locus-tag	class	description
BBN63_RS00190	COG0647	UMP catabolic process
BBN63_RS00215	COG0436	Aminotransferase
BBN63_RS00230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBN63_RS00260	COG0604	alcohol dehydrogenase
BBN63_RS00260	COG3321	synthase
BBN63_RS00270	COG0235	Class ii aldolase
BBN63_RS00270	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BBN63_RS00275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BBN63_RS00275	COG0235	Class ii aldolase
BBN63_RS00280	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BBN63_RS00285	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BBN63_RS00290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BBN63_RS00300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BBN63_RS00360	COG0640	Transcriptional regulator
BBN63_RS00370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBN63_RS00375	COG3293	Transposase
BBN63_RS00415	COG2814	Major facilitator Superfamily
BBN63_RS00420	COG0640	Transcriptional regulator
BBN63_RS00435	COG3547	Transposase (IS116 IS110 IS902 family)
BBN63_RS00450	COG0142	geranyltranstransferase activity
BBN63_RS00560	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS00600	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS00615	COG0667	Aldo Keto reductase
BBN63_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS00630	COG1309	transcriptional regulator
BBN63_RS00715	COG0513	Belongs to the DEAD box helicase family
BBN63_RS00720	COG1278	Cold shock
BBN63_RS00745	COG0477	Major facilitator Superfamily
BBN63_RS00765	COG0395	ABC-type sugar transport system, permease component
BBN63_RS00780	COG1609	Transcriptional regulator
BBN63_RS00790	COG1309	transcriptional regulator
BBN63_RS00805	COG3693	PFAM glycoside hydrolase, family 10
BBN63_RS00815	COG1175	transmembrane transport
BBN63_RS00820	COG0395	ABC-type sugar transport system, permease component
BBN63_RS00825	COG3250	beta-galactosidase activity
BBN63_RS00835	COG3250	beta-galactosidase activity
BBN63_RS00840	COG0501	Belongs to the peptidase M48B family
BBN63_RS00845	COG0300	oxidoreductase activity
BBN63_RS00850	COG1309	transcriptional regulator
BBN63_RS00860	COG3647	Membrane
BBN63_RS00930	COG0604	alcohol dehydrogenase
BBN63_RS00930	COG3321	synthase
BBN63_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS00955	COG0789	Transcriptional regulator
BBN63_RS00960	COG1742	UPF0060 membrane protein
BBN63_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS00995	COG2124	cytochrome p450
BBN63_RS01000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BBN63_RS01015	COG0512	Glutamine amidotransferase of anthranilate synthase
BBN63_RS01015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBN63_RS01025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BBN63_RS01040	COG2124	cytochrome p450
BBN63_RS01055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBN63_RS01070	COG2814	Major facilitator Superfamily
BBN63_RS01080	COG2318	DinB family
BBN63_RS01120	COG0673	inositol 2-dehydrogenase activity
BBN63_RS01130	COG4948	Mandelate Racemase Muconate Lactonizing
BBN63_RS01135	COG0395	ABC-type sugar transport system, permease component
BBN63_RS01140	COG1175	transmembrane transport
BBN63_RS01170	COG3226	Transcriptional regulator
BBN63_RS01175	COG0738	Major facilitator superfamily
BBN63_RS01210	COG3903	Transcriptional regulator
BBN63_RS01210	COG3629	intracellular signal transduction
BBN63_RS01230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBN63_RS01235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBN63_RS01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBN63_RS01255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBN63_RS01265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBN63_RS01280	COG4865	methylaspartate mutase activity
BBN63_RS01285	COG0017	Asparaginyl-tRNA synthetase
BBN63_RS01295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBN63_RS01310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBN63_RS01340	COG2271	Major facilitator Superfamily
BBN63_RS01370	COG2226	methyltransferase
BBN63_RS01375	COG1132	(ABC) transporter
BBN63_RS01395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBN63_RS01405	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBN63_RS01425	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS01455	COG1595	DNA-templated transcription, initiation
BBN63_RS01460	COG4221	oxidoreductase activity
BBN63_RS01505	COG1316	TRANSCRIPTIONal
BBN63_RS01535	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BBN63_RS01550	COG1891	lyase activity
BBN63_RS01615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BBN63_RS01625	COG4948	Mandelate Racemase Muconate Lactonizing
BBN63_RS01635	COG1175	transmembrane transport
BBN63_RS01645	COG2188	Transcriptional regulator
BBN63_RS01675	COG1929	Belongs to the glycerate kinase type-1 family
BBN63_RS01685	COG0745	RESPONSE REGULATOR receiver
BBN63_RS01690	COG2205	protein histidine kinase activity
BBN63_RS01705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBN63_RS01710	COG0667	Aldo Keto reductase
BBN63_RS01735	COG0477	Major facilitator Superfamily
BBN63_RS01760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBN63_RS01780	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS01785	COG0747	negative chemotaxis
BBN63_RS01795	COG0601	transmembrane transport
BBN63_RS01800	COG5285	phytanoyl-CoA dioxygenase
BBN63_RS01810	COG0572	uridine kinase
BBN63_RS01825	COG0259	pyridoxamine-phosphate oxidase activity
BBN63_RS01830	COG2226	methyltransferase
BBN63_RS01835	COG0531	amino acid
BBN63_RS01875	COG2226	methyltransferase
BBN63_RS01880	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BBN63_RS01965	COG0583	DNA-binding transcription factor activity
BBN63_RS01980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBN63_RS01980	COG2169	Transcriptional regulator
BBN63_RS02005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBN63_RS02015	COG1819	glycosyl
BBN63_RS02020	COG1132	(ABC) transporter
BBN63_RS02025	COG2755	lipolytic protein G-D-S-L family
BBN63_RS02045	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS02050	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS02055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS02060	COG0601	transmembrane transport
BBN63_RS02070	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS02075	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS02100	COG2362	D-Aminopeptidase
BBN63_RS02110	COG1125	glycine betaine transport
BBN63_RS02110	COG0517	IMP dehydrogenase activity
BBN63_RS02135	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBN63_RS02135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BBN63_RS02145	COG3458	cephalosporin-C deacetylase activity
BBN63_RS02155	COG1174	glycine betaine transport
BBN63_RS02160	COG1174	glycine betaine transport
BBN63_RS02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBN63_RS02170	COG2267	carboxylic ester hydrolase activity
BBN63_RS02185	COG0789	Transcriptional regulator
BBN63_RS02190	COG1846	Transcriptional regulator
BBN63_RS02190	COG1940	carbohydrate kinase activity
BBN63_RS02200	COG0366	Alpha amylase catalytic
BBN63_RS02205	COG1802	Transcriptional regulator
BBN63_RS02210	COG3507	Belongs to the glycosyl hydrolase 43 family
BBN63_RS02240	COG0662	Cupin 2, conserved barrel domain protein
BBN63_RS02260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BBN63_RS02265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBN63_RS02270	COG0181	hydroxymethylbilane synthase activity
BBN63_RS02305	COG1653	transport
BBN63_RS02340	COG0542	response to heat
BBN63_RS02355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BBN63_RS02360	COG0443	Heat shock 70 kDa protein
BBN63_RS02375	COG2208	phosphoserine phosphatase activity
BBN63_RS02375	COG2770	Histidine kinase
BBN63_RS02400	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS02405	COG0656	L-ascorbic acid biosynthetic process
BBN63_RS02475	COG1414	Transcriptional regulator
BBN63_RS02480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BBN63_RS02485	COG0277	FAD linked oxidase domain protein
BBN63_RS02485	COG0247	lactate metabolic process
BBN63_RS02490	COG1902	pentaerythritol trinitrate reductase activity
BBN63_RS02490	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBN63_RS02520	COG0246	Mannitol dehydrogenase
BBN63_RS02525	COG0477	Major facilitator Superfamily
BBN63_RS02530	COG1063	alcohol dehydrogenase
BBN63_RS02545	COG0501	Belongs to the peptidase M48B family
BBN63_RS02555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBN63_RS02570	COG3631	Ketosteroid isomerase-related protein
BBN63_RS02575	COG0702	epimerase
BBN63_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS02595	COG0789	Transcriptional regulator
BBN63_RS02600	COG0640	Transcriptional regulator
BBN63_RS02625	COG4948	Mandelate Racemase Muconate Lactonizing
BBN63_RS02640	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS02645	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS02650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS02655	COG0601	transmembrane transport
BBN63_RS02660	COG4166	transmembrane transport
BBN63_RS02665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBN63_RS02670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBN63_RS02675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBN63_RS02710	COG0789	Transcriptional regulator
BBN63_RS02800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BBN63_RS02830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BBN63_RS02840	COG1228	amidohydrolase
BBN63_RS02845	COG3251	PFAM MbtH domain protein
BBN63_RS02850	COG2382	esterase
BBN63_RS02855	COG1132	(ABC) transporter
BBN63_RS02865	COG1132	(ABC) transporter
BBN63_RS02870	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BBN63_RS02875	COG1120	ATPase activity
BBN63_RS02880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS02885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS02890	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BBN63_RS02915	COG0583	DNA-binding transcription factor activity
BBN63_RS02935	COG1131	(ABC) transporter
BBN63_RS02950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BBN63_RS02950	COG2070	2-Nitropropane dioxygenase
BBN63_RS02955	COG0604	alcohol dehydrogenase
BBN63_RS02955	COG3321	synthase
BBN63_RS02995	COG1302	Protein conserved in bacteria
BBN63_RS03040	COG2890	protein-(glutamine-N5) methyltransferase activity
BBN63_RS03050	COG2197	response regulator
BBN63_RS03055	COG1132	(ABC) transporter
BBN63_RS03060	COG1132	(ABC) transporter
BBN63_RS03070	COG0515	serine threonine protein kinase
BBN63_RS03110	COG4249	Peptidase C14 caspase catalytic subunit p20
BBN63_RS03110	COG2319	Wd-40 repeat
BBN63_RS03160	COG2378	regulation of single-species biofilm formation
BBN63_RS03175	COG2409	Drug exporters of the RND superfamily
BBN63_RS03180	COG4585	Histidine kinase
BBN63_RS03185	COG2197	response regulator
BBN63_RS03205	COG0596	Alpha beta hydrolase
BBN63_RS03210	COG0667	Aldo Keto reductase
BBN63_RS03230	COG3903	Transcriptional regulator
BBN63_RS03230	COG3629	intracellular signal transduction
BBN63_RS03250	COG2311	Membrane
BBN63_RS03270	COG1349	DNA-binding transcription factor activity
BBN63_RS03305	COG1136	(ABC) transporter
BBN63_RS03310	COG1136	(ABC) transporter
BBN63_RS03340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBN63_RS03435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BBN63_RS03465	COG2066	Belongs to the glutaminase family
BBN63_RS03485	COG1335	isochorismatase
BBN63_RS03505	COG1793	dna ligase
BBN63_RS03505	COG3285	dna ligase
BBN63_RS03550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBN63_RS03560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBN63_RS03565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBN63_RS03570	COG0183	Belongs to the thiolase family
BBN63_RS03580	COG1609	Transcriptional regulator
BBN63_RS03605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BBN63_RS03610	COG0121	glutamine amidotransferase
BBN63_RS03615	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BBN63_RS03630	COG2182	Extracellular solute-binding protein
BBN63_RS03645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBN63_RS03650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBN63_RS03655	COG1053	succinate dehydrogenase
BBN63_RS03670	COG5001	Diguanylate cyclase
BBN63_RS03670	COG3300	MHYT domain
BBN63_RS03740	COG3275	phosphorelay sensor kinase activity
BBN63_RS03745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBN63_RS03755	COG3279	Response regulator of the LytR AlgR family
BBN63_RS03765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBN63_RS03770	COG3618	amidohydrolase
BBN63_RS03810	COG1063	alcohol dehydrogenase
BBN63_RS03820	COG1609	Transcriptional regulator
BBN63_RS03825	COG1879	ABC-type sugar transport system periplasmic component
BBN63_RS03830	COG1129	ABC transporter
BBN63_RS03835	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS03840	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS03845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBN63_RS03850	COG0297	glycogen (starch) synthase activity
BBN63_RS03890	COG1175	transmembrane transport
BBN63_RS03895	COG0395	ABC-type sugar transport system, permease component
BBN63_RS03900	COG2723	6-phospho-beta-galactosidase activity
BBN63_RS03910	COG1063	alcohol dehydrogenase
BBN63_RS03920	COG1175	transmembrane transport
BBN63_RS03930	COG1349	DNA-binding transcription factor activity
BBN63_RS03945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BBN63_RS03975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BBN63_RS03990	COG2226	methyltransferase
BBN63_RS03995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BBN63_RS04005	COG1309	transcriptional regulator
BBN63_RS04015	COG0515	serine threonine protein kinase
BBN63_RS04015	COG2815	serine threonine protein kinase
BBN63_RS04040	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS04045	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS04050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS04055	COG0601	transmembrane transport
BBN63_RS04060	COG4166	transmembrane transport
BBN63_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS04185	COG1556	Lactate utilization protein
BBN63_RS04190	COG1139	Iron-sulfur cluster binding protein
BBN63_RS04195	COG0247	lactate metabolic process
BBN63_RS04220	COG1129	ABC transporter
BBN63_RS04230	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS04240	COG3254	rhamnose metabolic process
BBN63_RS04250	COG1609	Transcriptional regulator
BBN63_RS04310	COG1175	transmembrane transport
BBN63_RS04330	COG3458	cephalosporin-C deacetylase activity
BBN63_RS04345	COG0640	Transcriptional regulator
BBN63_RS04350	COG0798	PFAM Bile acid sodium symporter
BBN63_RS04355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBN63_RS04390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBN63_RS04395	COG3938	Belongs to the proline racemase family
BBN63_RS04405	COG1309	transcriptional regulator
BBN63_RS04460	COG1116	anion transmembrane transporter activity
BBN63_RS04470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBN63_RS04510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBN63_RS04520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBN63_RS04530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBN63_RS04575	COG2755	lipolytic protein G-D-S-L family
BBN63_RS04585	COG2365	Tyrosine phosphatase family
BBN63_RS04615	COG1657	PFAM Prenyltransferase squalene oxidase
BBN63_RS04625	COG1233	COG1233 Phytoene dehydrogenase and related
BBN63_RS04635	COG1562	ergosterol biosynthetic process
BBN63_RS04645	COG2409	Drug exporters of the RND superfamily
BBN63_RS04650	COG1134	teichoic acid transport
BBN63_RS04670	COG0371	Dehydrogenase
BBN63_RS04700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BBN63_RS04710	COG1024	Enoyl-CoA hydratase
BBN63_RS04720	COG2183	response to ionizing radiation
BBN63_RS04725	COG0488	(ABC) transporter
BBN63_RS04740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBN63_RS04770	COG0395	ABC-type sugar transport system, permease component
BBN63_RS04780	COG2890	protein-(glutamine-N5) methyltransferase activity
BBN63_RS04785	COG0789	Transcriptional regulator
BBN63_RS04790	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBN63_RS04790	COG1024	Enoyl-CoA hydratase
BBN63_RS04795	COG0183	Belongs to the thiolase family
BBN63_RS04800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BBN63_RS04805	COG3268	Saccharopine dehydrogenase
BBN63_RS04810	COG1515	deoxyribonuclease V activity
BBN63_RS04825	COG0488	(ABC) transporter
BBN63_RS04830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBN63_RS04835	COG1834	amidinotransferase
BBN63_RS04880	COG1793	dna ligase
BBN63_RS04885	COG3012	SEC-C Motif Domain Protein
BBN63_RS04920	COG0800	Aldolase
BBN63_RS04930	COG4948	Mandelate Racemase Muconate Lactonizing
BBN63_RS04935	COG2186	Transcriptional regulator
BBN63_RS04950	COG0395	ABC-type sugar transport system, permease component
