	Belongs to the thiolase family
HEK616_RS01345	COG2755	lipolytic protein G-D-S-L family
HEK616_RS01360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEK616_RS01375	COG1609	Transcriptional regulator
HEK616_RS01385	COG1174	glycine betaine transport
HEK616_RS01390	COG1174	glycine betaine transport
HEK616_RS01435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEK616_RS01450	COG1228	amidohydrolase
HEK616_RS01455	COG1191	sigma factor activity
HEK616_RS01460	COG1366	Belongs to the anti-sigma-factor antagonist family
HEK616_RS01485	COG3104	oligopeptide transport
HEK616_RS01490	COG0745	RESPONSE REGULATOR receiver
HEK616_RS01495	COG2205	protein histidine kinase activity
HEK616_RS01535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEK616_RS01590	COG1316	TRANSCRIPTIONal
HEK616_RS01610	COG1316	TRANSCRIPTIONal
HEK616_RS01625	COG1316	TRANSCRIPTIONal
HEK616_RS01655	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HEK616_RS01655	COG0778	Nitroreductase
HEK616_RS01660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEK616_RS01695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEK616_RS01710	COG1482	cell wall glycoprotein biosynthetic process
HEK616_RS01720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEK616_RS01720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEK616_RS01720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEK616_RS01725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEK616_RS01765	COG0714	Associated with various cellular activities
HEK616_RS01785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEK616_RS01790	COG0745	RESPONSE REGULATOR receiver
HEK616_RS01795	COG5000	phosphorelay sensor kinase activity
HEK616_RS01795	COG5002	protein histidine kinase activity
HEK616_RS01800	COG0823	Involved in the tonB-independent uptake of proteins
HEK616_RS01810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEK616_RS01815	COG2197	response regulator
HEK616_RS01820	COG3214	Protein conserved in bacteria
HEK616_RS01830	COG0653	protein targeting
HEK616_RS01845	COG0546	phosphoglycolate phosphatase activity
HEK616_RS01850	COG2902	Dehydrogenase
HEK616_RS01855	COG1134	teichoic acid transport
HEK616_RS01865	COG1309	transcriptional regulator
HEK616_RS01870	COG0463	Glycosyl transferase, family 2
HEK616_RS01870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEK616_RS01885	COG0463	Glycosyl transferase, family 2
HEK616_RS01910	COG1215	transferase activity, transferring glycosyl groups
HEK616_RS01910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEK616_RS01915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEK616_RS01930	COG0395	ABC-type sugar transport system, permease component
HEK616_RS01935	COG1175	transmembrane transport
HEK616_RS01940	COG1653	transport
HEK616_RS01950	COG0515	serine threonine protein kinase
HEK616_RS01955	COG0515	serine threonine protein kinase
HEK616_RS01960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEK616_RS01975	COG2884	Cell division ATP-binding protein ftsE
HEK616_RS01980	COG2177	Part of the ABC transporter FtsEX involved in
HEK616_RS01985	COG0793	Belongs to the peptidase S41A family
HEK616_RS01990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEK616_RS02005	COG0583	DNA-binding transcription factor activity
HEK616_RS02020	COG2223	nitrite transmembrane transporter activity
HEK616_RS02040	COG3973	AAA domain
HEK616_RS02050	COG0776	regulation of translation
HEK616_RS02055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEK616_RS02060	COG1678	Uncharacterized ACR, COG1678
HEK616_RS02075	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEK616_RS02090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEK616_RS02125	COG1174	glycine betaine transport
HEK616_RS02130	COG0517	IMP dehydrogenase activity
HEK616_RS02130	COG1125	glycine betaine transport
HEK616_RS02135	COG1174	glycine betaine transport
HEK616_RS02145	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEK616_RS02150	COG0277	FAD linked oxidase domain protein
HEK616_RS02155	COG0222	ribosome binding
HEK616_RS02195	COG1335	isochorismatase
HEK616_RS02205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEK616_RS02215	COG1113	amino acid transport
HEK616_RS02245	COG1263	PTS System
HEK616_RS02250	COG1263	PTS System
HEK616_RS02255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEK616_RS02260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEK616_RS02270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEK616_RS02290	COG0477	Major facilitator Superfamily
HEK616_RS02300	COG2205	protein histidine kinase activity
HEK616_RS02315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEK616_RS02325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEK616_RS02355	COG2733	membrane
HEK616_RS02365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEK616_RS02395	COG0596	Alpha beta hydrolase
HEK616_RS02425	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEK616_RS02430	COG0673	inositol 2-dehydrogenase activity
HEK616_RS02435	COG1940	carbohydrate kinase activity
HEK616_RS02445	COG2188	Transcriptional regulator
HEK616_RS02450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEK616_RS02525	COG3397	chitin binding
HEK616_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS02560	COG1126	abc transporter atp-binding protein
HEK616_RS02565	COG0765	amino acid transport
HEK616_RS02570	COG0765	amino acid transport
HEK616_RS02585	COG0154	amidase activity
HEK616_RS02605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS02665	COG0492	ferredoxin-NADP+ reductase activity
HEK616_RS02705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEK616_RS02710	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS02755	COG2910	NAD(P)H-binding
HEK616_RS02765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEK616_RS02770	COG4977	sequence-specific DNA binding
HEK616_RS02780	COG0589	response to stress
HEK616_RS02785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEK616_RS02800	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS02815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEK616_RS02820	COG1309	transcriptional regulator
HEK616_RS02830	COG1946	Acyl-CoA thioesterase
HEK616_RS02860	COG0789	Transcriptional regulator
HEK616_RS02865	COG0667	Aldo Keto reductase
HEK616_RS02900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEK616_RS02905	COG0028	Belongs to the TPP enzyme family
HEK616_RS02915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HEK616_RS02920	COG1554	hydrolase, family 65, central catalytic
HEK616_RS02935	COG1472	Belongs to the glycosyl hydrolase 3 family
HEK616_RS02950	COG1609	Transcriptional regulator
HEK616_RS02955	COG0673	inositol 2-dehydrogenase activity
HEK616_RS02970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEK616_RS02990	COG0673	inositol 2-dehydrogenase activity
HEK616_RS03010	COG2814	Major facilitator Superfamily
HEK616_RS03015	COG0673	inositol 2-dehydrogenase activity
HEK616_RS03025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEK616_RS03035	COG3718	enzyme involved in inositol metabolism
HEK616_RS03040	COG3962	Belongs to the TPP enzyme family
HEK616_RS03060	COG1131	(ABC) transporter
HEK616_RS03075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HEK616_RS03085	COG1077	Cell shape determining protein MreB Mrl
HEK616_RS03090	COG0596	Alpha beta hydrolase
HEK616_RS03105	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS03120	COG1674	ftsk spoiiie
HEK616_RS03135	COG3415	Transposase
HEK616_RS03135	COG2801	Transposase and inactivated derivatives
HEK616_RS03140	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEK616_RS03155	COG1609	Transcriptional regulator
HEK616_RS03165	COG3621	Patatin-like phospholipase
HEK616_RS03215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEK616_RS03220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS03225	COG1132	(ABC) transporter
HEK616_RS03260	COG2197	response regulator
HEK616_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS03380	COG0105	UTP biosynthetic process
HEK616_RS03455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEK616_RS03460	COG0629	single-stranded DNA binding
HEK616_RS03485	COG1136	(ABC) transporter
HEK616_RS03500	COG2346	COG2346, Truncated hemoglobins
HEK616_RS03525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEK616_RS03535	COG2186	Transcriptional regulator
HEK616_RS03545	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS03555	COG1486	melibiose metabolic process
HEK616_RS03560	COG0395	ABC-type sugar transport system, permease component
HEK616_RS03565	COG1175	transmembrane transport
HEK616_RS03570	COG1653	transport
HEK616_RS03575	COG1846	Transcriptional regulator
HEK616_RS03575	COG1940	carbohydrate kinase activity
HEK616_RS03580	COG0668	transmembrane transport
HEK616_RS03630	COG4266	Belongs to the allantoicase family
HEK616_RS03665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEK616_RS03670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEK616_RS03675	COG1113	amino acid transport
HEK616_RS03680	COG1113	amino acid transport
HEK616_RS03690	COG1113	amino acid transport
HEK616_RS03695	COG0698	ribose 5-phosphate isomerase
HEK616_RS03710	COG1136	(ABC) transporter
HEK616_RS03710	COG0577	efflux transmembrane transporter activity
HEK616_RS03715	COG3594	Acyltransferase
HEK616_RS03740	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEK616_RS03745	COG0740	serine-type endopeptidase activity
HEK616_RS03750	COG0740	serine-type endopeptidase activity
HEK616_RS03755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEK616_RS03765	COG0525	valine-tRNA ligase activity
HEK616_RS03775	COG0768	penicillin binding
HEK616_RS03780	COG0285	dihydrofolate synthase activity
HEK616_RS03790	COG0105	UTP biosynthetic process
HEK616_RS03795	COG1077	Cell shape determining protein MreB Mrl
HEK616_RS03810	COG0768	penicillin binding
HEK616_RS03815	COG0772	Belongs to the SEDS family
HEK616_RS03880	COG2186	Transcriptional regulator
HEK616_RS03930	COG1530	ribonuclease E activity
HEK616_RS03935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEK616_RS03940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEK616_RS03945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEK616_RS03955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEK616_RS03965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEK616_RS03980	COG0501	Belongs to the peptidase M48B family
HEK616_RS03995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEK616_RS04005	COG0799	negative regulation of ribosome biogenesis
HEK616_RS04010	COG0588	phosphoglycerate mutase activity
HEK616_RS04045	COG0495	leucyl-tRNA aminoacylation
HEK616_RS04055	COG1307	EDD domain protein, DegV family
HEK616_RS04060	COG1555	photosystem II stabilization
HEK616_RS04065	COG1234	tRNA 3'-trailer cleavage
HEK616_RS04070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEK616_RS04075	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HEK616_RS04095	COG0268	Binds directly to 16S ribosomal RNA
HEK616_RS04100	COG0481	GTPase activity
HEK616_RS04130	COG1420	regulation of RNA biosynthetic process
HEK616_RS04135	COG0484	heat shock protein binding
HEK616_RS04155	COG0537	adenosine 5'-monophosphoramidase activity
HEK616_RS04160	COG1234	tRNA 3'-trailer cleavage
HEK616_RS04170	COG4948	Mandelate Racemase Muconate Lactonizing
HEK616_RS04185	COG1486	melibiose metabolic process
HEK616_RS04190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEK616_RS04200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEK616_RS04215	COG0667	Aldo Keto reductase
HEK616_RS04220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEK616_RS04230	COG2723	6-phospho-beta-galactosidase activity
HEK616_RS04245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEK616_RS04300	COG1381	Involved in DNA repair and RecF pathway recombination
HEK616_RS04305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEK616_RS04325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEK616_RS04330	COG1121	(ABC) transporter
HEK616_RS04340	COG0423	glycine-tRNA ligase activity
HEK616_RS04355	COG2197	response regulator
HEK616_RS04360	COG3415	Transposase
HEK616_RS04360	COG2801	Transposase and inactivated derivatives
HEK616_RS04370	COG1309	transcriptional regulator
HEK616_RS04375	COG0667	Aldo Keto reductase
HEK616_RS04380	COG0477	Major facilitator Superfamily
HEK616_RS04410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEK616_RS04410	COG0574	Belongs to the PEP-utilizing enzyme family
HEK616_RS04435	COG2175	clavaminate synthase activity
HEK616_RS04440	COG0395	ABC-type sugar transport system, permease component
HEK616_RS04445	COG1175	transmembrane transport
HEK616_RS04450	COG2182	Extracellular solute-binding protein
HEK616_RS04495	COG0531	amino acid
HEK616_RS04510	COG0640	Transcriptional regulator
HEK616_RS04525	COG2146	nitrite reductase [NAD(P)H] activity
HEK616_RS04525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEK616_RS04540	COG2197	response regulator
HEK616_RS04555	COG1473	amidohydrolase
HEK616_RS04625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEK616_RS04635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HEK616_RS04650	COG0358	DNA primase activity
HEK616_RS04660	COG1070	Carbohydrate kinase
HEK616_RS04710	COG1475	DNA binding
HEK616_RS04835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEK616_RS04865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEK616_RS05010	COG0776	regulation of translation
HEK616_RS05075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEK616_RS05080	COG0588	phosphoglycerate mutase activity
HEK616_RS05085	COG1077	Cell shape determining protein MreB Mrl
HEK616_RS05110	COG2226	methyltransferase
HEK616_RS05120	COG4981	capsule polysaccharide biosynthetic process
HEK616_RS05125	COG0500	methyltransferase
HEK616_RS05155	COG0477	Major facilitator Superfamily
HEK616_RS05160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEK616_RS05170	COG2130	NADP-dependent
HEK616_RS05175	COG1764	response to oxidative stress
HEK616_RS05180	COG1609	Transcriptional regulator
HEK616_RS05185	COG1129	ABC transporter
HEK616_RS05195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEK616_RS05250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS05255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEK616_RS05260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEK616_RS05285	COG0789	Transcriptional regulator
HEK616_RS05290	COG0667	Aldo Keto reductase
HEK616_RS05305	COG2197	response regulator
HEK616_RS05310	COG4585	Histidine kinase
HEK616_RS05325	COG1309	transcriptional regulator
HEK616_RS05330	COG0477	Major facilitator Superfamily
HEK616_RS05340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEK616_RS05385	COG1358	cellular component organization or biogenesis
HEK616_RS05410	COG0800	Aldolase
HEK616_RS05415	COG4948	Mandelate Racemase Muconate Lactonizing
HEK616_RS05470	COG0596	Alpha beta hydrolase
HEK616_RS05485	COG1072	(Pantothenic acid kinase))
HEK616_RS05615	COG2124	cytochrome p450
HEK616_RS05620	COG0183	Belongs to the thiolase family
HEK616_RS05630	COG3845	ABC transporter
HEK616_RS05655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEK616_RS05675	COG1309	transcriptional regulator
HEK616_RS05680	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS05700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS05710	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEK616_RS05720	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS05725	COG0183	Belongs to the thiolase family
HEK616_RS05735	COG2197	response regulator
HEK616_RS05740	COG4585	Histidine kinase
HEK616_RS05750	COG1131	(ABC) transporter
HEK616_RS05755	COG2030	dehydratase
HEK616_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS05780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEK616_RS05795	COG0800	Aldolase
HEK616_RS05800	COG3022	response to hydroperoxide
HEK616_RS05805	COG0557	exoribonuclease II activity
HEK616_RS05840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEK616_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS05870	COG3540	Alkaline phosphatase
HEK616_RS05875	COG2814	Major facilitator Superfamily
HEK616_RS05880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEK616_RS05910	COG0672	)-iron permease
HEK616_RS05915	COG2837	iron assimilation
HEK616_RS05940	COG5398	heme oxygenase
HEK616_RS05965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEK616_RS05970	COG2186	Transcriptional regulator
HEK616_RS05985	COG1175	transmembrane transport
HEK616_RS05990	COG0395	ABC-type sugar transport system, permease component
HEK616_RS06005	COG1994	Peptidase M50
HEK616_RS06025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEK616_RS06030	COG0477	Major facilitator Superfamily
HEK616_RS06035	COG1309	transcriptional regulator
HEK616_RS06045	COG2814	Major facilitator Superfamily
HEK616_RS06050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEK616_RS06050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEK616_RS06055	COG2132	Multicopper oxidase
HEK616_RS06065	COG2267	carboxylic ester hydrolase activity
HEK616_RS06070	COG0174	glutamine synthetase
HEK616_RS06075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEK616_RS06085	COG1609	Transcriptional regulator
HEK616_RS06090	COG0366	Alpha amylase catalytic
HEK616_RS06095	COG2182	Extracellular solute-binding protein
HEK616_RS06100	COG1175	transmembrane transport
HEK616_RS06105	COG0395	ABC-type sugar transport system, permease component
HEK616_RS06115	COG0366	Alpha amylase catalytic
HEK616_RS06210	COG0745	RESPONSE REGULATOR receiver
HEK616_RS06240	COG0673	inositol 2-dehydrogenase activity
HEK616_RS06245	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS06255	COG1695	Transcriptional regulator
HEK616_RS06260	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEK616_RS06260	COG1902	pentaerythritol trinitrate reductase activity
HEK616_RS06275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEK616_RS06305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEK616_RS06310	COG0321	lipoyl(octanoyl) transferase activity
HEK616_RS06350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEK616_RS06360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEK616_RS06365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEK616_RS06370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEK616_RS06375	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HEK616_RS06390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEK616_RS06390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEK616_RS06395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEK616_RS06430	COG4585	Histidine kinase
