locus-tag	class	description
LK06_RS00015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK06_RS00020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK06_RS00035	COG2267	carboxylic ester hydrolase activity
LK06_RS00045	COG0559	Belongs to the binding-protein-dependent transport system permease family
LK06_RS00070	COG0789	Transcriptional regulator
LK06_RS00075	COG0659	secondary active sulfate transmembrane transporter activity
LK06_RS00090	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS00095	COG3835	regulator
LK06_RS00100	COG2409	Drug exporters of the RND superfamily
LK06_RS00110	COG0517	IMP dehydrogenase activity
LK06_RS00110	COG0516	GMP reductase activity
LK06_RS00130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK06_RS00130	COG0574	Belongs to the PEP-utilizing enzyme family
LK06_RS00145	COG1063	alcohol dehydrogenase
LK06_RS00170	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LK06_RS00190	COG0617	tRNA 3'-terminal CCA addition
LK06_RS00190	COG0517	IMP dehydrogenase activity
LK06_RS00190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LK06_RS00235	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
LK06_RS00240	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
LK06_RS00275	COG0517	IMP dehydrogenase activity
LK06_RS00280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK06_RS00285	COG0569	domain protein
LK06_RS00345	COG0517	IMP dehydrogenase activity
LK06_RS00345	COG0516	GMP reductase activity
LK06_RS00355	COG1215	transferase activity, transferring glycosyl groups
LK06_RS00365	COG1940	carbohydrate kinase activity
LK06_RS00365	COG1846	Transcriptional regulator
LK06_RS00390	COG1940	carbohydrate kinase activity
LK06_RS00405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK06_RS00410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LK06_RS00415	COG0022	dehydrogenase e1 component
LK06_RS00415	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK06_RS00420	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK06_RS00440	COG1597	lipid kinase activity
LK06_RS00445	COG0277	FAD linked oxidase domain protein
LK06_RS00485	COG3979	chitinase
LK06_RS00490	COG0531	amino acid
LK06_RS00505	COG0038	chloride channel
LK06_RS00520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK06_RS00530	COG1032	radical SAM domain protein
LK06_RS00565	COG0726	polysaccharide deacetylase
LK06_RS00575	COG2837	iron assimilation
LK06_RS00620	COG0667	Aldo Keto reductase
LK06_RS00655	COG3469	chitinase activity
LK06_RS00665	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LK06_RS00740	COG0667	Aldo Keto reductase
LK06_RS00795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK06_RS00820	COG3290	protein histidine kinase activity
LK06_RS00825	COG3387	PFAM Glycoside hydrolase 15-related
LK06_RS00835	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LK06_RS00870	COG1072	(Pantothenic acid kinase))
LK06_RS00895	COG1309	transcriptional regulator
LK06_RS00925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK06_RS00965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK06_RS00975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LK06_RS01005	COG0515	serine threonine protein kinase
LK06_RS01015	COG1132	(ABC) transporter
LK06_RS01020	COG1132	(ABC) transporter
LK06_RS01025	COG2197	response regulator
LK06_RS01060	COG4221	oxidoreductase activity
LK06_RS01100	COG0662	Cupin 2, conserved barrel domain protein
LK06_RS01115	COG1595	DNA-templated transcription, initiation
LK06_RS01140	COG0667	Aldo Keto reductase
LK06_RS01175	COG2124	cytochrome p450
LK06_RS01230	COG2124	cytochrome p450
LK06_RS01230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LK06_RS01260	COG1309	transcriptional regulator
LK06_RS01295	COG0247	lactate metabolic process
LK06_RS01300	COG1139	Iron-sulfur cluster binding protein
LK06_RS01305	COG1556	Lactate utilization protein
LK06_RS01310	COG0542	response to heat
LK06_RS01340	COG1309	transcriptional regulator
LK06_RS01405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK06_RS01415	COG0076	glutamate decarboxylase activity
LK06_RS01425	COG0671	phosphoesterase, PA-phosphatase related
LK06_RS01430	COG0745	RESPONSE REGULATOR receiver
LK06_RS01435	COG2205	protein histidine kinase activity
LK06_RS01455	COG0411	ABC transporter
LK06_RS01470	COG0242	peptide deformylase activity
LK06_RS01480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK06_RS01485	COG1609	Transcriptional regulator
LK06_RS01510	COG2268	Band 7 protein
LK06_RS01535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK06_RS01540	COG0121	glutamine amidotransferase
LK06_RS01545	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LK06_RS01550	COG2182	Extracellular solute-binding protein
LK06_RS01555	COG3360	Dodecin
LK06_RS01585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LK06_RS01590	COG1053	succinate dehydrogenase
LK06_RS01645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK06_RS01645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK06_RS01655	COG0531	amino acid
LK06_RS01680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK06_RS01715	COG0395	ABC-type sugar transport system, permease component
LK06_RS01720	COG1175	transmembrane transport
LK06_RS01730	COG1609	Transcriptional regulator
LK06_RS01755	COG3537	Alpha-1,2-mannosidase
LK06_RS01775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LK06_RS01785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LK06_RS01805	COG1201	RNA secondary structure unwinding
LK06_RS01900	COG0142	geranyltranstransferase activity
LK06_RS01910	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LK06_RS01920	COG4221	oxidoreductase activity
LK06_RS01945	COG0702	epimerase
LK06_RS01950	COG1357	PFAM Pentapeptide repeats (8 copies)
LK06_RS02050	COG1132	(ABC) transporter
LK06_RS02060	COG1024	Enoyl-CoA hydratase
LK06_RS02065	COG0668	transmembrane transport
LK06_RS02070	COG2838	Isocitrate dehydrogenase
LK06_RS02075	COG2124	cytochrome p450
LK06_RS02130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK06_RS02135	COG3938	Belongs to the proline racemase family
LK06_RS02145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK06_RS02150	COG0586	Pfam SNARE associated Golgi protein
LK06_RS02170	COG1960	acyl-CoA dehydrogenase activity
LK06_RS02175	COG1960	acyl-CoA dehydrogenase activity
LK06_RS02185	COG1793	dna ligase
LK06_RS02195	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS02205	COG3424	synthase
LK06_RS02210	COG2124	cytochrome p450
LK06_RS02225	COG1960	acyl-CoA dehydrogenase activity
LK06_RS02235	COG0242	peptide deformylase activity
LK06_RS02245	COG3442	glutamine amidotransferase
LK06_RS02250	COG0205	6-phosphofructokinase activity
LK06_RS02265	COG1522	sequence-specific DNA binding
LK06_RS02270	COG1834	amidinotransferase
LK06_RS02275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK06_RS02280	COG0204	Acyl-transferase
LK06_RS02290	COG0829	nickel cation binding
LK06_RS02295	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LK06_RS02300	COG0830	nickel cation binding
LK06_RS02305	COG0804	urea catabolic process
LK06_RS02310	COG0832	Belongs to the urease beta subunit family
LK06_RS02315	COG0831	urea catabolic process
LK06_RS02330	COG0740	serine-type endopeptidase activity
LK06_RS02365	COG0156	8-amino-7-oxononanoate synthase activity
LK06_RS02370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LK06_RS02375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK06_RS02380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LK06_RS02390	COG2226	methyltransferase
LK06_RS02445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK06_RS02465	COG2124	cytochrome p450
LK06_RS02495	COG0604	alcohol dehydrogenase
LK06_RS02495	COG3321	synthase
LK06_RS02560	COG4977	sequence-specific DNA binding
LK06_RS02560	COG1917	Cupin 2, conserved barrel domain protein
LK06_RS02590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK06_RS02610	COG4977	sequence-specific DNA binding
LK06_RS02610	COG1917	Cupin 2, conserved barrel domain protein
LK06_RS02630	COG0477	Major facilitator Superfamily
LK06_RS02640	COG3251	PFAM MbtH domain protein
LK06_RS02650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS02660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK06_RS02665	COG2072	flavoprotein involved in K transport
LK06_RS02690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS02695	COG3251	PFAM MbtH domain protein
LK06_RS02715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LK06_RS02720	COG0277	FAD linked oxidase domain protein
LK06_RS02735	COG0243	molybdopterin cofactor binding
LK06_RS02740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS02755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK06_RS02760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK06_RS02770	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LK06_RS02780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS02810	COG1132	(ABC) transporter
LK06_RS02825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK06_RS02840	COG1940	carbohydrate kinase activity
LK06_RS02860	COG0596	Alpha beta hydrolase
LK06_RS02875	COG0626	cystathionine gamma-synthase activity
LK06_RS02925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK06_RS02955	COG0419	ATPase involved in DNA repair
LK06_RS02960	COG0420	3'-5' exonuclease activity
LK06_RS02965	COG1739	Uncharacterized protein family UPF0029
LK06_RS02980	COG1832	CoA-binding protein
LK06_RS02985	COG0531	amino acid
LK06_RS02990	COG0640	Transcriptional regulator
LK06_RS03005	COG0110	maltose O-acetyltransferase activity
LK06_RS03030	COG1819	glycosyl
LK06_RS03055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK06_RS03080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK06_RS03095	COG2267	carboxylic ester hydrolase activity
LK06_RS03110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LK06_RS03130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK06_RS03135	COG0747	negative chemotaxis
LK06_RS03205	COG3631	Ketosteroid isomerase-related protein
LK06_RS03210	COG0702	epimerase
LK06_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS03245	COG2124	cytochrome p450
LK06_RS03255	COG0017	Asparaginyl-tRNA synthetase
LK06_RS03260	COG0277	FAD linked oxidase domain protein
LK06_RS03265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS03280	COG2226	methyltransferase
LK06_RS03290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS03320	COG0697	spore germination
LK06_RS03540	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK06_RS03555	COG0384	phenazine biosynthesis protein PhzF
LK06_RS03610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK06_RS03610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK06_RS03620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK06_RS03640	COG1716	ATPase activity
LK06_RS03660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK06_RS03695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK06_RS03705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK06_RS03735	COG3547	Transposase (IS116 IS110 IS902 family)
LK06_RS03755	COG2018	Roadblock/LC7 domain
LK06_RS03785	COG1984	allophanate hydrolase subunit 2
LK06_RS03790	COG2755	lipolytic protein G-D-S-L family
LK06_RS03795	COG0438	transferase activity, transferring glycosyl groups
LK06_RS03800	COG0438	transferase activity, transferring glycosyl groups
LK06_RS03830	COG2364	Membrane
LK06_RS03840	COG2270	Major facilitator Superfamily
LK06_RS03850	COG3030	protein affecting phage T7 exclusion by the F plasmid
LK06_RS03855	COG1216	Glycosyl transferase, family 2
LK06_RS03880	COG1960	acyl-CoA dehydrogenase activity
LK06_RS03930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LK06_RS03935	COG0140	phosphoribosyl-ATP diphosphatase activity
LK06_RS03940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LK06_RS03945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK06_RS03945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK06_RS03950	COG3201	nicotinamide mononucleotide transporter
LK06_RS03960	COG0702	epimerase
LK06_RS03985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK06_RS04005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK06_RS04010	COG3842	ATPase activity
LK06_RS04030	COG2186	Transcriptional regulator
LK06_RS04045	COG2390	Transcriptional regulator
LK06_RS04050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LK06_RS04060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK06_RS04075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LK06_RS04090	COG0194	GDP metabolic process
LK06_RS04100	COG0284	orotidine-5'-phosphate decarboxylase activity
LK06_RS04105	COG0167	dihydroorotate dehydrogenase activity
LK06_RS04110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LK06_RS04115	COG0505	Belongs to the CarA family
LK06_RS04125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK06_RS04130	COG0540	Belongs to the ATCase OTCase family
LK06_RS04135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LK06_RS04145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK06_RS04150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK06_RS04155	COG0006	proline dipeptidase activity
LK06_RS04165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LK06_RS04170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LK06_RS04175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LK06_RS04180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LK06_RS04190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LK06_RS04195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK06_RS04210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LK06_RS04230	COG0124	histidyl-tRNA synthetase
LK06_RS04240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK06_RS04245	COG1196	nuclear chromosome segregation
LK06_RS04250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK06_RS04260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK06_RS04265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK06_RS04270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK06_RS04280	COG2255	four-way junction helicase activity
LK06_RS04285	COG0632	four-way junction helicase activity
LK06_RS04290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LK06_RS04300	COG0217	transcriptional regulatory protein
LK06_RS04305	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LK06_RS04310	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LK06_RS04320	COG0438	transferase activity, transferring glycosyl groups
LK06_RS04325	COG1560	Kdo2-lipid A biosynthetic process
LK06_RS04330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LK06_RS04350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK06_RS04355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LK06_RS04370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LK06_RS04510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LK06_RS04565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK06_RS04565	COG1648	precorrin-2 dehydrogenase activity
LK06_RS04570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LK06_RS04585	COG1464	Belongs to the NlpA lipoprotein family
LK06_RS04590	COG2011	ABC-type metal ion transport system permease component
LK06_RS04595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK06_RS04625	COG0204	Acyl-transferase
LK06_RS04625	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS04630	COG0477	Major facilitator Superfamily
LK06_RS04645	COG0165	Argininosuccinate lyase
LK06_RS04655	COG2205	protein histidine kinase activity
LK06_RS04660	COG0745	RESPONSE REGULATOR receiver
LK06_RS04690	COG1438	arginine binding
LK06_RS04695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK06_RS04700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK06_RS04705	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LK06_RS04710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LK06_RS04725	COG0463	Glycosyl transferase, family 2
LK06_RS04760	COG1649	PFAM Uncharacterised BCR, COG1649
LK06_RS04790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK06_RS04790	COG0072	phenylalanine-tRNA ligase activity
LK06_RS04795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LK06_RS04800	COG5002	protein histidine kinase activity
LK06_RS04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK06_RS04810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LK06_RS04815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LK06_RS04820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LK06_RS04865	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS04870	COG0174	glutamine synthetase
LK06_RS04875	COG2186	Transcriptional regulator
LK06_RS04880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK06_RS04895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LK06_RS04905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK06_RS04920	COG0564	pseudouridine synthase activity
LK06_RS04955	COG0805	protein transport
LK06_RS04960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK06_RS04995	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK06_RS05005	COG1609	Transcriptional regulator
LK06_RS05010	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK06_RS05015	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK06_RS05030	COG4122	O-methyltransferase activity
LK06_RS05035	COG1222	aaa ATPase
LK06_RS05060	COG0517	IMP dehydrogenase activity
LK06_RS05060	COG1994	Peptidase M50
LK06_RS05075	COG2197	response regulator
LK06_RS05080	COG0747	negative chemotaxis
LK06_RS05085	COG0747	negative chemotaxis
LK06_RS05095	COG0646	methionine synthase
LK06_RS05095	COG1410	methionine synthase
LK06_RS05100	COG1414	Transcriptional regulator
LK06_RS05105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK06_RS05110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK06_RS05115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LK06_RS05120	COG2186	Transcriptional regulator
LK06_RS05130	COG0215	cysteine-tRNA ligase activity
LK06_RS05150	COG0598	Magnesium transport protein CorA
LK06_RS05160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK06_RS05165	COG0667	Aldo Keto reductase
LK06_RS05195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK06_RS05205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LK06_RS05205	COG1796	DNA polymerase
LK06_RS05225	COG3012	SEC-C Motif Domain Protein
LK06_RS05230	COG2186	Transcriptional regulator
LK06_RS05235	COG3265	gluconokinase activity
LK06_RS05265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LK06_RS05270	COG2149	membrane
LK06_RS05295	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS05340	COG1960	acyl-CoA dehydrogenase activity
LK06_RS05350	COG0640	Transcriptional regulator
LK06_RS05355	COG0697	spore germination
LK06_RS05370	COG0243	molybdopterin cofactor binding
LK06_RS05385	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LK06_RS05390	COG2188	Transcriptional regulator
LK06_RS05415	COG1595	DNA-templated transcription, initiation
LK06_RS05440	COG2755	lipolytic protein G-D-S-L family
LK06_RS05460	COG0726	polysaccharide deacetylase
LK06_RS05485	COG1725	Transcriptional regulator
LK06_RS05500	COG2226	methyltransferase
LK06_RS05515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LK06_RS05520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK06_RS05525	COG0587	DNA-directed DNA polymerase activity
LK06_RS05545	COG0542	response to heat
LK06_RS05555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK06_RS05560	COG0587	DNA-directed DNA polymerase activity
LK06_RS05585	COG1799	cell septum assembly
LK06_RS05590	COG1960	acyl-CoA dehydrogenase activity
LK06_RS05595	COG0477	Major facilitator Superfamily
LK06_RS05610	COG0671	phosphoesterase, PA-phosphatase related
LK06_RS05620	COG3583	domain protein
LK06_RS05635	COG1160	GTP binding
LK06_RS05645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LK06_RS05665	COG3541	Predicted nucleotidyltransferase
LK06_RS05680	COG1187	pseudouridine synthase activity
LK06_RS05685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LK06_RS05690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LK06_RS05705	COG0686	Belongs to the AlaDH PNT family
LK06_RS05715	COG0494	nUDIX hydrolase
LK06_RS05720	COG0504	CTP synthase activity
LK06_RS05730	COG3387	PFAM Glycoside hydrolase 15-related
LK06_RS05755	COG0497	DNA recombination
LK06_RS05760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LK06_RS05780	COG1120	ATPase activity
LK06_RS05785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK06_RS05790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK06_RS05795	COG0647	UMP catabolic process
LK06_RS05830	COG2094	Belongs to the DNA glycosylase MPG family
LK06_RS05880	COG1881	PFAM PEBP family protein
LK06_RS05900	COG1119	ATPase activity
LK06_RS05920	COG2197	response regulator
LK06_RS05925	COG4585	Histidine kinase
LK06_RS05935	COG1131	(ABC) transporter
LK06_RS05935	COG0842	Transport permease protein
LK06_RS05935	COG1716	ATPase activity
LK06_RS05945	COG0560	Phosphoserine phosphatase
LK06_RS05945	COG3830	Belongs to the UPF0237 family
LK06_RS05950	COG0588	phosphoglycerate mutase activity
LK06_RS05965	COG2807	transmembrane transport
LK06_RS05970	COG2186	Transcriptional regulator
LK06_RS06030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LK06_RS06050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LK06_RS06055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK06_RS06075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK06_RS06080	COG1063	alcohol dehydrogenase
LK06_RS06120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK06_RS06135	COG3387	PFAM Glycoside hydrolase 15-related
LK06_RS06170	COG1302	Protein conserved in bacteria
LK06_RS06180	COG1024	Enoyl-CoA hydratase
LK06_RS06190	COG0488	(ABC) transporter
LK06_RS06210	COG0235	Class ii aldolase
LK06_RS06235	COG1492	cobalamin metabolic process
LK06_RS06250	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LK06_RS06255	COG1797	cobyrinic acid a,c-diamide synthase activity
LK06_RS06315	COG0765	amino acid transport
LK06_RS06325	COG0456	acetyltransferase
LK06_RS06330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK06_RS06335	COG1917	Cupin 2, conserved barrel domain protein
LK06_RS06340	COG5285	phytanoyl-CoA dioxygenase
LK06_RS06365	COG1414	Transcriptional regulator
LK06_RS06395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK06_RS06430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK06_RS06435	COG2171	N-acyltransferase activity
LK06_RS06440	COG2076	Multidrug Resistance protein
LK06_RS06450	COG2151	metal-sulfur cluster biosynthetic enzyme
LK06_RS06455	COG0822	iron-sulfur transferase activity
LK06_RS06460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK06_RS06465	COG0396	ATPase activity
LK06_RS06475	COG0719	Fe-S assembly protein
LK06_RS06490	COG2746	aminoglycoside 3-N-acetyltransferase activity
LK06_RS06495	COG1131	(ABC) transporter
LK06_RS06505	COG1612	heme a metabolic process
LK06_RS06525	COG0109	protoheme IX farnesyltransferase activity
LK06_RS06535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK06_RS06540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK06_RS06555	COG0363	glucosamine-6-phosphate deaminase activity
LK06_RS06560	COG0395	ABC-type sugar transport system, permease component
LK06_RS06565	COG1175	transmembrane transport
LK06_RS06570	COG1653	transport
LK06_RS06575	COG0366	Alpha amylase catalytic
LK06_RS06580	COG1653	transport
LK06_RS06585	COG1695	Transcriptional regulator
LK06_RS06590	COG0577	efflux transmembrane transporter activity
LK06_RS06590	COG1136	(ABC) transporter
LK06_RS06600	COG0166	Belongs to the GPI family
LK06_RS06610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK06_RS06615	COG0149	triose-phosphate isomerase activity
LK06_RS06620	COG0126	phosphoglycerate kinase activity
LK06_RS06625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK06_RS06630	COG1481	regulation of sporulation
LK06_RS06635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK06_RS06640	COG1660	Displays ATPase and GTPase activities
LK06_RS06645	COG0322	excinuclease ABC activity
LK06_RS06660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK06_RS06665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK06_RS06680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LK06_RS06690	COG0387	Pfam Sodium calcium exchanger
LK06_RS06705	COG0556	nucleotide-excision repair
LK06_RS06715	COG0584	glycerophosphoryl diester phosphodiesterase
LK06_RS06720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK06_RS06730	COG2313	pseudouridylate synthase activity
LK06_RS06735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LK06_RS06735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LK06_RS06740	COG2226	methyltransferase
LK06_RS06745	COG0598	Magnesium transport protein CorA
LK06_RS06815	COG1289	transmembrane transporter activity
LK06_RS06840	COG0237	dephospho-CoA kinase activity
LK06_RS06850	COG0539	negative regulation of cytoplasmic translation
LK06_RS06860	COG1643	Atp-dependent helicase
LK06_RS06895	COG2050	protein possibly involved in aromatic compounds catabolism
LK06_RS06900	COG0683	leucine binding
LK06_RS06960	COG1605	Chorismate mutase
LK06_RS06960	COG0287	Prephenate dehydrogenase
LK06_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS06985	COG1024	Enoyl-CoA hydratase
LK06_RS07005	COG0183	Belongs to the thiolase family
LK06_RS07010	COG1309	transcriptional regulator
LK06_RS07015	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS07020	COG1960	acyl-CoA dehydrogenase activity
LK06_RS07030	COG2304	oxidoreductase activity
LK06_RS07040	COG0067	glutamate synthase
LK06_RS07040	COG0070	glutamate synthase
LK06_RS07040	COG0069	glutamate synthase activity
LK06_RS07050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK06_RS07055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LK06_RS07065	COG0159	tryptophan synthase activity
LK06_RS07070	COG0133	tryptophan synthase activity
LK06_RS07080	COG0134	indole-3-glycerol-phosphate synthase activity
LK06_RS07110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LK06_RS07120	COG0346	lactoylglutathione lyase activity
LK06_RS07125	COG0107	imidazoleglycerol-phosphate synthase activity
LK06_RS07130	COG0251	oxidation-reduction process
LK06_RS07135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LK06_RS07140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LK06_RS07145	COG0131	Imidazoleglycerol-phosphate dehydratase
LK06_RS07150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK06_RS07155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LK06_RS07170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK06_RS07190	COG1432	Conserved Protein
LK06_RS07195	COG0587	DNA-directed DNA polymerase activity
LK06_RS07245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LK06_RS07260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LK06_RS07265	COG3599	regulation of cell shape
LK06_RS07275	COG1799	cell septum assembly
LK06_RS07285	COG1496	oxidoreductase activity
LK06_RS07290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LK06_RS07300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK06_RS07310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LK06_RS07315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK06_RS07320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LK06_RS07325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LK06_RS07340	COG0275	rRNA processing
LK06_RS07350	COG0714	Associated with various cellular activities
LK06_RS07370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK06_RS07385	COG1511	domain protein
LK06_RS07390	COG1309	transcriptional regulator
LK06_RS07410	COG0352	thiamine-phosphate diphosphorylase activity
LK06_RS07420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK06_RS07430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK06_RS07430	COG2022	thiamine diphosphate biosynthetic process
LK06_RS07440	COG2022	thiamine diphosphate biosynthetic process
LK06_RS07445	COG2815	serine threonine protein kinase
LK06_RS07445	COG0515	serine threonine protein kinase
LK06_RS07450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LK06_RS07455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LK06_RS07460	COG2193	ferroxidase activity
LK06_RS07465	COG0243	molybdopterin cofactor binding
LK06_RS07470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LK06_RS07480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LK06_RS07485	COG0205	6-phosphofructokinase activity
LK06_RS07495	COG4585	Histidine kinase
LK06_RS07525	COG1940	carbohydrate kinase activity
LK06_RS07535	COG0003	Pfam Anion-transporting ATPase
LK06_RS07560	COG0438	transferase activity, transferring glycosyl groups
LK06_RS07575	COG0791	NLP P60 protein
LK06_RS07575	COG3883	PFAM NLP P60 protein
LK06_RS07605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK06_RS07610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK06_RS07615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LK06_RS07620	COG0723	plastoquinol--plastocyanin reductase activity
LK06_RS07625	COG2010	Cytochrome c
LK06_RS07630	COG1845	cytochrome c oxidase, subunit III
LK06_RS07640	COG1376	ErfK ybiS ycfS ynhG family protein
LK06_RS07650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK06_RS07655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LK06_RS07665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK06_RS07695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LK06_RS07700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK06_RS07705	COG2197	response regulator
LK06_RS07710	COG4585	Histidine kinase
LK06_RS07750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LK06_RS07755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK06_RS07755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK06_RS07770	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LK06_RS07780	COG0438	transferase activity, transferring glycosyl groups
LK06_RS07790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LK06_RS07795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK06_RS07800	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK06_RS07810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LK06_RS07855	COG0321	lipoyl(octanoyl) transferase activity
LK06_RS07860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LK06_RS07900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK06_RS07905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK06_RS07920	COG2329	Antibiotic biosynthesis monooxygenase
LK06_RS07935	COG0174	glutamine synthetase
LK06_RS07945	COG2226	methyltransferase
LK06_RS07960	COG0477	Major facilitator Superfamily
