locus-tag	class	description
Spa2297_RS00010	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS00035	COG1846	Transcriptional regulator
Spa2297_RS00100	COG0488	(ABC) transporter
Spa2297_RS00105	COG0488	(ABC) transporter
Spa2297_RS00145	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Spa2297_RS00160	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Spa2297_RS00205	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS00215	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS00245	COG2045	Belongs to the ComB family
Spa2297_RS00255	COG3250	beta-galactosidase activity
Spa2297_RS00265	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spa2297_RS00270	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spa2297_RS00275	COG1129	ABC transporter
Spa2297_RS00280	COG1879	ABC-type sugar transport system periplasmic component
Spa2297_RS00285	COG1609	Transcriptional regulator
Spa2297_RS00305	COG4978	Transcriptional regulator
Spa2297_RS00305	COG0789	Transcriptional regulator
Spa2297_RS00335	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS00340	COG1175	transmembrane transport
Spa2297_RS00360	COG1609	Transcriptional regulator
Spa2297_RS00375	COG1309	transcriptional regulator
Spa2297_RS00445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Spa2297_RS00455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Spa2297_RS00455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Spa2297_RS00465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Spa2297_RS00490	COG2986	histidine ammonia-lyase
Spa2297_RS00500	COG0477	Major facilitator Superfamily
Spa2297_RS00505	COG3104	oligopeptide transport
Spa2297_RS00545	COG1309	transcriptional regulator
Spa2297_RS00580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Spa2297_RS00600	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Spa2297_RS00620	COG3290	protein histidine kinase activity
Spa2297_RS00635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Spa2297_RS00640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS00645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Spa2297_RS00660	COG1595	DNA-templated transcription, initiation
Spa2297_RS00670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Spa2297_RS00685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Spa2297_RS00695	COG3250	beta-galactosidase activity
Spa2297_RS00710	COG3507	Belongs to the glycosyl hydrolase 43 family
Spa2297_RS00715	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS00745	COG3046	protein related to deoxyribodipyrimidine photolyase
Spa2297_RS00750	COG0142	geranyltranstransferase activity
Spa2297_RS00770	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Spa2297_RS00775	COG2226	methyltransferase
Spa2297_RS00850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Spa2297_RS00855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Spa2297_RS00855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Spa2297_RS00860	COG1737	Transcriptional regulator
Spa2297_RS00865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spa2297_RS00870	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Spa2297_RS00875	COG0667	Aldo Keto reductase
Spa2297_RS00880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Spa2297_RS00910	COG1902	pentaerythritol trinitrate reductase activity
Spa2297_RS00925	COG5297	Belongs to the glycosyl hydrolase family 6
Spa2297_RS00925	COG3250	beta-galactosidase activity
Spa2297_RS00965	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS00975	COG0584	glycerophosphoryl diester phosphodiesterase
Spa2297_RS00980	COG0277	FAD linked oxidase domain protein
Spa2297_RS00980	COG0247	lactate metabolic process
Spa2297_RS01010	COG0444	Belongs to the ABC transporter superfamily
Spa2297_RS01015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spa2297_RS01020	COG0601	transmembrane transport
Spa2297_RS01025	COG0747	negative chemotaxis
Spa2297_RS01035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Spa2297_RS01040	COG0494	nUDIX hydrolase
Spa2297_RS01055	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS01085	COG0584	glycerophosphoryl diester phosphodiesterase
Spa2297_RS01095	COG0516	GMP reductase activity
Spa2297_RS01095	COG0517	IMP dehydrogenase activity
Spa2297_RS01110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Spa2297_RS01115	COG2409	Drug exporters of the RND superfamily
Spa2297_RS01140	COG0542	response to heat
Spa2297_RS01145	COG2318	DinB family
Spa2297_RS01160	COG0110	maltose O-acetyltransferase activity
Spa2297_RS01165	COG3226	Transcriptional regulator
Spa2297_RS01170	COG2391	methyltransferase activity
Spa2297_RS01175	COG0326	Molecular chaperone. Has ATPase activity
Spa2297_RS01180	COG2755	lipolytic protein G-D-S-L family
Spa2297_RS01185	COG4977	sequence-specific DNA binding
Spa2297_RS01210	COG2175	clavaminate synthase activity
Spa2297_RS01220	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS01225	COG1175	transmembrane transport
Spa2297_RS01235	COG1609	Transcriptional regulator
Spa2297_RS01240	COG3940	Belongs to the glycosyl hydrolase 43 family
Spa2297_RS01245	COG1953	Uracil, thiamine, allantoin
Spa2297_RS01255	COG1802	Transcriptional regulator
Spa2297_RS01290	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
Spa2297_RS01295	COG1082	Xylose isomerase domain protein TIM barrel
Spa2297_RS01300	COG1063	alcohol dehydrogenase
Spa2297_RS01315	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS01320	COG1940	carbohydrate kinase activity
Spa2297_RS01360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Spa2297_RS01365	COG2151	metal-sulfur cluster biosynthetic enzyme
Spa2297_RS01370	COG3396	Phenylacetate-CoA oxygenase
Spa2297_RS01375	COG3460	Phenylacetate-CoA oxygenase
Spa2297_RS01380	COG3396	Phenylacetate-CoA oxygenase
Spa2297_RS01385	COG2050	protein possibly involved in aromatic compounds catabolism
Spa2297_RS01445	COG1119	ATPase activity
Spa2297_RS01450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Spa2297_RS01455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Spa2297_RS01465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS01485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spa2297_RS01490	COG2188	Transcriptional regulator
Spa2297_RS01500	COG1335	isochorismatase
Spa2297_RS01550	COG0583	DNA-binding transcription factor activity
Spa2297_RS01565	COG2814	Major facilitator Superfamily
Spa2297_RS01575	COG0583	DNA-binding transcription factor activity
Spa2297_RS01580	COG5640	endopeptidase activity
Spa2297_RS01600	COG1017	nitric oxide dioxygenase activity
Spa2297_RS01600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Spa2297_RS01605	COG1959	2 iron, 2 sulfur cluster binding
Spa2297_RS01615	COG2814	Major facilitator Superfamily
Spa2297_RS01685	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Spa2297_RS01690	COG1120	ATPase activity
Spa2297_RS01695	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS01700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS01710	COG1120	ATPase activity
Spa2297_RS01730	COG0477	Major facilitator Superfamily
Spa2297_RS01750	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS01770	COG3537	Alpha-1,2-mannosidase
Spa2297_RS01785	COG0475	glutathione-regulated potassium exporter activity
Spa2297_RS01830	COG0456	acetyltransferase
Spa2297_RS01855	COG0667	Aldo Keto reductase
Spa2297_RS01900	COG0009	L-threonylcarbamoyladenylate synthase
Spa2297_RS01915	COG0656	L-ascorbic acid biosynthetic process
Spa2297_RS01950	COG1793	dna ligase
Spa2297_RS01950	COG3285	dna ligase
Spa2297_RS01960	COG0181	hydroxymethylbilane synthase activity
Spa2297_RS02000	COG0366	Alpha amylase catalytic
Spa2297_RS02015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Spa2297_RS02020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Spa2297_RS02045	COG5002	protein histidine kinase activity
Spa2297_RS02045	COG2205	protein histidine kinase activity
Spa2297_RS02045	COG0784	Response regulator, receiver
Spa2297_RS02060	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS02065	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS02070	COG2172	sigma factor antagonist activity
Spa2297_RS02125	COG1982	Orn Lys Arg decarboxylase major
Spa2297_RS02135	COG0477	Major facilitator Superfamily
Spa2297_RS02145	COG0583	DNA-binding transcription factor activity
Spa2297_RS02155	COG3189	MarR family transcriptional regulator
Spa2297_RS02175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Spa2297_RS02215	COG2340	Cysteine-rich secretory protein family
Spa2297_RS02230	COG2815	serine threonine protein kinase
Spa2297_RS02230	COG0515	serine threonine protein kinase
Spa2297_RS02235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS02255	COG0667	Aldo Keto reductase
Spa2297_RS02265	COG0328	RNA-DNA hybrid ribonuclease activity
Spa2297_RS02280	COG0740	serine-type endopeptidase activity
Spa2297_RS02285	COG0740	serine-type endopeptidase activity
Spa2297_RS02295	COG1191	sigma factor activity
Spa2297_RS02330	COG0667	Aldo Keto reductase
Spa2297_RS02335	COG0583	DNA-binding transcription factor activity
Spa2297_RS02345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Spa2297_RS02350	COG0346	lactoylglutathione lyase activity
Spa2297_RS02370	COG0431	NADPH-dependent FMN reductase
Spa2297_RS02410	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS02455	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS02460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Spa2297_RS02480	COG1473	amidohydrolase
Spa2297_RS02505	COG2205	protein histidine kinase activity
Spa2297_RS02510	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS02555	COG2267	carboxylic ester hydrolase activity
Spa2297_RS02580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Spa2297_RS02585	COG4257	antibiotic catabolic process
Spa2297_RS02590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Spa2297_RS02610	COG2208	phosphoserine phosphatase activity
Spa2297_RS02610	COG2770	Histidine kinase
Spa2297_RS02630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Spa2297_RS02665	COG3483	tryptophan 2,3-dioxygenase activity
Spa2297_RS02685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Spa2297_RS02690	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS02700	COG3251	PFAM MbtH domain protein
Spa2297_RS02720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Spa2297_RS02770	COG0604	alcohol dehydrogenase
Spa2297_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS02820	COG0596	Alpha beta hydrolase
Spa2297_RS02835	COG4106	trans-aconitate 2-methyltransferase activity
Spa2297_RS02860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Spa2297_RS02880	COG2890	protein-(glutamine-N5) methyltransferase activity
Spa2297_RS02885	COG0473	3-isopropylmalate dehydrogenase activity
Spa2297_RS02890	COG0066	3-isopropylmalate dehydratase activity
Spa2297_RS02895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Spa2297_RS02900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Spa2297_RS02935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS02970	COG0436	Aminotransferase
Spa2297_RS02975	COG0434	BtpA family
Spa2297_RS02985	COG3629	intracellular signal transduction
Spa2297_RS03005	COG3629	intracellular signal transduction
Spa2297_RS03005	COG3903	Transcriptional regulator
Spa2297_RS03010	COG2376	Dihydroxyacetone kinase
Spa2297_RS03015	COG1461	Dihydroxyacetone kinase
Spa2297_RS03045	COG1902	pentaerythritol trinitrate reductase activity
Spa2297_RS03045	COG0446	pyridine nucleotide-disulphide oxidoreductase
Spa2297_RS03065	COG2890	protein-(glutamine-N5) methyltransferase activity
Spa2297_RS03075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Spa2297_RS03090	COG3458	cephalosporin-C deacetylase activity
Spa2297_RS03100	COG2226	methyltransferase
Spa2297_RS03115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Spa2297_RS03120	COG1686	Belongs to the peptidase S11 family
Spa2297_RS03130	COG1968	undecaprenyl-diphosphatase activity
Spa2297_RS03135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Spa2297_RS03140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Spa2297_RS03145	COG0640	Transcriptional regulator
Spa2297_RS03150	COG1846	Transcriptional regulator
Spa2297_RS03180	COG0137	argininosuccinate synthase activity
Spa2297_RS03190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Spa2297_RS03200	COG1472	Belongs to the glycosyl hydrolase 3 family
Spa2297_RS03210	COG1175	transmembrane transport
Spa2297_RS03215	COG1653	transport
Spa2297_RS03220	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS03225	COG2205	protein histidine kinase activity
Spa2297_RS03250	COG3246	L-lysine catabolic process to acetate
Spa2297_RS03255	COG1250	3-hydroxyacyl-CoA dehydrogenase
Spa2297_RS03280	COG2409	Drug exporters of the RND superfamily
Spa2297_RS03320	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Spa2297_RS03335	COG0583	DNA-binding transcription factor activity
Spa2297_RS03340	COG3629	intracellular signal transduction
Spa2297_RS03340	COG3903	Transcriptional regulator
Spa2297_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS03380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Spa2297_RS03420	COG1349	DNA-binding transcription factor activity
Spa2297_RS03470	COG1940	carbohydrate kinase activity
Spa2297_RS03480	COG2813	Specifically methylates the guanine in position
Spa2297_RS03490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Spa2297_RS03515	COG0783	Belongs to the Dps family
Spa2297_RS03545	COG2197	response regulator
Spa2297_RS03550	COG4585	Histidine kinase
Spa2297_RS03555	COG0445	tRNA wobble uridine modification
Spa2297_RS03565	COG1660	Displays ATPase and GTPase activities
Spa2297_RS03595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Spa2297_RS03615	COG0204	Acyl-transferase
Spa2297_RS03640	COG0584	glycerophosphoryl diester phosphodiesterase
Spa2297_RS03680	COG0671	phosphoesterase, PA-phosphatase related
Spa2297_RS03705	COG0640	Transcriptional regulator
Spa2297_RS03710	COG1902	pentaerythritol trinitrate reductase activity
Spa2297_RS03720	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS03730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Spa2297_RS03760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Spa2297_RS03790	COG4221	oxidoreductase activity
Spa2297_RS03800	COG0726	polysaccharide deacetylase
Spa2297_RS03810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Spa2297_RS03815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Spa2297_RS03820	COG2080	2 iron, 2 sulfur cluster binding
Spa2297_RS03830	COG4565	transcriptional regulatory protein
Spa2297_RS03835	COG3290	protein histidine kinase activity
Spa2297_RS03865	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Spa2297_RS03870	COG1937	Protein conserved in bacteria
Spa2297_RS03885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Spa2297_RS03885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Spa2297_RS03910	COG0574	Belongs to the PEP-utilizing enzyme family
Spa2297_RS03910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Spa2297_RS03930	COG0516	GMP reductase activity
Spa2297_RS03930	COG0517	IMP dehydrogenase activity
Spa2297_RS03940	COG1063	alcohol dehydrogenase
Spa2297_RS03990	COG0517	IMP dehydrogenase activity
Spa2297_RS04005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Spa2297_RS04010	COG1993	acr, cog1993
Spa2297_RS04015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Spa2297_RS04020	COG0577	efflux transmembrane transporter activity
Spa2297_RS04020	COG1136	(ABC) transporter
Spa2297_RS04030	COG4585	Histidine kinase
Spa2297_RS04035	COG2197	response regulator
Spa2297_RS04040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spa2297_RS04045	COG0798	PFAM Bile acid sodium symporter
Spa2297_RS04050	COG0640	Transcriptional regulator
Spa2297_RS04055	COG2226	methyltransferase
Spa2297_RS04060	COG0432	Pfam Uncharacterised protein family UPF0047
Spa2297_RS04065	COG2072	flavoprotein involved in K transport
Spa2297_RS04080	COG1132	(ABC) transporter
Spa2297_RS04095	COG1132	(ABC) transporter
Spa2297_RS04100	COG1132	(ABC) transporter
Spa2297_RS04110	COG0254	rRNA binding
Spa2297_RS04125	COG1946	Acyl-CoA thioesterase
Spa2297_RS04135	COG2018	Roadblock/LC7 domain
Spa2297_RS04195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Spa2297_RS04205	COG2115	Belongs to the xylose isomerase family
Spa2297_RS04210	COG1070	Carbohydrate kinase
Spa2297_RS04215	COG1846	Transcriptional regulator
Spa2297_RS04215	COG1940	carbohydrate kinase activity
Spa2297_RS04230	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS04235	COG1408	metallophosphoesterase
Spa2297_RS04265	COG0714	Associated with various cellular activities
Spa2297_RS04315	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS04320	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS04330	COG1396	sequence-specific DNA binding
Spa2297_RS04330	COG3800	Transcriptional regulator
Spa2297_RS04340	COG1793	dna ligase
Spa2297_RS04350	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS04360	COG2124	cytochrome p450
Spa2297_RS04365	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS04375	COG0242	peptide deformylase activity
Spa2297_RS04380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Spa2297_RS04385	COG3442	glutamine amidotransferase
Spa2297_RS04390	COG0205	6-phosphofructokinase activity
Spa2297_RS04400	COG3275	phosphorelay sensor kinase activity
Spa2297_RS04405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spa2297_RS04420	COG1522	sequence-specific DNA binding
Spa2297_RS04425	COG1834	amidinotransferase
Spa2297_RS04430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Spa2297_RS04440	COG0477	Major facilitator Superfamily
Spa2297_RS04460	COG0829	nickel cation binding
Spa2297_RS04465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Spa2297_RS04475	COG0804	urea catabolic process
Spa2297_RS04480	COG0832	Belongs to the urease beta subunit family
Spa2297_RS04485	COG0831	urea catabolic process
Spa2297_RS04500	COG0740	serine-type endopeptidase activity
Spa2297_RS04530	COG0156	8-amino-7-oxononanoate synthase activity
Spa2297_RS04535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Spa2297_RS04540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Spa2297_RS04545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Spa2297_RS04550	COG2226	methyltransferase
Spa2297_RS04555	COG0456	acetyltransferase
Spa2297_RS04575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Spa2297_RS04600	COG4585	Histidine kinase
Spa2297_RS04605	COG2197	response regulator
Spa2297_RS04610	COG1940	carbohydrate kinase activity
Spa2297_RS04615	COG2188	Transcriptional regulator
Spa2297_RS04620	COG1595	DNA-templated transcription, initiation
Spa2297_RS04625	COG2267	carboxylic ester hydrolase activity
Spa2297_RS04660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Spa2297_RS04665	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Spa2297_RS04675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Spa2297_RS04675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Spa2297_RS04715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Spa2297_RS04730	COG0626	cystathionine gamma-synthase activity
Spa2297_RS04760	COG1522	sequence-specific DNA binding
Spa2297_RS04765	COG0419	ATPase involved in DNA repair
Spa2297_RS04770	COG0420	3'-5' exonuclease activity
Spa2297_RS04775	COG1739	Uncharacterized protein family UPF0029
Spa2297_RS04790	COG1832	CoA-binding protein
Spa2297_RS04800	COG0640	Transcriptional regulator
Spa2297_RS04825	COG0110	maltose O-acetyltransferase activity
Spa2297_RS04855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Spa2297_RS04865	COG0183	Belongs to the thiolase family
Spa2297_RS04875	COG1968	undecaprenyl-diphosphatase activity
Spa2297_RS04880	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS04885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Spa2297_RS04905	COG2318	DinB family
Spa2297_RS04920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Spa2297_RS04970	COG0697	spore germination
Spa2297_RS05015	COG0384	phenazine biosynthesis protein PhzF
Spa2297_RS05045	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Spa2297_RS05045	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Spa2297_RS05095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Spa2297_RS05125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Spa2297_RS05135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Spa2297_RS05150	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Spa2297_RS05155	COG3447	MASE1 domain protein
Spa2297_RS05155	COG5001	Diguanylate cyclase
Spa2297_RS05155	COG5002	protein histidine kinase activity
Spa2297_RS05160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Spa2297_RS05165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Spa2297_RS05180	COG2018	Roadblock/LC7 domain
Spa2297_RS05195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Spa2297_RS05200	COG2146	nitrite reductase [NAD(P)H] activity
Spa2297_RS05205	COG1414	Transcriptional regulator
Spa2297_RS05250	COG2814	Major facilitator Superfamily
Spa2297_RS05255	COG4336	lyase activity
Spa2297_RS05260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Spa2297_RS05265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Spa2297_RS05270	COG1984	allophanate hydrolase subunit 2
Spa2297_RS05275	COG2755	lipolytic protein G-D-S-L family
Spa2297_RS05280	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS05315	COG2364	Membrane
Spa2297_RS05325	COG2270	Major facilitator Superfamily
Spa2297_RS05335	COG3030	protein affecting phage T7 exclusion by the F plasmid
Spa2297_RS05340	COG1216	Glycosyl transferase, family 2
Spa2297_RS05365	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS05410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Spa2297_RS05415	COG0140	phosphoribosyl-ATP diphosphatase activity
Spa2297_RS05420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Spa2297_RS05425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Spa2297_RS05425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Spa2297_RS05430	COG3201	nicotinamide mononucleotide transporter
Spa2297_RS05445	COG1090	epimerase
Spa2297_RS05460	COG0738	Major facilitator superfamily
Spa2297_RS05465	COG2233	PERMEase
Spa2297_RS05490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Spa2297_RS05505	COG0531	amino acid
Spa2297_RS05520	COG2390	Transcriptional regulator
Spa2297_RS05525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Spa2297_RS05535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Spa2297_RS05550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Spa2297_RS05560	COG1758	RNA polymerase activity
Spa2297_RS05565	COG0194	GDP metabolic process
Spa2297_RS05575	COG0284	orotidine-5'-phosphate decarboxylase activity
Spa2297_RS05580	COG0167	dihydroorotate dehydrogenase activity
Spa2297_RS05585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Spa2297_RS05590	COG0505	Belongs to the CarA family
Spa2297_RS05600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Spa2297_RS05605	COG0540	Belongs to the ATCase OTCase family
Spa2297_RS05610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Spa2297_RS05620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Spa2297_RS05625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Spa2297_RS05630	COG0006	proline dipeptidase activity
Spa2297_RS05640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Spa2297_RS05645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Spa2297_RS05650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Spa2297_RS05655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Spa2297_RS05665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Spa2297_RS05670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Spa2297_RS05690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Spa2297_RS05705	COG0124	histidyl-tRNA synthetase
Spa2297_RS05715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Spa2297_RS05720	COG1196	nuclear chromosome segregation
Spa2297_RS05725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Spa2297_RS05730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Spa2297_RS05735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Spa2297_RS05740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Spa2297_RS05750	COG2255	four-way junction helicase activity
Spa2297_RS05755	COG0632	four-way junction helicase activity
Spa2297_RS05760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Spa2297_RS05765	COG0217	transcriptional regulatory protein
Spa2297_RS05770	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Spa2297_RS05775	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Spa2297_RS05785	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS05790	COG1560	Kdo2-lipid A biosynthetic process
Spa2297_RS05795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Spa2297_RS05815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Spa2297_RS05830	COG2176	DNA-directed DNA polymerase activity
Spa2297_RS05830	COG5002	protein histidine kinase activity
Spa2297_RS05880	COG0456	acetyltransferase
Spa2297_RS05890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Spa2297_RS05940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spa2297_RS05945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Spa2297_RS05945	COG1648	precorrin-2 dehydrogenase activity
Spa2297_RS05950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Spa2297_RS05965	COG1464	Belongs to the NlpA lipoprotein family
Spa2297_RS05970	COG2011	ABC-type metal ion transport system permease component
Spa2297_RS05975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Spa2297_RS05980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Spa2297_RS06005	COG0584	glycerophosphoryl diester phosphodiesterase
Spa2297_RS06010	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS06010	COG0204	Acyl-transferase
Spa2297_RS06015	COG0477	Major facilitator Superfamily
Spa2297_RS06030	COG0165	Argininosuccinate lyase
Spa2297_RS06065	COG1438	arginine binding
Spa2297_RS06070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Spa2297_RS06075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Spa2297_RS06080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Spa2297_RS06085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Spa2297_RS06105	COG0697	spore germination
Spa2297_RS06115	COG1649	PFAM Uncharacterised BCR, COG1649
Spa2297_RS06140	COG0072	phenylalanine-tRNA ligase activity
Spa2297_RS06140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spa2297_RS06145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Spa2297_RS06150	COG5002	protein histidine kinase activity
Spa2297_RS06155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spa2297_RS06160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Spa2297_RS06165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Spa2297_RS06170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Spa2297_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS06215	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS06220	COG0174	glutamine synthetase
Spa2297_RS06225	COG2186	Transcriptional regulator
Spa2297_RS06230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Spa2297_RS06255	COG4176	ABC-type proline glycine betaine transport system permease component
Spa2297_RS06260	COG4175	Glycine betaine
Spa2297_RS06260	COG0517	IMP dehydrogenase activity
Spa2297_RS06265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Spa2297_RS06280	COG0564	pseudouridine synthase activity
Spa2297_RS06315	COG0805	protein transport
Spa2297_RS06320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Spa2297_RS06340	COG2378	regulation of single-species biofilm formation
Spa2297_RS06350	COG0545	Peptidyl-prolyl cis-trans isomerase
Spa2297_RS06355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Spa2297_RS06365	COG1609	Transcriptional regulator
Spa2297_RS06370	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Spa2297_RS06375	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Spa2297_RS06385	COG4122	O-methyltransferase activity
Spa2297_RS06390	COG1222	aaa ATPase
Spa2297_RS06410	COG1994	Peptidase M50
Spa2297_RS06410	COG0517	IMP dehydrogenase activity
Spa2297_RS06420	COG2197	response regulator
Spa2297_RS06425	COG4166	transmembrane transport
Spa2297_RS06430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Spa2297_RS06435	COG1410	methionine synthase
Spa2297_RS06435	COG0646	methionine synthase
Spa2297_RS06440	COG1414	Transcriptional regulator
Spa2297_RS06445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Spa2297_RS06450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Spa2297_RS06455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Spa2297_RS06465	COG0215	cysteine-tRNA ligase activity
Spa2297_RS06480	COG0588	phosphoglycerate mutase activity
Spa2297_RS06485	COG0598	Magnesium transport protein CorA
Spa2297_RS06495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS06500	COG0667	Aldo Keto reductase
Spa2297_RS06530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spa2297_RS06540	COG3012	SEC-C Motif Domain Protein
Spa2297_RS06545	COG2186	Transcriptional regulator
Spa2297_RS06550	COG3265	gluconokinase activity
Spa2297_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS06565	COG1063	alcohol dehydrogenase
Spa2297_RS06585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Spa2297_RS06590	COG2149	membrane
Spa2297_RS06615	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS06625	COG3876	Protein conserved in bacteria
Spa2297_RS06645	COG0789	Transcriptional regulator
Spa2297_RS06665	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS06675	COG0640	Transcriptional regulator
Spa2297_RS06700	COG3842	ATPase activity
Spa2297_RS06715	COG2851	Citrate transporter
Spa2297_RS06720	COG0243	molybdopterin cofactor binding
Spa2297_RS06725	COG1309	transcriptional regulator
Spa2297_RS06735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Spa2297_RS06740	COG2188	Transcriptional regulator
Spa2297_RS06760	COG1595	DNA-templated transcription, initiation
Spa2297_RS06765	COG2815	serine threonine protein kinase
Spa2297_RS06765	COG0515	serine threonine protein kinase
Spa2297_RS06770	COG2755	lipolytic protein G-D-S-L family
Spa2297_RS06800	COG1725	Transcriptional regulator
Spa2297_RS06840	COG0587	DNA-directed DNA polymerase activity
Spa2297_RS06865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS06880	COG1799	cell septum assembly
Spa2297_RS06885	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS06890	COG0477	Major facilitator Superfamily
Spa2297_RS06900	COG0671	phosphoesterase, PA-phosphatase related
Spa2297_RS06925	COG1160	GTP binding
Spa2297_RS06935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Spa2297_RS06965	COG1187	pseudouridine synthase activity
Spa2297_RS06970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Spa2297_RS06975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Spa2297_RS06990	COG0686	Belongs to the AlaDH PNT family
Spa2297_RS07000	COG0494	nUDIX hydrolase
Spa2297_RS07005	COG0504	CTP synthase activity
Spa2297_RS07010	COG3387	PFAM Glycoside hydrolase 15-related
Spa2297_RS07030	COG0497	DNA recombination
Spa2297_RS07035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Spa2297_RS07055	COG1120	ATPase activity
Spa2297_RS07060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS07065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS07070	COG0647	UMP catabolic process
Spa2297_RS07105	COG2094	Belongs to the DNA glycosylase MPG family
Spa2297_RS07115	COG1881	PFAM PEBP family protein
Spa2297_RS07135	COG1119	ATPase activity
Spa2297_RS07150	COG2197	response regulator
Spa2297_RS07155	COG4585	Histidine kinase
Spa2297_RS07160	COG4221	oxidoreductase activity
Spa2297_RS07175	COG0842	Transport permease protein
Spa2297_RS07175	COG1716	ATPase activity
Spa2297_RS07175	COG1131	(ABC) transporter
Spa2297_RS07185	COG3830	Belongs to the UPF0237 family
Spa2297_RS07185	COG0560	Phosphoserine phosphatase
Spa2297_RS07190	COG0588	phosphoglycerate mutase activity
Spa2297_RS07205	COG2186	Transcriptional regulator
Spa2297_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS07235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Spa2297_RS07255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Spa2297_RS07260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spa2297_RS07275	COG1404	Belongs to the peptidase S8 family
Spa2297_RS07285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Spa2297_RS07300	COG3387	PFAM Glycoside hydrolase 15-related
Spa2297_RS07340	COG1024	Enoyl-CoA hydratase
Spa2297_RS07350	COG0488	(ABC) transporter
Spa2297_RS07365	COG0235	Class ii aldolase
Spa2297_RS07380	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Spa2297_RS07385	COG1492	cobalamin metabolic process
Spa2297_RS07400	COG1797	cobyrinic acid a,c-diamide synthase activity
Spa2297_RS07430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Spa2297_RS07435	COG0456	acetyltransferase
Spa2297_RS07440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Spa2297_RS07445	COG1917	Cupin 2, conserved barrel domain protein
Spa2297_RS07450	COG5285	phytanoyl-CoA dioxygenase
Spa2297_RS07480	COG1414	Transcriptional regulator
Spa2297_RS07500	COG3866	Pectate lyase
Spa2297_RS07525	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS07530	COG1175	transmembrane transport
Spa2297_RS07545	COG1802	Transcriptional regulator
Spa2297_RS07560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spa2297_RS07565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Spa2297_RS07570	COG1349	DNA-binding transcription factor activity
Spa2297_RS07590	COG1063	alcohol dehydrogenase
Spa2297_RS07635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spa2297_RS07710	COG2171	N-acyltransferase activity
Spa2297_RS07715	COG3226	Transcriptional regulator
Spa2297_RS07720	COG2076	Multidrug Resistance protein
Spa2297_RS07725	COG2151	metal-sulfur cluster biosynthetic enzyme
Spa2297_RS07730	COG0822	iron-sulfur transferase activity
Spa2297_RS07735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Spa2297_RS07740	COG0396	ATPase activity
Spa2297_RS07750	COG0719	Fe-S assembly protein
Spa2297_RS07765	COG2746	aminoglycoside 3-N-acetyltransferase activity
Spa2297_RS07780	COG1612	heme a metabolic process
Spa2297_RS07795	COG0109	protoheme IX farnesyltransferase activity
Spa2297_RS07805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Spa2297_RS07820	COG0363	glucosamine-6-phosphate deaminase activity
Spa2297_RS07825	COG0166	Belongs to the GPI family
Spa2297_RS07835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Spa2297_RS07840	COG0149	triose-phosphate isomerase activity
Spa2297_RS07845	COG0126	phosphoglycerate kinase activity
Spa2297_RS07850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Spa2297_RS07860	COG1481	regulation of sporulation
Spa2297_RS07865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Spa2297_RS07870	COG1660	Displays ATPase and GTPase activities
Spa2297_RS07875	COG0322	excinuclease ABC activity
Spa2297_RS07895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spa2297_RS07900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Spa2297_RS07915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Spa2297_RS07920	COG0387	Pfam Sodium calcium exchanger
Spa2297_RS07940	COG0556	nucleotide-excision repair
Spa2297_RS07950	COG0584	glycerophosphoryl diester phosphodiesterase
Spa2297_RS07955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Spa2297_RS07965	COG2313	pseudouridylate synthase activity
Spa2297_RS07970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Spa2297_RS07970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Spa2297_RS07975	COG2226	methyltransferase
Spa2297_RS07980	COG0598	Magnesium transport protein CorA
Spa2297_RS08035	COG0402	S-adenosylhomocysteine deaminase activity
Spa2297_RS08060	COG2267	carboxylic ester hydrolase activity
Spa2297_RS08080	COG2226	methyltransferase
Spa2297_RS08095	COG0237	dephospho-CoA kinase activity
Spa2297_RS08110	COG2226	methyltransferase
Spa2297_RS08115	COG1643	Atp-dependent helicase
Spa2297_RS08145	COG2050	protein possibly involved in aromatic compounds catabolism
Spa2297_RS08200	COG0737	Belongs to the 5'-nucleotidase family
Spa2297_RS08215	COG0287	Prephenate dehydrogenase
Spa2297_RS08215	COG1605	Chorismate mutase
Spa2297_RS08230	COG2304	oxidoreductase activity
Spa2297_RS08245	COG0070	glutamate synthase
Spa2297_RS08245	COG0067	glutamate synthase
Spa2297_RS08245	COG0069	glutamate synthase activity
Spa2297_RS08275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Spa2297_RS08280	COG2301	Belongs to the HpcH HpaI aldolase family
Spa2297_RS08285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Spa2297_RS08295	COG0159	tryptophan synthase activity
Spa2297_RS08300	COG0133	tryptophan synthase activity
Spa2297_RS08305	COG0134	indole-3-glycerol-phosphate synthase activity
Spa2297_RS08330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Spa2297_RS08350	COG0107	imidazoleglycerol-phosphate synthase activity
Spa2297_RS08355	COG0251	oxidation-reduction process
Spa2297_RS08360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Spa2297_RS08365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Spa2297_RS08370	COG0131	Imidazoleglycerol-phosphate dehydratase
Spa2297_RS08375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Spa2297_RS08380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Spa2297_RS08400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Spa2297_RS08420	COG1432	Conserved Protein
Spa2297_RS08425	COG0587	DNA-directed DNA polymerase activity
Spa2297_RS08475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Spa2297_RS08485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Spa2297_RS08490	COG3599	regulation of cell shape
Spa2297_RS08500	COG1799	cell septum assembly
Spa2297_RS08510	COG1496	oxidoreductase activity
Spa2297_RS08515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Spa2297_RS08520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Spa2297_RS08525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Spa2297_RS08535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Spa2297_RS08540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Spa2297_RS08550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Spa2297_RS08555	COG0768	penicillin binding
Spa2297_RS08565	COG0275	rRNA processing
Spa2297_RS08575	COG0714	Associated with various cellular activities
Spa2297_RS08595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Spa2297_RS08605	COG1309	transcriptional regulator
Spa2297_RS08625	COG0352	thiamine-phosphate diphosphorylase activity
Spa2297_RS08645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Spa2297_RS08645	COG2022	thiamine diphosphate biosynthetic process
Spa2297_RS08655	COG2022	thiamine diphosphate biosynthetic process
Spa2297_RS08660	COG0515	serine threonine protein kinase
Spa2297_RS08660	COG2815	serine threonine protein kinase
Spa2297_RS08665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Spa2297_RS08670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Spa2297_RS08675	COG2193	ferroxidase activity
Spa2297_RS08685	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Spa2297_RS08700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Spa2297_RS08705	COG0205	6-phosphofructokinase activity
Spa2297_RS08710	COG2197	response regulator
Spa2297_RS08740	COG1940	carbohydrate kinase activity
Spa2297_RS08750	COG0003	Pfam Anion-transporting ATPase
Spa2297_RS08770	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS08820	COG2205	protein histidine kinase activity
Spa2297_RS08825	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS08835	COG1929	Belongs to the glycerate kinase type-1 family
Spa2297_RS08840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Spa2297_RS08845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Spa2297_RS08850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Spa2297_RS08855	COG0723	plastoquinol--plastocyanin reductase activity
Spa2297_RS08860	COG2010	Cytochrome c
Spa2297_RS08865	COG1845	cytochrome c oxidase, subunit III
Spa2297_RS08875	COG1376	ErfK ybiS ycfS ynhG family protein
Spa2297_RS08885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Spa2297_RS08890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Spa2297_RS08895	COG1104	cysteine desulfurase activity
Spa2297_RS08900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spa2297_RS08920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Spa2297_RS08930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Spa2297_RS08935	COG2197	response regulator
Spa2297_RS08940	COG4585	Histidine kinase
Spa2297_RS08965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spa2297_RS08985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Spa2297_RS08995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Spa2297_RS09005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Spa2297_RS09010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Spa2297_RS09015	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spa2297_RS09025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Spa2297_RS09070	COG0321	lipoyl(octanoyl) transferase activity
Spa2297_RS09075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Spa2297_RS09095	COG0174	glutamine synthetase
Spa2297_RS09100	COG4974	Belongs to the 'phage' integrase family
Spa2297_RS09235	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS09250	COG2197	response regulator
Spa2297_RS09285	COG1309	transcriptional regulator
Spa2297_RS09310	COG0366	Alpha amylase catalytic
Spa2297_RS09315	COG3833	ABC-type maltose transport systems, permease component
Spa2297_RS09320	COG1175	transmembrane transport
Spa2297_RS09325	COG2182	Extracellular solute-binding protein
Spa2297_RS09330	COG1609	Transcriptional regulator
Spa2297_RS09340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Spa2297_RS09350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Spa2297_RS09350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Spa2297_RS09365	COG0174	glutamine synthetase
Spa2297_RS09375	COG0596	Alpha beta hydrolase
Spa2297_RS09400	COG2814	Major facilitator Superfamily
Spa2297_RS09410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Spa2297_RS09430	COG1994	Peptidase M50
Spa2297_RS09490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Spa2297_RS09495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS09500	COG1120	ATPase activity
Spa2297_RS09525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Spa2297_RS09530	COG2814	Major facilitator Superfamily
Spa2297_RS09540	COG3540	Alkaline phosphatase
Spa2297_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS09605	COG3022	response to hydroperoxide
Spa2297_RS09610	COG0800	Aldolase
Spa2297_RS09625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Spa2297_RS09635	COG2030	dehydratase
Spa2297_RS09640	COG4585	Histidine kinase
Spa2297_RS09650	COG2197	response regulator
Spa2297_RS09660	COG0477	Major facilitator Superfamily
Spa2297_RS09670	COG0860	N-Acetylmuramoyl-L-alanine amidase
Spa2297_RS09670	COG2247	cell wall binding repeat
Spa2297_RS09695	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS09700	COG1309	transcriptional regulator
Spa2297_RS09720	COG3845	ABC transporter
Spa2297_RS09735	COG1335	isochorismatase
Spa2297_RS09795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Spa2297_RS09920	COG0586	Pfam SNARE associated Golgi protein
Spa2297_RS09930	COG1358	cellular component organization or biogenesis
Spa2297_RS09975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Spa2297_RS09985	COG0477	Major facilitator Superfamily
Spa2297_RS09990	COG1309	transcriptional regulator
Spa2297_RS10005	COG0667	Aldo Keto reductase
Spa2297_RS10010	COG0789	Transcriptional regulator
Spa2297_RS10025	COG1741	Belongs to the pirin family
Spa2297_RS10040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Spa2297_RS10045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spa2297_RS10050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spa2297_RS10085	COG1764	response to oxidative stress
Spa2297_RS10090	COG2130	NADP-dependent
Spa2297_RS10125	COG1129	ABC transporter
Spa2297_RS10130	COG4214	carbohydrate transport
Spa2297_RS10140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Spa2297_RS10200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Spa2297_RS10210	COG1127	ABC transporter
Spa2297_RS10235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Spa2297_RS10290	COG1414	Transcriptional regulator
Spa2297_RS10310	COG2186	Transcriptional regulator
Spa2297_RS10320	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS10325	COG0825	malonyl-CoA metabolic process
Spa2297_RS10325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Spa2297_RS10335	COG1077	Cell shape determining protein MreB Mrl
Spa2297_RS10385	COG1070	Carbohydrate kinase
Spa2297_RS10410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spa2297_RS10415	COG0358	DNA primase activity
Spa2297_RS10425	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Spa2297_RS10435	COG2949	membrane
Spa2297_RS10440	COG0243	molybdopterin cofactor binding
Spa2297_RS10485	COG2146	nitrite reductase [NAD(P)H] activity
Spa2297_RS10485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Spa2297_RS10495	COG1309	transcriptional regulator
Spa2297_RS10500	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS10520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Spa2297_RS10525	COG0574	Belongs to the PEP-utilizing enzyme family
Spa2297_RS10525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Spa2297_RS10545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Spa2297_RS10560	COG0423	glycine-tRNA ligase activity
Spa2297_RS10565	COG0803	Belongs to the bacterial solute-binding protein 9 family
Spa2297_RS10565	COG3443	Belongs to the bacterial solute-binding protein 9 family
Spa2297_RS10570	COG1121	(ABC) transporter
Spa2297_RS10575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Spa2297_RS10585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Spa2297_RS10590	COG1381	Involved in DNA repair and RecF pathway recombination
Spa2297_RS10600	COG0596	Alpha beta hydrolase
Spa2297_RS10645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Spa2297_RS10670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Spa2297_RS10680	COG2315	Protein conserved in bacteria
Spa2297_RS10700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Spa2297_RS10705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spa2297_RS10710	COG4948	Mandelate Racemase Muconate Lactonizing
Spa2297_RS10720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Spa2297_RS10725	COG1234	tRNA 3'-trailer cleavage
Spa2297_RS10730	COG0537	adenosine 5'-monophosphoramidase activity
Spa2297_RS10735	COG0793	Belongs to the peptidase S41A family
Spa2297_RS10735	COG4946	Tricorn protease homolog
Spa2297_RS10755	COG0484	heat shock protein binding
Spa2297_RS10760	COG1420	regulation of RNA biosynthetic process
Spa2297_RS10790	COG0481	GTPase activity
Spa2297_RS10795	COG0268	Binds directly to 16S ribosomal RNA
Spa2297_RS10815	COG2353	YceI-like domain
Spa2297_RS10825	COG1234	tRNA 3'-trailer cleavage
Spa2297_RS10830	COG1555	photosystem II stabilization
Spa2297_RS10835	COG1307	EDD domain protein, DegV family
Spa2297_RS10845	COG0495	leucyl-tRNA aminoacylation
Spa2297_RS10855	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Spa2297_RS10875	COG0588	phosphoglycerate mutase activity
Spa2297_RS10880	COG0799	negative regulation of ribosome biogenesis
Spa2297_RS10890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Spa2297_RS10900	COG0501	Belongs to the peptidase M48B family
Spa2297_RS10915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Spa2297_RS10925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Spa2297_RS10940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Spa2297_RS10945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Spa2297_RS10950	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS10955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Spa2297_RS10960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Spa2297_RS10965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Spa2297_RS10970	COG1530	ribonuclease E activity
Spa2297_RS11015	COG0772	Belongs to the SEDS family
Spa2297_RS11020	COG0768	penicillin binding
Spa2297_RS11035	COG1077	Cell shape determining protein MreB Mrl
Spa2297_RS11040	COG0105	UTP biosynthetic process
Spa2297_RS11050	COG0285	dihydrofolate synthase activity
Spa2297_RS11055	COG0525	valine-tRNA ligase activity
Spa2297_RS11065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Spa2297_RS11070	COG0740	serine-type endopeptidase activity
Spa2297_RS11075	COG0740	serine-type endopeptidase activity
Spa2297_RS11080	COG0544	peptidyl-prolyl cis-trans isomerase activity
Spa2297_RS11100	COG3594	Acyltransferase
Spa2297_RS11105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Spa2297_RS11115	COG4552	Acetyltransferase involved in intracellular survival and related
Spa2297_RS11130	COG1113	amino acid transport
Spa2297_RS11135	COG1268	BioY protein
Spa2297_RS11140	COG1113	amino acid transport
Spa2297_RS11145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Spa2297_RS11155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Spa2297_RS11210	COG0697	spore germination
Spa2297_RS11215	COG1846	Transcriptional regulator
Spa2297_RS11245	COG0668	transmembrane transport
Spa2297_RS11260	COG1175	transmembrane transport
Spa2297_RS11265	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS11270	COG1486	melibiose metabolic process
Spa2297_RS11285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Spa2297_RS11300	COG0515	serine threonine protein kinase
Spa2297_RS11320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Spa2297_RS11325	COG2346	COG2346, Truncated hemoglobins
Spa2297_RS11340	COG1136	(ABC) transporter
Spa2297_RS11370	COG0488	(ABC) transporter
Spa2297_RS11380	COG0629	single-stranded DNA binding
Spa2297_RS11400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Spa2297_RS11415	COG2304	oxidoreductase activity
Spa2297_RS11445	COG0297	glycogen (starch) synthase activity
Spa2297_RS11450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Spa2297_RS11470	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS11530	COG1131	(ABC) transporter
Spa2297_RS11570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Spa2297_RS11580	COG0640	Transcriptional regulator
Spa2297_RS11585	COG1595	DNA-templated transcription, initiation
Spa2297_RS11600	COG1609	Transcriptional regulator
Spa2297_RS11605	COG1129	ABC transporter
Spa2297_RS11610	COG1879	ABC-type sugar transport system periplasmic component
Spa2297_RS11615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spa2297_RS11620	COG1869	D-ribose catabolic process
Spa2297_RS11635	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS11670	COG1472	Belongs to the glycosyl hydrolase 3 family
Spa2297_RS11695	COG2356	endonuclease I
Spa2297_RS11710	COG0028	Belongs to the TPP enzyme family
Spa2297_RS11720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spa2297_RS11740	COG1946	Acyl-CoA thioesterase
Spa2297_RS11750	COG1309	transcriptional regulator
Spa2297_RS11755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Spa2297_RS11770	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS11790	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Spa2297_RS11820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Spa2297_RS11825	COG0589	response to stress
Spa2297_RS11835	COG4977	sequence-specific DNA binding
Spa2297_RS11840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Spa2297_RS11875	COG3469	chitinase activity
Spa2297_RS11885	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS11895	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Spa2297_RS11935	COG1846	Transcriptional regulator
Spa2297_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS11975	COG2267	carboxylic ester hydrolase activity
Spa2297_RS11980	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Spa2297_RS11995	COG0477	Major facilitator Superfamily
Spa2297_RS12015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS12060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Spa2297_RS12075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Spa2297_RS12080	COG0765	amino acid transport
Spa2297_RS12085	COG0765	amino acid transport
Spa2297_RS12090	COG1126	abc transporter atp-binding protein
Spa2297_RS12105	COG3397	chitin binding
Spa2297_RS12185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Spa2297_RS12190	COG2188	Transcriptional regulator
Spa2297_RS12205	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS12210	COG4702	Belongs to the UPF0303 family
Spa2297_RS12225	COG0706	membrane insertase activity
Spa2297_RS12250	COG4221	oxidoreductase activity
Spa2297_RS12270	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Spa2297_RS12285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Spa2297_RS12325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Spa2297_RS12350	COG2733	membrane
Spa2297_RS12365	COG4555	ABC transporter
Spa2297_RS12380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Spa2297_RS12410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Spa2297_RS12420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Spa2297_RS12425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Spa2297_RS12430	COG1263	PTS System
