locus-tag	class	description
H3L99_RS00065	COG0420	3'-5' exonuclease activity
H3L99_RS00070	COG0419	ATPase involved in DNA repair
H3L99_RS00165	COG0419	ATPase involved in DNA repair
H3L99_RS00170	COG0420	3'-5' exonuclease activity
H3L99_RS00240	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H3L99_RS00310	COG2318	DinB family
H3L99_RS00335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3L99_RS00360	COG0395	ABC-type sugar transport system, permease component
H3L99_RS00395	COG1278	Cold shock
H3L99_RS00430	COG0789	Transcriptional regulator
H3L99_RS00445	COG1695	Transcriptional regulator
H3L99_RS00460	COG1309	transcriptional regulator
H3L99_RS00540	COG4941	Belongs to the sigma-70 factor family
H3L99_RS00545	COG3795	YCII-related domain
H3L99_RS00550	COG2207	Transcriptional regulator
H3L99_RS00555	COG2223	nitrite transmembrane transporter activity
H3L99_RS00570	COG0513	Belongs to the DEAD box helicase family
H3L99_RS00595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H3L99_RS00610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H3L99_RS00635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3L99_RS00695	COG0110	maltose O-acetyltransferase activity
H3L99_RS00710	COG2132	Multicopper oxidase
H3L99_RS00735	COG0134	indole-3-glycerol-phosphate synthase activity
H3L99_RS00745	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS00750	COG0662	Cupin 2, conserved barrel domain protein
H3L99_RS00755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H3L99_RS00770	COG2030	dehydratase
H3L99_RS00780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L99_RS00785	COG0156	8-amino-7-oxononanoate synthase activity
H3L99_RS00800	COG2072	flavoprotein involved in K transport
H3L99_RS00815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3L99_RS00830	COG0596	Alpha beta hydrolase
H3L99_RS00885	COG1410	methionine synthase
H3L99_RS00885	COG0646	methionine synthase
H3L99_RS00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3L99_RS00895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H3L99_RS00925	COG3251	PFAM MbtH domain protein
H3L99_RS00955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3L99_RS00960	COG2197	response regulator
H3L99_RS01000	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS01040	COG3265	gluconokinase activity
H3L99_RS01060	COG2706	6-phosphogluconolactonase activity
H3L99_RS01075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3L99_RS01085	COG1063	alcohol dehydrogenase
H3L99_RS01100	COG0135	phosphoribosylanthranilate isomerase activity
H3L99_RS01110	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS01115	COG0662	Cupin 2, conserved barrel domain protein
H3L99_RS01120	COG0159	tryptophan synthase activity
H3L99_RS01135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3L99_RS01180	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H3L99_RS01205	COG1024	Enoyl-CoA hydratase
H3L99_RS01215	COG3425	synthase
H3L99_RS01220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3L99_RS01295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3L99_RS01305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3L99_RS01320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L99_RS01340	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS01375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L99_RS01420	COG3629	intracellular signal transduction
H3L99_RS01445	COG4221	oxidoreductase activity
H3L99_RS01445	COG3321	synthase
H3L99_RS01445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3L99_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS01450	COG1024	Enoyl-CoA hydratase
H3L99_RS01460	COG3425	synthase
H3L99_RS01465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L99_RS01470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3L99_RS01475	COG3321	synthase
H3L99_RS01475	COG0300	oxidoreductase activity
H3L99_RS01475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3L99_RS01475	COG4221	oxidoreductase activity
H3L99_RS01485	COG3321	synthase
H3L99_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS01485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3L99_RS01485	COG0300	oxidoreductase activity
H3L99_RS01485	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS01540	COG0022	dehydrogenase e1 component
H3L99_RS01550	COG2890	protein-(glutamine-N5) methyltransferase activity
H3L99_RS01555	COG1605	Chorismate mutase
H3L99_RS01560	COG0287	Prephenate dehydrogenase
H3L99_RS01565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H3L99_RS01565	COG0512	Glutamine amidotransferase of anthranilate synthase
H3L99_RS01570	COG2124	cytochrome p450
H3L99_RS01575	COG2423	ornithine cyclodeaminase activity
H3L99_RS01580	COG1021	2,3-dihydroxybenzoate-AMP ligase
H3L99_RS01585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H3L99_RS01595	COG0477	Major facilitator Superfamily
H3L99_RS01600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3L99_RS01715	COG3447	MASE1 domain protein
H3L99_RS01715	COG5002	protein histidine kinase activity
H3L99_RS01715	COG5001	Diguanylate cyclase
H3L99_RS01720	COG5002	protein histidine kinase activity
H3L99_RS01720	COG2205	protein histidine kinase activity
H3L99_RS01720	COG0784	Response regulator, receiver
H3L99_RS01740	COG1191	sigma factor activity
H3L99_RS01770	COG1309	transcriptional regulator
H3L99_RS01875	COG1573	uracil-dna glycosylase
H3L99_RS01900	COG3290	protein histidine kinase activity
H3L99_RS01995	COG1024	Enoyl-CoA hydratase
H3L99_RS02005	COG0483	inositol monophosphate 1-phosphatase activity
H3L99_RS02040	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS02065	COG0387	Pfam Sodium calcium exchanger
H3L99_RS02095	COG2226	methyltransferase
H3L99_RS02105	COG2070	2-Nitropropane dioxygenase
H3L99_RS02110	COG0515	serine threonine protein kinase
H3L99_RS02110	COG2815	serine threonine protein kinase
H3L99_RS02115	COG0667	Aldo Keto reductase
H3L99_RS02130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H3L99_RS02140	COG0515	serine threonine protein kinase
H3L99_RS02145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H3L99_RS02150	COG1937	Protein conserved in bacteria
H3L99_RS02155	COG0730	response to heat
H3L99_RS02170	COG3548	integral membrane protein
H3L99_RS02190	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS02200	COG1024	Enoyl-CoA hydratase
H3L99_RS02230	COG3958	Transketolase
H3L99_RS02260	COG0517	IMP dehydrogenase activity
H3L99_RS02265	COG0693	protein deglycase activity
H3L99_RS02310	COG2205	protein histidine kinase activity
H3L99_RS02310	COG0784	Response regulator, receiver
H3L99_RS02320	COG1191	sigma factor activity
H3L99_RS02365	COG2124	cytochrome p450
H3L99_RS02390	COG2890	protein-(glutamine-N5) methyltransferase activity
H3L99_RS02445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3L99_RS02460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3L99_RS02465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3L99_RS02475	COG1105	Belongs to the carbohydrate kinase PfkB family
H3L99_RS02480	COG1349	DNA-binding transcription factor activity
H3L99_RS02485	COG0726	polysaccharide deacetylase
H3L99_RS02495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H3L99_RS02510	COG0243	molybdopterin cofactor binding
H3L99_RS02515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H3L99_RS02550	COG2084	Dehydrogenase
H3L99_RS02570	COG0009	L-threonylcarbamoyladenylate synthase
H3L99_RS02575	COG0783	Belongs to the Dps family
H3L99_RS02595	COG0747	negative chemotaxis
H3L99_RS02635	COG0741	lytic transglycosylase activity
H3L99_RS02635	COG0739	heme binding
H3L99_RS02635	COG1196	nuclear chromosome segregation
H3L99_RS02690	COG2376	Dihydroxyacetone kinase
H3L99_RS02695	COG1461	Dihydroxyacetone kinase
H3L99_RS02700	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H3L99_RS02705	COG0310	cobalt ion transport
H3L99_RS02710	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
H3L99_RS02720	COG1122	ATPase activity
H3L99_RS02740	COG2132	Multicopper oxidase
H3L99_RS02775	COG2936	dipeptidyl-peptidase activity
H3L99_RS02780	COG4552	Acetyltransferase involved in intracellular survival and related
H3L99_RS02790	COG2217	Heavy metal translocating P-type atpase
H3L99_RS02795	COG0640	Transcriptional regulator
H3L99_RS02825	COG1295	ribonuclease BN
H3L99_RS02905	COG2124	cytochrome p450
H3L99_RS02945	COG2318	DinB family
H3L99_RS02955	COG1733	regulation of RNA biosynthetic process
H3L99_RS02970	COG2045	Belongs to the ComB family
H3L99_RS03025	COG0395	ABC-type sugar transport system, permease component
H3L99_RS03030	COG4209	transmembrane transport
H3L99_RS03035	COG1653	transport
H3L99_RS03090	COG1595	DNA-templated transcription, initiation
H3L99_RS03100	COG0363	glucosamine-6-phosphate deaminase activity
H3L99_RS03140	COG1222	aaa ATPase
H3L99_RS03265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3L99_RS03285	COG1597	lipid kinase activity
H3L99_RS03290	COG3387	PFAM Glycoside hydrolase 15-related
H3L99_RS03295	COG0477	Major facilitator Superfamily
H3L99_RS03315	COG0842	Transport permease protein
H3L99_RS03315	COG1131	(ABC) transporter
H3L99_RS03315	COG1716	ATPase activity
H3L99_RS03380	COG0395	ABC-type sugar transport system, permease component
H3L99_RS03385	COG1175	transmembrane transport
H3L99_RS03400	COG0667	Aldo Keto reductase
H3L99_RS03405	COG4585	Histidine kinase
H3L99_RS03410	COG2197	response regulator
H3L99_RS03440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3L99_RS03440	COG0723	plastoquinol--plastocyanin reductase activity
H3L99_RS03445	COG2080	2 iron, 2 sulfur cluster binding
H3L99_RS03450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H3L99_RS03455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H3L99_RS03520	COG1472	Belongs to the glycosyl hydrolase 3 family
H3L99_RS03530	COG1175	transmembrane transport
H3L99_RS03540	COG1609	Transcriptional regulator
H3L99_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS03595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H3L99_RS03600	COG0028	Belongs to the TPP enzyme family
H3L99_RS03605	COG0655	NAD(P)H dehydrogenase (quinone) activity
H3L99_RS03615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H3L99_RS03630	COG5297	Belongs to the glycosyl hydrolase family 6
H3L99_RS03630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H3L99_RS03685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L99_RS03695	COG2838	Isocitrate dehydrogenase
H3L99_RS03705	COG2197	response regulator
H3L99_RS03740	COG0659	secondary active sulfate transmembrane transporter activity
H3L99_RS03750	COG1686	Belongs to the peptidase S11 family
H3L99_RS03760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3L99_RS03785	COG3507	Belongs to the glycosyl hydrolase 43 family
H3L99_RS03790	COG0395	ABC-type sugar transport system, permease component
H3L99_RS03795	COG1175	transmembrane transport
H3L99_RS03815	COG3386	PFAM SMP-30 Gluconolaconase
H3L99_RS03820	COG1414	Transcriptional regulator
H3L99_RS03830	COG4213	ABC transporter substrate-binding protein
H3L99_RS03835	COG1129	ABC transporter
H3L99_RS03840	COG4214	carbohydrate transport
H3L99_RS03855	COG0673	inositol 2-dehydrogenase activity
H3L99_RS03875	COG0395	ABC-type sugar transport system, permease component
H3L99_RS03880	COG1175	transmembrane transport
H3L99_RS03915	COG0395	ABC-type sugar transport system, permease component
H3L99_RS03945	COG1846	Transcriptional regulator
H3L99_RS03955	COG2814	Major facilitator Superfamily
H3L99_RS03965	COG0346	lactoylglutathione lyase activity
H3L99_RS03975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H3L99_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS04025	COG1454	alcohol dehydrogenase
H3L99_RS04055	COG0435	Glutathione S-transferase
H3L99_RS04065	COG1672	PFAM Archaeal ATPase
H3L99_RS04065	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H3L99_RS04070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3L99_RS04080	COG1063	alcohol dehydrogenase
H3L99_RS04105	COG0667	Aldo Keto reductase
H3L99_RS04115	COG2072	flavoprotein involved in K transport
H3L99_RS04120	COG0798	PFAM Bile acid sodium symporter
H3L99_RS04125	COG0640	Transcriptional regulator
H3L99_RS04130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H3L99_RS04155	COG1595	DNA-templated transcription, initiation
H3L99_RS04170	COG0640	Transcriptional regulator
H3L99_RS04185	COG2318	DinB family
H3L99_RS04205	COG1609	Transcriptional regulator
H3L99_RS04230	COG1621	beta-fructofuranosidase activity
H3L99_RS04245	COG0187	DNA topoisomerase II activity
H3L99_RS04255	COG1556	Lactate utilization protein
H3L99_RS04260	COG1139	Iron-sulfur cluster binding protein
H3L99_RS04265	COG0247	lactate metabolic process
H3L99_RS04270	COG2186	Transcriptional regulator
H3L99_RS04275	COG1070	Carbohydrate kinase
H3L99_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS04280	COG3347	Dehydrogenase
H3L99_RS04290	COG1129	ABC transporter
H3L99_RS04295	COG1172	Belongs to the binding-protein-dependent transport system permease family
H3L99_RS04310	COG3254	rhamnose metabolic process
H3L99_RS04315	COG1609	Transcriptional regulator
H3L99_RS04320	COG3250	beta-galactosidase activity
H3L99_RS04355	COG0302	gtp cyclohydrolase
H3L99_RS04360	COG0488	(ABC) transporter
H3L99_RS04365	COG0488	(ABC) transporter
H3L99_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS04460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H3L99_RS04485	COG0464	growth
H3L99_RS04495	COG1349	DNA-binding transcription factor activity
H3L99_RS04525	COG0577	efflux transmembrane transporter activity
H3L99_RS04530	COG1136	(ABC) transporter
H3L99_RS04555	COG1940	carbohydrate kinase activity
H3L99_RS04560	COG2223	nitrite transmembrane transporter activity
H3L99_RS04580	COG2197	response regulator
H3L99_RS04585	COG4585	Histidine kinase
H3L99_RS04600	COG0644	oxidoreductase
H3L99_RS04605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3L99_RS04615	COG1660	Displays ATPase and GTPase activities
H3L99_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS04655	COG2409	Drug exporters of the RND superfamily
H3L99_RS04660	COG1846	Transcriptional regulator
H3L99_RS04675	COG0395	ABC-type sugar transport system, permease component
H3L99_RS04680	COG1175	transmembrane transport
H3L99_RS04705	COG0515	serine threonine protein kinase
H3L99_RS04715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H3L99_RS04735	COG0204	Acyl-transferase
H3L99_RS04765	COG0584	glycerophosphoryl diester phosphodiesterase
H3L99_RS04785	COG0671	phosphoesterase, PA-phosphatase related
H3L99_RS04795	COG1309	transcriptional regulator
H3L99_RS04815	COG0640	Transcriptional regulator
H3L99_RS04820	COG1902	pentaerythritol trinitrate reductase activity
H3L99_RS04835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H3L99_RS04840	COG2971	BadF BadG BcrA BcrD
H3L99_RS04850	COG2706	6-phosphogluconolactonase activity
H3L99_RS04905	COG0500	methyltransferase
H3L99_RS04910	COG4981	capsule polysaccharide biosynthetic process
H3L99_RS04930	COG2835	tetraacyldisaccharide 4'-kinase activity
H3L99_RS04940	COG0596	Alpha beta hydrolase
H3L99_RS04965	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H3L99_RS04985	COG2072	flavoprotein involved in K transport
H3L99_RS04990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H3L99_RS04995	COG1132	(ABC) transporter
H3L99_RS05005	COG1132	(ABC) transporter
H3L99_RS05010	COG1132	(ABC) transporter
H3L99_RS05025	COG1946	Acyl-CoA thioesterase
H3L99_RS05040	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS05050	COG0242	peptide deformylase activity
H3L99_RS05060	COG3442	glutamine amidotransferase
H3L99_RS05065	COG0205	6-phosphofructokinase activity
H3L99_RS05095	COG0444	Belongs to the ABC transporter superfamily
H3L99_RS05105	COG0747	negative chemotaxis
H3L99_RS05135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3L99_RS05145	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H3L99_RS05170	COG1957	nucleoside hydrolase
H3L99_RS05195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3L99_RS05200	COG0204	Acyl-transferase
H3L99_RS05210	COG0829	nickel cation binding
H3L99_RS05215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H3L99_RS05220	COG0830	nickel cation binding
H3L99_RS05225	COG0804	urea catabolic process
H3L99_RS05230	COG0832	Belongs to the urease beta subunit family
H3L99_RS05235	COG0831	urea catabolic process
H3L99_RS05240	COG1309	transcriptional regulator
H3L99_RS05255	COG0740	serine-type endopeptidase activity
H3L99_RS05265	COG0791	NLP P60 protein
H3L99_RS05280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H3L99_RS05285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H3L99_RS05290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H3L99_RS05345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H3L99_RS05355	COG3397	chitin binding
H3L99_RS05370	COG1940	carbohydrate kinase activity
H3L99_RS05375	COG2188	Transcriptional regulator
H3L99_RS05380	COG1595	DNA-templated transcription, initiation
H3L99_RS05405	COG0626	cystathionine gamma-synthase activity
H3L99_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS05435	COG1522	sequence-specific DNA binding
H3L99_RS05440	COG0419	ATPase involved in DNA repair
H3L99_RS05445	COG0420	3'-5' exonuclease activity
H3L99_RS05450	COG1739	Uncharacterized protein family UPF0029
H3L99_RS05455	COG1832	CoA-binding protein
H3L99_RS05510	COG2124	cytochrome p450
H3L99_RS05545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H3L99_RS05560	COG1968	undecaprenyl-diphosphatase activity
H3L99_RS05570	COG2813	Specifically methylates the guanine in position
H3L99_RS05575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H3L99_RS05585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H3L99_RS05605	COG2318	DinB family
H3L99_RS05615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H3L99_RS05665	COG0640	Transcriptional regulator
H3L99_RS05670	COG0640	Transcriptional regulator
H3L99_RS05675	COG2072	flavoprotein involved in K transport
H3L99_RS05685	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H3L99_RS05715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H3L99_RS05720	COG0443	Heat shock 70 kDa protein
H3L99_RS05725	COG0484	heat shock protein binding
H3L99_RS05800	COG0384	phenazine biosynthesis protein PhzF
H3L99_RS05830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H3L99_RS05830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H3L99_RS05860	COG1716	ATPase activity
H3L99_RS05880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H3L99_RS05910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3L99_RS05935	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H3L99_RS05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3L99_RS05955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3L99_RS05960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3L99_RS05975	COG2018	Roadblock/LC7 domain
H3L99_RS06005	COG2814	Major facilitator Superfamily
H3L99_RS06015	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS06020	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS06065	COG2270	Major facilitator Superfamily
H3L99_RS06075	COG3030	protein affecting phage T7 exclusion by the F plasmid
H3L99_RS06080	COG1216	Glycosyl transferase, family 2
H3L99_RS06100	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS06115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H3L99_RS06120	COG0464	growth
H3L99_RS06140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H3L99_RS06145	COG0140	phosphoribosyl-ATP diphosphatase activity
H3L99_RS06150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H3L99_RS06155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3L99_RS06155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3L99_RS06160	COG3201	nicotinamide mononucleotide transporter
H3L99_RS06185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H3L99_RS06195	COG0738	Major facilitator superfamily
H3L99_RS06215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H3L99_RS06225	COG0531	amino acid
H3L99_RS06235	COG1191	sigma factor activity
H3L99_RS06245	COG2390	Transcriptional regulator
H3L99_RS06250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H3L99_RS06255	COG2409	Drug exporters of the RND superfamily
H3L99_RS06265	COG0604	alcohol dehydrogenase
H3L99_RS06275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H3L99_RS06290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H3L99_RS06315	COG0284	orotidine-5'-phosphate decarboxylase activity
H3L99_RS06320	COG0167	dihydroorotate dehydrogenase activity
H3L99_RS06325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3L99_RS06330	COG0505	Belongs to the CarA family
H3L99_RS06340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3L99_RS06345	COG0540	Belongs to the ATCase OTCase family
H3L99_RS06350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H3L99_RS06360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H3L99_RS06365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H3L99_RS06370	COG0006	proline dipeptidase activity
H3L99_RS06380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H3L99_RS06385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H3L99_RS06390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H3L99_RS06395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H3L99_RS06405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H3L99_RS06415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H3L99_RS06420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H3L99_RS06440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H3L99_RS06460	COG0124	histidyl-tRNA synthetase
H3L99_RS06475	COG1196	nuclear chromosome segregation
H3L99_RS06490	COG0515	serine threonine protein kinase
H3L99_RS06490	COG2815	serine threonine protein kinase
H3L99_RS06495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3L99_RS06500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H3L99_RS06505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3L99_RS06510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3L99_RS06520	COG2255	four-way junction helicase activity
H3L99_RS06525	COG0632	four-way junction helicase activity
H3L99_RS06530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H3L99_RS06535	COG0217	transcriptional regulatory protein
H3L99_RS06540	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H3L99_RS06545	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H3L99_RS06555	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS06560	COG1560	Kdo2-lipid A biosynthetic process
H3L99_RS06565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H3L99_RS06585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H3L99_RS06600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H3L99_RS06655	COG0456	acetyltransferase
H3L99_RS06665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H3L99_RS06730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H3L99_RS06745	COG1464	Belongs to the NlpA lipoprotein family
H3L99_RS06750	COG2011	ABC-type metal ion transport system permease component
H3L99_RS06780	COG0584	glycerophosphoryl diester phosphodiesterase
H3L99_RS06785	COG0204	Acyl-transferase
H3L99_RS06785	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS06790	COG0477	Major facilitator Superfamily
H3L99_RS06800	COG3629	intracellular signal transduction
H3L99_RS06800	COG3903	Transcriptional regulator
H3L99_RS06815	COG3973	AAA domain
H3L99_RS06820	COG0165	Argininosuccinate lyase
H3L99_RS06825	COG0137	argininosuccinate synthase activity
H3L99_RS06840	COG1438	arginine binding
H3L99_RS06845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3L99_RS06850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H3L99_RS06860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H3L99_RS06880	COG0697	spore germination
H3L99_RS06890	COG0477	Major facilitator Superfamily
H3L99_RS06900	COG4106	trans-aconitate 2-methyltransferase activity
H3L99_RS06910	COG0697	spore germination
H3L99_RS06950	COG0697	spore germination
H3L99_RS06960	COG1649	PFAM Uncharacterised BCR, COG1649
H3L99_RS06985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H3L99_RS06990	COG5002	protein histidine kinase activity
H3L99_RS06995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3L99_RS07000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H3L99_RS07005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H3L99_RS07010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H3L99_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS07050	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS07055	COG0174	glutamine synthetase
H3L99_RS07065	COG0531	amino acid
H3L99_RS07070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H3L99_RS07100	COG4175	Glycine betaine
H3L99_RS07100	COG0517	IMP dehydrogenase activity
H3L99_RS07105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3L99_RS07145	COG0805	protein transport
H3L99_RS07150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H3L99_RS07170	COG2378	regulation of single-species biofilm formation
H3L99_RS07180	COG0545	Peptidyl-prolyl cis-trans isomerase
H3L99_RS07185	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H3L99_RS07195	COG1609	Transcriptional regulator
H3L99_RS07200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H3L99_RS07205	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H3L99_RS07215	COG4122	O-methyltransferase activity
H3L99_RS07220	COG1222	aaa ATPase
H3L99_RS07240	COG1994	Peptidase M50
H3L99_RS07240	COG0517	IMP dehydrogenase activity
H3L99_RS07250	COG2197	response regulator
H3L99_RS07255	COG0747	negative chemotaxis
H3L99_RS07265	COG1410	methionine synthase
H3L99_RS07265	COG0646	methionine synthase
H3L99_RS07270	COG1414	Transcriptional regulator
H3L99_RS07275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3L99_RS07280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3L99_RS07285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H3L99_RS07290	COG2186	Transcriptional regulator
H3L99_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS07300	COG4948	Mandelate Racemase Muconate Lactonizing
H3L99_RS07315	COG0215	cysteine-tRNA ligase activity
H3L99_RS07335	COG0598	Magnesium transport protein CorA
H3L99_RS07350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3L99_RS07355	COG0667	Aldo Keto reductase
H3L99_RS07395	COG0156	8-amino-7-oxononanoate synthase activity
H3L99_RS07415	COG0564	pseudouridine synthase activity
H3L99_RS07430	COG1113	amino acid transport
H3L99_RS07435	COG2186	Transcriptional regulator
H3L99_RS07440	COG3265	gluconokinase activity
H3L99_RS07465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H3L99_RS07470	COG2149	membrane
H3L99_RS07495	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS07505	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS07510	COG0300	oxidoreductase activity
H3L99_RS07515	COG3876	Protein conserved in bacteria
H3L99_RS07560	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS07570	COG0640	Transcriptional regulator
H3L99_RS07580	COG0477	Major facilitator Superfamily
H3L99_RS07595	COG3842	ATPase activity
H3L99_RS07615	COG2851	Citrate transporter
H3L99_RS07620	COG0243	molybdopterin cofactor binding
H3L99_RS07625	COG1309	transcriptional regulator
H3L99_RS07630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H3L99_RS07635	COG2188	Transcriptional regulator
H3L99_RS07665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3L99_RS07675	COG0515	serine threonine protein kinase
H3L99_RS07680	COG2755	lipolytic protein G-D-S-L family
H3L99_RS07695	COG1725	Transcriptional regulator
H3L99_RS07725	COG4565	transcriptional regulatory protein
H3L99_RS07735	COG0789	Transcriptional regulator
H3L99_RS07770	COG0587	DNA-directed DNA polymerase activity
H3L99_RS07775	COG0477	Major facilitator Superfamily
H3L99_RS07780	COG1309	transcriptional regulator
H3L99_RS07800	COG3629	intracellular signal transduction
H3L99_RS07800	COG3903	Transcriptional regulator
H3L99_RS07815	COG0641	radical SAM
H3L99_RS07850	COG1799	cell septum assembly
H3L99_RS07855	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS07860	COG0477	Major facilitator Superfamily
H3L99_RS07885	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS07925	COG1160	GTP binding
H3L99_RS07935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H3L99_RS07980	COG1187	pseudouridine synthase activity
H3L99_RS07985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H3L99_RS07990	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H3L99_RS08005	COG0686	Belongs to the AlaDH PNT family
H3L99_RS08015	COG0494	nUDIX hydrolase
H3L99_RS08020	COG0504	CTP synthase activity
H3L99_RS08025	COG3387	PFAM Glycoside hydrolase 15-related
H3L99_RS08040	COG0497	DNA recombination
H3L99_RS08045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H3L99_RS08065	COG1120	ATPase activity
H3L99_RS08070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS08075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS08080	COG0647	UMP catabolic process
H3L99_RS08115	COG2094	Belongs to the DNA glycosylase MPG family
H3L99_RS08125	COG1881	PFAM PEBP family protein
H3L99_RS08150	COG1119	ATPase activity
H3L99_RS08165	COG2197	response regulator
H3L99_RS08170	COG4585	Histidine kinase
H3L99_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS08180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H3L99_RS08190	COG1131	(ABC) transporter
H3L99_RS08190	COG1716	ATPase activity
H3L99_RS08190	COG0842	Transport permease protein
H3L99_RS08195	COG3830	Belongs to the UPF0237 family
H3L99_RS08195	COG0560	Phosphoserine phosphatase
H3L99_RS08210	COG2807	transmembrane transport
H3L99_RS08215	COG2186	Transcriptional regulator
H3L99_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS08245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H3L99_RS08265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H3L99_RS08270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L99_RS08285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3L99_RS08300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3L99_RS08315	COG3387	PFAM Glycoside hydrolase 15-related
H3L99_RS08365	COG0488	(ABC) transporter
H3L99_RS08385	COG0235	Class ii aldolase
H3L99_RS08400	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H3L99_RS08405	COG1492	cobalamin metabolic process
H3L99_RS08420	COG1797	cobyrinic acid a,c-diamide synthase activity
H3L99_RS08445	COG1595	DNA-templated transcription, initiation
H3L99_RS08455	COG0736	holo-[acyl-carrier-protein] synthase activity
H3L99_RS08460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H3L99_RS08475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3L99_RS08515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H3L99_RS08530	COG1917	Cupin 2, conserved barrel domain protein
H3L99_RS08540	COG1902	pentaerythritol trinitrate reductase activity
H3L99_RS08580	COG1414	Transcriptional regulator
H3L99_RS08595	COG4585	Histidine kinase
H3L99_RS08600	COG2197	response regulator
H3L99_RS08605	COG0768	penicillin binding
H3L99_RS08625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3L99_RS08630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H3L99_RS08670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3L99_RS08680	COG2171	N-acyltransferase activity
H3L99_RS08700	COG0822	iron-sulfur transferase activity
H3L99_RS08705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H3L99_RS08710	COG0396	ATPase activity
H3L99_RS08720	COG0719	Fe-S assembly protein
H3L99_RS08765	COG0109	protoheme IX farnesyltransferase activity
H3L99_RS08775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H3L99_RS08790	COG0363	glucosamine-6-phosphate deaminase activity
H3L99_RS08800	COG1131	(ABC) transporter
H3L99_RS08805	COG4585	Histidine kinase
H3L99_RS08810	COG2197	response regulator
H3L99_RS08815	COG1846	Transcriptional regulator
H3L99_RS08835	COG0166	Belongs to the GPI family
H3L99_RS08845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H3L99_RS08855	COG0126	phosphoglycerate kinase activity
H3L99_RS08860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H3L99_RS08870	COG1481	regulation of sporulation
H3L99_RS08875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H3L99_RS08880	COG1660	Displays ATPase and GTPase activities
H3L99_RS08885	COG0322	excinuclease ABC activity
H3L99_RS08900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3L99_RS08935	COG0556	nucleotide-excision repair
H3L99_RS08945	COG0584	glycerophosphoryl diester phosphodiesterase
H3L99_RS08950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3L99_RS08955	COG0477	Major facilitator Superfamily
H3L99_RS08975	COG2313	pseudouridylate synthase activity
H3L99_RS09000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3L99_RS09015	COG0402	S-adenosylhomocysteine deaminase activity
H3L99_RS09030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H3L99_RS09055	COG0237	dephospho-CoA kinase activity
H3L99_RS09070	COG0539	negative regulation of cytoplasmic translation
H3L99_RS09075	COG2226	methyltransferase
H3L99_RS09080	COG1643	Atp-dependent helicase
H3L99_RS09115	COG2050	protein possibly involved in aromatic compounds catabolism
H3L99_RS09120	COG1132	(ABC) transporter
H3L99_RS09145	COG0681	Belongs to the peptidase S26 family
H3L99_RS09150	COG3903	Transcriptional regulator
H3L99_RS09150	COG3629	intracellular signal transduction
H3L99_RS09175	COG0683	leucine binding
H3L99_RS09205	COG0737	Belongs to the 5'-nucleotidase family
H3L99_RS09225	COG0287	Prephenate dehydrogenase
H3L99_RS09225	COG1605	Chorismate mutase
H3L99_RS09255	COG2732	(Barnase) inhibitor
H3L99_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS09275	COG1024	Enoyl-CoA hydratase
H3L99_RS09295	COG3795	YCII-related domain
H3L99_RS09300	COG4941	Belongs to the sigma-70 factor family
H3L99_RS09310	COG1278	Cold shock
H3L99_RS09315	COG0183	Belongs to the thiolase family
H3L99_RS09320	COG1309	transcriptional regulator
H3L99_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS09330	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS09335	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS09365	COG1397	ADP-ribosylglycohydrolase
H3L99_RS09385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3L99_RS09390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3L99_RS09400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H3L99_RS09410	COG0159	tryptophan synthase activity
H3L99_RS09415	COG0133	tryptophan synthase activity
H3L99_RS09425	COG0134	indole-3-glycerol-phosphate synthase activity
H3L99_RS09450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H3L99_RS09460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L99_RS09465	COG2508	Transcriptional regulator
H3L99_RS09480	COG0107	imidazoleglycerol-phosphate synthase activity
H3L99_RS09485	COG0251	oxidation-reduction process
H3L99_RS09490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H3L99_RS09495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H3L99_RS09505	COG0131	Imidazoleglycerol-phosphate dehydratase
H3L99_RS09510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H3L99_RS09515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H3L99_RS09555	COG1432	Conserved Protein
H3L99_RS09565	COG0587	DNA-directed DNA polymerase activity
H3L99_RS09620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H3L99_RS09630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H3L99_RS09635	COG3599	regulation of cell shape
H3L99_RS09645	COG1799	cell septum assembly
H3L99_RS09650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H3L99_RS09665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H3L99_RS09670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H3L99_RS09685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H3L99_RS09695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H3L99_RS09710	COG0275	rRNA processing
H3L99_RS09720	COG0714	Associated with various cellular activities
H3L99_RS09750	COG1121	(ABC) transporter
H3L99_RS09760	COG1309	transcriptional regulator
H3L99_RS09785	COG0352	thiamine-phosphate diphosphorylase activity
H3L99_RS09805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3L99_RS09805	COG2022	thiamine diphosphate biosynthetic process
H3L99_RS09815	COG2022	thiamine diphosphate biosynthetic process
H3L99_RS09820	COG2815	serine threonine protein kinase
H3L99_RS09820	COG0515	serine threonine protein kinase
H3L99_RS09825	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H3L99_RS09835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H3L99_RS09840	COG2193	ferroxidase activity
H3L99_RS09850	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H3L99_RS09870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3L99_RS09875	COG0205	6-phosphofructokinase activity
H3L99_RS09880	COG2197	response regulator
H3L99_RS09885	COG4585	Histidine kinase
H3L99_RS09910	COG1940	carbohydrate kinase activity
H3L99_RS09920	COG0003	Pfam Anion-transporting ATPase
H3L99_RS09940	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS09990	COG2205	protein histidine kinase activity
H3L99_RS09995	COG0745	RESPONSE REGULATOR receiver
H3L99_RS10005	COG1929	Belongs to the glycerate kinase type-1 family
H3L99_RS10010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H3L99_RS10015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H3L99_RS10020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H3L99_RS10025	COG0723	plastoquinol--plastocyanin reductase activity
H3L99_RS10030	COG2010	Cytochrome c
H3L99_RS10035	COG1845	cytochrome c oxidase, subunit III
H3L99_RS10045	COG1376	ErfK ybiS ycfS ynhG family protein
H3L99_RS10055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H3L99_RS10060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H3L99_RS10070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3L99_RS10090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H3L99_RS10095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H3L99_RS10100	COG2197	response regulator
H3L99_RS10125	COG4106	trans-aconitate 2-methyltransferase activity
H3L99_RS10130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3L99_RS10145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H3L99_RS10155	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H3L99_RS10170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H3L99_RS10175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3L99_RS10180	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3L99_RS10190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H3L99_RS10205	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS10235	COG0321	lipoyl(octanoyl) transferase activity
H3L99_RS10240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H3L99_RS10275	COG1136	(ABC) transporter
H3L99_RS10280	COG0577	efflux transmembrane transporter activity
H3L99_RS10325	COG0745	RESPONSE REGULATOR receiver
H3L99_RS10350	COG2197	response regulator
H3L99_RS10370	COG2365	Tyrosine phosphatase family
H3L99_RS10390	COG1609	Transcriptional regulator
H3L99_RS10400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H3L99_RS10410	COG2226	methyltransferase
H3L99_RS10430	COG0174	glutamine synthetase
H3L99_RS10445	COG2409	Drug exporters of the RND superfamily
H3L99_RS10470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H3L99_RS10470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H3L99_RS10485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H3L99_RS10525	COG1994	Peptidase M50
H3L99_RS10595	COG2814	Major facilitator Superfamily
H3L99_RS10605	COG3540	Alkaline phosphatase
H3L99_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS10685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H3L99_RS10690	COG2815	serine threonine protein kinase
H3L99_RS10690	COG0515	serine threonine protein kinase
H3L99_RS10715	COG0557	exoribonuclease II activity
H3L99_RS10720	COG3022	response to hydroperoxide
H3L99_RS10725	COG0800	Aldolase
H3L99_RS10750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H3L99_RS10755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3L99_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS10775	COG2030	dehydratase
H3L99_RS10780	COG4585	Histidine kinase
H3L99_RS10785	COG2197	response regulator
H3L99_RS10800	COG0789	Transcriptional regulator
H3L99_RS10845	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H3L99_RS10850	COG0860	N-Acetylmuramoyl-L-alanine amidase
H3L99_RS10860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3L99_RS10880	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS10915	COG1657	PFAM Prenyltransferase squalene oxidase
H3L99_RS10930	COG3845	ABC transporter
H3L99_RS10940	COG0183	Belongs to the thiolase family
H3L99_RS10945	COG2124	cytochrome p450
H3L99_RS10950	COG2367	Beta-lactamase
H3L99_RS10980	COG4122	O-methyltransferase activity
H3L99_RS11015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3L99_RS11070	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H3L99_RS11130	COG0500	methyltransferase
H3L99_RS11225	COG4585	Histidine kinase
H3L99_RS11230	COG0586	Pfam SNARE associated Golgi protein
H3L99_RS11240	COG1358	cellular component organization or biogenesis
H3L99_RS11285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H3L99_RS11290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3L99_RS11300	COG0477	Major facilitator Superfamily
H3L99_RS11305	COG1309	transcriptional regulator
H3L99_RS11320	COG4585	Histidine kinase
H3L99_RS11325	COG2197	response regulator
H3L99_RS11340	COG0667	Aldo Keto reductase
H3L99_RS11345	COG0789	Transcriptional regulator
H3L99_RS11365	COG2205	protein histidine kinase activity
H3L99_RS11370	COG0745	RESPONSE REGULATOR receiver
H3L99_RS11415	COG2249	NAD(P)H dehydrogenase (quinone) activity
H3L99_RS11425	COG1741	Belongs to the pirin family
H3L99_RS11440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3L99_RS11445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3L99_RS11450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L99_RS11485	COG1764	response to oxidative stress
H3L99_RS11490	COG2130	NADP-dependent
H3L99_RS11510	COG1077	Cell shape determining protein MreB Mrl
H3L99_RS11520	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS11525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3L99_RS11525	COG0825	malonyl-CoA metabolic process
H3L99_RS11530	COG1404	Belongs to the peptidase S8 family
H3L99_RS11575	COG1070	Carbohydrate kinase
H3L99_RS11605	COG0358	DNA primase activity
H3L99_RS11615	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H3L99_RS11630	COG2949	membrane
H3L99_RS11640	COG0243	molybdopterin cofactor binding
H3L99_RS11695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H3L99_RS11700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H3L99_RS11700	COG2146	nitrite reductase [NAD(P)H] activity
H3L99_RS11725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3L99_RS11725	COG0574	Belongs to the PEP-utilizing enzyme family
H3L99_RS11750	COG0423	glycine-tRNA ligase activity
H3L99_RS11755	COG0803	Belongs to the bacterial solute-binding protein 9 family
H3L99_RS11755	COG3443	Belongs to the bacterial solute-binding protein 9 family
H3L99_RS11760	COG1121	(ABC) transporter
H3L99_RS11765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3L99_RS11815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3L99_RS11820	COG1381	Involved in DNA repair and RecF pathway recombination
H3L99_RS11840	COG2197	response regulator
H3L99_RS11845	COG4585	Histidine kinase
H3L99_RS11850	COG2409	Drug exporters of the RND superfamily
H3L99_RS11860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H3L99_RS11875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H3L99_RS11895	COG2315	Protein conserved in bacteria
H3L99_RS11905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H3L99_RS11915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3L99_RS11930	COG1234	tRNA 3'-trailer cleavage
H3L99_RS11935	COG0537	adenosine 5'-monophosphoramidase activity
H3L99_RS11940	COG4946	Tricorn protease homolog
H3L99_RS11940	COG0793	Belongs to the peptidase S41A family
H3L99_RS11965	COG0484	heat shock protein binding
H3L99_RS11970	COG1420	regulation of RNA biosynthetic process
H3L99_RS12000	COG0481	GTPase activity
H3L99_RS12005	COG0268	Binds directly to 16S ribosomal RNA
H3L99_RS12020	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H3L99_RS12035	COG1555	photosystem II stabilization
H3L99_RS12035	COG1596	polysaccharide export
H3L99_RS12040	COG1307	EDD domain protein, DegV family
H3L99_RS12060	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H3L99_RS12080	COG0588	phosphoglycerate mutase activity
H3L99_RS12085	COG0799	negative regulation of ribosome biogenesis
H3L99_RS12095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H3L99_RS12105	COG0501	Belongs to the peptidase M48B family
H3L99_RS12120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H3L99_RS12130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H3L99_RS12140	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H3L99_RS12165	COG1216	Glycosyl transferase, family 2
H3L99_RS12180	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS12190	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS12195	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS12200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H3L99_RS12205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H3L99_RS12210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H3L99_RS12215	COG1530	ribonuclease E activity
H3L99_RS12255	COG0772	Belongs to the SEDS family
H3L99_RS12260	COG0768	penicillin binding
H3L99_RS12275	COG1077	Cell shape determining protein MreB Mrl
H3L99_RS12280	COG0105	UTP biosynthetic process
H3L99_RS12290	COG0285	dihydrofolate synthase activity
H3L99_RS12295	COG0525	valine-tRNA ligase activity
H3L99_RS12310	COG0740	serine-type endopeptidase activity
H3L99_RS12315	COG0740	serine-type endopeptidase activity
H3L99_RS12320	COG0544	peptidyl-prolyl cis-trans isomerase activity
H3L99_RS12365	COG3594	Acyltransferase
H3L99_RS12370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3L99_RS12375	COG0475	glutathione-regulated potassium exporter activity
H3L99_RS12385	COG4552	Acetyltransferase involved in intracellular survival and related
H3L99_RS12400	COG1113	amino acid transport
H3L99_RS12410	COG1113	amino acid transport
H3L99_RS12415	COG1113	amino acid transport
H3L99_RS12420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H3L99_RS12435	COG0494	nUDIX hydrolase
H3L99_RS12460	COG5002	protein histidine kinase activity
H3L99_RS12480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3L99_RS12510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H3L99_RS12520	COG0668	transmembrane transport
H3L99_RS12535	COG1175	transmembrane transport
H3L99_RS12545	COG1486	melibiose metabolic process
H3L99_RS12560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L99_RS12610	COG1136	(ABC) transporter
H3L99_RS12610	COG0577	efflux transmembrane transporter activity
H3L99_RS12635	COG0629	single-stranded DNA binding
H3L99_RS12700	COG1131	(ABC) transporter
H3L99_RS12725	COG3962	Belongs to the TPP enzyme family
H3L99_RS12730	COG3718	enzyme involved in inositol metabolism
H3L99_RS12770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3L99_RS12820	COG0673	inositol 2-dehydrogenase activity
H3L99_RS12825	COG1609	Transcriptional regulator
H3L99_RS12840	COG1846	Transcriptional regulator
H3L99_RS12840	COG0456	acetyltransferase
H3L99_RS12870	COG1472	Belongs to the glycosyl hydrolase 3 family
H3L99_RS12915	COG1131	(ABC) transporter
H3L99_RS12920	COG4585	Histidine kinase
H3L99_RS12925	COG2197	response regulator
H3L99_RS12930	COG0028	Belongs to the TPP enzyme family
H3L99_RS12940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L99_RS12965	COG1946	Acyl-CoA thioesterase
H3L99_RS12970	COG3851	Histidine kinase
H3L99_RS12975	COG2197	response regulator
H3L99_RS12990	COG1309	transcriptional regulator
H3L99_RS12995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3L99_RS13010	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS13020	COG2375	cellular response to nickel ion
H3L99_RS13030	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H3L99_RS13055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3L99_RS13065	COG0589	response to stress
H3L99_RS13075	COG4977	sequence-specific DNA binding
H3L99_RS13080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H3L99_RS13095	COG1595	DNA-templated transcription, initiation
H3L99_RS13100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3L99_RS13115	COG0789	Transcriptional regulator
H3L99_RS13130	COG1175	transmembrane transport
H3L99_RS13135	COG0395	ABC-type sugar transport system, permease component
H3L99_RS13230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3L99_RS13240	COG1349	DNA-binding transcription factor activity
H3L99_RS13255	COG1175	transmembrane transport
H3L99_RS13265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3L99_RS13285	COG0154	amidase activity
H3L99_RS13295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L99_RS13300	COG0765	amino acid transport
H3L99_RS13305	COG0765	amino acid transport
H3L99_RS13310	COG1126	abc transporter atp-binding protein
H3L99_RS13390	COG0673	inositol 2-dehydrogenase activity
H3L99_RS13395	COG4702	Belongs to the UPF0303 family
H3L99_RS13405	COG1742	UPF0060 membrane protein
H3L99_RS13420	COG4213	ABC transporter substrate-binding protein
H3L99_RS13425	COG3764	Sortase (surface protein transpeptidase)
H3L99_RS13490	COG1074	ATP-dependent DNA helicase activity
H3L99_RS13550	COG2733	membrane
H3L99_RS13565	COG4555	ABC transporter
H3L99_RS13580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3L99_RS13590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H3L99_RS13605	COG0477	Major facilitator Superfamily
H3L99_RS13625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H3L99_RS13635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H3L99_RS13640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3L99_RS13645	COG1263	PTS System
H3L99_RS13650	COG1263	PTS System
H3L99_RS13655	COG1234	tRNA 3'-trailer cleavage
H3L99_RS13675	COG1113	amino acid transport
H3L99_RS13685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H3L99_RS13695	COG1335	isochorismatase
H3L99_RS13730	COG0277	FAD linked oxidase domain protein
H3L99_RS13740	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H3L99_RS13825	COG0515	serine threonine protein kinase
H3L99_RS13825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3L99_RS13835	COG1404	Belongs to the peptidase S8 family
H3L99_RS13865	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H3L99_RS13870	COG0395	ABC-type sugar transport system, permease component
H3L99_RS13875	COG1175	transmembrane transport
H3L99_RS13890	COG1678	Uncharacterized ACR, COG1678
H3L99_RS13895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H3L99_RS13900	COG0776	regulation of translation
H3L99_RS13910	COG3973	AAA domain
H3L99_RS13960	COG0583	DNA-binding transcription factor activity
H3L99_RS13975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H3L99_RS13980	COG3409	Peptidoglycan-binding domain 1 protein
H3L99_RS13980	COG0793	Belongs to the peptidase S41A family
H3L99_RS13990	COG2884	Cell division ATP-binding protein ftsE
H3L99_RS14005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H3L99_RS14010	COG0515	serine threonine protein kinase
H3L99_RS14015	COG0515	serine threonine protein kinase
H3L99_RS14020	COG1674	ftsk spoiiie
H3L99_RS14035	COG0395	ABC-type sugar transport system, permease component
H3L99_RS14055	COG1309	transcriptional regulator
H3L99_RS14065	COG1388	LysM domain
H3L99_RS14065	COG1134	teichoic acid transport
H3L99_RS14075	COG2902	Dehydrogenase
H3L99_RS14100	COG0653	protein targeting
H3L99_RS14110	COG3214	Protein conserved in bacteria
H3L99_RS14120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H3L99_RS14130	COG0823	Involved in the tonB-independent uptake of proteins
H3L99_RS14135	COG5000	phosphorelay sensor kinase activity
H3L99_RS14135	COG5002	protein histidine kinase activity
H3L99_RS14140	COG0745	RESPONSE REGULATOR receiver
H3L99_RS14145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H3L99_RS14165	COG0714	Associated with various cellular activities
H3L99_RS14205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H3L99_RS14215	COG1482	cell wall glycoprotein biosynthetic process
H3L99_RS14225	COG2835	tetraacyldisaccharide 4'-kinase activity
H3L99_RS14230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3L99_RS14270	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H3L99_RS14275	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H3L99_RS14275	COG0778	Nitroreductase
H3L99_RS14305	COG1316	TRANSCRIPTIONal
H3L99_RS14320	COG1316	TRANSCRIPTIONal
H3L99_RS14325	COG1607	acyl-coa hydrolase
H3L99_RS14330	COG1316	TRANSCRIPTIONal
H3L99_RS14345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H3L99_RS14370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H3L99_RS14390	COG0745	RESPONSE REGULATOR receiver
H3L99_RS14395	COG3104	oligopeptide transport
H3L99_RS14435	COG1191	sigma factor activity
H3L99_RS14455	COG1794	racemase activity, acting on amino acids and derivatives
H3L99_RS14465	COG1228	amidohydrolase
H3L99_RS14480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H3L99_RS14485	COG0019	diaminopimelate decarboxylase activity
H3L99_RS14540	COG2755	lipolytic protein G-D-S-L family
H3L99_RS14545	COG0183	Belongs to the thiolase family
H3L99_RS14575	COG1136	(ABC) transporter
H3L99_RS14580	COG0577	efflux transmembrane transporter activity
H3L99_RS14580	COG1136	(ABC) transporter
H3L99_RS14585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H3L99_RS14590	COG1252	NADH dehydrogenase
H3L99_RS14615	COG0148	phosphopyruvate hydratase activity
H3L99_RS14630	COG2124	cytochrome p450
H3L99_RS14645	COG1215	transferase activity, transferring glycosyl groups
H3L99_RS14655	COG0596	Alpha beta hydrolase
H3L99_RS14665	COG0463	Glycosyl transferase, family 2
H3L99_RS14720	COG0577	efflux transmembrane transporter activity
H3L99_RS14720	COG1136	(ABC) transporter
H3L99_RS14725	COG1136	(ABC) transporter
H3L99_RS14730	COG0477	Major facilitator Superfamily
H3L99_RS14745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L99_RS14770	COG4585	Histidine kinase
H3L99_RS14785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H3L99_RS14790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H3L99_RS14795	COG0193	aminoacyl-tRNA hydrolase activity
H3L99_RS14815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H3L99_RS14835	COG4106	trans-aconitate 2-methyltransferase activity
H3L99_RS14840	COG1846	Transcriptional regulator
H3L99_RS14845	COG2197	response regulator
H3L99_RS14880	COG0488	(ABC) transporter
H3L99_RS14890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H3L99_RS14895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H3L99_RS14905	COG0084	hydrolase, TatD family'
H3L99_RS14935	COG0442	prolyl-tRNA aminoacylation
H3L99_RS14955	COG1764	response to oxidative stress
H3L99_RS14965	COG1122	ATPase activity
H3L99_RS14975	COG0310	cobalt ion transport
H3L99_RS14985	COG2409	Drug exporters of the RND superfamily
H3L99_RS15010	COG2267	carboxylic ester hydrolase activity
H3L99_RS15015	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS15065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H3L99_RS15070	COG0521	Mo-molybdopterin cofactor biosynthetic process
H3L99_RS15075	COG0315	cyclic pyranopterin monophosphate synthase activity
H3L99_RS15085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H3L99_RS15090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H3L99_RS15115	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H3L99_RS15125	COG1970	mechanosensitive ion channel activity
H3L99_RS15145	COG0477	Major facilitator Superfamily
H3L99_RS15160	COG1247	-acetyltransferase
H3L99_RS15165	COG3384	dioxygenase
H3L99_RS15170	COG1846	Transcriptional regulator
H3L99_RS15215	COG1309	transcriptional regulator
H3L99_RS15240	COG0456	acetyltransferase
H3L99_RS15265	COG1686	Belongs to the peptidase S11 family
H3L99_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS15305	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H3L99_RS15360	COG3209	COG3209 Rhs family protein
H3L99_RS15430	COG0531	amino acid
H3L99_RS15520	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS15535	COG1024	Enoyl-CoA hydratase
H3L99_RS15545	COG1309	transcriptional regulator
H3L99_RS15570	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS15580	COG0259	pyridoxamine-phosphate oxidase activity
H3L99_RS15595	COG2072	flavoprotein involved in K transport
H3L99_RS15605	COG1024	Enoyl-CoA hydratase
H3L99_RS15610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H3L99_RS15635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H3L99_RS15640	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS15660	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS15665	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS15675	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS15730	COG1653	transport
H3L99_RS15785	COG0596	Alpha beta hydrolase
H3L99_RS15785	COG2945	thiolester hydrolase activity
H3L99_RS15795	COG4821	SIS domain
H3L99_RS15810	COG0259	pyridoxamine-phosphate oxidase activity
H3L99_RS15845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3L99_RS15870	COG5006	permease, DMT superfamily
H3L99_RS15875	COG0583	DNA-binding transcription factor activity
H3L99_RS15880	COG0259	pyridoxamine-phosphate oxidase activity
H3L99_RS15895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H3L99_RS15985	COG0667	Aldo Keto reductase
H3L99_RS16015	COG2252	PERMEase
H3L99_RS16025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H3L99_RS16045	COG0596	Alpha beta hydrolase
H3L99_RS16055	COG1366	Belongs to the anti-sigma-factor antagonist family
H3L99_RS16085	COG2197	response regulator
H3L99_RS16095	COG0577	efflux transmembrane transporter activity
H3L99_RS16095	COG1136	(ABC) transporter
H3L99_RS16135	COG2814	Major facilitator Superfamily
H3L99_RS16145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H3L99_RS16150	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H3L99_RS16155	COG1278	Cold shock
H3L99_RS16170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS16175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS16180	COG1120	ATPase activity
H3L99_RS16185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H3L99_RS16205	COG1061	Type III restriction enzyme res subunit
H3L99_RS16225	COG1122	ATPase activity
H3L99_RS16230	COG3973	AAA domain
H3L99_RS16265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H3L99_RS16270	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H3L99_RS16290	COG0577	efflux transmembrane transporter activity
H3L99_RS16290	COG1136	(ABC) transporter
H3L99_RS16355	COG0463	Glycosyl transferase, family 2
H3L99_RS16370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3L99_RS16370	COG1877	trehalose-phosphatase activity
H3L99_RS16390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H3L99_RS16395	COG1105	Belongs to the carbohydrate kinase PfkB family
H3L99_RS16415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H3L99_RS16435	COG4191	Histidine kinase
H3L99_RS16440	COG2197	response regulator
H3L99_RS16475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3L99_RS16490	COG3842	ATPase activity
H3L99_RS16500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H3L99_RS16515	COG0215	cysteine-tRNA ligase activity
H3L99_RS16520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H3L99_RS16525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H3L99_RS16530	COG1329	Transcriptional regulator
H3L99_RS16545	COG5002	protein histidine kinase activity
H3L99_RS16595	COG4974	Belongs to the 'phage' integrase family
H3L99_RS16605	COG0588	phosphoglycerate mutase activity
H3L99_RS16635	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS16680	COG0667	Aldo Keto reductase
H3L99_RS16715	COG2188	Transcriptional regulator
H3L99_RS16735	COG4552	Acetyltransferase involved in intracellular survival and related
H3L99_RS16750	COG1490	D-aminoacyl-tRNA deacylase activity
H3L99_RS16755	COG0354	folic acid binding
H3L99_RS16765	COG3485	protocatechuate 3,4-dioxygenase
H3L99_RS16800	COG2897	thiosulfate sulfurtransferase activity
H3L99_RS16825	COG0745	RESPONSE REGULATOR receiver
H3L99_RS16830	COG1609	Transcriptional regulator
H3L99_RS16835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3L99_RS16850	COG0488	(ABC) transporter
H3L99_RS16860	COG0737	Belongs to the 5'-nucleotidase family
H3L99_RS16865	COG0456	acetyltransferase
H3L99_RS16870	COG1725	Transcriptional regulator
H3L99_RS16875	COG1131	(ABC) transporter
H3L99_RS16885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H3L99_RS16900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H3L99_RS16915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H3L99_RS16920	COG0306	phosphate transporter
H3L99_RS16930	COG1937	Protein conserved in bacteria
H3L99_RS16950	COG0277	FAD linked oxidase domain protein
H3L99_RS16955	COG0671	phosphoesterase, PA-phosphatase related
H3L99_RS16960	COG1196	nuclear chromosome segregation
H3L99_RS16960	COG0739	heme binding
H3L99_RS16960	COG0741	lytic transglycosylase activity
H3L99_RS17010	COG1131	(ABC) transporter
H3L99_RS17020	COG4585	Histidine kinase
H3L99_RS17025	COG2197	response regulator
H3L99_RS17045	COG1846	Transcriptional regulator
H3L99_RS17060	COG1252	NADH dehydrogenase
H3L99_RS17085	COG0579	oxidoreductase
H3L99_RS17090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H3L99_RS17100	COG0667	Aldo Keto reductase
H3L99_RS17105	COG1196	nuclear chromosome segregation
H3L99_RS17105	COG0741	lytic transglycosylase activity
H3L99_RS17105	COG0739	heme binding
H3L99_RS17120	COG1017	nitric oxide dioxygenase activity
H3L99_RS17120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H3L99_RS17125	COG1959	2 iron, 2 sulfur cluster binding
H3L99_RS17130	COG2226	methyltransferase
H3L99_RS17160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3L99_RS17165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3L99_RS17195	COG0785	Cytochrome C biogenesis protein
H3L99_RS17200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H3L99_RS17200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H3L99_RS17210	COG1643	Atp-dependent helicase
H3L99_RS17235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H3L99_RS17245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H3L99_RS17275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3L99_RS17280	COG0047	phosphoribosylformylglycinamidine synthase activity
H3L99_RS17285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3L99_RS17310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H3L99_RS17325	COG0151	Belongs to the GarS family
H3L99_RS17365	COG4941	Belongs to the sigma-70 factor family
H3L99_RS17390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H3L99_RS17425	COG1191	sigma factor activity
H3L99_RS17430	COG1191	sigma factor activity
H3L99_RS17455	COG2353	YceI-like domain
H3L99_RS17460	COG3467	pyridoxamine 5'-phosphate
H3L99_RS17470	COG0477	Major facilitator Superfamily
H3L99_RS17475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H3L99_RS17475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H3L99_RS17485	COG2205	protein histidine kinase activity
H3L99_RS17490	COG0745	RESPONSE REGULATOR receiver
H3L99_RS17500	COG1404	Belongs to the peptidase S8 family
H3L99_RS17540	COG0784	Response regulator, receiver
H3L99_RS17545	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS17550	COG1595	DNA-templated transcription, initiation
H3L99_RS17580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H3L99_RS17595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3L99_RS17630	COG0006	proline dipeptidase activity
H3L99_RS17650	COG1999	signal sequence binding
H3L99_RS17660	COG2372	response to copper ion
H3L99_RS17665	COG2837	iron assimilation
H3L99_RS17675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H3L99_RS17680	COG0561	phosphatase activity
H3L99_RS17705	COG1131	(ABC) transporter
H3L99_RS17715	COG0789	Transcriptional regulator
H3L99_RS17720	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H3L99_RS17730	COG0561	phosphatase activity
H3L99_RS17735	COG1196	nuclear chromosome segregation
H3L99_RS17735	COG0739	heme binding
H3L99_RS17735	COG0741	lytic transglycosylase activity
H3L99_RS17745	COG4988	ABC transporter
H3L99_RS17750	COG1294	oxidase, subunit
H3L99_RS17755	COG1271	oxidase subunit
H3L99_RS17760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H3L99_RS17765	COG1609	Transcriptional regulator
H3L99_RS17780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H3L99_RS17805	COG0662	Cupin 2, conserved barrel domain protein
H3L99_RS17810	COG1950	PFAM Membrane protein of
H3L99_RS17815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H3L99_RS17820	COG0626	cystathionine gamma-synthase activity
H3L99_RS17860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3L99_RS17895	COG2814	Major facilitator Superfamily
H3L99_RS17905	COG0305	Participates in initiation and elongation during chromosome replication
H3L99_RS17915	COG0359	binds to the 23S rRNA
H3L99_RS17920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H3L99_RS17925	COG0629	single-stranded DNA binding
H3L99_RS17930	COG0360	Binds together with S18 to 16S ribosomal RNA
H3L99_RS17955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3L99_RS17980	COG0617	tRNA 3'-terminal CCA addition
H3L99_RS17995	COG2815	serine threonine protein kinase
H3L99_RS17995	COG0515	serine threonine protein kinase
H3L99_RS18000	COG1595	DNA-templated transcription, initiation
H3L99_RS18010	COG0492	ferredoxin-NADP+ reductase activity
H3L99_RS18015	COG3118	belongs to the thioredoxin family
H3L99_RS18030	COG1192	Involved in chromosome partitioning
H3L99_RS18035	COG0357	Ribosomal RNA small subunit methyltransferase G
H3L99_RS18045	COG0706	membrane insertase activity
H3L99_RS18050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H3L99_RS18055	COG0594	ribonuclease P activity
H3L99_RS18060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H3L99_RS18065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H3L99_RS18070	COG0592	DNA-directed DNA polymerase activity
H3L99_RS18075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H3L99_RS18080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H3L99_RS18085	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H3L99_RS18095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3L99_RS18125	COG0515	serine threonine protein kinase
H3L99_RS18175	COG4152	abc transporter atp-binding protein
H3L99_RS18185	COG1132	(ABC) transporter
H3L99_RS18190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3L99_RS18195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H3L99_RS18240	COG0705	Rhomboid family
H3L99_RS18240	COG0457	Tetratricopeptide repeat
H3L99_RS18255	COG3764	Sortase (surface protein transpeptidase)
H3L99_RS18270	COG3764	Sortase (surface protein transpeptidase)
H3L99_RS18275	COG3764	Sortase (surface protein transpeptidase)
H3L99_RS18280	COG0515	serine threonine protein kinase
H3L99_RS18285	COG0768	penicillin binding
H3L99_RS18300	COG1716	ATPase activity
H3L99_RS18305	COG1716	ATPase activity
H3L99_RS18325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H3L99_RS18330	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS18335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H3L99_RS18340	COG2151	metal-sulfur cluster biosynthetic enzyme
H3L99_RS18345	COG3396	Phenylacetate-CoA oxygenase
H3L99_RS18350	COG3460	Phenylacetate-CoA oxygenase
H3L99_RS18355	COG3396	Phenylacetate-CoA oxygenase
H3L99_RS18380	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3L99_RS18385	COG1309	transcriptional regulator
H3L99_RS18420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H3L99_RS18425	COG0604	alcohol dehydrogenase
H3L99_RS18440	COG4591	ABC-type transport system involved in lipoprotein release permease component
H3L99_RS18440	COG1136	(ABC) transporter
H3L99_RS18455	COG0515	serine threonine protein kinase
H3L99_RS18460	COG0515	serine threonine protein kinase
H3L99_RS18485	COG0022	dehydrogenase e1 component
H3L99_RS18490	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3L99_RS18500	COG2271	Major facilitator Superfamily
H3L99_RS18535	COG1362	aminopeptidase activity
H3L99_RS18540	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS18550	COG1741	Belongs to the pirin family
H3L99_RS18565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H3L99_RS18590	COG2304	oxidoreductase activity
H3L99_RS18615	COG1289	transmembrane transporter activity
H3L99_RS18665	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3L99_RS18665	COG1902	pentaerythritol trinitrate reductase activity
H3L99_RS18685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H3L99_RS18700	COG3509	depolymerase
H3L99_RS18745	COG1115	amino acid carrier protein
H3L99_RS18765	COG0189	ligase activity
H3L99_RS18780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H3L99_RS18785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3L99_RS18790	COG3959	Transketolase, thiamine diphosphate binding domain
H3L99_RS18795	COG3958	Transketolase
H3L99_RS18800	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H3L99_RS18820	COG2197	response regulator
H3L99_RS18865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H3L99_RS18880	COG0717	Belongs to the dCTP deaminase family
H3L99_RS18900	COG2181	nitrate reductase activity
H3L99_RS18900	COG0247	lactate metabolic process
H3L99_RS18905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3L99_RS18910	COG0443	Heat shock 70 kDa protein
H3L99_RS18915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H3L99_RS18920	COG0484	heat shock protein binding
H3L99_RS18925	COG0789	Transcriptional regulator
H3L99_RS18955	COG0542	response to heat
H3L99_RS18980	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H3L99_RS18995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H3L99_RS19000	COG0191	fructose-bisphosphate aldolase activity
H3L99_RS19005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H3L99_RS19010	COG0477	Major facilitator Superfamily
H3L99_RS19030	COG3844	kynureninase activity
H3L99_RS19050	COG2197	response regulator
H3L99_RS19055	COG2124	cytochrome p450
H3L99_RS19060	COG3559	Exporter of polyketide antibiotics
H3L99_RS19065	COG1131	(ABC) transporter
H3L99_RS19080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H3L99_RS19090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H3L99_RS19120	COG0693	protein deglycase activity
H3L99_RS19135	COG1802	Transcriptional regulator
H3L99_RS19150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H3L99_RS19155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H3L99_RS19175	COG1595	DNA-templated transcription, initiation
H3L99_RS19235	COG1408	metallophosphoesterase
H3L99_RS19250	COG1610	YqeY-like protein
H3L99_RS19255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3L99_RS19265	COG0003	Pfam Anion-transporting ATPase
H3L99_RS19290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H3L99_RS19320	COG2267	carboxylic ester hydrolase activity
H3L99_RS19330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H3L99_RS19335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3L99_RS19340	COG0659	secondary active sulfate transmembrane transporter activity
H3L99_RS19400	COG1111	helicase
H3L99_RS19400	COG1205	dead DEAH box helicase
H3L99_RS19405	COG1366	Belongs to the anti-sigma-factor antagonist family
H3L99_RS19410	COG2172	sigma factor antagonist activity
H3L99_RS19415	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H3L99_RS19425	COG2890	protein-(glutamine-N5) methyltransferase activity
H3L99_RS19435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H3L99_RS19435	COG1754	DNA topoisomerase type I activity
H3L99_RS19440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H3L99_RS19445	COG0470	DNA polymerase III
H3L99_RS19490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3L99_RS19510	COG0475	glutathione-regulated potassium exporter activity
H3L99_RS19520	COG0477	Major facilitator Superfamily
H3L99_RS19555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H3L99_RS19555	COG2070	2-Nitropropane dioxygenase
H3L99_RS19560	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS19600	COG0825	malonyl-CoA metabolic process
H3L99_RS19600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3L99_RS19605	COG0511	ligase activity, forming carbon-carbon bonds
H3L99_RS19610	COG0439	Biotin carboxylase
H3L99_RS19625	COG4865	methylaspartate mutase activity
H3L99_RS19630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L99_RS19635	COG0697	spore germination
H3L99_RS19640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H3L99_RS19645	COG0527	aspartate kinase activity
H3L99_RS19650	COG2175	clavaminate synthase activity
H3L99_RS19665	COG0583	DNA-binding transcription factor activity
H3L99_RS19675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3L99_RS19690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3L99_RS19690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3L99_RS19695	COG0110	maltose O-acetyltransferase activity
H3L99_RS19705	COG0577	efflux transmembrane transporter activity
H3L99_RS19710	COG0577	efflux transmembrane transporter activity
H3L99_RS19710	COG1136	(ABC) transporter
H3L99_RS19730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H3L99_RS19735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H3L99_RS19740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3L99_RS19745	COG0254	rRNA binding
H3L99_RS19755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H3L99_RS19775	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS19780	COG2318	DinB family
H3L99_RS19800	COG0076	glutamate decarboxylase activity
H3L99_RS19805	COG0789	Transcriptional regulator
H3L99_RS19810	COG0393	Putative heavy-metal-binding
H3L99_RS19815	COG0586	Pfam SNARE associated Golgi protein
H3L99_RS19825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H3L99_RS19830	COG2027	D-alanyl-D-alanine carboxypeptidase
H3L99_RS19840	COG0037	tRNA processing
H3L99_RS19855	COG0302	gtp cyclohydrolase
H3L99_RS19860	COG0667	Aldo Keto reductase
H3L99_RS19875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H3L99_RS19890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H3L99_RS19890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H3L99_RS19900	COG0517	IMP dehydrogenase activity
H3L99_RS19900	COG1125	glycine betaine transport
H3L99_RS19910	COG1174	glycine betaine transport
H3L99_RS19915	COG1732	Glycine betaine
H3L99_RS19925	COG0649	NAD binding
H3L99_RS19940	COG2197	response regulator
H3L99_RS19945	COG0640	Transcriptional regulator
H3L99_RS19965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H3L99_RS19970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H3L99_RS19980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H3L99_RS20000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H3L99_RS20020	COG2027	D-alanyl-D-alanine carboxypeptidase
H3L99_RS20025	COG0739	heme binding
H3L99_RS20030	COG2205	protein histidine kinase activity
H3L99_RS20035	COG0745	RESPONSE REGULATOR receiver
H3L99_RS20045	COG1595	DNA-templated transcription, initiation
H3L99_RS20050	COG1194	a g-specific adenine glycosylase
H3L99_RS20055	COG0671	phosphoesterase, PA-phosphatase related
H3L99_RS20065	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H3L99_RS20085	COG0248	Ppx GppA phosphatase
H3L99_RS20090	COG1082	Xylose isomerase domain protein TIM barrel
H3L99_RS20100	COG0129	dihydroxy-acid dehydratase activity
H3L99_RS20110	COG4991	sh3 domain protein
H3L99_RS20120	COG1129	ABC transporter
H3L99_RS20120	COG0842	Transport permease protein
H3L99_RS20130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H3L99_RS20135	COG0180	Tryptophanyl-tRNA synthetase
H3L99_RS20155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3L99_RS20165	COG0123	including yeast histone deacetylase and acetoin utilization protein
H3L99_RS20200	COG1595	DNA-templated transcription, initiation
H3L99_RS20215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H3L99_RS20220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H3L99_RS20225	COG0181	hydroxymethylbilane synthase activity
H3L99_RS20230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H3L99_RS20230	COG1648	precorrin-2 dehydrogenase activity
H3L99_RS20235	COG2226	methyltransferase
H3L99_RS20240	COG0113	porphobilinogen synthase activity
H3L99_RS20270	COG2272	Belongs to the type-B carboxylesterase lipase family
H3L99_RS20295	COG0018	arginyl-trna synthetase
H3L99_RS20300	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H3L99_RS20325	COG1690	Belongs to the RtcB family
H3L99_RS20345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3L99_RS20390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H3L99_RS20395	COG0406	alpha-ribazole phosphatase activity
H3L99_RS20405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3L99_RS20415	COG1333	cytochrome c biogenesis protein
H3L99_RS20420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H3L99_RS20435	COG0697	spore germination
H3L99_RS20440	COG0583	DNA-binding transcription factor activity
H3L99_RS20450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H3L99_RS20460	COG0109	protoheme IX farnesyltransferase activity
H3L99_RS20470	COG0163	prenyltransferase activity
H3L99_RS20485	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H3L99_RS20500	COG1301	dicarboxylic acid transport
H3L99_RS20515	COG1309	transcriptional regulator
H3L99_RS20540	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H3L99_RS20550	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H3L99_RS20560	COG2226	methyltransferase
H3L99_RS20565	COG2066	Belongs to the glutaminase family
H3L99_RS20595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H3L99_RS20635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3L99_RS20640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3L99_RS20645	COG0649	NAD binding
H3L99_RS20655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H3L99_RS20660	COG1034	ATP synthesis coupled electron transport
H3L99_RS20665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H3L99_RS20670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3L99_RS20675	COG0839	Belongs to the complex I subunit 6 family
H3L99_RS20680	COG0713	ATP synthesis coupled electron transport
H3L99_RS20685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H3L99_RS20695	COG1007	ATP synthesis coupled electron transport
H3L99_RS20700	COG2207	Transcriptional regulator
H3L99_RS20700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3L99_RS20730	COG1131	(ABC) transporter
H3L99_RS20740	COG2234	aminopeptidase activity
H3L99_RS20740	COG4935	Belongs to the peptidase S8 family
H3L99_RS20770	COG0702	epimerase
H3L99_RS20775	COG1733	regulation of RNA biosynthetic process
H3L99_RS20780	COG1013	pyruvate-flavodoxin oxidoreductase activity
H3L99_RS20785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H3L99_RS20785	COG0674	pyruvate-flavodoxin oxidoreductase activity
H3L99_RS20810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3L99_RS20815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3L99_RS20820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H3L99_RS20830	COG0839	Belongs to the complex I subunit 6 family
H3L99_RS20835	COG0713	ATP synthesis coupled electron transport
H3L99_RS20850	COG1007	ATP synthesis coupled electron transport
H3L99_RS20855	COG0501	Belongs to the peptidase M48B family
H3L99_RS20860	COG3304	Inner membrane component domain
H3L99_RS20870	COG2261	transglycosylase associated protein
H3L99_RS20880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3L99_RS20885	COG1666	GTP binding
H3L99_RS20915	COG0402	S-adenosylhomocysteine deaminase activity
H3L99_RS20930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3L99_RS20935	COG2030	dehydratase
H3L99_RS20950	COG0477	Major facilitator Superfamily
H3L99_RS20955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H3L99_RS20970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3L99_RS20985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H3L99_RS20995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H3L99_RS21010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H3L99_RS21015	COG0222	ribosome binding
H3L99_RS21020	COG0085	RNA polymerase activity
H3L99_RS21025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H3L99_RS21030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H3L99_RS21035	COG0049	tRNA binding
H3L99_RS21040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H3L99_RS21045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H3L99_RS21065	COG0051	transcription antitermination factor activity, RNA binding
H3L99_RS21070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H3L99_RS21075	COG0088	Forms part of the polypeptide exit tunnel
H3L99_RS21080	COG0089	rRNA binding
H3L99_RS21085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H3L99_RS21090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H3L99_RS21095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H3L99_RS21100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H3L99_RS21105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H3L99_RS21110	COG0255	Belongs to the universal ribosomal protein uL29 family
H3L99_RS21115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H3L99_RS21120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H3L99_RS21125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H3L99_RS21130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H3L99_RS21135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H3L99_RS21140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H3L99_RS21145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H3L99_RS21150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H3L99_RS21155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H3L99_RS21160	COG1841	ribosomal large subunit assembly
H3L99_RS21165	COG0200	Binds to the 23S rRNA
H3L99_RS21175	COG0563	adenylate kinase activity
H3L99_RS21185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H3L99_RS21190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H3L99_RS21195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H3L99_RS21205	COG0202	RNA polymerase activity
H3L99_RS21210	COG0203	ribosomal protein L17
H3L99_RS21215	COG0101	tRNA pseudouridine synthase activity
H3L99_RS21230	COG0488	(ABC) transporter
H3L99_RS21235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H3L99_RS21240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H3L99_RS21245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3L99_RS21255	COG1072	(Pantothenic acid kinase))
H3L99_RS21275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3L99_RS21280	COG0736	holo-[acyl-carrier-protein] synthase activity
H3L99_RS21290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H3L99_RS21300	COG0802	atpase or kinase
H3L99_RS21325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H3L99_RS21340	COG4941	Belongs to the sigma-70 factor family
H3L99_RS21395	COG0726	polysaccharide deacetylase
H3L99_RS21405	COG0459	protein refolding
H3L99_RS21415	COG4221	oxidoreductase activity
H3L99_RS21425	COG0583	DNA-binding transcription factor activity
H3L99_RS21440	COG1595	DNA-templated transcription, initiation
H3L99_RS21450	COG0516	GMP reductase activity
H3L99_RS21465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H3L99_RS21480	COG0515	serine threonine protein kinase
H3L99_RS21485	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS21505	COG0519	Catalyzes the synthesis of GMP from XMP
H3L99_RS21505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H3L99_RS21535	COG2197	response regulator
H3L99_RS21545	COG0791	NLP P60 protein
H3L99_RS21575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3L99_RS21595	COG0714	Associated with various cellular activities
H3L99_RS21600	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H3L99_RS21605	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H3L99_RS21620	COG0045	succinate-CoA ligase (ADP-forming) activity
H3L99_RS21650	COG0138	bifunctional purine biosynthesis protein purh
H3L99_RS21680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H3L99_RS21690	COG0538	isocitrate dehydrogenase activity
H3L99_RS21700	COG0039	L-malate dehydrogenase activity
H3L99_RS21735	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS21745	COG0517	IMP dehydrogenase activity
H3L99_RS21745	COG4175	Glycine betaine
H3L99_RS21750	COG4176	ABC-type proline glycine betaine transport system permease component
H3L99_RS21770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3L99_RS21780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3L99_RS21785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3L99_RS21800	COG1595	DNA-templated transcription, initiation
H3L99_RS21805	COG0180	Tryptophanyl-tRNA synthetase
H3L99_RS21830	COG1408	metallophosphoesterase
H3L99_RS21835	COG1309	transcriptional regulator
H3L99_RS21875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H3L99_RS21880	COG1053	succinate dehydrogenase
H3L99_RS21890	COG2009	succinate dehydrogenase
H3L99_RS21965	COG0681	Belongs to the peptidase S26 family
H3L99_RS22025	COG1595	DNA-templated transcription, initiation
H3L99_RS22060	COG1216	Glycosyl transferase, family 2
H3L99_RS22075	COG2089	acid synthase
H3L99_RS22085	COG1473	amidohydrolase
H3L99_RS22085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H3L99_RS22130	COG2814	Major facilitator Superfamily
H3L99_RS22135	COG0583	DNA-binding transcription factor activity
H3L99_RS22150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3L99_RS22175	COG2205	protein histidine kinase activity
H3L99_RS22180	COG0745	RESPONSE REGULATOR receiver
H3L99_RS22185	COG1595	DNA-templated transcription, initiation
H3L99_RS22205	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS22220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3L99_RS22250	COG4770	biotin carboxylase activity
H3L99_RS22260	COG0424	maF-like protein
H3L99_RS22280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3L99_RS22295	COG1024	Enoyl-CoA hydratase
H3L99_RS22305	COG2986	histidine ammonia-lyase
H3L99_RS22320	COG1376	ErfK ybiS ycfS ynhG family protein
H3L99_RS22340	COG0488	(ABC) transporter
H3L99_RS22355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3L99_RS22380	COG1595	DNA-templated transcription, initiation
H3L99_RS22390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H3L99_RS22405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H3L99_RS22415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H3L99_RS22430	COG0583	DNA-binding transcription factor activity
H3L99_RS22460	COG1331	Highly conserved protein containing a thioredoxin domain
H3L99_RS22475	COG0463	Glycosyl transferase, family 2
H3L99_RS22490	COG1309	transcriptional regulator
H3L99_RS22495	COG0477	Major facilitator Superfamily
H3L99_RS22505	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H3L99_RS22525	COG2890	protein-(glutamine-N5) methyltransferase activity
H3L99_RS22560	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS22575	COG0728	peptidoglycan biosynthetic process
H3L99_RS22585	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS22660	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H3L99_RS22675	COG1414	Transcriptional regulator
H3L99_RS22680	COG0251	oxidation-reduction process
H3L99_RS22685	COG2610	gluconate transmembrane transporter activity
H3L99_RS22725	COG0489	protein tyrosine kinase activity
H3L99_RS22765	COG2885	chlorophyll binding
H3L99_RS22795	COG0667	Aldo Keto reductase
H3L99_RS22800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3L99_RS22805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H3L99_RS22825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3L99_RS22830	COG0450	alkyl hydroperoxide reductase
H3L99_RS22845	COG1136	(ABC) transporter
H3L99_RS22860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3L99_RS22875	COG0114	fumarate hydratase activity
H3L99_RS22885	COG1595	DNA-templated transcription, initiation
H3L99_RS22895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H3L99_RS22895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H3L99_RS22930	COG0778	Nitroreductase
H3L99_RS22935	COG1722	exodeoxyribonuclease VII activity
H3L99_RS22940	COG1570	exodeoxyribonuclease VII activity
H3L99_RS22950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H3L99_RS22965	COG0012	GTP binding
H3L99_RS22970	COG4974	Belongs to the 'phage' integrase family
H3L99_RS23060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H3L99_RS23075	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS23125	COG1842	Phage shock protein A
H3L99_RS23170	COG4166	transmembrane transport
H3L99_RS23175	COG0601	transmembrane transport
H3L99_RS23180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3L99_RS23185	COG0444	Belongs to the ABC transporter superfamily
H3L99_RS23190	COG4608	Belongs to the ABC transporter superfamily
H3L99_RS23210	COG0601	transmembrane transport
H3L99_RS23215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3L99_RS23225	COG4608	Belongs to the ABC transporter superfamily
H3L99_RS23245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H3L99_RS23270	COG3209	COG3209 Rhs family protein
H3L99_RS23310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3L99_RS23315	COG1611	Belongs to the LOG family
H3L99_RS23320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H3L99_RS23330	COG2818	Glycosylase
H3L99_RS23335	COG1024	Enoyl-CoA hydratase
H3L99_RS23350	COG1595	DNA-templated transcription, initiation
H3L99_RS23365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H3L99_RS23400	COG0598	Magnesium transport protein CorA
H3L99_RS23420	COG2095	MarC family integral membrane protein
H3L99_RS23430	COG1432	Conserved Protein
H3L99_RS23440	COG0513	Belongs to the DEAD box helicase family
H3L99_RS23535	COG0210	DNA helicase
H3L99_RS23540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3L99_RS23580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H3L99_RS23635	COG3480	Lon protease (S16) C-terminal proteolytic domain
H3L99_RS23645	COG1615	UPF0182 protein
H3L99_RS23670	COG0753	catalase activity
H3L99_RS23680	COG0483	inositol monophosphate 1-phosphatase activity
H3L99_RS23690	COG2076	Multidrug Resistance protein
H3L99_RS23695	COG1162	GTPase activity
H3L99_RS23700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H3L99_RS23710	COG2135	peptidase activity
H3L99_RS23720	COG1595	DNA-templated transcription, initiation
H3L99_RS23725	COG5662	AntiSigma factor
H3L99_RS23730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H3L99_RS23730	COG2199	diguanylate cyclase activity
H3L99_RS23745	COG0242	peptide deformylase activity
H3L99_RS23780	COG2188	Transcriptional regulator
H3L99_RS23795	COG0395	ABC-type sugar transport system, permease component
H3L99_RS23800	COG1472	Belongs to the glycosyl hydrolase 3 family
H3L99_RS23820	COG1597	lipid kinase activity
H3L99_RS23850	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H3L99_RS23855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3L99_RS23875	COG5640	endopeptidase activity
H3L99_RS23920	COG4106	trans-aconitate 2-methyltransferase activity
H3L99_RS23925	COG1126	abc transporter atp-binding protein
H3L99_RS23930	COG0765	amino acid transport
H3L99_RS23950	COG3540	Alkaline phosphatase
H3L99_RS23955	COG0604	alcohol dehydrogenase
H3L99_RS24005	COG0567	Dehydrogenase, E1 component
H3L99_RS24005	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3L99_RS24010	COG2205	protein histidine kinase activity
H3L99_RS24015	COG0745	RESPONSE REGULATOR receiver
H3L99_RS24035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H3L99_RS24040	COG1357	PFAM Pentapeptide repeats (8 copies)
H3L99_RS24085	COG3883	PFAM NLP P60 protein
H3L99_RS24085	COG0791	NLP P60 protein
H3L99_RS24120	COG0768	penicillin binding
H3L99_RS24150	COG1793	dna ligase
H3L99_RS24150	COG3285	dna ligase
H3L99_RS24155	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H3L99_RS24185	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS24315	COG0018	arginyl-trna synthetase
H3L99_RS24320	COG0019	diaminopimelate decarboxylase activity
H3L99_RS24325	COG0460	homoserine dehydrogenase
H3L99_RS24330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H3L99_RS24335	COG0083	homoserine kinase activity
H3L99_RS24345	COG1316	TRANSCRIPTIONal
H3L99_RS24350	COG0254	rRNA binding
H3L99_RS24355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H3L99_RS24360	COG2890	protein-(glutamine-N5) methyltransferase activity
H3L99_RS24370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H3L99_RS24375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3L99_RS24395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3L99_RS24400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H3L99_RS24405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3L99_RS24410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H3L99_RS24415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H3L99_RS24420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H3L99_RS24425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H3L99_RS24440	COG2197	response regulator
H3L99_RS24460	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3L99_RS24470	COG1136	(ABC) transporter
H3L99_RS24530	COG0183	Belongs to the thiolase family
H3L99_RS24545	COG0745	RESPONSE REGULATOR receiver
H3L99_RS24550	COG2205	protein histidine kinase activity
H3L99_RS24620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3L99_RS24620	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3L99_RS24655	COG2188	Transcriptional regulator
H3L99_RS24670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H3L99_RS24675	COG0280	phosphate acetyltransferase
H3L99_RS24675	COG0857	belongs to the CobB CobQ family
H3L99_RS24680	COG0205	6-phosphofructokinase activity
H3L99_RS24705	COG0395	ABC-type sugar transport system, permease component
H3L99_RS24710	COG1175	transmembrane transport
H3L99_RS24720	COG4565	transcriptional regulatory protein
H3L99_RS24725	COG3290	protein histidine kinase activity
H3L99_RS24730	COG1301	dicarboxylic acid transport
H3L99_RS24740	COG3118	belongs to the thioredoxin family
H3L99_RS24745	COG1595	DNA-templated transcription, initiation
H3L99_RS24755	COG0745	RESPONSE REGULATOR receiver
H3L99_RS24770	COG3973	AAA domain
H3L99_RS24775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H3L99_RS24790	COG0366	Alpha amylase catalytic
H3L99_RS24795	COG0058	SHG alpha-glucan phosphorylase activity
H3L99_RS24850	COG2252	PERMEase
H3L99_RS24855	COG4585	Histidine kinase
H3L99_RS24875	COG1132	(ABC) transporter
H3L99_RS24880	COG1132	(ABC) transporter
H3L99_RS24885	COG1131	(ABC) transporter
H3L99_RS24895	COG4585	Histidine kinase
H3L99_RS24900	COG2197	response regulator
H3L99_RS24915	COG1376	ErfK ybiS ycfS ynhG family protein
H3L99_RS24925	COG0515	serine threonine protein kinase
H3L99_RS24935	COG1132	(ABC) transporter
H3L99_RS24940	COG1132	(ABC) transporter
H3L99_RS24945	COG2197	response regulator
H3L99_RS24970	COG1760	l-serine dehydratase
H3L99_RS24975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3L99_RS24980	COG0509	glycine decarboxylation via glycine cleavage system
H3L99_RS24985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H3L99_RS25005	COG0747	negative chemotaxis
H3L99_RS25020	COG0444	Belongs to the ABC transporter superfamily
H3L99_RS25025	COG4608	Belongs to the ABC transporter superfamily
H3L99_RS25030	COG2860	membrane
H3L99_RS25070	COG0482	sulfurtransferase activity
H3L99_RS25090	COG4221	oxidoreductase activity
H3L99_RS25100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3L99_RS25110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3L99_RS25115	COG0154	amidase activity
H3L99_RS25125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3L99_RS25145	COG2409	Drug exporters of the RND superfamily
H3L99_RS25150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H3L99_RS25175	COG2197	response regulator
H3L99_RS25185	COG2133	pyrroloquinoline quinone binding
H3L99_RS25190	COG0667	Aldo Keto reductase
H3L99_RS25210	COG0440	acetolactate synthase activity
H3L99_RS25215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H3L99_RS25220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H3L99_RS25235	COG0477	Major facilitator Superfamily
H3L99_RS25250	COG0506	proline dehydrogenase activity
H3L99_RS25255	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS25275	COG1695	Transcriptional regulator
H3L99_RS25280	COG0473	3-isopropylmalate dehydrogenase activity
H3L99_RS25285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H3L99_RS25295	COG0832	Belongs to the urease beta subunit family
H3L99_RS25295	COG0831	urea catabolic process
H3L99_RS25300	COG0804	urea catabolic process
H3L99_RS25305	COG2957	Belongs to the agmatine deiminase family
H3L99_RS25315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H3L99_RS25325	COG1609	Transcriptional regulator
H3L99_RS25330	COG1472	Belongs to the glycosyl hydrolase 3 family
H3L99_RS25345	COG2353	YceI-like domain
H3L99_RS25360	COG0366	Alpha amylase catalytic
H3L99_RS25360	COG1470	cell adhesion involved in biofilm formation
H3L99_RS25365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3L99_RS25395	COG2018	Roadblock/LC7 domain
H3L99_RS25415	COG2018	Roadblock/LC7 domain
H3L99_RS25420	COG5002	protein histidine kinase activity
H3L99_RS25430	COG0179	Fumarylacetoacetate (FAA) hydrolase
H3L99_RS25435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H3L99_RS25480	COG1414	Transcriptional regulator
H3L99_RS25485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H3L99_RS25490	COG0066	3-isopropylmalate dehydratase activity
H3L99_RS25500	COG0776	regulation of translation
H3L99_RS25510	COG1920	GTP binding
H3L99_RS25520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H3L99_RS25525	COG1181	Belongs to the D-alanine--D-alanine ligase family
H3L99_RS25545	COG0351	phosphomethylpyrimidine kinase
H3L99_RS25550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H3L99_RS25555	COG1461	Dihydroxyacetone kinase
H3L99_RS25565	COG0326	Molecular chaperone. Has ATPase activity
H3L99_RS25575	COG0742	ribosomal rna small subunit methyltransferase
H3L99_RS25580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H3L99_RS25595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H3L99_RS25600	COG0571	ribonuclease III activity
H3L99_RS25605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3L99_RS25620	COG2340	Cysteine-rich secretory protein family
H3L99_RS25625	COG1254	Belongs to the acylphosphatase family
H3L99_RS25635	COG1196	nuclear chromosome segregation
H3L99_RS25640	COG0477	Major facilitator Superfamily
H3L99_RS25650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H3L99_RS25680	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H3L99_RS25695	COG0442	prolyl-tRNA aminoacylation
H3L99_RS25705	COG0228	four-way junction DNA binding
H3L99_RS25710	COG1837	Belongs to the UPF0109 family
H3L99_RS25715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H3L99_RS25725	COG0335	large ribosomal subunit rRNA binding
H3L99_RS25730	COG0681	Belongs to the peptidase S26 family
H3L99_RS25740	COG0681	Belongs to the peptidase S26 family
H3L99_RS25745	COG0681	Belongs to the peptidase S26 family
H3L99_RS25760	COG0792	nuclease activity
H3L99_RS25775	COG1191	sigma factor activity
H3L99_RS25790	COG0052	Belongs to the universal ribosomal protein uS2 family
H3L99_RS25795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H3L99_RS25800	COG0528	UMP kinase activity
H3L99_RS25805	COG0233	cytoplasmic translational termination
H3L99_RS25810	COG0575	Belongs to the CDS family
H3L99_RS25825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H3L99_RS25840	COG3842	ATPase activity
H3L99_RS25855	COG1136	(ABC) transporter
H3L99_RS25860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H3L99_RS25870	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS25880	COG0300	oxidoreductase activity
H3L99_RS25885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H3L99_RS25890	COG2197	response regulator
H3L99_RS25895	COG4585	Histidine kinase
H3L99_RS25910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3L99_RS25930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H3L99_RS25935	COG3842	ATPase activity
H3L99_RS25940	COG1176	ABC-type spermidine putrescine transport system, permease component I
H3L99_RS25945	COG1177	transmembrane transport
H3L99_RS25950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3L99_RS25980	COG2508	Transcriptional regulator
H3L99_RS25985	COG0697	spore germination
H3L99_RS25990	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS26015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H3L99_RS26020	COG0750	zinc metalloprotease
H3L99_RS26025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H3L99_RS26040	COG0442	prolyl-tRNA aminoacylation
H3L99_RS26060	COG0779	Required for maturation of 30S ribosomal subunits
H3L99_RS26075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H3L99_RS26085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H3L99_RS26090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H3L99_RS26105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H3L99_RS26110	COG4608	Belongs to the ABC transporter superfamily
H3L99_RS26115	COG0444	Belongs to the ABC transporter superfamily
H3L99_RS26120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3L99_RS26125	COG0601	transmembrane transport
H3L99_RS26135	COG0455	bacterial-type flagellum organization
H3L99_RS26155	COG1404	Belongs to the peptidase S8 family
H3L99_RS26175	COG1674	ftsk spoiiie
H3L99_RS26185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H3L99_RS26190	COG1185	polyribonucleotide nucleotidyltransferase activity
H3L99_RS26195	COG0612	Peptidase, M16
H3L99_RS26200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H3L99_RS26220	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H3L99_RS26225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3L99_RS26230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H3L99_RS26255	COG2208	phosphoserine phosphatase activity
H3L99_RS26255	COG2770	Histidine kinase
H3L99_RS26260	COG2205	protein histidine kinase activity
H3L99_RS26260	COG0784	Response regulator, receiver
H3L99_RS26270	COG1674	ftsk spoiiie
H3L99_RS26280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H3L99_RS26290	COG1546	Belongs to the CinA family
H3L99_RS26290	COG1058	Belongs to the CinA family
H3L99_RS26295	COG1396	sequence-specific DNA binding
H3L99_RS26305	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS26310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3L99_RS26315	COG1201	RNA secondary structure unwinding
H3L99_RS26350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H3L99_RS26360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H3L99_RS26395	COG0765	amino acid transport
H3L99_RS26400	COG0765	amino acid transport
H3L99_RS26405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L99_RS26410	COG1126	abc transporter atp-binding protein
H3L99_RS26415	COG0745	RESPONSE REGULATOR receiver
H3L99_RS26420	COG2205	protein histidine kinase activity
H3L99_RS26430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H3L99_RS26450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H3L99_RS26460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H3L99_RS26465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3L99_RS26475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H3L99_RS26550	COG0488	(ABC) transporter
H3L99_RS26555	COG0588	phosphoglycerate mutase activity
H3L99_RS26575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H3L99_RS26610	COG1802	Transcriptional regulator
H3L99_RS26615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3L99_RS26630	COG0187	DNA topoisomerase II activity
H3L99_RS26635	COG4585	Histidine kinase
H3L99_RS26640	COG2197	response regulator
H3L99_RS26650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L99_RS26660	COG3290	protein histidine kinase activity
H3L99_RS26680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3L99_RS26685	COG0612	Peptidase, M16
H3L99_RS26700	COG1802	Transcriptional regulator
H3L99_RS26705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3L99_RS26725	COG1435	thymidine kinase activity
H3L99_RS26800	COG0745	RESPONSE REGULATOR receiver
H3L99_RS26805	COG2205	protein histidine kinase activity
H3L99_RS26830	COG0756	dUTP diphosphatase activity
H3L99_RS26840	COG1136	(ABC) transporter
H3L99_RS26840	COG4591	ABC-type transport system involved in lipoprotein release permease component
H3L99_RS26870	COG0569	domain protein
H3L99_RS26875	COG0531	amino acid
H3L99_RS26880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3L99_RS26890	COG0590	tRNA wobble adenosine to inosine editing
H3L99_RS26930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H3L99_RS26945	COG1215	transferase activity, transferring glycosyl groups
H3L99_RS26955	COG4310	Domain of unknown function (DUF2172)
H3L99_RS26970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H3L99_RS26980	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS27005	COG0367	asparagine synthase
H3L99_RS27025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H3L99_RS27030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3L99_RS27090	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H3L99_RS27130	COG0702	epimerase
H3L99_RS27140	COG3387	PFAM Glycoside hydrolase 15-related
H3L99_RS27170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H3L99_RS27175	COG1278	Cold shock
H3L99_RS27180	COG0513	Belongs to the DEAD box helicase family
H3L99_RS27205	COG0745	RESPONSE REGULATOR receiver
H3L99_RS27210	COG2205	protein histidine kinase activity
H3L99_RS27225	COG0640	Transcriptional regulator
H3L99_RS27235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H3L99_RS27240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H3L99_RS27245	COG1984	allophanate hydrolase subunit 2
H3L99_RS27260	COG0456	acetyltransferase
H3L99_RS27265	COG0477	Major facilitator Superfamily
H3L99_RS27275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H3L99_RS27305	COG1196	nuclear chromosome segregation
H3L99_RS27305	COG0741	lytic transglycosylase activity
H3L99_RS27305	COG0739	heme binding
H3L99_RS27355	COG2197	response regulator
H3L99_RS27375	COG2132	Multicopper oxidase
H3L99_RS27490	COG2867	negative regulation of translational initiation
H3L99_RS27490	COG2226	methyltransferase
H3L99_RS27505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3L99_RS27510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L99_RS27535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H3L99_RS27545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H3L99_RS27550	COG2192	nodulation
H3L99_RS27560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H3L99_RS27565	COG0859	PFAM glycosyl transferase family 9
H3L99_RS27575	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS27580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H3L99_RS27585	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H3L99_RS27585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H3L99_RS27590	COG0859	PFAM glycosyl transferase family 9
H3L99_RS27600	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS27605	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS27610	COG2723	6-phospho-beta-galactosidase activity
H3L99_RS27615	COG5297	Belongs to the glycosyl hydrolase family 6
H3L99_RS27615	COG3250	beta-galactosidase activity
H3L99_RS27635	COG1175	transmembrane transport
H3L99_RS27640	COG0395	ABC-type sugar transport system, permease component
H3L99_RS27645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3L99_RS27655	COG1609	Transcriptional regulator
H3L99_RS27660	COG2182	Extracellular solute-binding protein
H3L99_RS27665	COG1175	transmembrane transport
H3L99_RS27675	COG0366	Alpha amylase catalytic
H3L99_RS27695	COG1799	cell septum assembly
H3L99_RS27720	COG2040	homocysteine
H3L99_RS27730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H3L99_RS27790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3L99_RS27795	COG0531	amino acid
H3L99_RS27805	COG1024	Enoyl-CoA hydratase
H3L99_RS27850	COG2267	carboxylic ester hydrolase activity
H3L99_RS27865	COG1959	2 iron, 2 sulfur cluster binding
H3L99_RS27880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H3L99_RS27900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H3L99_RS27920	COG1653	transport
H3L99_RS27925	COG1175	transmembrane transport
H3L99_RS27930	COG0395	ABC-type sugar transport system, permease component
H3L99_RS27935	COG2267	carboxylic ester hydrolase activity
H3L99_RS27940	COG3226	Transcriptional regulator
H3L99_RS27955	COG1940	carbohydrate kinase activity
H3L99_RS27960	COG4213	ABC transporter substrate-binding protein
H3L99_RS27970	COG4214	carbohydrate transport
H3L99_RS27975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H3L99_RS27980	COG0531	amino acid
H3L99_RS28005	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS28015	COG0438	transferase activity, transferring glycosyl groups
H3L99_RS28030	COG0183	Belongs to the thiolase family
H3L99_RS28040	COG0583	DNA-binding transcription factor activity
H3L99_RS28060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H3L99_RS28070	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3L99_RS28090	COG0596	Alpha beta hydrolase
H3L99_RS28100	COG3220	belongs to the UPF0276 family
H3L99_RS28115	COG4977	sequence-specific DNA binding
H3L99_RS28145	COG4152	abc transporter atp-binding protein
H3L99_RS28190	COG1136	(ABC) transporter
H3L99_RS28200	COG1653	transport
H3L99_RS28215	COG1175	transmembrane transport
H3L99_RS28220	COG0395	ABC-type sugar transport system, permease component
H3L99_RS28225	COG1846	Transcriptional regulator
H3L99_RS28230	COG1764	response to oxidative stress
H3L99_RS28265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H3L99_RS28270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3L99_RS28280	COG2197	response regulator
H3L99_RS28285	COG4585	Histidine kinase
H3L99_RS28290	COG1131	(ABC) transporter
H3L99_RS28325	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H3L99_RS28325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3L99_RS28330	COG1073	alpha beta
H3L99_RS28390	COG4585	Histidine kinase
H3L99_RS28395	COG2197	response regulator
H3L99_RS28415	COG2318	DinB family
H3L99_RS28430	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H3L99_RS28435	COG3469	chitinase activity
H3L99_RS28505	COG0346	lactoylglutathione lyase activity
H3L99_RS28545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3L99_RS28550	COG0583	DNA-binding transcription factor activity
H3L99_RS28585	COG1175	transmembrane transport
H3L99_RS28610	COG2409	Drug exporters of the RND superfamily
H3L99_RS28625	COG2132	Multicopper oxidase
H3L99_RS28630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H3L99_RS28640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3L99_RS28645	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H3L99_RS28665	COG0529	Catalyzes the synthesis of activated sulfate
H3L99_RS28670	COG0175	sulfate reduction
H3L99_RS28680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H3L99_RS28695	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS28720	COG5002	protein histidine kinase activity
H3L99_RS28725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H3L99_RS28730	COG1733	regulation of RNA biosynthetic process
H3L99_RS28735	COG2130	NADP-dependent
H3L99_RS28740	COG1063	alcohol dehydrogenase
H3L99_RS28820	COG2304	oxidoreductase activity
H3L99_RS28835	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H3L99_RS28835	COG1796	DNA polymerase
H3L99_RS28845	COG1162	GTPase activity
H3L99_RS28860	COG1404	Belongs to the peptidase S8 family
H3L99_RS28870	COG0028	Belongs to the TPP enzyme family
H3L99_RS28890	COG1802	Transcriptional regulator
H3L99_RS28925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS28930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS28935	COG1120	ATPase activity
H3L99_RS28965	COG1132	(ABC) transporter
H3L99_RS28985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H3L99_RS28990	COG2252	PERMEase
H3L99_RS29050	COG2326	polyphosphate kinase activity
H3L99_RS29060	COG2197	response regulator
H3L99_RS29065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3L99_RS29070	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS29085	COG3960	tartronate-semialdehyde synthase activity
H3L99_RS29095	COG0753	catalase activity
H3L99_RS29100	COG2084	Dehydrogenase
H3L99_RS29105	COG3622	Belongs to the hyi family
H3L99_RS29155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H3L99_RS29195	COG2351	hydroxyisourate hydrolase activity
H3L99_RS29205	COG2233	PERMEase
H3L99_RS29215	COG2233	PERMEase
H3L99_RS29225	COG1063	alcohol dehydrogenase
H3L99_RS29230	COG2356	endonuclease I
H3L99_RS29260	COG2249	NAD(P)H dehydrogenase (quinone) activity
H3L99_RS29310	COG2272	Belongs to the type-B carboxylesterase lipase family
H3L99_RS29320	COG3866	Pectate lyase
H3L99_RS29335	COG0745	RESPONSE REGULATOR receiver
H3L99_RS29340	COG2205	protein histidine kinase activity
H3L99_RS29345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3L99_RS29345	COG0515	serine threonine protein kinase
H3L99_RS29350	COG2340	Cysteine-rich secretory protein family
H3L99_RS29360	COG2318	DinB family
H3L99_RS29390	COG2208	phosphoserine phosphatase activity
H3L99_RS29405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3L99_RS29405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3L99_RS29430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3L99_RS29435	COG2367	Beta-lactamase
H3L99_RS29470	COG3291	Pkd domain containing protein
H3L99_RS29470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H3L99_RS29495	COG0628	permease
H3L99_RS29535	COG3119	arylsulfatase activity
H3L99_RS29540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H3L99_RS29555	COG0714	Associated with various cellular activities
H3L99_RS29565	COG0477	Major facilitator Superfamily
H3L99_RS29575	COG4977	sequence-specific DNA binding
H3L99_RS29610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3L99_RS29695	COG1733	regulation of RNA biosynthetic process
H3L99_RS29705	COG0154	amidase activity
H3L99_RS29710	COG2226	methyltransferase
H3L99_RS29720	COG1733	regulation of RNA biosynthetic process
H3L99_RS29730	COG2267	carboxylic ester hydrolase activity
H3L99_RS29770	COG2197	response regulator
H3L99_RS29795	COG1414	Transcriptional regulator
H3L99_RS29800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3L99_RS29805	COG4266	Belongs to the allantoicase family
H3L99_RS29810	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS29840	COG2197	response regulator
H3L99_RS29860	COG0673	inositol 2-dehydrogenase activity
H3L99_RS29865	COG2188	Transcriptional regulator
H3L99_RS29870	COG1879	ABC-type sugar transport system periplasmic component
H3L99_RS29940	COG0739	heme binding
H3L99_RS30035	COG1132	(ABC) transporter
H3L99_RS30060	COG1126	abc transporter atp-binding protein
H3L99_RS30075	COG0405	Gamma-glutamyltransferase
H3L99_RS30105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3L99_RS30110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3L99_RS30120	COG1953	Uracil, thiamine, allantoin
H3L99_RS30130	COG0300	oxidoreductase activity
H3L99_RS30155	COG4585	Histidine kinase
H3L99_RS30160	COG2197	response regulator
H3L99_RS30170	COG1846	Transcriptional regulator
H3L99_RS30180	COG2986	histidine ammonia-lyase
H3L99_RS30190	COG0405	Gamma-glutamyltransferase
H3L99_RS30195	COG0483	inositol monophosphate 1-phosphatase activity
H3L99_RS30225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3L99_RS30230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H3L99_RS30240	COG0494	nUDIX hydrolase
H3L99_RS30260	COG0559	Belongs to the binding-protein-dependent transport system permease family
H3L99_RS30285	COG0688	phosphatidylethanolamine metabolic process
H3L99_RS30290	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS30305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3L99_RS30305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3L99_RS30310	COG0604	alcohol dehydrogenase
H3L99_RS30320	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3L99_RS30330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3L99_RS30340	COG0745	RESPONSE REGULATOR receiver
H3L99_RS30350	COG0659	secondary active sulfate transmembrane transporter activity
H3L99_RS30375	COG2814	Major facilitator Superfamily
H3L99_RS30420	COG1834	amidinotransferase
H3L99_RS30425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3L99_RS30430	COG2362	D-Aminopeptidase
H3L99_RS30435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3L99_RS30440	COG4946	Tricorn protease homolog
H3L99_RS30440	COG0823	Involved in the tonB-independent uptake of proteins
H3L99_RS30440	COG1506	peptidase
H3L99_RS30445	COG1619	proteins homologs of microcin C7 resistance protein MccF
H3L99_RS30450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3L99_RS30475	COG2226	methyltransferase
H3L99_RS30500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H3L99_RS30510	COG0531	amino acid
H3L99_RS30550	COG1793	dna ligase
H3L99_RS30560	COG2154	pterin-4-alpha-carbinolamine dehydratase
H3L99_RS30585	COG0656	L-ascorbic acid biosynthetic process
H3L99_RS30640	COG0477	Major facilitator Superfamily
H3L99_RS30650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H3L99_RS30665	COG3383	formate dehydrogenase (NAD+) activity
H3L99_RS30670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H3L99_RS30675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3L99_RS30700	COG1940	carbohydrate kinase activity
H3L99_RS30705	COG1129	ABC transporter
H3L99_RS30710	COG1172	Belongs to the binding-protein-dependent transport system permease family
H3L99_RS30715	COG4213	ABC transporter substrate-binding protein
H3L99_RS30720	COG0673	inositol 2-dehydrogenase activity
H3L99_RS30780	COG0789	Transcriptional regulator
H3L99_RS30790	COG2223	nitrite transmembrane transporter activity
H3L99_RS30800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3L99_RS30810	COG0045	succinate-CoA ligase (ADP-forming) activity
H3L99_RS30820	COG1012	belongs to the aldehyde dehydrogenase family
H3L99_RS30860	COG1129	ABC transporter
H3L99_RS30865	COG1879	ABC-type sugar transport system periplasmic component
H3L99_RS30870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3L99_RS30875	COG1869	D-ribose catabolic process
H3L99_RS30895	COG4977	sequence-specific DNA binding
H3L99_RS30945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3L99_RS30965	COG3938	Belongs to the proline racemase family
H3L99_RS30975	COG1595	DNA-templated transcription, initiation
H3L99_RS31005	COG3401	FG-GAP repeat protein
H3L99_RS31080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H3L99_RS31125	COG1132	(ABC) transporter
H3L99_RS31200	COG0515	serine threonine protein kinase
H3L99_RS31200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3L99_RS31220	COG0789	Transcriptional regulator
H3L99_RS31230	COG0789	Transcriptional regulator
H3L99_RS31265	COG0583	DNA-binding transcription factor activity
H3L99_RS31275	COG2855	membrane
H3L99_RS31305	COG0477	Major facilitator Superfamily
H3L99_RS31320	COG0583	DNA-binding transcription factor activity
H3L99_RS31325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H3L99_RS31330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H3L99_RS31335	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3L99_RS31410	COG1396	sequence-specific DNA binding
H3L99_RS31420	COG2318	DinB family
H3L99_RS31450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H3L99_RS31455	COG0477	Major facilitator Superfamily
H3L99_RS31475	COG0431	NADPH-dependent FMN reductase
H3L99_RS31505	COG1486	melibiose metabolic process
H3L99_RS31515	COG3012	SEC-C Motif Domain Protein
H3L99_RS31550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H3L99_RS31610	COG1793	dna ligase
H3L99_RS31615	COG3285	dna ligase
H3L99_RS31615	COG1793	dna ligase
H3L99_RS31640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3L99_RS31650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3L99_RS31695	COG3415	Transposase
H3L99_RS31695	COG2801	Transposase and inactivated derivatives
H3L99_RS31705	COG0488	(ABC) transporter
H3L99_RS31735	COG1515	deoxyribonuclease V activity
H3L99_RS31745	COG3268	Saccharopine dehydrogenase
H3L99_RS31755	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS31760	COG0183	Belongs to the thiolase family
H3L99_RS31765	COG1024	Enoyl-CoA hydratase
H3L99_RS31765	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3L99_RS31775	COG0789	Transcriptional regulator
H3L99_RS31800	COG3568	Endonuclease Exonuclease Phosphatase
H3L99_RS31820	COG0395	ABC-type sugar transport system, permease component
H3L99_RS31850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H3L99_RS31875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3L99_RS31880	COG0444	Belongs to the ABC transporter superfamily
H3L99_RS31885	COG4608	Belongs to the ABC transporter superfamily
H3L99_RS31910	COG2183	response to ionizing radiation
H3L99_RS31930	COG4977	sequence-specific DNA binding
H3L99_RS31940	COG1024	Enoyl-CoA hydratase
H3L99_RS31955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H3L99_RS31985	COG0371	Dehydrogenase
H3L99_RS32005	COG1134	teichoic acid transport
H3L99_RS32005	COG1388	LysM domain
H3L99_RS32010	COG1562	ergosterol biosynthetic process
H3L99_RS32020	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H3L99_RS32030	COG1657	PFAM Prenyltransferase squalene oxidase
H3L99_RS32075	COG2755	lipolytic protein G-D-S-L family
H3L99_RS32085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H3L99_RS32120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3L99_RS32160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3L99_RS32170	COG1116	anion transmembrane transporter activity
H3L99_RS32180	COG3507	Belongs to the glycosyl hydrolase 43 family
H3L99_RS32210	COG3958	Transketolase
H3L99_RS32215	COG3959	Transketolase, thiamine diphosphate binding domain
H3L99_RS32225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H3L99_RS32255	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H3L99_RS32260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3L99_RS32275	COG1132	(ABC) transporter
H3L99_RS32285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS32290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3L99_RS32295	COG1120	ATPase activity
H3L99_RS32315	COG1280	lysine exporter protein (LysE YggA)
H3L99_RS32340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H3L99_RS32400	COG1070	Carbohydrate kinase
H3L99_RS32415	COG1175	transmembrane transport
H3L99_RS32420	COG0395	ABC-type sugar transport system, permease component
H3L99_RS32430	COG3896	Chloramphenicol phosphotransferase-like protein
H3L99_RS32435	COG1609	Transcriptional regulator
H3L99_RS32445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H3L99_RS32445	COG0515	serine threonine protein kinase
H3L99_RS32545	COG5297	Belongs to the glycosyl hydrolase family 6
H3L99_RS32545	COG4733	cellulase activity
H3L99_RS32550	COG5297	Belongs to the glycosyl hydrolase family 6
H3L99_RS32560	COG1595	DNA-templated transcription, initiation
H3L99_RS32575	COG4677	pectinesterase activity
H3L99_RS32580	COG3866	Pectate lyase
H3L99_RS32585	COG2755	lipolytic protein G-D-S-L family
H3L99_RS32590	COG1653	transport
H3L99_RS32610	COG0395	ABC-type sugar transport system, permease component
H3L99_RS32615	COG1175	transmembrane transport
H3L99_RS32630	COG1802	Transcriptional regulator
H3L99_RS32645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3L99_RS32680	COG1733	regulation of RNA biosynthetic process
H3L99_RS32690	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS32705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H3L99_RS32710	COG1881	PFAM PEBP family protein
H3L99_RS32725	COG2207	Transcriptional regulator
H3L99_RS32725	COG3708	Transcriptional regulator
H3L99_RS32750	COG3903	Transcriptional regulator
H3L99_RS32750	COG3629	intracellular signal transduction
H3L99_RS32770	COG1595	DNA-templated transcription, initiation
H3L99_RS32805	COG0284	orotidine-5'-phosphate decarboxylase activity
H3L99_RS32845	COG1733	regulation of RNA biosynthetic process
H3L99_RS32850	COG1846	Transcriptional regulator
H3L99_RS32865	COG3655	Transcriptional regulator
H3L99_RS32880	COG0456	acetyltransferase
H3L99_RS32900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H3L99_RS32900	COG1796	DNA polymerase
H3L99_RS32910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3L99_RS32920	COG2271	Major facilitator Superfamily
H3L99_RS32925	COG2175	clavaminate synthase activity
H3L99_RS32935	COG3246	L-lysine catabolic process to acetate
H3L99_RS32945	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS32950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H3L99_RS32965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H3L99_RS32985	COG0395	ABC-type sugar transport system, permease component
H3L99_RS32990	COG1063	alcohol dehydrogenase
H3L99_RS33065	COG3618	amidohydrolase
H3L99_RS33070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3L99_RS33095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L99_RS33150	COG2267	carboxylic ester hydrolase activity
H3L99_RS33170	COG0583	DNA-binding transcription factor activity
H3L99_RS33180	COG1053	succinate dehydrogenase
H3L99_RS33185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H3L99_RS33190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H3L99_RS33205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3L99_RS33215	COG3360	Dodecin
H3L99_RS33220	COG2188	Transcriptional regulator
H3L99_RS33225	COG2409	Drug exporters of the RND superfamily
H3L99_RS33235	COG2197	response regulator
H3L99_RS33240	COG4585	Histidine kinase
H3L99_RS33255	COG2188	Transcriptional regulator
H3L99_RS33260	COG2182	Extracellular solute-binding protein
H3L99_RS33265	COG1175	transmembrane transport
H3L99_RS33270	COG0395	ABC-type sugar transport system, permease component
H3L99_RS33275	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H3L99_RS33285	COG2182	Extracellular solute-binding protein
H3L99_RS33300	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H3L99_RS33305	COG0121	glutamine amidotransferase
H3L99_RS33310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H3L99_RS33335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3L99_RS33395	COG2851	Citrate transporter
H3L99_RS33410	COG1082	Xylose isomerase domain protein TIM barrel
H3L99_RS33415	COG0473	3-isopropylmalate dehydrogenase activity
H3L99_RS33420	COG3395	kinase activity
H3L99_RS33425	COG0235	Class ii aldolase
H3L99_RS33450	COG0148	phosphopyruvate hydratase activity
H3L99_RS33465	COG1595	DNA-templated transcription, initiation
H3L99_RS33470	COG3387	PFAM Glycoside hydrolase 15-related
H3L99_RS33475	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H3L99_RS33495	COG0455	bacterial-type flagellum organization
H3L99_RS33570	COG0346	lactoylglutathione lyase activity
H3L99_RS33575	COG0640	Transcriptional regulator
H3L99_RS33580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H3L99_RS33585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3L99_RS33605	COG0523	cobalamin synthesis protein
H3L99_RS33670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H3L99_RS33685	COG0110	maltose O-acetyltransferase activity
H3L99_RS33690	COG3226	Transcriptional regulator
H3L99_RS33695	COG0598	Magnesium transport protein CorA
H3L99_RS33740	COG0583	DNA-binding transcription factor activity
H3L99_RS33795	COG1733	regulation of RNA biosynthetic process
H3L99_RS33835	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS33885	COG0328	RNA-DNA hybrid ribonuclease activity
H3L99_RS33890	COG1619	proteins homologs of microcin C7 resistance protein MccF
H3L99_RS33910	COG0494	nUDIX hydrolase
H3L99_RS33965	COG2255	four-way junction helicase activity
H3L99_RS33975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H3L99_RS33995	COG1653	transport
H3L99_RS34000	COG1175	transmembrane transport
H3L99_RS34005	COG0395	ABC-type sugar transport system, permease component
H3L99_RS34010	COG0366	Alpha amylase catalytic
H3L99_RS34015	COG2723	6-phospho-beta-galactosidase activity
H3L99_RS34020	COG0395	ABC-type sugar transport system, permease component
H3L99_RS34025	COG1175	transmembrane transport
H3L99_RS34035	COG1940	carbohydrate kinase activity
H3L99_RS34095	COG1609	Transcriptional regulator
H3L99_RS34110	COG1879	ABC-type sugar transport system periplasmic component
H3L99_RS34115	COG1129	ABC transporter
H3L99_RS34125	COG1172	Belongs to the binding-protein-dependent transport system permease family
H3L99_RS34150	COG1755	Isoprenylcysteine carboxyl methyltransferase
H3L99_RS34155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3L99_RS34165	COG1032	radical SAM domain protein
H3L99_RS34170	COG0181	hydroxymethylbilane synthase activity
H3L99_RS34180	COG1733	regulation of RNA biosynthetic process
H3L99_RS34200	COG1609	Transcriptional regulator
H3L99_RS34205	COG3250	beta-galactosidase activity
H3L99_RS34215	COG1175	transmembrane transport
H3L99_RS34225	COG1132	(ABC) transporter
H3L99_RS34245	COG1874	Beta-galactosidase
H3L99_RS34245	COG0366	Alpha amylase catalytic
H3L99_RS34275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H3L99_RS34285	COG1090	epimerase
H3L99_RS34300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H3L99_RS34320	COG2208	phosphoserine phosphatase activity
H3L99_RS34340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H3L99_RS34350	COG0300	oxidoreductase activity
H3L99_RS34355	COG3540	Alkaline phosphatase
H3L99_RS34375	COG1309	transcriptional regulator
H3L99_RS34385	COG1473	amidohydrolase
H3L99_RS34395	COG0673	inositol 2-dehydrogenase activity
H3L99_RS34405	COG1349	DNA-binding transcription factor activity
H3L99_RS34410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3L99_RS34420	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS34430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H3L99_RS34450	COG1609	Transcriptional regulator
H3L99_RS34455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H3L99_RS34485	COG4989	oxidoreductase activity
H3L99_RS34510	COG3458	cephalosporin-C deacetylase activity
H3L99_RS34540	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS34545	COG1960	acyl-CoA dehydrogenase activity
H3L99_RS34555	COG0601	transmembrane transport
H3L99_RS34560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3L99_RS34565	COG0444	Belongs to the ABC transporter superfamily
H3L99_RS34570	COG1124	(ABC) transporter
H3L99_RS34605	COG3239	Fatty acid desaturase
H3L99_RS34660	COG2018	Roadblock/LC7 domain
H3L99_RS34670	COG1063	alcohol dehydrogenase
H3L99_RS34675	COG0156	8-amino-7-oxononanoate synthase activity
H3L99_RS34680	COG0583	DNA-binding transcription factor activity
H3L99_RS34710	COG2814	Major facilitator Superfamily
H3L99_RS34720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3L99_RS34720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3L99_RS34730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L99_RS34735	COG0765	amino acid transport
H3L99_RS34775	COG1309	transcriptional regulator
H3L99_RS34805	COG0596	Alpha beta hydrolase
H3L99_RS34820	COG3693	PFAM glycoside hydrolase, family 10
H3L99_RS34840	COG2226	methyltransferase
H3L99_RS34875	COG0804	urea catabolic process
H3L99_RS34900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3L99_RS34905	COG1024	Enoyl-CoA hydratase
H3L99_RS34915	COG1309	transcriptional regulator
H3L99_RS34930	COG0183	Belongs to the thiolase family
H3L99_RS34935	COG2030	dehydratase
H3L99_RS34945	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS34950	COG0318	PFAM AMP-dependent synthetase and ligase
H3L99_RS34960	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS34970	COG1309	transcriptional regulator
H3L99_RS34975	COG1472	Belongs to the glycosyl hydrolase 3 family
H3L99_RS34985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3L99_RS34985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3L99_RS34990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3L99_RS35005	COG4770	biotin carboxylase activity
H3L99_RS35035	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS35040	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS35050	COG1309	transcriptional regulator
H3L99_RS35065	COG0463	Glycosyl transferase, family 2
H3L99_RS35110	COG1609	Transcriptional regulator
H3L99_RS35150	COG1982	Orn Lys Arg decarboxylase major
H3L99_RS35160	COG1028	Short-chain dehydrogenase reductase Sdr
H3L99_RS35185	COG0346	lactoylglutathione lyase activity
H3L99_RS35200	COG0277	FAD linked oxidase domain protein
H3L99_RS35255	COG0667	Aldo Keto reductase
H3L99_RS35260	COG0531	amino acid
H3L99_RS35280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H3L99_RS35305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity