locus-tag	class	description
LK07_RS00020	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS00115	COG3328	transposase activity
LK07_RS00120	COG1695	Transcriptional regulator
LK07_RS00145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK07_RS00155	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS00165	COG0515	serine threonine protein kinase
LK07_RS00170	COG0443	Heat shock 70 kDa protein
LK07_RS00200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LK07_RS00215	COG3848	Pyruvate phosphate dikinase
LK07_RS00215	COG0574	Belongs to the PEP-utilizing enzyme family
LK07_RS00245	COG0028	Belongs to the TPP enzyme family
LK07_RS00340	COG4260	virion core protein, lumpy skin disease virus
LK07_RS00355	COG1522	sequence-specific DNA binding
LK07_RS00380	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LK07_RS00385	COG0714	Associated with various cellular activities
LK07_RS00395	COG4106	trans-aconitate 2-methyltransferase activity
LK07_RS00420	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS00425	COG3226	Transcriptional regulator
LK07_RS00440	COG2197	response regulator
LK07_RS00445	COG4585	Histidine kinase
LK07_RS00450	COG2409	Drug exporters of the RND superfamily
LK07_RS00505	COG1414	Transcriptional regulator
LK07_RS00510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK07_RS00545	COG0583	DNA-binding transcription factor activity
LK07_RS00595	COG0683	leucine binding
LK07_RS00600	COG2508	Transcriptional regulator
LK07_RS00600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LK07_RS00625	COG0395	ABC-type sugar transport system, permease component
LK07_RS00630	COG1063	alcohol dehydrogenase
LK07_RS00645	COG4977	sequence-specific DNA binding
LK07_RS00655	COG3634	alkyl hydroperoxide reductase activity
LK07_RS00670	COG1131	(ABC) transporter
LK07_RS00695	COG3511	phospholipase C
LK07_RS00800	COG2271	Major facilitator Superfamily
LK07_RS00850	COG0326	Molecular chaperone. Has ATPase activity
LK07_RS00865	COG1271	oxidase subunit
LK07_RS00875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LK07_RS00880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LK07_RS00905	COG2824	Alkylphosphonate utilization operon protein PhnA
LK07_RS00910	COG0659	secondary active sulfate transmembrane transporter activity
LK07_RS00945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LK07_RS00950	COG4716	Myosin-crossreactive antigen
LK07_RS00955	COG2132	Multicopper oxidase
LK07_RS00990	COG1131	(ABC) transporter
LK07_RS01035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK07_RS01035	COG4651	solute:proton antiporter activity
LK07_RS01055	COG0789	Transcriptional regulator
LK07_RS01060	COG2267	carboxylic ester hydrolase activity
LK07_RS01065	COG2233	PERMEase
LK07_RS01080	COG2130	NADP-dependent
LK07_RS01085	COG4977	sequence-specific DNA binding
LK07_RS01100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK07_RS01105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK07_RS01120	COG2267	carboxylic ester hydrolase activity
LK07_RS01130	COG0559	Belongs to the binding-protein-dependent transport system permease family
LK07_RS01155	COG0789	Transcriptional regulator
LK07_RS01160	COG0659	secondary active sulfate transmembrane transporter activity
LK07_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS01180	COG3835	regulator
LK07_RS01185	COG2409	Drug exporters of the RND superfamily
LK07_RS01195	COG0516	GMP reductase activity
LK07_RS01195	COG0517	IMP dehydrogenase activity
LK07_RS01215	COG0574	Belongs to the PEP-utilizing enzyme family
LK07_RS01215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK07_RS01230	COG1063	alcohol dehydrogenase
LK07_RS01255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LK07_RS01275	COG0517	IMP dehydrogenase activity
LK07_RS01275	COG0617	tRNA 3'-terminal CCA addition
LK07_RS01275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LK07_RS01320	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
LK07_RS01325	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
LK07_RS01360	COG0517	IMP dehydrogenase activity
LK07_RS01365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK07_RS01370	COG0569	domain protein
LK07_RS01430	COG0517	IMP dehydrogenase activity
LK07_RS01430	COG0516	GMP reductase activity
LK07_RS01440	COG1215	transferase activity, transferring glycosyl groups
LK07_RS01450	COG1846	Transcriptional regulator
LK07_RS01450	COG1940	carbohydrate kinase activity
LK07_RS01475	COG1940	carbohydrate kinase activity
LK07_RS01490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK07_RS01495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LK07_RS01500	COG0022	dehydrogenase e1 component
LK07_RS01500	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK07_RS01505	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK07_RS01525	COG1597	lipid kinase activity
LK07_RS01530	COG0277	FAD linked oxidase domain protein
LK07_RS01570	COG3979	chitinase
LK07_RS01575	COG0531	amino acid
LK07_RS01590	COG0038	chloride channel
LK07_RS01605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK07_RS01615	COG1032	radical SAM domain protein
LK07_RS01650	COG0726	polysaccharide deacetylase
LK07_RS01660	COG2837	iron assimilation
LK07_RS01705	COG0667	Aldo Keto reductase
LK07_RS01740	COG3469	chitinase activity
LK07_RS01750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LK07_RS01830	COG0667	Aldo Keto reductase
LK07_RS01885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK07_RS01910	COG3290	protein histidine kinase activity
LK07_RS01915	COG3387	PFAM Glycoside hydrolase 15-related
LK07_RS01925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LK07_RS01960	COG1072	(Pantothenic acid kinase))
LK07_RS01985	COG1309	transcriptional regulator
LK07_RS02015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK07_RS02055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK07_RS02065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LK07_RS02095	COG0515	serine threonine protein kinase
LK07_RS02105	COG1132	(ABC) transporter
LK07_RS02110	COG1132	(ABC) transporter
LK07_RS02115	COG2197	response regulator
LK07_RS02150	COG4221	oxidoreductase activity
LK07_RS02190	COG0662	Cupin 2, conserved barrel domain protein
LK07_RS02205	COG1595	DNA-templated transcription, initiation
LK07_RS02230	COG0667	Aldo Keto reductase
LK07_RS02265	COG2124	cytochrome p450
LK07_RS02320	COG2124	cytochrome p450
LK07_RS02320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LK07_RS02350	COG1309	transcriptional regulator
LK07_RS02385	COG0247	lactate metabolic process
LK07_RS02390	COG1139	Iron-sulfur cluster binding protein
LK07_RS02395	COG1556	Lactate utilization protein
LK07_RS02400	COG0542	response to heat
LK07_RS02430	COG1309	transcriptional regulator
LK07_RS02495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK07_RS02505	COG0076	glutamate decarboxylase activity
LK07_RS02515	COG0671	phosphoesterase, PA-phosphatase related
LK07_RS02520	COG0745	RESPONSE REGULATOR receiver
LK07_RS02525	COG2205	protein histidine kinase activity
LK07_RS02545	COG0411	ABC transporter
LK07_RS02560	COG0242	peptide deformylase activity
LK07_RS02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK07_RS02575	COG1609	Transcriptional regulator
LK07_RS02600	COG2268	Band 7 protein
LK07_RS02625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK07_RS02630	COG0121	glutamine amidotransferase
LK07_RS02635	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LK07_RS02640	COG2182	Extracellular solute-binding protein
LK07_RS02645	COG3360	Dodecin
LK07_RS02675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LK07_RS02680	COG1053	succinate dehydrogenase
LK07_RS02735	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK07_RS02735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK07_RS02745	COG0531	amino acid
LK07_RS02770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK07_RS02805	COG0395	ABC-type sugar transport system, permease component
LK07_RS02810	COG1175	transmembrane transport
LK07_RS02820	COG1609	Transcriptional regulator
LK07_RS02845	COG3537	Alpha-1,2-mannosidase
LK07_RS02865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LK07_RS02875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LK07_RS02895	COG1201	RNA secondary structure unwinding
LK07_RS02990	COG0142	geranyltranstransferase activity
LK07_RS03000	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LK07_RS03010	COG4221	oxidoreductase activity
LK07_RS03025	COG3046	protein related to deoxyribodipyrimidine photolyase
LK07_RS03035	COG0702	epimerase
LK07_RS03040	COG1357	PFAM Pentapeptide repeats (8 copies)
LK07_RS03135	COG1132	(ABC) transporter
LK07_RS03145	COG1024	Enoyl-CoA hydratase
LK07_RS03155	COG0668	transmembrane transport
LK07_RS03160	COG2838	Isocitrate dehydrogenase
LK07_RS03165	COG2124	cytochrome p450
LK07_RS03220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK07_RS03225	COG3938	Belongs to the proline racemase family
LK07_RS03235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK07_RS03240	COG0586	Pfam SNARE associated Golgi protein
LK07_RS03260	COG1960	acyl-CoA dehydrogenase activity
LK07_RS03265	COG1960	acyl-CoA dehydrogenase activity
LK07_RS03275	COG1793	dna ligase
LK07_RS03285	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS03295	COG3424	synthase
LK07_RS03300	COG2124	cytochrome p450
LK07_RS03315	COG1960	acyl-CoA dehydrogenase activity
LK07_RS03325	COG0242	peptide deformylase activity
LK07_RS03335	COG3442	glutamine amidotransferase
LK07_RS03340	COG0205	6-phosphofructokinase activity
LK07_RS03355	COG1522	sequence-specific DNA binding
LK07_RS03360	COG1834	amidinotransferase
LK07_RS03365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK07_RS03370	COG0204	Acyl-transferase
LK07_RS03380	COG0829	nickel cation binding
LK07_RS03385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LK07_RS03390	COG0830	nickel cation binding
LK07_RS03395	COG0804	urea catabolic process
LK07_RS03400	COG0832	Belongs to the urease beta subunit family
LK07_RS03405	COG0831	urea catabolic process
LK07_RS03420	COG0740	serine-type endopeptidase activity
LK07_RS03455	COG0156	8-amino-7-oxononanoate synthase activity
LK07_RS03460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LK07_RS03465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK07_RS03470	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LK07_RS03480	COG2226	methyltransferase
LK07_RS03535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK07_RS03555	COG2124	cytochrome p450
LK07_RS03585	COG0604	alcohol dehydrogenase
LK07_RS03585	COG3321	synthase
LK07_RS03650	COG1917	Cupin 2, conserved barrel domain protein
LK07_RS03650	COG4977	sequence-specific DNA binding
LK07_RS03680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK07_RS03700	COG4977	sequence-specific DNA binding
LK07_RS03700	COG1917	Cupin 2, conserved barrel domain protein
LK07_RS03720	COG0477	Major facilitator Superfamily
LK07_RS03730	COG3251	PFAM MbtH domain protein
LK07_RS03740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS03750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK07_RS03755	COG2072	flavoprotein involved in K transport
LK07_RS03780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS03785	COG3251	PFAM MbtH domain protein
LK07_RS03805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LK07_RS03810	COG0277	FAD linked oxidase domain protein
LK07_RS03825	COG0243	molybdopterin cofactor binding
LK07_RS03830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS03845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK07_RS03850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK07_RS03860	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LK07_RS03870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS03900	COG1132	(ABC) transporter
LK07_RS03915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK07_RS03930	COG1940	carbohydrate kinase activity
LK07_RS03950	COG0596	Alpha beta hydrolase
LK07_RS03965	COG0626	cystathionine gamma-synthase activity
LK07_RS04015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK07_RS04040	COG0419	ATPase involved in DNA repair
LK07_RS04045	COG0420	3'-5' exonuclease activity
LK07_RS04050	COG1739	Uncharacterized protein family UPF0029
LK07_RS04065	COG1832	CoA-binding protein
LK07_RS04070	COG0531	amino acid
LK07_RS04075	COG0640	Transcriptional regulator
LK07_RS04090	COG0110	maltose O-acetyltransferase activity
LK07_RS04115	COG1819	glycosyl
LK07_RS04140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK07_RS04165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK07_RS04175	COG2267	carboxylic ester hydrolase activity
LK07_RS04190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LK07_RS04210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK07_RS04215	COG0747	negative chemotaxis
LK07_RS04290	COG3631	Ketosteroid isomerase-related protein
LK07_RS04295	COG0702	epimerase
LK07_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS04330	COG2124	cytochrome p450
LK07_RS04340	COG0017	Asparaginyl-tRNA synthetase
LK07_RS04345	COG0277	FAD linked oxidase domain protein
LK07_RS04350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS04365	COG2226	methyltransferase
LK07_RS04375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS04405	COG0697	spore germination
LK07_RS04625	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK07_RS04640	COG0384	phenazine biosynthesis protein PhzF
LK07_RS04695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK07_RS04695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK07_RS04705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK07_RS04725	COG1716	ATPase activity
LK07_RS04745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK07_RS04780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK07_RS04790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK07_RS04820	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS04840	COG2018	Roadblock/LC7 domain
LK07_RS04870	COG1984	allophanate hydrolase subunit 2
LK07_RS04875	COG2755	lipolytic protein G-D-S-L family
LK07_RS04880	COG0438	transferase activity, transferring glycosyl groups
LK07_RS04885	COG0438	transferase activity, transferring glycosyl groups
LK07_RS04915	COG2364	Membrane
LK07_RS04925	COG2270	Major facilitator Superfamily
LK07_RS04935	COG3030	protein affecting phage T7 exclusion by the F plasmid
LK07_RS04940	COG1216	Glycosyl transferase, family 2
LK07_RS04965	COG1960	acyl-CoA dehydrogenase activity
LK07_RS05015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LK07_RS05020	COG0140	phosphoribosyl-ATP diphosphatase activity
LK07_RS05025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LK07_RS05030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK07_RS05030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK07_RS05035	COG3201	nicotinamide mononucleotide transporter
LK07_RS05045	COG0702	epimerase
LK07_RS05070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK07_RS05090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK07_RS05095	COG3842	ATPase activity
LK07_RS05115	COG2186	Transcriptional regulator
LK07_RS05130	COG2390	Transcriptional regulator
LK07_RS05135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LK07_RS05145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK07_RS05160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LK07_RS05175	COG0194	GDP metabolic process
LK07_RS05185	COG0284	orotidine-5'-phosphate decarboxylase activity
LK07_RS05190	COG0167	dihydroorotate dehydrogenase activity
LK07_RS05195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LK07_RS05200	COG0505	Belongs to the CarA family
LK07_RS05210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK07_RS05215	COG0540	Belongs to the ATCase OTCase family
LK07_RS05220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LK07_RS05230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK07_RS05235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK07_RS05240	COG0006	proline dipeptidase activity
LK07_RS05250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LK07_RS05255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LK07_RS05260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LK07_RS05265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LK07_RS05275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LK07_RS05280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK07_RS05295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LK07_RS05315	COG0124	histidyl-tRNA synthetase
LK07_RS05325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK07_RS05330	COG1196	nuclear chromosome segregation
LK07_RS05335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK07_RS05345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK07_RS05350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK07_RS05355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK07_RS05365	COG2255	four-way junction helicase activity
LK07_RS05370	COG0632	four-way junction helicase activity
LK07_RS05375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LK07_RS05385	COG0217	transcriptional regulatory protein
LK07_RS05390	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LK07_RS05395	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LK07_RS05405	COG0438	transferase activity, transferring glycosyl groups
LK07_RS05410	COG1560	Kdo2-lipid A biosynthetic process
LK07_RS05415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LK07_RS05435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK07_RS05440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LK07_RS05455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LK07_RS05595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LK07_RS05650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK07_RS05650	COG1648	precorrin-2 dehydrogenase activity
LK07_RS05655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LK07_RS05670	COG1464	Belongs to the NlpA lipoprotein family
LK07_RS05675	COG2011	ABC-type metal ion transport system permease component
LK07_RS05680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK07_RS05710	COG0204	Acyl-transferase
LK07_RS05710	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS05715	COG0477	Major facilitator Superfamily
LK07_RS05730	COG0165	Argininosuccinate lyase
LK07_RS05740	COG2205	protein histidine kinase activity
LK07_RS05745	COG0745	RESPONSE REGULATOR receiver
LK07_RS05775	COG1438	arginine binding
LK07_RS05780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK07_RS05785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK07_RS05790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LK07_RS05795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LK07_RS05810	COG0463	Glycosyl transferase, family 2
LK07_RS05845	COG1649	PFAM Uncharacterised BCR, COG1649
LK07_RS05875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK07_RS05875	COG0072	phenylalanine-tRNA ligase activity
LK07_RS05880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LK07_RS05885	COG5002	protein histidine kinase activity
LK07_RS05890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK07_RS05895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LK07_RS05900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LK07_RS05905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LK07_RS05950	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS05955	COG0174	glutamine synthetase
LK07_RS05960	COG2186	Transcriptional regulator
LK07_RS05965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK07_RS05980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LK07_RS05990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK07_RS06005	COG0564	pseudouridine synthase activity
LK07_RS06040	COG0805	protein transport
LK07_RS06045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK07_RS06080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK07_RS06090	COG1609	Transcriptional regulator
LK07_RS06095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK07_RS06100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK07_RS06115	COG4122	O-methyltransferase activity
LK07_RS06120	COG1222	aaa ATPase
LK07_RS06145	COG1994	Peptidase M50
LK07_RS06145	COG0517	IMP dehydrogenase activity
LK07_RS06160	COG2197	response regulator
LK07_RS06165	COG0747	negative chemotaxis
LK07_RS06170	COG0747	negative chemotaxis
LK07_RS06180	COG1410	methionine synthase
LK07_RS06180	COG0646	methionine synthase
LK07_RS06185	COG1414	Transcriptional regulator
LK07_RS06190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK07_RS06195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK07_RS06200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LK07_RS06205	COG2186	Transcriptional regulator
LK07_RS06215	COG0215	cysteine-tRNA ligase activity
LK07_RS06235	COG0598	Magnesium transport protein CorA
LK07_RS06245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK07_RS06250	COG0667	Aldo Keto reductase
LK07_RS06280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK07_RS06290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LK07_RS06290	COG1796	DNA polymerase
LK07_RS06310	COG3012	SEC-C Motif Domain Protein
LK07_RS06315	COG2186	Transcriptional regulator
LK07_RS06320	COG3265	gluconokinase activity
LK07_RS06350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LK07_RS06355	COG2149	membrane
LK07_RS06380	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS06425	COG1960	acyl-CoA dehydrogenase activity
LK07_RS06435	COG0640	Transcriptional regulator
LK07_RS06440	COG0697	spore germination
LK07_RS06455	COG0243	molybdopterin cofactor binding
LK07_RS06470	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LK07_RS06475	COG2188	Transcriptional regulator
LK07_RS06500	COG1595	DNA-templated transcription, initiation
LK07_RS06525	COG2755	lipolytic protein G-D-S-L family
LK07_RS06545	COG0726	polysaccharide deacetylase
LK07_RS06570	COG1725	Transcriptional regulator
LK07_RS06585	COG2226	methyltransferase
LK07_RS06600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LK07_RS06605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK07_RS06610	COG0587	DNA-directed DNA polymerase activity
LK07_RS06630	COG0542	response to heat
LK07_RS06640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK07_RS06645	COG0587	DNA-directed DNA polymerase activity
LK07_RS06670	COG1799	cell septum assembly
LK07_RS06675	COG1960	acyl-CoA dehydrogenase activity
LK07_RS06680	COG0477	Major facilitator Superfamily
LK07_RS06695	COG0671	phosphoesterase, PA-phosphatase related
LK07_RS06705	COG3583	domain protein
LK07_RS06720	COG1160	GTP binding
LK07_RS06730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LK07_RS06750	COG3541	Predicted nucleotidyltransferase
LK07_RS06765	COG1187	pseudouridine synthase activity
LK07_RS06770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LK07_RS06775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LK07_RS06790	COG0686	Belongs to the AlaDH PNT family
LK07_RS06800	COG0494	nUDIX hydrolase
LK07_RS06805	COG0504	CTP synthase activity
LK07_RS06815	COG3387	PFAM Glycoside hydrolase 15-related
LK07_RS06840	COG0497	DNA recombination
LK07_RS06845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LK07_RS06865	COG1120	ATPase activity
LK07_RS06870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK07_RS06875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK07_RS06880	COG0647	UMP catabolic process
LK07_RS06915	COG2094	Belongs to the DNA glycosylase MPG family
LK07_RS06965	COG1881	PFAM PEBP family protein
LK07_RS06985	COG1119	ATPase activity
LK07_RS07005	COG2197	response regulator
LK07_RS07010	COG4585	Histidine kinase
LK07_RS07020	COG0842	Transport permease protein
LK07_RS07020	COG1716	ATPase activity
LK07_RS07020	COG1131	(ABC) transporter
LK07_RS07030	COG0560	Phosphoserine phosphatase
LK07_RS07030	COG3830	Belongs to the UPF0237 family
LK07_RS07035	COG0588	phosphoglycerate mutase activity
LK07_RS07050	COG2807	transmembrane transport
LK07_RS07055	COG2186	Transcriptional regulator
LK07_RS07115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LK07_RS07135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LK07_RS07140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK07_RS07160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK07_RS07165	COG1063	alcohol dehydrogenase
LK07_RS07205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK07_RS07220	COG3387	PFAM Glycoside hydrolase 15-related
LK07_RS07255	COG1302	Protein conserved in bacteria
LK07_RS07265	COG1024	Enoyl-CoA hydratase
LK07_RS07275	COG0488	(ABC) transporter
LK07_RS07295	COG0235	Class ii aldolase
LK07_RS07320	COG1492	cobalamin metabolic process
LK07_RS07335	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LK07_RS07340	COG1797	cobyrinic acid a,c-diamide synthase activity
LK07_RS07400	COG0765	amino acid transport
LK07_RS07410	COG0456	acetyltransferase
LK07_RS07415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK07_RS07420	COG1917	Cupin 2, conserved barrel domain protein
LK07_RS07425	COG5285	phytanoyl-CoA dioxygenase
LK07_RS07450	COG1414	Transcriptional regulator
LK07_RS07480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK07_RS07515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK07_RS07520	COG2171	N-acyltransferase activity
LK07_RS07525	COG2076	Multidrug Resistance protein
LK07_RS07535	COG2151	metal-sulfur cluster biosynthetic enzyme
LK07_RS07540	COG0822	iron-sulfur transferase activity
LK07_RS07545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK07_RS07550	COG0396	ATPase activity
LK07_RS07560	COG0719	Fe-S assembly protein
LK07_RS07575	COG2746	aminoglycoside 3-N-acetyltransferase activity
LK07_RS07580	COG1131	(ABC) transporter
LK07_RS07590	COG1612	heme a metabolic process
LK07_RS07610	COG0109	protoheme IX farnesyltransferase activity
LK07_RS07620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK07_RS07625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK07_RS07640	COG0363	glucosamine-6-phosphate deaminase activity
LK07_RS07645	COG0395	ABC-type sugar transport system, permease component
LK07_RS07650	COG1175	transmembrane transport
LK07_RS07655	COG1653	transport
LK07_RS07660	COG0366	Alpha amylase catalytic
LK07_RS07665	COG1653	transport
LK07_RS07670	COG1695	Transcriptional regulator
LK07_RS07675	COG0577	efflux transmembrane transporter activity
LK07_RS07675	COG1136	(ABC) transporter
LK07_RS07685	COG0166	Belongs to the GPI family
LK07_RS07695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK07_RS07700	COG0149	triose-phosphate isomerase activity
LK07_RS07705	COG0126	phosphoglycerate kinase activity
LK07_RS07710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK07_RS07715	COG1481	regulation of sporulation
LK07_RS07720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK07_RS07725	COG1660	Displays ATPase and GTPase activities
LK07_RS07730	COG0322	excinuclease ABC activity
LK07_RS07745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK07_RS07750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK07_RS07765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LK07_RS07775	COG0387	Pfam Sodium calcium exchanger
LK07_RS07790	COG0556	nucleotide-excision repair
LK07_RS07800	COG0584	glycerophosphoryl diester phosphodiesterase
LK07_RS07805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK07_RS07815	COG2313	pseudouridylate synthase activity
LK07_RS07820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LK07_RS07820	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LK07_RS07825	COG2226	methyltransferase
LK07_RS07830	COG0598	Magnesium transport protein CorA
LK07_RS07900	COG1289	transmembrane transporter activity
LK07_RS07925	COG0237	dephospho-CoA kinase activity
LK07_RS07935	COG0539	negative regulation of cytoplasmic translation
LK07_RS07945	COG1643	Atp-dependent helicase
LK07_RS07980	COG2050	protein possibly involved in aromatic compounds catabolism
LK07_RS07985	COG0683	leucine binding
LK07_RS08045	COG1605	Chorismate mutase
LK07_RS08045	COG0287	Prephenate dehydrogenase
LK07_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS08070	COG1024	Enoyl-CoA hydratase
LK07_RS08090	COG0183	Belongs to the thiolase family
LK07_RS08095	COG1309	transcriptional regulator
LK07_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS08105	COG1960	acyl-CoA dehydrogenase activity
LK07_RS08115	COG2304	oxidoreductase activity
LK07_RS08125	COG0067	glutamate synthase
LK07_RS08125	COG0069	glutamate synthase activity
LK07_RS08125	COG0070	glutamate synthase
LK07_RS08135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK07_RS08140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LK07_RS08150	COG0159	tryptophan synthase activity
LK07_RS08155	COG0133	tryptophan synthase activity
LK07_RS08165	COG0134	indole-3-glycerol-phosphate synthase activity
LK07_RS08195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LK07_RS08205	COG0346	lactoylglutathione lyase activity
LK07_RS08210	COG0107	imidazoleglycerol-phosphate synthase activity
LK07_RS08215	COG0251	oxidation-reduction process
LK07_RS08220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LK07_RS08225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LK07_RS08230	COG0131	Imidazoleglycerol-phosphate dehydratase
LK07_RS08235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK07_RS08240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LK07_RS08255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK07_RS08275	COG1432	Conserved Protein
LK07_RS08280	COG0587	DNA-directed DNA polymerase activity
LK07_RS08330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LK07_RS08345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LK07_RS08350	COG3599	regulation of cell shape
LK07_RS08360	COG1799	cell septum assembly
LK07_RS08370	COG1496	oxidoreductase activity
LK07_RS08375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LK07_RS08385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK07_RS08395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LK07_RS08400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK07_RS08405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LK07_RS08410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LK07_RS08425	COG0275	rRNA processing
LK07_RS08435	COG0714	Associated with various cellular activities
LK07_RS08455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK07_RS08470	COG1511	domain protein
LK07_RS08475	COG1309	transcriptional regulator
LK07_RS08495	COG0352	thiamine-phosphate diphosphorylase activity
LK07_RS08505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK07_RS08515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK07_RS08515	COG2022	thiamine diphosphate biosynthetic process
LK07_RS08525	COG2022	thiamine diphosphate biosynthetic process
LK07_RS08530	COG0515	serine threonine protein kinase
LK07_RS08530	COG2815	serine threonine protein kinase
LK07_RS08535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LK07_RS08540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LK07_RS08545	COG2193	ferroxidase activity
LK07_RS08550	COG0243	molybdopterin cofactor binding
LK07_RS08555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LK07_RS08565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LK07_RS08570	COG0205	6-phosphofructokinase activity
LK07_RS08580	COG4585	Histidine kinase
LK07_RS08610	COG1940	carbohydrate kinase activity
LK07_RS08620	COG0003	Pfam Anion-transporting ATPase
LK07_RS08645	COG0438	transferase activity, transferring glycosyl groups
LK07_RS08660	COG3883	PFAM NLP P60 protein
LK07_RS08660	COG0791	NLP P60 protein
LK07_RS08690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK07_RS08695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK07_RS08700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LK07_RS08705	COG0723	plastoquinol--plastocyanin reductase activity
LK07_RS08710	COG2010	Cytochrome c
LK07_RS08715	COG1845	cytochrome c oxidase, subunit III
LK07_RS08725	COG1376	ErfK ybiS ycfS ynhG family protein
LK07_RS08735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK07_RS08740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LK07_RS08750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK07_RS08780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LK07_RS08785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK07_RS08790	COG2197	response regulator
LK07_RS08795	COG4585	Histidine kinase
LK07_RS08835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LK07_RS08840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK07_RS08840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK07_RS08855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LK07_RS08865	COG0438	transferase activity, transferring glycosyl groups
LK07_RS08875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LK07_RS08880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK07_RS08885	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK07_RS08895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LK07_RS08940	COG0321	lipoyl(octanoyl) transferase activity
LK07_RS08945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LK07_RS08985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK07_RS08990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK07_RS09005	COG2329	Antibiotic biosynthesis monooxygenase
LK07_RS09020	COG0174	glutamine synthetase
LK07_RS09030	COG2226	methyltransferase
LK07_RS09045	COG0477	Major facilitator Superfamily
LK07_RS09080	COG2124	cytochrome p450
LK07_RS09085	COG0501	Belongs to the peptidase M48B family
LK07_RS09165	COG1309	transcriptional regulator
LK07_RS09185	COG0366	Alpha amylase catalytic
LK07_RS09190	COG3833	ABC-type maltose transport systems, permease component
LK07_RS09195	COG1175	transmembrane transport
LK07_RS09205	COG1609	Transcriptional regulator
LK07_RS09215	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LK07_RS09220	COG3511	phospholipase C
LK07_RS09225	COG0174	glutamine synthetase
LK07_RS09240	COG1959	2 iron, 2 sulfur cluster binding
LK07_RS09260	COG2814	Major facilitator Superfamily
LK07_RS09310	COG0477	Major facilitator Superfamily
LK07_RS09315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LK07_RS09335	COG1994	Peptidase M50
LK07_RS09380	COG2822	iron ion transport
LK07_RS09385	COG2837	iron assimilation
LK07_RS09390	COG0672	)-iron permease
LK07_RS09410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK07_RS09415	COG2814	Major facilitator Superfamily
LK07_RS09425	COG1686	Belongs to the peptidase S11 family
LK07_RS09445	COG1404	Belongs to the peptidase S8 family
LK07_RS09500	COG3022	response to hydroperoxide
LK07_RS09505	COG0800	Aldolase
LK07_RS09520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LK07_RS09545	COG2030	dehydratase
LK07_RS09550	COG4585	Histidine kinase
LK07_RS09555	COG2197	response regulator
LK07_RS09560	COG0183	Belongs to the thiolase family
LK07_RS09570	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK07_RS09580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK07_RS09595	COG0438	transferase activity, transferring glycosyl groups
LK07_RS09600	COG1309	transcriptional regulator
LK07_RS09680	COG3845	ABC transporter
LK07_RS09695	COG3619	membrane
LK07_RS09700	COG2124	cytochrome p450
LK07_RS09705	COG0183	Belongs to the thiolase family
LK07_RS09715	COG4122	O-methyltransferase activity
LK07_RS09740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK07_RS09760	COG0483	inositol monophosphate 1-phosphatase activity
LK07_RS09825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK07_RS09840	COG1358	cellular component organization or biogenesis
LK07_RS09885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LK07_RS09890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LK07_RS09895	COG0477	Major facilitator Superfamily
LK07_RS09900	COG1309	transcriptional regulator
LK07_RS09915	COG0789	Transcriptional regulator
LK07_RS09930	COG1741	Belongs to the pirin family
LK07_RS09945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK07_RS09950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK07_RS09955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK07_RS09980	COG2130	NADP-dependent
LK07_RS09985	COG1764	response to oxidative stress
LK07_RS09995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK07_RS10040	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS10045	COG0825	malonyl-CoA metabolic process
LK07_RS10045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LK07_RS10050	COG1077	Cell shape determining protein MreB Mrl
LK07_RS10065	COG4213	ABC transporter substrate-binding protein
LK07_RS10245	COG1070	Carbohydrate kinase
LK07_RS10260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK07_RS10270	COG0358	DNA primase activity
LK07_RS10280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LK07_RS10295	COG0243	molybdopterin cofactor binding
LK07_RS10315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK07_RS10320	COG2146	nitrite reductase [NAD(P)H] activity
LK07_RS10320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK07_RS10335	COG0574	Belongs to the PEP-utilizing enzyme family
LK07_RS10335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK07_RS10340	COG1940	carbohydrate kinase activity
LK07_RS10340	COG1846	Transcriptional regulator
LK07_RS10345	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LK07_RS10375	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS10380	COG0423	glycine-tRNA ligase activity
LK07_RS10385	COG3443	Belongs to the bacterial solute-binding protein 9 family
LK07_RS10385	COG0803	Belongs to the bacterial solute-binding protein 9 family
LK07_RS10390	COG1121	(ABC) transporter
LK07_RS10395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LK07_RS10405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK07_RS10410	COG1381	Involved in DNA repair and RecF pathway recombination
LK07_RS10425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK07_RS10435	COG1136	(ABC) transporter
LK07_RS10445	COG4585	Histidine kinase
LK07_RS10450	COG2197	response regulator
LK07_RS10460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK07_RS10485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LK07_RS10520	COG1619	proteins homologs of microcin C7 resistance protein MccF
LK07_RS10525	COG2315	Protein conserved in bacteria
LK07_RS10535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LK07_RS10545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK07_RS10555	COG1234	tRNA 3'-trailer cleavage
LK07_RS10560	COG0537	adenosine 5'-monophosphoramidase activity
LK07_RS10565	COG4946	Tricorn protease homolog
LK07_RS10565	COG0793	Belongs to the peptidase S41A family
LK07_RS10585	COG0484	heat shock protein binding
LK07_RS10590	COG1420	regulation of RNA biosynthetic process
LK07_RS10620	COG0481	GTPase activity
LK07_RS10625	COG0268	Binds directly to 16S ribosomal RNA
LK07_RS10645	COG1234	tRNA 3'-trailer cleavage
LK07_RS10650	COG1596	polysaccharide export
LK07_RS10650	COG1555	photosystem II stabilization
LK07_RS10655	COG1307	EDD domain protein, DegV family
LK07_RS10665	COG0495	leucyl-tRNA aminoacylation
LK07_RS10675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LK07_RS10695	COG0588	phosphoglycerate mutase activity
LK07_RS10710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LK07_RS10725	COG0501	Belongs to the peptidase M48B family
LK07_RS10740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LK07_RS10755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LK07_RS10780	COG3328	transposase activity
LK07_RS10820	COG0582	viral genome integration into host DNA
LK07_RS10865	COG4974	Belongs to the 'phage' integrase family
LK07_RS10890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LK07_RS10895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LK07_RS10900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LK07_RS10905	COG0371	Dehydrogenase
LK07_RS10915	COG1530	ribonuclease E activity
LK07_RS10945	COG0772	Belongs to the SEDS family
LK07_RS10950	COG0768	penicillin binding
LK07_RS10965	COG1077	Cell shape determining protein MreB Mrl
LK07_RS10970	COG0105	UTP biosynthetic process
LK07_RS10980	COG0285	dihydrofolate synthase activity
LK07_RS10985	COG0525	valine-tRNA ligase activity
LK07_RS10995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LK07_RS11000	COG0740	serine-type endopeptidase activity
LK07_RS11005	COG0740	serine-type endopeptidase activity
LK07_RS11010	COG0544	peptidyl-prolyl cis-trans isomerase activity
LK07_RS11030	COG3594	Acyltransferase
LK07_RS11050	COG4552	Acetyltransferase involved in intracellular survival and related
LK07_RS11070	COG1113	amino acid transport
LK07_RS11080	COG1113	amino acid transport
LK07_RS11085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LK07_RS11090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK07_RS11135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK07_RS11165	COG1595	DNA-templated transcription, initiation
LK07_RS11175	COG1131	(ABC) transporter
LK07_RS11195	COG0668	transmembrane transport
LK07_RS11210	COG1175	transmembrane transport
LK07_RS11215	COG0395	ABC-type sugar transport system, permease component
LK07_RS11220	COG1486	melibiose metabolic process
LK07_RS11235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK07_RS11265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LK07_RS11305	COG0629	single-stranded DNA binding
LK07_RS11360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK07_RS11365	COG0438	transferase activity, transferring glycosyl groups
LK07_RS11430	COG0438	transferase activity, transferring glycosyl groups
LK07_RS11455	COG0438	transferase activity, transferring glycosyl groups
LK07_RS11480	COG0492	ferredoxin-NADP+ reductase activity
LK07_RS11515	COG1131	(ABC) transporter
LK07_RS11535	COG3962	Belongs to the TPP enzyme family
LK07_RS11540	COG3718	enzyme involved in inositol metabolism
LK07_RS11550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK07_RS11610	COG0582	viral genome integration into host DNA
LK07_RS11640	COG2188	Transcriptional regulator
LK07_RS11705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LK07_RS11735	COG1472	Belongs to the glycosyl hydrolase 3 family
LK07_RS11765	COG0028	Belongs to the TPP enzyme family
LK07_RS11790	COG1946	Acyl-CoA thioesterase
LK07_RS11800	COG1309	transcriptional regulator
LK07_RS11805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK07_RS11815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK07_RS11820	COG1960	acyl-CoA dehydrogenase activity
LK07_RS11840	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LK07_RS11860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK07_RS11870	COG0589	response to stress
LK07_RS11880	COG4977	sequence-specific DNA binding
LK07_RS11885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LK07_RS11920	COG3979	chitinase
LK07_RS11930	COG0745	RESPONSE REGULATOR receiver
LK07_RS11940	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LK07_RS11955	COG0406	alpha-ribazole phosphatase activity
LK07_RS12005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK07_RS12025	COG0154	amidase activity
LK07_RS12035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK07_RS12040	COG0765	amino acid transport
LK07_RS12045	COG0765	amino acid transport
LK07_RS12050	COG1126	abc transporter atp-binding protein
LK07_RS12065	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS12110	COG2188	Transcriptional regulator
LK07_RS12120	COG1940	carbohydrate kinase activity
LK07_RS12125	COG0673	inositol 2-dehydrogenase activity
LK07_RS12130	COG4702	Belongs to the UPF0303 family
LK07_RS12145	COG0706	membrane insertase activity
LK07_RS12155	COG1309	transcriptional regulator
LK07_RS12160	COG1136	(ABC) transporter
LK07_RS12185	COG2733	membrane
LK07_RS12195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LK07_RS12220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK07_RS12250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LK07_RS12255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK07_RS12260	COG1263	PTS System
LK07_RS12265	COG1263	PTS System
LK07_RS12275	COG0463	Glycosyl transferase, family 2
LK07_RS12280	COG1234	tRNA 3'-trailer cleavage
LK07_RS12320	COG1113	amino acid transport
LK07_RS12335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LK07_RS12345	COG1335	isochorismatase
LK07_RS12380	COG0277	FAD linked oxidase domain protein
LK07_RS12390	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LK07_RS12400	COG1174	glycine betaine transport
LK07_RS12405	COG1125	glycine betaine transport
LK07_RS12405	COG0517	IMP dehydrogenase activity
LK07_RS12410	COG1174	glycine betaine transport
LK07_RS12430	COG3480	Lon protease (S16) C-terminal proteolytic domain
LK07_RS12500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LK07_RS12510	COG1678	Uncharacterized ACR, COG1678
LK07_RS12515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK07_RS12525	COG0776	regulation of translation
LK07_RS12535	COG3973	AAA domain
LK07_RS12555	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LK07_RS12560	COG1366	Belongs to the anti-sigma-factor antagonist family
LK07_RS12565	COG1366	Belongs to the anti-sigma-factor antagonist family
LK07_RS12610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK07_RS12630	COG2223	nitrite transmembrane transporter activity
LK07_RS12640	COG0583	DNA-binding transcription factor activity
LK07_RS12660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LK07_RS12665	COG0793	Belongs to the peptidase S41A family
LK07_RS12670	COG2177	Part of the ABC transporter FtsEX involved in
LK07_RS12675	COG2884	Cell division ATP-binding protein ftsE
LK07_RS12690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LK07_RS12695	COG0515	serine threonine protein kinase
LK07_RS12700	COG0515	serine threonine protein kinase
LK07_RS12715	COG1175	transmembrane transport
LK07_RS12720	COG0395	ABC-type sugar transport system, permease component
LK07_RS12725	COG1216	Glycosyl transferase, family 2
LK07_RS12730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LK07_RS12735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LK07_RS12740	COG1764	response to oxidative stress
LK07_RS12745	COG1846	Transcriptional regulator
LK07_RS12780	COG1134	teichoic acid transport
LK07_RS12780	COG1388	LysM domain
LK07_RS12785	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LK07_RS12790	COG1215	transferase activity, transferring glycosyl groups
LK07_RS12800	COG2902	Dehydrogenase
LK07_RS12825	COG0653	protein targeting
LK07_RS12835	COG3214	Protein conserved in bacteria
LK07_RS12840	COG2197	response regulator
LK07_RS12845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LK07_RS12855	COG0823	Involved in the tonB-independent uptake of proteins
LK07_RS12860	COG5000	phosphorelay sensor kinase activity
LK07_RS12860	COG5002	protein histidine kinase activity
LK07_RS12865	COG0745	RESPONSE REGULATOR receiver
LK07_RS12870	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LK07_RS12890	COG0714	Associated with various cellular activities
LK07_RS12935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LK07_RS12950	COG1482	cell wall glycoprotein biosynthetic process
LK07_RS12960	COG2835	tetraacyldisaccharide 4'-kinase activity
LK07_RS12965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK07_RS13005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK07_RS13010	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LK07_RS13010	COG0778	Nitroreductase
LK07_RS13035	COG1316	TRANSCRIPTIONal
LK07_RS13040	COG1316	TRANSCRIPTIONal
LK07_RS13050	COG1316	TRANSCRIPTIONal
LK07_RS13060	COG1316	TRANSCRIPTIONal
LK07_RS13085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LK07_RS13125	COG2205	protein histidine kinase activity
LK07_RS13130	COG0745	RESPONSE REGULATOR receiver
LK07_RS13135	COG3104	oligopeptide transport
LK07_RS13155	COG1366	Belongs to the anti-sigma-factor antagonist family
LK07_RS13160	COG1191	sigma factor activity
LK07_RS13170	COG1228	amidohydrolase
LK07_RS13180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK07_RS13185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LK07_RS13230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK07_RS13235	COG1072	(Pantothenic acid kinase))
LK07_RS13240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK07_RS13245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LK07_RS13250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LK07_RS13260	COG0101	tRNA pseudouridine synthase activity
LK07_RS13265	COG0203	ribosomal protein L17
LK07_RS13270	COG0202	RNA polymerase activity
LK07_RS13275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LK07_RS13280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LK07_RS13285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK07_RS13290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK07_RS13300	COG0563	adenylate kinase activity
LK07_RS13310	COG0200	Binds to the 23S rRNA
LK07_RS13315	COG1841	ribosomal large subunit assembly
LK07_RS13320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LK07_RS13325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LK07_RS13330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LK07_RS13335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LK07_RS13345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LK07_RS13350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LK07_RS13355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LK07_RS13360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LK07_RS13365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LK07_RS13370	COG0255	Belongs to the universal ribosomal protein uL29 family
LK07_RS13375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LK07_RS13380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LK07_RS13385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LK07_RS13390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LK07_RS13395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LK07_RS13400	COG0089	rRNA binding
LK07_RS13405	COG0088	Forms part of the polypeptide exit tunnel
LK07_RS13410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LK07_RS13415	COG0051	transcription antitermination factor activity, RNA binding
LK07_RS13435	COG2885	chlorophyll binding
LK07_RS13480	COG1115	amino acid carrier protein
LK07_RS13485	COG3835	regulator
LK07_RS13500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK07_RS13505	COG0049	tRNA binding
LK07_RS13510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LK07_RS13515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LK07_RS13520	COG0085	RNA polymerase activity
LK07_RS13545	COG0081	regulation of translation
LK07_RS13550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LK07_RS13555	COG0250	Participates in transcription elongation, termination and antitermination
LK07_RS13570	COG0436	Aminotransferase
LK07_RS13575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK07_RS13585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LK07_RS13605	COG2030	dehydratase
LK07_RS13610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LK07_RS13630	COG0702	epimerase
LK07_RS13675	COG2318	DinB family
LK07_RS13690	COG1666	GTP binding
LK07_RS13695	COG4974	Belongs to the 'phage' integrase family
LK07_RS13705	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS13710	COG2261	transglycosylase associated protein
LK07_RS13720	COG3304	Inner membrane component domain
LK07_RS13725	COG0501	Belongs to the peptidase M48B family
LK07_RS13730	COG1007	ATP synthesis coupled electron transport
LK07_RS13735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS13745	COG0713	ATP synthesis coupled electron transport
LK07_RS13750	COG0839	Belongs to the complex I subunit 6 family
LK07_RS13755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS13760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LK07_RS13765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS13770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS13775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS13795	COG0674	pyruvate-flavodoxin oxidoreductase activity
LK07_RS13795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LK07_RS13800	COG1013	pyruvate-flavodoxin oxidoreductase activity
LK07_RS13805	COG1733	regulation of RNA biosynthetic process
LK07_RS13810	COG0702	epimerase
LK07_RS13830	COG1131	(ABC) transporter
LK07_RS13840	COG0142	geranyltranstransferase activity
LK07_RS13845	COG3953	SLT domain
LK07_RS13845	COG5280	Phage tail tape measure protein TP901
LK07_RS13850	COG0561	phosphatase activity
LK07_RS13870	COG1131	(ABC) transporter
LK07_RS13880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LK07_RS13885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS13920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK07_RS13925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK07_RS13940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK07_RS13955	COG2814	Major facilitator Superfamily
LK07_RS13970	COG3629	intracellular signal transduction
LK07_RS13970	COG3903	Transcriptional regulator
LK07_RS13980	COG0514	ATP-dependent DNA helicase (RecQ)
LK07_RS13985	COG1007	ATP synthesis coupled electron transport
LK07_RS13995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LK07_RS14000	COG0713	ATP synthesis coupled electron transport
LK07_RS14005	COG0839	Belongs to the complex I subunit 6 family
LK07_RS14010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS14015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LK07_RS14020	COG1034	ATP synthesis coupled electron transport
LK07_RS14025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LK07_RS14035	COG0649	NAD binding
LK07_RS14040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS14045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK07_RS14075	COG2226	methyltransferase
LK07_RS14085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LK07_RS14105	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LK07_RS14110	COG1278	Cold shock
LK07_RS14145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LK07_RS14155	COG0163	prenyltransferase activity
LK07_RS14160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LK07_RS14165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LK07_RS14190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK07_RS14195	COG1333	cytochrome c biogenesis protein
LK07_RS14205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK07_RS14215	COG0406	alpha-ribazole phosphatase activity
LK07_RS14220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK07_RS14235	COG0582	viral genome integration into host DNA
LK07_RS14275	COG0242	peptide deformylase activity
LK07_RS14280	COG2045	Belongs to the ComB family
LK07_RS14305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LK07_RS14320	COG0640	Transcriptional regulator
LK07_RS14325	COG2072	flavoprotein involved in K transport
LK07_RS14330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK07_RS14340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK07_RS14360	COG0697	spore germination
LK07_RS14380	COG2362	D-Aminopeptidase
LK07_RS14390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK07_RS14390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK07_RS14395	COG2205	protein histidine kinase activity
LK07_RS14410	COG1742	UPF0060 membrane protein
LK07_RS14425	COG1690	Belongs to the RtcB family
LK07_RS14445	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LK07_RS14450	COG0018	arginyl-trna synthetase
LK07_RS14455	COG0583	DNA-binding transcription factor activity
LK07_RS14485	COG3152	Membrane
LK07_RS14490	COG0113	porphobilinogen synthase activity
LK07_RS14510	COG1648	precorrin-2 dehydrogenase activity
LK07_RS14510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK07_RS14515	COG0181	hydroxymethylbilane synthase activity
LK07_RS14520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LK07_RS14525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LK07_RS14575	COG0123	including yeast histone deacetylase and acetoin utilization protein
LK07_RS14590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK07_RS14615	COG0180	Tryptophanyl-tRNA synthetase
LK07_RS14620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LK07_RS14630	COG1129	ABC transporter
LK07_RS14630	COG0842	Transport permease protein
LK07_RS14645	COG4991	sh3 domain protein
LK07_RS14650	COG0515	serine threonine protein kinase
LK07_RS14650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK07_RS14655	COG0129	dihydroxy-acid dehydratase activity
LK07_RS14660	COG1309	transcriptional regulator
LK07_RS14665	COG1082	Xylose isomerase domain protein TIM barrel
LK07_RS14670	COG0248	Ppx GppA phosphatase
LK07_RS14690	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LK07_RS14700	COG1194	a g-specific adenine glycosylase
LK07_RS14705	COG1595	DNA-templated transcription, initiation
LK07_RS14715	COG0745	RESPONSE REGULATOR receiver
LK07_RS14720	COG2205	protein histidine kinase activity
LK07_RS14735	COG0739	heme binding
LK07_RS14765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LK07_RS14785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LK07_RS14795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LK07_RS14800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LK07_RS14810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LK07_RS14815	COG2197	response regulator
LK07_RS14835	COG0649	NAD binding
LK07_RS14860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK07_RS14860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK07_RS14875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LK07_RS14890	COG0302	gtp cyclohydrolase
LK07_RS14905	COG0037	tRNA processing
LK07_RS14915	COG2027	D-alanyl-D-alanine carboxypeptidase
LK07_RS14920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LK07_RS14935	COG0393	Putative heavy-metal-binding
LK07_RS14940	COG0789	Transcriptional regulator
LK07_RS14945	COG0076	glutamate decarboxylase activity
LK07_RS14950	COG2318	DinB family
LK07_RS14960	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS15000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK07_RS15000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK07_RS15005	COG3903	Transcriptional regulator
LK07_RS15005	COG3629	intracellular signal transduction
LK07_RS15015	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LK07_RS15025	COG2205	protein histidine kinase activity
LK07_RS15030	COG0745	RESPONSE REGULATOR receiver
LK07_RS15040	COG0577	efflux transmembrane transporter activity
LK07_RS15040	COG1136	(ABC) transporter
LK07_RS15045	COG1136	(ABC) transporter
LK07_RS15045	COG0577	efflux transmembrane transporter activity
LK07_RS15080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LK07_RS15085	COG1754	DNA topoisomerase type I activity
LK07_RS15085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LK07_RS15095	COG2890	protein-(glutamine-N5) methyltransferase activity
LK07_RS15105	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LK07_RS15115	COG1366	Belongs to the anti-sigma-factor antagonist family
LK07_RS15120	COG1111	helicase
LK07_RS15120	COG1205	dead DEAH box helicase
LK07_RS15180	COG0659	secondary active sulfate transmembrane transporter activity
LK07_RS15185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK07_RS15200	COG2267	carboxylic ester hydrolase activity
LK07_RS15235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK07_RS15260	COG0003	Pfam Anion-transporting ATPase
LK07_RS15285	COG1408	metallophosphoesterase
LK07_RS15320	COG3209	COG3209 Rhs family protein
LK07_RS15320	COG4104	PAAR repeat-containing protein
LK07_RS15330	COG1609	Transcriptional regulator
LK07_RS15405	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS15430	COG2095	MarC family integral membrane protein
LK07_RS15440	COG0745	RESPONSE REGULATOR receiver
LK07_RS15445	COG2205	protein histidine kinase activity
LK07_RS15455	COG1477	protein flavinylation
LK07_RS15465	COG4656	Part of a membrane complex involved in electron transport
LK07_RS15490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK07_RS15490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK07_RS15505	COG1937	Protein conserved in bacteria
LK07_RS15510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK07_RS15515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK07_RS15530	COG0477	Major facilitator Superfamily
LK07_RS15550	COG0701	Predicted permease
LK07_RS15570	COG1595	DNA-templated transcription, initiation
LK07_RS15590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LK07_RS15595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LK07_RS15605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK07_RS15605	COG0515	serine threonine protein kinase
LK07_RS15610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK07_RS15615	COG1802	Transcriptional regulator
LK07_RS15630	COG0737	Belongs to the 5'-nucleotidase family
LK07_RS15635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LK07_RS15650	COG1131	(ABC) transporter
LK07_RS15655	COG3559	Exporter of polyketide antibiotics
LK07_RS15685	COG3844	kynureninase activity
LK07_RS15690	COG3483	tryptophan 2,3-dioxygenase activity
LK07_RS15700	COG0191	fructose-bisphosphate aldolase activity
LK07_RS15705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LK07_RS15720	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LK07_RS15800	COG0542	response to heat
LK07_RS15825	COG4213	ABC transporter substrate-binding protein
LK07_RS15835	COG0789	Transcriptional regulator
LK07_RS15840	COG0484	heat shock protein binding
LK07_RS15845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LK07_RS15850	COG0443	Heat shock 70 kDa protein
LK07_RS15855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK07_RS15860	COG0247	lactate metabolic process
LK07_RS15860	COG2181	nitrate reductase activity
LK07_RS15880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LK07_RS15885	COG0717	Belongs to the dCTP deaminase family
LK07_RS15945	COG4566	intracellular signal transduction
LK07_RS15950	COG1592	Rubrerythrin
LK07_RS15955	COG1309	transcriptional regulator
LK07_RS15960	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS15970	COG1278	Cold shock
LK07_RS15975	COG0513	Belongs to the DEAD box helicase family
LK07_RS15985	COG2205	protein histidine kinase activity
LK07_RS15990	COG0745	RESPONSE REGULATOR receiver
LK07_RS16000	COG2124	cytochrome p450
LK07_RS16030	COG1252	NADH dehydrogenase
LK07_RS16035	COG1595	DNA-templated transcription, initiation
LK07_RS16050	COG2226	methyltransferase
LK07_RS16105	COG3261	NADH dehydrogenase
LK07_RS16105	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LK07_RS16110	COG0651	ATP synthesis coupled electron transport
LK07_RS16120	COG0650	Formate hydrogenlyase subunit 4
LK07_RS16130	COG3260	NADH ubiquinone oxidoreductase 20
LK07_RS16140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK07_RS16180	COG1309	transcriptional regulator
LK07_RS16185	COG0842	Transport permease protein
LK07_RS16185	COG1129	ABC transporter
LK07_RS16205	COG1595	DNA-templated transcription, initiation
LK07_RS16225	COG2208	phosphoserine phosphatase activity
LK07_RS16255	COG2255	four-way junction helicase activity
LK07_RS16275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK07_RS16295	COG0366	Alpha amylase catalytic
LK07_RS16305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LK07_RS16355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK07_RS16370	COG1289	transmembrane transporter activity
LK07_RS16380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK07_RS16390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LK07_RS16405	COG1741	Belongs to the pirin family
LK07_RS16415	COG1960	acyl-CoA dehydrogenase activity
LK07_RS16420	COG1362	aminopeptidase activity
LK07_RS16445	COG2814	Major facilitator Superfamily
LK07_RS16465	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK07_RS16470	COG0022	dehydrogenase e1 component
LK07_RS16490	COG0515	serine threonine protein kinase
LK07_RS16495	COG0515	serine threonine protein kinase
LK07_RS16510	COG0604	alcohol dehydrogenase
LK07_RS16510	COG3321	synthase
LK07_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS16515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK07_RS16545	COG1522	sequence-specific DNA binding
LK07_RS16550	COG1309	transcriptional regulator
LK07_RS16555	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK07_RS16580	COG3396	Phenylacetate-CoA oxygenase
LK07_RS16585	COG3460	Phenylacetate-CoA oxygenase
LK07_RS16590	COG3396	Phenylacetate-CoA oxygenase
LK07_RS16595	COG2151	metal-sulfur cluster biosynthetic enzyme
LK07_RS16600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK07_RS16650	COG1716	ATPase activity
LK07_RS16655	COG1716	ATPase activity
LK07_RS16670	COG0768	penicillin binding
LK07_RS16680	COG0515	serine threonine protein kinase
LK07_RS16685	COG3764	Sortase (surface protein transpeptidase)
LK07_RS16690	COG3764	Sortase (surface protein transpeptidase)
LK07_RS16705	COG3764	Sortase (surface protein transpeptidase)
LK07_RS16720	COG0705	Rhomboid family
LK07_RS16780	COG0515	serine threonine protein kinase
LK07_RS16820	COG4249	Peptidase C14 caspase catalytic subunit p20
LK07_RS16820	COG2319	Wd-40 repeat
LK07_RS16840	COG2188	Transcriptional regulator
LK07_RS16905	COG0582	viral genome integration into host DNA
LK07_RS16920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK07_RS16925	COG0187	DNA topoisomerase II activity
LK07_RS16930	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LK07_RS16935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LK07_RS16940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LK07_RS16945	COG0592	DNA-directed DNA polymerase activity
LK07_RS16955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK07_RS16960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LK07_RS16965	COG0594	ribonuclease P activity
LK07_RS16970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LK07_RS16975	COG0706	membrane insertase activity
LK07_RS16985	COG0357	Ribosomal RNA small subunit methyltransferase G
LK07_RS16990	COG1192	Involved in chromosome partitioning
LK07_RS17005	COG3118	belongs to the thioredoxin family
LK07_RS17010	COG0492	ferredoxin-NADP+ reductase activity
LK07_RS17020	COG1595	DNA-templated transcription, initiation
LK07_RS17025	COG0515	serine threonine protein kinase
LK07_RS17025	COG2815	serine threonine protein kinase
LK07_RS17040	COG0617	tRNA 3'-terminal CCA addition
LK07_RS17060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK07_RS17085	COG0360	Binds together with S18 to 16S ribosomal RNA
LK07_RS17090	COG0629	single-stranded DNA binding
LK07_RS17095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LK07_RS17100	COG0359	binds to the 23S rRNA
LK07_RS17110	COG0305	Participates in initiation and elongation during chromosome replication
LK07_RS17160	COG0626	cystathionine gamma-synthase activity
LK07_RS17165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK07_RS17170	COG1950	PFAM Membrane protein of
LK07_RS17175	COG0662	Cupin 2, conserved barrel domain protein
LK07_RS17200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LK07_RS17215	COG1609	Transcriptional regulator
LK07_RS17220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK07_RS17230	COG1271	oxidase subunit
LK07_RS17235	COG1294	oxidase, subunit
LK07_RS17240	COG4988	ABC transporter
LK07_RS17245	COG0561	phosphatase activity
LK07_RS17260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK07_RS17280	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LK07_RS17295	COG1131	(ABC) transporter
LK07_RS17305	COG1131	(ABC) transporter
LK07_RS17325	COG0561	phosphatase activity
LK07_RS17330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LK07_RS17385	COG0006	proline dipeptidase activity
LK07_RS17425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK07_RS17575	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS17580	COG1595	DNA-templated transcription, initiation
LK07_RS17585	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS17590	COG2814	Major facilitator Superfamily
LK07_RS17595	COG1309	transcriptional regulator
LK07_RS17600	COG0784	Response regulator, receiver
LK07_RS17680	COG3629	intracellular signal transduction
LK07_RS17680	COG3903	Transcriptional regulator
LK07_RS17705	COG0745	RESPONSE REGULATOR receiver
LK07_RS17710	COG2205	protein histidine kinase activity
LK07_RS17720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LK07_RS17725	COG0477	Major facilitator Superfamily
LK07_RS17760	COG1191	sigma factor activity
LK07_RS17765	COG1191	sigma factor activity
LK07_RS17800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LK07_RS17925	COG2801	Transposase and inactivated derivatives
LK07_RS17925	COG3415	Transposase
LK07_RS18045	COG0151	Belongs to the GarS family
LK07_RS18060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LK07_RS18070	COG2197	response regulator
LK07_RS18105	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK07_RS18110	COG0047	phosphoribosylformylglycinamidine synthase activity
LK07_RS18115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK07_RS18135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LK07_RS18145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LK07_RS18170	COG1643	Atp-dependent helicase
LK07_RS18205	COG0513	Belongs to the DEAD box helicase family
LK07_RS18295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LK07_RS18345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK07_RS18355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK07_RS18355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK07_RS18375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LK07_RS18380	COG0579	oxidoreductase
LK07_RS18405	COG1252	NADH dehydrogenase
LK07_RS18525	COG0697	spore germination
LK07_RS18530	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS18535	COG1982	Orn Lys Arg decarboxylase major
LK07_RS18555	COG0583	DNA-binding transcription factor activity
LK07_RS18565	COG1309	transcriptional regulator
LK07_RS18570	COG0791	NLP P60 protein
LK07_RS18575	COG0671	phosphoesterase, PA-phosphatase related
LK07_RS18580	COG0277	FAD linked oxidase domain protein
LK07_RS18585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LK07_RS18600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK07_RS18610	COG0306	phosphate transporter
LK07_RS18620	COG1937	Protein conserved in bacteria
LK07_RS18630	COG0494	nUDIX hydrolase
LK07_RS18630	COG0406	alpha-ribazole phosphatase activity
LK07_RS18640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LK07_RS18645	COG0456	acetyltransferase
LK07_RS18655	COG0745	RESPONSE REGULATOR receiver
LK07_RS18665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK07_RS18670	COG1609	Transcriptional regulator
LK07_RS18675	COG0745	RESPONSE REGULATOR receiver
LK07_RS18710	COG2897	thiosulfate sulfurtransferase activity
LK07_RS18725	COG0156	8-amino-7-oxononanoate synthase activity
LK07_RS18755	COG3485	protocatechuate 3,4-dioxygenase
LK07_RS18760	COG0735	belongs to the Fur family
LK07_RS18765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK07_RS18770	COG1490	D-aminoacyl-tRNA deacylase activity
LK07_RS18780	COG4552	Acetyltransferase involved in intracellular survival and related
LK07_RS18785	COG2188	Transcriptional regulator
LK07_RS18795	COG0546	phosphoglycolate phosphatase activity
LK07_RS18805	COG1309	transcriptional regulator
LK07_RS18810	COG3973	AAA domain
LK07_RS18820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK07_RS18885	COG0438	transferase activity, transferring glycosyl groups
LK07_RS18895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK07_RS18905	COG0588	phosphoglycerate mutase activity
LK07_RS18930	COG5002	protein histidine kinase activity
LK07_RS18950	COG1329	Transcriptional regulator
LK07_RS18960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LK07_RS18965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LK07_RS18975	COG0215	cysteine-tRNA ligase activity
LK07_RS18980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK07_RS19000	COG3842	ATPase activity
LK07_RS19010	COG0582	viral genome integration into host DNA
LK07_RS19060	COG2188	Transcriptional regulator
LK07_RS19120	COG4974	Belongs to the 'phage' integrase family
LK07_RS19200	COG0592	DNA-directed DNA polymerase activity
LK07_RS19215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK07_RS19220	COG0726	polysaccharide deacetylase
LK07_RS19230	COG1131	(ABC) transporter
LK07_RS19240	COG4585	Histidine kinase
LK07_RS19245	COG2197	response regulator
LK07_RS19260	COG0456	acetyltransferase
LK07_RS19305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LK07_RS19320	COG3300	MHYT domain
LK07_RS19320	COG5001	Diguanylate cyclase
LK07_RS19370	COG0463	Glycosyl transferase, family 2
LK07_RS19385	COG1278	Cold shock
LK07_RS19390	COG0459	protein refolding
LK07_RS19435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK07_RS19435	COG1263	PTS System
LK07_RS19440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LK07_RS19445	COG1737	Transcriptional regulator
LK07_RS19470	COG3773	Cell wall hydrolase
LK07_RS19470	COG3409	Peptidoglycan-binding domain 1 protein
LK07_RS19485	COG3409	Peptidoglycan-binding domain 1 protein
LK07_RS19505	COG3973	AAA domain
LK07_RS19525	COG1061	Type III restriction enzyme res subunit
LK07_RS19550	COG1278	Cold shock
LK07_RS19555	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LK07_RS19560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LK07_RS19570	COG2814	Major facilitator Superfamily
LK07_RS19635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK07_RS19645	COG2252	PERMEase
LK07_RS19675	COG0667	Aldo Keto reductase
LK07_RS19695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LK07_RS19700	COG0247	lactate metabolic process
LK07_RS19700	COG0277	FAD linked oxidase domain protein
LK07_RS19710	COG1132	(ABC) transporter
LK07_RS19715	COG5006	permease, DMT superfamily
LK07_RS19745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK07_RS19760	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS19770	COG1309	transcriptional regulator
LK07_RS19785	COG0259	pyridoxamine-phosphate oxidase activity
LK07_RS19800	COG4821	SIS domain
LK07_RS19865	COG1366	Belongs to the anti-sigma-factor antagonist family
LK07_RS19870	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS19880	COG1960	acyl-CoA dehydrogenase activity
LK07_RS19885	COG1960	acyl-CoA dehydrogenase activity
LK07_RS19905	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS19910	COG1960	acyl-CoA dehydrogenase activity
LK07_RS19940	COG1024	Enoyl-CoA hydratase
LK07_RS19950	COG2072	flavoprotein involved in K transport
LK07_RS19980	COG1960	acyl-CoA dehydrogenase activity
LK07_RS20005	COG1280	lysine exporter protein (LysE YggA)
LK07_RS20010	COG1522	sequence-specific DNA binding
LK07_RS20015	COG1309	transcriptional regulator
LK07_RS20025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK07_RS20025	COG0515	serine threonine protein kinase
LK07_RS20030	COG1024	Enoyl-CoA hydratase
LK07_RS20050	COG3629	intracellular signal transduction
LK07_RS20050	COG3903	Transcriptional regulator
LK07_RS20075	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LK07_RS20080	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS20100	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LK07_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS20160	COG0386	Belongs to the glutathione peroxidase family
LK07_RS20180	COG2205	protein histidine kinase activity
LK07_RS20185	COG0745	RESPONSE REGULATOR receiver
LK07_RS20215	COG2815	serine threonine protein kinase
LK07_RS20215	COG0515	serine threonine protein kinase
LK07_RS20220	COG0412	Dienelactone hydrolase
LK07_RS20225	COG2815	serine threonine protein kinase
LK07_RS20225	COG0515	serine threonine protein kinase
LK07_RS20230	COG0577	efflux transmembrane transporter activity
LK07_RS20230	COG1136	(ABC) transporter
LK07_RS20235	COG1136	(ABC) transporter
LK07_RS20245	COG0745	RESPONSE REGULATOR receiver
LK07_RS20250	COG5002	protein histidine kinase activity
LK07_RS20320	COG1942	4-Oxalocrotonate Tautomerase
LK07_RS20330	COG2814	Major facilitator Superfamily
LK07_RS20335	COG0583	DNA-binding transcription factor activity
LK07_RS20365	COG3384	dioxygenase
LK07_RS20390	COG0477	Major facilitator Superfamily
LK07_RS20405	COG3191	aminopeptidase activity
LK07_RS20420	COG1970	mechanosensitive ion channel activity
LK07_RS20430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LK07_RS20455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LK07_RS20460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK07_RS20470	COG0315	cyclic pyranopterin monophosphate synthase activity
LK07_RS20475	COG0521	Mo-molybdopterin cofactor biosynthetic process
LK07_RS20475	COG0315	cyclic pyranopterin monophosphate synthase activity
LK07_RS20510	COG0582	viral genome integration into host DNA
LK07_RS20580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LK07_RS20665	COG0148	phosphopyruvate hydratase activity
LK07_RS20670	COG0454	-acetyltransferase
LK07_RS20685	COG2072	flavoprotein involved in K transport
LK07_RS20690	COG2267	carboxylic ester hydrolase activity
LK07_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS20705	COG4946	Tricorn protease homolog
LK07_RS20705	COG0793	Belongs to the peptidase S41A family
LK07_RS20715	COG2409	Drug exporters of the RND superfamily
LK07_RS20735	COG1764	response to oxidative stress
LK07_RS20740	COG1846	Transcriptional regulator
LK07_RS20745	COG1122	ATPase activity
LK07_RS20755	COG0310	cobalt ion transport
LK07_RS20765	COG0768	penicillin binding
LK07_RS20790	COG0084	hydrolase, TatD family'
LK07_RS20800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK07_RS20805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LK07_RS20810	COG0488	(ABC) transporter
LK07_RS20845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LK07_RS20865	COG2197	response regulator
LK07_RS20875	COG4106	trans-aconitate 2-methyltransferase activity
LK07_RS20885	COG1309	transcriptional regulator
LK07_RS20895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LK07_RS20905	COG0193	aminoacyl-tRNA hydrolase activity
LK07_RS20910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LK07_RS20915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LK07_RS20920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LK07_RS20935	COG4585	Histidine kinase
LK07_RS21020	COG1652	LysM domain
LK07_RS21030	COG0148	phosphopyruvate hydratase activity
LK07_RS21065	COG1252	NADH dehydrogenase
LK07_RS21070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LK07_RS21075	COG0577	efflux transmembrane transporter activity
LK07_RS21080	COG1136	(ABC) transporter
LK07_RS21080	COG0577	efflux transmembrane transporter activity
LK07_RS21110	COG0183	Belongs to the thiolase family
LK07_RS21115	COG2755	lipolytic protein G-D-S-L family
LK07_RS21125	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS21130	COG0736	holo-[acyl-carrier-protein] synthase activity
LK07_RS21140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK07_RS21150	COG0802	atpase or kinase
LK07_RS21170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LK07_RS21190	COG0726	polysaccharide deacetylase
LK07_RS21195	COG0726	polysaccharide deacetylase
LK07_RS21205	COG0459	protein refolding
LK07_RS21215	COG4221	oxidoreductase activity
LK07_RS21225	COG0583	DNA-binding transcription factor activity
LK07_RS21235	COG2197	response regulator
LK07_RS21240	COG1595	DNA-templated transcription, initiation
LK07_RS21250	COG0516	GMP reductase activity
LK07_RS21265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LK07_RS21275	COG2815	serine threonine protein kinase
LK07_RS21275	COG0515	serine threonine protein kinase
LK07_RS21280	COG0515	serine threonine protein kinase
LK07_RS21285	COG2815	serine threonine protein kinase
LK07_RS21285	COG0515	serine threonine protein kinase
LK07_RS21290	COG0515	serine threonine protein kinase
LK07_RS21295	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS21310	COG0519	Catalyzes the synthesis of GMP from XMP
LK07_RS21310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LK07_RS21350	COG2197	response regulator
LK07_RS21375	COG0739	heme binding
LK07_RS21385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS21385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS21400	COG0714	Associated with various cellular activities
LK07_RS21410	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LK07_RS21415	COG0045	succinate-CoA ligase (ADP-forming) activity
LK07_RS21445	COG0138	bifunctional purine biosynthesis protein purh
LK07_RS21465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LK07_RS21480	COG0039	L-malate dehydrogenase activity
LK07_RS21485	COG0477	Major facilitator Superfamily
LK07_RS21495	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS21505	COG0517	IMP dehydrogenase activity
LK07_RS21505	COG4175	Glycine betaine
LK07_RS21510	COG4176	ABC-type proline glycine betaine transport system permease component
LK07_RS21525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK07_RS21535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK07_RS21565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK07_RS21570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK07_RS21575	COG0180	Tryptophanyl-tRNA synthetase
LK07_RS21590	COG1295	ribonuclease BN
LK07_RS21595	COG1686	Belongs to the peptidase S11 family
LK07_RS21610	COG1309	transcriptional regulator
LK07_RS21625	COG1053	succinate dehydrogenase
LK07_RS21635	COG2009	succinate dehydrogenase
LK07_RS21645	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LK07_RS21680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS21680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS21695	COG1216	Glycosyl transferase, family 2
LK07_RS21710	COG2089	acid synthase
LK07_RS21730	COG2205	protein histidine kinase activity
LK07_RS21735	COG0745	RESPONSE REGULATOR receiver
LK07_RS21750	COG1376	ErfK ybiS ycfS ynhG family protein
LK07_RS21760	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LK07_RS21760	COG1473	amidohydrolase
LK07_RS21765	COG1744	ABC transporter substrate-binding protein PnrA-like
LK07_RS21770	COG3845	ABC transporter
LK07_RS21775	COG4603	Belongs to the binding-protein-dependent transport system permease family
LK07_RS21780	COG1079	Belongs to the binding-protein-dependent transport system permease family
LK07_RS21810	COG2814	Major facilitator Superfamily
LK07_RS21815	COG0583	DNA-binding transcription factor activity
LK07_RS21825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK07_RS21850	COG2205	protein histidine kinase activity
LK07_RS21855	COG0745	RESPONSE REGULATOR receiver
LK07_RS21860	COG1595	DNA-templated transcription, initiation
LK07_RS21875	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS21880	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS21885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LK07_RS21895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK07_RS21920	COG4770	biotin carboxylase activity
LK07_RS21930	COG0424	maF-like protein
LK07_RS21945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK07_RS21955	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LK07_RS21965	COG1024	Enoyl-CoA hydratase
LK07_RS21975	COG2986	histidine ammonia-lyase
LK07_RS22005	COG1136	(ABC) transporter
LK07_RS22020	COG1064	alcohol dehydrogenase
LK07_RS22030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK07_RS22035	COG0477	Major facilitator Superfamily
LK07_RS22060	COG2255	four-way junction helicase activity
LK07_RS22065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LK07_RS22080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LK07_RS22090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LK07_RS22100	COG1331	Highly conserved protein containing a thioredoxin domain
LK07_RS22115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK07_RS22135	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS22135	COG0300	oxidoreductase activity
LK07_RS22135	COG3321	synthase
LK07_RS22135	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS22135	COG3321	synthase
LK07_RS22135	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS22135	COG0300	oxidoreductase activity
LK07_RS22135	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS22135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS22135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS22140	COG3251	PFAM MbtH domain protein
LK07_RS22175	COG2175	clavaminate synthase activity
LK07_RS22180	COG2197	response regulator
LK07_RS22185	COG1136	(ABC) transporter
LK07_RS22185	COG0577	efflux transmembrane transporter activity
LK07_RS22195	COG4585	Histidine kinase
LK07_RS22225	COG0154	amidase activity
LK07_RS22240	COG1331	Highly conserved protein containing a thioredoxin domain
LK07_RS22255	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LK07_RS22265	COG0436	Aminotransferase
LK07_RS22285	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LK07_RS22305	COG0251	oxidation-reduction process
LK07_RS22345	COG2894	cell division
LK07_RS22380	COG2197	response regulator
LK07_RS22405	COG1309	transcriptional regulator
LK07_RS22415	COG1073	alpha beta
LK07_RS22415	COG2226	methyltransferase
LK07_RS22420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK07_RS22430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LK07_RS22435	COG0741	lytic transglycosylase activity
LK07_RS22450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK07_RS22455	COG0450	alkyl hydroperoxide reductase
LK07_RS22485	COG1136	(ABC) transporter
LK07_RS22505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK07_RS22520	COG0114	fumarate hydratase activity
LK07_RS22555	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LK07_RS22555	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LK07_RS22580	COG0778	Nitroreductase
LK07_RS22585	COG1722	exodeoxyribonuclease VII activity
LK07_RS22590	COG1570	exodeoxyribonuclease VII activity
LK07_RS22595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LK07_RS22610	COG0012	GTP binding
LK07_RS22880	COG1053	succinate dehydrogenase
LK07_RS22900	COG1217	gtp-binding protein TYPA
LK07_RS22905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK07_RS22910	COG4166	transmembrane transport
LK07_RS22915	COG0601	transmembrane transport
LK07_RS22920	COG0444	Belongs to the ABC transporter superfamily
LK07_RS22930	COG4608	Belongs to the ABC transporter superfamily
LK07_RS22945	COG4608	Belongs to the ABC transporter superfamily
LK07_RS22950	COG0444	Belongs to the ABC transporter superfamily
LK07_RS22955	COG0601	transmembrane transport
LK07_RS22965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK07_RS22975	COG0601	transmembrane transport
LK07_RS22980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK07_RS22985	COG0444	Belongs to the ABC transporter superfamily
LK07_RS22990	COG4608	Belongs to the ABC transporter superfamily
LK07_RS23005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LK07_RS23020	COG1131	(ABC) transporter
LK07_RS23030	COG4585	Histidine kinase
LK07_RS23035	COG2197	response regulator
LK07_RS23070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK07_RS23075	COG1611	Belongs to the LOG family
LK07_RS23080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LK07_RS23090	COG0519	Catalyzes the synthesis of GMP from XMP
LK07_RS23095	COG1024	Enoyl-CoA hydratase
LK07_RS23110	COG1595	DNA-templated transcription, initiation
LK07_RS23125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK07_RS23160	COG0598	Magnesium transport protein CorA
LK07_RS23175	COG0613	PHP domain protein
LK07_RS23180	COG2095	MarC family integral membrane protein
LK07_RS23190	COG1432	Conserved Protein
LK07_RS23290	COG0210	DNA helicase
LK07_RS23295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK07_RS23300	COG2816	NAD+ diphosphatase activity
LK07_RS23335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LK07_RS23385	COG3480	Lon protease (S16) C-terminal proteolytic domain
LK07_RS23395	COG1615	UPF0182 protein
LK07_RS23425	COG0483	inositol monophosphate 1-phosphatase activity
LK07_RS23435	COG2076	Multidrug Resistance protein
LK07_RS23445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LK07_RS23455	COG2135	peptidase activity
LK07_RS23465	COG1595	DNA-templated transcription, initiation
LK07_RS23470	COG5662	AntiSigma factor
LK07_RS23475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LK07_RS23475	COG2199	diguanylate cyclase activity
LK07_RS23490	COG0242	peptide deformylase activity
LK07_RS23500	COG2124	cytochrome p450
LK07_RS23505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK07_RS23530	COG2188	Transcriptional regulator
LK07_RS23535	COG0363	glucosamine-6-phosphate deaminase activity
LK07_RS23550	COG1597	lipid kinase activity
LK07_RS23565	COG2172	sigma factor antagonist activity
LK07_RS23580	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LK07_RS23585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LK07_RS23590	COG0142	geranyltranstransferase activity
LK07_RS23640	COG1126	abc transporter atp-binding protein
LK07_RS23645	COG0765	amino acid transport
LK07_RS23660	COG0281	malic enzyme
LK07_RS23665	COG0604	alcohol dehydrogenase
LK07_RS23710	COG2255	four-way junction helicase activity
LK07_RS23735	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK07_RS23735	COG0567	Dehydrogenase, E1 component
LK07_RS23740	COG2205	protein histidine kinase activity
LK07_RS23745	COG0745	RESPONSE REGULATOR receiver
LK07_RS23760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK07_RS23850	COG2205	protein histidine kinase activity
LK07_RS23870	COG3285	dna ligase
LK07_RS23870	COG1793	dna ligase
LK07_RS23875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LK07_RS23885	COG0640	Transcriptional regulator
LK07_RS23890	COG0671	phosphoesterase, PA-phosphatase related
LK07_RS23895	COG0586	Pfam SNARE associated Golgi protein
LK07_RS23930	COG2217	Heavy metal translocating P-type atpase
LK07_RS23960	COG0516	GMP reductase activity
LK07_RS23960	COG0517	IMP dehydrogenase activity
LK07_RS24140	COG3883	PFAM NLP P60 protein
LK07_RS24140	COG0791	NLP P60 protein
LK07_RS24170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK07_RS24230	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LK07_RS24250	COG3547	Transposase (IS116 IS110 IS902 family)
LK07_RS24275	COG0745	RESPONSE REGULATOR receiver
LK07_RS24280	COG0018	arginyl-trna synthetase
LK07_RS24280	COG0018	arginyl-trna synthetase
LK07_RS24285	COG0019	diaminopimelate decarboxylase activity
LK07_RS24290	COG0460	homoserine dehydrogenase
LK07_RS24295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LK07_RS24300	COG0083	homoserine kinase activity
LK07_RS24310	COG1316	TRANSCRIPTIONal
LK07_RS24315	COG0254	rRNA binding
LK07_RS24320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LK07_RS24325	COG2890	protein-(glutamine-N5) methyltransferase activity
LK07_RS24335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK07_RS24340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK07_RS24345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK07_RS24360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK07_RS24365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LK07_RS24370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK07_RS24375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LK07_RS24380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LK07_RS24385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LK07_RS24390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LK07_RS24445	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK07_RS24460	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LK07_RS24495	COG1131	(ABC) transporter
LK07_RS24515	COG0183	Belongs to the thiolase family
LK07_RS24585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS24585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS24625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LK07_RS24630	COG0280	phosphate acetyltransferase
LK07_RS24630	COG0857	belongs to the CobB CobQ family
LK07_RS24635	COG0205	6-phosphofructokinase activity
LK07_RS24650	COG4565	transcriptional regulatory protein
LK07_RS24655	COG3290	protein histidine kinase activity
LK07_RS24660	COG1301	dicarboxylic acid transport
LK07_RS24670	COG0477	Major facilitator Superfamily
LK07_RS24690	COG3118	belongs to the thioredoxin family
LK07_RS24700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK07_RS24705	COG3281	Trehalose synthase
LK07_RS24715	COG0366	Alpha amylase catalytic
LK07_RS24720	COG0058	SHG alpha-glucan phosphorylase activity
LK07_RS24735	COG1132	(ABC) transporter
LK07_RS24740	COG1132	(ABC) transporter
LK07_RS24770	COG1376	ErfK ybiS ycfS ynhG family protein
LK07_RS24775	COG1376	ErfK ybiS ycfS ynhG family protein
LK07_RS24810	COG1388	LysM domain
LK07_RS24810	COG3942	CHAP domain
LK07_RS24815	COG1760	l-serine dehydratase
LK07_RS24820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK07_RS24825	COG0509	glycine decarboxylation via glycine cleavage system
LK07_RS24830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK07_RS24850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK07_RS24865	COG0444	Belongs to the ABC transporter superfamily
LK07_RS24870	COG4608	Belongs to the ABC transporter superfamily
LK07_RS24875	COG2860	membrane
LK07_RS24895	COG2378	regulation of single-species biofilm formation
LK07_RS24925	COG0482	sulfurtransferase activity
LK07_RS24940	COG1611	Belongs to the LOG family
LK07_RS24945	COG4221	oxidoreductase activity
LK07_RS24955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK07_RS24965	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK07_RS24970	COG0154	amidase activity
LK07_RS24980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK07_RS24990	COG2409	Drug exporters of the RND superfamily
LK07_RS24995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK07_RS25005	COG2197	response regulator
LK07_RS25015	COG2133	pyrroloquinoline quinone binding
LK07_RS25020	COG0667	Aldo Keto reductase
LK07_RS25030	COG5001	Diguanylate cyclase
LK07_RS25040	COG0440	acetolactate synthase activity
LK07_RS25045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LK07_RS25055	COG0477	Major facilitator Superfamily
LK07_RS25085	COG0506	proline dehydrogenase activity
LK07_RS25090	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS25100	COG0473	3-isopropylmalate dehydrogenase activity
LK07_RS25105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK07_RS25115	COG0832	Belongs to the urease beta subunit family
LK07_RS25115	COG0831	urea catabolic process
LK07_RS25120	COG0804	urea catabolic process
LK07_RS25125	COG2957	Belongs to the agmatine deiminase family
LK07_RS25140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK07_RS25150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK07_RS25170	COG2018	Roadblock/LC7 domain
LK07_RS25190	COG2018	Roadblock/LC7 domain
LK07_RS25195	COG5002	protein histidine kinase activity
LK07_RS25205	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK07_RS25210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK07_RS25255	COG1414	Transcriptional regulator
LK07_RS25260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LK07_RS25265	COG0066	3-isopropylmalate dehydratase activity
LK07_RS25275	COG0776	regulation of translation
LK07_RS25285	COG1920	GTP binding
LK07_RS25295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK07_RS25300	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK07_RS25320	COG0351	phosphomethylpyrimidine kinase
LK07_RS25325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK07_RS25330	COG1461	Dihydroxyacetone kinase
LK07_RS25340	COG0326	Molecular chaperone. Has ATPase activity
LK07_RS25350	COG0742	ribosomal rna small subunit methyltransferase
LK07_RS25355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LK07_RS25370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LK07_RS25375	COG0571	ribonuclease III activity
LK07_RS25380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK07_RS25385	COG1733	regulation of RNA biosynthetic process
LK07_RS25400	COG2340	Cysteine-rich secretory protein family
LK07_RS25405	COG1254	Belongs to the acylphosphatase family
LK07_RS25430	COG0477	Major facilitator Superfamily
LK07_RS25465	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LK07_RS25475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK07_RS25480	COG4106	trans-aconitate 2-methyltransferase activity
LK07_RS25490	COG0228	four-way junction DNA binding
LK07_RS25495	COG1837	Belongs to the UPF0109 family
LK07_RS25500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LK07_RS25505	COG0336	Belongs to the RNA methyltransferase TrmD family
LK07_RS25510	COG0335	large ribosomal subunit rRNA binding
LK07_RS25520	COG0681	Belongs to the peptidase S26 family
LK07_RS25545	COG0792	nuclease activity
LK07_RS25560	COG1191	sigma factor activity
LK07_RS25575	COG0052	Belongs to the universal ribosomal protein uS2 family
LK07_RS25580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LK07_RS25585	COG0528	UMP kinase activity
LK07_RS25590	COG0233	cytoplasmic translational termination
LK07_RS25595	COG0575	Belongs to the CDS family
LK07_RS25605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LK07_RS25615	COG4208	sulfate ABC transporter
LK07_RS25620	COG3842	ATPase activity
LK07_RS25645	COG1136	(ABC) transporter
LK07_RS25650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK07_RS25660	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS25680	COG0584	glycerophosphoryl diester phosphodiesterase
LK07_RS25685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK07_RS25710	COG3842	ATPase activity
LK07_RS25715	COG1176	ABC-type spermidine putrescine transport system, permease component I
LK07_RS25720	COG1177	transmembrane transport
LK07_RS25725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK07_RS25755	COG2508	Transcriptional regulator
LK07_RS25760	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS25780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LK07_RS25785	COG0750	zinc metalloprotease
LK07_RS25790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK07_RS25805	COG0442	prolyl-tRNA aminoacylation
LK07_RS25830	COG0779	Required for maturation of 30S ribosomal subunits
LK07_RS25845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LK07_RS25855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LK07_RS25860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LK07_RS25875	COG0455	bacterial-type flagellum organization
LK07_RS25895	COG1404	Belongs to the peptidase S8 family
LK07_RS25920	COG1404	Belongs to the peptidase S8 family
LK07_RS25935	COG1674	ftsk spoiiie
LK07_RS25955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LK07_RS25960	COG1185	polyribonucleotide nucleotidyltransferase activity
LK07_RS25965	COG0612	Peptidase, M16
LK07_RS25970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LK07_RS25990	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LK07_RS25995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK07_RS26000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LK07_RS26035	COG2770	Histidine kinase
LK07_RS26035	COG2208	phosphoserine phosphatase activity
LK07_RS26045	COG2205	protein histidine kinase activity
LK07_RS26045	COG0784	Response regulator, receiver
LK07_RS26055	COG1674	ftsk spoiiie
LK07_RS26065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK07_RS26075	COG1546	Belongs to the CinA family
LK07_RS26075	COG1058	Belongs to the CinA family
LK07_RS26080	COG1396	sequence-specific DNA binding
LK07_RS26085	COG0783	Belongs to the Dps family
LK07_RS26100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK07_RS26105	COG1201	RNA secondary structure unwinding
LK07_RS26120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LK07_RS26140	COG0765	amino acid transport
LK07_RS26145	COG0765	amino acid transport
LK07_RS26150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK07_RS26155	COG1126	abc transporter atp-binding protein
LK07_RS26160	COG0745	RESPONSE REGULATOR receiver
LK07_RS26165	COG2205	protein histidine kinase activity
LK07_RS26195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK07_RS26205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK07_RS26215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LK07_RS26220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK07_RS26230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LK07_RS26275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LK07_RS26280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LK07_RS26285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK07_RS26310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK07_RS26350	COG1131	(ABC) transporter
LK07_RS26355	COG2186	Transcriptional regulator
LK07_RS26360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK07_RS26375	COG0187	DNA topoisomerase II activity
LK07_RS26390	COG4585	Histidine kinase
LK07_RS26395	COG2197	response regulator
LK07_RS26405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK07_RS26415	COG4565	transcriptional regulatory protein
LK07_RS26420	COG3290	protein histidine kinase activity
LK07_RS26435	COG0372	Belongs to the citrate synthase family
LK07_RS26440	COG0523	cobalamin synthesis protein
LK07_RS26445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK07_RS26450	COG0612	Peptidase, M16
LK07_RS26465	COG1802	Transcriptional regulator
LK07_RS26470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK07_RS26480	COG0045	succinate-CoA ligase (ADP-forming) activity
LK07_RS26480	COG1042	CoA-binding domain protein
LK07_RS26480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK07_RS26495	COG1435	thymidine kinase activity
LK07_RS26520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LK07_RS26530	COG0745	RESPONSE REGULATOR receiver
LK07_RS26535	COG2205	protein histidine kinase activity
LK07_RS26560	COG0756	dUTP diphosphatase activity
LK07_RS26595	COG0569	domain protein
LK07_RS26600	COG0531	amino acid
LK07_RS26605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK07_RS26655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK07_RS26670	COG4974	Belongs to the 'phage' integrase family
LK07_RS26685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK07_RS26740	COG0156	8-amino-7-oxononanoate synthase activity
LK07_RS26745	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS26755	COG0604	alcohol dehydrogenase
LK07_RS26755	COG3321	synthase
LK07_RS26760	COG0477	Major facilitator Superfamily
LK07_RS26770	COG2197	response regulator
LK07_RS26855	COG2920	part of a sulfur-relay system
LK07_RS26860	COG1252	NADH dehydrogenase
LK07_RS26865	COG0500	methyltransferase
LK07_RS26875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK07_RS26905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK07_RS26920	COG1215	transferase activity, transferring glycosyl groups
LK07_RS26930	COG4310	Domain of unknown function (DUF2172)
LK07_RS26945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK07_RS26955	COG0438	transferase activity, transferring glycosyl groups
LK07_RS26980	COG0367	asparagine synthase
LK07_RS27000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LK07_RS27050	COG1595	DNA-templated transcription, initiation
LK07_RS27055	COG0531	amino acid
LK07_RS27075	COG1799	cell septum assembly
LK07_RS27125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LK07_RS27135	COG2235	arginine
LK07_RS27140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK07_RS27145	COG0531	amino acid
LK07_RS27155	COG1024	Enoyl-CoA hydratase
LK07_RS27190	COG2188	Transcriptional regulator
LK07_RS27195	COG2182	Extracellular solute-binding protein
LK07_RS27200	COG1175	transmembrane transport
LK07_RS27205	COG0395	ABC-type sugar transport system, permease component
LK07_RS27210	COG1472	Belongs to the glycosyl hydrolase 3 family
LK07_RS27280	COG2197	response regulator
LK07_RS27295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK07_RS27300	COG1960	acyl-CoA dehydrogenase activity
LK07_RS27310	COG0367	asparagine synthase
LK07_RS27325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK07_RS27330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK07_RS27355	COG0477	Major facilitator Superfamily
LK07_RS27365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK07_RS27375	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK07_RS27385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK07_RS27410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK07_RS27425	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS27440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK07_RS27465	COG2130	NADP-dependent
LK07_RS27475	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK07_RS27485	COG2368	4-hydroxyphenylacetate
LK07_RS27490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LK07_RS27540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK07_RS27550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK07_RS27560	COG1653	transport
LK07_RS27565	COG1175	transmembrane transport
LK07_RS27570	COG0395	ABC-type sugar transport system, permease component
LK07_RS27575	COG1940	carbohydrate kinase activity
LK07_RS27580	COG4213	ABC transporter substrate-binding protein
LK07_RS27590	COG4214	carbohydrate transport
LK07_RS27595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK07_RS27600	COG0531	amino acid
LK07_RS27625	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK07_RS27625	COG1024	Enoyl-CoA hydratase
LK07_RS27630	COG0183	Belongs to the thiolase family
LK07_RS27635	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LK07_RS27650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LK07_RS27665	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK07_RS27680	COG3253	May function as heme-dependent peroxidase
LK07_RS27695	COG3220	belongs to the UPF0276 family
LK07_RS27705	COG2801	Transposase and inactivated derivatives
LK07_RS27720	COG0330	HflC and HflK could
LK07_RS27765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK07_RS27770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK07_RS27785	COG1174	glycine betaine transport
LK07_RS27790	COG1174	glycine betaine transport
LK07_RS27805	COG2018	Roadblock/LC7 domain
LK07_RS27810	COG5002	protein histidine kinase activity
LK07_RS27860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK07_RS27870	COG3173	Aminoglycoside phosphotransferase
LK07_RS27935	COG2409	Drug exporters of the RND superfamily
LK07_RS27945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK07_RS27985	COG0529	Catalyzes the synthesis of activated sulfate
LK07_RS27990	COG0175	sulfate reduction
LK07_RS28020	COG1960	acyl-CoA dehydrogenase activity
LK07_RS28040	COG3739	integral membrane protein
LK07_RS28045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LK07_RS28065	COG2040	homocysteine
LK07_RS28075	COG1309	transcriptional regulator
LK07_RS28100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LK07_RS28105	COG1162	GTPase activity
LK07_RS28140	COG1802	Transcriptional regulator
LK07_RS28155	COG3835	regulator
LK07_RS28175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LK07_RS28180	COG2252	PERMEase
LK07_RS28195	COG0726	polysaccharide deacetylase
LK07_RS28215	COG1605	Chorismate mutase
LK07_RS28220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LK07_RS28220	COG0512	Glutamine amidotransferase of anthranilate synthase
LK07_RS28225	COG0287	Prephenate dehydrogenase
LK07_RS28230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK07_RS28235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK07_RS28255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK07_RS28265	COG1045	serine acetyltransferase
LK07_RS28280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK07_RS28305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LK07_RS28335	COG0598	Magnesium transport protein CorA
LK07_RS28355	COG2197	response regulator
LK07_RS28360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK07_RS28365	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS28375	COG3960	tartronate-semialdehyde synthase activity
LK07_RS28390	COG0753	catalase activity
LK07_RS28395	COG2084	Dehydrogenase
LK07_RS28400	COG3622	Belongs to the hyi family
LK07_RS28420	COG2351	hydroxyisourate hydrolase activity
LK07_RS28440	COG2233	PERMEase
LK07_RS28455	COG0406	alpha-ribazole phosphatase activity
LK07_RS28460	COG0436	Aminotransferase
LK07_RS28465	COG1733	regulation of RNA biosynthetic process
LK07_RS28480	COG4264	IucA IucC family
LK07_RS28485	COG4264	IucA IucC family
LK07_RS28525	COG2801	Transposase and inactivated derivatives
LK07_RS28540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LK07_RS28545	COG0746	molybdenum cofactor guanylyltransferase activity
LK07_RS28555	COG1414	Transcriptional regulator
LK07_RS28560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK07_RS28565	COG4266	Belongs to the allantoicase family
LK07_RS28585	COG0673	inositol 2-dehydrogenase activity
LK07_RS28590	COG2188	Transcriptional regulator
LK07_RS28610	COG1940	carbohydrate kinase activity
LK07_RS28620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK07_RS28640	COG1032	radical SAM domain protein
LK07_RS28645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LK07_RS28665	COG2814	Major facilitator Superfamily
LK07_RS28680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK07_RS28685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK07_RS28690	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LK07_RS28695	COG1063	alcohol dehydrogenase
LK07_RS28720	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS28725	COG4221	oxidoreductase activity
LK07_RS28740	COG0612	Peptidase, M16
LK07_RS28745	COG1132	(ABC) transporter
LK07_RS28805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK07_RS28810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK07_RS28835	COG0405	Gamma-glutamyltransferase
LK07_RS28840	COG0542	response to heat
LK07_RS28865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK07_RS28880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK07_RS28890	COG1953	Uracil, thiamine, allantoin
LK07_RS28900	COG0483	inositol monophosphate 1-phosphatase activity
LK07_RS28925	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LK07_RS28930	COG0569	domain protein
LK07_RS28930	COG0475	glutathione-regulated potassium exporter activity
LK07_RS28945	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LK07_RS28955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK07_RS28965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LK07_RS28975	COG1929	Belongs to the glycerate kinase type-1 family
LK07_RS28985	COG0688	phosphatidylethanolamine metabolic process
LK07_RS28990	COG1960	acyl-CoA dehydrogenase activity
LK07_RS29000	COG2301	Belongs to the HpcH HpaI aldolase family
LK07_RS29005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS29005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LK07_RS29020	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK07_RS29030	COG0596	Alpha beta hydrolase
LK07_RS29060	COG2362	D-Aminopeptidase
LK07_RS29065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK07_RS29075	COG1619	proteins homologs of microcin C7 resistance protein MccF
LK07_RS29100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK07_RS29115	COG2226	methyltransferase
LK07_RS29125	COG0488	(ABC) transporter
LK07_RS29160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK07_RS29180	COG0443	Heat shock 70 kDa protein
LK07_RS29200	COG2154	pterin-4-alpha-carbinolamine dehydratase
LK07_RS29205	COG2226	methyltransferase
LK07_RS29220	COG4221	oxidoreductase activity
LK07_RS29230	COG0656	L-ascorbic acid biosynthetic process
LK07_RS29240	COG0583	DNA-binding transcription factor activity
LK07_RS29255	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LK07_RS29260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK07_RS29305	COG3942	CHAP domain
LK07_RS29305	COG1388	LysM domain
LK07_RS29330	COG0438	transferase activity, transferring glycosyl groups
LK07_RS29350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK07_RS29355	COG0477	Major facilitator Superfamily
LK07_RS29370	COG0438	transferase activity, transferring glycosyl groups
LK07_RS29400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LK07_RS29405	COG0166	Belongs to the GPI family
LK07_RS29420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK07_RS29455	COG1486	melibiose metabolic process
LK07_RS29460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LK07_RS29490	COG0791	NLP P60 protein
LK07_RS29490	COG3883	PFAM NLP P60 protein
LK07_RS29505	COG3629	intracellular signal transduction
LK07_RS29505	COG3903	Transcriptional regulator
LK07_RS29520	COG3511	phospholipase C
LK07_RS29555	COG1470	cell adhesion involved in biofilm formation
LK07_RS29560	COG1793	dna ligase
LK07_RS29595	COG1834	amidinotransferase
LK07_RS29600	COG0488	(ABC) transporter
LK07_RS29615	COG1515	deoxyribonuclease V activity
LK07_RS29625	COG3268	Saccharopine dehydrogenase
LK07_RS29635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK07_RS29640	COG0183	Belongs to the thiolase family
LK07_RS29645	COG1024	Enoyl-CoA hydratase
LK07_RS29645	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK07_RS29655	COG1113	amino acid transport
LK07_RS29665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK07_RS29675	COG0488	(ABC) transporter
LK07_RS29680	COG2183	response to ionizing radiation
LK07_RS29685	COG1024	Enoyl-CoA hydratase
LK07_RS29695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LK07_RS29735	COG1134	teichoic acid transport
LK07_RS29740	COG1562	ergosterol biosynthetic process
LK07_RS29750	COG1233	COG1233 Phytoene dehydrogenase and related
LK07_RS29760	COG1657	PFAM Prenyltransferase squalene oxidase
LK07_RS29775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK07_RS29815	COG2755	lipolytic protein G-D-S-L family
LK07_RS29860	COG1063	alcohol dehydrogenase
LK07_RS29865	COG0156	8-amino-7-oxononanoate synthase activity
LK07_RS29870	COG0583	DNA-binding transcription factor activity
LK07_RS29880	COG3958	Transketolase
LK07_RS29885	COG3959	Transketolase, thiamine diphosphate binding domain
LK07_RS29930	COG0174	glutamine synthetase
LK07_RS29945	COG2267	carboxylic ester hydrolase activity
LK07_RS29950	COG0183	Belongs to the thiolase family
LK07_RS30010	COG0395	ABC-type sugar transport system, permease component
LK07_RS30020	COG1653	transport
LK07_RS30030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK07_RS30035	COG1131	(ABC) transporter
LK07_RS30070	COG0673	inositol 2-dehydrogenase activity
LK07_RS30090	COG0673	inositol 2-dehydrogenase activity
LK07_RS30095	COG1609	Transcriptional regulator
LK07_RS30110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK07_RS30125	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS30140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK07_RS30155	COG2197	response regulator
LK07_RS30200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK07_RS30240	COG0431	NADPH-dependent FMN reductase
LK07_RS30250	COG2223	nitrite transmembrane transporter activity
LK07_RS30255	COG2207	Transcriptional regulator
LK07_RS30265	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS30270	COG1846	Transcriptional regulator
LK07_RS30315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LK07_RS30330	COG1454	alcohol dehydrogenase
LK07_RS30330	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS30340	COG0531	amino acid
LK07_RS30350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK07_RS30355	COG0549	Belongs to the carbamate kinase family
LK07_RS30370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK07_RS30380	COG0076	glutamate decarboxylase activity
LK07_RS30400	COG1309	transcriptional regulator
LK07_RS30405	COG2409	Drug exporters of the RND superfamily
LK07_RS30420	COG2340	Cysteine-rich secretory protein family
LK07_RS30435	COG0604	alcohol dehydrogenase
LK07_RS30435	COG3321	synthase
LK07_RS30450	COG0604	alcohol dehydrogenase
LK07_RS30450	COG3321	synthase
LK07_RS30465	COG2124	cytochrome p450
LK07_RS30480	COG0142	geranyltranstransferase activity
LK07_RS30485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK07_RS30490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK07_RS30500	COG1090	epimerase
LK07_RS30515	COG2837	iron assimilation
LK07_RS30580	COG2755	lipolytic protein G-D-S-L family
LK07_RS30615	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS30620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LK07_RS30625	COG1012	belongs to the aldehyde dehydrogenase family
LK07_RS30640	COG1940	carbohydrate kinase activity
LK07_RS30640	COG1846	Transcriptional regulator
LK07_RS30685	COG2018	Roadblock/LC7 domain
LK07_RS30695	COG1946	Acyl-CoA thioesterase
LK07_RS30710	COG0254	rRNA binding
LK07_RS30730	COG1132	(ABC) transporter
LK07_RS30740	COG2072	flavoprotein involved in K transport
LK07_RS30745	COG0432	Pfam Uncharacterised protein family UPF0047
LK07_RS30755	COG4232	protein-disulfide reductase activity
LK07_RS30780	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS30785	COG0300	oxidoreductase activity
LK07_RS30810	COG4566	intracellular signal transduction
LK07_RS30830	COG0477	Major facilitator Superfamily
LK07_RS30845	COG2706	6-phosphogluconolactonase activity
LK07_RS30855	COG2971	BadF BadG BcrA BcrD
LK07_RS30860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK07_RS30865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK07_RS30880	COG1960	acyl-CoA dehydrogenase activity
LK07_RS30930	COG1846	Transcriptional regulator
LK07_RS30945	COG0584	glycerophosphoryl diester phosphodiesterase
LK07_RS30965	COG0204	Acyl-transferase
LK07_RS30985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LK07_RS31010	COG1660	Displays ATPase and GTPase activities
LK07_RS31025	COG0445	tRNA wobble uridine modification
LK07_RS31045	COG1349	DNA-binding transcription factor activity
LK07_RS31050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK07_RS31060	COG2813	Specifically methylates the guanine in position
LK07_RS31070	COG1940	carbohydrate kinase activity
LK07_RS31115	COG1349	DNA-binding transcription factor activity
LK07_RS31150	COG0463	Glycosyl transferase, family 2
LK07_RS31155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LK07_RS31180	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS31220	COG2326	polyphosphate kinase activity
LK07_RS31245	COG1042	CoA-binding domain protein
LK07_RS31245	COG0045	succinate-CoA ligase (ADP-forming) activity
LK07_RS31245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK07_RS31305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK07_RS31345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK07_RS31350	COG1993	acr, cog1993
LK07_RS31355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK07_RS31360	COG1968	undecaprenyl-diphosphatase activity
LK07_RS31365	COG2186	Transcriptional regulator
LK07_RS31380	COG2066	Belongs to the glutaminase family
LK07_RS31390	COG5650	phosphatidylinositol metabolic process
LK07_RS31395	COG1686	Belongs to the peptidase S11 family
LK07_RS31400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LK07_RS31410	COG2226	methyltransferase
LK07_RS31415	COG2188	Transcriptional regulator
LK07_RS31420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK07_RS31425	COG3458	cephalosporin-C deacetylase activity
LK07_RS31440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LK07_RS31480	COG1902	pentaerythritol trinitrate reductase activity
LK07_RS31480	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK07_RS31505	COG1461	Dihydroxyacetone kinase
LK07_RS31510	COG2376	Dihydroxyacetone kinase
LK07_RS31525	COG1960	acyl-CoA dehydrogenase activity
LK07_RS31535	COG0477	Major facilitator Superfamily
LK07_RS31550	COG1309	transcriptional regulator
LK07_RS31575	COG2070	2-Nitropropane dioxygenase
LK07_RS31585	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS31615	COG1024	Enoyl-CoA hydratase
LK07_RS31660	COG0510	thiamine kinase activity
LK07_RS31685	COG2267	carboxylic ester hydrolase activity
LK07_RS31690	COG0367	asparagine synthase
LK07_RS31730	COG2409	Drug exporters of the RND superfamily
LK07_RS31760	COG0346	lactoylglutathione lyase activity
LK07_RS31765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK07_RS31775	COG0583	DNA-binding transcription factor activity
LK07_RS31795	COG1716	ATPase activity
LK07_RS31795	COG1131	(ABC) transporter
LK07_RS31795	COG0842	Transport permease protein
LK07_RS31805	COG2815	serine threonine protein kinase
LK07_RS31805	COG0515	serine threonine protein kinase
LK07_RS31835	COG0328	RNA-DNA hybrid ribonuclease activity
LK07_RS31840	COG2304	oxidoreductase activity
LK07_RS31875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK07_RS31875	COG0515	serine threonine protein kinase
LK07_RS31905	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LK07_RS31905	COG1672	PFAM Archaeal ATPase
LK07_RS31915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK07_RS31965	COG1252	NADH dehydrogenase
LK07_RS31980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LK07_RS31985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK07_RS31990	COG3281	Trehalose synthase
LK07_RS32000	COG0366	Alpha amylase catalytic
LK07_RS32040	COG0181	hydroxymethylbilane synthase activity
LK07_RS32090	COG0009	L-threonylcarbamoyladenylate synthase
LK07_RS32110	COG2409	Drug exporters of the RND superfamily
LK07_RS32135	COG3001	Fructosamine kinase
LK07_RS32165	COG0583	DNA-binding transcription factor activity
LK07_RS32170	COG3291	Pkd domain containing protein
LK07_RS32195	COG0667	Aldo Keto reductase
LK07_RS32220	COG0438	transferase activity, transferring glycosyl groups
LK07_RS32230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK07_RS32235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK07_RS32240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK07_RS32275	COG1024	Enoyl-CoA hydratase
LK07_RS32275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK07_RS32280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LK07_RS32290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LK07_RS32295	COG0298	carbon dioxide binding
LK07_RS32310	COG0375	protein maturation
LK07_RS32335	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LK07_RS32370	COG0701	Predicted permease
LK07_RS32385	COG1316	TRANSCRIPTIONal
LK07_RS32400	COG1090	epimerase
LK07_RS32415	COG3511	phospholipase C
LK07_RS32425	COG0456	acetyltransferase
LK07_RS32460	COG0745	RESPONSE REGULATOR receiver
LK07_RS32465	COG2205	protein histidine kinase activity
LK07_RS32470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK07_RS32490	COG3844	kynureninase activity
LK07_RS32500	COG3483	tryptophan 2,3-dioxygenase activity
LK07_RS32505	COG1028	Short-chain dehydrogenase reductase Sdr
LK07_RS32510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK07_RS32520	COG3396	Phenylacetate-CoA oxygenase
LK07_RS32525	COG3460	Phenylacetate-CoA oxygenase
LK07_RS32530	COG3396	Phenylacetate-CoA oxygenase
LK07_RS32540	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS32545	COG0604	alcohol dehydrogenase
LK07_RS32555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK07_RS32565	COG1595	DNA-templated transcription, initiation
LK07_RS32615	COG1366	Belongs to the anti-sigma-factor antagonist family
LK07_RS32615	COG2208	phosphoserine phosphatase activity
LK07_RS32615	COG2172	sigma factor antagonist activity
LK07_RS32625	COG0588	phosphoglycerate mutase activity
LK07_RS32630	COG1070	Carbohydrate kinase
LK07_RS32635	COG1070	Carbohydrate kinase
LK07_RS32650	COG4213	ABC transporter substrate-binding protein
LK07_RS32655	COG1349	DNA-binding transcription factor activity
LK07_RS32670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK07_RS32685	COG1280	lysine exporter protein (LysE YggA)
LK07_RS32700	COG1309	transcriptional regulator
LK07_RS32735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK07_RS32800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK07_RS32815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LK07_RS32820	COG0022	dehydrogenase e1 component
LK07_RS32855	COG0583	DNA-binding transcription factor activity
LK07_RS32875	COG0321	lipoyl(octanoyl) transferase activity
LK07_RS32875	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LK07_RS32905	COG2197	response regulator
LK07_RS32925	COG0318	PFAM AMP-dependent synthetase and ligase
LK07_RS32935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK07_RS32945	COG1131	(ABC) transporter
LK07_RS32985	COG3511	phospholipase C
LK07_RS33025	COG1869	D-ribose catabolic process
LK07_RS33030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK07_RS33040	COG1129	ABC transporter
LK07_RS33060	COG2197	response regulator
LK07_RS33085	COG0602	queuosine metabolic process
LK07_RS33090	COG0720	synthase
LK07_RS33095	COG0302	gtp cyclohydrolase
LK07_RS33115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK07_RS33120	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LK07_RS33130	COG4865	methylaspartate mutase activity
LK07_RS33165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK07_RS33175	COG2801	Transposase and inactivated derivatives
LK07_RS33220	COG4974	Belongs to the 'phage' integrase family
LK07_RS33235	COG1674	ftsk spoiiie
LK07_RS33245	COG2188	Transcriptional regulator
LK07_RS33290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK07_RS33315	COG1695	Transcriptional regulator
LK07_RS33320	COG3328	transposase activity