Spa2297_RS12435	COG1263	PTS System
Spa2297_RS12440	COG1234	tRNA 3'-trailer cleavage
Spa2297_RS12465	COG1113	amino acid transport
Spa2297_RS12475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Spa2297_RS12485	COG1335	isochorismatase
Spa2297_RS12505	COG1714	RDD family
Spa2297_RS12520	COG0277	FAD linked oxidase domain protein
Spa2297_RS12530	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Spa2297_RS12540	COG1174	glycine betaine transport
Spa2297_RS12550	COG1174	glycine betaine transport
Spa2297_RS12560	COG3480	Lon protease (S16) C-terminal proteolytic domain
Spa2297_RS12680	COG2188	Transcriptional regulator
Spa2297_RS12685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Spa2297_RS12695	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Spa2297_RS12710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Spa2297_RS12715	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS12735	COG1678	Uncharacterized ACR, COG1678
Spa2297_RS12740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Spa2297_RS12745	COG0776	regulation of translation
Spa2297_RS12755	COG3973	AAA domain
Spa2297_RS12780	COG2223	nitrite transmembrane transporter activity
Spa2297_RS12805	COG0583	DNA-binding transcription factor activity
Spa2297_RS12820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Spa2297_RS12825	COG0793	Belongs to the peptidase S41A family
Spa2297_RS12835	COG2884	Cell division ATP-binding protein ftsE
Spa2297_RS12850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Spa2297_RS12855	COG0515	serine threonine protein kinase
Spa2297_RS12860	COG0515	serine threonine protein kinase
Spa2297_RS12875	COG1175	transmembrane transport
Spa2297_RS12880	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS12885	COG1216	Glycosyl transferase, family 2
Spa2297_RS12890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Spa2297_RS12910	COG1764	response to oxidative stress
Spa2297_RS12915	COG1846	Transcriptional regulator
Spa2297_RS12935	COG1134	teichoic acid transport
Spa2297_RS12940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Spa2297_RS12945	COG1216	Glycosyl transferase, family 2
Spa2297_RS12955	COG2902	Dehydrogenase
Spa2297_RS12975	COG0653	protein targeting
Spa2297_RS12985	COG3214	Protein conserved in bacteria
Spa2297_RS12990	COG2197	response regulator
Spa2297_RS12995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Spa2297_RS13005	COG0823	Involved in the tonB-independent uptake of proteins
Spa2297_RS13010	COG5002	protein histidine kinase activity
Spa2297_RS13015	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS13020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Spa2297_RS13040	COG0714	Associated with various cellular activities
Spa2297_RS13085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Spa2297_RS13095	COG1482	cell wall glycoprotein biosynthetic process
Spa2297_RS13105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Spa2297_RS13110	COG1620	l-lactate permease
Spa2297_RS13145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Spa2297_RS13150	COG0778	Nitroreductase
Spa2297_RS13150	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Spa2297_RS13175	COG1316	TRANSCRIPTIONal
Spa2297_RS13180	COG1316	TRANSCRIPTIONal
Spa2297_RS13185	COG1316	TRANSCRIPTIONal
Spa2297_RS13190	COG1316	TRANSCRIPTIONal
Spa2297_RS13195	COG1316	TRANSCRIPTIONal
Spa2297_RS13205	COG1316	TRANSCRIPTIONal
Spa2297_RS13210	COG1316	TRANSCRIPTIONal
Spa2297_RS13225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Spa2297_RS13255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Spa2297_RS13270	COG2205	protein histidine kinase activity
Spa2297_RS13275	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS13280	COG3104	oligopeptide transport
Spa2297_RS13285	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS13305	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS13310	COG1191	sigma factor activity
Spa2297_RS13315	COG1228	amidohydrolase
Spa2297_RS13325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spa2297_RS13330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Spa2297_RS13335	COG0019	diaminopimelate decarboxylase activity
Spa2297_RS13365	COG2755	lipolytic protein G-D-S-L family
Spa2297_RS13370	COG0183	Belongs to the thiolase family
Spa2297_RS13410	COG1136	(ABC) transporter
Spa2297_RS13415	COG0577	efflux transmembrane transporter activity
Spa2297_RS13415	COG1136	(ABC) transporter
Spa2297_RS13420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Spa2297_RS13425	COG1252	NADH dehydrogenase
Spa2297_RS13445	COG0148	phosphopyruvate hydratase activity
Spa2297_RS13455	COG1652	LysM domain
Spa2297_RS13500	COG0577	efflux transmembrane transporter activity
Spa2297_RS13505	COG1136	(ABC) transporter
Spa2297_RS13515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spa2297_RS13545	COG4585	Histidine kinase
Spa2297_RS13550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Spa2297_RS13555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Spa2297_RS13560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Spa2297_RS13565	COG0193	aminoacyl-tRNA hydrolase activity
Spa2297_RS13575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Spa2297_RS13585	COG1309	transcriptional regulator
Spa2297_RS13590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Spa2297_RS13595	COG4106	trans-aconitate 2-methyltransferase activity
Spa2297_RS13605	COG2197	response regulator
Spa2297_RS13645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Spa2297_RS13685	COG0488	(ABC) transporter
Spa2297_RS13690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Spa2297_RS13695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Spa2297_RS13705	COG0084	hydrolase, TatD family'
Spa2297_RS13740	COG0310	cobalt ion transport
Spa2297_RS13750	COG1122	ATPase activity
Spa2297_RS13755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Spa2297_RS13770	COG0442	prolyl-tRNA aminoacylation
Spa2297_RS13775	COG2409	Drug exporters of the RND superfamily
Spa2297_RS13785	COG4946	Tricorn protease homolog
Spa2297_RS13785	COG0793	Belongs to the peptidase S41A family
Spa2297_RS13800	COG2267	carboxylic ester hydrolase activity
Spa2297_RS13805	COG2072	flavoprotein involved in K transport
Spa2297_RS13835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Spa2297_RS13840	COG0521	Mo-molybdopterin cofactor biosynthetic process
Spa2297_RS13840	COG0315	cyclic pyranopterin monophosphate synthase activity
Spa2297_RS13845	COG0315	cyclic pyranopterin monophosphate synthase activity
Spa2297_RS13855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Spa2297_RS13860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Spa2297_RS13880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Spa2297_RS13890	COG1970	mechanosensitive ion channel activity
Spa2297_RS13910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Spa2297_RS13910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spa2297_RS13910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Spa2297_RS13920	COG1349	DNA-binding transcription factor activity
Spa2297_RS13925	COG0477	Major facilitator Superfamily
Spa2297_RS13940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spa2297_RS13945	COG1247	-acetyltransferase
Spa2297_RS13950	COG3384	dioxygenase
Spa2297_RS13955	COG1846	Transcriptional regulator
Spa2297_RS13975	COG1414	Transcriptional regulator
Spa2297_RS14020	COG0443	Heat shock 70 kDa protein
Spa2297_RS14025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Spa2297_RS14040	COG0542	response to heat
Spa2297_RS14080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spa2297_RS14085	COG0798	PFAM Bile acid sodium symporter
Spa2297_RS14090	COG0640	Transcriptional regulator
Spa2297_RS14100	COG0586	Pfam SNARE associated Golgi protein
Spa2297_RS14105	COG4585	Histidine kinase
Spa2297_RS14110	COG2197	response regulator
Spa2297_RS14120	COG3655	Transcriptional regulator
Spa2297_RS14150	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Spa2297_RS14155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Spa2297_RS14160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Spa2297_RS14190	COG3795	YCII-related domain
Spa2297_RS14195	COG4941	Belongs to the sigma-70 factor family
Spa2297_RS14200	COG0477	Major facilitator Superfamily
Spa2297_RS14215	COG0386	Belongs to the glutathione peroxidase family
Spa2297_RS14235	COG1686	Belongs to the peptidase S11 family
Spa2297_RS14305	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Spa2297_RS14325	COG3903	Transcriptional regulator
Spa2297_RS14325	COG3629	intracellular signal transduction
Spa2297_RS14340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Spa2297_RS14340	COG0515	serine threonine protein kinase
Spa2297_RS14350	COG1309	transcriptional regulator
Spa2297_RS14360	COG0259	pyridoxamine-phosphate oxidase activity
Spa2297_RS14370	COG2072	flavoprotein involved in K transport
Spa2297_RS14375	COG2271	Major facilitator Superfamily
Spa2297_RS14395	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS14400	COG1595	DNA-templated transcription, initiation
Spa2297_RS14450	COG0596	Alpha beta hydrolase
Spa2297_RS14450	COG2945	thiolester hydrolase activity
Spa2297_RS14460	COG4821	SIS domain
Spa2297_RS14475	COG0259	pyridoxamine-phosphate oxidase activity
Spa2297_RS14490	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS14505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Spa2297_RS14520	COG0515	serine threonine protein kinase
Spa2297_RS14520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Spa2297_RS14540	COG2318	DinB family
Spa2297_RS14550	COG0277	FAD linked oxidase domain protein
Spa2297_RS14550	COG0247	lactate metabolic process
Spa2297_RS14555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Spa2297_RS14560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Spa2297_RS14590	COG0667	Aldo Keto reductase
Spa2297_RS14620	COG2252	PERMEase
Spa2297_RS14630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Spa2297_RS14645	COG2814	Major facilitator Superfamily
Spa2297_RS14655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Spa2297_RS14660	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Spa2297_RS14665	COG1278	Cold shock
Spa2297_RS14695	COG1061	Type III restriction enzyme res subunit
Spa2297_RS14705	COG3973	AAA domain
Spa2297_RS14745	COG1737	Transcriptional regulator
Spa2297_RS14750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Spa2297_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS14770	COG1309	transcriptional regulator
Spa2297_RS14805	COG0459	protein refolding
Spa2297_RS14810	COG1278	Cold shock
Spa2297_RS14825	COG0463	Glycosyl transferase, family 2
Spa2297_RS14850	COG1940	carbohydrate kinase activity
Spa2297_RS14855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Spa2297_RS14870	COG5001	Diguanylate cyclase
Spa2297_RS14870	COG3300	MHYT domain
Spa2297_RS14895	COG2197	response regulator
Spa2297_RS14960	COG0464	growth
Spa2297_RS15050	COG3842	ATPase activity
Spa2297_RS15070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spa2297_RS15075	COG0215	cysteine-tRNA ligase activity
Spa2297_RS15080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Spa2297_RS15085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Spa2297_RS15090	COG1329	Transcriptional regulator
Spa2297_RS15105	COG5002	protein histidine kinase activity
Spa2297_RS15125	COG3708	Transcriptional regulator
Spa2297_RS15125	COG2207	Transcriptional regulator
Spa2297_RS15145	COG0588	phosphoglycerate mutase activity
Spa2297_RS15170	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS15230	COG0546	phosphoglycolate phosphatase activity
Spa2297_RS15235	COG2188	Transcriptional regulator
Spa2297_RS15245	COG2188	Transcriptional regulator
Spa2297_RS15255	COG4552	Acetyltransferase involved in intracellular survival and related
Spa2297_RS15270	COG1490	D-aminoacyl-tRNA deacylase activity
Spa2297_RS15275	COG0354	folic acid binding
Spa2297_RS15295	COG3485	protocatechuate 3,4-dioxygenase
Spa2297_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS15365	COG2897	thiosulfate sulfurtransferase activity
Spa2297_RS15390	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS15395	COG1609	Transcriptional regulator
Spa2297_RS15400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spa2297_RS15415	COG0737	Belongs to the 5'-nucleotidase family
Spa2297_RS15420	COG0456	acetyltransferase
Spa2297_RS15450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Spa2297_RS15460	COG0406	alpha-ribazole phosphatase activity
Spa2297_RS15460	COG0494	nUDIX hydrolase
Spa2297_RS15480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Spa2297_RS15485	COG0306	phosphate transporter
Spa2297_RS15495	COG1937	Protein conserved in bacteria
Spa2297_RS15505	COG0277	FAD linked oxidase domain protein
Spa2297_RS15510	COG0671	phosphoesterase, PA-phosphatase related
Spa2297_RS15515	COG1196	nuclear chromosome segregation
Spa2297_RS15515	COG0741	lytic transglycosylase activity
Spa2297_RS15515	COG0739	heme binding
Spa2297_RS15550	COG0456	acetyltransferase
Spa2297_RS15550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Spa2297_RS15555	COG4585	Histidine kinase
Spa2297_RS15560	COG2197	response regulator
Spa2297_RS15600	COG1252	NADH dehydrogenase
Spa2297_RS15630	COG0579	oxidoreductase
Spa2297_RS15635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Spa2297_RS15665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Spa2297_RS15665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Spa2297_RS15675	COG2249	NAD(P)H dehydrogenase (quinone) activity
Spa2297_RS15690	COG0513	Belongs to the DEAD box helicase family
Spa2297_RS15725	COG1643	Atp-dependent helicase
Spa2297_RS15760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Spa2297_RS15790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Spa2297_RS15795	COG0047	phosphoribosylformylglycinamidine synthase activity
Spa2297_RS15800	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Spa2297_RS15835	COG2197	response regulator
Spa2297_RS15845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Spa2297_RS15860	COG0151	Belongs to the GarS family
Spa2297_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS15940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Spa2297_RS15980	COG1191	sigma factor activity
Spa2297_RS15985	COG1191	sigma factor activity
Spa2297_RS16005	COG2353	YceI-like domain
Spa2297_RS16025	COG3467	pyridoxamine 5'-phosphate
Spa2297_RS16035	COG0477	Major facilitator Superfamily
Spa2297_RS16040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Spa2297_RS16050	COG2205	protein histidine kinase activity
Spa2297_RS16055	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS16070	COG1733	regulation of RNA biosynthetic process
Spa2297_RS16075	COG0768	penicillin binding
Spa2297_RS16095	COG0784	Response regulator, receiver
Spa2297_RS16100	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS16105	COG1595	DNA-templated transcription, initiation
Spa2297_RS16135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spa2297_RS16150	COG0653	protein targeting
Spa2297_RS16170	COG0006	proline dipeptidase activity
Spa2297_RS16190	COG1999	signal sequence binding
Spa2297_RS16205	COG2837	iron assimilation
Spa2297_RS16210	COG0077	Prephenate dehydratase
Spa2297_RS16215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Spa2297_RS16220	COG0561	phosphatase activity
Spa2297_RS16245	COG1131	(ABC) transporter
Spa2297_RS16260	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Spa2297_RS16270	COG0561	phosphatase activity
Spa2297_RS16275	COG0739	heme binding
Spa2297_RS16285	COG4988	ABC transporter
Spa2297_RS16290	COG1294	oxidase, subunit
Spa2297_RS16295	COG1271	oxidase subunit
Spa2297_RS16305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Spa2297_RS16310	COG1609	Transcriptional regulator
Spa2297_RS16315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Spa2297_RS16330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Spa2297_RS16355	COG0662	Cupin 2, conserved barrel domain protein
Spa2297_RS16360	COG1950	PFAM Membrane protein of
Spa2297_RS16365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spa2297_RS16370	COG0626	cystathionine gamma-synthase activity
Spa2297_RS16395	COG2814	Major facilitator Superfamily
Spa2297_RS16415	COG0305	Participates in initiation and elongation during chromosome replication
Spa2297_RS16425	COG0359	binds to the 23S rRNA
Spa2297_RS16430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Spa2297_RS16435	COG0629	single-stranded DNA binding
Spa2297_RS16440	COG0360	Binds together with S18 to 16S ribosomal RNA
Spa2297_RS16465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Spa2297_RS16475	COG1260	myo-inositol-1-phosphate synthase
Spa2297_RS16495	COG0617	tRNA 3'-terminal CCA addition
Spa2297_RS16510	COG2815	serine threonine protein kinase
Spa2297_RS16510	COG0515	serine threonine protein kinase
Spa2297_RS16515	COG1595	DNA-templated transcription, initiation
Spa2297_RS16525	COG0492	ferredoxin-NADP+ reductase activity
Spa2297_RS16530	COG3118	belongs to the thioredoxin family
Spa2297_RS16545	COG1192	Involved in chromosome partitioning
Spa2297_RS16550	COG0357	Ribosomal RNA small subunit methyltransferase G
Spa2297_RS16560	COG0706	membrane insertase activity
Spa2297_RS16565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Spa2297_RS16570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Spa2297_RS16575	COG0592	DNA-directed DNA polymerase activity
Spa2297_RS16580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Spa2297_RS16585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Spa2297_RS16590	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
Spa2297_RS16595	COG0187	DNA topoisomerase II activity
Spa2297_RS16600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Spa2297_RS16615	COG2319	Wd-40 repeat
Spa2297_RS16615	COG4249	Peptidase C14 caspase catalytic subunit p20
Spa2297_RS16645	COG0515	serine threonine protein kinase
Spa2297_RS16660	COG2205	protein histidine kinase activity
Spa2297_RS16665	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS16675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Spa2297_RS16690	COG0705	Rhomboid family
Spa2297_RS16710	COG3764	Sortase (surface protein transpeptidase)
Spa2297_RS16715	COG3764	Sortase (surface protein transpeptidase)
Spa2297_RS16720	COG0515	serine threonine protein kinase
Spa2297_RS16725	COG0768	penicillin binding
Spa2297_RS16740	COG1716	ATPase activity
Spa2297_RS16745	COG1716	ATPase activity
Spa2297_RS16770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Spa2297_RS16795	COG1250	3-hydroxyacyl-CoA dehydrogenase
Spa2297_RS16800	COG1309	transcriptional regulator
Spa2297_RS16805	COG1522	sequence-specific DNA binding
Spa2297_RS16830	COG0303	'Molybdopterin
Spa2297_RS16865	COG0515	serine threonine protein kinase
Spa2297_RS16870	COG0515	serine threonine protein kinase
Spa2297_RS16890	COG0022	dehydrogenase e1 component
Spa2297_RS16895	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spa2297_RS16935	COG1362	aminopeptidase activity
Spa2297_RS16940	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS16950	COG1741	Belongs to the pirin family
Spa2297_RS16965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Spa2297_RS16995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spa2297_RS17060	COG0366	Alpha amylase catalytic
Spa2297_RS17130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Spa2297_RS17145	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS17150	COG5002	protein histidine kinase activity
Spa2297_RS17190	COG0513	Belongs to the DEAD box helicase family
Spa2297_RS17195	COG1278	Cold shock
Spa2297_RS17230	COG2080	2 iron, 2 sulfur cluster binding
Spa2297_RS17230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Spa2297_RS17255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Spa2297_RS17260	COG1595	DNA-templated transcription, initiation
Spa2297_RS17310	COG0477	Major facilitator Superfamily
Spa2297_RS17340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Spa2297_RS17380	COG3415	Transposase
Spa2297_RS17380	COG2801	Transposase and inactivated derivatives
Spa2297_RS17445	COG0717	Belongs to the dCTP deaminase family
Spa2297_RS17450	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Spa2297_RS17470	COG2181	nitrate reductase activity
Spa2297_RS17470	COG0247	lactate metabolic process
Spa2297_RS17475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Spa2297_RS17480	COG0443	Heat shock 70 kDa protein
Spa2297_RS17485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Spa2297_RS17490	COG0484	heat shock protein binding
Spa2297_RS17495	COG0789	Transcriptional regulator
Spa2297_RS17500	COG4213	ABC transporter substrate-binding protein
Spa2297_RS17530	COG0542	response to heat
Spa2297_RS17555	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Spa2297_RS17570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Spa2297_RS17575	COG0191	fructose-bisphosphate aldolase activity
Spa2297_RS17580	COG0477	Major facilitator Superfamily
Spa2297_RS17605	COG3844	kynureninase activity
Spa2297_RS17625	COG4585	Histidine kinase
Spa2297_RS17630	COG2197	response regulator
Spa2297_RS17635	COG4585	Histidine kinase
Spa2297_RS17640	COG2197	response regulator
Spa2297_RS17655	COG3559	Exporter of polyketide antibiotics
Spa2297_RS17660	COG1131	(ABC) transporter
Spa2297_RS17675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Spa2297_RS17690	COG1595	DNA-templated transcription, initiation
Spa2297_RS17700	COG1802	Transcriptional regulator
Spa2297_RS17720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Spa2297_RS17725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Spa2297_RS17755	COG1595	DNA-templated transcription, initiation
Spa2297_RS17780	COG1585	Membrane protein implicated in regulation of membrane protease activity
Spa2297_RS17785	COG2268	Band 7 protein
Spa2297_RS17815	COG1408	metallophosphoesterase
Spa2297_RS17825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Spa2297_RS17835	COG0003	Pfam Anion-transporting ATPase
Spa2297_RS17850	COG0596	Alpha beta hydrolase
Spa2297_RS17860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Spa2297_RS17875	COG0494	nUDIX hydrolase
Spa2297_RS17885	COG0596	Alpha beta hydrolase
Spa2297_RS17895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Spa2297_RS17900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Spa2297_RS17960	COG1111	helicase
Spa2297_RS17960	COG1205	dead DEAH box helicase
Spa2297_RS17965	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS17975	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Spa2297_RS17995	COG1754	DNA topoisomerase type I activity
Spa2297_RS17995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Spa2297_RS18000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Spa2297_RS18035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Spa2297_RS18035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Spa2297_RS18045	COG1280	lysine exporter protein (LysE YggA)
Spa2297_RS18060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Spa2297_RS18065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Spa2297_RS18070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Spa2297_RS18075	COG0254	rRNA binding
Spa2297_RS18085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Spa2297_RS18110	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS18130	COG0076	glutamate decarboxylase activity
Spa2297_RS18135	COG0789	Transcriptional regulator
Spa2297_RS18140	COG0393	Putative heavy-metal-binding
Spa2297_RS18145	COG0586	Pfam SNARE associated Golgi protein
Spa2297_RS18155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Spa2297_RS18160	COG2027	D-alanyl-D-alanine carboxypeptidase
Spa2297_RS18170	COG0037	tRNA processing
Spa2297_RS18185	COG0302	gtp cyclohydrolase
Spa2297_RS18195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Spa2297_RS18200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Spa2297_RS18240	COG0649	NAD binding
Spa2297_RS18255	COG2197	response regulator
Spa2297_RS18260	COG1660	Displays ATPase and GTPase activities
Spa2297_RS18275	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Spa2297_RS18285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Spa2297_RS18290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Spa2297_RS18300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Spa2297_RS18320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Spa2297_RS18350	COG0739	heme binding
Spa2297_RS18375	COG2205	protein histidine kinase activity
Spa2297_RS18380	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS18390	COG1595	DNA-templated transcription, initiation
Spa2297_RS18395	COG1194	a g-specific adenine glycosylase
Spa2297_RS18405	COG2197	response regulator
Spa2297_RS18410	COG0671	phosphoesterase, PA-phosphatase related
Spa2297_RS18420	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Spa2297_RS18440	COG0248	Ppx GppA phosphatase
Spa2297_RS18445	COG1082	Xylose isomerase domain protein TIM barrel
Spa2297_RS18450	COG1309	transcriptional regulator
Spa2297_RS18455	COG0129	dihydroxy-acid dehydratase activity
Spa2297_RS18480	COG0842	Transport permease protein
Spa2297_RS18480	COG1129	ABC transporter
Spa2297_RS18490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Spa2297_RS18495	COG0180	Tryptophanyl-tRNA synthetase
Spa2297_RS18530	COG2223	nitrite transmembrane transporter activity
Spa2297_RS18535	COG0123	including yeast histone deacetylase and acetoin utilization protein
Spa2297_RS18585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Spa2297_RS18590	COG0181	hydroxymethylbilane synthase activity
Spa2297_RS18595	COG1648	precorrin-2 dehydrogenase activity
Spa2297_RS18595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Spa2297_RS18610	COG0113	porphobilinogen synthase activity
Spa2297_RS18625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Spa2297_RS18635	COG0018	arginyl-trna synthetase
Spa2297_RS18640	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Spa2297_RS18660	COG1690	Belongs to the RtcB family
Spa2297_RS18675	COG1742	UPF0060 membrane protein
Spa2297_RS18680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS18685	COG0431	NADPH-dependent FMN reductase
Spa2297_RS18695	COG2205	protein histidine kinase activity
Spa2297_RS18730	COG2208	phosphoserine phosphatase activity
Spa2297_RS18730	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS18730	COG2172	sigma factor antagonist activity
Spa2297_RS18735	COG0569	domain protein
Spa2297_RS18735	COG0475	glutathione-regulated potassium exporter activity
Spa2297_RS18745	COG0659	secondary active sulfate transmembrane transporter activity
Spa2297_RS18750	COG1115	amino acid carrier protein
Spa2297_RS18765	COG4977	sequence-specific DNA binding
Spa2297_RS18780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Spa2297_RS18785	COG0406	alpha-ribazole phosphatase activity
Spa2297_RS18795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spa2297_RS18800	COG0785	Cytochrome C biogenesis protein
Spa2297_RS18805	COG1333	cytochrome c biogenesis protein
Spa2297_RS18810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Spa2297_RS18840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Spa2297_RS18845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Spa2297_RS18850	COG0163	prenyltransferase activity
Spa2297_RS18860	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Spa2297_RS18875	COG1301	dicarboxylic acid transport
Spa2297_RS18880	COG1309	transcriptional regulator
Spa2297_RS18895	COG0183	Belongs to the thiolase family
Spa2297_RS18905	COG2226	methyltransferase
Spa2297_RS18910	COG1278	Cold shock
Spa2297_RS18915	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Spa2297_RS18925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Spa2297_RS18925	COG0515	serine threonine protein kinase
Spa2297_RS18930	COG1674	ftsk spoiiie
Spa2297_RS19035	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Spa2297_RS19155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Spa2297_RS19165	COG2226	methyltransferase
Spa2297_RS19185	COG0242	peptide deformylase activity
Spa2297_RS19200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spa2297_RS19205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spa2297_RS19210	COG0649	NAD binding
Spa2297_RS19220	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Spa2297_RS19225	COG1034	ATP synthesis coupled electron transport
Spa2297_RS19230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Spa2297_RS19235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spa2297_RS19245	COG0713	ATP synthesis coupled electron transport
Spa2297_RS19250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Spa2297_RS19260	COG1007	ATP synthesis coupled electron transport
Spa2297_RS19270	COG0514	ATP-dependent DNA helicase (RecQ)
Spa2297_RS19275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Spa2297_RS19285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Spa2297_RS19300	COG2188	Transcriptional regulator
Spa2297_RS19315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Spa2297_RS19355	COG0561	phosphatase activity
Spa2297_RS19365	COG0142	geranyltranstransferase activity
Spa2297_RS19375	COG1131	(ABC) transporter
Spa2297_RS19385	COG0655	NAD(P)H dehydrogenase (quinone) activity
Spa2297_RS19415	COG0702	epimerase
Spa2297_RS19420	COG1013	pyruvate-flavodoxin oxidoreductase activity
Spa2297_RS19425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Spa2297_RS19425	COG0674	pyruvate-flavodoxin oxidoreductase activity
Spa2297_RS19445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spa2297_RS19450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spa2297_RS19455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spa2297_RS19460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Spa2297_RS19465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Spa2297_RS19475	COG0713	ATP synthesis coupled electron transport
Spa2297_RS19480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Spa2297_RS19490	COG1007	ATP synthesis coupled electron transport
Spa2297_RS19495	COG0501	Belongs to the peptidase M48B family
Spa2297_RS19500	COG3304	Inner membrane component domain
Spa2297_RS19515	COG2261	transglycosylase associated protein
Spa2297_RS19520	COG1666	GTP binding
Spa2297_RS19540	COG0702	epimerase
Spa2297_RS19545	COG0402	S-adenosylhomocysteine deaminase activity
Spa2297_RS19560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Spa2297_RS19565	COG2030	dehydratase
Spa2297_RS19580	COG0477	Major facilitator Superfamily
Spa2297_RS19585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Spa2297_RS19590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Spa2297_RS19595	COG0436	Aminotransferase
Spa2297_RS19605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Spa2297_RS19610	COG0250	Participates in transcription elongation, termination and antitermination
Spa2297_RS19615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Spa2297_RS19620	COG0081	regulation of translation
Spa2297_RS19635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Spa2297_RS19640	COG0222	ribosome binding
Spa2297_RS19645	COG0085	RNA polymerase activity
Spa2297_RS19650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Spa2297_RS19660	COG0463	Glycosyl transferase, family 2
Spa2297_RS19665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Spa2297_RS19670	COG0049	tRNA binding
Spa2297_RS19675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Spa2297_RS19680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Spa2297_RS19690	COG0577	efflux transmembrane transporter activity
Spa2297_RS19690	COG1136	(ABC) transporter
Spa2297_RS19700	COG2197	response regulator
Spa2297_RS19745	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS19750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Spa2297_RS19780	COG3209	COG3209 Rhs family protein
Spa2297_RS19790	COG0051	transcription antitermination factor activity, RNA binding
Spa2297_RS19795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Spa2297_RS19800	COG0088	Forms part of the polypeptide exit tunnel
Spa2297_RS19805	COG0089	rRNA binding
Spa2297_RS19810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Spa2297_RS19815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Spa2297_RS19820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Spa2297_RS19825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Spa2297_RS19830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Spa2297_RS19835	COG0255	Belongs to the universal ribosomal protein uL29 family
Spa2297_RS19840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Spa2297_RS19845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Spa2297_RS19850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Spa2297_RS19855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Spa2297_RS19860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Spa2297_RS19865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Spa2297_RS19870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Spa2297_RS19875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Spa2297_RS19880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Spa2297_RS19885	COG1841	ribosomal large subunit assembly
Spa2297_RS19890	COG0200	Binds to the 23S rRNA
Spa2297_RS19895	COG0201	protein transport
Spa2297_RS19900	COG0563	adenylate kinase activity
Spa2297_RS19910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Spa2297_RS19915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Spa2297_RS19920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Spa2297_RS19925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Spa2297_RS19930	COG0202	RNA polymerase activity
Spa2297_RS19935	COG0203	ribosomal protein L17
Spa2297_RS19940	COG0101	tRNA pseudouridine synthase activity
Spa2297_RS19955	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Spa2297_RS19960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Spa2297_RS19965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Spa2297_RS19975	COG1072	(Pantothenic acid kinase))
Spa2297_RS19985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Spa2297_RS20000	COG0736	holo-[acyl-carrier-protein] synthase activity
Spa2297_RS20005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Spa2297_RS20015	COG0802	atpase or kinase
Spa2297_RS20025	COG0456	acetyltransferase
Spa2297_RS20025	COG1214	PFAM Peptidase M22, glycoprotease
Spa2297_RS20035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Spa2297_RS20045	COG1609	Transcriptional regulator
Spa2297_RS20060	COG4941	Belongs to the sigma-70 factor family
Spa2297_RS20070	COG0726	polysaccharide deacetylase
Spa2297_RS20075	COG0726	polysaccharide deacetylase
Spa2297_RS20080	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Spa2297_RS20085	COG0459	protein refolding
Spa2297_RS20090	COG4221	oxidoreductase activity
Spa2297_RS20100	COG0583	DNA-binding transcription factor activity
Spa2297_RS20115	COG1595	DNA-templated transcription, initiation
Spa2297_RS20125	COG0516	GMP reductase activity
Spa2297_RS20135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Spa2297_RS20145	COG0515	serine threonine protein kinase
Spa2297_RS20145	COG2815	serine threonine protein kinase
Spa2297_RS20150	COG0515	serine threonine protein kinase
Spa2297_RS20155	COG2815	serine threonine protein kinase
Spa2297_RS20155	COG0515	serine threonine protein kinase
Spa2297_RS20160	COG0515	serine threonine protein kinase
Spa2297_RS20165	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS20180	COG0519	Catalyzes the synthesis of GMP from XMP