LK06_RS07995	COG2124	cytochrome p450
LK06_RS08000	COG0501	Belongs to the peptidase M48B family
LK06_RS08080	COG1309	transcriptional regulator
LK06_RS08100	COG0366	Alpha amylase catalytic
LK06_RS08105	COG3833	ABC-type maltose transport systems, permease component
LK06_RS08110	COG1175	transmembrane transport
LK06_RS08120	COG1609	Transcriptional regulator
LK06_RS08130	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LK06_RS08135	COG3511	phospholipase C
LK06_RS08140	COG0174	glutamine synthetase
LK06_RS08150	COG1959	2 iron, 2 sulfur cluster binding
LK06_RS08170	COG2814	Major facilitator Superfamily
LK06_RS08220	COG0477	Major facilitator Superfamily
LK06_RS08225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LK06_RS08245	COG1994	Peptidase M50
LK06_RS08290	COG2822	iron ion transport
LK06_RS08295	COG2837	iron assimilation
LK06_RS08300	COG0672	)-iron permease
LK06_RS08320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK06_RS08325	COG2814	Major facilitator Superfamily
LK06_RS08335	COG1686	Belongs to the peptidase S11 family
LK06_RS08355	COG1404	Belongs to the peptidase S8 family
LK06_RS08410	COG3022	response to hydroperoxide
LK06_RS08415	COG0800	Aldolase
LK06_RS08430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LK06_RS08455	COG2030	dehydratase
LK06_RS08460	COG4585	Histidine kinase
LK06_RS08465	COG2197	response regulator
LK06_RS08470	COG0183	Belongs to the thiolase family
LK06_RS08480	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK06_RS08490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK06_RS08505	COG0438	transferase activity, transferring glycosyl groups
LK06_RS08510	COG1309	transcriptional regulator
LK06_RS08590	COG3845	ABC transporter
LK06_RS08605	COG3619	membrane
LK06_RS08610	COG2124	cytochrome p450
LK06_RS08615	COG0183	Belongs to the thiolase family
LK06_RS08625	COG4122	O-methyltransferase activity
LK06_RS08650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK06_RS08670	COG0483	inositol monophosphate 1-phosphatase activity
LK06_RS08735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK06_RS08750	COG1358	cellular component organization or biogenesis
LK06_RS08795	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LK06_RS08800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LK06_RS08805	COG0477	Major facilitator Superfamily
LK06_RS08810	COG1309	transcriptional regulator
LK06_RS08825	COG0789	Transcriptional regulator
LK06_RS08840	COG1741	Belongs to the pirin family
LK06_RS08855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK06_RS08860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK06_RS08865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK06_RS08890	COG2130	NADP-dependent
LK06_RS08895	COG1764	response to oxidative stress
LK06_RS08905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK06_RS08950	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS08955	COG0825	malonyl-CoA metabolic process
LK06_RS08955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LK06_RS08960	COG1077	Cell shape determining protein MreB Mrl
LK06_RS08975	COG4213	ABC transporter substrate-binding protein
LK06_RS09155	COG1070	Carbohydrate kinase
LK06_RS09170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK06_RS09180	COG0358	DNA primase activity
LK06_RS09190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LK06_RS09205	COG0243	molybdopterin cofactor binding
LK06_RS09225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK06_RS09230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK06_RS09230	COG2146	nitrite reductase [NAD(P)H] activity
LK06_RS09245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK06_RS09245	COG0574	Belongs to the PEP-utilizing enzyme family
LK06_RS09250	COG1940	carbohydrate kinase activity
LK06_RS09250	COG1846	Transcriptional regulator
LK06_RS09255	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LK06_RS09285	COG3547	Transposase (IS116 IS110 IS902 family)
LK06_RS09290	COG0423	glycine-tRNA ligase activity
LK06_RS09295	COG0803	Belongs to the bacterial solute-binding protein 9 family
LK06_RS09295	COG3443	Belongs to the bacterial solute-binding protein 9 family
LK06_RS09300	COG1121	(ABC) transporter
LK06_RS09305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LK06_RS09315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK06_RS09320	COG1381	Involved in DNA repair and RecF pathway recombination
LK06_RS09335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK06_RS09345	COG1136	(ABC) transporter
LK06_RS09355	COG4585	Histidine kinase
LK06_RS09360	COG2197	response regulator
LK06_RS09370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK06_RS09395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LK06_RS09430	COG1619	proteins homologs of microcin C7 resistance protein MccF
LK06_RS09435	COG2315	Protein conserved in bacteria
LK06_RS09445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LK06_RS09455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK06_RS09465	COG1234	tRNA 3'-trailer cleavage
LK06_RS09470	COG0537	adenosine 5'-monophosphoramidase activity
LK06_RS09475	COG0793	Belongs to the peptidase S41A family
LK06_RS09475	COG4946	Tricorn protease homolog
LK06_RS09495	COG0484	heat shock protein binding
LK06_RS09500	COG1420	regulation of RNA biosynthetic process
LK06_RS09530	COG0481	GTPase activity
LK06_RS09535	COG0268	Binds directly to 16S ribosomal RNA
LK06_RS09560	COG1596	polysaccharide export
LK06_RS09560	COG1555	photosystem II stabilization
LK06_RS09565	COG1307	EDD domain protein, DegV family
LK06_RS09575	COG0495	leucyl-tRNA aminoacylation
LK06_RS09585	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LK06_RS09605	COG0588	phosphoglycerate mutase activity
LK06_RS09620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LK06_RS09635	COG0501	Belongs to the peptidase M48B family
LK06_RS09650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LK06_RS09665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LK06_RS09690	COG3328	transposase activity
LK06_RS09730	COG0582	viral genome integration into host DNA
LK06_RS09775	COG4974	Belongs to the 'phage' integrase family
LK06_RS09800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LK06_RS09805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LK06_RS09810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LK06_RS09815	COG0371	Dehydrogenase
LK06_RS09825	COG1530	ribonuclease E activity
LK06_RS09855	COG0772	Belongs to the SEDS family
LK06_RS09860	COG0768	penicillin binding
LK06_RS09875	COG1077	Cell shape determining protein MreB Mrl
LK06_RS09880	COG0105	UTP biosynthetic process
LK06_RS09890	COG0285	dihydrofolate synthase activity
LK06_RS09895	COG0525	valine-tRNA ligase activity
LK06_RS09905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LK06_RS09910	COG0740	serine-type endopeptidase activity
LK06_RS09915	COG0740	serine-type endopeptidase activity
LK06_RS09920	COG0544	peptidyl-prolyl cis-trans isomerase activity
LK06_RS09940	COG3594	Acyltransferase
LK06_RS09960	COG4552	Acetyltransferase involved in intracellular survival and related
LK06_RS09980	COG1113	amino acid transport
LK06_RS09990	COG1113	amino acid transport
LK06_RS09995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LK06_RS10000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK06_RS10045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK06_RS10075	COG1595	DNA-templated transcription, initiation
LK06_RS10085	COG1131	(ABC) transporter
LK06_RS10105	COG0668	transmembrane transport
LK06_RS10120	COG1175	transmembrane transport
LK06_RS10125	COG0395	ABC-type sugar transport system, permease component
LK06_RS10130	COG1486	melibiose metabolic process
LK06_RS10145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK06_RS10175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LK06_RS10215	COG0629	single-stranded DNA binding
LK06_RS10270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK06_RS10275	COG0438	transferase activity, transferring glycosyl groups
LK06_RS10340	COG0438	transferase activity, transferring glycosyl groups
LK06_RS10365	COG0438	transferase activity, transferring glycosyl groups
LK06_RS10390	COG0492	ferredoxin-NADP+ reductase activity
LK06_RS10425	COG1131	(ABC) transporter
LK06_RS10445	COG3962	Belongs to the TPP enzyme family
LK06_RS10450	COG3718	enzyme involved in inositol metabolism
LK06_RS10460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK06_RS10520	COG0582	viral genome integration into host DNA
LK06_RS10550	COG2188	Transcriptional regulator
LK06_RS10615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LK06_RS10645	COG1472	Belongs to the glycosyl hydrolase 3 family
LK06_RS10675	COG0028	Belongs to the TPP enzyme family
LK06_RS10700	COG1946	Acyl-CoA thioesterase
LK06_RS10710	COG1309	transcriptional regulator
LK06_RS10715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK06_RS10725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK06_RS10730	COG1960	acyl-CoA dehydrogenase activity
LK06_RS10750	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LK06_RS10770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK06_RS10780	COG0589	response to stress
LK06_RS10795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LK06_RS10830	COG3979	chitinase
LK06_RS10840	COG0745	RESPONSE REGULATOR receiver
LK06_RS10850	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LK06_RS10865	COG0406	alpha-ribazole phosphatase activity
LK06_RS10915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK06_RS10935	COG0154	amidase activity
LK06_RS10945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK06_RS10950	COG0765	amino acid transport
LK06_RS10955	COG0765	amino acid transport
LK06_RS10960	COG1126	abc transporter atp-binding protein
LK06_RS10975	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS11020	COG2188	Transcriptional regulator
LK06_RS11035	COG0673	inositol 2-dehydrogenase activity
LK06_RS11040	COG4702	Belongs to the UPF0303 family
LK06_RS11055	COG0706	membrane insertase activity
LK06_RS11065	COG1309	transcriptional regulator
LK06_RS11070	COG1136	(ABC) transporter
LK06_RS11095	COG2733	membrane
LK06_RS11105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LK06_RS11130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK06_RS11160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LK06_RS11165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK06_RS11170	COG1263	PTS System
LK06_RS11175	COG1263	PTS System
LK06_RS11185	COG0463	Glycosyl transferase, family 2
LK06_RS11190	COG1234	tRNA 3'-trailer cleavage
LK06_RS11230	COG1113	amino acid transport
LK06_RS11245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LK06_RS11255	COG1335	isochorismatase
LK06_RS11290	COG0277	FAD linked oxidase domain protein
LK06_RS11300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LK06_RS11310	COG1174	glycine betaine transport
LK06_RS11315	COG0517	IMP dehydrogenase activity
LK06_RS11315	COG1125	glycine betaine transport
LK06_RS11320	COG1174	glycine betaine transport
LK06_RS11340	COG3480	Lon protease (S16) C-terminal proteolytic domain
LK06_RS11410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LK06_RS11420	COG1678	Uncharacterized ACR, COG1678
LK06_RS11425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK06_RS11435	COG0776	regulation of translation
LK06_RS11445	COG3973	AAA domain
LK06_RS11465	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LK06_RS11470	COG1366	Belongs to the anti-sigma-factor antagonist family
LK06_RS11475	COG1366	Belongs to the anti-sigma-factor antagonist family
LK06_RS11515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK06_RS11535	COG2223	nitrite transmembrane transporter activity
LK06_RS11545	COG0583	DNA-binding transcription factor activity
LK06_RS11565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LK06_RS11570	COG0793	Belongs to the peptidase S41A family
LK06_RS11575	COG2177	Part of the ABC transporter FtsEX involved in
LK06_RS11580	COG2884	Cell division ATP-binding protein ftsE
LK06_RS11595	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LK06_RS11600	COG0515	serine threonine protein kinase
LK06_RS11605	COG0515	serine threonine protein kinase
LK06_RS11620	COG1175	transmembrane transport
LK06_RS11625	COG0395	ABC-type sugar transport system, permease component
LK06_RS11630	COG1216	Glycosyl transferase, family 2
LK06_RS11635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LK06_RS11640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LK06_RS11645	COG1764	response to oxidative stress
LK06_RS11650	COG1846	Transcriptional regulator
LK06_RS11685	COG1134	teichoic acid transport
LK06_RS11685	COG1388	LysM domain
LK06_RS11690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LK06_RS11695	COG1215	transferase activity, transferring glycosyl groups
LK06_RS11705	COG2902	Dehydrogenase
LK06_RS11730	COG0653	protein targeting
LK06_RS11740	COG3214	Protein conserved in bacteria
LK06_RS11745	COG2197	response regulator
LK06_RS11750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LK06_RS11760	COG0823	Involved in the tonB-independent uptake of proteins
LK06_RS11765	COG5000	phosphorelay sensor kinase activity
LK06_RS11765	COG5002	protein histidine kinase activity
LK06_RS11770	COG0745	RESPONSE REGULATOR receiver
LK06_RS11775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LK06_RS11795	COG0714	Associated with various cellular activities
LK06_RS11840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LK06_RS11855	COG1482	cell wall glycoprotein biosynthetic process
LK06_RS11865	COG2835	tetraacyldisaccharide 4'-kinase activity
LK06_RS11870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK06_RS11910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK06_RS11915	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LK06_RS11915	COG0778	Nitroreductase
LK06_RS11940	COG1316	TRANSCRIPTIONal
LK06_RS11945	COG1316	TRANSCRIPTIONal
LK06_RS11955	COG1316	TRANSCRIPTIONal
LK06_RS11965	COG1316	TRANSCRIPTIONal
LK06_RS11990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LK06_RS12030	COG2205	protein histidine kinase activity
LK06_RS12035	COG0745	RESPONSE REGULATOR receiver
LK06_RS12040	COG3104	oligopeptide transport
LK06_RS12060	COG1366	Belongs to the anti-sigma-factor antagonist family
LK06_RS12065	COG1191	sigma factor activity
LK06_RS12075	COG1228	amidohydrolase
LK06_RS12085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK06_RS12090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LK06_RS12135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK06_RS12140	COG1072	(Pantothenic acid kinase))
LK06_RS12145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK06_RS12150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LK06_RS12155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LK06_RS12165	COG0101	tRNA pseudouridine synthase activity
LK06_RS12170	COG0203	ribosomal protein L17
LK06_RS12175	COG0202	RNA polymerase activity
LK06_RS12180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LK06_RS12185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LK06_RS12190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK06_RS12195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK06_RS12205	COG0563	adenylate kinase activity