BBN63_RS04955	COG1175	transmembrane transport
BBN63_RS04960	COG1653	transport
BBN63_RS04965	COG3345	alpha-galactosidase
BBN63_RS04970	COG1940	carbohydrate kinase activity
BBN63_RS04985	COG1070	Carbohydrate kinase
BBN63_RS05010	COG0156	8-amino-7-oxononanoate synthase activity
BBN63_RS05015	COG1063	alcohol dehydrogenase
BBN63_RS05025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBN63_RS05090	COG2274	protein secretion by the type I secretion system
BBN63_RS05095	COG2274	protein secretion by the type I secretion system
BBN63_RS05100	COG0277	FAD linked oxidase domain protein
BBN63_RS05110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBN63_RS05120	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BBN63_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS05150	COG0045	succinate-CoA ligase (ADP-forming) activity
BBN63_RS05160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BBN63_RS05170	COG2223	nitrite transmembrane transporter activity
BBN63_RS05205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BBN63_RS05230	COG0673	inositol 2-dehydrogenase activity
BBN63_RS05240	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS05245	COG1129	ABC transporter
BBN63_RS05260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBN63_RS05270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBN63_RS05275	COG3383	formate dehydrogenase (NAD+) activity
BBN63_RS05280	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BBN63_RS05290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BBN63_RS05300	COG0583	DNA-binding transcription factor activity
BBN63_RS05315	COG0789	Transcriptional regulator
BBN63_RS05335	COG2154	pterin-4-alpha-carbinolamine dehydratase
BBN63_RS05340	COG1252	NADH dehydrogenase
BBN63_RS05370	COG0693	protein deglycase activity
BBN63_RS05375	COG3958	Transketolase
BBN63_RS05455	COG1619	proteins homologs of microcin C7 resistance protein MccF
BBN63_RS05460	COG0823	Involved in the tonB-independent uptake of proteins
BBN63_RS05460	COG4946	Tricorn protease homolog
BBN63_RS05460	COG1506	peptidase
BBN63_RS05465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBN63_RS05470	COG2362	D-Aminopeptidase
BBN63_RS05480	COG2208	phosphoserine phosphatase activity
BBN63_RS05480	COG1366	Belongs to the anti-sigma-factor antagonist family
BBN63_RS05480	COG2172	sigma factor antagonist activity
BBN63_RS05525	COG0604	alcohol dehydrogenase
BBN63_RS05530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBN63_RS05530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBN63_RS05535	COG2301	Belongs to the HpcH HpaI aldolase family
BBN63_RS05545	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS05550	COG0688	phosphatidylethanolamine metabolic process
BBN63_RS05565	COG0559	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS05570	COG0559	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS05610	COG1929	Belongs to the glycerate kinase type-1 family
BBN63_RS05615	COG0494	nUDIX hydrolase
BBN63_RS05625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBN63_RS05645	COG0483	inositol monophosphate 1-phosphatase activity
BBN63_RS05660	COG1695	Transcriptional regulator
BBN63_RS05680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBN63_RS05685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BBN63_RS05715	COG0405	Gamma-glutamyltransferase
BBN63_RS05735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BBN63_RS05740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BBN63_RS05775	COG2409	Drug exporters of the RND superfamily
BBN63_RS05780	COG1595	DNA-templated transcription, initiation
BBN63_RS05825	COG0655	NAD(P)H dehydrogenase (quinone) activity
BBN63_RS05835	COG3424	synthase
BBN63_RS05850	COG0277	FAD linked oxidase domain protein
BBN63_RS05865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBN63_RS05880	COG1940	carbohydrate kinase activity
BBN63_RS05885	COG1129	ABC transporter
BBN63_RS05905	COG2188	Transcriptional regulator
BBN63_RS05910	COG0673	inositol 2-dehydrogenase activity
BBN63_RS05925	COG2197	response regulator
BBN63_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS05940	COG4266	Belongs to the allantoicase family
BBN63_RS05945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBN63_RS05950	COG1414	Transcriptional regulator
BBN63_RS05965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BBN63_RS06010	COG2233	PERMEase
BBN63_RS06025	COG2351	hydroxyisourate hydrolase activity
BBN63_RS06045	COG3622	Belongs to the hyi family
BBN63_RS06050	COG2084	Dehydrogenase
BBN63_RS06060	COG3960	tartronate-semialdehyde synthase activity
BBN63_RS06075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBN63_RS06080	COG2197	response regulator
BBN63_RS06105	COG2273	Hydrolase Family 16
BBN63_RS06105	COG5297	Belongs to the glycosyl hydrolase family 6
BBN63_RS06110	COG2197	response regulator
BBN63_RS06130	COG2252	PERMEase
BBN63_RS06135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BBN63_RS06150	COG3835	regulator
BBN63_RS06165	COG1802	Transcriptional regulator
BBN63_RS06190	COG0028	Belongs to the TPP enzyme family
BBN63_RS06210	COG1196	nuclear chromosome segregation
BBN63_RS06210	COG0741	lytic transglycosylase activity
BBN63_RS06210	COG0739	heme binding
BBN63_RS06230	COG2124	cytochrome p450
BBN63_RS06240	COG0142	geranyltranstransferase activity
BBN63_RS06260	COG2018	Roadblock/LC7 domain
BBN63_RS06280	COG1162	GTPase activity
BBN63_RS06325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBN63_RS06345	COG0640	Transcriptional regulator
BBN63_RS06365	COG2813	Specifically methylates the guanine in position
BBN63_RS06370	COG2318	DinB family
BBN63_RS06395	COG1486	melibiose metabolic process
BBN63_RS06430	COG0535	radical SAM domain protein
BBN63_RS06470	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS06490	COG0175	sulfate reduction
BBN63_RS06495	COG0529	Catalyzes the synthesis of activated sulfate
BBN63_RS06515	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BBN63_RS06520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBN63_RS06530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBN63_RS06535	COG2770	Histidine kinase
BBN63_RS06535	COG2208	phosphoserine phosphatase activity
BBN63_RS06550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBN63_RS06570	COG3415	Transposase
BBN63_RS06570	COG2801	Transposase and inactivated derivatives
BBN63_RS06590	COG2409	Drug exporters of the RND superfamily
BBN63_RS06600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BBN63_RS06620	COG1175	transmembrane transport
BBN63_RS06650	COG1716	ATPase activity
BBN63_RS06665	COG0667	Aldo Keto reductase
BBN63_RS06670	COG0574	Belongs to the PEP-utilizing enzyme family
BBN63_RS06670	COG3848	Pyruvate phosphate dikinase
BBN63_RS06685	COG0346	lactoylglutathione lyase activity
BBN63_RS06715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBN63_RS06720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBN63_RS06755	COG2268	Band 7 protein
BBN63_RS06785	COG3220	belongs to the UPF0276 family
BBN63_RS06800	COG3253	May function as heme-dependent peroxidase
BBN63_RS06805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BBN63_RS06815	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBN63_RS06820	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BBN63_RS06840	COG0183	Belongs to the thiolase family
BBN63_RS06845	COG1024	Enoyl-CoA hydratase
BBN63_RS06845	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBN63_RS06865	COG0531	amino acid
BBN63_RS06870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBN63_RS06875	COG4214	carbohydrate transport
BBN63_RS06885	COG4213	ABC transporter substrate-binding protein
BBN63_RS06890	COG1940	carbohydrate kinase activity
BBN63_RS06895	COG0395	ABC-type sugar transport system, permease component
BBN63_RS06900	COG1175	transmembrane transport
BBN63_RS06905	COG1653	transport
BBN63_RS06915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BBN63_RS06935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBN63_RS06975	COG4171	peptide transport system, permease
BBN63_RS06980	COG0601	transmembrane transport
BBN63_RS06985	COG4166	transmembrane transport
BBN63_RS07000	COG0019	diaminopimelate decarboxylase activity
BBN63_RS07005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBN63_RS07010	COG0534	Mate efflux family protein
BBN63_RS07020	COG2197	response regulator
BBN63_RS07030	COG1501	Belongs to the glycosyl hydrolase 31 family
BBN63_RS07040	COG0395	ABC-type sugar transport system, permease component
BBN63_RS07045	COG1175	transmembrane transport
BBN63_RS07055	COG1609	Transcriptional regulator
BBN63_RS07070	COG1136	(ABC) transporter
BBN63_RS07100	COG3250	beta-galactosidase activity
BBN63_RS07130	COG1024	Enoyl-CoA hydratase
BBN63_RS07140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BBN63_RS07150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BBN63_RS07160	COG2040	homocysteine
BBN63_RS07180	COG1799	cell septum assembly
BBN63_RS07185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBN63_RS07210	COG1090	epimerase
BBN63_RS07215	COG1309	transcriptional regulator
BBN63_RS07250	COG2409	Drug exporters of the RND superfamily
BBN63_RS07260	COG2391	methyltransferase activity
BBN63_RS07280	COG3953	SLT domain
BBN63_RS07280	COG5280	Phage tail tape measure protein TP901
BBN63_RS07315	COG2304	oxidoreductase activity
BBN63_RS07320	COG1064	alcohol dehydrogenase
BBN63_RS07325	COG1309	transcriptional regulator
BBN63_RS07345	COG2197	response regulator
BBN63_RS07360	COG0464	growth
BBN63_RS07430	COG0667	Aldo Keto reductase
BBN63_RS07435	COG0604	alcohol dehydrogenase
BBN63_RS07480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBN63_RS07490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBN63_RS07525	COG0288	reversible hydration of carbon dioxide
BBN63_RS07530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBN63_RS07530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBN63_RS07585	COG4941	Belongs to the sigma-70 factor family
BBN63_RS07590	COG3795	YCII-related domain
BBN63_RS07610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBN63_RS07675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBN63_RS07680	COG0531	amino acid
BBN63_RS07685	COG2409	Drug exporters of the RND superfamily
BBN63_RS07700	COG0569	domain protein
BBN63_RS07730	COG1136	(ABC) transporter
BBN63_RS07730	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBN63_RS07740	COG0756	dUTP diphosphatase activity
BBN63_RS07765	COG2205	protein histidine kinase activity
BBN63_RS07770	COG0745	RESPONSE REGULATOR receiver
BBN63_RS07780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BBN63_RS07845	COG1435	thymidine kinase activity
BBN63_RS07865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBN63_RS07880	COG0612	Peptidase, M16
BBN63_RS07885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBN63_RS07895	COG0366	Alpha amylase catalytic
BBN63_RS07905	COG1175	transmembrane transport
BBN63_RS07920	COG4733	cellulase activity
BBN63_RS07920	COG5297	Belongs to the glycosyl hydrolase family 6
BBN63_RS07925	COG3290	protein histidine kinase activity
BBN63_RS07930	COG4565	transcriptional regulatory protein
BBN63_RS07935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBN63_RS07945	COG2197	response regulator
BBN63_RS07950	COG4585	Histidine kinase
BBN63_RS07970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBN63_RS07975	COG1802	Transcriptional regulator
BBN63_RS08010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBN63_RS08060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBN63_RS08065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBN63_RS08070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BBN63_RS08110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBN63_RS08120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBN63_RS08125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBN63_RS08135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BBN63_RS08160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBN63_RS08175	COG0642	Histidine kinase
BBN63_RS08180	COG0745	RESPONSE REGULATOR receiver
BBN63_RS08185	COG1126	abc transporter atp-binding protein
BBN63_RS08190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBN63_RS08195	COG0765	amino acid transport
BBN63_RS08200	COG0765	amino acid transport
BBN63_RS08205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBN63_RS08225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BBN63_RS08235	COG1136	(ABC) transporter
BBN63_RS08235	COG0577	efflux transmembrane transporter activity
BBN63_RS08245	COG2197	response regulator
BBN63_RS08275	COG1201	RNA secondary structure unwinding
BBN63_RS08280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBN63_RS08290	COG0783	Belongs to the Dps family
BBN63_RS08295	COG1396	sequence-specific DNA binding
BBN63_RS08300	COG1058	Belongs to the CinA family
BBN63_RS08300	COG1546	Belongs to the CinA family
BBN63_RS08310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBN63_RS08320	COG1674	ftsk spoiiie
BBN63_RS08330	COG4999	Histidine kinase
BBN63_RS08330	COG3437	response regulator, receiver
BBN63_RS08330	COG3850	Histidine kinase
BBN63_RS08330	COG2205	protein histidine kinase activity
BBN63_RS08335	COG2770	Histidine kinase
BBN63_RS08335	COG2208	phosphoserine phosphatase activity
BBN63_RS08365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBN63_RS08370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBN63_RS08375	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BBN63_RS08400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BBN63_RS08405	COG0612	Peptidase, M16
BBN63_RS08410	COG1185	polyribonucleotide nucleotidyltransferase activity
BBN63_RS08415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BBN63_RS08425	COG1674	ftsk spoiiie
BBN63_RS08455	COG1404	Belongs to the peptidase S8 family
BBN63_RS08470	COG3266	domain, Protein
BBN63_RS08490	COG0455	bacterial-type flagellum organization
BBN63_RS08495	COG0747	negative chemotaxis
BBN63_RS08500	COG0601	transmembrane transport
BBN63_RS08505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS08515	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS08525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BBN63_RS08530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BBN63_RS08540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BBN63_RS08555	COG0779	Required for maturation of 30S ribosomal subunits
BBN63_RS08575	COG0442	prolyl-tRNA aminoacylation
BBN63_RS08590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BBN63_RS08595	COG0750	zinc metalloprotease
BBN63_RS08600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BBN63_RS08620	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS08625	COG2508	Transcriptional regulator
BBN63_RS08655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBN63_RS08660	COG1177	transmembrane transport
BBN63_RS08665	COG1176	ABC-type spermidine putrescine transport system, permease component I
BBN63_RS08670	COG3842	ATPase activity
BBN63_RS08695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BBN63_RS08700	COG0584	glycerophosphoryl diester phosphodiesterase
BBN63_RS08710	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS08720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BBN63_RS08725	COG1136	(ABC) transporter
BBN63_RS08740	COG3842	ATPase activity
BBN63_RS08745	COG1177	transmembrane transport
BBN63_RS08755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BBN63_RS08765	COG0233	cytoplasmic translational termination
BBN63_RS08770	COG0528	UMP kinase activity
BBN63_RS08775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BBN63_RS08780	COG0052	Belongs to the universal ribosomal protein uS2 family
BBN63_RS08795	COG1191	sigma factor activity
BBN63_RS08840	COG0792	nuclease activity
BBN63_RS08850	COG1051	belongs to the nudix hydrolase family
BBN63_RS08855	COG0681	Belongs to the peptidase S26 family
BBN63_RS08860	COG0681	Belongs to the peptidase S26 family
BBN63_RS08875	COG0335	large ribosomal subunit rRNA binding
BBN63_RS08880	COG0336	Belongs to the RNA methyltransferase TrmD family
BBN63_RS08885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BBN63_RS08890	COG1837	Belongs to the UPF0109 family
BBN63_RS08895	COG0228	four-way junction DNA binding
BBN63_RS08930	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BBN63_RS08935	COG0626	cystathionine gamma-synthase activity
BBN63_RS08940	COG3457	Alanine racemase
BBN63_RS08945	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BBN63_RS08955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBN63_RS08985	COG0477	Major facilitator Superfamily
BBN63_RS09000	COG1254	Belongs to the acylphosphatase family
BBN63_RS09010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBN63_RS09015	COG0571	ribonuclease III activity
BBN63_RS09020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BBN63_RS09035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BBN63_RS09040	COG0742	ribosomal rna small subunit methyltransferase
