locus-tag	class	description
SPRI_RS00085	COG0420	3'-5' exonuclease activity
SPRI_RS00090	COG0419	ATPase involved in DNA repair
SPRI_RS00185	COG0419	ATPase involved in DNA repair
SPRI_RS00190	COG0420	3'-5' exonuclease activity
SPRI_RS00240	COG0305	Participates in initiation and elongation during chromosome replication
SPRI_RS00300	COG2318	DinB family
SPRI_RS00325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_RS00350	COG0395	ABC-type sugar transport system, permease component
SPRI_RS00380	COG1278	Cold shock
SPRI_RS00415	COG0789	Transcriptional regulator
SPRI_RS00430	COG1695	Transcriptional regulator
SPRI_RS00445	COG1309	transcriptional regulator
SPRI_RS00525	COG4941	Belongs to the sigma-70 factor family
SPRI_RS00530	COG3795	YCII-related domain
SPRI_RS00535	COG2207	Transcriptional regulator
SPRI_RS00540	COG2223	nitrite transmembrane transporter activity
SPRI_RS00555	COG0513	Belongs to the DEAD box helicase family
SPRI_RS00575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_RS00590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPRI_RS00615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_RS00675	COG0110	maltose O-acetyltransferase activity
SPRI_RS00690	COG2132	Multicopper oxidase
SPRI_RS00715	COG0134	indole-3-glycerol-phosphate synthase activity
SPRI_RS00720	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SPRI_RS00725	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS00730	COG0662	Cupin 2, conserved barrel domain protein
SPRI_RS00735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_RS00750	COG2030	dehydratase
SPRI_RS00760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS00765	COG0156	8-amino-7-oxononanoate synthase activity
SPRI_RS00780	COG2072	flavoprotein involved in K transport
SPRI_RS00795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS00810	COG0596	Alpha beta hydrolase
SPRI_RS00865	COG0646	methionine synthase
SPRI_RS00865	COG1410	methionine synthase
SPRI_RS00870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS00875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPRI_RS00905	COG3251	PFAM MbtH domain protein
SPRI_RS00925	COG1024	Enoyl-CoA hydratase
SPRI_RS00935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_RS00940	COG2197	response regulator
SPRI_RS00980	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS01005	COG0702	epimerase
SPRI_RS01020	COG3265	gluconokinase activity
SPRI_RS01025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPRI_RS01040	COG2706	6-phosphogluconolactonase activity
SPRI_RS01055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_RS01065	COG1063	alcohol dehydrogenase
SPRI_RS01070	COG0702	epimerase
SPRI_RS01080	COG0135	phosphoribosylanthranilate isomerase activity
SPRI_RS01090	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS01095	COG0662	Cupin 2, conserved barrel domain protein
SPRI_RS01100	COG0159	tryptophan synthase activity
SPRI_RS01105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_RS01115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_RS01135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_RS01160	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SPRI_RS01180	COG1024	Enoyl-CoA hydratase
SPRI_RS01190	COG3425	synthase
SPRI_RS01195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS01270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS01280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS01295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS01315	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS01350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS01395	COG3629	intracellular signal transduction
SPRI_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS01420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_RS01420	COG4221	oxidoreductase activity
SPRI_RS01420	COG3321	synthase
SPRI_RS01425	COG1024	Enoyl-CoA hydratase
SPRI_RS01435	COG3425	synthase
SPRI_RS01440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS01445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS01450	COG4221	oxidoreductase activity
SPRI_RS01450	COG3321	synthase
SPRI_RS01450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS01450	COG0300	oxidoreductase activity
SPRI_RS01455	COG3321	synthase
SPRI_RS01455	COG0300	oxidoreductase activity
SPRI_RS01455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS01455	COG4221	oxidoreductase activity
SPRI_RS01460	COG0022	dehydrogenase e1 component
SPRI_RS01470	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_RS01475	COG1605	Chorismate mutase
SPRI_RS01480	COG0287	Prephenate dehydrogenase
SPRI_RS01485	COG0512	Glutamine amidotransferase of anthranilate synthase
SPRI_RS01485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPRI_RS01490	COG2124	cytochrome p450
SPRI_RS01495	COG2423	ornithine cyclodeaminase activity
SPRI_RS01500	COG1021	2,3-dihydroxybenzoate-AMP ligase
SPRI_RS01505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPRI_RS01515	COG0477	Major facilitator Superfamily
SPRI_RS01520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_RS01575	COG0789	Transcriptional regulator
SPRI_RS01585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPRI_RS01610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPRI_RS01625	COG0531	amino acid
SPRI_RS01630	COG0667	Aldo Keto reductase
SPRI_RS01690	COG0277	FAD linked oxidase domain protein
SPRI_RS01695	COG1597	lipid kinase activity
SPRI_RS01705	COG0346	lactoylglutathione lyase activity
SPRI_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS01740	COG1982	Orn Lys Arg decarboxylase major
SPRI_RS01780	COG1609	Transcriptional regulator
SPRI_RS01820	COG0463	Glycosyl transferase, family 2
SPRI_RS01835	COG1309	transcriptional regulator
SPRI_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS01875	COG4770	biotin carboxylase activity
SPRI_RS01880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS01880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS01885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_RS01890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS01890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS01900	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS01925	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS01940	COG2030	dehydratase
SPRI_RS01945	COG0183	Belongs to the thiolase family
SPRI_RS01960	COG1309	transcriptional regulator
SPRI_RS01965	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS01970	COG1024	Enoyl-CoA hydratase
SPRI_RS01975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_RS02000	COG0804	urea catabolic process
SPRI_RS02030	COG2226	methyltransferase
SPRI_RS02050	COG3693	PFAM glycoside hydrolase, family 10
SPRI_RS02065	COG0596	Alpha beta hydrolase
SPRI_RS02095	COG1309	transcriptional regulator
SPRI_RS02135	COG0765	amino acid transport
SPRI_RS02140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_RS02150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_RS02150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_RS02160	COG2814	Major facilitator Superfamily
SPRI_RS02190	COG0583	DNA-binding transcription factor activity
SPRI_RS02195	COG0156	8-amino-7-oxononanoate synthase activity
SPRI_RS02200	COG1063	alcohol dehydrogenase
SPRI_RS02210	COG2018	Roadblock/LC7 domain
SPRI_RS02265	COG3239	Fatty acid desaturase
SPRI_RS02270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_RS02300	COG1124	(ABC) transporter
SPRI_RS02305	COG0444	Belongs to the ABC transporter superfamily
SPRI_RS02310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS02315	COG0601	transmembrane transport
SPRI_RS02325	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS02330	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS02360	COG3458	cephalosporin-C deacetylase activity
SPRI_RS02385	COG4989	oxidoreductase activity
SPRI_RS02415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPRI_RS02420	COG1609	Transcriptional regulator
SPRI_RS02440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS02455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPRI_RS02460	COG1349	DNA-binding transcription factor activity
SPRI_RS02470	COG0673	inositol 2-dehydrogenase activity
SPRI_RS02490	COG1309	transcriptional regulator
SPRI_RS02510	COG3540	Alkaline phosphatase
SPRI_RS02515	COG0300	oxidoreductase activity
SPRI_RS02525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPRI_RS02545	COG2208	phosphoserine phosphatase activity
SPRI_RS02565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_RS02580	COG1090	epimerase
SPRI_RS02590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPRI_RS02610	COG0142	geranyltranstransferase activity
SPRI_RS02620	COG1874	Beta-galactosidase
SPRI_RS02620	COG0366	Alpha amylase catalytic
SPRI_RS02630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_RS02635	COG1132	(ABC) transporter
SPRI_RS02645	COG1175	transmembrane transport
SPRI_RS02655	COG3250	beta-galactosidase activity
SPRI_RS02660	COG1609	Transcriptional regulator
SPRI_RS02680	COG1733	regulation of RNA biosynthetic process
SPRI_RS02690	COG0181	hydroxymethylbilane synthase activity
SPRI_RS02695	COG1032	radical SAM domain protein
SPRI_RS02705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_RS02710	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPRI_RS02730	COG1609	Transcriptional regulator
SPRI_RS02735	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPRI_RS02745	COG1129	ABC transporter
SPRI_RS02750	COG1879	ABC-type sugar transport system periplasmic component
SPRI_RS02765	COG1609	Transcriptional regulator
SPRI_RS02825	COG1940	carbohydrate kinase activity
SPRI_RS02835	COG1175	transmembrane transport
SPRI_RS02840	COG0395	ABC-type sugar transport system, permease component
SPRI_RS02845	COG2723	6-phospho-beta-galactosidase activity
SPRI_RS02850	COG0366	Alpha amylase catalytic
SPRI_RS02855	COG0395	ABC-type sugar transport system, permease component
SPRI_RS02860	COG1175	transmembrane transport
SPRI_RS02865	COG1653	transport
SPRI_RS02885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SPRI_RS02895	COG2255	four-way junction helicase activity
SPRI_RS02950	COG0494	nUDIX hydrolase
SPRI_RS02970	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPRI_RS02975	COG0328	RNA-DNA hybrid ribonuclease activity
SPRI_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS03030	COG2072	flavoprotein involved in K transport
SPRI_RS03065	COG1733	regulation of RNA biosynthetic process
SPRI_RS03120	COG0583	DNA-binding transcription factor activity
SPRI_RS03165	COG0598	Magnesium transport protein CorA
SPRI_RS03170	COG3226	Transcriptional regulator
SPRI_RS03175	COG0110	maltose O-acetyltransferase activity
SPRI_RS03190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPRI_RS03255	COG0523	cobalamin synthesis protein
SPRI_RS03275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS03280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPRI_RS03285	COG0640	Transcriptional regulator
SPRI_RS03290	COG0346	lactoylglutathione lyase activity
SPRI_RS03350	COG0455	bacterial-type flagellum organization
SPRI_RS03370	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_RS03375	COG1595	DNA-templated transcription, initiation
SPRI_RS03390	COG0148	phosphopyruvate hydratase activity
SPRI_RS03415	COG0235	Class ii aldolase
SPRI_RS03420	COG3395	kinase activity
SPRI_RS03425	COG0473	3-isopropylmalate dehydrogenase activity
SPRI_RS03430	COG1082	Xylose isomerase domain protein TIM barrel
SPRI_RS03445	COG2851	Citrate transporter
SPRI_RS03505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPRI_RS03525	COG3572	ergothioneine biosynthetic process
SPRI_RS03530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPRI_RS03535	COG0121	glutamine amidotransferase
SPRI_RS03540	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SPRI_RS03555	COG2182	Extracellular solute-binding protein
SPRI_RS03565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_RS03570	COG0395	ABC-type sugar transport system, permease component
SPRI_RS03575	COG1175	transmembrane transport
SPRI_RS03580	COG2182	Extracellular solute-binding protein
SPRI_RS03585	COG2188	Transcriptional regulator
SPRI_RS03595	COG4585	Histidine kinase
SPRI_RS03600	COG2197	response regulator
SPRI_RS03610	COG2409	Drug exporters of the RND superfamily
SPRI_RS03615	COG2188	Transcriptional regulator
SPRI_RS03620	COG3360	Dodecin
SPRI_RS03630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS03645	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPRI_RS03650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPRI_RS03655	COG1053	succinate dehydrogenase
SPRI_RS03665	COG0583	DNA-binding transcription factor activity
SPRI_RS03685	COG2267	carboxylic ester hydrolase activity
SPRI_RS03740	COG3275	phosphorelay sensor kinase activity
SPRI_RS03745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_RS03770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_RS03775	COG3618	amidohydrolase
SPRI_RS03845	COG1063	alcohol dehydrogenase
SPRI_RS03850	COG0395	ABC-type sugar transport system, permease component
SPRI_RS03855	COG1175	transmembrane transport
SPRI_RS03870	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPRI_RS03885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SPRI_RS03890	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS03900	COG3246	L-lysine catabolic process to acetate
SPRI_RS03910	COG2175	clavaminate synthase activity
SPRI_RS03915	COG2271	Major facilitator Superfamily
SPRI_RS03925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_RS03935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPRI_RS03935	COG1796	DNA polymerase
SPRI_RS03955	COG0456	acetyltransferase
SPRI_RS03975	COG3655	Transcriptional regulator
SPRI_RS03990	COG1846	Transcriptional regulator
SPRI_RS03995	COG1733	regulation of RNA biosynthetic process
SPRI_RS04035	COG0284	orotidine-5'-phosphate decarboxylase activity
SPRI_RS04070	COG1595	DNA-templated transcription, initiation
SPRI_RS04090	COG3629	intracellular signal transduction
SPRI_RS04090	COG3903	Transcriptional regulator
SPRI_RS04115	COG3708	Transcriptional regulator
SPRI_RS04115	COG2207	Transcriptional regulator
SPRI_RS04130	COG1881	PFAM PEBP family protein
SPRI_RS04135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPRI_RS04150	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS04160	COG1733	regulation of RNA biosynthetic process
SPRI_RS04195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_RS04210	COG1802	Transcriptional regulator
SPRI_RS04225	COG1175	transmembrane transport
SPRI_RS04230	COG0395	ABC-type sugar transport system, permease component
SPRI_RS04250	COG1653	transport
SPRI_RS04255	COG2755	lipolytic protein G-D-S-L family
SPRI_RS04260	COG3866	Pectate lyase
SPRI_RS04265	COG4677	pectinesterase activity
SPRI_RS04280	COG1595	DNA-templated transcription, initiation
SPRI_RS04290	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_RS04295	COG4733	cellulase activity
SPRI_RS04295	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_RS04385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPRI_RS04385	COG0515	serine threonine protein kinase
SPRI_RS04395	COG1609	Transcriptional regulator
SPRI_RS04400	COG3896	Chloramphenicol phosphotransferase-like protein
SPRI_RS04410	COG0395	ABC-type sugar transport system, permease component
SPRI_RS04415	COG1175	transmembrane transport
SPRI_RS04430	COG1070	Carbohydrate kinase
SPRI_RS04510	COG1120	ATPase activity
SPRI_RS04515	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS04530	COG1132	(ABC) transporter
SPRI_RS04545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPRI_RS04550	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SPRI_RS04580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPRI_RS04590	COG3959	Transketolase, thiamine diphosphate binding domain
SPRI_RS04595	COG3958	Transketolase
SPRI_RS04625	COG3507	Belongs to the glycosyl hydrolase 43 family
SPRI_RS04635	COG1116	anion transmembrane transporter activity
SPRI_RS04645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPRI_RS04685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_RS04720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPRI_RS04730	COG2755	lipolytic protein G-D-S-L family
SPRI_RS04745	COG2365	Tyrosine phosphatase family
SPRI_RS04770	COG1657	PFAM Prenyltransferase squalene oxidase
SPRI_RS04780	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SPRI_RS04790	COG1562	ergosterol biosynthetic process
SPRI_RS04795	COG1134	teichoic acid transport
SPRI_RS04795	COG1388	LysM domain
SPRI_RS04815	COG0371	Dehydrogenase
SPRI_RS04845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPRI_RS04860	COG1024	Enoyl-CoA hydratase
SPRI_RS04870	COG4977	sequence-specific DNA binding
SPRI_RS04890	COG2183	response to ionizing radiation
SPRI_RS04915	COG4608	Belongs to the ABC transporter superfamily
SPRI_RS04920	COG0444	Belongs to the ABC transporter superfamily
SPRI_RS04925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS04950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPRI_RS04980	COG0395	ABC-type sugar transport system, permease component
SPRI_RS05000	COG3568	Endonuclease Exonuclease Phosphatase
SPRI_RS05030	COG0789	Transcriptional regulator
SPRI_RS05040	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_RS05040	COG1024	Enoyl-CoA hydratase
SPRI_RS05045	COG0183	Belongs to the thiolase family
SPRI_RS05050	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS05055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_RS05060	COG3268	Saccharopine dehydrogenase
SPRI_RS05070	COG1515	deoxyribonuclease V activity
SPRI_RS05095	COG0488	(ABC) transporter