LK06_RS12215	COG0200	Binds to the 23S rRNA
LK06_RS12220	COG1841	ribosomal large subunit assembly
LK06_RS12225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LK06_RS12230	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LK06_RS12235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LK06_RS12240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LK06_RS12250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LK06_RS12255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LK06_RS12260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LK06_RS12265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LK06_RS12270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LK06_RS12275	COG0255	Belongs to the universal ribosomal protein uL29 family
LK06_RS12280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LK06_RS12285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LK06_RS12290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LK06_RS12295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LK06_RS12300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LK06_RS12305	COG0089	rRNA binding
LK06_RS12310	COG0088	Forms part of the polypeptide exit tunnel
LK06_RS12315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LK06_RS12320	COG0051	transcription antitermination factor activity, RNA binding
LK06_RS12340	COG2885	chlorophyll binding
LK06_RS12385	COG1115	amino acid carrier protein
LK06_RS12390	COG3835	regulator
LK06_RS12405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK06_RS12410	COG0049	tRNA binding
LK06_RS12415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LK06_RS12420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LK06_RS12425	COG0085	RNA polymerase activity
LK06_RS12450	COG0081	regulation of translation
LK06_RS12455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LK06_RS12460	COG0250	Participates in transcription elongation, termination and antitermination
LK06_RS12475	COG0436	Aminotransferase
LK06_RS12480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK06_RS12490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LK06_RS12510	COG2030	dehydratase
LK06_RS12515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LK06_RS12535	COG0702	epimerase
LK06_RS12580	COG2318	DinB family
LK06_RS12595	COG1666	GTP binding
LK06_RS12600	COG4974	Belongs to the 'phage' integrase family
LK06_RS12610	COG3547	Transposase (IS116 IS110 IS902 family)
LK06_RS12615	COG2261	transglycosylase associated protein
LK06_RS12625	COG3304	Inner membrane component domain
LK06_RS12630	COG0501	Belongs to the peptidase M48B family
LK06_RS12635	COG1007	ATP synthesis coupled electron transport
LK06_RS12640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12650	COG0713	ATP synthesis coupled electron transport
LK06_RS12655	COG0839	Belongs to the complex I subunit 6 family
LK06_RS12660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LK06_RS12670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12700	COG0674	pyruvate-flavodoxin oxidoreductase activity
LK06_RS12700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LK06_RS12705	COG1013	pyruvate-flavodoxin oxidoreductase activity
LK06_RS12710	COG1733	regulation of RNA biosynthetic process
LK06_RS12715	COG0702	epimerase
LK06_RS12735	COG1131	(ABC) transporter
LK06_RS12745	COG0142	geranyltranstransferase activity
LK06_RS12750	COG5280	Phage tail tape measure protein TP901
LK06_RS12750	COG3953	SLT domain
LK06_RS12755	COG0561	phosphatase activity
LK06_RS12775	COG1131	(ABC) transporter
LK06_RS12785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LK06_RS12790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS12825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK06_RS12830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK06_RS12845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK06_RS12860	COG2814	Major facilitator Superfamily
LK06_RS12875	COG3903	Transcriptional regulator
LK06_RS12875	COG3629	intracellular signal transduction
LK06_RS12885	COG0514	ATP-dependent DNA helicase (RecQ)
LK06_RS12890	COG1007	ATP synthesis coupled electron transport
LK06_RS12900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LK06_RS12905	COG0713	ATP synthesis coupled electron transport
LK06_RS12910	COG0839	Belongs to the complex I subunit 6 family
LK06_RS12915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LK06_RS12925	COG1034	ATP synthesis coupled electron transport
LK06_RS12930	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LK06_RS12940	COG0649	NAD binding
LK06_RS12945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK06_RS12980	COG2226	methyltransferase
LK06_RS12990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LK06_RS13010	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LK06_RS13015	COG1278	Cold shock
LK06_RS13050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LK06_RS13060	COG0163	prenyltransferase activity
LK06_RS13065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LK06_RS13070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LK06_RS13095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK06_RS13100	COG1333	cytochrome c biogenesis protein
LK06_RS13110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK06_RS13120	COG0406	alpha-ribazole phosphatase activity
LK06_RS13125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK06_RS13140	COG0582	viral genome integration into host DNA
LK06_RS13180	COG0242	peptide deformylase activity
LK06_RS13185	COG2045	Belongs to the ComB family
LK06_RS13210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LK06_RS13225	COG0640	Transcriptional regulator
LK06_RS13230	COG2072	flavoprotein involved in K transport
LK06_RS13235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK06_RS13245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK06_RS13265	COG0697	spore germination
LK06_RS13285	COG2362	D-Aminopeptidase
LK06_RS13295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK06_RS13295	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK06_RS13300	COG2205	protein histidine kinase activity
LK06_RS13315	COG1742	UPF0060 membrane protein
LK06_RS13330	COG1690	Belongs to the RtcB family
LK06_RS13350	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LK06_RS13355	COG0018	arginyl-trna synthetase
LK06_RS13360	COG0583	DNA-binding transcription factor activity
LK06_RS13390	COG3152	Membrane
LK06_RS13395	COG0113	porphobilinogen synthase activity
LK06_RS13415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK06_RS13415	COG1648	precorrin-2 dehydrogenase activity
LK06_RS13420	COG0181	hydroxymethylbilane synthase activity
LK06_RS13425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LK06_RS13430	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LK06_RS13480	COG0123	including yeast histone deacetylase and acetoin utilization protein
LK06_RS13495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK06_RS13520	COG0180	Tryptophanyl-tRNA synthetase
LK06_RS13525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LK06_RS13535	COG0842	Transport permease protein
LK06_RS13535	COG1129	ABC transporter
LK06_RS13550	COG4991	sh3 domain protein
LK06_RS13555	COG0515	serine threonine protein kinase
LK06_RS13555	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK06_RS13560	COG0129	dihydroxy-acid dehydratase activity
LK06_RS13565	COG1309	transcriptional regulator
LK06_RS13570	COG1082	Xylose isomerase domain protein TIM barrel
LK06_RS13575	COG0248	Ppx GppA phosphatase
LK06_RS13595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LK06_RS13605	COG1194	a g-specific adenine glycosylase
LK06_RS13610	COG1595	DNA-templated transcription, initiation
LK06_RS13620	COG0745	RESPONSE REGULATOR receiver
LK06_RS13625	COG2205	protein histidine kinase activity
LK06_RS13640	COG0739	heme binding
LK06_RS13670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LK06_RS13690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LK06_RS13700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LK06_RS13705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LK06_RS13715	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LK06_RS13720	COG2197	response regulator
LK06_RS13740	COG0649	NAD binding
LK06_RS13765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK06_RS13765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK06_RS13780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LK06_RS13795	COG0302	gtp cyclohydrolase
LK06_RS13810	COG0037	tRNA processing
LK06_RS13820	COG2027	D-alanyl-D-alanine carboxypeptidase
LK06_RS13825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LK06_RS13840	COG0393	Putative heavy-metal-binding
LK06_RS13845	COG0789	Transcriptional regulator
LK06_RS13850	COG0076	glutamate decarboxylase activity
LK06_RS13855	COG2318	DinB family
LK06_RS13865	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS13905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK06_RS13905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK06_RS13910	COG3629	intracellular signal transduction
LK06_RS13910	COG3903	Transcriptional regulator
LK06_RS13920	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LK06_RS13930	COG2205	protein histidine kinase activity
LK06_RS13935	COG0745	RESPONSE REGULATOR receiver
LK06_RS13945	COG0577	efflux transmembrane transporter activity
LK06_RS13945	COG1136	(ABC) transporter
LK06_RS13950	COG1136	(ABC) transporter
LK06_RS13950	COG0577	efflux transmembrane transporter activity
LK06_RS13985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LK06_RS13990	COG1754	DNA topoisomerase type I activity
LK06_RS13990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LK06_RS14000	COG2890	protein-(glutamine-N5) methyltransferase activity
LK06_RS14010	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LK06_RS14020	COG1366	Belongs to the anti-sigma-factor antagonist family
LK06_RS14025	COG1111	helicase
LK06_RS14025	COG1205	dead DEAH box helicase
LK06_RS14085	COG0659	secondary active sulfate transmembrane transporter activity
LK06_RS14090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK06_RS14105	COG2267	carboxylic ester hydrolase activity
LK06_RS14140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK06_RS14165	COG0003	Pfam Anion-transporting ATPase
LK06_RS14190	COG1408	metallophosphoesterase
LK06_RS14225	COG3209	COG3209 Rhs family protein
LK06_RS14225	COG4104	PAAR repeat-containing protein
LK06_RS14235	COG1609	Transcriptional regulator
LK06_RS14310	COG3547	Transposase (IS116 IS110 IS902 family)
LK06_RS14340	COG2095	MarC family integral membrane protein
LK06_RS14350	COG0745	RESPONSE REGULATOR receiver
LK06_RS14355	COG2205	protein histidine kinase activity
LK06_RS14365	COG1477	protein flavinylation
LK06_RS14375	COG4656	Part of a membrane complex involved in electron transport
LK06_RS14400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK06_RS14400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK06_RS14415	COG1937	Protein conserved in bacteria
LK06_RS14420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK06_RS14425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK06_RS14440	COG0477	Major facilitator Superfamily
LK06_RS14460	COG0701	Predicted permease
LK06_RS14480	COG1595	DNA-templated transcription, initiation
LK06_RS14500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LK06_RS14505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LK06_RS14515	COG0515	serine threonine protein kinase
LK06_RS14515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK06_RS14520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK06_RS14525	COG1802	Transcriptional regulator
LK06_RS14540	COG0737	Belongs to the 5'-nucleotidase family
LK06_RS14545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LK06_RS14560	COG1131	(ABC) transporter
LK06_RS14565	COG3559	Exporter of polyketide antibiotics
LK06_RS14595	COG3844	kynureninase activity
LK06_RS14600	COG3483	tryptophan 2,3-dioxygenase activity
LK06_RS14610	COG0191	fructose-bisphosphate aldolase activity
LK06_RS14615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LK06_RS14630	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LK06_RS14710	COG0542	response to heat
LK06_RS14735	COG4213	ABC transporter substrate-binding protein
LK06_RS14745	COG0789	Transcriptional regulator
LK06_RS14750	COG0484	heat shock protein binding
LK06_RS14755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LK06_RS14760	COG0443	Heat shock 70 kDa protein
LK06_RS14765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK06_RS14770	COG2181	nitrate reductase activity
LK06_RS14770	COG0247	lactate metabolic process
LK06_RS14790	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LK06_RS14795	COG0717	Belongs to the dCTP deaminase family
LK06_RS14855	COG4566	intracellular signal transduction
LK06_RS14860	COG1592	Rubrerythrin
LK06_RS14865	COG1309	transcriptional regulator
LK06_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS14880	COG1278	Cold shock
LK06_RS14885	COG0513	Belongs to the DEAD box helicase family
LK06_RS14895	COG2205	protein histidine kinase activity
LK06_RS14900	COG0745	RESPONSE REGULATOR receiver
LK06_RS14910	COG2124	cytochrome p450
LK06_RS14940	COG1252	NADH dehydrogenase
LK06_RS14945	COG1595	DNA-templated transcription, initiation
LK06_RS14960	COG2226	methyltransferase
LK06_RS15015	COG3261	NADH dehydrogenase
LK06_RS15015	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LK06_RS15020	COG0651	ATP synthesis coupled electron transport
LK06_RS15030	COG0650	Formate hydrogenlyase subunit 4
LK06_RS15040	COG3260	NADH ubiquinone oxidoreductase 20
LK06_RS15050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK06_RS15090	COG1309	transcriptional regulator
LK06_RS15095	COG1129	ABC transporter
LK06_RS15095	COG0842	Transport permease protein
LK06_RS15115	COG1595	DNA-templated transcription, initiation
LK06_RS15135	COG2208	phosphoserine phosphatase activity
LK06_RS15165	COG2255	four-way junction helicase activity
LK06_RS15185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK06_RS15205	COG0366	Alpha amylase catalytic
LK06_RS15215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LK06_RS15265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK06_RS15280	COG1289	transmembrane transporter activity
LK06_RS15290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK06_RS15300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LK06_RS15315	COG1741	Belongs to the pirin family
LK06_RS15325	COG1960	acyl-CoA dehydrogenase activity
LK06_RS15330	COG1362	aminopeptidase activity
LK06_RS15355	COG2814	Major facilitator Superfamily
LK06_RS15375	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK06_RS15380	COG0022	dehydrogenase e1 component
LK06_RS15400	COG0515	serine threonine protein kinase
LK06_RS15405	COG0515	serine threonine protein kinase
LK06_RS15420	COG0604	alcohol dehydrogenase
LK06_RS15420	COG3321	synthase
LK06_RS15420	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS15425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK06_RS15455	COG1522	sequence-specific DNA binding
LK06_RS15460	COG1309	transcriptional regulator
LK06_RS15465	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK06_RS15490	COG3396	Phenylacetate-CoA oxygenase
LK06_RS15495	COG3460	Phenylacetate-CoA oxygenase
LK06_RS15500	COG3396	Phenylacetate-CoA oxygenase
LK06_RS15505	COG2151	metal-sulfur cluster biosynthetic enzyme
LK06_RS15510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK06_RS15560	COG1716	ATPase activity
LK06_RS15565	COG1716	ATPase activity
LK06_RS15580	COG0768	penicillin binding
LK06_RS15590	COG0515	serine threonine protein kinase
LK06_RS15595	COG3764	Sortase (surface protein transpeptidase)
LK06_RS15600	COG3764	Sortase (surface protein transpeptidase)
LK06_RS15615	COG3764	Sortase (surface protein transpeptidase)
LK06_RS15630	COG0705	Rhomboid family
LK06_RS15690	COG0515	serine threonine protein kinase
LK06_RS15730	COG4249	Peptidase C14 caspase catalytic subunit p20
LK06_RS15730	COG2319	Wd-40 repeat
LK06_RS15750	COG2188	Transcriptional regulator
LK06_RS15810	COG0582	viral genome integration into host DNA
LK06_RS15825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK06_RS15830	COG0187	DNA topoisomerase II activity
LK06_RS15835	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LK06_RS15840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LK06_RS15845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LK06_RS15850	COG0592	DNA-directed DNA polymerase activity
LK06_RS15860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK06_RS15865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LK06_RS15870	COG0594	ribonuclease P activity
LK06_RS15875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LK06_RS15880	COG0706	membrane insertase activity
LK06_RS15890	COG0357	Ribosomal RNA small subunit methyltransferase G
LK06_RS15895	COG1192	Involved in chromosome partitioning
LK06_RS15910	COG3118	belongs to the thioredoxin family
LK06_RS15915	COG0492	ferredoxin-NADP+ reductase activity
LK06_RS15925	COG1595	DNA-templated transcription, initiation
LK06_RS15930	COG0515	serine threonine protein kinase
LK06_RS15930	COG2815	serine threonine protein kinase
LK06_RS15945	COG0617	tRNA 3'-terminal CCA addition
LK06_RS15965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK06_RS15990	COG0360	Binds together with S18 to 16S ribosomal RNA
LK06_RS15995	COG0629	single-stranded DNA binding
LK06_RS16000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LK06_RS16005	COG0359	binds to the 23S rRNA
LK06_RS16015	COG0305	Participates in initiation and elongation during chromosome replication
LK06_RS16065	COG0626	cystathionine gamma-synthase activity
LK06_RS16070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK06_RS16075	COG1950	PFAM Membrane protein of
LK06_RS16080	COG0662	Cupin 2, conserved barrel domain protein
LK06_RS16105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LK06_RS16120	COG1609	Transcriptional regulator
LK06_RS16125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK06_RS16135	COG1271	oxidase subunit
LK06_RS16140	COG1294	oxidase, subunit
LK06_RS16145	COG4988	ABC transporter
LK06_RS16150	COG0561	phosphatase activity
LK06_RS16165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK06_RS16185	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LK06_RS16200	COG1131	(ABC) transporter
LK06_RS16210	COG1131	(ABC) transporter
LK06_RS16230	COG0561	phosphatase activity
LK06_RS16235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LK06_RS16290	COG0006	proline dipeptidase activity
LK06_RS16330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK06_RS16485	COG3547	Transposase (IS116 IS110 IS902 family)
LK06_RS16490	COG1595	DNA-templated transcription, initiation
LK06_RS16495	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS16500	COG2814	Major facilitator Superfamily
LK06_RS16505	COG1309	transcriptional regulator
LK06_RS16510	COG0784	Response regulator, receiver
LK06_RS16590	COG3629	intracellular signal transduction
LK06_RS16590	COG3903	Transcriptional regulator
LK06_RS16615	COG0745	RESPONSE REGULATOR receiver
LK06_RS16620	COG2205	protein histidine kinase activity
LK06_RS16630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LK06_RS16635	COG0477	Major facilitator Superfamily
LK06_RS16670	COG1191	sigma factor activity
LK06_RS16675	COG1191	sigma factor activity
LK06_RS16710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LK06_RS16835	COG3415	Transposase
LK06_RS16835	COG2801	Transposase and inactivated derivatives
LK06_RS16955	COG0151	Belongs to the GarS family
LK06_RS16970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LK06_RS16980	COG2197	response regulator
LK06_RS17015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK06_RS17020	COG0047	phosphoribosylformylglycinamidine synthase activity
LK06_RS17025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK06_RS17045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LK06_RS17055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LK06_RS17080	COG1643	Atp-dependent helicase
LK06_RS17115	COG0513	Belongs to the DEAD box helicase family
LK06_RS17205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LK06_RS17255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK06_RS17265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK06_RS17265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK06_RS17285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LK06_RS17290	COG0579	oxidoreductase
LK06_RS17315	COG1252	NADH dehydrogenase
LK06_RS17435	COG0697	spore germination
LK06_RS17440	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS17445	COG1982	Orn Lys Arg decarboxylase major
LK06_RS17465	COG0583	DNA-binding transcription factor activity
LK06_RS17475	COG1309	transcriptional regulator
LK06_RS17480	COG0791	NLP P60 protein
LK06_RS17485	COG0671	phosphoesterase, PA-phosphatase related
LK06_RS17490	COG0277	FAD linked oxidase domain protein
LK06_RS17495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LK06_RS17510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK06_RS17520	COG0306	phosphate transporter
LK06_RS17530	COG1937	Protein conserved in bacteria
LK06_RS17540	COG0406	alpha-ribazole phosphatase activity
LK06_RS17540	COG0494	nUDIX hydrolase
LK06_RS17550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LK06_RS17555	COG0456	acetyltransferase
LK06_RS17565	COG0745	RESPONSE REGULATOR receiver
LK06_RS17575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK06_RS17580	COG1609	Transcriptional regulator
LK06_RS17585	COG0745	RESPONSE REGULATOR receiver
LK06_RS17620	COG2897	thiosulfate sulfurtransferase activity
LK06_RS17635	COG0156	8-amino-7-oxononanoate synthase activity
LK06_RS17665	COG3485	protocatechuate 3,4-dioxygenase
LK06_RS17670	COG0735	belongs to the Fur family
LK06_RS17675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK06_RS17680	COG1490	D-aminoacyl-tRNA deacylase activity
LK06_RS17690	COG4552	Acetyltransferase involved in intracellular survival and related
LK06_RS17695	COG2188	Transcriptional regulator
LK06_RS17705	COG0546	phosphoglycolate phosphatase activity
LK06_RS17715	COG1309	transcriptional regulator
LK06_RS17720	COG3973	AAA domain
LK06_RS17730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK06_RS17795	COG0438	transferase activity, transferring glycosyl groups
LK06_RS17805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK06_RS17815	COG0588	phosphoglycerate mutase activity
LK06_RS17840	COG5002	protein histidine kinase activity
LK06_RS17860	COG1329	Transcriptional regulator
LK06_RS17870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LK06_RS17875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LK06_RS17885	COG0215	cysteine-tRNA ligase activity
LK06_RS17890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK06_RS17910	COG3842	ATPase activity
LK06_RS17920	COG0582	viral genome integration into host DNA
LK06_RS17970	COG2188	Transcriptional regulator
LK06_RS18030	COG4974	Belongs to the 'phage' integrase family
LK06_RS18110	COG0592	DNA-directed DNA polymerase activity
LK06_RS18125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK06_RS18130	COG0726	polysaccharide deacetylase
LK06_RS18140	COG1131	(ABC) transporter
LK06_RS18150	COG4585	Histidine kinase
LK06_RS18155	COG2197	response regulator
LK06_RS18170	COG0456	acetyltransferase
LK06_RS18215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LK06_RS18230	COG3300	MHYT domain
LK06_RS18230	COG5001	Diguanylate cyclase
LK06_RS18280	COG0463	Glycosyl transferase, family 2
LK06_RS18295	COG1278	Cold shock
LK06_RS18300	COG0459	protein refolding
LK06_RS18345	COG1263	PTS System
LK06_RS18345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK06_RS18350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LK06_RS18355	COG1737	Transcriptional regulator
LK06_RS18380	COG3773	Cell wall hydrolase
LK06_RS18380	COG3409	Peptidoglycan-binding domain 1 protein
LK06_RS18395	COG3409	Peptidoglycan-binding domain 1 protein
LK06_RS18415	COG3973	AAA domain
LK06_RS18435	COG1061	Type III restriction enzyme res subunit
LK06_RS18460	COG1278	Cold shock
LK06_RS18465	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LK06_RS18470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LK06_RS18480	COG2814	Major facilitator Superfamily
LK06_RS18545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK06_RS18555	COG2252	PERMEase
LK06_RS18585	COG0667	Aldo Keto reductase
LK06_RS18605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LK06_RS18610	COG0277	FAD linked oxidase domain protein
LK06_RS18610	COG0247	lactate metabolic process
LK06_RS18620	COG1132	(ABC) transporter
LK06_RS18625	COG5006	permease, DMT superfamily
LK06_RS18655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK06_RS18670	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS18680	COG1309	transcriptional regulator
LK06_RS18695	COG0259	pyridoxamine-phosphate oxidase activity
LK06_RS18710	COG4821	SIS domain
LK06_RS18775	COG1366	Belongs to the anti-sigma-factor antagonist family
LK06_RS18780	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS18790	COG1960	acyl-CoA dehydrogenase activity
LK06_RS18795	COG1960	acyl-CoA dehydrogenase activity
LK06_RS18815	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS18820	COG1960	acyl-CoA dehydrogenase activity
LK06_RS18850	COG1024	Enoyl-CoA hydratase
LK06_RS18860	COG2072	flavoprotein involved in K transport
LK06_RS18890	COG1960	acyl-CoA dehydrogenase activity
LK06_RS18915	COG1280	lysine exporter protein (LysE YggA)
LK06_RS18920	COG1522	sequence-specific DNA binding
LK06_RS18925	COG1309	transcriptional regulator
LK06_RS18935	COG0515	serine threonine protein kinase
LK06_RS18935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK06_RS18940	COG1024	Enoyl-CoA hydratase
LK06_RS18960	COG3903	Transcriptional regulator
LK06_RS18960	COG3629	intracellular signal transduction
LK06_RS18985	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LK06_RS18990	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS19010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LK06_RS19030	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS19070	COG0386	Belongs to the glutathione peroxidase family
LK06_RS19090	COG2205	protein histidine kinase activity
LK06_RS19095	COG0745	RESPONSE REGULATOR receiver
LK06_RS19125	COG0515	serine threonine protein kinase
LK06_RS19125	COG2815	serine threonine protein kinase
LK06_RS19130	COG0412	Dienelactone hydrolase
LK06_RS19135	COG0515	serine threonine protein kinase
LK06_RS19135	COG2815	serine threonine protein kinase
LK06_RS19140	COG1136	(ABC) transporter
LK06_RS19140	COG0577	efflux transmembrane transporter activity
LK06_RS19145	COG1136	(ABC) transporter
LK06_RS19155	COG0745	RESPONSE REGULATOR receiver
LK06_RS19160	COG5002	protein histidine kinase activity
LK06_RS19230	COG1942	4-Oxalocrotonate Tautomerase
LK06_RS19240	COG2814	Major facilitator Superfamily
LK06_RS19245	COG0583	DNA-binding transcription factor activity
LK06_RS19275	COG3384	dioxygenase
LK06_RS19300	COG0477	Major facilitator Superfamily
LK06_RS19315	COG3191	aminopeptidase activity
LK06_RS19330	COG1970	mechanosensitive ion channel activity
LK06_RS19340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LK06_RS19365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LK06_RS19370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK06_RS19380	COG0315	cyclic pyranopterin monophosphate synthase activity
LK06_RS19385	COG0521	Mo-molybdopterin cofactor biosynthetic process
LK06_RS19385	COG0315	cyclic pyranopterin monophosphate synthase activity
LK06_RS19420	COG0582	viral genome integration into host DNA
LK06_RS19490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LK06_RS19575	COG0148	phosphopyruvate hydratase activity
LK06_RS19580	COG0454	-acetyltransferase
LK06_RS19595	COG2072	flavoprotein involved in K transport
LK06_RS19600	COG2267	carboxylic ester hydrolase activity
LK06_RS19605	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS19615	COG4946	Tricorn protease homolog
LK06_RS19615	COG0793	Belongs to the peptidase S41A family
LK06_RS19625	COG2409	Drug exporters of the RND superfamily
LK06_RS19645	COG1764	response to oxidative stress
LK06_RS19650	COG1846	Transcriptional regulator
LK06_RS19655	COG1122	ATPase activity
LK06_RS19665	COG0310	cobalt ion transport
LK06_RS19675	COG0768	penicillin binding
LK06_RS19700	COG0084	hydrolase, TatD family'
LK06_RS19710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK06_RS19715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LK06_RS19720	COG0488	(ABC) transporter
LK06_RS19755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LK06_RS19780	COG2197	response regulator
LK06_RS19790	COG4106	trans-aconitate 2-methyltransferase activity
LK06_RS19800	COG1309	transcriptional regulator
LK06_RS19810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LK06_RS19820	COG0193	aminoacyl-tRNA hydrolase activity
LK06_RS19825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LK06_RS19830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LK06_RS19835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LK06_RS19850	COG4585	Histidine kinase
LK06_RS19935	COG1652	LysM domain
LK06_RS19945	COG0148	phosphopyruvate hydratase activity
LK06_RS19980	COG1252	NADH dehydrogenase
LK06_RS19985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LK06_RS19990	COG0577	efflux transmembrane transporter activity
LK06_RS19995	COG0577	efflux transmembrane transporter activity
LK06_RS19995	COG1136	(ABC) transporter
LK06_RS20025	COG0183	Belongs to the thiolase family
LK06_RS20030	COG2755	lipolytic protein G-D-S-L family
LK06_RS20040	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS20045	COG0736	holo-[acyl-carrier-protein] synthase activity
LK06_RS20055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK06_RS20065	COG0802	atpase or kinase
LK06_RS20085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LK06_RS20105	COG0726	polysaccharide deacetylase
LK06_RS20110	COG0726	polysaccharide deacetylase
LK06_RS20120	COG0459	protein refolding
LK06_RS20130	COG4221	oxidoreductase activity
LK06_RS20140	COG0583	DNA-binding transcription factor activity
LK06_RS20150	COG2197	response regulator
LK06_RS20155	COG1595	DNA-templated transcription, initiation
LK06_RS20165	COG0516	GMP reductase activity
LK06_RS20180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LK06_RS20190	COG0515	serine threonine protein kinase
LK06_RS20190	COG2815	serine threonine protein kinase
LK06_RS20195	COG0515	serine threonine protein kinase
LK06_RS20200	COG0515	serine threonine protein kinase
LK06_RS20200	COG2815	serine threonine protein kinase
LK06_RS20205	COG0515	serine threonine protein kinase
LK06_RS20210	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS20225	COG0519	Catalyzes the synthesis of GMP from XMP
LK06_RS20225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LK06_RS20265	COG2197	response regulator
LK06_RS20290	COG0739	heme binding
LK06_RS20300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS20300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS20315	COG0714	Associated with various cellular activities
LK06_RS20325	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LK06_RS20330	COG0045	succinate-CoA ligase (ADP-forming) activity
LK06_RS20360	COG0138	bifunctional purine biosynthesis protein purh
LK06_RS20380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LK06_RS20395	COG0039	L-malate dehydrogenase activity
LK06_RS20400	COG0477	Major facilitator Superfamily
LK06_RS20410	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS20420	COG0517	IMP dehydrogenase activity
LK06_RS20420	COG4175	Glycine betaine
LK06_RS20425	COG4176	ABC-type proline glycine betaine transport system permease component
LK06_RS20440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK06_RS20450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK06_RS20480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK06_RS20485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK06_RS20490	COG0180	Tryptophanyl-tRNA synthetase
LK06_RS20505	COG1295	ribonuclease BN
LK06_RS20510	COG1686	Belongs to the peptidase S11 family
LK06_RS20525	COG1309	transcriptional regulator
LK06_RS20540	COG1053	succinate dehydrogenase
LK06_RS20550	COG2009	succinate dehydrogenase
LK06_RS20560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LK06_RS20595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS20595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS20610	COG1216	Glycosyl transferase, family 2
LK06_RS20625	COG2089	acid synthase
LK06_RS20645	COG2205	protein histidine kinase activity
LK06_RS20650	COG0745	RESPONSE REGULATOR receiver
LK06_RS20665	COG1376	ErfK ybiS ycfS ynhG family protein
LK06_RS20675	COG1473	amidohydrolase
LK06_RS20675	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LK06_RS20680	COG1744	ABC transporter substrate-binding protein PnrA-like
LK06_RS20685	COG3845	ABC transporter
LK06_RS20690	COG4603	Belongs to the binding-protein-dependent transport system permease family
LK06_RS20695	COG1079	Belongs to the binding-protein-dependent transport system permease family
LK06_RS20725	COG2814	Major facilitator Superfamily
LK06_RS20730	COG0583	DNA-binding transcription factor activity
LK06_RS20740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK06_RS20765	COG2205	protein histidine kinase activity
LK06_RS20770	COG0745	RESPONSE REGULATOR receiver
LK06_RS20775	COG1595	DNA-templated transcription, initiation
LK06_RS20790	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS20795	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS20800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LK06_RS20810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK06_RS20835	COG4770	biotin carboxylase activity
LK06_RS20845	COG0424	maF-like protein
LK06_RS20860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK06_RS20870	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LK06_RS20880	COG1024	Enoyl-CoA hydratase
LK06_RS20890	COG2986	histidine ammonia-lyase
LK06_RS20920	COG1136	(ABC) transporter
LK06_RS20935	COG1064	alcohol dehydrogenase
LK06_RS20945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK06_RS20950	COG0477	Major facilitator Superfamily
LK06_RS20975	COG2255	four-way junction helicase activity
LK06_RS20980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LK06_RS20995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LK06_RS21005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LK06_RS21015	COG1331	Highly conserved protein containing a thioredoxin domain
LK06_RS21030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK06_RS21050	COG0300	oxidoreductase activity
LK06_RS21050	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS21050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS21050	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS21050	COG3321	synthase
LK06_RS21050	COG0300	oxidoreductase activity
LK06_RS21050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS21050	COG3321	synthase
LK06_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS21055	COG3251	PFAM MbtH domain protein
LK06_RS21090	COG2175	clavaminate synthase activity
LK06_RS21095	COG2197	response regulator
LK06_RS21100	COG1136	(ABC) transporter
LK06_RS21100	COG0577	efflux transmembrane transporter activity
LK06_RS21110	COG4585	Histidine kinase
LK06_RS21140	COG0154	amidase activity
LK06_RS21155	COG1331	Highly conserved protein containing a thioredoxin domain
LK06_RS21170	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LK06_RS21180	COG0436	Aminotransferase
LK06_RS21200	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LK06_RS21220	COG0251	oxidation-reduction process
LK06_RS21260	COG2894	cell division
LK06_RS21295	COG2197	response regulator
LK06_RS21320	COG1309	transcriptional regulator
LK06_RS21330	COG1073	alpha beta
LK06_RS21330	COG2226	methyltransferase
LK06_RS21335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK06_RS21345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LK06_RS21350	COG0741	lytic transglycosylase activity
LK06_RS21365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK06_RS21370	COG0450	alkyl hydroperoxide reductase
LK06_RS21400	COG1136	(ABC) transporter
LK06_RS21420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK06_RS21435	COG0114	fumarate hydratase activity
LK06_RS21470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LK06_RS21470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LK06_RS21495	COG0778	Nitroreductase
LK06_RS21500	COG1722	exodeoxyribonuclease VII activity
LK06_RS21505	COG1570	exodeoxyribonuclease VII activity
LK06_RS21510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LK06_RS21525	COG0012	GTP binding
LK06_RS21795	COG1053	succinate dehydrogenase
LK06_RS21815	COG1217	gtp-binding protein TYPA
LK06_RS21820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK06_RS21825	COG4166	transmembrane transport
LK06_RS21830	COG0601	transmembrane transport
LK06_RS21835	COG0444	Belongs to the ABC transporter superfamily
LK06_RS21845	COG4608	Belongs to the ABC transporter superfamily
LK06_RS21860	COG4608	Belongs to the ABC transporter superfamily
LK06_RS21865	COG0444	Belongs to the ABC transporter superfamily
LK06_RS21870	COG0601	transmembrane transport
LK06_RS21880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK06_RS21890	COG0601	transmembrane transport
LK06_RS21895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK06_RS21900	COG0444	Belongs to the ABC transporter superfamily
LK06_RS21905	COG4608	Belongs to the ABC transporter superfamily
LK06_RS21920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LK06_RS21935	COG1131	(ABC) transporter
LK06_RS21945	COG4585	Histidine kinase
LK06_RS21950	COG2197	response regulator
LK06_RS21985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK06_RS21990	COG1611	Belongs to the LOG family
LK06_RS21995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LK06_RS22005	COG0519	Catalyzes the synthesis of GMP from XMP
LK06_RS22010	COG1024	Enoyl-CoA hydratase
LK06_RS22025	COG1595	DNA-templated transcription, initiation
LK06_RS22040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK06_RS22075	COG0598	Magnesium transport protein CorA
LK06_RS22090	COG0613	PHP domain protein
LK06_RS22095	COG2095	MarC family integral membrane protein
LK06_RS22105	COG1432	Conserved Protein
LK06_RS22205	COG0210	DNA helicase
LK06_RS22210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK06_RS22215	COG2816	NAD+ diphosphatase activity
LK06_RS22250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LK06_RS22300	COG3480	Lon protease (S16) C-terminal proteolytic domain
LK06_RS22310	COG1615	UPF0182 protein
LK06_RS22340	COG0483	inositol monophosphate 1-phosphatase activity
LK06_RS22350	COG2076	Multidrug Resistance protein
LK06_RS22360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LK06_RS22370	COG2135	peptidase activity
LK06_RS22380	COG1595	DNA-templated transcription, initiation
LK06_RS22385	COG5662	AntiSigma factor
LK06_RS22390	COG2199	diguanylate cyclase activity
LK06_RS22390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LK06_RS22405	COG0242	peptide deformylase activity
LK06_RS22415	COG2124	cytochrome p450
LK06_RS22420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK06_RS22445	COG2188	Transcriptional regulator
LK06_RS22450	COG0363	glucosamine-6-phosphate deaminase activity
LK06_RS22465	COG1597	lipid kinase activity
LK06_RS22480	COG2172	sigma factor antagonist activity
LK06_RS22495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LK06_RS22500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LK06_RS22505	COG0142	geranyltranstransferase activity
LK06_RS22560	COG1126	abc transporter atp-binding protein
LK06_RS22565	COG0765	amino acid transport
LK06_RS22580	COG0281	malic enzyme
LK06_RS22585	COG0604	alcohol dehydrogenase
LK06_RS22630	COG2255	four-way junction helicase activity
LK06_RS22655	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK06_RS22655	COG0567	Dehydrogenase, E1 component
LK06_RS22660	COG2205	protein histidine kinase activity
LK06_RS22665	COG0745	RESPONSE REGULATOR receiver
LK06_RS22680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK06_RS22770	COG2205	protein histidine kinase activity
LK06_RS22790	COG3285	dna ligase
LK06_RS22790	COG1793	dna ligase
LK06_RS22795	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LK06_RS22805	COG0640	Transcriptional regulator
LK06_RS22810	COG0671	phosphoesterase, PA-phosphatase related
LK06_RS22815	COG0586	Pfam SNARE associated Golgi protein
LK06_RS22850	COG2217	Heavy metal translocating P-type atpase
LK06_RS22880	COG0516	GMP reductase activity
LK06_RS22880	COG0517	IMP dehydrogenase activity
LK06_RS23060	COG3883	PFAM NLP P60 protein
LK06_RS23060	COG0791	NLP P60 protein
LK06_RS23090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK06_RS23150	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LK06_RS23170	COG3547	Transposase (IS116 IS110 IS902 family)
LK06_RS23195	COG0745	RESPONSE REGULATOR receiver
LK06_RS23200	COG0018	arginyl-trna synthetase
LK06_RS23200	COG0018	arginyl-trna synthetase
LK06_RS23205	COG0019	diaminopimelate decarboxylase activity
LK06_RS23210	COG0460	homoserine dehydrogenase
LK06_RS23215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LK06_RS23220	COG0083	homoserine kinase activity
LK06_RS23230	COG1316	TRANSCRIPTIONal
LK06_RS23235	COG0254	rRNA binding
LK06_RS23240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LK06_RS23245	COG2890	protein-(glutamine-N5) methyltransferase activity
LK06_RS23255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK06_RS23260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK06_RS23265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK06_RS23280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK06_RS23285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LK06_RS23290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK06_RS23295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LK06_RS23300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LK06_RS23305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LK06_RS23310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LK06_RS23365	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK06_RS23380	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LK06_RS23415	COG1131	(ABC) transporter
LK06_RS23435	COG0183	Belongs to the thiolase family
LK06_RS23505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS23505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS23545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LK06_RS23550	COG0280	phosphate acetyltransferase
LK06_RS23550	COG0857	belongs to the CobB CobQ family
LK06_RS23555	COG0205	6-phosphofructokinase activity
LK06_RS23570	COG4565	transcriptional regulatory protein
LK06_RS23575	COG3290	protein histidine kinase activity
LK06_RS23580	COG1301	dicarboxylic acid transport
LK06_RS23590	COG0477	Major facilitator Superfamily
LK06_RS23610	COG3118	belongs to the thioredoxin family
LK06_RS23620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK06_RS23625	COG3281	Trehalose synthase
LK06_RS23635	COG0366	Alpha amylase catalytic
LK06_RS23640	COG0058	SHG alpha-glucan phosphorylase activity
LK06_RS23655	COG1132	(ABC) transporter
LK06_RS23660	COG1132	(ABC) transporter
LK06_RS23690	COG1376	ErfK ybiS ycfS ynhG family protein
LK06_RS23695	COG1376	ErfK ybiS ycfS ynhG family protein
LK06_RS23730	COG1388	LysM domain
LK06_RS23730	COG3942	CHAP domain
LK06_RS23735	COG1760	l-serine dehydratase
LK06_RS23740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK06_RS23745	COG0509	glycine decarboxylation via glycine cleavage system
LK06_RS23750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK06_RS23770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK06_RS23785	COG0444	Belongs to the ABC transporter superfamily
LK06_RS23790	COG4608	Belongs to the ABC transporter superfamily
LK06_RS23795	COG2860	membrane
LK06_RS23815	COG2378	regulation of single-species biofilm formation
LK06_RS23845	COG0482	sulfurtransferase activity
LK06_RS23860	COG1611	Belongs to the LOG family
LK06_RS23865	COG4221	oxidoreductase activity
LK06_RS23875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK06_RS23885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK06_RS23890	COG0154	amidase activity
LK06_RS23900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK06_RS23910	COG2409	Drug exporters of the RND superfamily
LK06_RS23915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK06_RS23925	COG2197	response regulator
LK06_RS23935	COG2133	pyrroloquinoline quinone binding
LK06_RS23940	COG0667	Aldo Keto reductase
LK06_RS23950	COG5001	Diguanylate cyclase
LK06_RS23960	COG0440	acetolactate synthase activity
LK06_RS23965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LK06_RS23975	COG0477	Major facilitator Superfamily
LK06_RS24005	COG0506	proline dehydrogenase activity
LK06_RS24010	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS24020	COG0473	3-isopropylmalate dehydrogenase activity
LK06_RS24025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK06_RS24035	COG0832	Belongs to the urease beta subunit family
LK06_RS24035	COG0831	urea catabolic process
LK06_RS24040	COG0804	urea catabolic process
LK06_RS24045	COG2957	Belongs to the agmatine deiminase family
LK06_RS24060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK06_RS24070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK06_RS24090	COG2018	Roadblock/LC7 domain
LK06_RS24110	COG2018	Roadblock/LC7 domain
LK06_RS24115	COG5002	protein histidine kinase activity
LK06_RS24125	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK06_RS24130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK06_RS24175	COG1414	Transcriptional regulator
LK06_RS24180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LK06_RS24185	COG0066	3-isopropylmalate dehydratase activity
LK06_RS24195	COG0776	regulation of translation
LK06_RS24205	COG1920	GTP binding
LK06_RS24215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK06_RS24220	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK06_RS24240	COG0351	phosphomethylpyrimidine kinase
LK06_RS24245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK06_RS24250	COG1461	Dihydroxyacetone kinase
LK06_RS24260	COG0326	Molecular chaperone. Has ATPase activity
LK06_RS24270	COG0742	ribosomal rna small subunit methyltransferase
LK06_RS24275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LK06_RS24290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LK06_RS24295	COG0571	ribonuclease III activity
LK06_RS24300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK06_RS24305	COG1733	regulation of RNA biosynthetic process
LK06_RS24320	COG2340	Cysteine-rich secretory protein family
LK06_RS24325	COG1254	Belongs to the acylphosphatase family
LK06_RS24350	COG0477	Major facilitator Superfamily
LK06_RS24385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LK06_RS24395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK06_RS24400	COG4106	trans-aconitate 2-methyltransferase activity
LK06_RS24410	COG0228	four-way junction DNA binding
LK06_RS24415	COG1837	Belongs to the UPF0109 family
LK06_RS24420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LK06_RS24425	COG0336	Belongs to the RNA methyltransferase TrmD family
LK06_RS24430	COG0335	large ribosomal subunit rRNA binding
LK06_RS24440	COG0681	Belongs to the peptidase S26 family
LK06_RS24465	COG0792	nuclease activity
LK06_RS24480	COG1191	sigma factor activity
LK06_RS24495	COG0052	Belongs to the universal ribosomal protein uS2 family
LK06_RS24500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LK06_RS24505	COG0528	UMP kinase activity
LK06_RS24510	COG0233	cytoplasmic translational termination
LK06_RS24515	COG0575	Belongs to the CDS family
LK06_RS24525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LK06_RS24535	COG4208	sulfate ABC transporter
LK06_RS24540	COG3842	ATPase activity
LK06_RS24565	COG1136	(ABC) transporter
LK06_RS24570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK06_RS24580	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS24600	COG0584	glycerophosphoryl diester phosphodiesterase
LK06_RS24605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK06_RS24630	COG3842	ATPase activity
LK06_RS24635	COG1176	ABC-type spermidine putrescine transport system, permease component I
LK06_RS24640	COG1177	transmembrane transport
LK06_RS24645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK06_RS24675	COG2508	Transcriptional regulator
LK06_RS24680	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS24700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LK06_RS24705	COG0750	zinc metalloprotease
LK06_RS24710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK06_RS24725	COG0442	prolyl-tRNA aminoacylation
LK06_RS24750	COG0779	Required for maturation of 30S ribosomal subunits
LK06_RS24765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LK06_RS24775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LK06_RS24780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LK06_RS24795	COG0455	bacterial-type flagellum organization
LK06_RS24815	COG1404	Belongs to the peptidase S8 family
LK06_RS24840	COG1404	Belongs to the peptidase S8 family
LK06_RS24855	COG1674	ftsk spoiiie
LK06_RS24875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LK06_RS24880	COG1185	polyribonucleotide nucleotidyltransferase activity
LK06_RS24885	COG0612	Peptidase, M16
LK06_RS24890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LK06_RS24910	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LK06_RS24915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK06_RS24920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LK06_RS24955	COG2770	Histidine kinase
LK06_RS24955	COG2208	phosphoserine phosphatase activity
LK06_RS24965	COG0784	Response regulator, receiver
LK06_RS24965	COG2205	protein histidine kinase activity
LK06_RS24975	COG1674	ftsk spoiiie
LK06_RS24985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK06_RS24995	COG1058	Belongs to the CinA family
LK06_RS24995	COG1546	Belongs to the CinA family
LK06_RS25000	COG1396	sequence-specific DNA binding
LK06_RS25005	COG0783	Belongs to the Dps family
LK06_RS25020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK06_RS25025	COG1201	RNA secondary structure unwinding
LK06_RS25040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LK06_RS25060	COG0765	amino acid transport
LK06_RS25065	COG0765	amino acid transport
LK06_RS25070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK06_RS25075	COG1126	abc transporter atp-binding protein
LK06_RS25080	COG0745	RESPONSE REGULATOR receiver
LK06_RS25085	COG2205	protein histidine kinase activity
LK06_RS25115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK06_RS25125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK06_RS25135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LK06_RS25140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK06_RS25150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LK06_RS25195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LK06_RS25200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LK06_RS25205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK06_RS25220	COG0588	phosphoglycerate mutase activity
LK06_RS25230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK06_RS25270	COG1131	(ABC) transporter
LK06_RS25275	COG2186	Transcriptional regulator
LK06_RS25280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK06_RS25295	COG0187	DNA topoisomerase II activity
LK06_RS25310	COG4585	Histidine kinase
LK06_RS25315	COG2197	response regulator
LK06_RS25325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK06_RS25335	COG4565	transcriptional regulatory protein
LK06_RS25340	COG3290	protein histidine kinase activity
LK06_RS25355	COG0372	Belongs to the citrate synthase family
LK06_RS25360	COG0523	cobalamin synthesis protein
LK06_RS25365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK06_RS25370	COG0612	Peptidase, M16
LK06_RS25385	COG1802	Transcriptional regulator
LK06_RS25390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK06_RS25400	COG0045	succinate-CoA ligase (ADP-forming) activity
LK06_RS25400	COG1042	CoA-binding domain protein
LK06_RS25400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK06_RS25415	COG1435	thymidine kinase activity
LK06_RS25440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LK06_RS25450	COG0745	RESPONSE REGULATOR receiver
LK06_RS25455	COG2205	protein histidine kinase activity
LK06_RS25480	COG0756	dUTP diphosphatase activity
LK06_RS25515	COG0569	domain protein
LK06_RS25520	COG0531	amino acid
LK06_RS25525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK06_RS25575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK06_RS25590	COG4974	Belongs to the 'phage' integrase family
LK06_RS25605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK06_RS25660	COG0156	8-amino-7-oxononanoate synthase activity
LK06_RS25665	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS25675	COG0604	alcohol dehydrogenase
LK06_RS25675	COG3321	synthase
LK06_RS25680	COG0477	Major facilitator Superfamily
LK06_RS25690	COG2197	response regulator
LK06_RS25775	COG2920	part of a sulfur-relay system
LK06_RS25780	COG1252	NADH dehydrogenase
LK06_RS25785	COG0500	methyltransferase
LK06_RS25800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK06_RS25830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK06_RS25845	COG1215	transferase activity, transferring glycosyl groups
LK06_RS25855	COG4310	Domain of unknown function (DUF2172)
LK06_RS25870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK06_RS25880	COG0438	transferase activity, transferring glycosyl groups
LK06_RS25905	COG0367	asparagine synthase
LK06_RS25925	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LK06_RS25975	COG1595	DNA-templated transcription, initiation
LK06_RS25980	COG0531	amino acid
LK06_RS26000	COG1799	cell septum assembly
LK06_RS26050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LK06_RS26060	COG2235	arginine
LK06_RS26065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK06_RS26070	COG0531	amino acid
LK06_RS26080	COG1024	Enoyl-CoA hydratase
LK06_RS26115	COG2188	Transcriptional regulator
LK06_RS26120	COG2182	Extracellular solute-binding protein
LK06_RS26125	COG1175	transmembrane transport
LK06_RS26130	COG0395	ABC-type sugar transport system, permease component
LK06_RS26135	COG1472	Belongs to the glycosyl hydrolase 3 family
LK06_RS26205	COG2197	response regulator
LK06_RS26220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK06_RS26225	COG1960	acyl-CoA dehydrogenase activity
LK06_RS26235	COG0367	asparagine synthase
LK06_RS26250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK06_RS26255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK06_RS26280	COG0477	Major facilitator Superfamily
LK06_RS26290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK06_RS26300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK06_RS26310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK06_RS26335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK06_RS26350	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS26365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK06_RS26390	COG2130	NADP-dependent
LK06_RS26400	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK06_RS26410	COG2368	4-hydroxyphenylacetate
LK06_RS26415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LK06_RS26510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK06_RS26520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK06_RS26530	COG1653	transport
LK06_RS26535	COG1175	transmembrane transport
LK06_RS26540	COG0395	ABC-type sugar transport system, permease component
LK06_RS26545	COG1940	carbohydrate kinase activity
LK06_RS26550	COG4213	ABC transporter substrate-binding protein
LK06_RS26560	COG4214	carbohydrate transport
LK06_RS26565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK06_RS26570	COG0531	amino acid
LK06_RS26595	COG1024	Enoyl-CoA hydratase
LK06_RS26595	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK06_RS26600	COG0183	Belongs to the thiolase family
LK06_RS26605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LK06_RS26620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LK06_RS26635	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK06_RS26650	COG3253	May function as heme-dependent peroxidase
LK06_RS26665	COG3220	belongs to the UPF0276 family
LK06_RS26675	COG2801	Transposase and inactivated derivatives
LK06_RS26690	COG0330	HflC and HflK could
LK06_RS26735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK06_RS26740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK06_RS26755	COG1174	glycine betaine transport
LK06_RS26760	COG1174	glycine betaine transport
LK06_RS26775	COG2018	Roadblock/LC7 domain
LK06_RS26780	COG5002	protein histidine kinase activity
LK06_RS26830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK06_RS26840	COG3173	Aminoglycoside phosphotransferase
LK06_RS26905	COG2409	Drug exporters of the RND superfamily
LK06_RS26915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK06_RS26955	COG0529	Catalyzes the synthesis of activated sulfate
LK06_RS26960	COG0175	sulfate reduction
LK06_RS26990	COG1960	acyl-CoA dehydrogenase activity
LK06_RS27010	COG3739	integral membrane protein
LK06_RS27015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LK06_RS27035	COG2040	homocysteine
LK06_RS27045	COG1309	transcriptional regulator
LK06_RS27070	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LK06_RS27075	COG1162	GTPase activity
LK06_RS27105	COG1802	Transcriptional regulator
LK06_RS27120	COG3835	regulator
LK06_RS27140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LK06_RS27145	COG2252	PERMEase
LK06_RS27160	COG0726	polysaccharide deacetylase
LK06_RS27180	COG1605	Chorismate mutase
LK06_RS27185	COG0512	Glutamine amidotransferase of anthranilate synthase
LK06_RS27185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LK06_RS27190	COG0287	Prephenate dehydrogenase
LK06_RS27195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK06_RS27200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK06_RS27220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK06_RS27230	COG1045	serine acetyltransferase
LK06_RS27240	COG0151	Belongs to the GarS family
LK06_RS27260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK06_RS27285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LK06_RS27315	COG0598	Magnesium transport protein CorA
LK06_RS27335	COG2197	response regulator
LK06_RS27340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK06_RS27345	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS27355	COG3960	tartronate-semialdehyde synthase activity
LK06_RS27370	COG0753	catalase activity
LK06_RS27375	COG2084	Dehydrogenase
LK06_RS27380	COG3622	Belongs to the hyi family
LK06_RS27400	COG2351	hydroxyisourate hydrolase activity
LK06_RS27420	COG2233	PERMEase
LK06_RS27435	COG0406	alpha-ribazole phosphatase activity
LK06_RS27440	COG0436	Aminotransferase
LK06_RS27445	COG1733	regulation of RNA biosynthetic process
LK06_RS27460	COG4264	IucA IucC family
LK06_RS27465	COG4264	IucA IucC family
LK06_RS27505	COG2801	Transposase and inactivated derivatives
LK06_RS27520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LK06_RS27525	COG0746	molybdenum cofactor guanylyltransferase activity
LK06_RS27535	COG1414	Transcriptional regulator
LK06_RS27540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK06_RS27545	COG4266	Belongs to the allantoicase family
LK06_RS27565	COG0673	inositol 2-dehydrogenase activity
LK06_RS27570	COG2188	Transcriptional regulator
LK06_RS27590	COG1940	carbohydrate kinase activity
LK06_RS27600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK06_RS27620	COG1032	radical SAM domain protein
LK06_RS27625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LK06_RS27645	COG2814	Major facilitator Superfamily
LK06_RS27660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK06_RS27665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK06_RS27670	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LK06_RS27675	COG1063	alcohol dehydrogenase
LK06_RS27700	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS27705	COG4221	oxidoreductase activity
LK06_RS27720	COG0612	Peptidase, M16
LK06_RS27725	COG1132	(ABC) transporter
LK06_RS27785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK06_RS27790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK06_RS27815	COG0405	Gamma-glutamyltransferase
LK06_RS27820	COG0542	response to heat
LK06_RS27845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK06_RS27860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK06_RS27870	COG1953	Uracil, thiamine, allantoin
LK06_RS27880	COG0483	inositol monophosphate 1-phosphatase activity
LK06_RS27905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LK06_RS27910	COG0569	domain protein
LK06_RS27910	COG0475	glutathione-regulated potassium exporter activity
LK06_RS27925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LK06_RS27935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK06_RS27945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LK06_RS27955	COG1929	Belongs to the glycerate kinase type-1 family
LK06_RS27965	COG0688	phosphatidylethanolamine metabolic process
LK06_RS27970	COG1960	acyl-CoA dehydrogenase activity
LK06_RS27980	COG2301	Belongs to the HpcH HpaI aldolase family
LK06_RS27985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS27985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK06_RS28000	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK06_RS28010	COG0596	Alpha beta hydrolase
LK06_RS28040	COG2362	D-Aminopeptidase
LK06_RS28045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK06_RS28055	COG1619	proteins homologs of microcin C7 resistance protein MccF
LK06_RS28080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK06_RS28095	COG2226	methyltransferase
LK06_RS28100	COG0588	phosphoglycerate mutase activity
LK06_RS28105	COG0488	(ABC) transporter
LK06_RS28140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK06_RS28160	COG0443	Heat shock 70 kDa protein
LK06_RS28180	COG2154	pterin-4-alpha-carbinolamine dehydratase
LK06_RS28185	COG2226	methyltransferase
LK06_RS28200	COG4221	oxidoreductase activity
LK06_RS28210	COG0656	L-ascorbic acid biosynthetic process
LK06_RS28220	COG0583	DNA-binding transcription factor activity
LK06_RS28235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LK06_RS28240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK06_RS28285	COG1388	LysM domain
LK06_RS28285	COG3942	CHAP domain
LK06_RS28310	COG0438	transferase activity, transferring glycosyl groups
LK06_RS28330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK06_RS28335	COG0477	Major facilitator Superfamily
LK06_RS28350	COG0438	transferase activity, transferring glycosyl groups
LK06_RS28380	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LK06_RS28385	COG0166	Belongs to the GPI family
LK06_RS28400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK06_RS28435	COG1486	melibiose metabolic process
LK06_RS28440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LK06_RS28470	COG3883	PFAM NLP P60 protein
LK06_RS28470	COG0791	NLP P60 protein
LK06_RS28485	COG3903	Transcriptional regulator
LK06_RS28485	COG3629	intracellular signal transduction
LK06_RS28500	COG3511	phospholipase C
LK06_RS28535	COG1470	cell adhesion involved in biofilm formation
LK06_RS28540	COG1793	dna ligase
LK06_RS28575	COG1834	amidinotransferase
LK06_RS28580	COG0488	(ABC) transporter
LK06_RS28595	COG1515	deoxyribonuclease V activity
LK06_RS28605	COG3268	Saccharopine dehydrogenase
LK06_RS28615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK06_RS28620	COG0183	Belongs to the thiolase family
LK06_RS28625	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK06_RS28625	COG1024	Enoyl-CoA hydratase
LK06_RS28635	COG1113	amino acid transport
LK06_RS28645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK06_RS28655	COG0488	(ABC) transporter
LK06_RS28660	COG2183	response to ionizing radiation
LK06_RS28665	COG1024	Enoyl-CoA hydratase
LK06_RS28675	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LK06_RS28715	COG1134	teichoic acid transport
LK06_RS28720	COG1562	ergosterol biosynthetic process
LK06_RS28730	COG1233	COG1233 Phytoene dehydrogenase and related
LK06_RS28740	COG1657	PFAM Prenyltransferase squalene oxidase
LK06_RS28755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK06_RS28795	COG2755	lipolytic protein G-D-S-L family
LK06_RS28840	COG1063	alcohol dehydrogenase
LK06_RS28845	COG0156	8-amino-7-oxononanoate synthase activity
LK06_RS28850	COG0583	DNA-binding transcription factor activity
LK06_RS28860	COG3958	Transketolase
LK06_RS28865	COG3959	Transketolase, thiamine diphosphate binding domain
LK06_RS28910	COG0174	glutamine synthetase
LK06_RS28925	COG2267	carboxylic ester hydrolase activity
LK06_RS28930	COG0183	Belongs to the thiolase family
LK06_RS28990	COG0395	ABC-type sugar transport system, permease component
LK06_RS29000	COG1653	transport
LK06_RS29010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK06_RS29015	COG1131	(ABC) transporter
LK06_RS29050	COG0673	inositol 2-dehydrogenase activity
LK06_RS29070	COG0673	inositol 2-dehydrogenase activity
LK06_RS29075	COG1609	Transcriptional regulator
LK06_RS29090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK06_RS29105	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS29120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK06_RS29135	COG2197	response regulator
LK06_RS29180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK06_RS29220	COG0431	NADPH-dependent FMN reductase
LK06_RS29230	COG2223	nitrite transmembrane transporter activity
LK06_RS29235	COG2207	Transcriptional regulator
LK06_RS29245	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS29250	COG1846	Transcriptional regulator
LK06_RS29295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LK06_RS29310	COG1454	alcohol dehydrogenase
LK06_RS29310	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS29320	COG0531	amino acid
LK06_RS29330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK06_RS29335	COG0549	Belongs to the carbamate kinase family
LK06_RS29350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK06_RS29360	COG0076	glutamate decarboxylase activity
LK06_RS29380	COG1309	transcriptional regulator
LK06_RS29385	COG2409	Drug exporters of the RND superfamily
LK06_RS29400	COG2340	Cysteine-rich secretory protein family
LK06_RS29415	COG0604	alcohol dehydrogenase
LK06_RS29415	COG3321	synthase
LK06_RS29420	COG0604	alcohol dehydrogenase
LK06_RS29420	COG3321	synthase
LK06_RS29435	COG2124	cytochrome p450
LK06_RS29450	COG0142	geranyltranstransferase activity
LK06_RS29455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK06_RS29460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK06_RS29470	COG1090	epimerase
LK06_RS29485	COG2837	iron assimilation
LK06_RS29550	COG2755	lipolytic protein G-D-S-L family
LK06_RS29585	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS29590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LK06_RS29595	COG1012	belongs to the aldehyde dehydrogenase family
LK06_RS29610	COG1846	Transcriptional regulator
LK06_RS29610	COG1940	carbohydrate kinase activity
LK06_RS29655	COG2018	Roadblock/LC7 domain
LK06_RS29665	COG1946	Acyl-CoA thioesterase
LK06_RS29680	COG0254	rRNA binding
LK06_RS29700	COG1132	(ABC) transporter
LK06_RS29710	COG2072	flavoprotein involved in K transport
LK06_RS29715	COG0432	Pfam Uncharacterised protein family UPF0047
LK06_RS29725	COG4232	protein-disulfide reductase activity
LK06_RS29750	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS29755	COG0300	oxidoreductase activity
LK06_RS29780	COG4566	intracellular signal transduction
LK06_RS29800	COG0477	Major facilitator Superfamily
LK06_RS29815	COG2706	6-phosphogluconolactonase activity
LK06_RS29825	COG2971	BadF BadG BcrA BcrD
LK06_RS29830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK06_RS29835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK06_RS29850	COG1960	acyl-CoA dehydrogenase activity
LK06_RS29900	COG1846	Transcriptional regulator
LK06_RS29915	COG0584	glycerophosphoryl diester phosphodiesterase
LK06_RS29935	COG0204	Acyl-transferase
LK06_RS29955	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LK06_RS29980	COG1660	Displays ATPase and GTPase activities
LK06_RS29995	COG0445	tRNA wobble uridine modification
LK06_RS30015	COG1349	DNA-binding transcription factor activity
LK06_RS30020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK06_RS30030	COG2813	Specifically methylates the guanine in position
LK06_RS30040	COG1940	carbohydrate kinase activity
LK06_RS30085	COG1349	DNA-binding transcription factor activity
LK06_RS30125	COG0463	Glycosyl transferase, family 2
LK06_RS30130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LK06_RS30155	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS30195	COG2326	polyphosphate kinase activity
LK06_RS30220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK06_RS30220	COG1042	CoA-binding domain protein
LK06_RS30220	COG0045	succinate-CoA ligase (ADP-forming) activity
LK06_RS30280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK06_RS30320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK06_RS30325	COG1993	acr, cog1993
LK06_RS30330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK06_RS30335	COG1968	undecaprenyl-diphosphatase activity
LK06_RS30340	COG2186	Transcriptional regulator
LK06_RS30355	COG2066	Belongs to the glutaminase family
LK06_RS30365	COG5650	phosphatidylinositol metabolic process
LK06_RS30370	COG1686	Belongs to the peptidase S11 family
LK06_RS30375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LK06_RS30385	COG2226	methyltransferase
LK06_RS30390	COG2188	Transcriptional regulator
LK06_RS30395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK06_RS30400	COG3458	cephalosporin-C deacetylase activity
LK06_RS30415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LK06_RS30455	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK06_RS30455	COG1902	pentaerythritol trinitrate reductase activity
LK06_RS30480	COG1461	Dihydroxyacetone kinase
LK06_RS30485	COG2376	Dihydroxyacetone kinase
LK06_RS30500	COG1960	acyl-CoA dehydrogenase activity
LK06_RS30510	COG0477	Major facilitator Superfamily
LK06_RS30525	COG1309	transcriptional regulator
LK06_RS30550	COG2070	2-Nitropropane dioxygenase
LK06_RS30560	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS30590	COG1024	Enoyl-CoA hydratase
LK06_RS30635	COG0510	thiamine kinase activity
LK06_RS30660	COG2267	carboxylic ester hydrolase activity
LK06_RS30665	COG0367	asparagine synthase
LK06_RS30705	COG2409	Drug exporters of the RND superfamily
LK06_RS30735	COG0346	lactoylglutathione lyase activity
LK06_RS30740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK06_RS30750	COG0583	DNA-binding transcription factor activity
LK06_RS30770	COG0842	Transport permease protein
LK06_RS30770	COG1131	(ABC) transporter
LK06_RS30770	COG1716	ATPase activity
LK06_RS30780	COG2815	serine threonine protein kinase
LK06_RS30780	COG0515	serine threonine protein kinase
LK06_RS30810	COG0328	RNA-DNA hybrid ribonuclease activity
LK06_RS30815	COG2304	oxidoreductase activity
LK06_RS30850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK06_RS30850	COG0515	serine threonine protein kinase
LK06_RS30880	COG1672	PFAM Archaeal ATPase
LK06_RS30880	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LK06_RS30890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK06_RS30940	COG1252	NADH dehydrogenase
LK06_RS30955	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LK06_RS30960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK06_RS30965	COG3281	Trehalose synthase
LK06_RS30975	COG0366	Alpha amylase catalytic
LK06_RS31015	COG0181	hydroxymethylbilane synthase activity
LK06_RS31065	COG0009	L-threonylcarbamoyladenylate synthase
LK06_RS31085	COG2409	Drug exporters of the RND superfamily
LK06_RS31110	COG3001	Fructosamine kinase
LK06_RS31140	COG0583	DNA-binding transcription factor activity
LK06_RS31145	COG3291	Pkd domain containing protein
LK06_RS31170	COG0667	Aldo Keto reductase
LK06_RS31195	COG0438	transferase activity, transferring glycosyl groups
LK06_RS31205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK06_RS31210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK06_RS31215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK06_RS31250	COG1024	Enoyl-CoA hydratase
LK06_RS31250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK06_RS31255	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LK06_RS31265	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LK06_RS31270	COG0298	carbon dioxide binding
LK06_RS31285	COG0375	protein maturation
LK06_RS31310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LK06_RS31345	COG0701	Predicted permease
LK06_RS31360	COG1316	TRANSCRIPTIONal
LK06_RS31375	COG1090	epimerase
LK06_RS31390	COG3511	phospholipase C
LK06_RS31400	COG0456	acetyltransferase
LK06_RS31435	COG0745	RESPONSE REGULATOR receiver
LK06_RS31440	COG2205	protein histidine kinase activity
LK06_RS31445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK06_RS31465	COG3844	kynureninase activity
LK06_RS31475	COG3483	tryptophan 2,3-dioxygenase activity
LK06_RS31480	COG1028	Short-chain dehydrogenase reductase Sdr
LK06_RS31485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK06_RS31495	COG3396	Phenylacetate-CoA oxygenase
LK06_RS31500	COG3460	Phenylacetate-CoA oxygenase
LK06_RS31505	COG3396	Phenylacetate-CoA oxygenase
LK06_RS31515	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS31520	COG0604	alcohol dehydrogenase
LK06_RS31530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK06_RS31540	COG1595	DNA-templated transcription, initiation
LK06_RS31595	COG2208	phosphoserine phosphatase activity
LK06_RS31595	COG2172	sigma factor antagonist activity
LK06_RS31595	COG1366	Belongs to the anti-sigma-factor antagonist family
LK06_RS31605	COG0588	phosphoglycerate mutase activity
LK06_RS31610	COG1070	Carbohydrate kinase
LK06_RS31615	COG1070	Carbohydrate kinase
LK06_RS31630	COG4213	ABC transporter substrate-binding protein
LK06_RS31635	COG1349	DNA-binding transcription factor activity
LK06_RS31650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK06_RS31665	COG1280	lysine exporter protein (LysE YggA)
LK06_RS31680	COG1309	transcriptional regulator
LK06_RS31715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK06_RS31780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK06_RS31795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LK06_RS31800	COG0022	dehydrogenase e1 component
LK06_RS31835	COG0583	DNA-binding transcription factor activity
LK06_RS31855	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LK06_RS31855	COG0321	lipoyl(octanoyl) transferase activity
LK06_RS31885	COG2197	response regulator
LK06_RS31905	COG0318	PFAM AMP-dependent synthetase and ligase
LK06_RS31915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK06_RS31925	COG1131	(ABC) transporter
LK06_RS31965	COG3511	phospholipase C
LK06_RS32005	COG1869	D-ribose catabolic process
LK06_RS32010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK06_RS32020	COG1129	ABC transporter
LK06_RS32045	COG2197	response regulator
LK06_RS32070	COG0602	queuosine metabolic process
LK06_RS32075	COG0720	synthase
LK06_RS32080	COG0302	gtp cyclohydrolase
LK06_RS32100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK06_RS32105	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LK06_RS32115	COG4865	methylaspartate mutase activity
LK06_RS32150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK06_RS32160	COG2801	Transposase and inactivated derivatives
LK06_RS32205	COG4974	Belongs to the 'phage' integrase family
LK06_RS32220	COG1674	ftsk spoiiie
LK06_RS32230	COG2188	Transcriptional regulator
LK06_RS32275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK06_RS32300	COG1695	Transcriptional regulator
LK06_RS32310	COG3328	transposase activity
LK06_RS32410	COG3547	Transposase (IS116 IS110 IS902 family)