Spa2297_RS20180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Spa2297_RS20220	COG2197	response regulator
Spa2297_RS20250	COG0739	heme binding
Spa2297_RS20260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS20260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS20275	COG0714	Associated with various cellular activities
Spa2297_RS20280	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Spa2297_RS20285	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Spa2297_RS20295	COG0045	succinate-CoA ligase (ADP-forming) activity
Spa2297_RS20325	COG0138	bifunctional purine biosynthesis protein purh
Spa2297_RS20345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Spa2297_RS20360	COG0039	L-malate dehydrogenase activity
Spa2297_RS20365	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS20375	COG0517	IMP dehydrogenase activity
Spa2297_RS20375	COG4175	Glycine betaine
Spa2297_RS20395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Spa2297_RS20400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Spa2297_RS20405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Spa2297_RS20415	COG0754	glutathionylspermidine amidase activity
Spa2297_RS20420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Spa2297_RS20425	COG0180	Tryptophanyl-tRNA synthetase
Spa2297_RS20445	COG0671	phosphoesterase, PA-phosphatase related
Spa2297_RS20460	COG1295	ribonuclease BN
Spa2297_RS20465	COG1686	Belongs to the peptidase S11 family
Spa2297_RS20475	COG1408	metallophosphoesterase
Spa2297_RS20520	COG1053	succinate dehydrogenase
Spa2297_RS20530	COG2009	succinate dehydrogenase
Spa2297_RS20560	COG1595	DNA-templated transcription, initiation
Spa2297_RS20575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS20575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS20620	COG1216	Glycosyl transferase, family 2
Spa2297_RS20640	COG1216	Glycosyl transferase, family 2
Spa2297_RS20655	COG2089	acid synthase
Spa2297_RS20665	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Spa2297_RS20665	COG1473	amidohydrolase
Spa2297_RS20670	COG1744	ABC transporter substrate-binding protein PnrA-like
Spa2297_RS20675	COG1744	ABC transporter substrate-binding protein PnrA-like
Spa2297_RS20680	COG3845	ABC transporter
Spa2297_RS20685	COG4603	Belongs to the binding-protein-dependent transport system permease family
Spa2297_RS20690	COG1079	Belongs to the binding-protein-dependent transport system permease family
Spa2297_RS20725	COG2814	Major facilitator Superfamily
Spa2297_RS20730	COG0583	DNA-binding transcription factor activity
Spa2297_RS20740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Spa2297_RS20765	COG2205	protein histidine kinase activity
Spa2297_RS20770	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS20775	COG1595	DNA-templated transcription, initiation
Spa2297_RS20790	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS20795	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS20810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Spa2297_RS20835	COG4770	biotin carboxylase activity
Spa2297_RS20845	COG0424	maF-like protein
Spa2297_RS20850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Spa2297_RS20860	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Spa2297_RS20870	COG1024	Enoyl-CoA hydratase
Spa2297_RS20880	COG2986	histidine ammonia-lyase
Spa2297_RS20905	COG1136	(ABC) transporter
Spa2297_RS20915	COG1064	alcohol dehydrogenase
Spa2297_RS20920	COG1090	epimerase
Spa2297_RS20925	COG0667	Aldo Keto reductase
Spa2297_RS20950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Spa2297_RS20975	COG2255	four-way junction helicase activity
Spa2297_RS20980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Spa2297_RS20995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Spa2297_RS21005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Spa2297_RS21035	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Spa2297_RS21055	COG1331	Highly conserved protein containing a thioredoxin domain
Spa2297_RS21070	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Spa2297_RS21100	COG0436	Aminotransferase
Spa2297_RS21105	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Spa2297_RS21120	COG1414	Transcriptional regulator
Spa2297_RS21125	COG0251	oxidation-reduction process
Spa2297_RS21130	COG2610	gluconate transmembrane transporter activity
Spa2297_RS21165	COG2894	cell division
Spa2297_RS21270	COG2226	methyltransferase
Spa2297_RS21280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Spa2297_RS21285	COG0741	lytic transglycosylase activity
Spa2297_RS21295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Spa2297_RS21300	COG0450	alkyl hydroperoxide reductase
Spa2297_RS21315	COG1136	(ABC) transporter
Spa2297_RS21335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Spa2297_RS21350	COG0114	fumarate hydratase activity
Spa2297_RS21355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Spa2297_RS21355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Spa2297_RS21380	COG0778	Nitroreductase
Spa2297_RS21405	COG1722	exodeoxyribonuclease VII activity
Spa2297_RS21410	COG1570	exodeoxyribonuclease VII activity
Spa2297_RS21420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Spa2297_RS21435	COG0012	GTP binding
Spa2297_RS21465	COG2318	DinB family
Spa2297_RS21470	COG2813	Specifically methylates the guanine in position
Spa2297_RS21535	COG1053	succinate dehydrogenase
Spa2297_RS21555	COG1217	gtp-binding protein TYPA
Spa2297_RS21560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spa2297_RS21565	COG4166	transmembrane transport
Spa2297_RS21575	COG0444	Belongs to the ABC transporter superfamily
Spa2297_RS21580	COG4608	Belongs to the ABC transporter superfamily
Spa2297_RS21590	COG0601	transmembrane transport
Spa2297_RS21595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spa2297_RS21600	COG0444	Belongs to the ABC transporter superfamily
Spa2297_RS21605	COG4608	Belongs to the ABC transporter superfamily
Spa2297_RS21620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Spa2297_RS21665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spa2297_RS21675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Spa2297_RS21685	COG0519	Catalyzes the synthesis of GMP from XMP
Spa2297_RS21690	COG1024	Enoyl-CoA hydratase
Spa2297_RS21705	COG1595	DNA-templated transcription, initiation
Spa2297_RS21715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spa2297_RS21720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Spa2297_RS21755	COG0598	Magnesium transport protein CorA
Spa2297_RS21765	COG2814	Major facilitator Superfamily
Spa2297_RS21780	COG2095	MarC family integral membrane protein
Spa2297_RS21785	COG1432	Conserved Protein
Spa2297_RS21795	COG0513	Belongs to the DEAD box helicase family
Spa2297_RS21890	COG0210	DNA helicase
Spa2297_RS21900	COG2816	NAD+ diphosphatase activity
Spa2297_RS21930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Spa2297_RS21975	COG3480	Lon protease (S16) C-terminal proteolytic domain
Spa2297_RS21985	COG1615	UPF0182 protein
Spa2297_RS22010	COG0753	catalase activity
Spa2297_RS22020	COG0483	inositol monophosphate 1-phosphatase activity
Spa2297_RS22030	COG2076	Multidrug Resistance protein
Spa2297_RS22040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Spa2297_RS22050	COG2135	peptidase activity
Spa2297_RS22060	COG1595	DNA-templated transcription, initiation
Spa2297_RS22065	COG5662	AntiSigma factor
Spa2297_RS22085	COG0242	peptide deformylase activity
Spa2297_RS22095	COG2124	cytochrome p450
Spa2297_RS22115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Spa2297_RS22115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Spa2297_RS22135	COG2188	Transcriptional regulator
Spa2297_RS22140	COG2182	Extracellular solute-binding protein
Spa2297_RS22145	COG1175	transmembrane transport
Spa2297_RS22150	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS22155	COG1472	Belongs to the glycosyl hydrolase 3 family
Spa2297_RS22160	COG0363	glucosamine-6-phosphate deaminase activity
Spa2297_RS22175	COG1597	lipid kinase activity
Spa2297_RS22215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Spa2297_RS22220	COG0142	geranyltranstransferase activity
Spa2297_RS22250	COG4106	trans-aconitate 2-methyltransferase activity
Spa2297_RS22255	COG1126	abc transporter atp-binding protein
Spa2297_RS22270	COG0281	malic enzyme
Spa2297_RS22275	COG0604	alcohol dehydrogenase
Spa2297_RS22310	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spa2297_RS22310	COG0567	Dehydrogenase, E1 component
Spa2297_RS22315	COG2205	protein histidine kinase activity
Spa2297_RS22320	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS22330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Spa2297_RS22385	COG1309	transcriptional regulator
Spa2297_RS22395	COG0768	penicillin binding
Spa2297_RS22410	COG2205	protein histidine kinase activity
Spa2297_RS22425	COG1793	dna ligase
Spa2297_RS22425	COG3285	dna ligase
Spa2297_RS22430	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Spa2297_RS22445	COG3467	pyridoxamine 5'-phosphate
Spa2297_RS22455	COG2867	negative regulation of translational initiation
Spa2297_RS22460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spa2297_RS22465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spa2297_RS22470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spa2297_RS22475	COG0662	Cupin 2, conserved barrel domain protein
Spa2297_RS22480	COG2329	Antibiotic biosynthesis monooxygenase
Spa2297_RS22485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Spa2297_RS22505	COG2318	DinB family
Spa2297_RS22520	COG0210	DNA helicase
Spa2297_RS22570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Spa2297_RS22585	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS22590	COG0018	arginyl-trna synthetase
Spa2297_RS22595	COG0019	diaminopimelate decarboxylase activity
Spa2297_RS22600	COG0460	homoserine dehydrogenase
Spa2297_RS22605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Spa2297_RS22610	COG0083	homoserine kinase activity
Spa2297_RS22625	COG1316	TRANSCRIPTIONal
Spa2297_RS22630	COG0254	rRNA binding
Spa2297_RS22635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Spa2297_RS22640	COG2890	protein-(glutamine-N5) methyltransferase activity
Spa2297_RS22650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spa2297_RS22655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Spa2297_RS22660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Spa2297_RS22675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Spa2297_RS22680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Spa2297_RS22685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Spa2297_RS22690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Spa2297_RS22695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Spa2297_RS22700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Spa2297_RS22705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Spa2297_RS22720	COG2197	response regulator
Spa2297_RS22725	COG4585	Histidine kinase
Spa2297_RS22755	COG1250	3-hydroxyacyl-CoA dehydrogenase
Spa2297_RS22770	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Spa2297_RS22805	COG1131	(ABC) transporter
Spa2297_RS22825	COG0183	Belongs to the thiolase family
Spa2297_RS22845	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS22850	COG2205	protein histidine kinase activity
Spa2297_RS22895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS22895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS22930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Spa2297_RS22935	COG0280	phosphate acetyltransferase
Spa2297_RS22935	COG0857	belongs to the CobB CobQ family
Spa2297_RS22940	COG0205	6-phosphofructokinase activity
Spa2297_RS22950	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS22955	COG1175	transmembrane transport
Spa2297_RS22960	COG1653	transport
Spa2297_RS22970	COG4565	transcriptional regulatory protein
Spa2297_RS22975	COG3290	protein histidine kinase activity
Spa2297_RS22980	COG1301	dicarboxylic acid transport
Spa2297_RS22990	COG3118	belongs to the thioredoxin family
Spa2297_RS22990	COG0492	ferredoxin-NADP+ reductase activity
Spa2297_RS23000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Spa2297_RS23005	COG3281	Trehalose synthase
Spa2297_RS23010	COG0366	Alpha amylase catalytic
Spa2297_RS23015	COG0366	Alpha amylase catalytic
Spa2297_RS23020	COG0058	SHG alpha-glucan phosphorylase activity
Spa2297_RS23040	COG1132	(ABC) transporter
Spa2297_RS23045	COG1132	(ABC) transporter
Spa2297_RS23050	COG1132	(ABC) transporter
Spa2297_RS23055	COG1132	(ABC) transporter
Spa2297_RS23065	COG1376	ErfK ybiS ycfS ynhG family protein
Spa2297_RS23070	COG1376	ErfK ybiS ycfS ynhG family protein
Spa2297_RS23075	COG1024	Enoyl-CoA hydratase
Spa2297_RS23095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Spa2297_RS23100	COG3757	hydrolase, family 25
Spa2297_RS23100	COG3409	Peptidoglycan-binding domain 1 protein
Spa2297_RS23120	COG1760	l-serine dehydratase
Spa2297_RS23125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Spa2297_RS23130	COG0509	glycine decarboxylation via glycine cleavage system
Spa2297_RS23135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Spa2297_RS23155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spa2297_RS23160	COG4166	transmembrane transport
Spa2297_RS23170	COG0444	Belongs to the ABC transporter superfamily
Spa2297_RS23175	COG4608	Belongs to the ABC transporter superfamily
Spa2297_RS23180	COG2860	membrane
Spa2297_RS23190	COG0789	Transcriptional regulator
Spa2297_RS23220	COG0482	sulfurtransferase activity
Spa2297_RS23235	COG1611	Belongs to the LOG family
Spa2297_RS23250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Spa2297_RS23260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Spa2297_RS23265	COG0154	amidase activity
Spa2297_RS23275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Spa2297_RS23280	COG2409	Drug exporters of the RND superfamily
Spa2297_RS23285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Spa2297_RS23300	COG2197	response regulator
Spa2297_RS23310	COG2133	pyrroloquinoline quinone binding
Spa2297_RS23315	COG0667	Aldo Keto reductase
Spa2297_RS23325	COG5001	Diguanylate cyclase
Spa2297_RS23335	COG0440	acetolactate synthase activity
Spa2297_RS23340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Spa2297_RS23345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Spa2297_RS23350	COG0477	Major facilitator Superfamily
Spa2297_RS23365	COG0506	proline dehydrogenase activity
Spa2297_RS23370	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS23375	COG0473	3-isopropylmalate dehydrogenase activity
Spa2297_RS23380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Spa2297_RS23390	COG0831	urea catabolic process
Spa2297_RS23390	COG0832	Belongs to the urease beta subunit family
Spa2297_RS23395	COG0804	urea catabolic process
Spa2297_RS23400	COG2957	Belongs to the agmatine deiminase family
Spa2297_RS23410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Spa2297_RS23430	COG1335	isochorismatase
Spa2297_RS23445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Spa2297_RS23465	COG2018	Roadblock/LC7 domain
Spa2297_RS23485	COG2018	Roadblock/LC7 domain
Spa2297_RS23490	COG5002	protein histidine kinase activity
Spa2297_RS23500	COG0179	Fumarylacetoacetate (FAA) hydrolase
Spa2297_RS23505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Spa2297_RS23540	COG1414	Transcriptional regulator
Spa2297_RS23545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Spa2297_RS23550	COG0066	3-isopropylmalate dehydratase activity
Spa2297_RS23560	COG0776	regulation of translation
Spa2297_RS23570	COG1920	GTP binding
Spa2297_RS23580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Spa2297_RS23585	COG1181	Belongs to the D-alanine--D-alanine ligase family
Spa2297_RS23600	COG0351	phosphomethylpyrimidine kinase
Spa2297_RS23610	COG1461	Dihydroxyacetone kinase
Spa2297_RS23620	COG0742	ribosomal rna small subunit methyltransferase
Spa2297_RS23625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Spa2297_RS23640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Spa2297_RS23645	COG0571	ribonuclease III activity
Spa2297_RS23650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Spa2297_RS23655	COG1733	regulation of RNA biosynthetic process
Spa2297_RS23660	COG2340	Cysteine-rich secretory protein family
Spa2297_RS23665	COG1254	Belongs to the acylphosphatase family
Spa2297_RS23675	COG1196	nuclear chromosome segregation
Spa2297_RS23680	COG0477	Major facilitator Superfamily
Spa2297_RS23720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Spa2297_RS23740	COG0228	four-way junction DNA binding
Spa2297_RS23745	COG1837	Belongs to the UPF0109 family
Spa2297_RS23750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Spa2297_RS23755	COG0336	Belongs to the RNA methyltransferase TrmD family
Spa2297_RS23760	COG0335	large ribosomal subunit rRNA binding
Spa2297_RS23765	COG0681	Belongs to the peptidase S26 family
Spa2297_RS23770	COG0681	Belongs to the peptidase S26 family
Spa2297_RS23775	COG0681	Belongs to the peptidase S26 family
Spa2297_RS23790	COG0792	nuclease activity
Spa2297_RS23805	COG1191	sigma factor activity
Spa2297_RS23820	COG0052	Belongs to the universal ribosomal protein uS2 family
Spa2297_RS23825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Spa2297_RS23830	COG0528	UMP kinase activity
Spa2297_RS23835	COG0233	cytoplasmic translational termination
Spa2297_RS23840	COG0575	Belongs to the CDS family
Spa2297_RS23845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Spa2297_RS23855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Spa2297_RS23860	COG3842	ATPase activity
Spa2297_RS23880	COG1136	(ABC) transporter
Spa2297_RS23885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Spa2297_RS23895	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS23905	COG0584	glycerophosphoryl diester phosphodiesterase
Spa2297_RS23910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Spa2297_RS23970	COG0134	indole-3-glycerol-phosphate synthase activity
Spa2297_RS23975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Spa2297_RS23980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Spa2297_RS23985	COG0512	Glutamine amidotransferase of anthranilate synthase
Spa2297_RS23995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Spa2297_RS24015	COG3842	ATPase activity
Spa2297_RS24020	COG1176	ABC-type spermidine putrescine transport system, permease component I
Spa2297_RS24025	COG1177	transmembrane transport
Spa2297_RS24030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Spa2297_RS24070	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS24090	COG4585	Histidine kinase
Spa2297_RS24095	COG2197	response regulator
Spa2297_RS24105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Spa2297_RS24110	COG0750	zinc metalloprotease
Spa2297_RS24115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Spa2297_RS24130	COG0442	prolyl-tRNA aminoacylation
Spa2297_RS24150	COG0779	Required for maturation of 30S ribosomal subunits
Spa2297_RS24160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Spa2297_RS24170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Spa2297_RS24175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Spa2297_RS24190	COG4608	Belongs to the ABC transporter superfamily
Spa2297_RS24205	COG0601	transmembrane transport
Spa2297_RS24210	COG0747	negative chemotaxis
Spa2297_RS24215	COG0455	bacterial-type flagellum organization
Spa2297_RS24225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Spa2297_RS24230	COG1185	polyribonucleotide nucleotidyltransferase activity
Spa2297_RS24235	COG0612	Peptidase, M16
Spa2297_RS24240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Spa2297_RS24260	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Spa2297_RS24265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spa2297_RS24270	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Spa2297_RS24305	COG2770	Histidine kinase
Spa2297_RS24305	COG2208	phosphoserine phosphatase activity
Spa2297_RS24310	COG2205	protein histidine kinase activity
Spa2297_RS24310	COG0784	Response regulator, receiver
Spa2297_RS24320	COG1674	ftsk spoiiie
Spa2297_RS24330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spa2297_RS24340	COG1058	Belongs to the CinA family
Spa2297_RS24340	COG1546	Belongs to the CinA family
Spa2297_RS24345	COG1396	sequence-specific DNA binding
Spa2297_RS24350	COG0783	Belongs to the Dps family
Spa2297_RS24360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Spa2297_RS24365	COG1201	RNA secondary structure unwinding
Spa2297_RS24370	COG1917	Cupin 2, conserved barrel domain protein
Spa2297_RS24370	COG2207	Transcriptional regulator
Spa2297_RS24395	COG0628	permease
Spa2297_RS24405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Spa2297_RS24415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Spa2297_RS24430	COG0765	amino acid transport
Spa2297_RS24435	COG0765	amino acid transport
Spa2297_RS24440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Spa2297_RS24445	COG1126	abc transporter atp-binding protein
Spa2297_RS24450	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS24455	COG2205	protein histidine kinase activity
Spa2297_RS24480	COG3851	Histidine kinase
Spa2297_RS24485	COG2197	response regulator
Spa2297_RS24490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spa2297_RS24510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Spa2297_RS24520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Spa2297_RS24525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Spa2297_RS24535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Spa2297_RS24570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Spa2297_RS24575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Spa2297_RS24580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Spa2297_RS24615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Spa2297_RS24645	COG3842	ATPase activity
Spa2297_RS24650	COG2186	Transcriptional regulator
Spa2297_RS24655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spa2297_RS24670	COG0187	DNA topoisomerase II activity
Spa2297_RS24685	COG2197	response regulator
Spa2297_RS24695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spa2297_RS24700	COG4565	transcriptional regulatory protein
Spa2297_RS24705	COG3290	protein histidine kinase activity
Spa2297_RS24720	COG0372	Belongs to the citrate synthase family
Spa2297_RS24740	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Spa2297_RS24745	COG0612	Peptidase, M16
Spa2297_RS24760	COG1802	Transcriptional regulator
Spa2297_RS24765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spa2297_RS24785	COG1435	thymidine kinase activity
Spa2297_RS24820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Spa2297_RS24830	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS24835	COG2205	protein histidine kinase activity
Spa2297_RS24860	COG0756	dUTP diphosphatase activity
Spa2297_RS24870	COG4591	ABC-type transport system involved in lipoprotein release permease component
Spa2297_RS24870	COG1136	(ABC) transporter
Spa2297_RS24900	COG0569	domain protein
Spa2297_RS24905	COG0531	amino acid
Spa2297_RS24910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Spa2297_RS25005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Spa2297_RS25010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Spa2297_RS25030	COG0477	Major facilitator Superfamily
Spa2297_RS25035	COG1122	ATPase activity
Spa2297_RS25045	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Spa2297_RS25050	COG0310	cobalt ion transport
Spa2297_RS25055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Spa2297_RS25070	COG1799	cell septum assembly
Spa2297_RS25100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Spa2297_RS25105	COG0475	glutathione-regulated potassium exporter activity
Spa2297_RS25110	COG2235	arginine
Spa2297_RS25115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Spa2297_RS25120	COG0531	amino acid
Spa2297_RS25130	COG1024	Enoyl-CoA hydratase
Spa2297_RS25225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Spa2297_RS25230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Spa2297_RS25245	COG1653	transport
Spa2297_RS25250	COG1175	transmembrane transport
Spa2297_RS25255	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS25260	COG1940	carbohydrate kinase activity
Spa2297_RS25265	COG4213	ABC transporter substrate-binding protein
Spa2297_RS25275	COG4214	carbohydrate transport
Spa2297_RS25280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Spa2297_RS25285	COG0531	amino acid
Spa2297_RS25305	COG1316	TRANSCRIPTIONal
Spa2297_RS25310	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS25315	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS25320	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS25325	COG0438	transferase activity, transferring glycosyl groups
Spa2297_RS25335	COG1250	3-hydroxyacyl-CoA dehydrogenase
Spa2297_RS25335	COG1024	Enoyl-CoA hydratase
Spa2297_RS25340	COG0183	Belongs to the thiolase family
Spa2297_RS25345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Spa2297_RS25360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Spa2297_RS25370	COG1472	Belongs to the glycosyl hydrolase 3 family
Spa2297_RS25405	COG0446	pyridine nucleotide-disulphide oxidoreductase
Spa2297_RS25415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Spa2297_RS25420	COG3253	May function as heme-dependent peroxidase
Spa2297_RS25435	COG3220	belongs to the UPF0276 family
Spa2297_RS25455	COG0726	polysaccharide deacetylase
Spa2297_RS25465	COG0330	HflC and HflK could
Spa2297_RS25500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Spa2297_RS25505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Spa2297_RS25510	COG2205	protein histidine kinase activity
Spa2297_RS25515	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS25550	COG1017	nitric oxide dioxygenase activity
Spa2297_RS25550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Spa2297_RS25560	COG1174	glycine betaine transport
Spa2297_RS25565	COG1174	glycine betaine transport
Spa2297_RS25600	COG1309	transcriptional regulator
Spa2297_RS25620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Spa2297_RS25645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Spa2297_RS25650	COG1181	Belongs to the D-alanine--D-alanine ligase family
Spa2297_RS25720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Spa2297_RS25750	COG1116	anion transmembrane transporter activity
Spa2297_RS25770	COG0529	Catalyzes the synthesis of activated sulfate
Spa2297_RS25775	COG0175	sulfate reduction
Spa2297_RS25805	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS25865	COG1131	(ABC) transporter
Spa2297_RS25935	COG0784	Response regulator, receiver
Spa2297_RS25940	COG4251	negative regulation of phosphorylation
Spa2297_RS25945	COG2040	homocysteine
Spa2297_RS25955	COG4585	Histidine kinase
Spa2297_RS25960	COG2197	response regulator
Spa2297_RS25995	COG0277	FAD linked oxidase domain protein
Spa2297_RS26030	COG0038	chloride channel
Spa2297_RS26055	COG1309	transcriptional regulator
Spa2297_RS26060	COG1162	GTPase activity
Spa2297_RS26070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Spa2297_RS26090	COG0028	Belongs to the TPP enzyme family
Spa2297_RS26110	COG1802	Transcriptional regulator
Spa2297_RS26115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Spa2297_RS26125	COG2197	response regulator
Spa2297_RS26160	COG3835	regulator
Spa2297_RS26175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Spa2297_RS26180	COG2252	PERMEase
Spa2297_RS26205	COG0297	glycogen (starch) synthase activity
Spa2297_RS26240	COG1295	ribonuclease BN
Spa2297_RS26260	COG2197	response regulator
Spa2297_RS26265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Spa2297_RS26270	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS26280	COG3960	tartronate-semialdehyde synthase activity
Spa2297_RS26295	COG0753	catalase activity
Spa2297_RS26300	COG2084	Dehydrogenase
Spa2297_RS26305	COG3622	Belongs to the hyi family
Spa2297_RS26325	COG2351	hydroxyisourate hydrolase activity
Spa2297_RS26335	COG2233	PERMEase
Spa2297_RS26345	COG2233	PERMEase
Spa2297_RS26350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Spa2297_RS26360	COG0406	alpha-ribazole phosphatase activity
Spa2297_RS26370	COG1733	regulation of RNA biosynthetic process
Spa2297_RS26385	COG4264	IucA IucC family
Spa2297_RS26415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Spa2297_RS26430	COG1414	Transcriptional regulator
Spa2297_RS26435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Spa2297_RS26440	COG4266	Belongs to the allantoicase family
Spa2297_RS26445	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS26475	COG2197	response regulator
Spa2297_RS26480	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS26485	COG2188	Transcriptional regulator
Spa2297_RS26505	COG1940	carbohydrate kinase activity
Spa2297_RS26515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Spa2297_RS26525	COG2197	response regulator
Spa2297_RS26530	COG4585	Histidine kinase
Spa2297_RS26540	COG1472	Belongs to the glycosyl hydrolase 3 family
Spa2297_RS26565	COG2267	carboxylic ester hydrolase activity
Spa2297_RS26580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Spa2297_RS26620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spa2297_RS26630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spa2297_RS26655	COG0657	acetylesterase activity
Spa2297_RS26680	COG0736	holo-[acyl-carrier-protein] synthase activity
Spa2297_RS26690	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS26700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Spa2297_RS26705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Spa2297_RS26725	COG0405	Gamma-glutamyltransferase
Spa2297_RS26730	COG0542	response to heat
Spa2297_RS26755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Spa2297_RS26770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Spa2297_RS26780	COG1953	Uracil, thiamine, allantoin
Spa2297_RS26795	COG2027	D-alanyl-D-alanine carboxypeptidase
Spa2297_RS26805	COG4566	intracellular signal transduction
Spa2297_RS26830	COG0483	inositol monophosphate 1-phosphatase activity
Spa2297_RS26840	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Spa2297_RS26855	COG0601	transmembrane transport
Spa2297_RS26860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spa2297_RS26865	COG0444	Belongs to the ABC transporter superfamily
Spa2297_RS26870	COG1124	(ABC) transporter
Spa2297_RS26890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Spa2297_RS26900	COG1929	Belongs to the glycerate kinase type-1 family
Spa2297_RS26910	COG0688	phosphatidylethanolamine metabolic process
Spa2297_RS26915	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS26925	COG2301	Belongs to the HpcH HpaI aldolase family
Spa2297_RS26930	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS26930	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spa2297_RS26945	COG1250	3-hydroxyacyl-CoA dehydrogenase
Spa2297_RS26955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Spa2297_RS26955	COG0456	acetyltransferase
Spa2297_RS26965	COG0596	Alpha beta hydrolase
Spa2297_RS26985	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS26985	COG2172	sigma factor antagonist activity
Spa2297_RS26985	COG2208	phosphoserine phosphatase activity
Spa2297_RS26995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Spa2297_RS27000	COG2362	D-Aminopeptidase
Spa2297_RS27005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spa2297_RS27015	COG1619	proteins homologs of microcin C7 resistance protein MccF
Spa2297_RS27055	COG1793	dna ligase
Spa2297_RS27055	COG3285	dna ligase
Spa2297_RS27115	COG1597	lipid kinase activity
Spa2297_RS27135	COG0693	protein deglycase activity
Spa2297_RS27140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Spa2297_RS27140	COG0517	IMP dehydrogenase activity
Spa2297_RS27165	COG1191	sigma factor activity
Spa2297_RS27205	COG0531	amino acid
Spa2297_RS27225	COG1140	nitrate reductase beta subunit
Spa2297_RS27245	COG2154	pterin-4-alpha-carbinolamine dehydratase
Spa2297_RS27250	COG4106	trans-aconitate 2-methyltransferase activity
Spa2297_RS27250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Spa2297_RS27255	COG5297	Belongs to the glycosyl hydrolase family 6
Spa2297_RS27260	COG2226	methyltransferase
Spa2297_RS27265	COG0656	L-ascorbic acid biosynthetic process
Spa2297_RS27275	COG0477	Major facilitator Superfamily
Spa2297_RS27300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Spa2297_RS27315	COG3383	formate dehydrogenase (NAD+) activity
Spa2297_RS27320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Spa2297_RS27330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Spa2297_RS27345	COG1129	ABC transporter
Spa2297_RS27350	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spa2297_RS27360	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS27380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Spa2297_RS27415	COG2223	nitrite transmembrane transporter activity
Spa2297_RS27425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Spa2297_RS27435	COG0045	succinate-CoA ligase (ADP-forming) activity
Spa2297_RS27445	COG1012	belongs to the aldehyde dehydrogenase family
Spa2297_RS27480	COG3629	intracellular signal transduction
Spa2297_RS27480	COG3903	Transcriptional regulator
Spa2297_RS27495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Spa2297_RS27525	COG1940	carbohydrate kinase activity
Spa2297_RS27530	COG2182	Extracellular solute-binding protein
Spa2297_RS27535	COG1175	transmembrane transport
Spa2297_RS27540	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS27545	COG2723	6-phospho-beta-galactosidase activity
Spa2297_RS27565	COG0714	Associated with various cellular activities
Spa2297_RS27570	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Spa2297_RS27605	COG0747	negative chemotaxis
Spa2297_RS27635	COG0297	glycogen (starch) synthase activity
Spa2297_RS27650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Spa2297_RS27660	COG0477	Major facilitator Superfamily
Spa2297_RS27670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Spa2297_RS27675	COG1082	Xylose isomerase domain protein TIM barrel
Spa2297_RS27675	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Spa2297_RS27685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Spa2297_RS27690	COG0166	Belongs to the GPI family
Spa2297_RS27705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Spa2297_RS27710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Spa2297_RS27725	COG1486	melibiose metabolic process
Spa2297_RS27735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Spa2297_RS27780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spa2297_RS27785	COG3938	Belongs to the proline racemase family
Spa2297_RS27795	COG0515	serine threonine protein kinase
Spa2297_RS27805	COG1132	(ABC) transporter
Spa2297_RS27810	COG1132	(ABC) transporter
Spa2297_RS27815	COG2197	response regulator
Spa2297_RS27825	COG0477	Major facilitator Superfamily
Spa2297_RS27840	COG3511	phospholipase C
Spa2297_RS27870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Spa2297_RS27875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Spa2297_RS27880	COG3485	protocatechuate 3,4-dioxygenase
Spa2297_RS27885	COG3485	protocatechuate 3,4-dioxygenase
Spa2297_RS27905	COG1470	cell adhesion involved in biofilm formation
Spa2297_RS27915	COG1793	dna ligase
Spa2297_RS27965	COG1834	amidinotransferase
Spa2297_RS27970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Spa2297_RS27975	COG0488	(ABC) transporter
Spa2297_RS28005	COG1515	deoxyribonuclease V activity
Spa2297_RS28020	COG3268	Saccharopine dehydrogenase
Spa2297_RS28025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Spa2297_RS28030	COG0183	Belongs to the thiolase family
Spa2297_RS28035	COG1024	Enoyl-CoA hydratase
Spa2297_RS28035	COG1250	3-hydroxyacyl-CoA dehydrogenase
Spa2297_RS28045	COG1113	amino acid transport
Spa2297_RS28055	COG2936	dipeptidyl-peptidase activity
Spa2297_RS28065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Spa2297_RS28075	COG0488	(ABC) transporter
Spa2297_RS28080	COG2183	response to ionizing radiation
Spa2297_RS28100	COG1024	Enoyl-CoA hydratase
Spa2297_RS28110	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Spa2297_RS28150	COG1134	teichoic acid transport
Spa2297_RS28155	COG1562	ergosterol biosynthetic process
Spa2297_RS28165	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Spa2297_RS28175	COG1657	PFAM Prenyltransferase squalene oxidase
Spa2297_RS28190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Spa2297_RS28195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Spa2297_RS28215	COG2365	Tyrosine phosphatase family
Spa2297_RS28225	COG2755	lipolytic protein G-D-S-L family
Spa2297_RS28250	COG1228	amidohydrolase
Spa2297_RS28320	COG1063	alcohol dehydrogenase
Spa2297_RS28325	COG0156	8-amino-7-oxononanoate synthase activity
Spa2297_RS28330	COG0583	DNA-binding transcription factor activity
Spa2297_RS28370	COG0174	glutamine synthetase
Spa2297_RS28390	COG2267	carboxylic ester hydrolase activity
Spa2297_RS28395	COG0183	Belongs to the thiolase family
Spa2297_RS28400	COG0318	PFAM AMP-dependent synthetase and ligase
Spa2297_RS28435	COG1088	dTDP-glucose 4,6-dehydratase activity
Spa2297_RS28440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Spa2297_RS28455	COG2188	Transcriptional regulator
Spa2297_RS28460	COG3962	Belongs to the TPP enzyme family
Spa2297_RS28465	COG3718	enzyme involved in inositol metabolism
Spa2297_RS28475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spa2297_RS28500	COG2764	glyoxalase bleomycin resistance protein dioxygenase
Spa2297_RS28505	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS28515	COG1609	Transcriptional regulator
Spa2297_RS28520	COG3548	integral membrane protein
Spa2297_RS28535	COG0385	Bile acid
Spa2297_RS28560	COG0384	phenazine biosynthesis protein PhzF
Spa2297_RS28580	COG2197	response regulator
Spa2297_RS28590	COG1404	Belongs to the peptidase S8 family
Spa2297_RS28610	COG2838	Isocitrate dehydrogenase
Spa2297_RS28615	COG0668	transmembrane transport
Spa2297_RS28620	COG0531	amino acid
Spa2297_RS28630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Spa2297_RS28650	COG1132	(ABC) transporter
Spa2297_RS28660	COG0366	Alpha amylase catalytic
Spa2297_RS28665	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS28670	COG1175	transmembrane transport
Spa2297_RS28675	COG1653	transport
Spa2297_RS28700	COG1278	Cold shock
Spa2297_RS28710	COG1309	transcriptional regulator
Spa2297_RS28720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Spa2297_RS28725	COG1121	(ABC) transporter
Spa2297_RS28730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Spa2297_RS28740	COG0803	Belongs to the bacterial solute-binding protein 9 family
Spa2297_RS28755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Spa2297_RS28760	COG1595	DNA-templated transcription, initiation
Spa2297_RS28770	COG0789	Transcriptional regulator
Spa2297_RS28795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS28800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Spa2297_RS28810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Spa2297_RS28825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Spa2297_RS28845	COG0297	glycogen (starch) synthase activity
Spa2297_RS28850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Spa2297_RS28860	COG3537	Alpha-1,2-mannosidase
Spa2297_RS28890	COG1609	Transcriptional regulator
Spa2297_RS28900	COG1175	transmembrane transport
Spa2297_RS28905	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS28930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Spa2297_RS28955	COG0531	amino acid
Spa2297_RS29005	COG5001	Diguanylate cyclase
Spa2297_RS29010	COG0583	DNA-binding transcription factor activity
Spa2297_RS29020	COG1053	succinate dehydrogenase
Spa2297_RS29025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Spa2297_RS29050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Spa2297_RS29060	COG3360	Dodecin
Spa2297_RS29065	COG2182	Extracellular solute-binding protein
Spa2297_RS29070	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Spa2297_RS29075	COG0121	glutamine amidotransferase
Spa2297_RS29080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Spa2297_RS29085	COG3572	ergothioneine biosynthetic process
Spa2297_RS29100	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Spa2297_RS29105	COG3467	pyridoxamine 5'-phosphate
Spa2297_RS29125	COG0596	Alpha beta hydrolase
Spa2297_RS29130	COG3629	intracellular signal transduction
Spa2297_RS29130	COG3903	Transcriptional regulator
Spa2297_RS29145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spa2297_RS29165	COG1609	Transcriptional regulator
Spa2297_RS29170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spa2297_RS29180	COG0242	peptide deformylase activity
Spa2297_RS29200	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS29205	COG1366	Belongs to the anti-sigma-factor antagonist family
Spa2297_RS29210	COG2172	sigma factor antagonist activity
Spa2297_RS29220	COG5002	protein histidine kinase activity
Spa2297_RS29220	COG0784	Response regulator, receiver
Spa2297_RS29220	COG2198	Histidine kinase
Spa2297_RS29240	COG2072	flavoprotein involved in K transport
Spa2297_RS29245	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS29265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Spa2297_RS29270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Spa2297_RS29310	COG0500	methyltransferase
Spa2297_RS29315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Spa2297_RS29335	COG1902	pentaerythritol trinitrate reductase activity
Spa2297_RS29370	COG1349	DNA-binding transcription factor activity
Spa2297_RS29380	COG0494	nUDIX hydrolase
Spa2297_RS29390	COG2770	Histidine kinase
Spa2297_RS29390	COG2208	phosphoserine phosphatase activity
Spa2297_RS29435	COG4948	Mandelate Racemase Muconate Lactonizing
Spa2297_RS29440	COG0800	Aldolase
Spa2297_RS29490	COG0702	epimerase
Spa2297_RS29495	COG1846	Transcriptional regulator
Spa2297_RS29500	COG2409	Drug exporters of the RND superfamily
Spa2297_RS29515	COG0668	transmembrane transport
Spa2297_RS29555	COG3540	Alkaline phosphatase
Spa2297_RS29585	COG0542	response to heat
Spa2297_RS29595	COG0577	efflux transmembrane transporter activity
Spa2297_RS29595	COG1136	(ABC) transporter
Spa2297_RS29600	COG1174	glycine betaine transport
Spa2297_RS29605	COG1174	glycine betaine transport
Spa2297_RS29620	COG3250	beta-galactosidase activity
Spa2297_RS29625	COG1556	Lactate utilization protein
Spa2297_RS29630	COG1139	Iron-sulfur cluster binding protein
Spa2297_RS29635	COG0247	lactate metabolic process
Spa2297_RS29640	COG1070	Carbohydrate kinase
Spa2297_RS29645	COG3347	Dehydrogenase
Spa2297_RS29645	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS29650	COG4952	isomerase
Spa2297_RS29655	COG1129	ABC transporter
Spa2297_RS29660	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spa2297_RS29665	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spa2297_RS29670	COG1879	ABC-type sugar transport system periplasmic component
Spa2297_RS29680	COG1609	Transcriptional regulator
Spa2297_RS29695	COG1595	DNA-templated transcription, initiation
Spa2297_RS29700	COG1357	PFAM Pentapeptide repeats (8 copies)
Spa2297_RS29705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Spa2297_RS29705	COG2124	cytochrome p450
Spa2297_RS29710	COG1309	transcriptional regulator
Spa2297_RS29720	COG2706	6-phosphogluconolactonase activity
Spa2297_RS29760	COG1796	DNA polymerase
Spa2297_RS29760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Spa2297_RS29795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Spa2297_RS29835	COG2124	cytochrome p450
Spa2297_RS29850	COG0435	Glutathione S-transferase
Spa2297_RS29865	COG2124	cytochrome p450
Spa2297_RS29875	COG0667	Aldo Keto reductase
Spa2297_RS29900	COG1304	FMN binding
Spa2297_RS29915	COG2890	protein-(glutamine-N5) methyltransferase activity
Spa2297_RS29925	COG0248	Ppx GppA phosphatase
Spa2297_RS29985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Spa2297_RS30020	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS30030	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS30050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Spa2297_RS30115	COG2409	Drug exporters of the RND superfamily
Spa2297_RS30135	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS30150	COG2508	Transcriptional regulator
Spa2297_RS30155	COG0410	ABC transporter
Spa2297_RS30160	COG0411	ABC transporter
Spa2297_RS30240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Spa2297_RS30245	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Spa2297_RS30250	COG2080	2 iron, 2 sulfur cluster binding
Spa2297_RS30260	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS30265	COG1295	ribonuclease BN
Spa2297_RS30295	COG0477	Major facilitator Superfamily
Spa2297_RS30310	COG3290	protein histidine kinase activity
Spa2297_RS30345	COG0277	FAD linked oxidase domain protein
Spa2297_RS30360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Spa2297_RS30365	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS30370	COG1175	transmembrane transport
Spa2297_RS30435	COG2264	protein methyltransferase activity
Spa2297_RS30475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS30480	COG1120	ATPase activity
Spa2297_RS30510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Spa2297_RS30515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Spa2297_RS30530	COG1595	DNA-templated transcription, initiation
Spa2297_RS30545	COG1233	COG1233 Phytoene dehydrogenase and related
Spa2297_RS30580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Spa2297_RS30595	COG2235	arginine
Spa2297_RS30645	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Spa2297_RS30650	COG1191	sigma factor activity
Spa2297_RS30660	COG0783	Belongs to the Dps family
Spa2297_RS30665	COG0655	NAD(P)H dehydrogenase (quinone) activity
Spa2297_RS30705	COG2018	Roadblock/LC7 domain
Spa2297_RS30720	COG2124	cytochrome p450
Spa2297_RS30725	COG2124	cytochrome p450
Spa2297_RS30730	COG3340	Belongs to the peptidase S51 family
Spa2297_RS30745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Spa2297_RS30750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spa2297_RS30755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Spa2297_RS30760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Spa2297_RS30765	COG0142	geranyltranstransferase activity
Spa2297_RS30800	COG0789	Transcriptional regulator
Spa2297_RS30835	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS30840	COG2205	protein histidine kinase activity
Spa2297_RS30845	COG2340	Cysteine-rich secretory protein family
Spa2297_RS30855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Spa2297_RS30870	COG0667	Aldo Keto reductase
Spa2297_RS30880	COG2326	polyphosphate kinase activity
Spa2297_RS30890	COG1196	nuclear chromosome segregation
Spa2297_RS30890	COG0739	heme binding
Spa2297_RS30890	COG0741	lytic transglycosylase activity
Spa2297_RS30895	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS30900	COG1486	melibiose metabolic process
Spa2297_RS30905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spa2297_RS30910	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS30940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Spa2297_RS30945	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS30950	COG1175	transmembrane transport
Spa2297_RS30955	COG2182	Extracellular solute-binding protein
Spa2297_RS30960	COG2188	Transcriptional regulator
Spa2297_RS30965	COG0673	inositol 2-dehydrogenase activity
Spa2297_RS30985	COG1278	Cold shock
Spa2297_RS31005	COG0666	response to abiotic stimulus
Spa2297_RS31020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Spa2297_RS31030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Spa2297_RS31065	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Spa2297_RS31070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS31075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS31080	COG1120	ATPase activity
Spa2297_RS31085	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Spa2297_RS31090	COG1132	(ABC) transporter
Spa2297_RS31100	COG1132	(ABC) transporter
Spa2297_RS31110	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Spa2297_RS31115	COG2382	esterase
Spa2297_RS31145	COG0477	Major facilitator Superfamily
Spa2297_RS31165	COG0346	lactoylglutathione lyase activity
Spa2297_RS31170	COG0640	Transcriptional regulator
Spa2297_RS31205	COG1609	Transcriptional regulator
Spa2297_RS31210	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS31215	COG1175	transmembrane transport
Spa2297_RS31225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Spa2297_RS31230	COG2208	phosphoserine phosphatase activity
Spa2297_RS31240	COG0477	Major facilitator Superfamily
Spa2297_RS31275	COG1984	allophanate hydrolase subunit 2
Spa2297_RS31280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Spa2297_RS31285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Spa2297_RS31300	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Spa2297_RS31310	COG2267	carboxylic ester hydrolase activity
Spa2297_RS31315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Spa2297_RS31320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Spa2297_RS31320	COG1263	PTS System
Spa2297_RS31345	COG0596	Alpha beta hydrolase
Spa2297_RS31350	COG1191	sigma factor activity
Spa2297_RS31365	COG1309	transcriptional regulator
Spa2297_RS31370	COG0667	Aldo Keto reductase
Spa2297_RS31385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Spa2297_RS31400	COG1595	DNA-templated transcription, initiation
Spa2297_RS31420	COG1609	Transcriptional regulator
Spa2297_RS31445	COG1175	transmembrane transport
Spa2297_RS31450	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS31465	COG0460	homoserine dehydrogenase
Spa2297_RS31470	COG0604	alcohol dehydrogenase
Spa2297_RS31475	COG1733	regulation of RNA biosynthetic process
Spa2297_RS31500	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Spa2297_RS31505	COG0739	heme binding
Spa2297_RS31510	COG1024	Enoyl-CoA hydratase
Spa2297_RS31525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Spa2297_RS31530	COG0402	S-adenosylhomocysteine deaminase activity
Spa2297_RS31535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Spa2297_RS31550	COG1070	Carbohydrate kinase
Spa2297_RS31555	COG0277	FAD linked oxidase domain protein
Spa2297_RS31560	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS31570	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Spa2297_RS31575	COG2233	PERMEase
Spa2297_RS31580	COG0402	S-adenosylhomocysteine deaminase activity
Spa2297_RS31650	COG0745	RESPONSE REGULATOR receiver
Spa2297_RS31655	COG4251	negative regulation of phosphorylation
Spa2297_RS31660	COG0784	Response regulator, receiver
Spa2297_RS31665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS31670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Spa2297_RS31695	COG5640	endopeptidase activity
Spa2297_RS31715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Spa2297_RS31730	COG1215	transferase activity, transferring glycosyl groups
Spa2297_RS31740	COG4310	Domain of unknown function (DUF2172)
Spa2297_RS31755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Spa2297_RS31790	COG0367	asparagine synthase
Spa2297_RS31810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Spa2297_RS31815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Spa2297_RS31825	COG0148	phosphopyruvate hydratase activity
Spa2297_RS31835	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Spa2297_RS31840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Spa2297_RS31845	COG0028	Belongs to the TPP enzyme family
Spa2297_RS31850	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS31870	COG2770	Histidine kinase
Spa2297_RS31870	COG2208	phosphoserine phosphatase activity
Spa2297_RS31875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Spa2297_RS31875	COG0723	plastoquinol--plastocyanin reductase activity
Spa2297_RS31880	COG1891	lyase activity
Spa2297_RS31895	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Spa2297_RS31900	COG1960	acyl-CoA dehydrogenase activity
Spa2297_RS32045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Spa2297_RS32055	COG1609	Transcriptional regulator
Spa2297_RS32065	COG4948	Mandelate Racemase Muconate Lactonizing
Spa2297_RS32080	COG1028	Short-chain dehydrogenase reductase Sdr
Spa2297_RS32120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Spa2297_RS32130	COG0179	Fumarylacetoacetate (FAA) hydrolase
Spa2297_RS32140	COG1802	Transcriptional regulator
Spa2297_RS32180	COG1252	NADH dehydrogenase
Spa2297_RS32185	COG1595	DNA-templated transcription, initiation
Spa2297_RS32415	COG1879	ABC-type sugar transport system periplasmic component
Spa2297_RS32590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS32830	COG0667	Aldo Keto reductase
Spa2297_RS33040	COG0395	ABC-type sugar transport system, permease component
Spa2297_RS33245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spa2297_RS33535	COG0366	Alpha amylase catalytic
Spa2297_RS33780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Spa2297_RS33780	COG0515	serine threonine protein kinase
Spa2297_RS34285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity