locus-tag class description H3L99_RS00065 ENOG4107RH8 nuclease SbcCD subunit D H3L99_RS00070 ENOG4105EYH Exonuclease H3L99_RS00165 ENOG4105EYH Exonuclease H3L99_RS00240 ENOG4105K7N UPF0232 protein H3L99_RS00335 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H3L99_RS00340 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H3L99_RS00350 ENOG4105E2A Dehydrogenase H3L99_RS00360 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component H3L99_RS00375 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS00395 ENOG4105VEQ Cold shock protein H3L99_RS00430 ENOG4107TXC Transcriptional regulator H3L99_RS00445 ENOG4105VUN Transcriptional regulator H3L99_RS00460 ENOG4105J7D transcriptional regulator H3L99_RS00540 ENOG4105CHP RNA polymerase H3L99_RS00545 ENOG4105GRZ Ycii-related protein H3L99_RS00550 ENOG4105R1U AraC Family Transcriptional Regulator H3L99_RS00555 ENOG4105EU0 Major facilitator Superfamily H3L99_RS00570 ENOG4105C1J atp-dependent rna helicase H3L99_RS00595 ENOG4105BZ9 Cytochrome C oxidase, subunit I H3L99_RS00610 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H3L99_RS00695 ENOG4105EQK -acetyltransferase H3L99_RS00710 ENOG4107STQ Multicopper oxidase H3L99_RS00715 ENOG4105C3J Cysteine desulfurase H3L99_RS00735 ENOG4105DK0 Indole-3-glycerol phosphate synthase H3L99_RS00745 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS00750 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) H3L99_RS00755 ENOG4108I0Q anthranilate phosphoribosyltransferase H3L99_RS00770 ENOG410900P UPF0336 protein H3L99_RS00775 ENOG4105D7V transposase H3L99_RS00785 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H3L99_RS00795 ENOG4105CHR reductase H3L99_RS00800 ENOG4105F95 Monooxygenase H3L99_RS00815 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H3L99_RS00830 ENOG4105F2Z 3-oxoadipate enol-lactonase H3L99_RS00885 ENOG4105C3R Methionine synthase H3L99_RS00890 ENOG4107T4Z adenosine kinase H3L99_RS00895 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H3L99_RS00905 ENOG4105D7V transposase H3L99_RS00925 ENOG4105WQT MbtH domain protein H3L99_RS00955 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS00960 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS01000 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS01040 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H3L99_RS01060 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) H3L99_RS01075 ENOG4107YBY Hydrolase H3L99_RS01085 ENOG4105CPQ Dehydrogenase H3L99_RS01100 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase H3L99_RS01110 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS01115 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) H3L99_RS01120 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H3L99_RS01135 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS01180 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H3L99_RS01205 ENOG4108KQ6 Enoyl-CoA hydratase H3L99_RS01215 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase H3L99_RS01220 ENOG41062T2 Acyl carrier protein H3L99_RS01230 ENOG4107EEY synthase H3L99_RS01275 ENOG4107V9E glucose-1-phosphate thymidylyltransferase H3L99_RS01295 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone H3L99_RS01305 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H3L99_RS01320 ENOG4105CZS beta-ketoacyl synthase H3L99_RS01335 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) H3L99_RS01340 ENOG4108KC1 acyl-Coa dehydrogenase H3L99_RS01375 ENOG4105CZS beta-ketoacyl synthase H3L99_RS01380 ENOG4105D7V transposase H3L99_RS01425 ENOG4105MXW flavin reductase domain protein, FMN-binding H3L99_RS01435 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H3L99_RS01445 ENOG4105C0W non-ribosomal peptide synthetase H3L99_RS01450 ENOG4108KQ6 Enoyl-CoA hydratase H3L99_RS01460 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase H3L99_RS01465 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase H3L99_RS01470 ENOG41062T2 Acyl carrier protein H3L99_RS01475 ENOG4107SQU synthase H3L99_RS01485 ENOG4105C0W non-ribosomal peptide synthetase H3L99_RS01540 ENOG4105CPP Dehydrogenase, E1 component H3L99_RS01550 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H3L99_RS01570 ENOG4106A3M Cytochrome p-450 H3L99_RS01580 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H3L99_RS01585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H3L99_RS01595 ENOG4105C57 major facilitator superfamily H3L99_RS01600 ENOG4105D8K carboxyl transferase H3L99_RS01615 ENOG41064MX Tetr family transcriptional regulator H3L99_RS01635 ENOG41064MX Tetr family transcriptional regulator H3L99_RS01715 ENOG4105BZU Histidine kinase H3L99_RS01720 ENOG4105BZU Histidine kinase H3L99_RS01740 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS01750 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H3L99_RS01770 ENOG4108SGK Tetr family transcriptional regulator H3L99_RS01830 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth H3L99_RS01855 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) H3L99_RS01875 ENOG4108UN4 phage SPO1 DNA polymerase-related protein H3L99_RS01960 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein H3L99_RS01995 ENOG4105E39 Enoyl-CoA hydratase H3L99_RS02005 ENOG4108MWI inositol mono-phosphatase H3L99_RS02040 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS02095 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) H3L99_RS02110 ENOG4105D9P serine threonine protein kinase H3L99_RS02115 ENOG4105CPC Aldo Keto reductase H3L99_RS02130 ENOG4108A04 Beta-lactamase H3L99_RS02145 ENOG4108V62 Rhodanese domain protein H3L99_RS02150 ENOG4105VPX protein, conserved in bacteria H3L99_RS02155 ENOG4108VCT Sulfite exporter TauE/SafE H3L99_RS02175 ENOG4105W5Z H3L99_RS02190 ENOG4105X7H acyl-CoA dehydrogenase H3L99_RS02200 ENOG4105E39 Enoyl-CoA hydratase H3L99_RS02225 ENOG4105DQE DNA ligase H3L99_RS02230 ENOG4108IUS Transketolase H3L99_RS02260 ENOG41080XP Cbs domain H3L99_RS02265 ENOG4108Z0Z intracellular protease Pfpi family H3L99_RS02320 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS02365 ENOG4107E6A Cytochrome p-450 H3L99_RS02390 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H3L99_RS02400 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 H3L99_RS02445 ENOG4107UVD Beta-phosphoglucomutase family hydrolase H3L99_RS02460 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H3L99_RS02465 ENOG410849S phosphocarrier protein (HPr) H3L99_RS02470 ENOG4105DM4 PTS System H3L99_RS02475 ENOG4105DE4 1-phosphofructokinase H3L99_RS02480 ENOG410804X Transcriptional regulator H3L99_RS02485 ENOG4108ZJ4 polysaccharide deacetylase H3L99_RS02500 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H3L99_RS02515 ENOG4105BZ9 Cytochrome C oxidase, subunit I H3L99_RS02550 ENOG4106KE4 Dehydrogenase H3L99_RS02570 ENOG4107RTD sua5 ycio yrdc ywlc family protein H3L99_RS02575 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction H3L99_RS02590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS02635 ENOG4105E4C Lytic transglycosylase catalytic H3L99_RS02690 ENOG4105CMT Dihydroxyacetone kinase H3L99_RS02695 ENOG4108UTZ Dihydroxyacetone kinase H3L99_RS02700 ENOG4105VDH Dihydroxyacetone kinase H3L99_RS02705 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) H3L99_RS02720 ENOG4108JJB ABC transporter H3L99_RS02740 ENOG4107R16 Multicopper oxidase H3L99_RS02775 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) H3L99_RS02780 ENOG4105HHS UPF0256 protein H3L99_RS02790 ENOG4105C59 p-type ATPase H3L99_RS02795 ENOG41066UM arsR family transcriptional regulator H3L99_RS02825 ENOG4107U9T Pfam:Ribonuclease_BN H3L99_RS02870 ENOG4105C57 major facilitator superfamily H3L99_RS02905 ENOG4105JZI cytochrome P450 H3L99_RS02955 ENOG4105KVH Transcriptional regulator H3L99_RS02970 ENOG4108N5B 2-phosphosulfolactate phosphatase H3L99_RS03025 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component H3L99_RS03035 ENOG4107T3P ABC, transporter H3L99_RS03040 ENOG4107QK4 glycoside hydrolase, family 3 domain protein H3L99_RS03045 ENOG4105XYF acetyltransferase H3L99_RS03090 ENOG4108KPJ rna polymerase sigma factor H3L99_RS03100 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) H3L99_RS03140 ENOG4105D7D AAA ATPase H3L99_RS03245 ENOG41086KC Transcriptional regulator H3L99_RS03265 ENOG4105EYW Ion transport protein H3L99_RS03290 ENOG4105BZP glycoside hydrolase 15-related H3L99_RS03315 ENOG4105IDI abc transporter atp-binding protein H3L99_RS03380 ENOG4105DRS transport system, permease H3L99_RS03400 ENOG4105CPC Aldo Keto reductase H3L99_RS03405 ENOG4105BZU Histidine kinase H3L99_RS03410 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS03445 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit H3L99_RS03450 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding H3L99_RS03455 ENOG4105C7W Xanthine dehydrogenase H3L99_RS03480 ENOG4108JJA ABC, transporter H3L99_RS03485 ENOG4108JJA ABC, transporter H3L99_RS03530 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component H3L99_RS03540 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS03545 ENOG4105EQN UPF0261 protein H3L99_RS03575 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H3L99_RS03595 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) H3L99_RS03615 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H3L99_RS03630 ENOG4108K2F hydrolase Family 5 H3L99_RS03635 ENOG4105KNA -acetyltransferase H3L99_RS03655 ENOG4106T9R serine protease H3L99_RS03680 ENOG4107R72 Ceramidase H3L99_RS03695 ENOG4105E9K Isocitrate dehydrogenase H3L99_RS03705 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS03710 ENOG4105BZU Histidine kinase H3L99_RS03740 ENOG4105CHH sulfate transporter H3L99_RS03750 ENOG4105DZ1 carboxypeptidase H3L99_RS03760 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H3L99_RS03770 ENOG4105CXK mandelate racemase muconate lactonizing H3L99_RS03785 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase H3L99_RS03790 ENOG4105DRS transport system, permease H3L99_RS03795 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component H3L99_RS03815 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein H3L99_RS03820 ENOG4105J4Q Transcriptional regulator H3L99_RS03830 ENOG4105DFW ABC transporter H3L99_RS03835 ENOG4105C2J ABC transporter H3L99_RS03840 ENOG4108HWW ABC transporter H3L99_RS03845 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H3L99_RS03855 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) H3L99_RS03865 ENOG4105EKC H3L99_RS03875 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component H3L99_RS03880 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component H3L99_RS03920 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS03955 ENOG4105D2S major facilitator superfamily H3L99_RS03965 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase H3L99_RS03975 ENOG4105DWV Homoserine O-trans-acetylase H3L99_RS03985 ENOG4105CHR reductase H3L99_RS03995 ENOG4105C7K acetolactate synthase H3L99_RS04025 ENOG4107RQ0 Maleylacetate reductase H3L99_RS04050 ENOG4105VEQ Cold shock protein H3L99_RS04055 ENOG4105CHF Glutathione S-transferase H3L99_RS04065 ENOG4107SM8 Adenylate Guanylate cyclase H3L99_RS04070 ENOG4108X7A Terpene synthase metal-binding domain-containing protein H3L99_RS04080 ENOG4105E2A Dehydrogenase H3L99_RS04105 ENOG4105CPC Aldo Keto reductase H3L99_RS04115 ENOG4105H3G oxidoreductase H3L99_RS04125 ENOG4107YCR Transcriptional regulator, ARSR family H3L99_RS04155 ENOG4108KPJ rna polymerase sigma factor H3L99_RS04170 ENOG4105NPE arsR family transcriptional regulator H3L99_RS04205 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS04210 ENOG4105C2J ABC transporter H3L99_RS04215 ENOG4105CNN ABC, transporter H3L99_RS04220 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator H3L99_RS04230 ENOG4108HKT sucrose-6-phosphate hydrolase H3L99_RS04245 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H3L99_RS04255 ENOG41080R8 Conserved Protein H3L99_RS04260 ENOG4107QR9 Iron-sulfur cluster binding protein H3L99_RS04265 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H3L99_RS04270 ENOG4105C6F GntR Family Transcriptional Regulator H3L99_RS04275 ENOG4105DET Rhamnulokinase H3L99_RS04290 ENOG4105C2J ABC transporter H3L99_RS04295 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane H3L99_RS04315 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS04355 ENOG4105EUJ GTP cyclohydrolase i H3L99_RS04460 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H3L99_RS04485 ENOG4106F1P AAA ATPase, central domain protein H3L99_RS04495 ENOG4105MVE transcriptional regulator H3L99_RS04525 ENOG4107R34 abc transporter permease protein H3L99_RS04530 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS04555 ENOG4105DKQ ROK family H3L99_RS04560 ENOG4106UW1 Major Facilitator superfamily H3L99_RS04580 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS04585 ENOG4105BZU Histidine kinase H3L99_RS04600 ENOG4107QZT geranylgeranyl reductase H3L99_RS04605 ENOG4107PP3 Acetylornithine deacetylase H3L99_RS04615 ENOG4105I1F Resistance protein H3L99_RS04645 ENOG4105CVP deoxyribo-dipyrimidine photolyase H3L99_RS04650 ENOG4105CHR reductase H3L99_RS04700 ENOG41060NJ transcriptional regulator H3L99_RS04705 ENOG4107TPY serine threonine protein kinase H3L99_RS04715 ENOG4105C10 Electron transfer flavoprotein H3L99_RS04735 ENOG4105PSQ Acyl-transferase H3L99_RS04765 ENOG4108QXE glycerophosphoryl diester phosphodiesterase H3L99_RS04785 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H3L99_RS04815 ENOG4105YVS arsR family transcriptional regulator H3L99_RS04820 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H3L99_RS04835 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H3L99_RS04840 ENOG4105RD7 BadF BadG BcrA BcrD H3L99_RS04850 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) H3L99_RS04905 ENOG4108M6P methyltransferase H3L99_RS04910 ENOG41073B4 coagulation factor 5 8 type domain-containing protein H3L99_RS04930 ENOG4105W49 UPF0434 protein H3L99_RS04940 ENOG4107R6F Alpha Beta Hydrolase Fold protein H3L99_RS04965 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) H3L99_RS04985 ENOG4105CT3 Monooxygenase H3L99_RS04990 ENOG4105HHA aminodeoxychorismate lyase H3L99_RS04995 ENOG4105BZ1 (ABC) transporter H3L99_RS05005 ENOG4105BZ1 (ABC) transporter H3L99_RS05010 ENOG4105BZ1 (ABC) transporter H3L99_RS05025 ENOG4105C29 acyl-CoA thioesterase H3L99_RS05040 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS05050 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H3L99_RS05060 ENOG4105F1K Glutamine amidotransferase H3L99_RS05065 ENOG4105CTQ phosphohexokinase H3L99_RS05095 ENOG4105C3U ABC transporter H3L99_RS05105 ENOG4105DEF Extracellular solute-binding protein, family 5 H3L99_RS05135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H3L99_RS05140 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) H3L99_RS05145 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) H3L99_RS05150 ENOG4105JHE Major Facilitator Superfamily H3L99_RS05170 ENOG4105DU0 nucleoside hydrolase H3L99_RS05190 ENOG4105EUB pirin domain protein H3L99_RS05195 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H3L99_RS05200 ENOG4105F6E Acyl-transferase H3L99_RS05215 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) H3L99_RS05225 ENOG4105CQM Urea amidohydrolase subunit alpha H3L99_RS05230 ENOG4105KI2 Urea amidohydrolase subunit beta H3L99_RS05235 ENOG4108YZ9 Urea amidohydrolase subunit gamma H3L99_RS05240 ENOG4108Q5F Tetr family transcriptional regulator H3L99_RS05265 ENOG4107SN7 NLP P60 protein H3L99_RS05280 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) H3L99_RS05285 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H3L99_RS05290 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H3L99_RS05345 ENOG4105C83 adenylosuccinate lyase H3L99_RS05350 ENOG4108VCA G U mismatch-specific DNA glycosylase H3L99_RS05355 ENOG4108M1A Chitin-binding protein H3L99_RS05360 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) H3L99_RS05370 ENOG4105DKQ ROK family H3L99_RS05375 ENOG4105FDP GntR family transcriptional regulator H3L99_RS05380 ENOG4108KPJ rna polymerase sigma factor H3L99_RS05385 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 H3L99_RS05420 ENOG4108PSK reductase H3L99_RS05440 ENOG4105EYH Exonuclease H3L99_RS05450 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H3L99_RS05455 ENOG4105K4P CoA-binding domain protein H3L99_RS05510 ENOG4106A3M Cytochrome p-450 H3L99_RS05515 ENOG4108Z0R Transferase H3L99_RS05545 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H3L99_RS05560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) H3L99_RS05570 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) H3L99_RS05575 ENOG4107RT4 flavin reductase domain protein H3L99_RS05585 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H3L99_RS05590 ENOG4105EP9 oxidoreductase H3L99_RS05615 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H3L99_RS05625 ENOG4105CHR reductase H3L99_RS05665 ENOG41082YX Transcriptional regulator, arsr family H3L99_RS05670 ENOG41080HT Transcriptional regulator, arsr family H3L99_RS05675 ENOG4105H3G oxidoreductase H3L99_RS05685 ENOG4105FDF Could be involved in DNA repair (By similarity) H3L99_RS05715 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H3L99_RS05720 ENOG4105CFG Acts as a chaperone (By similarity) H3L99_RS05725 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H3L99_RS05765 ENOG4105CSW GntR family transcriptional regulator H3L99_RS05800 ENOG4107TIF Phenazine biosynthesis protein, PhzF family H3L99_RS05830 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor H3L99_RS05860 ENOG4108UW8 fha domain-containing protein H3L99_RS05910 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H3L99_RS05935 ENOG4108UQS dipeptidase H3L99_RS05950 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H3L99_RS05955 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H3L99_RS05960 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H3L99_RS05975 ENOG4105GWZ Roadblock lc7 family protein H3L99_RS06015 ENOG4108MJN Glycosyl Transferase H3L99_RS06030 ENOG4105JXB ankyrin repeat-containing protein H3L99_RS06065 ENOG4105DEU major facilitator superfamily H3L99_RS06070 ENOG4105Q70 H3L99_RS06075 ENOG4105FS0 cytoplasmic membrane protein H3L99_RS06080 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) H3L99_RS06090 ENOG4105EW9 transcriptional regulator AsnC family H3L99_RS06100 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS06115 ENOG4108NDC ATP-binding protein yghS H3L99_RS06120 ENOG4106F1P AAA ATPase, central domain protein H3L99_RS06140 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H3L99_RS06145 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase H3L99_RS06150 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H3L99_RS06155 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H3L99_RS06225 ENOG4105CUB amino acid H3L99_RS06235 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS06245 ENOG4105DKT Transcriptional regulator H3L99_RS06250 ENOG4105DJV ribulose-phosphate 3-epimerase H3L99_RS06255 ENOG4105EYF MMPL domain protein H3L99_RS06265 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H3L99_RS06275 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H3L99_RS06290 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H3L99_RS06315 ENOG4105SKN orotidine 5''-phosphate decarboxylase H3L99_RS06320 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) H3L99_RS06325 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H3L99_RS06330 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H3L99_RS06340 ENOG4105CD3 dihydroorotase H3L99_RS06345 ENOG4105CXT aspartate transcarbamylase H3L99_RS06350 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) H3L99_RS06360 ENOG410803B Involved in the transcription termination process (By similarity) H3L99_RS06365 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H3L99_RS06370 ENOG4105DC7 peptidase M24 H3L99_RS06380 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) H3L99_RS06385 ENOG4105D49 3-dehydroquinate synthase H3L99_RS06390 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H3L99_RS06395 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H3L99_RS06405 ENOG4105E2X shikimate dehydrogenase H3L99_RS06415 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H3L99_RS06420 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H3L99_RS06440 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H3L99_RS06460 ENOG4105CUT histidyl-tRNA synthetase H3L99_RS06475 ENOG4105C99 atpase involved in dna repair H3L99_RS06490 ENOG4105D9P serine threonine protein kinase H3L99_RS06495 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H3L99_RS06500 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) H3L99_RS06505 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H3L99_RS06510 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H3L99_RS06520 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H3L99_RS06525 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H3L99_RS06530 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) H3L99_RS06535 ENOG4105CDY transcriptional regulatory protein H3L99_RS06540 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) H3L99_RS06545 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) H3L99_RS06555 ENOG4105E2K Glycosyl transferase (Group 1 H3L99_RS06560 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase H3L99_RS06585 ENOG4105C22 threonyL-tRNA synthetase H3L99_RS06600 ENOG4108JDX DNA polymerase iii, epsilon subunit H3L99_RS06630 ENOG4105KF0 sporulation and cell division protein, SsgA H3L99_RS06655 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) H3L99_RS06665 ENOG4105CRQ synthase (Component I) H3L99_RS06730 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) H3L99_RS06745 ENOG4105D01 (LipO)protein H3L99_RS06750 ENOG4108UMI ABC transporter, permease H3L99_RS06755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H3L99_RS06780 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H3L99_RS06785 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS06790 ENOG4105C57 major facilitator superfamily H3L99_RS06795 ENOG4105RJZ Transcriptional regulator H3L99_RS06815 ENOG4105EEM helicase H3L99_RS06820 ENOG4105CH7 arginosuccinase H3L99_RS06825 ENOG4105CDH Citrulline--aspartate ligase H3L99_RS06840 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) H3L99_RS06845 ENOG4105C8Y Acetylornithine aminotransferase H3L99_RS06850 ENOG4105CAS nag kinase H3L99_RS06860 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H3L99_RS06880 ENOG4108RNG Permease of the drug metabolite transporter H3L99_RS06890 ENOG4105C57 major facilitator superfamily H3L99_RS06900 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) H3L99_RS06910 ENOG4108KTG Membrane protein, drug metabolite transporter H3L99_RS06950 ENOG4105T38 integral membrane protein H3L99_RS06960 ENOG4105F32 YngK protein H3L99_RS06985 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H3L99_RS06990 ENOG4105BZU Histidine kinase H3L99_RS06995 ENOG4108RWN rrna methyltransferase H3L99_RS07000 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) H3L99_RS07005 ENOG41084BS 50S ribosomal protein L35 H3L99_RS07010 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H3L99_RS07045 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H3L99_RS07050 ENOG4105C26 Dehydrogenase H3L99_RS07055 ENOG4105C5F glutamine synthetase H3L99_RS07065 ENOG4105CUB amino acid H3L99_RS07070 ENOG4108Z86 Glutamine amidotransferase H3L99_RS07100 ENOG4108IJ7 Glycine betaine H3L99_RS07105 ENOG4105HFS 5'-3' exonuclease H3L99_RS07145 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H3L99_RS07150 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H3L99_RS07170 ENOG4108FFZ Transcriptional regulator H3L99_RS07180 ENOG4108V1T peptidylprolyl cis-trans isomerase H3L99_RS07185 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) H3L99_RS07195 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS07200 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) H3L99_RS07205 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) H3L99_RS07210 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) H3L99_RS07215 ENOG4105E5F proteasome H3L99_RS07220 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) H3L99_RS07250 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS07255 ENOG4105DEF Extracellular solute-binding protein, family 5 H3L99_RS07265 ENOG4105C3R Methionine synthase H3L99_RS07270 ENOG4108K8U Glycerol operon regulatory protein H3L99_RS07275 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H3L99_RS07280 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H3L99_RS07285 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H3L99_RS07290 ENOG4105JXH GntR family transcriptional regulator H3L99_RS07300 ENOG4105DIA mandelate racemase muconate lactonizing H3L99_RS07315 ENOG4105C8N cysteinyl-tRNA synthetase H3L99_RS07335 ENOG4105D7N magnesium and cobalt transport protein CorA H3L99_RS07350 ENOG4105DYW oxidoreductase H3L99_RS07355 ENOG4105CPC Aldo Keto reductase H3L99_RS07385 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H3L99_RS07395 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H3L99_RS07415 ENOG4105D3G Pseudouridine synthase H3L99_RS07435 ENOG4105C6F GntR Family Transcriptional Regulator H3L99_RS07440 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H3L99_RS07445 ENOG4105C6Z Gluconate H3L99_RS07465 ENOG4105PTV Nudix Hydrolase H3L99_RS07470 ENOG4105VG5 Membrane H3L99_RS07495 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS07500 ENOG4108IG5 Transcriptional regulator H3L99_RS07505 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS07515 ENOG4105EHZ conserved protein UCP016719 H3L99_RS07545 ENOG4108Z4X TRANSCRIPTIONal H3L99_RS07560 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS07570 ENOG4108ZHR arsR family transcriptional regulator H3L99_RS07580 ENOG4105CSH Transporter H3L99_RS07595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H3L99_RS07615 ENOG4105D4T Citrate transporter H3L99_RS07620 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H3L99_RS07625 ENOG4108SGK Tetr family transcriptional regulator H3L99_RS07630 ENOG4105F1J Homogentisate 1,2-dioxygenase H3L99_RS07675 ENOG4107TPY serine threonine protein kinase H3L99_RS07680 ENOG4108TCJ secreted hydrolase H3L99_RS07695 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family H3L99_RS07725 ENOG4106YYS transcriptional regulatory protein H3L99_RS07735 ENOG4108Z6Z Transcriptional regulator H3L99_RS07760 ENOG4107IFA Lipase (EC 3.1.1.3) H3L99_RS07770 ENOG4105C0B DNA polymerase III (alpha subunit) H3L99_RS07780 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H3L99_RS07835 ENOG4106NMR serine protease H3L99_RS07840 ENOG4106NMR serine protease H3L99_RS07850 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) H3L99_RS07855 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS07860 ENOG4105C57 major facilitator superfamily H3L99_RS07885 ENOG4108I69 Glycosyl transferases group 1 H3L99_RS07910 ENOG4108IV0 ABC, transporter H3L99_RS07925 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H3L99_RS07935 ENOG4105CAT Cytidine monophosphate kinase H3L99_RS07980 ENOG4105FE9 pseudouridine synthase H3L99_RS07985 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) H3L99_RS07990 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) H3L99_RS08005 ENOG4105DCF alanine dehydrogenase H3L99_RS08015 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H3L99_RS08020 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H3L99_RS08025 ENOG4105BZP glycoside hydrolase 15-related H3L99_RS08040 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H3L99_RS08045 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H3L99_RS08065 ENOG4105E0A ABC, transporter H3L99_RS08070 ENOG4105TVJ transport system, permease H3L99_RS08075 ENOG4105DQ5 transport system permease protein H3L99_RS08080 ENOG4105DSU hydrolase H3L99_RS08115 ENOG4108VX5 3-methyladenine DNA glycosylase H3L99_RS08125 ENOG4108V1U phospholipid-binding protein H3L99_RS08150 ENOG4105DKW ABC transporter H3L99_RS08165 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS08170 ENOG4108XG2 Histidine kinase H3L99_RS08175 ENOG4105CAN Short-chain dehydrogenase reductase Sdr H3L99_RS08180 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H3L99_RS08190 ENOG4105IDI abc transporter atp-binding protein H3L99_RS08195 ENOG4105EAC phosphoserine phosphatase H3L99_RS08210 ENOG4105DJ2 Major Facilitator Superfamily H3L99_RS08215 ENOG4107YCY Transcriptional regulator H3L99_RS08230 ENOG4105CHR reductase H3L99_RS08245 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H3L99_RS08265 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H3L99_RS08270 ENOG4107QN1 sodium solute H3L99_RS08285 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F H3L99_RS08300 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H3L99_RS08315 ENOG4105BZP glycoside hydrolase 15-related H3L99_RS08345 ENOG4105VBF alkaline shock protein H3L99_RS08365 ENOG4105C5H ABC transporter H3L99_RS08385 ENOG4107W7X Aldolase H3L99_RS08400 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) H3L99_RS08405 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H3L99_RS08420 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H3L99_RS08445 ENOG4105K6V RNA polymerase H3L99_RS08450 ENOG4105RNG membrane H3L99_RS08455 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) H3L99_RS08515 ENOG4105C5R Aminotransferase H3L99_RS08540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H3L99_RS08580 ENOG4107HP6 Transcriptional regulator H3L99_RS08595 ENOG4105BZU Histidine kinase H3L99_RS08600 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS08605 ENOG4105CJN penicillin-binding protein H3L99_RS08630 ENOG4105E9Z Nad-dependent epimerase dehydratase H3L99_RS08670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H3L99_RS08680 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) H3L99_RS08700 ENOG4108UNV SUF system FeS assembly protein, NifU family H3L99_RS08705 ENOG4105C9B Cysteine desulfurase H3L99_RS08710 ENOG4105C3K feS assembly ATPase SufC H3L99_RS08720 ENOG4105JRK feS assembly protein SufD H3L99_RS08765 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H3L99_RS08775 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H3L99_RS08790 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) H3L99_RS08800 ENOG4105CJ1 ABC, transporter H3L99_RS08805 ENOG4105BZU Histidine kinase H3L99_RS08810 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS08815 ENOG41067TZ transcriptional regulator, MarR family H3L99_RS08835 ENOG4107QP8 phosphohexose isomerase H3L99_RS08855 ENOG4105BZA Phosphoglycerate kinase H3L99_RS08860 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H3L99_RS08870 ENOG4105CIE May be required for sporulation (By similarity) H3L99_RS08875 ENOG4105CHW UPF0052 protein H3L99_RS08880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H3L99_RS08885 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) H3L99_RS08900 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H3L99_RS08935 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H3L99_RS08940 ENOG4105BZU Histidine kinase H3L99_RS08945 ENOG4108QXE glycerophosphoryl diester phosphodiesterase H3L99_RS08950 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H3L99_RS08955 ENOG4105DXI Major Facilitator superfamily H3L99_RS08975 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) H3L99_RS09000 ENOG4105C5I Dehydrogenase H3L99_RS09015 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) H3L99_RS09030 ENOG4105C0D helicase H3L99_RS09055 