locus-tag	class	description
NFX46_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NFX46_RS00010	COG0592	DNA-directed DNA polymerase activity
NFX46_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NFX46_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NFX46_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NFX46_RS00030	COG0187	DNA topoisomerase II activity
NFX46_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NFX46_RS00065	COG0515	serine threonine protein kinase
NFX46_RS00090	COG0457	Tetratricopeptide repeat
NFX46_RS00090	COG0705	Rhomboid family
NFX46_RS00105	COG3764	Sortase (surface protein transpeptidase)
NFX46_RS00120	COG3764	Sortase (surface protein transpeptidase)
NFX46_RS00125	COG3764	Sortase (surface protein transpeptidase)
NFX46_RS00130	COG0515	serine threonine protein kinase
NFX46_RS00135	COG0768	penicillin binding
NFX46_RS00150	COG1716	ATPase activity
NFX46_RS00155	COG1716	ATPase activity
NFX46_RS00185	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS00190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NFX46_RS00195	COG2151	metal-sulfur cluster biosynthetic enzyme
NFX46_RS00200	COG3396	Phenylacetate-CoA oxygenase
NFX46_RS00205	COG3460	Phenylacetate-CoA oxygenase
NFX46_RS00210	COG3396	Phenylacetate-CoA oxygenase
NFX46_RS00235	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFX46_RS00240	COG1309	transcriptional regulator
NFX46_RS00245	COG1522	sequence-specific DNA binding
NFX46_RS00265	COG0746	molybdenum cofactor guanylyltransferase activity
NFX46_RS00275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NFX46_RS00295	COG0604	alcohol dehydrogenase
NFX46_RS00295	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS00295	COG3321	synthase
NFX46_RS00310	COG0515	serine threonine protein kinase
NFX46_RS00315	COG0515	serine threonine protein kinase
NFX46_RS00320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NFX46_RS00330	COG0022	dehydrogenase e1 component
NFX46_RS00335	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFX46_RS00400	COG1362	aminopeptidase activity
NFX46_RS00405	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS00420	COG1741	Belongs to the pirin family
NFX46_RS00430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NFX46_RS00445	COG3866	Pectate lyase
NFX46_RS00500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NFX46_RS00515	COG1289	transmembrane transporter activity
NFX46_RS00575	COG0701	Predicted permease
NFX46_RS00600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NFX46_RS00605	COG1957	nucleoside hydrolase
NFX46_RS00620	COG0366	Alpha amylase catalytic
NFX46_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS00680	COG4977	sequence-specific DNA binding
NFX46_RS00730	COG1316	TRANSCRIPTIONal
NFX46_RS00820	COG0464	growth
NFX46_RS00900	COG0513	Belongs to the DEAD box helicase family
NFX46_RS00905	COG1278	Cold shock
NFX46_RS00910	COG2409	Drug exporters of the RND superfamily
NFX46_RS00915	COG4585	Histidine kinase
NFX46_RS00950	COG1595	DNA-templated transcription, initiation
NFX46_RS00960	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NFX46_RS00960	COG2508	Transcriptional regulator
NFX46_RS00965	COG0019	diaminopimelate decarboxylase activity
NFX46_RS00975	COG2205	protein histidine kinase activity
NFX46_RS00995	COG2267	carboxylic ester hydrolase activity
NFX46_RS01045	COG2188	Transcriptional regulator
NFX46_RS01055	COG2188	Transcriptional regulator
NFX46_RS01115	COG0717	Belongs to the dCTP deaminase family
NFX46_RS01120	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NFX46_RS01135	COG2181	nitrate reductase activity
NFX46_RS01135	COG0247	lactate metabolic process
NFX46_RS01140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NFX46_RS01145	COG0443	Heat shock 70 kDa protein
NFX46_RS01150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NFX46_RS01155	COG0484	heat shock protein binding
NFX46_RS01160	COG0789	Transcriptional regulator
NFX46_RS01165	COG4213	ABC transporter substrate-binding protein
NFX46_RS01200	COG0542	response to heat
NFX46_RS01225	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NFX46_RS01240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NFX46_RS01245	COG0191	fructose-bisphosphate aldolase activity
NFX46_RS01260	COG3483	tryptophan 2,3-dioxygenase activity
NFX46_RS01265	COG3844	kynureninase activity
NFX46_RS01290	COG4585	Histidine kinase
NFX46_RS01300	COG4585	Histidine kinase
NFX46_RS01305	COG2197	response regulator
NFX46_RS01310	COG2124	cytochrome p450
NFX46_RS01315	COG3559	Exporter of polyketide antibiotics
NFX46_RS01320	COG1131	(ABC) transporter
NFX46_RS01335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NFX46_RS01350	COG0463	Glycosyl transferase, family 2
NFX46_RS01355	COG1802	Transcriptional regulator
NFX46_RS01360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NFX46_RS01365	COG0693	protein deglycase activity
NFX46_RS01385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NFX46_RS01390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NFX46_RS01410	COG2205	protein histidine kinase activity
NFX46_RS01430	COG1595	DNA-templated transcription, initiation
NFX46_RS01455	COG0701	Predicted permease
NFX46_RS01515	COG1201	RNA secondary structure unwinding
NFX46_RS01545	COG0494	nUDIX hydrolase
NFX46_RS01560	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
NFX46_RS01575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NFX46_RS01710	COG1408	metallophosphoesterase
NFX46_RS01720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NFX46_RS01730	COG0003	Pfam Anion-transporting ATPase
NFX46_RS01745	COG0251	oxidation-reduction process
NFX46_RS01755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NFX46_RS01790	COG2267	carboxylic ester hydrolase activity
NFX46_RS01805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NFX46_RS01810	COG0288	reversible hydration of carbon dioxide
NFX46_RS02115	COG1111	helicase
NFX46_RS02115	COG1205	dead DEAH box helicase
NFX46_RS02120	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS02130	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NFX46_RS02150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NFX46_RS02150	COG1754	DNA topoisomerase type I activity
NFX46_RS02155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NFX46_RS02160	COG0470	DNA polymerase III
NFX46_RS02205	COG2197	response regulator
NFX46_RS02215	COG2197	response regulator
NFX46_RS02220	COG4585	Histidine kinase
NFX46_RS02225	COG1136	(ABC) transporter
NFX46_RS02225	COG0577	efflux transmembrane transporter activity
NFX46_RS02240	COG3903	Transcriptional regulator
NFX46_RS02240	COG3629	intracellular signal transduction
NFX46_RS02245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NFX46_RS02245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NFX46_RS02270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NFX46_RS02275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NFX46_RS02280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NFX46_RS02285	COG0254	rRNA binding
NFX46_RS02295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NFX46_RS02315	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS02335	COG0076	glutamate decarboxylase activity
NFX46_RS02345	COG0789	Transcriptional regulator
NFX46_RS02350	COG0393	Putative heavy-metal-binding
NFX46_RS02365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NFX46_RS02370	COG2027	D-alanyl-D-alanine carboxypeptidase
NFX46_RS02380	COG0037	tRNA processing
NFX46_RS02395	COG0302	gtp cyclohydrolase
NFX46_RS02410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NFX46_RS02450	COG0649	NAD binding
NFX46_RS02465	COG2197	response regulator
NFX46_RS02470	COG1660	Displays ATPase and GTPase activities
NFX46_RS02480	COG0640	Transcriptional regulator
NFX46_RS02495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NFX46_RS02500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NFX46_RS02510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NFX46_RS02530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NFX46_RS02555	COG0739	heme binding
NFX46_RS02570	COG2205	protein histidine kinase activity
NFX46_RS02575	COG0745	RESPONSE REGULATOR receiver
NFX46_RS02585	COG1595	DNA-templated transcription, initiation
NFX46_RS02590	COG1194	a g-specific adenine glycosylase
NFX46_RS02600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NFX46_RS02620	COG0248	Ppx GppA phosphatase
NFX46_RS02625	COG1082	Xylose isomerase domain protein TIM barrel
NFX46_RS02635	COG0129	dihydroxy-acid dehydratase activity
NFX46_RS02645	COG4991	sh3 domain protein
NFX46_RS02665	COG0842	Transport permease protein
NFX46_RS02665	COG1129	ABC transporter
NFX46_RS02675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NFX46_RS02680	COG1335	isochorismatase
NFX46_RS02690	COG0180	Tryptophanyl-tRNA synthetase
NFX46_RS02715	COG0738	Major facilitator superfamily
NFX46_RS02720	COG0123	including yeast histone deacetylase and acetoin utilization protein
NFX46_RS02770	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NFX46_RS02775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NFX46_RS02780	COG0181	hydroxymethylbilane synthase activity
NFX46_RS02785	COG1648	precorrin-2 dehydrogenase activity
NFX46_RS02785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NFX46_RS02790	COG0113	porphobilinogen synthase activity
NFX46_RS02805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFX46_RS02830	COG0018	arginyl-trna synthetase
NFX46_RS02835	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NFX46_RS02855	COG1690	Belongs to the RtcB family
NFX46_RS02875	COG1742	UPF0060 membrane protein
NFX46_RS02880	COG1846	Transcriptional regulator
NFX46_RS02885	COG0701	Predicted permease
NFX46_RS02900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS02920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NFX46_RS02930	COG0640	Transcriptional regulator
NFX46_RS02945	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NFX46_RS02955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NFX46_RS02960	COG0406	alpha-ribazole phosphatase activity
NFX46_RS02970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NFX46_RS02975	COG0785	Cytochrome C biogenesis protein
NFX46_RS02980	COG1333	cytochrome c biogenesis protein
NFX46_RS02985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NFX46_RS03005	COG0789	Transcriptional regulator
NFX46_RS03015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NFX46_RS03020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NFX46_RS03025	COG0163	prenyltransferase activity
NFX46_RS03035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NFX46_RS03050	COG1309	transcriptional regulator
NFX46_RS03085	COG2226	methyltransferase
NFX46_RS03110	COG1278	Cold shock
NFX46_RS03115	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NFX46_RS03130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NFX46_RS03160	COG2226	methyltransferase
NFX46_RS03185	COG0791	NLP P60 protein
NFX46_RS03195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03205	COG0649	NAD binding
NFX46_RS03215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NFX46_RS03220	COG1034	ATP synthesis coupled electron transport
NFX46_RS03225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NFX46_RS03230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03235	COG0839	Belongs to the complex I subunit 6 family
NFX46_RS03240	COG0713	ATP synthesis coupled electron transport
NFX46_RS03245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NFX46_RS03255	COG1007	ATP synthesis coupled electron transport
NFX46_RS03300	COG0726	polysaccharide deacetylase
NFX46_RS03320	COG3953	SLT domain
NFX46_RS03320	COG5412	phage tail tape measure protein
NFX46_RS03330	COG0142	geranyltranstransferase activity
NFX46_RS03355	COG0154	amidase activity
NFX46_RS03370	COG4935	Belongs to the peptidase S8 family
NFX46_RS03370	COG2234	aminopeptidase activity
NFX46_RS03395	COG0702	epimerase
NFX46_RS03400	COG1013	pyruvate-flavodoxin oxidoreductase activity
NFX46_RS03405	COG0674	pyruvate-flavodoxin oxidoreductase activity
NFX46_RS03405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NFX46_RS03425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NFX46_RS03445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03455	COG0713	ATP synthesis coupled electron transport
NFX46_RS03460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NFX46_RS03465	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NFX46_RS03470	COG1007	ATP synthesis coupled electron transport
NFX46_RS03475	COG0501	Belongs to the peptidase M48B family
NFX46_RS03480	COG3304	Inner membrane component domain
NFX46_RS03490	COG2261	transglycosylase associated protein
NFX46_RS03495	COG1666	GTP binding
NFX46_RS03540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NFX46_RS03545	COG2030	dehydratase
NFX46_RS03555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NFX46_RS03590	COG0515	serine threonine protein kinase
NFX46_RS03600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NFX46_RS03630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFX46_RS03635	COG0436	Aminotransferase
NFX46_RS03650	COG0250	Participates in transcription elongation, termination and antitermination
NFX46_RS03655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NFX46_RS03660	COG0081	regulation of translation
NFX46_RS03675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NFX46_RS03680	COG0222	ribosome binding
NFX46_RS03685	COG0085	RNA polymerase activity
NFX46_RS03690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NFX46_RS03705	COG0463	Glycosyl transferase, family 2
NFX46_RS03710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NFX46_RS03715	COG0049	tRNA binding
NFX46_RS03720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NFX46_RS03725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NFX46_RS03780	COG0051	transcription antitermination factor activity, RNA binding
NFX46_RS03785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NFX46_RS03790	COG0088	Forms part of the polypeptide exit tunnel
NFX46_RS03795	COG0089	rRNA binding
NFX46_RS03800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NFX46_RS03805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NFX46_RS03810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NFX46_RS03815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NFX46_RS03820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NFX46_RS03825	COG0255	Belongs to the universal ribosomal protein uL29 family
NFX46_RS03830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NFX46_RS03835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NFX46_RS03840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NFX46_RS03845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NFX46_RS03850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NFX46_RS03855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NFX46_RS03860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NFX46_RS03865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NFX46_RS03870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NFX46_RS03875	COG1841	ribosomal large subunit assembly
NFX46_RS03880	COG0200	Binds to the 23S rRNA
NFX46_RS03885	COG0201	protein transport
NFX46_RS03890	COG0563	adenylate kinase activity
NFX46_RS03900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NFX46_RS03905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NFX46_RS03910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NFX46_RS03915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NFX46_RS03920	COG0202	RNA polymerase activity
NFX46_RS03925	COG0203	ribosomal protein L17
NFX46_RS03930	COG0101	tRNA pseudouridine synthase activity
NFX46_RS03945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NFX46_RS03950	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NFX46_RS03955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NFX46_RS03965	COG1072	(Pantothenic acid kinase))
NFX46_RS03975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NFX46_RS03990	COG0736	holo-[acyl-carrier-protein] synthase activity
NFX46_RS04000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NFX46_RS04010	COG0802	atpase or kinase
NFX46_RS04035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NFX46_RS04050	COG1609	Transcriptional regulator
NFX46_RS04060	COG1316	TRANSCRIPTIONal
NFX46_RS04070	COG4941	Belongs to the sigma-70 factor family
NFX46_RS04080	COG0726	polysaccharide deacetylase
NFX46_RS04085	COG0726	polysaccharide deacetylase
NFX46_RS04090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NFX46_RS04095	COG0459	protein refolding
NFX46_RS04105	COG4221	oxidoreductase activity
NFX46_RS04115	COG0583	DNA-binding transcription factor activity
NFX46_RS04130	COG1595	DNA-templated transcription, initiation
NFX46_RS04140	COG0516	GMP reductase activity
NFX46_RS04150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NFX46_RS04165	COG2815	serine threonine protein kinase
NFX46_RS04165	COG0515	serine threonine protein kinase
NFX46_RS04170	COG0515	serine threonine protein kinase
NFX46_RS04175	COG0515	serine threonine protein kinase
NFX46_RS04180	COG0515	serine threonine protein kinase
NFX46_RS04185	COG2815	serine threonine protein kinase
NFX46_RS04185	COG0515	serine threonine protein kinase
NFX46_RS04190	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS04215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NFX46_RS04215	COG0519	Catalyzes the synthesis of GMP from XMP
NFX46_RS04255	COG2197	response regulator
NFX46_RS04290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS04290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS04305	COG0714	Associated with various cellular activities
NFX46_RS04315	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NFX46_RS04335	COG0045	succinate-CoA ligase (ADP-forming) activity
NFX46_RS04365	COG0138	bifunctional purine biosynthesis protein purh
NFX46_RS04370	COG0515	serine threonine protein kinase
NFX46_RS04370	COG2815	serine threonine protein kinase
NFX46_RS04385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NFX46_RS04400	COG0039	L-malate dehydrogenase activity
NFX46_RS04405	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS04415	COG4175	Glycine betaine
NFX46_RS04415	COG0517	IMP dehydrogenase activity
NFX46_RS04420	COG4176	ABC-type proline glycine betaine transport system permease component
