locus-tag	class	description
JYK04_RS00070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS00255	COG2197	response regulator
JYK04_RS00260	COG4585	Histidine kinase
JYK04_RS00295	COG2124	cytochrome p450
JYK04_RS00330	COG2124	cytochrome p450
JYK04_RS00350	COG1695	Transcriptional regulator
JYK04_RS00370	COG2226	methyltransferase
JYK04_RS00410	COG0222	ribosome binding
JYK04_RS00455	COG4221	oxidoreductase activity
JYK04_RS00655	COG1309	transcriptional regulator
JYK04_RS00660	COG0488	(ABC) transporter
JYK04_RS00665	COG4257	antibiotic catabolic process
JYK04_RS00740	COG2197	response regulator
JYK04_RS00775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS00780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS00785	COG0477	Major facilitator Superfamily
JYK04_RS00825	COG0604	alcohol dehydrogenase
JYK04_RS00825	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS00825	COG3321	synthase
JYK04_RS00830	COG0583	DNA-binding transcription factor activity
JYK04_RS00870	COG2319	Wd-40 repeat
JYK04_RS00870	COG4249	Peptidase C14 caspase catalytic subunit p20
JYK04_RS00885	COG3655	Transcriptional regulator
JYK04_RS00955	COG0431	NADPH-dependent FMN reductase
JYK04_RS01135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JYK04_RS01365	COG0740	serine-type endopeptidase activity
JYK04_RS01370	COG0740	serine-type endopeptidase activity
JYK04_RS01460	COG1742	UPF0060 membrane protein
JYK04_RS01500	COG5492	domain, Protein
JYK04_RS01500	COG4932	domain protein
JYK04_RS01535	COG0640	Transcriptional regulator
JYK04_RS01555	COG2264	protein methyltransferase activity
JYK04_RS01560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JYK04_RS01665	COG3293	Transposase
JYK04_RS01795	COG0539	negative regulation of cytoplasmic translation
JYK04_RS01805	COG2045	Belongs to the ComB family
JYK04_RS01870	COG2197	response regulator
JYK04_RS01875	COG4585	Histidine kinase
JYK04_RS01885	COG0702	epimerase
JYK04_RS01890	COG1733	regulation of RNA biosynthetic process
JYK04_RS01925	COG3387	PFAM Glycoside hydrolase 15-related
JYK04_RS01930	COG1309	transcriptional regulator
JYK04_RS01980	COG1733	regulation of RNA biosynthetic process
JYK04_RS02020	COG0076	glutamate decarboxylase activity
JYK04_RS02060	COG0667	Aldo Keto reductase
JYK04_RS02070	COG1278	Cold shock
JYK04_RS02130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JYK04_RS02155	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JYK04_RS02165	COG0583	DNA-binding transcription factor activity
JYK04_RS02170	COG0402	S-adenosylhomocysteine deaminase activity
JYK04_RS02220	COG1073	alpha beta
JYK04_RS02225	COG3835	regulator
JYK04_RS02285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JYK04_RS02290	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS02320	COG4585	Histidine kinase
JYK04_RS02405	COG0513	Belongs to the DEAD box helicase family
JYK04_RS02410	COG1278	Cold shock
JYK04_RS02420	COG3250	beta-galactosidase activity
JYK04_RS02455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JYK04_RS02520	COG1136	(ABC) transporter
JYK04_RS02530	COG1653	transport
JYK04_RS02535	COG0366	Alpha amylase catalytic
JYK04_RS02540	COG1653	transport
JYK04_RS02545	COG1175	transmembrane transport
JYK04_RS02550	COG0395	ABC-type sugar transport system, permease component
JYK04_RS02555	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JYK04_RS02575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JYK04_RS02585	COG3896	Chloramphenicol phosphotransferase-like protein
JYK04_RS02605	COG0702	epimerase
JYK04_RS02670	COG4977	sequence-specific DNA binding
JYK04_RS02680	COG0477	Major facilitator Superfamily
JYK04_RS02770	COG2124	cytochrome p450
JYK04_RS02785	COG0181	hydroxymethylbilane synthase activity
JYK04_RS02790	COG2815	serine threonine protein kinase
JYK04_RS02790	COG0515	serine threonine protein kinase
JYK04_RS02800	COG0739	heme binding
JYK04_RS02820	COG0300	oxidoreductase activity
JYK04_RS02830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS02860	COG3485	protocatechuate 3,4-dioxygenase
JYK04_RS02885	COG1191	sigma factor activity
JYK04_RS02920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JYK04_RS03035	COG2318	DinB family
JYK04_RS03065	COG1191	sigma factor activity
JYK04_RS03080	COG0475	glutathione-regulated potassium exporter activity
JYK04_RS03110	COG1191	sigma factor activity
JYK04_RS03130	COG0667	Aldo Keto reductase
JYK04_RS03145	COG1619	proteins homologs of microcin C7 resistance protein MccF
JYK04_RS03155	COG2211	Major facilitator Superfamily
JYK04_RS03165	COG2318	DinB family
JYK04_RS03170	COG0596	Alpha beta hydrolase
JYK04_RS03310	COG1011	Hydrolase
JYK04_RS03365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JYK04_RS03375	COG0028	Belongs to the TPP enzyme family
JYK04_RS03380	COG0069	glutamate synthase activity
JYK04_RS03395	COG2045	Belongs to the ComB family
JYK04_RS03420	COG2267	carboxylic ester hydrolase activity
JYK04_RS03425	COG3226	Transcriptional regulator
JYK04_RS03435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JYK04_RS03435	COG2755	lipolytic protein G-D-S-L family
JYK04_RS03480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JYK04_RS03485	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JYK04_RS03515	COG0789	Transcriptional regulator
JYK04_RS03560	COG3629	intracellular signal transduction
JYK04_RS03560	COG3903	Transcriptional regulator
JYK04_RS03595	COG0515	serine threonine protein kinase
JYK04_RS03615	COG0617	tRNA 3'-terminal CCA addition
JYK04_RS03640	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JYK04_RS03700	COG3415	Transposase
JYK04_RS03700	COG2801	Transposase and inactivated derivatives
JYK04_RS03720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JYK04_RS03785	COG3629	intracellular signal transduction
JYK04_RS03785	COG3903	Transcriptional regulator
JYK04_RS03795	COG2205	protein histidine kinase activity
JYK04_RS03800	COG0745	RESPONSE REGULATOR receiver
JYK04_RS03810	COG0785	Cytochrome C biogenesis protein
JYK04_RS03815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JYK04_RS03830	COG2340	Cysteine-rich secretory protein family
JYK04_RS03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JYK04_RS03875	COG2015	COG2015, Alkyl sulfatase and related hydrolases
JYK04_RS03880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JYK04_RS03915	COG0745	RESPONSE REGULATOR receiver
JYK04_RS03920	COG0642	Histidine kinase
JYK04_RS03930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JYK04_RS03950	COG0456	acetyltransferase
JYK04_RS03960	COG0583	DNA-binding transcription factor activity
JYK04_RS03975	COG4044	May play a role in the intracellular transport of hydrophobic ligands
JYK04_RS03985	COG0475	glutathione-regulated potassium exporter activity
JYK04_RS03995	COG1595	DNA-templated transcription, initiation
JYK04_RS04000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS04030	COG0604	alcohol dehydrogenase
JYK04_RS04035	COG1476	TRANSCRIPTIONal
JYK04_RS04045	COG2135	peptidase activity
JYK04_RS04065	COG1366	Belongs to the anti-sigma-factor antagonist family
JYK04_RS04070	COG1191	sigma factor activity
JYK04_RS04080	COG0784	Response regulator, receiver
JYK04_RS04085	COG4251	negative regulation of phosphorylation
JYK04_RS04090	COG0745	RESPONSE REGULATOR receiver
JYK04_RS04095	COG1252	NADH dehydrogenase
JYK04_RS04150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JYK04_RS04160	COG2261	transglycosylase associated protein
JYK04_RS04205	COG0753	catalase activity
JYK04_RS04205	COG0693	protein deglycase activity
JYK04_RS04255	COG0745	RESPONSE REGULATOR receiver
JYK04_RS04270	COG1136	(ABC) transporter
JYK04_RS04275	COG1136	(ABC) transporter
JYK04_RS04285	COG2205	protein histidine kinase activity
JYK04_RS04290	COG0672	)-iron permease
JYK04_RS04295	COG2837	iron assimilation
JYK04_RS04305	COG0671	phosphoesterase, PA-phosphatase related
JYK04_RS04310	COG0671	phosphoesterase, PA-phosphatase related
JYK04_RS04315	COG0586	Pfam SNARE associated Golgi protein
JYK04_RS04345	COG4171	peptide transport system, permease
JYK04_RS04350	COG0601	transmembrane transport
JYK04_RS04365	COG3293	Transposase
JYK04_RS04380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JYK04_RS04410	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JYK04_RS04490	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JYK04_RS04550	COG1846	Transcriptional regulator
JYK04_RS04565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JYK04_RS04580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS04585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JYK04_RS04590	COG3878	Protein conserved in bacteria
JYK04_RS04605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JYK04_RS04610	COG0477	Major facilitator Superfamily
JYK04_RS04625	COG1725	Transcriptional regulator
JYK04_RS04640	COG2124	cytochrome p450
JYK04_RS04660	COG1428	Deoxynucleoside kinase
JYK04_RS04700	COG1957	nucleoside hydrolase
JYK04_RS04725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JYK04_RS04775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JYK04_RS04810	COG1309	transcriptional regulator
JYK04_RS04815	COG0300	oxidoreductase activity
JYK04_RS04895	COG2124	cytochrome p450
JYK04_RS04935	COG0531	amino acid
JYK04_RS04950	COG0702	epimerase
JYK04_RS04980	COG0300	oxidoreductase activity
JYK04_RS05005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS05015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JYK04_RS05025	COG1982	Orn Lys Arg decarboxylase major
JYK04_RS05060	COG0477	Major facilitator Superfamily
JYK04_RS05070	COG3973	AAA domain
JYK04_RS05105	COG0745	RESPONSE REGULATOR receiver
JYK04_RS05110	COG5002	protein histidine kinase activity
JYK04_RS05130	COG1733	regulation of RNA biosynthetic process
JYK04_RS05150	COG0583	DNA-binding transcription factor activity
JYK04_RS05185	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS05195	COG1376	ErfK ybiS ycfS ynhG family protein
JYK04_RS05240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JYK04_RS05245	COG1505	serine-type exopeptidase activity
JYK04_RS05280	COG4989	oxidoreductase activity
JYK04_RS05295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYK04_RS05305	COG4585	Histidine kinase
JYK04_RS05310	COG2197	response regulator
JYK04_RS05370	COG0667	Aldo Keto reductase
JYK04_RS05405	COG0431	NADPH-dependent FMN reductase
JYK04_RS05420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JYK04_RS05475	COG1846	Transcriptional regulator
JYK04_RS05545	COG1404	Belongs to the peptidase S8 family
JYK04_RS05560	COG0187	DNA topoisomerase II activity
JYK04_RS05610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JYK04_RS05615	COG3473	Maleate cis-trans isomerase
JYK04_RS05620	COG0179	Fumarylacetoacetate (FAA) hydrolase
JYK04_RS05650	COG0657	acetylesterase activity
JYK04_RS05670	COG1609	Transcriptional regulator
JYK04_RS05695	COG2272	Belongs to the type-B carboxylesterase lipase family
JYK04_RS05725	COG3842	ATPase activity
JYK04_RS05745	COG2188	Transcriptional regulator
JYK04_RS05755	COG0583	DNA-binding transcription factor activity
JYK04_RS05760	COG2197	response regulator
JYK04_RS05765	COG4585	Histidine kinase
JYK04_RS05770	COG1136	(ABC) transporter
JYK04_RS05775	COG0577	efflux transmembrane transporter activity
JYK04_RS05775	COG1136	(ABC) transporter
JYK04_RS05785	COG4941	Belongs to the sigma-70 factor family
JYK04_RS05825	COG1278	Cold shock
JYK04_RS05835	COG1846	Transcriptional regulator
JYK04_RS05840	COG0513	Belongs to the DEAD box helicase family
JYK04_RS05925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JYK04_RS05925	COG0072	phenylalanine-tRNA ligase activity
JYK04_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS06035	COG2814	Major facilitator Superfamily
JYK04_RS06060	COG0577	efflux transmembrane transporter activity
JYK04_RS06060	COG1136	(ABC) transporter
JYK04_RS06085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JYK04_RS06095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYK04_RS06095	COG0463	Glycosyl transferase, family 2
JYK04_RS06095	COG0463	Glycosyl transferase, family 2
JYK04_RS06095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYK04_RS06140	COG0531	amino acid
JYK04_RS06155	COG2010	Cytochrome c
JYK04_RS06155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JYK04_RS06180	COG1053	succinate dehydrogenase
JYK04_RS06195	COG1672	PFAM Archaeal ATPase
JYK04_RS06195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
JYK04_RS06235	COG1024	Enoyl-CoA hydratase
JYK04_RS06245	COG2318	DinB family
JYK04_RS06270	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS06275	COG2366	antibiotic biosynthetic process
JYK04_RS06280	COG0387	Pfam Sodium calcium exchanger
JYK04_RS06290	COG2070	2-Nitropropane dioxygenase
JYK04_RS06335	COG3415	Transposase
JYK04_RS06335	COG2801	Transposase and inactivated derivatives
JYK04_RS06345	COG0515	serine threonine protein kinase
JYK04_RS06345	COG2815	serine threonine protein kinase
JYK04_RS06370	COG0346	lactoylglutathione lyase activity
JYK04_RS06390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JYK04_RS06390	COG0617	tRNA 3'-terminal CCA addition
JYK04_RS06390	COG0517	IMP dehydrogenase activity
JYK04_RS06450	COG1063	alcohol dehydrogenase
JYK04_RS06455	COG0517	IMP dehydrogenase activity
JYK04_RS06455	COG0516	GMP reductase activity
JYK04_RS06465	COG1309	transcriptional regulator
JYK04_RS06555	COG2890	protein-(glutamine-N5) methyltransferase activity
JYK04_RS06560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JYK04_RS06665	COG0542	response to heat
JYK04_RS06680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JYK04_RS06685	COG0443	Heat shock 70 kDa protein
JYK04_RS06745	COG0583	DNA-binding transcription factor activity
JYK04_RS06750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JYK04_RS06760	COG1113	amino acid transport
JYK04_RS06775	COG0662	Cupin 2, conserved barrel domain protein
JYK04_RS06820	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS06825	COG2318	DinB family
JYK04_RS06845	COG1349	DNA-binding transcription factor activity
JYK04_RS06850	COG2234	aminopeptidase activity
JYK04_RS06865	COG0156	8-amino-7-oxononanoate synthase activity
JYK04_RS06870	COG1063	alcohol dehydrogenase
JYK04_RS06890	COG3387	PFAM Glycoside hydrolase 15-related
JYK04_RS06905	COG2259	Doxx family
JYK04_RS06940	COG0640	Transcriptional regulator
JYK04_RS06945	COG0697	spore germination
JYK04_RS06950	COG0583	DNA-binding transcription factor activity
JYK04_RS06965	COG0714	Associated with various cellular activities
JYK04_RS07010	COG0531	amino acid
JYK04_RS07030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JYK04_RS07035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JYK04_RS07040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JYK04_RS07100	COG2376	Dihydroxyacetone kinase
JYK04_RS07105	COG1461	Dihydroxyacetone kinase
JYK04_RS07120	COG3585	molybdate ion transport
JYK04_RS07125	COG0725	ABC transporter, periplasmic molybdate-binding protein
JYK04_RS07140	COG2197	response regulator
JYK04_RS07145	COG4585	Histidine kinase
JYK04_RS07175	COG0842	Transport permease protein
JYK04_RS07175	COG1131	(ABC) transporter
JYK04_RS07175	COG1716	ATPase activity
JYK04_RS07210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JYK04_RS07260	COG0488	(ABC) transporter
JYK04_RS07265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JYK04_RS07290	COG0464	growth
JYK04_RS07315	COG1940	carbohydrate kinase activity
JYK04_RS07370	COG2124	cytochrome p450
JYK04_RS07380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYK04_RS07390	COG0494	nUDIX hydrolase
JYK04_RS07415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JYK04_RS07470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS07505	COG0671	phosphoesterase, PA-phosphatase related
JYK04_RS07535	COG0640	Transcriptional regulator
JYK04_RS07540	COG1902	pentaerythritol trinitrate reductase activity
JYK04_RS07555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JYK04_RS07565	COG2706	6-phosphogluconolactonase activity
JYK04_RS07570	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
JYK04_RS07595	COG3903	Transcriptional regulator
JYK04_RS07595	COG3629	intracellular signal transduction
JYK04_RS07610	COG2226	methyltransferase
JYK04_RS07610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS07610	COG3433	isochorismatase activity
JYK04_RS07615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JYK04_RS07625	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JYK04_RS07715	COG0475	glutathione-regulated potassium exporter activity
JYK04_RS07730	COG0406	alpha-ribazole phosphatase activity
JYK04_RS07745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JYK04_RS07760	COG2124	cytochrome p450
JYK04_RS07765	COG2072	flavoprotein involved in K transport
JYK04_RS07780	COG1132	(ABC) transporter
JYK04_RS07790	COG0277	FAD linked oxidase domain protein
JYK04_RS07795	COG1132	(ABC) transporter
JYK04_RS07800	COG1132	(ABC) transporter
JYK04_RS07815	COG1946	Acyl-CoA thioesterase
JYK04_RS07820	COG3012	SEC-C Motif Domain Protein
JYK04_RS07830	COG2018	Roadblock/LC7 domain
JYK04_RS07890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JYK04_RS07905	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS07985	COG2255	four-way junction helicase activity
JYK04_RS08050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS08050	COG0604	alcohol dehydrogenase
JYK04_RS08050	COG4221	oxidoreductase activity
JYK04_RS08050	COG3321	synthase
JYK04_RS08055	COG1309	transcriptional regulator
JYK04_RS08075	COG1595	DNA-templated transcription, initiation
JYK04_RS08200	COG0483	inositol monophosphate 1-phosphatase activity
JYK04_RS08205	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JYK04_RS08225	COG1404	Belongs to the peptidase S8 family
JYK04_RS08230	COG0154	amidase activity
JYK04_RS08250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JYK04_RS08355	COG3629	intracellular signal transduction
JYK04_RS08355	COG3903	Transcriptional regulator
JYK04_RS08405	COG1612	heme a metabolic process
JYK04_RS08410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JYK04_RS08440	COG0596	Alpha beta hydrolase
JYK04_RS08445	COG0596	Alpha beta hydrolase
JYK04_RS08460	COG4176	ABC-type proline glycine betaine transport system permease component
JYK04_RS08465	COG0517	IMP dehydrogenase activity
JYK04_RS08465	COG4175	Glycine betaine
JYK04_RS08475	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS08530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JYK04_RS08545	COG2382	esterase
JYK04_RS08550	COG1132	(ABC) transporter
JYK04_RS08560	COG1132	(ABC) transporter
JYK04_RS08565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JYK04_RS08570	COG1120	ATPase activity
JYK04_RS08575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYK04_RS08580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYK04_RS08590	COG2409	Drug exporters of the RND superfamily
JYK04_RS08595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS08595	COG3321	synthase
JYK04_RS08655	COG0515	serine threonine protein kinase
JYK04_RS08660	COG3842	ATPase activity
JYK04_RS08695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JYK04_RS08730	COG0702	epimerase
JYK04_RS08740	COG1595	DNA-templated transcription, initiation
JYK04_RS08770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JYK04_RS08775	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JYK04_RS08795	COG0517	IMP dehydrogenase activity
JYK04_RS08795	COG0516	GMP reductase activity
JYK04_RS08800	COG3409	Peptidoglycan-binding domain 1 protein
JYK04_RS08820	COG0745	RESPONSE REGULATOR receiver
JYK04_RS08840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JYK04_RS08935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JYK04_RS09095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JYK04_RS09100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JYK04_RS09110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS09150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JYK04_RS09160	COG2814	Major facilitator Superfamily
JYK04_RS09180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JYK04_RS09185	COG1309	transcriptional regulator
JYK04_RS09195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JYK04_RS09215	COG2824	Alkylphosphonate utilization operon protein PhnA
JYK04_RS09245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JYK04_RS09265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JYK04_RS09290	COG4249	Peptidase C14 caspase catalytic subunit p20
JYK04_RS09290	COG2319	Wd-40 repeat
JYK04_RS09295	COG1396	sequence-specific DNA binding
JYK04_RS09295	COG1917	Cupin 2, conserved barrel domain protein
JYK04_RS09320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS09325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS09330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS09335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS09385	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS09395	COG0242	peptide deformylase activity
JYK04_RS09405	COG3442	glutamine amidotransferase
JYK04_RS09410	COG0205	6-phosphofructokinase activity
JYK04_RS09435	COG0829	nickel cation binding
JYK04_RS09440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JYK04_RS09450	COG0804	urea catabolic process
JYK04_RS09455	COG0832	Belongs to the urease beta subunit family
JYK04_RS09460	COG0831	urea catabolic process
JYK04_RS09485	COG0156	8-amino-7-oxononanoate synthase activity
JYK04_RS09490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JYK04_RS09495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JYK04_RS09500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JYK04_RS09505	COG0456	acetyltransferase
JYK04_RS09525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JYK04_RS09565	COG4585	Histidine kinase
JYK04_RS09570	COG2197	response regulator
JYK04_RS09575	COG1940	carbohydrate kinase activity
JYK04_RS09580	COG2188	Transcriptional regulator
JYK04_RS09585	COG2267	carboxylic ester hydrolase activity
JYK04_RS09610	COG1522	sequence-specific DNA binding
JYK04_RS09615	COG0419	ATPase involved in DNA repair
JYK04_RS09620	COG0420	3'-5' exonuclease activity
JYK04_RS09625	COG1739	Uncharacterized protein family UPF0029
JYK04_RS09635	COG1832	CoA-binding protein
JYK04_RS09650	COG0110	maltose O-acetyltransferase activity
JYK04_RS09665	COG1472	Belongs to the glycosyl hydrolase 3 family
JYK04_RS09695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JYK04_RS09710	COG1968	undecaprenyl-diphosphatase activity
JYK04_RS09725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JYK04_RS09735	COG2318	DinB family
JYK04_RS09750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JYK04_RS09755	COG0747	negative chemotaxis
JYK04_RS09790	COG0583	DNA-binding transcription factor activity
JYK04_RS09810	COG0697	spore germination
JYK04_RS09825	COG1695	Transcriptional regulator
JYK04_RS09835	COG2205	protein histidine kinase activity
JYK04_RS09875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JYK04_RS09875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JYK04_RS09885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JYK04_RS09925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JYK04_RS09955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JYK04_RS09965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JYK04_RS09980	COG0640	Transcriptional regulator
JYK04_RS09990	COG1051	belongs to the nudix hydrolase family
JYK04_RS10005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS10020	COG2018	Roadblock/LC7 domain
JYK04_RS10050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JYK04_RS10055	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JYK04_RS10060	COG1984	allophanate hydrolase subunit 2
JYK04_RS10095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS10105	COG2270	Major facilitator Superfamily
JYK04_RS10115	COG3030	protein affecting phage T7 exclusion by the F plasmid
JYK04_RS10120	COG0463	Glycosyl transferase, family 2
JYK04_RS10155	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS10160	COG1309	transcriptional regulator
JYK04_RS10210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JYK04_RS10215	COG0140	phosphoribosyl-ATP diphosphatase activity
JYK04_RS10220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JYK04_RS10225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JYK04_RS10225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JYK04_RS10230	COG3201	nicotinamide mononucleotide transporter
JYK04_RS10250	COG1595	DNA-templated transcription, initiation
JYK04_RS10260	COG1846	Transcriptional regulator
JYK04_RS10260	COG1940	carbohydrate kinase activity
JYK04_RS10265	COG0738	Major facilitator superfamily
JYK04_RS10270	COG2233	PERMEase
JYK04_RS10290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JYK04_RS10300	COG0456	acetyltransferase
JYK04_RS10310	COG0531	amino acid
JYK04_RS10320	COG2755	lipolytic protein G-D-S-L family
JYK04_RS10340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JYK04_RS10345	COG3275	phosphorelay sensor kinase activity
JYK04_RS10375	COG3548	integral membrane protein
JYK04_RS10415	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS10425	COG0489	protein tyrosine kinase activity
JYK04_RS10430	COG2208	phosphoserine phosphatase activity
JYK04_RS10430	COG2770	Histidine kinase
JYK04_RS10450	COG1366	Belongs to the anti-sigma-factor antagonist family
JYK04_RS10470	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JYK04_RS10490	COG0028	Belongs to the TPP enzyme family
JYK04_RS10505	COG0492	ferredoxin-NADP+ reductase activity
JYK04_RS10540	COG2390	Transcriptional regulator
JYK04_RS10545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JYK04_RS10555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JYK04_RS10570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JYK04_RS10585	COG0194	GDP metabolic process
JYK04_RS10595	COG0284	orotidine-5'-phosphate decarboxylase activity
JYK04_RS10600	COG0167	dihydroorotate dehydrogenase activity
JYK04_RS10605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JYK04_RS10610	COG0505	Belongs to the CarA family
JYK04_RS10620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JYK04_RS10625	COG0540	Belongs to the ATCase OTCase family
JYK04_RS10630	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JYK04_RS10640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JYK04_RS10645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JYK04_RS10650	COG0006	proline dipeptidase activity
JYK04_RS10660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JYK04_RS10665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JYK04_RS10670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JYK04_RS10675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JYK04_RS10685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JYK04_RS10695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JYK04_RS10700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JYK04_RS10720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JYK04_RS10740	COG0124	histidyl-tRNA synthetase
JYK04_RS10750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JYK04_RS10755	COG1196	nuclear chromosome segregation
JYK04_RS10760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JYK04_RS10765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JYK04_RS10770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JYK04_RS10775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JYK04_RS10785	COG2255	four-way junction helicase activity
JYK04_RS10790	COG0632	four-way junction helicase activity
JYK04_RS10795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JYK04_RS10800	COG0217	transcriptional regulatory protein
JYK04_RS10805	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JYK04_RS10810	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JYK04_RS10825	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS10830	COG1560	Kdo2-lipid A biosynthetic process
JYK04_RS10835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JYK04_RS10860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JYK04_RS10865	COG0456	acetyltransferase
JYK04_RS10885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JYK04_RS10935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JYK04_RS10940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JYK04_RS10985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JYK04_RS10985	COG1648	precorrin-2 dehydrogenase activity
JYK04_RS10990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JYK04_RS11005	COG1464	Belongs to the NlpA lipoprotein family
JYK04_RS11010	COG2011	ABC-type metal ion transport system permease component
JYK04_RS11015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JYK04_RS11045	COG0204	Acyl-transferase
JYK04_RS11045	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS11055	COG0477	Major facilitator Superfamily
JYK04_RS11070	COG0165	Argininosuccinate lyase
JYK04_RS11075	COG0137	argininosuccinate synthase activity
JYK04_RS11095	COG1438	arginine binding
JYK04_RS11100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JYK04_RS11105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JYK04_RS11110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JYK04_RS11115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JYK04_RS11130	COG0697	spore germination
JYK04_RS11140	COG1649	PFAM Uncharacterised BCR, COG1649
JYK04_RS11165	COG0072	phenylalanine-tRNA ligase activity
JYK04_RS11165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JYK04_RS11170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JYK04_RS11175	COG5002	protein histidine kinase activity
JYK04_RS11180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JYK04_RS11185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JYK04_RS11190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JYK04_RS11195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JYK04_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS11235	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS11240	COG0174	glutamine synthetase
JYK04_RS11250	COG1113	amino acid transport
JYK04_RS11255	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JYK04_RS11290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JYK04_RS11310	COG1309	transcriptional regulator
JYK04_RS11325	COG0805	protein transport
JYK04_RS11330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JYK04_RS11365	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JYK04_RS11375	COG1609	Transcriptional regulator
JYK04_RS11380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JYK04_RS11385	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JYK04_RS11400	COG4122	O-methyltransferase activity
JYK04_RS11405	COG1222	aaa ATPase
JYK04_RS11425	COG0517	IMP dehydrogenase activity
JYK04_RS11425	COG1994	Peptidase M50
JYK04_RS11435	COG2197	response regulator
JYK04_RS11455	COG1410	methionine synthase
JYK04_RS11455	COG0646	methionine synthase
JYK04_RS11460	COG1414	Transcriptional regulator
JYK04_RS11465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JYK04_RS11470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JYK04_RS11475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JYK04_RS11490	COG0215	cysteine-tRNA ligase activity
JYK04_RS11510	COG0598	Magnesium transport protein CorA
JYK04_RS11520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS11525	COG0667	Aldo Keto reductase
JYK04_RS11555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JYK04_RS11565	COG1595	DNA-templated transcription, initiation
JYK04_RS11580	COG1113	amino acid transport
JYK04_RS11605	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JYK04_RS11610	COG2149	membrane
JYK04_RS11635	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS11650	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS11660	COG3876	Protein conserved in bacteria
JYK04_RS11680	COG0789	Transcriptional regulator
JYK04_RS11700	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS11735	COG2851	Citrate transporter
JYK04_RS11740	COG0243	molybdopterin cofactor binding
JYK04_RS11745	COG1309	transcriptional regulator
JYK04_RS11765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JYK04_RS11770	COG2188	Transcriptional regulator
JYK04_RS11810	COG0515	serine threonine protein kinase
JYK04_RS11815	COG2755	lipolytic protein G-D-S-L family
JYK04_RS11865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JYK04_RS11870	COG0587	DNA-directed DNA polymerase activity
JYK04_RS11900	COG0641	radical SAM
JYK04_RS11940	COG1799	cell septum assembly
JYK04_RS11945	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS11950	COG0477	Major facilitator Superfamily
JYK04_RS11960	COG0671	phosphoesterase, PA-phosphatase related
JYK04_RS11995	COG1160	GTP binding
JYK04_RS12005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JYK04_RS12030	COG3541	Predicted nucleotidyltransferase
JYK04_RS12035	COG1397	ADP-ribosylglycohydrolase
JYK04_RS12055	COG1187	pseudouridine synthase activity
JYK04_RS12060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JYK04_RS12065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JYK04_RS12080	COG0686	Belongs to the AlaDH PNT family
JYK04_RS12090	COG0494	nUDIX hydrolase
JYK04_RS12095	COG0504	CTP synthase activity
JYK04_RS12100	COG3387	PFAM Glycoside hydrolase 15-related
JYK04_RS12110	COG1752	Esterase of the alpha-beta hydrolase superfamily
JYK04_RS12110	COG1752	Esterase of the alpha-beta hydrolase superfamily
JYK04_RS12125	COG0297	glycogen (starch) synthase activity
JYK04_RS12130	COG0497	DNA recombination
JYK04_RS12135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JYK04_RS12155	COG1120	ATPase activity
JYK04_RS12160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYK04_RS12165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYK04_RS12170	COG0647	UMP catabolic process
JYK04_RS12205	COG2094	Belongs to the DNA glycosylase MPG family
JYK04_RS12215	COG1881	PFAM PEBP family protein
JYK04_RS12240	COG1119	ATPase activity
JYK04_RS12255	COG2197	response regulator
JYK04_RS12260	COG4585	Histidine kinase
JYK04_RS12270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JYK04_RS12280	COG0842	Transport permease protein
JYK04_RS12280	COG1131	(ABC) transporter
JYK04_RS12280	COG1716	ATPase activity
JYK04_RS12290	COG3830	Belongs to the UPF0237 family
JYK04_RS12290	COG0560	Phosphoserine phosphatase
JYK04_RS12310	COG2186	Transcriptional regulator
JYK04_RS12320	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JYK04_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS12340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JYK04_RS12360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JYK04_RS12365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JYK04_RS12380	COG1063	alcohol dehydrogenase
JYK04_RS12470	COG1302	Protein conserved in bacteria
