locus-tag	class	description
CP978_RS00005	COG0300	oxidoreductase activity
CP978_RS00020	COG3387	PFAM Glycoside hydrolase 15-related
CP978_RS00040	COG0673	inositol 2-dehydrogenase activity
CP978_RS00055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP978_RS00060	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CP978_RS00075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP978_RS00080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP978_RS00140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP978_RS00170	COG0395	ABC-type sugar transport system, permease component
CP978_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS00325	COG1309	transcriptional regulator
CP978_RS00330	COG0667	Aldo Keto reductase
CP978_RS00450	COG1733	regulation of RNA biosynthetic process
CP978_RS00605	COG1857	crispr-associated protein
CP978_RS00640	COG2205	protein histidine kinase activity
CP978_RS00650	COG1136	(ABC) transporter
CP978_RS00720	COG2208	phosphoserine phosphatase activity
CP978_RS00720	COG2770	Histidine kinase
CP978_RS00795	COG0300	oxidoreductase activity
CP978_RS00840	COG1802	Transcriptional regulator
CP978_RS00865	COG0596	Alpha beta hydrolase
CP978_RS00870	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS00880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS00885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CP978_RS00905	COG1522	sequence-specific DNA binding
CP978_RS00915	COG1177	transmembrane transport
CP978_RS00920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CP978_RS00925	COG3842	ATPase activity
CP978_RS00930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP978_RS00935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CP978_RS00950	COG1917	Cupin 2, conserved barrel domain protein
CP978_RS00950	COG2207	Transcriptional regulator
CP978_RS00965	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
CP978_RS00975	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS00980	COG0477	Major facilitator Superfamily
CP978_RS00985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CP978_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS00995	COG0277	FAD linked oxidase domain protein
CP978_RS01000	COG1070	Carbohydrate kinase
CP978_RS01040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CP978_RS01110	COG4555	ABC transporter
CP978_RS01140	COG1358	cellular component organization or biogenesis
CP978_RS01175	COG0406	alpha-ribazole phosphatase activity
CP978_RS01200	COG1595	DNA-templated transcription, initiation
CP978_RS01210	COG2207	Transcriptional regulator
CP978_RS01305	COG2197	response regulator
CP978_RS01310	COG4585	Histidine kinase
CP978_RS01360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP978_RS01375	COG1802	Transcriptional regulator
CP978_RS01410	COG2159	amidohydrolase
CP978_RS01425	COG1116	anion transmembrane transporter activity
CP978_RS01435	COG0823	Involved in the tonB-independent uptake of proteins
CP978_RS01440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP978_RS01450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CP978_RS01455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP978_RS01475	COG1129	ABC transporter
CP978_RS01480	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP978_RS01490	COG0583	DNA-binding transcription factor activity
CP978_RS01515	COG2267	carboxylic ester hydrolase activity
CP978_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS01540	COG0579	oxidoreductase
CP978_RS01550	COG3962	Belongs to the TPP enzyme family
CP978_RS01635	COG1309	transcriptional regulator
CP978_RS01650	COG0667	Aldo Keto reductase
CP978_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS01720	COG1309	transcriptional regulator
CP978_RS01725	COG2801	Transposase and inactivated derivatives
CP978_RS01745	COG1140	nitrate reductase beta subunit
CP978_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS01815	COG0583	DNA-binding transcription factor activity
CP978_RS01825	COG1733	regulation of RNA biosynthetic process
CP978_RS01830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CP978_RS01880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP978_RS01905	COG2814	Major facilitator Superfamily
CP978_RS01940	COG2837	iron assimilation
CP978_RS01995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP978_RS02000	COG4171	peptide transport system, permease
CP978_RS02010	COG4166	transmembrane transport
CP978_RS02025	COG0019	diaminopimelate decarboxylase activity
CP978_RS02030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP978_RS02035	COG0534	Mate efflux family protein
CP978_RS02070	COG1280	lysine exporter protein (LysE YggA)
CP978_RS02080	COG1396	sequence-specific DNA binding
CP978_RS02160	COG3896	Chloramphenicol phosphotransferase-like protein
CP978_RS02190	COG0800	Aldolase
CP978_RS02200	COG4948	Mandelate Racemase Muconate Lactonizing
CP978_RS02205	COG2186	Transcriptional regulator
CP978_RS02220	COG0395	ABC-type sugar transport system, permease component
CP978_RS02225	COG1175	transmembrane transport
CP978_RS02235	COG3345	alpha-galactosidase
CP978_RS02245	COG0596	Alpha beta hydrolase
CP978_RS02280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP978_RS02285	COG0395	ABC-type sugar transport system, permease component
CP978_RS02290	COG1175	transmembrane transport
CP978_RS02295	COG2182	Extracellular solute-binding protein
CP978_RS02300	COG2188	Transcriptional regulator
CP978_RS02310	COG0697	spore germination
CP978_RS02320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP978_RS02375	COG0142	geranyltranstransferase activity
CP978_RS02395	COG2175	clavaminate synthase activity
CP978_RS02405	COG4521	taurine ABC transporter
CP978_RS02410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP978_RS02440	COG1309	transcriptional regulator
CP978_RS02450	COG0702	epimerase
CP978_RS02485	COG0747	negative chemotaxis
CP978_RS02490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS02515	COG0596	Alpha beta hydrolase
CP978_RS02525	COG0577	efflux transmembrane transporter activity
CP978_RS02530	COG4585	Histidine kinase
CP978_RS02535	COG2197	response regulator
CP978_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS02560	COG0318	PFAM AMP-dependent synthetase and ligase
CP978_RS02575	COG0714	Associated with various cellular activities
CP978_RS02600	COG2072	flavoprotein involved in K transport
CP978_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS02650	COG3647	Membrane
CP978_RS02655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP978_RS02660	COG0765	amino acid transport
CP978_RS02710	COG1902	pentaerythritol trinitrate reductase activity
CP978_RS02710	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP978_RS02720	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS02750	COG3629	intracellular signal transduction
CP978_RS02750	COG3903	Transcriptional regulator
CP978_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS02800	COG4139	cobalamin transport
CP978_RS02805	COG1120	ATPase activity
CP978_RS02815	COG3537	Alpha-1,2-mannosidase
CP978_RS02825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP978_RS02830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS02835	COG1120	ATPase activity
CP978_RS02845	COG0596	Alpha beta hydrolase
CP978_RS02855	COG2226	methyltransferase
CP978_RS02860	COG2318	DinB family
CP978_RS02865	COG2267	carboxylic ester hydrolase activity
CP978_RS02905	COG1335	isochorismatase
CP978_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS02950	COG1846	Transcriptional regulator
CP978_RS02955	COG1764	response to oxidative stress
CP978_RS02965	COG1113	amino acid transport
CP978_RS02980	COG0604	alcohol dehydrogenase
CP978_RS02980	COG3321	synthase
CP978_RS02990	COG0604	alcohol dehydrogenase
CP978_RS02990	COG3321	synthase
CP978_RS02995	COG3321	synthase
CP978_RS02995	COG0604	alcohol dehydrogenase
CP978_RS03030	COG3321	synthase
CP978_RS03030	COG0604	alcohol dehydrogenase
CP978_RS03040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP978_RS03065	COG2318	DinB family
CP978_RS03080	COG0604	alcohol dehydrogenase
CP978_RS03080	COG3321	synthase
CP978_RS03105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CP978_RS03115	COG0183	Belongs to the thiolase family
CP978_RS03120	COG0583	DNA-binding transcription factor activity
CP978_RS03165	COG3253	May function as heme-dependent peroxidase
CP978_RS03230	COG1301	dicarboxylic acid transport
CP978_RS03265	COG3962	Belongs to the TPP enzyme family
CP978_RS03270	COG3718	enzyme involved in inositol metabolism
CP978_RS03285	COG0363	glucosamine-6-phosphate deaminase activity
CP978_RS03305	COG1082	Xylose isomerase domain protein TIM barrel
CP978_RS03315	COG2186	Transcriptional regulator
CP978_RS03320	COG1940	carbohydrate kinase activity
CP978_RS03330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP978_RS03350	COG2318	DinB family
CP978_RS03380	COG4977	sequence-specific DNA binding
CP978_RS03390	COG0077	Prephenate dehydratase
CP978_RS03420	COG2124	cytochrome p450
CP978_RS03430	COG0431	NADPH-dependent FMN reductase
CP978_RS03435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS03440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS03445	COG1126	abc transporter atp-binding protein
CP978_RS03450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP978_RS03455	COG0765	amino acid transport
CP978_RS03535	COG0148	phosphopyruvate hydratase activity
CP978_RS03625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP978_RS03630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP978_RS03635	COG2188	Transcriptional regulator
CP978_RS03645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP978_RS03650	COG1960	acyl-CoA dehydrogenase activity
CP978_RS03680	COG0671	phosphoesterase, PA-phosphatase related
CP978_RS03720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS03725	COG0601	transmembrane transport
CP978_RS03730	COG0747	negative chemotaxis
CP978_RS03740	COG0110	maltose O-acetyltransferase activity
CP978_RS03810	COG0772	Belongs to the SEDS family
CP978_RS03815	COG2353	YceI-like domain
CP978_RS03860	COG1120	ATPase activity
CP978_RS03865	COG1725	Transcriptional regulator
CP978_RS03915	COG1597	lipid kinase activity
CP978_RS03920	COG0667	Aldo Keto reductase
CP978_RS03960	COG0583	DNA-binding transcription factor activity
CP978_RS03975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP978_RS03980	COG2755	lipolytic protein G-D-S-L family
CP978_RS03985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP978_RS04000	COG0586	Pfam SNARE associated Golgi protein
CP978_RS04030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP978_RS04055	COG4221	oxidoreductase activity
CP978_RS04065	COG0726	polysaccharide deacetylase
CP978_RS04080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP978_RS04085	COG0583	DNA-binding transcription factor activity
CP978_RS04090	COG2271	Major facilitator Superfamily
CP978_RS04095	COG1335	isochorismatase
CP978_RS04180	COG3866	Pectate lyase
CP978_RS04200	COG0673	inositol 2-dehydrogenase activity
CP978_RS04215	COG0477	Major facilitator Superfamily
CP978_RS04225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CP978_RS04230	COG1070	Carbohydrate kinase
CP978_RS04245	COG0328	RNA-DNA hybrid ribonuclease activity
CP978_RS04255	COG0561	phosphatase activity
CP978_RS04265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP978_RS04270	COG0443	Heat shock 70 kDa protein
CP978_RS04295	COG2205	protein histidine kinase activity
CP978_RS04305	COG1472	Belongs to the glycosyl hydrolase 3 family
CP978_RS04315	COG1175	transmembrane transport
CP978_RS04320	COG1653	transport
CP978_RS04325	COG1609	Transcriptional regulator
CP978_RS04345	COG0596	Alpha beta hydrolase
CP978_RS04360	COG2124	cytochrome p450
CP978_RS04370	COG0435	Glutathione S-transferase
CP978_RS04390	COG1796	DNA polymerase
CP978_RS04390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CP978_RS04400	COG0437	4 iron, 4 sulfur cluster binding
CP978_RS04405	COG3383	formate dehydrogenase (NAD+) activity
CP978_RS04405	COG0243	molybdopterin cofactor binding
CP978_RS04415	COG1940	carbohydrate kinase activity
CP978_RS04435	COG2706	6-phosphogluconolactonase activity
CP978_RS04445	COG1357	PFAM Pentapeptide repeats (8 copies)
CP978_RS04450	COG1595	DNA-templated transcription, initiation
CP978_RS04460	COG1609	Transcriptional regulator
CP978_RS04465	COG1879	ABC-type sugar transport system periplasmic component
CP978_RS04475	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP978_RS04480	COG1129	ABC transporter
CP978_RS04490	COG3347	Dehydrogenase
CP978_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS04495	COG1070	Carbohydrate kinase
CP978_RS04500	COG0247	lactate metabolic process
CP978_RS04505	COG1139	Iron-sulfur cluster binding protein
CP978_RS04510	COG1556	Lactate utilization protein
CP978_RS04515	COG1125	glycine betaine transport
CP978_RS04515	COG0517	IMP dehydrogenase activity
CP978_RS04530	COG1174	glycine betaine transport
CP978_RS04535	COG1174	glycine betaine transport
CP978_RS04550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP978_RS04555	COG3281	Trehalose synthase
CP978_RS04560	COG0366	Alpha amylase catalytic
CP978_RS04565	COG0366	Alpha amylase catalytic
CP978_RS04575	COG0009	L-threonylcarbamoyladenylate synthase
CP978_RS04605	COG0516	GMP reductase activity
CP978_RS04605	COG0517	IMP dehydrogenase activity
CP978_RS04645	COG1366	Belongs to the anti-sigma-factor antagonist family
CP978_RS04645	COG2172	sigma factor antagonist activity
CP978_RS04645	COG2208	phosphoserine phosphatase activity
CP978_RS04650	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CP978_RS04680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CP978_RS04680	COG0517	IMP dehydrogenase activity
CP978_RS04680	COG0617	tRNA 3'-terminal CCA addition
CP978_RS04715	COG0309	Hydrogenase expression formation protein (HypE)
CP978_RS04720	COG0409	Hydrogenase expression formation protein
CP978_RS04725	COG0298	carbon dioxide binding
CP978_RS04735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP978_RS04740	COG0375	protein maturation
CP978_RS04755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP978_RS04755	COG1024	Enoyl-CoA hydratase
CP978_RS04770	COG2135	peptidase activity
CP978_RS04800	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CP978_RS04830	COG2159	amidohydrolase
CP978_RS04840	COG2124	cytochrome p450
CP978_RS04845	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CP978_RS04850	COG0730	response to heat
CP978_RS04855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP978_RS04855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP978_RS04870	COG0659	secondary active sulfate transmembrane transporter activity
CP978_RS04895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CP978_RS04900	COG1063	alcohol dehydrogenase
CP978_RS04915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP978_RS04920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP978_RS04930	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CP978_RS04935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP978_RS04945	COG0513	Belongs to the DEAD box helicase family
CP978_RS04965	COG2208	phosphoserine phosphatase activity
CP978_RS04965	COG2770	Histidine kinase
CP978_RS05050	COG0492	ferredoxin-NADP+ reductase activity
CP978_RS05115	COG0242	peptide deformylase activity
CP978_RS05125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP978_RS05130	COG1609	Transcriptional regulator
CP978_RS05140	COG2268	Band 7 protein
CP978_RS05155	COG0583	DNA-binding transcription factor activity
CP978_RS05175	COG3572	ergothioneine biosynthetic process
CP978_RS05180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP978_RS05185	COG0121	glutamine amidotransferase
CP978_RS05190	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP978_RS05195	COG2182	Extracellular solute-binding protein
CP978_RS05200	COG3360	Dodecin
CP978_RS05220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP978_RS05240	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CP978_RS05245	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CP978_RS05250	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CP978_RS05285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP978_RS05290	COG1053	succinate dehydrogenase
CP978_RS05300	COG0583	DNA-binding transcription factor activity
CP978_RS05345	COG0531	amino acid
CP978_RS05365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP978_RS05405	COG0395	ABC-type sugar transport system, permease component
CP978_RS05410	COG1175	transmembrane transport
CP978_RS05420	COG1609	Transcriptional regulator
CP978_RS05425	COG1349	DNA-binding transcription factor activity
CP978_RS05430	COG0531	amino acid
CP978_RS05435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP978_RS05455	COG1051	belongs to the nudix hydrolase family
CP978_RS05475	COG3537	Alpha-1,2-mannosidase
CP978_RS05495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CP978_RS05500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CP978_RS05545	COG0577	efflux transmembrane transporter activity
CP978_RS05545	COG1136	(ABC) transporter
CP978_RS05550	COG1136	(ABC) transporter
CP978_RS05550	COG4591	ABC-type transport system involved in lipoprotein release permease component
CP978_RS05595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP978_RS05630	COG1132	(ABC) transporter
CP978_RS05640	COG1024	Enoyl-CoA hydratase
CP978_RS05645	COG2838	Isocitrate dehydrogenase
CP978_RS05665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP978_RS05670	COG2814	Major facilitator Superfamily
CP978_RS05690	COG3485	protocatechuate 3,4-dioxygenase
CP978_RS05700	COG1902	pentaerythritol trinitrate reductase activity
CP978_RS05725	COG0492	ferredoxin-NADP+ reductase activity
CP978_RS05730	COG1793	dna ligase
CP978_RS05740	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS05750	COG3424	synthase
CP978_RS05755	COG2124	cytochrome p450
CP978_RS05765	COG1960	acyl-CoA dehydrogenase activity
CP978_RS05775	COG0242	peptide deformylase activity
CP978_RS05780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP978_RS05785	COG3442	glutamine amidotransferase
CP978_RS05790	COG0205	6-phosphofructokinase activity
CP978_RS05805	COG3275	phosphorelay sensor kinase activity
CP978_RS05810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP978_RS05820	COG3279	Response regulator of the LytR AlgR family
CP978_RS05825	COG1522	sequence-specific DNA binding
CP978_RS05830	COG1834	amidinotransferase
CP978_RS05835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP978_RS05845	COG0204	Acyl-transferase
CP978_RS05865	COG0740	serine-type endopeptidase activity
CP978_RS05900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP978_RS05905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP978_RS05910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP978_RS05915	COG2226	methyltransferase
CP978_RS05930	COG1136	(ABC) transporter
CP978_RS05930	COG0577	efflux transmembrane transporter activity
CP978_RS05945	COG2208	phosphoserine phosphatase activity
CP978_RS05945	COG2770	Histidine kinase
CP978_RS06005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP978_RS06020	COG1940	carbohydrate kinase activity
CP978_RS06025	COG2188	Transcriptional regulator
CP978_RS06030	COG0596	Alpha beta hydrolase
CP978_RS06045	COG0626	cystathionine gamma-synthase activity
CP978_RS06070	COG0419	ATPase involved in DNA repair
CP978_RS06075	COG0420	3'-5' exonuclease activity
CP978_RS06085	COG1739	Uncharacterized protein family UPF0029
CP978_RS06125	COG1132	(ABC) transporter
CP978_RS06135	COG1832	CoA-binding protein
CP978_RS06140	COG0531	amino acid
CP978_RS06155	COG3537	Alpha-1,2-mannosidase
CP978_RS06165	COG0842	Transport permease protein
CP978_RS06175	COG1846	Transcriptional regulator
CP978_RS06180	COG1230	cation diffusion facilitator family transporter
CP978_RS06195	COG0640	Transcriptional regulator
CP978_RS06260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP978_RS06270	COG0183	Belongs to the thiolase family
CP978_RS06280	COG1968	undecaprenyl-diphosphatase activity
CP978_RS06295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CP978_RS06305	COG2318	DinB family
CP978_RS06320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP978_RS06470	COG2239	Acts as a magnesium transporter
CP978_RS06475	COG2132	Multicopper oxidase
CP978_RS06510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP978_RS06510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP978_RS06520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CP978_RS06540	COG1716	ATPase activity
CP978_RS06560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP978_RS06590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP978_RS06600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP978_RS06630	COG2018	Roadblock/LC7 domain
CP978_RS06695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP978_RS06710	COG2270	Major facilitator Superfamily
CP978_RS06725	COG1216	Glycosyl transferase, family 2
CP978_RS06750	COG1960	acyl-CoA dehydrogenase activity
CP978_RS06795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP978_RS06800	COG0140	phosphoribosyl-ATP diphosphatase activity
CP978_RS06805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP978_RS06810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP978_RS06810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP978_RS06815	COG3201	nicotinamide mononucleotide transporter
CP978_RS06825	COG1846	Transcriptional regulator
CP978_RS06825	COG1940	carbohydrate kinase activity
CP978_RS06830	COG0738	Major facilitator superfamily
CP978_RS06835	COG2233	PERMEase
CP978_RS06850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP978_RS06855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP978_RS06860	COG3842	ATPase activity
CP978_RS06880	COG2188	Transcriptional regulator
CP978_RS06905	COG2390	Transcriptional regulator
CP978_RS06910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP978_RS06925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP978_RS06940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP978_RS06955	COG0194	GDP metabolic process
CP978_RS06965	COG0284	orotidine-5'-phosphate decarboxylase activity
CP978_RS06970	COG0167	dihydroorotate dehydrogenase activity
CP978_RS06975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP978_RS06980	COG0505	Belongs to the CarA family
CP978_RS06990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP978_RS06995	COG0540	Belongs to the ATCase OTCase family
CP978_RS07000	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CP978_RS07010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP978_RS07015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP978_RS07020	COG0006	proline dipeptidase activity
CP978_RS07030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP978_RS07035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP978_RS07040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP978_RS07045	COG0739	heme binding
CP978_RS07050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP978_RS07055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP978_RS07065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP978_RS07070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP978_RS07085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP978_RS07100	COG0124	histidyl-tRNA synthetase
CP978_RS07110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CP978_RS07115	COG1196	nuclear chromosome segregation
CP978_RS07120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP978_RS07125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP978_RS07130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP978_RS07135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP978_RS07145	COG2255	four-way junction helicase activity
CP978_RS07150	COG0632	four-way junction helicase activity
CP978_RS07155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP978_RS07160	COG0217	transcriptional regulatory protein
CP978_RS07165	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CP978_RS07170	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CP978_RS07180	COG0438	transferase activity, transferring glycosyl groups
CP978_RS07185	COG1560	Kdo2-lipid A biosynthetic process
CP978_RS07190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP978_RS07210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP978_RS07225	COG5002	protein histidine kinase activity
CP978_RS07225	COG2176	DNA-directed DNA polymerase activity
CP978_RS07280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP978_RS07325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP978_RS07325	COG1648	precorrin-2 dehydrogenase activity
CP978_RS07330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP978_RS07345	COG1464	Belongs to the NlpA lipoprotein family
CP978_RS07350	COG2011	ABC-type metal ion transport system permease component
CP978_RS07355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP978_RS07395	COG0204	Acyl-transferase
CP978_RS07395	COG0318	PFAM AMP-dependent synthetase and ligase
CP978_RS07400	COG0477	Major facilitator Superfamily
CP978_RS07415	COG0165	Argininosuccinate lyase
CP978_RS07420	COG0137	argininosuccinate synthase activity
CP978_RS07435	COG2205	protein histidine kinase activity
CP978_RS07440	COG0745	RESPONSE REGULATOR receiver
CP978_RS07470	COG1438	arginine binding
CP978_RS07475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP978_RS07480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP978_RS07485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP978_RS07490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP978_RS07510	COG0697	spore germination
CP978_RS07520	COG1649	PFAM Uncharacterised BCR, COG1649
CP978_RS07550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP978_RS07550	COG0072	phenylalanine-tRNA ligase activity
CP978_RS07555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP978_RS07560	COG5002	protein histidine kinase activity
CP978_RS07565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP978_RS07570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP978_RS07575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP978_RS07580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP978_RS07630	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS07635	COG0174	glutamine synthetase
CP978_RS07645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CP978_RS07665	COG2755	lipolytic protein G-D-S-L family
CP978_RS07665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP978_RS07680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP978_RS07690	COG4176	ABC-type proline glycine betaine transport system permease component
CP978_RS07695	COG3448	diguanylate cyclase activity
CP978_RS07695	COG4175	Glycine betaine
CP978_RS07700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP978_RS07730	COG0564	pseudouridine synthase activity
CP978_RS07765	COG0805	protein transport
CP978_RS07770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP978_RS07790	COG2378	regulation of single-species biofilm formation
CP978_RS07800	COG0545	Peptidyl-prolyl cis-trans isomerase
CP978_RS07805	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP978_RS07815	COG1609	Transcriptional regulator
CP978_RS07820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP978_RS07825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP978_RS07840	COG4122	O-methyltransferase activity
CP978_RS07845	COG1222	aaa ATPase
CP978_RS07870	COG0517	IMP dehydrogenase activity
CP978_RS07870	COG1994	Peptidase M50
CP978_RS07885	COG2197	response regulator
CP978_RS07890	COG4166	transmembrane transport
CP978_RS07905	COG1410	methionine synthase
CP978_RS07905	COG0646	methionine synthase
CP978_RS07910	COG1414	Transcriptional regulator
CP978_RS07915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP978_RS07920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP978_RS07925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP978_RS07935	COG0215	cysteine-tRNA ligase activity
CP978_RS07955	COG0598	Magnesium transport protein CorA
CP978_RS07965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS07970	COG0667	Aldo Keto reductase
CP978_RS08000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP978_RS08010	COG2824	Alkylphosphonate utilization operon protein PhnA
CP978_RS08025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CP978_RS08025	COG1796	DNA polymerase
CP978_RS08045	COG3012	SEC-C Motif Domain Protein
CP978_RS08050	COG2186	Transcriptional regulator
CP978_RS08055	COG3265	gluconokinase activity
CP978_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS08070	COG1063	alcohol dehydrogenase
CP978_RS08075	COG3573	Dehydrogenase
CP978_RS08085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP978_RS08090	COG2149	membrane
CP978_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS08160	COG0697	spore germination
CP978_RS08185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP978_RS08190	COG2188	Transcriptional regulator
CP978_RS08220	COG2755	lipolytic protein G-D-S-L family
CP978_RS08245	COG0726	polysaccharide deacetylase
CP978_RS08245	COG1649	PFAM Uncharacterised BCR, COG1649
CP978_RS08255	COG3664	PFAM glycoside hydrolase family 39
CP978_RS08270	COG1725	Transcriptional regulator
CP978_RS08295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CP978_RS08300	COG0587	DNA-directed DNA polymerase activity
CP978_RS08320	COG1799	cell septum assembly
CP978_RS08325	COG0477	Major facilitator Superfamily
CP978_RS08335	COG0671	phosphoesterase, PA-phosphatase related
CP978_RS08345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP978_RS08360	COG1160	GTP binding
CP978_RS08370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP978_RS08390	COG1056	cytidyltransferase-related domain
CP978_RS08390	COG1051	belongs to the nudix hydrolase family
CP978_RS08395	COG1187	pseudouridine synthase activity
CP978_RS08400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP978_RS08405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP978_RS08420	COG0686	Belongs to the AlaDH PNT family
CP978_RS08430	COG0494	nUDIX hydrolase
CP978_RS08435	COG0504	CTP synthase activity
CP978_RS08440	COG3387	PFAM Glycoside hydrolase 15-related
CP978_RS08450	COG0438	transferase activity, transferring glycosyl groups
CP978_RS08460	COG0497	DNA recombination
CP978_RS08465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP978_RS08485	COG1120	ATPase activity
CP978_RS08490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS08495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS08500	COG0647	UMP catabolic process
CP978_RS08545	COG2094	Belongs to the DNA glycosylase MPG family
CP978_RS08555	COG1881	PFAM PEBP family protein
CP978_RS08575	COG1119	ATPase activity
CP978_RS08585	COG2197	response regulator
CP978_RS08600	COG1716	ATPase activity
CP978_RS08600	COG1131	(ABC) transporter
CP978_RS08600	COG0842	Transport permease protein
CP978_RS08605	COG3830	Belongs to the UPF0237 family
CP978_RS08605	COG0560	Phosphoserine phosphatase
CP978_RS08610	COG0588	phosphoglycerate mutase activity
CP978_RS08630	COG2186	Transcriptional regulator
CP978_RS08645	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS08650	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
CP978_RS08695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP978_RS08715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP978_RS08720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP978_RS08740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP978_RS08755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP978_RS08770	COG3387	PFAM Glycoside hydrolase 15-related
CP978_RS08810	COG0488	(ABC) transporter
CP978_RS08825	COG0235	Class ii aldolase
CP978_RS08865	COG1492	cobalamin metabolic process
CP978_RS08885	COG1797	cobyrinic acid a,c-diamide synthase activity
CP978_RS08920	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CP978_RS08975	COG1857	crispr-associated protein
CP978_RS08995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP978_RS09005	COG1126	abc transporter atp-binding protein
CP978_RS09010	COG0765	amino acid transport
CP978_RS09015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP978_RS09020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CP978_RS09025	COG0456	acetyltransferase
CP978_RS09030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP978_RS09035	COG1917	Cupin 2, conserved barrel domain protein
CP978_RS09040	COG5285	phytanoyl-CoA dioxygenase
CP978_RS09045	COG0156	8-amino-7-oxononanoate synthase activity
CP978_RS09070	COG1414	Transcriptional regulator
CP978_RS09075	COG0768	penicillin binding
CP978_RS09085	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CP978_RS09115	COG1653	transport
CP978_RS09130	COG0395	ABC-type sugar transport system, permease component
CP978_RS09135	COG1175	transmembrane transport
CP978_RS09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP978_RS09150	COG1802	Transcriptional regulator
CP978_RS09165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP978_RS09170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP978_RS09175	COG1349	DNA-binding transcription factor activity
CP978_RS09190	COG0395	ABC-type sugar transport system, permease component
CP978_RS09195	COG1063	alcohol dehydrogenase
CP978_RS09225	COG0321	lipoyl(octanoyl) transferase activity
CP978_RS09230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP978_RS09265	COG2171	N-acyltransferase activity
CP978_RS09270	COG3226	Transcriptional regulator
CP978_RS09275	COG2076	Multidrug Resistance protein
CP978_RS09280	COG2151	metal-sulfur cluster biosynthetic enzyme
CP978_RS09285	COG0822	iron-sulfur transferase activity
CP978_RS09290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP978_RS09295	COG0396	ATPase activity
CP978_RS09305	COG0719	Fe-S assembly protein
CP978_RS09320	COG2746	aminoglycoside 3-N-acetyltransferase activity
CP978_RS09350	COG0109	protoheme IX farnesyltransferase activity
CP978_RS09360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP978_RS09375	COG0363	glucosamine-6-phosphate deaminase activity
CP978_RS09385	COG0395	ABC-type sugar transport system, permease component
CP978_RS09390	COG1175	transmembrane transport
CP978_RS09395	COG1653	transport
CP978_RS09400	COG0366	Alpha amylase catalytic
CP978_RS09415	COG1695	Transcriptional regulator
CP978_RS09420	COG1136	(ABC) transporter
CP978_RS09430	COG0166	Belongs to the GPI family
CP978_RS09440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP978_RS09445	COG0149	triose-phosphate isomerase activity
CP978_RS09450	COG0126	phosphoglycerate kinase activity
CP978_RS09455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP978_RS09460	COG1481	regulation of sporulation
CP978_RS09465	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP978_RS09470	COG1660	Displays ATPase and GTPase activities
CP978_RS09475	COG0322	excinuclease ABC activity
CP978_RS09500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP978_RS09515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP978_RS09520	COG0765	amino acid transport
CP978_RS09525	COG1126	abc transporter atp-binding protein
CP978_RS09530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP978_RS09535	COG0387	Pfam Sodium calcium exchanger
CP978_RS09555	COG0556	nucleotide-excision repair
CP978_RS09565	COG0584	glycerophosphoryl diester phosphodiesterase
CP978_RS09570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP978_RS09640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP978_RS09655	COG0237	dephospho-CoA kinase activity
CP978_RS09665	COG0539	negative regulation of cytoplasmic translation
CP978_RS09670	COG2226	methyltransferase
CP978_RS09675	COG1643	Atp-dependent helicase
CP978_RS09705	COG2050	protein possibly involved in aromatic compounds catabolism
CP978_RS09730	COG0411	ABC transporter
CP978_RS09760	COG0737	Belongs to the 5'-nucleotidase family
CP978_RS09780	COG0287	Prephenate dehydrogenase
CP978_RS09780	COG1605	Chorismate mutase
CP978_RS09805	COG0069	glutamate synthase activity
CP978_RS09805	COG0070	glutamate synthase
CP978_RS09805	COG0067	glutamate synthase
CP978_RS09835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP978_RS09840	COG2301	Belongs to the HpcH HpaI aldolase family
CP978_RS09845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP978_RS09855	COG0159	tryptophan synthase activity
CP978_RS09860	COG0133	tryptophan synthase activity
CP978_RS09870	COG0134	indole-3-glycerol-phosphate synthase activity
CP978_RS09895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP978_RS09915	COG0107	imidazoleglycerol-phosphate synthase activity
CP978_RS09920	COG0251	oxidation-reduction process
CP978_RS09925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP978_RS09930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP978_RS09935	COG0131	Imidazoleglycerol-phosphate dehydratase
CP978_RS09940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP978_RS09945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP978_RS09965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CP978_RS09985	COG1432	Conserved Protein
CP978_RS09995	COG0587	DNA-directed DNA polymerase activity
CP978_RS10045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP978_RS10060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP978_RS10065	COG3599	regulation of cell shape
CP978_RS10075	COG1799	cell septum assembly
CP978_RS10080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CP978_RS10085	COG1496	oxidoreductase activity
CP978_RS10090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CP978_RS10095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP978_RS10100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP978_RS10110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP978_RS10115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP978_RS10125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP978_RS10130	COG0768	penicillin binding
CP978_RS10140	COG0275	rRNA processing
CP978_RS10150	COG0714	Associated with various cellular activities
CP978_RS10170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP978_RS10195	COG0352	thiamine-phosphate diphosphorylase activity
CP978_RS10210	COG2022	thiamine diphosphate biosynthetic process
CP978_RS10210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP978_RS10220	COG2022	thiamine diphosphate biosynthetic process
CP978_RS10225	COG0515	serine threonine protein kinase
CP978_RS10225	COG2815	serine threonine protein kinase
CP978_RS10230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CP978_RS10235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP978_RS10240	COG2193	ferroxidase activity
CP978_RS10245	COG0243	molybdopterin cofactor binding
CP978_RS10250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP978_RS10265	COG0205	6-phosphofructokinase activity
CP978_RS10270	COG2197	response regulator
CP978_RS10275	COG4585	Histidine kinase
CP978_RS10300	COG1940	carbohydrate kinase activity
CP978_RS10310	COG0003	Pfam Anion-transporting ATPase
CP978_RS10330	COG0438	transferase activity, transferring glycosyl groups
CP978_RS10345	COG3883	PFAM NLP P60 protein
CP978_RS10345	COG0791	NLP P60 protein
CP978_RS10375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP978_RS10380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP978_RS10385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP978_RS10390	COG0723	plastoquinol--plastocyanin reductase activity
CP978_RS10395	COG2010	Cytochrome c
CP978_RS10400	COG1845	cytochrome c oxidase, subunit III
CP978_RS10410	COG1376	ErfK ybiS ycfS ynhG family protein
CP978_RS10420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP978_RS10425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP978_RS10435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP978_RS10455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CP978_RS10460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP978_RS10465	COG2197	response regulator
CP978_RS10470	COG3851	Histidine kinase
CP978_RS10495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP978_RS10515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP978_RS10520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP978_RS10520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP978_RS10530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CP978_RS10540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP978_RS10545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP978_RS10550	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP978_RS10560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP978_RS10590	COG1090	epimerase
CP978_RS10605	COG0321	lipoyl(octanoyl) transferase activity
CP978_RS10610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP978_RS10630	COG0174	glutamine synthetase
CP978_RS10635	COG0501	Belongs to the peptidase M48B family
CP978_RS10665	COG0745	RESPONSE REGULATOR receiver
CP978_RS10685	COG1309	transcriptional regulator
CP978_RS10705	COG0366	Alpha amylase catalytic
CP978_RS10710	COG3833	ABC-type maltose transport systems, permease component
CP978_RS10715	COG1175	transmembrane transport
CP978_RS10725	COG1609	Transcriptional regulator
CP978_RS10735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP978_RS10750	COG0174	glutamine synthetase
CP978_RS10755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP978_RS10755	COG1017	nitric oxide dioxygenase activity
CP978_RS10760	COG1959	2 iron, 2 sulfur cluster binding
CP978_RS10780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP978_RS10780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP978_RS10785	COG2814	Major facilitator Superfamily
CP978_RS10795	COG1309	transcriptional regulator
CP978_RS10800	COG0477	Major facilitator Superfamily
CP978_RS10805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP978_RS10825	COG1994	Peptidase M50
CP978_RS10855	COG0384	phenazine biosynthesis protein PhzF
CP978_RS10865	COG2837	iron assimilation
CP978_RS10870	COG0672	)-iron permease
CP978_RS10890	COG1595	DNA-templated transcription, initiation
CP978_RS10910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP978_RS10915	COG2814	Major facilitator Superfamily
CP978_RS10920	COG1686	Belongs to the peptidase S11 family
CP978_RS10925	COG2259	Doxx family
CP978_RS11005	COG3547	Transposase (IS116 IS110 IS902 family)
CP978_RS11045	COG1725	Transcriptional regulator
CP978_RS11050	COG3022	response to hydroperoxide
CP978_RS11055	COG0800	Aldolase
CP978_RS11070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CP978_RS11085	COG2030	dehydratase
CP978_RS11090	COG1131	(ABC) transporter
CP978_RS11095	COG0842	Transport permease protein
CP978_RS11100	COG4585	Histidine kinase
CP978_RS11105	COG2197	response regulator
CP978_RS11110	COG0477	Major facilitator Superfamily
CP978_RS11120	COG0860	N-Acetylmuramoyl-L-alanine amidase
CP978_RS11120	COG2247	cell wall binding repeat
CP978_RS11145	COG0438	transferase activity, transferring glycosyl groups
CP978_RS11150	COG1309	transcriptional regulator
CP978_RS11155	COG1657	PFAM Prenyltransferase squalene oxidase
CP978_RS11170	COG3845	ABC transporter
CP978_RS11185	COG3619	membrane
CP978_RS11190	COG0477	Major facilitator Superfamily
CP978_RS11195	COG4122	O-methyltransferase activity
CP978_RS11225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP978_RS11260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP978_RS11265	COG0583	DNA-binding transcription factor activity
CP978_RS11270	COG1335	isochorismatase
CP978_RS11275	COG0477	Major facilitator Superfamily
CP978_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS11320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP978_RS11385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP978_RS11400	COG1358	cellular component organization or biogenesis
CP978_RS11450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP978_RS11455	COG0477	Major facilitator Superfamily
CP978_RS11460	COG1309	transcriptional regulator
CP978_RS11475	COG0789	Transcriptional regulator
CP978_RS11495	COG1741	Belongs to the pirin family
CP978_RS11510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP978_RS11515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP978_RS11520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP978_RS11545	COG2130	NADP-dependent
CP978_RS11550	COG1846	Transcriptional regulator
CP978_RS11565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP978_RS11570	COG3953	SLT domain
CP978_RS11570	COG5280	Phage tail tape measure protein TP901
CP978_RS11590	COG0318	PFAM AMP-dependent synthetase and ligase
CP978_RS11595	COG1077	Cell shape determining protein MreB Mrl
CP978_RS11625	COG1070	Carbohydrate kinase
CP978_RS11640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP978_RS11645	COG0358	DNA primase activity
CP978_RS11655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP978_RS11660	COG2949	membrane
CP978_RS11690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP978_RS11690	COG0574	Belongs to the PEP-utilizing enzyme family
CP978_RS11715	COG0423	glycine-tRNA ligase activity
CP978_RS11720	COG3443	Belongs to the bacterial solute-binding protein 9 family
CP978_RS11720	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP978_RS11725	COG1121	(ABC) transporter
CP978_RS11730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP978_RS11745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP978_RS11750	COG1381	Involved in DNA repair and RecF pathway recombination
CP978_RS11780	COG2197	response regulator
CP978_RS11785	COG4585	Histidine kinase
CP978_RS11790	COG1131	(ABC) transporter
CP978_RS11830	COG0456	acetyltransferase
CP978_RS11850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP978_RS11880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP978_RS11895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP978_RS11905	COG4948	Mandelate Racemase Muconate Lactonizing
CP978_RS11915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP978_RS11920	COG1234	tRNA 3'-trailer cleavage
CP978_RS11925	COG0537	adenosine 5'-monophosphoramidase activity
CP978_RS11930	COG0793	Belongs to the peptidase S41A family
CP978_RS11930	COG4946	Tricorn protease homolog
CP978_RS11950	COG0484	heat shock protein binding
CP978_RS11955	COG1420	regulation of RNA biosynthetic process
CP978_RS11985	COG0481	GTPase activity
CP978_RS11995	COG0268	Binds directly to 16S ribosomal RNA
CP978_RS12030	COG1307	EDD domain protein, DegV family
CP978_RS12040	COG0495	leucyl-tRNA aminoacylation
CP978_RS12050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP978_RS12070	COG0588	phosphoglycerate mutase activity
CP978_RS12075	COG0799	negative regulation of ribosome biogenesis
CP978_RS12085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP978_RS12090	COG0501	Belongs to the peptidase M48B family
CP978_RS12105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP978_RS12115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP978_RS12125	COG1215	transferase activity, transferring glycosyl groups
CP978_RS12130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP978_RS12135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP978_RS12140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP978_RS12145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP978_RS12150	COG1530	ribonuclease E activity
CP978_RS12170	COG1785	Belongs to the alkaline phosphatase family
CP978_RS12205	COG0640	Transcriptional regulator
CP978_RS12215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP978_RS12220	COG0456	acetyltransferase
CP978_RS12235	COG0772	Belongs to the SEDS family
CP978_RS12240	COG0768	penicillin binding
CP978_RS12255	COG1077	Cell shape determining protein MreB Mrl
CP978_RS12260	COG0105	UTP biosynthetic process
CP978_RS12270	COG0285	dihydrofolate synthase activity
CP978_RS12275	COG0525	valine-tRNA ligase activity
CP978_RS12285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP978_RS12290	COG0740	serine-type endopeptidase activity
CP978_RS12295	COG0740	serine-type endopeptidase activity
CP978_RS12300	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP978_RS12320	COG3594	Acyltransferase
CP978_RS12335	COG0698	ribose 5-phosphate isomerase
CP978_RS12345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CP978_RS12350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP978_RS12385	COG0667	Aldo Keto reductase
CP978_RS12400	COG0697	spore germination
CP978_RS12405	COG1846	Transcriptional regulator
CP978_RS12410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP978_RS12430	COG1595	DNA-templated transcription, initiation
CP978_RS12440	COG1131	(ABC) transporter
CP978_RS12480	COG0668	transmembrane transport
CP978_RS12495	COG1175	transmembrane transport
CP978_RS12500	COG0395	ABC-type sugar transport system, permease component
CP978_RS12505	COG1486	melibiose metabolic process
CP978_RS12520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP978_RS12625	COG0714	Associated with various cellular activities
CP978_RS12640	COG0629	single-stranded DNA binding
CP978_RS12745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CP978_RS12755	COG1129	ABC transporter
CP978_RS12765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP978_RS12770	COG1869	D-ribose catabolic process
CP978_RS12785	COG0673	inositol 2-dehydrogenase activity
CP978_RS12795	COG2197	response regulator
CP978_RS12800	COG4585	Histidine kinase
CP978_RS12805	COG0577	efflux transmembrane transporter activity
CP978_RS12805	COG1136	(ABC) transporter
CP978_RS12850	COG0028	Belongs to the TPP enzyme family
CP978_RS12860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP978_RS12885	COG1309	transcriptional regulator
CP978_RS12890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP978_RS12905	COG1960	acyl-CoA dehydrogenase activity
CP978_RS12930	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP978_RS12955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP978_RS12965	COG0589	response to stress
CP978_RS12980	COG4977	sequence-specific DNA binding
CP978_RS12985	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CP978_RS12995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP978_RS13000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP978_RS13030	COG3311	Transcriptional regulator
CP978_RS13055	COG0395	ABC-type sugar transport system, permease component
CP978_RS13070	COG0745	RESPONSE REGULATOR receiver
CP978_RS13095	COG0406	alpha-ribazole phosphatase activity
CP978_RS13145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS13215	COG1940	carbohydrate kinase activity
CP978_RS13220	COG0673	inositol 2-dehydrogenase activity
CP978_RS13225	COG4702	Belongs to the UPF0303 family
CP978_RS13270	COG4249	Peptidase C14 caspase catalytic subunit p20
CP978_RS13270	COG2319	Wd-40 repeat
CP978_RS13320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP978_RS13350	COG2733	membrane
CP978_RS13360	COG1131	(ABC) transporter
CP978_RS13375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP978_RS13415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP978_RS13430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP978_RS13435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP978_RS13440	COG1263	PTS System
CP978_RS13470	COG1113	amino acid transport
CP978_RS13480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP978_RS13500	COG1335	isochorismatase
CP978_RS13535	COG0277	FAD linked oxidase domain protein
CP978_RS13540	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP978_RS13550	COG1174	glycine betaine transport
CP978_RS13565	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP978_RS13580	COG3654	unkown
CP978_RS13620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP978_RS13630	COG1678	Uncharacterized ACR, COG1678
CP978_RS13635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP978_RS13640	COG0776	regulation of translation
CP978_RS13650	COG3973	AAA domain
CP978_RS13680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CP978_RS13685	COG0745	RESPONSE REGULATOR receiver
CP978_RS13690	COG5000	phosphorelay sensor kinase activity
CP978_RS13690	COG5002	protein histidine kinase activity
CP978_RS13695	COG0823	Involved in the tonB-independent uptake of proteins
CP978_RS13705	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP978_RS13710	COG2197	response regulator
CP978_RS13715	COG3214	Protein conserved in bacteria
CP978_RS13725	COG0653	protein targeting
CP978_RS13750	COG2902	Dehydrogenase
CP978_RS13765	COG1215	transferase activity, transferring glycosyl groups
CP978_RS13770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP978_RS13775	COG1134	teichoic acid transport
CP978_RS13785	COG1309	transcriptional regulator
CP978_RS13795	COG1215	transferase activity, transferring glycosyl groups
CP978_RS13835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP978_RS13840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP978_RS13845	COG0463	Glycosyl transferase, family 2
CP978_RS13845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP978_RS13850	COG1674	ftsk spoiiie
CP978_RS13855	COG0515	serine threonine protein kinase
CP978_RS13860	COG0515	serine threonine protein kinase
CP978_RS13865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP978_RS13880	COG2884	Cell division ATP-binding protein ftsE
CP978_RS13890	COG0793	Belongs to the peptidase S41A family
CP978_RS13895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP978_RS13905	COG4585	Histidine kinase
CP978_RS13920	COG2197	response regulator
CP978_RS13955	COG0583	DNA-binding transcription factor activity
CP978_RS13985	COG0714	Associated with various cellular activities
CP978_RS14050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP978_RS14070	COG1482	cell wall glycoprotein biosynthetic process
CP978_RS14080	COG2835	tetraacyldisaccharide 4'-kinase activity
CP978_RS14125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP978_RS14130	COG0778	Nitroreductase
CP978_RS14130	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CP978_RS14155	COG1316	TRANSCRIPTIONal
CP978_RS14160	COG1316	TRANSCRIPTIONal
CP978_RS14175	COG0463	Glycosyl transferase, family 2
CP978_RS14180	COG1316	TRANSCRIPTIONal
CP978_RS14185	COG1607	acyl-coa hydrolase
CP978_RS14190	COG1316	TRANSCRIPTIONal
CP978_RS14205	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP978_RS14225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CP978_RS14240	COG2205	protein histidine kinase activity
CP978_RS14245	COG0745	RESPONSE REGULATOR receiver
CP978_RS14250	COG3104	oligopeptide transport
CP978_RS14260	COG1366	Belongs to the anti-sigma-factor antagonist family
CP978_RS14265	COG1191	sigma factor activity
CP978_RS14270	COG1228	amidohydrolase
CP978_RS14285	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CP978_RS14335	COG2755	lipolytic protein G-D-S-L family
CP978_RS14340	COG0183	Belongs to the thiolase family
CP978_RS14425	COG1136	(ABC) transporter
CP978_RS14425	COG0577	efflux transmembrane transporter activity
CP978_RS14430	COG0577	efflux transmembrane transporter activity
CP978_RS14435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP978_RS14440	COG1252	NADH dehydrogenase
CP978_RS14460	COG0148	phosphopyruvate hydratase activity
CP978_RS14475	COG2124	cytochrome p450
CP978_RS14555	COG0577	efflux transmembrane transporter activity
CP978_RS14560	COG1136	(ABC) transporter
CP978_RS14595	COG4585	Histidine kinase
CP978_RS14605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP978_RS14610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP978_RS14615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP978_RS14620	COG0193	aminoacyl-tRNA hydrolase activity
CP978_RS14630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CP978_RS14640	COG1309	transcriptional regulator
CP978_RS14645	COG4106	trans-aconitate 2-methyltransferase activity
CP978_RS14655	COG2197	response regulator
CP978_RS14665	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CP978_RS14695	COG0488	(ABC) transporter
CP978_RS14700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP978_RS14715	COG0084	hydrolase, TatD family'
CP978_RS14740	COG0768	penicillin binding
CP978_RS14750	COG0442	prolyl-tRNA aminoacylation
CP978_RS14760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP978_RS14775	COG1122	ATPase activity
CP978_RS14785	COG0310	cobalt ion transport
CP978_RS14795	COG2409	Drug exporters of the RND superfamily
CP978_RS14815	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS14820	COG2072	flavoprotein involved in K transport
CP978_RS14855	COG0315	cyclic pyranopterin monophosphate synthase activity
CP978_RS14855	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP978_RS14860	COG0315	cyclic pyranopterin monophosphate synthase activity
CP978_RS14870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP978_RS14875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP978_RS14900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CP978_RS14910	COG1970	mechanosensitive ion channel activity
CP978_RS14920	COG3191	aminopeptidase activity
CP978_RS14930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP978_RS14930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP978_RS14930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP978_RS14940	COG1349	DNA-binding transcription factor activity
CP978_RS14945	COG0477	Major facilitator Superfamily
CP978_RS14960	COG3384	dioxygenase
CP978_RS14965	COG1846	Transcriptional regulator
CP978_RS14985	COG1414	Transcriptional regulator
CP978_RS15010	COG2186	Transcriptional regulator
CP978_RS15095	COG4941	Belongs to the sigma-70 factor family
CP978_RS15100	COG3795	YCII-related domain
CP978_RS15105	COG0202	RNA polymerase activity
CP978_RS15140	COG0386	Belongs to the glutathione peroxidase family
CP978_RS15150	COG1686	Belongs to the peptidase S11 family
CP978_RS15180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP978_RS15195	COG3629	intracellular signal transduction
CP978_RS15195	COG3903	Transcriptional regulator
CP978_RS15205	COG0515	serine threonine protein kinase
CP978_RS15205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP978_RS15215	COG1309	transcriptional regulator
CP978_RS15220	COG0259	pyridoxamine-phosphate oxidase activity
CP978_RS15330	COG4821	SIS domain
CP978_RS15340	COG0596	Alpha beta hydrolase
CP978_RS15340	COG2945	thiolester hydrolase activity
CP978_RS15345	COG0259	pyridoxamine-phosphate oxidase activity
CP978_RS15365	COG1024	Enoyl-CoA hydratase
CP978_RS15380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP978_RS15395	COG0277	FAD linked oxidase domain protein
CP978_RS15395	COG0247	lactate metabolic process
CP978_RS15400	COG0642	Histidine kinase
CP978_RS15425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP978_RS15430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CP978_RS15460	COG0667	Aldo Keto reductase
CP978_RS15465	COG2208	phosphoserine phosphatase activity
CP978_RS15475	COG2188	Transcriptional regulator
CP978_RS15500	COG0675	Transposase, IS605 OrfB family
CP978_RS15505	COG2252	PERMEase
CP978_RS15515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP978_RS15535	COG2814	Major facilitator Superfamily
CP978_RS15545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP978_RS15550	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP978_RS15555	COG1278	Cold shock
CP978_RS15580	COG1061	Type III restriction enzyme res subunit
CP978_RS15590	COG3973	AAA domain
CP978_RS15595	COG3142	Participates in the control of copper homeostasis
CP978_RS15625	COG1737	Transcriptional regulator
CP978_RS15630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CP978_RS15680	COG0477	Major facilitator Superfamily
CP978_RS15685	COG0459	protein refolding
CP978_RS15690	COG1278	Cold shock
CP978_RS15705	COG0463	Glycosyl transferase, family 2
CP978_RS15730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CP978_RS15735	COG1105	Belongs to the carbohydrate kinase PfkB family
CP978_RS15740	COG0583	DNA-binding transcription factor activity
CP978_RS15755	COG0590	tRNA wobble adenosine to inosine editing
CP978_RS15765	COG0666	response to abiotic stimulus
CP978_RS15780	COG2197	response regulator
CP978_RS15800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP978_RS15875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP978_RS15880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP978_RS15890	COG0662	Cupin 2, conserved barrel domain protein
CP978_RS15935	COG3842	ATPase activity
CP978_RS15960	COG0215	cysteine-tRNA ligase activity
CP978_RS15965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP978_RS15970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP978_RS15975	COG1329	Transcriptional regulator
CP978_RS15995	COG5002	protein histidine kinase activity
CP978_RS16040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CP978_RS16065	COG0588	phosphoglycerate mutase activity
CP978_RS16090	COG0438	transferase activity, transferring glycosyl groups
CP978_RS16150	COG2188	Transcriptional regulator
CP978_RS16155	COG4552	Acetyltransferase involved in intracellular survival and related
CP978_RS16170	COG1490	D-aminoacyl-tRNA deacylase activity
CP978_RS16185	COG3485	protocatechuate 3,4-dioxygenase
CP978_RS16225	COG2897	thiosulfate sulfurtransferase activity
CP978_RS16250	COG0745	RESPONSE REGULATOR receiver
CP978_RS16255	COG1609	Transcriptional regulator
CP978_RS16260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP978_RS16270	COG0745	RESPONSE REGULATOR receiver
CP978_RS16280	COG0737	Belongs to the 5'-nucleotidase family
CP978_RS16285	COG0456	acetyltransferase
CP978_RS16300	COG1131	(ABC) transporter
CP978_RS16315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CP978_RS16345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP978_RS16355	COG0306	phosphate transporter
CP978_RS16365	COG1937	Protein conserved in bacteria
CP978_RS16375	COG0277	FAD linked oxidase domain protein
CP978_RS16380	COG0671	phosphoesterase, PA-phosphatase related
CP978_RS16385	COG0739	heme binding
CP978_RS16385	COG1196	nuclear chromosome segregation
CP978_RS16385	COG0741	lytic transglycosylase activity
CP978_RS16465	COG1252	NADH dehydrogenase
CP978_RS16490	COG0579	oxidoreductase
CP978_RS16495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP978_RS16505	COG0667	Aldo Keto reductase
CP978_RS16525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP978_RS16525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP978_RS16545	COG2197	response regulator
CP978_RS16570	COG0513	Belongs to the DEAD box helicase family
CP978_RS16615	COG1643	Atp-dependent helicase
CP978_RS16650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP978_RS16670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP978_RS16675	COG0047	phosphoribosylformylglycinamidine synthase activity
CP978_RS16680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP978_RS16705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP978_RS16720	COG0151	Belongs to the GarS family
CP978_RS16745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP978_RS16760	COG0395	ABC-type sugar transport system, permease component
CP978_RS16765	COG1175	transmembrane transport
CP978_RS16775	COG1276	copper resistance
CP978_RS16775	COG2372	response to copper ion
CP978_RS16800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CP978_RS16830	COG1191	sigma factor activity
CP978_RS16835	COG1191	sigma factor activity
CP978_RS16860	COG3467	pyridoxamine 5'-phosphate
CP978_RS16870	COG0477	Major facilitator Superfamily
CP978_RS16875	COG0745	RESPONSE REGULATOR receiver
CP978_RS16885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP978_RS16890	COG2318	DinB family
CP978_RS16910	COG0784	Response regulator, receiver
CP978_RS16915	COG0318	PFAM AMP-dependent synthetase and ligase
CP978_RS16920	COG1595	DNA-templated transcription, initiation
CP978_RS16960	COG0515	serine threonine protein kinase
CP978_RS17030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP978_RS17045	COG0653	protein targeting
CP978_RS17065	COG0006	proline dipeptidase activity
CP978_RS17085	COG1999	signal sequence binding
CP978_RS17100	COG2837	iron assimilation
CP978_RS17105	COG0077	Prephenate dehydratase
CP978_RS17110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP978_RS17115	COG0561	phosphatase activity
CP978_RS17135	COG1131	(ABC) transporter
CP978_RS17155	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CP978_RS17165	COG0561	phosphatase activity
CP978_RS17170	COG4988	ABC transporter
CP978_RS17175	COG1294	oxidase, subunit
CP978_RS17180	COG1271	oxidase subunit
CP978_RS17185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP978_RS17190	COG1609	Transcriptional regulator
CP978_RS17205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP978_RS17230	COG0662	Cupin 2, conserved barrel domain protein
CP978_RS17235	COG1950	PFAM Membrane protein of
CP978_RS17240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP978_RS17245	COG0626	cystathionine gamma-synthase activity
CP978_RS17285	COG0305	Participates in initiation and elongation during chromosome replication
CP978_RS17290	COG0534	Mate efflux family protein
CP978_RS17295	COG0359	binds to the 23S rRNA
CP978_RS17300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP978_RS17305	COG0629	single-stranded DNA binding
CP978_RS17310	COG0360	Binds together with S18 to 16S ribosomal RNA
CP978_RS17335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP978_RS17345	COG1260	myo-inositol-1-phosphate synthase
CP978_RS17355	COG0617	tRNA 3'-terminal CCA addition
CP978_RS17370	COG2815	serine threonine protein kinase
CP978_RS17370	COG0515	serine threonine protein kinase
CP978_RS17375	COG1595	DNA-templated transcription, initiation
CP978_RS17385	COG0492	ferredoxin-NADP+ reductase activity
CP978_RS17390	COG3118	belongs to the thioredoxin family
CP978_RS17405	COG1192	Involved in chromosome partitioning
CP978_RS17410	COG0357	Ribosomal RNA small subunit methyltransferase G
CP978_RS17420	COG0706	membrane insertase activity
CP978_RS17425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CP978_RS17430	COG0594	ribonuclease P activity
CP978_RS17435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CP978_RS17440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CP978_RS17450	COG0592	DNA-directed DNA polymerase activity
CP978_RS17455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP978_RS17460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP978_RS17465	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CP978_RS17470	COG0187	DNA topoisomerase II activity
CP978_RS17475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP978_RS17495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP978_RS17500	COG0765	amino acid transport
CP978_RS17505	COG0765	amino acid transport
CP978_RS17510	COG1126	abc transporter atp-binding protein
CP978_RS17535	COG0515	serine threonine protein kinase
CP978_RS17560	COG0705	Rhomboid family
CP978_RS17590	COG3764	Sortase (surface protein transpeptidase)
CP978_RS17595	COG3764	Sortase (surface protein transpeptidase)
CP978_RS17600	COG0515	serine threonine protein kinase
CP978_RS17610	COG0768	penicillin binding
CP978_RS17625	COG1716	ATPase activity
CP978_RS17630	COG1716	ATPase activity
CP978_RS17655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP978_RS17690	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP978_RS17695	COG1309	transcriptional regulator
CP978_RS17700	COG1522	sequence-specific DNA binding
CP978_RS17725	COG0303	'Molybdopterin
CP978_RS17730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP978_RS17735	COG3321	synthase
CP978_RS17735	COG0604	alcohol dehydrogenase
CP978_RS17735	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS17755	COG0515	serine threonine protein kinase
CP978_RS17760	COG0515	serine threonine protein kinase
CP978_RS17765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CP978_RS17775	COG0022	dehydrogenase e1 component
CP978_RS17780	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP978_RS17820	COG1362	aminopeptidase activity
CP978_RS17825	COG1960	acyl-CoA dehydrogenase activity
CP978_RS17835	COG1741	Belongs to the pirin family
CP978_RS17850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP978_RS17855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP978_RS17905	COG1396	sequence-specific DNA binding
CP978_RS17910	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CP978_RS17920	COG0701	Predicted permease