NFX46_RS04430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NFX46_RS04435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NFX46_RS04440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFX46_RS04445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NFX46_RS04450	COG0180	Tryptophanyl-tRNA synthetase
NFX46_RS04470	COG0671	phosphoesterase, PA-phosphatase related
NFX46_RS04480	COG1295	ribonuclease BN
NFX46_RS04485	COG1686	Belongs to the peptidase S11 family
NFX46_RS04495	COG1408	metallophosphoesterase
NFX46_RS04500	COG2205	protein histidine kinase activity
NFX46_RS04505	COG0745	RESPONSE REGULATOR receiver
NFX46_RS04510	COG2409	Drug exporters of the RND superfamily
NFX46_RS04515	COG1309	transcriptional regulator
NFX46_RS04555	COG1053	succinate dehydrogenase
NFX46_RS04565	COG2009	succinate dehydrogenase
NFX46_RS04575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NFX46_RS04605	COG1595	DNA-templated transcription, initiation
NFX46_RS04620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS04620	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS04625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NFX46_RS04640	COG1216	Glycosyl transferase, family 2
NFX46_RS04655	COG2089	acid synthase
NFX46_RS04665	COG2226	methyltransferase
NFX46_RS04670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NFX46_RS04670	COG1473	amidohydrolase
NFX46_RS04675	COG1744	ABC transporter substrate-binding protein PnrA-like
NFX46_RS04680	COG1744	ABC transporter substrate-binding protein PnrA-like
NFX46_RS04685	COG3845	ABC transporter
NFX46_RS04695	COG1079	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS04730	COG2814	Major facilitator Superfamily
NFX46_RS04735	COG0583	DNA-binding transcription factor activity
NFX46_RS04745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFX46_RS04770	COG2205	protein histidine kinase activity
NFX46_RS04775	COG0745	RESPONSE REGULATOR receiver
NFX46_RS04785	COG1595	DNA-templated transcription, initiation
NFX46_RS04800	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS04805	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS04810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NFX46_RS04820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NFX46_RS04845	COG4770	biotin carboxylase activity
NFX46_RS04855	COG0424	maF-like protein
NFX46_RS04870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NFX46_RS04880	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NFX46_RS04890	COG1024	Enoyl-CoA hydratase
NFX46_RS04900	COG2986	histidine ammonia-lyase
NFX46_RS04930	COG1136	(ABC) transporter
NFX46_RS04940	COG1064	alcohol dehydrogenase
NFX46_RS04960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFX46_RS04970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NFX46_RS04995	COG2255	four-way junction helicase activity
NFX46_RS05000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NFX46_RS05015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NFX46_RS05025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NFX46_RS05040	COG1331	Highly conserved protein containing a thioredoxin domain
NFX46_RS05045	COG0463	Glycosyl transferase, family 2
NFX46_RS05070	COG1309	transcriptional regulator
NFX46_RS05080	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NFX46_RS05115	COG0436	Aminotransferase
NFX46_RS05130	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NFX46_RS05145	COG1414	Transcriptional regulator
NFX46_RS05150	COG0251	oxidation-reduction process
NFX46_RS05155	COG2610	gluconate transmembrane transporter activity
NFX46_RS05190	COG1335	isochorismatase
NFX46_RS05255	COG2894	cell division
NFX46_RS05290	COG2197	response regulator
NFX46_RS05360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NFX46_RS05365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NFX46_RS05385	COG1136	(ABC) transporter
NFX46_RS05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NFX46_RS05420	COG0114	fumarate hydratase activity
NFX46_RS05425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NFX46_RS05425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NFX46_RS05450	COG0778	Nitroreductase
NFX46_RS05455	COG1722	exodeoxyribonuclease VII activity
NFX46_RS05460	COG1570	exodeoxyribonuclease VII activity
NFX46_RS05465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NFX46_RS05480	COG0012	GTP binding
NFX46_RS05550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NFX46_RS05555	COG1053	succinate dehydrogenase
NFX46_RS05575	COG1217	gtp-binding protein TYPA
NFX46_RS05580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFX46_RS05585	COG4166	transmembrane transport
NFX46_RS05595	COG0444	Belongs to the ABC transporter superfamily
NFX46_RS05600	COG4608	Belongs to the ABC transporter superfamily
NFX46_RS05610	COG0601	transmembrane transport
NFX46_RS05615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFX46_RS05625	COG4608	Belongs to the ABC transporter superfamily
NFX46_RS05640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NFX46_RS05685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NFX46_RS05690	COG1611	Belongs to the LOG family
NFX46_RS05695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NFX46_RS05705	COG0519	Catalyzes the synthesis of GMP from XMP
NFX46_RS05710	COG1024	Enoyl-CoA hydratase
NFX46_RS05725	COG1595	DNA-templated transcription, initiation
NFX46_RS05735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NFX46_RS05740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NFX46_RS05775	COG0598	Magnesium transport protein CorA
NFX46_RS05785	COG2814	Major facilitator Superfamily
NFX46_RS05800	COG2095	MarC family integral membrane protein
NFX46_RS05810	COG1432	Conserved Protein
NFX46_RS05870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFX46_RS05910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NFX46_RS05945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NFX46_RS06000	COG3480	Lon protease (S16) C-terminal proteolytic domain
NFX46_RS06010	COG1615	UPF0182 protein
NFX46_RS06035	COG0753	catalase activity
NFX46_RS06045	COG0483	inositol monophosphate 1-phosphatase activity
NFX46_RS06055	COG2076	Multidrug Resistance protein
NFX46_RS06065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NFX46_RS06075	COG2135	peptidase activity
NFX46_RS06085	COG1595	DNA-templated transcription, initiation
NFX46_RS06090	COG5662	AntiSigma factor
NFX46_RS06095	COG2199	diguanylate cyclase activity
NFX46_RS06095	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NFX46_RS06110	COG0242	peptide deformylase activity
NFX46_RS06120	COG2124	cytochrome p450
NFX46_RS06125	COG4977	sequence-specific DNA binding
NFX46_RS06150	COG2188	Transcriptional regulator
NFX46_RS06155	COG2182	Extracellular solute-binding protein
NFX46_RS06160	COG1175	transmembrane transport
NFX46_RS06165	COG0395	ABC-type sugar transport system, permease component
NFX46_RS06170	COG1472	Belongs to the glycosyl hydrolase 3 family
NFX46_RS06175	COG0363	glucosamine-6-phosphate deaminase activity
NFX46_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS06200	COG1597	lipid kinase activity
NFX46_RS06230	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NFX46_RS06235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NFX46_RS06240	COG0142	geranyltranstransferase activity
NFX46_RS06285	COG4106	trans-aconitate 2-methyltransferase activity
NFX46_RS06290	COG1126	abc transporter atp-binding protein
NFX46_RS06295	COG0765	amino acid transport
NFX46_RS06305	COG0281	malic enzyme
NFX46_RS06310	COG0604	alcohol dehydrogenase
NFX46_RS06340	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFX46_RS06340	COG0567	Dehydrogenase, E1 component
NFX46_RS06345	COG2205	protein histidine kinase activity
NFX46_RS06350	COG0745	RESPONSE REGULATOR receiver
NFX46_RS06370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NFX46_RS06385	COG5002	protein histidine kinase activity
NFX46_RS06410	COG0791	NLP P60 protein
NFX46_RS06410	COG3883	PFAM NLP P60 protein
NFX46_RS06460	COG2205	protein histidine kinase activity
NFX46_RS06480	COG1793	dna ligase
NFX46_RS06480	COG3285	dna ligase
NFX46_RS06485	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NFX46_RS06505	COG1609	Transcriptional regulator
NFX46_RS06630	COG0018	arginyl-trna synthetase
NFX46_RS06630	COG0018	arginyl-trna synthetase
NFX46_RS06635	COG0019	diaminopimelate decarboxylase activity
NFX46_RS06640	COG0460	homoserine dehydrogenase
NFX46_RS06645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NFX46_RS06650	COG0083	homoserine kinase activity
NFX46_RS06670	COG0254	rRNA binding
NFX46_RS06675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NFX46_RS06680	COG2890	protein-(glutamine-N5) methyltransferase activity
NFX46_RS06690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NFX46_RS06695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NFX46_RS06715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NFX46_RS06720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NFX46_RS06725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NFX46_RS06730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NFX46_RS06735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NFX46_RS06740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NFX46_RS06745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NFX46_RS06760	COG2197	response regulator
NFX46_RS06790	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NFX46_RS06825	COG1131	(ABC) transporter
NFX46_RS06845	COG0183	Belongs to the thiolase family
NFX46_RS06870	COG2205	protein histidine kinase activity
NFX46_RS06925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS06925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS06960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NFX46_RS06965	COG0280	phosphate acetyltransferase
NFX46_RS06965	COG0857	belongs to the CobB CobQ family
NFX46_RS06970	COG0205	6-phosphofructokinase activity
NFX46_RS06980	COG4565	transcriptional regulatory protein
NFX46_RS06985	COG3290	protein histidine kinase activity
NFX46_RS06990	COG1301	dicarboxylic acid transport
NFX46_RS07000	COG0477	Major facilitator Superfamily
NFX46_RS07015	COG1522	sequence-specific DNA binding
NFX46_RS07025	COG3118	belongs to the thioredoxin family
NFX46_RS07025	COG0492	ferredoxin-NADP+ reductase activity
NFX46_RS07035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NFX46_RS07040	COG3281	Trehalose synthase
NFX46_RS07045	COG0366	Alpha amylase catalytic
NFX46_RS07050	COG0366	Alpha amylase catalytic
NFX46_RS07060	COG0058	SHG alpha-glucan phosphorylase activity
NFX46_RS07120	COG1131	(ABC) transporter
NFX46_RS07150	COG1132	(ABC) transporter
NFX46_RS07160	COG1132	(ABC) transporter
NFX46_RS07165	COG1132	(ABC) transporter
NFX46_RS07170	COG1132	(ABC) transporter
NFX46_RS07185	COG1376	ErfK ybiS ycfS ynhG family protein
NFX46_RS07210	COG0789	Transcriptional regulator
NFX46_RS07220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NFX46_RS07225	COG3409	Peptidoglycan-binding domain 1 protein
NFX46_RS07225	COG3757	hydrolase, family 25
NFX46_RS07230	COG1760	l-serine dehydratase
NFX46_RS07235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NFX46_RS07240	COG0509	glycine decarboxylation via glycine cleavage system
NFX46_RS07245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NFX46_RS07265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFX46_RS07280	COG0444	Belongs to the ABC transporter superfamily
NFX46_RS07285	COG4608	Belongs to the ABC transporter superfamily
NFX46_RS07290	COG2860	membrane
NFX46_RS07300	COG1309	transcriptional regulator
NFX46_RS07320	COG3023	N-Acetylmuramoyl-L-alanine amidase
NFX46_RS07325	COG0482	sulfurtransferase activity
NFX46_RS07345	COG4221	oxidoreductase activity
NFX46_RS07355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NFX46_RS07375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NFX46_RS07380	COG0154	amidase activity
NFX46_RS07390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NFX46_RS07400	COG2409	Drug exporters of the RND superfamily
NFX46_RS07405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NFX46_RS07420	COG1672	PFAM Archaeal ATPase
NFX46_RS07420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NFX46_RS07435	COG0667	Aldo Keto reductase
NFX46_RS07440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NFX46_RS07445	COG5001	Diguanylate cyclase
NFX46_RS07455	COG0440	acetolactate synthase activity
NFX46_RS07460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NFX46_RS07465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NFX46_RS07470	COG0477	Major facilitator Superfamily
NFX46_RS07480	COG4608	Belongs to the ABC transporter superfamily
NFX46_RS07490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFX46_RS07495	COG0747	negative chemotaxis
NFX46_RS07500	COG3835	regulator
NFX46_RS07505	COG0506	proline dehydrogenase activity
NFX46_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS07520	COG0473	3-isopropylmalate dehydrogenase activity
NFX46_RS07525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NFX46_RS07535	COG0804	urea catabolic process
NFX46_RS07540	COG2957	Belongs to the agmatine deiminase family
NFX46_RS07550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NFX46_RS07575	COG2353	YceI-like domain
NFX46_RS07580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NFX46_RS07600	COG2018	Roadblock/LC7 domain
NFX46_RS07620	COG2018	Roadblock/LC7 domain
NFX46_RS07625	COG5002	protein histidine kinase activity
NFX46_RS07635	COG0179	Fumarylacetoacetate (FAA) hydrolase
NFX46_RS07640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NFX46_RS07685	COG1414	Transcriptional regulator
NFX46_RS07690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NFX46_RS07695	COG0066	3-isopropylmalate dehydratase activity
NFX46_RS07705	COG0776	regulation of translation
NFX46_RS07715	COG1920	GTP binding
NFX46_RS07725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NFX46_RS07730	COG1181	Belongs to the D-alanine--D-alanine ligase family
NFX46_RS07750	COG0351	phosphomethylpyrimidine kinase
NFX46_RS07755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NFX46_RS07760	COG1461	Dihydroxyacetone kinase
NFX46_RS07770	COG0326	Molecular chaperone. Has ATPase activity
NFX46_RS07780	COG0742	ribosomal rna small subunit methyltransferase
NFX46_RS07785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NFX46_RS07800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NFX46_RS07805	COG0571	ribonuclease III activity
NFX46_RS07810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NFX46_RS07815	COG1733	regulation of RNA biosynthetic process
NFX46_RS07870	COG2340	Cysteine-rich secretory protein family
NFX46_RS07875	COG1254	Belongs to the acylphosphatase family
NFX46_RS07890	COG0477	Major facilitator Superfamily
NFX46_RS07925	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NFX46_RS07935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NFX46_RS07945	COG0442	prolyl-tRNA aminoacylation
NFX46_RS07955	COG0228	four-way junction DNA binding
NFX46_RS07960	COG1837	Belongs to the UPF0109 family
NFX46_RS07965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NFX46_RS07970	COG0336	Belongs to the RNA methyltransferase TrmD family
NFX46_RS07975	COG0335	large ribosomal subunit rRNA binding
NFX46_RS08010	COG0792	nuclease activity
NFX46_RS08025	COG1191	sigma factor activity
NFX46_RS08040	COG0052	Belongs to the universal ribosomal protein uS2 family
NFX46_RS08045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NFX46_RS08050	COG0528	UMP kinase activity
NFX46_RS08055	COG0233	cytoplasmic translational termination
NFX46_RS08060	COG0575	Belongs to the CDS family
NFX46_RS08065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NFX46_RS08075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NFX46_RS08080	COG3842	ATPase activity
NFX46_RS08110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NFX46_RS08120	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS08165	COG1733	regulation of RNA biosynthetic process
NFX46_RS08190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFX46_RS08215	COG3842	ATPase activity
NFX46_RS08220	COG1176	ABC-type spermidine putrescine transport system, permease component I
NFX46_RS08225	COG1177	transmembrane transport
NFX46_RS08230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFX46_RS08240	COG2508	Transcriptional regulator
NFX46_RS08270	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS08280	COG1653	transport
NFX46_RS08285	COG4209	transmembrane transport
NFX46_RS08290	COG0395	ABC-type sugar transport system, permease component
NFX46_RS08330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NFX46_RS08335	COG0750	zinc metalloprotease
NFX46_RS08340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NFX46_RS08355	COG0442	prolyl-tRNA aminoacylation
NFX46_RS08380	COG0779	Required for maturation of 30S ribosomal subunits
NFX46_RS08395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NFX46_RS08405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NFX46_RS08410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NFX46_RS08425	COG0455	bacterial-type flagellum organization
NFX46_RS08440	COG3266	domain, Protein
NFX46_RS08445	COG1404	Belongs to the peptidase S8 family
NFX46_RS08460	COG1404	Belongs to the peptidase S8 family
NFX46_RS08490	COG1674	ftsk spoiiie
NFX46_RS08510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NFX46_RS08515	COG1185	polyribonucleotide nucleotidyltransferase activity
NFX46_RS08520	COG0612	Peptidase, M16
NFX46_RS08525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NFX46_RS08545	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NFX46_RS08550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NFX46_RS08555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NFX46_RS08585	COG2208	phosphoserine phosphatase activity
NFX46_RS08585	COG2770	Histidine kinase
NFX46_RS08590	COG3437	response regulator, receiver
NFX46_RS08590	COG2205	protein histidine kinase activity
NFX46_RS08590	COG4999	Histidine kinase
NFX46_RS08590	COG3850	Histidine kinase
NFX46_RS08600	COG1674	ftsk spoiiie
NFX46_RS08610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NFX46_RS08620	COG1546	Belongs to the CinA family
NFX46_RS08620	COG1058	Belongs to the CinA family
NFX46_RS08625	COG1396	sequence-specific DNA binding
NFX46_RS08630	COG0783	Belongs to the Dps family