BBN63_RS09055	COG1461	Dihydroxyacetone kinase
BBN63_RS09060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BBN63_RS09065	COG0351	phosphomethylpyrimidine kinase
BBN63_RS09085	COG1181	Belongs to the D-alanine--D-alanine ligase family
BBN63_RS09090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BBN63_RS09100	COG1920	GTP binding
BBN63_RS09110	COG0776	regulation of translation
BBN63_RS09120	COG0066	3-isopropylmalate dehydratase activity
BBN63_RS09125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BBN63_RS09130	COG1414	Transcriptional regulator
BBN63_RS09170	COG0546	phosphoglycolate phosphatase activity
BBN63_RS09180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BBN63_RS09185	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBN63_RS09190	COG5002	protein histidine kinase activity
BBN63_RS09195	COG2018	Roadblock/LC7 domain
BBN63_RS09215	COG2018	Roadblock/LC7 domain
BBN63_RS09235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBN63_RS09245	COG2353	YceI-like domain
BBN63_RS09265	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS09270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS09275	COG0601	transmembrane transport
BBN63_RS09280	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS09300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BBN63_RS09310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBN63_RS09315	COG0473	3-isopropylmalate dehydrogenase activity
BBN63_RS09330	COG0575	Belongs to the CDS family
BBN63_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS09350	COG0506	proline dehydrogenase activity
BBN63_RS09355	COG3835	regulator
BBN63_RS09360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBN63_RS09370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBN63_RS09375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BBN63_RS09380	COG0440	acetolactate synthase activity
BBN63_RS09400	COG0667	Aldo Keto reductase
BBN63_RS09405	COG2133	pyrroloquinoline quinone binding
BBN63_RS09410	COG2197	response regulator
BBN63_RS09420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBN63_RS09425	COG2409	Drug exporters of the RND superfamily
BBN63_RS09430	COG3511	phospholipase C
BBN63_RS09450	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BBN63_RS09455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BBN63_RS09465	COG0154	amidase activity
BBN63_RS09470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BBN63_RS09480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BBN63_RS09495	COG1611	Belongs to the LOG family
BBN63_RS09520	COG0482	sulfurtransferase activity
BBN63_RS09535	COG2318	DinB family
BBN63_RS09550	COG2860	membrane
BBN63_RS09560	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS09565	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS09570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS09575	COG0601	transmembrane transport
BBN63_RS09580	COG0747	negative chemotaxis
BBN63_RS09605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BBN63_RS09610	COG0509	glycine decarboxylation via glycine cleavage system
BBN63_RS09615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BBN63_RS09620	COG1760	l-serine dehydratase
BBN63_RS09665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BBN63_RS09670	COG1073	alpha beta
BBN63_RS09670	COG2226	methyltransferase
BBN63_RS09680	COG2124	cytochrome p450
BBN63_RS09730	COG1024	Enoyl-CoA hydratase
BBN63_RS09740	COG1376	ErfK ybiS ycfS ynhG family protein
BBN63_RS09750	COG2197	response regulator
BBN63_RS09755	COG4585	Histidine kinase
BBN63_RS09765	COG1131	(ABC) transporter
BBN63_RS09770	COG1132	(ABC) transporter
BBN63_RS09775	COG1132	(ABC) transporter
BBN63_RS09780	COG2124	cytochrome p450
BBN63_RS09805	COG0058	SHG alpha-glucan phosphorylase activity
BBN63_RS09840	COG0366	Alpha amylase catalytic
BBN63_RS09845	COG0366	Alpha amylase catalytic
BBN63_RS09850	COG3281	Trehalose synthase
BBN63_RS09855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BBN63_RS09875	COG2188	Transcriptional regulator
BBN63_RS09895	COG1301	dicarboxylic acid transport
BBN63_RS09900	COG3290	protein histidine kinase activity
BBN63_RS09905	COG4565	transcriptional regulatory protein
BBN63_RS09920	COG1175	transmembrane transport
BBN63_RS09925	COG0395	ABC-type sugar transport system, permease component
BBN63_RS09930	COG0205	6-phosphofructokinase activity
BBN63_RS09935	COG0857	belongs to the CobB CobQ family
BBN63_RS09935	COG0280	phosphate acetyltransferase
BBN63_RS09940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBN63_RS09970	COG3118	belongs to the thioredoxin family
BBN63_RS09985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBN63_RS09985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBN63_RS10055	COG2205	protein histidine kinase activity
BBN63_RS10060	COG0745	RESPONSE REGULATOR receiver
BBN63_RS10075	COG0183	Belongs to the thiolase family
BBN63_RS10130	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
BBN63_RS10150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBN63_RS10165	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBN63_RS10195	COG4585	Histidine kinase
BBN63_RS10200	COG2197	response regulator
BBN63_RS10215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBN63_RS10220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BBN63_RS10225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BBN63_RS10230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BBN63_RS10235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBN63_RS10240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BBN63_RS10245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBN63_RS10265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBN63_RS10275	COG2890	protein-(glutamine-N5) methyltransferase activity
BBN63_RS10280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBN63_RS10285	COG0254	rRNA binding
BBN63_RS10290	COG1316	TRANSCRIPTIONal
BBN63_RS10305	COG0083	homoserine kinase activity
BBN63_RS10310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BBN63_RS10315	COG0460	homoserine dehydrogenase
BBN63_RS10320	COG0019	diaminopimelate decarboxylase activity
BBN63_RS10325	COG0018	arginyl-trna synthetase
BBN63_RS10375	COG1082	Xylose isomerase domain protein TIM barrel
BBN63_RS10385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BBN63_RS10390	COG1793	dna ligase
BBN63_RS10390	COG3285	dna ligase
BBN63_RS10410	COG0768	penicillin binding
BBN63_RS10485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BBN63_RS10505	COG0745	RESPONSE REGULATOR receiver
BBN63_RS10510	COG2205	protein histidine kinase activity
BBN63_RS10515	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBN63_RS10515	COG0567	Dehydrogenase, E1 component
BBN63_RS10585	COG0604	alcohol dehydrogenase
BBN63_RS10590	COG3540	Alkaline phosphatase
BBN63_RS10600	COG0281	malic enzyme
BBN63_RS10645	COG1191	sigma factor activity
BBN63_RS10665	COG2409	Drug exporters of the RND superfamily
BBN63_RS10700	COG0142	geranyltranstransferase activity
BBN63_RS10705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBN63_RS10715	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BBN63_RS10745	COG1597	lipid kinase activity
BBN63_RS10760	COG0363	glucosamine-6-phosphate deaminase activity
BBN63_RS10765	COG1472	Belongs to the glycosyl hydrolase 3 family
BBN63_RS10770	COG0395	ABC-type sugar transport system, permease component
BBN63_RS10780	COG2182	Extracellular solute-binding protein
BBN63_RS10785	COG2188	Transcriptional regulator
BBN63_RS10790	COG1966	Carbon starvation protein
BBN63_RS10810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBN63_RS10840	COG0242	peptide deformylase activity
BBN63_RS10855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BBN63_RS10855	COG2199	diguanylate cyclase activity
BBN63_RS10860	COG5662	AntiSigma factor
BBN63_RS10865	COG1595	DNA-templated transcription, initiation
BBN63_RS10875	COG2135	peptidase activity
BBN63_RS10890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BBN63_RS10895	COG1162	GTPase activity
BBN63_RS10910	COG0483	inositol monophosphate 1-phosphatase activity
BBN63_RS10920	COG0753	catalase activity
BBN63_RS10945	COG1615	UPF0182 protein
BBN63_RS10955	COG3480	Lon protease (S16) C-terminal proteolytic domain
BBN63_RS11010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BBN63_RS11045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBN63_RS11050	COG0210	DNA helicase
BBN63_RS11140	COG0513	Belongs to the DEAD box helicase family
BBN63_RS11145	COG2267	carboxylic ester hydrolase activity
BBN63_RS11150	COG1432	Conserved Protein
BBN63_RS11155	COG2095	MarC family integral membrane protein
BBN63_RS11180	COG0598	Magnesium transport protein CorA
BBN63_RS11215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBN63_RS11220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBN63_RS11230	COG1595	DNA-templated transcription, initiation
BBN63_RS11245	COG1024	Enoyl-CoA hydratase
BBN63_RS11250	COG0519	Catalyzes the synthesis of GMP from XMP
BBN63_RS11260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBN63_RS11265	COG1611	Belongs to the LOG family
BBN63_RS11270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBN63_RS11320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BBN63_RS11340	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS11350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS11355	COG0601	transmembrane transport
BBN63_RS11365	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS11370	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS11375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS11385	COG4166	transmembrane transport
BBN63_RS11390	COG1217	gtp-binding protein TYPA
BBN63_RS11420	COG2188	Transcriptional regulator
BBN63_RS11425	COG0477	Major facilitator Superfamily
BBN63_RS11445	COG1175	transmembrane transport
BBN63_RS11450	COG0395	ABC-type sugar transport system, permease component
BBN63_RS11505	COG3415	Transposase
BBN63_RS11505	COG2801	Transposase and inactivated derivatives
BBN63_RS11510	COG0012	GTP binding
BBN63_RS11525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BBN63_RS11535	COG1570	exodeoxyribonuclease VII activity
BBN63_RS11540	COG1722	exodeoxyribonuclease VII activity
BBN63_RS11545	COG0778	Nitroreductase
BBN63_RS11570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BBN63_RS11570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BBN63_RS11580	COG0114	fumarate hydratase activity
BBN63_RS11600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBN63_RS11615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BBN63_RS11635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BBN63_RS11640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BBN63_RS11645	COG0667	Aldo Keto reductase
BBN63_RS11705	COG2885	chlorophyll binding
BBN63_RS11725	COG2197	response regulator
BBN63_RS11760	COG2894	cell division
BBN63_RS11815	COG2610	gluconate transmembrane transporter activity
BBN63_RS11825	COG1414	Transcriptional regulator
BBN63_RS11840	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BBN63_RS11850	COG0436	Aminotransferase
BBN63_RS11875	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BBN63_RS11885	COG1309	transcriptional regulator
BBN63_RS11895	COG0463	Glycosyl transferase, family 2
BBN63_RS11910	COG1331	Highly conserved protein containing a thioredoxin domain
BBN63_RS11935	COG0740	serine-type endopeptidase activity
BBN63_RS11940	COG0740	serine-type endopeptidase activity
BBN63_RS11960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BBN63_RS11970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBN63_RS11985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBN63_RS11995	COG1595	DNA-templated transcription, initiation
BBN63_RS12025	COG3415	Transposase
BBN63_RS12025	COG2801	Transposase and inactivated derivatives
BBN63_RS12030	COG0488	(ABC) transporter
BBN63_RS12040	COG1376	ErfK ybiS ycfS ynhG family protein
BBN63_RS12065	COG1024	Enoyl-CoA hydratase
BBN63_RS12080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBN63_RS12090	COG0424	maF-like protein
BBN63_RS12100	COG4770	biotin carboxylase activity
BBN63_RS12105	COG1309	transcriptional regulator
BBN63_RS12110	COG1349	DNA-binding transcription factor activity
BBN63_RS12130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBN63_RS12140	COG2172	sigma factor antagonist activity
BBN63_RS12140	COG1366	Belongs to the anti-sigma-factor antagonist family
BBN63_RS12140	COG2208	phosphoserine phosphatase activity
BBN63_RS12150	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS12155	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS12170	COG1595	DNA-templated transcription, initiation
BBN63_RS12175	COG0745	RESPONSE REGULATOR receiver
BBN63_RS12180	COG2205	protein histidine kinase activity
BBN63_RS12205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BBN63_RS12215	COG0583	DNA-binding transcription factor activity
BBN63_RS12220	COG2814	Major facilitator Superfamily
BBN63_RS12250	COG1079	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS12260	COG3845	ABC transporter
BBN63_RS12265	COG1744	ABC transporter substrate-binding protein PnrA-like
BBN63_RS12270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BBN63_RS12270	COG1473	amidohydrolase
BBN63_RS12280	COG2089	acid synthase
BBN63_RS12295	COG1216	Glycosyl transferase, family 2
BBN63_RS12320	COG4257	antibiotic catabolic process
BBN63_RS12335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBN63_RS12335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBN63_RS12350	COG1595	DNA-templated transcription, initiation
BBN63_RS12360	COG3064	Membrane
BBN63_RS12360	COG3583	domain protein
BBN63_RS12360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BBN63_RS12370	COG2009	succinate dehydrogenase
BBN63_RS12380	COG1053	succinate dehydrogenase
BBN63_RS12385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBN63_RS12400	COG1309	transcriptional regulator
BBN63_RS12410	COG0745	RESPONSE REGULATOR receiver
BBN63_RS12415	COG2205	protein histidine kinase activity
BBN63_RS12420	COG1408	metallophosphoesterase
BBN63_RS12430	COG1686	Belongs to the peptidase S11 family
BBN63_RS12435	COG1295	ribonuclease BN
BBN63_RS12455	COG0180	Tryptophanyl-tRNA synthetase
BBN63_RS12460	COG1595	DNA-templated transcription, initiation
BBN63_RS12475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBN63_RS12480	COG0754	glutathionylspermidine amidase activity
BBN63_RS12495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBN63_RS12500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BBN63_RS12535	COG4176	ABC-type proline glycine betaine transport system permease component
BBN63_RS12540	COG4175	Glycine betaine
BBN63_RS12540	COG0517	IMP dehydrogenase activity
BBN63_RS12550	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS12565	COG0039	L-malate dehydrogenase activity
BBN63_RS12580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BBN63_RS12595	COG0515	serine threonine protein kinase
BBN63_RS12605	COG0138	bifunctional purine biosynthesis protein purh
BBN63_RS12635	COG0045	succinate-CoA ligase (ADP-forming) activity
BBN63_RS12640	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BBN63_RS12645	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BBN63_RS12650	COG0714	Associated with various cellular activities
BBN63_RS12665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBN63_RS12675	COG0739	heme binding
BBN63_RS12705	COG2197	response regulator
BBN63_RS12735	COG4106	trans-aconitate 2-methyltransferase activity
BBN63_RS12740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BBN63_RS12740	COG0519	Catalyzes the synthesis of GMP from XMP
BBN63_RS12760	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS12770	COG0515	serine threonine protein kinase
BBN63_RS12785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BBN63_RS12800	COG0516	GMP reductase activity
BBN63_RS12810	COG1595	DNA-templated transcription, initiation
BBN63_RS12825	COG0583	DNA-binding transcription factor activity
BBN63_RS12835	COG4221	oxidoreductase activity
BBN63_RS12855	COG0726	polysaccharide deacetylase
BBN63_RS12895	COG4941	Belongs to the sigma-70 factor family
BBN63_RS12910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BBN63_RS12935	COG0802	atpase or kinase
BBN63_RS12940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBN63_RS12945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBN63_RS12980	COG0736	holo-[acyl-carrier-protein] synthase activity
BBN63_RS12985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBN63_RS13020	COG1072	(Pantothenic acid kinase))
BBN63_RS13025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBN63_RS13030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BBN63_RS13035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BBN63_RS13040	COG0488	(ABC) transporter
BBN63_RS13050	COG0101	tRNA pseudouridine synthase activity
BBN63_RS13055	COG0203	ribosomal protein L17
BBN63_RS13060	COG0202	RNA polymerase activity
BBN63_RS13065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BBN63_RS13070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BBN63_RS13075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBN63_RS13080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BBN63_RS13090	COG0563	adenylate kinase activity
BBN63_RS13100	COG0200	Binds to the 23S rRNA
BBN63_RS13105	COG1841	ribosomal large subunit assembly
BBN63_RS13110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BBN63_RS13115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BBN63_RS13120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BBN63_RS13125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BBN63_RS13135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBN63_RS13140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BBN63_RS13145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BBN63_RS13150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BBN63_RS13155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BBN63_RS13160	COG0255	Belongs to the universal ribosomal protein uL29 family
BBN63_RS13165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BBN63_RS13170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BBN63_RS13175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BBN63_RS13180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BBN63_RS13185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BBN63_RS13190	COG0089	rRNA binding
BBN63_RS13195	COG0088	Forms part of the polypeptide exit tunnel
BBN63_RS13200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BBN63_RS13205	COG0051	transcription antitermination factor activity, RNA binding
BBN63_RS13215	COG2161	toxin-antitoxin pair type II binding
BBN63_RS13220	COG4115	mRNA cleavage
BBN63_RS13275	COG1051	belongs to the nudix hydrolase family
BBN63_RS13310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBN63_RS13315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BBN63_RS13320	COG0049	tRNA binding
BBN63_RS13325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BBN63_RS13330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BBN63_RS13335	COG0085	RNA polymerase activity
BBN63_RS13345	COG0222	ribosome binding
BBN63_RS13350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BBN63_RS13360	COG0081	regulation of translation
BBN63_RS13365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BBN63_RS13375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBN63_RS13385	COG0436	Aminotransferase
BBN63_RS13390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BBN63_RS13405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBN63_RS13410	COG0477	Major facilitator Superfamily
BBN63_RS13425	COG2030	dehydratase
BBN63_RS13430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BBN63_RS13445	COG0402	S-adenosylhomocysteine deaminase activity
BBN63_RS13450	COG0702	epimerase
BBN63_RS13460	COG1666	GTP binding
BBN63_RS13470	COG2261	transglycosylase associated protein
BBN63_RS13475	COG3304	Inner membrane component domain
BBN63_RS13480	COG0501	Belongs to the peptidase M48B family
BBN63_RS13485	COG1007	ATP synthesis coupled electron transport
BBN63_RS13500	COG0713	ATP synthesis coupled electron transport
BBN63_RS13510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBN63_RS13515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BBN63_RS13520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBN63_RS13525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBN63_RS13530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBN63_RS13550	COG0674	pyruvate-flavodoxin oxidoreductase activity
BBN63_RS13550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BBN63_RS13555	COG1013	pyruvate-flavodoxin oxidoreductase activity
BBN63_RS13570	COG1733	regulation of RNA biosynthetic process
BBN63_RS13590	COG1131	(ABC) transporter
BBN63_RS13600	COG0142	geranyltranstransferase activity
BBN63_RS13605	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBN63_RS13610	COG1007	ATP synthesis coupled electron transport
BBN63_RS13620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBN63_RS13625	COG0713	ATP synthesis coupled electron transport
BBN63_RS13630	COG0839	Belongs to the complex I subunit 6 family
BBN63_RS13635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBN63_RS13640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BBN63_RS13645	COG1034	ATP synthesis coupled electron transport
BBN63_RS13650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BBN63_RS13660	COG0649	NAD binding
BBN63_RS13665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBN63_RS13670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBN63_RS13680	COG0791	NLP P60 protein
BBN63_RS13685	COG3409	Peptidoglycan-binding domain 1 protein
BBN63_RS13685	COG3757	hydrolase, family 25
BBN63_RS13700	COG2226	methyltransferase
BBN63_RS13710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BBN63_RS13720	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BBN63_RS13725	COG1278	Cold shock
BBN63_RS13740	COG1309	transcriptional regulator
BBN63_RS13745	COG1301	dicarboxylic acid transport
BBN63_RS13760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BBN63_RS13770	COG0163	prenyltransferase activity
BBN63_RS13785	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BBN63_RS13795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBN63_RS13800	COG1333	cytochrome c biogenesis protein
BBN63_RS13810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBN63_RS13820	COG0406	alpha-ribazole phosphatase activity
BBN63_RS13825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BBN63_RS13870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BBN63_RS13875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BBN63_RS13880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BBN63_RS13975	COG1742	UPF0060 membrane protein
BBN63_RS13990	COG1357	PFAM Pentapeptide repeats (8 copies)
BBN63_RS14000	COG1690	Belongs to the RtcB family
BBN63_RS14025	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BBN63_RS14030	COG0018	arginyl-trna synthetase
BBN63_RS14035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BBN63_RS14110	COG0113	porphobilinogen synthase activity
BBN63_RS14115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BBN63_RS14115	COG1648	precorrin-2 dehydrogenase activity
BBN63_RS14120	COG0181	hydroxymethylbilane synthase activity
BBN63_RS14125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BBN63_RS14130	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BBN63_RS14180	COG0123	including yeast histone deacetylase and acetoin utilization protein
BBN63_RS14190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBN63_RS14215	COG0180	Tryptophanyl-tRNA synthetase
BBN63_RS14230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBN63_RS14240	COG1129	ABC transporter
BBN63_RS14240	COG0842	Transport permease protein
BBN63_RS14245	COG1595	DNA-templated transcription, initiation
BBN63_RS14260	COG4991	sh3 domain protein
BBN63_RS14270	COG0129	dihydroxy-acid dehydratase activity
BBN63_RS14280	COG1082	Xylose isomerase domain protein TIM barrel
BBN63_RS14285	COG0248	Ppx GppA phosphatase
BBN63_RS14305	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BBN63_RS14315	COG0671	phosphoesterase, PA-phosphatase related
BBN63_RS14320	COG1194	a g-specific adenine glycosylase
BBN63_RS14325	COG1595	DNA-templated transcription, initiation
BBN63_RS14335	COG0745	RESPONSE REGULATOR receiver
BBN63_RS14340	COG2205	protein histidine kinase activity
BBN63_RS14355	COG0739	heme binding
BBN63_RS14380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BBN63_RS14400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BBN63_RS14405	COG0157	Belongs to the NadC ModD family
BBN63_RS14410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BBN63_RS14415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BBN63_RS14430	COG0640	Transcriptional regulator
BBN63_RS14435	COG1660	Displays ATPase and GTPase activities
BBN63_RS14440	COG2197	response regulator
BBN63_RS14455	COG0649	NAD binding
BBN63_RS14465	COG1732	Glycine betaine
BBN63_RS14470	COG1174	glycine betaine transport
BBN63_RS14475	COG1174	glycine betaine transport
BBN63_RS14495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BBN63_RS14500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBN63_RS14510	COG0302	gtp cyclohydrolase
BBN63_RS14525	COG0037	tRNA processing
BBN63_RS14535	COG2027	D-alanyl-D-alanine carboxypeptidase
BBN63_RS14545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBN63_RS14555	COG0586	Pfam SNARE associated Golgi protein
BBN63_RS14565	COG0655	NAD(P)H dehydrogenase (quinone) activity
BBN63_RS14570	COG0076	glutamate decarboxylase activity
BBN63_RS14595	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS14630	COG3321	synthase
BBN63_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS14630	COG0604	alcohol dehydrogenase
BBN63_RS14645	COG1472	Belongs to the glycosyl hydrolase 3 family
BBN63_RS14705	COG0110	maltose O-acetyltransferase activity
BBN63_RS14715	COG4565	transcriptional regulatory protein
BBN63_RS14720	COG3290	protein histidine kinase activity
BBN63_RS14740	COG0589	response to stress
BBN63_RS14755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBN63_RS14760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BBN63_RS14765	COG1754	DNA topoisomerase type I activity
BBN63_RS14765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBN63_RS14780	COG2890	protein-(glutamine-N5) methyltransferase activity
BBN63_RS14790	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BBN63_RS14795	COG2172	sigma factor antagonist activity
BBN63_RS14800	COG1366	Belongs to the anti-sigma-factor antagonist family
BBN63_RS14805	COG1205	dead DEAH box helicase
BBN63_RS14805	COG1111	helicase
BBN63_RS14865	COG0659	secondary active sulfate transmembrane transporter activity
BBN63_RS14870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBN63_RS14875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBN63_RS14885	COG2267	carboxylic ester hydrolase activity
BBN63_RS14895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBN63_RS14915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBN63_RS14925	COG0251	oxidation-reduction process
BBN63_RS14935	COG0003	Pfam Anion-transporting ATPase
BBN63_RS14950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBN63_RS14955	COG1610	YqeY-like protein
BBN63_RS14960	COG1408	metallophosphoesterase
BBN63_RS15035	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS15075	COG1595	DNA-templated transcription, initiation
BBN63_RS15115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BBN63_RS15120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BBN63_RS15135	COG0463	Glycosyl transferase, family 2
BBN63_RS15140	COG1802	Transcriptional regulator
BBN63_RS15145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BBN63_RS15150	COG0693	protein deglycase activity
BBN63_RS15260	COG0701	Predicted permease
BBN63_RS15275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BBN63_RS15290	COG1131	(ABC) transporter
BBN63_RS15295	COG3559	Exporter of polyketide antibiotics
BBN63_RS15305	COG2197	response regulator
BBN63_RS15310	COG4585	Histidine kinase
BBN63_RS15315	COG0702	epimerase
BBN63_RS15350	COG3844	kynureninase activity
BBN63_RS15370	COG0477	Major facilitator Superfamily
BBN63_RS15375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBN63_RS15380	COG0191	fructose-bisphosphate aldolase activity
BBN63_RS15385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBN63_RS15400	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BBN63_RS15430	COG0542	response to heat
BBN63_RS15455	COG0789	Transcriptional regulator
BBN63_RS15460	COG0484	heat shock protein binding
BBN63_RS15465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BBN63_RS15470	COG0443	Heat shock 70 kDa protein
BBN63_RS15480	COG2181	nitrate reductase activity
BBN63_RS15480	COG0247	lactate metabolic process
BBN63_RS15500	COG0717	Belongs to the dCTP deaminase family
BBN63_RS15575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBN63_RS15585	COG0105	UTP biosynthetic process
BBN63_RS15635	COG1203	CRISPR-associated helicase, Cas3
BBN63_RS15720	COG1324	tolerance protein
BBN63_RS15760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BBN63_RS15765	COG2192	nodulation
BBN63_RS15780	COG2226	methyltransferase
BBN63_RS15800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBN63_RS15840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BBN63_RS15850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBN63_RS15895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BBN63_RS15975	COG3046	protein related to deoxyribodipyrimidine photolyase
BBN63_RS15985	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BBN63_RS15990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS15995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBN63_RS16025	COG4221	oxidoreductase activity
BBN63_RS16075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BBN63_RS16075	COG0519	Catalyzes the synthesis of GMP from XMP
BBN63_RS16085	COG0659	secondary active sulfate transmembrane transporter activity
BBN63_RS16135	COG2409	Drug exporters of the RND superfamily
BBN63_RS16145	COG0586	Pfam SNARE associated Golgi protein
BBN63_RS16150	COG0667	Aldo Keto reductase
BBN63_RS16190	COG0443	Heat shock 70 kDa protein
BBN63_RS16200	COG0515	serine threonine protein kinase
BBN63_RS16200	COG2815	serine threonine protein kinase
BBN63_RS16240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBN63_RS16250	COG2340	Cysteine-rich secretory protein family
BBN63_RS16280	COG5002	protein histidine kinase activity
BBN63_RS16285	COG0745	RESPONSE REGULATOR receiver
BBN63_RS16320	COG0531	amino acid
BBN63_RS16325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BBN63_RS16330	COG0174	glutamine synthetase
BBN63_RS16360	COG0019	diaminopimelate decarboxylase activity
BBN63_RS16375	COG3467	pyridoxamine 5'-phosphate
BBN63_RS16455	COG1672	PFAM Archaeal ATPase
BBN63_RS16455	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BBN63_RS16460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBN63_RS16465	COG0583	DNA-binding transcription factor activity
BBN63_RS16480	COG0431	NADPH-dependent FMN reductase
BBN63_RS16485	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS16500	COG1289	transmembrane transporter activity
BBN63_RS16515	COG0488	(ABC) transporter
BBN63_RS16545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BBN63_RS16600	COG2205	protein histidine kinase activity
BBN63_RS16605	COG0745	RESPONSE REGULATOR receiver
BBN63_RS16610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBN63_RS16635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BBN63_RS16650	COG1741	Belongs to the pirin family
BBN63_RS16670	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS16675	COG1362	aminopeptidase activity
BBN63_RS16735	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBN63_RS16740	COG0022	dehydrogenase e1 component
BBN63_RS16765	COG0515	serine threonine protein kinase
BBN63_RS16770	COG0515	serine threonine protein kinase
BBN63_RS16790	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBN63_RS16790	COG1136	(ABC) transporter
BBN63_RS16810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBN63_RS16845	COG1309	transcriptional regulator
BBN63_RS16850	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBN63_RS16875	COG3396	Phenylacetate-CoA oxygenase
BBN63_RS16880	COG3460	Phenylacetate-CoA oxygenase
BBN63_RS16885	COG3396	Phenylacetate-CoA oxygenase
BBN63_RS16890	COG2151	metal-sulfur cluster biosynthetic enzyme
BBN63_RS16895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BBN63_RS16915	COG1733	regulation of RNA biosynthetic process
BBN63_RS16920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BBN63_RS16930	COG1716	ATPase activity
BBN63_RS16935	COG1716	ATPase activity
BBN63_RS16950	COG0768	penicillin binding
BBN63_RS16960	COG0515	serine threonine protein kinase
BBN63_RS16965	COG3764	Sortase (surface protein transpeptidase)
BBN63_RS16970	COG3764	Sortase (surface protein transpeptidase)
BBN63_RS16990	COG0705	Rhomboid family
BBN63_RS16990	COG0457	Tetratricopeptide repeat
BBN63_RS17015	COG1309	transcriptional regulator
BBN63_RS17035	COG0515	serine threonine protein kinase
BBN63_RS17060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBN63_RS17070	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
BBN63_RS17075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BBN63_RS17080	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BBN63_RS17085	COG0592	DNA-directed DNA polymerase activity
BBN63_RS17100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BBN63_RS17105	COG0594	ribonuclease P activity
BBN63_RS17110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BBN63_RS17115	COG0706	membrane insertase activity
