locus-tag	class	description
HED23_RS00020	COG0604	alcohol dehydrogenase
HED23_RS00020	COG3321	synthase
HED23_RS00030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HED23_RS00035	COG0594	ribonuclease P activity
HED23_RS00040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HED23_RS00045	COG0706	membrane insertase activity
HED23_RS00055	COG0357	Ribosomal RNA small subunit methyltransferase G
HED23_RS00060	COG1192	Involved in chromosome partitioning
HED23_RS00075	COG3118	belongs to the thioredoxin family
HED23_RS00080	COG0492	ferredoxin-NADP+ reductase activity
HED23_RS00090	COG1595	DNA-templated transcription, initiation
HED23_RS00095	COG0515	serine threonine protein kinase
HED23_RS00095	COG2815	serine threonine protein kinase
HED23_RS00110	COG0617	tRNA 3'-terminal CCA addition
HED23_RS00130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HED23_RS00155	COG0360	Binds together with S18 to 16S ribosomal RNA
HED23_RS00160	COG0629	single-stranded DNA binding
HED23_RS00165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HED23_RS00170	COG0359	binds to the 23S rRNA
HED23_RS00180	COG0305	Participates in initiation and elongation during chromosome replication
HED23_RS00205	COG2814	Major facilitator Superfamily
HED23_RS00225	COG0626	cystathionine gamma-synthase activity
HED23_RS00230	COG1950	PFAM Membrane protein of
HED23_RS00235	COG0662	Cupin 2, conserved barrel domain protein
HED23_RS00260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HED23_RS00270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HED23_RS00275	COG1609	Transcriptional regulator
HED23_RS00280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HED23_RS00285	COG1271	oxidase subunit
HED23_RS00290	COG1294	oxidase, subunit
HED23_RS00295	COG4988	ABC transporter
HED23_RS00305	COG0561	phosphatase activity
HED23_RS00320	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HED23_RS00330	COG1131	(ABC) transporter
HED23_RS00340	COG1131	(ABC) transporter
HED23_RS00360	COG0561	phosphatase activity
HED23_RS00365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HED23_RS00375	COG2837	iron assimilation
HED23_RS00380	COG2372	response to copper ion
HED23_RS00390	COG1999	signal sequence binding
HED23_RS00410	COG0006	proline dipeptidase activity
HED23_RS00425	COG0653	protein targeting
HED23_RS00440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HED23_RS00465	COG1595	DNA-templated transcription, initiation
HED23_RS00470	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS00560	COG1660	Displays ATPase and GTPase activities
HED23_RS00570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HED23_RS00580	COG1595	DNA-templated transcription, initiation
HED23_RS00600	COG0745	RESPONSE REGULATOR receiver
HED23_RS00605	COG2205	protein histidine kinase activity
HED23_RS00615	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HED23_RS00620	COG0477	Major facilitator Superfamily
HED23_RS00635	COG3467	pyridoxamine 5'-phosphate
HED23_RS00645	COG0477	Major facilitator Superfamily
HED23_RS00660	COG1191	sigma factor activity
HED23_RS00665	COG1191	sigma factor activity
HED23_RS00680	COG0477	Major facilitator Superfamily
HED23_RS00710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HED23_RS00735	COG4941	Belongs to the sigma-70 factor family
HED23_RS00740	COG3795	YCII-related domain
HED23_RS00755	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HED23_RS00780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED23_RS00790	COG1414	Transcriptional regulator
HED23_RS00820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HED23_RS00845	COG0596	Alpha beta hydrolase
HED23_RS00875	COG0151	Belongs to the GarS family
HED23_RS00890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HED23_RS00900	COG2197	response regulator
HED23_RS00925	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HED23_RS00930	COG0047	phosphoribosylformylglycinamidine synthase activity
HED23_RS00935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HED23_RS00975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HED23_RS01010	COG1643	Atp-dependent helicase
HED23_RS01015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HED23_RS01015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HED23_RS01020	COG0785	Cytochrome C biogenesis protein
HED23_RS01050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HED23_RS01055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HED23_RS01065	COG0513	Belongs to the DEAD box helicase family
HED23_RS01145	COG1653	transport
HED23_RS01180	COG1196	nuclear chromosome segregation
HED23_RS01180	COG0741	lytic transglycosylase activity
HED23_RS01180	COG0739	heme binding
HED23_RS01195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HED23_RS01200	COG0579	oxidoreductase
HED23_RS01225	COG1252	NADH dehydrogenase
HED23_RS01240	COG1846	Transcriptional regulator
HED23_RS01260	COG3795	YCII-related domain
HED23_RS01265	COG4941	Belongs to the sigma-70 factor family
HED23_RS01270	COG2197	response regulator
HED23_RS01275	COG4585	Histidine kinase
HED23_RS01285	COG1131	(ABC) transporter
HED23_RS01330	COG0667	Aldo Keto reductase
HED23_RS01350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HED23_RS01415	COG0739	heme binding
HED23_RS01415	COG0741	lytic transglycosylase activity
HED23_RS01415	COG1196	nuclear chromosome segregation
HED23_RS01420	COG0671	phosphoesterase, PA-phosphatase related
HED23_RS01440	COG1937	Protein conserved in bacteria
HED23_RS01450	COG0306	phosphate transporter
HED23_RS01475	COG0406	alpha-ribazole phosphatase activity
HED23_RS01475	COG0494	nUDIX hydrolase
HED23_RS01495	COG1116	anion transmembrane transporter activity
HED23_RS01500	COG1725	Transcriptional regulator
HED23_RS01505	COG0456	acetyltransferase
HED23_RS01515	COG0737	Belongs to the 5'-nucleotidase family
HED23_RS01530	COG1131	(ABC) transporter
HED23_RS01565	COG0702	epimerase
HED23_RS01570	COG1733	regulation of RNA biosynthetic process
HED23_RS01585	COG3311	Transcriptional regulator
HED23_RS01610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HED23_RS01620	COG1609	Transcriptional regulator
HED23_RS01625	COG0745	RESPONSE REGULATOR receiver
HED23_RS01630	COG2267	carboxylic ester hydrolase activity
HED23_RS01650	COG2897	thiosulfate sulfurtransferase activity
HED23_RS01685	COG3485	protocatechuate 3,4-dioxygenase
HED23_RS01700	COG1490	D-aminoacyl-tRNA deacylase activity
HED23_RS01715	COG4552	Acetyltransferase involved in intracellular survival and related
HED23_RS01745	COG3467	pyridoxamine 5'-phosphate
HED23_RS01770	COG2318	DinB family
HED23_RS01810	COG0438	transferase activity, transferring glycosyl groups
HED23_RS01830	COG0697	spore germination
HED23_RS01840	COG1846	Transcriptional regulator
HED23_RS01855	COG1051	belongs to the nudix hydrolase family
HED23_RS01875	COG0588	phosphoglycerate mutase activity
HED23_RS01890	COG5002	protein histidine kinase activity
HED23_RS01905	COG1329	Transcriptional regulator
HED23_RS01910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HED23_RS01915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HED23_RS01930	COG0601	transmembrane transport
HED23_RS01940	COG0215	cysteine-tRNA ligase activity
HED23_RS01945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HED23_RS01965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HED23_RS01975	COG3842	ATPase activity
HED23_RS01995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HED23_RS02010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HED23_RS02025	COG2197	response regulator
HED23_RS02065	COG3300	MHYT domain
HED23_RS02065	COG5001	Diguanylate cyclase
HED23_RS02080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HED23_RS02110	COG0463	Glycosyl transferase, family 2
HED23_RS02170	COG1063	alcohol dehydrogenase
HED23_RS02175	COG2197	response regulator
HED23_RS02180	COG4585	Histidine kinase
HED23_RS02225	COG1263	PTS System
HED23_RS02225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED23_RS02230	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HED23_RS02235	COG1737	Transcriptional regulator
HED23_RS02270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HED23_RS02275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HED23_RS02280	COG1984	allophanate hydrolase subunit 2
HED23_RS02300	COG3973	AAA domain
HED23_RS02310	COG1061	Type III restriction enzyme res subunit
HED23_RS02320	COG2205	protein histidine kinase activity
HED23_RS02325	COG0745	RESPONSE REGULATOR receiver
HED23_RS02335	COG1929	Belongs to the glycerate kinase type-1 family
HED23_RS02360	COG3226	Transcriptional regulator
HED23_RS02370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HED23_RS02375	COG1120	ATPase activity
HED23_RS02380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS02385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS02400	COG1278	Cold shock
HED23_RS02405	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HED23_RS02410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HED23_RS02420	COG2814	Major facilitator Superfamily
HED23_RS02440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HED23_RS02450	COG2252	PERMEase
HED23_RS02480	COG0667	Aldo Keto reductase
HED23_RS02485	COG2267	carboxylic ester hydrolase activity
HED23_RS02495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HED23_RS02510	COG1937	Protein conserved in bacteria
HED23_RS02515	COG0577	efflux transmembrane transporter activity
HED23_RS02515	COG1136	(ABC) transporter
HED23_RS02550	COG1733	regulation of RNA biosynthetic process
HED23_RS02655	COG1674	ftsk spoiiie
HED23_RS02660	COG1404	Belongs to the peptidase S8 family
HED23_RS02690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HED23_RS02720	COG0642	Histidine kinase
HED23_RS02725	COG1316	TRANSCRIPTIONal
HED23_RS02730	COG0247	lactate metabolic process
HED23_RS02730	COG0277	FAD linked oxidase domain protein
HED23_RS02740	COG0583	DNA-binding transcription factor activity
HED23_RS02750	COG2318	DinB family
HED23_RS02770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HED23_RS02785	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS02790	COG1024	Enoyl-CoA hydratase
HED23_RS02805	COG0640	Transcriptional regulator
HED23_RS02815	COG0259	pyridoxamine-phosphate oxidase activity
HED23_RS02835	COG4821	SIS domain
HED23_RS02855	COG1131	(ABC) transporter
HED23_RS02900	COG1366	Belongs to the anti-sigma-factor antagonist family
HED23_RS02945	COG0501	Belongs to the peptidase M48B family
HED23_RS02955	COG1309	transcriptional regulator
HED23_RS02965	COG0515	serine threonine protein kinase
HED23_RS02965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HED23_RS02990	COG1278	Cold shock
HED23_RS02995	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HED23_RS03005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HED23_RS03025	COG1595	DNA-templated transcription, initiation
HED23_RS03030	COG2226	methyltransferase
HED23_RS03060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS03065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS03070	COG0649	NAD binding
HED23_RS03080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HED23_RS03085	COG1034	ATP synthesis coupled electron transport
HED23_RS03090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HED23_RS03095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS03100	COG0839	Belongs to the complex I subunit 6 family
HED23_RS03105	COG0713	ATP synthesis coupled electron transport
HED23_RS03110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HED23_RS03120	COG1007	ATP synthesis coupled electron transport
HED23_RS03125	COG0514	ATP-dependent DNA helicase (RecQ)
HED23_RS03145	COG2188	Transcriptional regulator
HED23_RS03155	COG0179	Fumarylacetoacetate (FAA) hydrolase
HED23_RS03165	COG3104	oligopeptide transport
HED23_RS03170	COG0142	geranyltranstransferase activity
HED23_RS03200	COG0561	phosphatase activity
HED23_RS03225	COG0702	epimerase
HED23_RS03230	COG1733	regulation of RNA biosynthetic process
HED23_RS03235	COG1013	pyruvate-flavodoxin oxidoreductase activity
HED23_RS03240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HED23_RS03240	COG0674	pyruvate-flavodoxin oxidoreductase activity
HED23_RS03260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS03265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS03270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS03275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HED23_RS03280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS03290	COG0713	ATP synthesis coupled electron transport
HED23_RS03305	COG1007	ATP synthesis coupled electron transport
HED23_RS03310	COG1970	mechanosensitive ion channel activity
HED23_RS03315	COG0501	Belongs to the peptidase M48B family
HED23_RS03320	COG3304	Inner membrane component domain
HED23_RS03325	COG2261	transglycosylase associated protein
HED23_RS03330	COG1666	GTP binding
HED23_RS03360	COG2197	response regulator
HED23_RS03365	COG4585	Histidine kinase
HED23_RS03370	COG0586	Pfam SNARE associated Golgi protein
HED23_RS03375	COG0702	epimerase
HED23_RS03395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HED23_RS03400	COG2030	dehydratase
HED23_RS03410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HED23_RS03425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HED23_RS03430	COG0436	Aminotransferase
HED23_RS03450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HED23_RS03455	COG0081	regulation of translation
HED23_RS03460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HED23_RS03465	COG0222	ribosome binding
HED23_RS03470	COG0085	RNA polymerase activity
HED23_RS03475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HED23_RS03480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HED23_RS03485	COG0049	tRNA binding
HED23_RS03490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HED23_RS03495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HED23_RS03510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HED23_RS03570	COG2226	methyltransferase
HED23_RS03575	COG2124	cytochrome p450
HED23_RS03630	COG0051	transcription antitermination factor activity, RNA binding
HED23_RS03635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HED23_RS03640	COG0088	Forms part of the polypeptide exit tunnel
HED23_RS03645	COG0089	rRNA binding
HED23_RS03650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HED23_RS03655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HED23_RS03660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HED23_RS03665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HED23_RS03670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HED23_RS03675	COG0255	Belongs to the universal ribosomal protein uL29 family
HED23_RS03680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HED23_RS03685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HED23_RS03690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HED23_RS03695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HED23_RS03700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HED23_RS03705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HED23_RS03710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HED23_RS03715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HED23_RS03720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HED23_RS03725	COG1841	ribosomal large subunit assembly
HED23_RS03730	COG0200	Binds to the 23S rRNA
HED23_RS03740	COG0563	adenylate kinase activity
HED23_RS03750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HED23_RS03755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HED23_RS03760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HED23_RS03765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HED23_RS03770	COG0202	RNA polymerase activity
HED23_RS03775	COG0203	ribosomal protein L17
HED23_RS03780	COG0101	tRNA pseudouridine synthase activity
HED23_RS03795	COG0488	(ABC) transporter
HED23_RS03800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HED23_RS03805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HED23_RS03810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HED23_RS03825	COG1072	(Pantothenic acid kinase))
HED23_RS03865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HED23_RS03870	COG0736	holo-[acyl-carrier-protein] synthase activity
HED23_RS03885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HED23_RS03895	COG0802	atpase or kinase
HED23_RS03920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HED23_RS03935	COG4941	Belongs to the sigma-70 factor family
HED23_RS03955	COG0726	polysaccharide deacetylase
HED23_RS03960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HED23_RS03980	COG2258	MOSC domain
HED23_RS03985	COG0583	DNA-binding transcription factor activity
HED23_RS03995	COG2197	response regulator
HED23_RS04000	COG1595	DNA-templated transcription, initiation
HED23_RS04010	COG0516	GMP reductase activity
HED23_RS04030	COG0515	serine threonine protein kinase
HED23_RS04040	COG0515	serine threonine protein kinase
HED23_RS04065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HED23_RS04065	COG0519	Catalyzes the synthesis of GMP from XMP
HED23_RS04110	COG2197	response regulator
HED23_RS04150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HED23_RS04170	COG0714	Associated with various cellular activities
