locus-tag	class	description
A4E84_RS00005	COG1595	DNA-templated transcription, initiation
A4E84_RS00055	COG2319	Wd-40 repeat
A4E84_RS00310	COG3328	transposase activity
A4E84_RS00325	COG2319	Wd-40 repeat
A4E84_RS00325	COG4249	Peptidase C14 caspase catalytic subunit p20
A4E84_RS00480	COG4974	Belongs to the 'phage' integrase family
A4E84_RS00565	COG2197	response regulator
A4E84_RS00575	COG2072	flavoprotein involved in K transport
A4E84_RS00600	COG0583	DNA-binding transcription factor activity
A4E84_RS00620	COG1846	Transcriptional regulator
A4E84_RS00630	COG0604	alcohol dehydrogenase
A4E84_RS00655	COG1609	Transcriptional regulator
A4E84_RS00665	COG0673	inositol 2-dehydrogenase activity
A4E84_RS00705	COG0667	Aldo Keto reductase
A4E84_RS00720	COG2234	aminopeptidase activity
A4E84_RS00765	COG1404	Belongs to the peptidase S8 family
A4E84_RS00770	COG2319	Wd-40 repeat
A4E84_RS00770	COG4249	Peptidase C14 caspase catalytic subunit p20
A4E84_RS00775	COG0726	polysaccharide deacetylase
A4E84_RS00840	COG0183	Belongs to the thiolase family
A4E84_RS00845	COG1309	transcriptional regulator
A4E84_RS00855	COG1024	Enoyl-CoA hydratase
A4E84_RS00860	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS00885	COG1024	Enoyl-CoA hydratase
A4E84_RS00895	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS00900	COG2188	Transcriptional regulator
A4E84_RS00910	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4E84_RS00920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4E84_RS00975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4E84_RS00985	COG3842	ATPase activity
A4E84_RS00990	COG1178	ABC-type Fe3 transport system permease component
A4E84_RS01000	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS01055	COG0395	ABC-type sugar transport system, permease component
A4E84_RS01070	COG1609	Transcriptional regulator
A4E84_RS01080	COG1846	Transcriptional regulator
A4E84_RS01085	COG2234	aminopeptidase activity
A4E84_RS01085	COG4935	Belongs to the peptidase S8 family
A4E84_RS01100	COG2192	nodulation
A4E84_RS01135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4E84_RS01140	COG1131	(ABC) transporter
A4E84_RS01150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4E84_RS01155	COG0076	glutamate decarboxylase activity
A4E84_RS01175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4E84_RS01195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4E84_RS01225	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A4E84_RS01280	COG0523	cobalamin synthesis protein
A4E84_RS01290	COG1132	(ABC) transporter
A4E84_RS01295	COG1132	(ABC) transporter
A4E84_RS01320	COG1120	ATPase activity
A4E84_RS01325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4E84_RS01355	COG1011	Hydrolase
A4E84_RS01370	COG0596	Alpha beta hydrolase
A4E84_RS01370	COG2945	thiolester hydrolase activity
A4E84_RS01390	COG0589	response to stress
A4E84_RS01410	COG1024	Enoyl-CoA hydratase
A4E84_RS01415	COG2045	Belongs to the ComB family
A4E84_RS01435	COG2329	Antibiotic biosynthesis monooxygenase
A4E84_RS01470	COG0411	ABC transporter
A4E84_RS01475	COG0410	ABC transporter
A4E84_RS01480	COG2508	Transcriptional regulator
A4E84_RS01505	COG5640	endopeptidase activity
A4E84_RS01510	COG1280	lysine exporter protein (LysE YggA)
A4E84_RS01520	COG0308	aminopeptidase N
A4E84_RS01530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4E84_RS01550	COG3851	Histidine kinase
A4E84_RS01555	COG2197	response regulator
A4E84_RS01565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4E84_RS01570	COG1819	glycosyl
A4E84_RS01615	COG1090	epimerase
A4E84_RS01690	COG2409	Drug exporters of the RND superfamily
A4E84_RS01725	COG3397	chitin binding
A4E84_RS01730	COG0456	acetyltransferase
A4E84_RS01735	COG1295	ribonuclease BN
A4E84_RS01790	COG3540	Alkaline phosphatase
A4E84_RS01840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4E84_RS01840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4E84_RS01845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4E84_RS01850	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS01860	COG0859	PFAM glycosyl transferase family 9
A4E84_RS01865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4E84_RS01875	COG2192	nodulation
A4E84_RS01880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4E84_RS01910	COG0753	catalase activity
A4E84_RS01955	COG2124	cytochrome p450
A4E84_RS01965	COG0009	L-threonylcarbamoyladenylate synthase
A4E84_RS02000	COG0656	L-ascorbic acid biosynthetic process
A4E84_RS02025	COG2207	Transcriptional regulator
A4E84_RS02030	COG2223	nitrite transmembrane transporter activity
A4E84_RS02040	COG3285	dna ligase
A4E84_RS02040	COG1793	dna ligase
A4E84_RS02055	COG0181	hydroxymethylbilane synthase activity
A4E84_RS02110	COG0366	Alpha amylase catalytic
A4E84_RS02125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4E84_RS02130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4E84_RS02160	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS02165	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS02170	COG2172	sigma factor antagonist activity
A4E84_RS02190	COG1252	NADH dehydrogenase
A4E84_RS02280	COG3189	MarR family transcriptional regulator
A4E84_RS02300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4E84_RS02325	COG3852	Histidine kinase
A4E84_RS02335	COG1672	PFAM Archaeal ATPase
A4E84_RS02335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4E84_RS02345	COG2340	Cysteine-rich secretory protein family
A4E84_RS02365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4E84_RS02370	COG0515	serine threonine protein kinase
A4E84_RS02380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS02415	COG0667	Aldo Keto reductase
A4E84_RS02435	COG2304	oxidoreductase activity
A4E84_RS02440	COG0328	RNA-DNA hybrid ribonuclease activity
A4E84_RS02460	COG0596	Alpha beta hydrolase
A4E84_RS02465	COG0740	serine-type endopeptidase activity
A4E84_RS02470	COG0740	serine-type endopeptidase activity
A4E84_RS02475	COG1396	sequence-specific DNA binding
A4E84_RS02480	COG1191	sigma factor activity
A4E84_RS02510	COG2815	serine threonine protein kinase
A4E84_RS02510	COG0515	serine threonine protein kinase
A4E84_RS02520	COG1131	(ABC) transporter
A4E84_RS02520	COG0842	Transport permease protein
A4E84_RS02520	COG1716	ATPase activity
A4E84_RS02535	COG0667	Aldo Keto reductase
A4E84_RS02540	COG0583	DNA-binding transcription factor activity
A4E84_RS02555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4E84_RS02560	COG0346	lactoylglutathione lyase activity
A4E84_RS02575	COG0667	Aldo Keto reductase
A4E84_RS02675	COG0589	response to stress
A4E84_RS02700	COG1024	Enoyl-CoA hydratase
A4E84_RS02715	COG0596	Alpha beta hydrolase
A4E84_RS02725	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS02735	COG2070	2-Nitropropane dioxygenase
A4E84_RS02740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4E84_RS02750	COG0515	serine threonine protein kinase
A4E84_RS02765	COG4171	peptide transport system, permease
A4E84_RS02770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4E84_RS02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4E84_RS02785	COG1177	transmembrane transport
A4E84_RS02795	COG3842	ATPase activity
A4E84_RS02810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4E84_RS02845	COG0730	response to heat
A4E84_RS02850	COG1937	Protein conserved in bacteria
A4E84_RS02860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4E84_RS02860	COG0574	Belongs to the PEP-utilizing enzyme family
A4E84_RS02880	COG1063	alcohol dehydrogenase
A4E84_RS02960	COG4948	Mandelate Racemase Muconate Lactonizing
A4E84_RS02985	COG1940	carbohydrate kinase activity
A4E84_RS02985	COG1846	Transcriptional regulator
A4E84_RS02990	COG1830	Aldolase
A4E84_RS03000	COG0205	6-phosphofructokinase activity
A4E84_RS03010	COG2132	Multicopper oxidase
A4E84_RS03065	COG0517	IMP dehydrogenase activity
A4E84_RS03065	COG0516	GMP reductase activity
A4E84_RS03085	COG0071	Belongs to the small heat shock protein (HSP20) family
A4E84_RS03120	COG1063	alcohol dehydrogenase
A4E84_RS03125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4E84_RS03130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4E84_RS03135	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4E84_RS03135	COG0022	dehydrogenase e1 component
A4E84_RS03140	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4E84_RS03155	COG4109	DRTGG domain
A4E84_RS03190	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4E84_RS03195	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A4E84_RS03215	COG0569	domain protein
A4E84_RS03220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4E84_RS03230	COG0589	response to stress
A4E84_RS03240	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS03255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4E84_RS03255	COG1042	CoA-binding domain protein
A4E84_RS03255	COG0045	succinate-CoA ligase (ADP-forming) activity
A4E84_RS03275	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS03345	COG2208	phosphoserine phosphatase activity
A4E84_RS03350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4E84_RS03360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4E84_RS03435	COG2376	Dihydroxyacetone kinase
A4E84_RS03440	COG1461	Dihydroxyacetone kinase
A4E84_RS03445	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A4E84_RS03455	COG4733	cellulase activity
A4E84_RS03455	COG5297	Belongs to the glycosyl hydrolase family 6
A4E84_RS03470	COG1902	pentaerythritol trinitrate reductase activity
A4E84_RS03470	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4E84_RS03485	COG2890	protein-(glutamine-N5) methyltransferase activity
A4E84_RS03495	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4E84_RS03510	COG3458	cephalosporin-C deacetylase activity
A4E84_RS03515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4E84_RS03530	COG2226	methyltransferase
A4E84_RS03535	COG1695	Transcriptional regulator
A4E84_RS03545	COG2226	methyltransferase
A4E84_RS03550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4E84_RS03560	COG1051	belongs to the nudix hydrolase family
A4E84_RS03570	COG2066	Belongs to the glutaminase family
A4E84_RS03585	COG1113	amino acid transport
A4E84_RS03590	COG2186	Transcriptional regulator
A4E84_RS03595	COG1968	undecaprenyl-diphosphatase activity
A4E84_RS03600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4E84_RS03605	COG1993	acr, cog1993
A4E84_RS03610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4E84_RS03635	COG1653	transport
A4E84_RS03640	COG1175	transmembrane transport
A4E84_RS03645	COG0395	ABC-type sugar transport system, permease component
A4E84_RS03685	COG1609	Transcriptional regulator
A4E84_RS03705	COG0667	Aldo Keto reductase
A4E84_RS03720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4E84_RS03735	COG3842	ATPase activity
A4E84_RS03770	COG0247	lactate metabolic process
A4E84_RS03770	COG0277	FAD linked oxidase domain protein
A4E84_RS03775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4E84_RS03800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4E84_RS03805	COG2151	metal-sulfur cluster biosynthetic enzyme
A4E84_RS03810	COG3396	Phenylacetate-CoA oxygenase
A4E84_RS03815	COG3460	Phenylacetate-CoA oxygenase
A4E84_RS03820	COG3396	Phenylacetate-CoA oxygenase
A4E84_RS03905	COG1024	Enoyl-CoA hydratase
A4E84_RS03905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4E84_RS03910	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4E84_RS03920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4E84_RS03925	COG0298	carbon dioxide binding
A4E84_RS03940	COG0375	protein maturation
A4E84_RS03985	COG0281	malic enzyme
A4E84_RS04020	COG3290	protein histidine kinase activity
A4E84_RS04055	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4E84_RS04065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4E84_RS04080	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4E84_RS04085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4E84_RS04090	COG1309	transcriptional regulator
A4E84_RS04120	COG2755	lipolytic protein G-D-S-L family
A4E84_RS04150	COG3250	beta-galactosidase activity
A4E84_RS04165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4E84_RS04180	COG1024	Enoyl-CoA hydratase
A4E84_RS04185	COG1024	Enoyl-CoA hydratase
A4E84_RS04190	COG3424	synthase
A4E84_RS04200	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A4E84_RS04205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4E84_RS04210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4E84_RS04215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4E84_RS04235	COG1131	(ABC) transporter
A4E84_RS04330	COG1132	(ABC) transporter
A4E84_RS04335	COG2197	response regulator
A4E84_RS04340	COG4585	Histidine kinase
A4E84_RS04360	COG1024	Enoyl-CoA hydratase
A4E84_RS04365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4E84_RS04390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4E84_RS04395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A4E84_RS04400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4E84_RS04405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4E84_RS04450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4E84_RS04460	COG0673	inositol 2-dehydrogenase activity
A4E84_RS04470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4E84_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS04515	COG1215	transferase activity, transferring glycosyl groups
A4E84_RS04530	COG3217	Mosc domain protein beta barrel domain protein
A4E84_RS04530	COG0633	Ferredoxin
A4E84_RS04550	COG1349	DNA-binding transcription factor activity
A4E84_RS04605	COG1940	carbohydrate kinase activity
A4E84_RS04615	COG2813	Specifically methylates the guanine in position
A4E84_RS04620	COG0191	fructose-bisphosphate aldolase activity
A4E84_RS04625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4E84_RS04630	COG1349	DNA-binding transcription factor activity
A4E84_RS04635	COG3387	PFAM Glycoside hydrolase 15-related
A4E84_RS04645	COG2608	mercury ion transmembrane transporter activity
A4E84_RS04655	COG4106	trans-aconitate 2-methyltransferase activity
A4E84_RS04670	COG0395	ABC-type sugar transport system, permease component
A4E84_RS04675	COG1175	transmembrane transport
A4E84_RS04695	COG0673	inositol 2-dehydrogenase activity
A4E84_RS04715	COG1231	oxidoreductase activity
A4E84_RS04740	COG1609	Transcriptional regulator
A4E84_RS04750	COG0395	ABC-type sugar transport system, permease component
A4E84_RS04755	COG4209	transmembrane transport
A4E84_RS04780	COG3594	Acyltransferase
A4E84_RS04790	COG1609	Transcriptional regulator
A4E84_RS04800	COG1175	transmembrane transport
A4E84_RS04840	COG0326	Molecular chaperone. Has ATPase activity
A4E84_RS04865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4E84_RS04890	COG2264	protein methyltransferase activity
A4E84_RS04915	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS04940	COG2197	response regulator
A4E84_RS04945	COG4585	Histidine kinase
A4E84_RS04970	COG4608	Belongs to the ABC transporter superfamily
A4E84_RS04980	COG0601	transmembrane transport
A4E84_RS04985	COG0747	negative chemotaxis
A4E84_RS04990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4E84_RS04995	COG1660	Displays ATPase and GTPase activities
A4E84_RS05010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4E84_RS05040	COG0515	serine threonine protein kinase
A4E84_RS05040	COG2815	serine threonine protein kinase
A4E84_RS05055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4E84_RS05080	COG0204	Acyl-transferase
A4E84_RS05110	COG0584	glycerophosphoryl diester phosphodiesterase
A4E84_RS05155	COG0671	phosphoesterase, PA-phosphatase related
A4E84_RS05160	COG1309	transcriptional regulator
A4E84_RS05200	COG0640	Transcriptional regulator
A4E84_RS05205	COG1902	pentaerythritol trinitrate reductase activity
A4E84_RS05210	COG3509	depolymerase
A4E84_RS05225	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS05245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4E84_RS05250	COG2971	BadF BadG BcrA BcrD
A4E84_RS05260	COG2706	6-phosphogluconolactonase activity
A4E84_RS05275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4E84_RS05305	COG1653	transport
A4E84_RS05310	COG1175	transmembrane transport
A4E84_RS05315	COG0395	ABC-type sugar transport system, permease component
A4E84_RS05320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4E84_RS05325	COG4948	Mandelate Racemase Muconate Lactonizing
A4E84_RS05345	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS05355	COG1082	Xylose isomerase domain protein TIM barrel
A4E84_RS05360	COG0673	inositol 2-dehydrogenase activity
A4E84_RS05375	COG1609	Transcriptional regulator
A4E84_RS05385	COG0596	Alpha beta hydrolase
A4E84_RS05410	COG2080	2 iron, 2 sulfur cluster binding
A4E84_RS05415	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4E84_RS05420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4E84_RS05425	COG3608	succinylglutamate desuccinylase aspartoacylase
A4E84_RS05425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4E84_RS05430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4E84_RS05460	COG3693	PFAM glycoside hydrolase, family 10
A4E84_RS05465	COG1408	metallophosphoesterase
A4E84_RS05525	COG4977	sequence-specific DNA binding
A4E84_RS05540	COG1522	sequence-specific DNA binding
A4E84_RS05625	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4E84_RS05635	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS05650	COG0432	Pfam Uncharacterised protein family UPF0047
A4E84_RS05660	COG2072	flavoprotein involved in K transport
A4E84_RS05670	COG1132	(ABC) transporter
A4E84_RS05690	COG1132	(ABC) transporter
A4E84_RS05695	COG1132	(ABC) transporter
A4E84_RS05705	COG0254	rRNA binding
A4E84_RS05720	COG1946	Acyl-CoA thioesterase
A4E84_RS05740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4E84_RS05755	COG2018	Roadblock/LC7 domain
A4E84_RS05815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4E84_RS05835	COG2115	Belongs to the xylose isomerase family
A4E84_RS05845	COG1846	Transcriptional regulator
A4E84_RS05845	COG1940	carbohydrate kinase activity
A4E84_RS05880	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS05885	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS05895	COG1396	sequence-specific DNA binding
A4E84_RS05895	COG3800	Transcriptional regulator
A4E84_RS05900	COG3634	alkyl hydroperoxide reductase activity
A4E84_RS05910	COG1793	dna ligase
A4E84_RS05920	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS05935	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS05945	COG0242	peptide deformylase activity
A4E84_RS05955	COG3442	glutamine amidotransferase
A4E84_RS05960	COG0205	6-phosphofructokinase activity
A4E84_RS05975	COG3275	phosphorelay sensor kinase activity
A4E84_RS05980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4E84_RS05990	COG3279	Response regulator of the LytR AlgR family
A4E84_RS05995	COG1522	sequence-specific DNA binding
A4E84_RS06000	COG1834	amidinotransferase
A4E84_RS06005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4E84_RS06020	COG0698	ribose 5-phosphate isomerase
A4E84_RS06040	COG0829	nickel cation binding
A4E84_RS06045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4E84_RS06055	COG0804	urea catabolic process
A4E84_RS06060	COG0832	Belongs to the urease beta subunit family
A4E84_RS06065	COG0831	urea catabolic process
A4E84_RS06070	COG1309	transcriptional regulator
A4E84_RS06085	COG0740	serine-type endopeptidase activity
A4E84_RS06125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4E84_RS06130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4E84_RS06135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4E84_RS06150	COG2226	methyltransferase
A4E84_RS06165	COG1136	(ABC) transporter
A4E84_RS06165	COG0577	efflux transmembrane transporter activity
A4E84_RS06195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4E84_RS06200	COG3663	DNA glycosylase
A4E84_RS06220	COG4585	Histidine kinase
A4E84_RS06225	COG2197	response regulator
A4E84_RS06235	COG2188	Transcriptional regulator
A4E84_RS06240	COG1595	DNA-templated transcription, initiation
A4E84_RS06255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4E84_RS06270	COG0626	cystathionine gamma-synthase activity
A4E84_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS06300	COG1522	sequence-specific DNA binding
A4E84_RS06305	COG0419	ATPase involved in DNA repair
A4E84_RS06310	COG0420	3'-5' exonuclease activity
A4E84_RS06315	COG1739	Uncharacterized protein family UPF0029
A4E84_RS06330	COG0215	cysteine-tRNA ligase activity
A4E84_RS06335	COG1120	ATPase activity
A4E84_RS06340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4E84_RS06350	COG1832	CoA-binding protein
A4E84_RS06355	COG0531	amino acid
A4E84_RS06365	COG0640	Transcriptional regulator
A4E84_RS06390	COG0110	maltose O-acetyltransferase activity
A4E84_RS06405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A4E84_RS06435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4E84_RS06445	COG0183	Belongs to the thiolase family
A4E84_RS06455	COG1968	undecaprenyl-diphosphatase activity
A4E84_RS06525	COG1733	regulation of RNA biosynthetic process
A4E84_RS06540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4E84_RS06560	COG2318	DinB family
A4E84_RS06575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4E84_RS06580	COG0747	negative chemotaxis
A4E84_RS06630	COG0697	spore germination
A4E84_RS06675	COG0384	phenazine biosynthesis protein PhzF
A4E84_RS06700	COG1609	Transcriptional regulator
A4E84_RS06710	COG0395	ABC-type sugar transport system, permease component
A4E84_RS06715	COG1175	transmembrane transport
A4E84_RS06745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4E84_RS06745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4E84_RS06755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4E84_RS06795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4E84_RS06830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4E84_RS06840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4E84_RS06865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4E84_RS06870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4E84_RS06890	COG2018	Roadblock/LC7 domain
A4E84_RS06930	COG2814	Major facilitator Superfamily
A4E84_RS06935	COG4336	lyase activity
A4E84_RS06940	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4E84_RS06945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4E84_RS06950	COG1984	allophanate hydrolase subunit 2
A4E84_RS06955	COG2755	lipolytic protein G-D-S-L family
A4E84_RS06960	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS06990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4E84_RS07005	COG2270	Major facilitator Superfamily
A4E84_RS07015	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4E84_RS07020	COG1216	Glycosyl transferase, family 2
A4E84_RS07040	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS07085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4E84_RS07090	COG0140	phosphoribosyl-ATP diphosphatase activity
A4E84_RS07095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4E84_RS07100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4E84_RS07100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4E84_RS07105	COG3201	nicotinamide mononucleotide transporter
A4E84_RS07120	COG1090	epimerase
A4E84_RS07125	COG1846	Transcriptional regulator
A4E84_RS07125	COG1940	carbohydrate kinase activity
A4E84_RS07130	COG2223	nitrite transmembrane transporter activity
A4E84_RS07135	COG2233	PERMEase
A4E84_RS07155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4E84_RS07175	COG0531	amino acid
A4E84_RS07195	COG2390	Transcriptional regulator
A4E84_RS07200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4E84_RS07205	COG2409	Drug exporters of the RND superfamily
A4E84_RS07215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4E84_RS07230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4E84_RS07240	COG1758	RNA polymerase activity
A4E84_RS07245	COG0194	GDP metabolic process
A4E84_RS07255	COG0284	orotidine-5'-phosphate decarboxylase activity
A4E84_RS07260	COG0167	dihydroorotate dehydrogenase activity
A4E84_RS07265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4E84_RS07270	COG0505	Belongs to the CarA family
A4E84_RS07280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4E84_RS07285	COG0540	Belongs to the ATCase OTCase family
A4E84_RS07290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4E84_RS07300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4E84_RS07305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4E84_RS07310	COG0006	proline dipeptidase activity
A4E84_RS07320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4E84_RS07325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4E84_RS07330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4E84_RS07340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4E84_RS07350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4E84_RS07355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4E84_RS07370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4E84_RS07385	COG1131	(ABC) transporter
A4E84_RS07395	COG4585	Histidine kinase
A4E84_RS07400	COG2197	response regulator
A4E84_RS07405	COG0124	histidyl-tRNA synthetase
A4E84_RS07415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4E84_RS07420	COG1196	nuclear chromosome segregation
A4E84_RS07425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4E84_RS07430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4E84_RS07435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4E84_RS07440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4E84_RS07450	COG2255	four-way junction helicase activity
A4E84_RS07455	COG0632	four-way junction helicase activity
A4E84_RS07460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4E84_RS07465	COG0217	transcriptional regulatory protein
A4E84_RS07470	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A4E84_RS07475	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A4E84_RS07485	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS07490	COG1560	Kdo2-lipid A biosynthetic process
A4E84_RS07495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4E84_RS07520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4E84_RS07535	COG2176	DNA-directed DNA polymerase activity
A4E84_RS07535	COG5002	protein histidine kinase activity
A4E84_RS07565	COG0019	diaminopimelate decarboxylase activity
A4E84_RS07585	COG0395	ABC-type sugar transport system, permease component
A4E84_RS07590	COG1175	transmembrane transport
A4E84_RS07640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4E84_RS07695	COG2816	NAD+ diphosphatase activity
A4E84_RS07705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4E84_RS07705	COG1648	precorrin-2 dehydrogenase activity
A4E84_RS07710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A4E84_RS07725	COG1464	Belongs to the NlpA lipoprotein family
A4E84_RS07730	COG2011	ABC-type metal ion transport system permease component
A4E84_RS07735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4E84_RS07770	COG0204	Acyl-transferase
A4E84_RS07770	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS07775	COG0477	Major facilitator Superfamily
A4E84_RS07790	COG0165	Argininosuccinate lyase
A4E84_RS07810	COG1017	nitric oxide dioxygenase activity
A4E84_RS07810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4E84_RS07825	COG1438	arginine binding
A4E84_RS07830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4E84_RS07835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4E84_RS07840	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4E84_RS07845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4E84_RS07860	COG0640	Transcriptional regulator
A4E84_RS07870	COG0798	PFAM Bile acid sodium symporter
A4E84_RS07885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4E84_RS07890	COG0492	ferredoxin-NADP+ reductase activity
A4E84_RS07920	COG0697	spore germination
A4E84_RS07930	COG1649	PFAM Uncharacterised BCR, COG1649
A4E84_RS07955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4E84_RS07955	COG0072	phenylalanine-tRNA ligase activity
A4E84_RS07960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4E84_RS07965	COG5002	protein histidine kinase activity
A4E84_RS07970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4E84_RS07975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4E84_RS07980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4E84_RS07985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4E84_RS08020	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS08025	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS08030	COG0174	glutamine synthetase
A4E84_RS08040	COG0531	amino acid
A4E84_RS08045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4E84_RS08070	COG4176	ABC-type proline glycine betaine transport system permease component
A4E84_RS08075	COG4175	Glycine betaine
A4E84_RS08075	COG0517	IMP dehydrogenase activity
A4E84_RS08080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4E84_RS08095	COG0564	pseudouridine synthase activity
A4E84_RS08135	COG0805	protein transport
A4E84_RS08140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4E84_RS08160	COG2378	regulation of single-species biofilm formation
A4E84_RS08175	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4E84_RS08185	COG1609	Transcriptional regulator
A4E84_RS08190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4E84_RS08195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4E84_RS08205	COG4122	O-methyltransferase activity
A4E84_RS08210	COG1222	aaa ATPase
A4E84_RS08230	COG1994	Peptidase M50
A4E84_RS08230	COG0517	IMP dehydrogenase activity
A4E84_RS08240	COG2197	response regulator
A4E84_RS08245	COG0747	negative chemotaxis
A4E84_RS08250	COG4166	transmembrane transport
A4E84_RS08255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4E84_RS08260	COG1410	methionine synthase
A4E84_RS08260	COG0646	methionine synthase
A4E84_RS08265	COG1414	Transcriptional regulator
A4E84_RS08270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4E84_RS08275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4E84_RS08280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4E84_RS08285	COG2186	Transcriptional regulator
A4E84_RS08295	COG0215	cysteine-tRNA ligase activity
A4E84_RS08310	COG0588	phosphoglycerate mutase activity
A4E84_RS08315	COG0598	Magnesium transport protein CorA
A4E84_RS08325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS08335	COG0667	Aldo Keto reductase
A4E84_RS08365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4E84_RS08375	COG3012	SEC-C Motif Domain Protein
A4E84_RS08380	COG2186	Transcriptional regulator
A4E84_RS08385	COG3265	gluconokinase activity
A4E84_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS08400	COG1063	alcohol dehydrogenase
A4E84_RS08430	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4E84_RS08435	COG2149	membrane
A4E84_RS08470	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS08480	COG3876	Protein conserved in bacteria
A4E84_RS08525	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS08535	COG0640	Transcriptional regulator
A4E84_RS08545	COG0477	Major facilitator Superfamily
A4E84_RS08580	COG2851	Citrate transporter
A4E84_RS08585	COG0243	molybdopterin cofactor binding
A4E84_RS08590	COG1309	transcriptional regulator
A4E84_RS08600	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A4E84_RS08605	COG2188	Transcriptional regulator
A4E84_RS08640	COG1595	DNA-templated transcription, initiation
A4E84_RS08660	COG2815	serine threonine protein kinase
A4E84_RS08660	COG0515	serine threonine protein kinase
A4E84_RS08665	COG2755	lipolytic protein G-D-S-L family
A4E84_RS08680	COG1216	Glycosyl transferase, family 2
A4E84_RS08685	COG0726	polysaccharide deacetylase
A4E84_RS08685	COG1649	PFAM Uncharacterised BCR, COG1649
A4E84_RS08705	COG1725	Transcriptional regulator
A4E84_RS08720	COG2226	methyltransferase
A4E84_RS08745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4E84_RS08745	COG0662	Cupin 2, conserved barrel domain protein
A4E84_RS08750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4E84_RS08755	COG0587	DNA-directed DNA polymerase activity
A4E84_RS08780	COG1799	cell septum assembly
A4E84_RS08785	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS08790	COG0477	Major facilitator Superfamily
A4E84_RS08800	COG0671	phosphoesterase, PA-phosphatase related
A4E84_RS08830	COG0411	ABC transporter
A4E84_RS08840	COG1652	LysM domain
A4E84_RS08855	COG1160	GTP binding
A4E84_RS08865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4E84_RS08890	COG0494	nUDIX hydrolase
A4E84_RS08895	COG1187	pseudouridine synthase activity
A4E84_RS08900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4E84_RS08905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4E84_RS08920	COG0686	Belongs to the AlaDH PNT family
A4E84_RS08930	COG0494	nUDIX hydrolase
A4E84_RS08935	COG0504	CTP synthase activity
A4E84_RS08940	COG3387	PFAM Glycoside hydrolase 15-related
A4E84_RS08960	COG0497	DNA recombination
A4E84_RS08965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4E84_RS08985	COG1120	ATPase activity
A4E84_RS08990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4E84_RS08995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4E84_RS09000	COG0647	UMP catabolic process
A4E84_RS09040	COG2094	Belongs to the DNA glycosylase MPG family
A4E84_RS09050	COG1881	PFAM PEBP family protein
A4E84_RS09070	COG1119	ATPase activity
A4E84_RS09085	COG2197	response regulator
A4E84_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS09100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4E84_RS09110	COG1131	(ABC) transporter
A4E84_RS09110	COG0842	Transport permease protein
A4E84_RS09110	COG1716	ATPase activity
A4E84_RS09120	COG3830	Belongs to the UPF0237 family
A4E84_RS09120	COG0560	Phosphoserine phosphatase
A4E84_RS09125	COG0588	phosphoglycerate mutase activity
A4E84_RS09135	COG2807	transmembrane transport
A4E84_RS09140	COG2186	Transcriptional regulator
A4E84_RS09170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4E84_RS09175	COG2261	transglycosylase associated protein
A4E84_RS09190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4E84_RS09195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4E84_RS09210	COG1404	Belongs to the peptidase S8 family
A4E84_RS09220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4E84_RS09235	COG3387	PFAM Glycoside hydrolase 15-related
A4E84_RS09285	COG0488	(ABC) transporter
A4E84_RS09305	COG0235	Class ii aldolase
A4E84_RS09325	COG1492	cobalamin metabolic process
A4E84_RS09345	COG1797	cobyrinic acid a,c-diamide synthase activity
A4E84_RS09375	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
A4E84_RS09395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4E84_RS09400	COG2318	DinB family
A4E84_RS09405	COG0456	acetyltransferase
A4E84_RS09410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4E84_RS09415	COG1917	Cupin 2, conserved barrel domain protein
A4E84_RS09420	COG5285	phytanoyl-CoA dioxygenase
A4E84_RS09430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4E84_RS09450	COG1414	Transcriptional regulator
A4E84_RS09465	COG4585	Histidine kinase
A4E84_RS09470	COG2197	response regulator
A4E84_RS09475	COG0768	penicillin binding
A4E84_RS09480	COG2252	PERMEase
A4E84_RS09485	COG1595	DNA-templated transcription, initiation
A4E84_RS09525	COG4677	pectinesterase activity
A4E84_RS09530	COG3866	Pectate lyase
A4E84_RS09535	COG2755	lipolytic protein G-D-S-L family
A4E84_RS09550	COG3507	Belongs to the glycosyl hydrolase 43 family
A4E84_RS09565	COG3866	Pectate lyase
A4E84_RS09570	COG0395	ABC-type sugar transport system, permease component
A4E84_RS09575	COG1175	transmembrane transport
A4E84_RS09590	COG1802	Transcriptional regulator
A4E84_RS09615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4E84_RS09620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4E84_RS09640	COG0395	ABC-type sugar transport system, permease component
A4E84_RS09645	COG1063	alcohol dehydrogenase
A4E84_RS09660	COG1309	transcriptional regulator
A4E84_RS09665	COG1609	Transcriptional regulator
A4E84_RS09710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4E84_RS09720	COG2171	N-acyltransferase activity
A4E84_RS09725	COG3226	Transcriptional regulator
A4E84_RS09730	COG2076	Multidrug Resistance protein
A4E84_RS09740	COG2151	metal-sulfur cluster biosynthetic enzyme
A4E84_RS09745	COG0822	iron-sulfur transferase activity
A4E84_RS09750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4E84_RS09755	COG0396	ATPase activity
A4E84_RS09765	COG0719	Fe-S assembly protein
A4E84_RS09780	COG2746	aminoglycoside 3-N-acetyltransferase activity
A4E84_RS09785	COG1131	(ABC) transporter
A4E84_RS09810	COG0109	protoheme IX farnesyltransferase activity
A4E84_RS09820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4E84_RS09835	COG0363	glucosamine-6-phosphate deaminase activity
A4E84_RS09840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4E84_RS09845	COG0395	ABC-type sugar transport system, permease component
A4E84_RS09850	COG1175	transmembrane transport
A4E84_RS09855	COG1653	transport
A4E84_RS09860	COG0366	Alpha amylase catalytic
A4E84_RS09870	COG1695	Transcriptional regulator
A4E84_RS09875	COG1136	(ABC) transporter
A4E84_RS09890	COG0166	Belongs to the GPI family
A4E84_RS09905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4E84_RS09910	COG0149	triose-phosphate isomerase activity
A4E84_RS09915	COG0126	phosphoglycerate kinase activity
A4E84_RS09920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4E84_RS09930	COG1481	regulation of sporulation
A4E84_RS09935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4E84_RS09940	COG1660	Displays ATPase and GTPase activities
A4E84_RS09945	COG0322	excinuclease ABC activity
A4E84_RS09955	COG1609	Transcriptional regulator
A4E84_RS09975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4E84_RS10020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4E84_RS10030	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4E84_RS10035	COG0477	Major facilitator Superfamily
A4E84_RS10040	COG0387	Pfam Sodium calcium exchanger
A4E84_RS10065	COG0556	nucleotide-excision repair
A4E84_RS10075	COG0584	glycerophosphoryl diester phosphodiesterase
A4E84_RS10080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4E84_RS10090	COG2313	pseudouridylate synthase activity
A4E84_RS10095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4E84_RS10095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4E84_RS10100	COG2226	methyltransferase
A4E84_RS10105	COG0598	Magnesium transport protein CorA
A4E84_RS10135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4E84_RS10140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4E84_RS10170	COG1132	(ABC) transporter
A4E84_RS10185	COG0402	S-adenosylhomocysteine deaminase activity
A4E84_RS10225	COG1953	Uracil, thiamine, allantoin
A4E84_RS10230	COG1802	Transcriptional regulator
A4E84_RS10285	COG0237	dephospho-CoA kinase activity
A4E84_RS10295	COG0539	negative regulation of cytoplasmic translation
A4E84_RS10305	COG1643	Atp-dependent helicase
A4E84_RS10340	COG2050	protein possibly involved in aromatic compounds catabolism
A4E84_RS10395	COG2968	Membrane
A4E84_RS10400	COG0737	Belongs to the 5'-nucleotidase family
A4E84_RS10420	COG0745	RESPONSE REGULATOR receiver
A4E84_RS10425	COG0287	Prephenate dehydrogenase
A4E84_RS10425	COG1605	Chorismate mutase
A4E84_RS10440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4E84_RS10445	COG2304	oxidoreductase activity
A4E84_RS10450	COG1136	(ABC) transporter
A4E84_RS10480	COG0067	glutamate synthase
A4E84_RS10480	COG0069	glutamate synthase activity
A4E84_RS10480	COG0070	glutamate synthase
A4E84_RS10510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4E84_RS10520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4E84_RS10530	COG0159	tryptophan synthase activity
A4E84_RS10535	COG0133	tryptophan synthase activity
A4E84_RS10540	COG0134	indole-3-glycerol-phosphate synthase activity
A4E84_RS10560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4E84_RS10565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4E84_RS10575	COG0107	imidazoleglycerol-phosphate synthase activity
A4E84_RS10580	COG0251	oxidation-reduction process
A4E84_RS10585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4E84_RS10590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4E84_RS10595	COG0131	Imidazoleglycerol-phosphate dehydratase
A4E84_RS10600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4E84_RS10605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4E84_RS10630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4E84_RS10650	COG1432	Conserved Protein
A4E84_RS10655	COG0587	DNA-directed DNA polymerase activity
A4E84_RS10710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4E84_RS10720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4E84_RS10725	COG3599	regulation of cell shape
A4E84_RS10735	COG1799	cell septum assembly
A4E84_RS10745	COG1496	oxidoreductase activity
A4E84_RS10750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4E84_RS10755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4E84_RS10760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4E84_RS10770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4E84_RS10775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4E84_RS10785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4E84_RS10800	COG0275	rRNA processing
A4E84_RS10810	COG0714	Associated with various cellular activities
A4E84_RS10830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4E84_RS10840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A4E84_RS10850	COG1309	transcriptional regulator
A4E84_RS10870	COG0352	thiamine-phosphate diphosphorylase activity
A4E84_RS10880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4E84_RS10890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4E84_RS10890	COG2022	thiamine diphosphate biosynthetic process
A4E84_RS10900	COG2022	thiamine diphosphate biosynthetic process
A4E84_RS10905	COG0515	serine threonine protein kinase
A4E84_RS10905	COG2815	serine threonine protein kinase
A4E84_RS10910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4E84_RS10915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4E84_RS10920	COG2193	ferroxidase activity
A4E84_RS10925	COG0243	molybdopterin cofactor binding
A4E84_RS10930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A4E84_RS10940	COG0205	6-phosphofructokinase activity
A4E84_RS10945	COG2197	response regulator
A4E84_RS10950	COG4585	Histidine kinase
A4E84_RS10975	COG1940	carbohydrate kinase activity
A4E84_RS10985	COG0003	Pfam Anion-transporting ATPase
A4E84_RS11000	COG1022	Amp-dependent synthetase and ligase
A4E84_RS11020	COG0534	Mate efflux family protein
A4E84_RS11070	COG2205	protein histidine kinase activity
A4E84_RS11075	COG0745	RESPONSE REGULATOR receiver
A4E84_RS11085	COG1929	Belongs to the glycerate kinase type-1 family
A4E84_RS11090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4E84_RS11095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4E84_RS11100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4E84_RS11105	COG0723	plastoquinol--plastocyanin reductase activity
A4E84_RS11110	COG2010	Cytochrome c
A4E84_RS11115	COG1845	cytochrome c oxidase, subunit III
A4E84_RS11125	COG1376	ErfK ybiS ycfS ynhG family protein
A4E84_RS11135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4E84_RS11140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4E84_RS11150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4E84_RS11170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4E84_RS11175	COG0515	serine threonine protein kinase
A4E84_RS11175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4E84_RS11180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4E84_RS11185	COG2197	response regulator
A4E84_RS11210	COG2226	methyltransferase
A4E84_RS11230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A4E84_RS11245	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A4E84_RS11280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4E84_RS11285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4E84_RS11290	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4E84_RS11300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4E84_RS11305	COG0733	neurotransmitter:sodium symporter activity
A4E84_RS11340	COG1090	epimerase
A4E84_RS11355	COG0321	lipoyl(octanoyl) transferase activity
A4E84_RS11360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4E84_RS11415	COG0501	Belongs to the peptidase M48B family
A4E84_RS11455	COG0745	RESPONSE REGULATOR receiver
A4E84_RS11470	COG2197	response regulator
A4E84_RS11495	COG1309	transcriptional regulator
A4E84_RS11520	COG0366	Alpha amylase catalytic
A4E84_RS11525	COG3833	ABC-type maltose transport systems, permease component
A4E84_RS11530	COG1175	transmembrane transport
A4E84_RS11540	COG1609	Transcriptional regulator
A4E84_RS11550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4E84_RS11585	COG0174	glutamine synthetase
A4E84_RS11595	COG1959	2 iron, 2 sulfur cluster binding
A4E84_RS11615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4E84_RS11615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4E84_RS11620	COG0640	Transcriptional regulator
A4E84_RS11625	COG0346	lactoylglutathione lyase activity
A4E84_RS11635	COG2814	Major facilitator Superfamily
A4E84_RS11650	COG0477	Major facilitator Superfamily
A4E84_RS11655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4E84_RS11675	COG1994	Peptidase M50
A4E84_RS11710	COG5398	heme oxygenase
A4E84_RS11730	COG2837	iron assimilation
A4E84_RS11735	COG0672	)-iron permease
A4E84_RS11750	COG0584	glycerophosphoryl diester phosphodiesterase
A4E84_RS11780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4E84_RS11785	COG2814	Major facilitator Superfamily
A4E84_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS11800	COG0667	Aldo Keto reductase
A4E84_RS11810	COG2259	Doxx family
A4E84_RS11885	COG1201	RNA secondary structure unwinding
A4E84_RS11920	COG3022	response to hydroperoxide
A4E84_RS11925	COG0800	Aldolase
A4E84_RS11940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4E84_RS11950	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS11955	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A4E84_RS11960	COG2030	dehydratase
A4E84_RS11965	COG0500	methyltransferase
A4E84_RS11975	COG0477	Major facilitator Superfamily
A4E84_RS11990	COG2247	cell wall binding repeat
A4E84_RS11990	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4E84_RS12000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS12035	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS12040	COG1309	transcriptional regulator
A4E84_RS12080	COG1657	PFAM Prenyltransferase squalene oxidase
A4E84_RS12095	COG3845	ABC transporter
A4E84_RS12105	COG0137	argininosuccinate synthase activity
A4E84_RS12135	COG2124	cytochrome p450
A4E84_RS12140	COG0183	Belongs to the thiolase family
A4E84_RS12175	COG4122	O-methyltransferase activity
A4E84_RS12215	COG3896	Chloramphenicol phosphotransferase-like protein
A4E84_RS12245	COG2259	Doxx family
A4E84_RS12265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4E84_RS12320	COG0586	Pfam SNARE associated Golgi protein
A4E84_RS12330	COG1358	cellular component organization or biogenesis
A4E84_RS12375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4E84_RS12380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4E84_RS12390	COG0477	Major facilitator Superfamily
A4E84_RS12395	COG1309	transcriptional regulator
A4E84_RS12410	COG0667	Aldo Keto reductase
A4E84_RS12415	COG0789	Transcriptional regulator
A4E84_RS12430	COG1741	Belongs to the pirin family
A4E84_RS12445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4E84_RS12450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4E84_RS12455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4E84_RS12505	COG1764	response to oxidative stress
A4E84_RS12510	COG2130	NADP-dependent
A4E84_RS12545	COG1129	ABC transporter
A4E84_RS12550	COG4214	carbohydrate transport
A4E84_RS12560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4E84_RS12565	COG3940	Belongs to the glycosyl hydrolase 43 family
A4E84_RS12570	COG3507	Belongs to the glycosyl hydrolase 43 family
A4E84_RS12580	COG3467	pyridoxamine 5'-phosphate
A4E84_RS12615	COG0395	ABC-type sugar transport system, permease component
A4E84_RS12620	COG1175	transmembrane transport
A4E84_RS12645	COG3386	PFAM SMP-30 Gluconolaconase
A4E84_RS12650	COG1414	Transcriptional regulator
A4E84_RS12685	COG4981	capsule polysaccharide biosynthetic process
A4E84_RS12720	COG0477	Major facilitator Superfamily
A4E84_RS12750	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS12755	COG0825	malonyl-CoA metabolic process
A4E84_RS12755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4E84_RS12770	COG2255	four-way junction helicase activity
A4E84_RS12780	COG1077	Cell shape determining protein MreB Mrl
A4E84_RS12850	COG2409	Drug exporters of the RND superfamily
A4E84_RS12855	COG2205	protein histidine kinase activity
A4E84_RS12860	COG0745	RESPONSE REGULATOR receiver
A4E84_RS12885	COG1070	Carbohydrate kinase
A4E84_RS12900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4E84_RS12915	COG0358	DNA primase activity
A4E84_RS12925	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4E84_RS12960	COG0243	molybdopterin cofactor binding
A4E84_RS12975	COG0431	NADPH-dependent FMN reductase
A4E84_RS12990	COG1733	regulation of RNA biosynthetic process
A4E84_RS12995	COG2084	Dehydrogenase
A4E84_RS13005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4E84_RS13010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4E84_RS13010	COG2146	nitrite reductase [NAD(P)H] activity
A4E84_RS13030	COG0659	secondary active sulfate transmembrane transporter activity
A4E84_RS13040	COG0745	RESPONSE REGULATOR receiver
A4E84_RS13045	COG0642	Histidine kinase
A4E84_RS13060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4E84_RS13060	COG0574	Belongs to the PEP-utilizing enzyme family
A4E84_RS13065	COG1940	carbohydrate kinase activity
A4E84_RS13065	COG1846	Transcriptional regulator
A4E84_RS13070	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A4E84_RS13115	COG0667	Aldo Keto reductase
A4E84_RS13120	COG1280	lysine exporter protein (LysE YggA)
A4E84_RS13130	COG0423	glycine-tRNA ligase activity
A4E84_RS13135	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4E84_RS13135	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4E84_RS13140	COG1121	(ABC) transporter
A4E84_RS13145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4E84_RS13160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4E84_RS13165	COG1381	Involved in DNA repair and RecF pathway recombination
A4E84_RS13195	COG0747	negative chemotaxis
A4E84_RS13205	COG0444	Belongs to the ABC transporter superfamily
A4E84_RS13210	COG4608	Belongs to the ABC transporter superfamily
A4E84_RS13215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4E84_RS13220	COG2197	response regulator
A4E84_RS13225	COG4585	Histidine kinase
A4E84_RS13230	COG2409	Drug exporters of the RND superfamily
A4E84_RS13240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4E84_RS13255	COG2723	6-phospho-beta-galactosidase activity
A4E84_RS13265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4E84_RS13290	COG2315	Protein conserved in bacteria
A4E84_RS13300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4E84_RS13315	COG4948	Mandelate Racemase Muconate Lactonizing
A4E84_RS13320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4E84_RS13325	COG1414	Transcriptional regulator
A4E84_RS13335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4E84_RS13340	COG1234	tRNA 3'-trailer cleavage
A4E84_RS13345	COG0537	adenosine 5'-monophosphoramidase activity
A4E84_RS13350	COG0793	Belongs to the peptidase S41A family
A4E84_RS13350	COG4946	Tricorn protease homolog
A4E84_RS13370	COG2070	2-Nitropropane dioxygenase
A4E84_RS13375	COG0484	heat shock protein binding
A4E84_RS13380	COG1420	regulation of RNA biosynthetic process
A4E84_RS13420	COG0481	GTPase activity
A4E84_RS13425	COG0268	Binds directly to 16S ribosomal RNA
A4E84_RS13450	COG2353	YceI-like domain
A4E84_RS13455	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4E84_RS13460	COG1234	tRNA 3'-trailer cleavage
A4E84_RS13465	COG1555	photosystem II stabilization
A4E84_RS13470	COG1307	EDD domain protein, DegV family
A4E84_RS13480	COG0495	leucyl-tRNA aminoacylation
A4E84_RS13490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4E84_RS13510	COG0588	phosphoglycerate mutase activity
A4E84_RS13515	COG0799	negative regulation of ribosome biogenesis
A4E84_RS13525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4E84_RS13530	COG0501	Belongs to the peptidase M48B family
A4E84_RS13545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4E84_RS13555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4E84_RS13565	COG1215	transferase activity, transferring glycosyl groups
A4E84_RS13580	COG3540	Alkaline phosphatase
A4E84_RS13590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4E84_RS13595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4E84_RS13600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4E84_RS13605	COG1530	ribonuclease E activity
A4E84_RS13625	COG3655	Transcriptional regulator
A4E84_RS13655	COG0772	Belongs to the SEDS family
A4E84_RS13675	COG1077	Cell shape determining protein MreB Mrl
A4E84_RS13680	COG0105	UTP biosynthetic process
A4E84_RS13690	COG0285	dihydrofolate synthase activity
A4E84_RS13695	COG0525	valine-tRNA ligase activity
A4E84_RS13705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4E84_RS13710	COG0740	serine-type endopeptidase activity
A4E84_RS13715	COG0740	serine-type endopeptidase activity
A4E84_RS13720	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4E84_RS13745	COG3594	Acyltransferase
A4E84_RS13770	COG4552	Acetyltransferase involved in intracellular survival and related
A4E84_RS13785	COG1113	amino acid transport
A4E84_RS13790	COG0515	serine threonine protein kinase
A4E84_RS13815	COG1113	amino acid transport
A4E84_RS13830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4E84_RS13840	COG0406	alpha-ribazole phosphatase activity
A4E84_RS13845	COG1070	Carbohydrate kinase
A4E84_RS13850	COG1653	transport
A4E84_RS13855	COG1175	transmembrane transport
A4E84_RS13860	COG0395	ABC-type sugar transport system, permease component
A4E84_RS13865	COG3842	ATPase activity
A4E84_RS13870	COG1349	DNA-binding transcription factor activity
A4E84_RS13890	COG0584	glycerophosphoryl diester phosphodiesterase
A4E84_RS13900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4E84_RS13960	COG1846	Transcriptional regulator
A4E84_RS14000	COG1136	(ABC) transporter
A4E84_RS14015	COG0668	transmembrane transport
A4E84_RS14020	COG1940	carbohydrate kinase activity
A4E84_RS14030	COG1175	transmembrane transport
A4E84_RS14035	COG0395	ABC-type sugar transport system, permease component
A4E84_RS14040	COG1486	melibiose metabolic process
A4E84_RS14055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4E84_RS14085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4E84_RS14090	COG2346	COG2346, Truncated hemoglobins
A4E84_RS14110	COG4977	sequence-specific DNA binding
A4E84_RS14125	COG0629	single-stranded DNA binding
A4E84_RS14170	COG2267	carboxylic ester hydrolase activity
A4E84_RS14185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4E84_RS14230	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS14235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4E84_RS14255	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS14390	COG3962	Belongs to the TPP enzyme family
A4E84_RS14400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4E84_RS14430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4E84_RS14435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4E84_RS14440	COG1869	D-ribose catabolic process
A4E84_RS14445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4E84_RS14455	COG1129	ABC transporter
A4E84_RS14460	COG1609	Transcriptional regulator
A4E84_RS14475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4E84_RS14500	COG0789	Transcriptional regulator
A4E84_RS14515	COG1846	Transcriptional regulator
A4E84_RS14515	COG0456	acetyltransferase
A4E84_RS14530	COG0673	inositol 2-dehydrogenase activity
A4E84_RS14555	COG1472	Belongs to the glycosyl hydrolase 3 family
A4E84_RS14600	COG0028	Belongs to the TPP enzyme family
A4E84_RS14620	COG1946	Acyl-CoA thioesterase
A4E84_RS14630	COG1309	transcriptional regulator
A4E84_RS14635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4E84_RS14650	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS14670	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A4E84_RS14700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4E84_RS14710	COG0589	response to stress
A4E84_RS14720	COG4977	sequence-specific DNA binding
A4E84_RS14725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4E84_RS14740	COG0494	nUDIX hydrolase
A4E84_RS14755	COG1653	transport
A4E84_RS14765	COG0395	ABC-type sugar transport system, permease component
A4E84_RS14775	COG3345	alpha-galactosidase
A4E84_RS14780	COG0395	ABC-type sugar transport system, permease component
A4E84_RS14785	COG1175	transmembrane transport
A4E84_RS14800	COG0745	RESPONSE REGULATOR receiver
A4E84_RS14825	COG0406	alpha-ribazole phosphatase activity
A4E84_RS14875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS14905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4E84_RS14910	COG0154	amidase activity
A4E84_RS14920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4E84_RS14925	COG0765	amino acid transport
A4E84_RS14930	COG0765	amino acid transport
A4E84_RS14935	COG1126	abc transporter atp-binding protein
A4E84_RS14955	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS14965	COG3397	chitin binding
A4E84_RS14985	COG2186	Transcriptional regulator
A4E84_RS15030	COG3226	Transcriptional regulator
A4E84_RS15040	COG0673	inositol 2-dehydrogenase activity
A4E84_RS15045	COG4702	Belongs to the UPF0303 family
A4E84_RS15070	COG0515	serine threonine protein kinase
A4E84_RS15080	COG0706	membrane insertase activity
A4E84_RS15105	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4E84_RS15160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4E84_RS15210	COG2733	membrane
A4E84_RS15225	COG4555	ABC transporter
A4E84_RS15240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4E84_RS15245	COG2076	Multidrug Resistance protein
A4E84_RS15270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4E84_RS15280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4E84_RS15285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4E84_RS15290	COG1263	PTS System
A4E84_RS15295	COG1263	PTS System
A4E84_RS15300	COG1234	tRNA 3'-trailer cleavage
A4E84_RS15325	COG1113	amino acid transport
A4E84_RS15335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A4E84_RS15345	COG1335	isochorismatase
A4E84_RS15380	COG0277	FAD linked oxidase domain protein
A4E84_RS15385	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A4E84_RS15395	COG1174	glycine betaine transport
A4E84_RS15405	COG1174	glycine betaine transport
A4E84_RS15410	COG1732	Glycine betaine
A4E84_RS15430	COG1061	Type III restriction enzyme res subunit
A4E84_RS15440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4E84_RS15445	COG2226	methyltransferase
A4E84_RS15445	COG1073	alpha beta
A4E84_RS15450	COG0789	Transcriptional regulator
A4E84_RS15480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4E84_RS15485	COG0395	ABC-type sugar transport system, permease component
A4E84_RS15490	COG1175	transmembrane transport
A4E84_RS15505	COG1678	Uncharacterized ACR, COG1678
A4E84_RS15510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4E84_RS15515	COG0776	regulation of translation
A4E84_RS15525	COG3973	AAA domain
A4E84_RS15550	COG2223	nitrite transmembrane transporter activity
A4E84_RS15580	COG0583	DNA-binding transcription factor activity
A4E84_RS15600	COG1501	Belongs to the glycosyl hydrolase 31 family
A4E84_RS15605	COG1609	Transcriptional regulator
A4E84_RS15615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4E84_RS15620	COG0793	Belongs to the peptidase S41A family
A4E84_RS15630	COG2884	Cell division ATP-binding protein ftsE
A4E84_RS15645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4E84_RS15650	COG0515	serine threonine protein kinase
A4E84_RS15655	COG0515	serine threonine protein kinase
A4E84_RS15670	COG1175	transmembrane transport
A4E84_RS15675	COG0395	ABC-type sugar transport system, permease component
A4E84_RS15680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4E84_RS15685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4E84_RS15690	COG1216	Glycosyl transferase, family 2
A4E84_RS15695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4E84_RS15705	COG1764	response to oxidative stress
A4E84_RS15710	COG1846	Transcriptional regulator
A4E84_RS15740	COG1134	teichoic acid transport
A4E84_RS15745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4E84_RS15750	COG1216	Glycosyl transferase, family 2
A4E84_RS15760	COG2902	Dehydrogenase
A4E84_RS15780	COG0653	protein targeting
A4E84_RS15790	COG3214	Protein conserved in bacteria
A4E84_RS15795	COG2197	response regulator
A4E84_RS15800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4E84_RS15810	COG0823	Involved in the tonB-independent uptake of proteins
A4E84_RS15815	COG5002	protein histidine kinase activity
A4E84_RS15815	COG5000	phosphorelay sensor kinase activity
A4E84_RS15820	COG0745	RESPONSE REGULATOR receiver
A4E84_RS15825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4E84_RS15845	COG0714	Associated with various cellular activities
A4E84_RS15890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4E84_RS15900	COG1482	cell wall glycoprotein biosynthetic process
A4E84_RS15910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4E84_RS15950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4E84_RS15955	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A4E84_RS15955	COG0778	Nitroreductase
A4E84_RS15980	COG1316	TRANSCRIPTIONal
A4E84_RS15985	COG1316	TRANSCRIPTIONal
A4E84_RS15990	COG1316	TRANSCRIPTIONal
A4E84_RS15995	COG1316	TRANSCRIPTIONal
A4E84_RS16005	COG1316	TRANSCRIPTIONal
A4E84_RS16010	COG1607	acyl-coa hydrolase
A4E84_RS16015	COG1316	TRANSCRIPTIONal
A4E84_RS16025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4E84_RS16035	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4E84_RS16060	COG0789	Transcriptional regulator
A4E84_RS16065	COG1902	pentaerythritol trinitrate reductase activity
A4E84_RS16075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4E84_RS16090	COG2205	protein histidine kinase activity
A4E84_RS16095	COG0745	RESPONSE REGULATOR receiver
A4E84_RS16100	COG3104	oligopeptide transport
A4E84_RS16120	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS16125	COG1191	sigma factor activity
A4E84_RS16135	COG1228	amidohydrolase
A4E84_RS16150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4E84_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS16195	COG2755	lipolytic protein G-D-S-L family
A4E84_RS16200	COG0183	Belongs to the thiolase family
A4E84_RS16235	COG1136	(ABC) transporter
A4E84_RS16240	COG0577	efflux transmembrane transporter activity
A4E84_RS16245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4E84_RS16250	COG1252	NADH dehydrogenase
A4E84_RS16270	COG0148	phosphopyruvate hydratase activity
A4E84_RS16335	COG0577	efflux transmembrane transporter activity
A4E84_RS16340	COG1136	(ABC) transporter
A4E84_RS16345	COG0477	Major facilitator Superfamily
A4E84_RS16370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4E84_RS16405	COG4585	Histidine kinase
A4E84_RS16420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4E84_RS16425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4E84_RS16430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4E84_RS16435	COG0193	aminoacyl-tRNA hydrolase activity
A4E84_RS16450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4E84_RS16460	COG1309	transcriptional regulator
A4E84_RS16465	COG4106	trans-aconitate 2-methyltransferase activity
A4E84_RS16475	COG2197	response regulator
A4E84_RS16495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4E84_RS16535	COG0488	(ABC) transporter
A4E84_RS16545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4E84_RS16550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4E84_RS16555	COG3583	domain protein
A4E84_RS16555	COG3584	3D domain protein
A4E84_RS16560	COG0084	hydrolase, TatD family'
A4E84_RS16595	COG0310	cobalt ion transport
A4E84_RS16605	COG1122	ATPase activity
A4E84_RS16610	COG1846	Transcriptional regulator
A4E84_RS16615	COG1764	response to oxidative stress
A4E84_RS16635	COG0442	prolyl-tRNA aminoacylation
A4E84_RS16665	COG2409	Drug exporters of the RND superfamily
A4E84_RS16675	COG0793	Belongs to the peptidase S41A family
A4E84_RS16675	COG4946	Tricorn protease homolog
A4E84_RS16690	COG2267	carboxylic ester hydrolase activity
A4E84_RS16695	COG2072	flavoprotein involved in K transport
A4E84_RS16730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4E84_RS16735	COG0315	cyclic pyranopterin monophosphate synthase activity
A4E84_RS16735	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4E84_RS16740	COG0315	cyclic pyranopterin monophosphate synthase activity
A4E84_RS16750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4E84_RS16755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4E84_RS16775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4E84_RS16785	COG1970	mechanosensitive ion channel activity
A4E84_RS16800	COG3191	aminopeptidase activity
A4E84_RS16805	COG1376	ErfK ybiS ycfS ynhG family protein
A4E84_RS16815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4E84_RS16815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4E84_RS16815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4E84_RS16825	COG1349	DNA-binding transcription factor activity
A4E84_RS16830	COG0477	Major facilitator Superfamily
A4E84_RS16850	COG1247	-acetyltransferase
A4E84_RS16855	COG3384	dioxygenase
A4E84_RS16860	COG1846	Transcriptional regulator
A4E84_RS16880	COG1414	Transcriptional regulator
A4E84_RS16890	COG2319	Wd-40 repeat
A4E84_RS16890	COG4249	Peptidase C14 caspase catalytic subunit p20
A4E84_RS16905	COG0582	viral genome integration into host DNA
A4E84_RS16955	COG2188	Transcriptional regulator
A4E84_RS16990	COG3940	Belongs to the glycosyl hydrolase 43 family
A4E84_RS16995	COG3940	Belongs to the glycosyl hydrolase 43 family
A4E84_RS17050	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS17055	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS17065	COG1879	ABC-type sugar transport system periplasmic component
A4E84_RS17110	COG2197	response regulator
A4E84_RS17130	COG2132	Multicopper oxidase
A4E84_RS17220	COG0386	Belongs to the glutathione peroxidase family
A4E84_RS17245	COG1686	Belongs to the peptidase S11 family
A4E84_RS17315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4E84_RS17335	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS17340	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A4E84_RS17365	COG3903	Transcriptional regulator
A4E84_RS17365	COG3629	intracellular signal transduction
A4E84_RS17380	COG2706	6-phosphogluconolactonase activity
A4E84_RS17400	COG1024	Enoyl-CoA hydratase
A4E84_RS17405	COG2267	carboxylic ester hydrolase activity
A4E84_RS17410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4E84_RS17410	COG0515	serine threonine protein kinase
A4E84_RS17420	COG1309	transcriptional regulator
A4E84_RS17430	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS17475	COG0259	pyridoxamine-phosphate oxidase activity
A4E84_RS17490	COG1024	Enoyl-CoA hydratase
A4E84_RS17505	COG2814	Major facilitator Superfamily
A4E84_RS17515	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A4E84_RS17520	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS17540	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS17545	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS17565	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS17570	COG1595	DNA-templated transcription, initiation
A4E84_RS17620	COG0596	Alpha beta hydrolase
A4E84_RS17620	COG2945	thiolester hydrolase activity
A4E84_RS17630	COG4821	SIS domain
A4E84_RS17650	COG0259	pyridoxamine-phosphate oxidase activity
A4E84_RS17675	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS17690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4E84_RS17710	COG2318	DinB family
A4E84_RS17725	COG0277	FAD linked oxidase domain protein
A4E84_RS17725	COG0247	lactate metabolic process
A4E84_RS17730	COG0395	ABC-type sugar transport system, permease component
A4E84_RS17735	COG1175	transmembrane transport
A4E84_RS17745	COG1609	Transcriptional regulator
A4E84_RS17755	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4E84_RS17770	COG1136	(ABC) transporter
A4E84_RS17780	COG0596	Alpha beta hydrolase
A4E84_RS17785	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A4E84_RS17815	COG0667	Aldo Keto reductase
A4E84_RS17850	COG2252	PERMEase
A4E84_RS17865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4E84_RS17885	COG2814	Major facilitator Superfamily
A4E84_RS17895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4E84_RS17900	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A4E84_RS17905	COG1278	Cold shock
A4E84_RS17940	COG1061	Type III restriction enzyme res subunit
A4E84_RS17950	COG3973	AAA domain
A4E84_RS17955	COG3142	Participates in the control of copper homeostasis
A4E84_RS17985	COG1737	Transcriptional regulator
A4E84_RS17990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4E84_RS18035	COG0459	protein refolding
A4E84_RS18040	COG1278	Cold shock
A4E84_RS18055	COG0463	Glycosyl transferase, family 2
A4E84_RS18060	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A4E84_RS18105	COG3300	MHYT domain
A4E84_RS18105	COG5001	Diguanylate cyclase
A4E84_RS18120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4E84_RS18190	COG3842	ATPase activity
A4E84_RS18210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4E84_RS18215	COG0215	cysteine-tRNA ligase activity
A4E84_RS18220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4E84_RS18225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4E84_RS18230	COG1329	Transcriptional regulator
A4E84_RS18245	COG5002	protein histidine kinase activity
A4E84_RS18260	COG4941	Belongs to the sigma-70 factor family
A4E84_RS18265	COG3795	YCII-related domain
A4E84_RS18270	COG2318	DinB family
A4E84_RS18320	COG0588	phosphoglycerate mutase activity
A4E84_RS18355	COG2207	Transcriptional regulator
A4E84_RS18365	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS18405	COG1309	transcriptional regulator
A4E84_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS18420	COG3321	synthase
A4E84_RS18420	COG0604	alcohol dehydrogenase
A4E84_RS18450	COG2226	methyltransferase
A4E84_RS18500	COG0546	phosphoglycolate phosphatase activity
A4E84_RS18505	COG2188	Transcriptional regulator
A4E84_RS18525	COG2188	Transcriptional regulator
A4E84_RS18535	COG2186	Transcriptional regulator
A4E84_RS18540	COG4552	Acetyltransferase involved in intracellular survival and related
A4E84_RS18550	COG1490	D-aminoacyl-tRNA deacylase activity
A4E84_RS18565	COG3485	protocatechuate 3,4-dioxygenase
A4E84_RS18590	COG2897	thiosulfate sulfurtransferase activity
A4E84_RS18615	COG0745	RESPONSE REGULATOR receiver
A4E84_RS18620	COG1609	Transcriptional regulator
A4E84_RS18625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4E84_RS18675	COG0737	Belongs to the 5'-nucleotidase family
A4E84_RS18680	COG0456	acetyltransferase
A4E84_RS18705	COG1131	(ABC) transporter
A4E84_RS18720	COG1725	Transcriptional regulator
A4E84_RS18740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4E84_RS18770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4E84_RS18775	COG0306	phosphate transporter
A4E84_RS18785	COG1937	Protein conserved in bacteria
A4E84_RS18795	COG0277	FAD linked oxidase domain protein
A4E84_RS18800	COG0671	phosphoesterase, PA-phosphatase related
A4E84_RS18805	COG0739	heme binding
A4E84_RS18805	COG1196	nuclear chromosome segregation
A4E84_RS18805	COG0741	lytic transglycosylase activity
A4E84_RS18865	COG1131	(ABC) transporter
A4E84_RS18875	COG4585	Histidine kinase
A4E84_RS18880	COG2197	response regulator
A4E84_RS18920	COG1252	NADH dehydrogenase
A4E84_RS18950	COG0579	oxidoreductase
A4E84_RS18955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4E84_RS18965	COG0667	Aldo Keto reductase
A4E84_RS18980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4E84_RS18980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4E84_RS18990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4E84_RS19005	COG2172	sigma factor antagonist activity
A4E84_RS19010	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS19015	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS19030	COG1191	sigma factor activity
A4E84_RS19070	COG0513	Belongs to the DEAD box helicase family
A4E84_RS19105	COG1643	Atp-dependent helicase
A4E84_RS19130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4E84_RS19140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4E84_RS19170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4E84_RS19175	COG0047	phosphoribosylformylglycinamidine synthase activity
A4E84_RS19180	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4E84_RS19215	COG2197	response regulator
A4E84_RS19225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4E84_RS19240	COG0151	Belongs to the GarS family
A4E84_RS19330	COG2375	cellular response to nickel ion
A4E84_RS19330	COG1132	(ABC) transporter
A4E84_RS19360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4E84_RS19390	COG1191	sigma factor activity
A4E84_RS19395	COG1191	sigma factor activity
A4E84_RS19415	COG2353	YceI-like domain
A4E84_RS19435	COG3467	pyridoxamine 5'-phosphate
A4E84_RS19445	COG0477	Major facilitator Superfamily
A4E84_RS19450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4E84_RS19460	COG2205	protein histidine kinase activity
A4E84_RS19465	COG0745	RESPONSE REGULATOR receiver
A4E84_RS19480	COG1846	Transcriptional regulator
A4E84_RS19495	COG0789	Transcriptional regulator
A4E84_RS19520	COG0784	Response regulator, receiver
A4E84_RS19525	COG1309	transcriptional regulator
A4E84_RS19530	COG2814	Major facilitator Superfamily
A4E84_RS19535	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS19540	COG1595	DNA-templated transcription, initiation
A4E84_RS19585	COG2319	Wd-40 repeat
A4E84_RS19585	COG4249	Peptidase C14 caspase catalytic subunit p20
A4E84_RS19630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4E84_RS19665	COG0006	proline dipeptidase activity
A4E84_RS19690	COG1999	signal sequence binding
A4E84_RS19705	COG2837	iron assimilation
A4E84_RS19715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4E84_RS19720	COG0561	phosphatase activity
A4E84_RS19750	COG1131	(ABC) transporter
A4E84_RS19760	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A4E84_RS19765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS19770	COG0561	phosphatase activity
A4E84_RS19775	COG1196	nuclear chromosome segregation
A4E84_RS19775	COG0741	lytic transglycosylase activity
A4E84_RS19775	COG0739	heme binding
A4E84_RS19780	COG4988	ABC transporter
A4E84_RS19785	COG1294	oxidase, subunit
A4E84_RS19790	COG1271	oxidase subunit
A4E84_RS19800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4E84_RS19805	COG1609	Transcriptional regulator
A4E84_RS19820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4E84_RS19850	COG0662	Cupin 2, conserved barrel domain protein
A4E84_RS19855	COG1950	PFAM Membrane protein of
A4E84_RS19860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4E84_RS19865	COG0626	cystathionine gamma-synthase activity
A4E84_RS19895	COG2814	Major facilitator Superfamily
A4E84_RS19920	COG0305	Participates in initiation and elongation during chromosome replication
A4E84_RS19925	COG0534	Mate efflux family protein
A4E84_RS19930	COG0359	binds to the 23S rRNA
A4E84_RS19935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4E84_RS19940	COG0629	single-stranded DNA binding
A4E84_RS19945	COG0360	Binds together with S18 to 16S ribosomal RNA
A4E84_RS19970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4E84_RS19990	COG0617	tRNA 3'-terminal CCA addition
A4E84_RS20005	COG0515	serine threonine protein kinase
A4E84_RS20005	COG2815	serine threonine protein kinase
A4E84_RS20010	COG1595	DNA-templated transcription, initiation
A4E84_RS20020	COG0492	ferredoxin-NADP+ reductase activity
A4E84_RS20025	COG3118	belongs to the thioredoxin family
A4E84_RS20040	COG1192	Involved in chromosome partitioning
A4E84_RS20045	COG0357	Ribosomal RNA small subunit methyltransferase G
A4E84_RS20055	COG0706	membrane insertase activity
A4E84_RS20060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4E84_RS20065	COG0592	DNA-directed DNA polymerase activity
A4E84_RS20070	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A4E84_RS20075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4E84_RS20080	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A4E84_RS20085	COG0187	DNA topoisomerase II activity
A4E84_RS20090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4E84_RS20110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4E84_RS20480	COG0582	viral genome integration into host DNA
A4E84_RS20500	COG0515	serine threonine protein kinase
A4E84_RS20525	COG0705	Rhomboid family
A4E84_RS20540	COG3764	Sortase (surface protein transpeptidase)
A4E84_RS20555	COG3764	Sortase (surface protein transpeptidase)
A4E84_RS20560	COG3764	Sortase (surface protein transpeptidase)
A4E84_RS20570	COG0515	serine threonine protein kinase
A4E84_RS20575	COG0768	penicillin binding
A4E84_RS20590	COG1716	ATPase activity
A4E84_RS20595	COG1716	ATPase activity
A4E84_RS20620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4E84_RS20675	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4E84_RS20680	COG1309	transcriptional regulator
A4E84_RS20685	COG1522	sequence-specific DNA binding
A4E84_RS20705	COG0746	molybdenum cofactor guanylyltransferase activity
A4E84_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS20730	COG3321	synthase
A4E84_RS20730	COG0604	alcohol dehydrogenase
A4E84_RS20745	COG0515	serine threonine protein kinase
A4E84_RS20750	COG0515	serine threonine protein kinase
A4E84_RS20760	COG0022	dehydrogenase e1 component
A4E84_RS20765	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4E84_RS20770	COG3409	Peptidoglycan-binding domain 1 protein
A4E84_RS20795	COG2890	protein-(glutamine-N5) methyltransferase activity
A4E84_RS20830	COG1362	aminopeptidase activity
A4E84_RS20835	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS20855	COG0477	Major facilitator Superfamily
A4E84_RS20860	COG1741	Belongs to the pirin family
A4E84_RS20875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4E84_RS20905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4E84_RS20925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4E84_RS20930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4E84_RS20975	COG0701	Predicted permease
A4E84_RS20995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4E84_RS21005	COG1957	nucleoside hydrolase
A4E84_RS21015	COG0366	Alpha amylase catalytic
A4E84_RS21040	COG1309	transcriptional regulator
A4E84_RS21045	COG1132	(ABC) transporter
A4E84_RS21065	COG2367	Beta-lactamase
A4E84_RS21115	COG0714	Associated with various cellular activities
A4E84_RS21135	COG2267	carboxylic ester hydrolase activity
A4E84_RS21145	COG1733	regulation of RNA biosynthetic process
A4E84_RS21195	COG1609	Transcriptional regulator
A4E84_RS21205	COG0513	Belongs to the DEAD box helicase family
A4E84_RS21210	COG1278	Cold shock
A4E84_RS21215	COG2409	Drug exporters of the RND superfamily
A4E84_RS21220	COG4585	Histidine kinase
A4E84_RS21225	COG2197	response regulator
A4E84_RS21235	COG2197	response regulator
A4E84_RS21240	COG4585	Histidine kinase
A4E84_RS21245	COG0640	Transcriptional regulator
A4E84_RS21280	COG0583	DNA-binding transcription factor activity
A4E84_RS21295	COG0431	NADPH-dependent FMN reductase
A4E84_RS21295	COG3976	FMN-binding domain protein
A4E84_RS21295	COG1053	succinate dehydrogenase
A4E84_RS21300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4E84_RS21320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4E84_RS21325	COG0583	DNA-binding transcription factor activity
A4E84_RS21335	COG1024	Enoyl-CoA hydratase
A4E84_RS21345	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4E84_RS21350	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS21360	COG0475	glutathione-regulated potassium exporter activity
A4E84_RS21400	COG0513	Belongs to the DEAD box helicase family
A4E84_RS21405	COG1278	Cold shock
A4E84_RS21410	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS21415	COG0583	DNA-binding transcription factor activity
A4E84_RS21500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4E84_RS21510	COG1115	amino acid carrier protein
A4E84_RS21510	COG1115	amino acid carrier protein
A4E84_RS21615	COG1131	(ABC) transporter
A4E84_RS21625	COG1595	DNA-templated transcription, initiation
A4E84_RS21635	COG3345	alpha-galactosidase
A4E84_RS21645	COG0717	Belongs to the dCTP deaminase family
A4E84_RS21650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A4E84_RS21690	COG0247	lactate metabolic process
A4E84_RS21690	COG2181	nitrate reductase activity
A4E84_RS21695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4E84_RS21700	COG0443	Heat shock 70 kDa protein
A4E84_RS21705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4E84_RS21710	COG0484	heat shock protein binding
A4E84_RS21715	COG0789	Transcriptional regulator
A4E84_RS21720	COG4213	ABC transporter substrate-binding protein
A4E84_RS21750	COG0542	response to heat
A4E84_RS21785	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A4E84_RS21800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4E84_RS21810	COG0477	Major facilitator Superfamily
A4E84_RS21825	COG3844	kynureninase activity
A4E84_RS21845	COG4585	Histidine kinase
A4E84_RS21850	COG2197	response regulator
A4E84_RS21855	COG4585	Histidine kinase
A4E84_RS21860	COG2197	response regulator
A4E84_RS21865	COG2124	cytochrome p450
A4E84_RS21870	COG3559	Exporter of polyketide antibiotics
A4E84_RS21875	COG1131	(ABC) transporter
A4E84_RS21890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4E84_RS21905	COG1802	Transcriptional regulator
A4E84_RS21910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4E84_RS21915	COG0693	protein deglycase activity
A4E84_RS21930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4E84_RS21940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4E84_RS21945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4E84_RS21965	COG2205	protein histidine kinase activity
A4E84_RS21970	COG0745	RESPONSE REGULATOR receiver
A4E84_RS21985	COG1595	DNA-templated transcription, initiation
A4E84_RS22010	COG0701	Predicted permease
A4E84_RS22055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4E84_RS22075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4E84_RS22100	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS22105	COG0028	Belongs to the TPP enzyme family
A4E84_RS22110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4E84_RS22200	COG1725	Transcriptional regulator
A4E84_RS22225	COG1674	ftsk spoiiie
A4E84_RS22245	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4E84_RS22285	COG1408	metallophosphoesterase
A4E84_RS22295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4E84_RS22305	COG0003	Pfam Anion-transporting ATPase
A4E84_RS22325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4E84_RS22360	COG2267	carboxylic ester hydrolase activity
A4E84_RS22370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4E84_RS22375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4E84_RS22430	COG1205	dead DEAH box helicase
A4E84_RS22430	COG1111	helicase
A4E84_RS22435	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS22445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A4E84_RS22465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4E84_RS22465	COG1754	DNA topoisomerase type I activity
A4E84_RS22470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4E84_RS22490	COG0577	efflux transmembrane transporter activity
A4E84_RS22495	COG1136	(ABC) transporter
A4E84_RS22495	COG0577	efflux transmembrane transporter activity
A4E84_RS22505	COG2197	response regulator
A4E84_RS22515	COG3708	Transcriptional regulator
A4E84_RS22515	COG2207	Transcriptional regulator
A4E84_RS22525	COG3629	intracellular signal transduction
A4E84_RS22525	COG3903	Transcriptional regulator
A4E84_RS22530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4E84_RS22530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4E84_RS22555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4E84_RS22560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4E84_RS22565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4E84_RS22570	COG0254	rRNA binding
A4E84_RS22580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4E84_RS22605	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS22610	COG2318	DinB family
A4E84_RS22630	COG0076	glutamate decarboxylase activity
A4E84_RS22640	COG0789	Transcriptional regulator
A4E84_RS22645	COG0393	Putative heavy-metal-binding
A4E84_RS22650	COG0586	Pfam SNARE associated Golgi protein
A4E84_RS22660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4E84_RS22665	COG2027	D-alanyl-D-alanine carboxypeptidase
A4E84_RS22675	COG0037	tRNA processing
A4E84_RS22690	COG0302	gtp cyclohydrolase
A4E84_RS22705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4E84_RS22720	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4E84_RS22720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4E84_RS22745	COG0649	NAD binding
A4E84_RS22760	COG2197	response regulator
A4E84_RS22765	COG0640	Transcriptional regulator
A4E84_RS22780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4E84_RS22785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4E84_RS22795	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4E84_RS22815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4E84_RS22845	COG0739	heme binding
A4E84_RS22860	COG2205	protein histidine kinase activity
A4E84_RS22865	COG0745	RESPONSE REGULATOR receiver
A4E84_RS22875	COG1595	DNA-templated transcription, initiation
A4E84_RS22880	COG1194	a g-specific adenine glycosylase
A4E84_RS22885	COG4585	Histidine kinase
A4E84_RS22895	COG0671	phosphoesterase, PA-phosphatase related
A4E84_RS22905	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A4E84_RS22925	COG0248	Ppx GppA phosphatase
A4E84_RS22930	COG1082	Xylose isomerase domain protein TIM barrel
A4E84_RS22940	COG0129	dihydroxy-acid dehydratase activity
A4E84_RS22950	COG4991	sh3 domain protein
A4E84_RS22975	COG0842	Transport permease protein
A4E84_RS22975	COG1129	ABC transporter
A4E84_RS22985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4E84_RS22990	COG0180	Tryptophanyl-tRNA synthetase
A4E84_RS23025	COG0123	including yeast histone deacetylase and acetoin utilization protein
A4E84_RS23070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4E84_RS23075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4E84_RS23080	COG0181	hydroxymethylbilane synthase activity
A4E84_RS23085	COG1648	precorrin-2 dehydrogenase activity
A4E84_RS23085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4E84_RS23095	COG0113	porphobilinogen synthase activity
A4E84_RS23110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4E84_RS23120	COG0483	inositol monophosphate 1-phosphatase activity
A4E84_RS23125	COG3903	Transcriptional regulator
A4E84_RS23125	COG3629	intracellular signal transduction
A4E84_RS23140	COG2318	DinB family
A4E84_RS23150	COG0018	arginyl-trna synthetase
A4E84_RS23155	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A4E84_RS23175	COG1690	Belongs to the RtcB family
A4E84_RS23190	COG1742	UPF0060 membrane protein
A4E84_RS23195	COG1733	regulation of RNA biosynthetic process
A4E84_RS23200	COG0604	alcohol dehydrogenase
A4E84_RS23205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS23215	COG2205	protein histidine kinase activity
A4E84_RS23235	COG0477	Major facilitator Superfamily
A4E84_RS23250	COG2197	response regulator
A4E84_RS23255	COG4585	Histidine kinase
A4E84_RS23260	COG1132	(ABC) transporter
A4E84_RS23280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4E84_RS23285	COG0406	alpha-ribazole phosphatase activity
A4E84_RS23295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4E84_RS23300	COG0785	Cytochrome C biogenesis protein
A4E84_RS23305	COG1333	cytochrome c biogenesis protein
A4E84_RS23310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4E84_RS23330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4E84_RS23350	COG2318	DinB family
A4E84_RS23360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4E84_RS23365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4E84_RS23375	COG0163	prenyltransferase activity
A4E84_RS23385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4E84_RS23390	COG1573	uracil-dna glycosylase
A4E84_RS23405	COG1301	dicarboxylic acid transport
A4E84_RS23410	COG1309	transcriptional regulator
A4E84_RS23425	COG0183	Belongs to the thiolase family
A4E84_RS23435	COG4213	ABC transporter substrate-binding protein
A4E84_RS23440	COG1053	succinate dehydrogenase
A4E84_RS23445	COG2226	methyltransferase
A4E84_RS23450	COG1278	Cold shock
A4E84_RS23455	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A4E84_RS23575	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A4E84_RS23620	COG3209	COG3209 Rhs family protein
A4E84_RS23620	COG4104	PAAR repeat-containing protein
A4E84_RS23650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4E84_RS23660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4E84_RS23670	COG3979	chitinase
A4E84_RS23675	COG2226	methyltransferase
A4E84_RS23710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23720	COG0649	NAD binding
A4E84_RS23730	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4E84_RS23735	COG1034	ATP synthesis coupled electron transport
A4E84_RS23740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4E84_RS23745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23750	COG0839	Belongs to the complex I subunit 6 family
A4E84_RS23755	COG0713	ATP synthesis coupled electron transport
A4E84_RS23760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4E84_RS23770	COG1007	ATP synthesis coupled electron transport
A4E84_RS23820	COG1216	Glycosyl transferase, family 2
A4E84_RS23830	COG0561	phosphatase activity
A4E84_RS23840	COG0142	geranyltranstransferase activity
A4E84_RS23850	COG1131	(ABC) transporter
A4E84_RS23880	COG4935	Belongs to the peptidase S8 family
A4E84_RS23880	COG2234	aminopeptidase activity
A4E84_RS23895	COG1733	regulation of RNA biosynthetic process
A4E84_RS23915	COG0702	epimerase
A4E84_RS23920	COG1733	regulation of RNA biosynthetic process
A4E84_RS23925	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4E84_RS23930	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4E84_RS23930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4E84_RS23950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4E84_RS23970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23975	COG0839	Belongs to the complex I subunit 6 family
A4E84_RS23980	COG0713	ATP synthesis coupled electron transport
A4E84_RS23985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4E84_RS23990	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4E84_RS23995	COG1007	ATP synthesis coupled electron transport
A4E84_RS24000	COG0501	Belongs to the peptidase M48B family
A4E84_RS24005	COG3304	Inner membrane component domain
A4E84_RS24015	COG2261	transglycosylase associated protein
A4E84_RS24020	COG1666	GTP binding
A4E84_RS24035	COG0702	epimerase
A4E84_RS24055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4E84_RS24060	COG2030	dehydratase
A4E84_RS24075	COG0477	Major facilitator Superfamily
A4E84_RS24085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4E84_RS24095	COG1733	regulation of RNA biosynthetic process
A4E84_RS24110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4E84_RS24115	COG0436	Aminotransferase
A4E84_RS24125	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4E84_RS24130	COG0250	Participates in transcription elongation, termination and antitermination
A4E84_RS24135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4E84_RS24140	COG0081	regulation of translation
A4E84_RS24155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4E84_RS24160	COG0222	ribosome binding
A4E84_RS24165	COG0085	RNA polymerase activity
A4E84_RS24170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4E84_RS24180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4E84_RS24185	COG0049	tRNA binding
A4E84_RS24190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4E84_RS24195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4E84_RS24250	COG2732	(Barnase) inhibitor
A4E84_RS24255	COG0051	transcription antitermination factor activity, RNA binding
A4E84_RS24260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4E84_RS24265	COG0088	Forms part of the polypeptide exit tunnel
A4E84_RS24270	COG0089	rRNA binding
A4E84_RS24275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4E84_RS24280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4E84_RS24285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4E84_RS24290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4E84_RS24295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4E84_RS24300	COG0255	Belongs to the universal ribosomal protein uL29 family
A4E84_RS24305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4E84_RS24310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4E84_RS24315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4E84_RS24320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4E84_RS24325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4E84_RS24330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4E84_RS24335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4E84_RS24340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4E84_RS24345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4E84_RS24350	COG1841	ribosomal large subunit assembly
A4E84_RS24355	COG0200	Binds to the 23S rRNA
A4E84_RS24365	COG0563	adenylate kinase activity
A4E84_RS24375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4E84_RS24380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4E84_RS24385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4E84_RS24390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4E84_RS24395	COG0202	RNA polymerase activity
A4E84_RS24400	COG0203	ribosomal protein L17
A4E84_RS24405	COG0101	tRNA pseudouridine synthase activity
A4E84_RS24420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4E84_RS24425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4E84_RS24430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4E84_RS24440	COG1072	(Pantothenic acid kinase))
A4E84_RS24455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4E84_RS24465	COG0736	holo-[acyl-carrier-protein] synthase activity
A4E84_RS24490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4E84_RS24500	COG0802	atpase or kinase
A4E84_RS24510	COG0456	acetyltransferase
A4E84_RS24510	COG1214	PFAM Peptidase M22, glycoprotease
A4E84_RS24520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4E84_RS24535	COG1609	Transcriptional regulator
A4E84_RS24545	COG1316	TRANSCRIPTIONal
A4E84_RS24555	COG4941	Belongs to the sigma-70 factor family
A4E84_RS24565	COG0726	polysaccharide deacetylase
A4E84_RS24570	COG0726	polysaccharide deacetylase
A4E84_RS24575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4E84_RS24580	COG0459	protein refolding
A4E84_RS24590	COG4221	oxidoreductase activity
A4E84_RS24600	COG0583	DNA-binding transcription factor activity
A4E84_RS24615	COG1595	DNA-templated transcription, initiation
A4E84_RS24625	COG0516	GMP reductase activity
A4E84_RS24635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4E84_RS24650	COG0515	serine threonine protein kinase
A4E84_RS24650	COG2815	serine threonine protein kinase
A4E84_RS24655	COG0515	serine threonine protein kinase
A4E84_RS24660	COG2815	serine threonine protein kinase
A4E84_RS24660	COG0515	serine threonine protein kinase
A4E84_RS24665	COG0515	serine threonine protein kinase
A4E84_RS24670	COG0515	serine threonine protein kinase
A4E84_RS24675	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS24700	COG0519	Catalyzes the synthesis of GMP from XMP
A4E84_RS24700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4E84_RS24745	COG2197	response regulator
A4E84_RS24750	COG0791	NLP P60 protein
A4E84_RS24825	COG0739	heme binding
A4E84_RS24830	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4E84_RS24835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS24835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS24850	COG0714	Associated with various cellular activities
A4E84_RS24860	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4E84_RS24865	COG0045	succinate-CoA ligase (ADP-forming) activity
A4E84_RS24895	COG0138	bifunctional purine biosynthesis protein purh
A4E84_RS24910	COG2815	serine threonine protein kinase
A4E84_RS24910	COG0515	serine threonine protein kinase
A4E84_RS24920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4E84_RS24935	COG0039	L-malate dehydrogenase activity
A4E84_RS24940	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS24950	COG4175	Glycine betaine
A4E84_RS24950	COG0517	IMP dehydrogenase activity
A4E84_RS24955	COG4176	ABC-type proline glycine betaine transport system permease component
A4E84_RS24970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4E84_RS24975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4E84_RS24980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4E84_RS24990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4E84_RS25000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4E84_RS25005	COG0512	Glutamine amidotransferase of anthranilate synthase
A4E84_RS25005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4E84_RS25025	COG0754	glutathionylspermidine amidase activity
A4E84_RS25030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4E84_RS25040	COG0180	Tryptophanyl-tRNA synthetase
A4E84_RS25075	COG1295	ribonuclease BN
A4E84_RS25080	COG1686	Belongs to the peptidase S11 family
A4E84_RS25105	COG1309	transcriptional regulator
A4E84_RS25130	COG1053	succinate dehydrogenase
A4E84_RS25140	COG2009	succinate dehydrogenase
A4E84_RS25200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS25200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS25220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4E84_RS25230	COG1216	Glycosyl transferase, family 2
A4E84_RS25245	COG2089	acid synthase
A4E84_RS25255	COG4106	trans-aconitate 2-methyltransferase activity
A4E84_RS25260	COG1473	amidohydrolase
A4E84_RS25260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4E84_RS25265	COG1744	ABC transporter substrate-binding protein PnrA-like
A4E84_RS25270	COG1744	ABC transporter substrate-binding protein PnrA-like
A4E84_RS25275	COG3845	ABC transporter
A4E84_RS25285	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS25305	COG0592	DNA-directed DNA polymerase activity
A4E84_RS25310	COG2814	Major facilitator Superfamily
A4E84_RS25315	COG0583	DNA-binding transcription factor activity
A4E84_RS25325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4E84_RS25350	COG2205	protein histidine kinase activity
A4E84_RS25355	COG0745	RESPONSE REGULATOR receiver
A4E84_RS25360	COG1595	DNA-templated transcription, initiation
A4E84_RS25375	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS25380	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS25395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4E84_RS25420	COG4770	biotin carboxylase activity
A4E84_RS25430	COG0424	maF-like protein
A4E84_RS25440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4E84_RS25450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4E84_RS25460	COG1024	Enoyl-CoA hydratase
A4E84_RS25470	COG2986	histidine ammonia-lyase
A4E84_RS25490	COG1404	Belongs to the peptidase S8 family
A4E84_RS25500	COG1064	alcohol dehydrogenase
A4E84_RS25510	COG1090	epimerase
A4E84_RS25530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4E84_RS25555	COG2255	four-way junction helicase activity
A4E84_RS25560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4E84_RS25575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4E84_RS25585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4E84_RS25615	COG1331	Highly conserved protein containing a thioredoxin domain
A4E84_RS25645	COG1309	transcriptional regulator
A4E84_RS25650	COG0477	Major facilitator Superfamily
A4E84_RS25660	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4E84_RS25665	COG3409	Peptidoglycan-binding domain 1 protein
A4E84_RS25695	COG1136	(ABC) transporter
A4E84_RS25695	COG0577	efflux transmembrane transporter activity
A4E84_RS25700	COG1136	(ABC) transporter
A4E84_RS25700	COG0577	efflux transmembrane transporter activity
A4E84_RS25710	COG0436	Aminotransferase
A4E84_RS25725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A4E84_RS25740	COG1414	Transcriptional regulator
A4E84_RS25745	COG0251	oxidation-reduction process
A4E84_RS25800	COG2894	cell division
A4E84_RS25830	COG3920	Histidine kinase
A4E84_RS25835	COG2197	response regulator
A4E84_RS25895	COG2226	methyltransferase
A4E84_RS25905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4E84_RS25910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4E84_RS25925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4E84_RS25930	COG0450	alkyl hydroperoxide reductase
A4E84_RS25945	COG1136	(ABC) transporter
A4E84_RS25965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4E84_RS25975	COG3409	Peptidoglycan-binding domain 1 protein
A4E84_RS26000	COG0114	fumarate hydratase activity
A4E84_RS26005	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4E84_RS26005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4E84_RS26030	COG0778	Nitroreductase
A4E84_RS26035	COG1722	exodeoxyribonuclease VII activity
A4E84_RS26040	COG1570	exodeoxyribonuclease VII activity
A4E84_RS26045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4E84_RS26060	COG0012	GTP binding
A4E84_RS26080	COG1595	DNA-templated transcription, initiation
A4E84_RS26095	COG2226	methyltransferase
A4E84_RS26100	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A4E84_RS26120	COG0142	geranyltranstransferase activity
A4E84_RS26130	COG0702	epimerase
A4E84_RS26135	COG2409	Drug exporters of the RND superfamily
A4E84_RS26140	COG1846	Transcriptional regulator
A4E84_RS26160	COG2197	response regulator
A4E84_RS26165	COG4585	Histidine kinase
A4E84_RS26215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4E84_RS26245	COG1217	gtp-binding protein TYPA
A4E84_RS26255	COG0601	transmembrane transport
A4E84_RS26260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4E84_RS26270	COG4608	Belongs to the ABC transporter superfamily
A4E84_RS26295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4E84_RS26310	COG1131	(ABC) transporter
A4E84_RS26320	COG4585	Histidine kinase
A4E84_RS26325	COG2197	response regulator
A4E84_RS26360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4E84_RS26370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4E84_RS26380	COG2818	Glycosylase
A4E84_RS26385	COG1024	Enoyl-CoA hydratase
A4E84_RS26395	COG1595	DNA-templated transcription, initiation
A4E84_RS26405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4E84_RS26410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4E84_RS26445	COG0598	Magnesium transport protein CorA
A4E84_RS26455	COG2814	Major facilitator Superfamily
A4E84_RS26470	COG2095	MarC family integral membrane protein
A4E84_RS26475	COG3591	Belongs to the peptidase S1B family
A4E84_RS26475	COG1864	DNA RNA non-specific endonuclease
A4E84_RS26480	COG1432	Conserved Protein
A4E84_RS26560	COG0596	Alpha beta hydrolase
A4E84_RS26585	COG0210	DNA helicase
A4E84_RS26590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4E84_RS26625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4E84_RS26675	COG3480	Lon protease (S16) C-terminal proteolytic domain
A4E84_RS26685	COG1615	UPF0182 protein
A4E84_RS26710	COG0753	catalase activity
A4E84_RS26720	COG0483	inositol monophosphate 1-phosphatase activity
A4E84_RS26755	COG1162	GTPase activity
A4E84_RS26760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4E84_RS26770	COG2135	peptidase activity
A4E84_RS26780	COG1595	DNA-templated transcription, initiation
A4E84_RS26785	COG5662	AntiSigma factor
A4E84_RS26790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A4E84_RS26790	COG2199	diguanylate cyclase activity
A4E84_RS26805	COG0242	peptide deformylase activity
A4E84_RS26815	COG2124	cytochrome p450
A4E84_RS26850	COG2188	Transcriptional regulator
A4E84_RS26855	COG2182	Extracellular solute-binding protein
A4E84_RS26860	COG1175	transmembrane transport
A4E84_RS26865	COG0395	ABC-type sugar transport system, permease component
A4E84_RS26870	COG1472	Belongs to the glycosyl hydrolase 3 family
A4E84_RS26875	COG1476	TRANSCRIPTIONal
A4E84_RS26885	COG0363	glucosamine-6-phosphate deaminase activity
A4E84_RS26890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4E84_RS26895	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS26900	COG1309	transcriptional regulator
A4E84_RS26915	COG1597	lipid kinase activity
A4E84_RS26945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4E84_RS26950	COG0142	geranyltranstransferase activity
A4E84_RS26965	COG4941	Belongs to the sigma-70 factor family
A4E84_RS27000	COG4106	trans-aconitate 2-methyltransferase activity
A4E84_RS27005	COG1126	abc transporter atp-binding protein
A4E84_RS27020	COG0281	malic enzyme
A4E84_RS27025	COG0604	alcohol dehydrogenase
A4E84_RS27060	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4E84_RS27060	COG0567	Dehydrogenase, E1 component
A4E84_RS27065	COG2205	protein histidine kinase activity
A4E84_RS27070	COG0745	RESPONSE REGULATOR receiver
A4E84_RS27090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4E84_RS27130	COG3883	PFAM NLP P60 protein
A4E84_RS27130	COG0791	NLP P60 protein
A4E84_RS27140	COG1309	transcriptional regulator
A4E84_RS27170	COG2205	protein histidine kinase activity
A4E84_RS27190	COG1793	dna ligase
A4E84_RS27190	COG3285	dna ligase
A4E84_RS27195	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4E84_RS27200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4E84_RS27225	COG3265	gluconokinase activity
A4E84_RS27235	COG1063	alcohol dehydrogenase
A4E84_RS27240	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
A4E84_RS27260	COG3629	intracellular signal transduction
A4E84_RS27260	COG3903	Transcriptional regulator
A4E84_RS27305	COG0583	DNA-binding transcription factor activity
A4E84_RS27325	COG0018	arginyl-trna synthetase
A4E84_RS27330	COG0019	diaminopimelate decarboxylase activity
A4E84_RS27335	COG0460	homoserine dehydrogenase
A4E84_RS27340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4E84_RS27345	COG0083	homoserine kinase activity
A4E84_RS27365	COG0254	rRNA binding
A4E84_RS27370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4E84_RS27375	COG2890	protein-(glutamine-N5) methyltransferase activity
A4E84_RS27385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4E84_RS27390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4E84_RS27395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4E84_RS27410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4E84_RS27415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4E84_RS27420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4E84_RS27425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4E84_RS27430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4E84_RS27435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4E84_RS27440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4E84_RS27455	COG2197	response regulator
A4E84_RS27460	COG4585	Histidine kinase
A4E84_RS27485	COG1309	transcriptional regulator
A4E84_RS27490	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4E84_RS27505	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A4E84_RS27540	COG1131	(ABC) transporter
A4E84_RS27560	COG0183	Belongs to the thiolase family
A4E84_RS27575	COG0745	RESPONSE REGULATOR receiver
A4E84_RS27580	COG2205	protein histidine kinase activity
A4E84_RS27630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS27630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS27670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4E84_RS27675	COG0280	phosphate acetyltransferase
A4E84_RS27675	COG0857	belongs to the CobB CobQ family
A4E84_RS27680	COG0205	6-phosphofructokinase activity
A4E84_RS27695	COG4565	transcriptional regulatory protein
A4E84_RS27700	COG3290	protein histidine kinase activity
A4E84_RS27705	COG1301	dicarboxylic acid transport
A4E84_RS27715	COG0477	Major facilitator Superfamily
A4E84_RS27720	COG0667	Aldo Keto reductase
A4E84_RS27730	COG1522	sequence-specific DNA binding
A4E84_RS27755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4E84_RS27760	COG3281	Trehalose synthase
A4E84_RS27780	COG0058	SHG alpha-glucan phosphorylase activity
A4E84_RS27800	COG1132	(ABC) transporter
A4E84_RS27805	COG1132	(ABC) transporter
A4E84_RS27810	COG1132	(ABC) transporter
A4E84_RS27820	COG1131	(ABC) transporter
A4E84_RS27830	COG4585	Histidine kinase
A4E84_RS27835	COG2197	response regulator
A4E84_RS27860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4E84_RS27940	COG1401	restriction endodeoxyribonuclease activity
A4E84_RS27955	COG2755	lipolytic protein G-D-S-L family
A4E84_RS27965	COG1760	l-serine dehydratase
A4E84_RS27970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4E84_RS27975	COG0509	glycine decarboxylation via glycine cleavage system
A4E84_RS27980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4E84_RS28000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4E84_RS28005	COG0747	negative chemotaxis
A4E84_RS28020	COG4608	Belongs to the ABC transporter superfamily
A4E84_RS28025	COG2860	membrane
A4E84_RS28040	COG1309	transcriptional regulator
A4E84_RS28060	COG0482	sulfurtransferase activity
A4E84_RS28080	COG1611	Belongs to the LOG family
A4E84_RS28085	COG4221	oxidoreductase activity
A4E84_RS28095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4E84_RS28105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4E84_RS28110	COG0154	amidase activity
A4E84_RS28120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4E84_RS28125	COG2226	methyltransferase
A4E84_RS28135	COG2409	Drug exporters of the RND superfamily
A4E84_RS28140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4E84_RS28165	COG2133	pyrroloquinoline quinone binding
A4E84_RS28170	COG0667	Aldo Keto reductase
A4E84_RS28180	COG5001	Diguanylate cyclase
A4E84_RS28190	COG0440	acetolactate synthase activity
A4E84_RS28195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4E84_RS28205	COG0477	Major facilitator Superfamily
A4E84_RS28215	COG4608	Belongs to the ABC transporter superfamily
A4E84_RS28225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4E84_RS28230	COG0747	negative chemotaxis
A4E84_RS28240	COG3835	regulator
A4E84_RS28245	COG0506	proline dehydrogenase activity
A4E84_RS28250	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS28265	COG0473	3-isopropylmalate dehydrogenase activity
A4E84_RS28270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4E84_RS28280	COG0831	urea catabolic process
A4E84_RS28280	COG0832	Belongs to the urease beta subunit family
A4E84_RS28285	COG0804	urea catabolic process
A4E84_RS28290	COG2957	Belongs to the agmatine deiminase family
A4E84_RS28305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4E84_RS28330	COG2353	YceI-like domain
A4E84_RS28335	COG0300	oxidoreductase activity
A4E84_RS28340	COG5492	domain, Protein
A4E84_RS28345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4E84_RS28365	COG2018	Roadblock/LC7 domain
A4E84_RS28385	COG2018	Roadblock/LC7 domain
A4E84_RS28390	COG5002	protein histidine kinase activity
A4E84_RS28400	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4E84_RS28405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4E84_RS28445	COG1414	Transcriptional regulator
A4E84_RS28450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4E84_RS28455	COG0066	3-isopropylmalate dehydratase activity
A4E84_RS28465	COG0776	regulation of translation
A4E84_RS28475	COG1920	GTP binding
A4E84_RS28485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4E84_RS28490	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4E84_RS28510	COG0351	phosphomethylpyrimidine kinase
A4E84_RS28515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4E84_RS28520	COG1461	Dihydroxyacetone kinase
A4E84_RS28530	COG0326	Molecular chaperone. Has ATPase activity
A4E84_RS28540	COG0742	ribosomal rna small subunit methyltransferase
A4E84_RS28545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4E84_RS28555	COG1399	metal-binding, possibly nucleic acid-binding protein
A4E84_RS28560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4E84_RS28565	COG0571	ribonuclease III activity
A4E84_RS28570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4E84_RS28575	COG1733	regulation of RNA biosynthetic process
A4E84_RS28580	COG2340	Cysteine-rich secretory protein family
A4E84_RS28585	COG1254	Belongs to the acylphosphatase family
A4E84_RS28595	COG1196	nuclear chromosome segregation
A4E84_RS28600	COG0477	Major facilitator Superfamily
A4E84_RS28635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4E84_RS28665	COG0228	four-way junction DNA binding
A4E84_RS28670	COG1837	Belongs to the UPF0109 family
A4E84_RS28675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4E84_RS28680	COG0336	Belongs to the RNA methyltransferase TrmD family
A4E84_RS28685	COG0335	large ribosomal subunit rRNA binding
A4E84_RS28700	COG0681	Belongs to the peptidase S26 family
A4E84_RS28720	COG0792	nuclease activity
A4E84_RS28735	COG1191	sigma factor activity
A4E84_RS28745	COG4942	peptidase
A4E84_RS28750	COG0052	Belongs to the universal ribosomal protein uS2 family
A4E84_RS28755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4E84_RS28760	COG0528	UMP kinase activity
A4E84_RS28765	COG0233	cytoplasmic translational termination
A4E84_RS28770	COG0575	Belongs to the CDS family
A4E84_RS28830	COG2188	Transcriptional regulator
A4E84_RS28835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4E84_RS28855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4E84_RS28865	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4E84_RS28870	COG3842	ATPase activity
A4E84_RS28900	COG1136	(ABC) transporter
A4E84_RS28905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4E84_RS28915	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS28935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4E84_RS28965	COG3842	ATPase activity
A4E84_RS28970	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4E84_RS28975	COG1177	transmembrane transport
A4E84_RS28980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4E84_RS29010	COG2508	Transcriptional regulator
A4E84_RS29010	COG2508	Transcriptional regulator
A4E84_RS29015	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS29030	COG4209	transmembrane transport
A4E84_RS29035	COG0395	ABC-type sugar transport system, permease component
A4E84_RS29080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4E84_RS29085	COG0750	zinc metalloprotease
A4E84_RS29090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4E84_RS29105	COG0442	prolyl-tRNA aminoacylation
A4E84_RS29125	COG0779	Required for maturation of 30S ribosomal subunits
A4E84_RS29145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4E84_RS29150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4E84_RS29185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4E84_RS29190	COG0601	transmembrane transport
A4E84_RS29195	COG0747	negative chemotaxis
A4E84_RS29200	COG0455	bacterial-type flagellum organization
A4E84_RS29225	COG1404	Belongs to the peptidase S8 family
A4E84_RS29265	COG1674	ftsk spoiiie
A4E84_RS29280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4E84_RS29285	COG1185	polyribonucleotide nucleotidyltransferase activity
A4E84_RS29290	COG0612	Peptidase, M16
A4E84_RS29295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4E84_RS29315	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A4E84_RS29320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4E84_RS29325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4E84_RS29360	COG2770	Histidine kinase
A4E84_RS29360	COG2208	phosphoserine phosphatase activity
A4E84_RS29365	COG2205	protein histidine kinase activity
A4E84_RS29365	COG0784	Response regulator, receiver
A4E84_RS29375	COG1674	ftsk spoiiie
A4E84_RS29385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4E84_RS29395	COG1546	Belongs to the CinA family
A4E84_RS29395	COG1058	Belongs to the CinA family
A4E84_RS29400	COG1396	sequence-specific DNA binding
A4E84_RS29405	COG0783	Belongs to the Dps family
A4E84_RS29415	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS29420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4E84_RS29425	COG1201	RNA secondary structure unwinding
A4E84_RS29455	COG0628	permease
A4E84_RS29465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4E84_RS29475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4E84_RS29490	COG0765	amino acid transport
A4E84_RS29495	COG0765	amino acid transport
A4E84_RS29500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4E84_RS29505	COG1126	abc transporter atp-binding protein
A4E84_RS29510	COG0745	RESPONSE REGULATOR receiver
A4E84_RS29515	COG2205	protein histidine kinase activity
A4E84_RS29520	COG2358	TRAP transporter, solute receptor (TAXI family
A4E84_RS29540	COG3851	Histidine kinase
A4E84_RS29545	COG2197	response regulator
A4E84_RS29550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4E84_RS29570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4E84_RS29580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4E84_RS29585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4E84_RS29595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4E84_RS29635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4E84_RS29640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4E84_RS29645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4E84_RS29660	COG0588	phosphoglycerate mutase activity
A4E84_RS29905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4E84_RS29940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4E84_RS29945	COG2186	Transcriptional regulator
A4E84_RS29950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4E84_RS29965	COG0187	DNA topoisomerase II activity
A4E84_RS29975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4E84_RS29980	COG4565	transcriptional regulatory protein
A4E84_RS29985	COG3290	protein histidine kinase activity
A4E84_RS30000	COG0372	Belongs to the citrate synthase family
A4E84_RS30010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4E84_RS30015	COG0612	Peptidase, M16
A4E84_RS30030	COG1802	Transcriptional regulator
A4E84_RS30035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4E84_RS30040	COG0045	succinate-CoA ligase (ADP-forming) activity
A4E84_RS30040	COG1042	CoA-binding domain protein
A4E84_RS30040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4E84_RS30055	COG1435	thymidine kinase activity
A4E84_RS30085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A4E84_RS30095	COG0745	RESPONSE REGULATOR receiver
A4E84_RS30100	COG2205	protein histidine kinase activity
A4E84_RS30125	COG0756	dUTP diphosphatase activity
A4E84_RS30165	COG0569	domain protein
A4E84_RS30175	COG0531	amino acid
A4E84_RS30180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4E84_RS30190	COG3654	unkown
A4E84_RS30200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4E84_RS30205	COG0778	Nitroreductase
A4E84_RS30245	COG2197	response regulator
A4E84_RS30250	COG4585	Histidine kinase
A4E84_RS30260	COG1609	Transcriptional regulator
A4E84_RS30290	COG1621	beta-fructofuranosidase activity
A4E84_RS30370	COG2084	Dehydrogenase
A4E84_RS30385	COG3321	synthase
A4E84_RS30385	COG0604	alcohol dehydrogenase
A4E84_RS30385	COG3321	synthase
A4E84_RS30385	COG0604	alcohol dehydrogenase
A4E84_RS30420	COG3594	Acyltransferase
A4E84_RS30455	COG2353	YceI-like domain
A4E84_RS30465	COG0243	molybdopterin cofactor binding
A4E84_RS30470	COG1799	cell septum assembly
A4E84_RS30500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4E84_RS30510	COG2255	four-way junction helicase activity
A4E84_RS30540	COG2235	arginine
A4E84_RS30545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4E84_RS30550	COG0531	amino acid
A4E84_RS30560	COG1024	Enoyl-CoA hydratase
A4E84_RS30570	COG1595	DNA-templated transcription, initiation
A4E84_RS30575	COG1252	NADH dehydrogenase
A4E84_RS30590	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4E84_RS30635	COG0601	transmembrane transport
A4E84_RS30640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4E84_RS30645	COG0444	Belongs to the ABC transporter superfamily
A4E84_RS30650	COG4608	Belongs to the ABC transporter superfamily
A4E84_RS30670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4E84_RS30675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4E84_RS30680	COG0019	diaminopimelate decarboxylase activity
A4E84_RS30685	COG1482	cell wall glycoprotein biosynthetic process
A4E84_RS30700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4E84_RS30720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4E84_RS30730	COG4214	carbohydrate transport
A4E84_RS30740	COG4213	ABC transporter substrate-binding protein
A4E84_RS30765	COG3458	cephalosporin-C deacetylase activity
A4E84_RS30770	COG4209	transmembrane transport
A4E84_RS30775	COG0395	ABC-type sugar transport system, permease component
A4E84_RS30800	COG1653	transport
A4E84_RS30805	COG1175	transmembrane transport
A4E84_RS30810	COG0395	ABC-type sugar transport system, permease component
A4E84_RS30815	COG1940	carbohydrate kinase activity
A4E84_RS30820	COG4213	ABC transporter substrate-binding protein
A4E84_RS30830	COG4214	carbohydrate transport
A4E84_RS30835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4E84_RS30840	COG0531	amino acid
A4E84_RS30875	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4E84_RS30875	COG1024	Enoyl-CoA hydratase
A4E84_RS30880	COG0183	Belongs to the thiolase family
A4E84_RS30885	COG1609	Transcriptional regulator
A4E84_RS30890	COG3250	beta-galactosidase activity
A4E84_RS30900	COG1175	transmembrane transport
A4E84_RS30910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4E84_RS30925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4E84_RS30935	COG0477	Major facilitator Superfamily
A4E84_RS30945	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4E84_RS30955	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4E84_RS30960	COG3253	May function as heme-dependent peroxidase
A4E84_RS30975	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS30990	COG3220	belongs to the UPF0276 family
A4E84_RS30995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4E84_RS31010	COG1116	anion transmembrane transporter activity
A4E84_RS31025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4E84_RS31025	COG0723	plastoquinol--plastocyanin reductase activity
A4E84_RS31030	COG2326	polyphosphate kinase activity
A4E84_RS31040	COG0330	HflC and HflK could
A4E84_RS31075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4E84_RS31080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4E84_RS31105	COG0745	RESPONSE REGULATOR receiver
A4E84_RS31110	COG2205	protein histidine kinase activity
A4E84_RS31120	COG1174	glycine betaine transport
A4E84_RS31125	COG1174	glycine betaine transport
A4E84_RS31165	COG0640	Transcriptional regulator
A4E84_RS31170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4E84_RS31175	COG1316	TRANSCRIPTIONal
A4E84_RS31205	COG1404	Belongs to the peptidase S8 family
A4E84_RS31210	COG1309	transcriptional regulator
A4E84_RS31260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4E84_RS31265	COG0583	DNA-binding transcription factor activity
A4E84_RS31320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4E84_RS31340	COG2409	Drug exporters of the RND superfamily
A4E84_RS31370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4E84_RS31375	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A4E84_RS31395	COG0529	Catalyzes the synthesis of activated sulfate
A4E84_RS31400	COG0175	sulfate reduction
A4E84_RS31430	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS31445	COG1917	Cupin 2, conserved barrel domain protein
A4E84_RS31445	COG4977	sequence-specific DNA binding
A4E84_RS31490	COG1175	transmembrane transport
A4E84_RS31515	COG1175	transmembrane transport
A4E84_RS31520	COG0395	ABC-type sugar transport system, permease component
A4E84_RS31550	COG2040	homocysteine
A4E84_RS31555	COG0531	amino acid
A4E84_RS31590	COG2755	lipolytic protein G-D-S-L family
A4E84_RS31615	COG1309	transcriptional regulator
A4E84_RS31650	COG1131	(ABC) transporter
A4E84_RS31660	COG0395	ABC-type sugar transport system, permease component
A4E84_RS31665	COG1175	transmembrane transport
A4E84_RS31690	COG0277	FAD linked oxidase domain protein
A4E84_RS31710	COG1162	GTPase activity
A4E84_RS31720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4E84_RS31735	COG0028	Belongs to the TPP enzyme family
A4E84_RS31765	COG1802	Transcriptional regulator
A4E84_RS31775	COG3835	regulator
A4E84_RS31790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4E84_RS31795	COG2252	PERMEase
A4E84_RS31800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4E84_RS31800	COG3608	succinylglutamate desuccinylase aspartoacylase
A4E84_RS31810	COG0726	polysaccharide deacetylase
A4E84_RS31825	COG0859	PFAM glycosyl transferase family 9
A4E84_RS31840	COG3940	Belongs to the glycosyl hydrolase 43 family
A4E84_RS31850	COG1609	Transcriptional regulator
A4E84_RS31855	COG1653	transport
A4E84_RS31870	COG0366	Alpha amylase catalytic
A4E84_RS31890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4E84_RS31895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4E84_RS31905	COG0137	argininosuccinate synthase activity
A4E84_RS31955	COG0745	RESPONSE REGULATOR receiver
A4E84_RS31960	COG5002	protein histidine kinase activity
A4E84_RS31975	COG1846	Transcriptional regulator
A4E84_RS31975	COG0456	acetyltransferase
A4E84_RS31980	COG1335	isochorismatase
A4E84_RS32025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4E84_RS32030	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS32050	COG3960	tartronate-semialdehyde synthase activity
A4E84_RS32065	COG0753	catalase activity
A4E84_RS32070	COG2084	Dehydrogenase
A4E84_RS32075	COG3622	Belongs to the hyi family
A4E84_RS32095	COG2351	hydroxyisourate hydrolase activity
A4E84_RS32110	COG2233	PERMEase
A4E84_RS32115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4E84_RS32115	COG0515	serine threonine protein kinase
A4E84_RS32125	COG3903	Transcriptional regulator
A4E84_RS32125	COG3629	intracellular signal transduction
A4E84_RS32235	COG0436	Aminotransferase
A4E84_RS32240	COG1733	regulation of RNA biosynthetic process
A4E84_RS32250	COG2304	oxidoreductase activity
A4E84_RS32255	COG4264	IucA IucC family
A4E84_RS32290	COG1120	ATPase activity
A4E84_RS32305	COG2124	cytochrome p450
A4E84_RS32335	COG0745	RESPONSE REGULATOR receiver
A4E84_RS32340	COG5002	protein histidine kinase activity
A4E84_RS32345	COG2358	TRAP transporter, solute receptor (TAXI family
A4E84_RS32365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4E84_RS32380	COG1414	Transcriptional regulator
A4E84_RS32385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4E84_RS32390	COG4266	Belongs to the allantoicase family
A4E84_RS32395	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS32420	COG2197	response regulator
A4E84_RS32425	COG0673	inositol 2-dehydrogenase activity
A4E84_RS32430	COG2188	Transcriptional regulator
A4E84_RS32435	COG1940	carbohydrate kinase activity
A4E84_RS32445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4E84_RS32475	COG2837	iron assimilation
A4E84_RS32490	COG1278	Cold shock
A4E84_RS32495	COG0513	Belongs to the DEAD box helicase family
A4E84_RS32520	COG1278	Cold shock
A4E84_RS32570	COG1316	TRANSCRIPTIONal
A4E84_RS32585	COG4326	sporulation control protein
A4E84_RS32650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A4E84_RS32665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4E84_RS32670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4E84_RS32700	COG3903	Transcriptional regulator
A4E84_RS32700	COG3629	intracellular signal transduction
A4E84_RS32735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4E84_RS32750	COG2366	antibiotic biosynthetic process
A4E84_RS32760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4E84_RS32800	COG0577	efflux transmembrane transporter activity
A4E84_RS32805	COG0577	efflux transmembrane transporter activity
A4E84_RS32805	COG1136	(ABC) transporter
A4E84_RS32810	COG4585	Histidine kinase
A4E84_RS32815	COG2197	response regulator
A4E84_RS32835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4E84_RS32850	COG0134	indole-3-glycerol-phosphate synthase activity
A4E84_RS32855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4E84_RS32865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4E84_RS32930	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS32935	COG0477	Major facilitator Superfamily
A4E84_RS32945	COG2072	flavoprotein involved in K transport
A4E84_RS32960	COG0657	acetylesterase activity
A4E84_RS32965	COG2723	6-phospho-beta-galactosidase activity
A4E84_RS32975	COG3250	beta-galactosidase activity
A4E84_RS32980	COG2211	Major facilitator Superfamily
A4E84_RS32995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4E84_RS33000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4E84_RS33020	COG1126	abc transporter atp-binding protein
A4E84_RS33025	COG2936	dipeptidyl-peptidase activity
A4E84_RS33035	COG0405	Gamma-glutamyltransferase
A4E84_RS33040	COG0542	response to heat
A4E84_RS33070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4E84_RS33085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4E84_RS33095	COG1953	Uracil, thiamine, allantoin
A4E84_RS33110	COG0483	inositol monophosphate 1-phosphatase activity
A4E84_RS33120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4E84_RS33125	COG0121	glutamine amidotransferase
A4E84_RS33155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4E84_RS33200	COG0640	Transcriptional regulator
A4E84_RS33210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4E84_RS33235	COG1929	Belongs to the glycerate kinase type-1 family
A4E84_RS33245	COG0688	phosphatidylethanolamine metabolic process
A4E84_RS33250	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS33265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS33265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4E84_RS33270	COG0604	alcohol dehydrogenase
A4E84_RS33280	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4E84_RS33300	COG2226	methyltransferase
A4E84_RS33305	COG0596	Alpha beta hydrolase
A4E84_RS33325	COG1366	Belongs to the anti-sigma-factor antagonist family
A4E84_RS33325	COG2172	sigma factor antagonist activity
A4E84_RS33325	COG2208	phosphoserine phosphatase activity
A4E84_RS33330	COG2226	methyltransferase
A4E84_RS33335	COG2755	lipolytic protein G-D-S-L family
A4E84_RS33340	COG2362	D-Aminopeptidase
A4E84_RS33345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4E84_RS33355	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4E84_RS33380	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS33390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS33405	COG3285	dna ligase
A4E84_RS33405	COG1793	dna ligase
A4E84_RS33480	COG0488	(ABC) transporter
A4E84_RS33500	COG0516	GMP reductase activity
A4E84_RS33500	COG0517	IMP dehydrogenase activity
A4E84_RS33510	COG0028	Belongs to the TPP enzyme family
A4E84_RS33580	COG0443	Heat shock 70 kDa protein
A4E84_RS33620	COG2154	pterin-4-alpha-carbinolamine dehydratase
A4E84_RS33625	COG4106	trans-aconitate 2-methyltransferase activity
A4E84_RS33625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4E84_RS33640	COG2378	regulation of single-species biofilm formation
A4E84_RS33655	COG4733	cellulase activity
A4E84_RS33655	COG5297	Belongs to the glycosyl hydrolase family 6
A4E84_RS33660	COG5297	Belongs to the glycosyl hydrolase family 6
A4E84_RS33675	COG0656	L-ascorbic acid biosynthetic process
A4E84_RS33705	COG1063	alcohol dehydrogenase
A4E84_RS33710	COG1846	Transcriptional regulator
A4E84_RS33715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4E84_RS33725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4E84_RS33730	COG3383	formate dehydrogenase (NAD+) activity
A4E84_RS33735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4E84_RS33745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4E84_RS33755	COG1940	carbohydrate kinase activity
A4E84_RS33760	COG1129	ABC transporter
A4E84_RS33765	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS33795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4E84_RS33830	COG2223	nitrite transmembrane transporter activity
A4E84_RS33840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4E84_RS33850	COG0045	succinate-CoA ligase (ADP-forming) activity
A4E84_RS33860	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS33875	COG3284	Transcriptional regulator
A4E84_RS33885	COG3485	protocatechuate 3,4-dioxygenase
A4E84_RS33890	COG1454	alcohol dehydrogenase
A4E84_RS33900	COG0702	epimerase
A4E84_RS33905	COG2353	YceI-like domain
A4E84_RS33915	COG0473	3-isopropylmalate dehydrogenase activity
A4E84_RS33925	COG2211	Major facilitator Superfamily
A4E84_RS33930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4E84_RS33935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4E84_RS33950	COG0300	oxidoreductase activity
A4E84_RS33985	COG0747	negative chemotaxis
A4E84_RS33990	COG0251	oxidation-reduction process
A4E84_RS33995	COG1733	regulation of RNA biosynthetic process
A4E84_RS34015	COG0297	glycogen (starch) synthase activity
A4E84_RS34030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4E84_RS34050	COG0477	Major facilitator Superfamily
A4E84_RS34060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4E84_RS34065	COG1082	Xylose isomerase domain protein TIM barrel
A4E84_RS34065	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A4E84_RS34075	COG0406	alpha-ribazole phosphatase activity
A4E84_RS34080	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A4E84_RS34085	COG0166	Belongs to the GPI family
A4E84_RS34100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4E84_RS34135	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS34155	COG0477	Major facilitator Superfamily
A4E84_RS34165	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS34195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4E84_RS34200	COG3250	beta-galactosidase activity
A4E84_RS34205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4E84_RS34235	COG1486	melibiose metabolic process
A4E84_RS34260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4E84_RS34290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4E84_RS34310	COG3938	Belongs to the proline racemase family
A4E84_RS34325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4E84_RS34330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4E84_RS34365	COG0577	efflux transmembrane transporter activity
A4E84_RS34365	COG1136	(ABC) transporter
A4E84_RS34370	COG4585	Histidine kinase
A4E84_RS34375	COG2197	response regulator
A4E84_RS34395	COG3511	phospholipase C
A4E84_RS34430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4E84_RS34435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4E84_RS34440	COG3485	protocatechuate 3,4-dioxygenase
A4E84_RS34445	COG3485	protocatechuate 3,4-dioxygenase
A4E84_RS34450	COG0183	Belongs to the thiolase family
A4E84_RS34465	COG1846	Transcriptional regulator
A4E84_RS34470	COG1470	cell adhesion involved in biofilm formation
A4E84_RS34480	COG1793	dna ligase
A4E84_RS34525	COG1834	amidinotransferase
A4E84_RS34535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4E84_RS34540	COG0488	(ABC) transporter
A4E84_RS34575	COG1515	deoxyribonuclease V activity
A4E84_RS34585	COG3268	Saccharopine dehydrogenase
A4E84_RS34595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4E84_RS34600	COG0183	Belongs to the thiolase family
A4E84_RS34605	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4E84_RS34605	COG1024	Enoyl-CoA hydratase
A4E84_RS34615	COG1113	amino acid transport
A4E84_RS34635	COG2936	dipeptidyl-peptidase activity
A4E84_RS34645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4E84_RS34660	COG0488	(ABC) transporter
A4E84_RS34670	COG2183	response to ionizing radiation
A4E84_RS34690	COG1024	Enoyl-CoA hydratase
A4E84_RS34700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4E84_RS34745	COG1134	teichoic acid transport
A4E84_RS34750	COG1562	ergosterol biosynthetic process
A4E84_RS34760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4E84_RS34770	COG1657	PFAM Prenyltransferase squalene oxidase
A4E84_RS34785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4E84_RS34790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4E84_RS34810	COG2365	Tyrosine phosphatase family
A4E84_RS34830	COG2755	lipolytic protein G-D-S-L family
A4E84_RS34875	COG1063	alcohol dehydrogenase
A4E84_RS34880	COG0156	8-amino-7-oxononanoate synthase activity
A4E84_RS34885	COG0583	DNA-binding transcription factor activity
A4E84_RS34895	COG0456	acetyltransferase
A4E84_RS34895	COG0454	-acetyltransferase
A4E84_RS34905	COG3958	Transketolase
A4E84_RS34910	COG3959	Transketolase, thiamine diphosphate binding domain
A4E84_RS34945	COG1396	sequence-specific DNA binding
A4E84_RS34955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4E84_RS34960	COG0022	dehydrogenase e1 component
A4E84_RS34965	COG0402	S-adenosylhomocysteine deaminase activity
A4E84_RS35000	COG0183	Belongs to the thiolase family
A4E84_RS35010	COG0647	UMP catabolic process
A4E84_RS35060	COG3511	phospholipase C
A4E84_RS35075	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A4E84_RS35075	COG2273	Hydrolase Family 16
A4E84_RS35085	COG1216	Glycosyl transferase, family 2
A4E84_RS35095	COG0463	Glycosyl transferase, family 2
A4E84_RS35105	COG3387	PFAM Glycoside hydrolase 15-related
A4E84_RS35115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4E84_RS35120	COG2188	Transcriptional regulator
A4E84_RS35130	COG3962	Belongs to the TPP enzyme family
A4E84_RS35135	COG3718	enzyme involved in inositol metabolism
A4E84_RS35145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4E84_RS35165	COG1312	Catalyzes the dehydration of D-mannonate
A4E84_RS35170	COG0673	inositol 2-dehydrogenase activity
A4E84_RS35185	COG0673	inositol 2-dehydrogenase activity
A4E84_RS35190	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS35200	COG1609	Transcriptional regulator
A4E84_RS35205	COG3548	integral membrane protein
A4E84_RS35215	COG1609	Transcriptional regulator
A4E84_RS35240	COG2197	response regulator
A4E84_RS35295	COG2838	Isocitrate dehydrogenase
A4E84_RS35305	COG0668	transmembrane transport
A4E84_RS35315	COG1132	(ABC) transporter
A4E84_RS35325	COG3290	protein histidine kinase activity
A4E84_RS35330	COG4565	transcriptional regulatory protein
A4E84_RS35345	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A4E84_RS35350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4E84_RS35355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4E84_RS35360	COG1120	ATPase activity
A4E84_RS35370	COG1132	(ABC) transporter
A4E84_RS35380	COG1132	(ABC) transporter
A4E84_RS35385	COG2382	esterase
A4E84_RS35395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4E84_RS35405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4E84_RS35425	COG3409	Peptidoglycan-binding domain 1 protein
A4E84_RS35455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4E84_RS35455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4E84_RS35475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4E84_RS35505	COG2197	response regulator
A4E84_RS35510	COG4585	Histidine kinase
A4E84_RS35515	COG1136	(ABC) transporter
A4E84_RS35535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4E84_RS35545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4E84_RS35565	COG0297	glycogen (starch) synthase activity
A4E84_RS35570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4E84_RS35600	COG0154	amidase activity
A4E84_RS35625	COG4948	Mandelate Racemase Muconate Lactonizing
A4E84_RS35630	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS35665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4E84_RS35670	COG2770	Histidine kinase
A4E84_RS35670	COG2208	phosphoserine phosphatase activity
A4E84_RS35700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4E84_RS35700	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4E84_RS35705	COG0726	polysaccharide deacetylase
A4E84_RS35760	COG1053	succinate dehydrogenase
A4E84_RS35765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4E84_RS35825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4E84_RS35840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4E84_RS35855	COG3360	Dodecin
A4E84_RS35860	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A4E84_RS35865	COG0121	glutamine amidotransferase
A4E84_RS35870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4E84_RS35925	COG1063	alcohol dehydrogenase
A4E84_RS35930	COG0402	S-adenosylhomocysteine deaminase activity
A4E84_RS35940	COG3845	ABC transporter
A4E84_RS35945	COG4603	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS35950	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS35955	COG0667	Aldo Keto reductase
A4E84_RS35975	COG3201	nicotinamide mononucleotide transporter
A4E84_RS35985	COG4213	ABC transporter substrate-binding protein
A4E84_RS35995	COG3964	amidohydrolase
A4E84_RS36015	COG0492	ferredoxin-NADP+ reductase activity
A4E84_RS36080	COG0515	serine threonine protein kinase
A4E84_RS36080	COG2815	serine threonine protein kinase
A4E84_RS36105	COG1881	PFAM PEBP family protein
A4E84_RS36110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4E84_RS36130	COG4977	sequence-specific DNA binding
A4E84_RS36150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4E84_RS36195	COG1609	Transcriptional regulator
A4E84_RS36205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4E84_RS36215	COG0242	peptide deformylase activity
A4E84_RS36245	COG1609	Transcriptional regulator
A4E84_RS36260	COG1309	transcriptional regulator
A4E84_RS36275	COG3250	beta-galactosidase activity
A4E84_RS36290	COG2755	lipolytic protein G-D-S-L family
A4E84_RS36300	COG3940	Belongs to the glycosyl hydrolase 43 family
A4E84_RS36305	COG3940	Belongs to the glycosyl hydrolase 43 family
A4E84_RS36310	COG3509	depolymerase
A4E84_RS36310	COG3693	PFAM glycoside hydrolase, family 10
A4E84_RS36325	COG0395	ABC-type sugar transport system, permease component
A4E84_RS36330	COG1175	transmembrane transport
A4E84_RS36345	COG1609	Transcriptional regulator
A4E84_RS36360	COG1131	(ABC) transporter
A4E84_RS36365	COG4585	Histidine kinase
A4E84_RS36370	COG2197	response regulator
A4E84_RS36375	COG1309	transcriptional regulator
A4E84_RS36430	COG4638	Rieske (2fe-2S)
A4E84_RS36435	COG3321	synthase
A4E84_RS36435	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS36435	COG0604	alcohol dehydrogenase
A4E84_RS36445	COG3971	2-oxopent-4-enoate hydratase activity
A4E84_RS36450	COG4569	acetaldehyde dehydrogenase (acetylating) activity
A4E84_RS36455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4E84_RS36460	COG1414	Transcriptional regulator
A4E84_RS36495	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS36505	COG2508	Transcriptional regulator
A4E84_RS36515	COG1741	Belongs to the pirin family
A4E84_RS36540	COG3268	Saccharopine dehydrogenase
A4E84_RS36555	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS36560	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS36570	COG2130	NADP-dependent
A4E84_RS36590	COG0142	geranyltranstransferase activity
A4E84_RS36615	COG1129	ABC transporter
A4E84_RS36615	COG0842	Transport permease protein
A4E84_RS36625	COG1309	transcriptional regulator
A4E84_RS36645	COG3507	Belongs to the glycosyl hydrolase 43 family
A4E84_RS36660	COG0673	inositol 2-dehydrogenase activity
A4E84_RS36665	COG1609	Transcriptional regulator
A4E84_RS36695	COG1175	transmembrane transport
A4E84_RS36700	COG0395	ABC-type sugar transport system, permease component
A4E84_RS36705	COG1115	amino acid carrier protein
A4E84_RS36705	COG1115	amino acid carrier protein
A4E84_RS36735	COG2255	four-way junction helicase activity
A4E84_RS36765	COG5285	phytanoyl-CoA dioxygenase
A4E84_RS36770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4E84_RS36775	COG0456	acetyltransferase
A4E84_RS36780	COG0038	chloride channel
A4E84_RS36790	COG0330	HflC and HflK could
A4E84_RS36865	COG3263	regulation of cellular component size
A4E84_RS36880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4E84_RS36885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4E84_RS36900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4E84_RS36915	COG0028	Belongs to the TPP enzyme family
A4E84_RS36920	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS36945	COG0028	Belongs to the TPP enzyme family
A4E84_RS36955	COG0247	lactate metabolic process
A4E84_RS36955	COG0277	FAD linked oxidase domain protein
A4E84_RS36960	COG1032	radical SAM domain protein
A4E84_RS36975	COG0726	polysaccharide deacetylase
A4E84_RS36985	COG4221	oxidoreductase activity
A4E84_RS37010	COG0671	phosphoesterase, PA-phosphatase related
A4E84_RS37025	COG0789	Transcriptional regulator
A4E84_RS37030	COG0659	secondary active sulfate transmembrane transporter activity
A4E84_RS37085	COG0477	Major facilitator Superfamily
A4E84_RS37090	COG0477	Major facilitator Superfamily
A4E84_RS37115	COG1132	(ABC) transporter
A4E84_RS37130	COG0596	Alpha beta hydrolase
A4E84_RS37145	COG1122	ATPase activity
A4E84_RS37155	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
A4E84_RS37160	COG0310	cobalt ion transport
A4E84_RS37165	COG0515	serine threonine protein kinase
A4E84_RS37165	COG2815	serine threonine protein kinase
A4E84_RS37175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4E84_RS37200	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS37240	COG0174	glutamine synthetase
A4E84_RS37255	COG4689	acetoacetate decarboxylase
A4E84_RS37275	COG1309	transcriptional regulator
A4E84_RS37285	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS37290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4E84_RS37295	COG1846	Transcriptional regulator
A4E84_RS37305	COG2197	response regulator
A4E84_RS37335	COG1121	(ABC) transporter
A4E84_RS37340	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4E84_RS37365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4E84_RS37370	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS37380	COG0542	response to heat
A4E84_RS37395	COG0577	efflux transmembrane transporter activity
A4E84_RS37395	COG1136	(ABC) transporter
A4E84_RS37400	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS37405	COG1556	Lactate utilization protein
A4E84_RS37410	COG1139	Iron-sulfur cluster binding protein
A4E84_RS37415	COG0247	lactate metabolic process
A4E84_RS37420	COG1070	Carbohydrate kinase
A4E84_RS37425	COG3347	Dehydrogenase
A4E84_RS37425	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS37435	COG1129	ABC transporter
A4E84_RS37440	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4E84_RS37465	COG1609	Transcriptional regulator
A4E84_RS37480	COG1595	DNA-templated transcription, initiation
A4E84_RS37490	COG1357	PFAM Pentapeptide repeats (8 copies)
A4E84_RS37500	COG1309	transcriptional regulator
A4E84_RS37510	COG2706	6-phosphogluconolactonase activity
A4E84_RS37575	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS37605	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS37675	COG0435	Glutathione S-transferase
A4E84_RS37695	COG2124	cytochrome p450
A4E84_RS37720	COG0667	Aldo Keto reductase
A4E84_RS37750	COG3250	beta-galactosidase activity
A4E84_RS37765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4E84_RS37810	COG2890	protein-(glutamine-N5) methyltransferase activity
A4E84_RS37825	COG0248	Ppx GppA phosphatase
A4E84_RS37875	COG0515	serine threonine protein kinase
A4E84_RS37895	COG0517	IMP dehydrogenase activity
A4E84_RS37920	COG3510	cephalosporin hydroxylase
A4E84_RS37935	COG1199	ATP-dependent helicase activity
A4E84_RS37935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4E84_RS37965	COG2130	NADP-dependent
A4E84_RS37975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4E84_RS38005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4E84_RS38030	COG1132	(ABC) transporter
A4E84_RS38045	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS38070	COG1175	transmembrane transport
A4E84_RS38075	COG1846	Transcriptional regulator
A4E84_RS38075	COG1940	carbohydrate kinase activity
A4E84_RS38095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4E84_RS38105	COG0673	inositol 2-dehydrogenase activity
A4E84_RS38115	COG1309	transcriptional regulator
A4E84_RS38170	COG1940	carbohydrate kinase activity
A4E84_RS38185	COG0395	ABC-type sugar transport system, permease component
A4E84_RS38200	COG1072	(Pantothenic acid kinase))
A4E84_RS38220	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4E84_RS38225	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A4E84_RS38265	COG0673	inositol 2-dehydrogenase activity
A4E84_RS38270	COG3973	AAA domain
A4E84_RS38275	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A4E84_RS38280	COG0667	Aldo Keto reductase
A4E84_RS38315	COG3321	synthase
A4E84_RS38315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4E84_RS38315	COG3321	synthase
A4E84_RS38315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4E84_RS38320	COG0318	PFAM AMP-dependent synthetase and ligase
A4E84_RS38325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4E84_RS38330	COG0667	Aldo Keto reductase
A4E84_RS38380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4E84_RS38385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4E84_RS38390	COG2080	2 iron, 2 sulfur cluster binding
A4E84_RS38410	COG2326	polyphosphate kinase activity
A4E84_RS38415	COG3507	Belongs to the glycosyl hydrolase 43 family
A4E84_RS38420	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS38435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4E84_RS38450	COG0583	DNA-binding transcription factor activity
A4E84_RS38455	COG0110	maltose O-acetyltransferase activity
A4E84_RS38475	COG0302	gtp cyclohydrolase
A4E84_RS38490	COG3401	FG-GAP repeat protein
A4E84_RS38495	COG2318	DinB family
A4E84_RS38520	COG1840	ABC-type Fe3 transport system, periplasmic component
A4E84_RS38535	COG4977	sequence-specific DNA binding
A4E84_RS38565	COG1966	Carbon starvation protein
A4E84_RS38615	COG0596	Alpha beta hydrolase
A4E84_RS38660	COG2723	6-phospho-beta-galactosidase activity
A4E84_RS38685	COG4608	Belongs to the ABC transporter superfamily
A4E84_RS38700	COG0601	transmembrane transport
A4E84_RS38705	COG0747	negative chemotaxis
A4E84_RS38750	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS38760	COG2353	YceI-like domain
A4E84_RS38780	COG3739	integral membrane protein
A4E84_RS38835	COG0277	FAD linked oxidase domain protein
A4E84_RS38840	COG1309	transcriptional regulator
A4E84_RS38955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4E84_RS38980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4E84_RS39005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4E84_RS39010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4E84_RS39015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4E84_RS39020	COG0438	transferase activity, transferring glycosyl groups
A4E84_RS39035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4E84_RS39045	COG3848	Pyruvate phosphate dikinase
A4E84_RS39045	COG0574	Belongs to the PEP-utilizing enzyme family
A4E84_RS39095	COG1653	transport
A4E84_RS39105	COG3833	ABC-type maltose transport systems, permease component
A4E84_RS39120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4E84_RS39125	COG1960	acyl-CoA dehydrogenase activity
A4E84_RS39135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4E84_RS39160	COG0583	DNA-binding transcription factor activity
A4E84_RS39180	COG0148	phosphopyruvate hydratase activity
A4E84_RS39220	COG1609	Transcriptional regulator
A4E84_RS39225	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4E84_RS39230	COG2814	Major facilitator Superfamily
A4E84_RS39235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4E84_RS39250	COG4552	Acetyltransferase involved in intracellular survival and related
A4E84_RS39265	COG1802	Transcriptional regulator
A4E84_RS39270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4E84_RS39280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4E84_RS39285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4E84_RS39290	COG2146	nitrite reductase [NAD(P)H] activity
A4E84_RS39300	COG4638	Rieske (2fe-2S)
A4E84_RS39315	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS39320	COG4175	Glycine betaine
A4E84_RS39320	COG0517	IMP dehydrogenase activity
A4E84_RS39325	COG4176	ABC-type proline glycine betaine transport system permease component
A4E84_RS39340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4E84_RS39345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4E84_RS39375	COG4638	Rieske (2fe-2S)
A4E84_RS39385	COG1760	l-serine dehydratase
A4E84_RS39410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4E84_RS39440	COG0277	FAD linked oxidase domain protein
A4E84_RS39445	COG1597	lipid kinase activity
A4E84_RS39460	COG1506	peptidase
A4E84_RS39460	COG0823	Involved in the tonB-independent uptake of proteins
A4E84_RS39465	COG0789	Transcriptional regulator
A4E84_RS39465	COG4978	Transcriptional regulator
A4E84_RS39490	COG0753	catalase activity
A4E84_RS39490	COG0693	protein deglycase activity
A4E84_RS39500	COG1131	(ABC) transporter
A4E84_RS39520	COG0515	serine threonine protein kinase
A4E84_RS39520	COG2815	serine threonine protein kinase
A4E84_RS39585	COG0531	amino acid
A4E84_RS39590	COG1012	belongs to the aldehyde dehydrogenase family
A4E84_RS39645	COG0494	nUDIX hydrolase
A4E84_RS39695	COG0515	serine threonine protein kinase
A4E84_RS39695	COG2815	serine threonine protein kinase
A4E84_RS39715	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4E84_RS39720	COG0702	epimerase
A4E84_RS39725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4E84_RS39735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4E84_RS39785	COG3903	Transcriptional regulator
A4E84_RS39785	COG3629	intracellular signal transduction
A4E84_RS40755	COG2835	tetraacyldisaccharide 4'-kinase activity
A4E84_RS40885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4E84_RS40890	COG0594	ribonuclease P activity
A4E84_RS41030	COG2030	dehydratase
A4E84_RS41330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4E84_RS41470	COG1028	Short-chain dehydrogenase reductase Sdr
A4E84_RS41470	COG3321	synthase
A4E84_RS41470	COG0604	alcohol dehydrogenase
A4E84_RS41685	COG2197	response regulator
A4E84_RS42040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4E84_RS42125	COG1126	abc transporter atp-binding protein
A4E84_RS42160	COG3629	intracellular signal transduction
A4E84_RS42160	COG3903	Transcriptional regulator
A4E84_RS42610	COG2267	carboxylic ester hydrolase activity
A4E84_RS42670	COG1132	(ABC) transporter