NFX46_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS08645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NFX46_RS08650	COG1201	RNA secondary structure unwinding
NFX46_RS08655	COG2207	Transcriptional regulator
NFX46_RS08655	COG1917	Cupin 2, conserved barrel domain protein
NFX46_RS08705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NFX46_RS08720	COG0765	amino acid transport
NFX46_RS08725	COG0765	amino acid transport
NFX46_RS08730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFX46_RS08735	COG1126	abc transporter atp-binding protein
NFX46_RS08740	COG0745	RESPONSE REGULATOR receiver
NFX46_RS08745	COG2205	protein histidine kinase activity
NFX46_RS08775	COG2197	response regulator
NFX46_RS08795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NFX46_RS08815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NFX46_RS08825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NFX46_RS08830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NFX46_RS08840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NFX46_RS08865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NFX46_RS08870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NFX46_RS08875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NFX46_RS08895	COG0588	phosphoglycerate mutase activity
NFX46_RS08915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NFX46_RS08955	COG2186	Transcriptional regulator
NFX46_RS08960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NFX46_RS08975	COG0187	DNA topoisomerase II activity
NFX46_RS08990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFX46_RS08995	COG4565	transcriptional regulatory protein
NFX46_RS09000	COG3290	protein histidine kinase activity
NFX46_RS09015	COG0372	Belongs to the citrate synthase family
NFX46_RS09030	COG0523	cobalamin synthesis protein
NFX46_RS09035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NFX46_RS09040	COG0612	Peptidase, M16
NFX46_RS09055	COG1802	Transcriptional regulator
NFX46_RS09060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NFX46_RS09080	COG1435	thymidine kinase activity
NFX46_RS09115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NFX46_RS09130	COG0745	RESPONSE REGULATOR receiver
NFX46_RS09135	COG2205	protein histidine kinase activity
NFX46_RS09160	COG0756	dUTP diphosphatase activity
NFX46_RS09200	COG0569	domain protein
NFX46_RS09205	COG0531	amino acid
NFX46_RS09210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NFX46_RS09215	COG1302	Protein conserved in bacteria
NFX46_RS09265	COG0604	alcohol dehydrogenase
NFX46_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS09265	COG3321	synthase
NFX46_RS09295	COG1309	transcriptional regulator
NFX46_RS09360	COG2353	YceI-like domain
NFX46_RS09365	COG1799	cell septum assembly
NFX46_RS09395	COG2890	protein-(glutamine-N5) methyltransferase activity
NFX46_RS09400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NFX46_RS09415	COG2235	arginine
NFX46_RS09420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NFX46_RS09430	COG1024	Enoyl-CoA hydratase
NFX46_RS09470	COG0697	spore germination
NFX46_RS09490	COG3629	intracellular signal transduction
NFX46_RS09495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NFX46_RS09505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NFX46_RS09530	COG3655	Transcriptional regulator
NFX46_RS09545	COG1653	transport
NFX46_RS09550	COG1175	transmembrane transport
NFX46_RS09555	COG0395	ABC-type sugar transport system, permease component
NFX46_RS09560	COG1940	carbohydrate kinase activity
NFX46_RS09565	COG4213	ABC transporter substrate-binding protein
NFX46_RS09575	COG4214	carbohydrate transport
NFX46_RS09580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NFX46_RS09585	COG0531	amino acid
NFX46_RS09600	COG1024	Enoyl-CoA hydratase
NFX46_RS09600	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFX46_RS09605	COG0183	Belongs to the thiolase family
NFX46_RS09610	COG1609	Transcriptional regulator
NFX46_RS09615	COG3250	beta-galactosidase activity
NFX46_RS09650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NFX46_RS09665	COG0446	pyridine nucleotide-disulphide oxidoreductase
NFX46_RS09680	COG3253	May function as heme-dependent peroxidase
NFX46_RS09700	COG3220	belongs to the UPF0276 family
NFX46_RS09740	COG0330	HflC and HflK could
NFX46_RS09775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NFX46_RS09780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NFX46_RS09790	COG2205	protein histidine kinase activity
NFX46_RS09795	COG0745	RESPONSE REGULATOR receiver
NFX46_RS09825	COG1174	glycine betaine transport
NFX46_RS09850	COG2018	Roadblock/LC7 domain
NFX46_RS09855	COG5002	protein histidine kinase activity
NFX46_RS09890	COG1404	Belongs to the peptidase S8 family
NFX46_RS09920	COG0504	CTP synthase activity
NFX46_RS09935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NFX46_RS10015	COG1175	transmembrane transport
NFX46_RS10035	COG2409	Drug exporters of the RND superfamily
NFX46_RS10085	COG0529	Catalyzes the synthesis of activated sulfate
NFX46_RS10090	COG0175	sulfate reduction
NFX46_RS10120	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS10135	COG4977	sequence-specific DNA binding
NFX46_RS10135	COG1917	Cupin 2, conserved barrel domain protein
NFX46_RS10165	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NFX46_RS10175	COG1733	regulation of RNA biosynthetic process
NFX46_RS10195	COG2040	homocysteine
NFX46_RS10200	COG0531	amino acid
NFX46_RS10225	COG2755	lipolytic protein G-D-S-L family
NFX46_RS10275	COG0395	ABC-type sugar transport system, permease component
NFX46_RS10280	COG1175	transmembrane transport
NFX46_RS10295	COG0277	FAD linked oxidase domain protein
NFX46_RS10310	COG3540	Alkaline phosphatase
NFX46_RS10330	COG1162	GTPase activity
NFX46_RS10370	COG0028	Belongs to the TPP enzyme family
NFX46_RS10400	COG1802	Transcriptional regulator
NFX46_RS10410	COG3835	regulator
NFX46_RS10425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NFX46_RS10430	COG2252	PERMEase
NFX46_RS10450	COG0726	polysaccharide deacetylase
NFX46_RS10455	COG3940	Belongs to the glycosyl hydrolase 43 family
NFX46_RS10460	COG1309	transcriptional regulator
NFX46_RS10480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NFX46_RS10500	COG2197	response regulator
NFX46_RS10505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NFX46_RS10510	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS10520	COG3960	tartronate-semialdehyde synthase activity
NFX46_RS10530	COG2084	Dehydrogenase
NFX46_RS10535	COG3622	Belongs to the hyi family
NFX46_RS10555	COG2351	hydroxyisourate hydrolase activity
NFX46_RS10570	COG2233	PERMEase
NFX46_RS10595	COG0406	alpha-ribazole phosphatase activity
NFX46_RS10600	COG0436	Aminotransferase
NFX46_RS10615	COG2304	oxidoreductase activity
NFX46_RS10640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NFX46_RS10645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NFX46_RS10645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NFX46_RS10655	COG1414	Transcriptional regulator
NFX46_RS10660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NFX46_RS10665	COG4266	Belongs to the allantoicase family
NFX46_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS10700	COG2197	response regulator
NFX46_RS10710	COG0673	inositol 2-dehydrogenase activity
NFX46_RS10715	COG2188	Transcriptional regulator
NFX46_RS10730	COG1129	ABC transporter
NFX46_RS10735	COG1940	carbohydrate kinase activity
NFX46_RS10745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NFX46_RS10760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NFX46_RS10775	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS10790	COG1278	Cold shock
NFX46_RS10805	COG2072	flavoprotein involved in K transport
NFX46_RS10850	COG1295	ribonuclease BN
NFX46_RS10855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NFX46_RS10860	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NFX46_RS10880	COG1126	abc transporter atp-binding protein
NFX46_RS10895	COG0405	Gamma-glutamyltransferase
NFX46_RS10900	COG0542	response to heat
NFX46_RS10930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NFX46_RS10940	COG1953	Uracil, thiamine, allantoin
NFX46_RS10965	COG0483	inositol monophosphate 1-phosphatase activity
NFX46_RS10975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NFX46_RS10980	COG0243	molybdopterin cofactor binding
NFX46_RS11000	COG0640	Transcriptional regulator
NFX46_RS11020	COG3250	beta-galactosidase activity
NFX46_RS11030	COG0494	nUDIX hydrolase
NFX46_RS11040	COG1929	Belongs to the glycerate kinase type-1 family
NFX46_RS11050	COG0688	phosphatidylethanolamine metabolic process
NFX46_RS11055	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS11065	COG2301	Belongs to the HpcH HpaI aldolase family
NFX46_RS11070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS11070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NFX46_RS11075	COG0604	alcohol dehydrogenase
NFX46_RS11085	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFX46_RS11095	COG0456	acetyltransferase
NFX46_RS11105	COG0596	Alpha beta hydrolase
NFX46_RS11125	COG2172	sigma factor antagonist activity
NFX46_RS11125	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS11125	COG2208	phosphoserine phosphatase activity
NFX46_RS11130	COG2226	methyltransferase
NFX46_RS11140	COG1595	DNA-templated transcription, initiation
NFX46_RS11145	COG2362	D-Aminopeptidase
NFX46_RS11150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NFX46_RS11155	COG1506	peptidase
NFX46_RS11155	COG0823	Involved in the tonB-independent uptake of proteins
NFX46_RS11155	COG4946	Tricorn protease homolog
NFX46_RS11160	COG1619	proteins homologs of microcin C7 resistance protein MccF
NFX46_RS11195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS11270	COG2226	methyltransferase
NFX46_RS11275	COG0406	alpha-ribazole phosphatase activity
NFX46_RS11280	COG0488	(ABC) transporter
NFX46_RS11290	COG0693	protein deglycase activity
NFX46_RS11300	COG0028	Belongs to the TPP enzyme family
NFX46_RS11400	COG2154	pterin-4-alpha-carbinolamine dehydratase
NFX46_RS11405	COG4106	trans-aconitate 2-methyltransferase activity
NFX46_RS11405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NFX46_RS11420	COG2378	regulation of single-species biofilm formation
NFX46_RS11425	COG3401	FG-GAP repeat protein
NFX46_RS11435	COG5297	Belongs to the glycosyl hydrolase family 6
NFX46_RS11435	COG4733	cellulase activity
NFX46_RS11445	COG5297	Belongs to the glycosyl hydrolase family 6
NFX46_RS11460	COG0656	L-ascorbic acid biosynthetic process
NFX46_RS11470	COG0583	DNA-binding transcription factor activity
NFX46_RS11480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NFX46_RS11495	COG3383	formate dehydrogenase (NAD+) activity
NFX46_RS11500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NFX46_RS11510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NFX46_RS11525	COG1129	ABC transporter
NFX46_RS11530	COG1172	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS11540	COG0673	inositol 2-dehydrogenase activity
NFX46_RS11600	COG2223	nitrite transmembrane transporter activity
NFX46_RS11610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NFX46_RS11620	COG0045	succinate-CoA ligase (ADP-forming) activity
NFX46_RS11630	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS11675	COG2072	flavoprotein involved in K transport
NFX46_RS11685	COG3938	Belongs to the proline racemase family
NFX46_RS11690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NFX46_RS11705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFX46_RS11720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NFX46_RS11760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFX46_RS11785	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS11805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NFX46_RS11830	COG0477	Major facilitator Superfamily
NFX46_RS11840	COG3467	pyridoxamine 5'-phosphate
NFX46_RS11845	COG0477	Major facilitator Superfamily
NFX46_RS11855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NFX46_RS11860	COG1082	Xylose isomerase domain protein TIM barrel
NFX46_RS11860	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NFX46_RS11875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NFX46_RS11880	COG0166	Belongs to the GPI family
NFX46_RS11895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NFX46_RS11930	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS11955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NFX46_RS11960	COG3250	beta-galactosidase activity
NFX46_RS11965	COG0395	ABC-type sugar transport system, permease component
NFX46_RS11970	COG1175	transmembrane transport
NFX46_RS11980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFX46_RS11990	COG1486	melibiose metabolic process
NFX46_RS12010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NFX46_RS12050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NFX46_RS12055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NFX46_RS12065	COG1414	Transcriptional regulator
NFX46_RS12115	COG4770	biotin carboxylase activity
NFX46_RS12125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NFX46_RS12130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NFX46_RS12165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFX46_RS12205	COG0477	Major facilitator Superfamily
NFX46_RS12215	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS12275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NFX46_RS12280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFX46_RS12290	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS12305	COG3511	phospholipase C
NFX46_RS12340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NFX46_RS12345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NFX46_RS12350	COG3485	protocatechuate 3,4-dioxygenase
NFX46_RS12355	COG3485	protocatechuate 3,4-dioxygenase
NFX46_RS12360	COG0183	Belongs to the thiolase family
NFX46_RS12375	COG1846	Transcriptional regulator
NFX46_RS12390	COG1793	dna ligase
NFX46_RS12470	COG1834	amidinotransferase
NFX46_RS12475	COG0488	(ABC) transporter
NFX46_RS12500	COG1515	deoxyribonuclease V activity
NFX46_RS12515	COG3268	Saccharopine dehydrogenase
NFX46_RS12525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NFX46_RS12530	COG0183	Belongs to the thiolase family
NFX46_RS12535	COG1024	Enoyl-CoA hydratase
NFX46_RS12535	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFX46_RS12540	COG0789	Transcriptional regulator
NFX46_RS12550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFX46_RS12555	COG2936	dipeptidyl-peptidase activity
NFX46_RS12565	COG0488	(ABC) transporter
NFX46_RS12575	COG2183	response to ionizing radiation
NFX46_RS12585	COG4977	sequence-specific DNA binding
NFX46_RS12595	COG1024	Enoyl-CoA hydratase
NFX46_RS12610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NFX46_RS12655	COG1134	teichoic acid transport
NFX46_RS12660	COG1562	ergosterol biosynthetic process
NFX46_RS12670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NFX46_RS12680	COG1657	PFAM Prenyltransferase squalene oxidase
NFX46_RS12695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NFX46_RS12700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NFX46_RS12720	COG2365	Tyrosine phosphatase family
NFX46_RS12730	COG3401	FG-GAP repeat protein
NFX46_RS12740	COG2755	lipolytic protein G-D-S-L family
NFX46_RS12795	COG1063	alcohol dehydrogenase
NFX46_RS12800	COG0156	8-amino-7-oxononanoate synthase activity
NFX46_RS12805	COG0583	DNA-binding transcription factor activity
NFX46_RS12835	COG0586	Pfam SNARE associated Golgi protein
NFX46_RS12840	COG1132	(ABC) transporter
NFX46_RS12855	COG0561	phosphatase activity
NFX46_RS12880	COG0183	Belongs to the thiolase family
NFX46_RS12925	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS12935	COG2188	Transcriptional regulator
NFX46_RS12965	COG0673	inositol 2-dehydrogenase activity
NFX46_RS12970	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS12980	COG1609	Transcriptional regulator
NFX46_RS12985	COG0673	inositol 2-dehydrogenase activity
NFX46_RS12990	COG1609	Transcriptional regulator
NFX46_RS13000	COG2186	Transcriptional regulator
NFX46_RS13005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NFX46_RS13010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NFX46_RS13015	COG2828	Protein conserved in bacteria
NFX46_RS13025	COG2814	Major facilitator Superfamily
NFX46_RS13040	COG1129	ABC transporter
NFX46_RS13045	COG1172	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS13055	COG0583	DNA-binding transcription factor activity
NFX46_RS13060	COG0346	lactoylglutathione lyase activity
NFX46_RS13080	COG2267	carboxylic ester hydrolase activity
NFX46_RS13100	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS13105	COG0579	oxidoreductase
NFX46_RS13135	COG1819	glycosyl
NFX46_RS13145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NFX46_RS13155	COG0604	alcohol dehydrogenase
NFX46_RS13155	COG3321	synthase
NFX46_RS13170	COG0235	Class ii aldolase
NFX46_RS13200	COG1126	abc transporter atp-binding protein
NFX46_RS13205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFX46_RS13215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS13220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS13230	COG2197	response regulator
NFX46_RS13240	COG1404	Belongs to the peptidase S8 family
NFX46_RS13260	COG2838	Isocitrate dehydrogenase
NFX46_RS13265	COG0668	transmembrane transport
NFX46_RS13270	COG0531	amino acid
NFX46_RS13280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NFX46_RS13305	COG1132	(ABC) transporter
NFX46_RS13310	COG5006	permease, DMT superfamily
NFX46_RS13315	COG0583	DNA-binding transcription factor activity
NFX46_RS13380	COG1191	sigma factor activity
NFX46_RS13400	COG0210	DNA helicase
NFX46_RS13410	COG1401	restriction endodeoxyribonuclease activity
NFX46_RS13435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NFX46_RS13445	COG1401	restriction endodeoxyribonuclease activity
NFX46_RS13485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NFX46_RS13495	COG2815	serine threonine protein kinase
NFX46_RS13495	COG0515	serine threonine protein kinase
NFX46_RS13500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NFX46_RS13525	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NFX46_RS13540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NFX46_RS13560	COG0297	glycogen (starch) synthase activity
NFX46_RS13565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NFX46_RS13595	COG2186	Transcriptional regulator