HED23_RS04180	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HED23_RS04185	COG0045	succinate-CoA ligase (ADP-forming) activity
HED23_RS04215	COG0138	bifunctional purine biosynthesis protein purh
HED23_RS04230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HED23_RS04245	COG0039	L-malate dehydrogenase activity
HED23_RS04255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HED23_RS04260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HED23_RS04270	COG0754	glutathionylspermidine amidase activity
HED23_RS04275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HED23_RS04290	COG1595	DNA-templated transcription, initiation
HED23_RS04295	COG0180	Tryptophanyl-tRNA synthetase
HED23_RS04315	COG1295	ribonuclease BN
HED23_RS04320	COG1686	Belongs to the peptidase S11 family
HED23_RS04325	COG1408	metallophosphoesterase
HED23_RS04330	COG1309	transcriptional regulator
HED23_RS04340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HED23_RS04355	COG2009	succinate dehydrogenase
HED23_RS04365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HED23_RS04395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HED23_RS04395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HED23_RS04410	COG4409	exo-alpha-(2->6)-sialidase activity
HED23_RS04430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HED23_RS04440	COG1216	Glycosyl transferase, family 2
HED23_RS04450	COG1083	cytidylyl-transferase
HED23_RS04455	COG2089	acid synthase
HED23_RS04495	COG1473	amidohydrolase
HED23_RS04495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HED23_RS04500	COG1744	ABC transporter substrate-binding protein PnrA-like
HED23_RS04505	COG3845	ABC transporter
HED23_RS04510	COG4603	Belongs to the binding-protein-dependent transport system permease family
HED23_RS04515	COG1079	Belongs to the binding-protein-dependent transport system permease family
HED23_RS04555	COG2814	Major facilitator Superfamily
HED23_RS04560	COG0583	DNA-binding transcription factor activity
HED23_RS04570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HED23_RS04595	COG2205	protein histidine kinase activity
HED23_RS04600	COG0745	RESPONSE REGULATOR receiver
HED23_RS04605	COG1595	DNA-templated transcription, initiation
HED23_RS04620	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS04625	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS04630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HED23_RS04640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HED23_RS04670	COG4770	biotin carboxylase activity
HED23_RS04680	COG0424	maF-like protein
HED23_RS04690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HED23_RS04705	COG1024	Enoyl-CoA hydratase
HED23_RS04730	COG1376	ErfK ybiS ycfS ynhG family protein
HED23_RS04740	COG1136	(ABC) transporter
HED23_RS04745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HED23_RS04755	COG3420	alginic acid biosynthetic process
HED23_RS04770	COG1396	sequence-specific DNA binding
HED23_RS04780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HED23_RS04810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HED23_RS04825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HED23_RS04835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HED23_RS04855	COG1331	Highly conserved protein containing a thioredoxin domain
HED23_RS04865	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HED23_RS04900	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HED23_RS04915	COG1414	Transcriptional regulator
HED23_RS04920	COG0251	oxidation-reduction process
HED23_RS04925	COG2610	gluconate transmembrane transporter activity
HED23_RS04950	COG2894	cell division
HED23_RS04995	COG2885	chlorophyll binding
HED23_RS05035	COG2045	Belongs to the ComB family
HED23_RS05045	COG3135	benzoate transporter
HED23_RS05075	COG2226	methyltransferase
HED23_RS05090	COG0667	Aldo Keto reductase
HED23_RS05095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HED23_RS05100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HED23_RS05120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HED23_RS05125	COG0450	alkyl hydroperoxide reductase
HED23_RS05140	COG1136	(ABC) transporter
HED23_RS05160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HED23_RS05175	COG0114	fumarate hydratase activity
HED23_RS05180	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HED23_RS05180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HED23_RS05205	COG0778	Nitroreductase
HED23_RS05210	COG1722	exodeoxyribonuclease VII activity
HED23_RS05215	COG1570	exodeoxyribonuclease VII activity
HED23_RS05225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HED23_RS05240	COG0012	GTP binding
HED23_RS05270	COG2267	carboxylic ester hydrolase activity
HED23_RS05320	COG1842	Phage shock protein A
HED23_RS05340	COG0477	Major facilitator Superfamily
HED23_RS05345	COG1335	isochorismatase
HED23_RS05355	COG1217	gtp-binding protein TYPA
HED23_RS05370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS05375	COG0444	Belongs to the ABC transporter superfamily
HED23_RS05380	COG4608	Belongs to the ABC transporter superfamily
HED23_RS05385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HED23_RS05405	COG4166	transmembrane transport
HED23_RS05410	COG0601	transmembrane transport
HED23_RS05415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS05425	COG4608	Belongs to the ABC transporter superfamily
HED23_RS05445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HED23_RS05465	COG2912	Transglutaminase-like superfamily
HED23_RS05495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HED23_RS05500	COG1611	Belongs to the LOG family
HED23_RS05505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HED23_RS05515	COG0519	Catalyzes the synthesis of GMP from XMP
HED23_RS05520	COG1024	Enoyl-CoA hydratase
HED23_RS05535	COG1595	DNA-templated transcription, initiation
HED23_RS05545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HED23_RS05550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HED23_RS05585	COG0598	Magnesium transport protein CorA
HED23_RS05595	COG2814	Major facilitator Superfamily
HED23_RS05610	COG2095	MarC family integral membrane protein
HED23_RS05620	COG1432	Conserved Protein
HED23_RS05625	COG2267	carboxylic ester hydrolase activity
HED23_RS05630	COG0513	Belongs to the DEAD box helicase family
HED23_RS05670	COG0747	negative chemotaxis
HED23_RS05675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS05690	COG0438	transferase activity, transferring glycosyl groups
HED23_RS05740	COG0210	DNA helicase
HED23_RS05795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HED23_RS05850	COG3480	Lon protease (S16) C-terminal proteolytic domain
HED23_RS05860	COG1615	UPF0182 protein
HED23_RS05885	COG0753	catalase activity
HED23_RS05895	COG0483	inositol monophosphate 1-phosphatase activity
HED23_RS05905	COG2076	Multidrug Resistance protein
HED23_RS05910	COG1162	GTPase activity
HED23_RS05915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HED23_RS05925	COG2135	peptidase activity
HED23_RS05935	COG1595	DNA-templated transcription, initiation
HED23_RS05940	COG5662	AntiSigma factor
HED23_RS05960	COG0242	peptide deformylase activity
HED23_RS06005	COG2188	Transcriptional regulator
HED23_RS06010	COG2182	Extracellular solute-binding protein
HED23_RS06015	COG1175	transmembrane transport
HED23_RS06020	COG0395	ABC-type sugar transport system, permease component
HED23_RS06025	COG1472	Belongs to the glycosyl hydrolase 3 family
HED23_RS06030	COG0363	glucosamine-6-phosphate deaminase activity
HED23_RS06045	COG1597	lipid kinase activity
HED23_RS06060	COG2172	sigma factor antagonist activity
HED23_RS06085	COG1017	nitric oxide dioxygenase activity
HED23_RS06085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HED23_RS06090	COG1959	2 iron, 2 sulfur cluster binding
HED23_RS06095	COG0277	FAD linked oxidase domain protein
HED23_RS06105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HED23_RS06110	COG0142	geranyltranstransferase activity
HED23_RS06115	COG0456	acetyltransferase
HED23_RS06125	COG5640	endopeptidase activity
HED23_RS06170	COG0515	serine threonine protein kinase
HED23_RS06170	COG2815	serine threonine protein kinase
HED23_RS06255	COG4106	trans-aconitate 2-methyltransferase activity
HED23_RS06260	COG1595	DNA-templated transcription, initiation
HED23_RS06270	COG1126	abc transporter atp-binding protein
HED23_RS06275	COG0765	amino acid transport
HED23_RS06285	COG0281	malic enzyme
HED23_RS06290	COG0604	alcohol dehydrogenase
HED23_RS06330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HED23_RS06330	COG0567	Dehydrogenase, E1 component
HED23_RS06335	COG2205	protein histidine kinase activity
HED23_RS06340	COG0745	RESPONSE REGULATOR receiver
HED23_RS06355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HED23_RS06360	COG0726	polysaccharide deacetylase
HED23_RS06380	COG5002	protein histidine kinase activity
HED23_RS06455	COG0768	penicillin binding
HED23_RS06475	COG1793	dna ligase
HED23_RS06475	COG3285	dna ligase
HED23_RS06480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HED23_RS06490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HED23_RS06500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HED23_RS06545	COG0018	arginyl-trna synthetase
HED23_RS06550	COG0019	diaminopimelate decarboxylase activity
HED23_RS06555	COG0460	homoserine dehydrogenase
HED23_RS06560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HED23_RS06565	COG0083	homoserine kinase activity
HED23_RS06580	COG1316	TRANSCRIPTIONal
HED23_RS06585	COG0254	rRNA binding
HED23_RS06590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HED23_RS06595	COG2890	protein-(glutamine-N5) methyltransferase activity
HED23_RS06605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HED23_RS06610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HED23_RS06630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HED23_RS06635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HED23_RS06640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HED23_RS06645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HED23_RS06650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HED23_RS06655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HED23_RS06660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HED23_RS06680	COG2197	response regulator
HED23_RS06685	COG4585	Histidine kinase
HED23_RS06700	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED23_RS06715	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HED23_RS06770	COG0183	Belongs to the thiolase family
HED23_RS06780	COG0515	serine threonine protein kinase
HED23_RS06780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HED23_RS06795	COG0745	RESPONSE REGULATOR receiver
HED23_RS06800	COG5002	protein histidine kinase activity
HED23_RS06860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HED23_RS06860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HED23_RS06905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HED23_RS06910	COG0280	phosphate acetyltransferase
HED23_RS06910	COG0857	belongs to the CobB CobQ family
HED23_RS06915	COG0205	6-phosphofructokinase activity
HED23_RS06925	COG4565	transcriptional regulatory protein
HED23_RS06930	COG3290	protein histidine kinase activity
HED23_RS06935	COG1301	dicarboxylic acid transport
HED23_RS06960	COG3118	belongs to the thioredoxin family
HED23_RS06960	COG0492	ferredoxin-NADP+ reductase activity
HED23_RS07000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HED23_RS07010	COG0366	Alpha amylase catalytic
HED23_RS07015	COG0366	Alpha amylase catalytic
HED23_RS07020	COG0058	SHG alpha-glucan phosphorylase activity
HED23_RS07060	COG1132	(ABC) transporter
HED23_RS07065	COG1132	(ABC) transporter
HED23_RS07070	COG2197	response regulator
HED23_RS07080	COG1376	ErfK ybiS ycfS ynhG family protein
HED23_RS07120	COG1131	(ABC) transporter
HED23_RS07130	COG1760	l-serine dehydratase
HED23_RS07135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HED23_RS07140	COG0509	glycine decarboxylation via glycine cleavage system
HED23_RS07145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HED23_RS07180	COG0444	Belongs to the ABC transporter superfamily
HED23_RS07190	COG2860	membrane
HED23_RS07200	COG2378	regulation of single-species biofilm formation
HED23_RS07245	COG0482	sulfurtransferase activity
HED23_RS07265	COG4221	oxidoreductase activity
HED23_RS07280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HED23_RS07290	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HED23_RS07295	COG0154	amidase activity
HED23_RS07305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HED23_RS07315	COG2409	Drug exporters of the RND superfamily
HED23_RS07335	COG2197	response regulator
HED23_RS07345	COG2133	pyrroloquinoline quinone binding
HED23_RS07350	COG0667	Aldo Keto reductase
HED23_RS07370	COG0440	acetolactate synthase activity
HED23_RS07375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HED23_RS07380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HED23_RS07390	COG2508	Transcriptional regulator
HED23_RS07395	COG0506	proline dehydrogenase activity
HED23_RS07400	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS07410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HED23_RS07425	COG0473	3-isopropylmalate dehydrogenase activity
HED23_RS07430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HED23_RS07435	COG0831	urea catabolic process
HED23_RS07435	COG0832	Belongs to the urease beta subunit family
HED23_RS07440	COG0804	urea catabolic process
HED23_RS07445	COG2957	Belongs to the agmatine deiminase family
HED23_RS07455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HED23_RS07500	COG0601	transmembrane transport
HED23_RS07505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS07510	COG0444	Belongs to the ABC transporter superfamily
HED23_RS07520	COG1472	Belongs to the glycosyl hydrolase 3 family
HED23_RS07535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS07540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS07545	COG1120	ATPase activity
HED23_RS07550	COG4607	ABC-type enterochelin transport system periplasmic component
HED23_RS07555	COG2326	polyphosphate kinase activity
HED23_RS07650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HED23_RS07670	COG2018	Roadblock/LC7 domain
HED23_RS07690	COG2018	Roadblock/LC7 domain
HED23_RS07695	COG5002	protein histidine kinase activity
HED23_RS07705	COG0179	Fumarylacetoacetate (FAA) hydrolase
HED23_RS07710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HED23_RS07725	COG0732	type I restriction modification DNA specificity domain
HED23_RS07730	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HED23_RS07735	COG0546	phosphoglycolate phosphatase activity
HED23_RS07765	COG1414	Transcriptional regulator
HED23_RS07770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HED23_RS07775	COG0066	3-isopropylmalate dehydratase activity
HED23_RS07785	COG0776	regulation of translation
HED23_RS07795	COG1920	GTP binding
HED23_RS07805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HED23_RS07810	COG1181	Belongs to the D-alanine--D-alanine ligase family
HED23_RS07830	COG0351	phosphomethylpyrimidine kinase
HED23_RS07835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HED23_RS07840	COG1461	Dihydroxyacetone kinase
HED23_RS07845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HED23_RS07850	COG0742	ribosomal rna small subunit methyltransferase
HED23_RS07855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HED23_RS07870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HED23_RS07875	COG0571	ribonuclease III activity
HED23_RS07880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HED23_RS07885	COG1733	regulation of RNA biosynthetic process
HED23_RS07895	COG2340	Cysteine-rich secretory protein family
HED23_RS07900	COG1254	Belongs to the acylphosphatase family
HED23_RS07910	COG1196	nuclear chromosome segregation
HED23_RS07915	COG0477	Major facilitator Superfamily
HED23_RS07920	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HED23_RS07950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HED23_RS07970	COG0228	four-way junction DNA binding
HED23_RS07975	COG1837	Belongs to the UPF0109 family
HED23_RS07980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HED23_RS07985	COG0336	Belongs to the RNA methyltransferase TrmD family
HED23_RS07990	COG0335	large ribosomal subunit rRNA binding
HED23_RS07995	COG0681	Belongs to the peptidase S26 family
HED23_RS08000	COG0681	Belongs to the peptidase S26 family
HED23_RS08010	COG0681	Belongs to the peptidase S26 family
HED23_RS08015	COG1051	belongs to the nudix hydrolase family
HED23_RS08025	COG0792	nuclease activity
HED23_RS08040	COG1191	sigma factor activity
HED23_RS08055	COG0052	Belongs to the universal ribosomal protein uS2 family
HED23_RS08060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HED23_RS08065	COG0528	UMP kinase activity
HED23_RS08070	COG0233	cytoplasmic translational termination
HED23_RS08085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HED23_RS08100	COG3842	ATPase activity
HED23_RS08130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HED23_RS08140	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS08155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HED23_RS08160	COG2197	response regulator
HED23_RS08165	COG4585	Histidine kinase