HEK616_RS06435	COG2197	response regulator
HEK616_RS06440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEK616_RS06455	COG3629	intracellular signal transduction
HEK616_RS06455	COG3903	Transcriptional regulator
HEK616_RS06500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HEK616_RS06515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEK616_RS06525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEK616_RS06530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEK616_RS06540	COG1376	ErfK ybiS ycfS ynhG family protein
HEK616_RS06550	COG1845	cytochrome c oxidase, subunit III
HEK616_RS06555	COG2010	Cytochrome c
HEK616_RS06560	COG0723	plastoquinol--plastocyanin reductase activity
HEK616_RS06565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEK616_RS06570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEK616_RS06575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEK616_RS06585	COG0705	Rhomboid family
HEK616_RS06620	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS06640	COG0003	Pfam Anion-transporting ATPase
HEK616_RS06650	COG1940	carbohydrate kinase activity
HEK616_RS06680	COG2197	response regulator
HEK616_RS06685	COG0205	6-phosphofructokinase activity
HEK616_RS06690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEK616_RS06700	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEK616_RS06710	COG2193	ferroxidase activity
HEK616_RS06715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEK616_RS06720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HEK616_RS06725	COG2815	serine threonine protein kinase
HEK616_RS06725	COG0515	serine threonine protein kinase
HEK616_RS06730	COG2022	thiamine diphosphate biosynthetic process
HEK616_RS06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEK616_RS06740	COG2022	thiamine diphosphate biosynthetic process
HEK616_RS06755	COG0352	thiamine-phosphate diphosphorylase activity
HEK616_RS06770	COG1233	COG1233 Phytoene dehydrogenase and related
HEK616_RS06780	COG1309	transcriptional regulator
HEK616_RS06800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEK616_RS06820	COG0714	Associated with various cellular activities
HEK616_RS06830	COG0275	rRNA processing
HEK616_RS06845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEK616_RS06850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEK616_RS06855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEK616_RS06860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEK616_RS06870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEK616_RS06875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEK616_RS06895	COG1799	cell septum assembly
HEK616_RS06905	COG3599	regulation of cell shape
HEK616_RS06910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEK616_RS06920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEK616_RS06975	COG0587	DNA-directed DNA polymerase activity
HEK616_RS06985	COG1432	Conserved Protein
HEK616_RS07005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEK616_RS07020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEK616_RS07025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEK616_RS07030	COG0131	Imidazoleglycerol-phosphate dehydratase
HEK616_RS07040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEK616_RS07045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEK616_RS07050	COG0251	oxidation-reduction process
HEK616_RS07055	COG0107	imidazoleglycerol-phosphate synthase activity
HEK616_RS07060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEK616_RS07065	COG1053	succinate dehydrogenase
HEK616_RS07075	COG0583	DNA-binding transcription factor activity
HEK616_RS07090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEK616_RS07095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEK616_RS07115	COG0134	indole-3-glycerol-phosphate synthase activity
HEK616_RS07125	COG0133	tryptophan synthase activity
HEK616_RS07130	COG0159	tryptophan synthase activity
HEK616_RS07140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HEK616_RS07150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEK616_RS07180	COG0067	glutamate synthase
HEK616_RS07180	COG0069	glutamate synthase activity
HEK616_RS07180	COG0070	glutamate synthase
HEK616_RS07200	COG0640	Transcriptional regulator
HEK616_RS07220	COG1609	Transcriptional regulator
HEK616_RS07245	COG0366	Alpha amylase catalytic
HEK616_RS07245	COG1470	cell adhesion involved in biofilm formation
HEK616_RS07275	COG0737	Belongs to the 5'-nucleotidase family
HEK616_RS07310	COG0411	ABC transporter
HEK616_RS07320	COG0559	Belongs to the binding-protein-dependent transport system permease family
HEK616_RS07330	COG2050	protein possibly involved in aromatic compounds catabolism
HEK616_RS07365	COG1643	Atp-dependent helicase
HEK616_RS07370	COG2226	methyltransferase
HEK616_RS07375	COG0539	negative regulation of cytoplasmic translation
HEK616_RS07390	COG0237	dephospho-CoA kinase activity
HEK616_RS07415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEK616_RS07475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEK616_RS07480	COG0584	glycerophosphoryl diester phosphodiesterase
HEK616_RS07485	COG0556	nucleotide-excision repair
HEK616_RS07525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEK616_RS07535	COG1609	Transcriptional regulator
HEK616_RS07540	COG1063	alcohol dehydrogenase
HEK616_RS07570	COG0322	excinuclease ABC activity
HEK616_RS07575	COG1660	Displays ATPase and GTPase activities
HEK616_RS07580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEK616_RS07585	COG1481	regulation of sporulation
HEK616_RS07590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEK616_RS07595	COG0126	phosphoglycerate kinase activity
HEK616_RS07600	COG0149	triose-phosphate isomerase activity
HEK616_RS07605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEK616_RS07615	COG0166	Belongs to the GPI family
HEK616_RS07620	COG0363	glucosamine-6-phosphate deaminase activity
HEK616_RS07635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEK616_RS07645	COG0109	protoheme IX farnesyltransferase activity
HEK616_RS07660	COG1612	heme a metabolic process
HEK616_RS07685	COG0719	Fe-S assembly protein
HEK616_RS07695	COG0396	ATPase activity
HEK616_RS07700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEK616_RS07705	COG0822	iron-sulfur transferase activity
HEK616_RS07720	COG2171	N-acyltransferase activity
HEK616_RS07730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEK616_RS07755	COG2226	methyltransferase
HEK616_RS07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS07775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEK616_RS07780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEK616_RS07790	COG2197	response regulator
HEK616_RS07795	COG4585	Histidine kinase
HEK616_RS07800	COG1414	Transcriptional regulator
HEK616_RS07830	COG1902	pentaerythritol trinitrate reductase activity
HEK616_RS07840	COG1917	Cupin 2, conserved barrel domain protein
HEK616_RS07845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEK616_RS07860	COG0385	Bile acid
HEK616_RS07875	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HEK616_RS07890	COG1797	cobyrinic acid a,c-diamide synthase activity
HEK616_RS07895	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HEK616_RS07905	COG1492	cobalamin metabolic process
HEK616_RS07910	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEK616_RS07925	COG1653	transport
HEK616_RS07940	COG0235	Class ii aldolase
HEK616_RS07960	COG0488	(ABC) transporter
HEK616_RS07970	COG1024	Enoyl-CoA hydratase
HEK616_RS08010	COG3387	PFAM Glycoside hydrolase 15-related
HEK616_RS08055	COG3340	Belongs to the peptidase S51 family
HEK616_RS08070	COG1404	Belongs to the peptidase S8 family
HEK616_RS08085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEK616_RS08090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEK616_RS08105	COG2261	transglycosylase associated protein
HEK616_RS08110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEK616_RS08130	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS08135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEK616_RS08140	COG2186	Transcriptional regulator
HEK616_RS08165	COG0560	Phosphoserine phosphatase
HEK616_RS08165	COG3830	Belongs to the UPF0237 family
HEK616_RS08170	COG1716	ATPase activity
HEK616_RS08170	COG1131	(ABC) transporter
HEK616_RS08170	COG0842	Transport permease protein
HEK616_RS08185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEK616_RS08195	COG4585	Histidine kinase
HEK616_RS08200	COG2197	response regulator
HEK616_RS08230	COG1119	ATPase activity
HEK616_RS08255	COG1881	PFAM PEBP family protein
HEK616_RS08265	COG2094	Belongs to the DNA glycosylase MPG family
HEK616_RS08305	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HEK616_RS08320	COG0647	UMP catabolic process
HEK616_RS08335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEK616_RS08340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEK616_RS08345	COG1120	ATPase activity
HEK616_RS08365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEK616_RS08380	COG0497	DNA recombination
HEK616_RS08415	COG3387	PFAM Glycoside hydrolase 15-related
HEK616_RS08420	COG0504	CTP synthase activity
HEK616_RS08425	COG0494	nUDIX hydrolase
HEK616_RS08435	COG0686	Belongs to the AlaDH PNT family
HEK616_RS08450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEK616_RS08455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEK616_RS08460	COG1187	pseudouridine synthase activity
HEK616_RS08485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEK616_RS08495	COG1160	GTP binding
HEK616_RS08525	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS08540	COG0671	phosphoesterase, PA-phosphatase related
HEK616_RS08550	COG0477	Major facilitator Superfamily
HEK616_RS08555	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS08560	COG1799	cell septum assembly
HEK616_RS08575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS08580	COG0765	amino acid transport
HEK616_RS08615	COG0330	HflC and HflK could
HEK616_RS08655	COG0587	DNA-directed DNA polymerase activity
HEK616_RS08660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEK616_RS08685	COG0531	amino acid
HEK616_RS08690	COG1522	sequence-specific DNA binding
HEK616_RS08700	COG2264	protein methyltransferase activity
HEK616_RS08705	COG0454	-acetyltransferase
HEK616_RS08705	COG0456	acetyltransferase
HEK616_RS08710	COG0367	asparagine synthase
HEK616_RS08715	COG1725	Transcriptional regulator
HEK616_RS08720	COG1834	amidinotransferase
HEK616_RS08760	COG1649	PFAM Uncharacterised BCR, COG1649
HEK616_RS08760	COG0726	polysaccharide deacetylase
HEK616_RS08770	COG0463	Glycosyl transferase, family 2
HEK616_RS08785	COG3619	membrane
HEK616_RS08810	COG0477	Major facilitator Superfamily
HEK616_RS08810	COG2814	Major facilitator Superfamily
HEK616_RS08820	COG0702	epimerase
HEK616_RS08825	COG0583	DNA-binding transcription factor activity
HEK616_RS08830	COG2188	Transcriptional regulator
HEK616_RS08835	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEK616_RS08840	COG1309	transcriptional regulator
HEK616_RS08845	COG2851	Citrate transporter
HEK616_RS08860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEK616_RS08875	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS08890	COG1051	belongs to the nudix hydrolase family
HEK616_RS08925	COG0477	Major facilitator Superfamily
HEK616_RS08940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEK616_RS08945	COG0047	phosphoribosylformylglycinamidine synthase activity
HEK616_RS08950	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEK616_RS08955	COG2072	flavoprotein involved in K transport
HEK616_RS08975	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS08995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEK616_RS09020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HEK616_RS09025	COG3876	Protein conserved in bacteria
HEK616_RS09035	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS09040	COG1309	transcriptional regulator
HEK616_RS09065	COG2149	membrane
HEK616_RS09070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEK616_RS09110	COG2205	protein histidine kinase activity
HEK616_RS09115	COG0745	RESPONSE REGULATOR receiver
HEK616_RS09125	COG2124	cytochrome p450
HEK616_RS09130	COG0488	(ABC) transporter
HEK616_RS09150	COG0564	pseudouridine synthase activity
HEK616_RS09160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEK616_RS09195	COG0667	Aldo Keto reductase
HEK616_RS09200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS09210	COG0598	Magnesium transport protein CorA
HEK616_RS09230	COG0215	cysteine-tRNA ligase activity
HEK616_RS09245	COG4948	Mandelate Racemase Muconate Lactonizing
HEK616_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS09260	COG1129	ABC transporter
HEK616_RS09265	COG4211	Belongs to the binding-protein-dependent transport system permease family
HEK616_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS09285	COG2186	Transcriptional regulator
HEK616_RS09290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEK616_RS09295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEK616_RS09300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEK616_RS09305	COG1414	Transcriptional regulator
HEK616_RS09310	COG0646	methionine synthase
HEK616_RS09310	COG1410	methionine synthase
HEK616_RS09315	COG0546	phosphoglycolate phosphatase activity
HEK616_RS09320	COG4166	transmembrane transport
HEK616_RS09325	COG4166	transmembrane transport
HEK616_RS09330	COG2197	response regulator
HEK616_RS09340	COG0517	IMP dehydrogenase activity
HEK616_RS09340	COG1994	Peptidase M50
HEK616_RS09360	COG1222	aaa ATPase
HEK616_RS09365	COG4122	O-methyltransferase activity
HEK616_RS09380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEK616_RS09385	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEK616_RS09390	COG1609	Transcriptional regulator
HEK616_RS09400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEK616_RS09405	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEK616_RS09415	COG2378	regulation of single-species biofilm formation
HEK616_RS09435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEK616_RS09440	COG0805	protein transport
HEK616_RS09450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS09485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEK616_RS09490	COG4175	Glycine betaine
HEK616_RS09490	COG0517	IMP dehydrogenase activity
HEK616_RS09520	COG2233	PERMEase
HEK616_RS09540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEK616_RS09545	COG0531	amino acid
HEK616_RS09550	COG2186	Transcriptional regulator
HEK616_RS09585	COG1404	Belongs to the peptidase S8 family
HEK616_RS09595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEK616_RS09605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEK616_RS09610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HEK616_RS09615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEK616_RS09620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEK616_RS09625	COG5002	protein histidine kinase activity
HEK616_RS09630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEK616_RS09635	COG0072	phenylalanine-tRNA ligase activity
HEK616_RS09635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEK616_RS09650	COG1649	PFAM Uncharacterised BCR, COG1649
HEK616_RS09660	COG0697	spore germination
HEK616_RS09690	COG0657	acetylesterase activity
HEK616_RS09705	COG4106	trans-aconitate 2-methyltransferase activity
HEK616_RS09715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEK616_RS09720	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEK616_RS09725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEK616_RS09730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEK616_RS09735	COG1438	arginine binding
HEK616_RS09755	COG0137	argininosuccinate synthase activity
HEK616_RS09760	COG0165	Argininosuccinate lyase
HEK616_RS09770	COG0477	Major facilitator Superfamily
HEK616_RS09785	COG0584	glycerophosphoryl diester phosphodiesterase
HEK616_RS09810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEK616_RS09815	COG2011	ABC-type metal ion transport system permease component
HEK616_RS09820	COG1464	Belongs to the NlpA lipoprotein family
HEK616_RS09835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEK616_RS09840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEK616_RS09840	COG1648	precorrin-2 dehydrogenase activity
HEK616_RS09895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEK616_RS09905	COG0456	acetyltransferase
HEK616_RS09905	COG0454	-acetyltransferase
HEK616_RS09955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEK616_RS09970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEK616_RS10005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEK616_RS10010	COG1560	Kdo2-lipid A biosynthetic process
HEK616_RS10015	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS10025	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HEK616_RS10030	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HEK616_RS10035	COG0217	transcriptional regulatory protein
HEK616_RS10040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HEK616_RS10045	COG0632	four-way junction helicase activity
HEK616_RS10050	COG2255	four-way junction helicase activity
HEK616_RS10060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEK616_RS10065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEK616_RS10070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEK616_RS10075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEK616_RS10080	COG1196	nuclear chromosome segregation
HEK616_RS10085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEK616_RS10095	COG0124	histidyl-tRNA synthetase
HEK616_RS10115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEK616_RS10135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEK616_RS10140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEK616_RS10150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEK616_RS10155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEK616_RS10160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEK616_RS10165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEK616_RS10170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEK616_RS10180	COG0006	proline dipeptidase activity
HEK616_RS10185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEK616_RS10190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEK616_RS10200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEK616_RS10205	COG0540	Belongs to the ATCase OTCase family
HEK616_RS10210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEK616_RS10220	COG0505	Belongs to the CarA family
HEK616_RS10225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEK616_RS10230	COG0167	dihydroorotate dehydrogenase activity
HEK616_RS10235	COG0284	orotidine-5'-phosphate decarboxylase activity
HEK616_RS10260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEK616_RS10275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEK616_RS10280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEK616_RS10290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEK616_RS10295	COG2390	Transcriptional regulator
HEK616_RS10315	COG0531	amino acid
HEK616_RS10330	COG0477	Major facilitator Superfamily
HEK616_RS10340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEK616_RS10365	COG2233	PERMEase
HEK616_RS10395	COG3629	intracellular signal transduction
HEK616_RS10400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEK616_RS10435	COG2197	response regulator
HEK616_RS10440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEK616_RS10450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS10465	COG0738	Major facilitator superfamily
HEK616_RS10470	COG1940	carbohydrate kinase activity
HEK616_RS10470	COG1846	Transcriptional regulator
HEK616_RS10475	COG1090	epimerase
HEK616_RS10490	COG3201	nicotinamide mononucleotide transporter
HEK616_RS10495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEK616_RS10495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEK616_RS10500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEK616_RS10505	COG0140	phosphoribosyl-ATP diphosphatase activity
HEK616_RS10510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEK616_RS10595	COG0765	amino acid transport
HEK616_RS10605	COG0584	glycerophosphoryl diester phosphodiesterase
HEK616_RS10655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEK616_RS10665	COG2318	DinB family
HEK616_RS10690	COG3345	alpha-galactosidase
HEK616_RS10705	COG0395	ABC-type sugar transport system, permease component
HEK616_RS10720	COG0445	tRNA wobble uridine modification
HEK616_RS10725	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS10745	COG4585	Histidine kinase
HEK616_RS10750	COG2197	response regulator
HEK616_RS10765	COG2223	nitrite transmembrane transporter activity
HEK616_RS10770	COG1940	carbohydrate kinase activity
HEK616_RS10815	COG1349	DNA-binding transcription factor activity
HEK616_RS10845	COG3217	Mosc domain protein beta barrel domain protein
HEK616_RS10845	COG0633	Ferredoxin
HEK616_RS10860	COG0463	Glycosyl transferase, family 2
HEK616_RS10865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HEK616_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS10925	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS10930	COG1271	oxidase subunit
HEK616_RS10945	COG3387	PFAM Glycoside hydrolase 15-related
HEK616_RS11005	COG4221	oxidoreductase activity
HEK616_RS11035	COG0647	UMP catabolic process
HEK616_RS11050	COG1793	dna ligase
HEK616_RS11070	COG0395	ABC-type sugar transport system, permease component
HEK616_RS11110	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS11135	COG1461	Dihydroxyacetone kinase
HEK616_RS11140	COG2376	Dihydroxyacetone kinase
HEK616_RS11150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEK616_RS11155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEK616_RS11160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEK616_RS11170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEK616_RS11190	COG0589	response to stress
HEK616_RS11270	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEK616_RS11295	COG1007	ATP synthesis coupled electron transport
HEK616_RS11300	COG1006	Multisubunit Na H antiporter MnhC subunit
HEK616_RS11310	COG2111	Na H antiporter
HEK616_RS11310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEK616_RS11325	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEK616_RS11340	COG0243	molybdopterin cofactor binding
HEK616_RS11360	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS11370	COG0515	serine threonine protein kinase
HEK616_RS11385	COG2070	2-Nitropropane dioxygenase
HEK616_RS11395	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS11410	COG2267	carboxylic ester hydrolase activity
HEK616_RS11425	COG1024	Enoyl-CoA hydratase
HEK616_RS11500	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS11505	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS11525	COG1984	allophanate hydrolase subunit 2
HEK616_RS11530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HEK616_RS11535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HEK616_RS11555	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HEK616_RS11580	COG1414	Transcriptional regulator
HEK616_RS11585	COG2146	nitrite reductase [NAD(P)H] activity
HEK616_RS11620	COG0596	Alpha beta hydrolase
HEK616_RS11635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEK616_RS11640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEK616_RS11655	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEK616_RS11665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEK616_RS11675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEK616_RS11705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEK616_RS11725	COG1716	ATPase activity
HEK616_RS11745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEK616_RS11755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEK616_RS11755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEK616_RS11835	COG0697	spore germination
HEK616_RS11845	COG0825	malonyl-CoA metabolic process
HEK616_RS11845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEK616_RS11850	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS11875	COG0596	Alpha beta hydrolase
HEK616_RS11880	COG2814	Major facilitator Superfamily
HEK616_RS11895	COG0488	(ABC) transporter
HEK616_RS11935	COG0667	Aldo Keto reductase
HEK616_RS11940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEK616_RS11965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEK616_RS11975	COG1132	(ABC) transporter
HEK616_RS11980	COG2318	DinB family
HEK616_RS11990	COG0386	Belongs to the glutathione peroxidase family
HEK616_RS12015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS12020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEK616_RS12050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEK616_RS12080	COG0297	glycogen (starch) synthase activity
HEK616_RS12105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEK616_RS12135	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HEK616_RS12175	COG3835	regulator
HEK616_RS12190	COG3585	molybdate ion transport
HEK616_RS12225	COG0477	Major facilitator Superfamily
HEK616_RS12245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEK616_RS12245	COG1024	Enoyl-CoA hydratase
HEK616_RS12250	COG0745	RESPONSE REGULATOR receiver
HEK616_RS12270	COG2318	DinB family
HEK616_RS12310	COG5001	Diguanylate cyclase
HEK616_RS12320	COG3387	PFAM Glycoside hydrolase 15-related
HEK616_RS12360	COG1063	alcohol dehydrogenase
HEK616_RS12365	COG0156	8-amino-7-oxononanoate synthase activity
HEK616_RS12370	COG0583	DNA-binding transcription factor activity
HEK616_RS12380	COG1796	DNA polymerase
HEK616_RS12380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HEK616_RS12395	COG2274	protein secretion by the type I secretion system
HEK616_RS12400	COG2274	protein secretion by the type I secretion system
HEK616_RS12415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEK616_RS12420	COG1120	ATPase activity
HEK616_RS12465	COG4257	antibiotic catabolic process
HEK616_RS12510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEK616_RS12545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEK616_RS12555	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS12560	COG0531	amino acid
HEK616_RS12570	COG0640	Transcriptional regulator
HEK616_RS12590	COG2186	Transcriptional regulator
HEK616_RS12600	COG4565	transcriptional regulatory protein
HEK616_RS12605	COG3290	protein histidine kinase activity
HEK616_RS12615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEK616_RS12650	COG1864	DNA RNA non-specific endonuclease
HEK616_RS12650	COG3591	Belongs to the peptidase S1B family
HEK616_RS12690	COG1573	uracil-dna glycosylase
HEK616_RS12705	COG0513	Belongs to the DEAD box helicase family
HEK616_RS12720	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEK616_RS12730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS12740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEK616_RS12750	COG1509	lysine 2,3-aminomutase activity
HEK616_RS12755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEK616_RS12770	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS12785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS12795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEK616_RS12820	COG4214	carbohydrate transport
HEK616_RS12830	COG4213	ABC transporter substrate-binding protein
HEK616_RS12860	COG1113	amino acid transport
HEK616_RS12880	COG3594	Acyltransferase
HEK616_RS12885	COG1968	undecaprenyl-diphosphatase activity
HEK616_RS12990	COG1191	sigma factor activity
HEK616_RS13010	COG2890	protein-(glutamine-N5) methyltransferase activity
HEK616_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS13090	COG5592	hemerythrin HHE cation binding domain
HEK616_RS13095	COG0028	Belongs to the TPP enzyme family
HEK616_RS13100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEK616_RS13120	COG0297	glycogen (starch) synthase activity
HEK616_RS13165	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS13200	COG0515	serine threonine protein kinase
HEK616_RS13200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEK616_RS13270	COG0009	L-threonylcarbamoyladenylate synthase
HEK616_RS13290	COG0445	tRNA wobble uridine modification
HEK616_RS13300	COG1674	ftsk spoiiie
HEK616_RS13320	COG2378	regulation of single-species biofilm formation
HEK616_RS13350	COG3409	Peptidoglycan-binding domain 1 protein
HEK616_RS13350	COG3757	hydrolase, family 25
HEK616_RS13360	COG0405	Gamma-glutamyltransferase
HEK616_RS13380	COG0789	Transcriptional regulator
HEK616_RS13390	COG0154	amidase activity
HEK616_RS13405	COG0326	Molecular chaperone. Has ATPase activity
HEK616_RS13495	COG0010	Belongs to the arginase family
HEK616_RS13500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEK616_RS13535	COG0577	efflux transmembrane transporter activity
HEK616_RS13535	COG1136	(ABC) transporter
HEK616_RS13550	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS13555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEK616_RS13575	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEK616_RS13595	COG0395	ABC-type sugar transport system, permease component
HEK616_RS13600	COG1175	transmembrane transport
HEK616_RS13605	COG1653	transport
HEK616_RS13610	COG0366	Alpha amylase catalytic
HEK616_RS13615	COG1653	transport
HEK616_RS13625	COG1136	(ABC) transporter
HEK616_RS13625	COG0577	efflux transmembrane transporter activity
HEK616_RS13655	COG0302	gtp cyclohydrolase
HEK616_RS13675	COG1309	transcriptional regulator
HEK616_RS13695	COG0667	Aldo Keto reductase
HEK616_RS13705	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS13710	COG3511	phospholipase C
HEK616_RS13735	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS13775	COG0583	DNA-binding transcription factor activity
HEK616_RS13785	COG4608	Belongs to the ABC transporter superfamily
HEK616_RS13795	COG0601	transmembrane transport
HEK616_RS13800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEK616_RS13810	COG0006	proline dipeptidase activity
HEK616_RS13815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEK616_RS13835	COG3938	Belongs to the proline racemase family
HEK616_RS13845	COG1802	Transcriptional regulator
HEK616_RS13890	COG3963	phosphatidate phosphatase activity
HEK616_RS13900	COG2267	carboxylic ester hydrolase activity
HEK616_RS13910	COG1231	oxidoreductase activity
HEK616_RS13935	COG1017	nitric oxide dioxygenase activity
HEK616_RS13935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEK616_RS13940	COG0745	RESPONSE REGULATOR receiver
HEK616_RS13945	COG2205	protein histidine kinase activity
HEK616_RS13980	COG1316	TRANSCRIPTIONal
HEK616_RS14020	COG0517	IMP dehydrogenase activity
HEK616_RS14030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEK616_RS14035	COG0569	domain protein
HEK616_RS14045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEK616_RS14085	COG0517	IMP dehydrogenase activity
HEK616_RS14085	COG0516	GMP reductase activity
HEK616_RS14090	COG0517	IMP dehydrogenase activity
HEK616_RS14090	COG0516	GMP reductase activity
HEK616_RS14100	COG2239	Acts as a magnesium transporter
HEK616_RS14155	COG3209	COG3209 Rhs family protein
HEK616_RS14215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEK616_RS14230	COG0798	PFAM Bile acid sodium symporter
HEK616_RS14245	COG0110	maltose O-acetyltransferase activity
HEK616_RS14250	COG1309	transcriptional regulator
HEK616_RS14260	COG3594	Acyltransferase
HEK616_RS14265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEK616_RS14305	COG1794	racemase activity, acting on amino acids and derivatives
HEK616_RS14320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEK616_RS14340	COG0477	Major facilitator Superfamily
HEK616_RS14355	COG0181	hydroxymethylbilane synthase activity
HEK616_RS14365	COG2409	Drug exporters of the RND superfamily
HEK616_RS14380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS14395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEK616_RS14410	COG3387	PFAM Glycoside hydrolase 15-related
HEK616_RS14440	COG2318	DinB family
HEK616_RS14480	COG2301	Belongs to the HpcH HpaI aldolase family
HEK616_RS14500	COG0431	NADPH-dependent FMN reductase
HEK616_RS14515	COG0697	spore germination
HEK616_RS14535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEK616_RS14550	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HEK616_RS14570	COG2814	Major facilitator Superfamily
HEK616_RS14575	COG1063	alcohol dehydrogenase
HEK616_RS14580	COG1349	DNA-binding transcription factor activity
HEK616_RS14645	COG1366	Belongs to the anti-sigma-factor antagonist family
HEK616_RS14650	COG1366	Belongs to the anti-sigma-factor antagonist family
HEK616_RS14655	COG2172	sigma factor antagonist activity
HEK616_RS14715	COG0297	glycogen (starch) synthase activity
HEK616_RS14720	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS14725	COG0110	maltose O-acetyltransferase activity
HEK616_RS14730	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEK616_RS14735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEK616_RS14740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEK616_RS14825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS14840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS14850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS14865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS14880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEK616_RS14890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEK616_RS14895	COG1796	DNA polymerase
HEK616_RS14895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HEK616_RS14905	COG0477	Major facilitator Superfamily
HEK616_RS14915	COG4941	Belongs to the sigma-70 factor family
HEK616_RS14920	COG2226	methyltransferase
HEK616_RS14925	COG0745	RESPONSE REGULATOR receiver
HEK616_RS14990	COG1073	alpha beta
HEK616_RS14990	COG2226	methyltransferase
HEK616_RS15000	COG0583	DNA-binding transcription factor activity
HEK616_RS15015	COG0366	Alpha amylase catalytic
HEK616_RS15030	COG1653	transport
HEK616_RS15035	COG3842	ATPase activity
HEK616_RS15040	COG1609	Transcriptional regulator
HEK616_RS15075	COG0667	Aldo Keto reductase
HEK616_RS15100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEK616_RS15135	COG0539	negative regulation of cytoplasmic translation
HEK616_RS15150	COG2205	protein histidine kinase activity
HEK616_RS15230	COG0640	Transcriptional regulator
HEK616_RS15240	COG1309	transcriptional regulator
HEK616_RS15250	COG0586	Pfam SNARE associated Golgi protein
HEK616_RS15255	COG4585	Histidine kinase
HEK616_RS15275	COG0697	spore germination
HEK616_RS15285	COG1131	(ABC) transporter
HEK616_RS15290	COG4585	Histidine kinase
HEK616_RS15295	COG2197	response regulator
HEK616_RS15310	COG4977	sequence-specific DNA binding
HEK616_RS15335	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS15345	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS15350	COG1024	Enoyl-CoA hydratase
HEK616_RS15355	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS15365	COG1309	transcriptional regulator
HEK616_RS15370	COG0183	Belongs to the thiolase family
HEK616_RS15405	COG2365	Tyrosine phosphatase family
HEK616_RS15425	COG1024	Enoyl-CoA hydratase
HEK616_RS15440	COG3971	2-oxopent-4-enoate hydratase activity
HEK616_RS15445	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HEK616_RS15470	COG0477	Major facilitator Superfamily
HEK616_RS15490	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS15495	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS15500	COG2267	carboxylic ester hydrolase activity
HEK616_RS15510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEK616_RS15515	COG2030	dehydratase
HEK616_RS15520	COG1053	succinate dehydrogenase
HEK616_RS15540	COG2072	flavoprotein involved in K transport
HEK616_RS15545	COG0657	acetylesterase activity
HEK616_RS15560	COG0702	epimerase
HEK616_RS15580	COG1846	Transcriptional regulator
HEK616_RS15605	COG3842	ATPase activity
HEK616_RS15610	COG1511	domain protein
HEK616_RS15615	COG1595	DNA-templated transcription, initiation
HEK616_RS15655	COG4941	Belongs to the sigma-70 factor family
HEK616_RS15660	COG3795	YCII-related domain
HEK616_RS15675	COG1595	DNA-templated transcription, initiation
HEK616_RS15720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEK616_RS15730	COG3835	regulator
HEK616_RS15745	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS15770	COG0504	CTP synthase activity
HEK616_RS15775	COG0583	DNA-binding transcription factor activity
HEK616_RS15780	COG4122	O-methyltransferase activity
HEK616_RS15820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEK616_RS15875	COG0019	diaminopimelate decarboxylase activity
HEK616_RS15895	COG0531	amino acid
HEK616_RS15915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEK616_RS15925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEK616_RS15930	COG4948	Mandelate Racemase Muconate Lactonizing
HEK616_RS15945	COG0747	negative chemotaxis
HEK616_RS15955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEK616_RS15965	COG0523	cobalamin synthesis protein
HEK616_RS15990	COG0667	Aldo Keto reductase
HEK616_RS15995	COG2226	methyltransferase
HEK616_RS16020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEK616_RS16035	COG2318	DinB family
HEK616_RS16070	COG0702	epimerase
HEK616_RS16095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS16100	COG3433	isochorismatase activity
HEK616_RS16100	COG1535	isochorismatase
HEK616_RS16135	COG1309	transcriptional regulator
HEK616_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS16160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEK616_RS16175	COG1063	alcohol dehydrogenase
HEK616_RS16195	COG1846	Transcriptional regulator
HEK616_RS16220	COG2197	response regulator
HEK616_RS16225	COG4585	Histidine kinase
HEK616_RS16230	COG1131	(ABC) transporter
HEK616_RS16255	COG0667	Aldo Keto reductase
HEK616_RS16280	COG2318	DinB family
HEK616_RS16320	COG1132	(ABC) transporter
HEK616_RS16330	COG3391	amine dehydrogenase activity
HEK616_RS16335	COG1309	transcriptional regulator
HEK616_RS16340	COG2267	carboxylic ester hydrolase activity
HEK616_RS16345	COG0604	alcohol dehydrogenase
HEK616_RS16345	COG3321	synthase
HEK616_RS16430	COG2814	Major facilitator Superfamily
HEK616_RS16485	COG1595	DNA-templated transcription, initiation
HEK616_RS16505	COG1309	transcriptional regulator
HEK616_RS16530	COG1309	transcriptional regulator
HEK616_RS16535	COG0604	alcohol dehydrogenase
HEK616_RS16550	COG0738	Major facilitator superfamily
HEK616_RS16560	COG1231	oxidoreductase activity
HEK616_RS16610	COG0583	DNA-binding transcription factor activity
HEK616_RS16690	COG2070	2-Nitropropane dioxygenase
HEK616_RS16780	COG0789	Transcriptional regulator
HEK616_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS16860	COG4585	Histidine kinase
HEK616_RS16865	COG2197	response regulator
HEK616_RS16890	COG0515	serine threonine protein kinase
HEK616_RS16895	COG3345	alpha-galactosidase
HEK616_RS16900	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEK616_RS16910	COG2226	methyltransferase
HEK616_RS16945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEK616_RS16955	COG0745	RESPONSE REGULATOR receiver
HEK616_RS16995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS17015	COG0596	Alpha beta hydrolase
HEK616_RS17020	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS17075	COG3511	phospholipase C
HEK616_RS17145	COG1595	DNA-templated transcription, initiation
HEK616_RS17150	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEK616_RS17160	COG2205	protein histidine kinase activity
HEK616_RS17165	COG0745	RESPONSE REGULATOR receiver
HEK616_RS17180	COG1136	(ABC) transporter
HEK616_RS17180	COG0577	efflux transmembrane transporter activity
HEK616_RS17185	COG0577	efflux transmembrane transporter activity
HEK616_RS17185	COG1136	(ABC) transporter
HEK616_RS17205	COG0596	Alpha beta hydrolase
HEK616_RS17285	COG5006	permease, DMT superfamily
HEK616_RS17320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HEK616_RS17325	COG1396	sequence-specific DNA binding
HEK616_RS17465	COG4977	sequence-specific DNA binding
HEK616_RS17500	COG3979	chitinase
HEK616_RS17565	COG3903	Transcriptional regulator
HEK616_RS17565	COG2197	response regulator
HEK616_RS17605	COG0667	Aldo Keto reductase
HEK616_RS17635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEK616_RS17650	COG1309	transcriptional regulator
HEK616_RS17685	COG1309	transcriptional regulator
HEK616_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS17725	COG1408	metallophosphoesterase
HEK616_RS17770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS17825	COG1476	TRANSCRIPTIONal
HEK616_RS17880	COG3409	Peptidoglycan-binding domain 1 protein
HEK616_RS17885	COG0300	oxidoreductase activity
HEK616_RS17940	COG1132	(ABC) transporter
HEK616_RS17955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEK616_RS17965	COG2205	protein histidine kinase activity
HEK616_RS17990	COG3384	dioxygenase
HEK616_RS18045	COG0745	RESPONSE REGULATOR receiver
HEK616_RS18055	COG0019	diaminopimelate decarboxylase activity
HEK616_RS18075	COG2205	protein histidine kinase activity
HEK616_RS18100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEK616_RS18120	COG0277	FAD linked oxidase domain protein
HEK616_RS18150	COG2814	Major facilitator Superfamily
HEK616_RS18155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEK616_RS18270	COG4249	Peptidase C14 caspase catalytic subunit p20
HEK616_RS18270	COG2319	Wd-40 repeat
HEK616_RS18325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEK616_RS18420	COG0477	Major facilitator Superfamily
HEK616_RS18450	COG0583	DNA-binding transcription factor activity
HEK616_RS18470	COG2197	response regulator
HEK616_RS18485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HEK616_RS18495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEK616_RS18520	COG2197	response regulator
HEK616_RS18530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEK616_RS18530	COG0574	Belongs to the PEP-utilizing enzyme family
HEK616_RS18545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEK616_RS18560	COG0596	Alpha beta hydrolase
HEK616_RS18610	COG0668	transmembrane transport
HEK616_RS18650	COG1309	transcriptional regulator
HEK616_RS18665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEK616_RS18675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEK616_RS18680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEK616_RS18725	COG0531	amino acid
HEK616_RS18740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEK616_RS18745	COG2318	DinB family
HEK616_RS18765	COG1309	transcriptional regulator
HEK616_RS18770	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS18835	COG0583	DNA-binding transcription factor activity
HEK616_RS18840	COG2340	Cysteine-rich secretory protein family
HEK616_RS18870	COG3655	Transcriptional regulator
HEK616_RS18910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEK616_RS18915	COG2364	Membrane
HEK616_RS18930	COG2259	Doxx family
HEK616_RS18935	COG2226	methyltransferase
HEK616_RS18960	COG0662	Cupin 2, conserved barrel domain protein
HEK616_RS19000	COG4221	oxidoreductase activity
HEK616_RS19015	COG1652	LysM domain
HEK616_RS19025	COG0339	signal peptide processing
HEK616_RS19035	COG0583	DNA-binding transcription factor activity
HEK616_RS19080	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HEK616_RS19085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEK616_RS19125	COG2124	cytochrome p450
HEK616_RS19155	COG3290	protein histidine kinase activity
HEK616_RS19175	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS19195	COG1793	dna ligase
HEK616_RS19210	COG0531	amino acid
HEK616_RS19235	COG2837	iron assimilation
HEK616_RS19240	COG0309	Hydrogenase expression formation protein (HypE)
HEK616_RS19250	COG0298	carbon dioxide binding
HEK616_RS19255	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEK616_RS19260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEK616_RS19265	COG0375	protein maturation
HEK616_RS19295	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEK616_RS19315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEK616_RS19325	COG0477	Major facilitator Superfamily
HEK616_RS19340	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS19345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEK616_RS19355	COG2124	cytochrome p450
HEK616_RS19360	COG2084	Dehydrogenase
HEK616_RS19365	COG3622	Belongs to the hyi family
HEK616_RS19370	COG3960	tartronate-semialdehyde synthase activity
HEK616_RS19380	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS19390	COG0242	peptide deformylase activity
HEK616_RS19400	COG3442	glutamine amidotransferase
HEK616_RS19405	COG0205	6-phosphofructokinase activity
HEK616_RS19430	COG0693	protein deglycase activity
HEK616_RS19450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEK616_RS19480	COG0829	nickel cation binding
HEK616_RS19485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEK616_RS19490	COG0830	nickel cation binding
HEK616_RS19495	COG0804	urea catabolic process
HEK616_RS19500	COG0832	Belongs to the urease beta subunit family
HEK616_RS19505	COG0831	urea catabolic process
HEK616_RS19520	COG0740	serine-type endopeptidase activity
HEK616_RS19545	COG0156	8-amino-7-oxononanoate synthase activity
HEK616_RS19550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEK616_RS19555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEK616_RS19560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEK616_RS19575	COG2226	methyltransferase
HEK616_RS19625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEK616_RS19635	COG3511	phospholipase C
HEK616_RS19655	COG4585	Histidine kinase
HEK616_RS19660	COG2197	response regulator
HEK616_RS19665	COG1940	carbohydrate kinase activity
HEK616_RS19670	COG2188	Transcriptional regulator
HEK616_RS19675	COG1595	DNA-templated transcription, initiation
HEK616_RS19685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEK616_RS19710	COG1522	sequence-specific DNA binding
HEK616_RS19715	COG0419	ATPase involved in DNA repair
HEK616_RS19720	COG0420	3'-5' exonuclease activity
HEK616_RS19735	COG0531	amino acid
HEK616_RS19740	COG1739	Uncharacterized protein family UPF0029
HEK616_RS19750	COG1832	CoA-binding protein
HEK616_RS19850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEK616_RS19850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEK616_RS20165	COG0110	maltose O-acetyltransferase activity
HEK616_RS20180	COG2124	cytochrome p450
HEK616_RS20250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEK616_RS20285	COG2770	Histidine kinase
HEK616_RS20285	COG2208	phosphoserine phosphatase activity
HEK616_RS20320	COG1175	transmembrane transport
HEK616_RS20325	COG0395	ABC-type sugar transport system, permease component
HEK616_RS20330	COG2723	6-phospho-beta-galactosidase activity
HEK616_RS20335	COG1764	response to oxidative stress
HEK616_RS20340	COG1846	Transcriptional regulator
HEK616_RS20385	COG0739	heme binding
HEK616_RS20395	COG0702	epimerase
HEK616_RS20400	COG1609	Transcriptional regulator
HEK616_RS20405	COG1653	transport
HEK616_RS20410	COG1175	transmembrane transport
HEK616_RS20415	COG0395	ABC-type sugar transport system, permease component
HEK616_RS20455	COG1278	Cold shock
HEK616_RS20460	COG1686	Belongs to the peptidase S11 family
HEK616_RS20480	COG1793	dna ligase
HEK616_RS20480	COG3285	dna ligase
HEK616_RS20485	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEK616_RS20495	COG3012	SEC-C Motif Domain Protein
HEK616_RS20515	COG2364	Membrane
HEK616_RS20525	COG2270	Major facilitator Superfamily
HEK616_RS20540	COG1216	Glycosyl transferase, family 2
HEK616_RS20550	COG1228	amidohydrolase
HEK616_RS20575	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS20585	COG1309	transcriptional regulator
HEK616_RS20605	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS20610	COG3629	intracellular signal transduction
HEK616_RS20610	COG3903	Transcriptional regulator
HEK616_RS20655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS20660	COG1309	transcriptional regulator
HEK616_RS20685	COG1017	nitric oxide dioxygenase activity
HEK616_RS20685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEK616_RS20690	COG1959	2 iron, 2 sulfur cluster binding
HEK616_RS20715	COG1609	Transcriptional regulator
HEK616_RS20720	COG1957	nucleoside hydrolase
HEK616_RS20725	COG0477	Major facilitator Superfamily
HEK616_RS20755	COG0243	molybdopterin cofactor binding
HEK616_RS20755	COG3383	formate dehydrogenase (NAD+) activity
HEK616_RS20760	COG0437	4 iron, 4 sulfur cluster binding
HEK616_RS20800	COG2837	iron assimilation
HEK616_RS20925	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEK616_RS20930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEK616_RS20935	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEK616_RS20955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEK616_RS20960	COG1309	transcriptional regulator
HEK616_RS20985	COG1902	pentaerythritol trinitrate reductase activity
HEK616_RS20995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEK616_RS21005	COG2971	BadF BadG BcrA BcrD
HEK616_RS21035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEK616_RS21040	COG4213	ABC transporter substrate-binding protein
HEK616_RS21055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEK616_RS21060	COG0443	Heat shock 70 kDa protein
HEK616_RS21065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEK616_RS21080	COG1254	Belongs to the acylphosphatase family
HEK616_RS21105	COG0477	Major facilitator Superfamily
HEK616_RS21115	COG3290	protein histidine kinase activity
HEK616_RS21120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS21130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEK616_RS21135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEK616_RS21140	COG2080	2 iron, 2 sulfur cluster binding
HEK616_RS21160	COG0484	heat shock protein binding
HEK616_RS21165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEK616_RS21170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEK616_RS21170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEK616_RS21175	COG0412	Dienelactone hydrolase
HEK616_RS21205	COG2080	2 iron, 2 sulfur cluster binding
HEK616_RS21210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEK616_RS21215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEK616_RS21310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEK616_RS21330	COG0477	Major facilitator Superfamily
HEK616_RS21355	COG1113	amino acid transport
HEK616_RS21380	COG2018	Roadblock/LC7 domain
HEK616_RS21400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEK616_RS21415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS21420	COG0492	ferredoxin-NADP+ reductase activity
HEK616_RS21425	COG0477	Major facilitator Superfamily
HEK616_RS21430	COG0247	lactate metabolic process
HEK616_RS21435	COG1139	Iron-sulfur cluster binding protein
HEK616_RS21440	COG1556	Lactate utilization protein
HEK616_RS21470	COG1132	(ABC) transporter
HEK616_RS21505	COG1132	(ABC) transporter
HEK616_RS21510	COG1132	(ABC) transporter
HEK616_RS21525	COG1946	Acyl-CoA thioesterase
HEK616_RS21535	COG2018	Roadblock/LC7 domain
HEK616_RS21575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEK616_RS21595	COG0431	NADPH-dependent FMN reductase
HEK616_RS21605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS21615	COG2040	homocysteine
HEK616_RS21625	COG3458	cephalosporin-C deacetylase activity
HEK616_RS21630	COG2115	Belongs to the xylose isomerase family
HEK616_RS21635	COG1070	Carbohydrate kinase
HEK616_RS21640	COG1940	carbohydrate kinase activity
HEK616_RS21645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEK616_RS21650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEK616_RS21650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEK616_RS21655	COG3023	N-Acetylmuramoyl-L-alanine amidase
HEK616_RS21685	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEK616_RS21685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEK616_RS21690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEK616_RS21695	COG0588	phosphoglycerate mutase activity
HEK616_RS21700	COG1070	Carbohydrate kinase
HEK616_RS21705	COG1070	Carbohydrate kinase
HEK616_RS21710	COG2814	Major facilitator Superfamily
HEK616_RS21715	COG1349	DNA-binding transcription factor activity
HEK616_RS21720	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS21725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEK616_RS21735	COG1024	Enoyl-CoA hydratase
HEK616_RS21740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEK616_RS21745	COG0583	DNA-binding transcription factor activity
HEK616_RS21780	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS21785	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS21820	COG3572	ergothioneine biosynthetic process
HEK616_RS21825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEK616_RS21835	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEK616_RS21880	COG3360	Dodecin
HEK616_RS21885	COG0531	amino acid
HEK616_RS21900	COG3537	Alpha-1,2-mannosidase
HEK616_RS21945	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS21950	COG2133	pyrroloquinoline quinone binding
HEK616_RS21950	COG5183	chlorophyll binding
HEK616_RS21970	COG2706	6-phosphogluconolactonase activity
HEK616_RS21975	COG1113	amino acid transport
HEK616_RS21980	COG2205	protein histidine kinase activity
HEK616_RS21990	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS22025	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS22035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEK616_RS22045	COG0747	negative chemotaxis
HEK616_RS22050	COG1940	carbohydrate kinase activity
HEK616_RS22070	COG0174	glutamine synthetase
HEK616_RS22085	COG3246	L-lysine catabolic process to acetate
HEK616_RS22090	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEK616_RS22110	COG1686	Belongs to the peptidase S11 family
HEK616_RS22115	COG2124	cytochrome p450
HEK616_RS22145	COG3959	Transketolase, thiamine diphosphate binding domain
HEK616_RS22150	COG3958	Transketolase
HEK616_RS22160	COG1228	amidohydrolase
HEK616_RS22165	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS22185	COG2018	Roadblock/LC7 domain
HEK616_RS22195	COG1191	sigma factor activity
HEK616_RS22230	COG0640	Transcriptional regulator
HEK616_RS22235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEK616_RS22240	COG0477	Major facilitator Superfamily
HEK616_RS22270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEK616_RS22295	COG2755	lipolytic protein G-D-S-L family
HEK616_RS22300	COG2365	Tyrosine phosphatase family
HEK616_RS22315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEK616_RS22330	COG1657	PFAM Prenyltransferase squalene oxidase
HEK616_RS22340	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HEK616_RS22350	COG1562	ergosterol biosynthetic process
HEK616_RS22355	COG1134	teichoic acid transport
HEK616_RS22390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEK616_RS22410	COG1024	Enoyl-CoA hydratase
HEK616_RS22420	COG4977	sequence-specific DNA binding
HEK616_RS22430	COG2183	response to ionizing radiation
HEK616_RS22455	COG2936	dipeptidyl-peptidase activity
HEK616_RS22470	COG3568	Endonuclease Exonuclease Phosphatase
HEK616_RS22480	COG1113	amino acid transport
HEK616_RS22495	COG1024	Enoyl-CoA hydratase
HEK616_RS22495	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEK616_RS22500	COG0183	Belongs to the thiolase family
HEK616_RS22505	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS22515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEK616_RS22525	COG1285	pathogenesis
HEK616_RS22535	COG3268	Saccharopine dehydrogenase
HEK616_RS22540	COG1515	deoxyribonuclease V activity
HEK616_RS22545	COG0154	amidase activity
HEK616_RS22555	COG2814	Major facilitator Superfamily
HEK616_RS22560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEK616_RS22570	COG1349	DNA-binding transcription factor activity
HEK616_RS22580	COG1309	transcriptional regulator
HEK616_RS22585	COG1289	transmembrane transporter activity
HEK616_RS22585	COG1289	transmembrane transporter activity
HEK616_RS22590	COG1846	Transcriptional regulator
HEK616_RS22605	COG3226	Transcriptional regulator
HEK616_RS22625	COG0726	polysaccharide deacetylase
HEK616_RS22630	COG0745	RESPONSE REGULATOR receiver
HEK616_RS22635	COG2205	protein histidine kinase activity
HEK616_RS22675	COG0583	DNA-binding transcription factor activity
HEK616_RS22720	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS22725	COG0531	amino acid
HEK616_RS22740	COG0287	Prephenate dehydrogenase
HEK616_RS22740	COG1605	Chorismate mutase
HEK616_RS22745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HEK616_RS22770	COG0583	DNA-binding transcription factor activity
HEK616_RS22785	COG0656	L-ascorbic acid biosynthetic process
HEK616_RS22805	COG1295	ribonuclease BN
HEK616_RS22810	COG2154	pterin-4-alpha-carbinolamine dehydratase
HEK616_RS22830	COG0531	amino acid
HEK616_RS22890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEK616_RS22920	COG2124	cytochrome p450
HEK616_RS22940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEK616_RS22945	COG2362	D-Aminopeptidase
HEK616_RS22965	COG2814	Major facilitator Superfamily
HEK616_RS22990	COG0456	acetyltransferase
HEK616_RS22990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEK616_RS23000	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEK616_RS23015	COG0604	alcohol dehydrogenase
HEK616_RS23020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEK616_RS23020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEK616_RS23025	COG2301	Belongs to the HpcH HpaI aldolase family
HEK616_RS23035	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS23040	COG0688	phosphatidylethanolamine metabolic process
HEK616_RS23050	COG1929	Belongs to the glycerate kinase type-1 family
HEK616_RS23085	COG2267	carboxylic ester hydrolase activity
HEK616_RS23095	COG0702	epimerase
HEK616_RS23105	COG2867	negative regulation of translational initiation
HEK616_RS23150	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HEK616_RS23190	COG4829	muconolactone delta-isomerase
HEK616_RS23195	COG4638	Rieske (2fe-2S)
HEK616_RS23225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEK616_RS23230	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS23245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HEK616_RS23255	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEK616_RS23270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS23285	COG3510	cephalosporin hydroxylase
HEK616_RS23300	COG4585	Histidine kinase
HEK616_RS23305	COG2197	response regulator
HEK616_RS23310	COG3629	intracellular signal transduction
HEK616_RS23310	COG3903	Transcriptional regulator
HEK616_RS23330	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEK616_RS23340	COG0483	inositol monophosphate 1-phosphatase activity
HEK616_RS23350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEK616_RS23355	COG0095	Lipoate-protein ligase
HEK616_RS23360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS23390	COG1476	TRANSCRIPTIONal
HEK616_RS23420	COG0531	amino acid
HEK616_RS23445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEK616_RS23460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEK616_RS23475	COG0477	Major facilitator Superfamily
HEK616_RS23480	COG1335	isochorismatase
HEK616_RS23495	COG0387	Pfam Sodium calcium exchanger
HEK616_RS23500	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS23515	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS23525	COG0435	Glutathione S-transferase
HEK616_RS23535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEK616_RS23550	COG2226	methyltransferase
HEK616_RS23570	COG0765	amino acid transport
HEK616_RS23575	COG0765	amino acid transport
HEK616_RS23580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEK616_RS23585	COG1126	abc transporter atp-binding protein
HEK616_RS23610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEK616_RS23655	COG2197	response regulator
HEK616_RS23665	COG0464	growth
HEK616_RS23750	COG1940	carbohydrate kinase activity
HEK616_RS23760	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEK616_RS23775	COG2188	Transcriptional regulator
HEK616_RS23785	COG0583	DNA-binding transcription factor activity
HEK616_RS23810	COG0800	Aldolase
HEK616_RS23845	COG4266	Belongs to the allantoicase family
HEK616_RS23850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEK616_RS23855	COG1953	Uracil, thiamine, allantoin
HEK616_RS23865	COG1414	Transcriptional regulator
HEK616_RS23890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEK616_RS23910	COG2233	PERMEase
HEK616_RS23920	COG2233	PERMEase
HEK616_RS23930	COG2351	hydroxyisourate hydrolase activity
HEK616_RS23950	COG3622	Belongs to the hyi family
HEK616_RS23955	COG2084	Dehydrogenase
HEK616_RS23960	COG0028	Belongs to the TPP enzyme family
HEK616_RS23965	COG0753	catalase activity
HEK616_RS23990	COG2315	Protein conserved in bacteria
HEK616_RS24005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEK616_RS24010	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS24030	COG0604	alcohol dehydrogenase
HEK616_RS24030	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS24030	COG3321	synthase
HEK616_RS24035	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS24045	COG0583	DNA-binding transcription factor activity
HEK616_RS24060	COG2252	PERMEase
HEK616_RS24065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEK616_RS24095	COG1802	Transcriptional regulator
HEK616_RS24120	COG0028	Belongs to the TPP enzyme family
HEK616_RS24135	COG1162	GTPase activity
HEK616_RS24145	COG0531	amino acid
HEK616_RS24205	COG1131	(ABC) transporter
HEK616_RS24205	COG1716	ATPase activity
HEK616_RS24205	COG0842	Transport permease protein
HEK616_RS24230	COG1376	ErfK ybiS ycfS ynhG family protein
HEK616_RS24235	COG0667	Aldo Keto reductase
HEK616_RS24240	COG3511	phospholipase C
HEK616_RS24250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEK616_RS24270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEK616_RS24275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEK616_RS24280	COG2080	2 iron, 2 sulfur cluster binding
HEK616_RS24305	COG1846	Transcriptional regulator
HEK616_RS24360	COG0596	Alpha beta hydrolase
HEK616_RS24365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEK616_RS24370	COG3485	protocatechuate 3,4-dioxygenase
HEK616_RS24375	COG3485	protocatechuate 3,4-dioxygenase
HEK616_RS24385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HEK616_RS24395	COG1414	Transcriptional regulator
HEK616_RS24415	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS24455	COG0175	sulfate reduction
HEK616_RS24460	COG0529	Catalyzes the synthesis of activated sulfate
HEK616_RS24480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HEK616_RS24485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEK616_RS24495	COG0366	Alpha amylase catalytic
HEK616_RS24505	COG1609	Transcriptional regulator
HEK616_RS24510	COG1442	glycosyl transferase family 8
HEK616_RS24510	COG1216	Glycosyl transferase, family 2
HEK616_RS24520	COG0477	Major facilitator Superfamily
HEK616_RS24560	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS24600	COG0583	DNA-binding transcription factor activity
HEK616_RS24605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEK616_RS24625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEK616_RS24635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEK616_RS24670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEK616_RS24675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEK616_RS24680	COG2197	response regulator
HEK616_RS24685	COG4585	Histidine kinase
HEK616_RS24695	COG1136	(ABC) transporter
HEK616_RS24730	COG1116	anion transmembrane transporter activity
HEK616_RS24740	COG1280	lysine exporter protein (LysE YggA)
HEK616_RS24765	COG3253	May function as heme-dependent peroxidase
HEK616_RS24770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HEK616_RS24780	COG0183	Belongs to the thiolase family
HEK616_RS24785	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEK616_RS24790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEK616_RS24805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEK616_RS24815	COG0183	Belongs to the thiolase family
HEK616_RS24820	COG1024	Enoyl-CoA hydratase
HEK616_RS24820	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEK616_RS24840	COG0531	amino acid
HEK616_RS24845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEK616_RS24850	COG4214	carbohydrate transport
HEK616_RS24860	COG4213	ABC transporter substrate-binding protein
HEK616_RS24865	COG1940	carbohydrate kinase activity
HEK616_RS24870	COG0395	ABC-type sugar transport system, permease component
HEK616_RS24875	COG1175	transmembrane transport
HEK616_RS24880	COG1653	transport
HEK616_RS24890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HEK616_RS24895	COG1595	DNA-templated transcription, initiation
HEK616_RS24900	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEK616_RS24900	COG1902	pentaerythritol trinitrate reductase activity
HEK616_RS24905	COG1595	DNA-templated transcription, initiation
HEK616_RS24930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEK616_RS24955	COG0546	phosphoglycolate phosphatase activity
HEK616_RS24980	COG1024	Enoyl-CoA hydratase
HEK616_RS24995	COG0531	amino acid
HEK616_RS25000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEK616_RS25015	COG4977	sequence-specific DNA binding
HEK616_RS25020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEK616_RS25050	COG1799	cell septum assembly
HEK616_RS25055	COG0598	Magnesium transport protein CorA
HEK616_RS25075	COG1846	Transcriptional regulator
HEK616_RS25100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEK616_RS25110	COG0010	Belongs to the arginase family
HEK616_RS25120	COG1309	transcriptional regulator
HEK616_RS25130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEK616_RS25135	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEK616_RS25140	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEK616_RS25145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEK616_RS25145	COG0235	Class ii aldolase
HEK616_RS25150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS25155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS25160	COG3251	PFAM MbtH domain protein
HEK616_RS25185	COG2175	clavaminate synthase activity
HEK616_RS25190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEK616_RS25195	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HEK616_RS25210	COG2124	cytochrome p450
HEK616_RS25215	COG3424	synthase
HEK616_RS25255	COG2814	Major facilitator Superfamily
HEK616_RS25260	COG0384	phenazine biosynthesis protein PhzF
HEK616_RS25295	COG2197	response regulator
HEK616_RS25325	COG0210	DNA helicase
HEK616_RS25335	COG0515	serine threonine protein kinase
HEK616_RS25385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEK616_RS25390	COG0531	amino acid
HEK616_RS25400	COG0569	domain protein
HEK616_RS25445	COG1136	(ABC) transporter
HEK616_RS25445	COG0577	efflux transmembrane transporter activity
HEK616_RS25455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEK616_RS25460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEK616_RS25465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEK616_RS25480	COG0756	dUTP diphosphatase activity
HEK616_RS25505	COG2205	protein histidine kinase activity
HEK616_RS25510	COG0745	RESPONSE REGULATOR receiver
HEK616_RS25520	COG0483	inositol monophosphate 1-phosphatase activity
HEK616_RS25525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEK616_RS25575	COG1435	thymidine kinase activity
HEK616_RS25595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEK616_RS25600	COG1802	Transcriptional regulator
HEK616_RS25615	COG0612	Peptidase, M16
HEK616_RS25620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEK616_RS25630	COG0372	Belongs to the citrate synthase family
HEK616_RS25645	COG3290	protein histidine kinase activity
HEK616_RS25650	COG4565	transcriptional regulatory protein
HEK616_RS25655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEK616_RS25665	COG2197	response regulator
HEK616_RS25670	COG4585	Histidine kinase
HEK616_RS25680	COG0187	DNA topoisomerase II activity
HEK616_RS25695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEK616_RS25700	COG2186	Transcriptional regulator
HEK616_RS25735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEK616_RS25745	COG0588	phosphoglycerate mutase activity
HEK616_RS25750	COG0488	(ABC) transporter
HEK616_RS25765	COG0154	amidase activity
HEK616_RS25770	COG3226	Transcriptional regulator
HEK616_RS25790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEK616_RS25795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEK616_RS25800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEK616_RS25835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEK616_RS25845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEK616_RS25850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEK616_RS25860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEK616_RS25875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEK616_RS25890	COG1278	Cold shock
HEK616_RS25895	COG2205	protein histidine kinase activity
HEK616_RS25900	COG0745	RESPONSE REGULATOR receiver
HEK616_RS25905	COG1126	abc transporter atp-binding protein
HEK616_RS25910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEK616_RS25915	COG0765	amino acid transport
HEK616_RS25920	COG0765	amino acid transport
HEK616_RS25925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS25950	COG0628	permease
HEK616_RS25980	COG1201	RNA secondary structure unwinding
HEK616_RS25985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEK616_RS26000	COG0783	Belongs to the Dps family
HEK616_RS26005	COG1396	sequence-specific DNA binding
HEK616_RS26010	COG1546	Belongs to the CinA family
HEK616_RS26010	COG1058	Belongs to the CinA family
HEK616_RS26020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEK616_RS26030	COG1674	ftsk spoiiie
HEK616_RS26040	COG2205	protein histidine kinase activity
HEK616_RS26040	COG3850	Histidine kinase
HEK616_RS26040	COG4999	Histidine kinase
HEK616_RS26040	COG3437	response regulator, receiver
HEK616_RS26045	COG2770	Histidine kinase
HEK616_RS26045	COG2208	phosphoserine phosphatase activity
HEK616_RS26080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEK616_RS26085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEK616_RS26090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HEK616_RS26110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HEK616_RS26115	COG0612	Peptidase, M16
HEK616_RS26120	COG1185	polyribonucleotide nucleotidyltransferase activity
HEK616_RS26125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEK616_RS26135	COG1674	ftsk spoiiie
HEK616_RS26200	COG1404	Belongs to the peptidase S8 family
HEK616_RS26215	COG3266	domain, Protein
HEK616_RS26230	COG0455	bacterial-type flagellum organization
HEK616_RS26245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEK616_RS26250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEK616_RS26255	COG1550	Protein conserved in bacteria
HEK616_RS26260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HEK616_RS26275	COG0779	Required for maturation of 30S ribosomal subunits
HEK616_RS26290	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HEK616_RS26295	COG0442	prolyl-tRNA aminoacylation
HEK616_RS26310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEK616_RS26315	COG0750	zinc metalloprotease
HEK616_RS26320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEK616_RS26330	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS26355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEK616_RS26360	COG1177	transmembrane transport
HEK616_RS26365	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEK616_RS26370	COG3842	ATPase activity
HEK616_RS26390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEK616_RS26405	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS26415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEK616_RS26420	COG1136	(ABC) transporter
HEK616_RS26450	COG4585	Histidine kinase
HEK616_RS26455	COG2197	response regulator
HEK616_RS26460	COG3842	ATPase activity
HEK616_RS26465	COG4208	sulfate ABC transporter
HEK616_RS26475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEK616_RS26505	COG0575	Belongs to the CDS family
HEK616_RS26510	COG0233	cytoplasmic translational termination
HEK616_RS26515	COG0528	UMP kinase activity
HEK616_RS26520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEK616_RS26525	COG0052	Belongs to the universal ribosomal protein uS2 family
HEK616_RS26540	COG1191	sigma factor activity
HEK616_RS26555	COG0792	nuclease activity
HEK616_RS26570	COG0681	Belongs to the peptidase S26 family
HEK616_RS26575	COG0681	Belongs to the peptidase S26 family
HEK616_RS26590	COG0335	large ribosomal subunit rRNA binding
HEK616_RS26595	COG0336	Belongs to the RNA methyltransferase TrmD family
HEK616_RS26600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEK616_RS26605	COG1837	Belongs to the UPF0109 family
HEK616_RS26610	COG0228	four-way junction DNA binding
HEK616_RS26630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HEK616_RS26660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEK616_RS26680	COG0477	Major facilitator Superfamily
HEK616_RS26685	COG1196	nuclear chromosome segregation
HEK616_RS26695	COG1254	Belongs to the acylphosphatase family
HEK616_RS26710	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEK616_RS26715	COG1733	regulation of RNA biosynthetic process
HEK616_RS26720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEK616_RS26725	COG0571	ribonuclease III activity
HEK616_RS26730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HEK616_RS26740	COG2801	Transposase and inactivated derivatives
HEK616_RS26740	COG3415	Transposase
HEK616_RS26750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEK616_RS26755	COG0742	ribosomal rna small subunit methyltransferase
HEK616_RS26765	COG1461	Dihydroxyacetone kinase
HEK616_RS26770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEK616_RS26775	COG0351	phosphomethylpyrimidine kinase
HEK616_RS26795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEK616_RS26800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEK616_RS26810	COG1920	GTP binding
HEK616_RS26820	COG0776	regulation of translation
HEK616_RS26830	COG0066	3-isopropylmalate dehydratase activity
HEK616_RS26835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEK616_RS26840	COG1414	Transcriptional regulator
HEK616_RS26880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEK616_RS26885	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEK616_RS26900	COG2018	Roadblock/LC7 domain
HEK616_RS26920	COG2018	Roadblock/LC7 domain
HEK616_RS26945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEK616_RS26955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEK616_RS26965	COG0477	Major facilitator Superfamily
HEK616_RS26970	COG1309	transcriptional regulator
HEK616_RS26975	COG2957	Belongs to the agmatine deiminase family
HEK616_RS26980	COG0804	urea catabolic process
HEK616_RS26985	COG0832	Belongs to the urease beta subunit family
HEK616_RS26985	COG0831	urea catabolic process
HEK616_RS26995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEK616_RS27000	COG0473	3-isopropylmalate dehydrogenase activity
HEK616_RS27020	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS27025	COG0506	proline dehydrogenase activity
HEK616_RS27050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEK616_RS27055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEK616_RS27060	COG0440	acetolactate synthase activity
HEK616_RS27070	COG3300	MHYT domain
HEK616_RS27070	COG5001	Diguanylate cyclase
HEK616_RS27080	COG0667	Aldo Keto reductase
HEK616_RS27085	COG2133	pyrroloquinoline quinone binding
HEK616_RS27100	COG1672	PFAM Archaeal ATPase
HEK616_RS27100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEK616_RS27115	COG2409	Drug exporters of the RND superfamily
HEK616_RS27155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEK616_RS27165	COG0154	amidase activity
HEK616_RS27170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEK616_RS27180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEK616_RS27190	COG0477	Major facilitator Superfamily
HEK616_RS27200	COG4221	oxidoreductase activity
HEK616_RS27210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEK616_RS27215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEK616_RS27225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEK616_RS27235	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS27255	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS27275	COG2814	Major facilitator Superfamily
HEK616_RS27315	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS27340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEK616_RS27350	COG2264	protein methyltransferase activity
HEK616_RS27400	COG0482	sulfurtransferase activity
HEK616_RS27415	COG0596	Alpha beta hydrolase
HEK616_RS27420	COG3903	Transcriptional regulator
HEK616_RS27420	COG3629	intracellular signal transduction
HEK616_RS27445	COG2860	membrane
HEK616_RS27450	COG0308	aminopeptidase N
HEK616_RS27455	COG4608	Belongs to the ABC transporter superfamily
HEK616_RS27460	COG0444	Belongs to the ABC transporter superfamily
HEK616_RS27470	COG0747	negative chemotaxis
HEK616_RS27475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEK616_RS27495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEK616_RS27500	COG0509	glycine decarboxylation via glycine cleavage system
HEK616_RS27505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEK616_RS27510	COG0531	amino acid
HEK616_RS27515	COG1760	l-serine dehydratase
HEK616_RS27525	COG0671	phosphoesterase, PA-phosphatase related
HEK616_RS27535	COG0586	Pfam SNARE associated Golgi protein
HEK616_RS27555	COG0745	RESPONSE REGULATOR receiver
HEK616_RS27560	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS27570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEK616_RS27580	COG4232	protein-disulfide reductase activity
HEK616_RS27585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEK616_RS27585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEK616_RS27605	COG1376	ErfK ybiS ycfS ynhG family protein
HEK616_RS27610	COG1376	ErfK ybiS ycfS ynhG family protein
HEK616_RS27620	COG1132	(ABC) transporter
HEK616_RS27625	COG1132	(ABC) transporter
HEK616_RS27630	COG1132	(ABC) transporter
HEK616_RS27635	COG1132	(ABC) transporter
HEK616_RS27660	COG0366	Alpha amylase catalytic
HEK616_RS27665	COG0366	Alpha amylase catalytic
HEK616_RS27675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEK616_RS27680	COG1301	dicarboxylic acid transport
HEK616_RS27685	COG3290	protein histidine kinase activity
HEK616_RS27690	COG4565	transcriptional regulatory protein
HEK616_RS27705	COG0395	ABC-type sugar transport system, permease component
HEK616_RS27715	COG1136	(ABC) transporter
HEK616_RS27715	COG0577	efflux transmembrane transporter activity
HEK616_RS27720	COG0577	efflux transmembrane transporter activity
HEK616_RS27720	COG1136	(ABC) transporter
HEK616_RS27725	COG0205	6-phosphofructokinase activity
HEK616_RS27730	COG0280	phosphate acetyltransferase
HEK616_RS27730	COG0857	belongs to the CobB CobQ family
HEK616_RS27735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEK616_RS27775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEK616_RS27810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEK616_RS27810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEK616_RS27870	COG0745	RESPONSE REGULATOR receiver
HEK616_RS27885	COG0183	Belongs to the thiolase family
HEK616_RS27940	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HEK616_RS27955	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEK616_RS27985	COG3850	Histidine kinase
HEK616_RS27990	COG2197	response regulator
HEK616_RS27995	COG3415	Transposase
HEK616_RS27995	COG2801	Transposase and inactivated derivatives
HEK616_RS28005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEK616_RS28010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEK616_RS28015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEK616_RS28020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEK616_RS28025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEK616_RS28030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEK616_RS28035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEK616_RS28055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEK616_RS28060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEK616_RS28070	COG2890	protein-(glutamine-N5) methyltransferase activity
HEK616_RS28075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEK616_RS28080	COG0254	rRNA binding
HEK616_RS28095	COG0083	homoserine kinase activity
HEK616_RS28100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEK616_RS28105	COG0460	homoserine dehydrogenase
HEK616_RS28110	COG0019	diaminopimelate decarboxylase activity
HEK616_RS28115	COG0018	arginyl-trna synthetase
HEK616_RS28130	COG2124	cytochrome p450
HEK616_RS28160	COG1119	ATPase activity
HEK616_RS28240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEK616_RS28245	COG1357	PFAM Pentapeptide repeats (8 copies)
HEK616_RS28270	COG0745	RESPONSE REGULATOR receiver
HEK616_RS28275	COG2205	protein histidine kinase activity
HEK616_RS28280	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEK616_RS28280	COG0567	Dehydrogenase, E1 component
HEK616_RS28315	COG2255	four-way junction helicase activity
HEK616_RS28350	COG0604	alcohol dehydrogenase
HEK616_RS28355	COG0281	malic enzyme
HEK616_RS28365	COG0765	amino acid transport
HEK616_RS28370	COG1126	abc transporter atp-binding protein
HEK616_RS28375	COG4106	trans-aconitate 2-methyltransferase activity
HEK616_RS28395	COG0583	DNA-binding transcription factor activity
HEK616_RS28405	COG2186	Transcriptional regulator
HEK616_RS28410	COG2807	transmembrane transport
HEK616_RS28415	COG0598	Magnesium transport protein CorA
HEK616_RS28420	COG0477	Major facilitator Superfamily
HEK616_RS28435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEK616_RS28450	COG2066	Belongs to the glutaminase family
HEK616_RS28505	COG1597	lipid kinase activity
HEK616_RS28520	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS28525	COG0363	glucosamine-6-phosphate deaminase activity
HEK616_RS28530	COG1472	Belongs to the glycosyl hydrolase 3 family
HEK616_RS28535	COG0395	ABC-type sugar transport system, permease component
HEK616_RS28540	COG1175	transmembrane transport
HEK616_RS28545	COG2182	Extracellular solute-binding protein
HEK616_RS28550	COG2188	Transcriptional regulator
HEK616_RS28575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEK616_RS28580	COG0242	peptide deformylase activity
HEK616_RS28590	COG2199	diguanylate cyclase activity
HEK616_RS28590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HEK616_RS28600	COG5662	AntiSigma factor
HEK616_RS28605	COG1595	DNA-templated transcription, initiation
HEK616_RS28610	COG1396	sequence-specific DNA binding
HEK616_RS28610	COG3800	Transcriptional regulator
HEK616_RS28620	COG2135	peptidase activity
HEK616_RS28630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEK616_RS28640	COG2076	Multidrug Resistance protein
HEK616_RS28650	COG0483	inositol monophosphate 1-phosphatase activity
HEK616_RS28660	COG0753	catalase activity
HEK616_RS28685	COG1615	UPF0182 protein
HEK616_RS28695	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEK616_RS28750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEK616_RS28780	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS28860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEK616_RS28875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEK616_RS28875	COG0596	Alpha beta hydrolase
HEK616_RS28920	COG1432	Conserved Protein
HEK616_RS28930	COG2095	MarC family integral membrane protein
HEK616_RS28935	COG0613	PHP domain protein
HEK616_RS28945	COG2814	Major facilitator Superfamily
HEK616_RS28955	COG0598	Magnesium transport protein CorA
HEK616_RS28990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEK616_RS28995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEK616_RS29005	COG1595	DNA-templated transcription, initiation
HEK616_RS29020	COG1024	Enoyl-CoA hydratase
HEK616_RS29025	COG0519	Catalyzes the synthesis of GMP from XMP
HEK616_RS29035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEK616_RS29040	COG1611	Belongs to the LOG family
HEK616_RS29045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEK616_RS29085	COG2197	response regulator
HEK616_RS29090	COG4585	Histidine kinase
HEK616_RS29100	COG1131	(ABC) transporter
HEK616_RS29115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEK616_RS29135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEK616_RS29140	COG4166	transmembrane transport
HEK616_RS29155	COG4608	Belongs to the ABC transporter superfamily
HEK616_RS29160	COG0789	Transcriptional regulator
HEK616_RS29165	COG4608	Belongs to the ABC transporter superfamily
HEK616_RS29170	COG0444	Belongs to the ABC transporter superfamily
HEK616_RS29175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEK616_RS29180	COG0601	transmembrane transport
HEK616_RS29185	COG4166	transmembrane transport
HEK616_RS29190	COG1217	gtp-binding protein TYPA
HEK616_RS29210	COG1053	succinate dehydrogenase
HEK616_RS29225	COG0402	S-adenosylhomocysteine deaminase activity
HEK616_RS29250	COG0531	amino acid
HEK616_RS29275	COG1414	Transcriptional regulator
HEK616_RS29280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEK616_RS29335	COG0012	GTP binding
HEK616_RS29350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEK616_RS29360	COG1570	exodeoxyribonuclease VII activity
HEK616_RS29365	COG1722	exodeoxyribonuclease VII activity
HEK616_RS29370	COG0778	Nitroreductase
HEK616_RS29395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEK616_RS29395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEK616_RS29400	COG0114	fumarate hydratase activity
HEK616_RS29410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEK616_RS29420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEK616_RS29450	COG0450	alkyl hydroperoxide reductase
HEK616_RS29455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEK616_RS29470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEK616_RS29475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEK616_RS29480	COG0667	Aldo Keto reductase
HEK616_RS29495	COG0640	Transcriptional regulator
HEK616_RS29515	COG2885	chlorophyll binding
HEK616_RS29560	COG2894	cell division
HEK616_RS29595	COG2610	gluconate transmembrane transporter activity
HEK616_RS29600	COG0251	oxidation-reduction process
HEK616_RS29605	COG1414	Transcriptional regulator
HEK616_RS29620	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEK616_RS29640	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HEK616_RS29660	COG0154	amidase activity
HEK616_RS29670	COG1331	Highly conserved protein containing a thioredoxin domain
HEK616_RS29685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEK616_RS29695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEK616_RS29710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEK616_RS29715	COG2255	four-way junction helicase activity
HEK616_RS29740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEK616_RS29770	COG4221	oxidoreductase activity
HEK616_RS29785	COG1733	regulation of RNA biosynthetic process
HEK616_RS29810	COG2986	histidine ammonia-lyase
HEK616_RS29820	COG1024	Enoyl-CoA hydratase
HEK616_RS29825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEK616_RS29835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEK616_RS29850	COG0768	penicillin binding
HEK616_RS29855	COG0424	maF-like protein
HEK616_RS29865	COG0693	protein deglycase activity
HEK616_RS29895	COG4770	biotin carboxylase activity
HEK616_RS29930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEK616_RS29945	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS29970	COG1595	DNA-templated transcription, initiation
HEK616_RS29975	COG0745	RESPONSE REGULATOR receiver
HEK616_RS29980	COG2205	protein histidine kinase activity
HEK616_RS30005	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEK616_RS30015	COG0583	DNA-binding transcription factor activity
HEK616_RS30020	COG2814	Major facilitator Superfamily
HEK616_RS30070	COG1079	Belongs to the binding-protein-dependent transport system permease family
HEK616_RS30075	COG4603	Belongs to the binding-protein-dependent transport system permease family
HEK616_RS30080	COG3845	ABC transporter
HEK616_RS30085	COG1744	ABC transporter substrate-binding protein PnrA-like
HEK616_RS30090	COG1473	amidohydrolase
HEK616_RS30090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEK616_RS30100	COG2089	acid synthase
HEK616_RS30115	COG1216	Glycosyl transferase, family 2
HEK616_RS30125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEK616_RS30145	COG3265	gluconokinase activity
HEK616_RS30150	COG2186	Transcriptional regulator
HEK616_RS30160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEK616_RS30160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEK616_RS30190	COG2009	succinate dehydrogenase
HEK616_RS30200	COG1053	succinate dehydrogenase
HEK616_RS30205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEK616_RS30255	COG1408	metallophosphoesterase
HEK616_RS30270	COG1686	Belongs to the peptidase S11 family
HEK616_RS30275	COG1295	ribonuclease BN
HEK616_RS30285	COG0180	Tryptophanyl-tRNA synthetase
HEK616_RS30290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEK616_RS30295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEK616_RS30300	COG0754	glutathionylspermidine amidase activity
HEK616_RS30315	COG0456	acetyltransferase
HEK616_RS30325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEK616_RS30330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEK616_RS30335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEK616_RS30345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEK616_RS30350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEK616_RS30365	COG2197	response regulator
HEK616_RS30385	COG4176	ABC-type proline glycine betaine transport system permease component
HEK616_RS30395	COG0517	IMP dehydrogenase activity
HEK616_RS30395	COG4175	Glycine betaine
HEK616_RS30405	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS30460	COG0039	L-malate dehydrogenase activity
HEK616_RS30490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEK616_RS30495	COG1714	RDD family
HEK616_RS30505	COG0138	bifunctional purine biosynthesis protein purh
HEK616_RS30535	COG0045	succinate-CoA ligase (ADP-forming) activity
HEK616_RS30550	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEK616_RS30555	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HEK616_RS30560	COG0714	Associated with various cellular activities
HEK616_RS30575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEK616_RS30605	COG0791	NLP P60 protein
HEK616_RS30615	COG2197	response regulator
HEK616_RS30625	COG0515	serine threonine protein kinase
HEK616_RS30625	COG2815	serine threonine protein kinase
HEK616_RS30670	COG2084	Dehydrogenase
HEK616_RS30680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEK616_RS30680	COG0519	Catalyzes the synthesis of GMP from XMP
HEK616_RS30700	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS30705	COG0515	serine threonine protein kinase
HEK616_RS30800	COG2945	thiolester hydrolase activity
HEK616_RS30800	COG0596	Alpha beta hydrolase
HEK616_RS30810	COG4821	SIS domain
HEK616_RS30820	COG0259	pyridoxamine-phosphate oxidase activity
HEK616_RS30850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEK616_RS30870	COG0583	DNA-binding transcription factor activity
HEK616_RS30895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEK616_RS30905	COG2252	PERMEase
HEK616_RS30935	COG0667	Aldo Keto reductase
HEK616_RS30950	COG2801	Transposase and inactivated derivatives
HEK616_RS30950	COG3415	Transposase
HEK616_RS30960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEK616_RS30965	COG2378	regulation of single-species biofilm formation
HEK616_RS30975	COG0247	lactate metabolic process
HEK616_RS30975	COG0277	FAD linked oxidase domain protein
HEK616_RS30995	COG2814	Major facilitator Superfamily
HEK616_RS31005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEK616_RS31010	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEK616_RS31030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEK616_RS31035	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEK616_RS31040	COG1120	ATPase activity
HEK616_RS31045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEK616_RS31060	COG1061	Type III restriction enzyme res subunit
HEK616_RS31075	COG3973	AAA domain
HEK616_RS31085	COG2814	Major facilitator Superfamily
HEK616_RS31115	COG1737	Transcriptional regulator
HEK616_RS31120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEK616_RS31125	COG1263	PTS System
HEK616_RS31125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEK616_RS31145	COG1278	Cold shock
HEK616_RS31160	COG0463	Glycosyl transferase, family 2
HEK616_RS31175	COG3415	Transposase
HEK616_RS31175	COG2801	Transposase and inactivated derivatives
HEK616_RS31180	COG3415	Transposase
HEK616_RS31180	COG2801	Transposase and inactivated derivatives
HEK616_RS31230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEK616_RS31255	COG4585	Histidine kinase
HEK616_RS31260	COG2197	response regulator
HEK616_RS31285	COG2815	serine threonine protein kinase
HEK616_RS31285	COG0515	serine threonine protein kinase
HEK616_RS31290	COG2391	methyltransferase activity
HEK616_RS31300	COG1686	Belongs to the peptidase S11 family
HEK616_RS31310	COG0582	viral genome integration into host DNA
HEK616_RS31320	COG3842	ATPase activity
HEK616_RS31330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEK616_RS31350	COG0215	cysteine-tRNA ligase activity
HEK616_RS31360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEK616_RS31365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEK616_RS31370	COG1329	Transcriptional regulator
HEK616_RS31385	COG5002	protein histidine kinase activity
HEK616_RS31415	COG0588	phosphoglycerate mutase activity
HEK616_RS31430	COG4106	trans-aconitate 2-methyltransferase activity
HEK616_RS31440	COG0438	transferase activity, transferring glycosyl groups
HEK616_RS31455	COG0667	Aldo Keto reductase
HEK616_RS31485	COG0456	acetyltransferase
HEK616_RS31490	COG0737	Belongs to the 5'-nucleotidase family
HEK616_RS31495	COG0702	epimerase
HEK616_RS31505	COG2972	Histidine kinase
HEK616_RS31505	COG2205	protein histidine kinase activity
HEK616_RS31510	COG0745	RESPONSE REGULATOR receiver
HEK616_RS31520	COG1609	Transcriptional regulator
HEK616_RS31525	COG0745	RESPONSE REGULATOR receiver
HEK616_RS31565	COG2897	thiosulfate sulfurtransferase activity
HEK616_RS31585	COG3485	protocatechuate 3,4-dioxygenase
HEK616_RS31590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEK616_RS31595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HEK616_RS31605	COG0735	belongs to the Fur family
HEK616_RS31615	COG1490	D-aminoacyl-tRNA deacylase activity
HEK616_RS31635	COG0431	NADPH-dependent FMN reductase
HEK616_RS31650	COG1733	regulation of RNA biosynthetic process
HEK616_RS31675	COG0667	Aldo Keto reductase
HEK616_RS31690	COG2890	protein-(glutamine-N5) methyltransferase activity
HEK616_RS31700	COG1733	regulation of RNA biosynthetic process
HEK616_RS31715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEK616_RS31745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEK616_RS31760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEK616_RS31765	COG0306	phosphate transporter
HEK616_RS31775	COG1937	Protein conserved in bacteria
HEK616_RS31795	COG0277	FAD linked oxidase domain protein
HEK616_RS31800	COG0671	phosphoesterase, PA-phosphatase related
HEK616_RS31805	COG0739	heme binding
HEK616_RS31805	COG0741	lytic transglycosylase activity
HEK616_RS31805	COG1196	nuclear chromosome segregation
HEK616_RS31855	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS31865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS31870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS31880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS31885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEK616_RS31910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEK616_RS31930	COG0180	Tryptophanyl-tRNA synthetase
HEK616_RS31935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEK616_RS31950	COG1252	NADH dehydrogenase
HEK616_RS31955	COG1595	DNA-templated transcription, initiation
HEK616_RS31965	COG1309	transcriptional regulator
HEK616_RS31985	COG4991	sh3 domain protein
HEK616_RS32030	COG0129	dihydroxy-acid dehydratase activity
HEK616_RS32035	COG1082	Xylose isomerase domain protein TIM barrel
HEK616_RS32040	COG0248	Ppx GppA phosphatase
HEK616_RS32060	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HEK616_RS32085	COG1194	a g-specific adenine glycosylase
HEK616_RS32090	COG1595	DNA-templated transcription, initiation
HEK616_RS32100	COG0745	RESPONSE REGULATOR receiver
HEK616_RS32105	COG2205	protein histidine kinase activity
HEK616_RS32120	COG0739	heme binding
HEK616_RS32150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEK616_RS32170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEK616_RS32180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEK616_RS32185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEK616_RS32205	COG2197	response regulator
HEK616_RS32220	COG0649	NAD binding
HEK616_RS32235	COG1174	glycine betaine transport
HEK616_RS32240	COG1174	glycine betaine transport
HEK616_RS32250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEK616_RS32255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEK616_RS32280	COG0302	gtp cyclohydrolase
HEK616_RS32295	COG0037	tRNA processing
HEK616_RS32305	COG2027	D-alanyl-D-alanine carboxypeptidase
HEK616_RS32310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEK616_RS32315	COG1132	(ABC) transporter
HEK616_RS32365	COG0393	Putative heavy-metal-binding
HEK616_RS32370	COG0789	Transcriptional regulator
HEK616_RS32395	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEK616_RS32400	COG0076	glutamate decarboxylase activity
HEK616_RS32410	COG1012	belongs to the aldehyde dehydrogenase family
HEK616_RS32435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEK616_RS32445	COG0254	rRNA binding
HEK616_RS32450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEK616_RS32465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEK616_RS32465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEK616_RS32520	COG1309	transcriptional regulator
HEK616_RS32540	COG3594	Acyltransferase
HEK616_RS32545	COG0584	glycerophosphoryl diester phosphodiesterase
HEK616_RS32550	COG0456	acetyltransferase
HEK616_RS32560	COG1175	transmembrane transport
HEK616_RS32585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HEK616_RS32700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEK616_RS32705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEK616_RS32710	COG1754	DNA topoisomerase type I activity
HEK616_RS32710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEK616_RS32735	COG2890	protein-(glutamine-N5) methyltransferase activity
HEK616_RS32745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEK616_RS32750	COG2172	sigma factor antagonist activity
HEK616_RS32755	COG1366	Belongs to the anti-sigma-factor antagonist family
HEK616_RS32760	COG1205	dead DEAH box helicase
HEK616_RS32760	COG1111	helicase
HEK616_RS32820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEK616_RS32825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEK616_RS32835	COG0596	Alpha beta hydrolase
HEK616_RS32870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEK616_RS32895	COG0003	Pfam Anion-transporting ATPase
HEK616_RS32910	COG1610	YqeY-like protein
HEK616_RS32915	COG1408	metallophosphoesterase
HEK616_RS32940	COG4249	Peptidase C14 caspase catalytic subunit p20
HEK616_RS32940	COG2319	Wd-40 repeat
HEK616_RS32945	COG2188	Transcriptional regulator
HEK616_RS32970	COG1309	transcriptional regulator
HEK616_RS32975	COG2124	cytochrome p450
HEK616_RS33010	COG1595	DNA-templated transcription, initiation
HEK616_RS33030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEK616_RS33035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEK616_RS33060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEK616_RS33090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEK616_RS33095	COG1132	(ABC) transporter
HEK616_RS33105	COG0477	Major facilitator Superfamily
HEK616_RS33120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEK616_RS33140	COG0189	ligase activity
HEK616_RS33150	COG0402	S-adenosylhomocysteine deaminase activity
HEK616_RS33155	COG0477	Major facilitator Superfamily
HEK616_RS33170	COG1834	amidinotransferase
HEK616_RS33175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEK616_RS33215	COG2268	Band 7 protein
HEK616_RS33240	COG1064	alcohol dehydrogenase
HEK616_RS33275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEK616_RS33320	COG1191	sigma factor activity
HEK616_RS33325	COG1191	sigma factor activity
HEK616_RS33345	COG0789	Transcriptional regulator
HEK616_RS33370	COG0477	Major facilitator Superfamily
HEK616_RS33375	COG2353	YceI-like domain
HEK616_RS33385	COG0477	Major facilitator Superfamily
HEK616_RS33390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEK616_RS33400	COG2205	protein histidine kinase activity
HEK616_RS33405	COG0745	RESPONSE REGULATOR receiver
HEK616_RS33410	COG0431	NADPH-dependent FMN reductase
HEK616_RS33410	COG1053	succinate dehydrogenase
HEK616_RS33410	COG3976	FMN-binding domain protein
HEK616_RS33430	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEK616_RS33455	COG2188	Transcriptional regulator
HEK616_RS33525	COG5000	phosphorelay sensor kinase activity
HEK616_RS33535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEK616_RS33540	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS33555	COG3437	response regulator, receiver
HEK616_RS33555	COG3850	Histidine kinase
HEK616_RS33555	COG4999	Histidine kinase
HEK616_RS33555	COG2205	protein histidine kinase activity
HEK616_RS33565	COG1595	DNA-templated transcription, initiation
HEK616_RS33580	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS33590	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS33625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEK616_RS33665	COG0006	proline dipeptidase activity
HEK616_RS33700	COG2372	response to copper ion
HEK616_RS33705	COG2837	iron assimilation
HEK616_RS33715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEK616_RS33720	COG0561	phosphatase activity
HEK616_RS33745	COG0583	DNA-binding transcription factor activity
HEK616_RS33765	COG2186	Transcriptional regulator
HEK616_RS33770	COG2807	transmembrane transport
HEK616_RS33775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEK616_RS33795	COG1131	(ABC) transporter
HEK616_RS33815	COG0789	Transcriptional regulator
HEK616_RS33820	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HEK616_RS33835	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEK616_RS33845	COG0501	Belongs to the peptidase M48B family
HEK616_RS33855	COG0561	phosphatase activity
HEK616_RS33865	COG4988	ABC transporter
HEK616_RS33870	COG1294	oxidase, subunit
HEK616_RS33875	COG1271	oxidase subunit
HEK616_RS33885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEK616_RS33890	COG1609	Transcriptional regulator
HEK616_RS33895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEK616_RS33905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HEK616_RS33930	COG0662	Cupin 2, conserved barrel domain protein
HEK616_RS33935	COG1950	PFAM Membrane protein of
HEK616_RS33940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEK616_RS33985	COG2814	Major facilitator Superfamily
HEK616_RS34020	COG4978	Transcriptional regulator
HEK616_RS34020	COG0789	Transcriptional regulator
HEK616_RS34030	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEK616_RS34035	COG0305	Participates in initiation and elongation during chromosome replication
HEK616_RS34040	COG0534	Mate efflux family protein
HEK616_RS34050	COG0359	binds to the 23S rRNA
HEK616_RS34055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEK616_RS34060	COG0629	single-stranded DNA binding
HEK616_RS34065	COG0360	Binds together with S18 to 16S ribosomal RNA
HEK616_RS34090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEK616_RS34095	COG1695	Transcriptional regulator
HEK616_RS34130	COG0515	serine threonine protein kinase
HEK616_RS34130	COG2815	serine threonine protein kinase
HEK616_RS34135	COG1595	DNA-templated transcription, initiation
HEK616_RS34145	COG0492	ferredoxin-NADP+ reductase activity
HEK616_RS34150	COG3118	belongs to the thioredoxin family
HEK616_RS34165	COG1192	Involved in chromosome partitioning
HEK616_RS34170	COG0357	Ribosomal RNA small subunit methyltransferase G
HEK616_RS34175	COG1847	R3H domain protein
HEK616_RS34180	COG0706	membrane insertase activity
HEK616_RS34185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HEK616_RS34190	COG0594	ribonuclease P activity
HEK616_RS34195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEK616_RS34205	COG0592	DNA-directed DNA polymerase activity
HEK616_RS34210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEK616_RS34215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEK616_RS34220	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HEK616_RS34225	COG0187	DNA topoisomerase II activity
HEK616_RS34230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEK616_RS34260	COG0515	serine threonine protein kinase
HEK616_RS34285	COG0705	Rhomboid family
HEK616_RS34300	COG3764	Sortase (surface protein transpeptidase)
HEK616_RS34315	COG3764	Sortase (surface protein transpeptidase)
HEK616_RS34320	COG3764	Sortase (surface protein transpeptidase)
HEK616_RS34325	COG0515	serine threonine protein kinase
HEK616_RS34330	COG0768	penicillin binding
HEK616_RS34345	COG1716	ATPase activity
HEK616_RS34350	COG1716	ATPase activity
HEK616_RS34360	COG0583	DNA-binding transcription factor activity
HEK616_RS34365	COG2814	Major facilitator Superfamily
HEK616_RS34370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HEK616_RS34375	COG1733	regulation of RNA biosynthetic process
HEK616_RS34410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEK616_RS34415	COG2151	metal-sulfur cluster biosynthetic enzyme
HEK616_RS34420	COG3396	Phenylacetate-CoA oxygenase
HEK616_RS34425	COG3460	Phenylacetate-CoA oxygenase
HEK616_RS34430	COG3396	Phenylacetate-CoA oxygenase
HEK616_RS34455	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEK616_RS34460	COG1309	transcriptional regulator
HEK616_RS34465	COG1522	sequence-specific DNA binding
HEK616_RS34480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEK616_RS34485	COG0746	molybdenum cofactor guanylyltransferase activity
HEK616_RS34490	COG0303	'Molybdopterin
HEK616_RS34495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEK616_RS34515	COG0515	serine threonine protein kinase
HEK616_RS34520	COG0515	serine threonine protein kinase
HEK616_RS34545	COG0022	dehydrogenase e1 component
HEK616_RS34550	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEK616_RS34620	COG3629	intracellular signal transduction
HEK616_RS34620	COG3903	Transcriptional regulator
HEK616_RS34625	COG1362	aminopeptidase activity
HEK616_RS34630	COG1960	acyl-CoA dehydrogenase activity
HEK616_RS34655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEK616_RS34665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEK616_RS34685	COG1174	glycine betaine transport
HEK616_RS34690	COG1174	glycine betaine transport
HEK616_RS34695	COG1732	Glycine betaine
HEK616_RS34705	COG0745	RESPONSE REGULATOR receiver
HEK616_RS34750	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HEK616_RS34815	COG1316	TRANSCRIPTIONal
HEK616_RS34825	COG0501	Belongs to the peptidase M48B family
HEK616_RS34850	COG0318	PFAM AMP-dependent synthetase and ligase
HEK616_RS34855	COG2030	dehydratase
HEK616_RS34865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEK616_RS34885	COG0028	Belongs to the TPP enzyme family
HEK616_RS34910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS34920	COG0515	serine threonine protein kinase
HEK616_RS34940	COG2197	response regulator
HEK616_RS34955	COG1652	LysM domain
HEK616_RS34985	COG0515	serine threonine protein kinase
HEK616_RS35005	COG0583	DNA-binding transcription factor activity
HEK616_RS35010	COG0477	Major facilitator Superfamily
HEK616_RS35015	COG3979	chitinase
HEK616_RS35115	COG3708	Transcriptional regulator
HEK616_RS35115	COG2207	Transcriptional regulator
HEK616_RS35150	COG0717	Belongs to the dCTP deaminase family
HEK616_RS35155	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HEK616_RS35170	COG0247	lactate metabolic process
HEK616_RS35170	COG2181	nitrate reductase activity
HEK616_RS35175	COG0443	Heat shock 70 kDa protein
HEK616_RS35180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEK616_RS35185	COG0484	heat shock protein binding
HEK616_RS35190	COG0789	Transcriptional regulator
HEK616_RS35205	COG0542	response to heat
HEK616_RS35230	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HEK616_RS35245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEK616_RS35250	COG0191	fructose-bisphosphate aldolase activity
HEK616_RS35270	COG3844	kynureninase activity
HEK616_RS35280	COG4585	Histidine kinase
HEK616_RS35285	COG2197	response regulator
HEK616_RS35290	COG3559	Exporter of polyketide antibiotics
HEK616_RS35295	COG1131	(ABC) transporter
HEK616_RS35310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEK616_RS35325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEK616_RS35330	COG1802	Transcriptional regulator
HEK616_RS35345	COG0151	Belongs to the GarS family
HEK616_RS35370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HEK616_RS35395	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEK616_RS35400	COG0047	phosphoribosylformylglycinamidine synthase activity
HEK616_RS35405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEK616_RS35415	COG3119	arylsulfatase activity
HEK616_RS35425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HEK616_RS35460	COG1643	Atp-dependent helicase
HEK616_RS35500	COG0513	Belongs to the DEAD box helicase family
HEK616_RS35535	COG0667	Aldo Keto reductase
HEK616_RS35555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HEK616_RS35560	COG0579	oxidoreductase
HEK616_RS35585	COG1252	NADH dehydrogenase
HEK616_RS35600	COG1846	Transcriptional regulator
HEK616_RS35620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEK616_RS35625	COG2223	nitrite transmembrane transporter activity
HEK616_RS35630	COG0123	including yeast histone deacetylase and acetoin utilization protein
HEK616_RS35680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HEK616_RS35685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEK616_RS35690	COG0181	hydroxymethylbilane synthase activity
HEK616_RS35695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEK616_RS35695	COG1648	precorrin-2 dehydrogenase activity
HEK616_RS35700	COG0113	porphobilinogen synthase activity
HEK616_RS35705	COG3237	CsbD-like
HEK616_RS35710	COG0018	arginyl-trna synthetase
HEK616_RS35715	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HEK616_RS35740	COG1690	Belongs to the RtcB family
HEK616_RS35760	COG1742	UPF0060 membrane protein
HEK616_RS35765	COG4181	ATPase activity
HEK616_RS35770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS35800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEK616_RS35805	COG0406	alpha-ribazole phosphatase activity
HEK616_RS35815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEK616_RS35820	COG0785	Cytochrome C biogenesis protein
HEK616_RS35825	COG1333	cytochrome c biogenesis protein
HEK616_RS35830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEK616_RS35850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEK616_RS35855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEK616_RS35865	COG0163	prenyltransferase activity
HEK616_RS35880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEK616_RS35890	COG1301	dicarboxylic acid transport
HEK616_RS35915	COG1309	transcriptional regulator
HEK616_RS35960	COG1278	Cold shock
HEK616_RS35965	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEK616_RS35975	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEK616_RS35985	COG2226	methyltransferase
HEK616_RS36030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEK616_RS36035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEK616_RS36040	COG0649	NAD binding
HEK616_RS36050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEK616_RS36055	COG1034	ATP synthesis coupled electron transport
HEK616_RS36060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEK616_RS36065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEK616_RS36070	COG0839	Belongs to the complex I subunit 6 family
HEK616_RS36075	COG0713	ATP synthesis coupled electron transport
HEK616_RS36080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEK616_RS36090	COG1007	ATP synthesis coupled electron transport
HEK616_RS36120	COG0142	geranyltranstransferase activity
HEK616_RS36145	COG0702	epimerase
HEK616_RS36150	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEK616_RS36155	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEK616_RS36155	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEK616_RS36165	COG4585	Histidine kinase
HEK616_RS36170	COG4585	Histidine kinase
HEK616_RS36185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEK616_RS36195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEK616_RS36200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEK616_RS36205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEK616_RS36210	COG0839	Belongs to the complex I subunit 6 family
HEK616_RS36215	COG0713	ATP synthesis coupled electron transport
HEK616_RS36230	COG1007	ATP synthesis coupled electron transport
HEK616_RS36235	COG0501	Belongs to the peptidase M48B family
HEK616_RS36240	COG3304	Inner membrane component domain
HEK616_RS36250	COG1666	GTP binding
HEK616_RS36265	COG0402	S-adenosylhomocysteine deaminase activity
HEK616_RS36280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEK616_RS36285	COG2030	dehydratase
HEK616_RS36295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEK616_RS36300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEK616_RS36305	COG0436	Aminotransferase
HEK616_RS36320	COG0250	Participates in transcription elongation, termination and antitermination
HEK616_RS36325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEK616_RS36330	COG0081	regulation of translation
HEK616_RS36340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEK616_RS36345	COG0222	ribosome binding
HEK616_RS36350	COG0085	RNA polymerase activity
HEK616_RS36355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEK616_RS36365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEK616_RS36370	COG0049	tRNA binding
HEK616_RS36375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEK616_RS36380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEK616_RS36385	COG0051	transcription antitermination factor activity, RNA binding
HEK616_RS36390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEK616_RS36395	COG0088	Forms part of the polypeptide exit tunnel
HEK616_RS36400	COG0089	rRNA binding
HEK616_RS36405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEK616_RS36410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEK616_RS36415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEK616_RS36420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEK616_RS36425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEK616_RS36430	COG0255	Belongs to the universal ribosomal protein uL29 family
HEK616_RS36435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEK616_RS36440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEK616_RS36445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEK616_RS36450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEK616_RS36455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEK616_RS36460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEK616_RS36465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEK616_RS36470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEK616_RS36475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEK616_RS36480	COG1841	ribosomal large subunit assembly
HEK616_RS36485	COG0200	Binds to the 23S rRNA
HEK616_RS36495	COG0563	adenylate kinase activity
HEK616_RS36505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEK616_RS36510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEK616_RS36515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEK616_RS36520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEK616_RS36525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEK616_RS36530	COG0202	RNA polymerase activity
HEK616_RS36535	COG0203	ribosomal protein L17
HEK616_RS36540	COG0101	tRNA pseudouridine synthase activity
HEK616_RS36550	COG0488	(ABC) transporter
HEK616_RS36555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEK616_RS36560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HEK616_RS36565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEK616_RS36575	COG1072	(Pantothenic acid kinase))
HEK616_RS36585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEK616_RS36590	COG0736	holo-[acyl-carrier-protein] synthase activity
HEK616_RS36615	COG0802	atpase or kinase
HEK616_RS36640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEK616_RS36655	COG0772	Belongs to the SEDS family
HEK616_RS36660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEK616_RS36670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEK616_RS36690	COG4221	oxidoreductase activity
HEK616_RS36700	COG0583	DNA-binding transcription factor activity
HEK616_RS36715	COG1595	DNA-templated transcription, initiation
HEK616_RS36725	COG0516	GMP reductase activity
HEK616_RS36740	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS36750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS36765	COG4585	Histidine kinase
HEK616_RS36770	COG2197	response regulator
HEK616_RS36780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEK616_RS36810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEK616_RS36830	COG1309	transcriptional regulator
HEK616_RS36835	COG0596	Alpha beta hydrolase
HEK616_RS36865	COG2207	Transcriptional regulator
HEK616_RS36870	COG2223	nitrite transmembrane transporter activity
HEK616_RS36895	COG2226	methyltransferase
HEK616_RS36900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEK616_RS36905	COG1993	acr, cog1993
HEK616_RS36910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEK616_RS36935	COG1032	radical SAM domain protein
HEK616_RS36950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS36955	COG3291	Pkd domain containing protein
HEK616_RS36970	COG2124	cytochrome p450
HEK616_RS37050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEK616_RS37055	COG2423	ornithine cyclodeaminase activity
HEK616_RS37070	COG3135	benzoate transporter
HEK616_RS37090	COG0596	Alpha beta hydrolase
HEK616_RS37095	COG3896	Chloramphenicol phosphotransferase-like protein
HEK616_RS37185	COG1733	regulation of RNA biosynthetic process
HEK616_RS37190	COG4214	carbohydrate transport
HEK616_RS37220	COG1414	Transcriptional regulator
HEK616_RS37225	COG3386	PFAM SMP-30 Gluconolaconase
HEK616_RS37255	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS37280	COG0583	DNA-binding transcription factor activity
HEK616_RS37315	COG4221	oxidoreductase activity
HEK616_RS37335	COG0701	Predicted permease
HEK616_RS37340	COG2135	peptidase activity
HEK616_RS37345	COG0789	Transcriptional regulator
HEK616_RS37350	COG1819	glycosyl
HEK616_RS37370	COG1132	(ABC) transporter
HEK616_RS37430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEK616_RS37445	COG1595	DNA-templated transcription, initiation
HEK616_RS37450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEK616_RS37490	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS37495	COG1846	Transcriptional regulator
HEK616_RS37545	COG1595	DNA-templated transcription, initiation
HEK616_RS37555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEK616_RS37560	COG0583	DNA-binding transcription factor activity
HEK616_RS37565	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS37570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEK616_RS37575	COG1720	tRNA m6t6A37 methyltransferase activity
HEK616_RS37650	COG1063	alcohol dehydrogenase
HEK616_RS37665	COG2267	carboxylic ester hydrolase activity
HEK616_RS37690	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEK616_RS37760	COG1522	sequence-specific DNA binding
HEK616_RS37770	COG2197	response regulator
HEK616_RS37790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEK616_RS37840	COG1595	DNA-templated transcription, initiation
HEK616_RS37855	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HEK616_RS37875	COG0137	argininosuccinate synthase activity
HEK616_RS37885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEK616_RS37895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEK616_RS37915	COG2814	Major facilitator Superfamily
HEK616_RS37945	COG0515	serine threonine protein kinase
HEK616_RS37945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEK616_RS37955	COG0702	epimerase
HEK616_RS38005	COG0501	Belongs to the peptidase M48B family
HEK616_RS38010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEK616_RS38015	COG1595	DNA-templated transcription, initiation
HEK616_RS38020	COG0412	Dienelactone hydrolase
HEK616_RS38025	COG1522	sequence-specific DNA binding
HEK616_RS38040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEK616_RS38060	COG0483	inositol monophosphate 1-phosphatase activity
HEK616_RS38105	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEK616_RS38120	COG3973	AAA domain
HEK616_RS38210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEK616_RS38215	COG0604	alcohol dehydrogenase
HEK616_RS38215	COG3321	synthase
HEK616_RS38215	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS38235	COG3848	Pyruvate phosphate dikinase
HEK616_RS38235	COG0574	Belongs to the PEP-utilizing enzyme family
HEK616_RS38240	COG3903	Transcriptional regulator
HEK616_RS38240	COG3629	intracellular signal transduction
HEK616_RS38260	COG0069	glutamate synthase activity
HEK616_RS38265	COG1191	sigma factor activity
HEK616_RS38275	COG1309	transcriptional regulator
HEK616_RS38315	COG0596	Alpha beta hydrolase
HEK616_RS38340	COG1366	Belongs to the anti-sigma-factor antagonist family
HEK616_RS38405	COG4585	Histidine kinase
HEK616_RS38425	COG2318	DinB family
HEK616_RS38440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEK616_RS38510	COG2326	polyphosphate kinase activity
HEK616_RS38515	COG0517	IMP dehydrogenase activity
HEK616_RS38515	COG0516	GMP reductase activity
HEK616_RS38520	COG2239	Acts as a magnesium transporter
HEK616_RS38570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEK616_RS38575	COG0604	alcohol dehydrogenase
HEK616_RS38575	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS38575	COG3321	synthase
HEK616_RS38580	COG1959	2 iron, 2 sulfur cluster binding
HEK616_RS38625	COG2318	DinB family
HEK616_RS38630	COG1132	(ABC) transporter
HEK616_RS38650	COG1309	transcriptional regulator
HEK616_RS38670	COG0590	tRNA wobble adenosine to inosine editing
HEK616_RS38675	COG3224	Antibiotic biosynthesis monooxygenase
HEK616_RS38680	COG0277	FAD linked oxidase domain protein
HEK616_RS38715	COG2205	protein histidine kinase activity
HEK616_RS38775	COG1028	Short-chain dehydrogenase reductase Sdr
HEK616_RS38785	COG2226	methyltransferase
HEK616_RS38790	COG1021	2,3-dihydroxybenzoate-AMP ligase
HEK616_RS38800	COG2304	oxidoreductase activity
HEK616_RS38830	COG1280	lysine exporter protein (LysE YggA)
HEK616_RS38835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEK616_RS38875	COG2815	serine threonine protein kinase
HEK616_RS38875	COG0515	serine threonine protein kinase
HEK616_RS38880	COG2197	response regulator
HEK616_RS38885	COG1674	ftsk spoiiie
HEK616_RS38900	COG0464	growth
HEK616_RS38955	COG3903	Transcriptional regulator
HEK616_RS38955	COG3629	intracellular signal transduction
HEK616_RS38965	COG3903	Transcriptional regulator
HEK616_RS38965	COG2197	response regulator
HEK616_RS38975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEK616_RS38980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEK616_RS39005	COG0842	Transport permease protein
HEK616_RS39005	COG1129	ABC transporter
HEK616_RS39020	COG0583	DNA-binding transcription factor activity
HEK616_RS39040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEK616_RS39045	COG3226	Transcriptional regulator
HEK616_RS39065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEK616_RS39090	COG4977	sequence-specific DNA binding
HEK616_RS39095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEK616_RS39110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEK616_RS39115	COG4585	Histidine kinase
HEK616_RS39120	COG2197	response regulator
HEK616_RS39130	COG2272	Belongs to the type-B carboxylesterase lipase family
HEK616_RS39225	COG2124	cytochrome p450
HEK616_RS39255	COG3631	Ketosteroid isomerase-related protein
HEK616_RS39260	COG0702	epimerase
HEK616_RS39270	COG2132	Multicopper oxidase
HEK616_RS39305	COG0454	-acetyltransferase
HEK616_RS39310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEK616_RS39350	COG1335	isochorismatase
HEK616_RS39360	COG0583	DNA-binding transcription factor activity
HEK616_RS39375	COG0477	Major facilitator Superfamily
HEK616_RS39390	COG0745	RESPONSE REGULATOR receiver
HEK616_RS39395	COG2205	protein histidine kinase activity
HEK616_RS39410	COG1733	regulation of RNA biosynthetic process
HEK616_RS39445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEK616_RS39445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEK616_RS39455	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HEK616_RS39565	COG0667	Aldo Keto reductase
HEK616_RS39605	COG4585	Histidine kinase
HEK616_RS39610	COG2197	response regulator
HEK616_RS39650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS39700	COG4552	Acetyltransferase involved in intracellular survival and related
HEK616_RS39715	COG1309	transcriptional regulator
HEK616_RS39735	COG0010	Belongs to the arginase family
HEK616_RS39740	COG0583	DNA-binding transcription factor activity
HEK616_RS39755	COG0590	tRNA wobble adenosine to inosine editing
HEK616_RS39765	COG0583	DNA-binding transcription factor activity
HEK616_RS39785	COG0477	Major facilitator Superfamily
HEK616_RS39795	COG0306	phosphate transporter
HEK616_RS39825	COG3629	intracellular signal transduction
HEK616_RS39825	COG3903	Transcriptional regulator
HEK616_RS39870	COG0477	Major facilitator Superfamily
HEK616_RS39890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEK616_RS39920	COG0142	geranyltranstransferase activity
HEK616_RS39945	COG1846	Transcriptional regulator
HEK616_RS39950	COG1902	pentaerythritol trinitrate reductase activity
HEK616_RS39975	COG1309	transcriptional regulator
HEK616_RS39985	COG1522	sequence-specific DNA binding
HEK616_RS39995	COG1687	branched-chain amino acid
HEK616_RS40100	COG0513	Belongs to the DEAD box helicase family
HEK616_RS40110	COG0640	Transcriptional regulator
HEK616_RS40120	COG0765	amino acid transport
HEK616_RS40130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEK616_RS40160	COG0515	serine threonine protein kinase
HEK616_RS40205	COG0148	phosphopyruvate hydratase activity
HEK616_RS40300	COG1335	isochorismatase
HEK616_RS40340	COG1846	Transcriptional regulator
HEK616_RS40485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEK616_RS40615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEK616_RS40635	COG1733	regulation of RNA biosynthetic process
HEK616_RS40655	COG0656	L-ascorbic acid biosynthetic process
HEK616_RS40665	COG0667	Aldo Keto reductase
HEK616_RS40735	COG1131	(ABC) transporter
HEK616_RS41170	COG2801	Transposase and inactivated derivatives
HEK616_RS41170	COG3415	Transposase
HEK616_RS41230	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEK616_RS41240	COG1132	(ABC) transporter
HEK616_RS41285	COG3547	Transposase (IS116 IS110 IS902 family)
HEK616_RS41385	COG4249	Peptidase C14 caspase catalytic subunit p20
HEK616_RS41385	COG2319	Wd-40 repeat