SPRI_RS05105	COG3415	Transposase
SPRI_RS05105	COG2801	Transposase and inactivated derivatives
SPRI_RS05150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS05185	COG3285	dna ligase
SPRI_RS05185	COG1793	dna ligase
SPRI_RS05190	COG1793	dna ligase
SPRI_RS05250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPRI_RS05285	COG3012	SEC-C Motif Domain Protein
SPRI_RS05295	COG1486	melibiose metabolic process
SPRI_RS05325	COG0431	NADPH-dependent FMN reductase
SPRI_RS05340	COG0477	Major facilitator Superfamily
SPRI_RS05345	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SPRI_RS05375	COG2318	DinB family
SPRI_RS05385	COG1396	sequence-specific DNA binding
SPRI_RS05460	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_RS05465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SPRI_RS05470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPRI_RS05475	COG0583	DNA-binding transcription factor activity
SPRI_RS05490	COG0477	Major facilitator Superfamily
SPRI_RS05520	COG2855	membrane
SPRI_RS05530	COG0583	DNA-binding transcription factor activity
SPRI_RS05545	COG0475	glutathione-regulated potassium exporter activity
SPRI_RS05565	COG0789	Transcriptional regulator
SPRI_RS05575	COG0789	Transcriptional regulator
SPRI_RS05595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPRI_RS05595	COG0515	serine threonine protein kinase
SPRI_RS05630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPRI_RS05665	COG1132	(ABC) transporter
SPRI_RS05705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPRI_RS05785	COG3401	FG-GAP repeat protein
SPRI_RS05820	COG1595	DNA-templated transcription, initiation
SPRI_RS05825	COG1802	Transcriptional regulator
SPRI_RS05830	COG3938	Belongs to the proline racemase family
SPRI_RS05850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_RS05900	COG4977	sequence-specific DNA binding
SPRI_RS05920	COG1869	D-ribose catabolic process
SPRI_RS05925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS05930	COG1879	ABC-type sugar transport system periplasmic component
SPRI_RS05935	COG1129	ABC transporter
SPRI_RS05975	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS05985	COG0045	succinate-CoA ligase (ADP-forming) activity
SPRI_RS05995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_RS06005	COG2223	nitrite transmembrane transporter activity
SPRI_RS06015	COG0789	Transcriptional regulator
SPRI_RS06055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SPRI_RS06075	COG0673	inositol 2-dehydrogenase activity
SPRI_RS06085	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPRI_RS06090	COG1129	ABC transporter
SPRI_RS06095	COG1940	carbohydrate kinase activity
SPRI_RS06120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS06125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SPRI_RS06130	COG3383	formate dehydrogenase (NAD+) activity
SPRI_RS06145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SPRI_RS06155	COG0477	Major facilitator Superfamily
SPRI_RS06210	COG0656	L-ascorbic acid biosynthetic process
SPRI_RS06235	COG2154	pterin-4-alpha-carbinolamine dehydratase
SPRI_RS06245	COG1793	dna ligase
SPRI_RS06285	COG0531	amino acid
SPRI_RS06295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPRI_RS06320	COG2226	methyltransferase
SPRI_RS06345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_RS06350	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPRI_RS06355	COG1506	peptidase
SPRI_RS06355	COG0823	Involved in the tonB-independent uptake of proteins
SPRI_RS06355	COG4946	Tricorn protease homolog
SPRI_RS06360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_RS06365	COG2362	D-Aminopeptidase
SPRI_RS06370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_RS06375	COG1834	amidinotransferase
SPRI_RS06415	COG2208	phosphoserine phosphatase activity
SPRI_RS06415	COG2172	sigma factor antagonist activity
SPRI_RS06415	COG1366	Belongs to the anti-sigma-factor antagonist family
SPRI_RS06420	COG2814	Major facilitator Superfamily
SPRI_RS06445	COG0659	secondary active sulfate transmembrane transporter activity
SPRI_RS06455	COG0745	RESPONSE REGULATOR receiver
SPRI_RS06460	COG2205	protein histidine kinase activity
SPRI_RS06465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_RS06475	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_RS06485	COG0604	alcohol dehydrogenase
SPRI_RS06490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS06490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS06505	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS06510	COG0688	phosphatidylethanolamine metabolic process
SPRI_RS06535	COG0559	Belongs to the binding-protein-dependent transport system permease family
SPRI_RS06550	COG1929	Belongs to the glycerate kinase type-1 family
SPRI_RS06555	COG0494	nUDIX hydrolase
SPRI_RS06565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPRI_RS06570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPRI_RS06600	COG0483	inositol monophosphate 1-phosphatase activity
SPRI_RS06605	COG0405	Gamma-glutamyltransferase
SPRI_RS06615	COG2986	histidine ammonia-lyase
SPRI_RS06625	COG1846	Transcriptional regulator
SPRI_RS06635	COG2197	response regulator
SPRI_RS06640	COG4585	Histidine kinase
SPRI_RS06650	COG2226	methyltransferase
SPRI_RS06665	COG0300	oxidoreductase activity
SPRI_RS06675	COG1953	Uracil, thiamine, allantoin
SPRI_RS06685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPRI_RS06690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_RS06725	COG0405	Gamma-glutamyltransferase
SPRI_RS06740	COG1126	abc transporter atp-binding protein
SPRI_RS06760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_RS06765	COG1132	(ABC) transporter
SPRI_RS06860	COG0739	heme binding
SPRI_RS06905	COG1940	carbohydrate kinase activity
SPRI_RS06925	COG1879	ABC-type sugar transport system periplasmic component
SPRI_RS06930	COG2188	Transcriptional regulator
SPRI_RS06935	COG0673	inositol 2-dehydrogenase activity
SPRI_RS06955	COG2197	response regulator
SPRI_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS06990	COG4266	Belongs to the allantoicase family
SPRI_RS06995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPRI_RS07000	COG1414	Transcriptional regulator
SPRI_RS07005	COG3537	Alpha-1,2-mannosidase
SPRI_RS07010	COG1136	(ABC) transporter
SPRI_RS07025	COG2197	response regulator
SPRI_RS07045	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SPRI_RS07060	COG2267	carboxylic ester hydrolase activity
SPRI_RS07070	COG1733	regulation of RNA biosynthetic process
SPRI_RS07080	COG2226	methyltransferase
SPRI_RS07085	COG0154	amidase activity
SPRI_RS07095	COG1733	regulation of RNA biosynthetic process
SPRI_RS07180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS07215	COG4977	sequence-specific DNA binding
SPRI_RS07225	COG0477	Major facilitator Superfamily
SPRI_RS07235	COG0714	Associated with various cellular activities
SPRI_RS07250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPRI_RS07255	COG3119	arylsulfatase activity
SPRI_RS07295	COG0628	permease
SPRI_RS07320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_RS07320	COG3291	Pkd domain containing protein
SPRI_RS07355	COG2367	Beta-lactamase
SPRI_RS07360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_RS07385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_RS07385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_RS07400	COG2208	phosphoserine phosphatase activity
SPRI_RS07430	COG2318	DinB family
SPRI_RS07440	COG2340	Cysteine-rich secretory protein family
SPRI_RS07445	COG0515	serine threonine protein kinase
SPRI_RS07445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPRI_RS07450	COG2205	protein histidine kinase activity
SPRI_RS07455	COG0745	RESPONSE REGULATOR receiver
SPRI_RS07470	COG3866	Pectate lyase
SPRI_RS07480	COG2272	Belongs to the type-B carboxylesterase lipase family
SPRI_RS07520	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPRI_RS07550	COG2356	endonuclease I
SPRI_RS07555	COG1063	alcohol dehydrogenase
SPRI_RS07565	COG2233	PERMEase
SPRI_RS07575	COG2233	PERMEase
SPRI_RS07585	COG2351	hydroxyisourate hydrolase activity
SPRI_RS07625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPRI_RS07675	COG3622	Belongs to the hyi family
SPRI_RS07680	COG2084	Dehydrogenase
SPRI_RS07685	COG0753	catalase activity
SPRI_RS07695	COG3960	tartronate-semialdehyde synthase activity
SPRI_RS07710	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS07715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_RS07720	COG2197	response regulator
SPRI_RS07730	COG2326	polyphosphate kinase activity
SPRI_RS07765	COG1595	DNA-templated transcription, initiation
SPRI_RS07790	COG2252	PERMEase
SPRI_RS07795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPRI_RS07815	COG1132	(ABC) transporter
SPRI_RS07850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS07855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS07890	COG1802	Transcriptional regulator
SPRI_RS07910	COG0028	Belongs to the TPP enzyme family
SPRI_RS07920	COG1404	Belongs to the peptidase S8 family
SPRI_RS07935	COG1162	GTPase activity
SPRI_RS07945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPRI_RS07945	COG1796	DNA polymerase
SPRI_RS07960	COG2304	oxidoreductase activity
SPRI_RS08020	COG0475	glutathione-regulated potassium exporter activity
SPRI_RS08040	COG1063	alcohol dehydrogenase
SPRI_RS08045	COG2130	NADP-dependent
SPRI_RS08050	COG1733	regulation of RNA biosynthetic process
SPRI_RS08055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPRI_RS08065	COG5002	protein histidine kinase activity
SPRI_RS08070	COG0745	RESPONSE REGULATOR receiver
SPRI_RS08090	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS08105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPRI_RS08110	COG0175	sulfate reduction
SPRI_RS08115	COG0529	Catalyzes the synthesis of activated sulfate
SPRI_RS08140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SPRI_RS08145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPRI_RS08155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SPRI_RS08160	COG2132	Multicopper oxidase
SPRI_RS08175	COG2409	Drug exporters of the RND superfamily
SPRI_RS08200	COG1175	transmembrane transport
SPRI_RS08235	COG0583	DNA-binding transcription factor activity
SPRI_RS08240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPRI_RS08280	COG0346	lactoylglutathione lyase activity
SPRI_RS08285	COG2706	6-phosphogluconolactonase activity
SPRI_RS08350	COG3469	chitinase activity
SPRI_RS08355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SPRI_RS08370	COG2318	DinB family
SPRI_RS08390	COG2197	response regulator
SPRI_RS08395	COG4585	Histidine kinase
SPRI_RS08460	COG1073	alpha beta
SPRI_RS08465	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
SPRI_RS08465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPRI_RS08500	COG1131	(ABC) transporter
SPRI_RS08505	COG4585	Histidine kinase
SPRI_RS08510	COG2197	response regulator
SPRI_RS08520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPRI_RS08525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPRI_RS08560	COG1764	response to oxidative stress
SPRI_RS08565	COG1846	Transcriptional regulator
SPRI_RS08570	COG0395	ABC-type sugar transport system, permease component
SPRI_RS08575	COG1175	transmembrane transport
SPRI_RS08585	COG0366	Alpha amylase catalytic
SPRI_RS08590	COG1653	transport
SPRI_RS08600	COG1136	(ABC) transporter
SPRI_RS08645	COG4152	abc transporter atp-binding protein
SPRI_RS08680	COG4977	sequence-specific DNA binding
SPRI_RS08695	COG3220	belongs to the UPF0276 family
SPRI_RS08705	COG0596	Alpha beta hydrolase
SPRI_RS08710	COG3253	May function as heme-dependent peroxidase
SPRI_RS08715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SPRI_RS08725	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPRI_RS08735	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPRI_RS08755	COG0583	DNA-binding transcription factor activity
SPRI_RS08765	COG0183	Belongs to the thiolase family
SPRI_RS08780	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS08790	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS08815	COG0531	amino acid
SPRI_RS08820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPRI_RS08825	COG4214	carbohydrate transport
SPRI_RS08835	COG4213	ABC transporter substrate-binding protein
SPRI_RS08840	COG1940	carbohydrate kinase activity
SPRI_RS08855	COG3226	Transcriptional regulator
SPRI_RS08860	COG2267	carboxylic ester hydrolase activity
SPRI_RS08865	COG0395	ABC-type sugar transport system, permease component
SPRI_RS08870	COG1175	transmembrane transport
SPRI_RS08875	COG1653	transport
SPRI_RS08895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SPRI_RS08915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPRI_RS08930	COG1959	2 iron, 2 sulfur cluster binding
SPRI_RS08945	COG2267	carboxylic ester hydrolase activity
SPRI_RS08990	COG1024	Enoyl-CoA hydratase
SPRI_RS09000	COG0531	amino acid
SPRI_RS09005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPRI_RS09065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPRI_RS09075	COG2040	homocysteine
SPRI_RS09100	COG1799	cell septum assembly
SPRI_RS09120	COG0366	Alpha amylase catalytic
SPRI_RS09130	COG1175	transmembrane transport
SPRI_RS09135	COG2182	Extracellular solute-binding protein
SPRI_RS09140	COG1609	Transcriptional regulator
SPRI_RS09150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS09155	COG0395	ABC-type sugar transport system, permease component
SPRI_RS09160	COG1175	transmembrane transport
SPRI_RS09180	COG3250	beta-galactosidase activity
SPRI_RS09180	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_RS09185	COG2723	6-phospho-beta-galactosidase activity
SPRI_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS09195	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS09205	COG0859	PFAM glycosyl transferase family 9
SPRI_RS09210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPRI_RS09210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SPRI_RS09215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SPRI_RS09220	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS09230	COG0859	PFAM glycosyl transferase family 9
SPRI_RS09235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPRI_RS09245	COG2192	nodulation
SPRI_RS09250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPRI_RS09260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPRI_RS09285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS09290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS09305	COG2867	negative regulation of translational initiation
SPRI_RS09305	COG2226	methyltransferase
SPRI_RS09415	COG2132	Multicopper oxidase
SPRI_RS09435	COG2197	response regulator
SPRI_RS09480	COG1196	nuclear chromosome segregation
SPRI_RS09480	COG0741	lytic transglycosylase activity
SPRI_RS09480	COG0739	heme binding
SPRI_RS09510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPRI_RS09520	COG0477	Major facilitator Superfamily
SPRI_RS09525	COG0456	acetyltransferase
SPRI_RS09540	COG1984	allophanate hydrolase subunit 2
SPRI_RS09545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPRI_RS09550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SPRI_RS09560	COG0640	Transcriptional regulator
SPRI_RS09575	COG2205	protein histidine kinase activity
SPRI_RS09580	COG0745	RESPONSE REGULATOR receiver
SPRI_RS09605	COG0513	Belongs to the DEAD box helicase family
SPRI_RS09610	COG1278	Cold shock
SPRI_RS09615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SPRI_RS09645	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_RS09655	COG0702	epimerase
SPRI_RS09695	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SPRI_RS09750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPRI_RS09755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPRI_RS09775	COG0367	asparagine synthase
SPRI_RS09800	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS09810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPRI_RS09825	COG4310	Domain of unknown function (DUF2172)
SPRI_RS09835	COG1215	transferase activity, transferring glycosyl groups
SPRI_RS09850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPRI_RS09885	COG0590	tRNA wobble adenosine to inosine editing
SPRI_RS09895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPRI_RS09900	COG0531	amino acid
SPRI_RS09905	COG0569	domain protein
SPRI_RS09935	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPRI_RS09935	COG1136	(ABC) transporter
SPRI_RS09945	COG0756	dUTP diphosphatase activity
SPRI_RS09970	COG2205	protein histidine kinase activity
SPRI_RS09975	COG0745	RESPONSE REGULATOR receiver
SPRI_RS09985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPRI_RS10045	COG1435	thymidine kinase activity
SPRI_RS10065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPRI_RS10070	COG1802	Transcriptional regulator
SPRI_RS10085	COG0612	Peptidase, M16
SPRI_RS10090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPRI_RS10110	COG3290	protein histidine kinase activity
SPRI_RS10120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_RS10130	COG2197	response regulator
SPRI_RS10135	COG4585	Histidine kinase
SPRI_RS10140	COG0187	DNA topoisomerase II activity
SPRI_RS10155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPRI_RS10160	COG1802	Transcriptional regulator
SPRI_RS10195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPRI_RS10215	COG0588	phosphoglycerate mutase activity
SPRI_RS10220	COG0488	(ABC) transporter
SPRI_RS10245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPRI_RS10250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPRI_RS10255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPRI_RS10295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPRI_RS10305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPRI_RS10310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SPRI_RS10320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPRI_RS10340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPRI_RS10350	COG2205	protein histidine kinase activity
SPRI_RS10355	COG0745	RESPONSE REGULATOR receiver
SPRI_RS10360	COG1126	abc transporter atp-binding protein
SPRI_RS10365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_RS10370	COG0765	amino acid transport
SPRI_RS10375	COG0765	amino acid transport
SPRI_RS10380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_RS10420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPRI_RS10455	COG1201	RNA secondary structure unwinding
SPRI_RS10460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS10475	COG1396	sequence-specific DNA binding
SPRI_RS10480	COG1058	Belongs to the CinA family
SPRI_RS10480	COG1546	Belongs to the CinA family
SPRI_RS10490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPRI_RS10500	COG1674	ftsk spoiiie
SPRI_RS10510	COG0784	Response regulator, receiver
SPRI_RS10510	COG2205	protein histidine kinase activity
SPRI_RS10515	COG2770	Histidine kinase
SPRI_RS10515	COG2208	phosphoserine phosphatase activity
SPRI_RS10545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPRI_RS10550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_RS10555	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SPRI_RS10575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPRI_RS10580	COG0612	Peptidase, M16
SPRI_RS10585	COG1185	polyribonucleotide nucleotidyltransferase activity
SPRI_RS10590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SPRI_RS10600	COG1674	ftsk spoiiie
SPRI_RS10620	COG1404	Belongs to the peptidase S8 family
SPRI_RS10640	COG0455	bacterial-type flagellum organization
SPRI_RS10650	COG0601	transmembrane transport
SPRI_RS10655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS10660	COG0444	Belongs to the ABC transporter superfamily
SPRI_RS10665	COG4608	Belongs to the ABC transporter superfamily
SPRI_RS10670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPRI_RS10685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPRI_RS10690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPRI_RS10700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPRI_RS10720	COG0779	Required for maturation of 30S ribosomal subunits
SPRI_RS10740	COG0442	prolyl-tRNA aminoacylation
SPRI_RS10755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPRI_RS10760	COG0750	zinc metalloprotease
SPRI_RS10765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPRI_RS10790	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS10795	COG0697	spore germination
SPRI_RS10800	COG2508	Transcriptional regulator
SPRI_RS10830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_RS10835	COG1177	transmembrane transport
SPRI_RS10840	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPRI_RS10845	COG3842	ATPase activity
SPRI_RS10850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SPRI_RS10870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_RS10885	COG4585	Histidine kinase
SPRI_RS10890	COG2197	response regulator
SPRI_RS10895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_RS10900	COG0300	oxidoreductase activity
SPRI_RS10910	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS10920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPRI_RS10925	COG1136	(ABC) transporter
SPRI_RS10940	COG3842	ATPase activity
SPRI_RS10955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPRI_RS10970	COG0575	Belongs to the CDS family
SPRI_RS10975	COG0233	cytoplasmic translational termination
SPRI_RS10980	COG0528	UMP kinase activity
SPRI_RS10985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPRI_RS10990	COG0052	Belongs to the universal ribosomal protein uS2 family
SPRI_RS11000	COG1191	sigma factor activity
SPRI_RS11015	COG0792	nuclease activity
SPRI_RS11030	COG0681	Belongs to the peptidase S26 family
SPRI_RS11035	COG0681	Belongs to the peptidase S26 family
SPRI_RS11045	COG0681	Belongs to the peptidase S26 family
SPRI_RS11050	COG0335	large ribosomal subunit rRNA binding
SPRI_RS11055	COG0336	Belongs to the RNA methyltransferase TrmD family
SPRI_RS11060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPRI_RS11065	COG1837	Belongs to the UPF0109 family
SPRI_RS11070	COG0228	four-way junction DNA binding
SPRI_RS11080	COG0442	prolyl-tRNA aminoacylation
SPRI_RS11095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SPRI_RS11125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SPRI_RS11135	COG0477	Major facilitator Superfamily
SPRI_RS11140	COG1196	nuclear chromosome segregation
SPRI_RS11150	COG1254	Belongs to the acylphosphatase family
SPRI_RS11155	COG2340	Cysteine-rich secretory protein family
SPRI_RS11170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_RS11175	COG0571	ribonuclease III activity
SPRI_RS11180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SPRI_RS11195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPRI_RS11200	COG0742	ribosomal rna small subunit methyltransferase
SPRI_RS11210	COG0326	Molecular chaperone. Has ATPase activity
SPRI_RS11220	COG1461	Dihydroxyacetone kinase
SPRI_RS11225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPRI_RS11230	COG0351	phosphomethylpyrimidine kinase
SPRI_RS11250	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPRI_RS11255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPRI_RS11265	COG1920	GTP binding
SPRI_RS11275	COG0776	regulation of translation
SPRI_RS11285	COG0066	3-isopropylmalate dehydratase activity
SPRI_RS11290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPRI_RS11295	COG1414	Transcriptional regulator
SPRI_RS11340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPRI_RS11345	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPRI_RS11350	COG5002	protein histidine kinase activity
SPRI_RS11355	COG2018	Roadblock/LC7 domain
SPRI_RS11375	COG2018	Roadblock/LC7 domain
SPRI_RS11405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_RS11410	COG0366	Alpha amylase catalytic
SPRI_RS11410	COG1470	cell adhesion involved in biofilm formation
SPRI_RS11425	COG2353	YceI-like domain
SPRI_RS11440	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_RS11445	COG1609	Transcriptional regulator
SPRI_RS11455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPRI_RS11465	COG2957	Belongs to the agmatine deiminase family
SPRI_RS11470	COG0804	urea catabolic process
SPRI_RS11475	COG0832	Belongs to the urease beta subunit family
SPRI_RS11475	COG0831	urea catabolic process
SPRI_RS11485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPRI_RS11490	COG0473	3-isopropylmalate dehydrogenase activity
SPRI_RS11495	COG1695	Transcriptional regulator
SPRI_RS11515	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS11520	COG0506	proline dehydrogenase activity
SPRI_RS11535	COG0477	Major facilitator Superfamily
SPRI_RS11550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPRI_RS11555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPRI_RS11560	COG0440	acetolactate synthase activity
SPRI_RS11580	COG0667	Aldo Keto reductase
SPRI_RS11585	COG2133	pyrroloquinoline quinone binding
SPRI_RS11595	COG2197	response regulator
SPRI_RS11615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPRI_RS11620	COG2409	Drug exporters of the RND superfamily
SPRI_RS11640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPRI_RS11650	COG0154	amidase activity
SPRI_RS11655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPRI_RS11665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPRI_RS11675	COG4221	oxidoreductase activity
SPRI_RS11695	COG0482	sulfurtransferase activity
SPRI_RS11730	COG2860	membrane
SPRI_RS11735	COG4608	Belongs to the ABC transporter superfamily
SPRI_RS11740	COG0444	Belongs to the ABC transporter superfamily
SPRI_RS11745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS11750	COG0601	transmembrane transport
SPRI_RS11755	COG0747	negative chemotaxis
SPRI_RS11775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPRI_RS11780	COG0509	glycine decarboxylation via glycine cleavage system
SPRI_RS11785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPRI_RS11790	COG1760	l-serine dehydratase
SPRI_RS11815	COG2197	response regulator
SPRI_RS11820	COG1132	(ABC) transporter
SPRI_RS11825	COG1132	(ABC) transporter
SPRI_RS11835	COG0515	serine threonine protein kinase
SPRI_RS11840	COG1024	Enoyl-CoA hydratase
SPRI_RS11845	COG1376	ErfK ybiS ycfS ynhG family protein
SPRI_RS11860	COG2197	response regulator
SPRI_RS11865	COG4585	Histidine kinase
SPRI_RS11875	COG1131	(ABC) transporter
SPRI_RS11885	COG1132	(ABC) transporter
SPRI_RS11905	COG4585	Histidine kinase
SPRI_RS11910	COG2252	PERMEase
SPRI_RS11965	COG0058	SHG alpha-glucan phosphorylase activity
SPRI_RS11970	COG0366	Alpha amylase catalytic
SPRI_RS11985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPRI_RS11990	COG3973	AAA domain
SPRI_RS12005	COG0745	RESPONSE REGULATOR receiver
SPRI_RS12020	COG1595	DNA-templated transcription, initiation
SPRI_RS12025	COG3118	belongs to the thioredoxin family
SPRI_RS12035	COG1301	dicarboxylic acid transport
SPRI_RS12040	COG3290	protein histidine kinase activity
SPRI_RS12045	COG4565	transcriptional regulatory protein
SPRI_RS12055	COG1175	transmembrane transport
SPRI_RS12060	COG0395	ABC-type sugar transport system, permease component
SPRI_RS12085	COG0205	6-phosphofructokinase activity
SPRI_RS12090	COG0857	belongs to the CobB CobQ family
SPRI_RS12090	COG0280	phosphate acetyltransferase
SPRI_RS12095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPRI_RS12110	COG2188	Transcriptional regulator
SPRI_RS12145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS12145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS12215	COG2205	protein histidine kinase activity
SPRI_RS12220	COG0745	RESPONSE REGULATOR receiver
SPRI_RS12235	COG0183	Belongs to the thiolase family
SPRI_RS12290	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SPRI_RS12295	COG1136	(ABC) transporter
SPRI_RS12305	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_RS12320	COG4585	Histidine kinase
SPRI_RS12325	COG2197	response regulator
SPRI_RS12340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPRI_RS12345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SPRI_RS12350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPRI_RS12355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SPRI_RS12360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPRI_RS12365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SPRI_RS12370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPRI_RS12390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPRI_RS12395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPRI_RS12405	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_RS12410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPRI_RS12415	COG0254	rRNA binding
SPRI_RS12420	COG1316	TRANSCRIPTIONal
SPRI_RS12430	COG0083	homoserine kinase activity
SPRI_RS12435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPRI_RS12440	COG0460	homoserine dehydrogenase
SPRI_RS12445	COG0019	diaminopimelate decarboxylase activity
SPRI_RS12450	COG0018	arginyl-trna synthetase
SPRI_RS12575	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS12605	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SPRI_RS12610	COG3285	dna ligase
SPRI_RS12610	COG1793	dna ligase
SPRI_RS12640	COG0768	penicillin binding
SPRI_RS12675	COG0791	NLP P60 protein
SPRI_RS12675	COG3883	PFAM NLP P60 protein
SPRI_RS12720	COG1357	PFAM Pentapeptide repeats (8 copies)
SPRI_RS12725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SPRI_RS12745	COG0745	RESPONSE REGULATOR receiver
SPRI_RS12750	COG2205	protein histidine kinase activity
SPRI_RS12755	COG0567	Dehydrogenase, E1 component
SPRI_RS12755	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPRI_RS12805	COG0604	alcohol dehydrogenase
SPRI_RS12810	COG3540	Alkaline phosphatase
SPRI_RS12830	COG0765	amino acid transport
SPRI_RS12835	COG1126	abc transporter atp-binding protein
SPRI_RS12840	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_RS12875	COG5640	endopeptidase activity
SPRI_RS12890	COG0142	geranyltranstransferase activity
SPRI_RS12895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_RS12900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SPRI_RS12930	COG1597	lipid kinase activity
SPRI_RS12945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SPRI_RS12950	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_RS12955	COG0395	ABC-type sugar transport system, permease component
SPRI_RS12960	COG1175	transmembrane transport
SPRI_RS12970	COG2188	Transcriptional regulator
SPRI_RS13005	COG0242	peptide deformylase activity
SPRI_RS13020	COG2199	diguanylate cyclase activity
SPRI_RS13020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SPRI_RS13025	COG5662	AntiSigma factor
SPRI_RS13030	COG1595	DNA-templated transcription, initiation
SPRI_RS13040	COG2135	peptidase activity
SPRI_RS13050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPRI_RS13055	COG1162	GTPase activity
SPRI_RS13060	COG2076	Multidrug Resistance protein
SPRI_RS13070	COG0483	inositol monophosphate 1-phosphatase activity
SPRI_RS13080	COG0753	catalase activity
SPRI_RS13105	COG1615	UPF0182 protein
SPRI_RS13115	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPRI_RS13165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SPRI_RS13210	COG0210	DNA helicase
SPRI_RS13305	COG0513	Belongs to the DEAD box helicase family
SPRI_RS13315	COG1432	Conserved Protein
SPRI_RS13320	COG2095	MarC family integral membrane protein
SPRI_RS13340	COG0598	Magnesium transport protein CorA
SPRI_RS13375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPRI_RS13380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_RS13390	COG1595	DNA-templated transcription, initiation
SPRI_RS13400	COG1024	Enoyl-CoA hydratase
SPRI_RS13405	COG2818	Glycosylase
SPRI_RS13415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPRI_RS13420	COG1611	Belongs to the LOG family
SPRI_RS13425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_RS13465	COG3209	COG3209 Rhs family protein
SPRI_RS13490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SPRI_RS13510	COG4608	Belongs to the ABC transporter superfamily
SPRI_RS13520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS13525	COG0601	transmembrane transport
SPRI_RS13545	COG4608	Belongs to the ABC transporter superfamily
SPRI_RS13550	COG0444	Belongs to the ABC transporter superfamily
SPRI_RS13555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS13560	COG0601	transmembrane transport
SPRI_RS13565	COG4166	transmembrane transport
SPRI_RS13570	COG1217	gtp-binding protein TYPA
SPRI_RS13610	COG1842	Phage shock protein A
SPRI_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS13675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SPRI_RS13680	COG0732	type I restriction modification DNA specificity domain
SPRI_RS13765	COG4974	Belongs to the 'phage' integrase family
SPRI_RS13770	COG0012	GTP binding
SPRI_RS13785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPRI_RS13795	COG1570	exodeoxyribonuclease VII activity
SPRI_RS13800	COG1722	exodeoxyribonuclease VII activity
SPRI_RS13805	COG0778	Nitroreductase
SPRI_RS13840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SPRI_RS13840	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SPRI_RS13850	COG1595	DNA-templated transcription, initiation
SPRI_RS13860	COG0114	fumarate hydratase activity
SPRI_RS13875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_RS13895	COG1136	(ABC) transporter
SPRI_RS13910	COG0450	alkyl hydroperoxide reductase
SPRI_RS13915	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_RS13935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SPRI_RS13940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPRI_RS13945	COG0667	Aldo Keto reductase
SPRI_RS13975	COG2885	chlorophyll binding
SPRI_RS14020	COG0489	protein tyrosine kinase activity
SPRI_RS14060	COG2610	gluconate transmembrane transporter activity
SPRI_RS14065	COG0251	oxidation-reduction process
SPRI_RS14070	COG1414	Transcriptional regulator
SPRI_RS14085	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SPRI_RS14155	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS14180	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS14215	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_RS14235	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SPRI_RS14245	COG0477	Major facilitator Superfamily
SPRI_RS14250	COG1309	transcriptional regulator
SPRI_RS14265	COG0463	Glycosyl transferase, family 2
SPRI_RS14280	COG1331	Highly conserved protein containing a thioredoxin domain
SPRI_RS14305	COG0583	DNA-binding transcription factor activity
SPRI_RS14320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SPRI_RS14330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPRI_RS14345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPRI_RS14355	COG1595	DNA-templated transcription, initiation
SPRI_RS14380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPRI_RS14395	COG0488	(ABC) transporter
SPRI_RS14415	COG1376	ErfK ybiS ycfS ynhG family protein
SPRI_RS14430	COG2986	histidine ammonia-lyase
SPRI_RS14440	COG1024	Enoyl-CoA hydratase
SPRI_RS14455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_RS14475	COG0424	maF-like protein
SPRI_RS14485	COG4770	biotin carboxylase activity
SPRI_RS14515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPRI_RS14530	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS14550	COG1595	DNA-templated transcription, initiation
SPRI_RS14555	COG0745	RESPONSE REGULATOR receiver
SPRI_RS14560	COG2205	protein histidine kinase activity
SPRI_RS14585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_RS14600	COG0583	DNA-binding transcription factor activity
SPRI_RS14605	COG2814	Major facilitator Superfamily
SPRI_RS14630	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPRI_RS14640	COG3845	ABC transporter
SPRI_RS14645	COG1744	ABC transporter substrate-binding protein PnrA-like
SPRI_RS14650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_RS14650	COG1473	amidohydrolase
SPRI_RS14660	COG2089	acid synthase
SPRI_RS14675	COG1216	Glycosyl transferase, family 2
SPRI_RS14690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS14690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS14705	COG1595	DNA-templated transcription, initiation
SPRI_RS14765	COG0681	Belongs to the peptidase S26 family
SPRI_RS14835	COG2009	succinate dehydrogenase
SPRI_RS14845	COG1053	succinate dehydrogenase
SPRI_RS14850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPRI_RS14875	COG0596	Alpha beta hydrolase
SPRI_RS14890	COG1309	transcriptional regulator
SPRI_RS14895	COG1408	metallophosphoesterase
SPRI_RS14905	COG1686	Belongs to the peptidase S11 family
SPRI_RS14920	COG0180	Tryptophanyl-tRNA synthetase
SPRI_RS14925	COG1595	DNA-templated transcription, initiation
SPRI_RS14940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPRI_RS14945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_RS14950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPRI_RS14955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_RS14975	COG4176	ABC-type proline glycine betaine transport system permease component
SPRI_RS14980	COG0517	IMP dehydrogenase activity
SPRI_RS14980	COG4175	Glycine betaine
SPRI_RS14990	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS15025	COG0039	L-malate dehydrogenase activity
SPRI_RS15035	COG0538	isocitrate dehydrogenase activity
SPRI_RS15045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPRI_RS15075	COG0138	bifunctional purine biosynthesis protein purh
SPRI_RS15105	COG0045	succinate-CoA ligase (ADP-forming) activity
SPRI_RS15120	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SPRI_RS15125	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SPRI_RS15130	COG0714	Associated with various cellular activities
SPRI_RS15150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPRI_RS15180	COG0791	NLP P60 protein
SPRI_RS15190	COG2197	response regulator
SPRI_RS15220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPRI_RS15220	COG0519	Catalyzes the synthesis of GMP from XMP
SPRI_RS15240	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS15245	COG0515	serine threonine protein kinase
SPRI_RS15260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPRI_RS15275	COG0516	GMP reductase activity
SPRI_RS15285	COG1595	DNA-templated transcription, initiation
SPRI_RS15290	COG2197	response regulator
SPRI_RS15300	COG0583	DNA-binding transcription factor activity
SPRI_RS15310	COG4221	oxidoreductase activity
SPRI_RS15320	COG0459	protein refolding
SPRI_RS15330	COG0726	polysaccharide deacetylase
SPRI_RS15380	COG4941	Belongs to the sigma-70 factor family
SPRI_RS15395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPRI_RS15415	COG0802	atpase or kinase
SPRI_RS15425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPRI_RS15435	COG0736	holo-[acyl-carrier-protein] synthase activity
SPRI_RS15440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPRI_RS15460	COG1072	(Pantothenic acid kinase))
SPRI_RS15470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPRI_RS15475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPRI_RS15480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPRI_RS15485	COG0488	(ABC) transporter
SPRI_RS15500	COG0101	tRNA pseudouridine synthase activity
SPRI_RS15505	COG0203	ribosomal protein L17
SPRI_RS15510	COG0202	RNA polymerase activity
SPRI_RS15515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPRI_RS15520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPRI_RS15525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPRI_RS15530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPRI_RS15540	COG0563	adenylate kinase activity
SPRI_RS15550	COG0200	Binds to the 23S rRNA
SPRI_RS15555	COG1841	ribosomal large subunit assembly
SPRI_RS15560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPRI_RS15565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SPRI_RS15570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPRI_RS15575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPRI_RS15580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPRI_RS15585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SPRI_RS15590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPRI_RS15595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPRI_RS15600	COG0255	Belongs to the universal ribosomal protein uL29 family
SPRI_RS15605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPRI_RS15610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPRI_RS15615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPRI_RS15620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPRI_RS15625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPRI_RS15630	COG0089	rRNA binding
SPRI_RS15635	COG0088	Forms part of the polypeptide exit tunnel
SPRI_RS15640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPRI_RS15645	COG0051	transcription antitermination factor activity, RNA binding
SPRI_RS15665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPRI_RS15670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPRI_RS15675	COG0049	tRNA binding
SPRI_RS15680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPRI_RS15685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPRI_RS15690	COG0085	RNA polymerase activity
SPRI_RS15695	COG0222	ribosome binding
SPRI_RS15700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPRI_RS15715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPRI_RS15725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPRI_RS15735	COG0436	Aminotransferase
SPRI_RS15740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPRI_RS15755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPRI_RS15760	COG0477	Major facilitator Superfamily
SPRI_RS15775	COG2030	dehydratase
SPRI_RS15780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPRI_RS15795	COG0402	S-adenosylhomocysteine deaminase activity
SPRI_RS15825	COG1666	GTP binding
SPRI_RS15830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPRI_RS15840	COG2261	transglycosylase associated protein
SPRI_RS15850	COG3304	Inner membrane component domain
SPRI_RS15855	COG0501	Belongs to the peptidase M48B family
SPRI_RS15860	COG1007	ATP synthesis coupled electron transport
SPRI_RS15875	COG0713	ATP synthesis coupled electron transport
SPRI_RS15880	COG0839	Belongs to the complex I subunit 6 family
SPRI_RS15885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_RS15890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPRI_RS15895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_RS15900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_RS15925	COG0674	pyruvate-flavodoxin oxidoreductase activity
SPRI_RS15925	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SPRI_RS15930	COG1013	pyruvate-flavodoxin oxidoreductase activity
SPRI_RS15935	COG1733	regulation of RNA biosynthetic process
SPRI_RS15940	COG0702	epimerase
SPRI_RS15970	COG4935	Belongs to the peptidase S8 family
SPRI_RS15970	COG2234	aminopeptidase activity
SPRI_RS15980	COG1131	(ABC) transporter
SPRI_RS15990	COG0142	geranyltranstransferase activity
SPRI_RS16010	COG2207	Transcriptional regulator
SPRI_RS16010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPRI_RS16015	COG1007	ATP synthesis coupled electron transport
SPRI_RS16025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPRI_RS16030	COG0713	ATP synthesis coupled electron transport
SPRI_RS16035	COG0839	Belongs to the complex I subunit 6 family
SPRI_RS16040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_RS16045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPRI_RS16050	COG1034	ATP synthesis coupled electron transport
SPRI_RS16055	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SPRI_RS16065	COG0649	NAD binding
SPRI_RS16070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_RS16075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPRI_RS16115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_RS16140	COG2066	Belongs to the glutaminase family
SPRI_RS16145	COG2226	methyltransferase
SPRI_RS16155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPRI_RS16165	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SPRI_RS16170	COG1278	Cold shock
SPRI_RS16190	COG1309	transcriptional regulator
SPRI_RS16205	COG1301	dicarboxylic acid transport
SPRI_RS16220	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPRI_RS16230	COG0163	prenyltransferase activity
SPRI_RS16240	COG0109	protoheme IX farnesyltransferase activity
SPRI_RS16250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SPRI_RS16260	COG0583	DNA-binding transcription factor activity
SPRI_RS16265	COG0697	spore germination
SPRI_RS16280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPRI_RS16285	COG1333	cytochrome c biogenesis protein
SPRI_RS16295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPRI_RS16305	COG0406	alpha-ribazole phosphatase activity
SPRI_RS16310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPRI_RS16355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_RS16375	COG1690	Belongs to the RtcB family
SPRI_RS16405	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SPRI_RS16410	COG0018	arginyl-trna synthetase
SPRI_RS16430	COG2272	Belongs to the type-B carboxylesterase lipase family
SPRI_RS16460	COG0113	porphobilinogen synthase activity
SPRI_RS16465	COG2226	methyltransferase
SPRI_RS16470	COG1648	precorrin-2 dehydrogenase activity
SPRI_RS16470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPRI_RS16475	COG0181	hydroxymethylbilane synthase activity
SPRI_RS16480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SPRI_RS16485	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPRI_RS16500	COG1595	DNA-templated transcription, initiation
SPRI_RS16530	COG0123	including yeast histone deacetylase and acetoin utilization protein
SPRI_RS16540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_RS16565	COG0180	Tryptophanyl-tRNA synthetase
SPRI_RS16570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPRI_RS16580	COG0842	Transport permease protein
SPRI_RS16580	COG1129	ABC transporter
SPRI_RS16590	COG4991	sh3 domain protein
SPRI_RS16600	COG0129	dihydroxy-acid dehydratase activity
SPRI_RS16610	COG1082	Xylose isomerase domain protein TIM barrel
SPRI_RS16615	COG0248	Ppx GppA phosphatase
SPRI_RS16635	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SPRI_RS16645	COG0671	phosphoesterase, PA-phosphatase related
SPRI_RS16650	COG1194	a g-specific adenine glycosylase
SPRI_RS16655	COG1595	DNA-templated transcription, initiation
SPRI_RS16665	COG0745	RESPONSE REGULATOR receiver
SPRI_RS16670	COG2205	protein histidine kinase activity
SPRI_RS16675	COG0739	heme binding
SPRI_RS16680	COG2027	D-alanyl-D-alanine carboxypeptidase
SPRI_RS16700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPRI_RS16715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SPRI_RS16725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SPRI_RS16730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SPRI_RS16750	COG0640	Transcriptional regulator
SPRI_RS16755	COG2197	response regulator
SPRI_RS16770	COG0649	NAD binding
SPRI_RS16780	COG1732	Glycine betaine
SPRI_RS16785	COG1174	glycine betaine transport
SPRI_RS16795	COG0517	IMP dehydrogenase activity
SPRI_RS16795	COG1125	glycine betaine transport
SPRI_RS16805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SPRI_RS16805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SPRI_RS16820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPRI_RS16835	COG0667	Aldo Keto reductase
SPRI_RS16840	COG0302	gtp cyclohydrolase
SPRI_RS16855	COG0037	tRNA processing
SPRI_RS16865	COG2027	D-alanyl-D-alanine carboxypeptidase
SPRI_RS16870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SPRI_RS16880	COG0586	Pfam SNARE associated Golgi protein
SPRI_RS16885	COG0393	Putative heavy-metal-binding
SPRI_RS16890	COG0789	Transcriptional regulator
SPRI_RS16895	COG0076	glutamate decarboxylase activity
SPRI_RS16915	COG2318	DinB family
SPRI_RS16920	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS16940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPRI_RS16950	COG0254	rRNA binding
SPRI_RS16955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPRI_RS16960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPRI_RS16965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPRI_RS16985	COG1136	(ABC) transporter
SPRI_RS16985	COG0577	efflux transmembrane transporter activity
SPRI_RS16990	COG0577	efflux transmembrane transporter activity
SPRI_RS17000	COG0110	maltose O-acetyltransferase activity
SPRI_RS17005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPRI_RS17005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPRI_RS17020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPRI_RS17030	COG0583	DNA-binding transcription factor activity
SPRI_RS17045	COG2175	clavaminate synthase activity
SPRI_RS17050	COG0527	aspartate kinase activity
SPRI_RS17055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPRI_RS17060	COG0697	spore germination
SPRI_RS17065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_RS17070	COG4865	methylaspartate mutase activity
SPRI_RS17085	COG0439	Biotin carboxylase
SPRI_RS17090	COG0511	ligase activity, forming carbon-carbon bonds
SPRI_RS17095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPRI_RS17095	COG0825	malonyl-CoA metabolic process
SPRI_RS17135	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS17140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPRI_RS17140	COG2070	2-Nitropropane dioxygenase
SPRI_RS17150	COG0604	alcohol dehydrogenase
SPRI_RS17150	COG3321	synthase
SPRI_RS17165	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SPRI_RS17175	COG0477	Major facilitator Superfamily
SPRI_RS17185	COG0475	glutathione-regulated potassium exporter activity
SPRI_RS17205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPRI_RS17250	COG0470	DNA polymerase III
SPRI_RS17255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPRI_RS17260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPRI_RS17260	COG1754	DNA topoisomerase type I activity
SPRI_RS17270	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_RS17280	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SPRI_RS17285	COG2172	sigma factor antagonist activity
SPRI_RS17290	COG1366	Belongs to the anti-sigma-factor antagonist family
SPRI_RS17295	COG1205	dead DEAH box helicase
SPRI_RS17295	COG1111	helicase
SPRI_RS17355	COG0659	secondary active sulfate transmembrane transporter activity
SPRI_RS17360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_RS17365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPRI_RS17375	COG2267	carboxylic ester hydrolase activity
SPRI_RS17405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPRI_RS17425	COG0003	Pfam Anion-transporting ATPase
SPRI_RS17435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_RS17440	COG1610	YqeY-like protein
SPRI_RS17455	COG1408	metallophosphoesterase
SPRI_RS17515	COG1595	DNA-templated transcription, initiation
SPRI_RS17535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPRI_RS17540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPRI_RS17555	COG1802	Transcriptional regulator
SPRI_RS17570	COG0693	protein deglycase activity
SPRI_RS17600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPRI_RS17610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPRI_RS17625	COG1131	(ABC) transporter
SPRI_RS17630	COG3559	Exporter of polyketide antibiotics
SPRI_RS17635	COG2124	cytochrome p450
SPRI_RS17640	COG2197	response regulator
SPRI_RS17645	COG4585	Histidine kinase
SPRI_RS17660	COG3844	kynureninase activity
SPRI_RS17680	COG0477	Major facilitator Superfamily
SPRI_RS17685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPRI_RS17690	COG0191	fructose-bisphosphate aldolase activity
SPRI_RS17695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPRI_RS17710	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPRI_RS17735	COG0542	response to heat
SPRI_RS17770	COG0789	Transcriptional regulator
SPRI_RS17775	COG0484	heat shock protein binding
SPRI_RS17780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPRI_RS17785	COG0443	Heat shock 70 kDa protein
SPRI_RS17790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPRI_RS17795	COG0247	lactate metabolic process
SPRI_RS17795	COG2181	nitrate reductase activity
SPRI_RS17815	COG0717	Belongs to the dCTP deaminase family
SPRI_RS17835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPRI_RS17900	COG2197	response regulator
SPRI_RS17920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SPRI_RS17925	COG3958	Transketolase
SPRI_RS17930	COG3959	Transketolase, thiamine diphosphate binding domain
SPRI_RS17935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPRI_RS17940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SPRI_RS17955	COG0189	ligase activity
SPRI_RS17970	COG1115	amino acid carrier protein
SPRI_RS18015	COG3509	depolymerase
SPRI_RS18030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPRI_RS18050	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPRI_RS18050	COG1902	pentaerythritol trinitrate reductase activity
SPRI_RS18105	COG1289	transmembrane transporter activity
SPRI_RS18130	COG2304	oxidoreductase activity
SPRI_RS18135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_RS18155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPRI_RS18170	COG1741	Belongs to the pirin family
SPRI_RS18180	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS18185	COG1362	aminopeptidase activity
SPRI_RS18220	COG2271	Major facilitator Superfamily
SPRI_RS18230	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPRI_RS18235	COG0022	dehydrogenase e1 component
SPRI_RS18260	COG0515	serine threonine protein kinase
SPRI_RS18265	COG0515	serine threonine protein kinase
SPRI_RS18280	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPRI_RS18280	COG1136	(ABC) transporter
SPRI_RS18295	COG0604	alcohol dehydrogenase
SPRI_RS18300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPRI_RS18330	COG1522	sequence-specific DNA binding
SPRI_RS18335	COG1309	transcriptional regulator
SPRI_RS18340	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPRI_RS18365	COG3396	Phenylacetate-CoA oxygenase
SPRI_RS18370	COG3460	Phenylacetate-CoA oxygenase
SPRI_RS18375	COG3396	Phenylacetate-CoA oxygenase
SPRI_RS18380	COG2151	metal-sulfur cluster biosynthetic enzyme
SPRI_RS18385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPRI_RS18390	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS18395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPRI_RS18415	COG1716	ATPase activity
SPRI_RS18420	COG1716	ATPase activity
SPRI_RS18435	COG0768	penicillin binding
SPRI_RS18440	COG0515	serine threonine protein kinase
SPRI_RS18445	COG3764	Sortase (surface protein transpeptidase)
SPRI_RS18450	COG3764	Sortase (surface protein transpeptidase)
SPRI_RS18460	COG3764	Sortase (surface protein transpeptidase)
SPRI_RS18475	COG0457	Tetratricopeptide repeat
SPRI_RS18475	COG0705	Rhomboid family
SPRI_RS18520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPRI_RS18525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS18530	COG1132	(ABC) transporter
SPRI_RS18540	COG4152	abc transporter atp-binding protein
SPRI_RS18590	COG0515	serine threonine protein kinase
SPRI_RS18615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPRI_RS18625	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SPRI_RS18630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPRI_RS18635	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SPRI_RS18640	COG0592	DNA-directed DNA polymerase activity
SPRI_RS18645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPRI_RS18650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SPRI_RS18655	COG0594	ribonuclease P activity
SPRI_RS18660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPRI_RS18665	COG0706	membrane insertase activity
SPRI_RS18675	COG0357	Ribosomal RNA small subunit methyltransferase G
SPRI_RS18680	COG1192	Involved in chromosome partitioning
SPRI_RS18695	COG3118	belongs to the thioredoxin family
SPRI_RS18700	COG0492	ferredoxin-NADP+ reductase activity
SPRI_RS18710	COG1595	DNA-templated transcription, initiation
SPRI_RS18715	COG2815	serine threonine protein kinase
SPRI_RS18715	COG0515	serine threonine protein kinase
SPRI_RS18730	COG0617	tRNA 3'-terminal CCA addition
SPRI_RS18755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_RS18780	COG0360	Binds together with S18 to 16S ribosomal RNA
SPRI_RS18785	COG0629	single-stranded DNA binding
SPRI_RS18790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPRI_RS18795	COG0359	binds to the 23S rRNA
SPRI_RS18805	COG0305	Participates in initiation and elongation during chromosome replication
SPRI_RS18815	COG2814	Major facilitator Superfamily
SPRI_RS18850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPRI_RS18890	COG0626	cystathionine gamma-synthase activity
SPRI_RS18895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPRI_RS18900	COG1950	PFAM Membrane protein of
SPRI_RS18905	COG0662	Cupin 2, conserved barrel domain protein
SPRI_RS18930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPRI_RS18945	COG1609	Transcriptional regulator
SPRI_RS18950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPRI_RS18955	COG1271	oxidase subunit
SPRI_RS18960	COG1294	oxidase, subunit
SPRI_RS18965	COG4988	ABC transporter
SPRI_RS18975	COG0741	lytic transglycosylase activity
SPRI_RS18975	COG1196	nuclear chromosome segregation
SPRI_RS18975	COG0739	heme binding
SPRI_RS18980	COG0561	phosphatase activity
SPRI_RS18990	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SPRI_RS18995	COG0789	Transcriptional regulator
SPRI_RS19005	COG1131	(ABC) transporter
SPRI_RS19030	COG0561	phosphatase activity
SPRI_RS19035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPRI_RS19045	COG2837	iron assimilation
SPRI_RS19050	COG2372	response to copper ion
SPRI_RS19060	COG1999	signal sequence binding
SPRI_RS19080	COG0006	proline dipeptidase activity
SPRI_RS19115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_RS19135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SPRI_RS19165	COG1595	DNA-templated transcription, initiation
SPRI_RS19170	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS19175	COG0784	Response regulator, receiver
SPRI_RS19215	COG1404	Belongs to the peptidase S8 family
SPRI_RS19225	COG0745	RESPONSE REGULATOR receiver
SPRI_RS19230	COG2205	protein histidine kinase activity
SPRI_RS19240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SPRI_RS19240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SPRI_RS19245	COG0477	Major facilitator Superfamily
SPRI_RS19255	COG3467	pyridoxamine 5'-phosphate
SPRI_RS19260	COG2353	YceI-like domain
SPRI_RS19285	COG1191	sigma factor activity
SPRI_RS19290	COG1191	sigma factor activity
SPRI_RS19320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPRI_RS19345	COG4941	Belongs to the sigma-70 factor family
SPRI_RS19385	COG0151	Belongs to the GarS family
SPRI_RS19400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPRI_RS19425	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPRI_RS19430	COG0047	phosphoribosylformylglycinamidine synthase activity
SPRI_RS19435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPRI_RS19465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPRI_RS19475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPRI_RS19495	COG1643	Atp-dependent helicase
SPRI_RS19505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPRI_RS19505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SPRI_RS19510	COG0785	Cytochrome C biogenesis protein
SPRI_RS19540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPRI_RS19545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPRI_RS19570	COG2226	methyltransferase
SPRI_RS19575	COG1959	2 iron, 2 sulfur cluster binding
SPRI_RS19580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPRI_RS19580	COG1017	nitric oxide dioxygenase activity
SPRI_RS19595	COG0739	heme binding
SPRI_RS19595	COG0741	lytic transglycosylase activity
SPRI_RS19595	COG1196	nuclear chromosome segregation
SPRI_RS19600	COG0667	Aldo Keto reductase
SPRI_RS19610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPRI_RS19615	COG0579	oxidoreductase
SPRI_RS19640	COG1252	NADH dehydrogenase
SPRI_RS19655	COG1846	Transcriptional regulator
SPRI_RS19680	COG2197	response regulator
SPRI_RS19685	COG4585	Histidine kinase
SPRI_RS19695	COG1131	(ABC) transporter
SPRI_RS19740	COG1196	nuclear chromosome segregation
SPRI_RS19740	COG0739	heme binding
SPRI_RS19740	COG0741	lytic transglycosylase activity
SPRI_RS19745	COG0671	phosphoesterase, PA-phosphatase related
SPRI_RS19750	COG0277	FAD linked oxidase domain protein
SPRI_RS19760	COG1937	Protein conserved in bacteria
SPRI_RS19770	COG0306	phosphate transporter
SPRI_RS19775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPRI_RS19790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPRI_RS19795	COG0406	alpha-ribazole phosphatase activity
SPRI_RS19795	COG0494	nUDIX hydrolase
SPRI_RS19805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPRI_RS19815	COG1131	(ABC) transporter
SPRI_RS19820	COG1725	Transcriptional regulator
SPRI_RS19825	COG0456	acetyltransferase
SPRI_RS19830	COG0737	Belongs to the 5'-nucleotidase family
SPRI_RS19840	COG0488	(ABC) transporter
SPRI_RS19855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_RS19860	COG1609	Transcriptional regulator
SPRI_RS19865	COG0745	RESPONSE REGULATOR receiver
SPRI_RS19890	COG2897	thiosulfate sulfurtransferase activity
SPRI_RS19925	COG3485	protocatechuate 3,4-dioxygenase
SPRI_RS19935	COG0354	folic acid binding
SPRI_RS19940	COG1490	D-aminoacyl-tRNA deacylase activity
SPRI_RS19955	COG4552	Acetyltransferase involved in intracellular survival and related
SPRI_RS19970	COG2188	Transcriptional regulator
SPRI_RS20005	COG0667	Aldo Keto reductase
SPRI_RS20050	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS20080	COG0588	phosphoglycerate mutase activity
SPRI_RS20090	COG4974	Belongs to the 'phage' integrase family
SPRI_RS20140	COG5002	protein histidine kinase activity
SPRI_RS20155	COG1329	Transcriptional regulator
SPRI_RS20160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPRI_RS20165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPRI_RS20170	COG0215	cysteine-tRNA ligase activity
SPRI_RS20195	COG3842	ATPase activity
SPRI_RS20210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_RS20245	COG2197	response regulator
SPRI_RS20250	COG4191	Histidine kinase
SPRI_RS20270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPRI_RS20290	COG1105	Belongs to the carbohydrate kinase PfkB family
SPRI_RS20295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPRI_RS20315	COG1877	trehalose-phosphatase activity
SPRI_RS20315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_RS20330	COG0463	Glycosyl transferase, family 2
SPRI_RS20395	COG1136	(ABC) transporter
SPRI_RS20415	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SPRI_RS20420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SPRI_RS20455	COG3973	AAA domain
SPRI_RS20460	COG1122	ATPase activity
SPRI_RS20480	COG1061	Type III restriction enzyme res subunit
SPRI_RS20500	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SPRI_RS20505	COG1120	ATPase activity
SPRI_RS20510	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS20515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS20530	COG1278	Cold shock
SPRI_RS20535	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SPRI_RS20540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPRI_RS20550	COG2814	Major facilitator Superfamily
SPRI_RS20590	COG1136	(ABC) transporter
SPRI_RS20590	COG0577	efflux transmembrane transporter activity
SPRI_RS20595	COG4585	Histidine kinase
SPRI_RS20600	COG2197	response regulator
SPRI_RS20625	COG1366	Belongs to the anti-sigma-factor antagonist family
SPRI_RS20635	COG0596	Alpha beta hydrolase
SPRI_RS20655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPRI_RS20665	COG2252	PERMEase
SPRI_RS20690	COG0667	Aldo Keto reductase
SPRI_RS20775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPRI_RS20785	COG0247	lactate metabolic process
SPRI_RS20785	COG0277	FAD linked oxidase domain protein
SPRI_RS20795	COG0259	pyridoxamine-phosphate oxidase activity
SPRI_RS20800	COG0583	DNA-binding transcription factor activity
SPRI_RS20805	COG5006	permease, DMT superfamily
SPRI_RS20830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_RS20845	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS20850	COG1024	Enoyl-CoA hydratase
SPRI_RS20865	COG0259	pyridoxamine-phosphate oxidase activity
SPRI_RS20880	COG4821	SIS domain
SPRI_RS20890	COG0596	Alpha beta hydrolase
SPRI_RS20890	COG2945	thiolester hydrolase activity
SPRI_RS20945	COG1653	transport
SPRI_RS21000	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS21010	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS21015	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS21030	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS21035	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS21040	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SPRI_RS21060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPRI_RS21065	COG1024	Enoyl-CoA hydratase
SPRI_RS21075	COG2072	flavoprotein involved in K transport
SPRI_RS21090	COG0259	pyridoxamine-phosphate oxidase activity
SPRI_RS21100	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS21125	COG1309	transcriptional regulator
SPRI_RS21135	COG1024	Enoyl-CoA hydratase
SPRI_RS21150	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS21235	COG0531	amino acid
SPRI_RS21300	COG3209	COG3209 Rhs family protein
SPRI_RS21350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPRI_RS21365	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS21390	COG1686	Belongs to the peptidase S11 family
SPRI_RS21415	COG0456	acetyltransferase
SPRI_RS21440	COG1309	transcriptional regulator
SPRI_RS21485	COG1846	Transcriptional regulator
SPRI_RS21490	COG3384	dioxygenase
SPRI_RS21495	COG1247	-acetyltransferase
SPRI_RS21510	COG0477	Major facilitator Superfamily
SPRI_RS21530	COG1970	mechanosensitive ion channel activity
SPRI_RS21540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPRI_RS21560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPRI_RS21565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPRI_RS21575	COG0315	cyclic pyranopterin monophosphate synthase activity
SPRI_RS21580	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPRI_RS21585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPRI_RS21635	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS21640	COG2267	carboxylic ester hydrolase activity
SPRI_RS21645	COG2072	flavoprotein involved in K transport
SPRI_RS21655	COG0793	Belongs to the peptidase S41A family
SPRI_RS21655	COG4946	Tricorn protease homolog
SPRI_RS21665	COG2409	Drug exporters of the RND superfamily
SPRI_RS21675	COG0310	cobalt ion transport
SPRI_RS21685	COG1122	ATPase activity
SPRI_RS21695	COG1764	response to oxidative stress
SPRI_RS21700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_RS21715	COG0442	prolyl-tRNA aminoacylation
SPRI_RS21745	COG0084	hydrolase, TatD family'
SPRI_RS21755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPRI_RS21760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPRI_RS21770	COG0488	(ABC) transporter
SPRI_RS21800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPRI_RS21805	COG2197	response regulator
SPRI_RS21810	COG1846	Transcriptional regulator
SPRI_RS21815	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_RS21835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPRI_RS21855	COG0193	aminoacyl-tRNA hydrolase activity
SPRI_RS21860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SPRI_RS21865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPRI_RS21870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPRI_RS21905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_RS21920	COG0477	Major facilitator Superfamily
SPRI_RS21925	COG1136	(ABC) transporter
SPRI_RS21930	COG0577	efflux transmembrane transporter activity
SPRI_RS21985	COG0463	Glycosyl transferase, family 2
SPRI_RS21995	COG0596	Alpha beta hydrolase
SPRI_RS22005	COG1215	transferase activity, transferring glycosyl groups
SPRI_RS22020	COG2124	cytochrome p450
SPRI_RS22035	COG0148	phosphopyruvate hydratase activity
SPRI_RS22060	COG1252	NADH dehydrogenase
SPRI_RS22065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SPRI_RS22070	COG0577	efflux transmembrane transporter activity
SPRI_RS22070	COG1136	(ABC) transporter
SPRI_RS22075	COG1136	(ABC) transporter
SPRI_RS22105	COG0183	Belongs to the thiolase family
SPRI_RS22110	COG2755	lipolytic protein G-D-S-L family
SPRI_RS22165	COG0019	diaminopimelate decarboxylase activity
SPRI_RS22170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPRI_RS22185	COG1228	amidohydrolase
SPRI_RS22195	COG1794	racemase activity, acting on amino acids and derivatives
SPRI_RS22215	COG1191	sigma factor activity
SPRI_RS22255	COG3104	oligopeptide transport
SPRI_RS22260	COG0745	RESPONSE REGULATOR receiver
SPRI_RS22265	COG2205	protein histidine kinase activity
SPRI_RS22280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPRI_RS22305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPRI_RS22320	COG1316	TRANSCRIPTIONal
SPRI_RS22325	COG1607	acyl-coa hydrolase
SPRI_RS22330	COG1316	TRANSCRIPTIONal
SPRI_RS22345	COG1316	TRANSCRIPTIONal
SPRI_RS22375	COG0778	Nitroreductase
SPRI_RS22375	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SPRI_RS22380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPRI_RS22415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPRI_RS22420	COG2835	tetraacyldisaccharide 4'-kinase activity
SPRI_RS22430	COG1482	cell wall glycoprotein biosynthetic process
SPRI_RS22440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SPRI_RS22485	COG0714	Associated with various cellular activities
SPRI_RS22505	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SPRI_RS22510	COG0745	RESPONSE REGULATOR receiver
SPRI_RS22515	COG5002	protein histidine kinase activity
SPRI_RS22515	COG5000	phosphorelay sensor kinase activity
SPRI_RS22520	COG0823	Involved in the tonB-independent uptake of proteins
SPRI_RS22530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SPRI_RS22540	COG3214	Protein conserved in bacteria
SPRI_RS22550	COG0653	protein targeting
SPRI_RS22575	COG2902	Dehydrogenase
SPRI_RS22585	COG1134	teichoic acid transport
SPRI_RS22585	COG1388	LysM domain
SPRI_RS22595	COG1309	transcriptional regulator
SPRI_RS22615	COG0395	ABC-type sugar transport system, permease component
SPRI_RS22620	COG1175	transmembrane transport
SPRI_RS22625	COG1653	transport
SPRI_RS22630	COG1674	ftsk spoiiie
SPRI_RS22635	COG0515	serine threonine protein kinase
SPRI_RS22640	COG0515	serine threonine protein kinase
SPRI_RS22645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPRI_RS22660	COG2884	Cell division ATP-binding protein ftsE
SPRI_RS22670	COG3409	Peptidoglycan-binding domain 1 protein
SPRI_RS22670	COG0793	Belongs to the peptidase S41A family
SPRI_RS22675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPRI_RS22685	COG0583	DNA-binding transcription factor activity
SPRI_RS22735	COG3973	AAA domain
SPRI_RS22745	COG0776	regulation of translation
SPRI_RS22750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPRI_RS22755	COG1678	Uncharacterized ACR, COG1678
SPRI_RS22770	COG1175	transmembrane transport
SPRI_RS22775	COG0395	ABC-type sugar transport system, permease component
SPRI_RS22780	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_RS22810	COG1404	Belongs to the peptidase S8 family
SPRI_RS22820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPRI_RS22820	COG0515	serine threonine protein kinase
SPRI_RS22905	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SPRI_RS22915	COG0277	FAD linked oxidase domain protein
SPRI_RS22950	COG1335	isochorismatase
SPRI_RS22960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SPRI_RS22970	COG1113	amino acid transport
SPRI_RS22990	COG1234	tRNA 3'-trailer cleavage
SPRI_RS22995	COG1263	PTS System
SPRI_RS23000	COG1263	PTS System
SPRI_RS23005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPRI_RS23010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SPRI_RS23020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPRI_RS23040	COG0477	Major facilitator Superfamily
SPRI_RS23055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPRI_RS23065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPRI_RS23080	COG4555	ABC transporter
SPRI_RS23095	COG2733	membrane
SPRI_RS23150	COG1074	ATP-dependent DNA helicase activity
SPRI_RS23215	COG3764	Sortase (surface protein transpeptidase)
SPRI_RS23220	COG4213	ABC transporter substrate-binding protein
SPRI_RS23235	COG1742	UPF0060 membrane protein
SPRI_RS23245	COG4702	Belongs to the UPF0303 family
SPRI_RS23250	COG0673	inositol 2-dehydrogenase activity
SPRI_RS23330	COG1126	abc transporter atp-binding protein
SPRI_RS23335	COG0765	amino acid transport
SPRI_RS23340	COG0765	amino acid transport
SPRI_RS23345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_RS23355	COG0154	amidase activity
SPRI_RS23375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPRI_RS23385	COG1175	transmembrane transport
SPRI_RS23400	COG1349	DNA-binding transcription factor activity
SPRI_RS23410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS23505	COG0395	ABC-type sugar transport system, permease component
SPRI_RS23510	COG1175	transmembrane transport
SPRI_RS23525	COG0789	Transcriptional regulator
SPRI_RS23540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_RS23545	COG1595	DNA-templated transcription, initiation
SPRI_RS23560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SPRI_RS23565	COG4977	sequence-specific DNA binding
SPRI_RS23575	COG0589	response to stress
SPRI_RS23585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPRI_RS23610	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SPRI_RS23620	COG2375	cellular response to nickel ion
SPRI_RS23630	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS23645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_RS23650	COG1309	transcriptional regulator
SPRI_RS23665	COG2197	response regulator
SPRI_RS23670	COG4585	Histidine kinase
SPRI_RS23675	COG1946	Acyl-CoA thioesterase
SPRI_RS23700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_RS23710	COG0028	Belongs to the TPP enzyme family
SPRI_RS23715	COG2197	response regulator
SPRI_RS23720	COG4585	Histidine kinase
SPRI_RS23725	COG1131	(ABC) transporter
SPRI_RS23770	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_RS23800	COG1846	Transcriptional regulator
SPRI_RS23800	COG0456	acetyltransferase
SPRI_RS23815	COG1609	Transcriptional regulator
SPRI_RS23820	COG0673	inositol 2-dehydrogenase activity
SPRI_RS23870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPRI_RS23900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS23910	COG3718	enzyme involved in inositol metabolism
SPRI_RS23915	COG3962	Belongs to the TPP enzyme family
SPRI_RS23940	COG1131	(ABC) transporter
SPRI_RS24005	COG0629	single-stranded DNA binding
SPRI_RS24030	COG0577	efflux transmembrane transporter activity
SPRI_RS24030	COG1136	(ABC) transporter
SPRI_RS24080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_RS24095	COG1486	melibiose metabolic process
SPRI_RS24100	COG0395	ABC-type sugar transport system, permease component
SPRI_RS24105	COG1175	transmembrane transport
SPRI_RS24120	COG0668	transmembrane transport
SPRI_RS24130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPRI_RS24160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_RS24180	COG5002	protein histidine kinase activity
SPRI_RS24205	COG0494	nUDIX hydrolase
SPRI_RS24220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SPRI_RS24225	COG1113	amino acid transport
SPRI_RS24230	COG1113	amino acid transport
SPRI_RS24240	COG1113	amino acid transport
SPRI_RS24255	COG4552	Acetyltransferase involved in intracellular survival and related
SPRI_RS24265	COG0475	glutathione-regulated potassium exporter activity
SPRI_RS24270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPRI_RS24275	COG3594	Acyltransferase
SPRI_RS24315	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPRI_RS24320	COG0740	serine-type endopeptidase activity
SPRI_RS24325	COG0740	serine-type endopeptidase activity
SPRI_RS24330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SPRI_RS24340	COG0525	valine-tRNA ligase activity
SPRI_RS24345	COG0285	dihydrofolate synthase activity
SPRI_RS24355	COG0105	UTP biosynthetic process
SPRI_RS24360	COG1077	Cell shape determining protein MreB Mrl
SPRI_RS24375	COG0768	penicillin binding
SPRI_RS24380	COG0772	Belongs to the SEDS family
SPRI_RS24415	COG1530	ribonuclease E activity
SPRI_RS24420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPRI_RS24425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPRI_RS24430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPRI_RS24435	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS24440	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS24450	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS24465	COG1216	Glycosyl transferase, family 2
SPRI_RS24490	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SPRI_RS24500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPRI_RS24510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPRI_RS24525	COG0501	Belongs to the peptidase M48B family
SPRI_RS24530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPRI_RS24540	COG0799	negative regulation of ribosome biogenesis
SPRI_RS24545	COG0588	phosphoglycerate mutase activity
SPRI_RS24565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SPRI_RS24575	COG0495	leucyl-tRNA aminoacylation
SPRI_RS24585	COG1307	EDD domain protein, DegV family
SPRI_RS24590	COG1555	photosystem II stabilization
SPRI_RS24590	COG1596	polysaccharide export
SPRI_RS24605	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SPRI_RS24620	COG0268	Binds directly to 16S ribosomal RNA
SPRI_RS24625	COG0481	GTPase activity
SPRI_RS24655	COG1420	regulation of RNA biosynthetic process
SPRI_RS24660	COG0484	heat shock protein binding
SPRI_RS24685	COG0793	Belongs to the peptidase S41A family
SPRI_RS24685	COG4946	Tricorn protease homolog
SPRI_RS24690	COG0537	adenosine 5'-monophosphoramidase activity
SPRI_RS24695	COG1234	tRNA 3'-trailer cleavage
SPRI_RS24710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS24720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPRI_RS24730	COG2315	Protein conserved in bacteria
SPRI_RS24750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPRI_RS24765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPRI_RS24775	COG2409	Drug exporters of the RND superfamily
SPRI_RS24780	COG4585	Histidine kinase
SPRI_RS24785	COG2197	response regulator
SPRI_RS24805	COG1381	Involved in DNA repair and RecF pathway recombination
SPRI_RS24810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPRI_RS24860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPRI_RS24865	COG1121	(ABC) transporter
SPRI_RS24870	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPRI_RS24870	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPRI_RS24875	COG0423	glycine-tRNA ligase activity
SPRI_RS24900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPRI_RS24900	COG0574	Belongs to the PEP-utilizing enzyme family
SPRI_RS24925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPRI_RS24925	COG2146	nitrite reductase [NAD(P)H] activity
SPRI_RS24930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPRI_RS24985	COG0243	molybdopterin cofactor binding
SPRI_RS24995	COG2949	membrane
SPRI_RS25010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SPRI_RS25020	COG0358	DNA primase activity
SPRI_RS25035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPRI_RS25050	COG1070	Carbohydrate kinase
SPRI_RS25095	COG1404	Belongs to the peptidase S8 family
SPRI_RS25100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPRI_RS25100	COG0825	malonyl-CoA metabolic process
SPRI_RS25105	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS25115	COG1077	Cell shape determining protein MreB Mrl
SPRI_RS25135	COG2130	NADP-dependent
SPRI_RS25140	COG1764	response to oxidative stress
SPRI_RS25175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS25180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS25185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS25200	COG1741	Belongs to the pirin family
SPRI_RS25210	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPRI_RS25250	COG0745	RESPONSE REGULATOR receiver
SPRI_RS25255	COG2205	protein histidine kinase activity
SPRI_RS25275	COG0789	Transcriptional regulator
SPRI_RS25280	COG0667	Aldo Keto reductase
SPRI_RS25295	COG2197	response regulator
SPRI_RS25300	COG4585	Histidine kinase
SPRI_RS25315	COG1309	transcriptional regulator
SPRI_RS25320	COG0477	Major facilitator Superfamily
SPRI_RS25330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_RS25335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SPRI_RS25380	COG1358	cellular component organization or biogenesis
SPRI_RS25390	COG0586	Pfam SNARE associated Golgi protein
SPRI_RS25395	COG4585	Histidine kinase
SPRI_RS25485	COG0500	methyltransferase
SPRI_RS25545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SPRI_RS25590	COG0390	transport system, permease component
SPRI_RS25600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_RS25635	COG4122	O-methyltransferase activity
SPRI_RS25665	COG2367	Beta-lactamase
SPRI_RS25670	COG2124	cytochrome p450
SPRI_RS25675	COG0183	Belongs to the thiolase family
SPRI_RS25685	COG3845	ABC transporter
SPRI_RS25700	COG1657	PFAM Prenyltransferase squalene oxidase
SPRI_RS25730	COG1309	transcriptional regulator
SPRI_RS25735	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS25755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS25765	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPRI_RS25770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SPRI_RS25815	COG0789	Transcriptional regulator
SPRI_RS25830	COG2197	response regulator
SPRI_RS25835	COG4585	Histidine kinase
SPRI_RS25840	COG2030	dehydratase
SPRI_RS25850	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS25860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPRI_RS25865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPRI_RS25890	COG0800	Aldolase
SPRI_RS25895	COG3022	response to hydroperoxide
SPRI_RS25900	COG0557	exoribonuclease II activity
SPRI_RS25920	COG0515	serine threonine protein kinase
SPRI_RS25920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPRI_RS25925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_RS25990	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS25995	COG3540	Alkaline phosphatase
SPRI_RS26005	COG2814	Major facilitator Superfamily
SPRI_RS26075	COG1994	Peptidase M50
SPRI_RS26115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPRI_RS26125	COG2814	Major facilitator Superfamily
SPRI_RS26130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPRI_RS26130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPRI_RS26155	COG2409	Drug exporters of the RND superfamily
SPRI_RS26170	COG0174	glutamine synthetase
SPRI_RS26185	COG2226	methyltransferase
SPRI_RS26195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SPRI_RS26205	COG1609	Transcriptional regulator
SPRI_RS26225	COG2365	Tyrosine phosphatase family
SPRI_RS26245	COG2197	response regulator
SPRI_RS26270	COG0745	RESPONSE REGULATOR receiver
SPRI_RS26310	COG0577	efflux transmembrane transporter activity
SPRI_RS26315	COG1136	(ABC) transporter
SPRI_RS26350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPRI_RS26355	COG0321	lipoyl(octanoyl) transferase activity
SPRI_RS26385	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS26400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SPRI_RS26410	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPRI_RS26415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPRI_RS26420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPRI_RS26440	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SPRI_RS26450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SPRI_RS26465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPRI_RS26470	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_RS26495	COG2197	response regulator
SPRI_RS26500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPRI_RS26505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SPRI_RS26525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS26535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPRI_RS26540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_RS26550	COG1376	ErfK ybiS ycfS ynhG family protein
SPRI_RS26560	COG1845	cytochrome c oxidase, subunit III
SPRI_RS26565	COG2010	Cytochrome c
SPRI_RS26570	COG0723	plastoquinol--plastocyanin reductase activity
SPRI_RS26575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SPRI_RS26580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_RS26585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPRI_RS26590	COG1929	Belongs to the glycerate kinase type-1 family
SPRI_RS26600	COG0745	RESPONSE REGULATOR receiver
SPRI_RS26605	COG2205	protein histidine kinase activity
SPRI_RS26655	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS26675	COG0003	Pfam Anion-transporting ATPase
SPRI_RS26685	COG1940	carbohydrate kinase activity
SPRI_RS26710	COG4585	Histidine kinase
SPRI_RS26715	COG2197	response regulator
SPRI_RS26720	COG0205	6-phosphofructokinase activity
SPRI_RS26725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPRI_RS26740	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SPRI_RS26750	COG2193	ferroxidase activity
SPRI_RS26755	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPRI_RS26765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SPRI_RS26770	COG0515	serine threonine protein kinase
SPRI_RS26770	COG2815	serine threonine protein kinase
SPRI_RS26775	COG2022	thiamine diphosphate biosynthetic process
SPRI_RS26785	COG2022	thiamine diphosphate biosynthetic process
SPRI_RS26785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_RS26805	COG0352	thiamine-phosphate diphosphorylase activity
SPRI_RS26830	COG1309	transcriptional regulator
SPRI_RS26840	COG1121	(ABC) transporter
SPRI_RS26870	COG0714	Associated with various cellular activities
SPRI_RS26880	COG0275	rRNA processing
SPRI_RS26895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPRI_RS26905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPRI_RS26910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPRI_RS26920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPRI_RS26925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPRI_RS26935	COG1496	oxidoreductase activity
SPRI_RS26940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPRI_RS26945	COG1799	cell septum assembly
SPRI_RS26955	COG3599	regulation of cell shape
SPRI_RS26960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPRI_RS26975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPRI_RS27030	COG0587	DNA-directed DNA polymerase activity
SPRI_RS27035	COG1432	Conserved Protein
SPRI_RS27075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPRI_RS27080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPRI_RS27085	COG0131	Imidazoleglycerol-phosphate dehydratase
SPRI_RS27095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SPRI_RS27100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPRI_RS27105	COG0251	oxidation-reduction process
SPRI_RS27110	COG0107	imidazoleglycerol-phosphate synthase activity
SPRI_RS27125	COG2508	Transcriptional regulator
SPRI_RS27130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_RS27140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SPRI_RS27165	COG0134	indole-3-glycerol-phosphate synthase activity
SPRI_RS27175	COG0133	tryptophan synthase activity
SPRI_RS27180	COG0159	tryptophan synthase activity
SPRI_RS27190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPRI_RS27200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_RS27205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS27225	COG1397	ADP-ribosylglycohydrolase
SPRI_RS27235	COG0067	glutamate synthase
SPRI_RS27235	COG0070	glutamate synthase
SPRI_RS27235	COG0069	glutamate synthase activity
SPRI_RS27255	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS27260	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS27265	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS27270	COG1309	transcriptional regulator
SPRI_RS27275	COG0183	Belongs to the thiolase family
SPRI_RS27280	COG1278	Cold shock
SPRI_RS27290	COG4941	Belongs to the sigma-70 factor family
SPRI_RS27295	COG3795	YCII-related domain
SPRI_RS27315	COG1024	Enoyl-CoA hydratase
SPRI_RS27325	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS27335	COG2732	(Barnase) inhibitor
SPRI_RS27365	COG1605	Chorismate mutase
SPRI_RS27365	COG0287	Prephenate dehydrogenase
SPRI_RS27385	COG0737	Belongs to the 5'-nucleotidase family
SPRI_RS27415	COG0683	leucine binding
SPRI_RS27440	COG3903	Transcriptional regulator
SPRI_RS27440	COG3629	intracellular signal transduction
SPRI_RS27470	COG1132	(ABC) transporter
SPRI_RS27475	COG2050	protein possibly involved in aromatic compounds catabolism
SPRI_RS27505	COG1643	Atp-dependent helicase
SPRI_RS27510	COG2226	methyltransferase
SPRI_RS27515	COG0539	negative regulation of cytoplasmic translation
SPRI_RS27530	COG0237	dephospho-CoA kinase activity
SPRI_RS27550	COG0330	HflC and HflK could
SPRI_RS27555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_RS27570	COG0402	S-adenosylhomocysteine deaminase activity
SPRI_RS27585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPRI_RS27610	COG2313	pseudouridylate synthase activity
SPRI_RS27630	COG0477	Major facilitator Superfamily
SPRI_RS27635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPRI_RS27640	COG0584	glycerophosphoryl diester phosphodiesterase
SPRI_RS27650	COG0556	nucleotide-excision repair
SPRI_RS27685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPRI_RS27700	COG0322	excinuclease ABC activity
SPRI_RS27705	COG1660	Displays ATPase and GTPase activities
SPRI_RS27710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPRI_RS27715	COG1481	regulation of sporulation
SPRI_RS27725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPRI_RS27730	COG0126	phosphoglycerate kinase activity
SPRI_RS27735	COG0149	triose-phosphate isomerase activity
SPRI_RS27740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPRI_RS27750	COG0166	Belongs to the GPI family
SPRI_RS27770	COG1846	Transcriptional regulator
SPRI_RS27775	COG2197	response regulator
SPRI_RS27780	COG4585	Histidine kinase
SPRI_RS27785	COG1131	(ABC) transporter
SPRI_RS27795	COG0363	glucosamine-6-phosphate deaminase activity
SPRI_RS27810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPRI_RS27820	COG0109	protoheme IX farnesyltransferase activity
SPRI_RS27865	COG0719	Fe-S assembly protein
SPRI_RS27875	COG0396	ATPase activity
SPRI_RS27880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPRI_RS27885	COG0822	iron-sulfur transferase activity
SPRI_RS27905	COG2171	N-acyltransferase activity
SPRI_RS27915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_RS27955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPRI_RS27960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_RS27980	COG0768	penicillin binding
SPRI_RS27985	COG2197	response regulator
SPRI_RS27990	COG4585	Histidine kinase
SPRI_RS28005	COG1414	Transcriptional regulator
SPRI_RS28045	COG1902	pentaerythritol trinitrate reductase activity
SPRI_RS28055	COG1917	Cupin 2, conserved barrel domain protein
SPRI_RS28070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPRI_RS28105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_RS28120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPRI_RS28125	COG0736	holo-[acyl-carrier-protein] synthase activity
SPRI_RS28135	COG1595	DNA-templated transcription, initiation
SPRI_RS28160	COG1797	cobyrinic acid a,c-diamide synthase activity
SPRI_RS28175	COG1492	cobalamin metabolic process
SPRI_RS28180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SPRI_RS28195	COG0235	Class ii aldolase
SPRI_RS28215	COG0488	(ABC) transporter
SPRI_RS28265	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_RS28280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPRI_RS28295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_RS28310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPRI_RS28315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPRI_RS28335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SPRI_RS28350	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS28365	COG2186	Transcriptional regulator
SPRI_RS28370	COG2807	transmembrane transport
SPRI_RS28385	COG3830	Belongs to the UPF0237 family
SPRI_RS28385	COG0560	Phosphoserine phosphatase
SPRI_RS28390	COG1716	ATPase activity
SPRI_RS28390	COG1131	(ABC) transporter
SPRI_RS28390	COG0842	Transport permease protein
SPRI_RS28400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPRI_RS28405	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS28410	COG4585	Histidine kinase
SPRI_RS28415	COG2197	response regulator
SPRI_RS28430	COG1119	ATPase activity
SPRI_RS28455	COG1881	PFAM PEBP family protein
SPRI_RS28465	COG2094	Belongs to the DNA glycosylase MPG family
SPRI_RS28500	COG0647	UMP catabolic process
SPRI_RS28505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS28510	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS28515	COG1120	ATPase activity
SPRI_RS28535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SPRI_RS28540	COG0497	DNA recombination
SPRI_RS28555	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_RS28560	COG0504	CTP synthase activity
SPRI_RS28565	COG0494	nUDIX hydrolase
SPRI_RS28580	COG0686	Belongs to the AlaDH PNT family
SPRI_RS28595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPRI_RS28600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPRI_RS28605	COG1187	pseudouridine synthase activity
SPRI_RS28650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPRI_RS28660	COG1160	GTP binding
SPRI_RS28700	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS28725	COG0477	Major facilitator Superfamily
SPRI_RS28730	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS28735	COG1799	cell septum assembly
SPRI_RS28765	COG0641	radical SAM
SPRI_RS28780	COG3903	Transcriptional regulator
SPRI_RS28780	COG3629	intracellular signal transduction
SPRI_RS28800	COG1309	transcriptional regulator
SPRI_RS28805	COG0477	Major facilitator Superfamily
SPRI_RS28810	COG0587	DNA-directed DNA polymerase activity
SPRI_RS28845	COG0789	Transcriptional regulator
SPRI_RS28855	COG4565	transcriptional regulatory protein
SPRI_RS28885	COG1725	Transcriptional regulator
SPRI_RS28900	COG2755	lipolytic protein G-D-S-L family
SPRI_RS28905	COG0515	serine threonine protein kinase
SPRI_RS28915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPRI_RS28945	COG2188	Transcriptional regulator
SPRI_RS28950	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SPRI_RS28955	COG1309	transcriptional regulator
SPRI_RS28960	COG0243	molybdopterin cofactor binding
SPRI_RS28965	COG2851	Citrate transporter
SPRI_RS28985	COG3842	ATPase activity
SPRI_RS29000	COG0477	Major facilitator Superfamily
SPRI_RS29010	COG0640	Transcriptional regulator
SPRI_RS29020	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS29065	COG3876	Protein conserved in bacteria
SPRI_RS29070	COG0300	oxidoreductase activity
SPRI_RS29075	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS29085	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS29110	COG2149	membrane
SPRI_RS29115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPRI_RS29140	COG3265	gluconokinase activity
SPRI_RS29145	COG2186	Transcriptional regulator
SPRI_RS29150	COG1113	amino acid transport
SPRI_RS29165	COG0564	pseudouridine synthase activity
SPRI_RS29215	COG0667	Aldo Keto reductase
SPRI_RS29220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS29235	COG0598	Magnesium transport protein CorA
SPRI_RS29255	COG0215	cysteine-tRNA ligase activity
SPRI_RS29270	COG4948	Mandelate Racemase Muconate Lactonizing
SPRI_RS29275	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS29280	COG2186	Transcriptional regulator
SPRI_RS29285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPRI_RS29290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_RS29295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPRI_RS29300	COG1414	Transcriptional regulator
SPRI_RS29310	COG1410	methionine synthase
SPRI_RS29310	COG0646	methionine synthase
SPRI_RS29320	COG0747	negative chemotaxis
SPRI_RS29325	COG2197	response regulator
SPRI_RS29335	COG1994	Peptidase M50
SPRI_RS29335	COG0517	IMP dehydrogenase activity
SPRI_RS29355	COG1222	aaa ATPase
SPRI_RS29360	COG4122	O-methyltransferase activity
SPRI_RS29370	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SPRI_RS29375	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SPRI_RS29380	COG1609	Transcriptional regulator
SPRI_RS29390	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SPRI_RS29395	COG0545	Peptidyl-prolyl cis-trans isomerase
SPRI_RS29405	COG2378	regulation of single-species biofilm formation
SPRI_RS29425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPRI_RS29430	COG0805	protein transport
SPRI_RS29470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPRI_RS29475	COG4175	Glycine betaine
SPRI_RS29475	COG0517	IMP dehydrogenase activity
SPRI_RS29505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPRI_RS29510	COG0531	amino acid
SPRI_RS29520	COG0174	glutamine synthetase
SPRI_RS29525	COG1012	belongs to the aldehyde dehydrogenase family
SPRI_RS29530	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS29565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPRI_RS29570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPRI_RS29575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPRI_RS29580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPRI_RS29585	COG5002	protein histidine kinase activity
SPRI_RS29590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPRI_RS29595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPRI_RS29595	COG0072	phenylalanine-tRNA ligase activity
SPRI_RS29615	COG1649	PFAM Uncharacterised BCR, COG1649
SPRI_RS29625	COG0697	spore germination
SPRI_RS29660	COG0697	spore germination
SPRI_RS29670	COG4106	trans-aconitate 2-methyltransferase activity
SPRI_RS29680	COG0477	Major facilitator Superfamily
SPRI_RS29690	COG0697	spore germination
SPRI_RS29710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SPRI_RS29715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SPRI_RS29720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPRI_RS29725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPRI_RS29730	COG1438	arginine binding
SPRI_RS29745	COG0137	argininosuccinate synthase activity
SPRI_RS29750	COG0165	Argininosuccinate lyase
SPRI_RS29755	COG3973	AAA domain
SPRI_RS29775	COG3629	intracellular signal transduction
SPRI_RS29775	COG3903	Transcriptional regulator
SPRI_RS29785	COG0477	Major facilitator Superfamily
SPRI_RS29790	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS29790	COG0204	Acyl-transferase
SPRI_RS29795	COG0584	glycerophosphoryl diester phosphodiesterase
SPRI_RS29820	COG2011	ABC-type metal ion transport system permease component
SPRI_RS29825	COG1464	Belongs to the NlpA lipoprotein family
SPRI_RS29840	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SPRI_RS29845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPRI_RS29845	COG1648	precorrin-2 dehydrogenase activity
SPRI_RS29905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPRI_RS29915	COG0456	acetyltransferase
SPRI_RS29965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPRI_RS29980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPRI_RS30000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPRI_RS30005	COG1560	Kdo2-lipid A biosynthetic process
SPRI_RS30010	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS30020	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SPRI_RS30025	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SPRI_RS30030	COG0217	transcriptional regulatory protein
SPRI_RS30035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SPRI_RS30040	COG0632	four-way junction helicase activity
SPRI_RS30045	COG2255	four-way junction helicase activity
SPRI_RS30055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_RS30060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPRI_RS30065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPRI_RS30070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPRI_RS30075	COG2815	serine threonine protein kinase
SPRI_RS30075	COG0515	serine threonine protein kinase
SPRI_RS30090	COG1196	nuclear chromosome segregation
SPRI_RS30105	COG0124	histidyl-tRNA synthetase
SPRI_RS30125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPRI_RS30145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPRI_RS30150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPRI_RS30160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPRI_RS30170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SPRI_RS30175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPRI_RS30180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPRI_RS30185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SPRI_RS30195	COG0006	proline dipeptidase activity
SPRI_RS30200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPRI_RS30205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPRI_RS30215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPRI_RS30220	COG0540	Belongs to the ATCase OTCase family
SPRI_RS30225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPRI_RS30235	COG0505	Belongs to the CarA family
SPRI_RS30240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPRI_RS30245	COG0167	dihydroorotate dehydrogenase activity
SPRI_RS30250	COG0284	orotidine-5'-phosphate decarboxylase activity
SPRI_RS30275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPRI_RS30290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPRI_RS30300	COG0604	alcohol dehydrogenase
SPRI_RS30310	COG2409	Drug exporters of the RND superfamily
SPRI_RS30315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPRI_RS30320	COG2390	Transcriptional regulator
SPRI_RS30330	COG1191	sigma factor activity
SPRI_RS30340	COG0531	amino acid
SPRI_RS30350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPRI_RS30365	COG2233	PERMEase
SPRI_RS30370	COG0738	Major facilitator superfamily
SPRI_RS30375	COG1846	Transcriptional regulator
SPRI_RS30375	COG1940	carbohydrate kinase activity
SPRI_RS30380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPRI_RS30405	COG3201	nicotinamide mononucleotide transporter
SPRI_RS30410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPRI_RS30410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPRI_RS30415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPRI_RS30420	COG0140	phosphoribosyl-ATP diphosphatase activity
SPRI_RS30425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPRI_RS30445	COG0464	growth
SPRI_RS30450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPRI_RS30460	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS30480	COG1216	Glycosyl transferase, family 2
SPRI_RS30485	COG3030	protein affecting phage T7 exclusion by the F plasmid
SPRI_RS30495	COG2270	Major facilitator Superfamily
SPRI_RS30540	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS30545	COG0438	transferase activity, transferring glycosyl groups
SPRI_RS30555	COG2814	Major facilitator Superfamily
SPRI_RS30585	COG2018	Roadblock/LC7 domain
SPRI_RS30600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_RS30605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPRI_RS30610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS30625	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SPRI_RS30640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPRI_RS30650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPRI_RS30685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPRI_RS30705	COG1716	ATPase activity
SPRI_RS30725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPRI_RS30735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPRI_RS30735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPRI_RS30760	COG0384	phenazine biosynthesis protein PhzF
SPRI_RS30835	COG0484	heat shock protein binding
SPRI_RS30840	COG0443	Heat shock 70 kDa protein
SPRI_RS30845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPRI_RS30870	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SPRI_RS30880	COG2072	flavoprotein involved in K transport
SPRI_RS30885	COG0640	Transcriptional regulator
SPRI_RS30890	COG0640	Transcriptional regulator
SPRI_RS30935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPRI_RS30945	COG2318	DinB family
SPRI_RS30965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPRI_RS30975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPRI_RS30980	COG2813	Specifically methylates the guanine in position
SPRI_RS30990	COG1968	undecaprenyl-diphosphatase activity
SPRI_RS31005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPRI_RS31040	COG2124	cytochrome p450
SPRI_RS31075	COG0110	maltose O-acetyltransferase activity
SPRI_RS31095	COG1832	CoA-binding protein
SPRI_RS31100	COG1739	Uncharacterized protein family UPF0029
SPRI_RS31105	COG0420	3'-5' exonuclease activity
SPRI_RS31110	COG0419	ATPase involved in DNA repair
SPRI_RS31115	COG1522	sequence-specific DNA binding
SPRI_RS31130	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS31145	COG0626	cystathionine gamma-synthase activity
SPRI_RS31170	COG1595	DNA-templated transcription, initiation
SPRI_RS31175	COG2188	Transcriptional regulator
SPRI_RS31180	COG1940	carbohydrate kinase activity
SPRI_RS31195	COG3397	chitin binding
SPRI_RS31205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPRI_RS31260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPRI_RS31265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPRI_RS31270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPRI_RS31285	COG0791	NLP P60 protein
SPRI_RS31295	COG0740	serine-type endopeptidase activity
SPRI_RS31310	COG1309	transcriptional regulator
SPRI_RS31315	COG0831	urea catabolic process
SPRI_RS31320	COG0832	Belongs to the urease beta subunit family
SPRI_RS31325	COG0804	urea catabolic process
SPRI_RS31330	COG0830	nickel cation binding
SPRI_RS31335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SPRI_RS31340	COG0829	nickel cation binding
SPRI_RS31350	COG0204	Acyl-transferase
SPRI_RS31355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPRI_RS31380	COG1957	nucleoside hydrolase
SPRI_RS31405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPRI_RS31415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPRI_RS31435	COG3458	cephalosporin-C deacetylase activity
SPRI_RS31445	COG0747	negative chemotaxis
SPRI_RS31455	COG0444	Belongs to the ABC transporter superfamily
SPRI_RS31480	COG0205	6-phosphofructokinase activity
SPRI_RS31485	COG3442	glutamine amidotransferase
SPRI_RS31495	COG0242	peptide deformylase activity
SPRI_RS31505	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS31520	COG1946	Acyl-CoA thioesterase
SPRI_RS31535	COG1132	(ABC) transporter
SPRI_RS31540	COG1132	(ABC) transporter
SPRI_RS31550	COG1132	(ABC) transporter
SPRI_RS31555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPRI_RS31560	COG2072	flavoprotein involved in K transport
SPRI_RS31580	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPRI_RS31605	COG0596	Alpha beta hydrolase
SPRI_RS31615	COG2835	tetraacyldisaccharide 4'-kinase activity
SPRI_RS31635	COG4981	capsule polysaccharide biosynthetic process
SPRI_RS31640	COG0500	methyltransferase
SPRI_RS31690	COG2706	6-phosphogluconolactonase activity
SPRI_RS31700	COG2971	BadF BadG BcrA BcrD
SPRI_RS31705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPRI_RS31720	COG1902	pentaerythritol trinitrate reductase activity
SPRI_RS31725	COG0640	Transcriptional regulator
SPRI_RS31745	COG1309	transcriptional regulator
SPRI_RS31755	COG0671	phosphoesterase, PA-phosphatase related
SPRI_RS31775	COG0584	glycerophosphoryl diester phosphodiesterase
SPRI_RS31805	COG0204	Acyl-transferase
SPRI_RS31825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SPRI_RS31835	COG0515	serine threonine protein kinase
SPRI_RS31860	COG1175	transmembrane transport
SPRI_RS31865	COG0395	ABC-type sugar transport system, permease component
SPRI_RS31880	COG1846	Transcriptional regulator
SPRI_RS31885	COG2409	Drug exporters of the RND superfamily
SPRI_RS31890	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS31925	COG1660	Displays ATPase and GTPase activities
SPRI_RS31940	COG0644	oxidoreductase
SPRI_RS31955	COG4585	Histidine kinase
SPRI_RS31960	COG2197	response regulator
SPRI_RS31980	COG2223	nitrite transmembrane transporter activity
SPRI_RS31985	COG1940	carbohydrate kinase activity
SPRI_RS32010	COG1136	(ABC) transporter
SPRI_RS32015	COG0577	efflux transmembrane transporter activity
SPRI_RS32045	COG1349	DNA-binding transcription factor activity
SPRI_RS32055	COG0464	growth
SPRI_RS32080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPRI_RS32110	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS32180	COG0488	(ABC) transporter
SPRI_RS32185	COG0488	(ABC) transporter
SPRI_RS32190	COG0302	gtp cyclohydrolase
SPRI_RS32225	COG3250	beta-galactosidase activity
SPRI_RS32230	COG1609	Transcriptional regulator
SPRI_RS32235	COG3254	rhamnose metabolic process
SPRI_RS32250	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPRI_RS32255	COG1129	ABC transporter
SPRI_RS32265	COG3347	Dehydrogenase
SPRI_RS32265	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS32270	COG1070	Carbohydrate kinase
SPRI_RS32275	COG2186	Transcriptional regulator
SPRI_RS32280	COG0247	lactate metabolic process
SPRI_RS32285	COG1139	Iron-sulfur cluster binding protein
SPRI_RS32290	COG1556	Lactate utilization protein
SPRI_RS32300	COG0187	DNA topoisomerase II activity
SPRI_RS32315	COG1621	beta-fructofuranosidase activity
SPRI_RS32340	COG1609	Transcriptional regulator
SPRI_RS32360	COG2318	DinB family
SPRI_RS32365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPRI_RS32375	COG0640	Transcriptional regulator
SPRI_RS32390	COG1595	DNA-templated transcription, initiation
SPRI_RS32410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPRI_RS32415	COG0640	Transcriptional regulator
SPRI_RS32420	COG0798	PFAM Bile acid sodium symporter
SPRI_RS32425	COG2072	flavoprotein involved in K transport
SPRI_RS32435	COG0667	Aldo Keto reductase
SPRI_RS32460	COG1063	alcohol dehydrogenase
SPRI_RS32470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_RS32475	COG1672	PFAM Archaeal ATPase
SPRI_RS32475	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SPRI_RS32485	COG0435	Glutathione S-transferase
SPRI_RS32490	COG1278	Cold shock
SPRI_RS32510	COG1454	alcohol dehydrogenase
SPRI_RS32550	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS32560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPRI_RS32560	COG0596	Alpha beta hydrolase
SPRI_RS32570	COG0346	lactoylglutathione lyase activity
SPRI_RS32580	COG2814	Major facilitator Superfamily
SPRI_RS32590	COG1846	Transcriptional regulator
SPRI_RS32620	COG0395	ABC-type sugar transport system, permease component
SPRI_RS32625	COG1175	transmembrane transport
SPRI_RS32655	COG1175	transmembrane transport
SPRI_RS32660	COG0395	ABC-type sugar transport system, permease component
SPRI_RS32680	COG0673	inositol 2-dehydrogenase activity
SPRI_RS32695	COG4214	carbohydrate transport
SPRI_RS32700	COG1129	ABC transporter
SPRI_RS32705	COG4213	ABC transporter substrate-binding protein
SPRI_RS32715	COG1414	Transcriptional regulator
SPRI_RS32720	COG3386	PFAM SMP-30 Gluconolaconase
SPRI_RS32740	COG1175	transmembrane transport
SPRI_RS32745	COG0395	ABC-type sugar transport system, permease component
SPRI_RS32750	COG3507	Belongs to the glycosyl hydrolase 43 family
SPRI_RS32775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPRI_RS32785	COG1686	Belongs to the peptidase S11 family
SPRI_RS32795	COG0659	secondary active sulfate transmembrane transporter activity
SPRI_RS32830	COG2197	response regulator
SPRI_RS32835	COG2838	Isocitrate dehydrogenase
SPRI_RS32845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPRI_RS32860	COG2205	protein histidine kinase activity
SPRI_RS32900	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SPRI_RS32900	COG5297	Belongs to the glycosyl hydrolase family 6
SPRI_RS32915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPRI_RS32920	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SPRI_RS32925	COG0655	NAD(P)H dehydrogenase (quinone) activity
SPRI_RS32930	COG0028	Belongs to the TPP enzyme family
SPRI_RS32935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SPRI_RS32950	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS32985	COG1609	Transcriptional regulator
SPRI_RS32995	COG1175	transmembrane transport
SPRI_RS33005	COG1472	Belongs to the glycosyl hydrolase 3 family
SPRI_RS33070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPRI_RS33075	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SPRI_RS33080	COG2080	2 iron, 2 sulfur cluster binding
SPRI_RS33085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPRI_RS33085	COG0723	plastoquinol--plastocyanin reductase activity
SPRI_RS33105	COG2197	response regulator
SPRI_RS33110	COG4585	Histidine kinase
SPRI_RS33115	COG0667	Aldo Keto reductase
SPRI_RS33130	COG1175	transmembrane transport
SPRI_RS33135	COG0395	ABC-type sugar transport system, permease component
SPRI_RS33200	COG1131	(ABC) transporter
SPRI_RS33200	COG0842	Transport permease protein
SPRI_RS33200	COG1716	ATPase activity
SPRI_RS33220	COG0477	Major facilitator Superfamily
SPRI_RS33225	COG3387	PFAM Glycoside hydrolase 15-related
SPRI_RS33230	COG1597	lipid kinase activity
SPRI_RS33250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPRI_RS33280	COG0477	Major facilitator Superfamily
SPRI_RS33375	COG1222	aaa ATPase
SPRI_RS33415	COG0363	glucosamine-6-phosphate deaminase activity
SPRI_RS33425	COG1595	DNA-templated transcription, initiation
SPRI_RS33475	COG1653	transport
SPRI_RS33480	COG4209	transmembrane transport
SPRI_RS33485	COG0395	ABC-type sugar transport system, permease component
SPRI_RS33540	COG2045	Belongs to the ComB family
SPRI_RS33560	COG1733	regulation of RNA biosynthetic process
SPRI_RS33570	COG2318	DinB family
SPRI_RS33610	COG2124	cytochrome p450
SPRI_RS33685	COG1295	ribonuclease BN
SPRI_RS33715	COG0640	Transcriptional regulator
SPRI_RS33730	COG4552	Acetyltransferase involved in intracellular survival and related
SPRI_RS33735	COG2936	dipeptidyl-peptidase activity
SPRI_RS33770	COG2132	Multicopper oxidase
SPRI_RS33790	COG1122	ATPase activity
SPRI_RS33800	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SPRI_RS33805	COG0310	cobalt ion transport
SPRI_RS33810	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPRI_RS33815	COG1461	Dihydroxyacetone kinase
SPRI_RS33820	COG2376	Dihydroxyacetone kinase
SPRI_RS33875	COG0739	heme binding
SPRI_RS33875	COG0741	lytic transglycosylase activity
SPRI_RS33875	COG1196	nuclear chromosome segregation
SPRI_RS33910	COG0747	negative chemotaxis
SPRI_RS33915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPRI_RS33930	COG0783	Belongs to the Dps family
SPRI_RS33935	COG0009	L-threonylcarbamoyladenylate synthase
SPRI_RS33955	COG2084	Dehydrogenase
SPRI_RS33990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_RS33995	COG0243	molybdopterin cofactor binding
SPRI_RS34010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPRI_RS34020	COG0726	polysaccharide deacetylase
SPRI_RS34025	COG1349	DNA-binding transcription factor activity
SPRI_RS34030	COG1105	Belongs to the carbohydrate kinase PfkB family
SPRI_RS34040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPRI_RS34045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPRI_RS34060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_RS34115	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_RS34140	COG2124	cytochrome p450
SPRI_RS34185	COG1191	sigma factor activity
SPRI_RS34195	COG0784	Response regulator, receiver
SPRI_RS34195	COG2205	protein histidine kinase activity
SPRI_RS34240	COG0693	protein deglycase activity
SPRI_RS34245	COG0517	IMP dehydrogenase activity
SPRI_RS34275	COG3958	Transketolase
SPRI_RS34305	COG1024	Enoyl-CoA hydratase
SPRI_RS34310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_RS34315	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS34340	COG3548	integral membrane protein
SPRI_RS34355	COG0730	response to heat
SPRI_RS34360	COG1937	Protein conserved in bacteria
SPRI_RS34365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPRI_RS34370	COG0515	serine threonine protein kinase
SPRI_RS34380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPRI_RS34390	COG0667	Aldo Keto reductase
SPRI_RS34395	COG2815	serine threonine protein kinase
SPRI_RS34395	COG0515	serine threonine protein kinase
SPRI_RS34400	COG2070	2-Nitropropane dioxygenase
SPRI_RS34410	COG2226	methyltransferase
SPRI_RS34440	COG0387	Pfam Sodium calcium exchanger
SPRI_RS34465	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS34500	COG0483	inositol monophosphate 1-phosphatase activity
SPRI_RS34510	COG1024	Enoyl-CoA hydratase
SPRI_RS34575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPRI_RS34605	COG3290	protein histidine kinase activity
SPRI_RS34630	COG1573	uracil-dna glycosylase
SPRI_RS34735	COG1309	transcriptional regulator
SPRI_RS34770	COG1191	sigma factor activity
SPRI_RS34790	COG5002	protein histidine kinase activity
SPRI_RS34790	COG2205	protein histidine kinase activity
SPRI_RS34790	COG0784	Response regulator, receiver
SPRI_RS34795	COG5001	Diguanylate cyclase
SPRI_RS34795	COG5002	protein histidine kinase activity
SPRI_RS34795	COG3447	MASE1 domain protein
SPRI_RS34900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPRI_RS34905	COG0477	Major facilitator Superfamily
SPRI_RS34915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPRI_RS34920	COG1021	2,3-dihydroxybenzoate-AMP ligase
SPRI_RS34925	COG2423	ornithine cyclodeaminase activity
SPRI_RS34930	COG2124	cytochrome p450
SPRI_RS34935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPRI_RS34935	COG0512	Glutamine amidotransferase of anthranilate synthase
SPRI_RS34940	COG0287	Prephenate dehydrogenase
SPRI_RS34945	COG1605	Chorismate mutase
SPRI_RS34950	COG2890	protein-(glutamine-N5) methyltransferase activity
SPRI_RS34960	COG0022	dehydrogenase e1 component
SPRI_RS34965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS34965	COG3321	synthase
SPRI_RS34965	COG4221	oxidoreductase activity
SPRI_RS34965	COG0300	oxidoreductase activity
SPRI_RS34970	COG3321	synthase
SPRI_RS34970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS34970	COG0300	oxidoreductase activity
SPRI_RS34970	COG4221	oxidoreductase activity
SPRI_RS34975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS34980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS34985	COG3425	synthase
SPRI_RS34995	COG1024	Enoyl-CoA hydratase
SPRI_RS35000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_RS35000	COG4221	oxidoreductase activity
SPRI_RS35000	COG3321	synthase
SPRI_RS35000	COG1028	Short-chain dehydrogenase reductase Sdr
SPRI_RS35025	COG3629	intracellular signal transduction
SPRI_RS35070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS35105	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS35125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS35140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS35150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPRI_RS35225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPRI_RS35230	COG3425	synthase
SPRI_RS35240	COG1024	Enoyl-CoA hydratase
SPRI_RS35260	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SPRI_RS35285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPRI_RS35305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_RS35315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_RS35320	COG0159	tryptophan synthase activity
SPRI_RS35325	COG0662	Cupin 2, conserved barrel domain protein
SPRI_RS35330	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS35340	COG0135	phosphoribosylanthranilate isomerase activity
SPRI_RS35350	COG0702	epimerase
SPRI_RS35355	COG1063	alcohol dehydrogenase
SPRI_RS35365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPRI_RS35380	COG2706	6-phosphogluconolactonase activity
SPRI_RS35395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPRI_RS35400	COG3265	gluconokinase activity
SPRI_RS35415	COG0702	epimerase
SPRI_RS35440	COG0318	PFAM AMP-dependent synthetase and ligase
SPRI_RS35480	COG2197	response regulator
SPRI_RS35485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPRI_RS35495	COG1024	Enoyl-CoA hydratase
SPRI_RS35515	COG3251	PFAM MbtH domain protein
SPRI_RS35545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPRI_RS35550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPRI_RS35555	COG0646	methionine synthase
SPRI_RS35555	COG1410	methionine synthase
SPRI_RS35610	COG0596	Alpha beta hydrolase
SPRI_RS35625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPRI_RS35640	COG2072	flavoprotein involved in K transport
SPRI_RS35655	COG0156	8-amino-7-oxononanoate synthase activity
SPRI_RS35660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPRI_RS35670	COG2030	dehydratase
SPRI_RS35685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPRI_RS35690	COG0662	Cupin 2, conserved barrel domain protein
SPRI_RS35695	COG1960	acyl-CoA dehydrogenase activity
SPRI_RS35700	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SPRI_RS35705	COG0134	indole-3-glycerol-phosphate synthase activity
SPRI_RS35730	COG2132	Multicopper oxidase
SPRI_RS35745	COG0110	maltose O-acetyltransferase activity
SPRI_RS35805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPRI_RS35830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPRI_RS35845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPRI_RS35865	COG0513	Belongs to the DEAD box helicase family
SPRI_RS35880	COG2223	nitrite transmembrane transporter activity
SPRI_RS35885	COG2207	Transcriptional regulator
SPRI_RS35890	COG3795	YCII-related domain
SPRI_RS35895	COG4941	Belongs to the sigma-70 factor family
SPRI_RS35975	COG1309	transcriptional regulator
SPRI_RS35990	COG1695	Transcriptional regulator
SPRI_RS36005	COG0789	Transcriptional regulator
SPRI_RS36040	COG1278	Cold shock
SPRI_RS36070	COG0395	ABC-type sugar transport system, permease component
SPRI_RS36095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPRI_RS36120	COG2318	DinB family
SPRI_RS36185	COG0305	Participates in initiation and elongation during chromosome replication
SPRI_RS36235	COG0420	3'-5' exonuclease activity
SPRI_RS36240	COG0419	ATPase involved in DNA repair
SPRI_RS36335	COG0419	ATPase involved in DNA repair
SPRI_RS36340	COG0420	3'-5' exonuclease activity