NFX46_RS13600	COG4948	Mandelate Racemase Muconate Lactonizing
NFX46_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS13635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NFX46_RS13665	COG0726	polysaccharide deacetylase
NFX46_RS13715	COG0583	DNA-binding transcription factor activity
NFX46_RS13725	COG1053	succinate dehydrogenase
NFX46_RS13730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NFX46_RS13745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS13760	COG3360	Dodecin
NFX46_RS13770	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NFX46_RS13775	COG0121	glutamine amidotransferase
NFX46_RS13780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NFX46_RS13785	COG3572	ergothioneine biosynthetic process
NFX46_RS13860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS13875	COG1609	Transcriptional regulator
NFX46_RS13885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NFX46_RS13895	COG0242	peptide deformylase activity
NFX46_RS13980	COG0542	response to heat
NFX46_RS13990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFX46_RS13990	COG0723	plastoquinol--plastocyanin reductase activity
NFX46_RS13995	COG1556	Lactate utilization protein
NFX46_RS14000	COG1139	Iron-sulfur cluster binding protein
NFX46_RS14005	COG0247	lactate metabolic process
NFX46_RS14010	COG1070	Carbohydrate kinase
NFX46_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS14015	COG3347	Dehydrogenase
NFX46_RS14020	COG4952	isomerase
NFX46_RS14025	COG1129	ABC transporter
NFX46_RS14030	COG1172	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS14040	COG1879	ABC-type sugar transport system periplasmic component
NFX46_RS14055	COG1609	Transcriptional regulator
NFX46_RS14075	COG1357	PFAM Pentapeptide repeats (8 copies)
NFX46_RS14085	COG1309	transcriptional regulator
NFX46_RS14095	COG2706	6-phosphogluconolactonase activity
NFX46_RS14135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFX46_RS14150	COG1796	DNA polymerase
NFX46_RS14150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NFX46_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS14180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NFX46_RS14190	COG1846	Transcriptional regulator
NFX46_RS14195	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS14210	COG4977	sequence-specific DNA binding
NFX46_RS14245	COG0435	Glutathione S-transferase
NFX46_RS14265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFX46_RS14275	COG0667	Aldo Keto reductase
NFX46_RS14340	COG2890	protein-(glutamine-N5) methyltransferase activity
NFX46_RS14360	COG0248	Ppx GppA phosphatase
NFX46_RS14365	COG2274	protein secretion by the type I secretion system
NFX46_RS14420	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NFX46_RS14445	COG1819	glycosyl
NFX46_RS14460	COG1132	(ABC) transporter
NFX46_RS14520	COG1309	transcriptional regulator
NFX46_RS14525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NFX46_RS14545	COG5001	Diguanylate cyclase
NFX46_RS14545	COG3447	MASE1 domain protein
NFX46_RS14545	COG5002	protein histidine kinase activity
NFX46_RS14570	COG1940	carbohydrate kinase activity
NFX46_RS14575	COG1653	transport
NFX46_RS14580	COG1175	transmembrane transport
NFX46_RS14585	COG0395	ABC-type sugar transport system, permease component
NFX46_RS14625	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NFX46_RS14630	COG3340	Belongs to the peptidase S51 family
NFX46_RS14665	COG2261	transglycosylase associated protein
NFX46_RS14690	COG2508	Transcriptional regulator
NFX46_RS14700	COG0411	ABC transporter
NFX46_RS14705	COG0559	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS14720	COG1132	(ABC) transporter
NFX46_RS14750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NFX46_RS14755	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NFX46_RS14760	COG2080	2 iron, 2 sulfur cluster binding
NFX46_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS14795	COG3290	protein histidine kinase activity
NFX46_RS14810	COG1801	Protein of unknown function DUF72
NFX46_RS14820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NFX46_RS14825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NFX46_RS14890	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NFX46_RS14895	COG0714	Associated with various cellular activities
NFX46_RS14930	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NFX46_RS14940	COG2197	response regulator
NFX46_RS14955	COG0739	heme binding
NFX46_RS15030	COG4209	transmembrane transport
NFX46_RS15035	COG1609	Transcriptional regulator
NFX46_RS15080	COG0328	RNA-DNA hybrid ribonuclease activity
NFX46_RS15105	COG0667	Aldo Keto reductase
NFX46_RS15120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS15150	COG2340	Cysteine-rich secretory protein family
NFX46_RS15155	COG1672	PFAM Archaeal ATPase
NFX46_RS15155	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NFX46_RS15165	COG3852	Histidine kinase
NFX46_RS15170	COG0492	ferredoxin-NADP+ reductase activity
NFX46_RS15190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NFX46_RS15210	COG3189	MarR family transcriptional regulator
NFX46_RS15225	COG5002	protein histidine kinase activity
NFX46_RS15250	COG0477	Major facilitator Superfamily
NFX46_RS15320	COG2172	sigma factor antagonist activity
NFX46_RS15325	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS15330	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS15350	COG1191	sigma factor activity
NFX46_RS15375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NFX46_RS15380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NFX46_RS15395	COG0366	Alpha amylase catalytic
NFX46_RS15435	COG0181	hydroxymethylbilane synthase activity
NFX46_RS15455	COG3285	dna ligase
NFX46_RS15455	COG1793	dna ligase
NFX46_RS15460	COG2197	response regulator
NFX46_RS15475	COG1063	alcohol dehydrogenase
NFX46_RS15490	COG2382	esterase
NFX46_RS15495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS15500	COG1535	isochorismatase
NFX46_RS15500	COG3433	isochorismatase activity
NFX46_RS15505	COG1535	isochorismatase
NFX46_RS15505	COG3433	isochorismatase activity
NFX46_RS15510	COG1021	2,3-dihydroxybenzoate-AMP ligase
NFX46_RS15515	COG1169	isochorismate synthase
NFX46_RS15520	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS15525	COG4607	ABC-type enterochelin transport system periplasmic component
NFX46_RS15530	COG2382	esterase
NFX46_RS15535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS15540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS15610	COG0009	L-threonylcarbamoyladenylate synthase
NFX46_RS15620	COG0477	Major facilitator Superfamily
NFX46_RS15630	COG2124	cytochrome p450
NFX46_RS15690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS15695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NFX46_RS15775	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS15840	COG0142	geranyltranstransferase activity
NFX46_RS15870	COG0657	acetylesterase activity
NFX46_RS15880	COG1846	Transcriptional regulator
NFX46_RS15880	COG1940	carbohydrate kinase activity
NFX46_RS15905	COG3583	domain protein
NFX46_RS15945	COG0326	Molecular chaperone. Has ATPase activity
NFX46_RS15980	COG1396	sequence-specific DNA binding
NFX46_RS15995	COG2340	Cysteine-rich secretory protein family
NFX46_RS16030	COG0640	Transcriptional regulator
NFX46_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS16045	COG0137	argininosuccinate synthase activity
NFX46_RS16065	COG3152	Membrane
NFX46_RS16070	COG4977	sequence-specific DNA binding
NFX46_RS16105	COG0745	RESPONSE REGULATOR receiver
NFX46_RS16110	COG2205	protein histidine kinase activity
NFX46_RS16120	COG1309	transcriptional regulator
NFX46_RS16125	COG2755	lipolytic protein G-D-S-L family
NFX46_RS16160	COG1175	transmembrane transport
NFX46_RS16165	COG0395	ABC-type sugar transport system, permease component
NFX46_RS16170	COG0366	Alpha amylase catalytic
NFX46_RS16185	COG4305	rare lipoprotein A
NFX46_RS16205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NFX46_RS16210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NFX46_RS16220	COG0277	FAD linked oxidase domain protein
NFX46_RS16225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NFX46_RS16250	COG0277	FAD linked oxidase domain protein
NFX46_RS16255	COG1597	lipid kinase activity
NFX46_RS16295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NFX46_RS16325	COG0513	Belongs to the DEAD box helicase family
NFX46_RS16380	COG0583	DNA-binding transcription factor activity
NFX46_RS16385	COG0384	phenazine biosynthesis protein PhzF
NFX46_RS16415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFX46_RS16430	COG2308	Evidence 4 Homologs of previously reported genes of
NFX46_RS16430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NFX46_RS16515	COG4941	Belongs to the sigma-70 factor family
NFX46_RS16520	COG3795	YCII-related domain
NFX46_RS16535	COG0738	Major facilitator superfamily
NFX46_RS16550	COG0156	8-amino-7-oxononanoate synthase activity
NFX46_RS16570	COG1595	DNA-templated transcription, initiation
NFX46_RS16580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NFX46_RS16660	COG1653	transport
NFX46_RS16735	COG1278	Cold shock
NFX46_RS16740	COG0513	Belongs to the DEAD box helicase family
NFX46_RS16755	COG2197	response regulator
NFX46_RS16760	COG1132	(ABC) transporter
NFX46_RS16765	COG1132	(ABC) transporter
NFX46_RS16775	COG0515	serine threonine protein kinase
NFX46_RS16795	COG4221	oxidoreductase activity
NFX46_RS16810	COG2814	Major facilitator Superfamily
NFX46_RS16820	COG3708	Transcriptional regulator
NFX46_RS16820	COG2207	Transcriptional regulator
NFX46_RS16825	COG1609	Transcriptional regulator
NFX46_RS16835	COG1129	ABC transporter
NFX46_RS16840	COG1172	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS16845	COG1172	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS16935	COG3290	protein histidine kinase activity
NFX46_RS16940	COG4565	transcriptional regulatory protein
NFX46_RS16960	COG1309	transcriptional regulator
NFX46_RS16980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NFX46_RS16985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS16995	COG0183	Belongs to the thiolase family
NFX46_RS17000	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFX46_RS17000	COG1024	Enoyl-CoA hydratase
NFX46_RS17005	COG1022	Amp-dependent synthetase and ligase
NFX46_RS17010	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS17035	COG2205	protein histidine kinase activity
NFX46_RS17040	COG0745	RESPONSE REGULATOR receiver
NFX46_RS17065	COG1472	Belongs to the glycosyl hydrolase 3 family
NFX46_RS17070	COG5297	Belongs to the glycosyl hydrolase family 6
NFX46_RS17110	COG2249	NAD(P)H dehydrogenase (quinone) activity
NFX46_RS17125	COG2226	methyltransferase
NFX46_RS17180	COG2226	methyltransferase
NFX46_RS17185	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NFX46_RS17205	COG0142	geranyltranstransferase activity
NFX46_RS17210	COG3046	protein related to deoxyribodipyrimidine photolyase
NFX46_RS17215	COG0702	epimerase
NFX46_RS17230	COG2409	Drug exporters of the RND superfamily
NFX46_RS17235	COG0671	phosphoesterase, PA-phosphatase related
NFX46_RS17250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS17265	COG2326	polyphosphate kinase activity
NFX46_RS17315	COG0477	Major facilitator Superfamily
NFX46_RS17325	COG0515	serine threonine protein kinase
NFX46_RS17330	COG0739	heme binding
NFX46_RS17355	COG3250	beta-galactosidase activity
NFX46_RS17385	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS17400	COG0596	Alpha beta hydrolase
NFX46_RS17410	COG1414	Transcriptional regulator
NFX46_RS17420	COG2124	cytochrome p450
NFX46_RS17465	COG2423	ornithine cyclodeaminase activity
NFX46_RS17470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NFX46_RS17485	COG1846	Transcriptional regulator
NFX46_RS17510	COG1278	Cold shock
NFX46_RS17515	COG1191	sigma factor activity
NFX46_RS17540	COG1902	pentaerythritol trinitrate reductase activity
NFX46_RS17555	COG0596	Alpha beta hydrolase
NFX46_RS17575	COG1335	isochorismatase
NFX46_RS17595	COG3250	beta-galactosidase activity
NFX46_RS17625	COG1846	Transcriptional regulator
NFX46_RS17705	COG1404	Belongs to the peptidase S8 family
NFX46_RS17710	COG1674	ftsk spoiiie
NFX46_RS17780	COG0596	Alpha beta hydrolase
NFX46_RS17790	COG3629	intracellular signal transduction
NFX46_RS17790	COG3903	Transcriptional regulator
NFX46_RS17815	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NFX46_RS17865	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS17875	COG0189	ligase activity
NFX46_RS17880	COG3265	gluconokinase activity
NFX46_RS17890	COG1309	transcriptional regulator
NFX46_RS17895	COG4106	trans-aconitate 2-methyltransferase activity
NFX46_RS17980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NFX46_RS17985	COG0183	Belongs to the thiolase family
NFX46_RS17990	COG0789	Transcriptional regulator
NFX46_RS18005	COG0346	lactoylglutathione lyase activity
NFX46_RS18010	COG1595	DNA-templated transcription, initiation
NFX46_RS18050	COG0667	Aldo Keto reductase
NFX46_RS18065	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NFX46_RS18075	COG0395	ABC-type sugar transport system, permease component
NFX46_RS18080	COG1175	transmembrane transport
NFX46_RS18090	COG2188	Transcriptional regulator
NFX46_RS18135	COG3387	PFAM Glycoside hydrolase 15-related
NFX46_RS18145	COG3387	PFAM Glycoside hydrolase 15-related
NFX46_RS18155	COG2909	trisaccharide binding
NFX46_RS18160	COG0477	Major facilitator Superfamily
NFX46_RS18240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NFX46_RS18290	COG0477	Major facilitator Superfamily
NFX46_RS18305	COG0393	Putative heavy-metal-binding
NFX46_RS18365	COG2815	serine threonine protein kinase
NFX46_RS18365	COG0515	serine threonine protein kinase
NFX46_RS18375	COG4733	cellulase activity
NFX46_RS18375	COG5297	Belongs to the glycosyl hydrolase family 6
NFX46_RS18410	COG2226	methyltransferase
NFX46_RS18455	COG0803	Belongs to the bacterial solute-binding protein 9 family
NFX46_RS18465	COG1121	(ABC) transporter
NFX46_RS18470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NFX46_RS18500	COG2182	Extracellular solute-binding protein
NFX46_RS18505	COG1175	transmembrane transport
NFX46_RS18510	COG3833	ABC-type maltose transport systems, permease component
NFX46_RS18515	COG2723	6-phospho-beta-galactosidase activity
NFX46_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS18565	COG1309	transcriptional regulator
NFX46_RS18580	COG2130	NADP-dependent
NFX46_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS18630	COG5183	chlorophyll binding
NFX46_RS18630	COG2133	pyrroloquinoline quinone binding
NFX46_RS18715	COG3397	chitin binding
NFX46_RS18725	COG0509	glycine decarboxylation via glycine cleavage system
NFX46_RS18765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFX46_RS18825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NFX46_RS18830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NFX46_RS18835	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS18885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NFX46_RS18920	COG1191	sigma factor activity
NFX46_RS18940	COG2124	cytochrome p450
NFX46_RS18955	COG1131	(ABC) transporter
NFX46_RS18965	COG2409	Drug exporters of the RND superfamily
NFX46_RS18970	COG0667	Aldo Keto reductase
NFX46_RS18980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFX46_RS19000	COG1733	regulation of RNA biosynthetic process
NFX46_RS19005	COG0477	Major facilitator Superfamily
NFX46_RS19160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS19160	COG2226	methyltransferase
NFX46_RS19160	COG3433	isochorismatase activity
NFX46_RS19170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NFX46_RS19175	COG2375	cellular response to nickel ion
NFX46_RS19175	COG1132	(ABC) transporter
NFX46_RS19180	COG1132	(ABC) transporter
NFX46_RS19185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS19185	COG2226	methyltransferase
NFX46_RS19185	COG3433	isochorismatase activity
NFX46_RS19195	COG1021	2,3-dihydroxybenzoate-AMP ligase
NFX46_RS19220	COG3903	Transcriptional regulator
NFX46_RS19220	COG3629	intracellular signal transduction
NFX46_RS19225	COG0475	glutathione-regulated potassium exporter activity
NFX46_RS19245	COG1024	Enoyl-CoA hydratase
NFX46_RS19250	COG1024	Enoyl-CoA hydratase
NFX46_RS19260	COG2197	response regulator
NFX46_RS19270	COG3433	isochorismatase activity
NFX46_RS19270	COG1535	isochorismatase
NFX46_RS19300	COG1024	Enoyl-CoA hydratase
NFX46_RS19340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NFX46_RS19345	COG3851	Histidine kinase
NFX46_RS19350	COG2197	response regulator
NFX46_RS19355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NFX46_RS19370	COG1131	(ABC) transporter
NFX46_RS19450	COG3293	Transposase
NFX46_RS19560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NFX46_RS19565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NFX46_RS19570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NFX46_RS19580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NFX46_RS19690	COG0657	acetylesterase activity
NFX46_RS19700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFX46_RS19750	COG2409	Drug exporters of the RND superfamily
NFX46_RS19755	COG2205	protein histidine kinase activity
NFX46_RS19760	COG0745	RESPONSE REGULATOR receiver
NFX46_RS19810	COG1132	(ABC) transporter
NFX46_RS19840	COG3397	chitin binding
NFX46_RS19870	COG2755	lipolytic protein G-D-S-L family
NFX46_RS19995	COG0657	acetylesterase activity
NFX46_RS20000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFX46_RS20125	COG2226	methyltransferase
NFX46_RS20160	COG2124	cytochrome p450
NFX46_RS20185	COG0494	nUDIX hydrolase
NFX46_RS20250	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFX46_RS20300	COG4977	sequence-specific DNA binding
NFX46_RS20520	COG3547	Transposase (IS116 IS110 IS902 family)
NFX46_RS20650	COG1595	DNA-templated transcription, initiation
NFX46_RS20710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NFX46_RS20715	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NFX46_RS20720	COG2080	2 iron, 2 sulfur cluster binding
NFX46_RS20960	COG1309	transcriptional regulator
NFX46_RS20965	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS20970	COG0667	Aldo Keto reductase
NFX46_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS20985	COG0726	polysaccharide deacetylase
NFX46_RS21075	COG1959	2 iron, 2 sulfur cluster binding
NFX46_RS21075	COG1295	ribonuclease BN
NFX46_RS21115	COG2132	Multicopper oxidase
NFX46_RS21120	COG0535	radical SAM domain protein
NFX46_RS21145	COG1140	nitrate reductase beta subunit
NFX46_RS21150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NFX46_RS21170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NFX46_RS21215	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NFX46_RS21245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NFX46_RS21290	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS21300	COG0583	DNA-binding transcription factor activity
NFX46_RS21355	COG3866	Pectate lyase
NFX46_RS21370	COG0702	epimerase
NFX46_RS21375	COG1231	oxidoreductase activity
NFX46_RS21390	COG1942	4-Oxalocrotonate Tautomerase
NFX46_RS21405	COG0384	phenazine biosynthesis protein PhzF
NFX46_RS21425	COG4122	O-methyltransferase activity
NFX46_RS21580	COG2267	carboxylic ester hydrolase activity
NFX46_RS21585	COG1846	Transcriptional regulator
NFX46_RS21760	COG0596	Alpha beta hydrolase
NFX46_RS21850	COG5434	Belongs to the glycosyl hydrolase 28 family
NFX46_RS21885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFX46_RS21905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NFX46_RS21945	COG3284	Transcriptional regulator
NFX46_RS21965	COG0395	ABC-type sugar transport system, permease component
NFX46_RS21970	COG3842	ATPase activity
NFX46_RS21975	COG3842	ATPase activity
NFX46_RS22030	COG1309	transcriptional regulator
NFX46_RS22065	COG2815	serine threonine protein kinase
NFX46_RS22065	COG0515	serine threonine protein kinase
NFX46_RS22080	COG1280	lysine exporter protein (LysE YggA)
NFX46_RS22090	COG3844	kynureninase activity
NFX46_RS22100	COG3483	tryptophan 2,3-dioxygenase activity
NFX46_RS22105	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS22110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NFX46_RS22115	COG2151	metal-sulfur cluster biosynthetic enzyme
NFX46_RS22120	COG3396	Phenylacetate-CoA oxygenase
NFX46_RS22130	COG3396	Phenylacetate-CoA oxygenase
NFX46_RS22140	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS22155	COG0604	alcohol dehydrogenase
NFX46_RS22165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS22175	COG1595	DNA-templated transcription, initiation
NFX46_RS22195	COG1733	regulation of RNA biosynthetic process
NFX46_RS22205	COG2814	Major facilitator Superfamily
NFX46_RS22225	COG2315	Protein conserved in bacteria
NFX46_RS22235	COG1309	transcriptional regulator
NFX46_RS22240	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS22250	COG0604	alcohol dehydrogenase
NFX46_RS22250	COG3321	synthase
NFX46_RS22265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NFX46_RS22280	COG0395	ABC-type sugar transport system, permease component
NFX46_RS22285	COG1175	transmembrane transport
NFX46_RS22295	COG3345	alpha-galactosidase
NFX46_RS22300	COG1609	Transcriptional regulator
NFX46_RS22310	COG3507	Belongs to the glycosyl hydrolase 43 family
NFX46_RS22315	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFX46_RS22315	COG0596	Alpha beta hydrolase
NFX46_RS22365	COG1595	DNA-templated transcription, initiation
NFX46_RS22370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NFX46_RS22400	COG0583	DNA-binding transcription factor activity
NFX46_RS22425	COG1309	transcriptional regulator
NFX46_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS22450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NFX46_RS22465	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NFX46_RS22485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NFX46_RS22535	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS22555	COG0539	negative regulation of cytoplasmic translation
NFX46_RS22560	COG1733	regulation of RNA biosynthetic process
NFX46_RS22580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS22580	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NFX46_RS22595	COG1022	Amp-dependent synthetase and ligase
NFX46_RS22595	COG3320	Male sterility
NFX46_RS22615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS22630	COG3135	benzoate transporter
NFX46_RS22675	COG0475	glutathione-regulated potassium exporter activity
NFX46_RS22680	COG0488	(ABC) transporter
NFX46_RS22695	COG0024	Methionine aminopeptidase
NFX46_RS22725	COG0346	lactoylglutathione lyase activity
NFX46_RS22730	COG0640	Transcriptional regulator
NFX46_RS22740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NFX46_RS22775	COG1215	transferase activity, transferring glycosyl groups
NFX46_RS22790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NFX46_RS22795	COG0546	phosphoglycolate phosphatase activity
NFX46_RS22815	COG2192	nodulation
NFX46_RS22830	COG4638	Rieske (2fe-2S)
NFX46_RS22835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NFX46_RS22845	COG0535	radical SAM domain protein
NFX46_RS22850	COG0673	inositol 2-dehydrogenase activity
NFX46_RS22880	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NFX46_RS22890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NFX46_RS22920	COG0667	Aldo Keto reductase
NFX46_RS22965	COG0583	DNA-binding transcription factor activity
NFX46_RS22990	COG2326	polyphosphate kinase activity
NFX46_RS23005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NFX46_RS23005	COG1017	nitric oxide dioxygenase activity
NFX46_RS23010	COG4716	Myosin-crossreactive antigen
NFX46_RS23105	COG0179	Fumarylacetoacetate (FAA) hydrolase
NFX46_RS23115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NFX46_RS23155	COG1595	DNA-templated transcription, initiation
NFX46_RS23165	COG2135	peptidase activity
NFX46_RS23170	COG1278	Cold shock
NFX46_RS23175	COG0604	alcohol dehydrogenase
NFX46_RS23180	COG1476	TRANSCRIPTIONal
NFX46_RS23205	COG3250	beta-galactosidase activity
NFX46_RS23210	COG0395	ABC-type sugar transport system, permease component
NFX46_RS23215	COG1175	transmembrane transport
NFX46_RS23250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NFX46_RS23265	COG0179	Fumarylacetoacetate (FAA) hydrolase
NFX46_RS23275	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS23310	COG1120	ATPase activity
NFX46_RS23320	COG2723	6-phospho-beta-galactosidase activity
NFX46_RS23325	COG3250	beta-galactosidase activity
NFX46_RS23350	COG0789	Transcriptional regulator
NFX46_RS23355	COG0659	secondary active sulfate transmembrane transporter activity
NFX46_RS23370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NFX46_RS23385	COG2382	esterase
NFX46_RS23390	COG1132	(ABC) transporter
NFX46_RS23400	COG1132	(ABC) transporter
NFX46_RS23410	COG1120	ATPase activity
NFX46_RS23415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS23420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS23425	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NFX46_RS23470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFX46_RS23475	COG0601	transmembrane transport
NFX46_RS23480	COG0747	negative chemotaxis
NFX46_RS23495	COG0154	amidase activity
NFX46_RS23560	COG1834	amidinotransferase
NFX46_RS23585	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NFX46_RS23590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS23595	COG0604	alcohol dehydrogenase
NFX46_RS23595	COG3321	synthase
NFX46_RS23600	COG0604	alcohol dehydrogenase
NFX46_RS23600	COG3321	synthase
NFX46_RS23605	COG3321	synthase
NFX46_RS23605	COG0604	alcohol dehydrogenase
NFX46_RS23645	COG2124	cytochrome p450
NFX46_RS23655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS23675	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NFX46_RS23675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS23680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS23700	COG0022	dehydrogenase e1 component
NFX46_RS23705	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFX46_RS23715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NFX46_RS23755	COG1278	Cold shock
NFX46_RS23765	COG3896	Chloramphenicol phosphotransferase-like protein
NFX46_RS23770	COG4213	ABC transporter substrate-binding protein
NFX46_RS23775	COG4214	carbohydrate transport
NFX46_RS23795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NFX46_RS23815	COG0753	catalase activity
NFX46_RS23830	COG0740	serine-type endopeptidase activity
NFX46_RS23835	COG0740	serine-type endopeptidase activity
NFX46_RS23840	COG1396	sequence-specific DNA binding
NFX46_RS23845	COG1191	sigma factor activity
NFX46_RS23875	COG1716	ATPase activity
NFX46_RS23875	COG0842	Transport permease protein
NFX46_RS23875	COG1131	(ABC) transporter
NFX46_RS23890	COG0667	Aldo Keto reductase
NFX46_RS23895	COG0583	DNA-binding transcription factor activity
NFX46_RS23905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFX46_RS23910	COG0346	lactoylglutathione lyase activity
NFX46_RS23935	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS23950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS23960	COG0431	NADPH-dependent FMN reductase
NFX46_RS23980	COG1846	Transcriptional regulator
NFX46_RS23985	COG0702	epimerase
NFX46_RS24005	COG0640	Transcriptional regulator
NFX46_RS24010	COG0596	Alpha beta hydrolase
NFX46_RS24035	COG0069	glutamate synthase activity
NFX46_RS24040	COG2267	carboxylic ester hydrolase activity
NFX46_RS24050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NFX46_RS24050	COG3320	Male sterility
NFX46_RS24055	COG0604	alcohol dehydrogenase
NFX46_RS24055	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS24055	COG3321	synthase
NFX46_RS24065	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS24075	COG0673	inositol 2-dehydrogenase activity
NFX46_RS24140	COG1024	Enoyl-CoA hydratase
NFX46_RS24160	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS24175	COG2070	2-Nitropropane dioxygenase
NFX46_RS24200	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS24225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NFX46_RS24240	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NFX46_RS24270	COG0640	Transcriptional regulator
NFX46_RS24285	COG2376	Dihydroxyacetone kinase
NFX46_RS24290	COG1461	Dihydroxyacetone kinase
NFX46_RS24335	COG0446	pyridine nucleotide-disulphide oxidoreductase
NFX46_RS24335	COG1902	pentaerythritol trinitrate reductase activity
NFX46_RS24355	COG2890	protein-(glutamine-N5) methyltransferase activity
NFX46_RS24375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NFX46_RS24380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NFX46_RS24390	COG3458	cephalosporin-C deacetylase activity
NFX46_RS24395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFX46_RS24400	COG2188	Transcriptional regulator
NFX46_RS24405	COG2226	methyltransferase
NFX46_RS24425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NFX46_RS24430	COG1686	Belongs to the peptidase S11 family
NFX46_RS24450	COG2066	Belongs to the glutaminase family
NFX46_RS24465	COG1113	amino acid transport
NFX46_RS24470	COG2186	Transcriptional regulator
NFX46_RS24475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NFX46_RS24480	COG1993	acr, cog1993
NFX46_RS24485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NFX46_RS24495	COG0640	Transcriptional regulator
NFX46_RS24510	COG1653	transport
NFX46_RS24515	COG1175	transmembrane transport
NFX46_RS24520	COG0395	ABC-type sugar transport system, permease component
NFX46_RS24565	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS24590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFX46_RS24595	COG2192	nodulation
NFX46_RS24605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NFX46_RS24610	COG0859	PFAM glycosyl transferase family 9
NFX46_RS24620	COG0297	glycogen (starch) synthase activity
NFX46_RS24625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NFX46_RS24630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NFX46_RS24630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NFX46_RS24730	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NFX46_RS24735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NFX46_RS24740	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NFX46_RS24750	COG2409	Drug exporters of the RND superfamily
NFX46_RS24775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NFX46_RS24800	COG0309	Hydrogenase expression formation protein (HypE)
NFX46_RS24810	COG0298	carbon dioxide binding
NFX46_RS24815	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NFX46_RS24820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NFX46_RS24825	COG0375	protein maturation
NFX46_RS24865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NFX46_RS24865	COG1024	Enoyl-CoA hydratase
NFX46_RS24895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NFX46_RS24905	COG1819	glycosyl
NFX46_RS24935	COG0667	Aldo Keto reductase
NFX46_RS24960	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NFX46_RS24980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFX46_RS25070	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS25095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NFX46_RS25100	COG1215	transferase activity, transferring glycosyl groups
NFX46_RS25125	COG0464	growth
NFX46_RS25135	COG1349	DNA-binding transcription factor activity
NFX46_RS25185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NFX46_RS25190	COG1940	carbohydrate kinase activity
NFX46_RS25200	COG2813	Specifically methylates the guanine in position
NFX46_RS25205	COG0191	fructose-bisphosphate aldolase activity
NFX46_RS25210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NFX46_RS25215	COG1349	DNA-binding transcription factor activity
NFX46_RS25230	COG0738	Major facilitator superfamily
NFX46_RS25255	COG2197	response regulator
NFX46_RS25260	COG4585	Histidine kinase
NFX46_RS25270	COG0445	tRNA wobble uridine modification
NFX46_RS25285	COG1660	Displays ATPase and GTPase activities
NFX46_RS25325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NFX46_RS25350	COG0204	Acyl-transferase
NFX46_RS25375	COG0584	glycerophosphoryl diester phosphodiesterase
NFX46_RS25395	COG0667	Aldo Keto reductase
NFX46_RS25420	COG0671	phosphoesterase, PA-phosphatase related
NFX46_RS25435	COG1309	transcriptional regulator
NFX46_RS25465	COG0640	Transcriptional regulator
NFX46_RS25470	COG1902	pentaerythritol trinitrate reductase activity
NFX46_RS25480	COG3509	depolymerase
NFX46_RS25495	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS25520	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NFX46_RS25565	COG1278	Cold shock
NFX46_RS25585	COG0714	Associated with various cellular activities
NFX46_RS25600	COG2318	DinB family
NFX46_RS25620	COG0714	Associated with various cellular activities
NFX46_RS25655	COG0492	ferredoxin-NADP+ reductase activity
NFX46_RS25665	COG1132	(ABC) transporter
NFX46_RS25680	COG1132	(ABC) transporter
NFX46_RS25690	COG0254	rRNA binding
NFX46_RS25705	COG1946	Acyl-CoA thioesterase
NFX46_RS25715	COG2018	Roadblock/LC7 domain
NFX46_RS25785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NFX46_RS25815	COG1940	carbohydrate kinase activity
NFX46_RS25815	COG1846	Transcriptional regulator
NFX46_RS25830	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS25845	COG3693	PFAM glycoside hydrolase, family 10
NFX46_RS25850	COG1408	metallophosphoesterase
NFX46_RS25880	COG0202	RNA polymerase activity
NFX46_RS25970	COG1231	oxidoreductase activity
NFX46_RS25975	COG1090	epimerase
NFX46_RS26000	COG3629	intracellular signal transduction
NFX46_RS26000	COG3903	Transcriptional regulator
NFX46_RS26025	COG1295	ribonuclease BN
NFX46_RS26045	COG4172	Belongs to the ABC transporter superfamily
NFX46_RS26050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFX46_RS26055	COG0601	transmembrane transport
NFX46_RS26060	COG0747	negative chemotaxis
NFX46_RS26075	COG4948	Mandelate Racemase Muconate Lactonizing
NFX46_RS26080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NFX46_RS26090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NFX46_RS26125	COG0662	Cupin 2, conserved barrel domain protein
NFX46_RS26135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFX46_RS26140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NFX46_RS26145	COG2867	negative regulation of translational initiation
NFX46_RS26165	COG2764	glyoxalase bleomycin resistance protein dioxygenase
NFX46_RS26190	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NFX46_RS26195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NFX46_RS26215	COG2124	cytochrome p450
NFX46_RS26220	COG3251	PFAM MbtH domain protein
NFX46_RS26225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS26225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS26230	COG1132	(ABC) transporter
NFX46_RS26250	COG0444	Belongs to the ABC transporter superfamily
NFX46_RS26255	COG4608	Belongs to the ABC transporter superfamily
NFX46_RS26260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NFX46_RS26270	COG0789	Transcriptional regulator
NFX46_RS26295	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS26300	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS26315	COG3634	alkyl hydroperoxide reductase activity
NFX46_RS26320	COG1793	dna ligase
NFX46_RS26340	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS26350	COG0242	peptide deformylase activity
NFX46_RS26360	COG3442	glutamine amidotransferase
NFX46_RS26365	COG0205	6-phosphofructokinase activity
NFX46_RS26380	COG3275	phosphorelay sensor kinase activity
NFX46_RS26385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFX46_RS26395	COG3279	Response regulator of the LytR AlgR family
NFX46_RS26400	COG1522	sequence-specific DNA binding
NFX46_RS26405	COG1834	amidinotransferase
NFX46_RS26410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NFX46_RS26440	COG0829	nickel cation binding
NFX46_RS26445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NFX46_RS26450	COG0830	nickel cation binding
NFX46_RS26455	COG0804	urea catabolic process
NFX46_RS26460	COG0832	Belongs to the urease beta subunit family
NFX46_RS26465	COG0831	urea catabolic process
NFX46_RS26470	COG1309	transcriptional regulator
NFX46_RS26485	COG0740	serine-type endopeptidase activity
NFX46_RS26520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NFX46_RS26525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NFX46_RS26530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NFX46_RS26540	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NFX46_RS26545	COG2226	methyltransferase
NFX46_RS26560	COG0577	efflux transmembrane transporter activity
NFX46_RS26560	COG1136	(ABC) transporter
NFX46_RS26565	COG0577	efflux transmembrane transporter activity
NFX46_RS26765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NFX46_RS26790	COG4585	Histidine kinase
NFX46_RS26795	COG2197	response regulator
NFX46_RS26800	COG1940	carbohydrate kinase activity
NFX46_RS26805	COG2188	Transcriptional regulator
NFX46_RS26810	COG1595	DNA-templated transcription, initiation
NFX46_RS26815	COG0596	Alpha beta hydrolase
NFX46_RS26825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFX46_RS26840	COG0626	cystathionine gamma-synthase activity
NFX46_RS26860	COG1522	sequence-specific DNA binding
NFX46_RS26865	COG0419	ATPase involved in DNA repair
NFX46_RS26870	COG0420	3'-5' exonuclease activity
NFX46_RS26920	COG1739	Uncharacterized protein family UPF0029
NFX46_RS26930	COG0215	cysteine-tRNA ligase activity
NFX46_RS26935	COG1832	CoA-binding protein
NFX46_RS26960	COG0110	maltose O-acetyltransferase activity
NFX46_RS26980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NFX46_RS27010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NFX46_RS27025	COG0183	Belongs to the thiolase family
NFX46_RS27045	COG1968	undecaprenyl-diphosphatase activity
NFX46_RS27075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NFX46_RS27090	COG2318	DinB family
NFX46_RS27105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NFX46_RS27110	COG4166	transmembrane transport
NFX46_RS27155	COG0697	spore germination
NFX46_RS27195	COG1695	Transcriptional regulator
NFX46_RS27230	COG0384	phenazine biosynthesis protein PhzF
NFX46_RS27255	COG1609	Transcriptional regulator
NFX46_RS27265	COG0395	ABC-type sugar transport system, permease component
NFX46_RS27270	COG1175	transmembrane transport
NFX46_RS27305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NFX46_RS27305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NFX46_RS27320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NFX46_RS27340	COG1716	ATPase activity
NFX46_RS27360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NFX46_RS27390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NFX46_RS27400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NFX46_RS27415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NFX46_RS27425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NFX46_RS27440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NFX46_RS27475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NFX46_RS27480	COG2146	nitrite reductase [NAD(P)H] activity
NFX46_RS27485	COG1414	Transcriptional regulator
NFX46_RS27500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFX46_RS27510	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS27515	COG0531	amino acid
NFX46_RS27545	COG2814	Major facilitator Superfamily
NFX46_RS27550	COG4336	lyase activity
NFX46_RS27555	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NFX46_RS27560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NFX46_RS27565	COG1984	allophanate hydrolase subunit 2
NFX46_RS27580	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS27610	COG2364	Membrane
NFX46_RS27620	COG2270	Major facilitator Superfamily
NFX46_RS27635	COG1216	Glycosyl transferase, family 2
NFX46_RS27655	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS27680	COG0237	dephospho-CoA kinase activity
NFX46_RS27705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NFX46_RS27710	COG0140	phosphoribosyl-ATP diphosphatase activity
NFX46_RS27715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NFX46_RS27720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NFX46_RS27720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NFX46_RS27725	COG3201	nicotinamide mononucleotide transporter
NFX46_RS27740	COG1940	carbohydrate kinase activity
NFX46_RS27740	COG1846	Transcriptional regulator
NFX46_RS27745	COG2223	nitrite transmembrane transporter activity
NFX46_RS27765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NFX46_RS27780	COG0531	amino acid
NFX46_RS27800	COG2390	Transcriptional regulator
NFX46_RS27805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NFX46_RS27815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NFX46_RS27830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NFX46_RS27840	COG1758	RNA polymerase activity
NFX46_RS27845	COG0194	GDP metabolic process
NFX46_RS27855	COG0284	orotidine-5'-phosphate decarboxylase activity
NFX46_RS27860	COG0167	dihydroorotate dehydrogenase activity
NFX46_RS27865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NFX46_RS27870	COG0505	Belongs to the CarA family
NFX46_RS27880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NFX46_RS27885	COG0540	Belongs to the ATCase OTCase family
NFX46_RS27890	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NFX46_RS27900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NFX46_RS27905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NFX46_RS27910	COG0006	proline dipeptidase activity
NFX46_RS27920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NFX46_RS27930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NFX46_RS27935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NFX46_RS27940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NFX46_RS27945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NFX46_RS27950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NFX46_RS27965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NFX46_RS27980	COG0124	histidyl-tRNA synthetase
NFX46_RS27990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NFX46_RS27995	COG1196	nuclear chromosome segregation
NFX46_RS28010	COG0515	serine threonine protein kinase
NFX46_RS28015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NFX46_RS28020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NFX46_RS28025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NFX46_RS28030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NFX46_RS28040	COG2255	four-way junction helicase activity
NFX46_RS28045	COG0632	four-way junction helicase activity
NFX46_RS28050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NFX46_RS28055	COG0217	transcriptional regulatory protein
NFX46_RS28060	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NFX46_RS28065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NFX46_RS28075	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS28080	COG1560	Kdo2-lipid A biosynthetic process
NFX46_RS28085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NFX46_RS28105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NFX46_RS28110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NFX46_RS28125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NFX46_RS28155	COG0395	ABC-type sugar transport system, permease component
NFX46_RS28160	COG1175	transmembrane transport
NFX46_RS28165	COG1653	transport
NFX46_RS28215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NFX46_RS28275	COG1648	precorrin-2 dehydrogenase activity
NFX46_RS28275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NFX46_RS28280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NFX46_RS28295	COG1464	Belongs to the NlpA lipoprotein family
NFX46_RS28300	COG1464	Belongs to the NlpA lipoprotein family
NFX46_RS28305	COG2011	ABC-type metal ion transport system permease component
NFX46_RS28310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NFX46_RS28335	COG0584	glycerophosphoryl diester phosphodiesterase
NFX46_RS28340	COG0204	Acyl-transferase
NFX46_RS28340	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS28345	COG0477	Major facilitator Superfamily
NFX46_RS28360	COG0165	Argininosuccinate lyase
NFX46_RS28385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NFX46_RS28385	COG1017	nitric oxide dioxygenase activity
NFX46_RS28400	COG1438	arginine binding
NFX46_RS28405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NFX46_RS28410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NFX46_RS28415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NFX46_RS28420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NFX46_RS28455	COG0697	spore germination
NFX46_RS28465	COG1649	PFAM Uncharacterised BCR, COG1649
NFX46_RS28490	COG0072	phenylalanine-tRNA ligase activity
NFX46_RS28490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NFX46_RS28495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NFX46_RS28500	COG5002	protein histidine kinase activity
NFX46_RS28505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NFX46_RS28510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NFX46_RS28515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NFX46_RS28520	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NFX46_RS28560	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS28565	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS28570	COG0174	glutamine synthetase
NFX46_RS28605	COG4176	ABC-type proline glycine betaine transport system permease component
NFX46_RS28610	COG0517	IMP dehydrogenase activity
NFX46_RS28610	COG4175	Glycine betaine
NFX46_RS28615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NFX46_RS28670	COG0805	protein transport
NFX46_RS28675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NFX46_RS28705	COG0545	Peptidyl-prolyl cis-trans isomerase
NFX46_RS28710	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NFX46_RS28720	COG1609	Transcriptional regulator
NFX46_RS28725	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NFX46_RS28730	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NFX46_RS28740	COG4122	O-methyltransferase activity
NFX46_RS28745	COG1222	aaa ATPase
NFX46_RS28765	COG0517	IMP dehydrogenase activity
NFX46_RS28765	COG1994	Peptidase M50
NFX46_RS28775	COG2197	response regulator
NFX46_RS28780	COG4166	transmembrane transport
NFX46_RS28785	COG0747	negative chemotaxis
NFX46_RS28795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NFX46_RS28800	COG1410	methionine synthase
NFX46_RS28800	COG0646	methionine synthase
NFX46_RS28805	COG1414	Transcriptional regulator
NFX46_RS28810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NFX46_RS28815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NFX46_RS28820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NFX46_RS28840	COG0215	cysteine-tRNA ligase activity
NFX46_RS28855	COG0406	alpha-ribazole phosphatase activity
NFX46_RS28860	COG0598	Magnesium transport protein CorA
NFX46_RS28870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS28875	COG0667	Aldo Keto reductase
NFX46_RS28905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NFX46_RS28920	COG0308	aminopeptidase N
NFX46_RS28925	COG3012	SEC-C Motif Domain Protein
NFX46_RS28930	COG2186	Transcriptional regulator
NFX46_RS28935	COG3265	gluconokinase activity
NFX46_RS28970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NFX46_RS28975	COG2149	membrane
NFX46_RS29010	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS29020	COG3876	Protein conserved in bacteria
NFX46_RS29050	COG0789	Transcriptional regulator
NFX46_RS29070	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS29120	COG2851	Citrate transporter
NFX46_RS29125	COG0243	molybdopterin cofactor binding
NFX46_RS29130	COG1309	transcriptional regulator
NFX46_RS29140	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NFX46_RS29145	COG2188	Transcriptional regulator
NFX46_RS29185	COG1595	DNA-templated transcription, initiation
NFX46_RS29205	COG0515	serine threonine protein kinase
NFX46_RS29205	COG2815	serine threonine protein kinase
NFX46_RS29210	COG2755	lipolytic protein G-D-S-L family
NFX46_RS29220	COG0463	Glycosyl transferase, family 2
NFX46_RS29245	COG1725	Transcriptional regulator
NFX46_RS29285	COG0662	Cupin 2, conserved barrel domain protein
NFX46_RS29285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NFX46_RS29295	COG0587	DNA-directed DNA polymerase activity
NFX46_RS29320	COG1126	abc transporter atp-binding protein
NFX46_RS29330	COG0765	amino acid transport
NFX46_RS29335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFX46_RS29345	COG1799	cell septum assembly
NFX46_RS29350	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS29355	COG0477	Major facilitator Superfamily
NFX46_RS29365	COG0671	phosphoesterase, PA-phosphatase related
NFX46_RS29390	COG1160	GTP binding
NFX46_RS29400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NFX46_RS29420	COG1397	ADP-ribosylglycohydrolase
NFX46_RS29430	COG1187	pseudouridine synthase activity
NFX46_RS29435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NFX46_RS29440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NFX46_RS29455	COG0686	Belongs to the AlaDH PNT family
NFX46_RS29465	COG0494	nUDIX hydrolase
NFX46_RS29470	COG0504	CTP synthase activity
NFX46_RS29475	COG3387	PFAM Glycoside hydrolase 15-related
NFX46_RS29485	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS29495	COG0497	DNA recombination
NFX46_RS29500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NFX46_RS29520	COG1120	ATPase activity
NFX46_RS29525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS29530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS29535	COG0647	UMP catabolic process
NFX46_RS29570	COG2094	Belongs to the DNA glycosylase MPG family
NFX46_RS29580	COG1881	PFAM PEBP family protein
NFX46_RS29600	COG1119	ATPase activity
NFX46_RS29620	COG2197	response regulator
NFX46_RS29630	COG4221	oxidoreductase activity
NFX46_RS29635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NFX46_RS29645	COG1716	ATPase activity
NFX46_RS29645	COG1131	(ABC) transporter
NFX46_RS29645	COG0842	Transport permease protein
NFX46_RS29660	COG0560	Phosphoserine phosphatase
NFX46_RS29660	COG3830	Belongs to the UPF0237 family
NFX46_RS29685	COG2186	Transcriptional regulator
NFX46_RS29700	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS29715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NFX46_RS29735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NFX46_RS29740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFX46_RS29755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NFX46_RS29775	COG3387	PFAM Glycoside hydrolase 15-related
NFX46_RS29825	COG0488	(ABC) transporter
NFX46_RS29845	COG0235	Class ii aldolase
NFX46_RS29860	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NFX46_RS29865	COG1492	cobalamin metabolic process
NFX46_RS29880	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NFX46_RS29885	COG1797	cobyrinic acid a,c-diamide synthase activity
NFX46_RS29920	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NFX46_RS29945	COG0765	amino acid transport
NFX46_RS29955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NFX46_RS29960	COG2318	DinB family
NFX46_RS29965	COG0456	acetyltransferase
NFX46_RS29970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NFX46_RS29975	COG1917	Cupin 2, conserved barrel domain protein
NFX46_RS29980	COG5285	phytanoyl-CoA dioxygenase
NFX46_RS30005	COG1414	Transcriptional regulator
NFX46_RS30020	COG2252	PERMEase
NFX46_RS30025	COG1595	DNA-templated transcription, initiation
NFX46_RS30040	COG4733	cellulase activity
NFX46_RS30050	COG4677	pectinesterase activity
NFX46_RS30055	COG4677	pectinesterase activity
NFX46_RS30060	COG3866	Pectate lyase
NFX46_RS30065	COG2755	lipolytic protein G-D-S-L family
NFX46_RS30075	COG4677	pectinesterase activity
NFX46_RS30095	COG3866	Pectate lyase
NFX46_RS30100	COG0395	ABC-type sugar transport system, permease component
NFX46_RS30115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NFX46_RS30120	COG1802	Transcriptional regulator
NFX46_RS30125	COG1234	tRNA 3'-trailer cleavage
NFX46_RS30140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NFX46_RS30145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFX46_RS30150	COG1349	DNA-binding transcription factor activity
NFX46_RS30165	COG0395	ABC-type sugar transport system, permease component
NFX46_RS30180	COG1309	transcriptional regulator
NFX46_RS30225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NFX46_RS30230	COG2171	N-acyltransferase activity
NFX46_RS30240	COG2151	metal-sulfur cluster biosynthetic enzyme
NFX46_RS30245	COG0822	iron-sulfur transferase activity
NFX46_RS30250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NFX46_RS30255	COG0396	ATPase activity
NFX46_RS30265	COG0719	Fe-S assembly protein
NFX46_RS30280	COG2746	aminoglycoside 3-N-acetyltransferase activity
NFX46_RS30285	COG1131	(ABC) transporter
NFX46_RS30295	COG1612	heme a metabolic process
NFX46_RS30310	COG0109	protoheme IX farnesyltransferase activity
NFX46_RS30320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NFX46_RS30335	COG0363	glucosamine-6-phosphate deaminase activity
NFX46_RS30340	COG0395	ABC-type sugar transport system, permease component
NFX46_RS30345	COG1175	transmembrane transport
NFX46_RS30350	COG1653	transport
NFX46_RS30355	COG0366	Alpha amylase catalytic
NFX46_RS30365	COG1695	Transcriptional regulator
NFX46_RS30370	COG1136	(ABC) transporter
NFX46_RS30380	COG0166	Belongs to the GPI family
NFX46_RS30390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NFX46_RS30395	COG0149	triose-phosphate isomerase activity
NFX46_RS30400	COG0126	phosphoglycerate kinase activity
NFX46_RS30405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NFX46_RS30415	COG1481	regulation of sporulation
NFX46_RS30420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NFX46_RS30425	COG1660	Displays ATPase and GTPase activities
NFX46_RS30430	COG0322	excinuclease ABC activity
NFX46_RS30445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NFX46_RS30460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFX46_RS30465	COG0765	amino acid transport
NFX46_RS30475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NFX46_RS30480	COG1619	proteins homologs of microcin C7 resistance protein MccF
NFX46_RS30485	COG0477	Major facilitator Superfamily
NFX46_RS30490	COG0387	Pfam Sodium calcium exchanger
NFX46_RS30510	COG0556	nucleotide-excision repair
NFX46_RS30520	COG0584	glycerophosphoryl diester phosphodiesterase
NFX46_RS30530	COG0346	lactoylglutathione lyase activity
NFX46_RS30535	COG2313	pseudouridylate synthase activity
NFX46_RS30540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NFX46_RS30540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NFX46_RS30545	COG2226	methyltransferase
NFX46_RS30550	COG0598	Magnesium transport protein CorA
NFX46_RS30585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NFX46_RS30590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFX46_RS30635	COG0402	S-adenosylhomocysteine deaminase activity
NFX46_RS30675	COG2226	methyltransferase
NFX46_RS30690	COG0237	dephospho-CoA kinase activity
NFX46_RS30715	COG1643	Atp-dependent helicase
NFX46_RS30755	COG2050	protein possibly involved in aromatic compounds catabolism
NFX46_RS30785	COG0411	ABC transporter
NFX46_RS30815	COG0737	Belongs to the 5'-nucleotidase family
NFX46_RS30835	COG1605	Chorismate mutase
NFX46_RS30835	COG0287	Prephenate dehydrogenase
NFX46_RS30845	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS30855	COG1024	Enoyl-CoA hydratase
NFX46_RS30880	COG0183	Belongs to the thiolase family
NFX46_RS30885	COG1309	transcriptional regulator
NFX46_RS30895	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS30905	COG2304	oxidoreductase activity
NFX46_RS30915	COG0067	glutamate synthase
NFX46_RS30915	COG0069	glutamate synthase activity
NFX46_RS30915	COG0070	glutamate synthase
NFX46_RS30945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFX46_RS30950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NFX46_RS30955	COG2301	Belongs to the HpcH HpaI aldolase family
NFX46_RS30960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NFX46_RS30970	COG0159	tryptophan synthase activity
NFX46_RS30975	COG0133	tryptophan synthase activity
NFX46_RS30980	COG0134	indole-3-glycerol-phosphate synthase activity
NFX46_RS31005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NFX46_RS31020	COG0107	imidazoleglycerol-phosphate synthase activity
NFX46_RS31025	COG0251	oxidation-reduction process
NFX46_RS31030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NFX46_RS31035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NFX46_RS31045	COG0131	Imidazoleglycerol-phosphate dehydratase
NFX46_RS31050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFX46_RS31055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NFX46_RS31070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NFX46_RS31075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NFX46_RS31095	COG1432	Conserved Protein
NFX46_RS31105	COG0587	DNA-directed DNA polymerase activity
NFX46_RS31150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NFX46_RS31160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NFX46_RS31165	COG3599	regulation of cell shape
NFX46_RS31175	COG1799	cell septum assembly
NFX46_RS31180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NFX46_RS31185	COG1496	oxidoreductase activity
NFX46_RS31190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NFX46_RS31195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NFX46_RS31200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NFX46_RS31210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NFX46_RS31215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NFX46_RS31225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NFX46_RS31240	COG0275	rRNA processing
NFX46_RS31250	COG0714	Associated with various cellular activities
NFX46_RS31270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NFX46_RS31280	COG1129	ABC transporter
NFX46_RS31290	COG1309	transcriptional regulator
NFX46_RS31315	COG0352	thiamine-phosphate diphosphorylase activity
NFX46_RS31335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFX46_RS31335	COG2022	thiamine diphosphate biosynthetic process
NFX46_RS31345	COG2022	thiamine diphosphate biosynthetic process
NFX46_RS31350	COG0515	serine threonine protein kinase
NFX46_RS31350	COG2815	serine threonine protein kinase
NFX46_RS31355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NFX46_RS31360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NFX46_RS31365	COG2193	ferroxidase activity
NFX46_RS31370	COG0243	molybdopterin cofactor binding
NFX46_RS31375	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NFX46_RS31385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NFX46_RS31390	COG0205	6-phosphofructokinase activity
NFX46_RS31425	COG1940	carbohydrate kinase activity
NFX46_RS31435	COG0003	Pfam Anion-transporting ATPase
NFX46_RS31450	COG1022	Amp-dependent synthetase and ligase
NFX46_RS31460	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS31510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NFX46_RS31515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NFX46_RS31520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NFX46_RS31525	COG0723	plastoquinol--plastocyanin reductase activity
NFX46_RS31530	COG2010	Cytochrome c
NFX46_RS31535	COG1845	cytochrome c oxidase, subunit III
NFX46_RS31545	COG1376	ErfK ybiS ycfS ynhG family protein
NFX46_RS31555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NFX46_RS31560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NFX46_RS31565	COG1104	cysteine desulfurase activity
NFX46_RS31570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFX46_RS31590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NFX46_RS31600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFX46_RS31605	COG2197	response regulator
NFX46_RS31635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NFX46_RS31655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NFX46_RS31665	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NFX46_RS31675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NFX46_RS31680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NFX46_RS31685	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFX46_RS31695	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NFX46_RS31745	COG0321	lipoyl(octanoyl) transferase activity
NFX46_RS31750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NFX46_RS31770	COG0174	glutamine synthetase
NFX46_RS31830	COG0745	RESPONSE REGULATOR receiver
NFX46_RS31845	COG2197	response regulator
NFX46_RS31880	COG1309	transcriptional regulator
NFX46_RS31905	COG0366	Alpha amylase catalytic
NFX46_RS31910	COG3833	ABC-type maltose transport systems, permease component
NFX46_RS31915	COG1175	transmembrane transport
NFX46_RS31920	COG2182	Extracellular solute-binding protein
NFX46_RS31925	COG1609	Transcriptional regulator
NFX46_RS31935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NFX46_RS31945	COG0174	glutamine synthetase
NFX46_RS31975	COG2814	Major facilitator Superfamily
NFX46_RS31985	COG1309	transcriptional regulator
NFX46_RS31990	COG0477	Major facilitator Superfamily
NFX46_RS31995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NFX46_RS32015	COG1994	Peptidase M50
NFX46_RS32060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NFX46_RS32065	COG1120	ATPase activity
NFX46_RS32075	COG2837	iron assimilation
NFX46_RS32080	COG0672	)-iron permease
NFX46_RS32100	COG1309	transcriptional regulator
NFX46_RS32110	COG2814	Major facilitator Superfamily
NFX46_RS32115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFX46_RS32125	COG3540	Alkaline phosphatase
NFX46_RS32140	COG1136	(ABC) transporter
NFX46_RS32150	COG2259	Doxx family
NFX46_RS32160	COG2197	response regulator
NFX46_RS32160	COG3903	Transcriptional regulator
NFX46_RS32175	COG2197	response regulator
NFX46_RS32195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NFX46_RS32205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS32210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NFX46_RS32250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NFX46_RS32280	COG0557	exoribonuclease II activity
NFX46_RS32285	COG3022	response to hydroperoxide
NFX46_RS32290	COG0800	Aldolase
NFX46_RS32305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NFX46_RS32325	COG2030	dehydratase
NFX46_RS32330	COG2197	response regulator
NFX46_RS32340	COG0477	Major facilitator Superfamily
NFX46_RS32350	COG0860	N-Acetylmuramoyl-L-alanine amidase
NFX46_RS32360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS32395	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS32400	COG1309	transcriptional regulator
NFX46_RS32440	COG3845	ABC transporter
NFX46_RS32455	COG2124	cytochrome p450
NFX46_RS32460	COG0183	Belongs to the thiolase family
NFX46_RS32475	COG4122	O-methyltransferase activity
NFX46_RS32515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NFX46_RS32555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NFX46_RS32600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NFX46_RS32615	COG1358	cellular component organization or biogenesis
NFX46_RS32660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NFX46_RS32665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NFX46_RS32675	COG0477	Major facilitator Superfamily
NFX46_RS32680	COG1309	transcriptional regulator
NFX46_RS32695	COG0667	Aldo Keto reductase
NFX46_RS32700	COG0789	Transcriptional regulator
NFX46_RS32715	COG1741	Belongs to the pirin family
NFX46_RS32730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NFX46_RS32735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NFX46_RS32740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFX46_RS32790	COG2130	NADP-dependent
NFX46_RS32800	COG1172	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS32805	COG1172	Belongs to the binding-protein-dependent transport system permease family
NFX46_RS32815	COG1879	ABC-type sugar transport system periplasmic component
NFX46_RS32820	COG1609	Transcriptional regulator
NFX46_RS32860	COG4214	carbohydrate transport
NFX46_RS32865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFX46_RS32870	COG3940	Belongs to the glycosyl hydrolase 43 family
NFX46_RS32875	COG3507	Belongs to the glycosyl hydrolase 43 family
NFX46_RS32885	COG1733	regulation of RNA biosynthetic process
NFX46_RS32935	COG0395	ABC-type sugar transport system, permease component
NFX46_RS32940	COG1175	transmembrane transport
NFX46_RS32980	COG2267	carboxylic ester hydrolase activity
NFX46_RS32985	COG3386	PFAM SMP-30 Gluconolaconase
NFX46_RS32990	COG1414	Transcriptional regulator
NFX46_RS33010	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS33015	COG0825	malonyl-CoA metabolic process
NFX46_RS33015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NFX46_RS33040	COG1077	Cell shape determining protein MreB Mrl
NFX46_RS33045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFX46_RS33075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFX46_RS33140	COG0515	serine threonine protein kinase
NFX46_RS33140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NFX46_RS33145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NFX46_RS33150	COG0640	Transcriptional regulator
NFX46_RS33155	COG0798	PFAM Bile acid sodium symporter
NFX46_RS33180	COG1070	Carbohydrate kinase
NFX46_RS33195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NFX46_RS33200	COG0358	DNA primase activity
NFX46_RS33210	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NFX46_RS33220	COG2949	membrane
NFX46_RS33225	COG0243	molybdopterin cofactor binding
NFX46_RS33240	COG1733	regulation of RNA biosynthetic process
NFX46_RS33265	COG2146	nitrite reductase [NAD(P)H] activity
NFX46_RS33265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NFX46_RS33275	COG0642	Histidine kinase
NFX46_RS33320	COG1136	(ABC) transporter
NFX46_RS33330	COG0574	Belongs to the PEP-utilizing enzyme family
NFX46_RS33330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NFX46_RS33340	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NFX46_RS33370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NFX46_RS33390	COG0667	Aldo Keto reductase
NFX46_RS33395	COG0423	glycine-tRNA ligase activity
NFX46_RS33400	COG0803	Belongs to the bacterial solute-binding protein 9 family
NFX46_RS33400	COG3443	Belongs to the bacterial solute-binding protein 9 family
NFX46_RS33405	COG1121	(ABC) transporter
NFX46_RS33410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NFX46_RS33420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NFX46_RS33425	COG1381	Involved in DNA repair and RecF pathway recombination
NFX46_RS33470	COG0456	acetyltransferase
NFX46_RS33470	COG1214	PFAM Peptidase M22, glycoprotease
NFX46_RS33490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NFX46_RS33505	COG2723	6-phospho-beta-galactosidase activity
NFX46_RS33510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NFX46_RS33545	COG2315	Protein conserved in bacteria
NFX46_RS33555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NFX46_RS33565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFX46_RS33570	COG4948	Mandelate Racemase Muconate Lactonizing
NFX46_RS33580	COG5297	Belongs to the glycosyl hydrolase family 6
NFX46_RS33580	COG3250	beta-galactosidase activity
NFX46_RS33605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFX46_RS33610	COG1234	tRNA 3'-trailer cleavage
NFX46_RS33615	COG0537	adenosine 5'-monophosphoramidase activity
NFX46_RS33620	COG4946	Tricorn protease homolog
NFX46_RS33620	COG0793	Belongs to the peptidase S41A family
NFX46_RS33645	COG0484	heat shock protein binding
NFX46_RS33650	COG1420	regulation of RNA biosynthetic process
NFX46_RS33680	COG0481	GTPase activity
NFX46_RS33685	COG0268	Binds directly to 16S ribosomal RNA
NFX46_RS33715	COG1555	photosystem II stabilization
NFX46_RS33715	COG1596	polysaccharide export
NFX46_RS33720	COG1307	EDD domain protein, DegV family
NFX46_RS33730	COG0495	leucyl-tRNA aminoacylation
NFX46_RS33740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NFX46_RS33765	COG0588	phosphoglycerate mutase activity
NFX46_RS33770	COG0799	negative regulation of ribosome biogenesis
NFX46_RS33780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NFX46_RS33795	COG0501	Belongs to the peptidase M48B family
NFX46_RS33810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NFX46_RS33820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NFX46_RS33830	COG1215	transferase activity, transferring glycosyl groups
NFX46_RS33850	COG3540	Alkaline phosphatase
NFX46_RS33855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NFX46_RS33860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NFX46_RS33865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NFX46_RS33945	COG0673	inositol 2-dehydrogenase activity
NFX46_RS33950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NFX46_RS33955	COG1530	ribonuclease E activity
NFX46_RS33985	COG0772	Belongs to the SEDS family
NFX46_RS34005	COG1077	Cell shape determining protein MreB Mrl
NFX46_RS34010	COG0105	UTP biosynthetic process
NFX46_RS34020	COG0285	dihydrofolate synthase activity
NFX46_RS34025	COG0525	valine-tRNA ligase activity
NFX46_RS34035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NFX46_RS34040	COG0740	serine-type endopeptidase activity
NFX46_RS34045	COG0740	serine-type endopeptidase activity
NFX46_RS34050	COG0544	peptidyl-prolyl cis-trans isomerase activity
NFX46_RS34070	COG3594	Acyltransferase
NFX46_RS34085	COG4552	Acetyltransferase involved in intracellular survival and related
NFX46_RS34095	COG0698	ribose 5-phosphate isomerase
NFX46_RS34100	COG1113	amino acid transport
NFX46_RS34105	COG1268	BioY protein
NFX46_RS34110	COG1113	amino acid transport
NFX46_RS34115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NFX46_RS34120	COG2409	Drug exporters of the RND superfamily
NFX46_RS34125	COG4585	Histidine kinase
NFX46_RS34130	COG2197	response regulator
NFX46_RS34135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NFX46_RS34215	COG0697	spore germination
NFX46_RS34220	COG1846	Transcriptional regulator
NFX46_RS34245	COG0668	transmembrane transport
NFX46_RS34255	COG1653	transport
NFX46_RS34260	COG1175	transmembrane transport
NFX46_RS34265	COG0395	ABC-type sugar transport system, permease component
NFX46_RS34270	COG1486	melibiose metabolic process
NFX46_RS34285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFX46_RS34315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NFX46_RS34355	COG0629	single-stranded DNA binding
NFX46_RS34410	COG2304	oxidoreductase activity
NFX46_RS34475	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS34500	COG0492	ferredoxin-NADP+ reductase activity
NFX46_RS34555	COG3962	Belongs to the TPP enzyme family
NFX46_RS34560	COG3718	enzyme involved in inositol metabolism
NFX46_RS34570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFX46_RS34590	COG1064	alcohol dehydrogenase
NFX46_RS34595	COG2409	Drug exporters of the RND superfamily
NFX46_RS34620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NFX46_RS34635	COG1129	ABC transporter
NFX46_RS34645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFX46_RS34650	COG1869	D-ribose catabolic process
NFX46_RS34685	COG0673	inositol 2-dehydrogenase activity
NFX46_RS34720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NFX46_RS34730	COG1595	DNA-templated transcription, initiation
NFX46_RS34735	COG1472	Belongs to the glycosyl hydrolase 3 family
NFX46_RS34765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NFX46_RS34770	COG2356	endonuclease I
NFX46_RS34775	COG0028	Belongs to the TPP enzyme family
NFX46_RS34785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFX46_RS34805	COG1946	Acyl-CoA thioesterase
NFX46_RS34820	COG1309	transcriptional regulator
NFX46_RS34825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NFX46_RS34840	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS34860	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NFX46_RS34885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NFX46_RS34895	COG0589	response to stress
NFX46_RS34905	COG4977	sequence-specific DNA binding
NFX46_RS34910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NFX46_RS34940	COG0395	ABC-type sugar transport system, permease component
NFX46_RS34950	COG3979	chitinase
NFX46_RS34960	COG0745	RESPONSE REGULATOR receiver
NFX46_RS34970	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NFX46_RS34985	COG0406	alpha-ribazole phosphatase activity
NFX46_RS35035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFX46_RS35050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NFX46_RS35055	COG0154	amidase activity
NFX46_RS35070	COG0765	amino acid transport
NFX46_RS35075	COG0765	amino acid transport
NFX46_RS35080	COG1126	abc transporter atp-binding protein
NFX46_RS35095	COG3397	chitin binding
NFX46_RS35140	COG0673	inositol 2-dehydrogenase activity
NFX46_RS35145	COG4702	Belongs to the UPF0303 family
NFX46_RS35155	COG0706	membrane insertase activity
NFX46_RS35165	COG3764	Sortase (surface protein transpeptidase)
NFX46_RS35215	COG1074	ATP-dependent DNA helicase activity
NFX46_RS35290	COG2733	membrane
NFX46_RS35305	COG1131	(ABC) transporter
NFX46_RS35320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NFX46_RS35325	COG2076	Multidrug Resistance protein
NFX46_RS35350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NFX46_RS35360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NFX46_RS35365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NFX46_RS35370	COG1263	PTS System
NFX46_RS35375	COG1263	PTS System
NFX46_RS35405	COG1113	amino acid transport
NFX46_RS35415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NFX46_RS35425	COG1335	isochorismatase
NFX46_RS35465	COG0277	FAD linked oxidase domain protein
NFX46_RS35475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NFX46_RS35485	COG1174	glycine betaine transport
NFX46_RS35495	COG1174	glycine betaine transport
NFX46_RS35600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NFX46_RS35605	COG0395	ABC-type sugar transport system, permease component
NFX46_RS35610	COG1175	transmembrane transport
NFX46_RS35625	COG1678	Uncharacterized ACR, COG1678
NFX46_RS35630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NFX46_RS35635	COG0776	regulation of translation
NFX46_RS35645	COG3973	AAA domain
NFX46_RS35670	COG2223	nitrite transmembrane transporter activity
NFX46_RS35680	COG0583	DNA-binding transcription factor activity
NFX46_RS35695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NFX46_RS35700	COG0793	Belongs to the peptidase S41A family
NFX46_RS35710	COG2884	Cell division ATP-binding protein ftsE
NFX46_RS35725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NFX46_RS35730	COG0515	serine threonine protein kinase
NFX46_RS35735	COG0515	serine threonine protein kinase
NFX46_RS35750	COG1175	transmembrane transport
NFX46_RS35755	COG0395	ABC-type sugar transport system, permease component
NFX46_RS35760	COG0463	Glycosyl transferase, family 2
NFX46_RS35760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NFX46_RS35765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NFX46_RS35770	COG1216	Glycosyl transferase, family 2
NFX46_RS35785	COG1764	response to oxidative stress
NFX46_RS35790	COG1846	Transcriptional regulator
NFX46_RS35805	COG1309	transcriptional regulator
NFX46_RS35815	COG1134	teichoic acid transport
NFX46_RS35820	COG2902	Dehydrogenase
NFX46_RS35845	COG0653	protein targeting
NFX46_RS35855	COG3214	Protein conserved in bacteria
NFX46_RS35860	COG2197	response regulator
NFX46_RS35865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NFX46_RS35875	COG0823	Involved in the tonB-independent uptake of proteins
NFX46_RS35880	COG5002	protein histidine kinase activity
NFX46_RS35880	COG5000	phosphorelay sensor kinase activity
NFX46_RS35885	COG0745	RESPONSE REGULATOR receiver
NFX46_RS35890	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NFX46_RS35910	COG0714	Associated with various cellular activities
NFX46_RS35950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NFX46_RS35960	COG1482	cell wall glycoprotein biosynthetic process
NFX46_RS35970	COG2835	tetraacyldisaccharide 4'-kinase activity
NFX46_RS35975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NFX46_RS36010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NFX46_RS36015	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NFX46_RS36015	COG0778	Nitroreductase
NFX46_RS36045	COG1316	TRANSCRIPTIONal
NFX46_RS36055	COG0463	Glycosyl transferase, family 2
NFX46_RS36070	COG1316	TRANSCRIPTIONal
NFX46_RS36085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NFX46_RS36115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NFX46_RS36130	COG2205	protein histidine kinase activity
NFX46_RS36135	COG0745	RESPONSE REGULATOR receiver
NFX46_RS36140	COG3104	oligopeptide transport
NFX46_RS36170	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS36175	COG1191	sigma factor activity
NFX46_RS36185	COG1228	amidohydrolase
NFX46_RS36195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NFX46_RS36200	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NFX46_RS36235	COG2986	histidine ammonia-lyase
NFX46_RS36250	COG4221	oxidoreductase activity
NFX46_RS36265	COG2755	lipolytic protein G-D-S-L family
NFX46_RS36270	COG0183	Belongs to the thiolase family
NFX46_RS36305	COG1136	(ABC) transporter
NFX46_RS36305	COG0577	efflux transmembrane transporter activity
NFX46_RS36310	COG0577	efflux transmembrane transporter activity
NFX46_RS36315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NFX46_RS36320	COG1252	NADH dehydrogenase
NFX46_RS36340	COG0148	phosphopyruvate hydratase activity
NFX46_RS36355	COG2124	cytochrome p450
NFX46_RS36400	COG0577	efflux transmembrane transporter activity
NFX46_RS36405	COG1136	(ABC) transporter
NFX46_RS36410	COG0477	Major facilitator Superfamily
NFX46_RS36420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFX46_RS36450	COG4585	Histidine kinase
NFX46_RS36460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NFX46_RS36465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NFX46_RS36470	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NFX46_RS36475	COG0193	aminoacyl-tRNA hydrolase activity
NFX46_RS36485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NFX46_RS36495	COG1309	transcriptional regulator
NFX46_RS36505	COG4106	trans-aconitate 2-methyltransferase activity
NFX46_RS36515	COG2197	response regulator
NFX46_RS36525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NFX46_RS36610	COG0488	(ABC) transporter
NFX46_RS36615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NFX46_RS36620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NFX46_RS36630	COG0084	hydrolase, TatD family'
NFX46_RS36650	COG0768	penicillin binding
NFX46_RS36665	COG0310	cobalt ion transport
NFX46_RS36675	COG1122	ATPase activity
NFX46_RS36680	COG1846	Transcriptional regulator
NFX46_RS36685	COG1764	response to oxidative stress
NFX46_RS36715	COG2409	Drug exporters of the RND superfamily
NFX46_RS36725	COG4946	Tricorn protease homolog
NFX46_RS36725	COG0793	Belongs to the peptidase S41A family
NFX46_RS36735	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS36740	COG2267	carboxylic ester hydrolase activity
NFX46_RS36745	COG2072	flavoprotein involved in K transport
NFX46_RS36765	COG2197	response regulator
NFX46_RS36785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NFX46_RS36790	COG4106	trans-aconitate 2-methyltransferase activity
NFX46_RS36805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFX46_RS36810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NFX46_RS36820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS36825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFX46_RS36830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NFX46_RS36880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NFX46_RS36885	COG0521	Mo-molybdopterin cofactor biosynthetic process
NFX46_RS36885	COG0315	cyclic pyranopterin monophosphate synthase activity
NFX46_RS36890	COG0315	cyclic pyranopterin monophosphate synthase activity
NFX46_RS36900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NFX46_RS36905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NFX46_RS36920	COG0477	Major facilitator Superfamily
NFX46_RS36930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NFX46_RS36940	COG1970	mechanosensitive ion channel activity
NFX46_RS36975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NFX46_RS36975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NFX46_RS36975	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NFX46_RS36980	COG1105	Belongs to the carbohydrate kinase PfkB family
NFX46_RS36985	COG1349	DNA-binding transcription factor activity
NFX46_RS36990	COG0477	Major facilitator Superfamily
NFX46_RS37010	COG1247	-acetyltransferase
NFX46_RS37015	COG3384	dioxygenase
NFX46_RS37020	COG1846	Transcriptional regulator
NFX46_RS37040	COG1414	Transcriptional regulator
NFX46_RS37080	COG1733	regulation of RNA biosynthetic process
NFX46_RS37105	COG0386	Belongs to the glutathione peroxidase family
NFX46_RS37130	COG1686	Belongs to the peptidase S11 family
NFX46_RS37170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NFX46_RS37200	COG1012	belongs to the aldehyde dehydrogenase family
NFX46_RS37205	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NFX46_RS37215	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS37230	COG3903	Transcriptional regulator
NFX46_RS37230	COG3629	intracellular signal transduction
NFX46_RS37260	COG1024	Enoyl-CoA hydratase
NFX46_RS37270	COG0515	serine threonine protein kinase
NFX46_RS37270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NFX46_RS37280	COG1309	transcriptional regulator
NFX46_RS37285	COG1522	sequence-specific DNA binding
NFX46_RS37290	COG1280	lysine exporter protein (LysE YggA)
NFX46_RS37300	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS37310	COG0259	pyridoxamine-phosphate oxidase activity
NFX46_RS37355	COG2072	flavoprotein involved in K transport
NFX46_RS37360	COG1231	oxidoreductase activity
NFX46_RS37370	COG1024	Enoyl-CoA hydratase
NFX46_RS37415	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS37420	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS37435	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS37440	COG1960	acyl-CoA dehydrogenase activity
NFX46_RS37450	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS37460	COG1366	Belongs to the anti-sigma-factor antagonist family
NFX46_RS37515	COG2945	thiolester hydrolase activity
NFX46_RS37515	COG0596	Alpha beta hydrolase
NFX46_RS37525	COG4821	SIS domain
NFX46_RS37550	COG0259	pyridoxamine-phosphate oxidase activity
NFX46_RS37565	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS37580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NFX46_RS37595	COG5006	permease, DMT superfamily
NFX46_RS37605	COG0277	FAD linked oxidase domain protein
NFX46_RS37610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NFX46_RS37660	COG0667	Aldo Keto reductase
NFX46_RS37685	COG2252	PERMEase
NFX46_RS37695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NFX46_RS37720	COG2814	Major facilitator Superfamily
NFX46_RS37730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NFX46_RS37735	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NFX46_RS37760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NFX46_RS37775	COG1061	Type III restriction enzyme res subunit
NFX46_RS37790	COG3973	AAA domain
NFX46_RS37820	COG1737	Transcriptional regulator
NFX46_RS37825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NFX46_RS37830	COG1263	PTS System
NFX46_RS37830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NFX46_RS37855	COG0459	protein refolding
NFX46_RS37875	COG0463	Glycosyl transferase, family 2
NFX46_RS37910	COG1105	Belongs to the carbohydrate kinase PfkB family
NFX46_RS37920	COG3300	MHYT domain
NFX46_RS37920	COG5001	Diguanylate cyclase
NFX46_RS37990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFX46_RS38010	COG3842	ATPase activity
NFX46_RS38020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NFX46_RS38030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NFX46_RS38035	COG0215	cysteine-tRNA ligase activity
NFX46_RS38040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NFX46_RS38045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NFX46_RS38050	COG1329	Transcriptional regulator
NFX46_RS38065	COG5002	protein histidine kinase activity
NFX46_RS38110	COG2188	Transcriptional regulator
NFX46_RS38155	COG4974	Belongs to the 'phage' integrase family
NFX46_RS38165	COG0588	phosphoglycerate mutase activity
NFX46_RS38195	COG0438	transferase activity, transferring glycosyl groups
NFX46_RS38230	COG2226	methyltransferase
NFX46_RS38265	COG0546	phosphoglycolate phosphatase activity
NFX46_RS38270	COG2186	Transcriptional regulator
NFX46_RS38280	COG2188	Transcriptional regulator
NFX46_RS38285	COG4552	Acetyltransferase involved in intracellular survival and related
NFX46_RS38295	COG1490	D-aminoacyl-tRNA deacylase activity
NFX46_RS38300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NFX46_RS38310	COG3485	protocatechuate 3,4-dioxygenase
NFX46_RS38340	COG2897	thiosulfate sulfurtransferase activity
NFX46_RS38365	COG0745	RESPONSE REGULATOR receiver
NFX46_RS38370	COG1609	Transcriptional regulator
NFX46_RS38375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NFX46_RS38410	COG1136	(ABC) transporter
NFX46_RS38410	COG0577	efflux transmembrane transporter activity
NFX46_RS38425	COG1132	(ABC) transporter
NFX46_RS38430	COG0737	Belongs to the 5'-nucleotidase family
NFX46_RS38435	COG0456	acetyltransferase
NFX46_RS38455	COG1131	(ABC) transporter
NFX46_RS38470	COG1725	Transcriptional regulator
NFX46_RS38475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NFX46_RS38495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NFX46_RS38505	COG0406	alpha-ribazole phosphatase activity
NFX46_RS38505	COG0494	nUDIX hydrolase
NFX46_RS38525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NFX46_RS38530	COG0306	phosphate transporter
NFX46_RS38540	COG1937	Protein conserved in bacteria
NFX46_RS38560	COG0277	FAD linked oxidase domain protein
NFX46_RS38565	COG0671	phosphoesterase, PA-phosphatase related
NFX46_RS38570	COG0739	heme binding
NFX46_RS38570	COG1196	nuclear chromosome segregation
NFX46_RS38570	COG0741	lytic transglycosylase activity
NFX46_RS38645	COG2226	methyltransferase
NFX46_RS38655	COG1252	NADH dehydrogenase
NFX46_RS38685	COG0579	oxidoreductase
NFX46_RS38690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NFX46_RS38715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NFX46_RS38715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NFX46_RS38725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NFX46_RS38730	COG0494	nUDIX hydrolase
NFX46_RS38740	COG1349	DNA-binding transcription factor activity
NFX46_RS38780	COG0513	Belongs to the DEAD box helicase family
NFX46_RS38815	COG1643	Atp-dependent helicase
NFX46_RS38840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NFX46_RS38850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NFX46_RS38865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NFX46_RS38870	COG0047	phosphoribosylformylglycinamidine synthase activity
NFX46_RS38875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NFX46_RS38910	COG2197	response regulator
NFX46_RS38920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NFX46_RS38935	COG0151	Belongs to the GarS family
NFX46_RS38960	COG2197	response regulator
NFX46_RS38980	COG1028	Short-chain dehydrogenase reductase Sdr
NFX46_RS39000	COG2375	cellular response to nickel ion
NFX46_RS39000	COG1132	(ABC) transporter
NFX46_RS39025	COG0433	COG0433 Predicted ATPase
NFX46_RS39040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NFX46_RS39075	COG1191	sigma factor activity
NFX46_RS39080	COG1191	sigma factor activity
NFX46_RS39110	COG3467	pyridoxamine 5'-phosphate
NFX46_RS39120	COG0477	Major facilitator Superfamily
NFX46_RS39125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NFX46_RS39135	COG2205	protein histidine kinase activity
NFX46_RS39140	COG0745	RESPONSE REGULATOR receiver
NFX46_RS39145	COG0596	Alpha beta hydrolase
NFX46_RS39160	COG1846	Transcriptional regulator
NFX46_RS39175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NFX46_RS39180	COG1733	regulation of RNA biosynthetic process
NFX46_RS39220	COG1309	transcriptional regulator
NFX46_RS39225	COG2814	Major facilitator Superfamily
NFX46_RS39230	COG0318	PFAM AMP-dependent synthetase and ligase
NFX46_RS39235	COG1595	DNA-templated transcription, initiation
NFX46_RS39375	COG1196	nuclear chromosome segregation
NFX46_RS39405	COG2188	Transcriptional regulator
NFX46_RS39455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NFX46_RS39470	COG0653	protein targeting
NFX46_RS39490	COG0006	proline dipeptidase activity
NFX46_RS39495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFX46_RS39530	COG1999	signal sequence binding
NFX46_RS39545	COG2837	iron assimilation
NFX46_RS39555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NFX46_RS39560	COG0561	phosphatase activity
NFX46_RS39590	COG1131	(ABC) transporter
NFX46_RS39605	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NFX46_RS39615	COG0561	phosphatase activity
NFX46_RS39620	COG1196	nuclear chromosome segregation
NFX46_RS39620	COG0741	lytic transglycosylase activity
NFX46_RS39620	COG0739	heme binding
NFX46_RS39625	COG4988	ABC transporter
NFX46_RS39630	COG1294	oxidase, subunit
NFX46_RS39635	COG1271	oxidase subunit
NFX46_RS39640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFX46_RS39645	COG1609	Transcriptional regulator
NFX46_RS39665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NFX46_RS39690	COG0662	Cupin 2, conserved barrel domain protein
NFX46_RS39695	COG1950	PFAM Membrane protein of
NFX46_RS39700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NFX46_RS39705	COG0626	cystathionine gamma-synthase activity
NFX46_RS39740	COG2814	Major facilitator Superfamily
NFX46_RS39770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NFX46_RS39775	COG0305	Participates in initiation and elongation during chromosome replication
NFX46_RS39785	COG0359	binds to the 23S rRNA
NFX46_RS39790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NFX46_RS39795	COG0629	single-stranded DNA binding
NFX46_RS39800	COG0360	Binds together with S18 to 16S ribosomal RNA
NFX46_RS39825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NFX46_RS39850	COG0617	tRNA 3'-terminal CCA addition
NFX46_RS39865	COG0515	serine threonine protein kinase
NFX46_RS39865	COG2815	serine threonine protein kinase
NFX46_RS39870	COG1595	DNA-templated transcription, initiation
NFX46_RS39880	COG0492	ferredoxin-NADP+ reductase activity
NFX46_RS39885	COG3118	belongs to the thioredoxin family
NFX46_RS39900	COG1192	Involved in chromosome partitioning
NFX46_RS39905	COG0357	Ribosomal RNA small subunit methyltransferase G
NFX46_RS39915	COG0706	membrane insertase activity
NFX46_RS39920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NFX46_RS39925	COG0594	ribonuclease P activity
NFX46_RS39940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFX46_RS39950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NFX46_RS39965	COG0305	Participates in initiation and elongation during chromosome replication
NFX46_RS39985	COG3629	intracellular signal transduction
NFX46_RS39985	COG3903	Transcriptional regulator
NFX46_RS40030	COG0515	serine threonine protein kinase
NFX46_RS40030	COG2815	serine threonine protein kinase
NFX46_RS40070	COG0515	serine threonine protein kinase
NFX46_RS40070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NFX46_RS40135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NFX46_RS40195	COG1192	Involved in chromosome partitioning
NFX46_RS40245	COG1674	ftsk spoiiie