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H3L99_RS09070 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H3L99_RS09075 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H3L99_RS09080 ENOG4105CQ7 ATP-dependent helicase H3L99_RS09115 ENOG4105KA0 thioesterase Superfamily protein H3L99_RS09120 ENOG4105BZ1 (ABC) transporter H3L99_RS09145 ENOG4108ZX0 Signal peptidase I H3L99_RS09155 ENOG4108IV0 ABC, transporter H3L99_RS09160 ENOG4105C0Z ABC transporter H3L99_RS09165 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H3L99_RS09170 ENOG4105C32 Amino acid ABC transporter (Permease) H3L99_RS09175 ENOG4105CP9 extracellular ligand-binding receptor H3L99_RS09205 ENOG4105CGH 5'-nucleotidase H3L99_RS09225 ENOG4105EHE chorismate mutase- prephenate dehydrogenase H3L99_RS09230 ENOG41063TF transcriptional regulator (AraC H3L99_RS09240 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap H3L99_RS09265 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr H3L99_RS09275 ENOG4105E39 Enoyl-CoA hydratase H3L99_RS09290 ENOG4105EA8 2-Nitropropane dioxygenase H3L99_RS09295 ENOG4105GRZ Ycii-related protein H3L99_RS09300 ENOG4105CHP RNA polymerase H3L99_RS09310 ENOG4105VEQ Cold shock protein H3L99_RS09315 ENOG4105F2C Acetyl-CoA acetyltransferase H3L99_RS09320 ENOG4108RZE Tetr family transcriptional regulator H3L99_RS09325 ENOG4105CHR reductase H3L99_RS09330 ENOG4105CC9 acyl-Coa dehydrogenase H3L99_RS09335 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS09365 ENOG41065RQ ADP-ribosylation crystallin J1 H3L99_RS09385 ENOG4108RVA ribokinase H3L99_RS09390 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H3L99_RS09400 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) H3L99_RS09410 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H3L99_RS09415 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H3L99_RS09425 ENOG4105DK0 Indole-3-glycerol phosphate synthase H3L99_RS09450 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H3L99_RS09460 ENOG4107QN1 sodium solute H3L99_RS09465 ENOG4105G9B Transcriptional regulator H3L99_RS09480 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H3L99_RS09485 ENOG4108176 endoribonuclease L-psp H3L99_RS09490 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H3L99_RS09495 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H3L99_RS09505 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H3L99_RS09510 ENOG4105CIH Imidazole acetol-phosphate transaminase H3L99_RS09515 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H3L99_RS09535 ENOG4108Z66 YbaK ebsC protein H3L99_RS09565 ENOG4105C0B DNA polymerase III (alpha subunit) H3L99_RS09620 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) H3L99_RS09630 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H3L99_RS09635 ENOG4107VQS DivIVA family H3L99_RS09645 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) H3L99_RS09650 ENOG4105DFA alanine racemase domain protein H3L99_RS09655 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H3L99_RS09660 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H3L99_RS09670 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H3L99_RS09685 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H3L99_RS09695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H3L99_RS09700 ENOG4105CJN penicillin-binding protein H3L99_RS09710 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H3L99_RS09720 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H3L99_RS09750 ENOG4105FDK ABC transporter H3L99_RS09760 ENOG4107Z3H Transcriptional regulator, TetR family H3L99_RS09770 ENOG4105EWK phytoene H3L99_RS09785 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H3L99_RS09815 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) H3L99_RS09825 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) H3L99_RS09840 ENOG4108UQY Iron-storage protein H3L99_RS09850 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase H3L99_RS09870 ENOG4105C5I Dehydrogenase H3L99_RS09875 ENOG4105CTQ phosphohexokinase H3L99_RS09880 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS09885 ENOG4105ENE Histidine kinase H3L99_RS09910 ENOG4105DKQ ROK family H3L99_RS09920 ENOG4105D0U Arsenite-activated ATPase (ArsA) H3L99_RS09940 ENOG4105JNK Glycosyl transferase (Group 1 H3L99_RS09990 ENOG4106F60 Histidine kinase H3L99_RS09995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H3L99_RS10005 ENOG4105BZW Glycerate kinase H3L99_RS10010 ENOG4105C9B Cysteine desulfurase H3L99_RS10015 ENOG4108I0Q anthranilate phosphoribosyltransferase H3L99_RS10020 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) H3L99_RS10025 ENOG4107EUI c reductase, iron-sulfur H3L99_RS10030 ENOG4107UDY cytochrome C H3L99_RS10035 ENOG4105CCU oxidase (Subunit III) H3L99_RS10045 ENOG4107UBC ErfK ybiS ycfS ynhG family protein H3L99_RS10050 ENOG4105MCD Part of cytochrome c oxidase, its function is H3L99_RS10055 ENOG4105BZ9 Cytochrome C oxidase, subunit I H3L99_RS10060 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) H3L99_RS10070 ENOG4107T4Z adenosine kinase H3L99_RS10090 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) H3L99_RS10100 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS10125 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) H3L99_RS10130 ENOG4105C0H protease H3L99_RS10140 ENOG4108YZT Adenosylcobinamide kinase H3L99_RS10145 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) H3L99_RS10155 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) H3L99_RS10170 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H3L99_RS10190 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H3L99_RS10205 ENOG4105CHR reductase H3L99_RS10235 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) H3L99_RS10240 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H3L99_RS10275 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H3L99_RS10280 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) H3L99_RS10305 ENOG4108222 arsenate reductase H3L99_RS10310 ENOG4106SPC secreted protein H3L99_RS10320 ENOG4107R5B glutamine synthetase H3L99_RS10325 ENOG4107NHD transcriptional regulator H3L99_RS10350 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS10370 ENOG4105M2Z protein tyrosine serine phosphatase H3L99_RS10390 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS10400 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) H3L99_RS10410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H3L99_RS10430 ENOG4105C5F glutamine synthetase H3L99_RS10445 ENOG4105EYF MMPL domain protein H3L99_RS10470 ENOG4105C4K Nad synthetase H3L99_RS10485 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H3L99_RS10525 ENOG4107XZ0 Peptidase M50 H3L99_RS10575 ENOG4106A0S H3L99_RS10595 ENOG4105C2C drug resistance transporter, Bcr CflA H3L99_RS10605 ENOG4105DGI Alkaline phosphatase H3L99_RS10610 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H3L99_RS10685 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) H3L99_RS10690 ENOG4105D9P serine threonine protein kinase H3L99_RS10715 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H3L99_RS10720 ENOG4107XFJ UPF0246 protein H3L99_RS10725 ENOG4108UHU Aldolase H3L99_RS10750 ENOG4105EGD dinuclear metal center protein, YbgI family H3L99_RS10755 ENOG4108MES Periplasmic binding protein H3L99_RS10765 ENOG4105CHR reductase H3L99_RS10780 ENOG4105BZU Histidine kinase H3L99_RS10800 ENOG4107TXC Transcriptional regulator H3L99_RS10845 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold H3L99_RS10850 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H3L99_RS10860 ENOG4105DYW oxidoreductase H3L99_RS10875 ENOG4107QVI Methyltransferase, type 11 H3L99_RS10880 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) H3L99_RS10930 ENOG4105BZ1 (ABC) transporter H3L99_RS10940 ENOG4105F2C Acetyl-CoA acetyltransferase H3L99_RS10945 ENOG4106A3M Cytochrome p-450 H3L99_RS10950 ENOG4108J4B Beta-lactamase H3L99_RS11015 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 H3L99_RS11055 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase H3L99_RS11070 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) H3L99_RS11085 ENOG41081F0 Precorrin-8x methylmutase H3L99_RS11095 ENOG4105CTK cobaltochelatase, cobn subunit H3L99_RS11130 ENOG41088CC tellurite resistance protein tehB H3L99_RS11225 ENOG4105BZU Histidine kinase H3L99_RS11230 ENOG4107T5V SNARE associated Golgi H3L99_RS11240 ENOG4105DAX Pfam:DUF2983 H3L99_RS11285 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H3L99_RS11290 ENOG4105EYW Ion transport protein H3L99_RS11320 ENOG4105BZU Histidine kinase H3L99_RS11325 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS11340 ENOG4105CPC Aldo Keto reductase H3L99_RS11345 ENOG4105VUF Transcriptional regulator H3L99_RS11365 ENOG41065SU Two-component system sensor kinase H3L99_RS11370 ENOG4108KXV response regulator H3L99_RS11415 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF H3L99_RS11440 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H3L99_RS11445 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H3L99_RS11465 ENOG4105NGS secreted protein H3L99_RS11485 ENOG4108ZHJ Organic hydroperoxide resistance protein H3L99_RS11490 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H3L99_RS11510 ENOG4105DFF Rod shape-determining protein mreb H3L99_RS11520 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS11525 ENOG4105D8K carboxyl transferase H3L99_RS11605 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H3L99_RS11615 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein H3L99_RS11630 ENOG4108UB4 uncharacterized protein ygjQ H3L99_RS11640 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H3L99_RS11695 ENOG4108IFG nitrite reductase, (NAD(P)H) H3L99_RS11700 ENOG4107QZF nitrite reductase NADPH large subunit H3L99_RS11725 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H3L99_RS11750 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) H3L99_RS11755 ENOG4105DSE periplasmic solute binding protein H3L99_RS11760 ENOG4105FDK ABC transporter H3L99_RS11815 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H3L99_RS11820 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) H3L99_RS11840 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS11845 ENOG4105BZU Histidine kinase H3L99_RS11850 ENOG4105EYF MMPL domain protein H3L99_RS11860 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H3L99_RS11865 ENOG4105D4Y metalloprotease H3L99_RS11875 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H3L99_RS11895 ENOG4105MSB protein, conserved in bacteria H3L99_RS11905 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H3L99_RS11915 ENOG4107T4Z adenosine kinase H3L99_RS11930 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H3L99_RS11935 ENOG4107YU2 histidine triad (hIT) protein H3L99_RS11940 ENOG4107RE3 peptidase, S41 H3L99_RS11965 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H3L99_RS11970 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) H3L99_RS12000 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H3L99_RS12005 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) H3L99_RS12020 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase H3L99_RS12035 ENOG4105KQC Competence protein H3L99_RS12040 ENOG4105EPR degv family H3L99_RS12060 ENOG4107QIZ NADH dehydrogenase H3L99_RS12080 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H3L99_RS12095 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) H3L99_RS12105 ENOG4105D0M Protease HtpX homolog H3L99_RS12120 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) H3L99_RS12130 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H3L99_RS12140 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H3L99_RS12150 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase H3L99_RS12160 ENOG4107V9E glucose-1-phosphate thymidylyltransferase H3L99_RS12165 ENOG4105K64 Glycosyl transferase, family 2 H3L99_RS12180 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) H3L99_RS12190 ENOG4108I69 Glycosyl transferases group 1 H3L99_RS12200 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H3L99_RS12205 ENOG4105K46 50S ribosomal protein l27 H3L99_RS12210 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H3L99_RS12215 ENOG4105C03 ribonuclease H3L99_RS12255 ENOG4105CNI cell division protein FtsW H3L99_RS12260 ENOG4105CJN penicillin-binding protein H3L99_RS12275 ENOG4105DFF Rod shape-determining protein mreb H3L99_RS12280 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H3L99_RS12290 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H3L99_RS12295 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H3L99_RS12310 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H3L99_RS12315 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H3L99_RS12320 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation H3L99_RS12365 ENOG4108TGC Acyltransferase H3L99_RS12375 ENOG4107S91 Sodium hydrogen exchanger H3L99_RS12400 ENOG4105C85 amino acid H3L99_RS12410 ENOG4105C85 amino acid H3L99_RS12415 ENOG4105C85 amino acid H3L99_RS12420 ENOG4105MC2 DSBA oxidoreductase H3L99_RS12460 ENOG4105GR3 Histidine kinase H3L99_RS12480 ENOG4108X7A Terpene synthase metal-binding domain-containing protein H3L99_RS12510 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 H3L99_RS12520 ENOG4105D8X mechanosensitive ion channel H3L99_RS12545 ENOG4105F8D glycoside hydrolase family 4 H3L99_RS12560 ENOG4105CT1 (ABC) transporter H3L99_RS12590 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) H3L99_RS12610 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS12635 ENOG4105VHU single-stranded DNA-binding protein H3L99_RS12700 ENOG4105CJ1 ABC, transporter H3L99_RS12705 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin H3L99_RS12720 ENOG4105C26 Dehydrogenase H3L99_RS12725 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) H3L99_RS12730 ENOG4105DH8 myo-inositol catabolism H3L99_RS12770 ENOG4105C7H Helicase, RecD TraA family H3L99_RS12825 ENOG41060NJ transcriptional regulator H3L99_RS12835 ENOG4105VCT ion-transport protein YfeO H3L99_RS12840 ENOG410645S MarR family Transcriptional regulator H3L99_RS12870 ENOG4105D17 glycoside hydrolase, family 3 domain protein H3L99_RS12915 ENOG4105CJ1 ABC, transporter H3L99_RS12920 ENOG4105BZU Histidine kinase H3L99_RS12925 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS12930 ENOG4105C7K acetolactate synthase H3L99_RS12940 ENOG4105CK7 Sodium proline symporter H3L99_RS12965 ENOG4105C29 acyl-CoA thioesterase H3L99_RS12970 ENOG4105BZU Histidine kinase H3L99_RS12975 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS12985 ENOG4108XFF H3L99_RS12995 ENOG4107QX3 carboxylase H3L99_RS13005 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H3L99_RS13010 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS13020 ENOG4105Q26 Siderophore-interacting protein H3L99_RS13030 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) H3L99_RS13040 ENOG4105DUU IucA IucC family protein H3L99_RS13045 ENOG4105E2D ec 3.2.1.52 H3L99_RS13055 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H3L99_RS13075 ENOG4105ECQ AraC Family Transcriptional Regulator H3L99_RS13080 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) H3L99_RS13095 ENOG4108KPJ rna polymerase sigma factor H3L99_RS13100 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H3L99_RS13115 ENOG4108Z6Z Transcriptional regulator H3L99_RS13120 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS13135 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component H3L99_RS13145 ENOG410804D Sensor Signal Transduction Histidine Kinase H3L99_RS13220 ENOG4105BZU Histidine kinase H3L99_RS13230 ENOG4105DEN Luciferase family H3L99_RS13240 ENOG4105E98 transcriptional regulator DeoR family H3L99_RS13255 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component H3L99_RS13265 ENOG4108JQ1 Dehydrogenase H3L99_RS13280 ENOG4105C5I Dehydrogenase H3L99_RS13285 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H3L99_RS13330 ENOG4108M1A Chitin-binding protein H3L99_RS13360 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) H3L99_RS13390 ENOG4105D9R oxidoreductase H3L99_RS13395 ENOG41090KN UPF0303 protein H3L99_RS13405 ENOG4105KK4 UPF0060 membrane protein H3L99_RS13410 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H3L99_RS13420 ENOG4105DFW ABC transporter H3L99_RS13425 ENOG4108U4N (sortase) family H3L99_RS13490 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation H3L99_RS13550 ENOG4106BRA Membrane H3L99_RS13565 ENOG4108IUW ABC transporter H3L99_RS13580 ENOG4105BZ4 penicillin-binding protein H3L99_RS13590 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) H3L99_RS13605 ENOG4105CSH Transporter H3L99_RS13625 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H3L99_RS13635 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H3L99_RS13655 ENOG4108RQ5 Beta-lactamase domain-containing protein H3L99_RS13675 ENOG4105C85 amino acid H3L99_RS13685 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) H3L99_RS13695 ENOG4108RWI nicotinamidase H3L99_RS13725 ENOG4105KF0 sporulation and cell division protein, SsgA H3L99_RS13730 ENOG4105CQB FAD linked oxidase domain protein H3L99_RS13740 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase H3L99_RS13825 ENOG4108762 serine threonine protein kinase H3L99_RS13865 ENOG4105E2D ec 3.2.1.52 H3L99_RS13890 ENOG4108UJU UPF0301 protein H3L99_RS13895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H3L99_RS13900 ENOG4108426 dNA-binding protein H3L99_RS13910 ENOG4105EEM helicase H3L99_RS13960 ENOG4106NZI LysR family Transcriptional regulator H3L99_RS13975 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H3L99_RS13990 ENOG4105CAK Cell division ATP-binding protein ftsE H3L99_RS14005 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) H3L99_RS14010 ENOG4108QVN serine threonine protein kinase H3L99_RS14015 ENOG4108UGD Serine Threonine protein kinase H3L99_RS14020 ENOG4105EC2 ftsk spoIIIe H3L99_RS14035 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component H3L99_RS14055 ENOG4108JGH Tetr family transcriptional regulator H3L99_RS14065 ENOG4105EY8 ABC transporter H3L99_RS14075 ENOG4105C7I Dehydrogenase H3L99_RS14100 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H3L99_RS14110 ENOG4105T0Z Conserved Protein H3L99_RS14120 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea H3L99_RS14130 ENOG4105G3P Lipoprotein lpqB H3L99_RS14135 ENOG4105BZU Histidine kinase H3L99_RS14140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H3L99_RS14145 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) H3L99_RS14160 ENOG4108WQ6 secreted protein H3L99_RS14165 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H3L99_RS14205 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) H3L99_RS14215 ENOG4105EIP mannose-6-phosphate isomerase H3L99_RS14225 ENOG4105W49 UPF0434 protein H3L99_RS14230 ENOG4107QKV phosphomannomutase H3L99_RS14250 ENOG4107RGC Glycosyl transferase, family 2 H3L99_RS14255 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H3L99_RS14275 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) H3L99_RS14300 ENOG4108KGH TRANSCRIPTIONal H3L99_RS14305 ENOG4108KGH TRANSCRIPTIONal H3L99_RS14320 ENOG4108KGH TRANSCRIPTIONal H3L99_RS14325 ENOG4108S4H thioesterase Superfamily protein H3L99_RS14330 ENOG4108KGH TRANSCRIPTIONal H3L99_RS14345 ENOG4105C6Y Udp-glucose 6-dehydrogenase H3L99_RS14370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H3L99_RS14390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H3L99_RS14395 ENOG4105DUX Transporter H3L99_RS14430 ENOG41082AN stage II sporulation protein H3L99_RS14435 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS14465 ENOG4105CI2 imidazolone-5-propionate hydrolase H3L99_RS14480 ENOG4105CGP Urocanate hydratase H3L99_RS14485 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H3L99_RS14545 ENOG4105CHU acetyl-coa acetyltransferase H3L99_RS14575 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS14580 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS14585 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H3L99_RS14590 ENOG4105CEP NADH dehydrogenase H3L99_RS14615 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H3L99_RS14630 ENOG4106A3M Cytochrome p-450 H3L99_RS14655 ENOG4105EBM Alpha Beta Hydrolase Fold protein H3L99_RS14665 ENOG4105CKK Glycosyl transferase, family 2 H3L99_RS14720 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS14725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS14730 ENOG4105C0R drug resistance transporter emrb qaca subfamily H3L99_RS14745 ENOG4107QN1 sodium solute H3L99_RS14770 ENOG4105BZU Histidine kinase H3L99_RS14785 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H3L99_RS14790 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) H3L99_RS14795 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H3L99_RS14815 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) H3L99_RS14825 ENOG4108IG5 Transcriptional regulator H3L99_RS14835 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) H3L99_RS14840 ENOG4108ZT1 Transcriptional regulator H3L99_RS14845 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS14880 ENOG4105C5H ABC transporter H3L99_RS14890 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) H3L99_RS14895 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H3L99_RS14905 ENOG4105F8V Hydrolase, tatD family H3L99_RS14935 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H3L99_RS14955 ENOG4108ZHJ Organic hydroperoxide resistance protein H3L99_RS14965 ENOG4108JJB ABC transporter H3L99_RS14975 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) H3L99_RS14985 ENOG4105EYF MMPL domain protein H3L99_RS15010 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H3L99_RS15015 ENOG4108BAS reductase H3L99_RS15065 ENOG4108Z9I -acetyltransferase H3L99_RS15070 ENOG4108RIR Molybdenum cofactor biosynthesis protein H3L99_RS15075 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H3L99_RS15085 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H3L99_RS15090 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase H3L99_RS15095 ENOG4105CUJ penicillin amidase H3L99_RS15115 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) H3L99_RS15160 ENOG4108Z7F N-acetyltransferase H3L99_RS15165 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H3L99_RS15210 ENOG4105CHR reductase H3L99_RS15215 ENOG4108R86 Transcriptional regulator H3L99_RS15240 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H3L99_RS15265 ENOG4105DZ1 carboxypeptidase H3L99_RS15305 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) H3L99_RS15360 ENOG4105CNA YD repeat protein H3L99_RS15430 ENOG4105CUB amino acid H3L99_RS15480 ENOG4105F0K SARP family transcriptional regulator H3L99_RS15520 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS15545 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) H3L99_RS15570 ENOG4105D2B acyl-CoA dehydrogenase H3L99_RS15580 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) H3L99_RS15595 ENOG4105H3G oxidoreductase H3L99_RS15605 ENOG4105CGU Enoyl-CoA hydratase H3L99_RS15610 ENOG4105MXW flavin reductase domain protein, FMN-binding H3L99_RS15635 ENOG4107QPD alcohol dehydrogenase H3L99_RS15640 ENOG4105CC9 acyl-Coa dehydrogenase H3L99_RS15645 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr H3L99_RS15660 ENOG4105D2B acyl-CoA dehydrogenase H3L99_RS15665 ENOG4105CC9 acyl-Coa dehydrogenase H3L99_RS15675 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS15680 ENOG4107EG8 signal transduction protein with EFhand domain H3L99_RS15730 ENOG4105EPJ extracellular solute-binding protein family 1 H3L99_RS15785 ENOG4108XEP Alpha Beta Hydrolase Fold protein H3L99_RS15795 ENOG4108SU4 UPF0309 protein H3L99_RS15810 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) H3L99_RS15845 ENOG4107QX3 carboxylase H3L99_RS15870 ENOG4107AQZ Membrane H3L99_RS15875 ENOG4106NZI LysR family Transcriptional regulator H3L99_RS15880 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) H3L99_RS15895 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) H3L99_RS15985 ENOG4105CPC Aldo Keto reductase H3L99_RS16015 ENOG4105C7N Xanthine uracil vitamin C permease H3L99_RS16025 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic H3L99_RS16045 ENOG4107R6F Alpha Beta Hydrolase Fold protein H3L99_RS16055 ENOG4105WN5 stage II sporulation protein H3L99_RS16085 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS16095 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS16135 ENOG4108N0W Major Facilitator superfamily H3L99_RS16145 ENOG4108UIH futalosine nucleosidase H3L99_RS16150 ENOG4105E63 Pfam:DUF178 H3L99_RS16155 ENOG4105VEQ Cold shock protein H3L99_RS16170 ENOG4105DQ5 transport system permease protein H3L99_RS16175 ENOG4105TVJ transport system, permease H3L99_RS16180 ENOG4105E0A ABC, transporter H3L99_RS16185 ENOG4108HUF Transporter H3L99_RS16205 ENOG4105CFI type iii restriction protein res subunit H3L99_RS16225 ENOG4108JJB ABC transporter H3L99_RS16230 ENOG4105EEM helicase H3L99_RS16265 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H3L99_RS16270 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H3L99_RS16290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS16355 ENOG4105C3Q Glycosyl transferase, family 2 H3L99_RS16390 ENOG4105CE4 GlcNAc 6-P deacetylase H3L99_RS16395 ENOG4105DE4 1-phosphofructokinase H3L99_RS16405 ENOG4105BZU Histidine kinase H3L99_RS16415 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H3L99_RS16435 ENOG4105BZU Histidine kinase H3L99_RS16440 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS16475 ENOG4105CJP fad dependent oxidoreductase H3L99_RS16500 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) H3L99_RS16510 ENOG4105C2N RNA methyltransferase TrmH family group 3 H3L99_RS16515 ENOG4105C8N cysteinyl-tRNA synthetase H3L99_RS16520 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) H3L99_RS16525 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) H3L99_RS16530 ENOG4108VJ1 Transcriptional regulator (CarD family H3L99_RS16545 ENOG4105BZU Histidine kinase H3L99_RS16595 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H3L99_RS16605 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H3L99_RS16635 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) H3L99_RS16655 ENOG4105TT9 Protein of unknown function (DUF2516) H3L99_RS16680 ENOG4107S5I aldo keto reductase H3L99_RS16715 ENOG4105FDP GntR family transcriptional regulator H3L99_RS16735 ENOG4105HHS UPF0256 protein H3L99_RS16750 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H3L99_RS16755 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) H3L99_RS16765 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands H3L99_RS16795 ENOG4105PKJ carbohydrate binding H3L99_RS16800 ENOG4105KHC sulfurtransferase H3L99_RS16825 ENOG4107NHD transcriptional regulator H3L99_RS16830 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS16835 ENOG4105C0H protease H3L99_RS16860 ENOG4105CGH 5'-nucleotidase H3L99_RS16865 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) H3L99_RS16870 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family H3L99_RS16875 ENOG4105CZV ABC transporter H3L99_RS16885 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H3L99_RS16900 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H3L99_RS16915 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H3L99_RS16920 ENOG4105CJ3 phosphate transporter H3L99_RS16930 ENOG4105VPX protein, conserved in bacteria H3L99_RS16950 ENOG4105DNP FAD linked oxidase domain protein H3L99_RS16955 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H3L99_RS16960 ENOG4105E4C Lytic transglycosylase catalytic H3L99_RS17010 ENOG4105CJ1 ABC, transporter H3L99_RS17020 ENOG4105BZU Histidine kinase H3L99_RS17025 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS17045 ENOG41082F9 transcriptional regulator H3L99_RS17085 ENOG4105D5U fad dependent oxidoreductase H3L99_RS17090 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H3L99_RS17100 ENOG4105CPC Aldo Keto reductase H3L99_RS17105 ENOG4105E4C Lytic transglycosylase catalytic H3L99_RS17120 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H3L99_RS17125 ENOG41081JD Transcriptional regulator H3L99_RS17130 ENOG4105DXX methyltransferase H3L99_RS17160 ENOG41083TI Protein CrcB homolog H3L99_RS17165 ENOG41083YR Protein CrcB homolog H3L99_RS17195 ENOG4107QIV Cytochrome c biogenesis protein H3L99_RS17200 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H3L99_RS17210 ENOG4105CQ7 ATP-dependent helicase H3L99_RS17230 ENOG4108TAC H3L99_RS17235 ENOG4107RDP Dehydrogenase H3L99_RS17245 ENOG4105CXB phosphoribosylaminoimidazole synthetase H3L99_RS17275 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii H3L99_RS17280 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I H3L99_RS17285 ENOG410839H phosphoribosylformylglycinamidine synthase H3L99_RS17310 ENOG4105C8V SAICAR synthetase H3L99_RS17325 ENOG4105C12 Phosphoribosylglycinamide synthetase H3L99_RS17365 ENOG4105CHP RNA polymerase H3L99_RS17390 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H3L99_RS17405 ENOG4108Z6B deaminase H3L99_RS17420 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein H3L99_RS17425 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS17430 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS17445 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes H3L99_RS17455 ENOG4108YYC ycei family H3L99_RS17460 ENOG410905P Pyridoxamine 5-phosphate H3L99_RS17470 ENOG4105C57 major facilitator superfamily H3L99_RS17475 ENOG4105EDW glycosyl transferase, family 39 H3L99_RS17475 ENOG4105EDW glycosyl transferase, family 39 H3L99_RS17485 ENOG4105BZU Histidine kinase H3L99_RS17490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H3L99_RS17500 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin H3L99_RS17540 ENOG4108UXN response regulator H3L99_RS17545 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS17550 ENOG4105NAF rna polymerase sigma factor H3L99_RS17580 ENOG4105GFG DUF218 domain H3L99_RS17595 ENOG4105C0H protease H3L99_RS17630 ENOG4107T6F Xaa-Pro aminopeptidase H3L99_RS17660 ENOG4105JDN Copper resistance protein H3L99_RS17665 ENOG4105DBE peroxidase H3L99_RS17670 ENOG4105CQC Prephenate dehydratase H3L99_RS17675 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H3L99_RS17680 ENOG4105DQF Hydrolase H3L99_RS17705 ENOG4105DA5 (ABC) transporter H3L99_RS17715 ENOG4107SWG transcriptional regulator MERR family H3L99_RS17720 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) H3L99_RS17730 ENOG4108K4B hydrolase H3L99_RS17735 ENOG4105E4C Lytic transglycosylase catalytic H3L99_RS17745 ENOG4108JJ9 ABC, transporter H3L99_RS17750 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H3L99_RS17755 ENOG4105C4M (Ubiquinol oxidase) subunit I H3L99_RS17760 ENOG4105CIH Imidazole acetol-phosphate transaminase H3L99_RS17765 ENOG4107P2S Transcriptional regulator H3L99_RS17770 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) H3L99_RS17780 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) H3L99_RS17805 ENOG4106048 Cupin 2, conserved barrel domain protein H3L99_RS17810 ENOG41082T9 Membrane H3L99_RS17815 ENOG4105KJF protein tyrosine phosphatase H3L99_RS17820 ENOG4105C28 cystathionine H3L99_RS17860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H3L99_RS17905 ENOG4105CDU Replicative dna helicase H3L99_RS17915 ENOG4105K9Q Binds to the 23S rRNA (By similarity) H3L99_RS17920 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H3L99_RS17925 ENOG4107YH6 single-stranded DNA-binding protein H3L99_RS17930 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) H3L99_RS17955 ENOG4105BZ4 penicillin-binding protein H3L99_RS17980 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate H3L99_RS17995 ENOG4105D9P serine threonine protein kinase H3L99_RS18010 ENOG4105C3M thioredoxin reductase H3L99_RS18015 ENOG4105K63 Thioredoxin H3L99_RS18030 ENOG4107QJE Chromosome Partitioning Protein H3L99_RS18035 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) H3L99_RS18045 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H3L99_RS18050 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H3L99_RS18055 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) H3L99_RS18065 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) H3L99_RS18070 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H3L99_RS18075 ENOG4108J5G 6-phosphogluconate dehydrogenase H3L99_RS18080 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H3L99_RS18085 ENOG4105K7N UPF0232 protein H3L99_RS18095 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H3L99_RS18125 ENOG4108UGD Serine Threonine protein kinase H3L99_RS18175 ENOG4108IUX (ABC) transporter H3L99_RS18190 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone H3L99_RS18195 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H3L99_RS18240 ENOG4107ZXI Rhomboid family H3L99_RS18245 ENOG4105ZJT Cell division protein CrgA H3L99_RS18255 ENOG4108U4N (sortase) family H3L99_RS18270 ENOG4108U4N (sortase) family H3L99_RS18275 ENOG4108RN7 integral membrane protein H3L99_RS18285 ENOG4105CJN penicillin-binding protein H3L99_RS18300 ENOG4105HZM Fha domain containing protein H3L99_RS18305 ENOG4105TV9 FHA Domain-Containing protein H3L99_RS18325 ENOG41085GJ domain protein H3L99_RS18330 ENOG4108KC2 acyl-Coa dehydrogenase H3L99_RS18335 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H3L99_RS18340 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit H3L99_RS18345 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit H3L99_RS18350 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit H3L99_RS18355 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit H3L99_RS18380 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H3L99_RS18385 ENOG4108IG5 Transcriptional regulator H3L99_RS18405 ENOG4107QSN dihydrolipoamide acetyltransferase H3L99_RS18420 ENOG4107SVH Potassium channel protein H3L99_RS18425 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H3L99_RS18440 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H3L99_RS18455 ENOG4107QPV Serine Threonine protein kinase H3L99_RS18485 ENOG4105CPP Dehydrogenase, E1 component H3L99_RS18490 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 H3L99_RS18500 ENOG4105DJB Major Facilitator Superfamily H3L99_RS18535 ENOG4105DFM M18 family aminopeptidase H3L99_RS18540 ENOG4105CSU acyl-Coa dehydrogenase H3L99_RS18550 ENOG4105EUB pirin domain protein H3L99_RS18565 ENOG4105C9M aspartyl-trna synthetase H3L99_RS18590 ENOG4105MUA Resistance protein H3L99_RS18615 ENOG4105EM2 membrane H3L99_RS18650 ENOG4108UZX fmn reductase H3L99_RS18665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H3L99_RS18685 ENOG4107SVH Potassium channel protein H3L99_RS18700 ENOG4107S46 esterase, PHB depolymerase H3L99_RS18745 ENOG4105BZG amino acid carrier protein H3L99_RS18765 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) H3L99_RS18780 ENOG4107TJV N-acetylglutamate semialdehyde dehydrogenase H3L99_RS18785 ENOG4107SBK Acetylornithine deacetylase H3L99_RS18800 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H3L99_RS18820 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS18865 ENOG4105CIH Imidazole acetol-phosphate transaminase H3L99_RS18880 ENOG4105DHP deoxycytidine triphosphate deaminase H3L99_RS18900 ENOG4105DF6 Fe-S oxidoreductase H3L99_RS18905 ENOG4105D3Q Sugar transferase H3L99_RS18910 ENOG4105CFG Acts as a chaperone (By similarity) H3L99_RS18915 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H3L99_RS18920 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H3L99_RS18925 ENOG4105KNI merR family transcriptional Regulator H3L99_RS18955 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H3L99_RS18980 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) H3L99_RS18995 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) H3L99_RS19000 ENOG4107RCW fructose-bisphosphate aldolase H3L99_RS19005 ENOG4105C87 Aminotransferase class I and II H3L99_RS19030 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) H3L99_RS19050 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS19055 ENOG4106A3M Cytochrome p-450 H3L99_RS19060 ENOG4105DIM ABC transporter H3L99_RS19065 ENOG4105CIG ABC transporter H3L99_RS19080 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H3L99_RS19090 ENOG4105CVA phosphate H3L99_RS19120 ENOG4108V4B ThiJ pfpI H3L99_RS19125 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H3L99_RS19135 ENOG4105DRR Transcriptional regulator, GntR family H3L99_RS19150 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H3L99_RS19155 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H3L99_RS19165 ENOG4105CFH Aspartokinase H3L99_RS19175 ENOG4105NAF rna polymerase sigma factor H3L99_RS19245 ENOG41090CE integral membrane protein H3L99_RS19250 ENOG4105KTH gatB Yqey H3L99_RS19255 ENOG4105BZ4 penicillin-binding protein H3L99_RS19290 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H3L99_RS19310 ENOG4105P8F nudix hydrolase H3L99_RS19320 ENOG4105D74 hydrolase H3L99_RS19330 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H3L99_RS19335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H3L99_RS19340 ENOG4105CHH sulfate transporter H3L99_RS19400 ENOG4108I5C dEAD DEAH box helicase H3L99_RS19405 ENOG4105WN5 stage II sporulation protein H3L99_RS19410 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) H3L99_RS19415 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for H3L99_RS19425 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H3L99_RS19435 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H3L99_RS19440 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) H3L99_RS19445 ENOG4105FA2 dna polymerase iii H3L99_RS19490 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H3L99_RS19495 ENOG4105CPF Cell wall formation (By similarity) H3L99_RS19505 ENOG4107QSI ABC, transporter H3L99_RS19555 ENOG4107QKG PfaD family H3L99_RS19560 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS19600 ENOG4105D8K carboxyl transferase H3L99_RS19605 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H3L99_RS19610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H3L99_RS19625 ENOG4105DJI Methylaspartate mutase, E subunit H3L99_RS19640 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H3L99_RS19645 ENOG4105CFH Aspartokinase H3L99_RS19665 ENOG4107V2S Transcriptional regulator H3L99_RS19675 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H3L99_RS19690 ENOG4105C2M dna polymerase I H3L99_RS19695 ENOG4108UW5 maltose o-acetyltransferase H3L99_RS19710 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H3L99_RS19730 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H3L99_RS19735 ENOG4105KDC 50s ribosomal protein l28 H3L99_RS19745 ENOG4105NRA 50s ribosomal protein l31 type b H3L99_RS19755 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H3L99_RS19775 ENOG4105C26 Dehydrogenase H3L99_RS19800 ENOG4105CVK Glutamate decarboxylase H3L99_RS19805 ENOG4107TXC Transcriptional regulator H3L99_RS19810 ENOG41082VC UPF0145 protein H3L99_RS19815 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN H3L99_RS19825 ENOG4105F0N pyrophosphate phospho-hydrolase H3L99_RS19840 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H3L99_RS19845 ENOG4108UGV hypoxanthine phosphoribosyltransferase H3L99_RS19855 ENOG4105EUJ GTP cyclohydrolase i H3L99_RS19860 ENOG4107S5I aldo keto reductase H3L99_RS19870 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H3L99_RS19890 ENOG4105CRK lysyL-tRNA synthetase H3L99_RS19900 ENOG4108IJ8 ABC transporter H3L99_RS19905 ENOG4105E90 ABC transporter H3L99_RS19910 ENOG4105E90 ABC transporter H3L99_RS19915 ENOG4108HQR Glycine betaine H3L99_RS19925 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS19940 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS19945 ENOG41082SX arsR family transcriptional regulator H3L99_RS19965 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) H3L99_RS19970 ENOG4108IYU L-aspartate oxidase H3L99_RS19980 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) H3L99_RS20020 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family H3L99_RS20025 ENOG4105DR5 peptidase H3L99_RS20030 ENOG4108FKE two-component system sensor kinase H3L99_RS20035 ENOG4108PYU two-component system response regulator H3L99_RS20040 ENOG41075QH Lipoprotein CseA H3L99_RS20045 ENOG4105NAF rna polymerase sigma factor H3L99_RS20050 ENOG4105CEN a g-specific adenine glycosylase H3L99_RS20055 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H3L99_RS20065 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) H3L99_RS20080 ENOG4108JWX H3L99_RS20085 ENOG4107R33 ppx gppa phosphatase H3L99_RS20090 ENOG4105EY0 Xylose isomerase domain protein TIM barrel H3L99_RS20100 ENOG4105C01 Dihydroxy-acid dehydratase H3L99_RS20110 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein H3L99_RS20120 ENOG4105CJ1 ABC, transporter H3L99_RS20130 ENOG4105II7 pyrroline-5-carboxylate reductase H3L99_RS20135 ENOG4105C31 Tryptophanyl-tRNA synthetase H3L99_RS20155 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 H3L99_RS20165 ENOG4105DGU Histone deacetylase H3L99_RS20170 ENOG4108XFF H3L99_RS20215 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) H3L99_RS20220 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H3L99_RS20225 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H3L99_RS20230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H3L99_RS20235 ENOG41089UC methyltransferase, type 11 H3L99_RS20240 ENOG4105D52 delta-aminolevulinic acid dehydratase H3L99_RS20270 ENOG4105EBR Carboxylesterase H3L99_RS20295 ENOG4105C75 arginyL-tRNA synthetase H3L99_RS20300 ENOG4105DK7 lysyl-tRNA synthetase H3L99_RS20325 ENOG4105E0Y RtcB Protein H3L99_RS20345 ENOG4107SCK Monooxygenase H3L99_RS20390 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H3L99_RS20395 ENOG4108RH7 phosphoglycerate mutase H3L99_RS20405 ENOG4107ZT5 Thiol disulfide interchange protein H3L99_RS20415 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) H3L99_RS20420 ENOG4105CRE cytochrome C H3L99_RS20440 ENOG4107V2S Transcriptional regulator H3L99_RS20450 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H3L99_RS20460 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H3L99_RS20470 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H3L99_RS20485 ENOG4105DVY radical SAM domain protein H3L99_RS20500 ENOG4107QJT sodium dicarboxylate symporter H3L99_RS20515 ENOG4108R86 Transcriptional regulator H3L99_RS20525 ENOG4105CHR reductase H3L99_RS20535 ENOG4105VEQ Cold shock protein H3L99_RS20540 ENOG4105EV6 Pfam:DUF178 H3L99_RS20550 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) H3L99_RS20560 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H3L99_RS20565 ENOG4105CSV Glutaminase H3L99_RS20595 ENOG4105FQP Beta-lactamase H3L99_RS20615 ENOG4105ECQ AraC Family Transcriptional Regulator H3L99_RS20625 ENOG41068JE domain protein H3L99_RS20635 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20640 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H3L99_RS20645 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20655 ENOG4107QIZ NADH dehydrogenase H3L99_RS20660 ENOG4108IEH NADH dehydrogenase subunit g H3L99_RS20665 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H3L99_RS20670 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20675 ENOG41087XN oxidoreductase H3L99_RS20680 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20685 ENOG4105D65 subunit l H3L99_RS20695 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20700 ENOG410874W AraC family transcriptional regulator H3L99_RS20705 ENOG4106T9R serine protease H3L99_RS20730 ENOG4105CJ1 ABC, transporter H3L99_RS20740 ENOG4105IIU Aminopeptidase H3L99_RS20770 ENOG4105ECR NmrA family H3L99_RS20775 ENOG4105KVH Transcriptional regulator H3L99_RS20780 ENOG4105DQU oxidoreductase, subunit beta H3L99_RS20785 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein H3L99_RS20810 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20815 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H3L99_RS20820 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H3L99_RS20830 ENOG4107YX3 NADH dehydrogenase subunit j H3L99_RS20835 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20845 ENOG4105C8S subunit m H3L99_RS20850 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H3L99_RS20855 ENOG4105D0M Protease HtpX homolog H3L99_RS20860 ENOG410901E Membrane H3L99_RS20870 ENOG4105Y3U Transglycosylase-associated protein H3L99_RS20880 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H3L99_RS20885 ENOG4108VPT UPF0234 protein H3L99_RS20915 ENOG4105DZC cytosine deaminase H3L99_RS20930 ENOG4105WDJ 50S ribosomal protein L33 H3L99_RS20935 ENOG410900P UPF0336 protein H3L99_RS20955 ENOG4107R4N Cell wall formation (By similarity) H3L99_RS20990 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H3L99_RS20995 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) H3L99_RS21005 ENOG4105QCJ Lipoprotein H3L99_RS21010 ENOG4108VZM 50s ribosomal protein L10 H3L99_RS21020 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H3L99_RS21025 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H3L99_RS21030 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H3L99_RS21035 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H3L99_RS21040 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H3L99_RS21045 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H3L99_RS21065 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) H3L99_RS21070 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H3L99_RS21075 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H3L99_RS21080 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) H3L99_RS21085 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H3L99_RS21090 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) H3L99_RS21095 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) H3L99_RS21100 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H3L99_RS21105 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) H3L99_RS21110 ENOG41082SA 50s ribosomal protein l29 H3L99_RS21115 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H3L99_RS21120 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) H3L99_RS21125 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H3L99_RS21130 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits H3L99_RS21135 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H3L99_RS21140 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H3L99_RS21145 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H3L99_RS21150 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H3L99_RS21155 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H3L99_RS21160 ENOG410849U 50S ribosomal protein L30 H3L99_RS21165 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) H3L99_RS21170 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H3L99_RS21175 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H3L99_RS21185 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H3L99_RS21195 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H3L99_RS21205 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H3L99_RS21210 ENOG4108ZT0 50S ribosomal protein l17 H3L99_RS21215 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H3L99_RS21230 ENOG4105C5H ABC transporter H3L99_RS21235 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H3L99_RS21240 ENOG4108UJD 30S ribosomal protein S9 H3L99_RS21245 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H3L99_RS21255 ENOG4105CS9 pantothenic acid kinase H3L99_RS21275 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H3L99_RS21290 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H3L99_RS21295 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 H3L99_RS21300 ENOG4108097 ATP-binding protein H3L99_RS21325 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H3L99_RS21340 ENOG4105CHP RNA polymerase H3L99_RS21405 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H3L99_RS21415 ENOG4105EMU Dehydrogenase H3L99_RS21425 ENOG4105DND Transcriptional regulator H3L99_RS21430 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H3L99_RS21440 ENOG4108MMM RNA Polymerase H3L99_RS21450 ENOG4107QVP Dehydrogenase H3L99_RS21460 ENOG4107QQG Dehydrogenase H3L99_RS21465 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H3L99_RS21480 ENOG4107TPY serine threonine protein kinase H3L99_RS21485 ENOG4105C26 Dehydrogenase H3L99_RS21505 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H3L99_RS21535 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS21545 ENOG4105K4H Nlp p60 protein H3L99_RS21595 ENOG4105KKX ATPase associated with various cellular activities aaa_5 H3L99_RS21600 ENOG4105RD5 H3L99_RS21605 ENOG4105DEG Vwa containing coxe family protein H3L99_RS21620 ENOG4105CMV Succinyl-CoA synthetase subunit beta H3L99_RS21650 ENOG4105DC1 bifunctional purine biosynthesis protein purh H3L99_RS21665 ENOG4105D9P serine threonine protein kinase H3L99_RS21680 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H3L99_RS21700 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H3L99_RS21745 ENOG4108IJ7 Glycine betaine H3L99_RS21750 ENOG4108HQS Glycine betaine H3L99_RS21770 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H3L99_RS21780 ENOG4105C8Y Acetylornithine aminotransferase H3L99_RS21785 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H3L99_RS21800 ENOG4105EMN RNA polymerase sigma factor H3L99_RS21805 ENOG4105C31 Tryptophanyl-tRNA synthetase H3L99_RS21830 ENOG4107RN3 metallophosphoesterase H3L99_RS21835 ENOG41067SE Tetr family transcriptional regulator H3L99_RS21880 ENOG4108J01 L-aspartate oxidase H3L99_RS21900 ENOG4105E2D ec 3.2.1.52 H3L99_RS21965 ENOG4108ZX0 Signal peptidase I H3L99_RS22025 ENOG4108MMM RNA Polymerase H3L99_RS22050 ENOG4108NIW Leucine export protein LeuE H3L99_RS22060 ENOG4105K64 Glycosyl transferase, family 2 H3L99_RS22070 ENOG4105F0R Cytidylyltransferase H3L99_RS22075 ENOG4105D2T synthase H3L99_RS22085 ENOG4107RM1 amidohydrolase H3L99_RS22090 ENOG4105DIH basic membrane H3L99_RS22095 ENOG4108JQ9 ABC transporter H3L99_RS22130 ENOG4105D94 Major Facilitator Superfamily H3L99_RS22135 ENOG4107RSM transcriptional regulator H3L99_RS22150 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H3L99_RS22175 ENOG41065SU Two-component system sensor kinase H3L99_RS22180 ENOG4108KXV response regulator H3L99_RS22185 ENOG4105NAF rna polymerase sigma factor H3L99_RS22205 ENOG4105C26 Dehydrogenase H3L99_RS22220 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain H3L99_RS22250 ENOG4108JIK carboxylase H3L99_RS22260 ENOG4107WR6 Maf-like protein H3L99_RS22280 ENOG4105D8K carboxyl transferase H3L99_RS22290 ENOG4108QER Adenylate cyclase H3L99_RS22295 ENOG4105E39 Enoyl-CoA hydratase H3L99_RS22300 ENOG4105KDM Diguanylate cyclase with gaf sensor H3L99_RS22305 ENOG4105C84 Histidine ammonia-lyase H3L99_RS22320 ENOG4105FF0 ErfK YbiS YcfS YnhG H3L99_RS22355 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H3L99_RS22380 ENOG4105NAF rna polymerase sigma factor H3L99_RS22390 ENOG4105C7B Threonine dehydratase H3L99_RS22405 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H3L99_RS22415 ENOG4105T1M mycothiol conjugate amidase mca H3L99_RS22430 ENOG4108KB2 LysR family Transcriptional regulator H3L99_RS22460 ENOG4105C7Z Conserved Protein H3L99_RS22495 ENOG4105C57 major facilitator superfamily H3L99_RS22505 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) H3L99_RS22525 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H3L99_RS22560 ENOG4105CPK Glycosyl transferase (Group 1 H3L99_RS22565 ENOG4105D3Q Sugar transferase H3L99_RS22575 ENOG4105CJR Integral membrane protein (MviN H3L99_RS22585 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) H3L99_RS22675 ENOG4108FUF Transcriptional regulator, IclR family H3L99_RS22680 ENOG4105KME endoribonuclease L-psp H3L99_RS22685 ENOG4105C6Z Gluconate H3L99_RS22725 ENOG4105D1F ATP-binding protein H3L99_RS22765 ENOG4107QKZ Ompa motb domain protein H3L99_RS22795 ENOG4105CPC Aldo Keto reductase H3L99_RS22800 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H3L99_RS22805 ENOG4108IAB Phoh family H3L99_RS22825 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H3L99_RS22830 ENOG4105D3R alkyl hydroperoxide reductase H3L99_RS22860 ENOG4105BZ4 penicillin-binding protein H3L99_RS22875 ENOG4105C9Q fumarate hydratase class II H3L99_RS22885 ENOG4105GFR rna polymerase sigma factor H3L99_RS22895 ENOG4107GFK fumarate H3L99_RS22900 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin H3L99_RS22915 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H3L99_RS22930 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) H3L99_RS22935 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H3L99_RS22940 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H3L99_RS22950 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) H3L99_RS22965 ENOG4105C3G gtp-binding protein H3L99_RS22970 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H3L99_RS22985 ENOG4107ZVI PhiRv2 prophage protein H3L99_RS23050 ENOG4108F3G Type I restriction-modification system, R subunit H3L99_RS23060 ENOG4105CVR type I restriction-modification system H3L99_RS23075 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H3L99_RS23085 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin H3L99_RS23125 ENOG41087YS Phage shock protein A H3L99_RS23165 ENOG4105CI3 gtp-binding protein typa H3L99_RS23170 ENOG4108J59 Extracellular solute-binding protein, family 5 H3L99_RS23175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H3L99_RS23180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS23190 ENOG4108JQ7 (ABC) transporter H3L99_RS23210 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H3L99_RS23215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS23225 ENOG4108JQ7 (ABC) transporter H3L99_RS23245 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) H3L99_RS23270 ENOG4105CNA YD repeat protein H3L99_RS23290 ENOG4108Z4U Ferredoxin H3L99_RS23310 ENOG4107R4C succinyl-diaminopimelate desuccinylase H3L99_RS23315 ENOG4108URH decarboxylase H3L99_RS23320 ENOG4105EEI dihydropteroate synthase H3L99_RS23330 ENOG4108R3E Dna-3-methyladenine glycosylase i H3L99_RS23335 ENOG4108UKI Enoyl-CoA hydratase H3L99_RS23350 ENOG4105DU6 RNA polymerase H3L99_RS23365 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) H3L99_RS23400 ENOG4105D7N magnesium and cobalt transport protein CorA H3L99_RS23420 ENOG41081FY multiple antibiotic resistance (MarC)-related H3L99_RS23440 ENOG4105C1J atp-dependent rna helicase H3L99_RS23535 ENOG4105C4R Atp-dependent dna helicase H3L99_RS23565 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H3L99_RS23635 ENOG41063PX domain protein H3L99_RS23645 ENOG4105DJZ UPF0182 protein H3L99_RS23680 ENOG4107TK4 histidinol-phosphate phosphatase H3L99_RS23690 ENOG4105KPY Small multidrug resistance protein H3L99_RS23695 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H3L99_RS23700 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H3L99_RS23710 ENOG4108RAV Conserved protein H3L99_RS23720 ENOG4105EMN RNA polymerase sigma factor H3L99_RS23725 ENOG4105WMN AntiSigma factor H3L99_RS23730 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase H3L99_RS23745 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H3L99_RS23755 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H3L99_RS23760 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H3L99_RS23780 ENOG4105FDP GntR family transcriptional regulator H3L99_RS23800 ENOG4105D17 glycoside hydrolase, family 3 domain protein H3L99_RS23820 ENOG4105CBD Diacylglycerol kinase H3L99_RS23850 ENOG4105K6H D-cysteine desulfhydrase H3L99_RS23855 ENOG4105ESN nucleotide-binding protein H3L99_RS23875 ENOG4105S7M extracellular small neutral protease H3L99_RS23905 ENOG4108VEQ Superoxide dismutase H3L99_RS23910 ENOG4105C3F Signal peptidase i H3L99_RS23920 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H3L99_RS23925 ENOG4105CDA abc transporter atp-binding protein H3L99_RS23930 ENOG4108HW4 amino acid AbC transporter H3L99_RS23950 ENOG4105DGI Alkaline phosphatase H3L99_RS23955 ENOG4105CB2 alcohol dehydrogenase H3L99_RS24005 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H3L99_RS24010 ENOG4105EB3 Histidine kinase H3L99_RS24015 ENOG4108PYU two-component system response regulator H3L99_RS24035 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H3L99_RS24040 ENOG4105DDN Pentapeptide repeat-containing protein H3L99_RS24085 ENOG4105ZXU NLP P60 protein H3L99_RS24120 ENOG4105CJN penicillin-binding protein H3L99_RS24150 ENOG4105DQE DNA ligase H3L99_RS24155 ENOG4105FDF Could be involved in DNA repair (By similarity) H3L99_RS24185 ENOG4105C26 Dehydrogenase H3L99_RS24315 ENOG4105C75 arginyL-tRNA synthetase H3L99_RS24320 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H3L99_RS24325 ENOG4105D6E homoserine dehydrogenase H3L99_RS24330 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) H3L99_RS24335 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) H3L99_RS24345 ENOG4108KGH TRANSCRIPTIONal H3L99_RS24350 ENOG4105VFB Binds the 23S rRNA (By similarity) H3L99_RS24355 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H3L99_RS24360 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H3L99_RS24370 ENOG4107ZF2 Phosphatase H3L99_RS24375 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H3L99_RS24385 ENOG4105Z3P ATP synthase H3L99_RS24395 ENOG4105ZA1 atp synthase H3L99_RS24400 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) H3L99_RS24405 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H3L99_RS24410 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H3L99_RS24415 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H3L99_RS24420 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H3L99_RS24425 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H3L99_RS24440 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS24450 ENOG4105IIP Membrane H3L99_RS24460 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H3L99_RS24470 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H3L99_RS24530 ENOG4105CHU acetyl-coa acetyltransferase H3L99_RS24545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H3L99_RS24550 ENOG4106F60 Histidine kinase H3L99_RS24615 ENOG4105WX6 Membrane H3L99_RS24670 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H3L99_RS24675 ENOG4105C6K Malic enzyme H3L99_RS24680 ENOG4105CTQ phosphohexokinase H3L99_RS24710 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component H3L99_RS24720 ENOG4108MRH transcriptional regulatory protein H3L99_RS24730 ENOG4107QJT sodium dicarboxylate symporter H3L99_RS24740 ENOG4105K63 Thioredoxin H3L99_RS24745 ENOG4108KPJ rna polymerase sigma factor H3L99_RS24755 ENOG4105F44 Two component transcriptional regulator, winged helix family H3L99_RS24770 ENOG4105EEM helicase H3L99_RS24775 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H3L99_RS24790 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) H3L99_RS24795 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H3L99_RS24850 ENOG4105C7N Xanthine uracil vitamin C permease H3L99_RS24855 ENOG4105BZU Histidine kinase H3L99_RS24875 ENOG4105BZ1 (ABC) transporter H3L99_RS24880 ENOG4105BZ1 (ABC) transporter H3L99_RS24885 ENOG4105CJ1 ABC, transporter H3L99_RS24895 ENOG4105BZU Histidine kinase H3L99_RS24900 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS24915 ENOG4107UBC ErfK ybiS ycfS ynhG family protein H3L99_RS24925 ENOG4105CJA serine threonine protein kinase H3L99_RS24970 ENOG4105EJQ L-serine dehydratase H3L99_RS24975 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H3L99_RS24980 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) H3L99_RS24985 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H3L99_RS25005 ENOG4105DEF Extracellular solute-binding protein, family 5 H3L99_RS25010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H3L99_RS25015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS25020 ENOG4105C3U ABC transporter H3L99_RS25025 ENOG4108JQ7 (ABC) transporter H3L99_RS25030 ENOG4105EN6 Membrane H3L99_RS25040 ENOG4105EJ2 Transcriptional regulator H3L99_RS25070 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H3L99_RS25090 ENOG4105EMU Dehydrogenase H3L99_RS25100 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H3L99_RS25105 ENOG4105BZU Histidine kinase H3L99_RS25110 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H3L99_RS25115 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H3L99_RS25125 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H3L99_RS25140 ENOG4105HSS phospholipase C H3L99_RS25145 ENOG4105EYF MMPL domain protein H3L99_RS25150 ENOG4105D9U N-acetyltransferase H3L99_RS25175 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS25190 ENOG4108FN7 Aldo keto reductase H3L99_RS25200 ENOG4105BZU Histidine kinase H3L99_RS25210 ENOG4108ZP8 Acetolactate synthase small subunit H3L99_RS25215 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H3L99_RS25220 ENOG4108JQ1 Dehydrogenase H3L99_RS25235 ENOG4105C57 major facilitator superfamily H3L99_RS25255 ENOG4105C26 Dehydrogenase H3L99_RS25280 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H3L99_RS25285 ENOG4105CM2 brancheD-chain amino acid aminotransferase H3L99_RS25300 ENOG4105CQM Urea amidohydrolase subunit alpha H3L99_RS25305 ENOG4105DWY Agmatine deiminase H3L99_RS25315 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H3L99_RS25325 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS25340 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin H3L99_RS25345 ENOG4108YYC ycei family H3L99_RS25360 ENOG4105ESP cell wall surface anchor family protein H3L99_RS25365 ENOG4105D8K carboxyl transferase H3L99_RS25395 ENOG4105GWZ Roadblock lc7 family protein H3L99_RS25415 ENOG4105GWZ Roadblock lc7 family protein H3L99_RS25430 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H3L99_RS25435 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H3L99_RS25480 ENOG41069M3 Transcriptional regulator H3L99_RS25485 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H3L99_RS25490 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H3L99_RS25500 ENOG4105K70 DNA-binding protein H3L99_RS25520 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H3L99_RS25525 ENOG4105CPF Cell wall formation (By similarity) H3L99_RS25545 ENOG4105DWF phosphomethylpyrimidine kinase H3L99_RS25550 ENOG4105VB9 50S ribosomal protein l28 H3L99_RS25555 ENOG4105DP4 dak2 domain fusion protein ylov H3L99_RS25565 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H3L99_RS25575 ENOG4106H78 methyltransferase H3L99_RS25580 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H3L99_RS25595 ENOG41084BZ 50S ribosomal protein L32 H3L99_RS25600 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H3L99_RS25605 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H3L99_RS25620 ENOG4105K4I Scp-like extracellular H3L99_RS25625 ENOG4108375 Acylphosphatase (EC 3.6.1.7) H3L99_RS25635 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) H3L99_RS25650 ENOG4105ETS cytosine purines uracil thiamine allantoin H3L99_RS25680 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) H3L99_RS25695 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) H3L99_RS25705 ENOG4105K5M 30s ribosomal protein S16 H3L99_RS25710 ENOG41082KU UPF0109 protein H3L99_RS25715 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) H3L99_RS25725 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H3L99_RS25730 ENOG4107QYR Signal peptidase i H3L99_RS25740 ENOG4107QYR Signal peptidase i H3L99_RS25745 ENOG4107QYR Signal peptidase i H3L99_RS25760 ENOG41080R2 UPF0102 protein H3L99_RS25775 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS25790 ENOG4105CE9 30S ribosomal protein S2 H3L99_RS25795 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) H3L99_RS25800 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H3L99_RS25805 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H3L99_RS25810 ENOG4105KNE Phosphatidate cytidylyltransferase H3L99_RS25825 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H3L99_RS25835 ENOG4108I5D sulfate abc transporter H3L99_RS25840 ENOG4108UCS ABC, transporter H3L99_RS25855 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H3L99_RS25860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H3L99_RS25870 ENOG4105C26 Dehydrogenase H3L99_RS25885 ENOG4105FQP Beta-lactamase H3L99_RS25890 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS25895 ENOG4105BZU Histidine kinase H3L99_RS25910 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H3L99_RS25930 ENOG4107RUE extracellular solute-binding protein family 1 H3L99_RS25935 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H3L99_RS25940 ENOG4105F38 ABC transporter, permease H3L99_RS25945 ENOG4105D38 putrescine abc transporter H3L99_RS25950 ENOG4105CJP fad dependent oxidoreductase H3L99_RS25980 ENOG4105G9B Transcriptional regulator H3L99_RS25985 ENOG4105FDR Membrane H3L99_RS25990 ENOG4105C26 Dehydrogenase H3L99_RS26015 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H3L99_RS26020 ENOG4105DZP Membrane-associated zinc metalloprotease H3L99_RS26025 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) H3L99_RS26040 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H3L99_RS26045 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase H3L99_RS26060 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) H3L99_RS26075 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) H3L99_RS26085 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H3L99_RS26090 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H3L99_RS26105 ENOG4105C22 threonyL-tRNA synthetase H3L99_RS26120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS26125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H3L99_RS26155 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin H3L99_RS26175 ENOG4105EC2 ftsk spoIIIe H3L99_RS26185 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H3L99_RS26190 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H3L99_RS26195 ENOG4105C1V Peptidase, M16 H3L99_RS26200 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H3L99_RS26225 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H3L99_RS26230 ENOG4105CN5 Metallo-Beta-Lactamase H3L99_RS26265 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase H3L99_RS26270 ENOG4107QZI cell division protein FtsK H3L99_RS26280 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) H3L99_RS26290 ENOG4105CEV competence damage-inducible protein H3L99_RS26295 ENOG4105WBV Transcriptional regulator H3L99_RS26305 ENOG4105CHR reductase H3L99_RS26310 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) H3L99_RS26315 ENOG4107QRT dEAD DEAH box helicase H3L99_RS26350 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H3L99_RS26360 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) H3L99_RS26395 ENOG4105DRP amino acid AbC transporter H3L99_RS26400 ENOG4108Q1T ABC transporter H3L99_RS26405 ENOG4107UBR Extracellular solute-binding protein family 3 H3L99_RS26410 ENOG4105CDA abc transporter atp-binding protein H3L99_RS26415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H3L99_RS26420 ENOG4105EB3 Histidine kinase H3L99_RS26430 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H3L99_RS26450 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H3L99_RS26460 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H3L99_RS26465 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H3L99_RS26475 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H3L99_RS26515 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) H3L99_RS26520 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) H3L99_RS26525 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H3L99_RS26555 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H3L99_RS26575 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H3L99_RS26590 ENOG4105C9U ATP-dependent DNA helicase RecQ H3L99_RS26610 ENOG4105DRR Transcriptional regulator, GntR family H3L99_RS26615 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H3L99_RS26620 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap H3L99_RS26630 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H3L99_RS26635 ENOG4105BZU Histidine kinase H3L99_RS26640 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS26650 ENOG4107QN1 sodium solute H3L99_RS26655 ENOG4108MRH transcriptional regulatory protein H3L99_RS26660 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H3L99_RS26680 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H3L99_RS26700 ENOG4105DRR Transcriptional regulator, GntR family H3L99_RS26705 ENOG410849S phosphocarrier protein (HPr) H3L99_RS26710 ENOG4105CD5 CoA-binding domain protein H3L99_RS26725 ENOG4107W53 thymidine kinase H3L99_RS26785 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) H3L99_RS26800 ENOG4105F44 Two component transcriptional regulator, winged helix family H3L99_RS26805 ENOG4106F60 Histidine kinase H3L99_RS26830 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H3L99_RS26840 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H3L99_RS26870 ENOG4107VEG TrkA-N domain protein H3L99_RS26875 ENOG4105C0X amino acid H3L99_RS26880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H3L99_RS26890 ENOG4107Y2X deaminase H3L99_RS26930 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H3L99_RS26945 ENOG4105K64 Glycosyl transferase, family 2 H3L99_RS26955 ENOG4105EQQ protein containing aminopeptidase domain H3L99_RS26970 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase H3L99_RS26980 ENOG4105CPK Glycosyl transferase (Group 1 H3L99_RS27000 ENOG4107RRD Dehydrogenase H3L99_RS27005 ENOG4105CAQ asparagine synthetase H3L99_RS27025 ENOG4105C6Y Udp-glucose 6-dehydrogenase H3L99_RS27030 ENOG4105D3Q Sugar transferase H3L99_RS27085 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H3L99_RS27090 ENOG4105CVN desaturase H3L99_RS27130 ENOG4105CGD Nad-dependent epimerase dehydratase H3L99_RS27140 ENOG4105BZP glycoside hydrolase 15-related H3L99_RS27170 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) H3L99_RS27175 ENOG4105VEQ Cold shock protein H3L99_RS27180 ENOG4105C1J atp-dependent rna helicase H3L99_RS27205 ENOG4105F44 Two component transcriptional regulator, winged helix family H3L99_RS27210 ENOG4106F60 Histidine kinase H3L99_RS27225 ENOG4105MHT Transcriptional regulator, ARSR family H3L99_RS27235 ENOG4105E7W lamb ycsf family protein H3L99_RS27240 ENOG4105P4J Allophanate hydrolase, subunit 1 H3L99_RS27260 ENOG4108ZBR Gcn5-related n-acetyltransferase H3L99_RS27275 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H3L99_RS27305 ENOG4105E4C Lytic transglycosylase catalytic H3L99_RS27355 ENOG4108S01 response regulator H3L99_RS27360 ENOG4106M32 3-dehydroquinate synthase H3L99_RS27365 ENOG41061GT Aldolase H3L99_RS27375 ENOG4107STQ Multicopper oxidase H3L99_RS27495 ENOG4105KTE polyketide synthesis cyclase H3L99_RS27505 ENOG41079R3 acyl carrier protein H3L99_RS27510 ENOG4108PDG Beta-ketoacyl synthase H3L99_RS27535 ENOG4107R37 Glutamate dehydrogenase H3L99_RS27545 ENOG4108IAJ Nad-dependent epimerase dehydratase H3L99_RS27560 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H3L99_RS27565 ENOG4105DKP glycosyl transferase, family 9 H3L99_RS27575 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) H3L99_RS27580 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H3L99_RS27585 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) H3L99_RS27590 ENOG4105DKP glycosyl transferase, family 9 H3L99_RS27600 ENOG4108R85 Short chain dehydrogenase H3L99_RS27605 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H3L99_RS27615 ENOG4105E08 Glycoside hydrolase, family 9 H3L99_RS27625 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS27645 ENOG4108U3T pfkb domain protein H3L99_RS27655 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS27660 ENOG4107FKK extracellular solute-binding protein family 1 H3L99_RS27665 ENOG4105D56 permease protein H3L99_RS27675 ENOG4105CG3 alpha amylase, catalytic region H3L99_RS27720 ENOG4107QK5 Homocysteine s-methyltransferase H3L99_RS27730 ENOG4107S1Q Phosphatase H3L99_RS27790 ENOG4105DBV ornithine carbamoyltransferase H3L99_RS27795 ENOG4105CUB amino acid H3L99_RS27805 ENOG4105CGU Enoyl-CoA hydratase H3L99_RS27865 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H3L99_RS27880 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H3L99_RS27900 ENOG4107QM5 aconitate hydratase H3L99_RS27935 ENOG4106HB6 Alpha beta hydrolase H3L99_RS27940 ENOG4105W1N transcriptional regulator H3L99_RS27955 ENOG4105E2R ROK family H3L99_RS27960 ENOG4105DFW ABC transporter H3L99_RS27965 ENOG4105C2J ABC transporter H3L99_RS27970 ENOG4108HWW ABC transporter H3L99_RS27975 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H3L99_RS27980 ENOG4105CUB amino acid H3L99_RS28005 ENOG4105C39 capsular polysaccharide phosphotransferase H3L99_RS28015 ENOG4108I69 Glycosyl transferases group 1 H3L99_RS28030 ENOG4105CHU acetyl-coa acetyltransferase H3L99_RS28040 ENOG4106NZI LysR family Transcriptional regulator H3L99_RS28060 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H3L99_RS28070 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase H3L99_RS28080 ENOG4105C1Q protoporphyrinogen oxidase H3L99_RS28085 ENOG4107JTW chlorite dismutase H3L99_RS28090 ENOG4106JDR secreted H3L99_RS28100 ENOG4105E18 UPF0276 protein H3L99_RS28115 ENOG4105ECQ AraC Family Transcriptional Regulator H3L99_RS28145 ENOG4108IUX (ABC) transporter H3L99_RS28190 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H3L99_RS28200 ENOG4107T3P ABC, transporter H3L99_RS28215 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component H3L99_RS28220 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component H3L99_RS28225 ENOG4105K56 Transcriptional regulator H3L99_RS28230 ENOG4108ZHJ Organic hydroperoxide resistance protein H3L99_RS28265 ENOG4105DFU Cell wall formation (By similarity) H3L99_RS28270 ENOG4105E0X reductase H3L99_RS28280 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS28285 ENOG4105BZU Histidine kinase H3L99_RS28290 ENOG4105CJ1 ABC, transporter H3L99_RS28330 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 H3L99_RS28390 ENOG4105BZU Histidine kinase H3L99_RS28395 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS28435 ENOG4106UDK Cellulose-binding, family II H3L99_RS28440 ENOG4105EGE secreted protein H3L99_RS28450 ENOG4108XNA Gas vesicle H3L99_RS28455 ENOG4107ETC gas vesicle protein H3L99_RS28480 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth H3L99_RS28505 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase H3L99_RS28550 ENOG4105DND Transcriptional regulator H3L99_RS28610 ENOG4107WA4 MmpL domain-containing protein H3L99_RS28625 ENOG4107STQ Multicopper oxidase H3L99_RS28630 ENOG4105MC2 DSBA oxidoreductase H3L99_RS28640 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H3L99_RS28645 ENOG4108IY8 ABC, transporter H3L99_RS28670 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) H3L99_RS28680 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H3L99_RS28690 ENOG4107RR1 TRANSCRIPTIONal H3L99_RS28695 ENOG4105CSU acyl-Coa dehydrogenase H3L99_RS28720 ENOG4105BZU Histidine kinase H3L99_RS28725 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H3L99_RS28730 ENOG4105KVH Transcriptional regulator H3L99_RS28735 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H3L99_RS28740 ENOG4105E2A Dehydrogenase H3L99_RS28765 ENOG4107EXU Short-chain dehydrogenase reductase Sdr H3L99_RS28805 ENOG4108C33 Resolvase H3L99_RS28835 ENOG4105DCG PHP domain protein H3L99_RS28845 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H3L99_RS28870 ENOG4105C7K acetolactate synthase H3L99_RS28890 ENOG4105DRR Transcriptional regulator, GntR family H3L99_RS28925 ENOG4108U1V ABC transporter, permease H3L99_RS28930 ENOG4105DQ5 transport system permease protein H3L99_RS28935 ENOG4105E0A ABC, transporter H3L99_RS28965 ENOG4105BZ1 (ABC) transporter H3L99_RS28985 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding H3L99_RS28990 ENOG4105C7N Xanthine uracil vitamin C permease H3L99_RS29050 ENOG4105CSR polyphosphate kinase 2 H3L99_RS29065 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H3L99_RS29070 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS29085 ENOG41060W2 glyoxylate carboligase H3L99_RS29095 ENOG4105CH6 catalase H3L99_RS29100 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H3L99_RS29105 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H3L99_RS29155 ENOG4105CY3 ABC transporter, permease H3L99_RS29195 ENOG4105VT2 5-hydroxyisourate hydrolase H3L99_RS29205 ENOG4105C2W permease H3L99_RS29210 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) H3L99_RS29225 ENOG4105CPQ Dehydrogenase H3L99_RS29230 ENOG4108K8S endonuclease I H3L99_RS29260 ENOG4105DYS nad(p)h dehydrogenase (quinone) H3L99_RS29310 ENOG4105EBR Carboxylesterase H3L99_RS29315 ENOG4105JAB phenazine biosynthesis protein, phzf family H3L99_RS29320 ENOG4105DBA pectate lyase H3L99_RS29335 ENOG4105ETX regulatoR H3L99_RS29340 ENOG41065SU Two-component system sensor kinase H3L99_RS29345 ENOG4108762 serine threonine protein kinase H3L99_RS29350 ENOG4105K4I Scp-like extracellular H3L99_RS29380 ENOG4105CHR reductase H3L99_RS29390 ENOG4108MJI response regulator H3L99_RS29405 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H3L99_RS29430 ENOG41061H0 Monooxygenase H3L99_RS29470 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 H3L99_RS29495 ENOG4105C02 permease H3L99_RS29515 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) H3L99_RS29540 ENOG4105E6M Sulphatase-modifying factor protein H3L99_RS29555 ENOG4105GMT ATPase associated with various cellular activities aaa_5 H3L99_RS29565 ENOG4105CSH Transporter H3L99_RS29610 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) H3L99_RS29695 ENOG4105KVH Transcriptional regulator H3L99_RS29705 ENOG4105DV0 amidase (EC 3.5.1.4 H3L99_RS29710 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H3L99_RS29720 ENOG4105KVH Transcriptional regulator H3L99_RS29730 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) H3L99_RS29745 ENOG4107R9S Malate synthase H3L99_RS29770 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS29775 ENOG4105ENE Histidine kinase H3L99_RS29795 ENOG4107HP6 Transcriptional regulator H3L99_RS29805 ENOG4105DHG Allantoate amidinohydrolase H3L99_RS29810 ENOG4105F6U Short-chain dehydrogenase reductase Sdr H3L99_RS29840 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS29860 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) H3L99_RS29870 ENOG4105D4B ABC, transporter H3L99_RS29880 ENOG4105CNN ABC, transporter H3L99_RS29885 ENOG4105C2J ABC transporter H3L99_RS29940 ENOG4105DR5 peptidase H3L99_RS29955 ENOG4105F0K SARP family transcriptional regulator H3L99_RS30035 ENOG4105BZ1 (ABC) transporter H3L99_RS30060 ENOG4105CDA abc transporter atp-binding protein H3L99_RS30075 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H3L99_RS30105 ENOG4105C8Y Acetylornithine aminotransferase H3L99_RS30110 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) H3L99_RS30120 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease H3L99_RS30130 ENOG4108RG3 short-chain dehydrogenase reductase H3L99_RS30155 ENOG4105BZU Histidine kinase H3L99_RS30160 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS30170 ENOG41067TZ transcriptional regulator, MarR family H3L99_RS30180 ENOG4105C84 Histidine ammonia-lyase H3L99_RS30190 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H3L99_RS30195 ENOG4105ECY inositol monophosphatase H3L99_RS30215 ENOG4108UVJ appr-1-p processing domain protein H3L99_RS30225 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H3L99_RS30230 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H3L99_RS30240 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H3L99_RS30250 ENOG4108IV0 ABC, transporter H3L99_RS30255 ENOG4105C0Z ABC transporter H3L99_RS30260 ENOG4105C32 Amino acid ABC transporter (Permease) H3L99_RS30285 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme H3L99_RS30290 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS30320 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H3L99_RS30330 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 H3L99_RS30340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H3L99_RS30345 ENOG4107B2H carbonic anhydrase H3L99_RS30350 ENOG4105CHH sulfate transporter H3L99_RS30380 ENOG4108Q50 Histidine kinase H3L99_RS30420 ENOG4105CIK Amidinotransferase H3L99_RS30425 ENOG4105C8Y Acetylornithine aminotransferase H3L99_RS30430 ENOG4108ME1 Peptidase M55 D-aminopeptidase H3L99_RS30435 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H3L99_RS30440 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein H3L99_RS30445 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H3L99_RS30450 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H3L99_RS30475 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H3L99_RS30500 ENOG4105E8R UPF0173 metal-dependent hydrolase H3L99_RS30510 ENOG4105D5Q Arginine ornithine antiporter H3L99_RS30550 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) H3L99_RS30560 ENOG410842T Pterin carbinolamine dehydratase H3L99_RS30585 ENOG4105CV8 reductase H3L99_RS30625 ENOG4105DHU Bile acid H3L99_RS30650 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H3L99_RS30655 ENOG4107QHI -hydrogenase H3L99_RS30665 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H3L99_RS30670 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H3L99_RS30675 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H3L99_RS30700 ENOG4105DKQ ROK family H3L99_RS30705 ENOG4105C2J ABC transporter H3L99_RS30710 ENOG4105CNN ABC, transporter H3L99_RS30715 ENOG4105DFW ABC transporter H3L99_RS30780 ENOG4108Z6Z Transcriptional regulator H3L99_RS30790 ENOG4105FCD Major Facilitator H3L99_RS30810 ENOG4105CMV Succinyl-CoA synthetase subunit beta H3L99_RS30820 ENOG4105C26 Dehydrogenase H3L99_RS30855 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS30860 ENOG4105C2J ABC transporter H3L99_RS30865 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H3L99_RS30870 ENOG4108RVA ribokinase H3L99_RS30875 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) H3L99_RS30895 ENOG4105ECQ AraC Family Transcriptional Regulator H3L99_RS30945 ENOG4108DN8 FAD dependent oxidoreductase H3L99_RS30955 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein H3L99_RS30965 ENOG4105CTU Proline racemase H3L99_RS30975 ENOG4108KPJ rna polymerase sigma factor H3L99_RS31005 ENOG4105CX8 fg-gap repeat protein H3L99_RS31080 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H3L99_RS31200 ENOG4108762 serine threonine protein kinase H3L99_RS31230 ENOG4105VUF Transcriptional regulator H3L99_RS31265 ENOG4108KSA LysR family transcriptional regulator H3L99_RS31275 ENOG4107ZR7 Membrane H3L99_RS31305 ENOG4105CSH Transporter H3L99_RS31310 ENOG4105CHU acetyl-coa acetyltransferase H3L99_RS31320 ENOG4107RSM transcriptional regulator H3L99_RS31335 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H3L99_RS31410 ENOG4108IMY Transcriptional regulator H3L99_RS31450 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) H3L99_RS31455 ENOG4105CSH Transporter H3L99_RS31475 ENOG4108YYH Nadph-dependent fmn reductase H3L99_RS31505 ENOG4105F8D glycoside hydrolase family 4 H3L99_RS31515 ENOG4105K5B UPF0225 protein H3L99_RS31615 ENOG4105DQE DNA ligase H3L99_RS31640 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H3L99_RS31650 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H3L99_RS31685 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H3L99_RS31695 ENOG4108KQ5 Integrase catalytic subunit H3L99_RS31705 ENOG4105C5H ABC transporter H3L99_RS31735 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) H3L99_RS31745 ENOG4105EG6 Saccharopine dehydrogenase H3L99_RS31755 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS31760 ENOG4105CHU acetyl-coa acetyltransferase H3L99_RS31765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H3L99_RS31820 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component H3L99_RS31850 ENOG4105C94 Transporter H3L99_RS31875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS31880 ENOG4105C3U ABC transporter H3L99_RS31885 ENOG4108JQ7 (ABC) transporter H3L99_RS31910 ENOG4105BZM domain protein H3L99_RS31940 ENOG4105E39 Enoyl-CoA hydratase H3L99_RS31955 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) H3L99_RS31960 ENOG4107QVI Methyltransferase, type 11 H3L99_RS31985 ENOG4108MDK Dehydrogenase H3L99_RS32005 ENOG4105EY8 ABC transporter H3L99_RS32010 ENOG4105FBD synthase H3L99_RS32020 ENOG4107S11 squalene-associated FAD-dependent desaturase H3L99_RS32030 ENOG4105EWU Squalene--hopene cyclase H3L99_RS32075 ENOG41090WU lipolytic protein G-D-S-L family H3L99_RS32085 ENOG4105D4P Coproporphyrinogen iii oxidase H3L99_RS32120 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H3L99_RS32160 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component H3L99_RS32170 ENOG4108IY8 ABC, transporter H3L99_RS32225 ENOG4105NAE bifunctional deaminase-reductase domain protein H3L99_RS32260 ENOG4108MES Periplasmic binding protein H3L99_RS32285 ENOG4105DQ5 transport system permease protein H3L99_RS32290 ENOG4105TVJ transport system, permease H3L99_RS32295 ENOG4105E0A ABC, transporter H3L99_RS32315 ENOG4105E82 cytochrome subunit of dehydrogenase H3L99_RS32340 ENOG4105CSA Coproporphyrinogen iii oxidase H3L99_RS32400 ENOG4105CMG Carbohydrate kinase H3L99_RS32415 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component H3L99_RS32420 ENOG4105DRS transport system, permease H3L99_RS32435 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS32445 ENOG4105E6M Sulphatase-modifying factor protein H3L99_RS32470 ENOG4105JQN Transcriptional regulator H3L99_RS32530 ENOG4107RP9 extracellular solute-binding protein, family 3 H3L99_RS32545 ENOG4105CYP glycoside hydrolase, family H3L99_RS32550 ENOG41065HY 1,4-beta-cellobiosidase H3L99_RS32560 ENOG4105NAF rna polymerase sigma factor H3L99_RS32580 ENOG4108J20 pectate lyase H3L99_RS32585 ENOG4107TDE lipolytic protein G-D-S-L family H3L99_RS32590 ENOG4105XN3 extracellular solute-binding protein family 1 H3L99_RS32595 ENOG4105E4I Glycoside hydrolase family 28 H3L99_RS32615 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component H3L99_RS32630 ENOG4105DRR Transcriptional regulator, GntR family H3L99_RS32645 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H3L99_RS32690 ENOG4105CSU acyl-Coa dehydrogenase H3L99_RS32705 ENOG4105NAE bifunctional deaminase-reductase domain protein H3L99_RS32710 ENOG4108V1U phospholipid-binding protein H3L99_RS32725 ENOG41086D8 Transcriptional regulator H3L99_RS32730 ENOG4107QK4 glycoside hydrolase, family 3 domain protein H3L99_RS32735 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS32770 ENOG4108KPJ rna polymerase sigma factor H3L99_RS32805 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) H3L99_RS32845 ENOG4105KVH Transcriptional regulator H3L99_RS32865 ENOG4105VMP Transcriptional regulator H3L99_RS32880 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) H3L99_RS32900 ENOG4105DCG PHP domain protein H3L99_RS32910 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H3L99_RS32920 ENOG4105DJB Major Facilitator Superfamily H3L99_RS32925 ENOG4105E2B Taurine dioxygenase H3L99_RS32930 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H3L99_RS32935 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme H3L99_RS32945 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS32950 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H3L99_RS32965 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H3L99_RS32985 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component H3L99_RS32990 ENOG4105CPQ Dehydrogenase H3L99_RS33055 ENOG4105DQE DNA ligase H3L99_RS33080 ENOG4108NEV two component transcriptional regulator, LytTR family H3L99_RS33165 ENOG4105BZU Histidine kinase H3L99_RS33170 ENOG4105C5Q Transcriptional regulator H3L99_RS33185 ENOG4105E33 succinate dehydrogenase H3L99_RS33190 ENOG4105E8R UPF0173 metal-dependent hydrolase H3L99_RS33205 ENOG4105DEN Luciferase family H3L99_RS33215 ENOG4105WKW Pfam:DUF1458 H3L99_RS33220 ENOG4105FDP GntR family transcriptional regulator H3L99_RS33225 ENOG4105EYF MMPL domain protein H3L99_RS33235 ENOG4105WH1 Two component transcriptional regulator luxr family H3L99_RS33240 ENOG4105BZU Histidine kinase H3L99_RS33255 ENOG4105FDP GntR family transcriptional regulator H3L99_RS33275 ENOG4105E2D ec 3.2.1.52 H3L99_RS33280 ENOG4105CYP glycoside hydrolase, family H3L99_RS33300 ENOG41067HS methyltransferase H3L99_RS33305 ENOG4108V75 Glutamine amidotransferase H3L99_RS33310 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process H3L99_RS33335 ENOG41080RH Thioredoxin H3L99_RS33340 ENOG4107QN2 dihydrolipoyl dehydrogenase H3L99_RS33355 ENOG4105EUB pirin domain protein H3L99_RS33410 ENOG4107S8A protein TIM barrel H3L99_RS33415 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H3L99_RS33425 ENOG4105FB2 class II Aldolase H3L99_RS33465 ENOG4105EMN RNA polymerase sigma factor H3L99_RS33470 ENOG4105BZP glycoside hydrolase 15-related H3L99_RS33570 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase H3L99_RS33575 ENOG4105NPE arsR family transcriptional regulator H3L99_RS33580 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H3L99_RS33585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS33605 ENOG4105CKI cobalamin synthesis protein H3L99_RS33610 ENOG4105KME endoribonuclease L-psp H3L99_RS33660 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase H3L99_RS33670 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) H3L99_RS33685 ENOG4108UW5 maltose o-acetyltransferase H3L99_RS33690 ENOG4108RFG Tetr family transcriptional regulator H3L99_RS33695 ENOG4105D7N magnesium and cobalt transport protein CorA H3L99_RS33740 ENOG4106NZI LysR family Transcriptional regulator H3L99_RS33795 ENOG4105KVH Transcriptional regulator H3L99_RS33835 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H3L99_RS33875 ENOG41068HZ 50S ribosomal protein L32 H3L99_RS33885 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H3L99_RS33890 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H3L99_RS33950 ENOG4105CHR reductase H3L99_RS33965 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H3L99_RS33975 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) H3L99_RS34000 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component H3L99_RS34005 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component H3L99_RS34010 ENOG4105CG3 alpha amylase, catalytic region H3L99_RS34020 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component H3L99_RS34035 ENOG4105E2R ROK family H3L99_RS34095 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS34110 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H3L99_RS34115 ENOG4105C2J ABC transporter H3L99_RS34120 ENOG4107R9N ABC transporter H3L99_RS34125 ENOG4105CNN ABC, transporter H3L99_RS34135 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H3L99_RS34165 ENOG4105EPH radical SAM domain protein H3L99_RS34170 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H3L99_RS34180 ENOG4105KVH Transcriptional regulator H3L99_RS34200 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS34215 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component H3L99_RS34225 ENOG4105BZ1 (ABC) transporter H3L99_RS34245 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H3L99_RS34275 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein H3L99_RS34285 ENOG4105ECP epimerase H3L99_RS34300 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) H3L99_RS34320 ENOG4107SGM protein serine threonine phosphatase H3L99_RS34340 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H3L99_RS34350 ENOG4107FW0 short-chain dehydrogenase reductase H3L99_RS34355 ENOG4105DGI Alkaline phosphatase H3L99_RS34375 ENOG4105J7D transcriptional regulator H3L99_RS34385 ENOG4105CH2 amidohydrolase H3L99_RS34395 ENOG4105EPC oxidoreductase H3L99_RS34405 ENOG4105E98 transcriptional regulator DeoR family H3L99_RS34410 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H3L99_RS34420 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H3L99_RS34430 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) H3L99_RS34440 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H3L99_RS34450 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS34455 ENOG4108JQ1 Dehydrogenase H3L99_RS34485 ENOG4107QM2 Aldo Keto reductase H3L99_RS34510 ENOG4105I82 acetyl xylan esterase H3L99_RS34515 ENOG4107SMB hydrolase Family 5 H3L99_RS34535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H3L99_RS34540 ENOG4105D2B acyl-CoA dehydrogenase H3L99_RS34545 ENOG4105D2B acyl-CoA dehydrogenase H3L99_RS34560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H3L99_RS34570 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) H3L99_RS34630 ENOG4105BZU Histidine kinase H3L99_RS34660 ENOG4105GWZ Roadblock lc7 family protein H3L99_RS34670 ENOG4105CPQ Dehydrogenase H3L99_RS34675 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H3L99_RS34680 ENOG4107NQ8 LysR family Transcriptional regulator H3L99_RS34710 ENOG4105F27 Major Facilitator H3L99_RS34720 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H3L99_RS34730 ENOG4105CT1 (ABC) transporter H3L99_RS34735 ENOG4105EAD ABC transporter H3L99_RS34775 ENOG4105J7D transcriptional regulator H3L99_RS34840 ENOG4105DXX methyltransferase H3L99_RS34875 ENOG4105CQM Urea amidohydrolase subunit alpha H3L99_RS34890 ENOG4108W5X Transcriptional Regulator, LuxR family H3L99_RS34900 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H3L99_RS34915 ENOG4108RZE Tetr family transcriptional regulator H3L99_RS34930 ENOG4105CHU acetyl-coa acetyltransferase H3L99_RS34935 ENOG410900P UPF0336 protein H3L99_RS34950 ENOG4105CEY Amp-dependent synthetase and ligase H3L99_RS34955 ENOG4105C1G acyl-Coa dehydrogenase H3L99_RS34960 ENOG4108R85 Short chain dehydrogenase H3L99_RS34970 ENOG4105XEA Tetr family transcriptional regulator H3L99_RS34990 ENOG4105D8K carboxyl transferase H3L99_RS35005 ENOG4108JIK carboxylase H3L99_RS35040 ENOG4108BAS reductase H3L99_RS35050 ENOG4108JGH Tetr family transcriptional regulator H3L99_RS35065 ENOG4105CKK Glycosyl transferase, family 2 H3L99_RS35080 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS35085 ENOG4105EGE secreted protein H3L99_RS35100 ENOG4106T9R serine protease H3L99_RS35110 ENOG4105ETE Transcriptional regulator (LacI family H3L99_RS35115 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H3L99_RS35150 ENOG4105CXN decarboxylase H3L99_RS35160 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H3L99_RS35185 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily H3L99_RS35255 ENOG4105CPC Aldo Keto reductase H3L99_RS35260 ENOG4105CUB amino acid H3L99_RS35280 ENOG4105CN5 Metallo-Beta-Lactamase H3L99_RS35305 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H3L99_RS35335 ENOG41064MX Tetr family transcriptional regulator