locus-tag	class	description
CP972_RS00145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP972_RS00150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP972_RS00220	COG1278	Cold shock
CP972_RS00295	COG2828	Protein conserved in bacteria
CP972_RS00300	COG2159	amidohydrolase
CP972_RS00315	COG0477	Major facilitator Superfamily
CP972_RS00315	COG2814	Major facilitator Superfamily
CP972_RS00325	COG0745	RESPONSE REGULATOR receiver
CP972_RS00330	COG2205	protein histidine kinase activity
CP972_RS00335	COG2409	Drug exporters of the RND superfamily
CP972_RS00400	COG3547	Transposase (IS116 IS110 IS902 family)
CP972_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS00610	COG0493	'glutamate synthase
CP972_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS00655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP972_RS00665	COG0473	3-isopropylmalate dehydrogenase activity
CP972_RS00705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CP972_RS00740	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CP972_RS00745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CP972_RS00750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CP972_RS00765	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP972_RS00775	COG0300	oxidoreductase activity
CP972_RS00920	COG3209	COG3209 Rhs family protein
CP972_RS00955	COG1309	transcriptional regulator
CP972_RS00960	COG1725	Transcriptional regulator
CP972_RS00965	COG3842	ATPase activity
CP972_RS01015	COG0657	acetylesterase activity
CP972_RS01020	COG1309	transcriptional regulator
CP972_RS01040	COG0302	gtp cyclohydrolase
CP972_RS01060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP972_RS01150	COG3629	intracellular signal transduction
CP972_RS01150	COG3903	Transcriptional regulator
CP972_RS01155	COG0596	Alpha beta hydrolase
CP972_RS01180	COG2801	Transposase and inactivated derivatives
CP972_RS01255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP972_RS01265	COG0798	PFAM Bile acid sodium symporter
CP972_RS01270	COG2072	flavoprotein involved in K transport
CP972_RS01285	COG0640	Transcriptional regulator
CP972_RS01325	COG1595	DNA-templated transcription, initiation
CP972_RS01430	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS01435	COG0156	8-amino-7-oxononanoate synthase activity
CP972_RS01440	COG1132	(ABC) transporter
CP972_RS01445	COG1132	(ABC) transporter
CP972_RS01450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP972_RS01460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP972_RS01480	COG2192	nodulation
CP972_RS01500	COG1131	(ABC) transporter
CP972_RS01515	COG1215	transferase activity, transferring glycosyl groups
CP972_RS01520	COG1086	Polysaccharide biosynthesis protein
CP972_RS01540	COG3693	PFAM glycoside hydrolase, family 10
CP972_RS01625	COG2801	Transposase and inactivated derivatives
CP972_RS01715	COG2755	lipolytic protein G-D-S-L family
CP972_RS01760	COG3118	belongs to the thioredoxin family
CP972_RS01800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP972_RS01805	COG1335	isochorismatase
CP972_RS01870	COG2409	Drug exporters of the RND superfamily
CP972_RS01930	COG2208	phosphoserine phosphatase activity
CP972_RS01930	COG2770	Histidine kinase
CP972_RS01935	COG1366	Belongs to the anti-sigma-factor antagonist family
CP972_RS01960	COG3655	Transcriptional regulator
CP972_RS01995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP972_RS02020	COG1131	(ABC) transporter
CP972_RS02035	COG0513	Belongs to the DEAD box helicase family
CP972_RS02065	COG2255	four-way junction helicase activity
CP972_RS02070	COG0632	four-way junction helicase activity
CP972_RS02075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP972_RS02080	COG2132	Multicopper oxidase
CP972_RS02090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP972_RS02105	COG2340	Cysteine-rich secretory protein family
CP972_RS02120	COG2268	Band 7 protein
CP972_RS02130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP972_RS02145	COG1595	DNA-templated transcription, initiation
CP972_RS02175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP972_RS02180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP972_RS02260	COG1940	carbohydrate kinase activity
CP972_RS02275	COG2318	DinB family
CP972_RS02320	COG0395	ABC-type sugar transport system, permease component
CP972_RS02345	COG2205	protein histidine kinase activity
CP972_RS02350	COG0745	RESPONSE REGULATOR receiver
CP972_RS02390	COG1609	Transcriptional regulator
CP972_RS02395	COG1879	ABC-type sugar transport system periplasmic component
CP972_RS02400	COG1129	ABC transporter
CP972_RS02405	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP972_RS02410	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP972_RS02430	COG2318	DinB family
CP972_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS02460	COG1309	transcriptional regulator
CP972_RS02470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP972_RS02475	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CP972_RS02475	COG2508	Transcriptional regulator
CP972_RS02485	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CP972_RS02490	COG0745	RESPONSE REGULATOR receiver
CP972_RS02585	COG0277	FAD linked oxidase domain protein
CP972_RS02630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP972_RS02645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP972_RS02655	COG0438	transferase activity, transferring glycosyl groups
CP972_RS02755	COG2409	Drug exporters of the RND superfamily
CP972_RS02765	COG3397	chitin binding
CP972_RS02790	COG0659	secondary active sulfate transmembrane transporter activity
CP972_RS02800	COG1063	alcohol dehydrogenase
CP972_RS02815	COG0753	catalase activity
CP972_RS02820	COG0009	L-threonylcarbamoyladenylate synthase
CP972_RS02830	COG0656	L-ascorbic acid biosynthetic process
CP972_RS02855	COG0181	hydroxymethylbilane synthase activity
CP972_RS02895	COG0366	Alpha amylase catalytic
CP972_RS02910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP972_RS02935	COG1366	Belongs to the anti-sigma-factor antagonist family
CP972_RS02940	COG1366	Belongs to the anti-sigma-factor antagonist family
CP972_RS02945	COG2172	sigma factor antagonist activity
CP972_RS02960	COG1252	NADH dehydrogenase
CP972_RS02990	COG0477	Major facilitator Superfamily
CP972_RS03000	COG0583	DNA-binding transcription factor activity
CP972_RS03040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP972_RS03065	COG0667	Aldo Keto reductase
CP972_RS03070	COG0328	RNA-DNA hybrid ribonuclease activity
CP972_RS03090	COG0740	serine-type endopeptidase activity
CP972_RS03095	COG0740	serine-type endopeptidase activity
CP972_RS03105	COG1191	sigma factor activity
CP972_RS03145	COG1131	(ABC) transporter
CP972_RS03145	COG1716	ATPase activity
CP972_RS03145	COG0842	Transport permease protein
CP972_RS03155	COG0667	Aldo Keto reductase
CP972_RS03160	COG0583	DNA-binding transcription factor activity
CP972_RS03170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP972_RS03190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS03200	COG0431	NADPH-dependent FMN reductase
CP972_RS03290	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS03295	COG2366	antibiotic biosynthetic process
CP972_RS03310	COG0515	serine threonine protein kinase
CP972_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS03360	COG1733	regulation of RNA biosynthetic process
CP972_RS03365	COG2084	Dehydrogenase
CP972_RS03370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CP972_RS03375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP972_RS03395	COG1063	alcohol dehydrogenase
CP972_RS03460	COG2801	Transposase and inactivated derivatives
CP972_RS03580	COG2124	cytochrome p450
CP972_RS03625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP972_RS03635	COG1132	(ABC) transporter
CP972_RS03685	COG3387	PFAM Glycoside hydrolase 15-related
CP972_RS03710	COG4974	Belongs to the 'phage' integrase family
CP972_RS03750	COG0494	nUDIX hydrolase
CP972_RS03755	COG2264	protein methyltransferase activity
CP972_RS03910	COG0738	Major facilitator superfamily
CP972_RS03915	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP972_RS04180	COG0287	Prephenate dehydrogenase
CP972_RS04185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP972_RS04185	COG0512	Glutamine amidotransferase of anthranilate synthase
CP972_RS04190	COG1605	Chorismate mutase
CP972_RS04195	COG2890	protein-(glutamine-N5) methyltransferase activity
CP972_RS04225	COG3483	tryptophan 2,3-dioxygenase activity
CP972_RS04240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP972_RS04245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP972_RS04260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP972_RS04275	COG3251	PFAM MbtH domain protein
CP972_RS04295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS04300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP972_RS04305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP972_RS04320	COG2801	Transposase and inactivated derivatives
CP972_RS04325	COG2826	transposase and inactivated derivatives, IS30 family
CP972_RS04370	COG2376	Dihydroxyacetone kinase
CP972_RS04375	COG1461	Dihydroxyacetone kinase
CP972_RS04380	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CP972_RS04405	COG1902	pentaerythritol trinitrate reductase activity
CP972_RS04405	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP972_RS04420	COG2890	protein-(glutamine-N5) methyltransferase activity
CP972_RS04425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP972_RS04435	COG3458	cephalosporin-C deacetylase activity
CP972_RS04440	COG2188	Transcriptional regulator
CP972_RS04445	COG2226	methyltransferase
CP972_RS04455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CP972_RS04460	COG1686	Belongs to the peptidase S11 family
CP972_RS04470	COG2186	Transcriptional regulator
CP972_RS04475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP972_RS04480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP972_RS04505	COG1175	transmembrane transport
CP972_RS04510	COG0395	ABC-type sugar transport system, permease component
CP972_RS04565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP972_RS04570	COG2867	negative regulation of translational initiation
CP972_RS04580	COG2226	methyltransferase
CP972_RS04600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP972_RS04600	COG0515	serine threonine protein kinase
CP972_RS04605	COG2814	Major facilitator Superfamily
CP972_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS04660	COG1215	transferase activity, transferring glycosyl groups
CP972_RS04690	COG1349	DNA-binding transcription factor activity
CP972_RS04710	COG3467	pyridoxamine 5'-phosphate
CP972_RS04720	COG1940	carbohydrate kinase activity
CP972_RS04730	COG2813	Specifically methylates the guanine in position
CP972_RS04735	COG3387	PFAM Glycoside hydrolase 15-related
CP972_RS04760	COG4565	transcriptional regulatory protein
CP972_RS04765	COG3290	protein histidine kinase activity
CP972_RS04840	COG1660	Displays ATPase and GTPase activities
CP972_RS04870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP972_RS04885	COG0204	Acyl-transferase
CP972_RS04910	COG0584	glycerophosphoryl diester phosphodiesterase
CP972_RS04985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP972_RS05000	COG2706	6-phosphogluconolactonase activity
CP972_RS05015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP972_RS05070	COG0589	response to stress
CP972_RS05075	COG1309	transcriptional regulator
CP972_RS05090	COG1063	alcohol dehydrogenase
CP972_RS05100	COG0432	Pfam Uncharacterised protein family UPF0047
CP972_RS05105	COG2072	flavoprotein involved in K transport
CP972_RS05110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP972_RS05115	COG1132	(ABC) transporter
CP972_RS05125	COG1132	(ABC) transporter
CP972_RS05130	COG1132	(ABC) transporter
CP972_RS05140	COG0254	rRNA binding
CP972_RS05155	COG1946	Acyl-CoA thioesterase
CP972_RS05165	COG2018	Roadblock/LC7 domain
CP972_RS05200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP972_RS05250	COG1960	acyl-CoA dehydrogenase activity
CP972_RS05255	COG1960	acyl-CoA dehydrogenase activity
CP972_RS05275	COG1793	dna ligase
CP972_RS05280	COG1051	belongs to the nudix hydrolase family
CP972_RS05285	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS05315	COG1960	acyl-CoA dehydrogenase activity
CP972_RS05325	COG0242	peptide deformylase activity
CP972_RS05330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP972_RS05335	COG3442	glutamine amidotransferase
CP972_RS05340	COG0205	6-phosphofructokinase activity
CP972_RS05355	COG3275	phosphorelay sensor kinase activity
CP972_RS05360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP972_RS05370	COG3279	Response regulator of the LytR AlgR family
CP972_RS05375	COG1522	sequence-specific DNA binding
CP972_RS05380	COG1834	amidinotransferase
CP972_RS05385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP972_RS05405	COG0204	Acyl-transferase
CP972_RS05415	COG0740	serine-type endopeptidase activity
CP972_RS05445	COG0156	8-amino-7-oxononanoate synthase activity
CP972_RS05450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP972_RS05455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP972_RS05460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP972_RS05465	COG2226	methyltransferase
CP972_RS05475	COG0577	efflux transmembrane transporter activity
CP972_RS05500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP972_RS05505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP972_RS05520	COG4585	Histidine kinase
CP972_RS05525	COG2197	response regulator
CP972_RS05530	COG1940	carbohydrate kinase activity
CP972_RS05535	COG2188	Transcriptional regulator
CP972_RS05540	COG1595	DNA-templated transcription, initiation
CP972_RS05545	COG2267	carboxylic ester hydrolase activity
CP972_RS05560	COG0626	cystathionine gamma-synthase activity
CP972_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS05585	COG0419	ATPase involved in DNA repair
CP972_RS05590	COG0420	3'-5' exonuclease activity
CP972_RS05595	COG1739	Uncharacterized protein family UPF0029
CP972_RS05610	COG1832	CoA-binding protein
CP972_RS05625	COG0501	Belongs to the peptidase M48B family
CP972_RS05635	COG0640	Transcriptional regulator
CP972_RS05650	COG0110	maltose O-acetyltransferase activity
CP972_RS05660	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CP972_RS05695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP972_RS05705	COG1968	undecaprenyl-diphosphatase activity
CP972_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS05725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CP972_RS05745	COG2318	DinB family
CP972_RS05760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP972_RS05765	COG0747	negative chemotaxis
CP972_RS05820	COG1940	carbohydrate kinase activity
CP972_RS05825	COG2182	Extracellular solute-binding protein
CP972_RS05830	COG1175	transmembrane transport
CP972_RS05835	COG0395	ABC-type sugar transport system, permease component
CP972_RS05840	COG2723	6-phospho-beta-galactosidase activity
CP972_RS05850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP972_RS05860	COG0723	plastoquinol--plastocyanin reductase activity
CP972_RS05930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP972_RS05930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP972_RS05940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CP972_RS05960	COG1716	ATPase activity
CP972_RS05980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP972_RS06015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP972_RS06025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP972_RS06040	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CP972_RS06060	COG2018	Roadblock/LC7 domain
CP972_RS06120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP972_RS06125	COG2364	Membrane
CP972_RS06130	COG0584	glycerophosphoryl diester phosphodiesterase
CP972_RS06135	COG2270	Major facilitator Superfamily
CP972_RS06145	COG3030	protein affecting phage T7 exclusion by the F plasmid
CP972_RS06150	COG1216	Glycosyl transferase, family 2
CP972_RS06175	COG1960	acyl-CoA dehydrogenase activity
CP972_RS06210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP972_RS06215	COG0140	phosphoribosyl-ATP diphosphatase activity
CP972_RS06220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP972_RS06225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP972_RS06225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP972_RS06230	COG3201	nicotinamide mononucleotide transporter
CP972_RS06245	COG1846	Transcriptional regulator
CP972_RS06245	COG1940	carbohydrate kinase activity
CP972_RS06250	COG2223	nitrite transmembrane transporter activity
CP972_RS06255	COG2233	PERMEase
CP972_RS06270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP972_RS06290	COG2390	Transcriptional regulator
CP972_RS06295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP972_RS06305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP972_RS06320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP972_RS06330	COG1758	RNA polymerase activity
CP972_RS06335	COG0194	GDP metabolic process
CP972_RS06345	COG0284	orotidine-5'-phosphate decarboxylase activity
CP972_RS06350	COG0167	dihydroorotate dehydrogenase activity
CP972_RS06355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP972_RS06360	COG0505	Belongs to the CarA family
CP972_RS06370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP972_RS06375	COG0540	Belongs to the ATCase OTCase family
CP972_RS06380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CP972_RS06390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP972_RS06395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP972_RS06400	COG0006	proline dipeptidase activity
CP972_RS06410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP972_RS06415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP972_RS06420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP972_RS06425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP972_RS06440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP972_RS06445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP972_RS06465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP972_RS06480	COG0124	histidyl-tRNA synthetase
CP972_RS06490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CP972_RS06495	COG1196	nuclear chromosome segregation
CP972_RS06500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP972_RS06505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP972_RS06510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP972_RS06515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP972_RS06525	COG2255	four-way junction helicase activity
CP972_RS06530	COG0632	four-way junction helicase activity
CP972_RS06535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP972_RS06540	COG0217	transcriptional regulatory protein
CP972_RS06545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CP972_RS06550	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CP972_RS06560	COG0438	transferase activity, transferring glycosyl groups
CP972_RS06565	COG1560	Kdo2-lipid A biosynthetic process
CP972_RS06570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP972_RS06590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP972_RS06615	COG0395	ABC-type sugar transport system, permease component
CP972_RS06620	COG1175	transmembrane transport
CP972_RS06670	COG0512	Glutamine amidotransferase of anthranilate synthase
CP972_RS06670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP972_RS06730	COG1216	Glycosyl transferase, family 2
CP972_RS06735	COG0667	Aldo Keto reductase
CP972_RS06745	COG1215	transferase activity, transferring glycosyl groups
CP972_RS06750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP972_RS06755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP972_RS06760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP972_RS06775	COG2197	response regulator
CP972_RS06785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP972_RS06785	COG1648	precorrin-2 dehydrogenase activity
CP972_RS06790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP972_RS06805	COG1464	Belongs to the NlpA lipoprotein family
CP972_RS06810	COG2011	ABC-type metal ion transport system permease component
CP972_RS06845	COG0584	glycerophosphoryl diester phosphodiesterase
CP972_RS06850	COG0204	Acyl-transferase
CP972_RS06850	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS06855	COG0477	Major facilitator Superfamily
CP972_RS06870	COG0165	Argininosuccinate lyase
CP972_RS06875	COG0137	argininosuccinate synthase activity
CP972_RS06905	COG1438	arginine binding
CP972_RS06910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP972_RS06915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP972_RS06920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP972_RS06925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP972_RS06940	COG0745	RESPONSE REGULATOR receiver
CP972_RS06980	COG0640	Transcriptional regulator
CP972_RS06985	COG0346	lactoylglutathione lyase activity
CP972_RS06995	COG2259	Doxx family
CP972_RS07020	COG0697	spore germination
CP972_RS07030	COG1649	PFAM Uncharacterised BCR, COG1649
CP972_RS07060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP972_RS07060	COG0072	phenylalanine-tRNA ligase activity
CP972_RS07065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP972_RS07070	COG5002	protein histidine kinase activity
CP972_RS07075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP972_RS07080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP972_RS07085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP972_RS07090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP972_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS07135	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS07140	COG0174	glutamine synthetase
CP972_RS07165	COG4176	ABC-type proline glycine betaine transport system permease component
CP972_RS07170	COG4175	Glycine betaine
CP972_RS07170	COG0517	IMP dehydrogenase activity
CP972_RS07175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP972_RS07190	COG0564	pseudouridine synthase activity
CP972_RS07230	COG0805	protein transport
CP972_RS07235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP972_RS07255	COG2378	regulation of single-species biofilm formation
CP972_RS07265	COG0545	Peptidyl-prolyl cis-trans isomerase
CP972_RS07270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP972_RS07280	COG1609	Transcriptional regulator
CP972_RS07285	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP972_RS07290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP972_RS07305	COG4122	O-methyltransferase activity
CP972_RS07310	COG1222	aaa ATPase
CP972_RS07335	COG1994	Peptidase M50
CP972_RS07335	COG0517	IMP dehydrogenase activity
CP972_RS07345	COG2197	response regulator
CP972_RS07350	COG4166	transmembrane transport
CP972_RS07355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP972_RS07360	COG0646	methionine synthase
CP972_RS07360	COG1410	methionine synthase
CP972_RS07365	COG1414	Transcriptional regulator
CP972_RS07370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP972_RS07375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP972_RS07380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP972_RS07390	COG0215	cysteine-tRNA ligase activity
CP972_RS07410	COG0598	Magnesium transport protein CorA
CP972_RS07420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS07425	COG0667	Aldo Keto reductase
CP972_RS07455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP972_RS07465	COG3012	SEC-C Motif Domain Protein
CP972_RS07485	COG2186	Transcriptional regulator
CP972_RS07490	COG3265	gluconokinase activity
CP972_RS07510	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP972_RS07515	COG2149	membrane
CP972_RS07535	COG1960	acyl-CoA dehydrogenase activity
CP972_RS07550	COG3876	Protein conserved in bacteria
CP972_RS07580	COG1960	acyl-CoA dehydrogenase activity
CP972_RS07605	COG0243	molybdopterin cofactor binding
CP972_RS07610	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP972_RS07615	COG2188	Transcriptional regulator
CP972_RS07635	COG1595	DNA-templated transcription, initiation
CP972_RS07660	COG2755	lipolytic protein G-D-S-L family
CP972_RS07680	COG0726	polysaccharide deacetylase
CP972_RS07690	COG1725	Transcriptional regulator
CP972_RS07735	COG1799	cell septum assembly
CP972_RS07740	COG1960	acyl-CoA dehydrogenase activity
CP972_RS07745	COG0477	Major facilitator Superfamily
CP972_RS07755	COG0671	phosphoesterase, PA-phosphatase related
CP972_RS07780	COG1160	GTP binding
CP972_RS07790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP972_RS07820	COG1056	cytidyltransferase-related domain
CP972_RS07820	COG1051	belongs to the nudix hydrolase family
CP972_RS07825	COG1187	pseudouridine synthase activity
CP972_RS07830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP972_RS07835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP972_RS07850	COG0686	Belongs to the AlaDH PNT family
CP972_RS07860	COG0494	nUDIX hydrolase
CP972_RS07865	COG0504	CTP synthase activity
CP972_RS07870	COG3387	PFAM Glycoside hydrolase 15-related
CP972_RS07880	COG0497	DNA recombination
CP972_RS07885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP972_RS07905	COG1120	ATPase activity
CP972_RS07910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP972_RS07915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP972_RS07920	COG0647	UMP catabolic process
CP972_RS07965	COG2094	Belongs to the DNA glycosylase MPG family
CP972_RS07975	COG1881	PFAM PEBP family protein
CP972_RS07995	COG1119	ATPase activity
CP972_RS08010	COG2197	response regulator
CP972_RS08025	COG1131	(ABC) transporter
CP972_RS08025	COG1716	ATPase activity
CP972_RS08025	COG0842	Transport permease protein
CP972_RS08035	COG0560	Phosphoserine phosphatase
CP972_RS08035	COG3830	Belongs to the UPF0237 family
CP972_RS08040	COG0588	phosphoglycerate mutase activity
CP972_RS08055	COG2807	transmembrane transport
CP972_RS08060	COG2186	Transcriptional regulator
CP972_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS08080	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
CP972_RS08095	COG1401	restriction endodeoxyribonuclease activity
CP972_RS08130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP972_RS08135	COG1111	helicase
CP972_RS08135	COG1205	dead DEAH box helicase
CP972_RS08150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP972_RS08170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP972_RS08175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP972_RS08190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP972_RS08200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP972_RS08220	COG3387	PFAM Glycoside hydrolase 15-related
CP972_RS08235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CP972_RS08240	COG1869	D-ribose catabolic process
CP972_RS08245	COG1129	ABC transporter
CP972_RS08255	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP972_RS08260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP972_RS08295	COG1024	Enoyl-CoA hydratase
CP972_RS08305	COG0488	(ABC) transporter
CP972_RS08325	COG0235	Class ii aldolase
CP972_RS08340	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CP972_RS08345	COG1492	cobalamin metabolic process
CP972_RS08360	COG1797	cobyrinic acid a,c-diamide synthase activity
CP972_RS08390	COG0765	amino acid transport
CP972_RS08400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CP972_RS08405	COG0456	acetyltransferase
CP972_RS08410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP972_RS08415	COG1917	Cupin 2, conserved barrel domain protein
CP972_RS08420	COG5285	phytanoyl-CoA dioxygenase
CP972_RS08425	COG3844	kynureninase activity
CP972_RS08450	COG1414	Transcriptional regulator
CP972_RS08455	COG1595	DNA-templated transcription, initiation
CP972_RS08475	COG4677	pectinesterase activity
CP972_RS08480	COG3866	Pectate lyase
CP972_RS08485	COG2755	lipolytic protein G-D-S-L family
CP972_RS08495	COG3507	Belongs to the glycosyl hydrolase 43 family
CP972_RS08510	COG0395	ABC-type sugar transport system, permease component
CP972_RS08525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP972_RS08545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP972_RS08550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP972_RS08555	COG1349	DNA-binding transcription factor activity
CP972_RS08570	COG0395	ABC-type sugar transport system, permease component
CP972_RS08575	COG1063	alcohol dehydrogenase
CP972_RS08615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP972_RS08625	COG1595	DNA-templated transcription, initiation
CP972_RS08630	COG2171	N-acyltransferase activity
CP972_RS08635	COG3226	Transcriptional regulator
CP972_RS08645	COG2151	metal-sulfur cluster biosynthetic enzyme
CP972_RS08650	COG0822	iron-sulfur transferase activity
CP972_RS08655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP972_RS08660	COG0396	ATPase activity
CP972_RS08670	COG0719	Fe-S assembly protein
CP972_RS08685	COG1131	(ABC) transporter
CP972_RS08695	COG1612	heme a metabolic process
CP972_RS08705	COG0109	protoheme IX farnesyltransferase activity
CP972_RS08715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP972_RS08730	COG0363	glucosamine-6-phosphate deaminase activity
CP972_RS08735	COG0395	ABC-type sugar transport system, permease component
CP972_RS08740	COG1175	transmembrane transport
CP972_RS08745	COG1653	transport
CP972_RS08750	COG0366	Alpha amylase catalytic
CP972_RS08760	COG1695	Transcriptional regulator
CP972_RS08765	COG1136	(ABC) transporter
CP972_RS08780	COG0166	Belongs to the GPI family
CP972_RS08790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP972_RS08795	COG0149	triose-phosphate isomerase activity
CP972_RS08800	COG0126	phosphoglycerate kinase activity
CP972_RS08805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP972_RS08810	COG1481	regulation of sporulation
CP972_RS08820	COG1660	Displays ATPase and GTPase activities
CP972_RS08825	COG0322	excinuclease ABC activity
CP972_RS08840	COG0723	plastoquinol--plastocyanin reductase activity
CP972_RS08850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP972_RS08855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP972_RS08875	COG0738	Major facilitator superfamily
CP972_RS08880	COG3226	Transcriptional regulator
CP972_RS08885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP972_RS08890	COG0387	Pfam Sodium calcium exchanger
CP972_RS08910	COG0556	nucleotide-excision repair
CP972_RS08920	COG0584	glycerophosphoryl diester phosphodiesterase
CP972_RS08925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP972_RS08935	COG2313	pseudouridylate synthase activity
CP972_RS09045	COG2267	carboxylic ester hydrolase activity
CP972_RS09065	COG2226	methyltransferase
CP972_RS09080	COG0237	dephospho-CoA kinase activity
CP972_RS09105	COG1643	Atp-dependent helicase
CP972_RS09135	COG2050	protein possibly involved in aromatic compounds catabolism
CP972_RS09200	COG0287	Prephenate dehydrogenase
CP972_RS09200	COG1605	Chorismate mutase
CP972_RS09210	COG2304	oxidoreductase activity
CP972_RS09215	COG0705	Rhomboid family
CP972_RS09230	COG0070	glutamate synthase
CP972_RS09230	COG0069	glutamate synthase activity
CP972_RS09230	COG0067	glutamate synthase
CP972_RS09240	COG1397	ADP-ribosylglycohydrolase
CP972_RS09260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP972_RS09270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP972_RS09280	COG0159	tryptophan synthase activity
CP972_RS09285	COG0133	tryptophan synthase activity
CP972_RS09295	COG0134	indole-3-glycerol-phosphate synthase activity
CP972_RS09320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP972_RS09335	COG0107	imidazoleglycerol-phosphate synthase activity
CP972_RS09340	COG0251	oxidation-reduction process
CP972_RS09345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP972_RS09350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP972_RS09355	COG0131	Imidazoleglycerol-phosphate dehydratase
CP972_RS09360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP972_RS09365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP972_RS09405	COG1432	Conserved Protein
CP972_RS09410	COG0587	DNA-directed DNA polymerase activity
CP972_RS09465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP972_RS09480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP972_RS09485	COG3599	regulation of cell shape
CP972_RS09495	COG1799	cell septum assembly
CP972_RS09505	COG1496	oxidoreductase activity
CP972_RS09510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CP972_RS09515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP972_RS09520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP972_RS09530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP972_RS09535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP972_RS09545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP972_RS09550	COG0768	penicillin binding
CP972_RS09560	COG0275	rRNA processing
CP972_RS09570	COG0714	Associated with various cellular activities
CP972_RS09590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP972_RS09600	COG1309	transcriptional regulator
CP972_RS09620	COG0352	thiamine-phosphate diphosphorylase activity
CP972_RS09640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP972_RS09640	COG2022	thiamine diphosphate biosynthetic process
CP972_RS09650	COG2022	thiamine diphosphate biosynthetic process
CP972_RS09655	COG2815	serine threonine protein kinase
CP972_RS09655	COG0515	serine threonine protein kinase
CP972_RS09660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CP972_RS09665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP972_RS09670	COG2193	ferroxidase activity
CP972_RS09680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP972_RS09690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP972_RS09730	COG1940	carbohydrate kinase activity
CP972_RS09740	COG0003	Pfam Anion-transporting ATPase
CP972_RS09755	COG1022	Amp-dependent synthetase and ligase
CP972_RS09780	COG3103	Sh3 type 3 domain protein
CP972_RS09780	COG1388	LysM domain
CP972_RS09780	COG0791	NLP P60 protein
CP972_RS09810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP972_RS09815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP972_RS09820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP972_RS09825	COG0723	plastoquinol--plastocyanin reductase activity
CP972_RS09830	COG2010	Cytochrome c
CP972_RS09835	COG1845	cytochrome c oxidase, subunit III
CP972_RS09845	COG1376	ErfK ybiS ycfS ynhG family protein
CP972_RS09855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP972_RS09860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP972_RS09870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP972_RS09895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CP972_RS09900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP972_RS09905	COG2197	response regulator
CP972_RS09910	COG4585	Histidine kinase
CP972_RS09945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP972_RS09950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP972_RS09960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CP972_RS09970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP972_RS09975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP972_RS09980	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP972_RS09990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP972_RS10025	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CP972_RS10035	COG0321	lipoyl(octanoyl) transferase activity
CP972_RS10040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP972_RS10060	COG0174	glutamine synthetase
CP972_RS10105	COG0745	RESPONSE REGULATOR receiver
CP972_RS10115	COG4585	Histidine kinase
CP972_RS10120	COG2197	response regulator
CP972_RS10185	COG0366	Alpha amylase catalytic
CP972_RS10190	COG3833	ABC-type maltose transport systems, permease component
CP972_RS10195	COG1175	transmembrane transport
CP972_RS10205	COG1609	Transcriptional regulator
CP972_RS10215	COG4251	negative regulation of phosphorylation
CP972_RS10220	COG0784	Response regulator, receiver
CP972_RS10230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP972_RS10250	COG2175	clavaminate synthase activity
CP972_RS10255	COG0174	glutamine synthetase
CP972_RS10265	COG1959	2 iron, 2 sulfur cluster binding
CP972_RS10270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP972_RS10270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP972_RS10285	COG0477	Major facilitator Superfamily
CP972_RS10290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP972_RS10310	COG1994	Peptidase M50
CP972_RS10350	COG1846	Transcriptional regulator
CP972_RS10350	COG1940	carbohydrate kinase activity
CP972_RS10380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP972_RS10405	COG0702	epimerase
CP972_RS10470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP972_RS10475	COG1120	ATPase activity
CP972_RS10505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP972_RS10510	COG2814	Major facilitator Superfamily
CP972_RS10520	COG2259	Doxx family
CP972_RS10535	COG3409	Peptidoglycan-binding domain 1 protein
CP972_RS10555	COG2197	response regulator
CP972_RS10560	COG4585	Histidine kinase
CP972_RS10570	COG1136	(ABC) transporter
CP972_RS10570	COG0577	efflux transmembrane transporter activity
CP972_RS10590	COG0515	serine threonine protein kinase
CP972_RS10635	COG3022	response to hydroperoxide
CP972_RS10640	COG0800	Aldolase
CP972_RS10655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CP972_RS10665	COG2030	dehydratase
CP972_RS10670	COG2197	response regulator
CP972_RS10680	COG0477	Major facilitator Superfamily
CP972_RS10690	COG2247	cell wall binding repeat
CP972_RS10690	COG0860	N-Acetylmuramoyl-L-alanine amidase
CP972_RS10715	COG0438	transferase activity, transferring glycosyl groups
CP972_RS10720	COG1309	transcriptional regulator
CP972_RS10725	COG1657	PFAM Prenyltransferase squalene oxidase
CP972_RS10740	COG3845	ABC transporter
CP972_RS10750	COG0741	lytic transglycosylase activity
CP972_RS10845	COG0586	Pfam SNARE associated Golgi protein
CP972_RS10855	COG1358	cellular component organization or biogenesis
CP972_RS10905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP972_RS10930	COG0667	Aldo Keto reductase
CP972_RS10935	COG0789	Transcriptional regulator
CP972_RS10985	COG0535	radical SAM domain protein
CP972_RS11035	COG2271	Major facilitator Superfamily
CP972_RS11040	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS11050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP972_RS11075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP972_RS11080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP972_RS11085	COG3629	intracellular signal transduction
CP972_RS11105	COG2050	protein possibly involved in aromatic compounds catabolism
CP972_RS11145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP972_RS11155	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS11165	COG2072	flavoprotein involved in K transport
CP972_RS11180	COG1741	Belongs to the pirin family
CP972_RS11195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP972_RS11200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP972_RS11205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP972_RS11235	COG2130	NADP-dependent
CP972_RS11275	COG4214	carbohydrate transport
CP972_RS11285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP972_RS11290	COG3940	Belongs to the glycosyl hydrolase 43 family
CP972_RS11295	COG3507	Belongs to the glycosyl hydrolase 43 family
CP972_RS11365	COG1302	Protein conserved in bacteria
CP972_RS11400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CP972_RS11425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CP972_RS11475	COG0395	ABC-type sugar transport system, permease component
CP972_RS11480	COG1175	transmembrane transport
CP972_RS11510	COG3386	PFAM SMP-30 Gluconolaconase
CP972_RS11515	COG1414	Transcriptional regulator
CP972_RS11540	COG4981	capsule polysaccharide biosynthetic process
CP972_RS11575	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS11580	COG0825	malonyl-CoA metabolic process
CP972_RS11580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CP972_RS11585	COG1077	Cell shape determining protein MreB Mrl
CP972_RS11625	COG1070	Carbohydrate kinase
CP972_RS11640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP972_RS11645	COG0358	DNA primase activity
CP972_RS11655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP972_RS11665	COG2949	membrane
CP972_RS11685	COG0243	molybdopterin cofactor binding
CP972_RS11700	COG1733	regulation of RNA biosynthetic process
CP972_RS11715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP972_RS11720	COG2146	nitrite reductase [NAD(P)H] activity
CP972_RS11720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP972_RS11760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP972_RS11760	COG0574	Belongs to the PEP-utilizing enzyme family
CP972_RS11810	COG0423	glycine-tRNA ligase activity
CP972_RS11815	COG3443	Belongs to the bacterial solute-binding protein 9 family
CP972_RS11815	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP972_RS11820	COG1121	(ABC) transporter
CP972_RS11825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP972_RS11835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP972_RS11840	COG1381	Involved in DNA repair and RecF pathway recombination
CP972_RS11910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP972_RS11935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP972_RS11950	COG2315	Protein conserved in bacteria
CP972_RS11960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP972_RS11975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP972_RS11980	COG1234	tRNA 3'-trailer cleavage
CP972_RS11985	COG0537	adenosine 5'-monophosphoramidase activity
CP972_RS11990	COG4946	Tricorn protease homolog
CP972_RS11990	COG0793	Belongs to the peptidase S41A family
CP972_RS12010	COG0484	heat shock protein binding
CP972_RS12015	COG1420	regulation of RNA biosynthetic process
CP972_RS12055	COG1131	(ABC) transporter
CP972_RS12110	COG1022	Amp-dependent synthetase and ligase
CP972_RS12120	COG0481	GTPase activity
CP972_RS12130	COG0268	Binds directly to 16S ribosomal RNA
CP972_RS12150	COG1234	tRNA 3'-trailer cleavage
CP972_RS12155	COG1596	polysaccharide export
CP972_RS12155	COG1555	photosystem II stabilization
CP972_RS12160	COG1307	EDD domain protein, DegV family
CP972_RS12170	COG0495	leucyl-tRNA aminoacylation
CP972_RS12180	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP972_RS12200	COG0588	phosphoglycerate mutase activity
CP972_RS12205	COG0799	negative regulation of ribosome biogenesis
CP972_RS12215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP972_RS12220	COG0501	Belongs to the peptidase M48B family
CP972_RS12235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP972_RS12245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP972_RS12260	COG1215	transferase activity, transferring glycosyl groups
CP972_RS12275	COG3540	Alkaline phosphatase
CP972_RS12280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP972_RS12285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP972_RS12290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP972_RS12300	COG0753	catalase activity
CP972_RS12310	COG1530	ribonuclease E activity
CP972_RS12340	COG0772	Belongs to the SEDS family
CP972_RS12345	COG0768	penicillin binding
CP972_RS12360	COG1077	Cell shape determining protein MreB Mrl
CP972_RS12370	COG0285	dihydrofolate synthase activity
CP972_RS12375	COG0525	valine-tRNA ligase activity
CP972_RS12385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP972_RS12390	COG0740	serine-type endopeptidase activity
CP972_RS12395	COG0740	serine-type endopeptidase activity
CP972_RS12400	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP972_RS12420	COG3594	Acyltransferase
CP972_RS12455	COG1113	amino acid transport
CP972_RS12460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CP972_RS12470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP972_RS12510	COG1595	DNA-templated transcription, initiation
CP972_RS12590	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS12595	COG1309	transcriptional regulator
CP972_RS12695	COG1136	(ABC) transporter
CP972_RS12695	COG0577	efflux transmembrane transporter activity
CP972_RS12715	COG0668	transmembrane transport
CP972_RS12725	COG1486	melibiose metabolic process
CP972_RS12740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP972_RS12775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP972_RS12815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP972_RS12835	COG2267	carboxylic ester hydrolase activity
CP972_RS12860	COG2304	oxidoreductase activity
CP972_RS12885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP972_RS12895	COG0728	peptidoglycan biosynthetic process
CP972_RS12905	COG0438	transferase activity, transferring glycosyl groups
CP972_RS12925	COG0492	ferredoxin-NADP+ reductase activity
CP972_RS12950	COG1131	(ABC) transporter
CP972_RS12990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CP972_RS13015	COG1733	regulation of RNA biosynthetic process
CP972_RS13020	COG0667	Aldo Keto reductase
CP972_RS13035	COG1609	Transcriptional regulator
CP972_RS13040	COG1129	ABC transporter
CP972_RS13045	COG1879	ABC-type sugar transport system periplasmic component
CP972_RS13050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP972_RS13055	COG1869	D-ribose catabolic process
CP972_RS13070	COG0673	inositol 2-dehydrogenase activity
CP972_RS13100	COG1472	Belongs to the glycosyl hydrolase 3 family
CP972_RS13125	COG2356	endonuclease I
CP972_RS13130	COG0346	lactoylglutathione lyase activity
CP972_RS13140	COG3708	Transcriptional regulator
CP972_RS13140	COG2207	Transcriptional regulator
CP972_RS13170	COG0028	Belongs to the TPP enzyme family
CP972_RS13190	COG1946	Acyl-CoA thioesterase
CP972_RS13200	COG1309	transcriptional regulator
CP972_RS13205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP972_RS13220	COG1960	acyl-CoA dehydrogenase activity
CP972_RS13240	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP972_RS13265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP972_RS13270	COG0589	response to stress
CP972_RS13275	COG4977	sequence-specific DNA binding
CP972_RS13280	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CP972_RS13310	COG0395	ABC-type sugar transport system, permease component
CP972_RS13340	COG0745	RESPONSE REGULATOR receiver
CP972_RS13365	COG0406	alpha-ribazole phosphatase activity
CP972_RS13415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS13430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP972_RS13445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP972_RS13450	COG0765	amino acid transport
CP972_RS13455	COG0765	amino acid transport
CP972_RS13460	COG1126	abc transporter atp-binding protein
CP972_RS13475	COG3397	chitin binding
CP972_RS13530	COG1940	carbohydrate kinase activity
CP972_RS13540	COG0673	inositol 2-dehydrogenase activity
CP972_RS13545	COG4702	Belongs to the UPF0303 family
CP972_RS13550	COG0706	membrane insertase activity
CP972_RS13560	COG3250	beta-galactosidase activity
CP972_RS13575	COG0726	polysaccharide deacetylase
CP972_RS13635	COG0346	lactoylglutathione lyase activity
CP972_RS13685	COG1819	glycosyl
CP972_RS13760	COG2814	Major facilitator Superfamily
CP972_RS13765	COG2733	membrane
CP972_RS13795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP972_RS13800	COG2076	Multidrug Resistance protein
CP972_RS13830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP972_RS13840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP972_RS13845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP972_RS13850	COG1263	PTS System
CP972_RS13860	COG1263	PTS System
CP972_RS13865	COG1234	tRNA 3'-trailer cleavage
CP972_RS13890	COG1113	amino acid transport
CP972_RS13900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP972_RS13910	COG1335	isochorismatase
CP972_RS13945	COG0277	FAD linked oxidase domain protein
CP972_RS13955	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP972_RS13965	COG1174	glycine betaine transport
CP972_RS13970	COG0517	IMP dehydrogenase activity
CP972_RS13970	COG1125	glycine betaine transport
CP972_RS13975	COG1174	glycine betaine transport
CP972_RS13985	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP972_RS14025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP972_RS14040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP972_RS14045	COG0395	ABC-type sugar transport system, permease component
CP972_RS14050	COG1175	transmembrane transport
CP972_RS14065	COG1678	Uncharacterized ACR, COG1678
CP972_RS14075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP972_RS14080	COG0776	regulation of translation
CP972_RS14090	COG3973	AAA domain
CP972_RS14115	COG2223	nitrite transmembrane transporter activity
CP972_RS14145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP972_RS14180	COG1609	Transcriptional regulator
CP972_RS14195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP972_RS14200	COG0793	Belongs to the peptidase S41A family
CP972_RS14210	COG2884	Cell division ATP-binding protein ftsE
CP972_RS14225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP972_RS14230	COG0515	serine threonine protein kinase
CP972_RS14235	COG0515	serine threonine protein kinase
CP972_RS14240	COG1674	ftsk spoiiie
CP972_RS14250	COG1175	transmembrane transport
CP972_RS14255	COG0395	ABC-type sugar transport system, permease component
CP972_RS14260	COG1764	response to oxidative stress
CP972_RS14265	COG1846	Transcriptional regulator
CP972_RS14285	COG1134	teichoic acid transport
CP972_RS14290	COG2902	Dehydrogenase
CP972_RS14315	COG0653	protein targeting
CP972_RS14325	COG3214	Protein conserved in bacteria
CP972_RS14330	COG2197	response regulator
CP972_RS14335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP972_RS14345	COG0823	Involved in the tonB-independent uptake of proteins
CP972_RS14350	COG5000	phosphorelay sensor kinase activity
CP972_RS14350	COG5002	protein histidine kinase activity
CP972_RS14355	COG0745	RESPONSE REGULATOR receiver
CP972_RS14360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CP972_RS14380	COG0714	Associated with various cellular activities
CP972_RS14425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP972_RS14440	COG1482	cell wall glycoprotein biosynthetic process
CP972_RS14450	COG2835	tetraacyldisaccharide 4'-kinase activity
CP972_RS14455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP972_RS14460	COG1620	l-lactate permease
CP972_RS14500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP972_RS14505	COG0778	Nitroreductase
CP972_RS14505	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CP972_RS14535	COG1316	TRANSCRIPTIONal
CP972_RS14540	COG1316	TRANSCRIPTIONal
CP972_RS14555	COG1316	TRANSCRIPTIONal
CP972_RS14580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP972_RS14620	COG2205	protein histidine kinase activity
CP972_RS14625	COG0745	RESPONSE REGULATOR receiver
CP972_RS14630	COG3104	oligopeptide transport
CP972_RS14640	COG1366	Belongs to the anti-sigma-factor antagonist family
CP972_RS14645	COG1191	sigma factor activity
CP972_RS14655	COG1228	amidohydrolase
CP972_RS14700	COG2755	lipolytic protein G-D-S-L family
CP972_RS14705	COG0183	Belongs to the thiolase family
CP972_RS14760	COG0577	efflux transmembrane transporter activity
CP972_RS14760	COG1136	(ABC) transporter
CP972_RS14765	COG0577	efflux transmembrane transporter activity
CP972_RS14770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP972_RS14775	COG1252	NADH dehydrogenase
CP972_RS14805	COG0148	phosphopyruvate hydratase activity
CP972_RS14815	COG1652	LysM domain
CP972_RS14870	COG0577	efflux transmembrane transporter activity
CP972_RS14875	COG1136	(ABC) transporter
CP972_RS14905	COG4585	Histidine kinase
CP972_RS14915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP972_RS14920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP972_RS14925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP972_RS14930	COG0193	aminoacyl-tRNA hydrolase activity
CP972_RS14940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CP972_RS14950	COG1309	transcriptional regulator
CP972_RS14955	COG4106	trans-aconitate 2-methyltransferase activity
CP972_RS14960	COG1846	Transcriptional regulator
CP972_RS14965	COG2197	response regulator
CP972_RS14975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CP972_RS15015	COG0488	(ABC) transporter
CP972_RS15025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP972_RS15030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP972_RS15035	COG0084	hydrolase, TatD family'
CP972_RS15080	COG0310	cobalt ion transport
CP972_RS15090	COG1122	ATPase activity
CP972_RS15095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP972_RS15105	COG2409	Drug exporters of the RND superfamily
CP972_RS15115	COG0793	Belongs to the peptidase S41A family
CP972_RS15115	COG4946	Tricorn protease homolog
CP972_RS15130	COG2267	carboxylic ester hydrolase activity
CP972_RS15150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP972_RS15155	COG0708	Exodeoxyribonuclease III
CP972_RS15185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP972_RS15190	COG0315	cyclic pyranopterin monophosphate synthase activity
CP972_RS15190	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP972_RS15195	COG0315	cyclic pyranopterin monophosphate synthase activity
CP972_RS15205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP972_RS15210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP972_RS15235	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CP972_RS15245	COG1970	mechanosensitive ion channel activity
CP972_RS15275	COG1105	Belongs to the carbohydrate kinase PfkB family
CP972_RS15280	COG1349	DNA-binding transcription factor activity
CP972_RS15295	COG3384	dioxygenase
CP972_RS15300	COG1846	Transcriptional regulator
CP972_RS15320	COG0589	response to stress
CP972_RS15345	COG4974	Belongs to the 'phage' integrase family
CP972_RS15385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP972_RS15395	COG0717	Belongs to the dCTP deaminase family
CP972_RS15405	COG0297	glycogen (starch) synthase activity
CP972_RS15490	COG1487	ribonuclease activity
CP972_RS15565	COG0477	Major facilitator Superfamily
CP972_RS15600	COG1597	lipid kinase activity
CP972_RS15610	COG3594	Acyltransferase
CP972_RS15635	COG2124	cytochrome p450
CP972_RS15655	COG1278	Cold shock
CP972_RS15660	COG0513	Belongs to the DEAD box helicase family
CP972_RS15685	COG0386	Belongs to the glutathione peroxidase family
CP972_RS15710	COG1686	Belongs to the peptidase S11 family
CP972_RS15740	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP972_RS15760	COG0515	serine threonine protein kinase
CP972_RS15760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP972_RS15770	COG1309	transcriptional regulator
CP972_RS15780	COG0259	pyridoxamine-phosphate oxidase activity
CP972_RS15790	COG2271	Major facilitator Superfamily
CP972_RS15860	COG0596	Alpha beta hydrolase
CP972_RS15860	COG2945	thiolester hydrolase activity
CP972_RS15870	COG4821	SIS domain
CP972_RS15885	COG0259	pyridoxamine-phosphate oxidase activity
CP972_RS15900	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS15915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP972_RS15965	COG0247	lactate metabolic process
CP972_RS15965	COG0277	FAD linked oxidase domain protein
CP972_RS15990	COG2124	cytochrome p450
CP972_RS16000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP972_RS16035	COG0667	Aldo Keto reductase
CP972_RS16065	COG2252	PERMEase
CP972_RS16075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP972_RS16085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CP972_RS16085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP972_RS16100	COG2814	Major facilitator Superfamily
CP972_RS16110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP972_RS16115	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP972_RS16120	COG1278	Cold shock
CP972_RS16155	COG1061	Type III restriction enzyme res subunit
CP972_RS16180	COG3973	AAA domain
CP972_RS16230	COG1737	Transcriptional regulator
CP972_RS16235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CP972_RS16255	COG0459	protein refolding
CP972_RS16260	COG1278	Cold shock
CP972_RS16275	COG0463	Glycosyl transferase, family 2
CP972_RS16305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CP972_RS16335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP972_RS16375	COG4977	sequence-specific DNA binding
CP972_RS16400	COG2378	regulation of single-species biofilm formation
CP972_RS16405	COG3842	ATPase activity
CP972_RS16425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP972_RS16430	COG0215	cysteine-tRNA ligase activity
CP972_RS16435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP972_RS16440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP972_RS16445	COG1329	Transcriptional regulator
CP972_RS16465	COG5002	protein histidine kinase activity
CP972_RS16490	COG0588	phosphoglycerate mutase activity
CP972_RS16505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP972_RS16545	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP972_RS16625	COG0655	NAD(P)H dehydrogenase (quinone) activity
CP972_RS16640	COG1295	ribonuclease BN
CP972_RS16670	COG0438	transferase activity, transferring glycosyl groups
CP972_RS16710	COG0702	epimerase
CP972_RS16730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP972_RS16745	COG2188	Transcriptional regulator
CP972_RS16755	COG2188	Transcriptional regulator
CP972_RS16760	COG4552	Acetyltransferase involved in intracellular survival and related
CP972_RS16770	COG1490	D-aminoacyl-tRNA deacylase activity
CP972_RS16785	COG3485	protocatechuate 3,4-dioxygenase
CP972_RS16835	COG0745	RESPONSE REGULATOR receiver
CP972_RS16840	COG1609	Transcriptional regulator
CP972_RS16850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP972_RS16865	COG3866	Pectate lyase
CP972_RS16895	COG0737	Belongs to the 5'-nucleotidase family
CP972_RS16900	COG0456	acetyltransferase
CP972_RS16915	COG1131	(ABC) transporter
CP972_RS16930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CP972_RS16940	COG0406	alpha-ribazole phosphatase activity
CP972_RS16940	COG0494	nUDIX hydrolase
CP972_RS16960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP972_RS16965	COG0306	phosphate transporter
CP972_RS16975	COG1937	Protein conserved in bacteria
CP972_RS16990	COG0671	phosphoesterase, PA-phosphatase related
CP972_RS16995	COG0739	heme binding
CP972_RS16995	COG1196	nuclear chromosome segregation
CP972_RS16995	COG0741	lytic transglycosylase activity
CP972_RS17050	COG1131	(ABC) transporter
CP972_RS17060	COG4585	Histidine kinase
CP972_RS17065	COG2197	response regulator
CP972_RS17105	COG1252	NADH dehydrogenase
CP972_RS17130	COG0579	oxidoreductase
CP972_RS17135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP972_RS17145	COG0739	heme binding
CP972_RS17145	COG1196	nuclear chromosome segregation
CP972_RS17145	COG0741	lytic transglycosylase activity
CP972_RS17155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP972_RS17155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP972_RS17160	COG0475	glutathione-regulated potassium exporter activity
CP972_RS17165	COG2197	response regulator
CP972_RS17170	COG3851	Histidine kinase
CP972_RS17190	COG1309	transcriptional regulator
CP972_RS17205	COG0513	Belongs to the DEAD box helicase family
CP972_RS17240	COG1643	Atp-dependent helicase
CP972_RS17275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP972_RS17305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP972_RS17310	COG0047	phosphoribosylformylglycinamidine synthase activity
CP972_RS17315	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP972_RS17360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP972_RS17375	COG0151	Belongs to the GarS family
CP972_RS17415	COG1278	Cold shock
CP972_RS17420	COG0513	Belongs to the DEAD box helicase family
CP972_RS17425	COG1073	alpha beta
CP972_RS17435	COG0659	secondary active sulfate transmembrane transporter activity
CP972_RS17445	COG0789	Transcriptional regulator
CP972_RS17455	COG1278	Cold shock
CP972_RS17470	COG0366	Alpha amylase catalytic
CP972_RS17475	COG1957	nucleoside hydrolase
CP972_RS17495	COG1653	transport
CP972_RS17545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP972_RS17575	COG0326	Molecular chaperone. Has ATPase activity
CP972_RS17580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP972_RS17595	COG1741	Belongs to the pirin family
CP972_RS17605	COG1960	acyl-CoA dehydrogenase activity
CP972_RS17610	COG1362	aminopeptidase activity
CP972_RS17700	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP972_RS17705	COG0022	dehydrogenase e1 component
CP972_RS17720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CP972_RS17725	COG0515	serine threonine protein kinase
CP972_RS17730	COG0515	serine threonine protein kinase
CP972_RS17745	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS17745	COG0604	alcohol dehydrogenase
CP972_RS17745	COG3321	synthase
CP972_RS17780	COG1522	sequence-specific DNA binding
CP972_RS17785	COG1309	transcriptional regulator
CP972_RS17790	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP972_RS17820	COG3396	Phenylacetate-CoA oxygenase
CP972_RS17825	COG3460	Phenylacetate-CoA oxygenase
CP972_RS17830	COG3396	Phenylacetate-CoA oxygenase
CP972_RS17835	COG2151	metal-sulfur cluster biosynthetic enzyme
CP972_RS17840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP972_RS17865	COG1716	ATPase activity
CP972_RS17870	COG1716	ATPase activity
CP972_RS17885	COG0768	penicillin binding
CP972_RS17895	COG0515	serine threonine protein kinase
CP972_RS17905	COG3764	Sortase (surface protein transpeptidase)
CP972_RS17910	COG3764	Sortase (surface protein transpeptidase)
CP972_RS17935	COG0705	Rhomboid family
CP972_RS17960	COG0515	serine threonine protein kinase
CP972_RS17990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP972_RS17995	COG0187	DNA topoisomerase II activity
CP972_RS18000	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CP972_RS18005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP972_RS18010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP972_RS18015	COG0592	DNA-directed DNA polymerase activity
CP972_RS18025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CP972_RS18030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CP972_RS18035	COG0594	ribonuclease P activity
CP972_RS18040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CP972_RS18045	COG0706	membrane insertase activity
CP972_RS18055	COG0357	Ribosomal RNA small subunit methyltransferase G
CP972_RS18060	COG1192	Involved in chromosome partitioning
CP972_RS18075	COG3118	belongs to the thioredoxin family
CP972_RS18080	COG0492	ferredoxin-NADP+ reductase activity
CP972_RS18090	COG1595	DNA-templated transcription, initiation
CP972_RS18110	COG0617	tRNA 3'-terminal CCA addition
CP972_RS18135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP972_RS18160	COG0360	Binds together with S18 to 16S ribosomal RNA
CP972_RS18165	COG0629	single-stranded DNA binding
CP972_RS18170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP972_RS18175	COG0359	binds to the 23S rRNA
CP972_RS18185	COG0305	Participates in initiation and elongation during chromosome replication
CP972_RS18205	COG2814	Major facilitator Superfamily
CP972_RS18230	COG0626	cystathionine gamma-synthase activity
CP972_RS18235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP972_RS18240	COG1950	PFAM Membrane protein of
CP972_RS18245	COG0662	Cupin 2, conserved barrel domain protein
CP972_RS18270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP972_RS18290	COG1609	Transcriptional regulator
CP972_RS18295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP972_RS18300	COG1271	oxidase subunit
CP972_RS18305	COG1294	oxidase, subunit
CP972_RS18310	COG4988	ABC transporter
CP972_RS18315	COG0739	heme binding
CP972_RS18320	COG0561	phosphatase activity
CP972_RS18340	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CP972_RS18375	COG0561	phosphatase activity
CP972_RS18380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP972_RS18385	COG0077	Prephenate dehydratase
CP972_RS18390	COG2837	iron assimilation
CP972_RS18405	COG1999	signal sequence binding
CP972_RS18440	COG0653	protein targeting
CP972_RS18455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP972_RS18490	COG1595	DNA-templated transcription, initiation
CP972_RS18495	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS18500	COG0784	Response regulator, receiver
CP972_RS18515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP972_RS18535	COG0745	RESPONSE REGULATOR receiver
CP972_RS18545	COG3467	pyridoxamine 5'-phosphate
CP972_RS18565	COG1191	sigma factor activity
CP972_RS18570	COG1191	sigma factor activity
CP972_RS18605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CP972_RS18650	COG1116	anion transmembrane transporter activity
CP972_RS18665	COG2197	response regulator
CP972_RS18675	COG1733	regulation of RNA biosynthetic process
CP972_RS18680	COG0251	oxidation-reduction process
CP972_RS18690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP972_RS18700	COG0583	DNA-binding transcription factor activity
CP972_RS18710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP972_RS18735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP972_RS18795	COG0384	phenazine biosynthesis protein PhzF
CP972_RS18805	COG2326	polyphosphate kinase activity
CP972_RS18815	COG0477	Major facilitator Superfamily
CP972_RS18830	COG4585	Histidine kinase
CP972_RS18840	COG0701	Predicted permease
CP972_RS18915	COG0745	RESPONSE REGULATOR receiver
CP972_RS18920	COG2205	protein histidine kinase activity
CP972_RS18955	COG2188	Transcriptional regulator
CP972_RS18975	COG0717	Belongs to the dCTP deaminase family
CP972_RS18980	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CP972_RS19075	COG0464	growth
CP972_RS19095	COG2181	nitrate reductase activity
CP972_RS19095	COG0247	lactate metabolic process
CP972_RS19100	COG0443	Heat shock 70 kDa protein
CP972_RS19105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP972_RS19110	COG0484	heat shock protein binding
CP972_RS19115	COG0789	Transcriptional regulator
CP972_RS19120	COG4213	ABC transporter substrate-binding protein
CP972_RS19145	COG0542	response to heat
CP972_RS19180	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP972_RS19195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP972_RS19200	COG0191	fructose-bisphosphate aldolase activity
CP972_RS19220	COG3386	PFAM SMP-30 Gluconolaconase
CP972_RS19225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CP972_RS19230	COG2814	Major facilitator Superfamily
CP972_RS19245	COG3844	kynureninase activity
CP972_RS19265	COG4585	Histidine kinase
CP972_RS19270	COG2197	response regulator
CP972_RS19275	COG4585	Histidine kinase
CP972_RS19280	COG2197	response regulator
CP972_RS19295	COG3559	Exporter of polyketide antibiotics
CP972_RS19320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP972_RS19335	COG1802	Transcriptional regulator
CP972_RS19340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP972_RS19345	COG1846	Transcriptional regulator
CP972_RS19360	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP972_RS19365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP972_RS19385	COG1595	DNA-templated transcription, initiation
CP972_RS19410	COG0701	Predicted permease
CP972_RS19540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP972_RS19605	COG1609	Transcriptional regulator
CP972_RS19645	COG1408	metallophosphoesterase
CP972_RS19670	COG0003	Pfam Anion-transporting ATPase
CP972_RS19725	COG2267	carboxylic ester hydrolase activity
CP972_RS19735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP972_RS19740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP972_RS19745	COG0659	secondary active sulfate transmembrane transporter activity
CP972_RS19810	COG1366	Belongs to the anti-sigma-factor antagonist family
CP972_RS19820	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP972_RS19830	COG2890	protein-(glutamine-N5) methyltransferase activity
CP972_RS19840	COG1754	DNA topoisomerase type I activity
CP972_RS19840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP972_RS19845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP972_RS19865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP972_RS19865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP972_RS19910	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS19915	COG2318	DinB family
CP972_RS19935	COG0076	glutamate decarboxylase activity
CP972_RS19945	COG0789	Transcriptional regulator
CP972_RS19950	COG0393	Putative heavy-metal-binding
CP972_RS19955	COG0586	Pfam SNARE associated Golgi protein
CP972_RS19965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP972_RS19970	COG2027	D-alanyl-D-alanine carboxypeptidase
CP972_RS19980	COG0037	tRNA processing
CP972_RS19985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CP972_RS19995	COG0302	gtp cyclohydrolase
CP972_RS20010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CP972_RS20040	COG0649	NAD binding
CP972_RS20055	COG2197	response regulator
CP972_RS20060	COG1660	Displays ATPase and GTPase activities
CP972_RS20080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP972_RS20085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP972_RS20095	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP972_RS20115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CP972_RS20145	COG0739	heme binding
CP972_RS20150	COG2205	protein histidine kinase activity
CP972_RS20155	COG0745	RESPONSE REGULATOR receiver
CP972_RS20165	COG1595	DNA-templated transcription, initiation
CP972_RS20170	COG1194	a g-specific adenine glycosylase
CP972_RS20180	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CP972_RS20200	COG0248	Ppx GppA phosphatase
CP972_RS20205	COG1082	Xylose isomerase domain protein TIM barrel
CP972_RS20210	COG1309	transcriptional regulator
CP972_RS20215	COG0129	dihydroxy-acid dehydratase activity
CP972_RS20220	COG0515	serine threonine protein kinase
CP972_RS20220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP972_RS20225	COG4991	sh3 domain protein
CP972_RS20235	COG0842	Transport permease protein
CP972_RS20235	COG1129	ABC transporter
CP972_RS20245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP972_RS20255	COG0180	Tryptophanyl-tRNA synthetase
CP972_RS20280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP972_RS20290	COG0123	including yeast histone deacetylase and acetoin utilization protein
CP972_RS20340	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CP972_RS20345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CP972_RS20350	COG0181	hydroxymethylbilane synthase activity
CP972_RS20355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP972_RS20355	COG1648	precorrin-2 dehydrogenase activity
CP972_RS20400	COG3973	AAA domain
CP972_RS20410	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS20430	COG0113	porphobilinogen synthase activity
CP972_RS20450	COG0018	arginyl-trna synthetase
CP972_RS20455	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP972_RS20475	COG1690	Belongs to the RtcB family
CP972_RS20485	COG1742	UPF0060 membrane protein
CP972_RS20490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS20505	COG2205	protein histidine kinase activity
CP972_RS20510	COG2340	Cysteine-rich secretory protein family
CP972_RS20525	COG1937	Protein conserved in bacteria
CP972_RS20530	COG0730	response to heat
CP972_RS20555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP972_RS20560	COG0406	alpha-ribazole phosphatase activity
CP972_RS20570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP972_RS20575	COG0785	Cytochrome C biogenesis protein
CP972_RS20580	COG1333	cytochrome c biogenesis protein
CP972_RS20585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP972_RS20590	COG0789	Transcriptional regulator
CP972_RS20600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CP972_RS20610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP972_RS20620	COG0163	prenyltransferase activity
CP972_RS20630	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP972_RS20645	COG1309	transcriptional regulator
CP972_RS20660	COG0183	Belongs to the thiolase family
CP972_RS20675	COG1278	Cold shock
CP972_RS20680	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP972_RS20690	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP972_RS20700	COG2226	methyltransferase
CP972_RS20720	COG3103	Sh3 type 3 domain protein
CP972_RS20720	COG0791	NLP P60 protein
CP972_RS20720	COG1388	LysM domain
CP972_RS20730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP972_RS20735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP972_RS20740	COG0649	NAD binding
CP972_RS20750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP972_RS20755	COG1034	ATP synthesis coupled electron transport
CP972_RS20760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP972_RS20765	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP972_RS20770	COG0839	Belongs to the complex I subunit 6 family
CP972_RS20775	COG0713	ATP synthesis coupled electron transport
CP972_RS20780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP972_RS20790	COG1007	ATP synthesis coupled electron transport
CP972_RS20795	COG0514	ATP-dependent DNA helicase (RecQ)
CP972_RS20855	COG0561	phosphatase activity
CP972_RS20860	COG3953	SLT domain
CP972_RS20860	COG5280	Phage tail tape measure protein TP901
CP972_RS20865	COG0142	geranyltranstransferase activity
CP972_RS20880	COG0655	NAD(P)H dehydrogenase (quinone) activity
CP972_RS20885	COG0154	amidase activity
CP972_RS20905	COG0702	epimerase
CP972_RS20910	COG1733	regulation of RNA biosynthetic process
CP972_RS20915	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP972_RS20940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP972_RS20945	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP972_RS20950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP972_RS20955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP972_RS20960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP972_RS20970	COG0713	ATP synthesis coupled electron transport
CP972_RS20975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP972_RS20985	COG1007	ATP synthesis coupled electron transport
CP972_RS20990	COG0501	Belongs to the peptidase M48B family
CP972_RS20995	COG3304	Inner membrane component domain
CP972_RS21010	COG1666	GTP binding
CP972_RS21140	COG0702	epimerase
CP972_RS21160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP972_RS21165	COG2030	dehydratase
CP972_RS21190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP972_RS21195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP972_RS21200	COG0436	Aminotransferase
CP972_RS21215	COG0250	Participates in transcription elongation, termination and antitermination
CP972_RS21220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP972_RS21225	COG0081	regulation of translation
CP972_RS21235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CP972_RS21240	COG0222	ribosome binding
CP972_RS21250	COG0085	RNA polymerase activity
CP972_RS21255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP972_RS21265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP972_RS21270	COG0049	tRNA binding
CP972_RS21275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP972_RS21280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP972_RS21285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CP972_RS21300	COG2197	response regulator
CP972_RS21305	COG4585	Histidine kinase
CP972_RS21310	COG0051	transcription antitermination factor activity, RNA binding
CP972_RS21315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP972_RS21320	COG0088	Forms part of the polypeptide exit tunnel
CP972_RS21325	COG0089	rRNA binding
CP972_RS21330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP972_RS21335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP972_RS21340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP972_RS21345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP972_RS21350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP972_RS21355	COG0255	Belongs to the universal ribosomal protein uL29 family
CP972_RS21360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP972_RS21365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP972_RS21370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP972_RS21375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP972_RS21380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP972_RS21390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP972_RS21395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP972_RS21400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP972_RS21405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP972_RS21410	COG1841	ribosomal large subunit assembly
CP972_RS21415	COG0200	Binds to the 23S rRNA
CP972_RS21420	COG0201	protein transport
CP972_RS21425	COG0563	adenylate kinase activity
CP972_RS21435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP972_RS21440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP972_RS21445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP972_RS21450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP972_RS21455	COG0202	RNA polymerase activity
CP972_RS21460	COG0203	ribosomal protein L17
CP972_RS21465	COG0101	tRNA pseudouridine synthase activity
CP972_RS21475	COG2843	Capsule synthesis protein
CP972_RS21505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP972_RS21510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP972_RS21515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP972_RS21520	COG1072	(Pantothenic acid kinase))
CP972_RS21530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP972_RS21535	COG0736	holo-[acyl-carrier-protein] synthase activity
CP972_RS21550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP972_RS21560	COG0802	atpase or kinase
CP972_RS21585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP972_RS21595	COG1609	Transcriptional regulator
CP972_RS21605	COG0726	polysaccharide deacetylase
CP972_RS21610	COG0726	polysaccharide deacetylase
CP972_RS21615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP972_RS21620	COG0459	protein refolding
CP972_RS21685	COG4221	oxidoreductase activity
CP972_RS21690	COG2132	Multicopper oxidase
CP972_RS21700	COG0583	DNA-binding transcription factor activity
CP972_RS21715	COG1595	DNA-templated transcription, initiation
CP972_RS21725	COG0516	GMP reductase activity
CP972_RS21740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP972_RS21750	COG0515	serine threonine protein kinase
CP972_RS21750	COG2815	serine threonine protein kinase
CP972_RS21755	COG0515	serine threonine protein kinase
CP972_RS21760	COG0515	serine threonine protein kinase
CP972_RS21760	COG2815	serine threonine protein kinase
CP972_RS21765	COG0515	serine threonine protein kinase
CP972_RS21770	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS21795	COG0519	Catalyzes the synthesis of GMP from XMP
CP972_RS21795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP972_RS21835	COG2197	response regulator
CP972_RS21865	COG0739	heme binding
CP972_RS21875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS21875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS21890	COG0714	Associated with various cellular activities
CP972_RS21895	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CP972_RS21900	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP972_RS21905	COG0045	succinate-CoA ligase (ADP-forming) activity
CP972_RS21935	COG0138	bifunctional purine biosynthesis protein purh
CP972_RS21945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP972_RS21960	COG0039	L-malate dehydrogenase activity
CP972_RS21970	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS21985	COG4176	ABC-type proline glycine betaine transport system permease component
CP972_RS21995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP972_RS22000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP972_RS22010	COG0754	glutathionylspermidine amidase activity
CP972_RS22015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP972_RS22020	COG0180	Tryptophanyl-tRNA synthetase
CP972_RS22030	COG1295	ribonuclease BN
CP972_RS22035	COG1686	Belongs to the peptidase S11 family
CP972_RS22040	COG1408	metallophosphoesterase
CP972_RS22045	COG1309	transcriptional regulator
CP972_RS22075	COG1053	succinate dehydrogenase
CP972_RS22085	COG2009	succinate dehydrogenase
CP972_RS22095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP972_RS22120	COG1595	DNA-templated transcription, initiation
CP972_RS22130	COG1595	DNA-templated transcription, initiation
CP972_RS22145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS22145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS22170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP972_RS22190	COG1216	Glycosyl transferase, family 2
CP972_RS22205	COG2089	acid synthase
CP972_RS22215	COG2771	luxR family
CP972_RS22230	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP972_RS22230	COG1473	amidohydrolase
CP972_RS22235	COG1744	ABC transporter substrate-binding protein PnrA-like
CP972_RS22240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP972_RS22245	COG1744	ABC transporter substrate-binding protein PnrA-like
CP972_RS22250	COG3845	ABC transporter
CP972_RS22260	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP972_RS22295	COG2814	Major facilitator Superfamily
CP972_RS22300	COG0583	DNA-binding transcription factor activity
CP972_RS22310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP972_RS22335	COG2205	protein histidine kinase activity
CP972_RS22340	COG0745	RESPONSE REGULATOR receiver
CP972_RS22345	COG1595	DNA-templated transcription, initiation
CP972_RS22360	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS22365	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS22370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CP972_RS22380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP972_RS22405	COG4770	biotin carboxylase activity
CP972_RS22410	COG0424	maF-like protein
CP972_RS22425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP972_RS22435	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP972_RS22445	COG1024	Enoyl-CoA hydratase
CP972_RS22455	COG2986	histidine ammonia-lyase
CP972_RS22480	COG1136	(ABC) transporter
CP972_RS22490	COG0714	Associated with various cellular activities
CP972_RS22495	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP972_RS22510	COG1404	Belongs to the peptidase S8 family
CP972_RS22530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP972_RS22545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP972_RS22555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP972_RS22570	COG1331	Highly conserved protein containing a thioredoxin domain
CP972_RS22585	COG1215	transferase activity, transferring glycosyl groups
CP972_RS22605	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CP972_RS22620	COG0436	Aminotransferase
CP972_RS22625	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP972_RS22640	COG1414	Transcriptional regulator
CP972_RS22645	COG0251	oxidation-reduction process
CP972_RS22650	COG2610	gluconate transmembrane transporter activity
CP972_RS22680	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS22720	COG2894	cell division
CP972_RS22755	COG2197	response regulator
CP972_RS22825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP972_RS22835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CP972_RS22850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP972_RS22860	COG1136	(ABC) transporter
CP972_RS22880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP972_RS22895	COG0114	fumarate hydratase activity
CP972_RS22905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CP972_RS22905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CP972_RS22935	COG0778	Nitroreductase
CP972_RS22945	COG1722	exodeoxyribonuclease VII activity
CP972_RS22950	COG1570	exodeoxyribonuclease VII activity
CP972_RS22955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP972_RS22970	COG0012	GTP binding
CP972_RS23005	COG2161	toxin-antitoxin pair type II binding
CP972_RS23010	COG4115	mRNA cleavage
CP972_RS23020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP972_RS23030	COG2130	NADP-dependent
CP972_RS23045	COG0604	alcohol dehydrogenase
CP972_RS23045	COG3321	synthase
CP972_RS23085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP972_RS23095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP972_RS23150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP972_RS23155	COG1053	succinate dehydrogenase
CP972_RS23175	COG1217	gtp-binding protein TYPA
CP972_RS23180	COG0747	negative chemotaxis
CP972_RS23185	COG0601	transmembrane transport
CP972_RS23190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP972_RS23195	COG0444	Belongs to the ABC transporter superfamily
CP972_RS23200	COG4608	Belongs to the ABC transporter superfamily
CP972_RS23210	COG0601	transmembrane transport
CP972_RS23215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP972_RS23220	COG0444	Belongs to the ABC transporter superfamily
CP972_RS23225	COG4608	Belongs to the ABC transporter superfamily
CP972_RS23230	COG0488	(ABC) transporter
CP972_RS23245	COG0154	amidase activity
CP972_RS23280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CP972_RS23320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP972_RS23350	COG0477	Major facilitator Superfamily
CP972_RS23390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP972_RS23400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP972_RS23410	COG0519	Catalyzes the synthesis of GMP from XMP
CP972_RS23415	COG1024	Enoyl-CoA hydratase
CP972_RS23430	COG1595	DNA-templated transcription, initiation
CP972_RS23440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP972_RS23445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP972_RS23480	COG0598	Magnesium transport protein CorA
CP972_RS23500	COG2095	MarC family integral membrane protein
CP972_RS23510	COG1432	Conserved Protein
CP972_RS23555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP972_RS23555	COG0596	Alpha beta hydrolase
CP972_RS23610	COG0210	DNA helicase
CP972_RS23705	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP972_RS23715	COG1615	UPF0182 protein
CP972_RS23745	COG0483	inositol monophosphate 1-phosphatase activity
CP972_RS23765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP972_RS23775	COG2135	peptidase activity
CP972_RS23785	COG1595	DNA-templated transcription, initiation
CP972_RS23790	COG5662	AntiSigma factor
CP972_RS23795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CP972_RS23795	COG2199	diguanylate cyclase activity
CP972_RS23810	COG0242	peptide deformylase activity
CP972_RS23820	COG2124	cytochrome p450
CP972_RS23840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP972_RS23840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP972_RS23855	COG2188	Transcriptional regulator
CP972_RS23860	COG0363	glucosamine-6-phosphate deaminase activity
CP972_RS23875	COG1597	lipid kinase activity
CP972_RS23895	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CP972_RS23910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP972_RS23915	COG0142	geranyltranstransferase activity
CP972_RS23920	COG0456	acetyltransferase
CP972_RS23995	COG4106	trans-aconitate 2-methyltransferase activity
CP972_RS24000	COG1126	abc transporter atp-binding protein
CP972_RS24025	COG0281	malic enzyme
CP972_RS24065	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP972_RS24065	COG0567	Dehydrogenase, E1 component
CP972_RS24070	COG2205	protein histidine kinase activity
CP972_RS24075	COG0745	RESPONSE REGULATOR receiver
CP972_RS24085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CP972_RS24155	COG0768	penicillin binding
CP972_RS24190	COG1595	DNA-templated transcription, initiation
CP972_RS24205	COG0702	epimerase
CP972_RS24210	COG2409	Drug exporters of the RND superfamily
CP972_RS24215	COG1846	Transcriptional regulator
CP972_RS24255	COG0745	RESPONSE REGULATOR receiver
CP972_RS24260	COG0018	arginyl-trna synthetase
CP972_RS24265	COG0019	diaminopimelate decarboxylase activity
CP972_RS24270	COG0460	homoserine dehydrogenase
CP972_RS24275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP972_RS24280	COG0083	homoserine kinase activity
CP972_RS24295	COG0254	rRNA binding
CP972_RS24300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP972_RS24305	COG2890	protein-(glutamine-N5) methyltransferase activity
CP972_RS24315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP972_RS24320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP972_RS24325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP972_RS24340	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP972_RS24345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP972_RS24350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP972_RS24355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP972_RS24360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP972_RS24365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP972_RS24370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP972_RS24385	COG2197	response regulator
CP972_RS24390	COG4585	Histidine kinase
CP972_RS24415	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP972_RS24430	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CP972_RS24465	COG1131	(ABC) transporter
CP972_RS24485	COG0183	Belongs to the thiolase family
CP972_RS24500	COG0745	RESPONSE REGULATOR receiver
CP972_RS24565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS24565	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS24605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CP972_RS24610	COG0857	belongs to the CobB CobQ family
CP972_RS24610	COG0280	phosphate acetyltransferase
CP972_RS24620	COG0205	6-phosphofructokinase activity
CP972_RS24625	COG4565	transcriptional regulatory protein
CP972_RS24630	COG3290	protein histidine kinase activity
CP972_RS24635	COG1301	dicarboxylic acid transport
CP972_RS24645	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP972_RS24660	COG0366	Alpha amylase catalytic
CP972_RS24665	COG0058	SHG alpha-glucan phosphorylase activity
CP972_RS24680	COG1132	(ABC) transporter
CP972_RS24685	COG1132	(ABC) transporter
CP972_RS24695	COG3119	arylsulfatase activity
CP972_RS24710	COG1376	ErfK ybiS ycfS ynhG family protein
CP972_RS24725	COG1278	Cold shock
CP972_RS24740	COG1760	l-serine dehydratase
CP972_RS24745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP972_RS24750	COG0509	glycine decarboxylation via glycine cleavage system
CP972_RS24755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP972_RS24775	COG0747	negative chemotaxis
CP972_RS24780	COG0601	transmembrane transport
CP972_RS24785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP972_RS24790	COG0444	Belongs to the ABC transporter superfamily
CP972_RS24795	COG4608	Belongs to the ABC transporter superfamily
CP972_RS24800	COG2860	membrane
CP972_RS24810	COG1309	transcriptional regulator
CP972_RS24830	COG0482	sulfurtransferase activity
CP972_RS24845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP972_RS24875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CP972_RS24895	COG1611	Belongs to the LOG family
CP972_RS24900	COG4221	oxidoreductase activity
CP972_RS24910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP972_RS24920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP972_RS24925	COG0154	amidase activity
CP972_RS24935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP972_RS24940	COG2226	methyltransferase
CP972_RS24950	COG2409	Drug exporters of the RND superfamily
CP972_RS24955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP972_RS24975	COG0667	Aldo Keto reductase
CP972_RS24985	COG5001	Diguanylate cyclase
CP972_RS25000	COG0440	acetolactate synthase activity
CP972_RS25005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP972_RS25015	COG0477	Major facilitator Superfamily
CP972_RS25025	COG2508	Transcriptional regulator
CP972_RS25030	COG0506	proline dehydrogenase activity
CP972_RS25035	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS25045	COG0473	3-isopropylmalate dehydrogenase activity
CP972_RS25050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP972_RS25055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP972_RS25095	COG2018	Roadblock/LC7 domain
CP972_RS25115	COG2018	Roadblock/LC7 domain
CP972_RS25120	COG5002	protein histidine kinase activity
CP972_RS25130	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP972_RS25135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP972_RS25170	COG1414	Transcriptional regulator
CP972_RS25175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP972_RS25180	COG0066	3-isopropylmalate dehydratase activity
CP972_RS25190	COG0776	regulation of translation
CP972_RS25200	COG1920	GTP binding
CP972_RS25210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP972_RS25215	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP972_RS25235	COG0351	phosphomethylpyrimidine kinase
CP972_RS25240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP972_RS25245	COG1461	Dihydroxyacetone kinase
CP972_RS25255	COG0326	Molecular chaperone. Has ATPase activity
CP972_RS25265	COG0742	ribosomal rna small subunit methyltransferase
CP972_RS25270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP972_RS25285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CP972_RS25290	COG0571	ribonuclease III activity
CP972_RS25295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP972_RS25300	COG1733	regulation of RNA biosynthetic process
CP972_RS25305	COG2340	Cysteine-rich secretory protein family
CP972_RS25310	COG1254	Belongs to the acylphosphatase family
CP972_RS25320	COG1196	nuclear chromosome segregation
CP972_RS25325	COG0477	Major facilitator Superfamily
CP972_RS25355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP972_RS25375	COG0228	four-way junction DNA binding
CP972_RS25380	COG1837	Belongs to the UPF0109 family
CP972_RS25385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP972_RS25390	COG0336	Belongs to the RNA methyltransferase TrmD family
CP972_RS25395	COG0335	large ribosomal subunit rRNA binding
CP972_RS25410	COG0681	Belongs to the peptidase S26 family
CP972_RS25430	COG0792	nuclease activity
CP972_RS25445	COG1191	sigma factor activity
CP972_RS25455	COG4942	peptidase
CP972_RS25460	COG0052	Belongs to the universal ribosomal protein uS2 family
CP972_RS25465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP972_RS25470	COG0528	UMP kinase activity
CP972_RS25475	COG0233	cytoplasmic translational termination
CP972_RS25480	COG0575	Belongs to the CDS family
CP972_RS25485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP972_RS25495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CP972_RS25500	COG3842	ATPase activity
CP972_RS25525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP972_RS25535	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS25545	COG0584	glycerophosphoryl diester phosphodiesterase
CP972_RS25550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP972_RS25565	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS25575	COG3842	ATPase activity
CP972_RS25585	COG1177	transmembrane transport
CP972_RS25590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP972_RS25615	COG2508	Transcriptional regulator
CP972_RS25620	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS25635	COG4209	transmembrane transport
CP972_RS25640	COG0395	ABC-type sugar transport system, permease component
CP972_RS25670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP972_RS25675	COG0750	zinc metalloprotease
CP972_RS25680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP972_RS25695	COG0442	prolyl-tRNA aminoacylation
CP972_RS25715	COG0779	Required for maturation of 30S ribosomal subunits
CP972_RS25730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP972_RS25740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP972_RS25745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP972_RS25765	COG0444	Belongs to the ABC transporter superfamily
CP972_RS25775	COG0601	transmembrane transport
CP972_RS25780	COG0747	negative chemotaxis
CP972_RS25785	COG0455	bacterial-type flagellum organization
CP972_RS25800	COG3266	domain, Protein
CP972_RS25805	COG1404	Belongs to the peptidase S8 family
CP972_RS25840	COG1404	Belongs to the peptidase S8 family
CP972_RS25860	COG1674	ftsk spoiiie
CP972_RS25875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP972_RS25880	COG1185	polyribonucleotide nucleotidyltransferase activity
CP972_RS25885	COG0612	Peptidase, M16
CP972_RS25890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP972_RS25910	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CP972_RS25915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP972_RS25920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP972_RS25955	COG2208	phosphoserine phosphatase activity
CP972_RS25955	COG2770	Histidine kinase
CP972_RS25965	COG4999	Histidine kinase
CP972_RS25965	COG3437	response regulator, receiver
CP972_RS25965	COG3850	Histidine kinase
CP972_RS25965	COG2205	protein histidine kinase activity
CP972_RS25975	COG1674	ftsk spoiiie
CP972_RS25985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP972_RS25995	COG1058	Belongs to the CinA family
CP972_RS25995	COG1546	Belongs to the CinA family
CP972_RS26000	COG1396	sequence-specific DNA binding
CP972_RS26005	COG0783	Belongs to the Dps family
CP972_RS26015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP972_RS26020	COG1201	RNA secondary structure unwinding
CP972_RS26045	COG0628	permease
CP972_RS26050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CP972_RS26060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP972_RS26070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP972_RS26075	COG0765	amino acid transport
CP972_RS26080	COG0765	amino acid transport
CP972_RS26085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP972_RS26090	COG1126	abc transporter atp-binding protein
CP972_RS26095	COG0745	RESPONSE REGULATOR receiver
CP972_RS26100	COG2205	protein histidine kinase activity
CP972_RS26105	COG2358	TRAP transporter, solute receptor (TAXI family
CP972_RS26115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP972_RS26130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP972_RS26140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP972_RS26145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP972_RS26155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP972_RS26170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP972_RS26175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP972_RS26180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP972_RS26195	COG0588	phosphoglycerate mutase activity
CP972_RS26210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP972_RS26225	COG0514	ATP-dependent DNA helicase (RecQ)
CP972_RS26245	COG1802	Transcriptional regulator
CP972_RS26250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP972_RS26265	COG0187	DNA topoisomerase II activity
CP972_RS26275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP972_RS26290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP972_RS26295	COG0612	Peptidase, M16
CP972_RS26310	COG1802	Transcriptional regulator
CP972_RS26315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP972_RS26325	COG1042	CoA-binding domain protein
CP972_RS26325	COG0045	succinate-CoA ligase (ADP-forming) activity
CP972_RS26325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP972_RS26335	COG2111	Na H antiporter
CP972_RS26335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP972_RS26340	COG1006	Multisubunit Na H antiporter MnhC subunit
CP972_RS26345	COG0651	ATP synthesis coupled electron transport
CP972_RS26360	COG1320	monovalent cation:proton antiporter activity
CP972_RS26375	COG1435	thymidine kinase activity
CP972_RS26385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP972_RS26390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP972_RS26410	COG0832	Belongs to the urease beta subunit family
CP972_RS26415	COG0804	urea catabolic process
CP972_RS26425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP972_RS26430	COG0829	nickel cation binding
CP972_RS26495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP972_RS26505	COG0745	RESPONSE REGULATOR receiver
CP972_RS26510	COG2205	protein histidine kinase activity
CP972_RS26535	COG0756	dUTP diphosphatase activity
CP972_RS26570	COG0569	domain protein
CP972_RS26575	COG0531	amino acid
CP972_RS26580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP972_RS26630	COG2801	Transposase and inactivated derivatives
CP972_RS26645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP972_RS26655	COG0243	molybdopterin cofactor binding
CP972_RS26690	COG0577	efflux transmembrane transporter activity
CP972_RS26690	COG1136	(ABC) transporter
CP972_RS26695	COG0577	efflux transmembrane transporter activity
CP972_RS26730	COG0596	Alpha beta hydrolase
CP972_RS26760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP972_RS26765	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS26770	COG0531	amino acid
CP972_RS26790	COG2010	Cytochrome c
CP972_RS26790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP972_RS26825	COG0142	geranyltranstransferase activity
CP972_RS26840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP972_RS26855	COG0543	2 iron, 2 sulfur cluster binding
CP972_RS26855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP972_RS26860	COG1124	(ABC) transporter
CP972_RS26865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP972_RS26870	COG0601	transmembrane transport
CP972_RS26895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP972_RS26915	COG2890	protein-(glutamine-N5) methyltransferase activity
CP972_RS26930	COG0723	plastoquinol--plastocyanin reductase activity
CP972_RS26930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP972_RS26945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP972_RS26950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP972_RS26965	COG0644	oxidoreductase
CP972_RS27005	COG0604	alcohol dehydrogenase
CP972_RS27005	COG3321	synthase
CP972_RS27010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP972_RS27010	COG3321	synthase
CP972_RS27010	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS27010	COG4221	oxidoreductase activity
CP972_RS27020	COG4335	DNA alkylation repair
CP972_RS27045	COG0477	Major facilitator Superfamily
CP972_RS27100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP972_RS27105	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CP972_RS27110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP972_RS27115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP972_RS27120	COG1120	ATPase activity
CP972_RS27160	COG3226	Transcriptional regulator
CP972_RS27165	COG2188	Transcriptional regulator
CP972_RS27170	COG2182	Extracellular solute-binding protein
CP972_RS27175	COG1175	transmembrane transport
CP972_RS27180	COG0395	ABC-type sugar transport system, permease component
CP972_RS27185	COG1472	Belongs to the glycosyl hydrolase 3 family
CP972_RS27195	COG1309	transcriptional regulator
CP972_RS27200	COG1414	Transcriptional regulator
CP972_RS27210	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP972_RS27220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP972_RS27225	COG1253	flavin adenine dinucleotide binding
CP972_RS27240	COG1799	cell septum assembly
CP972_RS27275	COG2329	Antibiotic biosynthesis monooxygenase
CP972_RS27290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP972_RS27300	COG2235	arginine
CP972_RS27305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP972_RS27350	COG2755	lipolytic protein G-D-S-L family
CP972_RS27355	COG2124	cytochrome p450
CP972_RS27370	COG0601	transmembrane transport
CP972_RS27375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP972_RS27380	COG0444	Belongs to the ABC transporter superfamily
CP972_RS27385	COG1124	(ABC) transporter
CP972_RS27400	COG0583	DNA-binding transcription factor activity
CP972_RS27405	COG0183	Belongs to the thiolase family
CP972_RS27415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CP972_RS27425	COG0726	polysaccharide deacetylase
CP972_RS27450	COG0477	Major facilitator Superfamily
CP972_RS27465	COG4106	trans-aconitate 2-methyltransferase activity
CP972_RS27570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP972_RS27575	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CP972_RS27580	COG3971	2-oxopent-4-enoate hydratase activity
CP972_RS27585	COG1414	Transcriptional regulator
CP972_RS27600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP972_RS27620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP972_RS27625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP972_RS27635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP972_RS27645	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP972_RS27650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP972_RS27690	COG0640	Transcriptional regulator
CP972_RS27700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CP972_RS27705	COG0569	domain protein
CP972_RS27725	COG0515	serine threonine protein kinase
CP972_RS27745	COG2203	Gaf domain
CP972_RS27745	COG4585	Histidine kinase
CP972_RS27760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP972_RS27770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP972_RS27805	COG1653	transport
CP972_RS27810	COG1175	transmembrane transport
CP972_RS27815	COG0395	ABC-type sugar transport system, permease component
CP972_RS27820	COG1940	carbohydrate kinase activity
CP972_RS27825	COG4213	ABC transporter substrate-binding protein
CP972_RS27835	COG4214	carbohydrate transport
CP972_RS27840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP972_RS27845	COG0531	amino acid
CP972_RS27855	COG1024	Enoyl-CoA hydratase
CP972_RS27855	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP972_RS27860	COG0183	Belongs to the thiolase family
CP972_RS27870	COG1175	transmembrane transport
CP972_RS27880	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP972_RS27895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP972_RS27910	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS27950	COG2188	Transcriptional regulator
CP972_RS27955	COG3842	ATPase activity
CP972_RS27960	COG0395	ABC-type sugar transport system, permease component
CP972_RS27980	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP972_RS28005	COG2814	Major facilitator Superfamily
CP972_RS28015	COG2814	Major facilitator Superfamily
CP972_RS28025	COG1609	Transcriptional regulator
CP972_RS28035	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP972_RS28045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP972_RS28060	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP972_RS28060	COG1902	pentaerythritol trinitrate reductase activity
CP972_RS28070	COG0346	lactoylglutathione lyase activity
CP972_RS28095	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP972_RS28105	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP972_RS28110	COG3253	May function as heme-dependent peroxidase
CP972_RS28115	COG3220	belongs to the UPF0276 family
CP972_RS28135	COG3903	Transcriptional regulator
CP972_RS28135	COG3629	intracellular signal transduction
CP972_RS28145	COG0596	Alpha beta hydrolase
CP972_RS28165	COG0640	Transcriptional regulator
CP972_RS28180	COG0330	HflC and HflK could
CP972_RS28200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP972_RS28205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP972_RS28215	COG1174	glycine betaine transport
CP972_RS28220	COG1174	glycine betaine transport
CP972_RS28225	COG1732	Glycine betaine
CP972_RS28255	COG1309	transcriptional regulator
CP972_RS28345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP972_RS28350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CP972_RS28375	COG0529	Catalyzes the synthesis of activated sulfate
CP972_RS28380	COG0175	sulfate reduction
CP972_RS28390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP972_RS28410	COG1960	acyl-CoA dehydrogenase activity
CP972_RS28420	COG1917	Cupin 2, conserved barrel domain protein
CP972_RS28420	COG4977	sequence-specific DNA binding
CP972_RS28440	COG0460	homoserine dehydrogenase
CP972_RS28460	COG2040	homocysteine
CP972_RS28510	COG0395	ABC-type sugar transport system, permease component
CP972_RS28515	COG1175	transmembrane transport
CP972_RS28525	COG1940	carbohydrate kinase activity
CP972_RS28530	COG0277	FAD linked oxidase domain protein
CP972_RS28545	COG1162	GTPase activity
CP972_RS28570	COG0028	Belongs to the TPP enzyme family
CP972_RS28600	COG1802	Transcriptional regulator
CP972_RS28625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP972_RS28650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP972_RS28690	COG2351	hydroxyisourate hydrolase activity
CP972_RS28705	COG1874	Beta-galactosidase
CP972_RS28705	COG0366	Alpha amylase catalytic
CP972_RS28725	COG2814	Major facilitator Superfamily
CP972_RS28740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP972_RS28755	COG0436	Aminotransferase
CP972_RS28785	COG3467	pyridoxamine 5'-phosphate
CP972_RS28790	COG2368	4-hydroxyphenylacetate
CP972_RS28795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP972_RS28800	COG2267	carboxylic ester hydrolase activity
CP972_RS28810	COG0346	lactoylglutathione lyase activity
CP972_RS28820	COG1116	anion transmembrane transporter activity
CP972_RS28830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP972_RS28850	COG2267	carboxylic ester hydrolase activity
CP972_RS28860	COG0783	Belongs to the Dps family
CP972_RS28900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP972_RS28905	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CP972_RS28925	COG0142	geranyltranstransferase activity
CP972_RS28965	COG1846	Transcriptional regulator
CP972_RS28975	COG3903	Transcriptional regulator
CP972_RS28975	COG3629	intracellular signal transduction
CP972_RS28990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP972_RS28995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP972_RS29010	COG3424	synthase
CP972_RS29050	COG0251	oxidation-reduction process
CP972_RS29055	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS29065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CP972_RS29085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CP972_RS29090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP972_RS29100	COG1414	Transcriptional regulator
CP972_RS29105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP972_RS29110	COG4266	Belongs to the allantoicase family
CP972_RS29115	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS29130	COG2197	response regulator
CP972_RS29140	COG2188	Transcriptional regulator
CP972_RS29145	COG1940	carbohydrate kinase activity
CP972_RS29155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP972_RS29180	COG0438	transferase activity, transferring glycosyl groups
CP972_RS29190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP972_RS29195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP972_RS29220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP972_RS29270	COG2124	cytochrome p450
CP972_RS29285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP972_RS29295	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP972_RS29300	COG0596	Alpha beta hydrolase
CP972_RS29305	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP972_RS29310	COG0708	Exodeoxyribonuclease III
CP972_RS29325	COG0405	Gamma-glutamyltransferase
CP972_RS29330	COG0542	response to heat
CP972_RS29335	COG0024	Methionine aminopeptidase
CP972_RS29360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP972_RS29365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS29405	COG0095	Lipoate-protein ligase
CP972_RS29425	COG0444	Belongs to the ABC transporter superfamily
CP972_RS29435	COG4166	transmembrane transport
CP972_RS29445	COG3458	cephalosporin-C deacetylase activity
CP972_RS29455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP972_RS29465	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CP972_RS29475	COG1120	ATPase activity
CP972_RS29490	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP972_RS29520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP972_RS29540	COG0483	inositol monophosphate 1-phosphatase activity
CP972_RS29555	COG2376	Dihydroxyacetone kinase
CP972_RS29560	COG2376	Dihydroxyacetone kinase
CP972_RS29605	COG1929	Belongs to the glycerate kinase type-1 family
CP972_RS29615	COG0688	phosphatidylethanolamine metabolic process
CP972_RS29620	COG1960	acyl-CoA dehydrogenase activity
CP972_RS29630	COG2301	Belongs to the HpcH HpaI aldolase family
CP972_RS29635	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS29635	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP972_RS29640	COG0604	alcohol dehydrogenase
CP972_RS29650	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP972_RS29665	COG0596	Alpha beta hydrolase
CP972_RS29680	COG2362	D-Aminopeptidase
CP972_RS29685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP972_RS29695	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP972_RS29725	COG1793	dna ligase
CP972_RS29725	COG3285	dna ligase
CP972_RS29790	COG0488	(ABC) transporter
CP972_RS29800	COG0693	protein deglycase activity
CP972_RS29835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP972_RS29865	COG0443	Heat shock 70 kDa protein
CP972_RS29885	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP972_RS29890	COG4106	trans-aconitate 2-methyltransferase activity
CP972_RS29890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP972_RS29895	COG1609	Transcriptional regulator
CP972_RS29900	COG0395	ABC-type sugar transport system, permease component
CP972_RS29905	COG1175	transmembrane transport
CP972_RS29915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS29920	COG3401	FG-GAP repeat protein
CP972_RS29930	COG4733	cellulase activity
CP972_RS29930	COG5297	Belongs to the glycosyl hydrolase family 6
CP972_RS29935	COG5297	Belongs to the glycosyl hydrolase family 6
CP972_RS29945	COG0656	L-ascorbic acid biosynthetic process
CP972_RS29950	COG1022	Amp-dependent synthetase and ligase
CP972_RS29965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP972_RS29985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP972_RS29990	COG1940	carbohydrate kinase activity
CP972_RS29995	COG1129	ABC transporter
CP972_RS30000	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP972_RS30010	COG0673	inositol 2-dehydrogenase activity
CP972_RS30160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP972_RS30165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP972_RS30180	COG0477	Major facilitator Superfamily
CP972_RS30185	COG0477	Major facilitator Superfamily
CP972_RS30190	COG1957	nucleoside hydrolase
CP972_RS30195	COG1609	Transcriptional regulator
CP972_RS30200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP972_RS30210	COG4104	PAAR repeat-containing protein
CP972_RS30210	COG3209	COG3209 Rhs family protein
CP972_RS30245	COG1201	RNA secondary structure unwinding
CP972_RS30270	COG1017	nitric oxide dioxygenase activity
CP972_RS30270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP972_RS30310	COG1012	belongs to the aldehyde dehydrogenase family
CP972_RS30320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP972_RS30325	COG0730	response to heat
CP972_RS30340	COG1349	DNA-binding transcription factor activity
CP972_RS30345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP972_RS30360	COG0488	(ABC) transporter
CP972_RS30380	COG2319	Wd-40 repeat
CP972_RS30380	COG4249	Peptidase C14 caspase catalytic subunit p20
CP972_RS30405	COG0477	Major facilitator Superfamily
CP972_RS30420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP972_RS30480	COG0438	transferase activity, transferring glycosyl groups
CP972_RS30500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP972_RS30510	COG3467	pyridoxamine 5'-phosphate
CP972_RS30515	COG0346	lactoylglutathione lyase activity
CP972_RS30520	COG0477	Major facilitator Superfamily
CP972_RS30530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP972_RS30535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP972_RS30535	COG1082	Xylose isomerase domain protein TIM barrel
CP972_RS30540	COG0588	phosphoglycerate mutase activity
CP972_RS30545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP972_RS30565	COG1486	melibiose metabolic process
CP972_RS30575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP972_RS30600	COG1653	transport
CP972_RS30605	COG1175	transmembrane transport
CP972_RS30610	COG0395	ABC-type sugar transport system, permease component
CP972_RS30615	COG0366	Alpha amylase catalytic
CP972_RS30620	COG1116	anion transmembrane transporter activity
CP972_RS30625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP972_RS30630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP972_RS30640	COG1414	Transcriptional regulator
CP972_RS30655	COG1309	transcriptional regulator
CP972_RS30665	COG1672	PFAM Archaeal ATPase
CP972_RS30665	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP972_RS30670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP972_RS30680	COG3485	protocatechuate 3,4-dioxygenase
CP972_RS30685	COG3485	protocatechuate 3,4-dioxygenase
CP972_RS30690	COG1846	Transcriptional regulator
CP972_RS30740	COG0488	(ABC) transporter
CP972_RS30755	COG1515	deoxyribonuclease V activity
CP972_RS30765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP972_RS30770	COG0183	Belongs to the thiolase family
CP972_RS30775	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP972_RS30775	COG1024	Enoyl-CoA hydratase
CP972_RS30790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP972_RS30805	COG0488	(ABC) transporter
CP972_RS30815	COG2183	response to ionizing radiation
CP972_RS30820	COG1024	Enoyl-CoA hydratase
CP972_RS30835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP972_RS30880	COG1388	LysM domain
CP972_RS30880	COG1134	teichoic acid transport
CP972_RS30885	COG1562	ergosterol biosynthetic process
CP972_RS30895	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP972_RS30935	COG2365	Tyrosine phosphatase family
CP972_RS30940	COG0741	lytic transglycosylase activity
CP972_RS30940	COG1196	nuclear chromosome segregation
CP972_RS30940	COG0739	heme binding
CP972_RS30945	COG2755	lipolytic protein G-D-S-L family
CP972_RS30980	COG1063	alcohol dehydrogenase
CP972_RS30985	COG0156	8-amino-7-oxononanoate synthase activity
CP972_RS30990	COG0583	DNA-binding transcription factor activity
CP972_RS31000	COG3958	Transketolase
CP972_RS31005	COG3959	Transketolase, thiamine diphosphate binding domain
CP972_RS31080	COG2188	Transcriptional regulator
CP972_RS31090	COG3962	Belongs to the TPP enzyme family
CP972_RS31095	COG3718	enzyme involved in inositol metabolism
CP972_RS31105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP972_RS31130	COG0673	inositol 2-dehydrogenase activity
CP972_RS31150	COG0673	inositol 2-dehydrogenase activity
CP972_RS31155	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS31170	COG3548	integral membrane protein
CP972_RS31175	COG0673	inositol 2-dehydrogenase activity
CP972_RS31200	COG1404	Belongs to the peptidase S8 family
CP972_RS31220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP972_RS31230	COG2838	Isocitrate dehydrogenase
CP972_RS31235	COG0668	transmembrane transport
CP972_RS31240	COG1132	(ABC) transporter
CP972_RS31245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP972_RS31245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP972_RS31255	COG2197	response regulator
CP972_RS31260	COG3851	Histidine kinase
CP972_RS31310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP972_RS31315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS31320	COG1960	acyl-CoA dehydrogenase activity
CP972_RS31325	COG0183	Belongs to the thiolase family
CP972_RS31330	COG1024	Enoyl-CoA hydratase
CP972_RS31330	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP972_RS31335	COG1022	Amp-dependent synthetase and ligase
CP972_RS31340	COG1960	acyl-CoA dehydrogenase activity
CP972_RS31345	COG1309	transcriptional regulator
CP972_RS31390	COG0531	amino acid
CP972_RS31405	COG1132	(ABC) transporter
CP972_RS31425	COG0596	Alpha beta hydrolase
CP972_RS31435	COG0542	response to heat
CP972_RS31470	COG2124	cytochrome p450
CP972_RS31490	COG3251	PFAM MbtH domain protein
CP972_RS31505	COG3973	AAA domain
CP972_RS31520	COG0110	maltose O-acetyltransferase activity
CP972_RS31555	COG1609	Transcriptional regulator
CP972_RS31565	COG1175	transmembrane transport
CP972_RS31575	COG1472	Belongs to the glycosyl hydrolase 3 family
CP972_RS31605	COG4585	Histidine kinase
CP972_RS31610	COG2197	response regulator
CP972_RS31615	COG1132	(ABC) transporter
CP972_RS31630	COG0395	ABC-type sugar transport system, permease component
CP972_RS31655	COG2186	Transcriptional regulator
CP972_RS31660	COG3618	amidohydrolase
CP972_RS31680	COG4948	Mandelate Racemase Muconate Lactonizing
CP972_RS31685	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP972_RS31695	COG0832	Belongs to the urease beta subunit family
CP972_RS31695	COG0831	urea catabolic process
CP972_RS31700	COG0804	urea catabolic process
CP972_RS31705	COG0830	nickel cation binding
CP972_RS31710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP972_RS31715	COG0829	nickel cation binding
CP972_RS31720	COG1472	Belongs to the glycosyl hydrolase 3 family
CP972_RS31760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CP972_RS31775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CP972_RS31790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP972_RS31795	COG3250	beta-galactosidase activity
CP972_RS31865	COG0726	polysaccharide deacetylase
CP972_RS31905	COG0583	DNA-binding transcription factor activity
CP972_RS31915	COG1053	succinate dehydrogenase
CP972_RS31920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP972_RS31940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS31950	COG3360	Dodecin
CP972_RS31970	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP972_RS31975	COG0121	glutamine amidotransferase
CP972_RS31980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP972_RS32005	COG1335	isochorismatase
CP972_RS32025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP972_RS32035	COG0739	heme binding
CP972_RS32045	COG2080	2 iron, 2 sulfur cluster binding
CP972_RS32050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP972_RS32055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP972_RS32075	COG1609	Transcriptional regulator
CP972_RS32085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP972_RS32095	COG0242	peptide deformylase activity
CP972_RS32160	COG0714	Associated with various cellular activities
CP972_RS32180	COG0071	Belongs to the small heat shock protein (HSP20) family
CP972_RS32225	COG1278	Cold shock
CP972_RS32240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP972_RS32245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP972_RS32270	COG2197	response regulator
CP972_RS32275	COG4585	Histidine kinase
CP972_RS32300	COG0318	PFAM AMP-dependent synthetase and ligase
CP972_RS32310	COG0183	Belongs to the thiolase family
CP972_RS32315	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS32345	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CP972_RS32365	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP972_RS32380	COG0402	S-adenosylhomocysteine deaminase activity
CP972_RS32400	COG2197	response regulator
CP972_RS32425	COG2326	polyphosphate kinase activity
CP972_RS32430	COG2181	nitrate reductase activity
CP972_RS32440	COG1140	nitrate reductase beta subunit
CP972_RS32475	COG1140	nitrate reductase beta subunit
CP972_RS32520	COG1556	Lactate utilization protein
CP972_RS32530	COG0247	lactate metabolic process
CP972_RS32535	COG1070	Carbohydrate kinase
CP972_RS32540	COG3347	Dehydrogenase
CP972_RS32540	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS32550	COG1129	ABC transporter
CP972_RS32555	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP972_RS32560	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP972_RS32580	COG1609	Transcriptional regulator
CP972_RS32595	COG1357	PFAM Pentapeptide repeats (8 copies)
CP972_RS32605	COG1309	transcriptional regulator
CP972_RS32660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP972_RS32695	COG2124	cytochrome p450
CP972_RS32810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CP972_RS32845	COG1132	(ABC) transporter
CP972_RS32860	COG1028	Short-chain dehydrogenase reductase Sdr
CP972_RS32910	COG1072	(Pantothenic acid kinase))
CP972_RS32940	COG1132	(ABC) transporter
CP972_RS33010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP972_RS33010	COG1017	nitric oxide dioxygenase activity
CP972_RS33045	COG3290	protein histidine kinase activity
CP972_RS33090	COG2508	Transcriptional regulator
CP972_RS33100	COG0789	Transcriptional regulator
CP972_RS33105	COG0410	ABC transporter
CP972_RS33115	COG0559	Belongs to the binding-protein-dependent transport system permease family
CP972_RS33135	COG0667	Aldo Keto reductase
CP972_RS33165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP972_RS33180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP972_RS33205	COG1120	ATPase activity
CP972_RS33210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CP972_RS33230	COG1501	Belongs to the glycosyl hydrolase 31 family
CP972_RS33235	COG1653	transport
CP972_RS33240	COG1175	transmembrane transport
CP972_RS33245	COG0395	ABC-type sugar transport system, permease component
CP972_RS33255	COG0516	GMP reductase activity
CP972_RS33255	COG0517	IMP dehydrogenase activity
CP972_RS33265	COG0409	Hydrogenase expression formation protein
CP972_RS33270	COG0298	carbon dioxide binding
CP972_RS33275	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CP972_RS33280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP972_RS33285	COG0375	protein maturation
CP972_RS33315	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CP972_RS33325	COG1024	Enoyl-CoA hydratase
CP972_RS33325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP972_RS33380	COG2080	2 iron, 2 sulfur cluster binding
CP972_RS33385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP972_RS33390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP972_RS33410	COG1024	Enoyl-CoA hydratase
CP972_RS33475	COG3594	Acyltransferase
CP972_RS33480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP972_RS33510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP972_RS33530	COG1191	sigma factor activity
CP972_RS33540	COG0596	Alpha beta hydrolase
CP972_RS33590	COG2226	methyltransferase
CP972_RS33600	COG0789	Transcriptional regulator
CP972_RS33625	COG4941	Belongs to the sigma-70 factor family
CP972_RS33630	COG3795	YCII-related domain
CP972_RS33635	COG1819	glycosyl
CP972_RS33640	COG3507	Belongs to the glycosyl hydrolase 43 family
CP972_RS33725	COG0435	Glutathione S-transferase
CP972_RS33740	COG1132	(ABC) transporter
CP972_RS33785	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP972_RS33845	COG4585	Histidine kinase
CP972_RS33850	COG2197	response regulator