HED23_RS08180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HED23_RS08200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HED23_RS08205	COG3842	ATPase activity
HED23_RS08210	COG1176	ABC-type spermidine putrescine transport system, permease component I
HED23_RS08215	COG1177	transmembrane transport
HED23_RS08220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HED23_RS08250	COG2508	Transcriptional regulator
HED23_RS08255	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS08275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HED23_RS08290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HED23_RS08295	COG0750	zinc metalloprotease
HED23_RS08300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HED23_RS08315	COG0442	prolyl-tRNA aminoacylation
HED23_RS08335	COG0779	Required for maturation of 30S ribosomal subunits
HED23_RS08350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HED23_RS08360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HED23_RS08365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HED23_RS08395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS08400	COG0601	transmembrane transport
HED23_RS08405	COG0747	negative chemotaxis
HED23_RS08410	COG0455	bacterial-type flagellum organization
HED23_RS08430	COG3266	domain, Protein
HED23_RS08435	COG1404	Belongs to the peptidase S8 family
HED23_RS08450	COG1404	Belongs to the peptidase S8 family
HED23_RS08495	COG1674	ftsk spoiiie
HED23_RS08505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HED23_RS08510	COG1185	polyribonucleotide nucleotidyltransferase activity
HED23_RS08515	COG0612	Peptidase, M16
HED23_RS08520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HED23_RS08540	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HED23_RS08545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED23_RS08550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HED23_RS08580	COG0640	Transcriptional regulator
HED23_RS08585	COG0346	lactoylglutathione lyase activity
HED23_RS08605	COG1674	ftsk spoiiie
HED23_RS08615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HED23_RS08625	COG1546	Belongs to the CinA family
HED23_RS08625	COG1058	Belongs to the CinA family
HED23_RS08630	COG1396	sequence-specific DNA binding
HED23_RS08635	COG0783	Belongs to the Dps family
HED23_RS08640	COG3237	CsbD-like
HED23_RS08650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HED23_RS08655	COG1201	RNA secondary structure unwinding
HED23_RS08660	COG2207	Transcriptional regulator
HED23_RS08660	COG1917	Cupin 2, conserved barrel domain protein
HED23_RS08690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HED23_RS08720	COG0765	amino acid transport
HED23_RS08725	COG0765	amino acid transport
HED23_RS08730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED23_RS08735	COG1126	abc transporter atp-binding protein
HED23_RS08745	COG2205	protein histidine kinase activity
HED23_RS08750	COG2358	TRAP transporter, solute receptor (TAXI family
HED23_RS08755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HED23_RS08770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HED23_RS08780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HED23_RS08785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HED23_RS08795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HED23_RS08830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HED23_RS08835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HED23_RS08840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HED23_RS08855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HED23_RS08885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HED23_RS08915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HED23_RS08920	COG2186	Transcriptional regulator
HED23_RS08925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HED23_RS08950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED23_RS08955	COG4565	transcriptional regulatory protein
HED23_RS08960	COG3290	protein histidine kinase activity
HED23_RS08975	COG0372	Belongs to the citrate synthase family
HED23_RS08980	COG0372	Belongs to the citrate synthase family
HED23_RS08990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HED23_RS08995	COG0612	Peptidase, M16
HED23_RS09010	COG1802	Transcriptional regulator
HED23_RS09015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED23_RS09020	COG1042	CoA-binding domain protein
HED23_RS09020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HED23_RS09020	COG0045	succinate-CoA ligase (ADP-forming) activity
HED23_RS09035	COG1435	thymidine kinase activity
HED23_RS09070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HED23_RS09085	COG0745	RESPONSE REGULATOR receiver
HED23_RS09090	COG2205	protein histidine kinase activity
HED23_RS09115	COG0756	dUTP diphosphatase activity
HED23_RS09125	COG1136	(ABC) transporter
HED23_RS09125	COG4591	ABC-type transport system involved in lipoprotein release permease component
HED23_RS09155	COG0569	domain protein
HED23_RS09160	COG0531	amino acid
HED23_RS09165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HED23_RS09175	COG0604	alcohol dehydrogenase
HED23_RS09175	COG3321	synthase
HED23_RS09180	COG0667	Aldo Keto reductase
HED23_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS09190	COG1309	transcriptional regulator
HED23_RS09195	COG1309	transcriptional regulator
HED23_RS09200	COG1902	pentaerythritol trinitrate reductase activity
HED23_RS09235	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS09240	COG1335	isochorismatase
HED23_RS09275	COG3629	intracellular signal transduction
HED23_RS09275	COG3903	Transcriptional regulator
HED23_RS09285	COG3693	PFAM glycoside hydrolase, family 10
HED23_RS09300	COG0475	glutathione-regulated potassium exporter activity
HED23_RS09345	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HED23_RS09370	COG3483	tryptophan 2,3-dioxygenase activity
HED23_RS09375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS09380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS09380	COG3433	isochorismatase activity
HED23_RS09380	COG2226	methyltransferase
HED23_RS09385	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HED23_RS09385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS09395	COG2375	cellular response to nickel ion
HED23_RS09395	COG1132	(ABC) transporter
HED23_RS09400	COG1132	(ABC) transporter
HED23_RS09410	COG0367	asparagine synthase
HED23_RS09415	COG2197	response regulator
HED23_RS09460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HED23_RS09460	COG2070	2-Nitropropane dioxygenase
HED23_RS09470	COG1960	acyl-CoA dehydrogenase activity
HED23_RS09480	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HED23_RS09495	COG0477	Major facilitator Superfamily
HED23_RS09500	COG4585	Histidine kinase
HED23_RS09505	COG2197	response regulator
HED23_RS09530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HED23_RS09550	COG0175	sulfate reduction
HED23_RS09555	COG0674	pyruvate-flavodoxin oxidoreductase activity
HED23_RS09555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HED23_RS09560	COG1013	pyruvate-flavodoxin oxidoreductase activity
HED23_RS09565	COG2409	Drug exporters of the RND superfamily
HED23_RS09575	COG2226	methyltransferase
HED23_RS09585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HED23_RS09605	COG3046	protein related to deoxyribodipyrimidine photolyase
HED23_RS09625	COG1953	Uracil, thiamine, allantoin
HED23_RS09635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HED23_RS09645	COG0714	Associated with various cellular activities
HED23_RS09680	COG1414	Transcriptional regulator
HED23_RS09685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED23_RS09690	COG2610	gluconate transmembrane transporter activity
HED23_RS09695	COG4948	Mandelate Racemase Muconate Lactonizing
HED23_RS09705	COG0583	DNA-binding transcription factor activity
HED23_RS09730	COG0725	ABC transporter, periplasmic molybdate-binding protein
HED23_RS09735	COG3585	molybdate ion transport
HED23_RS09745	COG5280	Phage tail tape measure protein TP901
HED23_RS09745	COG3953	SLT domain
HED23_RS09755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HED23_RS09790	COG1799	cell septum assembly
HED23_RS09815	COG2040	homocysteine
HED23_RS09825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HED23_RS09835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HED23_RS09840	COG0531	amino acid
HED23_RS09850	COG1024	Enoyl-CoA hydratase
HED23_RS09885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED23_RS09910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HED23_RS09910	COG2111	Na H antiporter
HED23_RS09915	COG1006	Multisubunit Na H antiporter MnhC subunit
HED23_RS09920	COG0651	ATP synthesis coupled electron transport
HED23_RS09935	COG1320	monovalent cation:proton antiporter activity
HED23_RS09955	COG0297	glycogen (starch) synthase activity
HED23_RS09960	COG0489	protein tyrosine kinase activity
HED23_RS10000	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HED23_RS10005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HED23_RS10015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HED23_RS10025	COG0753	catalase activity
HED23_RS10040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HED23_RS10060	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HED23_RS10065	COG0714	Associated with various cellular activities
HED23_RS10075	COG3251	PFAM MbtH domain protein
HED23_RS10105	COG1120	ATPase activity
HED23_RS10130	COG4977	sequence-specific DNA binding
HED23_RS10175	COG0596	Alpha beta hydrolase
HED23_RS10180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HED23_RS10185	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HED23_RS10200	COG0492	ferredoxin-NADP+ reductase activity
HED23_RS10210	COG3384	dioxygenase
HED23_RS10235	COG2267	carboxylic ester hydrolase activity
HED23_RS10250	COG1024	Enoyl-CoA hydratase
HED23_RS10255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HED23_RS10285	COG0604	alcohol dehydrogenase
HED23_RS10365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HED23_RS10380	COG2124	cytochrome p450
HED23_RS10655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HED23_RS10665	COG1111	helicase
HED23_RS10665	COG1205	dead DEAH box helicase
HED23_RS10720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HED23_RS10735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HED23_RS10740	COG1940	carbohydrate kinase activity
HED23_RS10745	COG2723	6-phospho-beta-galactosidase activity
HED23_RS10750	COG0395	ABC-type sugar transport system, permease component
HED23_RS10755	COG1175	transmembrane transport
HED23_RS10770	COG1501	Belongs to the glycosyl hydrolase 31 family
HED23_RS10775	COG0588	phosphoglycerate mutase activity
HED23_RS10815	COG1653	transport
HED23_RS10820	COG1175	transmembrane transport
HED23_RS10825	COG0395	ABC-type sugar transport system, permease component
HED23_RS10840	COG1940	carbohydrate kinase activity
HED23_RS10845	COG4213	ABC transporter substrate-binding protein
HED23_RS10855	COG4214	carbohydrate transport
HED23_RS10860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HED23_RS10865	COG0531	amino acid
HED23_RS10875	COG1316	TRANSCRIPTIONal
HED23_RS10885	COG0438	transferase activity, transferring glycosyl groups
HED23_RS10890	COG0438	transferase activity, transferring glycosyl groups
HED23_RS10900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HED23_RS10905	COG0438	transferase activity, transferring glycosyl groups
HED23_RS10910	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED23_RS10910	COG1024	Enoyl-CoA hydratase
HED23_RS10915	COG0183	Belongs to the thiolase family
HED23_RS10935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HED23_RS10940	COG0446	pyridine nucleotide-disulphide oxidoreductase
HED23_RS10950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HED23_RS10955	COG3253	May function as heme-dependent peroxidase
HED23_RS10970	COG3220	belongs to the UPF0276 family
HED23_RS11010	COG0726	polysaccharide deacetylase
HED23_RS11040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HED23_RS11045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HED23_RS11050	COG2409	Drug exporters of the RND superfamily
HED23_RS11055	COG1309	transcriptional regulator
HED23_RS11065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HED23_RS11070	COG1802	Transcriptional regulator
HED23_RS11105	COG1222	aaa ATPase
HED23_RS11185	COG2267	carboxylic ester hydrolase activity
HED23_RS11190	COG0477	Major facilitator Superfamily
HED23_RS11205	COG1063	alcohol dehydrogenase
HED23_RS11210	COG0156	8-amino-7-oxononanoate synthase activity
HED23_RS11215	COG0583	DNA-binding transcription factor activity
HED23_RS11220	COG0346	lactoylglutathione lyase activity
HED23_RS11225	COG1072	(Pantothenic acid kinase))
HED23_RS11235	COG0667	Aldo Keto reductase
HED23_RS11315	COG1175	transmembrane transport
HED23_RS11385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HED23_RS11395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HED23_RS11400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HED23_RS11420	COG0529	Catalyzes the synthesis of activated sulfate
HED23_RS11425	COG0175	sulfate reduction
HED23_RS11435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED23_RS11450	COG1960	acyl-CoA dehydrogenase activity
HED23_RS11470	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED23_RS11475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HED23_RS11480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HED23_RS11485	COG0583	DNA-binding transcription factor activity
HED23_RS11495	COG0477	Major facilitator Superfamily
HED23_RS11540	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HED23_RS11550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED23_RS11555	COG2186	Transcriptional regulator
HED23_RS11570	COG3458	cephalosporin-C deacetylase activity
HED23_RS11580	COG0747	negative chemotaxis
HED23_RS11590	COG0444	Belongs to the ABC transporter superfamily
HED23_RS11595	COG4608	Belongs to the ABC transporter superfamily
HED23_RS11600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED23_RS11640	COG1162	GTPase activity
HED23_RS11660	COG0028	Belongs to the TPP enzyme family
HED23_RS11675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS11680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS11685	COG1120	ATPase activity
HED23_RS11715	COG1802	Transcriptional regulator
HED23_RS11740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HED23_RS11745	COG2252	PERMEase
HED23_RS11790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED23_RS11815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HED23_RS11825	COG1116	anion transmembrane transporter activity
HED23_RS11830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS11845	COG0477	Major facilitator Superfamily
HED23_RS11850	COG0435	Glutathione S-transferase
HED23_RS11865	COG2197	response regulator
HED23_RS11870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HED23_RS11875	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS11890	COG3960	tartronate-semialdehyde synthase activity
HED23_RS11905	COG0753	catalase activity
HED23_RS11910	COG2084	Dehydrogenase
HED23_RS11915	COG3622	Belongs to the hyi family
HED23_RS11920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HED23_RS11930	COG0395	ABC-type sugar transport system, permease component
HED23_RS11935	COG1175	transmembrane transport
HED23_RS11945	COG2188	Transcriptional regulator
HED23_RS11965	COG2351	hydroxyisourate hydrolase activity
HED23_RS11985	COG2233	PERMEase
HED23_RS12040	COG3864	Putative metallopeptidase domain
HED23_RS12080	COG1349	DNA-binding transcription factor activity
HED23_RS12090	COG0494	nUDIX hydrolase
HED23_RS12105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HED23_RS12120	COG1414	Transcriptional regulator
HED23_RS12125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HED23_RS12130	COG4266	Belongs to the allantoicase family
HED23_RS12135	COG2318	DinB family
HED23_RS12145	COG0656	L-ascorbic acid biosynthetic process
HED23_RS12185	COG2197	response regulator
HED23_RS12205	COG0673	inositol 2-dehydrogenase activity
HED23_RS12210	COG2188	Transcriptional regulator
HED23_RS12225	COG1129	ABC transporter
HED23_RS12230	COG1940	carbohydrate kinase activity
HED23_RS12250	COG1115	amino acid carrier protein
HED23_RS12265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HED23_RS12300	COG1126	abc transporter atp-binding protein
HED23_RS12305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED23_RS12310	COG0765	amino acid transport
HED23_RS12315	COG0765	amino acid transport
HED23_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS12340	COG2124	cytochrome p450
HED23_RS12345	COG2124	cytochrome p450
HED23_RS12350	COG2267	carboxylic ester hydrolase activity
HED23_RS12365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS12370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS12375	COG0019	diaminopimelate decarboxylase activity
HED23_RS12390	COG3321	synthase
HED23_RS12390	COG0604	alcohol dehydrogenase
HED23_RS12395	COG3321	synthase
HED23_RS12395	COG0604	alcohol dehydrogenase
HED23_RS12415	COG0604	alcohol dehydrogenase
HED23_RS12415	COG3321	synthase
HED23_RS12420	COG0604	alcohol dehydrogenase
HED23_RS12420	COG3321	synthase
HED23_RS12430	COG1136	(ABC) transporter
HED23_RS12430	COG0577	efflux transmembrane transporter activity
HED23_RS12445	COG2197	response regulator
HED23_RS12455	COG0405	Gamma-glutamyltransferase
HED23_RS12510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HED23_RS12530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS12535	COG1953	Uracil, thiamine, allantoin
HED23_RS12555	COG4106	trans-aconitate 2-methyltransferase activity
HED23_RS12565	COG3851	Histidine kinase
HED23_RS12570	COG2197	response regulator
HED23_RS12575	COG2838	Isocitrate dehydrogenase
HED23_RS12585	COG0019	diaminopimelate decarboxylase activity
HED23_RS12590	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HED23_RS12595	COG0095	Lipoate-protein ligase
HED23_RS12615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS12620	COG0444	Belongs to the ABC transporter superfamily
HED23_RS12625	COG4608	Belongs to the ABC transporter superfamily
HED23_RS12650	COG0561	phosphatase activity
HED23_RS12680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HED23_RS12700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HED23_RS12715	COG1929	Belongs to the glycerate kinase type-1 family
HED23_RS12735	COG0559	Belongs to the binding-protein-dependent transport system permease family
HED23_RS12740	COG0559	Belongs to the binding-protein-dependent transport system permease family
HED23_RS12770	COG0688	phosphatidylethanolamine metabolic process
HED23_RS12775	COG1960	acyl-CoA dehydrogenase activity
HED23_RS12785	COG2301	Belongs to the HpcH HpaI aldolase family
HED23_RS12790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HED23_RS12790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HED23_RS12795	COG0604	alcohol dehydrogenase
HED23_RS12815	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED23_RS12825	COG0596	Alpha beta hydrolase
HED23_RS12865	COG0583	DNA-binding transcription factor activity
HED23_RS12870	COG0667	Aldo Keto reductase
HED23_RS12875	COG2362	D-Aminopeptidase
HED23_RS12880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HED23_RS12890	COG1619	proteins homologs of microcin C7 resistance protein MccF
HED23_RS12905	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HED23_RS12940	COG1414	Transcriptional regulator
HED23_RS12945	COG3386	PFAM SMP-30 Gluconolaconase
HED23_RS12995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HED23_RS13005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED23_RS13005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED23_RS13010	COG3619	membrane
HED23_RS13015	COG2154	pterin-4-alpha-carbinolamine dehydratase
HED23_RS13025	COG2226	methyltransferase
HED23_RS13040	COG0656	L-ascorbic acid biosynthetic process
HED23_RS13065	COG0024	Methionine aminopeptidase
HED23_RS13125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HED23_RS13140	COG3383	formate dehydrogenase (NAD+) activity
HED23_RS13145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HED23_RS13150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HED23_RS13165	COG1129	ABC transporter
HED23_RS13170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HED23_RS13175	COG1879	ABC-type sugar transport system periplasmic component
HED23_RS13180	COG0673	inositol 2-dehydrogenase activity
HED23_RS13200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HED23_RS13250	COG0659	secondary active sulfate transmembrane transporter activity
HED23_RS13265	COG1609	Transcriptional regulator
HED23_RS13270	COG1129	ABC transporter
HED23_RS13275	COG1879	ABC-type sugar transport system periplasmic component
HED23_RS13280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HED23_RS13285	COG1869	D-ribose catabolic process
HED23_RS13290	COG0667	Aldo Keto reductase
HED23_RS13295	COG0148	phosphopyruvate hydratase activity
HED23_RS13315	COG1309	transcriptional regulator
HED23_RS13350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HED23_RS13375	COG2353	YceI-like domain
HED23_RS13395	COG0210	DNA helicase
HED23_RS13400	COG0515	serine threonine protein kinase
HED23_RS13400	COG2815	serine threonine protein kinase
HED23_RS13410	COG3209	COG3209 Rhs family protein
HED23_RS13535	COG3507	Belongs to the glycosyl hydrolase 43 family
HED23_RS13540	COG3940	Belongs to the glycosyl hydrolase 43 family
HED23_RS13565	COG2255	four-way junction helicase activity
HED23_RS13615	COG0395	ABC-type sugar transport system, permease component
HED23_RS13620	COG4209	transmembrane transport
HED23_RS13630	COG1472	Belongs to the glycosyl hydrolase 3 family
HED23_RS13635	COG1501	Belongs to the glycosyl hydrolase 31 family
HED23_RS13645	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS13655	COG0517	IMP dehydrogenase activity
HED23_RS13655	COG4175	Glycine betaine
HED23_RS13660	COG4176	ABC-type proline glycine betaine transport system permease component
HED23_RS13705	COG1132	(ABC) transporter
HED23_RS13710	COG2124	cytochrome p450
HED23_RS13735	COG1940	carbohydrate kinase activity
HED23_RS13765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HED23_RS13770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HED23_RS13775	COG3485	protocatechuate 3,4-dioxygenase
HED23_RS13780	COG3485	protocatechuate 3,4-dioxygenase
HED23_RS13785	COG1846	Transcriptional regulator
HED23_RS13830	COG1486	melibiose metabolic process
HED23_RS13835	COG3831	ATPase activity
HED23_RS13835	COG4884	unkown
HED23_RS13865	COG3012	SEC-C Motif Domain Protein
HED23_RS13925	COG1960	acyl-CoA dehydrogenase activity
HED23_RS13970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HED23_RS14030	COG1793	dna ligase
HED23_RS14085	COG0488	(ABC) transporter
HED23_RS14100	COG0110	maltose O-acetyltransferase activity
HED23_RS14110	COG1515	deoxyribonuclease V activity
HED23_RS14120	COG3268	Saccharopine dehydrogenase
HED23_RS14125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HED23_RS14130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS14135	COG1960	acyl-CoA dehydrogenase activity
HED23_RS14140	COG0183	Belongs to the thiolase family
HED23_RS14145	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED23_RS14145	COG1024	Enoyl-CoA hydratase
HED23_RS14150	COG0789	Transcriptional regulator
HED23_RS14175	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS14195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HED23_RS14205	COG0488	(ABC) transporter
HED23_RS14215	COG1609	Transcriptional regulator
HED23_RS14230	COG4977	sequence-specific DNA binding
HED23_RS14240	COG1024	Enoyl-CoA hydratase
HED23_RS14255	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HED23_RS14285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HED23_RS14305	COG1388	LysM domain
HED23_RS14305	COG1134	teichoic acid transport
HED23_RS14310	COG1562	ergosterol biosynthetic process
HED23_RS14320	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HED23_RS14330	COG1657	PFAM Prenyltransferase squalene oxidase
HED23_RS14360	COG2365	Tyrosine phosphatase family
HED23_RS14370	COG2755	lipolytic protein G-D-S-L family
HED23_RS14380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HED23_RS14425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HED23_RS14430	COG3467	pyridoxamine 5'-phosphate
HED23_RS14440	COG1408	metallophosphoesterase
HED23_RS14475	COG1175	transmembrane transport
HED23_RS14480	COG0395	ABC-type sugar transport system, permease component
HED23_RS14485	COG3250	beta-galactosidase activity
HED23_RS14505	COG0546	phosphoglycolate phosphatase activity
HED23_RS14515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED23_RS14520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HED23_RS14540	COG0604	alcohol dehydrogenase
HED23_RS14540	COG3321	synthase
HED23_RS14600	COG0604	alcohol dehydrogenase
HED23_RS14600	COG3321	synthase
HED23_RS14605	COG0604	alcohol dehydrogenase
HED23_RS14605	COG3321	synthase
HED23_RS14625	COG2175	clavaminate synthase activity
HED23_RS14635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HED23_RS14640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HED23_RS14645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HED23_RS14655	COG2197	response regulator
HED23_RS14670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HED23_RS14695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HED23_RS14745	COG1132	(ABC) transporter
HED23_RS14755	COG1609	Transcriptional regulator
HED23_RS14760	COG0673	inositol 2-dehydrogenase activity
HED23_RS14780	COG1609	Transcriptional regulator
HED23_RS14900	COG0601	transmembrane transport
HED23_RS14910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HED23_RS14915	COG1021	2,3-dihydroxybenzoate-AMP ligase
HED23_RS14920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS14925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS14925	COG3433	isochorismatase activity
HED23_RS14925	COG2226	methyltransferase
HED23_RS14940	COG2124	cytochrome p450
HED23_RS14955	COG1132	(ABC) transporter
HED23_RS14955	COG2375	cellular response to nickel ion
HED23_RS14960	COG1132	(ABC) transporter
HED23_RS14975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HED23_RS14980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HED23_RS14985	COG0019	diaminopimelate decarboxylase activity
HED23_RS14995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HED23_RS15005	COG0254	rRNA binding
HED23_RS15015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HED23_RS15020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HED23_RS15040	COG0523	cobalamin synthesis protein
HED23_RS15065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS15070	COG1120	ATPase activity
HED23_RS15095	COG1132	(ABC) transporter
HED23_RS15100	COG1132	(ABC) transporter
HED23_RS15105	COG4608	Belongs to the ABC transporter superfamily
HED23_RS15115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS15130	COG2130	NADP-dependent
HED23_RS15135	COG1233	COG1233 Phytoene dehydrogenase and related
HED23_RS15175	COG0488	(ABC) transporter
HED23_RS15185	COG1404	Belongs to the peptidase S8 family
HED23_RS15200	COG1404	Belongs to the peptidase S8 family
HED23_RS15210	COG1404	Belongs to the peptidase S8 family
HED23_RS15210	COG4412	M6 family metalloprotease domain protein
HED23_RS15215	COG1404	Belongs to the peptidase S8 family
HED23_RS15215	COG4412	M6 family metalloprotease domain protein
HED23_RS15235	COG1414	Transcriptional regulator
HED23_RS15250	COG1404	Belongs to the peptidase S8 family
HED23_RS15250	COG4412	M6 family metalloprotease domain protein
HED23_RS15265	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HED23_RS15270	COG3227	Zinc metalloprotease (Elastase)
HED23_RS15275	COG2197	response regulator
HED23_RS15320	COG2197	response regulator
HED23_RS15340	COG0247	lactate metabolic process
HED23_RS15345	COG1139	Iron-sulfur cluster binding protein
HED23_RS15350	COG1556	Lactate utilization protein
HED23_RS15355	COG1846	Transcriptional regulator
HED23_RS15370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED23_RS15375	COG0395	ABC-type sugar transport system, permease component
HED23_RS15380	COG1175	transmembrane transport
HED23_RS15390	COG1609	Transcriptional regulator
HED23_RS15410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HED23_RS15465	COG2319	Wd-40 repeat
HED23_RS15480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HED23_RS15490	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS15500	COG2318	DinB family
HED23_RS15505	COG4581	dead DEAH box helicase
HED23_RS15510	COG1278	Cold shock
HED23_RS15525	COG1819	glycosyl
HED23_RS15575	COG1132	(ABC) transporter
HED23_RS15620	COG0419	ATPase involved in DNA repair
HED23_RS15625	COG0420	3'-5' exonuclease activity
HED23_RS15665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HED23_RS15705	COG2362	D-Aminopeptidase
HED23_RS15770	COG2208	phosphoserine phosphatase activity
HED23_RS15770	COG2770	Histidine kinase
HED23_RS15800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HED23_RS15815	COG0191	fructose-bisphosphate aldolase activity
HED23_RS15825	COG1175	transmembrane transport
HED23_RS15830	COG0395	ABC-type sugar transport system, permease component
HED23_RS15840	COG1609	Transcriptional regulator
HED23_RS15875	COG1802	Transcriptional regulator
HED23_RS15885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS15895	COG0601	transmembrane transport
HED23_RS15900	COG0444	Belongs to the ABC transporter superfamily
HED23_RS15905	COG4608	Belongs to the ABC transporter superfamily
HED23_RS15910	COG0402	S-adenosylhomocysteine deaminase activity
HED23_RS15945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HED23_RS15955	COG0798	PFAM Bile acid sodium symporter
HED23_RS15965	COG0640	Transcriptional regulator
HED23_RS16025	COG3209	COG3209 Rhs family protein
HED23_RS16075	COG4249	Peptidase C14 caspase catalytic subunit p20
HED23_RS16075	COG2319	Wd-40 repeat
HED23_RS16105	COG1280	lysine exporter protein (LysE YggA)
HED23_RS16120	COG1733	regulation of RNA biosynthetic process
HED23_RS16130	COG0747	negative chemotaxis
HED23_RS16140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS16170	COG1595	DNA-templated transcription, initiation
HED23_RS16190	COG0300	oxidoreductase activity
HED23_RS16195	COG3321	synthase
HED23_RS16200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED23_RS16205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS16210	COG1024	Enoyl-CoA hydratase
HED23_RS16215	COG1024	Enoyl-CoA hydratase
HED23_RS16220	COG3425	synthase
HED23_RS16225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HED23_RS16230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HED23_RS16230	COG2070	2-Nitropropane dioxygenase
HED23_RS16235	COG4221	oxidoreductase activity
HED23_RS16235	COG3321	synthase
HED23_RS16235	COG0300	oxidoreductase activity
HED23_RS16235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS16240	COG4221	oxidoreductase activity
HED23_RS16240	COG3321	synthase
HED23_RS16240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS16240	COG0300	oxidoreductase activity
HED23_RS16245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS16245	COG3321	synthase
HED23_RS16245	COG0300	oxidoreductase activity
HED23_RS16245	COG4221	oxidoreductase activity
HED23_RS16250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS16250	COG0300	oxidoreductase activity
HED23_RS16250	COG3321	synthase
HED23_RS16250	COG4221	oxidoreductase activity
HED23_RS16255	COG3321	synthase
HED23_RS16255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS16255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HED23_RS16255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS16265	COG2124	cytochrome p450
HED23_RS16270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HED23_RS16320	COG1196	nuclear chromosome segregation
HED23_RS16320	COG0741	lytic transglycosylase activity
HED23_RS16320	COG0739	heme binding
HED23_RS16350	COG0714	Associated with various cellular activities
HED23_RS16365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HED23_RS16395	COG2364	Membrane
HED23_RS16400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HED23_RS16405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HED23_RS16430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HED23_RS16440	COG0596	Alpha beta hydrolase
HED23_RS16490	COG0395	ABC-type sugar transport system, permease component
HED23_RS16495	COG1175	transmembrane transport
HED23_RS16580	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HED23_RS16610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED23_RS16620	COG0456	acetyltransferase
HED23_RS16630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HED23_RS16640	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS16655	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS16660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HED23_RS16685	COG2272	Belongs to the type-B carboxylesterase lipase family
HED23_RS16750	COG1162	GTPase activity
HED23_RS16755	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HED23_RS16835	COG2318	DinB family
HED23_RS16840	COG0789	Transcriptional regulator
HED23_RS16900	COG1278	Cold shock
HED23_RS16925	COG0475	glutathione-regulated potassium exporter activity
HED23_RS16925	COG0569	domain protein
HED23_RS16945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HED23_RS16960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HED23_RS17035	COG0659	secondary active sulfate transmembrane transporter activity
HED23_RS17080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HED23_RS17090	COG1113	amino acid transport
HED23_RS17095	COG2267	carboxylic ester hydrolase activity
HED23_RS17140	COG0789	Transcriptional regulator
HED23_RS17150	COG1120	ATPase activity
HED23_RS17160	COG1278	Cold shock
HED23_RS17175	COG0584	glycerophosphoryl diester phosphodiesterase
HED23_RS17255	COG0346	lactoylglutathione lyase activity
HED23_RS17295	COG1349	DNA-binding transcription factor activity
HED23_RS17300	COG1105	Belongs to the carbohydrate kinase PfkB family
HED23_RS17310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED23_RS17360	COG2318	DinB family
HED23_RS17365	COG4733	cellulase activity
HED23_RS17365	COG5297	Belongs to the glycosyl hydrolase family 6
HED23_RS17375	COG5297	Belongs to the glycosyl hydrolase family 6
HED23_RS17390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HED23_RS17395	COG4191	Histidine kinase
HED23_RS17450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS17455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED23_RS17480	COG0596	Alpha beta hydrolase
HED23_RS17505	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS17510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HED23_RS17525	COG0662	Cupin 2, conserved barrel domain protein
HED23_RS17540	COG1175	transmembrane transport
HED23_RS17545	COG0395	ABC-type sugar transport system, permease component
HED23_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS17585	COG3458	cephalosporin-C deacetylase activity
HED23_RS17600	COG0515	serine threonine protein kinase
HED23_RS17600	COG2815	serine threonine protein kinase
HED23_RS17615	COG2813	Specifically methylates the guanine in position
HED23_RS17625	COG2356	endonuclease I
HED23_RS17630	COG2066	Belongs to the glutaminase family
HED23_RS17630	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HED23_RS17650	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HED23_RS17665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HED23_RS17670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HED23_RS17675	COG2080	2 iron, 2 sulfur cluster binding
HED23_RS17690	COG0437	4 iron, 4 sulfur cluster binding
HED23_RS17695	COG0243	molybdopterin cofactor binding
HED23_RS17695	COG3383	formate dehydrogenase (NAD+) activity
HED23_RS17700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS17710	COG1230	cation diffusion facilitator family transporter
HED23_RS17770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HED23_RS17790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HED23_RS17800	COG0297	glycogen (starch) synthase activity
HED23_RS17800	COG0438	transferase activity, transferring glycosyl groups
HED23_RS17845	COG2304	oxidoreductase activity
HED23_RS17900	COG0745	RESPONSE REGULATOR receiver
HED23_RS17905	COG5002	protein histidine kinase activity
HED23_RS17915	COG2376	Dihydroxyacetone kinase
HED23_RS17920	COG1461	Dihydroxyacetone kinase
HED23_RS17940	COG0488	(ABC) transporter
HED23_RS17950	COG0454	-acetyltransferase
HED23_RS17950	COG0456	acetyltransferase
HED23_RS17955	COG1191	sigma factor activity
HED23_RS17965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HED23_RS17975	COG2084	Dehydrogenase
HED23_RS17995	COG1120	ATPase activity
HED23_RS18000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS18020	COG0254	rRNA binding
HED23_RS18045	COG1295	ribonuclease BN
HED23_RS18045	COG1959	2 iron, 2 sulfur cluster binding
HED23_RS18055	COG0366	Alpha amylase catalytic
HED23_RS18060	COG0395	ABC-type sugar transport system, permease component
HED23_RS18065	COG1175	transmembrane transport
HED23_RS18070	COG1653	transport
HED23_RS18090	COG1653	transport
HED23_RS18095	COG0395	ABC-type sugar transport system, permease component
HED23_RS18100	COG1175	transmembrane transport
HED23_RS18105	COG1609	Transcriptional regulator
HED23_RS18110	COG0366	Alpha amylase catalytic
HED23_RS18110	COG1874	Beta-galactosidase
HED23_RS18125	COG1609	Transcriptional regulator
HED23_RS18130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HED23_RS18140	COG1129	ABC transporter
HED23_RS18145	COG1879	ABC-type sugar transport system periplasmic component
HED23_RS18165	COG1609	Transcriptional regulator
HED23_RS18180	COG3537	Alpha-1,2-mannosidase
HED23_RS18190	COG3401	FG-GAP repeat protein
HED23_RS18215	COG0328	RNA-DNA hybrid ribonuclease activity
HED23_RS18220	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS18255	COG1063	alcohol dehydrogenase
HED23_RS18290	COG2226	methyltransferase
HED23_RS18295	COG3290	protein histidine kinase activity
HED23_RS18300	COG2409	Drug exporters of the RND superfamily
HED23_RS18330	COG0395	ABC-type sugar transport system, permease component
HED23_RS18335	COG1175	transmembrane transport
HED23_RS18355	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HED23_RS18365	COG1846	Transcriptional regulator
HED23_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS18405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HED23_RS18405	COG0596	Alpha beta hydrolase
HED23_RS18410	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HED23_RS18420	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS18425	COG2271	Major facilitator Superfamily
HED23_RS18435	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HED23_RS18460	COG1846	Transcriptional regulator
HED23_RS18470	COG2814	Major facilitator Superfamily
HED23_RS18495	COG2814	Major facilitator Superfamily
HED23_RS18555	COG4608	Belongs to the ABC transporter superfamily
HED23_RS18560	COG0444	Belongs to the ABC transporter superfamily
HED23_RS18565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED23_RS18570	COG0601	transmembrane transport
HED23_RS18575	COG0747	negative chemotaxis
HED23_RS18580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED23_RS18585	COG4948	Mandelate Racemase Muconate Lactonizing
HED23_RS18590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED23_RS18630	COG0385	Bile acid
HED23_RS18660	COG0697	spore germination
HED23_RS18710	COG2010	Cytochrome c
HED23_RS18710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HED23_RS18785	COG1215	transferase activity, transferring glycosyl groups
HED23_RS18805	COG1335	isochorismatase
HED23_RS18825	COG0464	growth
HED23_RS18835	COG1349	DNA-binding transcription factor activity
HED23_RS18875	COG1940	carbohydrate kinase activity
HED23_RS18880	COG2223	nitrite transmembrane transporter activity
HED23_RS18910	COG0445	tRNA wobble uridine modification
HED23_RS18930	COG0494	nUDIX hydrolase
HED23_RS18945	COG1609	Transcriptional regulator
HED23_RS18955	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HED23_RS19000	COG0584	glycerophosphoryl diester phosphodiesterase
HED23_RS19020	COG0671	phosphoesterase, PA-phosphatase related
HED23_RS19050	COG0640	Transcriptional regulator
HED23_RS19055	COG2226	methyltransferase
HED23_RS19060	COG1902	pentaerythritol trinitrate reductase activity
HED23_RS19085	COG1472	Belongs to the glycosyl hydrolase 3 family
HED23_RS19095	COG1175	transmembrane transport
HED23_RS19100	COG1653	transport
HED23_RS19105	COG1609	Transcriptional regulator
HED23_RS19140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HED23_RS19155	COG2706	6-phosphogluconolactonase activity
HED23_RS19185	COG0673	inositol 2-dehydrogenase activity
HED23_RS19200	COG0789	Transcriptional regulator
HED23_RS19215	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS19220	COG0456	acetyltransferase
HED23_RS19220	COG0454	-acetyltransferase
HED23_RS19225	COG0673	inositol 2-dehydrogenase activity
HED23_RS19230	COG1609	Transcriptional regulator
HED23_RS19240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED23_RS19245	COG0515	serine threonine protein kinase
HED23_RS19245	COG2815	serine threonine protein kinase
HED23_RS19250	COG0667	Aldo Keto reductase
HED23_RS19285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HED23_RS19290	COG1940	carbohydrate kinase activity
HED23_RS19310	COG3119	arylsulfatase activity
HED23_RS19355	COG4977	sequence-specific DNA binding
HED23_RS19370	COG1414	Transcriptional regulator
HED23_RS19410	COG0395	ABC-type sugar transport system, permease component
HED23_RS19415	COG1175	transmembrane transport
HED23_RS19425	COG1063	alcohol dehydrogenase
HED23_RS19430	COG1082	Xylose isomerase domain protein TIM barrel
HED23_RS19435	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HED23_RS19465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HED23_RS19470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HED23_RS19480	COG0254	rRNA binding
HED23_RS19490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HED23_RS19510	COG1263	PTS System
HED23_RS19510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED23_RS19515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HED23_RS19525	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS19565	COG2409	Drug exporters of the RND superfamily
HED23_RS19580	COG2070	2-Nitropropane dioxygenase
HED23_RS19580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HED23_RS19590	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS19595	COG1609	Transcriptional regulator
HED23_RS19615	COG0395	ABC-type sugar transport system, permease component
HED23_RS19620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED23_RS19635	COG3903	Transcriptional regulator
HED23_RS19635	COG3629	intracellular signal transduction
HED23_RS19650	COG1045	serine acetyltransferase
HED23_RS19675	COG0367	asparagine synthase
HED23_RS19685	COG1960	acyl-CoA dehydrogenase activity
HED23_RS19715	COG1191	sigma factor activity
HED23_RS19725	COG0477	Major facilitator Superfamily
HED23_RS19730	COG2508	Transcriptional regulator
HED23_RS19730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HED23_RS19740	COG1917	Cupin 2, conserved barrel domain protein
HED23_RS19765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HED23_RS19785	COG4249	Peptidase C14 caspase catalytic subunit p20
HED23_RS19785	COG2319	Wd-40 repeat
HED23_RS19835	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS19840	COG2072	flavoprotein involved in K transport
HED23_RS19865	COG2357	RelA SpoT domain protein
HED23_RS19870	COG1335	isochorismatase
HED23_RS19895	COG2755	lipolytic protein G-D-S-L family
HED23_RS19900	COG0789	Transcriptional regulator
HED23_RS19925	COG1132	(ABC) transporter
HED23_RS19930	COG2264	protein methyltransferase activity
HED23_RS20145	COG0432	Pfam Uncharacterised protein family UPF0047
HED23_RS20160	COG1132	(ABC) transporter
HED23_RS20170	COG0277	FAD linked oxidase domain protein
HED23_RS20175	COG1132	(ABC) transporter
HED23_RS20180	COG1132	(ABC) transporter
HED23_RS20185	COG1252	NADH dehydrogenase
HED23_RS20190	COG1793	dna ligase
HED23_RS20205	COG1946	Acyl-CoA thioesterase
HED23_RS20255	COG0386	Belongs to the glutathione peroxidase family
HED23_RS20260	COG1960	acyl-CoA dehydrogenase activity
HED23_RS20270	COG0242	peptide deformylase activity
HED23_RS20280	COG3442	glutamine amidotransferase
HED23_RS20285	COG0205	6-phosphofructokinase activity
HED23_RS20335	COG0829	nickel cation binding
HED23_RS20340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HED23_RS20350	COG0804	urea catabolic process
HED23_RS20355	COG0832	Belongs to the urease beta subunit family
HED23_RS20360	COG0831	urea catabolic process
HED23_RS20365	COG1309	transcriptional regulator
HED23_RS20385	COG0740	serine-type endopeptidase activity
HED23_RS20400	COG1280	lysine exporter protein (LysE YggA)
HED23_RS20405	COG0583	DNA-binding transcription factor activity
HED23_RS20425	COG0156	8-amino-7-oxononanoate synthase activity
HED23_RS20430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HED23_RS20435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HED23_RS20440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HED23_RS20445	COG2226	methyltransferase
HED23_RS20485	COG2239	Acts as a magnesium transporter
HED23_RS20495	COG0702	epimerase
HED23_RS20515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HED23_RS20540	COG4585	Histidine kinase
HED23_RS20545	COG2197	response regulator
HED23_RS20550	COG1940	carbohydrate kinase activity
HED23_RS20555	COG2188	Transcriptional regulator
HED23_RS20560	COG1595	DNA-templated transcription, initiation
HED23_RS20575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HED23_RS20590	COG0626	cystathionine gamma-synthase activity
HED23_RS20615	COG1522	sequence-specific DNA binding
HED23_RS20620	COG0419	ATPase involved in DNA repair
HED23_RS20625	COG0420	3'-5' exonuclease activity
HED23_RS20630	COG1739	Uncharacterized protein family UPF0029
HED23_RS20635	COG1832	CoA-binding protein
HED23_RS20655	COG0110	maltose O-acetyltransferase activity
HED23_RS20695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HED23_RS20705	COG1968	undecaprenyl-diphosphatase activity
HED23_RS20710	COG2755	lipolytic protein G-D-S-L family
HED23_RS20715	COG0243	molybdopterin cofactor binding
HED23_RS20730	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HED23_RS20755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HED23_RS20840	COG0402	S-adenosylhomocysteine deaminase activity
HED23_RS20845	COG2233	PERMEase
HED23_RS20875	COG2124	cytochrome p450
HED23_RS20880	COG2318	DinB family
HED23_RS20910	COG0697	spore germination
HED23_RS20940	COG1819	glycosyl
HED23_RS20950	COG2197	response regulator
HED23_RS20955	COG4585	Histidine kinase
HED23_RS20970	COG4585	Histidine kinase
HED23_RS20975	COG2197	response regulator
HED23_RS21015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HED23_RS21015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HED23_RS21025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HED23_RS21045	COG1716	ATPase activity
HED23_RS21065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HED23_RS21095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HED23_RS21105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HED23_RS21120	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HED23_RS21140	COG2018	Roadblock/LC7 domain
HED23_RS21175	COG0438	transferase activity, transferring glycosyl groups
HED23_RS21180	COG0438	transferase activity, transferring glycosyl groups
HED23_RS21210	COG2364	Membrane
HED23_RS21220	COG2270	Major facilitator Superfamily
HED23_RS21235	COG1216	Glycosyl transferase, family 2
HED23_RS21255	COG1960	acyl-CoA dehydrogenase activity
HED23_RS21315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HED23_RS21320	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HED23_RS21325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HED23_RS21390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HED23_RS21395	COG0140	phosphoribosyl-ATP diphosphatase activity
HED23_RS21400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HED23_RS21405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HED23_RS21405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HED23_RS21410	COG3201	nicotinamide mononucleotide transporter
HED23_RS21425	COG1846	Transcriptional regulator
HED23_RS21425	COG1940	carbohydrate kinase activity
HED23_RS21430	COG0738	Major facilitator superfamily
HED23_RS21435	COG2233	PERMEase
HED23_RS21455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HED23_RS21465	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS21480	COG2390	Transcriptional regulator
HED23_RS21485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HED23_RS21490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HED23_RS21495	COG4521	taurine ABC transporter
HED23_RS21505	COG2175	clavaminate synthase activity
HED23_RS21515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HED23_RS21530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HED23_RS21540	COG1758	RNA polymerase activity
HED23_RS21555	COG0284	orotidine-5'-phosphate decarboxylase activity
HED23_RS21560	COG0167	dihydroorotate dehydrogenase activity
HED23_RS21565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HED23_RS21570	COG0505	Belongs to the CarA family
HED23_RS21580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HED23_RS21585	COG0540	Belongs to the ATCase OTCase family
HED23_RS21590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HED23_RS21600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HED23_RS21605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HED23_RS21610	COG0006	proline dipeptidase activity
HED23_RS21620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HED23_RS21625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HED23_RS21630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HED23_RS21635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HED23_RS21640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HED23_RS21645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HED23_RS21650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HED23_RS21670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HED23_RS21690	COG0124	histidyl-tRNA synthetase
HED23_RS21705	COG1196	nuclear chromosome segregation
HED23_RS21715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HED23_RS21720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HED23_RS21725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED23_RS21730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED23_RS21740	COG2255	four-way junction helicase activity
HED23_RS21745	COG0632	four-way junction helicase activity
HED23_RS21750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HED23_RS21755	COG0217	transcriptional regulatory protein
HED23_RS21760	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HED23_RS21765	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HED23_RS21775	COG0438	transferase activity, transferring glycosyl groups
HED23_RS21780	COG1560	Kdo2-lipid A biosynthetic process
HED23_RS21785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HED23_RS21805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HED23_RS21810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HED23_RS21825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HED23_RS21850	COG0395	ABC-type sugar transport system, permease component
HED23_RS21855	COG1175	transmembrane transport
HED23_RS21890	COG1609	Transcriptional regulator
HED23_RS21905	COG0456	acetyltransferase
HED23_RS21905	COG0454	-acetyltransferase
HED23_RS21915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HED23_RS21970	COG2309	aminopeptidase activity
HED23_RS22000	COG1648	precorrin-2 dehydrogenase activity
HED23_RS22000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HED23_RS22005	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HED23_RS22020	COG1464	Belongs to the NlpA lipoprotein family
HED23_RS22025	COG2011	ABC-type metal ion transport system permease component
HED23_RS22065	COG0477	Major facilitator Superfamily
HED23_RS22085	COG0165	Argininosuccinate lyase
HED23_RS22105	COG1438	arginine binding
HED23_RS22110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HED23_RS22120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HED23_RS22125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HED23_RS22130	COG4977	sequence-specific DNA binding
HED23_RS22165	COG4585	Histidine kinase
HED23_RS22170	COG2197	response regulator
HED23_RS22175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HED23_RS22185	COG0454	-acetyltransferase
HED23_RS22185	COG0456	acetyltransferase
HED23_RS22195	COG0697	spore germination
HED23_RS22205	COG1649	PFAM Uncharacterised BCR, COG1649
HED23_RS22230	COG0513	Belongs to the DEAD box helicase family
HED23_RS22235	COG1278	Cold shock
HED23_RS22255	COG3250	beta-galactosidase activity
HED23_RS22260	COG0395	ABC-type sugar transport system, permease component
HED23_RS22265	COG1175	transmembrane transport
HED23_RS22280	COG1609	Transcriptional regulator
HED23_RS22300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED23_RS22315	COG0179	Fumarylacetoacetate (FAA) hydrolase
HED23_RS22325	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS22340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED23_RS22350	COG0179	Fumarylacetoacetate (FAA) hydrolase
HED23_RS22380	COG0072	phenylalanine-tRNA ligase activity
HED23_RS22380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HED23_RS22385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HED23_RS22390	COG5002	protein histidine kinase activity
HED23_RS22395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HED23_RS22400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HED23_RS22405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HED23_RS22410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HED23_RS22450	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS22455	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS22460	COG0174	glutamine synthetase
HED23_RS22470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HED23_RS22495	COG4176	ABC-type proline glycine betaine transport system permease component
HED23_RS22500	COG4175	Glycine betaine
HED23_RS22500	COG0517	IMP dehydrogenase activity
HED23_RS22505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HED23_RS22545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HED23_RS22550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HED23_RS22595	COG0805	protein transport
HED23_RS22600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HED23_RS22620	COG2378	regulation of single-species biofilm formation
HED23_RS22630	COG0545	Peptidyl-prolyl cis-trans isomerase
HED23_RS22635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HED23_RS22645	COG1609	Transcriptional regulator
HED23_RS22650	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HED23_RS22655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HED23_RS22665	COG4122	O-methyltransferase activity
HED23_RS22670	COG1222	aaa ATPase
HED23_RS22690	COG0517	IMP dehydrogenase activity
HED23_RS22690	COG1994	Peptidase M50
HED23_RS22700	COG2197	response regulator
HED23_RS22705	COG4166	transmembrane transport
HED23_RS22715	COG1410	methionine synthase
HED23_RS22715	COG0646	methionine synthase
HED23_RS22720	COG1414	Transcriptional regulator
HED23_RS22725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HED23_RS22730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HED23_RS22735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HED23_RS22740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS22745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS22750	COG2186	Transcriptional regulator
HED23_RS22755	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS22760	COG4948	Mandelate Racemase Muconate Lactonizing
HED23_RS22770	COG0215	cysteine-tRNA ligase activity
HED23_RS22790	COG0598	Magnesium transport protein CorA
HED23_RS22800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS22805	COG0667	Aldo Keto reductase
HED23_RS22835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HED23_RS22865	COG0564	pseudouridine synthase activity
HED23_RS22880	COG2186	Transcriptional regulator
HED23_RS22885	COG3265	gluconokinase activity
HED23_RS22920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HED23_RS22925	COG2149	membrane
HED23_RS22945	COG1960	acyl-CoA dehydrogenase activity
HED23_RS22950	COG4935	Belongs to the peptidase S8 family
HED23_RS22950	COG2234	aminopeptidase activity
HED23_RS22965	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS22975	COG3876	Protein conserved in bacteria
HED23_RS23015	COG1960	acyl-CoA dehydrogenase activity
HED23_RS23025	COG0640	Transcriptional regulator
HED23_RS23070	COG2851	Citrate transporter
HED23_RS23075	COG0243	molybdopterin cofactor binding
HED23_RS23080	COG1309	transcriptional regulator
HED23_RS23085	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HED23_RS23090	COG2188	Transcriptional regulator
HED23_RS23110	COG2755	lipolytic protein G-D-S-L family
HED23_RS23115	COG0463	Glycosyl transferase, family 2
HED23_RS23120	COG1216	Glycosyl transferase, family 2
HED23_RS23135	COG1725	Transcriptional regulator
HED23_RS23155	COG0596	Alpha beta hydrolase
HED23_RS23165	COG0346	lactoylglutathione lyase activity
HED23_RS23185	COG4565	transcriptional regulatory protein
HED23_RS23190	COG3540	Alkaline phosphatase
HED23_RS23220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HED23_RS23225	COG0587	DNA-directed DNA polymerase activity
HED23_RS23270	COG0641	radical SAM
HED23_RS23305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS23310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS23315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED23_RS23320	COG1126	abc transporter atp-binding protein
HED23_RS23335	COG0765	amino acid transport
HED23_RS23340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED23_RS23350	COG1799	cell septum assembly
HED23_RS23355	COG1960	acyl-CoA dehydrogenase activity
HED23_RS23360	COG0477	Major facilitator Superfamily
HED23_RS23365	COG0671	phosphoesterase, PA-phosphatase related
HED23_RS23375	COG0438	transferase activity, transferring glycosyl groups
HED23_RS23390	COG1160	GTP binding
HED23_RS23400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HED23_RS23425	COG3541	Predicted nucleotidyltransferase
HED23_RS23450	COG1187	pseudouridine synthase activity
HED23_RS23455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HED23_RS23460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HED23_RS23475	COG0686	Belongs to the AlaDH PNT family
HED23_RS23485	COG0494	nUDIX hydrolase
HED23_RS23490	COG0504	CTP synthase activity
HED23_RS23495	COG3387	PFAM Glycoside hydrolase 15-related
HED23_RS23515	COG0497	DNA recombination
HED23_RS23520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HED23_RS23540	COG1120	ATPase activity
HED23_RS23545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS23550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS23555	COG0647	UMP catabolic process
HED23_RS23600	COG2094	Belongs to the DNA glycosylase MPG family
HED23_RS23610	COG1881	PFAM PEBP family protein
HED23_RS23635	COG1119	ATPase activity
HED23_RS23650	COG2197	response regulator
HED23_RS23655	COG4585	Histidine kinase
HED23_RS23660	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS23665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HED23_RS23675	COG1716	ATPase activity
HED23_RS23675	COG1131	(ABC) transporter
HED23_RS23675	COG0842	Transport permease protein
HED23_RS23680	COG0560	Phosphoserine phosphatase
HED23_RS23680	COG3830	Belongs to the UPF0237 family
HED23_RS23695	COG2807	transmembrane transport
HED23_RS23700	COG2186	Transcriptional regulator
HED23_RS23710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HED23_RS23730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HED23_RS23735	COG2261	transglycosylase associated protein
HED23_RS23750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HED23_RS23755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED23_RS23795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HED23_RS23810	COG3387	PFAM Glycoside hydrolase 15-related
HED23_RS23850	COG1024	Enoyl-CoA hydratase
HED23_RS23860	COG0488	(ABC) transporter
HED23_RS23880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HED23_RS23885	COG0235	Class ii aldolase
HED23_RS23900	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HED23_RS23905	COG1492	cobalamin metabolic process
HED23_RS23920	COG1797	cobyrinic acid a,c-diamide synthase activity
HED23_RS23945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HED23_RS23960	COG1917	Cupin 2, conserved barrel domain protein
HED23_RS23990	COG0604	alcohol dehydrogenase
HED23_RS23995	COG1309	transcriptional regulator
HED23_RS24025	COG1175	transmembrane transport
HED23_RS24030	COG0395	ABC-type sugar transport system, permease component
HED23_RS24050	COG1902	pentaerythritol trinitrate reductase activity
HED23_RS24055	COG1846	Transcriptional regulator
HED23_RS24120	COG1414	Transcriptional regulator
HED23_RS24125	COG0768	penicillin binding
HED23_RS24150	COG1309	transcriptional regulator
HED23_RS24160	COG0702	epimerase
HED23_RS24195	COG0436	Aminotransferase
HED23_RS24200	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS24210	COG0519	Catalyzes the synthesis of GMP from XMP
HED23_RS24210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HED23_RS24215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HED23_RS24220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HED23_RS24225	COG0189	ligase activity
HED23_RS24240	COG1960	acyl-CoA dehydrogenase activity
HED23_RS24245	COG1960	acyl-CoA dehydrogenase activity
HED23_RS24255	COG3866	Pectate lyase
HED23_RS24260	COG2755	lipolytic protein G-D-S-L family
HED23_RS24290	COG3866	Pectate lyase
HED23_RS24295	COG0395	ABC-type sugar transport system, permease component
HED23_RS24310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED23_RS24315	COG1802	Transcriptional regulator
HED23_RS24325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED23_RS24330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HED23_RS24385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED23_RS24390	COG2171	N-acyltransferase activity
HED23_RS24400	COG3226	Transcriptional regulator
HED23_RS24405	COG2076	Multidrug Resistance protein
HED23_RS24425	COG0822	iron-sulfur transferase activity
HED23_RS24430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HED23_RS24435	COG0396	ATPase activity
HED23_RS24445	COG0719	Fe-S assembly protein
HED23_RS24480	COG0109	protoheme IX farnesyltransferase activity
HED23_RS24490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HED23_RS24505	COG0363	glucosamine-6-phosphate deaminase activity
HED23_RS24510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HED23_RS24535	COG2197	response regulator
HED23_RS24540	COG0477	Major facilitator Superfamily
HED23_RS24555	COG1960	acyl-CoA dehydrogenase activity
HED23_RS24580	COG0166	Belongs to the GPI family
HED23_RS24590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HED23_RS24595	COG0149	triose-phosphate isomerase activity
HED23_RS24600	COG0126	phosphoglycerate kinase activity
HED23_RS24605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HED23_RS24610	COG1481	regulation of sporulation
HED23_RS24615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HED23_RS24620	COG1660	Displays ATPase and GTPase activities
HED23_RS24625	COG0322	excinuclease ABC activity
HED23_RS24635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HED23_RS24665	COG0556	nucleotide-excision repair
HED23_RS24675	COG0584	glycerophosphoryl diester phosphodiesterase
HED23_RS24680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HED23_RS24690	COG2313	pseudouridylate synthase activity
HED23_RS24720	COG0436	Aminotransferase
HED23_RS24740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HED23_RS24745	COG0330	HflC and HflK could
HED23_RS24760	COG1397	ADP-ribosylglycohydrolase
HED23_RS24775	COG0237	dephospho-CoA kinase activity
HED23_RS24795	COG2226	methyltransferase
HED23_RS24800	COG1643	Atp-dependent helicase
HED23_RS24825	COG2050	protein possibly involved in aromatic compounds catabolism
HED23_RS24835	COG0559	Belongs to the binding-protein-dependent transport system permease family
HED23_RS24875	COG0737	Belongs to the 5'-nucleotidase family
HED23_RS24895	COG1605	Chorismate mutase
HED23_RS24895	COG0287	Prephenate dehydrogenase
HED23_RS24920	COG4941	Belongs to the sigma-70 factor family
HED23_RS24925	COG3795	YCII-related domain
HED23_RS24945	COG1278	Cold shock
HED23_RS24950	COG1309	transcriptional regulator
HED23_RS24965	COG0705	Rhomboid family
HED23_RS24970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HED23_RS24980	COG0069	glutamate synthase activity
HED23_RS24980	COG0067	glutamate synthase
HED23_RS24980	COG0070	glutamate synthase
HED23_RS25010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HED23_RS25015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HED23_RS25035	COG0159	tryptophan synthase activity
HED23_RS25040	COG0133	tryptophan synthase activity
HED23_RS25045	COG0134	indole-3-glycerol-phosphate synthase activity
HED23_RS25070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HED23_RS25080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED23_RS25085	COG2508	Transcriptional regulator
HED23_RS25110	COG0107	imidazoleglycerol-phosphate synthase activity
HED23_RS25115	COG0251	oxidation-reduction process
HED23_RS25120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HED23_RS25125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HED23_RS25135	COG0131	Imidazoleglycerol-phosphate dehydratase
HED23_RS25140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HED23_RS25145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HED23_RS25195	COG1432	Conserved Protein
HED23_RS25205	COG0587	DNA-directed DNA polymerase activity
HED23_RS25250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HED23_RS25260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HED23_RS25265	COG3599	regulation of cell shape
HED23_RS25275	COG1799	cell septum assembly
HED23_RS25280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HED23_RS25295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HED23_RS25300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HED23_RS25310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HED23_RS25315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HED23_RS25325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HED23_RS25330	COG0768	penicillin binding
HED23_RS25340	COG0275	rRNA processing
HED23_RS25350	COG0714	Associated with various cellular activities
HED23_RS25370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HED23_RS25380	COG1121	(ABC) transporter
HED23_RS25415	COG0352	thiamine-phosphate diphosphorylase activity
HED23_RS25435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HED23_RS25435	COG2022	thiamine diphosphate biosynthetic process
HED23_RS25445	COG2022	thiamine diphosphate biosynthetic process
HED23_RS25450	COG0515	serine threonine protein kinase
HED23_RS25450	COG2815	serine threonine protein kinase
HED23_RS25455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HED23_RS25465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HED23_RS25470	COG2193	ferroxidase activity
HED23_RS25480	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HED23_RS25500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED23_RS25505	COG0205	6-phosphofructokinase activity
HED23_RS25510	COG2197	response regulator
HED23_RS25515	COG4585	Histidine kinase
HED23_RS25540	COG1940	carbohydrate kinase activity
HED23_RS25550	COG0003	Pfam Anion-transporting ATPase
HED23_RS25570	COG0438	transferase activity, transferring glycosyl groups
HED23_RS25610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HED23_RS25615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HED23_RS25620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HED23_RS25625	COG0723	plastoquinol--plastocyanin reductase activity
HED23_RS25630	COG2010	Cytochrome c
HED23_RS25635	COG1845	cytochrome c oxidase, subunit III
HED23_RS25645	COG1376	ErfK ybiS ycfS ynhG family protein
HED23_RS25655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HED23_RS25660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HED23_RS25670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HED23_RS25690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HED23_RS25695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HED23_RS25700	COG2197	response regulator
HED23_RS25705	COG4585	Histidine kinase
HED23_RS25730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HED23_RS25745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HED23_RS25755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HED23_RS25760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HED23_RS25765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HED23_RS25770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HED23_RS25780	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HED23_RS25815	COG0321	lipoyl(octanoyl) transferase activity
HED23_RS25820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HED23_RS25900	COG0745	RESPONSE REGULATOR receiver
HED23_RS25905	COG4585	Histidine kinase
HED23_RS25910	COG2197	response regulator
HED23_RS25930	COG1309	transcriptional regulator
HED23_RS26000	COG0366	Alpha amylase catalytic
HED23_RS26005	COG0395	ABC-type sugar transport system, permease component
HED23_RS26020	COG1609	Transcriptional regulator
HED23_RS26030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HED23_RS26040	COG2890	protein-(glutamine-N5) methyltransferase activity
HED23_RS26065	COG0738	Major facilitator superfamily
HED23_RS26085	COG0174	glutamine synthetase
HED23_RS26105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HED23_RS26105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HED23_RS26115	COG0667	Aldo Keto reductase
HED23_RS26125	COG2814	Major facilitator Superfamily
HED23_RS26140	COG1309	transcriptional regulator
HED23_RS26145	COG0477	Major facilitator Superfamily
HED23_RS26150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HED23_RS26170	COG1994	Peptidase M50
HED23_RS26215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED23_RS26220	COG1120	ATPase activity
HED23_RS26270	COG2814	Major facilitator Superfamily
HED23_RS26280	COG3540	Alkaline phosphatase
HED23_RS26295	COG0384	phenazine biosynthesis protein PhzF
HED23_RS26305	COG1309	transcriptional regulator
HED23_RS26335	COG2124	cytochrome p450
HED23_RS26375	COG0557	exoribonuclease II activity
HED23_RS26380	COG3022	response to hydroperoxide
HED23_RS26385	COG0800	Aldolase
HED23_RS26405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HED23_RS26410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HED23_RS26430	COG0477	Major facilitator Superfamily
HED23_RS26435	COG3340	Belongs to the peptidase S51 family
HED23_RS26450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HED23_RS26455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HED23_RS26500	COG0438	transferase activity, transferring glycosyl groups
HED23_RS26505	COG1309	transcriptional regulator
HED23_RS26525	COG0559	Belongs to the binding-protein-dependent transport system permease family
HED23_RS26545	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS26560	COG1657	PFAM Prenyltransferase squalene oxidase
HED23_RS26575	COG3845	ABC transporter
HED23_RS26585	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HED23_RS26585	COG1082	Xylose isomerase domain protein TIM barrel
HED23_RS26590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HED23_RS26595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HED23_RS26605	COG0477	Major facilitator Superfamily
HED23_RS26655	COG2259	Doxx family
HED23_RS26775	COG1358	cellular component organization or biogenesis
HED23_RS26820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HED23_RS26830	COG0477	Major facilitator Superfamily
HED23_RS26850	COG4585	Histidine kinase
HED23_RS26855	COG2197	response regulator
HED23_RS26870	COG2197	response regulator
HED23_RS26880	COG1131	(ABC) transporter
HED23_RS26900	COG0667	Aldo Keto reductase
HED23_RS26905	COG0789	Transcriptional regulator
HED23_RS26945	COG1695	Transcriptional regulator
HED23_RS26970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HED23_RS26975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED23_RS26980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED23_RS27020	COG1231	oxidoreductase activity
HED23_RS27025	COG1280	lysine exporter protein (LysE YggA)
HED23_RS27055	COG1129	ABC transporter
HED23_RS27060	COG4214	carbohydrate transport
HED23_RS27080	COG1764	response to oxidative stress
HED23_RS27090	COG2130	NADP-dependent
HED23_RS27120	COG1522	sequence-specific DNA binding
HED23_RS27145	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS27150	COG0825	malonyl-CoA metabolic process
HED23_RS27150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HED23_RS27160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS27200	COG0300	oxidoreductase activity
HED23_RS27200	COG0318	PFAM AMP-dependent synthetase and ligase
HED23_RS27200	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS27200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS27200	COG3321	synthase
HED23_RS27210	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HED23_RS27215	COG1132	(ABC) transporter
HED23_RS27225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED23_RS27230	COG0583	DNA-binding transcription factor activity
HED23_RS27235	COG0697	spore germination
HED23_RS27240	COG2267	carboxylic ester hydrolase activity
HED23_RS27255	COG3629	intracellular signal transduction
HED23_RS27255	COG3903	Transcriptional regulator
HED23_RS27275	COG2755	lipolytic protein G-D-S-L family
HED23_RS27310	COG4585	Histidine kinase
HED23_RS27315	COG2197	response regulator
HED23_RS27350	COG3118	belongs to the thioredoxin family
HED23_RS27355	COG0492	ferredoxin-NADP+ reductase activity
HED23_RS27360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HED23_RS27370	COG0798	PFAM Bile acid sodium symporter
HED23_RS27375	COG2072	flavoprotein involved in K transport
HED23_RS27385	COG0640	Transcriptional regulator
HED23_RS27390	COG2072	flavoprotein involved in K transport
HED23_RS27450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HED23_RS27485	COG1007	ATP synthesis coupled electron transport
HED23_RS27495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HED23_RS27500	COG0713	ATP synthesis coupled electron transport
HED23_RS27510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HED23_RS27520	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED23_RS27585	COG1228	amidohydrolase
HED23_RS27620	COG1484	DNA-dependent DNA replication
HED23_RS27650	COG0791	NLP P60 protein
HED23_RS27650	COG3883	PFAM NLP P60 protein
HED23_RS27760	COG0789	Transcriptional regulator
HED23_RS27765	COG1742	UPF0060 membrane protein
HED23_RS27870	COG0582	viral genome integration into host DNA
HED23_RS27895	COG1070	Carbohydrate kinase
HED23_RS27915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HED23_RS27920	COG0358	DNA primase activity
HED23_RS27930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HED23_RS27940	COG2949	membrane
HED23_RS27945	COG0243	molybdopterin cofactor binding
HED23_RS27990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED23_RS27995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED23_RS27995	COG2146	nitrite reductase [NAD(P)H] activity
HED23_RS28025	COG0574	Belongs to the PEP-utilizing enzyme family
HED23_RS28025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HED23_RS28045	COG0423	glycine-tRNA ligase activity
HED23_RS28060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HED23_RS28070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HED23_RS28075	COG1381	Involved in DNA repair and RecF pathway recombination
HED23_RS28080	COG2197	response regulator
HED23_RS28085	COG4585	Histidine kinase
HED23_RS28090	COG2409	Drug exporters of the RND superfamily
HED23_RS28100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HED23_RS28115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HED23_RS28125	COG2315	Protein conserved in bacteria
HED23_RS28135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HED23_RS28145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HED23_RS28145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HED23_RS28155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HED23_RS28160	COG1234	tRNA 3'-trailer cleavage
HED23_RS28165	COG0537	adenosine 5'-monophosphoramidase activity
HED23_RS28180	COG0484	heat shock protein binding
HED23_RS28185	COG1420	regulation of RNA biosynthetic process
HED23_RS28220	COG0481	GTPase activity
HED23_RS28225	COG0268	Binds directly to 16S ribosomal RNA
HED23_RS28245	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HED23_RS28265	COG1555	photosystem II stabilization
HED23_RS28270	COG1307	EDD domain protein, DegV family
HED23_RS28280	COG0495	leucyl-tRNA aminoacylation
HED23_RS28310	COG0588	phosphoglycerate mutase activity
HED23_RS28315	COG0799	negative regulation of ribosome biogenesis
HED23_RS28325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HED23_RS28340	COG0501	Belongs to the peptidase M48B family
HED23_RS28355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HED23_RS28365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HED23_RS28390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HED23_RS28395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HED23_RS28400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HED23_RS28445	COG0438	transferase activity, transferring glycosyl groups
HED23_RS28460	COG0438	transferase activity, transferring glycosyl groups
HED23_RS28470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HED23_RS28485	COG0673	inositol 2-dehydrogenase activity
HED23_RS28495	COG1530	ribonuclease E activity
HED23_RS28525	COG0772	Belongs to the SEDS family
HED23_RS28545	COG1077	Cell shape determining protein MreB Mrl
HED23_RS28550	COG0105	UTP biosynthetic process
HED23_RS28560	COG0285	dihydrofolate synthase activity
HED23_RS28565	COG0525	valine-tRNA ligase activity
HED23_RS28575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HED23_RS28580	COG0740	serine-type endopeptidase activity
HED23_RS28585	COG0740	serine-type endopeptidase activity
HED23_RS28590	COG0544	peptidyl-prolyl cis-trans isomerase activity
HED23_RS28620	COG3594	Acyltransferase
HED23_RS28630	COG0475	glutathione-regulated potassium exporter activity
HED23_RS28640	COG4552	Acetyltransferase involved in intracellular survival and related
HED23_RS28655	COG1113	amino acid transport
HED23_RS28670	COG1113	amino acid transport
HED23_RS28675	COG1113	amino acid transport
HED23_RS28680	COG0584	glycerophosphoryl diester phosphodiesterase
HED23_RS28685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HED23_RS28695	COG2211	Major facilitator Superfamily
HED23_RS28705	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HED23_RS28740	COG4266	Belongs to the allantoicase family
HED23_RS28765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HED23_RS28765	COG3291	Pkd domain containing protein
HED23_RS28775	COG0668	transmembrane transport
HED23_RS28780	COG1940	carbohydrate kinase activity
HED23_RS28780	COG1846	Transcriptional regulator
HED23_RS28785	COG1653	transport
HED23_RS28790	COG1175	transmembrane transport
HED23_RS28795	COG0395	ABC-type sugar transport system, permease component
HED23_RS28800	COG1486	melibiose metabolic process
HED23_RS28815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED23_RS28845	COG2346	COG2346, Truncated hemoglobins
HED23_RS28860	COG1136	(ABC) transporter
HED23_RS28860	COG0577	efflux transmembrane transporter activity
HED23_RS28885	COG0629	single-stranded DNA binding
HED23_RS28945	COG1129	ABC transporter
HED23_RS28955	COG1172	Belongs to the binding-protein-dependent transport system permease family
HED23_RS28965	COG3254	rhamnose metabolic process
HED23_RS29000	COG0456	acetyltransferase
HED23_RS29000	COG0454	-acetyltransferase
HED23_RS29005	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS29025	COG3962	Belongs to the TPP enzyme family
HED23_RS29030	COG3718	enzyme involved in inositol metabolism
HED23_RS29060	COG2409	Drug exporters of the RND superfamily
HED23_RS29085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HED23_RS29135	COG0500	methyltransferase
HED23_RS29155	COG1733	regulation of RNA biosynthetic process
HED23_RS29175	COG0673	inositol 2-dehydrogenase activity
HED23_RS29180	COG1609	Transcriptional regulator
HED23_RS29200	COG3903	Transcriptional regulator
HED23_RS29200	COG3629	intracellular signal transduction
HED23_RS29240	COG1404	Belongs to the peptidase S8 family
HED23_RS29265	COG1472	Belongs to the glycosyl hydrolase 3 family
HED23_RS29295	COG0028	Belongs to the TPP enzyme family
HED23_RS29305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED23_RS29370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HED23_RS29375	COG1175	transmembrane transport
HED23_RS29380	COG0395	ABC-type sugar transport system, permease component
HED23_RS29385	COG1609	Transcriptional regulator
HED23_RS29390	COG1874	Beta-galactosidase
HED23_RS29420	COG1946	Acyl-CoA thioesterase
HED23_RS29450	COG2124	cytochrome p450
HED23_RS29470	COG1309	transcriptional regulator
HED23_RS29475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HED23_RS29490	COG1960	acyl-CoA dehydrogenase activity
HED23_RS29530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HED23_RS29535	COG0589	response to stress
HED23_RS29540	COG4977	sequence-specific DNA binding
HED23_RS29630	COG0395	ABC-type sugar transport system, permease component
HED23_RS29655	COG0745	RESPONSE REGULATOR receiver
HED23_RS29670	COG0667	Aldo Keto reductase
HED23_RS29680	COG1216	Glycosyl transferase, family 2
HED23_RS29680	COG1442	glycosyl transferase family 8
HED23_RS29690	COG0438	transferase activity, transferring glycosyl groups
HED23_RS29700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HED23_RS29705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HED23_RS29715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HED23_RS29720	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HED23_RS29735	COG0588	phosphoglycerate mutase activity
HED23_RS29780	COG5001	Diguanylate cyclase
HED23_RS29780	COG3300	MHYT domain
HED23_RS29785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS29795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED23_RS29800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED23_RS29805	COG0765	amino acid transport
HED23_RS29810	COG0765	amino acid transport
HED23_RS29815	COG1126	abc transporter atp-binding protein
HED23_RS29830	COG3397	chitin binding
HED23_RS29875	COG0583	DNA-binding transcription factor activity
HED23_RS29910	COG0673	inositol 2-dehydrogenase activity
HED23_RS29915	COG4702	Belongs to the UPF0303 family
HED23_RS29920	COG0179	Fumarylacetoacetate (FAA) hydrolase
HED23_RS29925	COG0706	membrane insertase activity
HED23_RS29975	COG0477	Major facilitator Superfamily
HED23_RS29980	COG2188	Transcriptional regulator
HED23_RS29985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HED23_RS30095	COG3851	Histidine kinase
HED23_RS30135	COG2365	Tyrosine phosphatase family
HED23_RS30140	COG2197	response regulator
HED23_RS30145	COG4585	Histidine kinase
HED23_RS30150	COG2409	Drug exporters of the RND superfamily
HED23_RS30155	COG3708	Transcriptional regulator
HED23_RS30155	COG2207	Transcriptional regulator
HED23_RS30165	COG0477	Major facilitator Superfamily
HED23_RS30185	COG1309	transcriptional regulator
HED23_RS30190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HED23_RS30215	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HED23_RS30225	COG0191	fructose-bisphosphate aldolase activity
HED23_RS30230	COG1349	DNA-binding transcription factor activity
HED23_RS30240	COG0137	argininosuccinate synthase activity
HED23_RS30250	COG2733	membrane
HED23_RS30305	COG0477	Major facilitator Superfamily
HED23_RS30350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HED23_RS30360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HED23_RS30365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED23_RS30370	COG1263	PTS System
HED23_RS30375	COG1263	PTS System
HED23_RS30380	COG1234	tRNA 3'-trailer cleavage
HED23_RS30405	COG1113	amino acid transport
HED23_RS30415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HED23_RS30425	COG1335	isochorismatase
HED23_RS30460	COG0277	FAD linked oxidase domain protein
HED23_RS30470	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HED23_RS30480	COG1174	glycine betaine transport
HED23_RS30490	COG1174	glycine betaine transport
HED23_RS30555	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS30595	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HED23_RS30600	COG0395	ABC-type sugar transport system, permease component
HED23_RS30605	COG1175	transmembrane transport
HED23_RS30620	COG1678	Uncharacterized ACR, COG1678
HED23_RS30625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HED23_RS30630	COG0776	regulation of translation
HED23_RS30640	COG3973	AAA domain
HED23_RS30675	COG2223	nitrite transmembrane transporter activity
HED23_RS30695	COG0583	DNA-binding transcription factor activity
HED23_RS30710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HED23_RS30715	COG0793	Belongs to the peptidase S41A family
HED23_RS30720	COG2177	Part of the ABC transporter FtsEX involved in
HED23_RS30725	COG2884	Cell division ATP-binding protein ftsE
HED23_RS30740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HED23_RS30745	COG0515	serine threonine protein kinase
HED23_RS30750	COG0515	serine threonine protein kinase
HED23_RS30755	COG1674	ftsk spoiiie
HED23_RS30760	COG1653	transport
HED23_RS30765	COG1175	transmembrane transport
HED23_RS30770	COG0395	ABC-type sugar transport system, permease component
HED23_RS30775	COG0463	Glycosyl transferase, family 2
HED23_RS30775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HED23_RS30780	COG0438	transferase activity, transferring glycosyl groups
HED23_RS30785	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HED23_RS30790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HED23_RS30800	COG2226	methyltransferase
HED23_RS30800	COG1073	alpha beta
HED23_RS30805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HED23_RS30820	COG1309	transcriptional regulator
HED23_RS30830	COG1134	teichoic acid transport
HED23_RS30835	COG2902	Dehydrogenase
HED23_RS30855	COG0653	protein targeting
HED23_RS30870	COG2197	response regulator
HED23_RS30875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HED23_RS30880	COG1040	competence protein
HED23_RS30885	COG0823	Involved in the tonB-independent uptake of proteins
HED23_RS30890	COG5002	protein histidine kinase activity
HED23_RS30895	COG0745	RESPONSE REGULATOR receiver
HED23_RS30900	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HED23_RS30920	COG0714	Associated with various cellular activities
HED23_RS30960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HED23_RS30970	COG1482	cell wall glycoprotein biosynthetic process
HED23_RS30980	COG2835	tetraacyldisaccharide 4'-kinase activity
HED23_RS30985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HED23_RS30990	COG1620	l-lactate permease
HED23_RS31025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HED23_RS31030	COG0778	Nitroreductase
HED23_RS31030	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HED23_RS31040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HED23_RS31055	COG1316	TRANSCRIPTIONal
HED23_RS31070	COG1316	TRANSCRIPTIONal
HED23_RS31085	COG1316	TRANSCRIPTIONal
HED23_RS31120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HED23_RS31145	COG2205	protein histidine kinase activity
HED23_RS31150	COG0745	RESPONSE REGULATOR receiver
HED23_RS31155	COG3104	oligopeptide transport
HED23_RS31165	COG1366	Belongs to the anti-sigma-factor antagonist family
HED23_RS31170	COG1191	sigma factor activity
HED23_RS31175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HED23_RS31215	COG1228	amidohydrolase
HED23_RS31225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HED23_RS31230	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HED23_RS31290	COG2755	lipolytic protein G-D-S-L family
HED23_RS31295	COG0183	Belongs to the thiolase family
HED23_RS31330	COG4608	Belongs to the ABC transporter superfamily
HED23_RS31335	COG0444	Belongs to the ABC transporter superfamily
HED23_RS31345	COG0601	transmembrane transport
HED23_RS31355	COG1609	Transcriptional regulator
HED23_RS31360	COG1136	(ABC) transporter
HED23_RS31360	COG0577	efflux transmembrane transporter activity
HED23_RS31365	COG1136	(ABC) transporter
HED23_RS31365	COG0577	efflux transmembrane transporter activity
HED23_RS31370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HED23_RS31375	COG1252	NADH dehydrogenase
HED23_RS31400	COG0148	phosphopyruvate hydratase activity
HED23_RS31415	COG2124	cytochrome p450
HED23_RS31430	COG0515	serine threonine protein kinase
HED23_RS31430	COG2815	serine threonine protein kinase
HED23_RS31480	COG0577	efflux transmembrane transporter activity
HED23_RS31485	COG1136	(ABC) transporter
HED23_RS31490	COG0477	Major facilitator Superfamily
HED23_RS31500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED23_RS31530	COG4585	Histidine kinase
HED23_RS31545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HED23_RS31550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HED23_RS31555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HED23_RS31560	COG0193	aminoacyl-tRNA hydrolase activity
HED23_RS31570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HED23_RS31590	COG4106	trans-aconitate 2-methyltransferase activity
HED23_RS31595	COG1846	Transcriptional regulator
HED23_RS31600	COG2197	response regulator
HED23_RS31610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HED23_RS31625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED23_RS31660	COG0488	(ABC) transporter
HED23_RS31680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HED23_RS31685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HED23_RS31695	COG0084	hydrolase, TatD family'
HED23_RS31715	COG1309	transcriptional regulator
HED23_RS31740	COG3845	ABC transporter
HED23_RS31745	COG4603	Belongs to the binding-protein-dependent transport system permease family
HED23_RS31750	COG1079	Belongs to the binding-protein-dependent transport system permease family
HED23_RS31760	COG0442	prolyl-tRNA aminoacylation
HED23_RS31785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HED23_RS31790	COG1122	ATPase activity
HED23_RS31800	COG0310	cobalt ion transport
HED23_RS31810	COG2409	Drug exporters of the RND superfamily
HED23_RS31820	COG0793	Belongs to the peptidase S41A family
HED23_RS31820	COG4946	Tricorn protease homolog
HED23_RS31830	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS31840	COG2072	flavoprotein involved in K transport
HED23_RS31900	COG0521	Mo-molybdopterin cofactor biosynthetic process
HED23_RS31900	COG0315	cyclic pyranopterin monophosphate synthase activity
HED23_RS31905	COG0315	cyclic pyranopterin monophosphate synthase activity
HED23_RS31915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HED23_RS31920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HED23_RS31925	COG2366	antibiotic biosynthetic process
HED23_RS31930	COG3263	regulation of cellular component size
HED23_RS31945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HED23_RS31955	COG1970	mechanosensitive ion channel activity
HED23_RS31980	COG0243	molybdopterin cofactor binding
HED23_RS32015	COG1247	-acetyltransferase
HED23_RS32020	COG3384	dioxygenase
HED23_RS32025	COG1846	Transcriptional regulator
HED23_RS32115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HED23_RS32135	COG1902	pentaerythritol trinitrate reductase activity
HED23_RS32140	COG0789	Transcriptional regulator
HED23_RS32145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HED23_RS32155	COG2186	Transcriptional regulator
HED23_RS32165	COG2376	Dihydroxyacetone kinase
HED23_RS32170	COG0698	ribose 5-phosphate isomerase
HED23_RS32175	COG0149	triose-phosphate isomerase activity
HED23_RS32180	COG1082	Xylose isomerase domain protein TIM barrel
HED23_RS32185	COG2084	Dehydrogenase
HED23_RS32195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED23_RS32205	COG0768	penicillin binding
HED23_RS32230	COG0183	Belongs to the thiolase family
HED23_RS32235	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS32245	COG1309	transcriptional regulator
HED23_RS32255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HED23_RS32290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HED23_RS32305	COG0163	prenyltransferase activity
HED23_RS32315	COG0109	protoheme IX farnesyltransferase activity
HED23_RS32320	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HED23_RS32340	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS32345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HED23_RS32350	COG1333	cytochrome c biogenesis protein
HED23_RS32355	COG0785	Cytochrome C biogenesis protein
HED23_RS32360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HED23_RS32370	COG0406	alpha-ribazole phosphatase activity
HED23_RS32375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HED23_RS32410	COG2770	Histidine kinase
HED23_RS32410	COG2208	phosphoserine phosphatase activity
HED23_RS32440	COG1742	UPF0060 membrane protein
HED23_RS32455	COG1690	Belongs to the RtcB family
HED23_RS32475	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HED23_RS32480	COG0018	arginyl-trna synthetase
HED23_RS32490	COG1595	DNA-templated transcription, initiation
HED23_RS32495	COG2124	cytochrome p450
HED23_RS32515	COG2018	Roadblock/LC7 domain
HED23_RS32580	COG0113	porphobilinogen synthase activity
HED23_RS32585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HED23_RS32585	COG1648	precorrin-2 dehydrogenase activity
HED23_RS32590	COG0181	hydroxymethylbilane synthase activity
HED23_RS32595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HED23_RS32600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HED23_RS32650	COG0123	including yeast histone deacetylase and acetoin utilization protein
HED23_RS32655	COG2223	nitrite transmembrane transporter activity
HED23_RS32660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED23_RS32690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HED23_RS32700	COG0842	Transport permease protein
HED23_RS32700	COG1129	ABC transporter
HED23_RS32720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HED23_RS32720	COG0515	serine threonine protein kinase
HED23_RS32725	COG0129	dihydroxy-acid dehydratase activity
HED23_RS32740	COG1082	Xylose isomerase domain protein TIM barrel
HED23_RS32745	COG0248	Ppx GppA phosphatase
HED23_RS32765	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HED23_RS32775	COG1194	a g-specific adenine glycosylase
HED23_RS32780	COG1595	DNA-templated transcription, initiation
HED23_RS32790	COG0745	RESPONSE REGULATOR receiver
HED23_RS32795	COG2205	protein histidine kinase activity
HED23_RS32800	COG0477	Major facilitator Superfamily
HED23_RS32805	COG1309	transcriptional regulator
HED23_RS32810	COG0739	heme binding
HED23_RS32820	COG0789	Transcriptional regulator
HED23_RS32840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HED23_RS32860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HED23_RS32870	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HED23_RS32875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HED23_RS32895	COG0640	Transcriptional regulator
HED23_RS32900	COG1660	Displays ATPase and GTPase activities
HED23_RS32905	COG2197	response regulator
HED23_RS32920	COG0649	NAD binding
HED23_RS32930	COG1732	Glycine betaine
HED23_RS32935	COG1174	glycine betaine transport
HED23_RS32940	COG1174	glycine betaine transport
HED23_RS32945	COG1125	glycine betaine transport
HED23_RS32945	COG0517	IMP dehydrogenase activity
HED23_RS32960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HED23_RS32980	COG0302	gtp cyclohydrolase
HED23_RS32995	COG0037	tRNA processing
HED23_RS33005	COG2027	D-alanyl-D-alanine carboxypeptidase
HED23_RS33010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HED23_RS33025	COG0393	Putative heavy-metal-binding
HED23_RS33030	COG0655	NAD(P)H dehydrogenase (quinone) activity
HED23_RS33035	COG0076	glutamate decarboxylase activity
HED23_RS33055	COG2318	DinB family
HED23_RS33060	COG1012	belongs to the aldehyde dehydrogenase family
HED23_RS33100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HED23_RS33100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HED23_RS33135	COG1136	(ABC) transporter
HED23_RS33135	COG0577	efflux transmembrane transporter activity
HED23_RS33140	COG0577	efflux transmembrane transporter activity
HED23_RS33145	COG2897	thiosulfate sulfurtransferase activity
HED23_RS33160	COG3629	intracellular signal transduction
HED23_RS33160	COG3903	Transcriptional regulator
HED23_RS33180	COG2264	protein methyltransferase activity
HED23_RS33185	COG1181	Belongs to the D-alanine--D-alanine ligase family
HED23_RS33205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HED23_RS33210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HED23_RS33215	COG1754	DNA topoisomerase type I activity
HED23_RS33215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HED23_RS33225	COG2890	protein-(glutamine-N5) methyltransferase activity
HED23_RS33235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HED23_RS33245	COG1366	Belongs to the anti-sigma-factor antagonist family
HED23_RS33250	COG1111	helicase
HED23_RS33250	COG1205	dead DEAH box helicase
HED23_RS33310	COG0288	reversible hydration of carbon dioxide
HED23_RS33315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HED23_RS33320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HED23_RS33330	COG2267	carboxylic ester hydrolase activity
HED23_RS33355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HED23_RS33380	COG0003	Pfam Anion-transporting ATPase
HED23_RS33390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HED23_RS33400	COG1610	YqeY-like protein
HED23_RS33405	COG1408	metallophosphoesterase
HED23_RS33430	COG1609	Transcriptional regulator
HED23_RS33465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HED23_RS33540	COG0326	Molecular chaperone. Has ATPase activity
HED23_RS33545	COG2755	lipolytic protein G-D-S-L family
HED23_RS33555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HED23_RS33575	COG1595	DNA-templated transcription, initiation
HED23_RS33595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HED23_RS33600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HED23_RS33615	COG1802	Transcriptional regulator
HED23_RS33620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HED23_RS33625	COG0693	protein deglycase activity
HED23_RS33655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HED23_RS33660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HED23_RS33675	COG1131	(ABC) transporter
HED23_RS33680	COG3559	Exporter of polyketide antibiotics
HED23_RS33690	COG2124	cytochrome p450
HED23_RS33695	COG2197	response regulator
HED23_RS33700	COG4585	Histidine kinase
HED23_RS33710	COG3844	kynureninase activity
HED23_RS33725	COG0477	Major facilitator Superfamily
HED23_RS33730	COG0191	fructose-bisphosphate aldolase activity
HED23_RS33735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HED23_RS33750	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HED23_RS33780	COG0542	response to heat
HED23_RS33810	COG0789	Transcriptional regulator
HED23_RS33815	COG0484	heat shock protein binding
HED23_RS33820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HED23_RS33825	COG0443	Heat shock 70 kDa protein
HED23_RS33830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HED23_RS33835	COG0247	lactate metabolic process
HED23_RS33835	COG2181	nitrate reductase activity
HED23_RS33845	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HED23_RS33850	COG0717	Belongs to the dCTP deaminase family
HED23_RS33885	COG3209	COG3209 Rhs family protein
HED23_RS33920	COG2770	Histidine kinase
HED23_RS33920	COG2208	phosphoserine phosphatase activity
HED23_RS33930	COG4251	negative regulation of phosphorylation
HED23_RS33955	COG1733	regulation of RNA biosynthetic process
HED23_RS34015	COG3401	FG-GAP repeat protein
HED23_RS34015	COG2755	lipolytic protein G-D-S-L family
HED23_RS34020	COG0488	(ABC) transporter
HED23_RS34035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED23_RS34120	COG3594	Acyltransferase
HED23_RS34130	COG0513	Belongs to the DEAD box helicase family
HED23_RS34135	COG1278	Cold shock
HED23_RS34175	COG1585	Membrane protein implicated in regulation of membrane protease activity
HED23_RS34180	COG2268	Band 7 protein
HED23_RS34200	COG0490	domain, Protein
HED23_RS34205	COG0475	glutathione-regulated potassium exporter activity
HED23_RS34240	COG2255	four-way junction helicase activity
HED23_RS34250	COG0180	Tryptophanyl-tRNA synthetase
HED23_RS34255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED23_RS34295	COG0604	alcohol dehydrogenase
HED23_RS34320	COG2205	protein histidine kinase activity
HED23_RS34325	COG0745	RESPONSE REGULATOR receiver
HED23_RS34330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HED23_RS34345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HED23_RS34360	COG1741	Belongs to the pirin family
HED23_RS34370	COG1960	acyl-CoA dehydrogenase activity
HED23_RS34385	COG1362	aminopeptidase activity
HED23_RS34415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HED23_RS34465	COG0508	dehydrogenase complex catalyzes the overall conversion of
HED23_RS34470	COG0022	dehydrogenase e1 component
HED23_RS34495	COG0515	serine threonine protein kinase
HED23_RS34500	COG0515	serine threonine protein kinase
HED23_RS34515	COG4591	ABC-type transport system involved in lipoprotein release permease component
HED23_RS34515	COG1136	(ABC) transporter
HED23_RS34530	COG3321	synthase
HED23_RS34530	COG1028	Short-chain dehydrogenase reductase Sdr
HED23_RS34530	COG0604	alcohol dehydrogenase
HED23_RS34535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HED23_RS34565	COG1522	sequence-specific DNA binding
HED23_RS34570	COG1309	transcriptional regulator
HED23_RS34595	COG3396	Phenylacetate-CoA oxygenase
HED23_RS34600	COG3460	Phenylacetate-CoA oxygenase
HED23_RS34605	COG3396	Phenylacetate-CoA oxygenase
HED23_RS34610	COG2151	metal-sulfur cluster biosynthetic enzyme
HED23_RS34615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HED23_RS34635	COG1733	regulation of RNA biosynthetic process
HED23_RS34640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HED23_RS34650	COG1716	ATPase activity
HED23_RS34655	COG1716	ATPase activity
HED23_RS34670	COG0768	penicillin binding
HED23_RS34675	COG0515	serine threonine protein kinase
HED23_RS34680	COG3764	Sortase (surface protein transpeptidase)
HED23_RS34685	COG3764	Sortase (surface protein transpeptidase)
HED23_RS34710	COG0705	Rhomboid family
HED23_RS34725	COG2367	Beta-lactamase
HED23_RS34730	COG0768	penicillin binding
HED23_RS34735	COG0583	DNA-binding transcription factor activity
HED23_RS34755	COG0515	serine threonine protein kinase
HED23_RS34785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HED23_RS34790	COG2188	Transcriptional regulator
HED23_RS34840	COG0582	viral genome integration into host DNA
HED23_RS34855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HED23_RS34865	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HED23_RS34870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HED23_RS34875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HED23_RS34880	COG0592	DNA-directed DNA polymerase activity