CP978_RS17930	COG2815	serine threonine protein kinase
CP978_RS17930	COG0515	serine threonine protein kinase
CP978_RS17940	COG0367	asparagine synthase
CP978_RS17950	COG2264	protein methyltransferase activity
CP978_RS17960	COG0297	glycogen (starch) synthase activity
CP978_RS18000	COG0783	Belongs to the Dps family
CP978_RS18005	COG2205	protein histidine kinase activity
CP978_RS18010	COG0745	RESPONSE REGULATOR receiver
CP978_RS18025	COG0577	efflux transmembrane transporter activity
CP978_RS18025	COG1136	(ABC) transporter
CP978_RS18030	COG1136	(ABC) transporter
CP978_RS18030	COG0577	efflux transmembrane transporter activity
CP978_RS18050	COG3250	beta-galactosidase activity
CP978_RS18095	COG0745	RESPONSE REGULATOR receiver
CP978_RS18100	COG5002	protein histidine kinase activity
CP978_RS18120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP978_RS18120	COG0515	serine threonine protein kinase
CP978_RS18135	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CP978_RS18140	COG1396	sequence-specific DNA binding
CP978_RS18150	COG0717	Belongs to the dCTP deaminase family
CP978_RS18170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP978_RS18175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP978_RS18190	COG0438	transferase activity, transferring glycosyl groups
CP978_RS18195	COG2181	nitrate reductase activity
CP978_RS18195	COG0247	lactate metabolic process
CP978_RS18205	COG0489	protein tyrosine kinase activity
CP978_RS18215	COG0443	Heat shock 70 kDa protein
CP978_RS18220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP978_RS18225	COG0484	heat shock protein binding
CP978_RS18230	COG0789	Transcriptional regulator
CP978_RS18235	COG4213	ABC transporter substrate-binding protein
CP978_RS18260	COG0542	response to heat
CP978_RS18300	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP978_RS18315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP978_RS18320	COG0191	fructose-bisphosphate aldolase activity
CP978_RS18325	COG0477	Major facilitator Superfamily
CP978_RS18340	COG3844	kynureninase activity
CP978_RS18360	COG4585	Histidine kinase
CP978_RS18365	COG2197	response regulator
CP978_RS18370	COG2124	cytochrome p450
CP978_RS18375	COG3559	Exporter of polyketide antibiotics
CP978_RS18395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP978_RS18405	COG1802	Transcriptional regulator
CP978_RS18410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP978_RS18415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP978_RS18415	COG0515	serine threonine protein kinase
CP978_RS18420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CP978_RS18430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP978_RS18435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP978_RS18455	COG1595	DNA-templated transcription, initiation
CP978_RS18480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP978_RS18545	COG1408	metallophosphoesterase
CP978_RS18570	COG0003	Pfam Anion-transporting ATPase
CP978_RS18595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP978_RS18625	COG2267	carboxylic ester hydrolase activity
CP978_RS18635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP978_RS18640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP978_RS18700	COG1366	Belongs to the anti-sigma-factor antagonist family
CP978_RS18710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP978_RS18720	COG2264	protein methyltransferase activity
CP978_RS18730	COG1754	DNA topoisomerase type I activity
CP978_RS18730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP978_RS18735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP978_RS18770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP978_RS18770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP978_RS18795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP978_RS18800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP978_RS18805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP978_RS18810	COG0254	rRNA binding
CP978_RS18820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP978_RS18825	COG0346	lactoylglutathione lyase activity
CP978_RS18830	COG0640	Transcriptional regulator
CP978_RS18855	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS18860	COG0076	glutamate decarboxylase activity
CP978_RS18865	COG0789	Transcriptional regulator
CP978_RS18870	COG0586	Pfam SNARE associated Golgi protein
CP978_RS18880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP978_RS18885	COG2027	D-alanyl-D-alanine carboxypeptidase
CP978_RS18895	COG0037	tRNA processing
CP978_RS18900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CP978_RS18910	COG0302	gtp cyclohydrolase
CP978_RS18925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CP978_RS18940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP978_RS18940	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP978_RS18965	COG0649	NAD binding
CP978_RS18985	COG2197	response regulator
CP978_RS18990	COG1660	Displays ATPase and GTPase activities
CP978_RS19000	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CP978_RS19010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP978_RS19015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP978_RS19025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP978_RS19045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CP978_RS19065	COG0739	heme binding
CP978_RS19085	COG0346	lactoylglutathione lyase activity
CP978_RS19090	COG2205	protein histidine kinase activity
CP978_RS19095	COG0745	RESPONSE REGULATOR receiver
CP978_RS19105	COG1595	DNA-templated transcription, initiation
CP978_RS19120	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CP978_RS19140	COG0248	Ppx GppA phosphatase
CP978_RS19145	COG1082	Xylose isomerase domain protein TIM barrel
CP978_RS19150	COG1309	transcriptional regulator
CP978_RS19155	COG0129	dihydroxy-acid dehydratase activity
CP978_RS19165	COG4991	sh3 domain protein
CP978_RS19170	COG4991	sh3 domain protein
CP978_RS19185	COG1129	ABC transporter
CP978_RS19185	COG0842	Transport permease protein
CP978_RS19195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP978_RS19200	COG0180	Tryptophanyl-tRNA synthetase
CP978_RS19230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP978_RS19240	COG0123	including yeast histone deacetylase and acetoin utilization protein
CP978_RS19285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CP978_RS19290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CP978_RS19295	COG0181	hydroxymethylbilane synthase activity
CP978_RS19300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP978_RS19300	COG1648	precorrin-2 dehydrogenase activity
CP978_RS19305	COG0113	porphobilinogen synthase activity
CP978_RS19315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP978_RS19335	COG0018	arginyl-trna synthetase
CP978_RS19340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP978_RS19360	COG1690	Belongs to the RtcB family
CP978_RS19380	COG1742	UPF0060 membrane protein
CP978_RS19385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS19395	COG0745	RESPONSE REGULATOR receiver
CP978_RS19400	COG2205	protein histidine kinase activity
CP978_RS19420	COG1695	Transcriptional regulator
CP978_RS19435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP978_RS19440	COG0406	alpha-ribazole phosphatase activity
CP978_RS19455	COG0785	Cytochrome C biogenesis protein
CP978_RS19460	COG1333	cytochrome c biogenesis protein
CP978_RS19465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP978_RS19480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CP978_RS19490	COG0163	prenyltransferase activity
CP978_RS19500	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP978_RS19520	COG2124	cytochrome p450
CP978_RS19525	COG1278	Cold shock
CP978_RS19530	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP978_RS19545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP978_RS19555	COG2226	methyltransferase
CP978_RS19585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP978_RS19590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP978_RS19595	COG0649	NAD binding
CP978_RS19605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP978_RS19610	COG1034	ATP synthesis coupled electron transport
CP978_RS19615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP978_RS19620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP978_RS19630	COG0713	ATP synthesis coupled electron transport
CP978_RS19635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP978_RS19645	COG1007	ATP synthesis coupled electron transport
CP978_RS19655	COG0514	ATP-dependent DNA helicase (RecQ)
CP978_RS19670	COG0492	ferredoxin-NADP+ reductase activity
CP978_RS19675	COG0561	phosphatase activity
CP978_RS19680	COG3953	SLT domain
CP978_RS19680	COG5280	Phage tail tape measure protein TP901
CP978_RS19690	COG0142	geranyltranstransferase activity
CP978_RS19700	COG1131	(ABC) transporter
CP978_RS19725	COG0702	epimerase
CP978_RS19730	COG1733	regulation of RNA biosynthetic process
CP978_RS19735	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP978_RS19740	COG0674	pyruvate-flavodoxin oxidoreductase activity
CP978_RS19740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CP978_RS19760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP978_RS19765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP978_RS19770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP978_RS19775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP978_RS19780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP978_RS19785	COG0839	Belongs to the complex I subunit 6 family
CP978_RS19790	COG0713	ATP synthesis coupled electron transport
CP978_RS19795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP978_RS19805	COG1007	ATP synthesis coupled electron transport
CP978_RS19810	COG0501	Belongs to the peptidase M48B family
CP978_RS19815	COG3304	Inner membrane component domain
CP978_RS19825	COG2261	transglycosylase associated protein
CP978_RS19830	COG1666	GTP binding
CP978_RS19850	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS19865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP978_RS19870	COG2030	dehydratase
CP978_RS19880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP978_RS19890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP978_RS19895	COG0436	Aminotransferase
CP978_RS19910	COG0250	Participates in transcription elongation, termination and antitermination
CP978_RS19915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP978_RS19920	COG0081	regulation of translation
CP978_RS19935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CP978_RS19940	COG0222	ribosome binding
CP978_RS19950	COG0085	RNA polymerase activity
CP978_RS19955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP978_RS19985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP978_RS19990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP978_RS19995	COG0049	tRNA binding
CP978_RS20000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP978_RS20005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP978_RS20055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CP978_RS20105	COG0051	transcription antitermination factor activity, RNA binding
CP978_RS20110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP978_RS20115	COG0088	Forms part of the polypeptide exit tunnel
CP978_RS20120	COG0089	rRNA binding
CP978_RS20125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP978_RS20130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP978_RS20135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP978_RS20140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP978_RS20145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP978_RS20150	COG0255	Belongs to the universal ribosomal protein uL29 family
CP978_RS20155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP978_RS20160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP978_RS20165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP978_RS20170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP978_RS20175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP978_RS20185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP978_RS20190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP978_RS20195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP978_RS20200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP978_RS20205	COG1841	ribosomal large subunit assembly
CP978_RS20210	COG0200	Binds to the 23S rRNA
CP978_RS20220	COG0563	adenylate kinase activity
CP978_RS20230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP978_RS20235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP978_RS20240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP978_RS20245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP978_RS20250	COG0202	RNA polymerase activity
CP978_RS20255	COG0203	ribosomal protein L17
CP978_RS20260	COG0101	tRNA pseudouridine synthase activity
CP978_RS20270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP978_RS20275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP978_RS20280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP978_RS20285	COG1072	(Pantothenic acid kinase))
CP978_RS20295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP978_RS20305	COG0736	holo-[acyl-carrier-protein] synthase activity
CP978_RS20315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP978_RS20325	COG0802	atpase or kinase
CP978_RS20350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP978_RS20360	COG1609	Transcriptional regulator
CP978_RS20375	COG4941	Belongs to the sigma-70 factor family
CP978_RS20385	COG0726	polysaccharide deacetylase
CP978_RS20390	COG0726	polysaccharide deacetylase
CP978_RS20395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP978_RS20400	COG0459	protein refolding
CP978_RS20410	COG4221	oxidoreductase activity
CP978_RS20420	COG0583	DNA-binding transcription factor activity
CP978_RS20435	COG1595	DNA-templated transcription, initiation
CP978_RS20445	COG0516	GMP reductase activity
CP978_RS20455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP978_RS20470	COG0515	serine threonine protein kinase
CP978_RS20470	COG2815	serine threonine protein kinase
CP978_RS20475	COG0515	serine threonine protein kinase
CP978_RS20480	COG0515	serine threonine protein kinase
CP978_RS20480	COG2815	serine threonine protein kinase
CP978_RS20490	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS20510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP978_RS20510	COG0519	Catalyzes the synthesis of GMP from XMP
CP978_RS20550	COG2197	response regulator
CP978_RS20590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS20590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS20605	COG0714	Associated with various cellular activities
CP978_RS20615	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP978_RS20620	COG0045	succinate-CoA ligase (ADP-forming) activity
CP978_RS20650	COG0138	bifunctional purine biosynthesis protein purh
CP978_RS20660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP978_RS20675	COG0039	L-malate dehydrogenase activity
CP978_RS20685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP978_RS20690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP978_RS20695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP978_RS20705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP978_RS20710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP978_RS20720	COG0180	Tryptophanyl-tRNA synthetase
CP978_RS20740	COG1686	Belongs to the peptidase S11 family
CP978_RS20745	COG1408	metallophosphoesterase
CP978_RS20755	COG1285	pathogenesis
CP978_RS20760	COG2205	protein histidine kinase activity
CP978_RS20765	COG0745	RESPONSE REGULATOR receiver
CP978_RS20770	COG2409	Drug exporters of the RND superfamily
CP978_RS20785	COG1309	transcriptional regulator
CP978_RS20805	COG1053	succinate dehydrogenase
CP978_RS20815	COG2009	succinate dehydrogenase
CP978_RS20825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP978_RS20840	COG1595	DNA-templated transcription, initiation
CP978_RS20845	COG1595	DNA-templated transcription, initiation
CP978_RS20860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS20860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS20880	COG1216	Glycosyl transferase, family 2
CP978_RS20900	COG1216	Glycosyl transferase, family 2
CP978_RS20910	COG1083	cytidylyl-transferase
CP978_RS20915	COG2089	acid synthase
CP978_RS20925	COG0573	inorganic phosphate transmembrane transporter activity
CP978_RS20955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP978_RS20960	COG1473	amidohydrolase
CP978_RS20960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP978_RS20965	COG1744	ABC transporter substrate-binding protein PnrA-like
CP978_RS20975	COG1744	ABC transporter substrate-binding protein PnrA-like
CP978_RS20980	COG3845	ABC transporter
CP978_RS20990	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP978_RS21010	COG2972	Histidine kinase
CP978_RS21010	COG2205	protein histidine kinase activity
CP978_RS21030	COG2814	Major facilitator Superfamily
CP978_RS21035	COG0583	DNA-binding transcription factor activity
CP978_RS21045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP978_RS21070	COG2205	protein histidine kinase activity
CP978_RS21075	COG0745	RESPONSE REGULATOR receiver
CP978_RS21080	COG1595	DNA-templated transcription, initiation
CP978_RS21120	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS21125	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CP978_RS21180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP978_RS21190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP978_RS21215	COG4770	biotin carboxylase activity
CP978_RS21225	COG0424	maF-like protein
CP978_RS21240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP978_RS21250	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP978_RS21260	COG1024	Enoyl-CoA hydratase
CP978_RS21270	COG2986	histidine ammonia-lyase
CP978_RS21295	COG1136	(ABC) transporter
CP978_RS21305	COG1404	Belongs to the peptidase S8 family
CP978_RS21325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP978_RS21330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP978_RS21335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP978_RS21345	COG0501	Belongs to the peptidase M48B family
CP978_RS21370	COG2255	four-way junction helicase activity
CP978_RS21375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP978_RS21390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP978_RS21400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP978_RS21420	COG1331	Highly conserved protein containing a thioredoxin domain
CP978_RS21430	COG1309	transcriptional regulator
CP978_RS21435	COG0477	Major facilitator Superfamily
CP978_RS21445	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CP978_RS21475	COG0436	Aminotransferase
CP978_RS21485	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP978_RS21500	COG1414	Transcriptional regulator
CP978_RS21505	COG0251	oxidation-reduction process
CP978_RS21540	COG2894	cell division
CP978_RS21570	COG2197	response regulator
CP978_RS21590	COG2885	chlorophyll binding
CP978_RS21595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CP978_RS21615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP978_RS21625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CP978_RS21640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP978_RS21645	COG0450	alkyl hydroperoxide reductase
CP978_RS21660	COG1136	(ABC) transporter
CP978_RS21695	COG0114	fumarate hydratase activity
CP978_RS21700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CP978_RS21700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CP978_RS21725	COG1722	exodeoxyribonuclease VII activity
CP978_RS21730	COG1570	exodeoxyribonuclease VII activity
CP978_RS21735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP978_RS21750	COG0012	GTP binding
CP978_RS21780	COG0574	Belongs to the PEP-utilizing enzyme family
CP978_RS21780	COG3848	Pyruvate phosphate dikinase
CP978_RS21795	COG0642	Histidine kinase
CP978_RS21860	COG0534	Mate efflux family protein
CP978_RS21900	COG1217	gtp-binding protein TYPA
CP978_RS21905	COG4166	transmembrane transport
CP978_RS21910	COG0601	transmembrane transport
CP978_RS21915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS21925	COG4608	Belongs to the ABC transporter superfamily
CP978_RS21930	COG0346	lactoylglutathione lyase activity
CP978_RS21935	COG0519	Catalyzes the synthesis of GMP from XMP
CP978_RS21940	COG4608	Belongs to the ABC transporter superfamily
CP978_RS21950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS21955	COG0601	transmembrane transport
CP978_RS21960	COG0747	negative chemotaxis
CP978_RS21970	COG0601	transmembrane transport
CP978_RS21975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS21980	COG0444	Belongs to the ABC transporter superfamily
CP978_RS21985	COG4608	Belongs to the ABC transporter superfamily
CP978_RS22000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP978_RS22015	COG1131	(ABC) transporter
CP978_RS22025	COG4585	Histidine kinase
CP978_RS22030	COG2197	response regulator
CP978_RS22065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP978_RS22075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP978_RS22085	COG0519	Catalyzes the synthesis of GMP from XMP
CP978_RS22090	COG1024	Enoyl-CoA hydratase
CP978_RS22105	COG1595	DNA-templated transcription, initiation
CP978_RS22115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP978_RS22120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP978_RS22155	COG0598	Magnesium transport protein CorA
CP978_RS22165	COG2814	Major facilitator Superfamily
CP978_RS22180	COG2095	MarC family integral membrane protein
CP978_RS22190	COG1432	Conserved Protein
CP978_RS22200	COG0513	Belongs to the DEAD box helicase family
CP978_RS22240	COG0438	transferase activity, transferring glycosyl groups
CP978_RS22265	COG0513	Belongs to the DEAD box helicase family
CP978_RS22270	COG1278	Cold shock
CP978_RS22295	COG0210	DNA helicase
CP978_RS22300	COG0210	DNA helicase
CP978_RS22305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP978_RS22340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP978_RS22390	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP978_RS22400	COG1615	UPF0182 protein
CP978_RS22425	COG0753	catalase activity
CP978_RS22435	COG0483	inositol monophosphate 1-phosphatase activity
CP978_RS22445	COG2076	Multidrug Resistance protein
CP978_RS22450	COG1162	GTPase activity
CP978_RS22455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP978_RS22465	COG2135	peptidase activity
CP978_RS22475	COG1595	DNA-templated transcription, initiation
CP978_RS22480	COG5662	AntiSigma factor
CP978_RS22490	COG0242	peptide deformylase activity
CP978_RS22500	COG2124	cytochrome p450
CP978_RS22530	COG2188	Transcriptional regulator
CP978_RS22535	COG2182	Extracellular solute-binding protein
CP978_RS22540	COG1175	transmembrane transport
CP978_RS22545	COG0395	ABC-type sugar transport system, permease component
CP978_RS22550	COG1472	Belongs to the glycosyl hydrolase 3 family
CP978_RS22560	COG0363	glucosamine-6-phosphate deaminase activity
CP978_RS22575	COG1597	lipid kinase activity
CP978_RS22605	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CP978_RS22615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP978_RS22615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP978_RS22620	COG0142	geranyltranstransferase activity
CP978_RS22690	COG4106	trans-aconitate 2-methyltransferase activity
CP978_RS22710	COG0281	malic enzyme
CP978_RS22715	COG0604	alcohol dehydrogenase
CP978_RS22790	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP978_RS22790	COG0567	Dehydrogenase, E1 component
CP978_RS22795	COG2205	protein histidine kinase activity
CP978_RS22800	COG0745	RESPONSE REGULATOR receiver
CP978_RS22815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CP978_RS22830	COG2205	protein histidine kinase activity
CP978_RS22880	COG0768	penicillin binding
CP978_RS22890	COG2205	protein histidine kinase activity
CP978_RS22910	COG3285	dna ligase
CP978_RS22910	COG1793	dna ligase
CP978_RS22915	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP978_RS22940	COG0069	glutamate synthase activity
CP978_RS22950	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CP978_RS22950	COG1918	ferrous iron import across plasma membrane
CP978_RS23020	COG0018	arginyl-trna synthetase
CP978_RS23025	COG0019	diaminopimelate decarboxylase activity
CP978_RS23035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP978_RS23040	COG0083	homoserine kinase activity
CP978_RS23055	COG0254	rRNA binding
CP978_RS23060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP978_RS23065	COG2890	protein-(glutamine-N5) methyltransferase activity
CP978_RS23075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP978_RS23080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP978_RS23100	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP978_RS23105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP978_RS23110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP978_RS23115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP978_RS23120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP978_RS23125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP978_RS23130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP978_RS23145	COG2197	response regulator
CP978_RS23150	COG4585	Histidine kinase
CP978_RS23165	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP978_RS23180	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CP978_RS23225	COG0183	Belongs to the thiolase family
CP978_RS23290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS23290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS23325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CP978_RS23330	COG0857	belongs to the CobB CobQ family
CP978_RS23330	COG0280	phosphate acetyltransferase
CP978_RS23335	COG0205	6-phosphofructokinase activity
CP978_RS23340	COG4565	transcriptional regulatory protein
CP978_RS23345	COG3290	protein histidine kinase activity
CP978_RS23350	COG1301	dicarboxylic acid transport
CP978_RS23360	COG0477	Major facilitator Superfamily
CP978_RS23380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP978_RS23385	COG0366	Alpha amylase catalytic
CP978_RS23390	COG0366	Alpha amylase catalytic
CP978_RS23400	COG0058	SHG alpha-glucan phosphorylase activity
CP978_RS23420	COG1132	(ABC) transporter
CP978_RS23425	COG1132	(ABC) transporter
CP978_RS23435	COG1376	ErfK ybiS ycfS ynhG family protein
CP978_RS23440	COG1376	ErfK ybiS ycfS ynhG family protein
CP978_RS23455	COG0726	polysaccharide deacetylase
CP978_RS23490	COG4260	virion core protein, lumpy skin disease virus
CP978_RS23500	COG1760	l-serine dehydratase
CP978_RS23505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP978_RS23510	COG0509	glycine decarboxylation via glycine cleavage system
CP978_RS23515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP978_RS23535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS23540	COG0747	negative chemotaxis
CP978_RS23545	COG0601	transmembrane transport
CP978_RS23550	COG0444	Belongs to the ABC transporter superfamily
CP978_RS23555	COG4608	Belongs to the ABC transporter superfamily
CP978_RS23560	COG2860	membrane
CP978_RS23585	COG0482	sulfurtransferase activity
CP978_RS23600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP978_RS23615	COG1611	Belongs to the LOG family
CP978_RS23630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP978_RS23640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP978_RS23645	COG0154	amidase activity
CP978_RS23655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP978_RS23660	COG2409	Drug exporters of the RND superfamily
CP978_RS23665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP978_RS23680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP978_RS23680	COG1672	PFAM Archaeal ATPase
CP978_RS23690	COG2133	pyrroloquinoline quinone binding
CP978_RS23695	COG0667	Aldo Keto reductase
CP978_RS23710	COG5001	Diguanylate cyclase
CP978_RS23710	COG3300	MHYT domain
CP978_RS23720	COG0440	acetolactate synthase activity
CP978_RS23725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP978_RS23730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP978_RS23735	COG0477	Major facilitator Superfamily
CP978_RS23745	COG3835	regulator
CP978_RS23750	COG0506	proline dehydrogenase activity
CP978_RS23755	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS23765	COG0473	3-isopropylmalate dehydrogenase activity
CP978_RS23770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP978_RS23775	COG0832	Belongs to the urease beta subunit family
CP978_RS23775	COG0831	urea catabolic process
CP978_RS23780	COG0804	urea catabolic process
CP978_RS23785	COG2957	Belongs to the agmatine deiminase family
CP978_RS23795	COG3409	Peptidoglycan-binding domain 1 protein
CP978_RS23810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP978_RS23820	COG1472	Belongs to the glycosyl hydrolase 3 family
CP978_RS23830	COG2353	YceI-like domain
CP978_RS23835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP978_RS23855	COG2018	Roadblock/LC7 domain
CP978_RS23875	COG2018	Roadblock/LC7 domain
CP978_RS23890	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP978_RS23895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP978_RS23940	COG1414	Transcriptional regulator
CP978_RS23945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP978_RS23950	COG0066	3-isopropylmalate dehydratase activity
CP978_RS23960	COG0776	regulation of translation
CP978_RS23970	COG1920	GTP binding
CP978_RS23980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP978_RS23985	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP978_RS24005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP978_RS24010	COG1461	Dihydroxyacetone kinase
CP978_RS24020	COG0326	Molecular chaperone. Has ATPase activity
CP978_RS24030	COG0742	ribosomal rna small subunit methyltransferase
CP978_RS24035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP978_RS24050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CP978_RS24055	COG0571	ribonuclease III activity
CP978_RS24060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP978_RS24065	COG1733	regulation of RNA biosynthetic process
CP978_RS24070	COG2340	Cysteine-rich secretory protein family
CP978_RS24075	COG1254	Belongs to the acylphosphatase family
CP978_RS24095	COG0477	Major facilitator Superfamily
CP978_RS24125	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP978_RS24140	COG0442	prolyl-tRNA aminoacylation
CP978_RS24150	COG0228	four-way junction DNA binding
CP978_RS24155	COG1837	Belongs to the UPF0109 family
CP978_RS24160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP978_RS24165	COG0336	Belongs to the RNA methyltransferase TrmD family
CP978_RS24170	COG0335	large ribosomal subunit rRNA binding
CP978_RS24175	COG0681	Belongs to the peptidase S26 family
CP978_RS24205	COG0792	nuclease activity
CP978_RS24220	COG1191	sigma factor activity
CP978_RS24235	COG0052	Belongs to the universal ribosomal protein uS2 family
CP978_RS24240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP978_RS24245	COG0528	UMP kinase activity
CP978_RS24250	COG0233	cytoplasmic translational termination
CP978_RS24255	COG0575	Belongs to the CDS family
CP978_RS24260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP978_RS24270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CP978_RS24275	COG3842	ATPase activity
CP978_RS24295	COG1136	(ABC) transporter
CP978_RS24300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP978_RS24310	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS24360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP978_RS24375	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS24385	COG3842	ATPase activity
CP978_RS24390	COG1176	ABC-type spermidine putrescine transport system, permease component I
CP978_RS24395	COG1177	transmembrane transport
CP978_RS24400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP978_RS24420	COG2508	Transcriptional regulator
CP978_RS24440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP978_RS24455	COG2409	Drug exporters of the RND superfamily
CP978_RS24465	COG2197	response regulator
CP978_RS24470	COG1472	Belongs to the glycosyl hydrolase 3 family
CP978_RS24480	COG4209	transmembrane transport
CP978_RS24485	COG0395	ABC-type sugar transport system, permease component
CP978_RS24525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP978_RS24530	COG0750	zinc metalloprotease
CP978_RS24535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP978_RS24550	COG0442	prolyl-tRNA aminoacylation
CP978_RS24570	COG0779	Required for maturation of 30S ribosomal subunits
CP978_RS24585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP978_RS24595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP978_RS24600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP978_RS24610	COG0455	bacterial-type flagellum organization
CP978_RS24685	COG1404	Belongs to the peptidase S8 family
CP978_RS24700	COG1674	ftsk spoiiie
CP978_RS24715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP978_RS24720	COG1185	polyribonucleotide nucleotidyltransferase activity
CP978_RS24725	COG0612	Peptidase, M16
CP978_RS24730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP978_RS24750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CP978_RS24755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP978_RS24760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP978_RS24795	COG2208	phosphoserine phosphatase activity
CP978_RS24795	COG2770	Histidine kinase
CP978_RS24805	COG3437	response regulator, receiver
CP978_RS24805	COG4999	Histidine kinase
CP978_RS24805	COG3850	Histidine kinase
CP978_RS24805	COG2205	protein histidine kinase activity
CP978_RS24815	COG1674	ftsk spoiiie
CP978_RS24825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP978_RS24835	COG1058	Belongs to the CinA family
CP978_RS24835	COG1546	Belongs to the CinA family
CP978_RS24840	COG1396	sequence-specific DNA binding
CP978_RS24850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP978_RS24855	COG1201	RNA secondary structure unwinding
CP978_RS24860	COG1917	Cupin 2, conserved barrel domain protein
CP978_RS24860	COG2207	Transcriptional regulator
CP978_RS24925	COG0765	amino acid transport
CP978_RS24930	COG0765	amino acid transport
CP978_RS24935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP978_RS24940	COG1126	abc transporter atp-binding protein
CP978_RS24945	COG0745	RESPONSE REGULATOR receiver
CP978_RS24950	COG2205	protein histidine kinase activity
CP978_RS24955	COG2358	TRAP transporter, solute receptor (TAXI family
CP978_RS24970	COG0640	Transcriptional regulator
CP978_RS24975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP978_RS24980	COG1316	TRANSCRIPTIONal
CP978_RS25000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP978_RS25020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP978_RS25030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP978_RS25035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP978_RS25045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP978_RS25075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP978_RS25080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP978_RS25085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP978_RS25100	COG0588	phosphoglycerate mutase activity
CP978_RS25110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP978_RS25145	COG1126	abc transporter atp-binding protein
CP978_RS25150	COG1802	Transcriptional regulator
CP978_RS25155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP978_RS25170	COG0187	DNA topoisomerase II activity
CP978_RS25185	COG2197	response regulator
CP978_RS25195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP978_RS25200	COG4565	transcriptional regulatory protein
CP978_RS25210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP978_RS25220	COG4565	transcriptional regulatory protein
CP978_RS25225	COG3290	protein histidine kinase activity
CP978_RS25240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP978_RS25245	COG0612	Peptidase, M16
CP978_RS25260	COG1802	Transcriptional regulator
CP978_RS25265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP978_RS25290	COG1435	thymidine kinase activity
CP978_RS25320	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP978_RS25325	COG0483	inositol monophosphate 1-phosphatase activity
CP978_RS25330	COG0745	RESPONSE REGULATOR receiver
CP978_RS25335	COG2205	protein histidine kinase activity
CP978_RS25360	COG0756	dUTP diphosphatase activity
CP978_RS25395	COG0569	domain protein
CP978_RS25400	COG0531	amino acid
CP978_RS25405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP978_RS25455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP978_RS25460	COG1074	ATP-dependent DNA helicase activity
CP978_RS25525	COG1131	(ABC) transporter
CP978_RS25560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP978_RS25565	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CP978_RS25570	COG3971	2-oxopent-4-enoate hydratase activity
CP978_RS25590	COG1309	transcriptional regulator
CP978_RS25595	COG1414	Transcriptional regulator
CP978_RS25615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP978_RS25620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP978_RS25630	COG3209	COG3209 Rhs family protein
CP978_RS25665	COG1122	ATPase activity
CP978_RS25675	COG1309	transcriptional regulator
CP978_RS25685	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS25715	COG4608	Belongs to the ABC transporter superfamily
CP978_RS25720	COG0444	Belongs to the ABC transporter superfamily
CP978_RS25725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS25755	COG4115	mRNA cleavage
CP978_RS25760	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CP978_RS25765	COG0523	cobalamin synthesis protein
CP978_RS25810	COG1132	(ABC) transporter
CP978_RS25815	COG1119	ATPase activity
CP978_RS25830	COG0671	phosphoesterase, PA-phosphatase related
CP978_RS25835	COG0586	Pfam SNARE associated Golgi protein
CP978_RS25850	COG0725	ABC transporter, periplasmic molybdate-binding protein
CP978_RS25875	COG1799	cell septum assembly
CP978_RS25900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP978_RS25905	COG2235	arginine
CP978_RS25910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP978_RS25915	COG0531	amino acid
CP978_RS25925	COG1024	Enoyl-CoA hydratase
CP978_RS25980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP978_RS25985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP978_RS25990	COG2197	response regulator
CP978_RS26020	COG1653	transport
CP978_RS26025	COG1175	transmembrane transport
CP978_RS26030	COG0395	ABC-type sugar transport system, permease component
CP978_RS26035	COG1940	carbohydrate kinase activity
CP978_RS26040	COG4213	ABC transporter substrate-binding protein
CP978_RS26050	COG4214	carbohydrate transport
CP978_RS26055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP978_RS26060	COG0531	amino acid
CP978_RS26070	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP978_RS26070	COG1024	Enoyl-CoA hydratase
CP978_RS26075	COG0183	Belongs to the thiolase family
CP978_RS26080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP978_RS26095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP978_RS26110	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP978_RS26120	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP978_RS26125	COG3253	May function as heme-dependent peroxidase
CP978_RS26130	COG3220	belongs to the UPF0276 family
CP978_RS26145	COG0330	HflC and HflK could
CP978_RS26170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP978_RS26175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP978_RS26260	COG1174	glycine betaine transport
CP978_RS26280	COG2018	Roadblock/LC7 domain
CP978_RS26295	COG2986	histidine ammonia-lyase
CP978_RS26390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP978_RS26455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP978_RS26470	COG2197	response regulator
CP978_RS26475	COG4585	Histidine kinase
CP978_RS26490	COG1011	Hydrolase
CP978_RS26500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP978_RS26505	COG1116	anion transmembrane transporter activity
CP978_RS26530	COG0529	Catalyzes the synthesis of activated sulfate
CP978_RS26535	COG0175	sulfate reduction
CP978_RS26565	COG1960	acyl-CoA dehydrogenase activity
CP978_RS26595	COG1280	lysine exporter protein (LysE YggA)
CP978_RS26600	COG2040	homocysteine
CP978_RS26605	COG1309	transcriptional regulator
CP978_RS26615	COG0778	Nitroreductase
CP978_RS26625	COG0277	FAD linked oxidase domain protein
CP978_RS26635	COG5297	Belongs to the glycosyl hydrolase family 6
CP978_RS26640	COG1162	GTPase activity
CP978_RS26660	COG0028	Belongs to the TPP enzyme family
CP978_RS26680	COG1802	Transcriptional regulator
CP978_RS26690	COG3835	regulator
CP978_RS26735	COG2197	response regulator
CP978_RS26740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP978_RS26760	COG0406	alpha-ribazole phosphatase activity
CP978_RS26765	COG0436	Aminotransferase
CP978_RS26780	COG2304	oxidoreductase activity
CP978_RS26785	COG4264	IucA IucC family
CP978_RS26815	COG0673	inositol 2-dehydrogenase activity
CP978_RS26820	COG2188	Transcriptional regulator
CP978_RS26825	COG1940	carbohydrate kinase activity
CP978_RS26835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP978_RS26850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP978_RS26855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP978_RS26900	COG1674	ftsk spoiiie
CP978_RS26925	COG3629	intracellular signal transduction
CP978_RS26925	COG3903	Transcriptional regulator
CP978_RS26930	COG0405	Gamma-glutamyltransferase
CP978_RS26935	COG0542	response to heat
CP978_RS26955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP978_RS26960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP978_RS26965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS26970	COG1953	Uracil, thiamine, allantoin
CP978_RS27005	COG2234	aminopeptidase activity
CP978_RS27015	COG0483	inositol monophosphate 1-phosphatase activity
CP978_RS27025	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CP978_RS27065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP978_RS27085	COG1929	Belongs to the glycerate kinase type-1 family
CP978_RS27095	COG0688	phosphatidylethanolamine metabolic process
CP978_RS27100	COG1960	acyl-CoA dehydrogenase activity
CP978_RS27110	COG2301	Belongs to the HpcH HpaI aldolase family
CP978_RS27115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS27115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS27130	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP978_RS27145	COG0596	Alpha beta hydrolase
CP978_RS27170	COG1609	Transcriptional regulator
CP978_RS27175	COG0673	inositol 2-dehydrogenase activity
CP978_RS27185	COG2188	Transcriptional regulator
CP978_RS27190	COG3962	Belongs to the TPP enzyme family
CP978_RS27195	COG3718	enzyme involved in inositol metabolism
CP978_RS27205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP978_RS27230	COG0673	inositol 2-dehydrogenase activity
CP978_RS27235	COG2362	D-Aminopeptidase
CP978_RS27240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP978_RS27245	COG4946	Tricorn protease homolog
CP978_RS27245	COG0823	Involved in the tonB-independent uptake of proteins
CP978_RS27245	COG1506	peptidase
CP978_RS27250	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP978_RS27260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP978_RS27325	COG2226	methyltransferase
CP978_RS27330	COG0488	(ABC) transporter
CP978_RS27345	COG0693	protein deglycase activity
CP978_RS27355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CP978_RS27400	COG0443	Heat shock 70 kDa protein
CP978_RS27415	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP978_RS27420	COG2226	methyltransferase
CP978_RS27435	COG4733	cellulase activity
CP978_RS27435	COG5297	Belongs to the glycosyl hydrolase family 6
CP978_RS27445	COG5297	Belongs to the glycosyl hydrolase family 6
CP978_RS27455	COG0656	L-ascorbic acid biosynthetic process
CP978_RS27465	COG0477	Major facilitator Superfamily
CP978_RS27475	COG0745	RESPONSE REGULATOR receiver
CP978_RS27480	COG2205	protein histidine kinase activity
CP978_RS27485	COG0583	DNA-binding transcription factor activity
CP978_RS27495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP978_RS27500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP978_RS27505	COG1940	carbohydrate kinase activity
CP978_RS27510	COG1129	ABC transporter
CP978_RS27515	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP978_RS27525	COG0673	inositol 2-dehydrogenase activity
CP978_RS27585	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS27615	COG1414	Transcriptional regulator
CP978_RS27640	COG0515	serine threonine protein kinase
CP978_RS27640	COG2815	serine threonine protein kinase
CP978_RS27655	COG1136	(ABC) transporter
CP978_RS27720	COG0006	proline dipeptidase activity
CP978_RS27730	COG1609	Transcriptional regulator
CP978_RS27735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP978_RS27745	COG1175	transmembrane transport
CP978_RS27750	COG0395	ABC-type sugar transport system, permease component
CP978_RS27795	COG3864	Putative metallopeptidase domain
CP978_RS27805	COG0477	Major facilitator Superfamily
CP978_RS27810	COG1846	Transcriptional regulator
CP978_RS27860	COG1131	(ABC) transporter
CP978_RS27885	COG2268	Band 7 protein
CP978_RS27950	COG0433	COG0433 Predicted ATPase
CP978_RS27950	COG1674	ftsk spoiiie
CP978_RS27965	COG0584	glycerophosphoryl diester phosphodiesterase
CP978_RS27970	COG1609	Transcriptional regulator
CP978_RS27975	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP978_RS27980	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP978_RS27985	COG1129	ABC transporter
CP978_RS27990	COG1879	ABC-type sugar transport system periplasmic component
CP978_RS28010	COG2226	methyltransferase
CP978_RS28015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS28015	COG1703	isobutyryl-CoA mutase activity
CP978_RS28015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP978_RS28040	COG1175	transmembrane transport
CP978_RS28045	COG0395	ABC-type sugar transport system, permease component
CP978_RS28080	COG0531	amino acid
CP978_RS28095	COG1271	oxidase subunit
CP978_RS28115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP978_RS28135	COG1175	transmembrane transport
CP978_RS28140	COG0395	ABC-type sugar transport system, permease component
CP978_RS28150	COG0366	Alpha amylase catalytic
CP978_RS28155	COG2318	DinB family
CP978_RS28170	COG3973	AAA domain
CP978_RS28175	COG3340	Belongs to the peptidase S51 family
CP978_RS28190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CP978_RS28195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP978_RS28240	COG2124	cytochrome p450
CP978_RS28255	COG0114	fumarate hydratase activity
CP978_RS28275	COG0483	inositol monophosphate 1-phosphatase activity
CP978_RS28310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CP978_RS28385	COG2815	serine threonine protein kinase
CP978_RS28385	COG0515	serine threonine protein kinase
CP978_RS28395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP978_RS28470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP978_RS28475	COG0698	ribose 5-phosphate isomerase
CP978_RS28495	COG0297	glycogen (starch) synthase activity
CP978_RS28515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP978_RS28525	COG0477	Major facilitator Superfamily
CP978_RS28535	COG3467	pyridoxamine 5'-phosphate
CP978_RS28575	COG0181	hydroxymethylbilane synthase activity
CP978_RS28580	COG0438	transferase activity, transferring glycosyl groups
CP978_RS28590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP978_RS28610	COG0038	chloride channel
CP978_RS28625	COG1486	melibiose metabolic process
CP978_RS28635	COG3469	chitinase activity
CP978_RS28645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP978_RS28690	COG3842	ATPase activity
CP978_RS28695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CP978_RS28700	COG1176	ABC-type spermidine putrescine transport system, permease component I
CP978_RS28705	COG1177	transmembrane transport
CP978_RS28720	COG1175	transmembrane transport
CP978_RS28725	COG0395	ABC-type sugar transport system, permease component
CP978_RS28730	COG0366	Alpha amylase catalytic
CP978_RS28760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP978_RS28765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP978_RS28770	COG3485	protocatechuate 3,4-dioxygenase
CP978_RS28775	COG3485	protocatechuate 3,4-dioxygenase
CP978_RS28780	COG1846	Transcriptional regulator
CP978_RS28785	COG1793	dna ligase
CP978_RS28850	COG1515	deoxyribonuclease V activity
CP978_RS28855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP978_RS28860	COG0183	Belongs to the thiolase family
CP978_RS28865	COG1024	Enoyl-CoA hydratase
CP978_RS28865	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP978_RS28870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP978_RS28900	COG2183	response to ionizing radiation
CP978_RS28910	COG1024	Enoyl-CoA hydratase
CP978_RS28920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP978_RS28960	COG1134	teichoic acid transport
CP978_RS28960	COG1388	LysM domain
CP978_RS28965	COG1562	ergosterol biosynthetic process
CP978_RS28975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP978_RS28985	COG1657	PFAM Prenyltransferase squalene oxidase
CP978_RS29000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP978_RS29005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP978_RS29025	COG2365	Tyrosine phosphatase family
CP978_RS29035	COG2755	lipolytic protein G-D-S-L family
CP978_RS29070	COG4106	trans-aconitate 2-methyltransferase activity
CP978_RS29120	COG0493	'glutamate synthase
CP978_RS29120	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CP978_RS29130	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS29135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CP978_RS29140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CP978_RS29145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP978_RS29150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP978_RS29180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP978_RS29185	COG2124	cytochrome p450
CP978_RS29300	COG1309	transcriptional regulator
CP978_RS29340	COG0583	DNA-binding transcription factor activity
CP978_RS29435	COG0583	DNA-binding transcription factor activity
CP978_RS29440	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS29470	COG1408	metallophosphoesterase
CP978_RS29510	COG1132	(ABC) transporter
CP978_RS29515	COG1846	Transcriptional regulator
CP978_RS29540	COG0601	transmembrane transport
CP978_RS29550	COG0444	Belongs to the ABC transporter superfamily
CP978_RS29560	COG4166	transmembrane transport
CP978_RS29570	COG1136	(ABC) transporter
CP978_RS29585	COG1063	alcohol dehydrogenase
CP978_RS29590	COG0156	8-amino-7-oxononanoate synthase activity
CP978_RS29595	COG0583	DNA-binding transcription factor activity
CP978_RS29615	COG2770	Histidine kinase
CP978_RS29615	COG2208	phosphoserine phosphatase activity
CP978_RS29665	COG0745	RESPONSE REGULATOR receiver
CP978_RS29695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP978_RS29765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP978_RS29785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP978_RS29830	COG5002	protein histidine kinase activity
CP978_RS29850	COG1136	(ABC) transporter
CP978_RS29850	COG0577	efflux transmembrane transporter activity
CP978_RS29855	COG1136	(ABC) transporter
CP978_RS29855	COG0577	efflux transmembrane transporter activity
CP978_RS29890	COG0601	transmembrane transport
CP978_RS29895	COG4171	peptide transport system, permease
CP978_RS29900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP978_RS29905	COG1021	2,3-dihydroxybenzoate-AMP ligase
CP978_RS29915	COG3433	isochorismatase activity
CP978_RS29915	COG2226	methyltransferase
CP978_RS29915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP978_RS29930	COG2124	cytochrome p450
CP978_RS29945	COG2375	cellular response to nickel ion
CP978_RS29945	COG1132	(ABC) transporter
CP978_RS29950	COG1132	(ABC) transporter
CP978_RS29960	COG2813	Specifically methylates the guanine in position
CP978_RS30005	COG2124	cytochrome p450
CP978_RS30010	COG2124	cytochrome p450
CP978_RS30020	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS30040	COG0444	Belongs to the ABC transporter superfamily
CP978_RS30050	COG0601	transmembrane transport
CP978_RS30060	COG1609	Transcriptional regulator
CP978_RS30105	COG0559	Belongs to the binding-protein-dependent transport system permease family
CP978_RS30130	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS30135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS30145	COG0601	transmembrane transport
CP978_RS30150	COG0444	Belongs to the ABC transporter superfamily
CP978_RS30155	COG4608	Belongs to the ABC transporter superfamily
CP978_RS30160	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS30165	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS30180	COG4176	ABC-type proline glycine betaine transport system permease component
CP978_RS30185	COG0517	IMP dehydrogenase activity
CP978_RS30185	COG4175	Glycine betaine
CP978_RS30195	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS30200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CP978_RS30210	COG0351	phosphomethylpyrimidine kinase
CP978_RS30305	COG0604	alcohol dehydrogenase
CP978_RS30330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP978_RS30340	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CP978_RS30350	COG0174	glutamine synthetase
CP978_RS30450	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS30470	COG2208	phosphoserine phosphatase activity
CP978_RS30470	COG2172	sigma factor antagonist activity
CP978_RS30470	COG1366	Belongs to the anti-sigma-factor antagonist family
CP978_RS30500	COG3800	Transcriptional regulator
CP978_RS30500	COG1396	sequence-specific DNA binding
CP978_RS30515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CP978_RS30525	COG1116	anion transmembrane transporter activity
CP978_RS30580	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS30670	COG1222	aaa ATPase
CP978_RS30700	COG1051	belongs to the nudix hydrolase family
CP978_RS30715	COG1136	(ABC) transporter
CP978_RS30750	COG0583	DNA-binding transcription factor activity
CP978_RS30760	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS30765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP978_RS30775	COG1051	belongs to the nudix hydrolase family
CP978_RS30790	COG3226	Transcriptional regulator
CP978_RS30820	COG0187	DNA topoisomerase II activity
CP978_RS30830	COG0667	Aldo Keto reductase
CP978_RS30855	COG4413	Urea transporter
CP978_RS30860	COG0831	urea catabolic process
CP978_RS30865	COG0832	Belongs to the urease beta subunit family
CP978_RS30865	COG0831	urea catabolic process
CP978_RS30870	COG0804	urea catabolic process
CP978_RS30875	COG0830	nickel cation binding
CP978_RS30880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP978_RS30885	COG0829	nickel cation binding
CP978_RS30915	COG1175	transmembrane transport
CP978_RS30920	COG0395	ABC-type sugar transport system, permease component
CP978_RS30930	COG1131	(ABC) transporter
CP978_RS30955	COG3629	intracellular signal transduction
CP978_RS30955	COG3903	Transcriptional regulator
CP978_RS30995	COG1309	transcriptional regulator
CP978_RS31020	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS31050	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS31070	COG1070	Carbohydrate kinase
CP978_RS31110	COG2018	Roadblock/LC7 domain
CP978_RS31115	COG1946	Acyl-CoA thioesterase
CP978_RS31135	COG1132	(ABC) transporter
CP978_RS31155	COG1132	(ABC) transporter
CP978_RS31185	COG1116	anion transmembrane transporter activity
CP978_RS31190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP978_RS31195	COG0432	Pfam Uncharacterised protein family UPF0047
CP978_RS31210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP978_RS31280	COG2706	6-phosphogluconolactonase activity
CP978_RS31290	COG2971	BadF BadG BcrA BcrD
CP978_RS31295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP978_RS31300	COG1937	Protein conserved in bacteria
CP978_RS31315	COG1309	transcriptional regulator
CP978_RS31355	COG0584	glycerophosphoryl diester phosphodiesterase
CP978_RS31385	COG0204	Acyl-transferase
CP978_RS31400	COG2086	electron transfer activity
CP978_RS31405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP978_RS31445	COG2304	oxidoreductase activity
CP978_RS31470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP978_RS31480	COG1660	Displays ATPase and GTPase activities
CP978_RS31495	COG0445	tRNA wobble uridine modification
CP978_RS31510	COG4585	Histidine kinase
CP978_RS31515	COG2197	response regulator
CP978_RS31530	COG4977	sequence-specific DNA binding
CP978_RS31535	COG3387	PFAM Glycoside hydrolase 15-related
CP978_RS31540	COG1349	DNA-binding transcription factor activity
CP978_RS31545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP978_RS31555	COG2813	Specifically methylates the guanine in position
CP978_RS31565	COG1940	carbohydrate kinase activity
CP978_RS31600	COG1349	DNA-binding transcription factor activity
CP978_RS31630	COG0463	Glycosyl transferase, family 2
CP978_RS31655	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS31680	COG0778	Nitroreductase
CP978_RS31710	COG3845	ABC transporter
CP978_RS31750	COG0301	tRNA thio-modification
CP978_RS31755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CP978_RS31780	COG0174	glutamine synthetase
CP978_RS31820	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP978_RS31830	COG2837	iron assimilation
CP978_RS31845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP978_RS31850	COG1993	acr, cog1993
CP978_RS31855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP978_RS31860	COG1968	undecaprenyl-diphosphatase activity
CP978_RS31865	COG2188	Transcriptional regulator
CP978_RS31870	COG1113	amino acid transport
CP978_RS31880	COG1027	Aspartate ammonia-lyase
CP978_RS31885	COG2066	Belongs to the glutaminase family
CP978_RS31895	COG1686	Belongs to the peptidase S11 family
CP978_RS31900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CP978_RS31905	COG2226	methyltransferase
CP978_RS31910	COG3458	cephalosporin-C deacetylase activity
CP978_RS31925	COG2890	protein-(glutamine-N5) methyltransferase activity
CP978_RS31940	COG1461	Dihydroxyacetone kinase
CP978_RS31945	COG2376	Dihydroxyacetone kinase
CP978_RS31975	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS32020	COG3851	Histidine kinase
CP978_RS32025	COG2197	response regulator
CP978_RS32035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP978_RS32055	COG0318	PFAM AMP-dependent synthetase and ligase
CP978_RS32070	COG2018	Roadblock/LC7 domain
CP978_RS32080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP978_RS32095	COG2203	Gaf domain
CP978_RS32095	COG2199	diguanylate cyclase activity
CP978_RS32135	COG0367	asparagine synthase
CP978_RS32175	COG0754	glutathionylspermidine amidase activity
CP978_RS32215	COG0671	phosphoesterase, PA-phosphatase related
CP978_RS32230	COG0346	lactoylglutathione lyase activity
CP978_RS32235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP978_RS32245	COG0583	DNA-binding transcription factor activity
CP978_RS32250	COG0667	Aldo Keto reductase
CP978_RS32255	COG0542	response to heat
CP978_RS32275	COG0740	serine-type endopeptidase activity
CP978_RS32280	COG0740	serine-type endopeptidase activity
CP978_RS32290	COG3507	Belongs to the glycosyl hydrolase 43 family
CP978_RS32330	COG0488	(ABC) transporter
CP978_RS32370	COG2814	Major facilitator Superfamily
CP978_RS32375	COG1846	Transcriptional regulator
CP978_RS32390	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS32395	COG0667	Aldo Keto reductase
CP978_RS32400	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS32410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP978_RS32410	COG0463	Glycosyl transferase, family 2
CP978_RS32415	COG0438	transferase activity, transferring glycosyl groups
CP978_RS32420	COG2182	Extracellular solute-binding protein
CP978_RS32425	COG1175	transmembrane transport
CP978_RS32430	COG0395	ABC-type sugar transport system, permease component
CP978_RS32435	COG2723	6-phospho-beta-galactosidase activity
CP978_RS32445	COG0745	RESPONSE REGULATOR receiver
CP978_RS32450	COG2205	protein histidine kinase activity
CP978_RS32455	COG1376	ErfK ybiS ycfS ynhG family protein
CP978_RS32475	COG0701	Predicted permease
CP978_RS32560	COG2837	iron assimilation
CP978_RS32575	COG1131	(ABC) transporter
CP978_RS32580	COG2124	cytochrome p450
CP978_RS32610	COG2326	polyphosphate kinase activity
CP978_RS32670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP978_RS32675	COG0095	Lipoate-protein ligase
CP978_RS32710	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP978_RS32715	COG0714	Associated with various cellular activities
CP978_RS32740	COG0667	Aldo Keto reductase
CP978_RS32795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP978_RS32795	COG1017	nitric oxide dioxygenase activity
CP978_RS32805	COG0596	Alpha beta hydrolase
CP978_RS32845	COG1120	ATPase activity
CP978_RS32850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS32855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP978_RS32870	COG5398	heme oxygenase
CP978_RS32885	COG2814	Major facilitator Superfamily
CP978_RS32950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP978_RS32960	COG0531	amino acid
CP978_RS32965	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CP978_RS32975	COG0726	polysaccharide deacetylase
CP978_RS32980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP978_RS32985	COG0477	Major facilitator Superfamily
CP978_RS32995	COG1522	sequence-specific DNA binding
CP978_RS33005	COG0235	Class ii aldolase
CP978_RS33010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP978_RS33015	COG0477	Major facilitator Superfamily
CP978_RS33020	COG0135	phosphoribosylanthranilate isomerase activity
CP978_RS33025	COG2313	pseudouridylate synthase activity
CP978_RS33050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP978_RS33055	COG2151	metal-sulfur cluster biosynthetic enzyme
CP978_RS33060	COG3396	Phenylacetate-CoA oxygenase
CP978_RS33065	COG3460	Phenylacetate-CoA oxygenase
CP978_RS33070	COG3396	Phenylacetate-CoA oxygenase
CP978_RS33075	COG1024	Enoyl-CoA hydratase
CP978_RS33080	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP978_RS33090	COG0183	Belongs to the thiolase family
CP978_RS33095	COG1012	belongs to the aldehyde dehydrogenase family
CP978_RS33100	COG2050	protein possibly involved in aromatic compounds catabolism
CP978_RS33115	COG2318	DinB family
CP978_RS33165	COG2329	Antibiotic biosynthesis monooxygenase
CP978_RS33175	COG0251	oxidation-reduction process
CP978_RS33225	COG0745	RESPONSE REGULATOR receiver
CP978_RS33230	COG2205	protein histidine kinase activity
CP978_RS33235	COG0039	L-malate dehydrogenase activity
CP978_RS33255	COG1510	regulation of RNA biosynthetic process
CP978_RS33260	COG1120	ATPase activity
CP978_RS33265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS33270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS33305	COG1595	DNA-templated transcription, initiation
CP978_RS33310	COG1252	NADH dehydrogenase
CP978_RS33335	COG0785	Cytochrome C biogenesis protein
CP978_RS33340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP978_RS33340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CP978_RS33355	COG0702	epimerase
CP978_RS33365	COG0242	peptide deformylase activity
CP978_RS33385	COG1902	pentaerythritol trinitrate reductase activity
CP978_RS33405	COG1683	Conserved Protein
CP978_RS33435	COG2197	response regulator
CP978_RS33450	COG0667	Aldo Keto reductase
CP978_RS33465	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS33475	COG0667	Aldo Keto reductase
CP978_RS33505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP978_RS33510	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS33515	COG0022	dehydrogenase e1 component
CP978_RS33520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CP978_RS33535	COG3386	PFAM SMP-30 Gluconolaconase
CP978_RS33540	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS33555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP978_RS33555	COG1116	anion transmembrane transporter activity
CP978_RS33575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP978_RS33575	COG2755	lipolytic protein G-D-S-L family
CP978_RS33580	COG2205	protein histidine kinase activity
CP978_RS33585	COG0745	RESPONSE REGULATOR receiver
CP978_RS33630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CP978_RS33635	COG1733	regulation of RNA biosynthetic process
CP978_RS33660	COG4249	Peptidase C14 caspase catalytic subunit p20
CP978_RS33660	COG2319	Wd-40 repeat
CP978_RS33705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP978_RS33750	COG1309	transcriptional regulator
CP978_RS33755	COG0477	Major facilitator Superfamily
CP978_RS33785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP978_RS33790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP978_RS33795	COG2175	clavaminate synthase activity
CP978_RS33805	COG0789	Transcriptional regulator
CP978_RS33810	COG0596	Alpha beta hydrolase
CP978_RS33815	COG3321	synthase
CP978_RS33815	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS33815	COG0604	alcohol dehydrogenase
CP978_RS33835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CP978_RS33855	COG1136	(ABC) transporter
CP978_RS33855	COG0577	efflux transmembrane transporter activity
CP978_RS33900	COG1940	carbohydrate kinase activity
CP978_RS33910	COG3142	Participates in the control of copper homeostasis
CP978_RS33935	COG2132	Multicopper oxidase
CP978_RS33940	COG0535	radical SAM domain protein
CP978_RS33955	COG1140	nitrate reductase beta subunit
CP978_RS34030	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS34040	COG0768	penicillin binding
CP978_RS34055	COG1414	Transcriptional regulator
CP978_RS34060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP978_RS34085	COG0402	S-adenosylhomocysteine deaminase activity
CP978_RS34130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP978_RS34160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP978_RS34165	COG0747	negative chemotaxis
CP978_RS34180	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP978_RS34185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS34190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP978_RS34195	COG1120	ATPase activity
CP978_RS34200	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CP978_RS34205	COG1132	(ABC) transporter
CP978_RS34215	COG1132	(ABC) transporter
CP978_RS34240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP978_RS34265	COG0431	NADPH-dependent FMN reductase
CP978_RS34275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP978_RS34290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP978_RS34295	COG0519	Catalyzes the synthesis of GMP from XMP
CP978_RS34295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP978_RS34300	COG0659	secondary active sulfate transmembrane transporter activity
CP978_RS34320	COG4335	DNA alkylation repair
CP978_RS34330	COG1959	2 iron, 2 sulfur cluster binding
CP978_RS34335	COG1404	Belongs to the peptidase S8 family
CP978_RS34360	COG1733	regulation of RNA biosynthetic process
CP978_RS34380	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS34385	COG2801	Transposase and inactivated derivatives
CP978_RS34395	COG4221	oxidoreductase activity
CP978_RS34400	COG1309	transcriptional regulator
CP978_RS34405	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS34410	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS34415	COG1028	Short-chain dehydrogenase reductase Sdr
CP978_RS34425	COG1595	DNA-templated transcription, initiation
CP978_RS34455	COG2197	response regulator
CP978_RS34460	COG4585	Histidine kinase
CP978_RS34465	COG1131	(ABC) transporter
CP978_RS34480	COG0367	asparagine synthase
CP978_RS34520	COG2197	response regulator
CP978_RS34565	COG0583	DNA-binding transcription factor activity
CP978_RS34585	COG4865	methylaspartate mutase activity
CP978_RS34610	COG0492	ferredoxin-NADP+ reductase activity