JYK04_RS12475	COG1024	Enoyl-CoA hydratase
JYK04_RS12485	COG0488	(ABC) transporter
JYK04_RS12520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JYK04_RS12525	COG1492	cobalamin metabolic process
JYK04_RS12540	COG1797	cobyrinic acid a,c-diamide synthase activity
JYK04_RS12570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JYK04_RS12585	COG0768	penicillin binding
JYK04_RS12590	COG2197	response regulator
JYK04_RS12595	COG4585	Histidine kinase
JYK04_RS12665	COG2171	N-acyltransferase activity
JYK04_RS12680	COG3226	Transcriptional regulator
JYK04_RS12685	COG2076	Multidrug Resistance protein
JYK04_RS12695	COG2151	metal-sulfur cluster biosynthetic enzyme
JYK04_RS12700	COG0822	iron-sulfur transferase activity
JYK04_RS12705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JYK04_RS12710	COG0396	ATPase activity
JYK04_RS12720	COG0719	Fe-S assembly protein
JYK04_RS12750	COG1612	heme a metabolic process
JYK04_RS12765	COG0109	protoheme IX farnesyltransferase activity
JYK04_RS12775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JYK04_RS12790	COG0363	glucosamine-6-phosphate deaminase activity
JYK04_RS12795	COG0166	Belongs to the GPI family
JYK04_RS12805	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JYK04_RS12810	COG0149	triose-phosphate isomerase activity
JYK04_RS12815	COG0126	phosphoglycerate kinase activity
JYK04_RS12820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JYK04_RS12830	COG1481	regulation of sporulation
JYK04_RS12840	COG1660	Displays ATPase and GTPase activities
JYK04_RS12845	COG0322	excinuclease ABC activity
JYK04_RS12885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JYK04_RS12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYK04_RS12900	COG0477	Major facilitator Superfamily
JYK04_RS12920	COG0556	nucleotide-excision repair
JYK04_RS12925	COG0584	glycerophosphoryl diester phosphodiesterase
JYK04_RS12930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JYK04_RS12950	COG2313	pseudouridylate synthase activity
JYK04_RS12990	COG4279	zinc finger
JYK04_RS12995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JYK04_RS13020	COG0237	dephospho-CoA kinase activity
JYK04_RS13030	COG0539	negative regulation of cytoplasmic translation
JYK04_RS13035	COG1073	alpha beta
JYK04_RS13035	COG2226	methyltransferase
JYK04_RS13040	COG1643	Atp-dependent helicase
JYK04_RS13080	COG2050	protein possibly involved in aromatic compounds catabolism
JYK04_RS13150	COG0737	Belongs to the 5'-nucleotidase family
JYK04_RS13175	COG1605	Chorismate mutase
JYK04_RS13175	COG0287	Prephenate dehydrogenase
JYK04_RS13205	COG2267	carboxylic ester hydrolase activity
JYK04_RS13210	COG0673	inositol 2-dehydrogenase activity
JYK04_RS13230	COG1024	Enoyl-CoA hydratase
JYK04_RS13250	COG2365	Tyrosine phosphatase family
JYK04_RS13255	COG0513	Belongs to the DEAD box helicase family
JYK04_RS13260	COG1278	Cold shock
JYK04_RS13270	COG0183	Belongs to the thiolase family
JYK04_RS13275	COG1309	transcriptional regulator
JYK04_RS13295	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS13300	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS13335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS13365	COG1131	(ABC) transporter
JYK04_RS13370	COG1725	Transcriptional regulator
JYK04_RS13425	COG0069	glutamate synthase activity
JYK04_RS13425	COG0067	glutamate synthase
JYK04_RS13425	COG0070	glutamate synthase
JYK04_RS13460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JYK04_RS13465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JYK04_RS13470	COG2301	Belongs to the HpcH HpaI aldolase family
JYK04_RS13475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JYK04_RS13485	COG0159	tryptophan synthase activity
JYK04_RS13490	COG0133	tryptophan synthase activity
JYK04_RS13500	COG0134	indole-3-glycerol-phosphate synthase activity
JYK04_RS13525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JYK04_RS13535	COG0107	imidazoleglycerol-phosphate synthase activity
JYK04_RS13540	COG0251	oxidation-reduction process
JYK04_RS13545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JYK04_RS13550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JYK04_RS13560	COG0131	Imidazoleglycerol-phosphate dehydratase
JYK04_RS13565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JYK04_RS13570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JYK04_RS13585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JYK04_RS13615	COG0587	DNA-directed DNA polymerase activity
JYK04_RS13680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JYK04_RS13690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JYK04_RS13705	COG1799	cell septum assembly
JYK04_RS13725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JYK04_RS13730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JYK04_RS13740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JYK04_RS13745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JYK04_RS13755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JYK04_RS13760	COG0768	penicillin binding
JYK04_RS13770	COG0275	rRNA processing
JYK04_RS13780	COG0714	Associated with various cellular activities
JYK04_RS13795	COG1309	transcriptional regulator
JYK04_RS13800	COG1511	domain protein
JYK04_RS13805	COG1131	(ABC) transporter
JYK04_RS13815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JYK04_RS13845	COG0352	thiamine-phosphate diphosphorylase activity
JYK04_RS13860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JYK04_RS13860	COG2022	thiamine diphosphate biosynthetic process
JYK04_RS13870	COG2022	thiamine diphosphate biosynthetic process
JYK04_RS13875	COG2815	serine threonine protein kinase
JYK04_RS13875	COG0515	serine threonine protein kinase
JYK04_RS13880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JYK04_RS13890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JYK04_RS13895	COG2193	ferroxidase activity
JYK04_RS13905	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JYK04_RS13920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JYK04_RS13925	COG0205	6-phosphofructokinase activity
JYK04_RS13930	COG2197	response regulator
JYK04_RS13935	COG4585	Histidine kinase
JYK04_RS13960	COG1940	carbohydrate kinase activity
JYK04_RS13970	COG0003	Pfam Anion-transporting ATPase
JYK04_RS13995	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS14035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JYK04_RS14040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JYK04_RS14045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JYK04_RS14050	COG0723	plastoquinol--plastocyanin reductase activity
JYK04_RS14055	COG2010	Cytochrome c
JYK04_RS14060	COG1845	cytochrome c oxidase, subunit III
JYK04_RS14070	COG1376	ErfK ybiS ycfS ynhG family protein
JYK04_RS14080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JYK04_RS14085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JYK04_RS14095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JYK04_RS14115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JYK04_RS14120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JYK04_RS14125	COG2197	response regulator
JYK04_RS14155	COG2226	methyltransferase
JYK04_RS14165	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
JYK04_RS14170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JYK04_RS14175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JYK04_RS14175	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JYK04_RS14205	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS14215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JYK04_RS14220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JYK04_RS14225	COG0508	dehydrogenase complex catalyzes the overall conversion of
JYK04_RS14235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JYK04_RS14280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JYK04_RS14285	COG0321	lipoyl(octanoyl) transferase activity
JYK04_RS14330	COG0596	Alpha beta hydrolase
JYK04_RS14330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JYK04_RS14335	COG1846	Transcriptional regulator
JYK04_RS14340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS14350	COG0673	inositol 2-dehydrogenase activity
JYK04_RS14360	COG0745	RESPONSE REGULATOR receiver
JYK04_RS14380	COG2365	Tyrosine phosphatase family
JYK04_RS14445	COG0366	Alpha amylase catalytic
JYK04_RS14450	COG3833	ABC-type maltose transport systems, permease component
JYK04_RS14455	COG1175	transmembrane transport
JYK04_RS14465	COG0366	Alpha amylase catalytic
JYK04_RS14470	COG1609	Transcriptional regulator
JYK04_RS14495	COG3511	phospholipase C
JYK04_RS14550	COG2340	Cysteine-rich secretory protein family
JYK04_RS14575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JYK04_RS14615	COG0174	glutamine synthetase
JYK04_RS14650	COG2132	Multicopper oxidase
JYK04_RS14660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JYK04_RS14660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JYK04_RS14670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JYK04_RS14690	COG1994	Peptidase M50
JYK04_RS14755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JYK04_RS14760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYK04_RS14765	COG1120	ATPase activity
JYK04_RS14775	COG2837	iron assimilation
JYK04_RS14780	COG0672	)-iron permease
JYK04_RS14790	COG0384	phenazine biosynthesis protein PhzF
JYK04_RS14800	COG2814	Major facilitator Superfamily
JYK04_RS14810	COG1834	amidinotransferase
JYK04_RS14825	COG3022	response to hydroperoxide
JYK04_RS14860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JYK04_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS14880	COG2030	dehydratase
JYK04_RS14890	COG1595	DNA-templated transcription, initiation
JYK04_RS14910	COG0183	Belongs to the thiolase family
JYK04_RS14915	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS14935	COG0583	DNA-binding transcription factor activity
JYK04_RS14980	COG0515	serine threonine protein kinase
JYK04_RS14980	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS14995	COG0515	serine threonine protein kinase
JYK04_RS14995	COG2815	serine threonine protein kinase
JYK04_RS15015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS15050	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS15055	COG1309	transcriptional regulator
JYK04_RS15080	COG1657	PFAM Prenyltransferase squalene oxidase
JYK04_RS15095	COG3845	ABC transporter
JYK04_RS15110	COG0183	Belongs to the thiolase family
JYK04_RS15115	COG2124	cytochrome p450
JYK04_RS15130	COG3415	Transposase
JYK04_RS15130	COG2801	Transposase and inactivated derivatives
JYK04_RS15175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JYK04_RS15180	COG2318	DinB family
JYK04_RS15255	COG1358	cellular component organization or biogenesis
JYK04_RS15300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JYK04_RS15305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JYK04_RS15315	COG1309	transcriptional regulator
JYK04_RS15330	COG0667	Aldo Keto reductase
JYK04_RS15335	COG0789	Transcriptional regulator
JYK04_RS15360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS15365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JYK04_RS15370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JYK04_RS15390	COG1309	transcriptional regulator
JYK04_RS15400	COG2084	Dehydrogenase
JYK04_RS15405	COG0583	DNA-binding transcription factor activity
JYK04_RS15420	COG1733	regulation of RNA biosynthetic process
JYK04_RS15435	COG1764	response to oxidative stress
JYK04_RS15440	COG2130	NADP-dependent
JYK04_RS15460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JYK04_RS15465	COG1077	Cell shape determining protein MreB Mrl
JYK04_RS15480	COG1522	sequence-specific DNA binding
JYK04_RS15495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JYK04_RS15495	COG0825	malonyl-CoA metabolic process
JYK04_RS15510	COG0662	Cupin 2, conserved barrel domain protein
JYK04_RS15520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JYK04_RS15545	COG1070	Carbohydrate kinase
JYK04_RS15580	COG0243	molybdopterin cofactor binding
JYK04_RS15595	COG2949	membrane
JYK04_RS15605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JYK04_RS15615	COG0358	DNA primase activity
JYK04_RS15645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JYK04_RS15645	COG1017	nitric oxide dioxygenase activity
JYK04_RS15650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JYK04_RS15655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JYK04_RS15655	COG2146	nitrite reductase [NAD(P)H] activity
JYK04_RS15660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JYK04_RS15660	COG2146	nitrite reductase [NAD(P)H] activity
JYK04_RS15680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JYK04_RS15680	COG0574	Belongs to the PEP-utilizing enzyme family
JYK04_RS15690	COG0477	Major facilitator Superfamily
JYK04_RS15705	COG0667	Aldo Keto reductase
JYK04_RS15710	COG1309	transcriptional regulator
JYK04_RS15720	COG0423	glycine-tRNA ligase activity
JYK04_RS15730	COG1121	(ABC) transporter
JYK04_RS15735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JYK04_RS15750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JYK04_RS15755	COG1381	Involved in DNA repair and RecF pathway recombination
JYK04_RS15760	COG2233	PERMEase
JYK04_RS15770	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS15775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JYK04_RS15800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JYK04_RS15815	COG2271	Major facilitator Superfamily
JYK04_RS15825	COG2315	Protein conserved in bacteria
JYK04_RS15835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JYK04_RS15845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JYK04_RS15850	COG1234	tRNA 3'-trailer cleavage
JYK04_RS15855	COG0537	adenosine 5'-monophosphoramidase activity
JYK04_RS15870	COG0484	heat shock protein binding
JYK04_RS15875	COG1420	regulation of RNA biosynthetic process
JYK04_RS15900	COG0481	GTPase activity
JYK04_RS15905	COG0268	Binds directly to 16S ribosomal RNA
JYK04_RS15920	COG2353	YceI-like domain
JYK04_RS15935	COG1307	EDD domain protein, DegV family
JYK04_RS15945	COG0495	leucyl-tRNA aminoacylation
JYK04_RS15965	COG0588	phosphoglycerate mutase activity
JYK04_RS15970	COG0799	negative regulation of ribosome biogenesis
JYK04_RS15980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JYK04_RS15990	COG0501	Belongs to the peptidase M48B family
JYK04_RS16005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JYK04_RS16015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JYK04_RS16030	COG0463	Glycosyl transferase, family 2
JYK04_RS16030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYK04_RS16035	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS16040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JYK04_RS16045	COG1215	transferase activity, transferring glycosyl groups
JYK04_RS16050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JYK04_RS16055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JYK04_RS16060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JYK04_RS16065	COG1530	ribonuclease E activity
JYK04_RS16090	COG0772	Belongs to the SEDS family
JYK04_RS16095	COG0768	penicillin binding
JYK04_RS16110	COG1077	Cell shape determining protein MreB Mrl
JYK04_RS16115	COG0105	UTP biosynthetic process
JYK04_RS16125	COG0285	dihydrofolate synthase activity
JYK04_RS16130	COG1077	Cell shape determining protein MreB Mrl
JYK04_RS16140	COG0525	valine-tRNA ligase activity
JYK04_RS16150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JYK04_RS16155	COG0740	serine-type endopeptidase activity
JYK04_RS16160	COG0740	serine-type endopeptidase activity
JYK04_RS16165	COG0544	peptidyl-prolyl cis-trans isomerase activity
JYK04_RS16200	COG1136	(ABC) transporter
JYK04_RS16210	COG4552	Acetyltransferase involved in intracellular survival and related
JYK04_RS16225	COG1113	amino acid transport
JYK04_RS16235	COG1113	amino acid transport
JYK04_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS16245	COG1113	amino acid transport
JYK04_RS16250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JYK04_RS16255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JYK04_RS16290	COG2234	aminopeptidase activity
JYK04_RS16305	COG0583	DNA-binding transcription factor activity
JYK04_RS16315	COG0697	spore germination
JYK04_RS16325	COG1846	Transcriptional regulator
JYK04_RS16340	COG3291	Pkd domain containing protein
JYK04_RS16340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JYK04_RS16350	COG0668	transmembrane transport
JYK04_RS16365	COG1175	transmembrane transport
JYK04_RS16370	COG0395	ABC-type sugar transport system, permease component
JYK04_RS16375	COG1486	melibiose metabolic process
JYK04_RS16390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JYK04_RS16400	COG0515	serine threonine protein kinase
JYK04_RS16420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JYK04_RS16425	COG2346	COG2346, Truncated hemoglobins
JYK04_RS16460	COG0629	single-stranded DNA binding
JYK04_RS16555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS16580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JYK04_RS16650	COG0515	serine threonine protein kinase
JYK04_RS16650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS16675	COG3962	Belongs to the TPP enzyme family
JYK04_RS16680	COG3718	enzyme involved in inositol metabolism
JYK04_RS16695	COG0673	inositol 2-dehydrogenase activity
JYK04_RS16705	COG2409	Drug exporters of the RND superfamily
JYK04_RS16730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JYK04_RS16740	COG1846	Transcriptional regulator
JYK04_RS16740	COG0456	acetyltransferase
JYK04_RS16755	COG1472	Belongs to the glycosyl hydrolase 3 family
JYK04_RS16785	COG0028	Belongs to the TPP enzyme family
JYK04_RS16810	COG1946	Acyl-CoA thioesterase
JYK04_RS16830	COG1309	transcriptional regulator
JYK04_RS16835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JYK04_RS16850	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS16865	COG2375	cellular response to nickel ion
JYK04_RS16870	COG0076	glutamate decarboxylase activity
JYK04_RS16875	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JYK04_RS16905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JYK04_RS16915	COG0589	response to stress
JYK04_RS16925	COG4977	sequence-specific DNA binding
JYK04_RS16930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JYK04_RS16955	COG0395	ABC-type sugar transport system, permease component
JYK04_RS16995	COG0745	RESPONSE REGULATOR receiver
JYK04_RS17020	COG0406	alpha-ribazole phosphatase activity
JYK04_RS17130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS17155	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS17160	COG3397	chitin binding
JYK04_RS17225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JYK04_RS17230	COG2188	Transcriptional regulator
JYK04_RS17245	COG0673	inositol 2-dehydrogenase activity
JYK04_RS17255	COG0706	membrane insertase activity
JYK04_RS17265	COG3764	Sortase (surface protein transpeptidase)
JYK04_RS17305	COG2733	membrane
JYK04_RS17315	COG4555	ABC transporter
JYK04_RS17330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JYK04_RS17370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JYK04_RS17380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JYK04_RS17385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JYK04_RS17390	COG1263	PTS System
JYK04_RS17395	COG1263	PTS System
JYK04_RS17400	COG1234	tRNA 3'-trailer cleavage
JYK04_RS17410	COG3189	MarR family transcriptional regulator
JYK04_RS17430	COG1113	amino acid transport
JYK04_RS17440	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JYK04_RS17450	COG1335	isochorismatase
JYK04_RS17485	COG0277	FAD linked oxidase domain protein
JYK04_RS17495	COG3185	4-Hydroxyphenylpyruvate dioxygenase
JYK04_RS17535	COG3654	unkown
JYK04_RS17575	COG1404	Belongs to the peptidase S8 family
JYK04_RS17605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JYK04_RS17615	COG1678	Uncharacterized ACR, COG1678
JYK04_RS17620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JYK04_RS17625	COG0776	regulation of translation
JYK04_RS17635	COG3973	AAA domain
JYK04_RS17660	COG0583	DNA-binding transcription factor activity
JYK04_RS17685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JYK04_RS17690	COG0793	Belongs to the peptidase S41A family
JYK04_RS17695	COG2177	Part of the ABC transporter FtsEX involved in
JYK04_RS17700	COG2884	Cell division ATP-binding protein ftsE
JYK04_RS17710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JYK04_RS17720	COG0515	serine threonine protein kinase
JYK04_RS17725	COG0515	serine threonine protein kinase
JYK04_RS17740	COG1175	transmembrane transport
JYK04_RS17745	COG0395	ABC-type sugar transport system, permease component
JYK04_RS17750	COG0463	Glycosyl transferase, family 2
JYK04_RS17750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYK04_RS17765	COG1134	teichoic acid transport
JYK04_RS17765	COG1388	LysM domain
JYK04_RS17775	COG0546	phosphoglycolate phosphatase activity
JYK04_RS17790	COG0653	protein targeting
JYK04_RS17805	COG2197	response regulator
JYK04_RS17810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JYK04_RS17820	COG0823	Involved in the tonB-independent uptake of proteins
JYK04_RS17825	COG5000	phosphorelay sensor kinase activity
JYK04_RS17825	COG5002	protein histidine kinase activity
JYK04_RS17830	COG0745	RESPONSE REGULATOR receiver
JYK04_RS17850	COG0714	Associated with various cellular activities
JYK04_RS17900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JYK04_RS17905	COG0681	Belongs to the peptidase S26 family
JYK04_RS17915	COG1482	cell wall glycoprotein biosynthetic process
JYK04_RS17925	COG2835	tetraacyldisaccharide 4'-kinase activity
JYK04_RS17930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JYK04_RS17965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JYK04_RS17970	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
JYK04_RS17970	COG0778	Nitroreductase
JYK04_RS17990	COG1316	TRANSCRIPTIONal
JYK04_RS17995	COG1316	TRANSCRIPTIONal
JYK04_RS18015	COG1607	acyl-coa hydrolase
JYK04_RS18020	COG1316	TRANSCRIPTIONal
JYK04_RS18025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JYK04_RS18040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JYK04_RS18055	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JYK04_RS18070	COG2205	protein histidine kinase activity
JYK04_RS18075	COG0745	RESPONSE REGULATOR receiver
JYK04_RS18080	COG3104	oligopeptide transport
JYK04_RS18105	COG1228	amidohydrolase
JYK04_RS18120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JYK04_RS18135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS18155	COG2755	lipolytic protein G-D-S-L family
JYK04_RS18160	COG0183	Belongs to the thiolase family
JYK04_RS18195	COG1136	(ABC) transporter
JYK04_RS18200	COG0577	efflux transmembrane transporter activity
JYK04_RS18205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JYK04_RS18210	COG1252	NADH dehydrogenase
JYK04_RS18230	COG0148	phosphopyruvate hydratase activity
JYK04_RS18245	COG2124	cytochrome p450
JYK04_RS18300	COG0577	efflux transmembrane transporter activity
JYK04_RS18305	COG1136	(ABC) transporter
JYK04_RS18310	COG0477	Major facilitator Superfamily
JYK04_RS18325	COG0596	Alpha beta hydrolase
JYK04_RS18360	COG4585	Histidine kinase
JYK04_RS18370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JYK04_RS18375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JYK04_RS18380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JYK04_RS18385	COG0193	aminoacyl-tRNA hydrolase activity
JYK04_RS18390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JYK04_RS18400	COG1309	transcriptional regulator
JYK04_RS18410	COG4106	trans-aconitate 2-methyltransferase activity
JYK04_RS18415	COG1846	Transcriptional regulator
JYK04_RS18420	COG2197	response regulator
JYK04_RS18450	COG0488	(ABC) transporter
JYK04_RS18460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JYK04_RS18465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JYK04_RS18470	COG3584	3D domain protein
JYK04_RS18470	COG3583	domain protein
JYK04_RS18475	COG0084	hydrolase, TatD family'
JYK04_RS18510	COG0442	prolyl-tRNA aminoacylation
JYK04_RS18515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JYK04_RS18520	COG1122	ATPase activity
JYK04_RS18530	COG0310	cobalt ion transport
JYK04_RS18540	COG2409	Drug exporters of the RND superfamily
JYK04_RS18550	COG0793	Belongs to the peptidase S41A family
JYK04_RS18550	COG4946	Tricorn protease homolog
JYK04_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS18565	COG2267	carboxylic ester hydrolase activity
JYK04_RS18580	COG0708	Exodeoxyribonuclease III
JYK04_RS18590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JYK04_RS18615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JYK04_RS18620	COG0521	Mo-molybdopterin cofactor biosynthetic process
JYK04_RS18620	COG0315	cyclic pyranopterin monophosphate synthase activity
JYK04_RS18625	COG0315	cyclic pyranopterin monophosphate synthase activity
JYK04_RS18635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JYK04_RS18640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JYK04_RS18650	COG3263	regulation of cellular component size
JYK04_RS18665	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JYK04_RS18695	COG1970	mechanosensitive ion channel activity
JYK04_RS18745	COG0492	ferredoxin-NADP+ reductase activity
JYK04_RS18780	COG0728	peptidoglycan biosynthetic process
JYK04_RS18790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JYK04_RS18795	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS18865	COG1349	DNA-binding transcription factor activity
JYK04_RS18870	COG0477	Major facilitator Superfamily
JYK04_RS18885	COG1247	-acetyltransferase
JYK04_RS18890	COG3384	dioxygenase
JYK04_RS18915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS18920	COG0745	RESPONSE REGULATOR receiver
JYK04_RS18925	COG2205	protein histidine kinase activity
JYK04_RS18930	COG1136	(ABC) transporter
JYK04_RS18980	COG0277	FAD linked oxidase domain protein
JYK04_RS19000	COG2205	protein histidine kinase activity
JYK04_RS19015	COG1686	Belongs to the peptidase S11 family
JYK04_RS19045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS19095	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JYK04_RS19100	COG2365	Tyrosine phosphatase family
JYK04_RS19145	COG0346	lactoylglutathione lyase activity
JYK04_RS19150	COG1902	pentaerythritol trinitrate reductase activity
JYK04_RS19200	COG4335	DNA alkylation repair
JYK04_RS19250	COG0494	nUDIX hydrolase
JYK04_RS19310	COG1024	Enoyl-CoA hydratase
JYK04_RS19325	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS19325	COG0515	serine threonine protein kinase
JYK04_RS19345	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS19350	COG0183	Belongs to the thiolase family
JYK04_RS19360	COG0259	pyridoxamine-phosphate oxidase activity
JYK04_RS19375	COG2072	flavoprotein involved in K transport
JYK04_RS19390	COG1024	Enoyl-CoA hydratase
JYK04_RS19405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JYK04_RS19420	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS19425	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS19455	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS19460	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS19470	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS19525	COG1131	(ABC) transporter
JYK04_RS19550	COG4821	SIS domain
JYK04_RS19565	COG0259	pyridoxamine-phosphate oxidase activity
JYK04_RS19595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JYK04_RS19625	COG0247	lactate metabolic process
JYK04_RS19625	COG0277	FAD linked oxidase domain protein
JYK04_RS19630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JYK04_RS19645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JYK04_RS19655	COG2252	PERMEase
JYK04_RS19680	COG0667	Aldo Keto reductase
JYK04_RS19695	COG2268	Band 7 protein
JYK04_RS19710	COG2814	Major facilitator Superfamily
JYK04_RS19720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JYK04_RS19725	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JYK04_RS19730	COG1278	Cold shock
JYK04_RS19780	COG1061	Type III restriction enzyme res subunit
JYK04_RS19800	COG3973	AAA domain
JYK04_RS19835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JYK04_RS19905	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS19910	COG1309	transcriptional regulator
JYK04_RS19920	COG0477	Major facilitator Superfamily
JYK04_RS19935	COG0745	RESPONSE REGULATOR receiver
JYK04_RS19970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JYK04_RS19975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JYK04_RS20000	COG0135	phosphoribosylanthranilate isomerase activity
JYK04_RS20025	COG0463	Glycosyl transferase, family 2
JYK04_RS20035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JYK04_RS20035	COG0561	phosphatase activity
JYK04_RS20045	COG2182	Extracellular solute-binding protein
JYK04_RS20050	COG1940	carbohydrate kinase activity
JYK04_RS20055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JYK04_RS20080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JYK04_RS20100	COG3290	protein histidine kinase activity
JYK04_RS20155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JYK04_RS20160	COG2188	Transcriptional regulator
JYK04_RS20250	COG3842	ATPase activity
JYK04_RS20260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JYK04_RS20270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JYK04_RS20275	COG0215	cysteine-tRNA ligase activity
JYK04_RS20280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JYK04_RS20285	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JYK04_RS20290	COG1329	Transcriptional regulator
JYK04_RS20305	COG5002	protein histidine kinase activity
JYK04_RS20340	COG0588	phosphoglycerate mutase activity
JYK04_RS20360	COG0438	transferase activity, transferring glycosyl groups
JYK04_RS20405	COG2890	protein-(glutamine-N5) methyltransferase activity
JYK04_RS20410	COG4552	Acetyltransferase involved in intracellular survival and related
JYK04_RS20420	COG1490	D-aminoacyl-tRNA deacylase activity
JYK04_RS20435	COG3485	protocatechuate 3,4-dioxygenase
JYK04_RS20465	COG2897	thiosulfate sulfurtransferase activity
JYK04_RS20485	COG0745	RESPONSE REGULATOR receiver
JYK04_RS20490	COG1609	Transcriptional regulator
JYK04_RS20500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JYK04_RS20505	COG0745	RESPONSE REGULATOR receiver
JYK04_RS20515	COG0823	Involved in the tonB-independent uptake of proteins
JYK04_RS20525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JYK04_RS20530	COG0737	Belongs to the 5'-nucleotidase family
JYK04_RS20535	COG0456	acetyltransferase
JYK04_RS20570	COG0306	phosphate transporter
JYK04_RS20580	COG1937	Protein conserved in bacteria
JYK04_RS20600	COG0671	phosphoesterase, PA-phosphatase related
JYK04_RS20605	COG0739	heme binding
JYK04_RS20605	COG0741	lytic transglycosylase activity
JYK04_RS20605	COG1196	nuclear chromosome segregation
JYK04_RS20620	COG1280	lysine exporter protein (LysE YggA)
JYK04_RS20625	COG1357	PFAM Pentapeptide repeats (8 copies)
JYK04_RS20630	COG2945	thiolester hydrolase activity
JYK04_RS20630	COG0596	Alpha beta hydrolase
JYK04_RS20705	COG0604	alcohol dehydrogenase
JYK04_RS20755	COG1252	NADH dehydrogenase
JYK04_RS20800	COG0579	oxidoreductase
JYK04_RS20805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JYK04_RS20815	COG0741	lytic transglycosylase activity
JYK04_RS20815	COG0739	heme binding
JYK04_RS20815	COG1196	nuclear chromosome segregation
JYK04_RS20865	COG0535	radical SAM domain protein
JYK04_RS20915	COG0513	Belongs to the DEAD box helicase family
JYK04_RS20925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JYK04_RS20930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JYK04_RS20955	COG0785	Cytochrome C biogenesis protein
JYK04_RS20970	COG1643	Atp-dependent helicase
JYK04_RS21000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JYK04_RS21010	COG3119	arylsulfatase activity
JYK04_RS21030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JYK04_RS21035	COG0047	phosphoribosylformylglycinamidine synthase activity
JYK04_RS21040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JYK04_RS21060	COG1131	(ABC) transporter
JYK04_RS21075	COG2197	response regulator
JYK04_RS21085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JYK04_RS21100	COG0151	Belongs to the GarS family
JYK04_RS21170	COG0433	COG0433 Predicted ATPase
JYK04_RS21185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JYK04_RS21230	COG1191	sigma factor activity
JYK04_RS21260	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JYK04_RS21270	COG2205	protein histidine kinase activity
JYK04_RS21275	COG0745	RESPONSE REGULATOR receiver
JYK04_RS21295	COG1522	sequence-specific DNA binding
JYK04_RS21335	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS21340	COG1595	DNA-templated transcription, initiation
JYK04_RS21355	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS21365	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS21380	COG0577	efflux transmembrane transporter activity
JYK04_RS21380	COG1136	(ABC) transporter
JYK04_RS21405	COG2855	membrane
JYK04_RS21420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JYK04_RS21435	COG0653	protein targeting
JYK04_RS21455	COG0006	proline dipeptidase activity
JYK04_RS21485	COG2372	response to copper ion
JYK04_RS21490	COG2837	iron assimilation
JYK04_RS21500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JYK04_RS21505	COG0561	phosphatase activity
JYK04_RS21520	COG2197	response regulator
JYK04_RS21545	COG1131	(ABC) transporter
JYK04_RS21565	COG0789	Transcriptional regulator
JYK04_RS21575	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
JYK04_RS21585	COG0561	phosphatase activity
JYK04_RS21595	COG4988	ABC transporter
JYK04_RS21600	COG1294	oxidase, subunit
JYK04_RS21605	COG1271	oxidase subunit
JYK04_RS21615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JYK04_RS21620	COG1609	Transcriptional regulator
JYK04_RS21635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JYK04_RS21660	COG0662	Cupin 2, conserved barrel domain protein
JYK04_RS21665	COG1950	PFAM Membrane protein of
JYK04_RS21670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JYK04_RS21675	COG0626	cystathionine gamma-synthase activity
JYK04_RS21685	COG0494	nUDIX hydrolase
JYK04_RS21705	COG0456	acetyltransferase
JYK04_RS21720	COG0305	Participates in initiation and elongation during chromosome replication
JYK04_RS21730	COG0359	binds to the 23S rRNA
JYK04_RS21735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JYK04_RS21740	COG0629	single-stranded DNA binding
JYK04_RS21745	COG0360	Binds together with S18 to 16S ribosomal RNA
JYK04_RS21770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JYK04_RS21780	COG1260	myo-inositol-1-phosphate synthase
JYK04_RS21790	COG0617	tRNA 3'-terminal CCA addition
JYK04_RS21805	COG2815	serine threonine protein kinase
JYK04_RS21805	COG0515	serine threonine protein kinase
JYK04_RS21810	COG1595	DNA-templated transcription, initiation
JYK04_RS21820	COG0492	ferredoxin-NADP+ reductase activity
JYK04_RS21825	COG3118	belongs to the thioredoxin family
JYK04_RS21840	COG1192	Involved in chromosome partitioning
JYK04_RS21845	COG0357	Ribosomal RNA small subunit methyltransferase G
JYK04_RS21855	COG0706	membrane insertase activity
JYK04_RS21860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JYK04_RS21865	COG0594	ribonuclease P activity
JYK04_RS21870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JYK04_RS21875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JYK04_RS21880	COG0592	DNA-directed DNA polymerase activity
JYK04_RS21885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JYK04_RS21890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JYK04_RS21895	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JYK04_RS21905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JYK04_RS21930	COG0515	serine threonine protein kinase
JYK04_RS21970	COG3903	Transcriptional regulator
JYK04_RS21970	COG3629	intracellular signal transduction
JYK04_RS21995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JYK04_RS22020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JYK04_RS22025	COG1834	amidinotransferase
JYK04_RS22040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JYK04_RS22040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JYK04_RS22050	COG0151	Belongs to the GarS family
JYK04_RS22055	COG1834	amidinotransferase
JYK04_RS22090	COG3903	Transcriptional regulator
JYK04_RS22090	COG3629	intracellular signal transduction
JYK04_RS22095	COG3903	Transcriptional regulator
JYK04_RS22095	COG3629	intracellular signal transduction
JYK04_RS22125	COG0457	Tetratricopeptide repeat
JYK04_RS22125	COG0705	Rhomboid family
JYK04_RS22140	COG3764	Sortase (surface protein transpeptidase)
JYK04_RS22155	COG3764	Sortase (surface protein transpeptidase)
JYK04_RS22160	COG3764	Sortase (surface protein transpeptidase)
JYK04_RS22165	COG0515	serine threonine protein kinase
JYK04_RS22170	COG0768	penicillin binding
JYK04_RS22185	COG1716	ATPase activity
JYK04_RS22190	COG1716	ATPase activity
JYK04_RS22205	COG4585	Histidine kinase
JYK04_RS22210	COG2197	response regulator
JYK04_RS22235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JYK04_RS22240	COG2151	metal-sulfur cluster biosynthetic enzyme
JYK04_RS22245	COG3396	Phenylacetate-CoA oxygenase
JYK04_RS22250	COG3460	Phenylacetate-CoA oxygenase
JYK04_RS22255	COG3396	Phenylacetate-CoA oxygenase
JYK04_RS22285	COG1250	3-hydroxyacyl-CoA dehydrogenase
JYK04_RS22290	COG1309	transcriptional regulator
JYK04_RS22300	COG1522	sequence-specific DNA binding
JYK04_RS22320	COG3321	synthase
JYK04_RS22320	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS22320	COG0604	alcohol dehydrogenase
JYK04_RS22325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JYK04_RS22335	COG0746	molybdenum cofactor guanylyltransferase activity
JYK04_RS22350	COG1136	(ABC) transporter
JYK04_RS22350	COG4591	ABC-type transport system involved in lipoprotein release permease component
JYK04_RS22365	COG0515	serine threonine protein kinase
JYK04_RS22370	COG0515	serine threonine protein kinase
JYK04_RS22390	COG0022	dehydrogenase e1 component
JYK04_RS22395	COG0508	dehydrogenase complex catalyzes the overall conversion of
JYK04_RS22430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS22460	COG2271	Major facilitator Superfamily
JYK04_RS22515	COG1362	aminopeptidase activity
JYK04_RS22530	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS22565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JYK04_RS22580	COG2205	protein histidine kinase activity
JYK04_RS22590	COG1289	transmembrane transporter activity
JYK04_RS22685	COG1278	Cold shock
JYK04_RS22705	COG0277	FAD linked oxidase domain protein
JYK04_RS22720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JYK04_RS22745	COG0702	epimerase
JYK04_RS22770	COG2267	carboxylic ester hydrolase activity
JYK04_RS22800	COG1937	Protein conserved in bacteria
JYK04_RS22810	COG0730	response to heat
JYK04_RS22815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JYK04_RS22820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYK04_RS22820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JYK04_RS22835	COG3209	COG3209 Rhs family protein
JYK04_RS22870	COG2124	cytochrome p450
JYK04_RS22875	COG0667	Aldo Keto reductase
JYK04_RS22885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JYK04_RS22905	COG0367	asparagine synthase
JYK04_RS22920	COG2264	protein methyltransferase activity
JYK04_RS22935	COG1131	(ABC) transporter
JYK04_RS22950	COG4585	Histidine kinase
JYK04_RS22955	COG2197	response regulator
JYK04_RS22970	COG0477	Major facilitator Superfamily
JYK04_RS23080	COG0513	Belongs to the DEAD box helicase family
JYK04_RS23085	COG1278	Cold shock
JYK04_RS23095	COG0717	Belongs to the dCTP deaminase family
JYK04_RS23125	COG0443	Heat shock 70 kDa protein
JYK04_RS23130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JYK04_RS23135	COG0484	heat shock protein binding
JYK04_RS23140	COG0789	Transcriptional regulator
JYK04_RS23160	COG0542	response to heat
JYK04_RS23205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JYK04_RS23220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JYK04_RS23225	COG0191	fructose-bisphosphate aldolase activity
JYK04_RS23270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JYK04_RS23285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JYK04_RS23290	COG0346	lactoylglutathione lyase activity
JYK04_RS23305	COG1131	(ABC) transporter
JYK04_RS23310	COG3559	Exporter of polyketide antibiotics
JYK04_RS23315	COG2124	cytochrome p450
JYK04_RS23320	COG2197	response regulator
JYK04_RS23330	COG2197	response regulator
JYK04_RS23335	COG4585	Histidine kinase
JYK04_RS23355	COG0693	protein deglycase activity
JYK04_RS23360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JYK04_RS23380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JYK04_RS23385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JYK04_RS23405	COG1595	DNA-templated transcription, initiation
JYK04_RS23430	COG0402	S-adenosylhomocysteine deaminase activity
JYK04_RS23450	COG1846	Transcriptional regulator
JYK04_RS23475	COG1408	metallophosphoesterase
JYK04_RS23485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JYK04_RS23495	COG0003	Pfam Anion-transporting ATPase
JYK04_RS23520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYK04_RS23555	COG2267	carboxylic ester hydrolase activity
JYK04_RS23565	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JYK04_RS23570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JYK04_RS23635	COG1111	helicase
JYK04_RS23635	COG1205	dead DEAH box helicase
JYK04_RS23640	COG1366	Belongs to the anti-sigma-factor antagonist family
JYK04_RS23650	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JYK04_RS23660	COG2890	protein-(glutamine-N5) methyltransferase activity
JYK04_RS23665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JYK04_RS23665	COG1754	DNA topoisomerase type I activity
JYK04_RS23670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JYK04_RS23675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JYK04_RS23690	COG1309	transcriptional regulator
JYK04_RS23715	COG0583	DNA-binding transcription factor activity
JYK04_RS23720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JYK04_RS23740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS23770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS23780	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JYK04_RS23830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JYK04_RS23830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JYK04_RS23840	COG1733	regulation of RNA biosynthetic process
JYK04_RS23850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JYK04_RS23870	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS23875	COG0768	penicillin binding
JYK04_RS23880	COG2318	DinB family
JYK04_RS23900	COG0789	Transcriptional regulator
JYK04_RS23905	COG0586	Pfam SNARE associated Golgi protein
JYK04_RS23915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JYK04_RS23920	COG2027	D-alanyl-D-alanine carboxypeptidase
JYK04_RS23930	COG0037	tRNA processing
JYK04_RS23935	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JYK04_RS23945	COG0302	gtp cyclohydrolase
JYK04_RS23955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JYK04_RS23960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JYK04_RS23975	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JYK04_RS23975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JYK04_RS23990	COG1174	glycine betaine transport
JYK04_RS24000	COG1732	Glycine betaine
JYK04_RS24010	COG1309	transcriptional regulator
JYK04_RS24015	COG2084	Dehydrogenase
JYK04_RS24040	COG0649	NAD binding
JYK04_RS24055	COG2197	response regulator
JYK04_RS24075	COG0640	Transcriptional regulator
JYK04_RS24085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JYK04_RS24095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JYK04_RS24100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JYK04_RS24135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JYK04_RS24165	COG0739	heme binding
JYK04_RS24175	COG2205	protein histidine kinase activity
JYK04_RS24180	COG0745	RESPONSE REGULATOR receiver
JYK04_RS24190	COG1595	DNA-templated transcription, initiation
JYK04_RS24195	COG1194	a g-specific adenine glycosylase
JYK04_RS24205	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JYK04_RS24230	COG0248	Ppx GppA phosphatase
JYK04_RS24240	COG1082	Xylose isomerase domain protein TIM barrel
JYK04_RS24250	COG0129	dihydroxy-acid dehydratase activity
JYK04_RS24255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS24255	COG0515	serine threonine protein kinase
JYK04_RS24260	COG4991	sh3 domain protein
JYK04_RS24270	COG1129	ABC transporter
JYK04_RS24270	COG0842	Transport permease protein
JYK04_RS24280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JYK04_RS24285	COG0180	Tryptophanyl-tRNA synthetase
JYK04_RS24305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JYK04_RS24315	COG0123	including yeast histone deacetylase and acetoin utilization protein
JYK04_RS24365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JYK04_RS24370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JYK04_RS24375	COG0181	hydroxymethylbilane synthase activity
JYK04_RS24380	COG1648	precorrin-2 dehydrogenase activity
JYK04_RS24380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JYK04_RS24400	COG0113	porphobilinogen synthase activity
JYK04_RS24460	COG2771	luxR family
JYK04_RS24490	COG1136	(ABC) transporter
JYK04_RS24495	COG0577	efflux transmembrane transporter activity
JYK04_RS24530	COG0018	arginyl-trna synthetase
JYK04_RS24535	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
JYK04_RS24555	COG1690	Belongs to the RtcB family
JYK04_RS24585	COG1733	regulation of RNA biosynthetic process
JYK04_RS24590	COG0604	alcohol dehydrogenase
JYK04_RS24610	COG1136	(ABC) transporter
JYK04_RS24610	COG0577	efflux transmembrane transporter activity
JYK04_RS24615	COG0577	efflux transmembrane transporter activity
JYK04_RS24615	COG1136	(ABC) transporter
JYK04_RS24625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JYK04_RS24630	COG0406	alpha-ribazole phosphatase activity
JYK04_RS24645	COG1333	cytochrome c biogenesis protein
JYK04_RS24650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JYK04_RS24665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JYK04_RS24675	COG0109	protoheme IX farnesyltransferase activity
JYK04_RS24690	COG0163	prenyltransferase activity
JYK04_RS24705	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JYK04_RS24720	COG1301	dicarboxylic acid transport
JYK04_RS24755	COG0702	epimerase
JYK04_RS24780	COG1278	Cold shock
JYK04_RS24785	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JYK04_RS24790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS24790	COG0515	serine threonine protein kinase
JYK04_RS24795	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JYK04_RS24815	COG2226	methyltransferase
JYK04_RS24820	COG2066	Belongs to the glutaminase family
JYK04_RS24840	COG0577	efflux transmembrane transporter activity
JYK04_RS24845	COG0577	efflux transmembrane transporter activity
JYK04_RS24845	COG1136	(ABC) transporter
JYK04_RS24880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JYK04_RS24885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JYK04_RS24890	COG0649	NAD binding
JYK04_RS24900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JYK04_RS24905	COG1034	ATP synthesis coupled electron transport
JYK04_RS24910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JYK04_RS24915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JYK04_RS24920	COG0839	Belongs to the complex I subunit 6 family
JYK04_RS24925	COG0713	ATP synthesis coupled electron transport
JYK04_RS24930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JYK04_RS24940	COG1007	ATP synthesis coupled electron transport
JYK04_RS24950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JYK04_RS24960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JYK04_RS24975	COG2188	Transcriptional regulator
JYK04_RS24985	COG0561	phosphatase activity
JYK04_RS24990	COG2936	dipeptidyl-peptidase activity
JYK04_RS24995	COG0142	geranyltranstransferase activity
JYK04_RS25025	COG1013	pyruvate-flavodoxin oxidoreductase activity
JYK04_RS25030	COG0674	pyruvate-flavodoxin oxidoreductase activity
JYK04_RS25030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JYK04_RS25050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JYK04_RS25055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JYK04_RS25060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JYK04_RS25065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JYK04_RS25070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JYK04_RS25075	COG0839	Belongs to the complex I subunit 6 family
JYK04_RS25080	COG0713	ATP synthesis coupled electron transport
JYK04_RS25085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JYK04_RS25095	COG1007	ATP synthesis coupled electron transport
JYK04_RS25100	COG0501	Belongs to the peptidase M48B family
JYK04_RS25105	COG3304	Inner membrane component domain
JYK04_RS25120	COG0659	secondary active sulfate transmembrane transporter activity
JYK04_RS25125	COG1666	GTP binding
JYK04_RS25145	COG0702	epimerase
JYK04_RS25165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JYK04_RS25170	COG2030	dehydratase
JYK04_RS25185	COG0477	Major facilitator Superfamily
JYK04_RS25195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JYK04_RS25205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JYK04_RS25210	COG0436	Aminotransferase
JYK04_RS25220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JYK04_RS25230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JYK04_RS25235	COG0081	regulation of translation
JYK04_RS25250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JYK04_RS25255	COG0222	ribosome binding
JYK04_RS25260	COG0085	RNA polymerase activity
JYK04_RS25265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JYK04_RS25275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JYK04_RS25280	COG0049	tRNA binding
JYK04_RS25285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JYK04_RS25290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JYK04_RS25320	COG1216	Glycosyl transferase, family 2
JYK04_RS25340	COG0051	transcription antitermination factor activity, RNA binding
JYK04_RS25345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JYK04_RS25350	COG0088	Forms part of the polypeptide exit tunnel
JYK04_RS25355	COG0089	rRNA binding
JYK04_RS25360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JYK04_RS25365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JYK04_RS25370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JYK04_RS25375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JYK04_RS25380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JYK04_RS25385	COG0255	Belongs to the universal ribosomal protein uL29 family
JYK04_RS25390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JYK04_RS25395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JYK04_RS25400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JYK04_RS25405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JYK04_RS25410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JYK04_RS25415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JYK04_RS25420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JYK04_RS25425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JYK04_RS25430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JYK04_RS25440	COG0200	Binds to the 23S rRNA
JYK04_RS25450	COG0563	adenylate kinase activity
JYK04_RS25460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JYK04_RS25465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JYK04_RS25470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JYK04_RS25475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JYK04_RS25480	COG0202	RNA polymerase activity
JYK04_RS25485	COG0203	ribosomal protein L17
JYK04_RS25490	COG0101	tRNA pseudouridine synthase activity
JYK04_RS25495	COG0488	(ABC) transporter
JYK04_RS25505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JYK04_RS25510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JYK04_RS25515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JYK04_RS25525	COG1072	(Pantothenic acid kinase))
JYK04_RS25535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JYK04_RS25540	COG0736	holo-[acyl-carrier-protein] synthase activity
JYK04_RS25550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JYK04_RS25560	COG0802	atpase or kinase
JYK04_RS25585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JYK04_RS25600	COG0726	polysaccharide deacetylase
JYK04_RS25605	COG0726	polysaccharide deacetylase
JYK04_RS25620	COG1051	belongs to the nudix hydrolase family
JYK04_RS25625	COG2188	Transcriptional regulator
JYK04_RS25635	COG0772	Belongs to the SEDS family
JYK04_RS25640	COG2205	protein histidine kinase activity
JYK04_RS25645	COG0745	RESPONSE REGULATOR receiver
JYK04_RS25655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JYK04_RS25660	COG0459	protein refolding
JYK04_RS25670	COG4221	oxidoreductase activity
JYK04_RS25680	COG0583	DNA-binding transcription factor activity
JYK04_RS25690	COG2197	response regulator
JYK04_RS25695	COG1595	DNA-templated transcription, initiation
JYK04_RS25705	COG0516	GMP reductase activity
JYK04_RS25715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JYK04_RS25720	COG0515	serine threonine protein kinase
JYK04_RS25730	COG0515	serine threonine protein kinase
JYK04_RS25735	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS25755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JYK04_RS25755	COG0519	Catalyzes the synthesis of GMP from XMP
JYK04_RS25790	COG2197	response regulator
JYK04_RS25810	COG0640	Transcriptional regulator
JYK04_RS25830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS25830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS25845	COG0714	Associated with various cellular activities
JYK04_RS25855	COG3552	Protein containing von Willebrand factor type A (VWA) domain
JYK04_RS25860	COG0045	succinate-CoA ligase (ADP-forming) activity
JYK04_RS25890	COG0138	bifunctional purine biosynthesis protein purh
JYK04_RS25900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JYK04_RS25915	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS25920	COG0039	L-malate dehydrogenase activity
JYK04_RS25940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JYK04_RS25945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS25960	COG0754	glutathionylspermidine amidase activity
JYK04_RS25965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JYK04_RS25970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JYK04_RS25975	COG0180	Tryptophanyl-tRNA synthetase
JYK04_RS26000	COG1686	Belongs to the peptidase S11 family
JYK04_RS26010	COG1408	metallophosphoesterase
JYK04_RS26020	COG1309	transcriptional regulator
JYK04_RS26040	COG3795	YCII-related domain
JYK04_RS26045	COG4941	Belongs to the sigma-70 factor family
JYK04_RS26060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JYK04_RS26065	COG1053	succinate dehydrogenase
JYK04_RS26075	COG2009	succinate dehydrogenase
JYK04_RS26085	COG1595	DNA-templated transcription, initiation
JYK04_RS26100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS26100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS26115	COG1216	Glycosyl transferase, family 2
JYK04_RS26125	COG2089	acid synthase
JYK04_RS26135	COG1473	amidohydrolase
JYK04_RS26135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JYK04_RS26140	COG1744	ABC transporter substrate-binding protein PnrA-like
JYK04_RS26145	COG3845	ABC transporter
JYK04_RS26155	COG1079	Belongs to the binding-protein-dependent transport system permease family
JYK04_RS26195	COG2814	Major facilitator Superfamily
JYK04_RS26200	COG0583	DNA-binding transcription factor activity
JYK04_RS26220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JYK04_RS26265	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS26270	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS26295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JYK04_RS26310	COG1595	DNA-templated transcription, initiation
JYK04_RS26315	COG0745	RESPONSE REGULATOR receiver
JYK04_RS26320	COG2205	protein histidine kinase activity
JYK04_RS26330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JYK04_RS26350	COG1349	DNA-binding transcription factor activity
JYK04_RS26355	COG4770	biotin carboxylase activity
JYK04_RS26370	COG0424	maF-like protein
JYK04_RS26380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JYK04_RS26395	COG1024	Enoyl-CoA hydratase
JYK04_RS26405	COG2986	histidine ammonia-lyase
JYK04_RS26420	COG1376	ErfK ybiS ycfS ynhG family protein
JYK04_RS26435	COG1064	alcohol dehydrogenase
JYK04_RS26440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JYK04_RS26450	COG0501	Belongs to the peptidase M48B family
JYK04_RS26480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JYK04_RS26495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JYK04_RS26505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JYK04_RS26525	COG1331	Highly conserved protein containing a thioredoxin domain
JYK04_RS26540	COG0463	Glycosyl transferase, family 2
JYK04_RS26555	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
JYK04_RS26570	COG3853	Toxic anion resistance protein (TelA)
JYK04_RS26645	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JYK04_RS26655	COG1414	Transcriptional regulator
JYK04_RS26685	COG2894	cell division
JYK04_RS26735	COG2885	chlorophyll binding
JYK04_RS26745	COG1309	transcriptional regulator
JYK04_RS26770	COG0726	polysaccharide deacetylase
JYK04_RS26785	COG1653	transport
JYK04_RS26805	COG0667	Aldo Keto reductase
JYK04_RS26810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JYK04_RS26815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JYK04_RS26840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JYK04_RS26845	COG0450	alkyl hydroperoxide reductase
JYK04_RS26860	COG1136	(ABC) transporter
JYK04_RS26880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JYK04_RS26890	COG3557	Belongs to the UPF0374 family
JYK04_RS26895	COG0114	fumarate hydratase activity
JYK04_RS26930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JYK04_RS26930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JYK04_RS26960	COG0778	Nitroreductase
JYK04_RS26965	COG1722	exodeoxyribonuclease VII activity
JYK04_RS26970	COG1570	exodeoxyribonuclease VII activity
JYK04_RS26980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JYK04_RS26995	COG0012	GTP binding
JYK04_RS27085	COG0697	spore germination
JYK04_RS27090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JYK04_RS27135	COG1842	Phage shock protein A
JYK04_RS27150	COG1053	succinate dehydrogenase
JYK04_RS27170	COG1217	gtp-binding protein TYPA
JYK04_RS27175	COG4166	transmembrane transport
JYK04_RS27180	COG0601	transmembrane transport
JYK04_RS27185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYK04_RS27195	COG4608	Belongs to the ABC transporter superfamily
JYK04_RS27205	COG4166	transmembrane transport
JYK04_RS27210	COG0601	transmembrane transport
JYK04_RS27215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYK04_RS27220	COG0444	Belongs to the ABC transporter superfamily
JYK04_RS27225	COG4608	Belongs to the ABC transporter superfamily
JYK04_RS27235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JYK04_RS27250	COG1131	(ABC) transporter
JYK04_RS27260	COG4585	Histidine kinase
JYK04_RS27265	COG2197	response regulator
JYK04_RS27300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JYK04_RS27305	COG1611	Belongs to the LOG family
JYK04_RS27310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JYK04_RS27320	COG0519	Catalyzes the synthesis of GMP from XMP
JYK04_RS27325	COG1024	Enoyl-CoA hydratase
JYK04_RS27345	COG1595	DNA-templated transcription, initiation
JYK04_RS27355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JYK04_RS27360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JYK04_RS27395	COG0598	Magnesium transport protein CorA
JYK04_RS27415	COG2095	MarC family integral membrane protein
JYK04_RS27425	COG2267	carboxylic ester hydrolase activity
JYK04_RS27540	COG0210	DNA helicase
JYK04_RS27545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JYK04_RS27605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JYK04_RS27660	COG3480	Lon protease (S16) C-terminal proteolytic domain
JYK04_RS27670	COG1615	UPF0182 protein
JYK04_RS27685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS27705	COG0753	catalase activity
JYK04_RS27715	COG0483	inositol monophosphate 1-phosphatase activity
JYK04_RS27725	COG2076	Multidrug Resistance protein
JYK04_RS27735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JYK04_RS27745	COG2135	peptidase activity
JYK04_RS27755	COG1595	DNA-templated transcription, initiation
JYK04_RS27760	COG5662	AntiSigma factor
JYK04_RS27765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JYK04_RS27765	COG2199	diguanylate cyclase activity
JYK04_RS27785	COG0242	peptide deformylase activity
JYK04_RS27820	COG1966	Carbon starvation protein
JYK04_RS27825	COG2188	Transcriptional regulator
JYK04_RS27830	COG2182	Extracellular solute-binding protein
JYK04_RS27835	COG1175	transmembrane transport
JYK04_RS27840	COG0395	ABC-type sugar transport system, permease component
JYK04_RS27845	COG1472	Belongs to the glycosyl hydrolase 3 family
JYK04_RS27850	COG0363	glucosamine-6-phosphate deaminase activity
JYK04_RS27860	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS27865	COG1309	transcriptional regulator
JYK04_RS27910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JYK04_RS27925	COG1017	nitric oxide dioxygenase activity
JYK04_RS27925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JYK04_RS27930	COG1959	2 iron, 2 sulfur cluster binding
JYK04_RS27935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JYK04_RS27940	COG0142	geranyltranstransferase activity
JYK04_RS27960	COG5640	endopeptidase activity
JYK04_RS28005	COG0604	alcohol dehydrogenase
JYK04_RS28010	COG0281	malic enzyme
JYK04_RS28020	COG0765	amino acid transport
JYK04_RS28025	COG1126	abc transporter atp-binding protein
JYK04_RS28175	COG0567	Dehydrogenase, E1 component
JYK04_RS28175	COG0508	dehydrogenase complex catalyzes the overall conversion of
JYK04_RS28180	COG2205	protein histidine kinase activity
JYK04_RS28185	COG0745	RESPONSE REGULATOR receiver
JYK04_RS28200	COG3415	Transposase
JYK04_RS28200	COG2801	Transposase and inactivated derivatives
JYK04_RS28215	COG2897	thiosulfate sulfurtransferase activity
JYK04_RS28225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JYK04_RS28240	COG5002	protein histidine kinase activity
JYK04_RS28265	COG0791	NLP P60 protein
JYK04_RS28265	COG1388	LysM domain
JYK04_RS28265	COG3103	Sh3 type 3 domain protein
JYK04_RS28305	COG0772	Belongs to the SEDS family
JYK04_RS28335	COG2205	protein histidine kinase activity
JYK04_RS28355	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
JYK04_RS28360	COG1793	dna ligase
JYK04_RS28360	COG3285	dna ligase
JYK04_RS28390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JYK04_RS28390	COG3608	succinylglutamate desuccinylase aspartoacylase
JYK04_RS28415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JYK04_RS28415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JYK04_RS28420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JYK04_RS28420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JYK04_RS28510	COG0745	RESPONSE REGULATOR receiver
JYK04_RS28515	COG0018	arginyl-trna synthetase
JYK04_RS28520	COG0019	diaminopimelate decarboxylase activity
JYK04_RS28525	COG0460	homoserine dehydrogenase
JYK04_RS28530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JYK04_RS28535	COG0083	homoserine kinase activity
JYK04_RS28545	COG1316	TRANSCRIPTIONal
JYK04_RS28550	COG0254	rRNA binding
JYK04_RS28555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JYK04_RS28560	COG2890	protein-(glutamine-N5) methyltransferase activity
JYK04_RS28570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JYK04_RS28575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JYK04_RS28595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JYK04_RS28600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JYK04_RS28605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JYK04_RS28610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JYK04_RS28615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JYK04_RS28620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JYK04_RS28625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JYK04_RS28640	COG2197	response regulator
JYK04_RS28660	COG1250	3-hydroxyacyl-CoA dehydrogenase
JYK04_RS28675	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
JYK04_RS28730	COG0183	Belongs to the thiolase family
JYK04_RS28825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS28825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS28840	COG3118	belongs to the thioredoxin family
JYK04_RS28875	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JYK04_RS28880	COG0857	belongs to the CobB CobQ family
JYK04_RS28880	COG0280	phosphate acetyltransferase
JYK04_RS28885	COG0205	6-phosphofructokinase activity
JYK04_RS28900	COG3118	belongs to the thioredoxin family
JYK04_RS28915	COG0366	Alpha amylase catalytic
JYK04_RS28920	COG0366	Alpha amylase catalytic
JYK04_RS28935	COG0058	SHG alpha-glucan phosphorylase activity
JYK04_RS28960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JYK04_RS28965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JYK04_RS28970	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
JYK04_RS29010	COG0489	protein tyrosine kinase activity
JYK04_RS29015	COG0297	glycogen (starch) synthase activity
JYK04_RS29115	COG1760	l-serine dehydratase
JYK04_RS29120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JYK04_RS29125	COG0509	glycine decarboxylation via glycine cleavage system
JYK04_RS29130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JYK04_RS29150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYK04_RS29155	COG0747	negative chemotaxis
JYK04_RS29165	COG0444	Belongs to the ABC transporter superfamily
JYK04_RS29170	COG4608	Belongs to the ABC transporter superfamily
JYK04_RS29175	COG2860	membrane
JYK04_RS29195	COG0482	sulfurtransferase activity
JYK04_RS29245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JYK04_RS29255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JYK04_RS29260	COG0154	amidase activity
JYK04_RS29270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JYK04_RS29280	COG2815	serine threonine protein kinase
JYK04_RS29280	COG0515	serine threonine protein kinase
JYK04_RS29295	COG1132	(ABC) transporter
JYK04_RS29295	COG2375	cellular response to nickel ion
JYK04_RS29305	COG2318	DinB family
JYK04_RS29320	COG2409	Drug exporters of the RND superfamily
JYK04_RS29325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JYK04_RS29340	COG2197	response regulator
JYK04_RS29350	COG2133	pyrroloquinoline quinone binding
JYK04_RS29355	COG0667	Aldo Keto reductase
JYK04_RS29375	COG0440	acetolactate synthase activity
JYK04_RS29380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JYK04_RS29385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JYK04_RS29400	COG0477	Major facilitator Superfamily
JYK04_RS29415	COG0506	proline dehydrogenase activity
JYK04_RS29420	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS29445	COG3511	phospholipase C
JYK04_RS29455	COG0583	DNA-binding transcription factor activity
JYK04_RS29460	COG0473	3-isopropylmalate dehydrogenase activity
JYK04_RS29465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JYK04_RS29470	COG0785	Cytochrome C biogenesis protein
JYK04_RS29480	COG0831	urea catabolic process
JYK04_RS29480	COG0832	Belongs to the urease beta subunit family
JYK04_RS29485	COG0804	urea catabolic process
JYK04_RS29490	COG2957	Belongs to the agmatine deiminase family
JYK04_RS29500	COG2801	Transposase and inactivated derivatives
JYK04_RS29500	COG3415	Transposase
JYK04_RS29510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JYK04_RS29520	COG2353	YceI-like domain
JYK04_RS29525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JYK04_RS29545	COG2018	Roadblock/LC7 domain
JYK04_RS29565	COG2018	Roadblock/LC7 domain
JYK04_RS29570	COG5002	protein histidine kinase activity
JYK04_RS29580	COG0179	Fumarylacetoacetate (FAA) hydrolase
JYK04_RS29585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JYK04_RS29590	COG1011	Hydrolase
JYK04_RS29625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JYK04_RS29630	COG0066	3-isopropylmalate dehydratase activity
JYK04_RS29640	COG0776	regulation of translation
JYK04_RS29645	COG1920	GTP binding
JYK04_RS29655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JYK04_RS29660	COG1181	Belongs to the D-alanine--D-alanine ligase family
JYK04_RS29680	COG0351	phosphomethylpyrimidine kinase
JYK04_RS29685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JYK04_RS29690	COG1461	Dihydroxyacetone kinase
JYK04_RS29700	COG0742	ribosomal rna small subunit methyltransferase
JYK04_RS29705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JYK04_RS29720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JYK04_RS29725	COG0571	ribonuclease III activity
JYK04_RS29730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JYK04_RS29735	COG1733	regulation of RNA biosynthetic process
JYK04_RS29750	COG1254	Belongs to the acylphosphatase family
JYK04_RS29760	COG1196	nuclear chromosome segregation
JYK04_RS29765	COG0477	Major facilitator Superfamily
JYK04_RS29805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JYK04_RS29815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JYK04_RS29825	COG0442	prolyl-tRNA aminoacylation
JYK04_RS29835	COG0228	four-way junction DNA binding
JYK04_RS29840	COG1837	Belongs to the UPF0109 family
JYK04_RS29845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JYK04_RS29850	COG0336	Belongs to the RNA methyltransferase TrmD family
JYK04_RS29855	COG0335	large ribosomal subunit rRNA binding
JYK04_RS29865	COG0681	Belongs to the peptidase S26 family
JYK04_RS29890	COG0792	nuclease activity
JYK04_RS29995	COG1074	ATP-dependent DNA helicase activity
JYK04_RS30125	COG1191	sigma factor activity
JYK04_RS30140	COG0052	Belongs to the universal ribosomal protein uS2 family
JYK04_RS30145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JYK04_RS30150	COG0528	UMP kinase activity
JYK04_RS30155	COG0233	cytoplasmic translational termination
JYK04_RS30165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JYK04_RS30180	COG3842	ATPase activity
JYK04_RS30225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JYK04_RS30235	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS30255	COG2197	response regulator
JYK04_RS30260	COG4585	Histidine kinase
JYK04_RS30270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JYK04_RS30295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JYK04_RS30300	COG3842	ATPase activity
JYK04_RS30305	COG1176	ABC-type spermidine putrescine transport system, permease component I
JYK04_RS30310	COG1177	transmembrane transport
JYK04_RS30315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JYK04_RS30345	COG2508	Transcriptional regulator
JYK04_RS30350	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS30365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JYK04_RS30370	COG0750	zinc metalloprotease
JYK04_RS30375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JYK04_RS30390	COG0442	prolyl-tRNA aminoacylation
JYK04_RS30395	COG0330	HflC and HflK could
JYK04_RS30415	COG0779	Required for maturation of 30S ribosomal subunits
JYK04_RS30430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JYK04_RS30440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JYK04_RS30445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JYK04_RS30460	COG0455	bacterial-type flagellum organization
JYK04_RS30480	COG1404	Belongs to the peptidase S8 family
JYK04_RS30500	COG1674	ftsk spoiiie
JYK04_RS30510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JYK04_RS30515	COG1185	polyribonucleotide nucleotidyltransferase activity
JYK04_RS30520	COG0612	Peptidase, M16
JYK04_RS30525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JYK04_RS30545	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
JYK04_RS30550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JYK04_RS30555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JYK04_RS30585	COG2770	Histidine kinase
JYK04_RS30585	COG2208	phosphoserine phosphatase activity
JYK04_RS30590	COG2205	protein histidine kinase activity
JYK04_RS30590	COG4999	Histidine kinase
JYK04_RS30590	COG3437	response regulator, receiver
JYK04_RS30590	COG3850	Histidine kinase
JYK04_RS30600	COG1674	ftsk spoiiie
JYK04_RS30610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JYK04_RS30620	COG1058	Belongs to the CinA family
JYK04_RS30620	COG1546	Belongs to the CinA family
JYK04_RS30625	COG1396	sequence-specific DNA binding
JYK04_RS30630	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS30635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JYK04_RS30645	COG1201	RNA secondary structure unwinding
JYK04_RS30650	COG1917	Cupin 2, conserved barrel domain protein
JYK04_RS30650	COG2207	Transcriptional regulator
JYK04_RS30685	COG2226	methyltransferase
JYK04_RS30705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JYK04_RS30735	COG0765	amino acid transport
JYK04_RS30740	COG0765	amino acid transport
JYK04_RS30745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JYK04_RS30750	COG1126	abc transporter atp-binding protein
JYK04_RS30760	COG2205	protein histidine kinase activity
JYK04_RS30780	COG1609	Transcriptional regulator
JYK04_RS30795	COG0583	DNA-binding transcription factor activity
JYK04_RS30805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JYK04_RS30825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JYK04_RS30835	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JYK04_RS30840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JYK04_RS30850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JYK04_RS30885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JYK04_RS30890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JYK04_RS30895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JYK04_RS30950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JYK04_RS30995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JYK04_RS31020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JYK04_RS31025	COG4565	transcriptional regulatory protein
JYK04_RS31030	COG3290	protein histidine kinase activity
JYK04_RS31050	COG3629	intracellular signal transduction
JYK04_RS31050	COG3903	Transcriptional regulator
JYK04_RS31060	COG0372	Belongs to the citrate synthase family
JYK04_RS31075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JYK04_RS31080	COG0612	Peptidase, M16
JYK04_RS31095	COG1802	Transcriptional regulator
JYK04_RS31100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JYK04_RS31120	COG1435	thymidine kinase activity
JYK04_RS31135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JYK04_RS31175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JYK04_RS31180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYK04_RS31185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JYK04_RS31225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JYK04_RS31240	COG0745	RESPONSE REGULATOR receiver
JYK04_RS31245	COG2205	protein histidine kinase activity
JYK04_RS31270	COG0756	dUTP diphosphatase activity
JYK04_RS31305	COG0569	domain protein
JYK04_RS31310	COG0531	amino acid
JYK04_RS31315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JYK04_RS31325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JYK04_RS31335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JYK04_RS31340	COG2124	cytochrome p450
JYK04_RS31405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS31405	COG0515	serine threonine protein kinase
JYK04_RS31425	COG0252	asparaginase activity
JYK04_RS31450	COG1940	carbohydrate kinase activity
JYK04_RS31460	COG0431	NADPH-dependent FMN reductase
JYK04_RS31475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JYK04_RS31480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS31485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JYK04_RS31505	COG1799	cell septum assembly
JYK04_RS31535	COG2040	homocysteine
JYK04_RS31545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JYK04_RS31555	COG2235	arginine
JYK04_RS31560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JYK04_RS31570	COG1024	Enoyl-CoA hydratase
JYK04_RS31635	COG0583	DNA-binding transcription factor activity
JYK04_RS31645	COG0006	proline dipeptidase activity
JYK04_RS31655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JYK04_RS31675	COG3938	Belongs to the proline racemase family
JYK04_RS31725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYK04_RS31735	COG0444	Belongs to the ABC transporter superfamily
JYK04_RS31740	COG4608	Belongs to the ABC transporter superfamily
JYK04_RS31790	COG1595	DNA-templated transcription, initiation
JYK04_RS31815	COG0494	nUDIX hydrolase
JYK04_RS31825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JYK04_RS31830	COG1846	Transcriptional regulator
JYK04_RS31835	COG0596	Alpha beta hydrolase
JYK04_RS31850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JYK04_RS31855	COG1653	transport
JYK04_RS31860	COG1175	transmembrane transport
JYK04_RS31865	COG0395	ABC-type sugar transport system, permease component
JYK04_RS31880	COG1940	carbohydrate kinase activity
JYK04_RS31885	COG4213	ABC transporter substrate-binding protein
JYK04_RS31895	COG4214	carbohydrate transport
JYK04_RS31900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JYK04_RS31905	COG0531	amino acid
JYK04_RS31915	COG1316	TRANSCRIPTIONal
JYK04_RS31920	COG1024	Enoyl-CoA hydratase
JYK04_RS31920	COG1250	3-hydroxyacyl-CoA dehydrogenase
JYK04_RS31925	COG0183	Belongs to the thiolase family
JYK04_RS31935	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JYK04_RS31950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JYK04_RS31955	COG0446	pyridine nucleotide-disulphide oxidoreductase
JYK04_RS31965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JYK04_RS31970	COG3253	May function as heme-dependent peroxidase
JYK04_RS31975	COG0596	Alpha beta hydrolase
JYK04_RS31985	COG3220	belongs to the UPF0276 family
JYK04_RS32075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JYK04_RS32080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JYK04_RS32130	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS32135	COG0463	Glycosyl transferase, family 2
JYK04_RS32140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS32145	COG3511	phospholipase C
JYK04_RS32165	COG0504	CTP synthase activity
JYK04_RS32170	COG0583	DNA-binding transcription factor activity
JYK04_RS32185	COG1716	ATPase activity
JYK04_RS32205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JYK04_RS32210	COG0583	DNA-binding transcription factor activity
JYK04_RS32280	COG0586	Pfam SNARE associated Golgi protein
JYK04_RS32290	COG0671	phosphoesterase, PA-phosphatase related
JYK04_RS32295	COG1968	undecaprenyl-diphosphatase activity
JYK04_RS32305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JYK04_RS32320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JYK04_RS32320	COG2080	2 iron, 2 sulfur cluster binding
JYK04_RS32325	COG3224	Antibiotic biosynthesis monooxygenase
JYK04_RS32335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JYK04_RS32340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JYK04_RS32360	COG0529	Catalyzes the synthesis of activated sulfate
JYK04_RS32365	COG0175	sulfate reduction
JYK04_RS32375	COG1846	Transcriptional regulator
JYK04_RS32375	COG0456	acetyltransferase
JYK04_RS32385	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS32425	COG2197	response regulator
JYK04_RS32435	COG1162	GTPase activity
JYK04_RS32470	COG1404	Belongs to the peptidase S8 family
JYK04_RS32500	COG0028	Belongs to the TPP enzyme family
JYK04_RS32520	COG1802	Transcriptional regulator
JYK04_RS32530	COG3835	regulator
JYK04_RS32550	COG2252	PERMEase
JYK04_RS32565	COG4552	Acetyltransferase involved in intracellular survival and related
JYK04_RS32705	COG0463	Glycosyl transferase, family 2
JYK04_RS32730	COG0463	Glycosyl transferase, family 2
JYK04_RS32745	COG0110	maltose O-acetyltransferase activity
JYK04_RS32755	COG1088	dTDP-glucose 4,6-dehydratase activity
JYK04_RS32805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JYK04_RS32805	COG1024	Enoyl-CoA hydratase
JYK04_RS32845	COG0375	protein maturation
JYK04_RS32850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JYK04_RS32855	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JYK04_RS32870	COG0309	Hydrogenase expression formation protein (HypE)
JYK04_RS32895	COG2197	response regulator
JYK04_RS32905	COG0515	serine threonine protein kinase
JYK04_RS32905	COG2815	serine threonine protein kinase
JYK04_RS32945	COG0598	Magnesium transport protein CorA
JYK04_RS32995	COG0598	Magnesium transport protein CorA
JYK04_RS33005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JYK04_RS33010	COG0386	Belongs to the glutathione peroxidase family
JYK04_RS33020	COG3960	tartronate-semialdehyde synthase activity
JYK04_RS33030	COG0753	catalase activity
JYK04_RS33035	COG2084	Dehydrogenase
JYK04_RS33040	COG3622	Belongs to the hyi family
JYK04_RS33060	COG2351	hydroxyisourate hydrolase activity
JYK04_RS33075	COG2233	PERMEase
JYK04_RS33105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JYK04_RS33120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS33130	COG2197	response regulator
JYK04_RS33135	COG4585	Histidine kinase
JYK04_RS33145	COG1136	(ABC) transporter
JYK04_RS33150	COG1414	Transcriptional regulator
JYK04_RS33155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JYK04_RS33160	COG4266	Belongs to the allantoicase family
JYK04_RS33165	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS33220	COG2188	Transcriptional regulator
JYK04_RS33275	COG0673	inositol 2-dehydrogenase activity
JYK04_RS33295	COG1940	carbohydrate kinase activity
JYK04_RS33320	COG1126	abc transporter atp-binding protein
JYK04_RS33330	COG1376	ErfK ybiS ycfS ynhG family protein
JYK04_RS33345	COG0745	RESPONSE REGULATOR receiver
JYK04_RS33350	COG2205	protein histidine kinase activity
JYK04_RS33370	COG0405	Gamma-glutamyltransferase
JYK04_RS33410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JYK04_RS33415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JYK04_RS33455	COG0483	inositol monophosphate 1-phosphatase activity
JYK04_RS33465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JYK04_RS33480	COG1448	Aminotransferase
JYK04_RS33505	COG1335	isochorismatase
JYK04_RS33510	COG1929	Belongs to the glycerate kinase type-1 family
JYK04_RS33515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JYK04_RS33525	COG0463	Glycosyl transferase, family 2
JYK04_RS33545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JYK04_RS33560	COG0688	phosphatidylethanolamine metabolic process
JYK04_RS33565	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS33580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS33580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JYK04_RS33585	COG0604	alcohol dehydrogenase
JYK04_RS33595	COG1250	3-hydroxyacyl-CoA dehydrogenase
JYK04_RS33625	COG2362	D-Aminopeptidase
JYK04_RS33630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JYK04_RS33655	COG0457	Tetratricopeptide repeat
JYK04_RS33710	COG0531	amino acid
JYK04_RS33730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JYK04_RS33740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JYK04_RS33775	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
JYK04_RS33775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS33780	COG2154	pterin-4-alpha-carbinolamine dehydratase
JYK04_RS33790	COG0656	L-ascorbic acid biosynthetic process
JYK04_RS33835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JYK04_RS33840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS33865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JYK04_RS33880	COG2197	response regulator
JYK04_RS33890	COG0515	serine threonine protein kinase
JYK04_RS33925	COG1486	melibiose metabolic process
JYK04_RS33940	COG0494	nUDIX hydrolase
JYK04_RS33960	COG1793	dna ligase
JYK04_RS33975	COG1846	Transcriptional regulator
JYK04_RS33980	COG2267	carboxylic ester hydrolase activity
JYK04_RS34025	COG0488	(ABC) transporter
JYK04_RS34065	COG1515	deoxyribonuclease V activity
JYK04_RS34070	COG3268	Saccharopine dehydrogenase
JYK04_RS34075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JYK04_RS34080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS34085	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS34090	COG0183	Belongs to the thiolase family
JYK04_RS34095	COG1024	Enoyl-CoA hydratase
JYK04_RS34095	COG1250	3-hydroxyacyl-CoA dehydrogenase
JYK04_RS34105	COG0789	Transcriptional regulator
JYK04_RS34110	COG1022	Amp-dependent synthetase and ligase
JYK04_RS34165	COG2183	response to ionizing radiation
JYK04_RS34180	COG0300	oxidoreductase activity
JYK04_RS34190	COG0488	(ABC) transporter
JYK04_RS34195	COG4977	sequence-specific DNA binding
JYK04_RS34205	COG1024	Enoyl-CoA hydratase
JYK04_RS34220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JYK04_RS34240	COG0371	Dehydrogenase
JYK04_RS34260	COG1134	teichoic acid transport
JYK04_RS34265	COG1562	ergosterol biosynthetic process
JYK04_RS34280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JYK04_RS34290	COG1657	PFAM Prenyltransferase squalene oxidase
JYK04_RS34320	COG2755	lipolytic protein G-D-S-L family
JYK04_RS34395	COG2814	Major facilitator Superfamily
JYK04_RS34420	COG0583	DNA-binding transcription factor activity
JYK04_RS34430	COG0598	Magnesium transport protein CorA
JYK04_RS34440	COG3152	Membrane
JYK04_RS34445	COG2838	Isocitrate dehydrogenase
JYK04_RS34470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JYK04_RS34480	COG0247	lactate metabolic process
JYK04_RS34485	COG1139	Iron-sulfur cluster binding protein
JYK04_RS34490	COG1556	Lactate utilization protein
JYK04_RS34495	COG0346	lactoylglutathione lyase activity
JYK04_RS34555	COG1132	(ABC) transporter
JYK04_RS34560	COG1132	(ABC) transporter
JYK04_RS34560	COG2375	cellular response to nickel ion
JYK04_RS34595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS34595	COG0515	serine threonine protein kinase
JYK04_RS34610	COG0831	urea catabolic process
JYK04_RS34610	COG0832	Belongs to the urease beta subunit family
JYK04_RS34615	COG0804	urea catabolic process
JYK04_RS34620	COG2957	Belongs to the agmatine deiminase family
JYK04_RS34625	COG0747	negative chemotaxis
JYK04_RS34635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYK04_RS34640	COG0444	Belongs to the ABC transporter superfamily
JYK04_RS34645	COG4608	Belongs to the ABC transporter superfamily
JYK04_RS34660	COG1132	(ABC) transporter
JYK04_RS34680	COG1231	oxidoreductase activity
JYK04_RS34690	COG1335	isochorismatase
JYK04_RS34705	COG1024	Enoyl-CoA hydratase
JYK04_RS34735	COG3511	phospholipase C
JYK04_RS34745	COG4106	trans-aconitate 2-methyltransferase activity
JYK04_RS34750	COG1819	glycosyl
JYK04_RS34755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JYK04_RS34765	COG0604	alcohol dehydrogenase
JYK04_RS34765	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS34765	COG3321	synthase
JYK04_RS34810	COG3345	alpha-galactosidase
JYK04_RS34825	COG0596	Alpha beta hydrolase
JYK04_RS34845	COG0589	response to stress
JYK04_RS34890	COG1653	transport
JYK04_RS34895	COG1175	transmembrane transport
JYK04_RS34900	COG0395	ABC-type sugar transport system, permease component
JYK04_RS34915	COG0446	pyridine nucleotide-disulphide oxidoreductase
JYK04_RS34915	COG1902	pentaerythritol trinitrate reductase activity
JYK04_RS34945	COG2409	Drug exporters of the RND superfamily
JYK04_RS34950	COG1846	Transcriptional regulator
JYK04_RS35030	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS35035	COG0789	Transcriptional regulator
JYK04_RS35055	COG0577	efflux transmembrane transporter activity
JYK04_RS35055	COG1136	(ABC) transporter
JYK04_RS35075	COG2080	2 iron, 2 sulfur cluster binding
JYK04_RS35075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JYK04_RS35080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JYK04_RS35085	COG3835	regulator
JYK04_RS35130	COG0668	transmembrane transport
JYK04_RS35150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JYK04_RS35170	COG0165	Argininosuccinate lyase
JYK04_RS35180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JYK04_RS35195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS35265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JYK04_RS35275	COG1063	alcohol dehydrogenase
JYK04_RS35310	COG0277	FAD linked oxidase domain protein
JYK04_RS35330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JYK04_RS35350	COG2267	carboxylic ester hydrolase activity
JYK04_RS35420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS35460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JYK04_RS35490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JYK04_RS35550	COG2813	Specifically methylates the guanine in position
JYK04_RS35560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JYK04_RS35635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JYK04_RS35645	COG0583	DNA-binding transcription factor activity
JYK04_RS35655	COG1053	succinate dehydrogenase
JYK04_RS35660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JYK04_RS35685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS35695	COG3360	Dodecin
JYK04_RS35700	COG2182	Extracellular solute-binding protein
JYK04_RS35715	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
JYK04_RS35720	COG0121	glutamine amidotransferase
JYK04_RS35725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JYK04_RS35730	COG3572	ergothioneine biosynthetic process
JYK04_RS35760	COG4122	O-methyltransferase activity
JYK04_RS35770	COG0596	Alpha beta hydrolase
JYK04_RS35780	COG1609	Transcriptional regulator
JYK04_RS35785	COG0183	Belongs to the thiolase family
JYK04_RS35795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JYK04_RS35800	COG4249	Peptidase C14 caspase catalytic subunit p20
JYK04_RS35800	COG2319	Wd-40 repeat
JYK04_RS35830	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JYK04_RS35860	COG2813	Specifically methylates the guanine in position
JYK04_RS35940	COG2801	Transposase and inactivated derivatives
JYK04_RS35950	COG0215	cysteine-tRNA ligase activity
JYK04_RS36010	COG1090	epimerase
JYK04_RS36095	COG2197	response regulator
JYK04_RS36100	COG4585	Histidine kinase
JYK04_RS36125	COG0604	alcohol dehydrogenase
JYK04_RS36125	COG3321	synthase
JYK04_RS36155	COG3321	synthase
JYK04_RS36155	COG0604	alcohol dehydrogenase
JYK04_RS36160	COG0604	alcohol dehydrogenase
JYK04_RS36160	COG3321	synthase
JYK04_RS36175	COG1131	(ABC) transporter
JYK04_RS36205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JYK04_RS36215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JYK04_RS36250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYK04_RS36270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JYK04_RS36280	COG1278	Cold shock
JYK04_RS36285	COG0513	Belongs to the DEAD box helicase family
JYK04_RS36295	COG0596	Alpha beta hydrolase
JYK04_RS36315	COG4677	pectinesterase activity
JYK04_RS36320	COG1595	DNA-templated transcription, initiation
JYK04_RS36430	COG2070	2-Nitropropane dioxygenase
JYK04_RS36450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JYK04_RS36465	COG1940	carbohydrate kinase activity
JYK04_RS36470	COG1063	alcohol dehydrogenase
JYK04_RS36480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JYK04_RS36490	COG0640	Transcriptional regulator
JYK04_RS36500	COG2072	flavoprotein involved in K transport
JYK04_RS36545	COG0640	Transcriptional regulator
JYK04_RS36560	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS36575	COG3246	L-lysine catabolic process to acetate
JYK04_RS36585	COG2175	clavaminate synthase activity
JYK04_RS36590	COG0477	Major facilitator Superfamily
JYK04_RS36600	COG4106	trans-aconitate 2-methyltransferase activity
JYK04_RS36630	COG1864	DNA RNA non-specific endonuclease
JYK04_RS36630	COG3591	Belongs to the peptidase S1B family
JYK04_RS36635	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
JYK04_RS36665	COG2326	polyphosphate kinase activity
JYK04_RS36690	COG0745	RESPONSE REGULATOR receiver
JYK04_RS36725	COG0598	Magnesium transport protein CorA
JYK04_RS36750	COG1366	Belongs to the anti-sigma-factor antagonist family
JYK04_RS36750	COG2172	sigma factor antagonist activity
JYK04_RS36750	COG2208	phosphoserine phosphatase activity
JYK04_RS36760	COG4552	Acetyltransferase involved in intracellular survival and related
JYK04_RS36775	COG0515	serine threonine protein kinase
JYK04_RS36825	COG3629	intracellular signal transduction
JYK04_RS36825	COG3903	Transcriptional regulator
JYK04_RS36855	COG0288	reversible hydration of carbon dioxide
JYK04_RS36890	COG3387	PFAM Glycoside hydrolase 15-related
JYK04_RS36900	COG0110	maltose O-acetyltransferase activity
JYK04_RS36910	COG1271	oxidase subunit
JYK04_RS36915	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS36930	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
JYK04_RS36940	COG2274	protein secretion by the type I secretion system
JYK04_RS36970	COG0514	ATP-dependent DNA helicase (RecQ)
JYK04_RS36980	COG0604	alcohol dehydrogenase
JYK04_RS37025	COG1764	response to oxidative stress
JYK04_RS37040	COG3864	Putative metallopeptidase domain
JYK04_RS37070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS37075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS37080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JYK04_RS37090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JYK04_RS37100	COG2249	NAD(P)H dehydrogenase (quinone) activity
JYK04_RS37120	COG3226	Transcriptional regulator
JYK04_RS37145	COG0583	DNA-binding transcription factor activity
JYK04_RS37170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JYK04_RS37175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYK04_RS37180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JYK04_RS37185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JYK04_RS37195	COG3845	ABC transporter
JYK04_RS37240	COG1686	Belongs to the peptidase S11 family
JYK04_RS37245	COG0596	Alpha beta hydrolase
JYK04_RS37250	COG1309	transcriptional regulator
JYK04_RS37275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JYK04_RS37325	COG0590	tRNA wobble adenosine to inosine editing
JYK04_RS37350	COG2326	polyphosphate kinase activity
JYK04_RS37365	COG1902	pentaerythritol trinitrate reductase activity
JYK04_RS37385	COG4941	Belongs to the sigma-70 factor family
JYK04_RS37390	COG3795	YCII-related domain
JYK04_RS37415	COG0477	Major facilitator Superfamily
JYK04_RS37445	COG0583	DNA-binding transcription factor activity
JYK04_RS37485	COG2226	methyltransferase
JYK04_RS37490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JYK04_RS37530	COG0596	Alpha beta hydrolase
JYK04_RS37555	COG4221	oxidoreductase activity
JYK04_RS37570	COG2197	response regulator
JYK04_RS37575	COG1024	Enoyl-CoA hydratase
JYK04_RS37595	COG0492	ferredoxin-NADP+ reductase activity
JYK04_RS37610	COG1136	(ABC) transporter
JYK04_RS37610	COG4591	ABC-type transport system involved in lipoprotein release permease component
JYK04_RS37625	COG0577	efflux transmembrane transporter activity
JYK04_RS37625	COG1136	(ABC) transporter
JYK04_RS37660	COG1609	Transcriptional regulator
JYK04_RS37665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JYK04_RS37715	COG0725	ABC transporter, periplasmic molybdate-binding protein
JYK04_RS37735	COG2226	methyltransferase
JYK04_RS37745	COG0243	molybdopterin cofactor binding
JYK04_RS37805	COG1335	isochorismatase
JYK04_RS37810	COG2259	Doxx family
JYK04_RS37815	COG2267	carboxylic ester hydrolase activity
JYK04_RS37825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JYK04_RS37850	COG2837	iron assimilation
JYK04_RS37875	COG4221	oxidoreductase activity
JYK04_RS37905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JYK04_RS37920	COG0277	FAD linked oxidase domain protein
JYK04_RS37925	COG1309	transcriptional regulator
JYK04_RS37945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JYK04_RS37970	COG1172	Belongs to the binding-protein-dependent transport system permease family
JYK04_RS37975	COG1129	ABC transporter
JYK04_RS37980	COG3284	Transcriptional regulator
JYK04_RS38025	COG2409	Drug exporters of the RND superfamily
JYK04_RS38030	COG5002	protein histidine kinase activity
JYK04_RS38035	COG0745	RESPONSE REGULATOR receiver
JYK04_RS38050	COG1024	Enoyl-CoA hydratase
JYK04_RS38055	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS38075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JYK04_RS38085	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
JYK04_RS38100	COG2909	trisaccharide binding
JYK04_RS38150	COG4733	cellulase activity
JYK04_RS38150	COG5297	Belongs to the glycosyl hydrolase family 6
JYK04_RS38180	COG3851	Histidine kinase
JYK04_RS38185	COG2197	response regulator
JYK04_RS38235	COG0393	Putative heavy-metal-binding
JYK04_RS38245	COG2226	methyltransferase
JYK04_RS38260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYK04_RS38285	COG2814	Major facilitator Superfamily
JYK04_RS38295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JYK04_RS38305	COG2356	endonuclease I
JYK04_RS38315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JYK04_RS38345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JYK04_RS38355	COG2815	serine threonine protein kinase
JYK04_RS38355	COG0515	serine threonine protein kinase
JYK04_RS38370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JYK04_RS38375	COG0583	DNA-binding transcription factor activity
JYK04_RS38400	COG1024	Enoyl-CoA hydratase
JYK04_RS38410	COG1028	Short-chain dehydrogenase reductase Sdr
JYK04_RS38425	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS38430	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS38445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JYK04_RS38475	COG0515	serine threonine protein kinase
JYK04_RS38475	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JYK04_RS38480	COG4213	ABC transporter substrate-binding protein
JYK04_RS38495	COG2304	oxidoreductase activity
JYK04_RS38515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JYK04_RS38550	COG1301	dicarboxylic acid transport
JYK04_RS38555	COG3290	protein histidine kinase activity
JYK04_RS38560	COG4565	transcriptional regulatory protein
JYK04_RS38580	COG0789	Transcriptional regulator
JYK04_RS38585	COG0076	glutamate decarboxylase activity
JYK04_RS38605	COG1414	Transcriptional regulator
JYK04_RS38610	COG0800	Aldolase
JYK04_RS38655	COG1609	Transcriptional regulator
JYK04_RS38665	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JYK04_RS38685	COG0667	Aldo Keto reductase
JYK04_RS38695	COG1131	(ABC) transporter
JYK04_RS38700	COG1793	dna ligase
JYK04_RS38705	COG0598	Magnesium transport protein CorA
JYK04_RS38745	COG1404	Belongs to the peptidase S8 family
JYK04_RS38745	COG4412	M6 family metalloprotease domain protein
JYK04_RS38745	COG1404	Belongs to the peptidase S8 family
JYK04_RS38745	COG4412	M6 family metalloprotease domain protein
JYK04_RS38760	COG2124	cytochrome p450
JYK04_RS38775	COG3265	gluconokinase activity
JYK04_RS38785	COG1595	DNA-templated transcription, initiation
JYK04_RS38800	COG1021	2,3-dihydroxybenzoate-AMP ligase
JYK04_RS38810	COG1132	(ABC) transporter
JYK04_RS38850	COG2197	response regulator
JYK04_RS38855	COG4585	Histidine kinase
JYK04_RS38975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JYK04_RS38980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JYK04_RS38985	COG2080	2 iron, 2 sulfur cluster binding
JYK04_RS38995	COG4585	Histidine kinase
JYK04_RS39020	COG2124	cytochrome p450
JYK04_RS39030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JYK04_RS39035	COG0596	Alpha beta hydrolase
JYK04_RS39050	COG0277	FAD linked oxidase domain protein
JYK04_RS39065	COG2226	methyltransferase
JYK04_RS39070	COG4264	IucA IucC family
JYK04_RS39075	COG4264	IucA IucC family
JYK04_RS39080	COG0284	orotidine-5'-phosphate decarboxylase activity
JYK04_RS39130	COG1846	Transcriptional regulator
JYK04_RS39135	COG2188	Transcriptional regulator
JYK04_RS39140	COG0517	IMP dehydrogenase activity
JYK04_RS39140	COG4175	Glycine betaine
JYK04_RS39145	COG4176	ABC-type proline glycine betaine transport system permease component
JYK04_RS39150	COG2409	Drug exporters of the RND superfamily
JYK04_RS39160	COG2197	response regulator
JYK04_RS39175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYK04_RS39210	COG0254	rRNA binding
JYK04_RS39280	COG0666	response to abiotic stimulus
JYK04_RS39310	COG0714	Associated with various cellular activities
JYK04_RS39335	COG0596	Alpha beta hydrolase
JYK04_RS39350	COG2272	Belongs to the type-B carboxylesterase lipase family
JYK04_RS39380	COG1796	DNA polymerase
JYK04_RS39380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JYK04_RS39385	COG1846	Transcriptional regulator
JYK04_RS39390	COG1764	response to oxidative stress
JYK04_RS39415	COG1686	Belongs to the peptidase S11 family
JYK04_RS39445	COG0456	acetyltransferase
JYK04_RS39470	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS39500	COG0583	DNA-binding transcription factor activity
JYK04_RS39510	COG2201	protein-glutamate methylesterase activity
JYK04_RS39520	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS39575	COG1595	DNA-templated transcription, initiation
JYK04_RS39585	COG1278	Cold shock
JYK04_RS39590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JYK04_RS39605	COG0328	RNA-DNA hybrid ribonuclease activity
JYK04_RS39635	COG0009	L-threonylcarbamoyladenylate synthase
JYK04_RS39655	COG4106	trans-aconitate 2-methyltransferase activity
JYK04_RS39675	COG1228	amidohydrolase
JYK04_RS39695	COG0596	Alpha beta hydrolase
JYK04_RS39730	COG2205	protein histidine kinase activity
JYK04_RS39735	COG0745	RESPONSE REGULATOR receiver
JYK04_RS39740	COG0477	Major facilitator Superfamily
JYK04_RS39795	COG0596	Alpha beta hydrolase
JYK04_RS39800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JYK04_RS39815	COG0308	aminopeptidase N
JYK04_RS39855	COG3290	protein histidine kinase activity
JYK04_RS39925	COG1316	TRANSCRIPTIONal
JYK04_RS39945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYK04_RS39955	COG1309	transcriptional regulator
JYK04_RS39970	COG1960	acyl-CoA dehydrogenase activity
JYK04_RS39985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JYK04_RS40005	COG1176	ABC-type spermidine putrescine transport system, permease component I
JYK04_RS40010	COG1177	transmembrane transport
JYK04_RS40015	COG3842	ATPase activity
JYK04_RS40025	COG1012	belongs to the aldehyde dehydrogenase family
JYK04_RS40030	COG0667	Aldo Keto reductase
JYK04_RS40035	COG1309	transcriptional regulator
JYK04_RS40075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JYK04_RS40085	COG0644	oxidoreductase
JYK04_RS40095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JYK04_RS40105	COG0318	PFAM AMP-dependent synthetase and ligase
JYK04_RS40140	COG0583	DNA-binding transcription factor activity
JYK04_RS40155	COG1215	transferase activity, transferring glycosyl groups
JYK04_RS40185	COG2197	response regulator
JYK04_RS40255	COG0656	L-ascorbic acid biosynthetic process
JYK04_RS40270	COG0300	oxidoreductase activity
JYK04_RS40295	COG0142	geranyltranstransferase activity
JYK04_RS40305	COG1404	Belongs to the peptidase S8 family
JYK04_RS40370	COG3226	Transcriptional regulator
JYK04_RS40465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JYK04_RS40490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JYK04_RS40500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JYK04_RS40605	COG2175	clavaminate synthase activity
JYK04_RS40715	COG0698	ribose 5-phosphate isomerase