BBN63_RS17125	COG0357	Ribosomal RNA small subunit methyltransferase G
BBN63_RS17130	COG1192	Involved in chromosome partitioning
BBN63_RS17145	COG3118	belongs to the thioredoxin family
BBN63_RS17150	COG0492	ferredoxin-NADP+ reductase activity
BBN63_RS17160	COG1595	DNA-templated transcription, initiation
BBN63_RS17165	COG2815	serine threonine protein kinase
BBN63_RS17165	COG0515	serine threonine protein kinase
BBN63_RS17180	COG0617	tRNA 3'-terminal CCA addition
BBN63_RS17200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBN63_RS17225	COG0360	Binds together with S18 to 16S ribosomal RNA
BBN63_RS17230	COG0629	single-stranded DNA binding
BBN63_RS17235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BBN63_RS17240	COG0359	binds to the 23S rRNA
BBN63_RS17255	COG0305	Participates in initiation and elongation during chromosome replication
BBN63_RS17260	COG4941	Belongs to the sigma-70 factor family
BBN63_RS17265	COG3795	YCII-related domain
BBN63_RS17300	COG2814	Major facilitator Superfamily
BBN63_RS17325	COG0626	cystathionine gamma-synthase activity
BBN63_RS17330	COG1950	PFAM Membrane protein of
BBN63_RS17335	COG0662	Cupin 2, conserved barrel domain protein
BBN63_RS17360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BBN63_RS17380	COG1609	Transcriptional regulator
BBN63_RS17385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBN63_RS17390	COG1271	oxidase subunit
BBN63_RS17395	COG1294	oxidase, subunit
BBN63_RS17400	COG4988	ABC transporter
BBN63_RS17410	COG0561	phosphatase activity
BBN63_RS17420	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
BBN63_RS17445	COG1131	(ABC) transporter
BBN63_RS17470	COG0561	phosphatase activity
BBN63_RS17475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BBN63_RS17485	COG2837	iron assimilation
BBN63_RS17490	COG2372	response to copper ion
BBN63_RS17500	COG1999	signal sequence binding
BBN63_RS17520	COG0006	proline dipeptidase activity
BBN63_RS17540	COG0653	protein targeting
BBN63_RS17570	COG1024	Enoyl-CoA hydratase
BBN63_RS17570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BBN63_RS17620	COG2186	Transcriptional regulator
BBN63_RS17710	COG1595	DNA-templated transcription, initiation
BBN63_RS17715	COG0318	PFAM AMP-dependent synthetase and ligase
BBN63_RS17720	COG0745	RESPONSE REGULATOR receiver
BBN63_RS17780	COG2186	Transcriptional regulator
BBN63_RS17850	COG0745	RESPONSE REGULATOR receiver
BBN63_RS17855	COG2205	protein histidine kinase activity
BBN63_RS17865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BBN63_RS17875	COG3467	pyridoxamine 5'-phosphate
BBN63_RS17880	COG2353	YceI-like domain
BBN63_RS17885	COG0477	Major facilitator Superfamily
BBN63_RS17890	COG1846	Transcriptional regulator
BBN63_RS17900	COG1191	sigma factor activity
BBN63_RS17905	COG1191	sigma factor activity
BBN63_RS17940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BBN63_RS17975	COG4941	Belongs to the sigma-70 factor family
BBN63_RS17985	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS18015	COG0367	asparagine synthase
BBN63_RS18045	COG0596	Alpha beta hydrolase
BBN63_RS18055	COG0596	Alpha beta hydrolase
BBN63_RS18070	COG2197	response regulator
BBN63_RS18085	COG2084	Dehydrogenase
BBN63_RS18100	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BBN63_RS18140	COG3547	Transposase (IS116 IS110 IS902 family)
BBN63_RS18150	COG0515	serine threonine protein kinase
BBN63_RS18150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBN63_RS18200	COG2188	Transcriptional regulator
BBN63_RS18240	COG0305	Participates in initiation and elongation during chromosome replication
BBN63_RS18270	COG0151	Belongs to the GarS family
BBN63_RS18275	COG0501	Belongs to the peptidase M48B family
BBN63_RS18285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BBN63_RS18295	COG2197	response regulator
BBN63_RS18330	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBN63_RS18335	COG0047	phosphoribosylformylglycinamidine synthase activity
BBN63_RS18340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBN63_RS18360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BBN63_RS18370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBN63_RS18395	COG1643	Atp-dependent helicase
BBN63_RS18425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBN63_RS18430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBN63_RS18440	COG0513	Belongs to the DEAD box helicase family
BBN63_RS18475	COG3629	intracellular signal transduction
BBN63_RS18475	COG3903	Transcriptional regulator
BBN63_RS18480	COG0596	Alpha beta hydrolase
BBN63_RS18485	COG1309	transcriptional regulator
BBN63_RS18520	COG0789	Transcriptional regulator
BBN63_RS18530	COG1196	nuclear chromosome segregation
BBN63_RS18530	COG0739	heme binding
BBN63_RS18530	COG0741	lytic transglycosylase activity
BBN63_RS18540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BBN63_RS18545	COG0579	oxidoreductase
BBN63_RS18570	COG1252	NADH dehydrogenase
BBN63_RS18610	COG2197	response regulator
BBN63_RS18615	COG4585	Histidine kinase
BBN63_RS18625	COG1131	(ABC) transporter
BBN63_RS18685	COG0739	heme binding
BBN63_RS18685	COG0741	lytic transglycosylase activity
BBN63_RS18685	COG1196	nuclear chromosome segregation
BBN63_RS18690	COG0671	phosphoesterase, PA-phosphatase related
BBN63_RS18695	COG0277	FAD linked oxidase domain protein
BBN63_RS18710	COG1937	Protein conserved in bacteria
BBN63_RS18720	COG0306	phosphate transporter
BBN63_RS18765	COG1131	(ABC) transporter
BBN63_RS18770	COG1725	Transcriptional regulator
BBN63_RS18775	COG0456	acetyltransferase
BBN63_RS18785	COG0737	Belongs to the 5'-nucleotidase family
BBN63_RS18815	COG4106	trans-aconitate 2-methyltransferase activity
BBN63_RS18825	COG3634	alkyl hydroperoxide reductase activity
BBN63_RS18890	COG3655	Transcriptional regulator
BBN63_RS18920	COG2205	protein histidine kinase activity
BBN63_RS18930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBN63_RS18935	COG1609	Transcriptional regulator
BBN63_RS18940	COG0745	RESPONSE REGULATOR receiver
BBN63_RS18965	COG2897	thiosulfate sulfurtransferase activity
BBN63_RS19000	COG3485	protocatechuate 3,4-dioxygenase
BBN63_RS19005	COG0735	belongs to the Fur family
BBN63_RS19015	COG1490	D-aminoacyl-tRNA deacylase activity
BBN63_RS19030	COG4552	Acetyltransferase involved in intracellular survival and related
BBN63_RS19040	COG2186	Transcriptional regulator
BBN63_RS19050	COG0510	thiamine kinase activity
BBN63_RS19075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBN63_RS19115	COG0596	Alpha beta hydrolase
BBN63_RS19125	COG1090	epimerase
BBN63_RS19130	COG1595	DNA-templated transcription, initiation
BBN63_RS19135	COG0330	HflC and HflK could
BBN63_RS19140	COG2197	response regulator
BBN63_RS19150	COG1131	(ABC) transporter
BBN63_RS19195	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS19215	COG0588	phosphoglycerate mutase activity
BBN63_RS19225	COG5002	protein histidine kinase activity
BBN63_RS19245	COG1329	Transcriptional regulator
BBN63_RS19250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BBN63_RS19255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BBN63_RS19260	COG0259	pyridoxamine-phosphate oxidase activity
BBN63_RS19265	COG0215	cysteine-tRNA ligase activity
BBN63_RS19280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBN63_RS19290	COG3842	ATPase activity
BBN63_RS19300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBN63_RS19355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBN63_RS19390	COG1940	carbohydrate kinase activity
BBN63_RS19405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBN63_RS19405	COG1877	trehalose-phosphatase activity
BBN63_RS19415	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BBN63_RS19420	COG0463	Glycosyl transferase, family 2
BBN63_RS19440	COG0459	protein refolding
BBN63_RS19470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BBN63_RS19475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BBN63_RS19480	COG0789	Transcriptional regulator
BBN63_RS19505	COG1295	ribonuclease BN
BBN63_RS19530	COG1595	DNA-templated transcription, initiation
BBN63_RS19555	COG3142	Participates in the control of copper homeostasis
BBN63_RS19560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BBN63_RS19565	COG3973	AAA domain
BBN63_RS19580	COG1061	Type III restriction enzyme res subunit
BBN63_RS19610	COG1120	ATPase activity
BBN63_RS19615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS19620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS19635	COG1278	Cold shock
BBN63_RS19670	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BBN63_RS19675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BBN63_RS19685	COG2814	Major facilitator Superfamily
BBN63_RS19705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBN63_RS19715	COG2252	PERMEase
BBN63_RS19725	COG1846	Transcriptional regulator
BBN63_RS19745	COG0667	Aldo Keto reductase
BBN63_RS19750	COG2267	carboxylic ester hydrolase activity
BBN63_RS19790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BBN63_RS19795	COG0247	lactate metabolic process
BBN63_RS19795	COG0277	FAD linked oxidase domain protein
BBN63_RS19825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBN63_RS19830	COG0439	Biotin carboxylase
BBN63_RS19860	COG1136	(ABC) transporter
BBN63_RS19865	COG0577	efflux transmembrane transporter activity
BBN63_RS19865	COG1136	(ABC) transporter
BBN63_RS19895	COG0259	pyridoxamine-phosphate oxidase activity
BBN63_RS19905	COG4821	SIS domain
BBN63_RS19915	COG2945	thiolester hydrolase activity
BBN63_RS19915	COG0596	Alpha beta hydrolase
BBN63_RS19975	COG1366	Belongs to the anti-sigma-factor antagonist family
BBN63_RS20010	COG2271	Major facilitator Superfamily
BBN63_RS20015	COG2072	flavoprotein involved in K transport
BBN63_RS20040	COG1309	transcriptional regulator
BBN63_RS20050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBN63_RS20050	COG0515	serine threonine protein kinase
BBN63_RS20085	COG2318	DinB family
BBN63_RS20115	COG0577	efflux transmembrane transporter activity
BBN63_RS20115	COG1136	(ABC) transporter
BBN63_RS20130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BBN63_RS20160	COG1686	Belongs to the peptidase S11 family
BBN63_RS20190	COG2843	Capsule synthesis protein
BBN63_RS20255	COG2318	DinB family
BBN63_RS20260	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS20315	COG0517	IMP dehydrogenase activity
BBN63_RS20395	COG3629	intracellular signal transduction
BBN63_RS20395	COG3903	Transcriptional regulator
BBN63_RS20410	COG0515	serine threonine protein kinase
BBN63_RS20410	COG2815	serine threonine protein kinase
BBN63_RS20485	COG3903	Transcriptional regulator
BBN63_RS20485	COG3629	intracellular signal transduction
BBN63_RS20490	COG2409	Drug exporters of the RND superfamily
BBN63_RS20495	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BBN63_RS20505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBN63_RS20510	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BBN63_RS20530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BBN63_RS20545	COG0673	inositol 2-dehydrogenase activity
BBN63_RS20570	COG0142	geranyltranstransferase activity
BBN63_RS20575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BBN63_RS20600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBN63_RS20610	COG2326	polyphosphate kinase activity
BBN63_RS20615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBN63_RS20620	COG0135	phosphoribosylanthranilate isomerase activity
BBN63_RS20645	COG1846	Transcriptional regulator
BBN63_RS20650	COG3384	dioxygenase
BBN63_RS20660	COG1175	transmembrane transport
BBN63_RS20665	COG0395	ABC-type sugar transport system, permease component
BBN63_RS20670	COG1472	Belongs to the glycosyl hydrolase 3 family
BBN63_RS20675	COG1247	-acetyltransferase
BBN63_RS20690	COG0477	Major facilitator Superfamily
BBN63_RS20695	COG1349	DNA-binding transcription factor activity
BBN63_RS20700	COG1105	Belongs to the carbohydrate kinase PfkB family
BBN63_RS20705	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BBN63_RS20705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBN63_RS20705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBN63_RS20725	COG1970	mechanosensitive ion channel activity
BBN63_RS20735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BBN63_RS20760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBN63_RS20765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BBN63_RS20775	COG0315	cyclic pyranopterin monophosphate synthase activity
BBN63_RS20780	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBN63_RS20780	COG0315	cyclic pyranopterin monophosphate synthase activity
BBN63_RS20810	COG2031	fatty acid transporter
BBN63_RS20860	COG0297	glycogen (starch) synthase activity
BBN63_RS20865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBN63_RS20885	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS20955	COG2072	flavoprotein involved in K transport
BBN63_RS20960	COG2267	carboxylic ester hydrolase activity
BBN63_RS20965	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS20975	COG0793	Belongs to the peptidase S41A family
BBN63_RS20975	COG4946	Tricorn protease homolog
BBN63_RS20985	COG2409	Drug exporters of the RND superfamily
BBN63_RS20995	COG0310	cobalt ion transport
BBN63_RS21005	COG1122	ATPase activity
BBN63_RS21010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BBN63_RS21015	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS21020	COG0596	Alpha beta hydrolase
BBN63_RS21065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBN63_RS21075	COG0667	Aldo Keto reductase
BBN63_RS21105	COG1136	(ABC) transporter
BBN63_RS21105	COG0577	efflux transmembrane transporter activity
BBN63_RS21130	COG0442	prolyl-tRNA aminoacylation
BBN63_RS21150	COG0596	Alpha beta hydrolase
BBN63_RS21165	COG0477	Major facilitator Superfamily
BBN63_RS21175	COG0028	Belongs to the TPP enzyme family
BBN63_RS21180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BBN63_RS21185	COG2188	Transcriptional regulator
BBN63_RS21210	COG0084	hydrolase, TatD family'
BBN63_RS21220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BBN63_RS21225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BBN63_RS21245	COG0583	DNA-binding transcription factor activity
BBN63_RS21250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BBN63_RS21265	COG2318	DinB family
BBN63_RS21315	COG0488	(ABC) transporter
BBN63_RS21340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBN63_RS21355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBN63_RS21365	COG2197	response regulator
BBN63_RS21370	COG1846	Transcriptional regulator
BBN63_RS21375	COG4106	trans-aconitate 2-methyltransferase activity
BBN63_RS21400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BBN63_RS21410	COG0193	aminoacyl-tRNA hydrolase activity
BBN63_RS21415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BBN63_RS21420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BBN63_RS21425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BBN63_RS21435	COG4585	Histidine kinase
BBN63_RS21465	COG2814	Major facilitator Superfamily
BBN63_RS21470	COG1136	(ABC) transporter
BBN63_RS21475	COG0577	efflux transmembrane transporter activity
BBN63_RS21485	COG3903	Transcriptional regulator
BBN63_RS21485	COG3629	intracellular signal transduction
BBN63_RS21520	COG1131	(ABC) transporter
BBN63_RS21540	COG1473	amidohydrolase
BBN63_RS21575	COG2815	serine threonine protein kinase
BBN63_RS21575	COG0515	serine threonine protein kinase
BBN63_RS21585	COG0463	Glycosyl transferase, family 2
BBN63_RS21605	COG2124	cytochrome p450
BBN63_RS21620	COG0148	phosphopyruvate hydratase activity
BBN63_RS21645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBN63_RS21650	COG0577	efflux transmembrane transporter activity
BBN63_RS21650	COG1136	(ABC) transporter
BBN63_RS21655	COG1136	(ABC) transporter
BBN63_RS21685	COG0183	Belongs to the thiolase family
BBN63_RS21690	COG2755	lipolytic protein G-D-S-L family
BBN63_RS21780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BBN63_RS21795	COG1228	amidohydrolase
BBN63_RS21895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BBN63_RS21935	COG1191	sigma factor activity
BBN63_RS21950	COG3104	oligopeptide transport
BBN63_RS21955	COG0745	RESPONSE REGULATOR receiver
BBN63_RS21960	COG2205	protein histidine kinase activity
BBN63_RS21990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BBN63_RS22000	COG2318	DinB family
BBN63_RS22005	COG1316	TRANSCRIPTIONal
BBN63_RS22025	COG1316	TRANSCRIPTIONal
BBN63_RS22035	COG1316	TRANSCRIPTIONal
BBN63_RS22060	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
BBN63_RS22060	COG0778	Nitroreductase
BBN63_RS22065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BBN63_RS22105	COG1620	l-lactate permease
BBN63_RS22110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBN63_RS22115	COG2835	tetraacyldisaccharide 4'-kinase activity
BBN63_RS22125	COG1482	cell wall glycoprotein biosynthetic process
BBN63_RS22135	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BBN63_RS22180	COG0714	Associated with various cellular activities
BBN63_RS22200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BBN63_RS22205	COG0745	RESPONSE REGULATOR receiver
BBN63_RS22210	COG5002	protein histidine kinase activity
BBN63_RS22210	COG5000	phosphorelay sensor kinase activity
BBN63_RS22215	COG0823	Involved in the tonB-independent uptake of proteins
BBN63_RS22225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBN63_RS22230	COG2197	response regulator
BBN63_RS22235	COG3214	Protein conserved in bacteria
BBN63_RS22245	COG0653	protein targeting
BBN63_RS22265	COG2902	Dehydrogenase
BBN63_RS22270	COG1134	teichoic acid transport
BBN63_RS22280	COG1309	transcriptional regulator
BBN63_RS22290	COG2226	methyltransferase
BBN63_RS22290	COG1073	alpha beta
BBN63_RS22300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BBN63_RS22305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BBN63_RS22310	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS22325	COG2409	Drug exporters of the RND superfamily
BBN63_RS22350	COG0395	ABC-type sugar transport system, permease component
BBN63_RS22355	COG1175	transmembrane transport
BBN63_RS22370	COG0515	serine threonine protein kinase
BBN63_RS22375	COG0515	serine threonine protein kinase
BBN63_RS22380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBN63_RS22395	COG2884	Cell division ATP-binding protein ftsE
BBN63_RS22400	COG2177	Part of the ABC transporter FtsEX involved in
BBN63_RS22405	COG0793	Belongs to the peptidase S41A family
BBN63_RS22410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BBN63_RS22455	COG2223	nitrite transmembrane transporter activity
BBN63_RS22485	COG3973	AAA domain
BBN63_RS22485	COG3973	AAA domain
BBN63_RS22495	COG0776	regulation of translation
BBN63_RS22500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBN63_RS22505	COG1678	Uncharacterized ACR, COG1678
BBN63_RS22525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BBN63_RS22595	COG1174	glycine betaine transport
BBN63_RS22605	COG1174	glycine betaine transport
BBN63_RS22615	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BBN63_RS22625	COG0765	amino acid transport
BBN63_RS22630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBN63_RS22645	COG0277	FAD linked oxidase domain protein
BBN63_RS22685	COG1335	isochorismatase
BBN63_RS22700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BBN63_RS22710	COG1113	amino acid transport
BBN63_RS22725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS22730	COG1120	ATPase activity
BBN63_RS22755	COG1234	tRNA 3'-trailer cleavage
BBN63_RS22760	COG1263	PTS System
BBN63_RS22765	COG1263	PTS System
BBN63_RS22770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBN63_RS22775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BBN63_RS22785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BBN63_RS22860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBN63_RS22870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBN63_RS22885	COG4555	ABC transporter
BBN63_RS22900	COG2733	membrane
BBN63_RS23020	COG4702	Belongs to the UPF0303 family
BBN63_RS23025	COG0673	inositol 2-dehydrogenase activity
BBN63_RS23035	COG2124	cytochrome p450
BBN63_RS23100	COG3397	chitin binding
BBN63_RS23110	COG1126	abc transporter atp-binding protein
BBN63_RS23115	COG0765	amino acid transport
BBN63_RS23120	COG0765	amino acid transport
BBN63_RS23125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBN63_RS23135	COG0154	amidase activity
BBN63_RS23140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBN63_RS23155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBN63_RS23205	COG0406	alpha-ribazole phosphatase activity
BBN63_RS23220	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BBN63_RS23230	COG0745	RESPONSE REGULATOR receiver
BBN63_RS23265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BBN63_RS23270	COG4977	sequence-specific DNA binding
BBN63_RS23285	COG0589	response to stress
BBN63_RS23290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBN63_RS23335	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS23350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBN63_RS23355	COG1309	transcriptional regulator
BBN63_RS23370	COG1946	Acyl-CoA thioesterase
BBN63_RS23385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBN63_RS23395	COG0028	Belongs to the TPP enzyme family
BBN63_RS23415	COG1476	TRANSCRIPTIONal
BBN63_RS23450	COG1668	transmembrane transport
BBN63_RS23455	COG4152	abc transporter atp-binding protein
BBN63_RS23465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBN63_RS23470	COG1132	(ABC) transporter
BBN63_RS23500	COG1846	Transcriptional regulator
BBN63_RS23500	COG0456	acetyltransferase
BBN63_RS23505	COG1609	Transcriptional regulator
BBN63_RS23510	COG0673	inositol 2-dehydrogenase activity
BBN63_RS23525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBN63_RS23545	COG2409	Drug exporters of the RND superfamily
BBN63_RS23560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBN63_RS23570	COG3718	enzyme involved in inositol metabolism
BBN63_RS23585	COG4989	oxidoreductase activity
BBN63_RS23600	COG1131	(ABC) transporter
BBN63_RS23625	COG2267	carboxylic ester hydrolase activity
BBN63_RS23695	COG0629	single-stranded DNA binding
BBN63_RS23720	COG1136	(ABC) transporter
BBN63_RS23720	COG0577	efflux transmembrane transporter activity
BBN63_RS23740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BBN63_RS23770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBN63_RS23785	COG1486	melibiose metabolic process
BBN63_RS23790	COG0395	ABC-type sugar transport system, permease component
BBN63_RS23795	COG1175	transmembrane transport
BBN63_RS23805	COG1940	carbohydrate kinase activity
BBN63_RS23810	COG0668	transmembrane transport
BBN63_RS23870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BBN63_RS23875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BBN63_RS23880	COG0584	glycerophosphoryl diester phosphodiesterase
BBN63_RS23890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBN63_RS23895	COG3842	ATPase activity
BBN63_RS23900	COG2378	regulation of single-species biofilm formation
BBN63_RS23905	COG3842	ATPase activity
BBN63_RS23915	COG1175	transmembrane transport
BBN63_RS23920	COG1653	transport
BBN63_RS23930	COG0588	phosphoglycerate mutase activity
BBN63_RS23940	COG1113	amino acid transport
BBN63_RS23965	COG4552	Acetyltransferase involved in intracellular survival and related
BBN63_RS23975	COG0475	glutathione-regulated potassium exporter activity
BBN63_RS23985	COG3594	Acyltransferase
BBN63_RS24010	COG0544	peptidyl-prolyl cis-trans isomerase activity
BBN63_RS24015	COG0740	serine-type endopeptidase activity
BBN63_RS24020	COG0740	serine-type endopeptidase activity
BBN63_RS24025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BBN63_RS24035	COG0525	valine-tRNA ligase activity
BBN63_RS24040	COG0285	dihydrofolate synthase activity
BBN63_RS24050	COG0105	UTP biosynthetic process
BBN63_RS24055	COG1077	Cell shape determining protein MreB Mrl
BBN63_RS24070	COG0768	penicillin binding
BBN63_RS24075	COG0772	Belongs to the SEDS family
BBN63_RS24120	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS24125	COG1309	transcriptional regulator
BBN63_RS24150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBN63_RS24185	COG1530	ribonuclease E activity
BBN63_RS24195	COG0673	inositol 2-dehydrogenase activity
BBN63_RS24235	COG3594	Acyltransferase
BBN63_RS24240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BBN63_RS24245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BBN63_RS24250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BBN63_RS24255	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS24270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BBN63_RS24280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BBN63_RS24295	COG0501	Belongs to the peptidase M48B family
BBN63_RS24305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBN63_RS24315	COG0799	negative regulation of ribosome biogenesis
BBN63_RS24320	COG0588	phosphoglycerate mutase activity
BBN63_RS24335	COG1051	belongs to the nudix hydrolase family
BBN63_RS24350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BBN63_RS24360	COG0495	leucyl-tRNA aminoacylation
BBN63_RS24370	COG1307	EDD domain protein, DegV family
BBN63_RS24375	COG1555	photosystem II stabilization
BBN63_RS24400	COG0268	Binds directly to 16S ribosomal RNA
BBN63_RS24405	COG0481	GTPase activity
BBN63_RS24440	COG1420	regulation of RNA biosynthetic process
BBN63_RS24445	COG0484	heat shock protein binding
BBN63_RS24460	COG0537	adenosine 5'-monophosphoramidase activity
BBN63_RS24465	COG1234	tRNA 3'-trailer cleavage
BBN63_RS24470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBN63_RS24480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BBN63_RS24490	COG2315	Protein conserved in bacteria
BBN63_RS24510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BBN63_RS24520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BBN63_RS24530	COG2409	Drug exporters of the RND superfamily
BBN63_RS24540	COG2197	response regulator
BBN63_RS24545	COG1381	Involved in DNA repair and RecF pathway recombination
BBN63_RS24550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BBN63_RS24560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBN63_RS24565	COG1121	(ABC) transporter
BBN63_RS24570	COG3443	Belongs to the bacterial solute-binding protein 9 family
BBN63_RS24570	COG0803	Belongs to the bacterial solute-binding protein 9 family
BBN63_RS24575	COG0423	glycine-tRNA ligase activity
BBN63_RS24600	COG0477	Major facilitator Superfamily
BBN63_RS24610	COG0574	Belongs to the PEP-utilizing enzyme family
BBN63_RS24610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBN63_RS24625	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS24630	COG1309	transcriptional regulator
BBN63_RS24635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BBN63_RS24635	COG2146	nitrite reductase [NAD(P)H] activity
BBN63_RS24640	COG2146	nitrite reductase [NAD(P)H] activity
BBN63_RS24640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BBN63_RS24645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BBN63_RS24700	COG1802	Transcriptional regulator
BBN63_RS24710	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BBN63_RS24725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBN63_RS24735	COG0243	molybdopterin cofactor binding
BBN63_RS24740	COG2949	membrane
BBN63_RS24750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BBN63_RS24760	COG0358	DNA primase activity
BBN63_RS24765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBN63_RS24780	COG1070	Carbohydrate kinase
BBN63_RS24860	COG1077	Cell shape determining protein MreB Mrl
BBN63_RS24880	COG2130	NADP-dependent
BBN63_RS24885	COG1764	response to oxidative stress
BBN63_RS24905	COG1309	transcriptional regulator
BBN63_RS24935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBN63_RS24940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBN63_RS24945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBN63_RS24960	COG1741	Belongs to the pirin family
BBN63_RS24970	COG0789	Transcriptional regulator
BBN63_RS24975	COG0667	Aldo Keto reductase
BBN63_RS24990	COG2197	response regulator
BBN63_RS24995	COG4585	Histidine kinase
BBN63_RS25015	COG0477	Major facilitator Superfamily
BBN63_RS25030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBN63_RS25035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BBN63_RS25080	COG1358	cellular component organization or biogenesis
BBN63_RS25090	COG0586	Pfam SNARE associated Golgi protein
BBN63_RS25095	COG4585	Histidine kinase
BBN63_RS25100	COG2197	response regulator
BBN63_RS25160	COG2259	Doxx family
BBN63_RS25180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBN63_RS25215	COG1733	regulation of RNA biosynthetic process
BBN63_RS25220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BBN63_RS25245	COG3845	ABC transporter
BBN63_RS25265	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS25310	COG2197	response regulator
BBN63_RS25315	COG4585	Histidine kinase
BBN63_RS25325	COG1131	(ABC) transporter
BBN63_RS25340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBN63_RS25345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBN63_RS25365	COG0800	Aldolase
BBN63_RS25370	COG3022	response to hydroperoxide
BBN63_RS25425	COG0318	PFAM AMP-dependent synthetase and ligase
BBN63_RS25445	COG0604	alcohol dehydrogenase
BBN63_RS25445	COG3321	synthase
BBN63_RS25460	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBN63_RS25465	COG2091	lysine biosynthetic process via aminoadipic acid
BBN63_RS25470	COG3629	intracellular signal transduction
BBN63_RS25470	COG3903	Transcriptional regulator
BBN63_RS25485	COG1013	pyruvate-flavodoxin oxidoreductase activity
BBN63_RS25490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BBN63_RS25490	COG0674	pyruvate-flavodoxin oxidoreductase activity
BBN63_RS25495	COG2197	response regulator
BBN63_RS25500	COG4585	Histidine kinase
BBN63_RS25535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBN63_RS25550	COG1819	glycosyl
BBN63_RS25570	COG0667	Aldo Keto reductase
BBN63_RS25575	COG0384	phenazine biosynthesis protein PhzF
BBN63_RS25580	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS25585	COG3540	Alkaline phosphatase
BBN63_RS25595	COG2814	Major facilitator Superfamily
BBN63_RS25610	COG1834	amidinotransferase
BBN63_RS25630	COG1120	ATPase activity
BBN63_RS25635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS25660	COG5398	heme oxygenase
BBN63_RS25695	COG1994	Peptidase M50
BBN63_RS25725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BBN63_RS25730	COG0477	Major facilitator Superfamily
BBN63_RS25745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBN63_RS25745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BBN63_RS25780	COG0640	Transcriptional regulator
BBN63_RS25785	COG0346	lactoylglutathione lyase activity
BBN63_RS25790	COG0174	glutamine synthetase
BBN63_RS25810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BBN63_RS25820	COG1609	Transcriptional regulator
BBN63_RS25825	COG2182	Extracellular solute-binding protein
BBN63_RS25830	COG1175	transmembrane transport
BBN63_RS25835	COG0395	ABC-type sugar transport system, permease component
BBN63_RS25840	COG0366	Alpha amylase catalytic
BBN63_RS25900	COG2197	response regulator
BBN63_RS25905	COG4585	Histidine kinase
BBN63_RS25925	COG0745	RESPONSE REGULATOR receiver
BBN63_RS25970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BBN63_RS26000	COG1595	DNA-templated transcription, initiation
BBN63_RS26015	COG2197	response regulator
BBN63_RS26040	COG1120	ATPase activity
BBN63_RS26090	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BBN63_RS26105	COG0516	GMP reductase activity
BBN63_RS26105	COG0517	IMP dehydrogenase activity
BBN63_RS26150	COG0105	UTP biosynthetic process
BBN63_RS26160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBN63_RS26195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BBN63_RS26200	COG0321	lipoyl(octanoyl) transferase activity
BBN63_RS26245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BBN63_RS26255	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBN63_RS26260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBN63_RS26265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBN63_RS26275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BBN63_RS26285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BBN63_RS26300	COG1132	(ABC) transporter
BBN63_RS26305	COG2226	methyltransferase
BBN63_RS26330	COG2197	response regulator
BBN63_RS26335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBN63_RS26340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BBN63_RS26360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBN63_RS26370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BBN63_RS26375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BBN63_RS26385	COG1376	ErfK ybiS ycfS ynhG family protein
BBN63_RS26395	COG1845	cytochrome c oxidase, subunit III
BBN63_RS26405	COG0723	plastoquinol--plastocyanin reductase activity
BBN63_RS26410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BBN63_RS26415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBN63_RS26420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBN63_RS26465	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS26485	COG0003	Pfam Anion-transporting ATPase
BBN63_RS26495	COG1940	carbohydrate kinase activity
BBN63_RS26520	COG4585	Histidine kinase
BBN63_RS26525	COG2197	response regulator
BBN63_RS26530	COG0205	6-phosphofructokinase activity
BBN63_RS26540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BBN63_RS26550	COG2193	ferroxidase activity
BBN63_RS26555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BBN63_RS26560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BBN63_RS26565	COG0515	serine threonine protein kinase
BBN63_RS26565	COG2815	serine threonine protein kinase
BBN63_RS26570	COG2815	serine threonine protein kinase
BBN63_RS26570	COG0515	serine threonine protein kinase
BBN63_RS26575	COG2022	thiamine diphosphate biosynthetic process
BBN63_RS26585	COG2022	thiamine diphosphate biosynthetic process
BBN63_RS26585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBN63_RS26600	COG0352	thiamine-phosphate diphosphorylase activity
BBN63_RS26615	COG1233	COG1233 Phytoene dehydrogenase and related
BBN63_RS26625	COG1309	transcriptional regulator
BBN63_RS26635	COG1136	(ABC) transporter
BBN63_RS26645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBN63_RS26665	COG0714	Associated with various cellular activities
BBN63_RS26675	COG0275	rRNA processing
BBN63_RS26690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBN63_RS26700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBN63_RS26705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BBN63_RS26715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BBN63_RS26720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BBN63_RS26740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBN63_RS26745	COG1799	cell septum assembly
BBN63_RS26755	COG3599	regulation of cell shape
BBN63_RS26760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BBN63_RS26770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BBN63_RS26825	COG0587	DNA-directed DNA polymerase activity
BBN63_RS26830	COG1432	Conserved Protein
BBN63_RS26870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BBN63_RS26875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBN63_RS26880	COG0131	Imidazoleglycerol-phosphate dehydratase
BBN63_RS26885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BBN63_RS26890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BBN63_RS26895	COG0251	oxidation-reduction process
BBN63_RS26900	COG0107	imidazoleglycerol-phosphate synthase activity
BBN63_RS26915	COG2508	Transcriptional regulator
BBN63_RS26940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BBN63_RS26965	COG0134	indole-3-glycerol-phosphate synthase activity
BBN63_RS26975	COG0133	tryptophan synthase activity
BBN63_RS26980	COG0159	tryptophan synthase activity
BBN63_RS26990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BBN63_RS26995	COG2301	Belongs to the HpcH HpaI aldolase family
BBN63_RS27000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BBN63_RS27005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBN63_RS27025	COG1397	ADP-ribosylglycohydrolase
BBN63_RS27035	COG0069	glutamate synthase activity
BBN63_RS27035	COG0070	glutamate synthase
BBN63_RS27035	COG0067	glutamate synthase
BBN63_RS27050	COG1278	Cold shock
BBN63_RS27055	COG0513	Belongs to the DEAD box helicase family
BBN63_RS27065	COG2732	(Barnase) inhibitor
BBN63_RS27100	COG1605	Chorismate mutase
BBN63_RS27100	COG0287	Prephenate dehydrogenase
BBN63_RS27115	COG0737	Belongs to the 5'-nucleotidase family
BBN63_RS27175	COG2050	protein possibly involved in aromatic compounds catabolism
BBN63_RS27200	COG1643	Atp-dependent helicase
BBN63_RS27205	COG0596	Alpha beta hydrolase
BBN63_RS27205	COG2226	methyltransferase
BBN63_RS27205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BBN63_RS27220	COG0237	dephospho-CoA kinase activity
BBN63_RS27240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBN63_RS27270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBN63_RS27275	COG2313	pseudouridylate synthase activity
BBN63_RS27280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBN63_RS27285	COG0584	glycerophosphoryl diester phosphodiesterase
BBN63_RS27295	COG0556	nucleotide-excision repair
BBN63_RS27325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBN63_RS27355	COG0322	excinuclease ABC activity
BBN63_RS27360	COG1660	Displays ATPase and GTPase activities
BBN63_RS27365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BBN63_RS27370	COG1481	regulation of sporulation
BBN63_RS27380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBN63_RS27385	COG0126	phosphoglycerate kinase activity
BBN63_RS27390	COG0149	triose-phosphate isomerase activity
BBN63_RS27395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBN63_RS27410	COG0166	Belongs to the GPI family
BBN63_RS27435	COG0714	Associated with various cellular activities
BBN63_RS27450	COG0363	glucosamine-6-phosphate deaminase activity
BBN63_RS27465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBN63_RS27475	COG0109	protoheme IX farnesyltransferase activity
BBN63_RS27490	COG1612	heme a metabolic process
BBN63_RS27520	COG0719	Fe-S assembly protein
BBN63_RS27530	COG0396	ATPase activity
BBN63_RS27535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBN63_RS27540	COG0822	iron-sulfur transferase activity
BBN63_RS27545	COG2151	metal-sulfur cluster biosynthetic enzyme
BBN63_RS27555	COG2076	Multidrug Resistance protein
BBN63_RS27560	COG3226	Transcriptional regulator
BBN63_RS27580	COG2171	N-acyltransferase activity
BBN63_RS27615	COG0515	serine threonine protein kinase
BBN63_RS27615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBN63_RS27640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBN63_RS27645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBN63_RS27660	COG0768	penicillin binding
BBN63_RS27665	COG2197	response regulator
BBN63_RS27670	COG4585	Histidine kinase
BBN63_RS27705	COG5285	phytanoyl-CoA dioxygenase
BBN63_RS27710	COG1917	Cupin 2, conserved barrel domain protein
BBN63_RS27785	COG1797	cobyrinic acid a,c-diamide synthase activity
BBN63_RS27790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BBN63_RS27805	COG1492	cobalamin metabolic process
BBN63_RS27810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BBN63_RS27825	COG0235	Class ii aldolase
BBN63_RS27845	COG0488	(ABC) transporter
BBN63_RS27860	COG5297	Belongs to the glycosyl hydrolase family 6
BBN63_RS27910	COG3387	PFAM Glycoside hydrolase 15-related
BBN63_RS27925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBN63_RS27950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBN63_RS27955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BBN63_RS27975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBN63_RS27990	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS27995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBN63_RS28005	COG2186	Transcriptional regulator
BBN63_RS28025	COG0560	Phosphoserine phosphatase
BBN63_RS28025	COG3830	Belongs to the UPF0237 family
BBN63_RS28030	COG1716	ATPase activity
BBN63_RS28030	COG0842	Transport permease protein
BBN63_RS28030	COG1131	(ABC) transporter
BBN63_RS28050	COG4585	Histidine kinase
BBN63_RS28055	COG2197	response regulator
BBN63_RS28070	COG1119	ATPase activity
BBN63_RS28095	COG1881	PFAM PEBP family protein
BBN63_RS28105	COG2094	Belongs to the DNA glycosylase MPG family
BBN63_RS28140	COG0647	UMP catabolic process
BBN63_RS28150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS28155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBN63_RS28160	COG1120	ATPase activity
BBN63_RS28180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BBN63_RS28185	COG0497	DNA recombination
BBN63_RS28190	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS28200	COG3387	PFAM Glycoside hydrolase 15-related
BBN63_RS28205	COG0504	CTP synthase activity
BBN63_RS28210	COG0494	nUDIX hydrolase
BBN63_RS28220	COG0686	Belongs to the AlaDH PNT family
BBN63_RS28235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BBN63_RS28240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BBN63_RS28245	COG1187	pseudouridine synthase activity
BBN63_RS28250	COG3201	nicotinamide mononucleotide transporter
BBN63_RS28270	COG3541	Predicted nucleotidyltransferase
BBN63_RS28290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BBN63_RS28300	COG1160	GTP binding
BBN63_RS28315	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS28335	COG0671	phosphoesterase, PA-phosphatase related
BBN63_RS28340	COG0477	Major facilitator Superfamily
BBN63_RS28345	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS28350	COG1799	cell septum assembly
BBN63_RS28375	COG0587	DNA-directed DNA polymerase activity
BBN63_RS28400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BBN63_RS28405	COG0395	ABC-type sugar transport system, permease component
BBN63_RS28410	COG1175	transmembrane transport
BBN63_RS28415	COG2182	Extracellular solute-binding protein
BBN63_RS28420	COG2188	Transcriptional regulator
BBN63_RS28425	COG4565	transcriptional regulatory protein
BBN63_RS28445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBN63_RS28455	COG0456	acetyltransferase
BBN63_RS28460	COG1725	Transcriptional regulator
BBN63_RS28465	COG0842	Transport permease protein
BBN63_RS28485	COG1649	PFAM Uncharacterised BCR, COG1649
BBN63_RS28485	COG0726	polysaccharide deacetylase
BBN63_RS28490	COG1216	Glycosyl transferase, family 2
BBN63_RS28500	COG2755	lipolytic protein G-D-S-L family
BBN63_RS28535	COG2188	Transcriptional regulator
BBN63_RS28540	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BBN63_RS28545	COG0243	molybdopterin cofactor binding
BBN63_RS28550	COG2851	Citrate transporter
BBN63_RS28600	COG0789	Transcriptional regulator
BBN63_RS28625	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS28650	COG2149	membrane
BBN63_RS28655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BBN63_RS28660	COG3573	Dehydrogenase
BBN63_RS28670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BBN63_RS28685	COG3265	gluconokinase activity
BBN63_RS28690	COG2186	Transcriptional regulator
BBN63_RS28700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBN63_RS28710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBN63_RS28735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBN63_RS28740	COG0667	Aldo Keto reductase
BBN63_RS28745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBN63_RS28755	COG0598	Magnesium transport protein CorA
BBN63_RS28775	COG0215	cysteine-tRNA ligase activity
BBN63_RS28785	COG4948	Mandelate Racemase Muconate Lactonizing
BBN63_RS28790	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS28800	COG1129	ABC transporter
BBN63_RS28805	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS28810	COG2186	Transcriptional regulator
BBN63_RS28815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BBN63_RS28820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BBN63_RS28825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBN63_RS28830	COG1414	Transcriptional regulator
BBN63_RS28835	COG0646	methionine synthase
BBN63_RS28835	COG1410	methionine synthase
BBN63_RS28845	COG0747	negative chemotaxis
BBN63_RS28850	COG2197	response regulator
BBN63_RS28860	COG1994	Peptidase M50
BBN63_RS28860	COG0517	IMP dehydrogenase activity
BBN63_RS28885	COG1222	aaa ATPase
BBN63_RS28890	COG4122	O-methyltransferase activity
BBN63_RS28905	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BBN63_RS28910	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BBN63_RS28915	COG1609	Transcriptional regulator
BBN63_RS28925	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BBN63_RS28960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBN63_RS28965	COG0805	protein transport
BBN63_RS28985	COG1397	ADP-ribosylglycohydrolase
BBN63_RS29010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBN63_RS29015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBN63_RS29030	COG1595	DNA-templated transcription, initiation
BBN63_RS29055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBN63_RS29060	COG0517	IMP dehydrogenase activity
BBN63_RS29060	COG4175	Glycine betaine
BBN63_RS29065	COG4176	ABC-type proline glycine betaine transport system permease component
BBN63_RS29095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BBN63_RS29100	COG1113	amino acid transport
BBN63_RS29105	COG2186	Transcriptional regulator
BBN63_RS29110	COG0174	glutamine synthetase
BBN63_RS29115	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS29165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BBN63_RS29170	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBN63_RS29180	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS29190	COG0318	PFAM AMP-dependent synthetase and ligase
BBN63_RS29195	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS29230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBN63_RS29245	COG2124	cytochrome p450
BBN63_RS29255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BBN63_RS29265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BBN63_RS29270	COG2091	lysine biosynthetic process via aminoadipic acid
BBN63_RS29275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBN63_RS29280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BBN63_RS29285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BBN63_RS29290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBN63_RS29295	COG5002	protein histidine kinase activity
BBN63_RS29300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BBN63_RS29305	COG0072	phenylalanine-tRNA ligase activity
BBN63_RS29305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBN63_RS29325	COG1649	PFAM Uncharacterised BCR, COG1649
BBN63_RS29330	COG0697	spore germination
BBN63_RS29355	COG4941	Belongs to the sigma-70 factor family
BBN63_RS29395	COG2050	protein possibly involved in aromatic compounds catabolism
BBN63_RS29400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BBN63_RS29405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BBN63_RS29410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BBN63_RS29415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBN63_RS29420	COG1438	arginine binding
BBN63_RS29440	COG0137	argininosuccinate synthase activity
BBN63_RS29445	COG0165	Argininosuccinate lyase
BBN63_RS29460	COG0477	Major facilitator Superfamily
BBN63_RS29465	COG0204	Acyl-transferase
BBN63_RS29465	COG0318	PFAM AMP-dependent synthetase and ligase
BBN63_RS29495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBN63_RS29500	COG2011	ABC-type metal ion transport system permease component
BBN63_RS29505	COG1464	Belongs to the NlpA lipoprotein family
BBN63_RS29520	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BBN63_RS29525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BBN63_RS29525	COG1648	precorrin-2 dehydrogenase activity
BBN63_RS29585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBN63_RS29595	COG0456	acetyltransferase
BBN63_RS29650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BBN63_RS29655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBN63_RS29675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBN63_RS29680	COG1560	Kdo2-lipid A biosynthetic process
BBN63_RS29685	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS29695	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BBN63_RS29700	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BBN63_RS29705	COG0217	transcriptional regulatory protein
BBN63_RS29710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BBN63_RS29715	COG0632	four-way junction helicase activity
BBN63_RS29720	COG2255	four-way junction helicase activity
BBN63_RS29730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBN63_RS29735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBN63_RS29740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BBN63_RS29745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBN63_RS29750	COG1196	nuclear chromosome segregation
BBN63_RS29765	COG0124	histidyl-tRNA synthetase
BBN63_RS29785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BBN63_RS29805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BBN63_RS29810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BBN63_RS29815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BBN63_RS29820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBN63_RS29825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BBN63_RS29830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BBN63_RS29835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BBN63_RS29840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBN63_RS29850	COG0006	proline dipeptidase activity
BBN63_RS29855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBN63_RS29860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBN63_RS29870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BBN63_RS29875	COG0540	Belongs to the ATCase OTCase family
BBN63_RS29880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBN63_RS29890	COG0505	Belongs to the CarA family
BBN63_RS29895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BBN63_RS29900	COG0167	dihydroorotate dehydrogenase activity
BBN63_RS29905	COG0284	orotidine-5'-phosphate decarboxylase activity
BBN63_RS29920	COG1758	RNA polymerase activity
BBN63_RS29930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BBN63_RS29945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BBN63_RS29975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBN63_RS29980	COG2390	Transcriptional regulator
BBN63_RS29990	COG1191	sigma factor activity
BBN63_RS30015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBN63_RS30030	COG2233	PERMEase
BBN63_RS30035	COG0738	Major facilitator superfamily
BBN63_RS30040	COG1846	Transcriptional regulator
BBN63_RS30040	COG1940	carbohydrate kinase activity
BBN63_RS30060	COG3655	Transcriptional regulator
BBN63_RS30115	COG3201	nicotinamide mononucleotide transporter
BBN63_RS30120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBN63_RS30120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBN63_RS30125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BBN63_RS30130	COG0140	phosphoribosyl-ATP diphosphatase activity
BBN63_RS30135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BBN63_RS30180	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS30200	COG1216	Glycosyl transferase, family 2
BBN63_RS30205	COG3030	protein affecting phage T7 exclusion by the F plasmid
BBN63_RS30215	COG2270	Major facilitator Superfamily
BBN63_RS30255	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS30260	COG0438	transferase activity, transferring glycosyl groups
BBN63_RS30300	COG2018	Roadblock/LC7 domain
BBN63_RS30320	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BBN63_RS30335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBN63_RS30345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBN63_RS30380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BBN63_RS30400	COG1716	ATPase activity
BBN63_RS30420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBN63_RS30430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBN63_RS30430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBN63_RS30500	COG0697	spore germination
BBN63_RS30525	COG0142	geranyltranstransferase activity
BBN63_RS30540	COG3507	Belongs to the glycosyl hydrolase 43 family
BBN63_RS30550	COG0395	ABC-type sugar transport system, permease component
BBN63_RS30565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBN63_RS30570	COG1802	Transcriptional regulator
BBN63_RS30575	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS30600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBN63_RS30605	COG1408	metallophosphoesterase
BBN63_RS30610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBN63_RS30615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BBN63_RS30625	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBN63_RS30625	COG0022	dehydrogenase e1 component
BBN63_RS30645	COG3629	intracellular signal transduction
BBN63_RS30645	COG3903	Transcriptional regulator
BBN63_RS30680	COG0318	PFAM AMP-dependent synthetase and ligase
BBN63_RS30710	COG0477	Major facilitator Superfamily
BBN63_RS30730	COG0477	Major facilitator Superfamily
BBN63_RS30735	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS30755	COG1309	transcriptional regulator
BBN63_RS30760	COG0366	Alpha amylase catalytic
BBN63_RS30765	COG2409	Drug exporters of the RND superfamily
BBN63_RS30795	COG0747	negative chemotaxis
BBN63_RS30800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BBN63_RS30820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BBN63_RS30830	COG1968	undecaprenyl-diphosphatase activity
BBN63_RS30850	COG1024	Enoyl-CoA hydratase
BBN63_RS30865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBN63_RS30895	COG2124	cytochrome p450
BBN63_RS30945	COG1832	CoA-binding protein
BBN63_RS30950	COG1739	Uncharacterized protein family UPF0029
BBN63_RS30955	COG0420	3'-5' exonuclease activity
BBN63_RS30960	COG0419	ATPase involved in DNA repair
BBN63_RS30965	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS30970	COG1522	sequence-specific DNA binding
BBN63_RS30990	COG0626	cystathionine gamma-synthase activity
BBN63_RS31005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBN63_RS31015	COG2188	Transcriptional regulator
BBN63_RS31020	COG1940	carbohydrate kinase activity
BBN63_RS31035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBN63_RS31055	COG1280	lysine exporter protein (LysE YggA)
BBN63_RS31070	COG0631	protein serine/threonine phosphatase activity
BBN63_RS31085	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BBN63_RS31090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BBN63_RS31095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BBN63_RS31120	COG0740	serine-type endopeptidase activity
BBN63_RS31130	COG0831	urea catabolic process
BBN63_RS31135	COG0832	Belongs to the urease beta subunit family
BBN63_RS31140	COG0804	urea catabolic process
BBN63_RS31145	COG0830	nickel cation binding
BBN63_RS31150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BBN63_RS31155	COG0829	nickel cation binding
BBN63_RS31165	COG0204	Acyl-transferase
BBN63_RS31195	COG2268	Band 7 protein
BBN63_RS31220	COG0205	6-phosphofructokinase activity
BBN63_RS31225	COG3442	glutamine amidotransferase
BBN63_RS31235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BBN63_RS31245	COG0395	ABC-type sugar transport system, permease component
BBN63_RS31250	COG1175	transmembrane transport
BBN63_RS31255	COG2182	Extracellular solute-binding protein
BBN63_RS31265	COG0242	peptide deformylase activity
BBN63_RS31275	COG1960	acyl-CoA dehydrogenase activity
BBN63_RS31285	COG0386	Belongs to the glutathione peroxidase family
BBN63_RS31290	COG1946	Acyl-CoA thioesterase
BBN63_RS31305	COG1132	(ABC) transporter
BBN63_RS31310	COG1132	(ABC) transporter
BBN63_RS31325	COG1132	(ABC) transporter
BBN63_RS31335	COG2072	flavoprotein involved in K transport
BBN63_RS31345	COG4977	sequence-specific DNA binding
BBN63_RS31390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBN63_RS31430	COG0375	protein maturation
BBN63_RS31445	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BBN63_RS31475	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BBN63_RS31480	COG0298	carbon dioxide binding
BBN63_RS31490	COG0309	Hydrogenase expression formation protein (HypE)
BBN63_RS31500	COG2367	Beta-lactamase
BBN63_RS31505	COG0583	DNA-binding transcription factor activity
BBN63_RS31585	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS31605	COG1376	ErfK ybiS ycfS ynhG family protein
BBN63_RS31620	COG0745	RESPONSE REGULATOR receiver
BBN63_RS31625	COG2205	protein histidine kinase activity
BBN63_RS31650	COG0129	dihydroxy-acid dehydratase activity
BBN63_RS31660	COG1278	Cold shock
BBN63_RS31665	COG0672	)-iron permease
BBN63_RS31670	COG2837	iron assimilation
BBN63_RS31690	COG0640	Transcriptional regulator
BBN63_RS31700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBN63_RS31715	COG4221	oxidoreductase activity
BBN63_RS31735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BBN63_RS31740	COG0667	Aldo Keto reductase
BBN63_RS31765	COG1309	transcriptional regulator
BBN63_RS31780	COG0671	phosphoesterase, PA-phosphatase related
BBN63_RS31810	COG0673	inositol 2-dehydrogenase activity
BBN63_RS31820	COG4948	Mandelate Racemase Muconate Lactonizing
BBN63_RS31825	COG1414	Transcriptional regulator
BBN63_RS31840	COG3833	ABC-type maltose transport systems, permease component
BBN63_RS31845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBN63_RS31855	COG0584	glycerophosphoryl diester phosphodiesterase
BBN63_RS31880	COG0204	Acyl-transferase
BBN63_RS31900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BBN63_RS31925	COG1660	Displays ATPase and GTPase activities
BBN63_RS31930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBN63_RS31940	COG0445	tRNA wobble uridine modification
BBN63_RS31955	COG4585	Histidine kinase
BBN63_RS31960	COG2197	response regulator
BBN63_RS31970	COG0738	Major facilitator superfamily
BBN63_RS31975	COG1940	carbohydrate kinase activity
BBN63_RS31990	COG1136	(ABC) transporter
BBN63_RS31990	COG0577	efflux transmembrane transporter activity
BBN63_RS31995	COG0577	efflux transmembrane transporter activity
BBN63_RS32025	COG1349	DNA-binding transcription factor activity
BBN63_RS32035	COG0464	growth
BBN63_RS32065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BBN63_RS32135	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS32140	COG1129	ABC transporter
BBN63_RS32145	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBN63_RS32150	COG1879	ABC-type sugar transport system periplasmic component
BBN63_RS32170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BBN63_RS32220	COG2197	response regulator
BBN63_RS32245	COG0475	glutathione-regulated potassium exporter activity
BBN63_RS32275	COG1695	Transcriptional regulator
BBN63_RS32280	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBN63_RS32280	COG1902	pentaerythritol trinitrate reductase activity
BBN63_RS32290	COG1461	Dihydroxyacetone kinase
BBN63_RS32295	COG2376	Dihydroxyacetone kinase
BBN63_RS32335	COG3290	protein histidine kinase activity
BBN63_RS32360	COG1857	crispr-associated protein
BBN63_RS32375	COG1518	maintenance of DNA repeat elements
BBN63_RS32380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBN63_RS32510	COG0346	lactoylglutathione lyase activity
BBN63_RS32515	COG0667	Aldo Keto reductase
BBN63_RS32520	COG1408	metallophosphoesterase
BBN63_RS32555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBN63_RS32575	COG3608	succinylglutamate desuccinylase aspartoacylase
BBN63_RS32575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BBN63_RS32580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BBN63_RS32585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BBN63_RS32590	COG2080	2 iron, 2 sulfur cluster binding
BBN63_RS32600	COG0656	L-ascorbic acid biosynthetic process
BBN63_RS32640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBN63_RS32655	COG1064	alcohol dehydrogenase
BBN63_RS32670	COG3547	Transposase (IS116 IS110 IS902 family)
BBN63_RS32695	COG0588	phosphoglycerate mutase activity
BBN63_RS32715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BBN63_RS32725	COG1454	alcohol dehydrogenase
BBN63_RS32735	COG0318	PFAM AMP-dependent synthetase and ligase
BBN63_RS32770	COG0477	Major facilitator Superfamily
BBN63_RS32790	COG1064	alcohol dehydrogenase
BBN63_RS32965	COG0714	Associated with various cellular activities
BBN63_RS33020	COG2885	chlorophyll binding
BBN63_RS33020	COG3047	cAMP biosynthetic process
BBN63_RS33170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BBN63_RS33215	COG0667	Aldo Keto reductase
BBN63_RS33260	COG1408	metallophosphoesterase
BBN63_RS33280	COG4221	oxidoreductase activity
BBN63_RS33285	COG0667	Aldo Keto reductase
BBN63_RS33290	COG0667	Aldo Keto reductase
BBN63_RS33300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBN63_RS33315	COG0778	Nitroreductase
BBN63_RS33325	COG1902	pentaerythritol trinitrate reductase activity
BBN63_RS33335	COG4221	oxidoreductase activity
BBN63_RS33350	COG0515	serine threonine protein kinase
BBN63_RS33350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBN63_RS33405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBN63_RS33530	COG2124	cytochrome p450
BBN63_RS33590	COG2301	Belongs to the HpcH HpaI aldolase family
BBN63_RS33600	COG4569	acetaldehyde dehydrogenase (acetylating) activity
BBN63_RS33605	COG3971	2-oxopent-4-enoate hydratase activity
BBN63_RS33615	COG2175	clavaminate synthase activity
BBN63_RS33640	COG2172	sigma factor antagonist activity
BBN63_RS33650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BBN63_RS33655	COG2409	Drug exporters of the RND superfamily
BBN63_RS33675	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS33690	COG1012	belongs to the aldehyde dehydrogenase family
BBN63_RS33705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBN63_RS33710	COG3239	Fatty acid desaturase
BBN63_RS33730	COG4106	trans-aconitate 2-methyltransferase activity
BBN63_RS33750	COG2018	Roadblock/LC7 domain
BBN63_RS33790	COG2304	oxidoreductase activity
BBN63_RS33800	COG2814	Major facilitator Superfamily
BBN63_RS33825	COG2124	cytochrome p450
BBN63_RS33855	COG0588	phosphoglycerate mutase activity
BBN63_RS33860	COG2186	Transcriptional regulator
BBN63_RS33870	COG0318	PFAM AMP-dependent synthetase and ligase
BBN63_RS33875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BBN63_RS33875	COG0825	malonyl-CoA metabolic process
BBN63_RS33885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBN63_RS33895	COG0702	epimerase
BBN63_RS33905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBN63_RS33910	COG2205	protein histidine kinase activity
BBN63_RS33915	COG0745	RESPONSE REGULATOR receiver
BBN63_RS33930	COG0789	Transcriptional regulator
BBN63_RS33975	COG1175	transmembrane transport
BBN63_RS33980	COG0395	ABC-type sugar transport system, permease component
BBN63_RS33990	COG0366	Alpha amylase catalytic
BBN63_RS34000	COG0435	Glutathione S-transferase
BBN63_RS34010	COG1595	DNA-templated transcription, initiation
BBN63_RS34015	COG1309	transcriptional regulator
BBN63_RS34040	COG0588	phosphoglycerate mutase activity
BBN63_RS34045	COG0604	alcohol dehydrogenase
BBN63_RS34045	COG3321	synthase
BBN63_RS34045	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS34065	COG0395	ABC-type sugar transport system, permease component
BBN63_RS34085	COG1011	Hydrolase
BBN63_RS34090	COG2813	Specifically methylates the guanine in position
BBN63_RS34135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBN63_RS34140	COG0596	Alpha beta hydrolase
BBN63_RS34165	COG3540	Alkaline phosphatase
BBN63_RS34170	COG1472	Belongs to the glycosyl hydrolase 3 family
BBN63_RS34175	COG3833	ABC-type maltose transport systems, permease component
BBN63_RS34180	COG1175	transmembrane transport
BBN63_RS34190	COG1609	Transcriptional regulator
BBN63_RS34195	COG1252	NADH dehydrogenase
BBN63_RS34205	COG3250	beta-galactosidase activity
BBN63_RS34210	COG0745	RESPONSE REGULATOR receiver
BBN63_RS34215	COG4251	negative regulation of phosphorylation
BBN63_RS34220	COG0784	Response regulator, receiver
BBN63_RS34235	COG1191	sigma factor activity
BBN63_RS34250	COG0702	epimerase
BBN63_RS34255	COG1874	Beta-galactosidase
BBN63_RS34255	COG0366	Alpha amylase catalytic
BBN63_RS34270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBN63_RS34330	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BBN63_RS34335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBN63_RS34335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBN63_RS34365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BBN63_RS34375	COG4989	oxidoreductase activity
BBN63_RS34405	COG0254	rRNA binding
BBN63_RS34425	COG0477	Major facilitator Superfamily
BBN63_RS34430	COG0698	ribose 5-phosphate isomerase
BBN63_RS34435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBN63_RS34440	COG1609	Transcriptional regulator
BBN63_RS34445	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS34450	COG0697	spore germination
BBN63_RS34485	COG1902	pentaerythritol trinitrate reductase activity
BBN63_RS34495	COG2706	6-phosphogluconolactonase activity
BBN63_RS34510	COG1595	DNA-templated transcription, initiation
BBN63_RS34515	COG3548	integral membrane protein
BBN63_RS34540	COG0395	ABC-type sugar transport system, permease component
BBN63_RS34545	COG1175	transmembrane transport
BBN63_RS34590	COG0656	L-ascorbic acid biosynthetic process
BBN63_RS34615	COG0483	inositol monophosphate 1-phosphatase activity
BBN63_RS34645	COG2770	Histidine kinase
BBN63_RS34645	COG2208	phosphoserine phosphatase activity
BBN63_RS34660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBN63_RS34690	COG1028	Short-chain dehydrogenase reductase Sdr
BBN63_RS34705	COG0667	Aldo Keto reductase
BBN63_RS34710	COG4608	Belongs to the ABC transporter superfamily
BBN63_RS34715	COG0444	Belongs to the ABC transporter superfamily
BBN63_RS34720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBN63_RS34725	COG0601	transmembrane transport
BBN63_RS34730	COG0747	negative chemotaxis
BBN63_RS34735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BBN63_RS34740	COG1349	DNA-binding transcription factor activity
BBN63_RS34745	COG1609	Transcriptional regulator
BBN63_RS34750	COG4209	transmembrane transport
BBN63_RS34755	COG0395	ABC-type sugar transport system, permease component
BBN63_RS34770	COG5297	Belongs to the glycosyl hydrolase family 6
BBN63_RS34790	COG5650	phosphatidylinositol metabolic process
BBN63_RS34800	COG0657	acetylesterase activity
BBN63_RS34815	COG0300	oxidoreductase activity
BBN63_RS34850	COG2770	Histidine kinase
BBN63_RS34850	COG2208	phosphoserine phosphatase activity
BBN63_RS34950	COG2319	Wd-40 repeat
BBN63_RS34950	COG4249	Peptidase C14 caspase catalytic subunit p20
BBN63_RS35060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BBN63_RS35065	COG3876	Protein conserved in bacteria
BBN63_RS35070	COG1472	Belongs to the glycosyl hydrolase 3 family
BBN63_RS35120	COG0515	serine threonine protein kinase
BBN63_RS35120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBN63_RS35125	COG2801	Transposase and inactivated derivatives
BBN63_RS35125	COG3415	Transposase
BBN63_RS35130	COG2318	DinB family
BBN63_RS35180	COG4977	sequence-specific DNA binding