locus-tag	class	description
SFLA_RS00035	COG4152	abc transporter atp-binding protein
SFLA_RS00060	COG0789	Transcriptional regulator
SFLA_RS00090	COG2124	cytochrome p450
SFLA_RS00105	COG2801	Transposase and inactivated derivatives
SFLA_RS00160	COG0069	glutamate synthase activity
SFLA_RS00185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SFLA_RS00255	COG2072	flavoprotein involved in K transport
SFLA_RS00260	COG0432	Pfam Uncharacterised protein family UPF0047
SFLA_RS00305	COG1609	Transcriptional regulator
SFLA_RS00310	COG1653	transport
SFLA_RS00320	COG0395	ABC-type sugar transport system, permease component
SFLA_RS00345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SFLA_RS00350	COG2423	ornithine cyclodeaminase activity
SFLA_RS00355	COG2197	response regulator
SFLA_RS00365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SFLA_RS00395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS00400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SFLA_RS00415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SFLA_RS00420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SFLA_RS00440	COG2124	cytochrome p450
SFLA_RS00460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS00485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS00490	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SFLA_RS00505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS00520	COG3958	Transketolase
SFLA_RS00525	COG3959	Transketolase, thiamine diphosphate binding domain
SFLA_RS00530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SFLA_RS00535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SFLA_RS00540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SFLA_RS00545	COG0189	ligase activity
SFLA_RS00610	COG0019	diaminopimelate decarboxylase activity
SFLA_RS00625	COG2130	NADP-dependent
SFLA_RS00630	COG1233	COG1233 Phytoene dehydrogenase and related
SFLA_RS00665	COG0010	Belongs to the arginase family
SFLA_RS00670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SFLA_RS00675	COG3191	aminopeptidase activity
SFLA_RS00710	COG0367	asparagine synthase
SFLA_RS00715	COG1032	radical SAM domain protein
SFLA_RS00725	COG2814	Major facilitator Superfamily
SFLA_RS00730	COG0583	DNA-binding transcription factor activity
SFLA_RS00765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SFLA_RS00800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS00805	COG2304	oxidoreductase activity
SFLA_RS00825	COG4124	Belongs to the glycosyl hydrolase 26 family
SFLA_RS00825	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SFLA_RS00895	COG0739	heme binding
SFLA_RS00920	COG0181	hydroxymethylbilane synthase activity
SFLA_RS00955	COG1764	response to oxidative stress
SFLA_RS00960	COG1846	Transcriptional regulator
SFLA_RS00975	COG0277	FAD linked oxidase domain protein
SFLA_RS00985	COG2340	Cysteine-rich secretory protein family
SFLA_RS01005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SFLA_RS01015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SFLA_RS01025	COG2755	lipolytic protein G-D-S-L family
SFLA_RS01030	COG1357	PFAM Pentapeptide repeats (8 copies)
SFLA_RS01045	COG0640	Transcriptional regulator
SFLA_RS01050	COG4952	isomerase
SFLA_RS01055	COG3347	Dehydrogenase
SFLA_RS01055	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS01060	COG1070	Carbohydrate kinase
SFLA_RS01065	COG1024	Enoyl-CoA hydratase
SFLA_RS01090	COG2018	Roadblock/LC7 domain
SFLA_RS01150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SFLA_RS01230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SFLA_RS01230	COG1796	DNA polymerase
SFLA_RS01240	COG2890	protein-(glutamine-N5) methyltransferase activity
SFLA_RS01280	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS01285	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS01315	COG0656	L-ascorbic acid biosynthetic process
SFLA_RS01325	COG3458	cephalosporin-C deacetylase activity
SFLA_RS01365	COG0009	L-threonylcarbamoyladenylate synthase
SFLA_RS01385	COG0640	Transcriptional regulator
SFLA_RS01395	COG2223	nitrite transmembrane transporter activity
SFLA_RS01410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SFLA_RS01415	COG1414	Transcriptional regulator
SFLA_RS01420	COG2382	esterase
SFLA_RS01460	COG1132	(ABC) transporter
SFLA_RS01470	COG1132	(ABC) transporter
SFLA_RS01475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SFLA_RS01480	COG1120	ATPase activity
SFLA_RS01485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS01490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS01495	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SFLA_RS01505	COG1120	ATPase activity
SFLA_RS01555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SFLA_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS01585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SFLA_RS01590	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS01595	COG1982	Orn Lys Arg decarboxylase major
SFLA_RS01605	COG1335	isochorismatase
SFLA_RS01610	COG2045	Belongs to the ComB family
SFLA_RS01620	COG0697	spore germination
SFLA_RS01645	COG0596	Alpha beta hydrolase
SFLA_RS01650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SFLA_RS01685	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SFLA_RS01705	COG0142	geranyltranstransferase activity
SFLA_RS01710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SFLA_RS01725	COG3507	Belongs to the glycosyl hydrolase 43 family
SFLA_RS01740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SFLA_RS01750	COG3537	Alpha-1,2-mannosidase
SFLA_RS01770	COG5002	protein histidine kinase activity
SFLA_RS01785	COG0142	geranyltranstransferase activity
SFLA_RS01795	COG2391	methyltransferase activity
SFLA_RS01800	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS01805	COG0783	Belongs to the Dps family
SFLA_RS01810	COG3469	chitinase activity
SFLA_RS01825	COG4251	negative regulation of phosphorylation
SFLA_RS01830	COG0784	Response regulator, receiver
SFLA_RS01840	COG1064	alcohol dehydrogenase
SFLA_RS01850	COG2188	Transcriptional regulator
SFLA_RS01860	COG1175	transmembrane transport
SFLA_RS01870	COG4948	Mandelate Racemase Muconate Lactonizing
SFLA_RS01895	COG0477	Major facilitator Superfamily
SFLA_RS01920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SFLA_RS01930	COG1609	Transcriptional regulator
SFLA_RS01945	COG3572	ergothioneine biosynthetic process
SFLA_RS01950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SFLA_RS01955	COG0121	glutamine amidotransferase
SFLA_RS01960	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SFLA_RS01975	COG2182	Extracellular solute-binding protein
SFLA_RS01980	COG3360	Dodecin
SFLA_RS02000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SFLA_RS02005	COG1053	succinate dehydrogenase
SFLA_RS02015	COG0583	DNA-binding transcription factor activity
SFLA_RS02060	COG0726	polysaccharide deacetylase
SFLA_RS02085	COG3275	phosphorelay sensor kinase activity
SFLA_RS02090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SFLA_RS02105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SFLA_RS02150	COG2814	Major facilitator Superfamily
SFLA_RS02155	COG1191	sigma factor activity
SFLA_RS02160	COG4566	intracellular signal transduction
SFLA_RS02165	COG4251	negative regulation of phosphorylation
SFLA_RS02170	COG0784	Response regulator, receiver
SFLA_RS02205	COG1175	transmembrane transport
SFLA_RS02210	COG0395	ABC-type sugar transport system, permease component
SFLA_RS02250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SFLA_RS02255	COG1124	(ABC) transporter
SFLA_RS02260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS02290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SFLA_RS02300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SFLA_RS02310	COG1132	(ABC) transporter
SFLA_RS02330	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SFLA_RS02345	COG0019	diaminopimelate decarboxylase activity
SFLA_RS02350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SFLA_RS02370	COG2072	flavoprotein involved in K transport
SFLA_RS02380	COG1309	transcriptional regulator
SFLA_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS02420	COG0589	response to stress
SFLA_RS02425	COG0310	cobalt ion transport
SFLA_RS02430	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SFLA_RS02435	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SFLA_RS02440	COG1122	ATPase activity
SFLA_RS02470	COG2409	Drug exporters of the RND superfamily
SFLA_RS02475	COG1846	Transcriptional regulator
SFLA_RS02490	COG0702	epimerase
SFLA_RS02510	COG1902	pentaerythritol trinitrate reductase activity
SFLA_RS02510	COG0446	pyridine nucleotide-disulphide oxidoreductase
SFLA_RS02565	COG2188	Transcriptional regulator
SFLA_RS02570	COG2159	amidohydrolase
SFLA_RS02585	COG0477	Major facilitator Superfamily
SFLA_RS02585	COG2814	Major facilitator Superfamily
SFLA_RS02595	COG0671	phosphoesterase, PA-phosphatase related
SFLA_RS02600	COG1295	ribonuclease BN
SFLA_RS02630	COG0697	spore germination
SFLA_RS02650	COG4221	oxidoreductase activity
SFLA_RS02655	COG0583	DNA-binding transcription factor activity
SFLA_RS02660	COG0747	negative chemotaxis
SFLA_RS02680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SFLA_RS02695	COG0367	asparagine synthase
SFLA_RS02700	COG0010	Belongs to the arginase family
SFLA_RS02705	COG2175	clavaminate synthase activity
SFLA_RS02710	COG0768	penicillin binding
SFLA_RS02815	COG1672	PFAM Archaeal ATPase
SFLA_RS02815	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SFLA_RS02845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SFLA_RS02865	COG1609	Transcriptional regulator
SFLA_RS02875	COG1175	transmembrane transport
SFLA_RS02880	COG0395	ABC-type sugar transport system, permease component
SFLA_RS02895	COG1556	Lactate utilization protein
SFLA_RS02900	COG1139	Iron-sulfur cluster binding protein
SFLA_RS02905	COG0247	lactate metabolic process
SFLA_RS02910	COG2186	Transcriptional regulator
SFLA_RS02925	COG2197	response regulator
SFLA_RS02960	COG3959	Transketolase, thiamine diphosphate binding domain
SFLA_RS02965	COG3958	Transketolase
SFLA_RS02995	COG1132	(ABC) transporter
SFLA_RS03035	COG0725	ABC transporter, periplasmic molybdate-binding protein
SFLA_RS03055	COG3467	pyridoxamine 5'-phosphate
SFLA_RS03060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SFLA_RS03100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SFLA_RS03110	COG2755	lipolytic protein G-D-S-L family
SFLA_RS03120	COG2365	Tyrosine phosphatase family
SFLA_RS03145	COG1657	PFAM Prenyltransferase squalene oxidase
SFLA_RS03155	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SFLA_RS03165	COG1562	ergosterol biosynthetic process
SFLA_RS03170	COG1134	teichoic acid transport
SFLA_RS03170	COG1388	LysM domain
SFLA_RS03190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SFLA_RS03215	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SFLA_RS03230	COG1024	Enoyl-CoA hydratase
SFLA_RS03240	COG4977	sequence-specific DNA binding
SFLA_RS03250	COG2183	response to ionizing radiation
SFLA_RS03255	COG0488	(ABC) transporter
SFLA_RS03265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SFLA_RS03285	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS03295	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS03310	COG0789	Transcriptional regulator
SFLA_RS03315	COG1250	3-hydroxyacyl-CoA dehydrogenase
SFLA_RS03315	COG1024	Enoyl-CoA hydratase
SFLA_RS03320	COG0183	Belongs to the thiolase family
SFLA_RS03325	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS03330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS03335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFLA_RS03340	COG3268	Saccharopine dehydrogenase
SFLA_RS03345	COG1515	deoxyribonuclease V activity
SFLA_RS03360	COG0488	(ABC) transporter
SFLA_RS03405	COG1793	dna ligase
SFLA_RS03465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SFLA_RS03510	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS03535	COG3012	SEC-C Motif Domain Protein
SFLA_RS03565	COG1486	melibiose metabolic process
SFLA_RS03635	COG1940	carbohydrate kinase activity
SFLA_RS03660	COG2124	cytochrome p450
SFLA_RS03665	COG1132	(ABC) transporter
SFLA_RS03695	COG1136	(ABC) transporter
SFLA_RS03710	COG4176	ABC-type proline glycine betaine transport system permease component
SFLA_RS03715	COG4175	Glycine betaine
SFLA_RS03715	COG0517	IMP dehydrogenase activity
SFLA_RS03725	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS03735	COG1501	Belongs to the glycosyl hydrolase 31 family
SFLA_RS03750	COG4209	transmembrane transport
SFLA_RS03755	COG0395	ABC-type sugar transport system, permease component
SFLA_RS03790	COG2770	Histidine kinase
SFLA_RS03790	COG2208	phosphoserine phosphatase activity
SFLA_RS03795	COG0596	Alpha beta hydrolase
SFLA_RS03800	COG3507	Belongs to the glycosyl hydrolase 43 family
SFLA_RS03930	COG3209	COG3209 Rhs family protein
SFLA_RS03935	COG0515	serine threonine protein kinase
SFLA_RS03940	COG0210	DNA helicase
SFLA_RS03945	COG2353	YceI-like domain
SFLA_RS03950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SFLA_RS04015	COG0346	lactoylglutathione lyase activity
SFLA_RS04020	COG2226	methyltransferase
SFLA_RS04025	COG1869	D-ribose catabolic process
SFLA_RS04030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SFLA_RS04035	COG1172	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS04040	COG1129	ABC transporter
SFLA_RS04045	COG1609	Transcriptional regulator
SFLA_RS04095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SFLA_RS04120	COG1879	ABC-type sugar transport system periplasmic component
SFLA_RS04125	COG1172	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS04130	COG1129	ABC transporter
SFLA_RS04145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SFLA_RS04150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SFLA_RS04195	COG2154	pterin-4-alpha-carbinolamine dehydratase
SFLA_RS04200	COG3619	membrane
SFLA_RS04205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SFLA_RS04205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SFLA_RS04215	COG1077	Cell shape determining protein MreB Mrl
SFLA_RS04220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SFLA_RS04250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SFLA_RS04275	COG1414	Transcriptional regulator
SFLA_RS04305	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SFLA_RS04320	COG1619	proteins homologs of microcin C7 resistance protein MccF
SFLA_RS04330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SFLA_RS04335	COG2362	D-Aminopeptidase
SFLA_RS04340	COG0667	Aldo Keto reductase
SFLA_RS04345	COG0583	DNA-binding transcription factor activity
SFLA_RS04385	COG0596	Alpha beta hydrolase
SFLA_RS04400	COG1250	3-hydroxyacyl-CoA dehydrogenase
SFLA_RS04420	COG0604	alcohol dehydrogenase
SFLA_RS04425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS04425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS04430	COG2301	Belongs to the HpcH HpaI aldolase family
SFLA_RS04440	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS04445	COG0688	phosphatidylethanolamine metabolic process
SFLA_RS04480	COG0559	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS04500	COG1929	Belongs to the glycerate kinase type-1 family
SFLA_RS04515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SFLA_RS04530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SFLA_RS04590	COG0483	inositol monophosphate 1-phosphatase activity
SFLA_RS04605	COG0095	Lipoate-protein ligase
SFLA_RS04610	COG2838	Isocitrate dehydrogenase
SFLA_RS04615	COG2197	response regulator
SFLA_RS04620	COG3851	Histidine kinase
SFLA_RS04630	COG2226	methyltransferase
SFLA_RS04650	COG1132	(ABC) transporter
SFLA_RS04655	COG1132	(ABC) transporter
SFLA_RS04695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SFLA_RS04700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SFLA_RS04750	COG0405	Gamma-glutamyltransferase
SFLA_RS04760	COG2197	response regulator
SFLA_RS04775	COG0577	efflux transmembrane transporter activity
SFLA_RS04775	COG1136	(ABC) transporter
SFLA_RS04780	COG3321	synthase
SFLA_RS04780	COG0604	alcohol dehydrogenase
SFLA_RS04785	COG3321	synthase
SFLA_RS04785	COG0604	alcohol dehydrogenase
SFLA_RS04805	COG3321	synthase
SFLA_RS04805	COG0604	alcohol dehydrogenase
SFLA_RS04810	COG3321	synthase
SFLA_RS04810	COG0604	alcohol dehydrogenase
SFLA_RS04825	COG0019	diaminopimelate decarboxylase activity
SFLA_RS04830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS04850	COG2267	carboxylic ester hydrolase activity
SFLA_RS04860	COG2124	cytochrome p450
SFLA_RS04870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS04870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS04880	COG2755	lipolytic protein G-D-S-L family
SFLA_RS04890	COG0765	amino acid transport
SFLA_RS04895	COG0765	amino acid transport
SFLA_RS04900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFLA_RS04905	COG1126	abc transporter atp-binding protein
SFLA_RS04930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SFLA_RS04935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SFLA_RS04950	COG1940	carbohydrate kinase activity
SFLA_RS04955	COG1129	ABC transporter
SFLA_RS04970	COG2188	Transcriptional regulator
SFLA_RS04975	COG0673	inositol 2-dehydrogenase activity
SFLA_RS04980	COG2197	response regulator
SFLA_RS05010	COG0656	L-ascorbic acid biosynthetic process
SFLA_RS05020	COG4266	Belongs to the allantoicase family
SFLA_RS05025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SFLA_RS05030	COG1414	Transcriptional regulator
SFLA_RS05035	COG1136	(ABC) transporter
SFLA_RS05045	COG4585	Histidine kinase
SFLA_RS05050	COG2197	response regulator
SFLA_RS05065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SFLA_RS05095	COG3864	Putative metallopeptidase domain
SFLA_RS05135	COG2233	PERMEase
SFLA_RS05145	COG2233	PERMEase
SFLA_RS05155	COG2351	hydroxyisourate hydrolase activity
SFLA_RS05175	COG2188	Transcriptional regulator
SFLA_RS05180	COG1653	transport
SFLA_RS05185	COG1175	transmembrane transport
SFLA_RS05190	COG0395	ABC-type sugar transport system, permease component
SFLA_RS05205	COG3622	Belongs to the hyi family
SFLA_RS05210	COG2084	Dehydrogenase
SFLA_RS05215	COG0753	catalase activity
SFLA_RS05225	COG3960	tartronate-semialdehyde synthase activity
SFLA_RS05240	COG0318	PFAM AMP-dependent synthetase and ligase
SFLA_RS05245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SFLA_RS05250	COG2197	response regulator
SFLA_RS05265	COG0435	Glutathione S-transferase
SFLA_RS05270	COG0477	Major facilitator Superfamily
SFLA_RS05325	COG2252	PERMEase
SFLA_RS05330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SFLA_RS05355	COG1802	Transcriptional regulator
SFLA_RS05385	COG0028	Belongs to the TPP enzyme family
SFLA_RS05405	COG1162	GTPase activity
SFLA_RS05450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SFLA_RS05455	COG4608	Belongs to the ABC transporter superfamily
SFLA_RS05460	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS05470	COG4166	transmembrane transport
SFLA_RS05480	COG3458	cephalosporin-C deacetylase activity
SFLA_RS05495	COG2186	Transcriptional regulator
SFLA_RS05500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SFLA_RS05505	COG1940	carbohydrate kinase activity
SFLA_RS05510	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SFLA_RS05525	COG0477	Major facilitator Superfamily
SFLA_RS05535	COG0583	DNA-binding transcription factor activity
SFLA_RS05540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SFLA_RS05545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SFLA_RS05550	COG1250	3-hydroxyacyl-CoA dehydrogenase
SFLA_RS05570	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS05575	COG3284	Transcriptional regulator
SFLA_RS05585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFLA_RS05595	COG0175	sulfate reduction
SFLA_RS05600	COG0529	Catalyzes the synthesis of activated sulfate
SFLA_RS05625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SFLA_RS05630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SFLA_RS05645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SFLA_RS05705	COG1175	transmembrane transport
SFLA_RS05770	COG1072	(Pantothenic acid kinase))
SFLA_RS05775	COG0346	lactoylglutathione lyase activity
SFLA_RS05780	COG0583	DNA-binding transcription factor activity
SFLA_RS05785	COG0156	8-amino-7-oxononanoate synthase activity
SFLA_RS05790	COG1063	alcohol dehydrogenase
SFLA_RS05805	COG0477	Major facilitator Superfamily
SFLA_RS05820	COG1802	Transcriptional regulator
SFLA_RS05825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SFLA_RS05830	COG0402	S-adenosylhomocysteine deaminase activity
SFLA_RS05835	COG1309	transcriptional regulator
SFLA_RS05840	COG2409	Drug exporters of the RND superfamily
SFLA_RS05845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SFLA_RS05850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SFLA_RS05890	COG4152	abc transporter atp-binding protein
SFLA_RS05910	COG3220	belongs to the UPF0276 family
SFLA_RS05925	COG3253	May function as heme-dependent peroxidase
SFLA_RS05930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SFLA_RS05940	COG0446	pyridine nucleotide-disulphide oxidoreductase
SFLA_RS05945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SFLA_RS05965	COG0183	Belongs to the thiolase family
SFLA_RS05970	COG1250	3-hydroxyacyl-CoA dehydrogenase
SFLA_RS05970	COG1024	Enoyl-CoA hydratase
SFLA_RS05985	COG1316	TRANSCRIPTIONal
SFLA_RS05995	COG0531	amino acid
SFLA_RS06000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SFLA_RS06005	COG4214	carbohydrate transport
SFLA_RS06015	COG4213	ABC transporter substrate-binding protein
SFLA_RS06020	COG1940	carbohydrate kinase activity
SFLA_RS06025	COG3409	Peptidoglycan-binding domain 1 protein
SFLA_RS06040	COG0395	ABC-type sugar transport system, permease component
SFLA_RS06045	COG1175	transmembrane transport
SFLA_RS06050	COG1653	transport
SFLA_RS06090	COG0588	phosphoglycerate mutase activity
SFLA_RS06095	COG1501	Belongs to the glycosyl hydrolase 31 family
SFLA_RS06110	COG1175	transmembrane transport
SFLA_RS06115	COG0395	ABC-type sugar transport system, permease component
SFLA_RS06130	COG1940	carbohydrate kinase activity
SFLA_RS06135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SFLA_RS06150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SFLA_RS06245	COG0513	Belongs to the DEAD box helicase family
SFLA_RS06285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SFLA_RS06470	COG2267	carboxylic ester hydrolase activity
SFLA_RS06475	COG3321	synthase
SFLA_RS06475	COG0604	alcohol dehydrogenase
SFLA_RS06480	COG0667	Aldo Keto reductase
SFLA_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS06490	COG1309	transcriptional regulator
SFLA_RS06500	COG1653	transport
SFLA_RS06505	COG3833	ABC-type maltose transport systems, permease component
SFLA_RS06515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SFLA_RS06520	COG1414	Transcriptional regulator
SFLA_RS06550	COG3251	PFAM MbtH domain protein
SFLA_RS06580	COG0714	Associated with various cellular activities
SFLA_RS06585	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SFLA_RS06620	COG0753	catalase activity
SFLA_RS06630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SFLA_RS06635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SFLA_RS06640	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SFLA_RS06680	COG0489	protein tyrosine kinase activity
SFLA_RS06685	COG0297	glycogen (starch) synthase activity
SFLA_RS06700	COG1320	monovalent cation:proton antiporter activity
SFLA_RS06715	COG0651	ATP synthesis coupled electron transport
SFLA_RS06720	COG1006	Multisubunit Na H antiporter MnhC subunit
SFLA_RS06725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SFLA_RS06725	COG2111	Na H antiporter
SFLA_RS06740	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS06760	COG1024	Enoyl-CoA hydratase
SFLA_RS06770	COG0531	amino acid
SFLA_RS06775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SFLA_RS06785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SFLA_RS06795	COG2040	homocysteine
SFLA_RS06820	COG1799	cell septum assembly
SFLA_RS06855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SFLA_RS06895	COG3585	molybdate ion transport
SFLA_RS06915	COG0583	DNA-binding transcription factor activity
SFLA_RS06925	COG4948	Mandelate Racemase Muconate Lactonizing
SFLA_RS06930	COG2610	gluconate transmembrane transporter activity
SFLA_RS06935	COG1414	Transcriptional regulator
SFLA_RS06950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFLA_RS06965	COG0714	Associated with various cellular activities
SFLA_RS06975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SFLA_RS06985	COG1953	Uracil, thiamine, allantoin
SFLA_RS07000	COG1533	DNA photolyase activity
SFLA_RS07005	COG3046	protein related to deoxyribodipyrimidine photolyase
SFLA_RS07010	COG1309	transcriptional regulator
SFLA_RS07075	COG1674	ftsk spoiiie
SFLA_RS07080	COG1404	Belongs to the peptidase S8 family
SFLA_RS07085	COG0464	growth
SFLA_RS07105	COG3291	Pkd domain containing protein
SFLA_RS07105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SFLA_RS07130	COG1120	ATPase activity
SFLA_RS07140	COG2207	Transcriptional regulator
SFLA_RS07145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SFLA_RS07145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SFLA_RS07160	COG1937	Protein conserved in bacteria
SFLA_RS07185	COG3903	Transcriptional regulator
SFLA_RS07185	COG3629	intracellular signal transduction
SFLA_RS07205	COG2366	antibiotic biosynthetic process
SFLA_RS07220	COG0515	serine threonine protein kinase
SFLA_RS07220	COG2815	serine threonine protein kinase
SFLA_RS07230	COG0596	Alpha beta hydrolase
SFLA_RS07235	COG0604	alcohol dehydrogenase
SFLA_RS07240	COG1309	transcriptional regulator
SFLA_RS07245	COG1396	sequence-specific DNA binding
SFLA_RS07270	COG0596	Alpha beta hydrolase
SFLA_RS07280	COG3631	Ketosteroid isomerase-related protein
SFLA_RS07285	COG0702	epimerase
SFLA_RS07290	COG1335	isochorismatase
SFLA_RS07305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SFLA_RS07310	COG0531	amino acid
SFLA_RS07315	COG0569	domain protein
SFLA_RS07345	COG4591	ABC-type transport system involved in lipoprotein release permease component
SFLA_RS07345	COG1136	(ABC) transporter
SFLA_RS07355	COG0756	dUTP diphosphatase activity
SFLA_RS07380	COG2205	protein histidine kinase activity
SFLA_RS07385	COG0745	RESPONSE REGULATOR receiver
SFLA_RS07395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SFLA_RS07430	COG1435	thymidine kinase activity
SFLA_RS07450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SFLA_RS07455	COG1802	Transcriptional regulator
SFLA_RS07470	COG0612	Peptidase, M16
SFLA_RS07475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SFLA_RS07485	COG0372	Belongs to the citrate synthase family
SFLA_RS07490	COG0372	Belongs to the citrate synthase family
SFLA_RS07505	COG3290	protein histidine kinase activity
SFLA_RS07510	COG4565	transcriptional regulatory protein
SFLA_RS07515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SFLA_RS07540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SFLA_RS07545	COG2186	Transcriptional regulator
SFLA_RS07550	COG1129	ABC transporter
SFLA_RS07580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SFLA_RS07595	COG0588	phosphoglycerate mutase activity
SFLA_RS07610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SFLA_RS07615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SFLA_RS07620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SFLA_RS07655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SFLA_RS07665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SFLA_RS07670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SFLA_RS07680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SFLA_RS07695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SFLA_RS07700	COG2358	TRAP transporter, solute receptor (TAXI family
SFLA_RS07705	COG2205	protein histidine kinase activity
SFLA_RS07715	COG1126	abc transporter atp-binding protein
SFLA_RS07720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFLA_RS07725	COG0765	amino acid transport
SFLA_RS07730	COG0765	amino acid transport
SFLA_RS07760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SFLA_RS07795	COG1201	RNA secondary structure unwinding
SFLA_RS07800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SFLA_RS07815	COG0783	Belongs to the Dps family
SFLA_RS07820	COG1396	sequence-specific DNA binding
SFLA_RS07825	COG1058	Belongs to the CinA family
SFLA_RS07825	COG1546	Belongs to the CinA family
SFLA_RS07835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SFLA_RS07845	COG1674	ftsk spoiiie
SFLA_RS07855	COG4999	Histidine kinase
SFLA_RS07855	COG3437	response regulator, receiver
SFLA_RS07855	COG3850	Histidine kinase
SFLA_RS07855	COG2205	protein histidine kinase activity
SFLA_RS07860	COG2208	phosphoserine phosphatase activity
SFLA_RS07860	COG2770	Histidine kinase
SFLA_RS07890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SFLA_RS07895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SFLA_RS07900	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SFLA_RS07920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SFLA_RS07925	COG0612	Peptidase, M16
SFLA_RS07930	COG1185	polyribonucleotide nucleotidyltransferase activity
SFLA_RS07935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SFLA_RS07945	COG1674	ftsk spoiiie
SFLA_RS07950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SFLA_RS07980	COG1404	Belongs to the peptidase S8 family
SFLA_RS07985	COG3266	domain, Protein
SFLA_RS08005	COG0455	bacterial-type flagellum organization
SFLA_RS08010	COG0747	negative chemotaxis
SFLA_RS08015	COG0601	transmembrane transport
SFLA_RS08020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS08025	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS08050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SFLA_RS08055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SFLA_RS08065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SFLA_RS08085	COG0779	Required for maturation of 30S ribosomal subunits
SFLA_RS08105	COG0442	prolyl-tRNA aminoacylation
SFLA_RS08120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SFLA_RS08125	COG0750	zinc metalloprotease
SFLA_RS08130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SFLA_RS08135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SFLA_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS08155	COG2508	Transcriptional regulator
SFLA_RS08185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SFLA_RS08190	COG1177	transmembrane transport
SFLA_RS08195	COG1176	ABC-type spermidine putrescine transport system, permease component I
SFLA_RS08200	COG3842	ATPase activity
SFLA_RS08205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SFLA_RS08225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SFLA_RS08245	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS08255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SFLA_RS08260	COG4181	ATPase activity
SFLA_RS08280	COG3842	ATPase activity
SFLA_RS08295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SFLA_RS08305	COG0233	cytoplasmic translational termination
SFLA_RS08310	COG0528	UMP kinase activity
SFLA_RS08315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SFLA_RS08320	COG0052	Belongs to the universal ribosomal protein uS2 family
SFLA_RS08330	COG1191	sigma factor activity
SFLA_RS08345	COG0792	nuclease activity
SFLA_RS08355	COG1051	belongs to the nudix hydrolase family
SFLA_RS08360	COG0681	Belongs to the peptidase S26 family
SFLA_RS08365	COG0681	Belongs to the peptidase S26 family
SFLA_RS08370	COG0681	Belongs to the peptidase S26 family
SFLA_RS08375	COG0681	Belongs to the peptidase S26 family
SFLA_RS08380	COG0335	large ribosomal subunit rRNA binding
SFLA_RS08385	COG0336	Belongs to the RNA methyltransferase TrmD family
SFLA_RS08390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SFLA_RS08395	COG1837	Belongs to the UPF0109 family
SFLA_RS08400	COG0228	four-way junction DNA binding
SFLA_RS08420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SFLA_RS08450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SFLA_RS08455	COG0477	Major facilitator Superfamily
SFLA_RS08460	COG1196	nuclear chromosome segregation
SFLA_RS08470	COG1254	Belongs to the acylphosphatase family
SFLA_RS08475	COG2340	Cysteine-rich secretory protein family
SFLA_RS08485	COG1733	regulation of RNA biosynthetic process
SFLA_RS08490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SFLA_RS08495	COG0571	ribonuclease III activity
SFLA_RS08500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SFLA_RS08515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SFLA_RS08520	COG0742	ribosomal rna small subunit methyltransferase
SFLA_RS08525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SFLA_RS08530	COG1461	Dihydroxyacetone kinase
SFLA_RS08535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SFLA_RS08540	COG0351	phosphomethylpyrimidine kinase
SFLA_RS08560	COG1181	Belongs to the D-alanine--D-alanine ligase family
SFLA_RS08565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SFLA_RS08575	COG1920	GTP binding
SFLA_RS08585	COG0776	regulation of translation
SFLA_RS08595	COG0066	3-isopropylmalate dehydratase activity
SFLA_RS08600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SFLA_RS08605	COG1414	Transcriptional regulator
SFLA_RS08640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SFLA_RS08645	COG0179	Fumarylacetoacetate (FAA) hydrolase
SFLA_RS08655	COG5002	protein histidine kinase activity
SFLA_RS08660	COG2018	Roadblock/LC7 domain
SFLA_RS08680	COG2018	Roadblock/LC7 domain
SFLA_RS08700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SFLA_RS08710	COG1228	amidohydrolase
SFLA_RS08820	COG1222	aaa ATPase
SFLA_RS08850	COG2326	polyphosphate kinase activity
SFLA_RS08855	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SFLA_RS08860	COG1120	ATPase activity
SFLA_RS08865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS08870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS08885	COG1472	Belongs to the glycosyl hydrolase 3 family
SFLA_RS08895	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS08900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS08905	COG0601	transmembrane transport
SFLA_RS08915	COG4166	transmembrane transport
SFLA_RS08920	COG1609	Transcriptional regulator
SFLA_RS08930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SFLA_RS08940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SFLA_RS08945	COG0473	3-isopropylmalate dehydrogenase activity
SFLA_RS08950	COG1309	transcriptional regulator
SFLA_RS08960	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS08965	COG0506	proline dehydrogenase activity
SFLA_RS08970	COG2508	Transcriptional regulator
SFLA_RS08975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SFLA_RS08980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SFLA_RS08985	COG0440	acetolactate synthase activity
SFLA_RS09005	COG0667	Aldo Keto reductase
SFLA_RS09010	COG2133	pyrroloquinoline quinone binding
SFLA_RS09015	COG2197	response regulator
SFLA_RS09035	COG2409	Drug exporters of the RND superfamily
SFLA_RS09045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SFLA_RS09055	COG0154	amidase activity
SFLA_RS09060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SFLA_RS09070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SFLA_RS09080	COG4221	oxidoreductase activity
SFLA_RS09100	COG0482	sulfurtransferase activity
SFLA_RS09115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SFLA_RS09115	COG0515	serine threonine protein kinase
SFLA_RS09140	COG2378	regulation of single-species biofilm formation
SFLA_RS09150	COG2860	membrane
SFLA_RS09155	COG4608	Belongs to the ABC transporter superfamily
SFLA_RS09160	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS09170	COG0747	negative chemotaxis
SFLA_RS09195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SFLA_RS09200	COG0509	glycine decarboxylation via glycine cleavage system
SFLA_RS09205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SFLA_RS09210	COG1760	l-serine dehydratase
SFLA_RS09225	COG1131	(ABC) transporter
SFLA_RS09280	COG2197	response regulator
SFLA_RS09285	COG4585	Histidine kinase
SFLA_RS09295	COG1131	(ABC) transporter
SFLA_RS09300	COG1132	(ABC) transporter
SFLA_RS09305	COG1132	(ABC) transporter
SFLA_RS09320	COG0058	SHG alpha-glucan phosphorylase activity
SFLA_RS09325	COG0366	Alpha amylase catalytic
SFLA_RS09330	COG0366	Alpha amylase catalytic
SFLA_RS09340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SFLA_RS09345	COG3118	belongs to the thioredoxin family
SFLA_RS09365	COG1301	dicarboxylic acid transport
SFLA_RS09370	COG3290	protein histidine kinase activity
SFLA_RS09375	COG4565	transcriptional regulatory protein
SFLA_RS09385	COG0205	6-phosphofructokinase activity
SFLA_RS09390	COG0857	belongs to the CobB CobQ family
SFLA_RS09390	COG0280	phosphate acetyltransferase
SFLA_RS09395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SFLA_RS09430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS09430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS09490	COG5002	protein histidine kinase activity
SFLA_RS09495	COG0745	RESPONSE REGULATOR receiver
SFLA_RS09510	COG0183	Belongs to the thiolase family
SFLA_RS09565	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SFLA_RS09580	COG1250	3-hydroxyacyl-CoA dehydrogenase
SFLA_RS09595	COG4585	Histidine kinase
SFLA_RS09600	COG2197	response regulator
SFLA_RS09615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SFLA_RS09620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SFLA_RS09625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SFLA_RS09630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SFLA_RS09635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SFLA_RS09640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SFLA_RS09645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SFLA_RS09665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SFLA_RS09670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SFLA_RS09680	COG2890	protein-(glutamine-N5) methyltransferase activity
SFLA_RS09685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SFLA_RS09690	COG0254	rRNA binding
SFLA_RS09695	COG1316	TRANSCRIPTIONal
SFLA_RS09710	COG0083	homoserine kinase activity
SFLA_RS09715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SFLA_RS09720	COG0460	homoserine dehydrogenase
SFLA_RS09725	COG0019	diaminopimelate decarboxylase activity
SFLA_RS09730	COG0018	arginyl-trna synthetase
SFLA_RS09755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SFLA_RS09770	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SFLA_RS09775	COG3285	dna ligase
SFLA_RS09775	COG1793	dna ligase
SFLA_RS09805	COG0768	penicillin binding
SFLA_RS09905	COG0726	polysaccharide deacetylase
SFLA_RS09910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SFLA_RS09920	COG0745	RESPONSE REGULATOR receiver
SFLA_RS09925	COG2205	protein histidine kinase activity
SFLA_RS09930	COG0567	Dehydrogenase, E1 component
SFLA_RS09930	COG0508	dehydrogenase complex catalyzes the overall conversion of
SFLA_RS09965	COG0604	alcohol dehydrogenase
SFLA_RS09970	COG0281	malic enzyme
SFLA_RS09975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFLA_RS09980	COG0765	amino acid transport
SFLA_RS09985	COG1126	abc transporter atp-binding protein
SFLA_RS09990	COG4106	trans-aconitate 2-methyltransferase activity
SFLA_RS10025	COG5640	endopeptidase activity
SFLA_RS10040	COG0142	geranyltranstransferase activity
SFLA_RS10045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SFLA_RS10055	COG0277	FAD linked oxidase domain protein
SFLA_RS10060	COG1959	2 iron, 2 sulfur cluster binding
SFLA_RS10065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SFLA_RS10065	COG1017	nitric oxide dioxygenase activity
SFLA_RS10090	COG2172	sigma factor antagonist activity
SFLA_RS10105	COG1597	lipid kinase activity
SFLA_RS10120	COG0363	glucosamine-6-phosphate deaminase activity
SFLA_RS10125	COG1472	Belongs to the glycosyl hydrolase 3 family
SFLA_RS10130	COG0395	ABC-type sugar transport system, permease component
SFLA_RS10140	COG2182	Extracellular solute-binding protein
SFLA_RS10145	COG2188	Transcriptional regulator
SFLA_RS10190	COG0242	peptide deformylase activity
SFLA_RS10210	COG5662	AntiSigma factor
SFLA_RS10215	COG1595	DNA-templated transcription, initiation
SFLA_RS10225	COG2135	peptidase activity
SFLA_RS10235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SFLA_RS10240	COG1162	GTPase activity
SFLA_RS10245	COG2076	Multidrug Resistance protein
SFLA_RS10250	COG0483	inositol monophosphate 1-phosphatase activity
SFLA_RS10260	COG0753	catalase activity
SFLA_RS10285	COG1615	UPF0182 protein
SFLA_RS10295	COG3480	Lon protease (S16) C-terminal proteolytic domain
SFLA_RS10345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SFLA_RS10395	COG0210	DNA helicase
SFLA_RS10450	COG4172	Belongs to the ABC transporter superfamily
SFLA_RS10460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS10465	COG0747	negative chemotaxis
SFLA_RS10505	COG0513	Belongs to the DEAD box helicase family
SFLA_RS10515	COG1432	Conserved Protein
SFLA_RS10525	COG2095	MarC family integral membrane protein
SFLA_RS10540	COG2814	Major facilitator Superfamily
SFLA_RS10550	COG0598	Magnesium transport protein CorA
SFLA_RS10585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SFLA_RS10590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SFLA_RS10600	COG1595	DNA-templated transcription, initiation
SFLA_RS10610	COG1024	Enoyl-CoA hydratase
SFLA_RS10615	COG0519	Catalyzes the synthesis of GMP from XMP
SFLA_RS10625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SFLA_RS10630	COG1611	Belongs to the LOG family
SFLA_RS10635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SFLA_RS10665	COG2912	Transglutaminase-like superfamily
SFLA_RS10690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SFLA_RS10710	COG4608	Belongs to the ABC transporter superfamily
SFLA_RS10720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS10725	COG0601	transmembrane transport
SFLA_RS10730	COG4166	transmembrane transport
SFLA_RS10735	COG4608	Belongs to the ABC transporter superfamily
SFLA_RS10740	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS10745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS10760	COG1217	gtp-binding protein TYPA
SFLA_RS10770	COG1335	isochorismatase
SFLA_RS10775	COG0477	Major facilitator Superfamily
SFLA_RS10795	COG1175	transmembrane transport
SFLA_RS10800	COG0395	ABC-type sugar transport system, permease component
SFLA_RS10820	COG1842	Phage shock protein A
SFLA_RS10870	COG3409	Peptidoglycan-binding domain 1 protein
SFLA_RS10905	COG0012	GTP binding
SFLA_RS10920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SFLA_RS10925	COG0531	amino acid
SFLA_RS10930	COG1570	exodeoxyribonuclease VII activity
SFLA_RS10935	COG1722	exodeoxyribonuclease VII activity
SFLA_RS10940	COG0778	Nitroreductase
SFLA_RS10965	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SFLA_RS10965	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SFLA_RS10970	COG0114	fumarate hydratase activity
SFLA_RS10985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SFLA_RS11020	COG0450	alkyl hydroperoxide reductase
SFLA_RS11025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SFLA_RS11040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SFLA_RS11045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SFLA_RS11050	COG0667	Aldo Keto reductase
SFLA_RS11065	COG2226	methyltransferase
SFLA_RS11085	COG3135	benzoate transporter
SFLA_RS11130	COG2885	chlorophyll binding
SFLA_RS11185	COG2894	cell division
SFLA_RS11215	COG2610	gluconate transmembrane transporter activity
SFLA_RS11220	COG0251	oxidation-reduction process
SFLA_RS11225	COG1414	Transcriptional regulator
SFLA_RS11240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SFLA_RS11265	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SFLA_RS11275	COG1331	Highly conserved protein containing a thioredoxin domain
SFLA_RS11285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SFLA_RS11320	COG2318	DinB family
SFLA_RS11345	COG2197	response regulator
SFLA_RS11355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SFLA_RS11365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SFLA_RS11380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SFLA_RS11405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SFLA_RS11410	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SFLA_RS11415	COG1396	sequence-specific DNA binding
SFLA_RS11420	COG2084	Dehydrogenase
SFLA_RS11430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SFLA_RS11435	COG1136	(ABC) transporter
SFLA_RS11445	COG1376	ErfK ybiS ycfS ynhG family protein
SFLA_RS11470	COG1024	Enoyl-CoA hydratase
SFLA_RS11485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SFLA_RS11495	COG0424	maF-like protein
SFLA_RS11505	COG4770	biotin carboxylase activity
SFLA_RS11540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SFLA_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS11560	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS11575	COG1595	DNA-templated transcription, initiation
SFLA_RS11580	COG0745	RESPONSE REGULATOR receiver
SFLA_RS11585	COG2205	protein histidine kinase activity
SFLA_RS11610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SFLA_RS11620	COG0583	DNA-binding transcription factor activity
SFLA_RS11625	COG2814	Major facilitator Superfamily
SFLA_RS11665	COG1079	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS11670	COG4603	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS11675	COG3845	ABC transporter
SFLA_RS11680	COG1744	ABC transporter substrate-binding protein PnrA-like
SFLA_RS11685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SFLA_RS11685	COG1473	amidohydrolase
SFLA_RS11695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SFLA_RS11695	COG0515	serine threonine protein kinase
SFLA_RS11705	COG2089	acid synthase
SFLA_RS11720	COG1216	Glycosyl transferase, family 2
SFLA_RS11730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SFLA_RS11745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS11745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS11755	COG1595	DNA-templated transcription, initiation
SFLA_RS11780	COG2009	succinate dehydrogenase
SFLA_RS11795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SFLA_RS11805	COG1309	transcriptional regulator
SFLA_RS11815	COG1408	metallophosphoesterase
SFLA_RS11830	COG1295	ribonuclease BN
SFLA_RS11850	COG0180	Tryptophanyl-tRNA synthetase
SFLA_RS11855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SFLA_RS11860	COG0754	glutathionylspermidine amidase activity
SFLA_RS11870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SFLA_RS11875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SFLA_RS11880	COG0039	L-malate dehydrogenase activity
SFLA_RS11895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SFLA_RS11910	COG0138	bifunctional purine biosynthesis protein purh
SFLA_RS11940	COG0045	succinate-CoA ligase (ADP-forming) activity
SFLA_RS11945	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SFLA_RS11950	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SFLA_RS11955	COG0714	Associated with various cellular activities
SFLA_RS11970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS11970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SFLA_RS12010	COG2197	response regulator
SFLA_RS12045	COG0519	Catalyzes the synthesis of GMP from XMP
SFLA_RS12045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SFLA_RS12070	COG0515	serine threonine protein kinase
SFLA_RS12085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SFLA_RS12100	COG0516	GMP reductase activity
SFLA_RS12110	COG1595	DNA-templated transcription, initiation
SFLA_RS12115	COG2197	response regulator
SFLA_RS12125	COG0583	DNA-binding transcription factor activity
SFLA_RS12130	COG2258	MOSC domain
SFLA_RS12135	COG4221	oxidoreductase activity
SFLA_RS12145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SFLA_RS12150	COG0726	polysaccharide deacetylase
SFLA_RS12175	COG4941	Belongs to the sigma-70 factor family
SFLA_RS12190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SFLA_RS12215	COG0802	atpase or kinase
SFLA_RS12225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SFLA_RS12240	COG0736	holo-[acyl-carrier-protein] synthase activity
SFLA_RS12245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SFLA_RS12255	COG1072	(Pantothenic acid kinase))
SFLA_RS12270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SFLA_RS12275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SFLA_RS12280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SFLA_RS12285	COG0488	(ABC) transporter
SFLA_RS12300	COG0101	tRNA pseudouridine synthase activity
SFLA_RS12305	COG0203	ribosomal protein L17
SFLA_RS12310	COG0202	RNA polymerase activity
SFLA_RS12315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SFLA_RS12320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SFLA_RS12325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SFLA_RS12330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SFLA_RS12340	COG0563	adenylate kinase activity
SFLA_RS12350	COG0200	Binds to the 23S rRNA
SFLA_RS12355	COG1841	ribosomal large subunit assembly
SFLA_RS12360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SFLA_RS12365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SFLA_RS12370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SFLA_RS12375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SFLA_RS12380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SFLA_RS12385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SFLA_RS12390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SFLA_RS12395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SFLA_RS12400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SFLA_RS12405	COG0255	Belongs to the universal ribosomal protein uL29 family
SFLA_RS12410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SFLA_RS12415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SFLA_RS12420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SFLA_RS12425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SFLA_RS12430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SFLA_RS12435	COG0089	rRNA binding
SFLA_RS12440	COG0088	Forms part of the polypeptide exit tunnel
SFLA_RS12445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SFLA_RS12450	COG0051	transcription antitermination factor activity, RNA binding
SFLA_RS12470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SFLA_RS12480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SFLA_RS12485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SFLA_RS12490	COG0049	tRNA binding
SFLA_RS12495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SFLA_RS12500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SFLA_RS12505	COG0085	RNA polymerase activity
SFLA_RS12510	COG0222	ribosome binding
SFLA_RS12515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SFLA_RS12520	COG0081	regulation of translation
SFLA_RS12525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SFLA_RS12545	COG0436	Aminotransferase
SFLA_RS12550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SFLA_RS12555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SFLA_RS12565	COG2030	dehydratase
SFLA_RS12570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SFLA_RS12590	COG0702	epimerase
SFLA_RS12595	COG2814	Major facilitator Superfamily
SFLA_RS12715	COG1666	GTP binding
SFLA_RS12720	COG2261	transglycosylase associated protein
SFLA_RS12725	COG3304	Inner membrane component domain
SFLA_RS12730	COG0501	Belongs to the peptidase M48B family
SFLA_RS12735	COG1970	mechanosensitive ion channel activity
SFLA_RS12740	COG1007	ATP synthesis coupled electron transport
SFLA_RS12755	COG0713	ATP synthesis coupled electron transport
SFLA_RS12760	COG0839	Belongs to the complex I subunit 6 family
SFLA_RS12765	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFLA_RS12770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SFLA_RS12775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFLA_RS12780	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFLA_RS12785	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFLA_RS12805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SFLA_RS12805	COG0674	pyruvate-flavodoxin oxidoreductase activity
SFLA_RS12810	COG1013	pyruvate-flavodoxin oxidoreductase activity
SFLA_RS12815	COG1733	regulation of RNA biosynthetic process
SFLA_RS12820	COG0702	epimerase
SFLA_RS12845	COG0561	phosphatase activity
SFLA_RS12850	COG1309	transcriptional regulator
SFLA_RS12870	COG0142	geranyltranstransferase activity
SFLA_RS12875	COG3104	oligopeptide transport
SFLA_RS12885	COG0179	Fumarylacetoacetate (FAA) hydrolase
SFLA_RS12900	COG0514	ATP-dependent DNA helicase (RecQ)
SFLA_RS12905	COG1007	ATP synthesis coupled electron transport
SFLA_RS12915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SFLA_RS12920	COG0713	ATP synthesis coupled electron transport
SFLA_RS12925	COG0839	Belongs to the complex I subunit 6 family
SFLA_RS12930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFLA_RS12935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SFLA_RS12940	COG1034	ATP synthesis coupled electron transport
SFLA_RS12945	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SFLA_RS12955	COG0649	NAD binding
SFLA_RS12960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFLA_RS12965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SFLA_RS12975	COG1388	LysM domain
SFLA_RS12975	COG0791	NLP P60 protein
SFLA_RS12975	COG3103	Sh3 type 3 domain protein
SFLA_RS12995	COG2226	methyltransferase
SFLA_RS13010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SFLA_RS13020	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SFLA_RS13025	COG1278	Cold shock
SFLA_RS13055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SFLA_RS13055	COG0515	serine threonine protein kinase
SFLA_RS13065	COG1309	transcriptional regulator
SFLA_RS13070	COG0259	pyridoxamine-phosphate oxidase activity
SFLA_RS13075	COG0501	Belongs to the peptidase M48B family
SFLA_RS13085	COG2072	flavoprotein involved in K transport
SFLA_RS13160	COG1131	(ABC) transporter
SFLA_RS13180	COG4821	SIS domain
SFLA_RS13200	COG0259	pyridoxamine-phosphate oxidase activity
SFLA_RS13245	COG1024	Enoyl-CoA hydratase
SFLA_RS13250	COG0318	PFAM AMP-dependent synthetase and ligase
SFLA_RS13265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SFLA_RS13285	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SFLA_RS13290	COG2318	DinB family
SFLA_RS13295	COG5006	permease, DMT superfamily
SFLA_RS13300	COG0583	DNA-binding transcription factor activity
SFLA_RS13305	COG0247	lactate metabolic process
SFLA_RS13305	COG0277	FAD linked oxidase domain protein
SFLA_RS13310	COG1316	TRANSCRIPTIONal
SFLA_RS13315	COG0642	Histidine kinase
SFLA_RS13345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SFLA_RS13375	COG1136	(ABC) transporter
SFLA_RS13410	COG0667	Aldo Keto reductase
SFLA_RS13440	COG4585	Histidine kinase
SFLA_RS13445	COG2197	response regulator
SFLA_RS13460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SFLA_RS13465	COG2267	carboxylic ester hydrolase activity
SFLA_RS13470	COG0667	Aldo Keto reductase
SFLA_RS13495	COG2252	PERMEase
SFLA_RS13505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SFLA_RS13530	COG2814	Major facilitator Superfamily
SFLA_RS13540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SFLA_RS13545	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SFLA_RS13550	COG1278	Cold shock
SFLA_RS13570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS13575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS13580	COG1120	ATPase activity
SFLA_RS13585	COG3226	Transcriptional regulator
SFLA_RS13590	COG0110	maltose O-acetyltransferase activity
SFLA_RS13610	COG1061	Type III restriction enzyme res subunit
SFLA_RS13620	COG3973	AAA domain
SFLA_RS13625	COG0531	amino acid
SFLA_RS13630	COG2409	Drug exporters of the RND superfamily
SFLA_RS13645	COG1984	allophanate hydrolase subunit 2
SFLA_RS13650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SFLA_RS13655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SFLA_RS13700	COG1737	Transcriptional regulator
SFLA_RS13705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SFLA_RS13770	COG0604	alcohol dehydrogenase
SFLA_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS13770	COG3321	synthase
SFLA_RS13785	COG2318	DinB family
SFLA_RS13810	COG0463	Glycosyl transferase, family 2
SFLA_RS13815	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SFLA_RS13820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SFLA_RS13820	COG1877	trehalose-phosphatase activity
SFLA_RS13855	COG5001	Diguanylate cyclase
SFLA_RS13855	COG3300	MHYT domain
SFLA_RS13865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SFLA_RS13885	COG4585	Histidine kinase
SFLA_RS13890	COG2197	response regulator
SFLA_RS13905	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SFLA_RS13920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SFLA_RS13945	COG3842	ATPase activity
SFLA_RS13965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SFLA_RS13970	COG0215	cysteine-tRNA ligase activity
SFLA_RS13995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SFLA_RS14000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SFLA_RS14005	COG1329	Transcriptional regulator
SFLA_RS14020	COG5002	protein histidine kinase activity
SFLA_RS14035	COG0588	phosphoglycerate mutase activity
SFLA_RS14060	COG1846	Transcriptional regulator
SFLA_RS14065	COG0697	spore germination
SFLA_RS14085	COG0438	transferase activity, transferring glycosyl groups
SFLA_RS14120	COG2318	DinB family
SFLA_RS14130	COG3467	pyridoxamine 5'-phosphate
SFLA_RS14165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SFLA_RS14170	COG4552	Acetyltransferase involved in intracellular survival and related
SFLA_RS14185	COG1490	D-aminoacyl-tRNA deacylase activity
SFLA_RS14200	COG3485	protocatechuate 3,4-dioxygenase
SFLA_RS14240	COG2897	thiosulfate sulfurtransferase activity
SFLA_RS14265	COG0745	RESPONSE REGULATOR receiver
SFLA_RS14270	COG1609	Transcriptional regulator
SFLA_RS14275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SFLA_RS14295	COG0823	Involved in the tonB-independent uptake of proteins
SFLA_RS14300	COG0737	Belongs to the 5'-nucleotidase family
SFLA_RS14310	COG0456	acetyltransferase
SFLA_RS14315	COG1725	Transcriptional regulator
SFLA_RS14320	COG1116	anion transmembrane transporter activity
SFLA_RS14340	COG0494	nUDIX hydrolase
SFLA_RS14340	COG0406	alpha-ribazole phosphatase activity
SFLA_RS14360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SFLA_RS14365	COG0306	phosphate transporter
SFLA_RS14375	COG1937	Protein conserved in bacteria
SFLA_RS14395	COG0671	phosphoesterase, PA-phosphatase related
SFLA_RS14400	COG0739	heme binding
SFLA_RS14400	COG0741	lytic transglycosylase activity
SFLA_RS14400	COG1196	nuclear chromosome segregation
SFLA_RS14465	COG0667	Aldo Keto reductase
SFLA_RS14535	COG1846	Transcriptional regulator
SFLA_RS14550	COG1252	NADH dehydrogenase
SFLA_RS14575	COG0579	oxidoreductase
SFLA_RS14580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SFLA_RS14595	COG0739	heme binding
SFLA_RS14595	COG0741	lytic transglycosylase activity
SFLA_RS14595	COG1196	nuclear chromosome segregation
SFLA_RS14625	COG1653	transport
SFLA_RS14790	COG0513	Belongs to the DEAD box helicase family
SFLA_RS14800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SFLA_RS14805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SFLA_RS14840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SFLA_RS14840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SFLA_RS14845	COG1643	Atp-dependent helicase
SFLA_RS14870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SFLA_RS14880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SFLA_RS14915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SFLA_RS14920	COG0047	phosphoribosylformylglycinamidine synthase activity
SFLA_RS14925	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SFLA_RS14955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SFLA_RS14970	COG0151	Belongs to the GarS family
SFLA_RS15035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFLA_RS15060	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SFLA_RS15075	COG3795	YCII-related domain
SFLA_RS15085	COG2234	aminopeptidase activity
SFLA_RS15100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SFLA_RS15130	COG0477	Major facilitator Superfamily
SFLA_RS15140	COG1191	sigma factor activity
SFLA_RS15145	COG1191	sigma factor activity
SFLA_RS15160	COG0477	Major facilitator Superfamily
SFLA_RS15165	COG2353	YceI-like domain
SFLA_RS15170	COG3467	pyridoxamine 5'-phosphate
SFLA_RS15185	COG0477	Major facilitator Superfamily
SFLA_RS15190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SFLA_RS15195	COG1215	transferase activity, transferring glycosyl groups
SFLA_RS15200	COG2205	protein histidine kinase activity
SFLA_RS15205	COG0745	RESPONSE REGULATOR receiver
SFLA_RS15235	COG1252	NADH dehydrogenase
SFLA_RS15260	COG0318	PFAM AMP-dependent synthetase and ligase
SFLA_RS15265	COG1595	DNA-templated transcription, initiation
SFLA_RS15375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SFLA_RS15390	COG0653	protein targeting
SFLA_RS15405	COG0006	proline dipeptidase activity
SFLA_RS15425	COG1999	signal sequence binding
SFLA_RS15435	COG2372	response to copper ion
SFLA_RS15440	COG2837	iron assimilation
SFLA_RS15450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SFLA_RS15455	COG0561	phosphatase activity
SFLA_RS15475	COG1131	(ABC) transporter
SFLA_RS15485	COG1131	(ABC) transporter
SFLA_RS15495	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SFLA_RS15510	COG0561	phosphatase activity
SFLA_RS15520	COG4988	ABC transporter
SFLA_RS15525	COG1294	oxidase, subunit
SFLA_RS15530	COG1271	oxidase subunit
SFLA_RS15535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SFLA_RS15540	COG1609	Transcriptional regulator
SFLA_RS15545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SFLA_RS15555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SFLA_RS15580	COG0662	Cupin 2, conserved barrel domain protein
SFLA_RS15585	COG1950	PFAM Membrane protein of
SFLA_RS15590	COG0626	cystathionine gamma-synthase activity
SFLA_RS15605	COG2814	Major facilitator Superfamily
SFLA_RS15630	COG0305	Participates in initiation and elongation during chromosome replication
SFLA_RS15640	COG0359	binds to the 23S rRNA
SFLA_RS15645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SFLA_RS15650	COG0629	single-stranded DNA binding
SFLA_RS15655	COG0360	Binds together with S18 to 16S ribosomal RNA
SFLA_RS15680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SFLA_RS15700	COG0617	tRNA 3'-terminal CCA addition
SFLA_RS15715	COG0515	serine threonine protein kinase
SFLA_RS15715	COG2815	serine threonine protein kinase
SFLA_RS15730	COG0492	ferredoxin-NADP+ reductase activity
SFLA_RS15735	COG3118	belongs to the thioredoxin family
SFLA_RS15750	COG1192	Involved in chromosome partitioning
SFLA_RS15755	COG0357	Ribosomal RNA small subunit methyltransferase G
SFLA_RS15765	COG0706	membrane insertase activity
SFLA_RS15775	COG0592	DNA-directed DNA polymerase activity
SFLA_RS15780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SFLA_RS15785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SFLA_RS15790	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SFLA_RS15800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SFLA_RS15825	COG0515	serine threonine protein kinase
SFLA_RS15850	COG0705	Rhomboid family
SFLA_RS15875	COG3764	Sortase (surface protein transpeptidase)
SFLA_RS15880	COG3764	Sortase (surface protein transpeptidase)
SFLA_RS15885	COG0515	serine threonine protein kinase
SFLA_RS15890	COG0768	penicillin binding
SFLA_RS15905	COG1716	ATPase activity
SFLA_RS15910	COG1716	ATPase activity
SFLA_RS15920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SFLA_RS15925	COG1733	regulation of RNA biosynthetic process
SFLA_RS15950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SFLA_RS15955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SFLA_RS15960	COG2151	metal-sulfur cluster biosynthetic enzyme
SFLA_RS15965	COG3396	Phenylacetate-CoA oxygenase
SFLA_RS15970	COG3460	Phenylacetate-CoA oxygenase
SFLA_RS15975	COG3396	Phenylacetate-CoA oxygenase
SFLA_RS16000	COG1309	transcriptional regulator
SFLA_RS16005	COG1522	sequence-specific DNA binding
SFLA_RS16030	COG0303	'Molybdopterin
SFLA_RS16035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SFLA_RS16040	COG3321	synthase
SFLA_RS16040	COG0604	alcohol dehydrogenase
SFLA_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS16055	COG0515	serine threonine protein kinase
SFLA_RS16060	COG0515	serine threonine protein kinase
SFLA_RS16085	COG0022	dehydrogenase e1 component
SFLA_RS16090	COG0508	dehydrogenase complex catalyzes the overall conversion of
SFLA_RS16115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SFLA_RS16135	COG3629	intracellular signal transduction
SFLA_RS16135	COG3903	Transcriptional regulator
SFLA_RS16145	COG1362	aminopeptidase activity
SFLA_RS16150	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS16160	COG1741	Belongs to the pirin family
SFLA_RS16165	COG0628	permease
SFLA_RS16175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SFLA_RS16190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SFLA_RS16195	COG0745	RESPONSE REGULATOR receiver
SFLA_RS16200	COG2205	protein histidine kinase activity
SFLA_RS16225	COG0604	alcohol dehydrogenase
SFLA_RS16250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS16255	COG0180	Tryptophanyl-tRNA synthetase
SFLA_RS16265	COG2255	four-way junction helicase activity
SFLA_RS16300	COG0475	glutathione-regulated potassium exporter activity
SFLA_RS16305	COG0490	domain, Protein
SFLA_RS16315	COG2268	Band 7 protein
SFLA_RS16320	COG1585	Membrane protein implicated in regulation of membrane protease activity
SFLA_RS16360	COG1278	Cold shock
SFLA_RS16365	COG0513	Belongs to the DEAD box helicase family
SFLA_RS16375	COG3594	Acyltransferase
SFLA_RS16395	COG1309	transcriptional regulator
SFLA_RS16415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SFLA_RS16430	COG0488	(ABC) transporter
SFLA_RS16460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SFLA_RS16500	COG0717	Belongs to the dCTP deaminase family
SFLA_RS16505	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SFLA_RS16515	COG0247	lactate metabolic process
SFLA_RS16515	COG2181	nitrate reductase activity
SFLA_RS16520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SFLA_RS16525	COG0443	Heat shock 70 kDa protein
SFLA_RS16530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SFLA_RS16535	COG0484	heat shock protein binding
SFLA_RS16540	COG0789	Transcriptional regulator
SFLA_RS16570	COG0542	response to heat
SFLA_RS16600	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SFLA_RS16615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SFLA_RS16620	COG0191	fructose-bisphosphate aldolase activity
SFLA_RS16625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SFLA_RS16630	COG0477	Major facilitator Superfamily
SFLA_RS16640	COG3483	tryptophan 2,3-dioxygenase activity
SFLA_RS16645	COG3844	kynureninase activity
SFLA_RS16655	COG4585	Histidine kinase
SFLA_RS16660	COG2197	response regulator
SFLA_RS16665	COG2124	cytochrome p450
SFLA_RS16670	COG3559	Exporter of polyketide antibiotics
SFLA_RS16675	COG1131	(ABC) transporter
SFLA_RS16690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SFLA_RS16715	COG0592	DNA-directed DNA polymerase activity
SFLA_RS16730	COG0693	protein deglycase activity
SFLA_RS16735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SFLA_RS16740	COG1802	Transcriptional regulator
SFLA_RS16755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SFLA_RS16760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SFLA_RS16780	COG1595	DNA-templated transcription, initiation
SFLA_RS16810	COG2755	lipolytic protein G-D-S-L family
SFLA_RS16815	COG0326	Molecular chaperone. Has ATPase activity
SFLA_RS16825	COG1309	transcriptional regulator
SFLA_RS16840	COG2828	Protein conserved in bacteria
SFLA_RS16850	COG1408	metallophosphoesterase
SFLA_RS16855	COG1610	YqeY-like protein
SFLA_RS16860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SFLA_RS16870	COG0003	Pfam Anion-transporting ATPase
SFLA_RS16890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SFLA_RS16915	COG2267	carboxylic ester hydrolase activity
SFLA_RS16925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SFLA_RS16930	COG2826	transposase and inactivated derivatives, IS30 family
SFLA_RS16935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SFLA_RS16940	COG0288	reversible hydration of carbon dioxide
SFLA_RS16995	COG1205	dead DEAH box helicase
SFLA_RS16995	COG1111	helicase
SFLA_RS17000	COG1366	Belongs to the anti-sigma-factor antagonist family
SFLA_RS17010	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SFLA_RS17020	COG2890	protein-(glutamine-N5) methyltransferase activity
SFLA_RS17030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SFLA_RS17030	COG1754	DNA topoisomerase type I activity
SFLA_RS17035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SFLA_RS17040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SFLA_RS17055	COG1335	isochorismatase
SFLA_RS17065	COG2897	thiosulfate sulfurtransferase activity
SFLA_RS17085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SFLA_RS17085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SFLA_RS17120	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS17125	COG2318	DinB family
SFLA_RS17145	COG0076	glutamate decarboxylase activity
SFLA_RS17150	COG0655	NAD(P)H dehydrogenase (quinone) activity
SFLA_RS17155	COG0393	Putative heavy-metal-binding
SFLA_RS17170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SFLA_RS17175	COG2027	D-alanyl-D-alanine carboxypeptidase
SFLA_RS17185	COG0037	tRNA processing
SFLA_RS17200	COG0302	gtp cyclohydrolase
SFLA_RS17220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SFLA_RS17235	COG0517	IMP dehydrogenase activity
SFLA_RS17235	COG1125	glycine betaine transport
SFLA_RS17240	COG1174	glycine betaine transport
SFLA_RS17245	COG1174	glycine betaine transport
SFLA_RS17260	COG0649	NAD binding
SFLA_RS17275	COG2197	response regulator
SFLA_RS17290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SFLA_RS17295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SFLA_RS17305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SFLA_RS17325	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SFLA_RS17345	COG0739	heme binding
SFLA_RS17355	COG0477	Major facilitator Superfamily
SFLA_RS17360	COG2205	protein histidine kinase activity
SFLA_RS17365	COG0745	RESPONSE REGULATOR receiver
SFLA_RS17375	COG1595	DNA-templated transcription, initiation
SFLA_RS17380	COG1194	a g-specific adenine glycosylase
SFLA_RS17390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS17445	COG0667	Aldo Keto reductase
SFLA_RS17450	COG2826	transposase and inactivated derivatives, IS30 family
SFLA_RS17455	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SFLA_RS17475	COG0248	Ppx GppA phosphatase
SFLA_RS17480	COG1082	Xylose isomerase domain protein TIM barrel
SFLA_RS17495	COG0129	dihydroxy-acid dehydratase activity
SFLA_RS17500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SFLA_RS17500	COG0515	serine threonine protein kinase
SFLA_RS17520	COG1129	ABC transporter
SFLA_RS17520	COG0842	Transport permease protein
SFLA_RS17530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SFLA_RS17560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SFLA_RS17565	COG2223	nitrite transmembrane transporter activity
SFLA_RS17570	COG0123	including yeast histone deacetylase and acetoin utilization protein
SFLA_RS17615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SFLA_RS17620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SFLA_RS17625	COG0181	hydroxymethylbilane synthase activity
SFLA_RS17630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SFLA_RS17630	COG1648	precorrin-2 dehydrogenase activity
SFLA_RS17640	COG0113	porphobilinogen synthase activity
SFLA_RS17665	COG2197	response regulator
SFLA_RS17670	COG4585	Histidine kinase
SFLA_RS17710	COG1595	DNA-templated transcription, initiation
SFLA_RS17720	COG0018	arginyl-trna synthetase
SFLA_RS17725	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SFLA_RS17745	COG1690	Belongs to the RtcB family
SFLA_RS17760	COG1742	UPF0060 membrane protein
SFLA_RS17790	COG0659	secondary active sulfate transmembrane transporter activity
SFLA_RS17795	COG2208	phosphoserine phosphatase activity
SFLA_RS17795	COG2770	Histidine kinase
SFLA_RS17830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SFLA_RS17835	COG0406	alpha-ribazole phosphatase activity
SFLA_RS17845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SFLA_RS17850	COG0785	Cytochrome C biogenesis protein
SFLA_RS17855	COG1333	cytochrome c biogenesis protein
SFLA_RS17860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SFLA_RS17865	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS17885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SFLA_RS17890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SFLA_RS17900	COG0163	prenyltransferase activity
SFLA_RS17910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SFLA_RS17925	COG1301	dicarboxylic acid transport
SFLA_RS17935	COG1309	transcriptional regulator
SFLA_RS17945	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS17965	COG0768	penicillin binding
SFLA_RS17980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SFLA_RS17990	COG2084	Dehydrogenase
SFLA_RS17995	COG1082	Xylose isomerase domain protein TIM barrel
SFLA_RS18000	COG0149	triose-phosphate isomerase activity
SFLA_RS18005	COG0698	ribose 5-phosphate isomerase
SFLA_RS18010	COG2376	Dihydroxyacetone kinase
SFLA_RS18020	COG2186	Transcriptional regulator
SFLA_RS18030	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SFLA_RS18035	COG0789	Transcriptional regulator
SFLA_RS18040	COG1902	pentaerythritol trinitrate reductase activity
SFLA_RS18045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SFLA_RS18085	COG1686	Belongs to the peptidase S11 family
SFLA_RS18120	COG2378	regulation of single-species biofilm formation
SFLA_RS18160	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SFLA_RS18165	COG2188	Transcriptional regulator
SFLA_RS18240	COG0582	viral genome integration into host DNA
SFLA_RS18270	COG1846	Transcriptional regulator
SFLA_RS18275	COG3384	dioxygenase
SFLA_RS18280	COG1247	-acetyltransferase
SFLA_RS18305	COG0243	molybdopterin cofactor binding
SFLA_RS18310	COG0437	4 iron, 4 sulfur cluster binding
SFLA_RS18330	COG1970	mechanosensitive ion channel activity
SFLA_RS18340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SFLA_RS18365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SFLA_RS18370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SFLA_RS18380	COG0315	cyclic pyranopterin monophosphate synthase activity
SFLA_RS18385	COG0521	Mo-molybdopterin cofactor biosynthetic process
SFLA_RS18445	COG2072	flavoprotein involved in K transport
SFLA_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS18465	COG4946	Tricorn protease homolog
SFLA_RS18465	COG0793	Belongs to the peptidase S41A family
SFLA_RS18475	COG2409	Drug exporters of the RND superfamily
SFLA_RS18485	COG0310	cobalt ion transport
SFLA_RS18495	COG1122	ATPase activity
SFLA_RS18500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SFLA_RS18510	COG0456	acetyltransferase
SFLA_RS18510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SFLA_RS18530	COG0442	prolyl-tRNA aminoacylation
SFLA_RS18540	COG1079	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS18545	COG4603	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS18550	COG3845	ABC transporter
SFLA_RS18585	COG0084	hydrolase, TatD family'
SFLA_RS18595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SFLA_RS18600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SFLA_RS18610	COG4115	mRNA cleavage
SFLA_RS18615	COG2161	toxin-antitoxin pair type II binding
SFLA_RS18625	COG0488	(ABC) transporter
SFLA_RS18655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SFLA_RS18670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SFLA_RS18680	COG2197	response regulator
SFLA_RS18685	COG1846	Transcriptional regulator
SFLA_RS18690	COG4106	trans-aconitate 2-methyltransferase activity
SFLA_RS18700	COG1309	transcriptional regulator
SFLA_RS18710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SFLA_RS18720	COG0193	aminoacyl-tRNA hydrolase activity
SFLA_RS18725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SFLA_RS18730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SFLA_RS18735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SFLA_RS18750	COG4585	Histidine kinase
SFLA_RS18780	COG1366	Belongs to the anti-sigma-factor antagonist family
SFLA_RS18790	COG0596	Alpha beta hydrolase
SFLA_RS18795	COG0477	Major facilitator Superfamily
SFLA_RS18800	COG1136	(ABC) transporter
SFLA_RS18800	COG0577	efflux transmembrane transporter activity
SFLA_RS18805	COG0577	efflux transmembrane transporter activity
SFLA_RS18845	COG2815	serine threonine protein kinase
SFLA_RS18845	COG0515	serine threonine protein kinase
SFLA_RS18860	COG2124	cytochrome p450
SFLA_RS18875	COG0148	phosphopyruvate hydratase activity
SFLA_RS18895	COG1252	NADH dehydrogenase
SFLA_RS18900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SFLA_RS18905	COG1136	(ABC) transporter
SFLA_RS18905	COG0577	efflux transmembrane transporter activity
SFLA_RS18910	COG1136	(ABC) transporter
SFLA_RS18915	COG1609	Transcriptional regulator
SFLA_RS18925	COG0601	transmembrane transport
SFLA_RS18935	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS18940	COG4608	Belongs to the ABC transporter superfamily
SFLA_RS18985	COG0183	Belongs to the thiolase family
SFLA_RS18990	COG2755	lipolytic protein G-D-S-L family
SFLA_RS19045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SFLA_RS19050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SFLA_RS19060	COG1228	amidohydrolase
SFLA_RS19070	COG1191	sigma factor activity
SFLA_RS19075	COG1366	Belongs to the anti-sigma-factor antagonist family
SFLA_RS19085	COG3104	oligopeptide transport
SFLA_RS19090	COG0745	RESPONSE REGULATOR receiver
SFLA_RS19095	COG2205	protein histidine kinase activity
SFLA_RS19120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SFLA_RS19150	COG1316	TRANSCRIPTIONal
SFLA_RS19155	COG1607	acyl-coa hydrolase
SFLA_RS19165	COG1473	amidohydrolase
SFLA_RS19170	COG0477	Major facilitator Superfamily
SFLA_RS19175	COG1316	TRANSCRIPTIONal
SFLA_RS19190	COG1316	TRANSCRIPTIONal
SFLA_RS19195	COG1316	TRANSCRIPTIONal
SFLA_RS19220	COG0778	Nitroreductase
SFLA_RS19220	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SFLA_RS19225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SFLA_RS19260	COG1620	l-lactate permease
SFLA_RS19270	COG2835	tetraacyldisaccharide 4'-kinase activity
SFLA_RS19280	COG1482	cell wall glycoprotein biosynthetic process
SFLA_RS19290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SFLA_RS19330	COG0714	Associated with various cellular activities
SFLA_RS19350	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SFLA_RS19355	COG0745	RESPONSE REGULATOR receiver
SFLA_RS19360	COG5002	protein histidine kinase activity
SFLA_RS19360	COG5000	phosphorelay sensor kinase activity
SFLA_RS19365	COG0823	Involved in the tonB-independent uptake of proteins
SFLA_RS19375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SFLA_RS19380	COG2197	response regulator
SFLA_RS19395	COG0653	protein targeting
SFLA_RS19415	COG2902	Dehydrogenase
SFLA_RS19420	COG1134	teichoic acid transport
SFLA_RS19430	COG1309	transcriptional regulator
SFLA_RS19435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SFLA_RS19440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SFLA_RS19445	COG2226	methyltransferase
SFLA_RS19445	COG1073	alpha beta
SFLA_RS19455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SFLA_RS19460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SFLA_RS19465	COG0438	transferase activity, transferring glycosyl groups
SFLA_RS19470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SFLA_RS19470	COG0463	Glycosyl transferase, family 2
SFLA_RS19475	COG0395	ABC-type sugar transport system, permease component
SFLA_RS19480	COG1175	transmembrane transport
SFLA_RS19485	COG1653	transport
SFLA_RS19490	COG1674	ftsk spoiiie
SFLA_RS19495	COG0515	serine threonine protein kinase
SFLA_RS19500	COG0515	serine threonine protein kinase
SFLA_RS19505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SFLA_RS19520	COG2884	Cell division ATP-binding protein ftsE
SFLA_RS19525	COG2177	Part of the ABC transporter FtsEX involved in
SFLA_RS19530	COG0793	Belongs to the peptidase S41A family
SFLA_RS19535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SFLA_RS19545	COG0583	DNA-binding transcription factor activity
SFLA_RS19565	COG2223	nitrite transmembrane transporter activity
SFLA_RS19595	COG3973	AAA domain
SFLA_RS19595	COG3973	AAA domain
SFLA_RS19605	COG0776	regulation of translation
SFLA_RS19610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SFLA_RS19615	COG1678	Uncharacterized ACR, COG1678
SFLA_RS19635	COG0395	ABC-type sugar transport system, permease component
SFLA_RS19640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SFLA_RS19715	COG1174	glycine betaine transport
SFLA_RS19725	COG1174	glycine betaine transport
SFLA_RS19735	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SFLA_RS19745	COG0277	FAD linked oxidase domain protein
SFLA_RS19780	COG1335	isochorismatase
SFLA_RS19790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SFLA_RS19800	COG1113	amino acid transport
SFLA_RS19825	COG1234	tRNA 3'-trailer cleavage
SFLA_RS19830	COG2826	transposase and inactivated derivatives, IS30 family
SFLA_RS19835	COG1263	PTS System
SFLA_RS19840	COG1263	PTS System
SFLA_RS19845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SFLA_RS19850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SFLA_RS19860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SFLA_RS19875	COG0477	Major facilitator Superfamily
SFLA_RS19900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SFLA_RS19930	COG2733	membrane
SFLA_RS19940	COG0137	argininosuccinate synthase activity
SFLA_RS19945	COG1349	DNA-binding transcription factor activity
SFLA_RS19965	COG1396	sequence-specific DNA binding
SFLA_RS19970	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS19980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SFLA_RS20020	COG3708	Transcriptional regulator
SFLA_RS20020	COG2207	Transcriptional regulator
SFLA_RS20040	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SFLA_RS20075	COG2362	D-Aminopeptidase
SFLA_RS20100	COG0477	Major facilitator Superfamily
SFLA_RS20140	COG0706	membrane insertase activity
SFLA_RS20140	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
SFLA_RS20145	COG0179	Fumarylacetoacetate (FAA) hydrolase
SFLA_RS20150	COG4702	Belongs to the UPF0303 family
SFLA_RS20155	COG0673	inositol 2-dehydrogenase activity
SFLA_RS20200	COG3397	chitin binding
SFLA_RS20215	COG1126	abc transporter atp-binding protein
SFLA_RS20220	COG0765	amino acid transport
SFLA_RS20225	COG0765	amino acid transport
SFLA_RS20230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFLA_RS20250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS20315	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SFLA_RS20325	COG0745	RESPONSE REGULATOR receiver
SFLA_RS20350	COG0395	ABC-type sugar transport system, permease component
SFLA_RS20385	COG4977	sequence-specific DNA binding
SFLA_RS20390	COG0589	response to stress
SFLA_RS20395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SFLA_RS20415	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SFLA_RS20435	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS20450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SFLA_RS20455	COG1309	transcriptional regulator
SFLA_RS20480	COG1946	Acyl-CoA thioesterase
SFLA_RS20505	COG1874	Beta-galactosidase
SFLA_RS20510	COG1609	Transcriptional regulator
SFLA_RS20515	COG0395	ABC-type sugar transport system, permease component
SFLA_RS20520	COG1175	transmembrane transport
SFLA_RS20580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SFLA_RS20590	COG0028	Belongs to the TPP enzyme family
SFLA_RS20625	COG1472	Belongs to the glycosyl hydrolase 3 family
SFLA_RS20650	COG1404	Belongs to the peptidase S8 family
SFLA_RS20680	COG0515	serine threonine protein kinase
SFLA_RS20705	COG1609	Transcriptional regulator
SFLA_RS20710	COG0673	inositol 2-dehydrogenase activity
SFLA_RS20720	COG1082	Xylose isomerase domain protein TIM barrel
SFLA_RS20720	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SFLA_RS20745	COG0500	methyltransferase
SFLA_RS20755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SFLA_RS20780	COG2409	Drug exporters of the RND superfamily
SFLA_RS20805	COG3718	enzyme involved in inositol metabolism
SFLA_RS20810	COG3962	Belongs to the TPP enzyme family
SFLA_RS20845	COG3254	rhamnose metabolic process
SFLA_RS20850	COG1879	ABC-type sugar transport system periplasmic component
SFLA_RS20855	COG1172	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS20865	COG1129	ABC transporter
SFLA_RS20900	COG0629	single-stranded DNA binding
SFLA_RS20925	COG1136	(ABC) transporter
SFLA_RS20925	COG0577	efflux transmembrane transporter activity
SFLA_RS20940	COG2346	COG2346, Truncated hemoglobins
SFLA_RS20990	COG1486	melibiose metabolic process
SFLA_RS20995	COG0395	ABC-type sugar transport system, permease component
SFLA_RS21000	COG1175	transmembrane transport
SFLA_RS21005	COG1653	transport
SFLA_RS21010	COG1846	Transcriptional regulator
SFLA_RS21010	COG1940	carbohydrate kinase activity
SFLA_RS21015	COG0668	transmembrane transport
SFLA_RS21025	COG3291	Pkd domain containing protein
SFLA_RS21025	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SFLA_RS21050	COG4266	Belongs to the allantoicase family
SFLA_RS21085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SFLA_RS21095	COG2211	Major facilitator Superfamily
SFLA_RS21105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SFLA_RS21110	COG0456	acetyltransferase
SFLA_RS21120	COG1113	amino acid transport
SFLA_RS21125	COG1113	amino acid transport
SFLA_RS21140	COG1113	amino acid transport
SFLA_RS21155	COG4552	Acetyltransferase involved in intracellular survival and related
SFLA_RS21165	COG0475	glutathione-regulated potassium exporter activity
SFLA_RS21175	COG3594	Acyltransferase
SFLA_RS21200	COG0544	peptidyl-prolyl cis-trans isomerase activity
SFLA_RS21205	COG0740	serine-type endopeptidase activity
SFLA_RS21210	COG0740	serine-type endopeptidase activity
SFLA_RS21215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SFLA_RS21220	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SFLA_RS21235	COG0525	valine-tRNA ligase activity
SFLA_RS21240	COG0285	dihydrofolate synthase activity
SFLA_RS21250	COG0105	UTP biosynthetic process
SFLA_RS21255	COG1077	Cell shape determining protein MreB Mrl
SFLA_RS21275	COG0772	Belongs to the SEDS family
SFLA_RS21295	COG1530	ribonuclease E activity
SFLA_RS21300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SFLA_RS21305	COG0673	inositol 2-dehydrogenase activity
SFLA_RS21355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SFLA_RS21360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SFLA_RS21365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SFLA_RS21390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SFLA_RS21400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SFLA_RS21415	COG0501	Belongs to the peptidase M48B family
SFLA_RS21430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SFLA_RS21440	COG0799	negative regulation of ribosome biogenesis
SFLA_RS21445	COG0588	phosphoglycerate mutase activity
SFLA_RS21465	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SFLA_RS21475	COG0495	leucyl-tRNA aminoacylation
SFLA_RS21485	COG1307	EDD domain protein, DegV family
SFLA_RS21490	COG1555	photosystem II stabilization
SFLA_RS21505	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SFLA_RS21525	COG0268	Binds directly to 16S ribosomal RNA
SFLA_RS21530	COG0481	GTPase activity
SFLA_RS21565	COG1420	regulation of RNA biosynthetic process
SFLA_RS21570	COG0484	heat shock protein binding
SFLA_RS21585	COG0537	adenosine 5'-monophosphoramidase activity
SFLA_RS21590	COG1234	tRNA 3'-trailer cleavage
SFLA_RS21595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SFLA_RS21605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SFLA_RS21615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SFLA_RS21625	COG2315	Protein conserved in bacteria
SFLA_RS21635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SFLA_RS21650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SFLA_RS21660	COG1381	Involved in DNA repair and RecF pathway recombination
SFLA_RS21665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SFLA_RS21675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SFLA_RS21680	COG1121	(ABC) transporter
SFLA_RS21690	COG0423	glycine-tRNA ligase activity
SFLA_RS21705	COG0477	Major facilitator Superfamily
SFLA_RS21720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SFLA_RS21720	COG0574	Belongs to the PEP-utilizing enzyme family
SFLA_RS21745	COG2146	nitrite reductase [NAD(P)H] activity
SFLA_RS21745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFLA_RS21750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFLA_RS21750	COG2146	nitrite reductase [NAD(P)H] activity
SFLA_RS21755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SFLA_RS21785	COG0431	NADPH-dependent FMN reductase
SFLA_RS21800	COG0243	molybdopterin cofactor binding
SFLA_RS21805	COG2949	membrane
SFLA_RS21815	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SFLA_RS21825	COG0358	DNA primase activity
SFLA_RS21830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SFLA_RS21845	COG1070	Carbohydrate kinase
SFLA_RS21875	COG1404	Belongs to the peptidase S8 family
SFLA_RS21915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS21925	COG3903	Transcriptional regulator
SFLA_RS21925	COG3629	intracellular signal transduction
SFLA_RS21935	COG0825	malonyl-CoA metabolic process
SFLA_RS21935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SFLA_RS21940	COG0318	PFAM AMP-dependent synthetase and ligase
SFLA_RS21950	COG1522	sequence-specific DNA binding
SFLA_RS21980	COG2130	NADP-dependent
SFLA_RS21990	COG1764	response to oxidative stress
SFLA_RS22005	COG4214	carbohydrate transport
SFLA_RS22015	COG4213	ABC transporter substrate-binding protein
SFLA_RS22055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SFLA_RS22060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SFLA_RS22065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SFLA_RS22080	COG1741	Belongs to the pirin family
SFLA_RS22085	COG1733	regulation of RNA biosynthetic process
SFLA_RS22130	COG0789	Transcriptional regulator
SFLA_RS22135	COG0667	Aldo Keto reductase
SFLA_RS22150	COG2197	response regulator
SFLA_RS22155	COG4585	Histidine kinase
SFLA_RS22170	COG1309	transcriptional regulator
SFLA_RS22175	COG0477	Major facilitator Superfamily
SFLA_RS22185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SFLA_RS22230	COG1358	cellular component organization or biogenesis
SFLA_RS22290	COG0494	nUDIX hydrolase
SFLA_RS22395	COG3845	ABC transporter
SFLA_RS22410	COG1657	PFAM Prenyltransferase squalene oxidase
SFLA_RS22425	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS22445	COG0559	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS22465	COG1309	transcriptional regulator
SFLA_RS22470	COG0438	transferase activity, transferring glycosyl groups
SFLA_RS22520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SFLA_RS22525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SFLA_RS22540	COG0800	Aldolase
SFLA_RS22545	COG3022	response to hydroperoxide
SFLA_RS22585	COG2124	cytochrome p450
SFLA_RS22615	COG1309	transcriptional regulator
SFLA_RS22620	COG0667	Aldo Keto reductase
SFLA_RS22640	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS22645	COG3540	Alkaline phosphatase
SFLA_RS22655	COG2814	Major facilitator Superfamily
SFLA_RS22670	COG1834	amidinotransferase
SFLA_RS22690	COG0672	)-iron permease
SFLA_RS22695	COG2837	iron assimilation
SFLA_RS22705	COG1120	ATPase activity
SFLA_RS22710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS22715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SFLA_RS22775	COG1994	Peptidase M50
SFLA_RS22795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SFLA_RS22800	COG0477	Major facilitator Superfamily
SFLA_RS22805	COG1309	transcriptional regulator
SFLA_RS22820	COG2814	Major facilitator Superfamily
SFLA_RS22830	COG1595	DNA-templated transcription, initiation
SFLA_RS22835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SFLA_RS22835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SFLA_RS22840	COG2132	Multicopper oxidase
SFLA_RS22860	COG0174	glutamine synthetase
SFLA_RS22865	COG0738	Major facilitator superfamily
SFLA_RS22870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SFLA_RS22875	COG2890	protein-(glutamine-N5) methyltransferase activity
SFLA_RS22880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SFLA_RS22890	COG1609	Transcriptional regulator
SFLA_RS22905	COG0395	ABC-type sugar transport system, permease component
SFLA_RS22910	COG0366	Alpha amylase catalytic
SFLA_RS22930	COG0789	Transcriptional regulator
SFLA_RS23000	COG2197	response regulator
SFLA_RS23005	COG4585	Histidine kinase
SFLA_RS23010	COG0745	RESPONSE REGULATOR receiver
SFLA_RS23080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SFLA_RS23085	COG0321	lipoyl(octanoyl) transferase activity
SFLA_RS23120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SFLA_RS23130	COG0508	dehydrogenase complex catalyzes the overall conversion of
SFLA_RS23135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SFLA_RS23140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SFLA_RS23145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SFLA_RS23155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SFLA_RS23170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SFLA_RS23175	COG4106	trans-aconitate 2-methyltransferase activity
SFLA_RS23195	COG4585	Histidine kinase
SFLA_RS23200	COG2197	response regulator
SFLA_RS23205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SFLA_RS23210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SFLA_RS23230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SFLA_RS23240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SFLA_RS23245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SFLA_RS23255	COG1376	ErfK ybiS ycfS ynhG family protein
SFLA_RS23265	COG1845	cytochrome c oxidase, subunit III
SFLA_RS23270	COG2010	Cytochrome c
SFLA_RS23275	COG0723	plastoquinol--plastocyanin reductase activity
SFLA_RS23280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SFLA_RS23285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SFLA_RS23290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SFLA_RS23355	COG0003	Pfam Anion-transporting ATPase
SFLA_RS23365	COG1940	carbohydrate kinase activity
SFLA_RS23395	COG2197	response regulator
SFLA_RS23400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SFLA_RS23410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SFLA_RS23420	COG2193	ferroxidase activity
SFLA_RS23425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SFLA_RS23430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SFLA_RS23435	COG0515	serine threonine protein kinase
SFLA_RS23435	COG2815	serine threonine protein kinase
SFLA_RS23440	COG2022	thiamine diphosphate biosynthetic process
SFLA_RS23450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SFLA_RS23450	COG2022	thiamine diphosphate biosynthetic process
SFLA_RS23470	COG0352	thiamine-phosphate diphosphorylase activity
SFLA_RS23485	COG1233	COG1233 Phytoene dehydrogenase and related
SFLA_RS23500	COG1511	domain protein
SFLA_RS23505	COG1121	(ABC) transporter
SFLA_RS23515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SFLA_RS23535	COG0714	Associated with various cellular activities
SFLA_RS23545	COG0275	rRNA processing
SFLA_RS23555	COG0768	penicillin binding
SFLA_RS23560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SFLA_RS23570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SFLA_RS23575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SFLA_RS23585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SFLA_RS23590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SFLA_RS23605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SFLA_RS23610	COG1799	cell septum assembly
SFLA_RS23620	COG3599	regulation of cell shape
SFLA_RS23625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SFLA_RS23635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SFLA_RS23645	COG2153	protein acetylation
SFLA_RS23685	COG0587	DNA-directed DNA polymerase activity
SFLA_RS23690	COG1432	Conserved Protein
SFLA_RS23710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SFLA_RS23735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SFLA_RS23740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SFLA_RS23745	COG0131	Imidazoleglycerol-phosphate dehydratase
SFLA_RS23755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SFLA_RS23760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SFLA_RS23765	COG0251	oxidation-reduction process
SFLA_RS23770	COG0107	imidazoleglycerol-phosphate synthase activity
SFLA_RS23780	COG2755	lipolytic protein G-D-S-L family
SFLA_RS23800	COG2508	Transcriptional regulator
SFLA_RS23805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SFLA_RS23815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SFLA_RS23840	COG0134	indole-3-glycerol-phosphate synthase activity
SFLA_RS23845	COG0133	tryptophan synthase activity
SFLA_RS23850	COG0159	tryptophan synthase activity
SFLA_RS23860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SFLA_RS23865	COG2301	Belongs to the HpcH HpaI aldolase family
SFLA_RS23870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SFLA_RS23875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SFLA_RS23905	COG0070	glutamate synthase
SFLA_RS23905	COG0069	glutamate synthase activity
SFLA_RS23905	COG0067	glutamate synthase
SFLA_RS23915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SFLA_RS23920	COG0705	Rhomboid family
SFLA_RS23930	COG1309	transcriptional regulator
SFLA_RS23935	COG1278	Cold shock
SFLA_RS23960	COG0287	Prephenate dehydrogenase
SFLA_RS23960	COG1605	Chorismate mutase
SFLA_RS23980	COG0737	Belongs to the 5'-nucleotidase family
SFLA_RS24010	COG0411	ABC transporter
SFLA_RS24030	COG2050	protein possibly involved in aromatic compounds catabolism
SFLA_RS24055	COG1643	Atp-dependent helicase
SFLA_RS24060	COG2226	methyltransferase
SFLA_RS24075	COG0237	dephospho-CoA kinase activity
SFLA_RS24105	COG0330	HflC and HflK could
SFLA_RS24110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SFLA_RS24135	COG0436	Aminotransferase
SFLA_RS24155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SFLA_RS24160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SFLA_RS24170	COG0831	urea catabolic process
SFLA_RS24180	COG0832	Belongs to the urease beta subunit family
SFLA_RS24185	COG0804	urea catabolic process
SFLA_RS24195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SFLA_RS24200	COG0829	nickel cation binding
SFLA_RS24220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SFLA_RS24225	COG0584	glycerophosphoryl diester phosphodiesterase
SFLA_RS24235	COG0556	nucleotide-excision repair
SFLA_RS24265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SFLA_RS24275	COG0322	excinuclease ABC activity
SFLA_RS24280	COG1660	Displays ATPase and GTPase activities
SFLA_RS24285	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SFLA_RS24290	COG1481	regulation of sporulation
SFLA_RS24295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SFLA_RS24300	COG0126	phosphoglycerate kinase activity
SFLA_RS24305	COG0149	triose-phosphate isomerase activity
SFLA_RS24310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SFLA_RS24320	COG0166	Belongs to the GPI family
SFLA_RS24335	COG0363	glucosamine-6-phosphate deaminase activity
SFLA_RS24350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SFLA_RS24360	COG0109	protoheme IX farnesyltransferase activity
SFLA_RS24395	COG0719	Fe-S assembly protein
SFLA_RS24405	COG0396	ATPase activity
SFLA_RS24410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SFLA_RS24415	COG0822	iron-sulfur transferase activity
SFLA_RS24435	COG2076	Multidrug Resistance protein
SFLA_RS24440	COG3226	Transcriptional regulator
SFLA_RS24445	COG2171	N-acyltransferase activity
SFLA_RS24450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SFLA_RS24490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SFLA_RS24495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SFLA_RS24505	COG1802	Transcriptional regulator
SFLA_RS24525	COG0395	ABC-type sugar transport system, permease component
SFLA_RS24550	COG2755	lipolytic protein G-D-S-L family
SFLA_RS24555	COG3866	Pectate lyase
SFLA_RS24560	COG4677	pectinesterase activity
SFLA_RS24585	COG2252	PERMEase
SFLA_RS24590	COG0768	penicillin binding
SFLA_RS24595	COG1414	Transcriptional regulator
SFLA_RS24630	COG1902	pentaerythritol trinitrate reductase activity
SFLA_RS24645	COG0395	ABC-type sugar transport system, permease component
SFLA_RS24650	COG1175	transmembrane transport
SFLA_RS24680	COG1917	Cupin 2, conserved barrel domain protein
SFLA_RS24695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SFLA_RS24720	COG1797	cobyrinic acid a,c-diamide synthase activity
SFLA_RS24735	COG1492	cobalamin metabolic process
SFLA_RS24740	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SFLA_RS24755	COG0235	Class ii aldolase
SFLA_RS24775	COG0488	(ABC) transporter
SFLA_RS24825	COG3387	PFAM Glycoside hydrolase 15-related
SFLA_RS24840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SFLA_RS24875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SFLA_RS24880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SFLA_RS24900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SFLA_RS24930	COG2186	Transcriptional regulator
SFLA_RS24935	COG2807	transmembrane transport
SFLA_RS24950	COG3830	Belongs to the UPF0237 family
SFLA_RS24950	COG0560	Phosphoserine phosphatase
SFLA_RS24955	COG0842	Transport permease protein
SFLA_RS24955	COG1716	ATPase activity
SFLA_RS24955	COG1131	(ABC) transporter
SFLA_RS24970	COG2197	response regulator
SFLA_RS24980	COG1119	ATPase activity
SFLA_RS25005	COG1881	PFAM PEBP family protein
SFLA_RS25015	COG2094	Belongs to the DNA glycosylase MPG family
SFLA_RS25050	COG0647	UMP catabolic process
SFLA_RS25055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS25060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS25065	COG1120	ATPase activity
SFLA_RS25085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SFLA_RS25090	COG0497	DNA recombination
SFLA_RS25095	COG0297	glycogen (starch) synthase activity
SFLA_RS25110	COG0110	maltose O-acetyltransferase activity
SFLA_RS25120	COG3387	PFAM Glycoside hydrolase 15-related
SFLA_RS25125	COG0504	CTP synthase activity
SFLA_RS25130	COG0494	nUDIX hydrolase
SFLA_RS25140	COG0686	Belongs to the AlaDH PNT family
SFLA_RS25155	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SFLA_RS25160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SFLA_RS25165	COG1187	pseudouridine synthase activity
SFLA_RS25180	COG0494	nUDIX hydrolase
SFLA_RS25190	COG3541	Predicted nucleotidyltransferase
SFLA_RS25220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SFLA_RS25230	COG1160	GTP binding
SFLA_RS25245	COG0438	transferase activity, transferring glycosyl groups
SFLA_RS25255	COG0671	phosphoesterase, PA-phosphatase related
SFLA_RS25260	COG0477	Major facilitator Superfamily
SFLA_RS25265	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS25270	COG1799	cell septum assembly
SFLA_RS25280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFLA_RS25285	COG0765	amino acid transport
SFLA_RS25300	COG1126	abc transporter atp-binding protein
SFLA_RS25305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SFLA_RS25345	COG0641	radical SAM
SFLA_RS25380	COG0587	DNA-directed DNA polymerase activity
SFLA_RS25385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SFLA_RS25400	COG3540	Alkaline phosphatase
SFLA_RS25405	COG4565	transcriptional regulatory protein
SFLA_RS25425	COG2226	methyltransferase
SFLA_RS25440	COG1725	Transcriptional regulator
SFLA_RS25455	COG2755	lipolytic protein G-D-S-L family
SFLA_RS25460	COG0515	serine threonine protein kinase
SFLA_RS25475	COG2188	Transcriptional regulator
SFLA_RS25480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SFLA_RS25485	COG1309	transcriptional regulator
SFLA_RS25495	COG2851	Citrate transporter
SFLA_RS25520	COG0640	Transcriptional regulator
SFLA_RS25530	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS25550	COG0789	Transcriptional regulator
SFLA_RS25565	COG3876	Protein conserved in bacteria
SFLA_RS25570	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS25575	COG0318	PFAM AMP-dependent synthetase and ligase
SFLA_RS25585	COG2234	aminopeptidase activity
SFLA_RS25585	COG4935	Belongs to the peptidase S8 family
SFLA_RS25590	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS25610	COG2149	membrane
SFLA_RS25615	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SFLA_RS25660	COG3265	gluconokinase activity
SFLA_RS25665	COG2186	Transcriptional regulator
SFLA_RS25680	COG0564	pseudouridine synthase activity
SFLA_RS25690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SFLA_RS25720	COG0667	Aldo Keto reductase
SFLA_RS25725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS25735	COG0598	Magnesium transport protein CorA
SFLA_RS25755	COG0215	cysteine-tRNA ligase activity
SFLA_RS25765	COG4948	Mandelate Racemase Muconate Lactonizing
SFLA_RS25770	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS25775	COG2186	Transcriptional regulator
SFLA_RS25780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SFLA_RS25785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SFLA_RS25790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SFLA_RS25795	COG1414	Transcriptional regulator
SFLA_RS25800	COG1410	methionine synthase
SFLA_RS25800	COG0646	methionine synthase
SFLA_RS25810	COG4166	transmembrane transport
SFLA_RS25815	COG2197	response regulator
SFLA_RS25825	COG0517	IMP dehydrogenase activity
SFLA_RS25825	COG1994	Peptidase M50
SFLA_RS25845	COG1222	aaa ATPase
SFLA_RS25850	COG4122	O-methyltransferase activity
SFLA_RS25860	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SFLA_RS25865	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SFLA_RS25870	COG1609	Transcriptional regulator
SFLA_RS25880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SFLA_RS25885	COG0545	Peptidyl-prolyl cis-trans isomerase
SFLA_RS25895	COG2378	regulation of single-species biofilm formation
SFLA_RS25915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SFLA_RS25920	COG0805	protein transport
SFLA_RS25960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SFLA_RS25965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SFLA_RS25990	COG1595	DNA-templated transcription, initiation
SFLA_RS26000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SFLA_RS26005	COG0517	IMP dehydrogenase activity
SFLA_RS26005	COG4175	Glycine betaine
SFLA_RS26010	COG4176	ABC-type proline glycine betaine transport system permease component
SFLA_RS26030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SFLA_RS26040	COG0174	glutamine synthetase
SFLA_RS26045	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS26085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SFLA_RS26090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SFLA_RS26095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SFLA_RS26100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SFLA_RS26105	COG5002	protein histidine kinase activity
SFLA_RS26110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SFLA_RS26115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SFLA_RS26115	COG0072	phenylalanine-tRNA ligase activity
SFLA_RS26125	COG0494	nUDIX hydrolase
SFLA_RS26130	COG1116	anion transmembrane transporter activity
SFLA_RS26140	COG1649	PFAM Uncharacterised BCR, COG1649
SFLA_RS26150	COG0697	spore germination
SFLA_RS26155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SFLA_RS26170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SFLA_RS26190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SFLA_RS26195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SFLA_RS26200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SFLA_RS26205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SFLA_RS26210	COG1438	arginine binding
SFLA_RS26220	COG0165	Argininosuccinate lyase
SFLA_RS26240	COG0477	Major facilitator Superfamily
SFLA_RS26280	COG2011	ABC-type metal ion transport system permease component
SFLA_RS26285	COG1464	Belongs to the NlpA lipoprotein family
SFLA_RS26300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SFLA_RS26305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SFLA_RS26305	COG1648	precorrin-2 dehydrogenase activity
SFLA_RS26315	COG2197	response regulator
SFLA_RS26380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SFLA_RS26390	COG0454	-acetyltransferase
SFLA_RS26390	COG0456	acetyltransferase
SFLA_RS26405	COG1609	Transcriptional regulator
SFLA_RS26435	COG1175	transmembrane transport
SFLA_RS26440	COG0395	ABC-type sugar transport system, permease component
SFLA_RS26465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SFLA_RS26480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SFLA_RS26485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SFLA_RS26500	COG3321	synthase
SFLA_RS26500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS26500	COG0604	alcohol dehydrogenase
SFLA_RS26500	COG4221	oxidoreductase activity
SFLA_RS26510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SFLA_RS26545	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS26555	COG0318	PFAM AMP-dependent synthetase and ligase
SFLA_RS26565	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS26575	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SFLA_RS26580	COG0667	Aldo Keto reductase
SFLA_RS26595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SFLA_RS26610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SFLA_RS26615	COG1560	Kdo2-lipid A biosynthetic process
SFLA_RS26620	COG0438	transferase activity, transferring glycosyl groups
SFLA_RS26630	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SFLA_RS26635	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SFLA_RS26640	COG0217	transcriptional regulatory protein
SFLA_RS26645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SFLA_RS26650	COG0632	four-way junction helicase activity
SFLA_RS26655	COG2255	four-way junction helicase activity
SFLA_RS26665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SFLA_RS26670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SFLA_RS26675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SFLA_RS26680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SFLA_RS26685	COG1196	nuclear chromosome segregation
SFLA_RS26700	COG0124	histidyl-tRNA synthetase
SFLA_RS26720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SFLA_RS26740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SFLA_RS26745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SFLA_RS26750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SFLA_RS26765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SFLA_RS26770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SFLA_RS26775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SFLA_RS26785	COG0006	proline dipeptidase activity
SFLA_RS26790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SFLA_RS26795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SFLA_RS26805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SFLA_RS26810	COG0540	Belongs to the ATCase OTCase family
SFLA_RS26815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SFLA_RS26825	COG0505	Belongs to the CarA family
SFLA_RS26830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SFLA_RS26835	COG0167	dihydroorotate dehydrogenase activity
SFLA_RS26840	COG0284	orotidine-5'-phosphate decarboxylase activity
SFLA_RS26855	COG1758	RNA polymerase activity
SFLA_RS26865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SFLA_RS26880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SFLA_RS26890	COG2175	clavaminate synthase activity
SFLA_RS26900	COG4521	taurine ABC transporter
SFLA_RS26905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SFLA_RS26915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SFLA_RS26920	COG2390	Transcriptional regulator
SFLA_RS26935	COG1012	belongs to the aldehyde dehydrogenase family
SFLA_RS26945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SFLA_RS26955	COG2233	PERMEase
SFLA_RS26960	COG0738	Major facilitator superfamily
SFLA_RS26965	COG1940	carbohydrate kinase activity
SFLA_RS26965	COG1846	Transcriptional regulator
SFLA_RS26980	COG3201	nicotinamide mononucleotide transporter
SFLA_RS26985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SFLA_RS26985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SFLA_RS26990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SFLA_RS26995	COG0140	phosphoribosyl-ATP diphosphatase activity
SFLA_RS27000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SFLA_RS27075	COG4555	ABC transporter
SFLA_RS27110	COG0783	Belongs to the Dps family
SFLA_RS27150	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS27170	COG1216	Glycosyl transferase, family 2
SFLA_RS27175	COG3030	protein affecting phage T7 exclusion by the F plasmid
SFLA_RS27185	COG2270	Major facilitator Superfamily
SFLA_RS27195	COG2364	Membrane
SFLA_RS27265	COG2018	Roadblock/LC7 domain
SFLA_RS27285	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SFLA_RS27300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SFLA_RS27310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SFLA_RS27340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SFLA_RS27360	COG1716	ATPase activity
SFLA_RS27380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SFLA_RS27390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SFLA_RS27390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SFLA_RS27420	COG1695	Transcriptional regulator
SFLA_RS27445	COG0697	spore germination
SFLA_RS27475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SFLA_RS27490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SFLA_RS27495	COG1316	TRANSCRIPTIONal
SFLA_RS27505	COG0640	Transcriptional regulator
SFLA_RS27510	COG2208	phosphoserine phosphatase activity
SFLA_RS27510	COG2770	Histidine kinase
SFLA_RS27540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SFLA_RS27550	COG2318	DinB family
SFLA_RS27560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SFLA_RS27570	COG0243	molybdopterin cofactor binding
SFLA_RS27575	COG1968	undecaprenyl-diphosphatase activity
SFLA_RS27600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SFLA_RS27660	COG1832	CoA-binding protein
SFLA_RS27665	COG1739	Uncharacterized protein family UPF0029
SFLA_RS27670	COG0420	3'-5' exonuclease activity
SFLA_RS27675	COG0419	ATPase involved in DNA repair
SFLA_RS27680	COG1522	sequence-specific DNA binding
SFLA_RS27720	COG1595	DNA-templated transcription, initiation
SFLA_RS27725	COG2188	Transcriptional regulator
SFLA_RS27730	COG1940	carbohydrate kinase activity
SFLA_RS27735	COG2197	response regulator
SFLA_RS27740	COG4585	Histidine kinase
SFLA_RS27765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SFLA_RS27785	COG0702	epimerase
SFLA_RS27795	COG2239	Acts as a magnesium transporter
SFLA_RS27815	COG0516	GMP reductase activity
SFLA_RS27815	COG0517	IMP dehydrogenase activity
SFLA_RS27820	COG0589	response to stress
SFLA_RS27845	COG0517	IMP dehydrogenase activity
SFLA_RS27845	COG0516	GMP reductase activity
SFLA_RS27865	COG1063	alcohol dehydrogenase
SFLA_RS27890	COG1595	DNA-templated transcription, initiation
SFLA_RS27940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SFLA_RS27945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SFLA_RS27950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SFLA_RS27955	COG0156	8-amino-7-oxononanoate synthase activity
SFLA_RS27975	COG0740	serine-type endopeptidase activity
SFLA_RS27990	COG1309	transcriptional regulator
SFLA_RS27995	COG0831	urea catabolic process
SFLA_RS28000	COG0832	Belongs to the urease beta subunit family
SFLA_RS28005	COG0804	urea catabolic process
SFLA_RS28015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SFLA_RS28020	COG0829	nickel cation binding
SFLA_RS28035	COG0204	Acyl-transferase
SFLA_RS28065	COG0205	6-phosphofructokinase activity
SFLA_RS28070	COG3442	glutamine amidotransferase
SFLA_RS28080	COG0242	peptide deformylase activity
SFLA_RS28090	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS28095	COG0386	Belongs to the glutathione peroxidase family
SFLA_RS28130	COG1946	Acyl-CoA thioesterase
SFLA_RS28145	COG1793	dna ligase
SFLA_RS28155	COG1132	(ABC) transporter
SFLA_RS28160	COG1132	(ABC) transporter
SFLA_RS28175	COG1132	(ABC) transporter
SFLA_RS28180	COG1408	metallophosphoesterase
SFLA_RS28215	COG0739	heme binding
SFLA_RS28250	COG1309	transcriptional regulator
SFLA_RS28275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SFLA_RS28280	COG0456	acetyltransferase
SFLA_RS28290	COG1917	Cupin 2, conserved barrel domain protein
SFLA_RS28305	COG0747	negative chemotaxis
SFLA_RS28310	COG0601	transmembrane transport
SFLA_RS28315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS28320	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS28335	COG4948	Mandelate Racemase Muconate Lactonizing
SFLA_RS28345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SFLA_RS28350	COG2186	Transcriptional regulator
SFLA_RS28365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SFLA_RS28370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SFLA_RS28370	COG1263	PTS System
SFLA_RS28380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SFLA_RS28390	COG0254	rRNA binding
SFLA_RS28400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SFLA_RS28405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SFLA_RS28420	COG1349	DNA-binding transcription factor activity
SFLA_RS28515	COG0667	Aldo Keto reductase
SFLA_RS28520	COG0515	serine threonine protein kinase
SFLA_RS28520	COG2815	serine threonine protein kinase
SFLA_RS28525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SFLA_RS28535	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS28540	COG1309	transcriptional regulator
SFLA_RS28555	COG2706	6-phosphogluconolactonase activity
SFLA_RS28570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SFLA_RS28595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SFLA_RS28600	COG1609	Transcriptional regulator
SFLA_RS28610	COG1175	transmembrane transport
SFLA_RS28620	COG1472	Belongs to the glycosyl hydrolase 3 family
SFLA_RS28630	COG1902	pentaerythritol trinitrate reductase activity
SFLA_RS28665	COG0671	phosphoesterase, PA-phosphatase related
SFLA_RS28685	COG0584	glycerophosphoryl diester phosphodiesterase
SFLA_RS28725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SFLA_RS28745	COG0494	nUDIX hydrolase
SFLA_RS28755	COG0445	tRNA wobble uridine modification
SFLA_RS28785	COG1940	carbohydrate kinase activity
SFLA_RS28825	COG1349	DNA-binding transcription factor activity
SFLA_RS28865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SFLA_RS28885	COG1366	Belongs to the anti-sigma-factor antagonist family
SFLA_RS28890	COG1366	Belongs to the anti-sigma-factor antagonist family
SFLA_RS28895	COG2172	sigma factor antagonist activity
SFLA_RS28905	COG5002	protein histidine kinase activity
SFLA_RS28905	COG2198	Histidine kinase
SFLA_RS28905	COG0784	Response regulator, receiver
SFLA_RS28930	COG0395	ABC-type sugar transport system, permease component
SFLA_RS28935	COG1175	transmembrane transport
SFLA_RS28955	COG0142	geranyltranstransferase activity
SFLA_RS28970	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS28975	COG0385	Bile acid
SFLA_RS29000	COG0494	nUDIX hydrolase
SFLA_RS29020	COG1349	DNA-binding transcription factor activity
SFLA_RS29035	COG3395	kinase activity
SFLA_RS29040	COG0235	Class ii aldolase
SFLA_RS29060	COG3548	integral membrane protein
SFLA_RS29085	COG2197	response regulator
SFLA_RS29090	COG4585	Histidine kinase
SFLA_RS29110	COG0714	Associated with various cellular activities
SFLA_RS29155	COG1132	(ABC) transporter
SFLA_RS29165	COG0024	Methionine aminopeptidase
SFLA_RS29190	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SFLA_RS29195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SFLA_RS29200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SFLA_RS29250	COG1175	transmembrane transport
SFLA_RS29255	COG0395	ABC-type sugar transport system, permease component
SFLA_RS29270	COG1755	Isoprenylcysteine carboxyl methyltransferase
SFLA_RS29285	COG2409	Drug exporters of the RND superfamily
SFLA_RS29290	COG3290	protein histidine kinase activity
SFLA_RS29295	COG2226	methyltransferase
SFLA_RS29295	COG1073	alpha beta
SFLA_RS29310	COG1349	DNA-binding transcription factor activity
SFLA_RS29330	COG1063	alcohol dehydrogenase
SFLA_RS29360	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS29365	COG0328	RNA-DNA hybrid ribonuclease activity
SFLA_RS29390	COG3401	FG-GAP repeat protein
SFLA_RS29400	COG1505	serine-type exopeptidase activity
SFLA_RS29410	COG0583	DNA-binding transcription factor activity
SFLA_RS29420	COG1609	Transcriptional regulator
SFLA_RS29440	COG1879	ABC-type sugar transport system periplasmic component
SFLA_RS29445	COG1129	ABC transporter
SFLA_RS29455	COG1172	Belongs to the binding-protein-dependent transport system permease family
SFLA_RS29460	COG1609	Transcriptional regulator
SFLA_RS29470	COG0366	Alpha amylase catalytic
SFLA_RS29470	COG1874	Beta-galactosidase
SFLA_RS29475	COG1609	Transcriptional regulator
SFLA_RS29485	COG0395	ABC-type sugar transport system, permease component
SFLA_RS29490	COG1653	transport
SFLA_RS29500	COG3250	beta-galactosidase activity
SFLA_RS29510	COG4733	cellulase activity
SFLA_RS29510	COG5297	Belongs to the glycosyl hydrolase family 6
SFLA_RS29520	COG1175	transmembrane transport
SFLA_RS29525	COG0395	ABC-type sugar transport system, permease component
SFLA_RS29530	COG0366	Alpha amylase catalytic
SFLA_RS29540	COG1295	ribonuclease BN
SFLA_RS29540	COG1959	2 iron, 2 sulfur cluster binding
SFLA_RS29555	COG0254	rRNA binding
SFLA_RS29575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SFLA_RS29580	COG1120	ATPase activity
SFLA_RS29635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SFLA_RS29645	COG1191	sigma factor activity
SFLA_RS29660	COG0488	(ABC) transporter
SFLA_RS29680	COG1461	Dihydroxyacetone kinase
SFLA_RS29685	COG2376	Dihydroxyacetone kinase
SFLA_RS29695	COG5002	protein histidine kinase activity
SFLA_RS29700	COG0745	RESPONSE REGULATOR receiver
SFLA_RS29745	COG2304	oxidoreductase activity
SFLA_RS29765	COG0438	transferase activity, transferring glycosyl groups
SFLA_RS29790	COG0297	glycogen (starch) synthase activity
SFLA_RS29790	COG0438	transferase activity, transferring glycosyl groups
SFLA_RS29800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SFLA_RS29820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SFLA_RS29830	COG2365	Tyrosine phosphatase family
SFLA_RS29875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS29885	COG2080	2 iron, 2 sulfur cluster binding
SFLA_RS29890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SFLA_RS29895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SFLA_RS29910	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SFLA_RS29925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SFLA_RS29925	COG2066	Belongs to the glutaminase family
SFLA_RS29930	COG2356	endonuclease I
SFLA_RS29940	COG2813	Specifically methylates the guanine in position
SFLA_RS29950	COG0515	serine threonine protein kinase
SFLA_RS29950	COG2815	serine threonine protein kinase
SFLA_RS29975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SFLA_RS29980	COG0318	PFAM AMP-dependent synthetase and ligase
SFLA_RS30000	COG0596	Alpha beta hydrolase
SFLA_RS30025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SFLA_RS30030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SFLA_RS30090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SFLA_RS30105	COG5297	Belongs to the glycosyl hydrolase family 6
SFLA_RS30110	COG4733	cellulase activity
SFLA_RS30110	COG5297	Belongs to the glycosyl hydrolase family 6
SFLA_RS30145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SFLA_RS30155	COG1105	Belongs to the carbohydrate kinase PfkB family
SFLA_RS30160	COG1349	DNA-binding transcription factor activity
SFLA_RS30205	COG0346	lactoylglutathione lyase activity
SFLA_RS30210	COG0789	Transcriptional regulator
SFLA_RS30275	COG0584	glycerophosphoryl diester phosphodiesterase
SFLA_RS30285	COG1278	Cold shock
SFLA_RS30295	COG2814	Major facilitator Superfamily
SFLA_RS30305	COG3795	YCII-related domain
SFLA_RS30310	COG4941	Belongs to the sigma-70 factor family
SFLA_RS30320	COG0346	lactoylglutathione lyase activity
SFLA_RS30340	COG4977	sequence-specific DNA binding
SFLA_RS30350	COG2259	Doxx family
SFLA_RS30395	COG1113	amino acid transport
SFLA_RS30400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SFLA_RS30405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SFLA_RS30425	COG4106	trans-aconitate 2-methyltransferase activity
SFLA_RS30435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SFLA_RS30440	COG0300	oxidoreductase activity
SFLA_RS30455	COG1891	lyase activity
SFLA_RS30470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SFLA_RS30500	COG3511	phospholipase C
SFLA_RS30535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SFLA_RS30555	COG2261	transglycosylase associated protein
SFLA_RS30575	COG1191	sigma factor activity
SFLA_RS30610	COG1121	(ABC) transporter
SFLA_RS30615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SFLA_RS30625	COG0803	Belongs to the bacterial solute-binding protein 9 family
SFLA_RS30640	COG2267	carboxylic ester hydrolase activity
SFLA_RS30705	COG3940	Belongs to the glycosyl hydrolase 43 family
SFLA_RS30730	COG0586	Pfam SNARE associated Golgi protein
SFLA_RS30745	COG0148	phosphopyruvate hydratase activity
SFLA_RS30755	COG2010	Cytochrome c
SFLA_RS30755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SFLA_RS30770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SFLA_RS30780	COG2226	methyltransferase
SFLA_RS30810	COG0673	inositol 2-dehydrogenase activity
SFLA_RS30835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SFLA_RS30840	COG0798	PFAM Bile acid sodium symporter
SFLA_RS30845	COG0640	Transcriptional regulator
SFLA_RS30865	COG1960	acyl-CoA dehydrogenase activity
SFLA_RS30875	COG0367	asparagine synthase
SFLA_RS30900	COG1045	serine acetyltransferase
SFLA_RS30920	COG3903	Transcriptional regulator
SFLA_RS30920	COG3629	intracellular signal transduction
SFLA_RS30940	COG1278	Cold shock
SFLA_RS30955	COG3693	PFAM glycoside hydrolase, family 10
SFLA_RS30970	COG1309	transcriptional regulator
SFLA_RS31005	COG2175	clavaminate synthase activity
SFLA_RS31010	COG1024	Enoyl-CoA hydratase
SFLA_RS31015	COG2124	cytochrome p450
SFLA_RS31045	COG5001	Diguanylate cyclase
SFLA_RS31045	COG3300	MHYT domain
SFLA_RS31105	COG1309	transcriptional regulator
SFLA_RS31120	COG2267	carboxylic ester hydrolase activity
SFLA_RS31150	COG2205	protein histidine kinase activity
SFLA_RS31155	COG0745	RESPONSE REGULATOR receiver
SFLA_RS31225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SFLA_RS31230	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SFLA_RS31235	COG2080	2 iron, 2 sulfur cluster binding
SFLA_RS31290	COG2319	Wd-40 repeat
SFLA_RS31290	COG4249	Peptidase C14 caspase catalytic subunit p20
SFLA_RS31310	COG0477	Major facilitator Superfamily
SFLA_RS31315	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS31360	COG0456	acetyltransferase
SFLA_RS31365	COG2814	Major facilitator Superfamily
SFLA_RS31370	COG0367	asparagine synthase
SFLA_RS31420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SFLA_RS31425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SFLA_RS31425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SFLA_RS31470	COG2318	DinB family
SFLA_RS31480	COG0601	transmembrane transport
SFLA_RS31485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SFLA_RS31490	COG0444	Belongs to the ABC transporter superfamily
SFLA_RS31520	COG2154	pterin-4-alpha-carbinolamine dehydratase
SFLA_RS31525	COG3293	Transposase
SFLA_RS31530	COG2319	Wd-40 repeat
SFLA_RS31530	COG4249	Peptidase C14 caspase catalytic subunit p20
SFLA_RS31600	COG2186	Transcriptional regulator
SFLA_RS31605	COG0129	dihydroxy-acid dehydratase activity
SFLA_RS31615	COG1472	Belongs to the glycosyl hydrolase 3 family
SFLA_RS31625	COG1175	transmembrane transport
SFLA_RS31640	COG0726	polysaccharide deacetylase
SFLA_RS31645	COG5002	protein histidine kinase activity
SFLA_RS31650	COG0745	RESPONSE REGULATOR receiver
SFLA_RS31660	COG1136	(ABC) transporter
SFLA_RS31665	COG0577	efflux transmembrane transporter activity
SFLA_RS31665	COG1136	(ABC) transporter
SFLA_RS31680	COG0300	oxidoreductase activity
SFLA_RS31685	COG1366	Belongs to the anti-sigma-factor antagonist family
SFLA_RS31695	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS31820	COG1028	Short-chain dehydrogenase reductase Sdr
SFLA_RS31860	COG0596	Alpha beta hydrolase
SFLA_RS31875	COG2197	response regulator
SFLA_RS31945	COG1733	regulation of RNA biosynthetic process
SFLA_RS31960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SFLA_RS31960	COG0574	Belongs to the PEP-utilizing enzyme family
SFLA_RS32100	COG2124	cytochrome p450
SFLA_RS32165	COG0028	Belongs to the TPP enzyme family
SFLA_RS32510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS32615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS32695	COG0189	ligase activity
SFLA_RS32790	COG0019	diaminopimelate decarboxylase activity
SFLA_RS33120	COG2124	cytochrome p450
SFLA_RS33235	COG1653	transport
SFLA_RS33325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SFLA_RS33490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SFLA_RS33495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases