locus-tag class description FQU76_RS00005 ENOG4105MN3 Resolvase FQU76_RS00055 ENOG4105CHP RNA polymerase FQU76_RS00105 ENOG4105F0K SARP family transcriptional regulator FQU76_RS00110 ENOG4105EBM Alpha Beta Hydrolase Fold protein FQU76_RS00175 ENOG4105YVS arsR family transcriptional regulator FQU76_RS00195 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS00195 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS00225 ENOG4108KPJ rna polymerase sigma factor FQU76_RS00230 ENOG41065KQ synthase FQU76_RS00235 ENOG4108ES0 acetoacetyl-CoA synthetase FQU76_RS00245 ENOG4106SDP Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control FQU76_RS00265 ENOG4105JAB phenazine biosynthesis protein, phzf family FQU76_RS00280 ENOG4105CS1 NAD(P)H quinone oxidoreductase FQU76_RS00285 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FQU76_RS00295 ENOG41065KQ synthase FQU76_RS00320 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FQU76_RS00365 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FQU76_RS00405 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FQU76_RS00410 ENOG4105CIH Imidazole acetol-phosphate transaminase FQU76_RS00440 ENOG4105CJ1 ABC, transporter FQU76_RS00450 ENOG4105BZU Histidine kinase FQU76_RS00500 ENOG4107RNB anthranilate phosphoribosyltransferase FQU76_RS00505 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FQU76_RS00510 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FQU76_RS00515 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS00535 ENOG4107SM8 Adenylate Guanylate cyclase FQU76_RS00545 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FQU76_RS00550 ENOG4105CHR reductase FQU76_RS00575 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS00585 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS00595 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FQU76_RS00600 ENOG4107SQU synthase FQU76_RS00710 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FQU76_RS00735 ENOG4105KHM amidohydrolase 2 FQU76_RS00760 ENOG4105J76 Periplasmic binding protein FQU76_RS00765 ENOG4105DQ5 transport system permease protein FQU76_RS00770 ENOG4105TVJ transport system, permease FQU76_RS00800 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FQU76_RS00840 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein FQU76_RS00875 ENOG4105CQB FAD linked oxidase domain protein FQU76_RS00880 ENOG4105C5R Aminotransferase FQU76_RS00885 ENOG4108FUF Transcriptional regulator, IclR family FQU76_RS00915 ENOG4105CJA serine threonine protein kinase FQU76_RS00945 ENOG4105CHR reductase FQU76_RS00990 ENOG4108JJB ABC transporter FQU76_RS01000 ENOG4105GRZ Ycii-related protein FQU76_RS01010 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FQU76_RS01020 ENOG4105CRK lysyL-tRNA synthetase FQU76_RS01055 ENOG4105CC5 ABC transporter FQU76_RS01060 ENOG4105DIK (ABC) transporter FQU76_RS01065 ENOG4105X7H acyl-CoA dehydrogenase FQU76_RS01070 ENOG4105E39 Enoyl-CoA hydratase FQU76_RS01075 ENOG4105ECQ AraC Family Transcriptional Regulator FQU76_RS01095 ENOG4105C57 major facilitator superfamily FQU76_RS01105 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FQU76_RS01175 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FQU76_RS01200 ENOG4105EUJ GTP cyclohydrolase i FQU76_RS01230 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FQU76_RS01280 ENOG4105D0M Protease HtpX homolog FQU76_RS01290 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FQU76_RS01320 ENOG4105DCG PHP domain protein FQU76_RS01360 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FQU76_RS01365 ENOG4105E98 transcriptional regulator DeoR family FQU76_RS01390 ENOG4105DZC cytosine deaminase FQU76_RS01430 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FQU76_RS01440 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FQU76_RS01460 ENOG4105K64 Glycosyl transferase, family 2 FQU76_RS01470 ENOG4105EQQ protein containing aminopeptidase domain FQU76_RS01485 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FQU76_RS01495 ENOG4105CPK Glycosyl transferase (Group 1 FQU76_RS01510 ENOG4107RRD Dehydrogenase FQU76_RS01535 ENOG4105C6Y Udp-glucose 6-dehydrogenase FQU76_RS01540 ENOG4105D3Q Sugar transferase FQU76_RS01570 ENOG4105F0K SARP family transcriptional regulator FQU76_RS01635 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FQU76_RS01670 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FQU76_RS01730 ENOG4105CMT Dihydroxyacetone kinase FQU76_RS01735 ENOG4108UTZ Dihydroxyacetone kinase FQU76_RS01765 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FQU76_RS01815 ENOG4105F8D glycoside hydrolase family 4 FQU76_RS01820 ENOG4105IDI abc transporter atp-binding protein FQU76_RS01915 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FQU76_RS01920 ENOG4105CKK Glycosyl transferase, family 2 FQU76_RS01945 ENOG4105MVE transcriptional regulator FQU76_RS01980 ENOG4105DKQ ROK family FQU76_RS01995 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS02000 ENOG4105BZU Histidine kinase FQU76_RS02015 ENOG4107QZT geranylgeranyl reductase FQU76_RS02020 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FQU76_RS02035 ENOG4105I1F Resistance protein FQU76_RS02045 ENOG4108VVK transcriptional Regulator, AsnC FQU76_RS02055 ENOG4105F38 ABC transporter, permease FQU76_RS02060 ENOG4105D38 putrescine abc transporter FQU76_RS02065 ENOG4107RUE extracellular solute-binding protein family 1 FQU76_RS02070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FQU76_RS02080 ENOG4105JSC dimethylmenaquinone methyltransferase FQU76_RS02095 ENOG4107RTD sua5 ycio yrdc ywlc family protein FQU76_RS02105 ENOG41060NJ transcriptional regulator FQU76_RS02120 ENOG4105D74 hydrolase FQU76_RS02140 ENOG4105C10 Electron transfer flavoprotein FQU76_RS02150 ENOG4105PSQ Acyl-transferase FQU76_RS02165 ENOG4105C5W Aldolase FQU76_RS02180 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FQU76_RS02200 ENOG410841Q phosphoesterase PA-phosphatase related protein FQU76_RS02225 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FQU76_RS02245 ENOG4107VXZ Hydrolase FQU76_RS02270 ENOG4105D0M Protease HtpX homolog FQU76_RS02300 ENOG4105E9K Isocitrate dehydrogenase FQU76_RS02335 ENOG4105CSR polyphosphate kinase 2 FQU76_RS02350 ENOG4105DPX Hydrogenase, large subunit FQU76_RS02380 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FQU76_RS02395 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF FQU76_RS02400 ENOG4105CQS hydrogenase expression formation protein HypD FQU76_RS02415 ENOG4105CJ1 ABC, transporter FQU76_RS02440 ENOG4108UZX fmn reductase FQU76_RS02450 ENOG4105CHJ isochorismatase hydrolase FQU76_RS02475 ENOG4105BZ1 (ABC) transporter FQU76_RS02505 ENOG4105E0A ABC, transporter FQU76_RS02510 ENOG4105DQ5 transport system permease protein FQU76_RS02515 ENOG4108IHU transport system permease protein FQU76_RS02570 ENOG4105GRZ Ycii-related protein FQU76_RS02575 ENOG4105CHP RNA polymerase FQU76_RS02585 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FQU76_RS02600 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FQU76_RS02610 ENOG41065SU Two-component system sensor kinase FQU76_RS02615 ENOG4108KXV response regulator FQU76_RS02630 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS02660 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS02675 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS02685 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS02685 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS02690 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS02710 ENOG4105C5S asparaginyl-tRNA synthetase FQU76_RS02750 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase FQU76_RS02770 ENOG4107RSM transcriptional regulator FQU76_RS02775 ENOG4105DTQ mandelate racemase muconate lactonizing FQU76_RS02780 ENOG4108QMY dioxygenase FQU76_RS02800 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS02805 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FQU76_RS02810 ENOG4107W6X Transcriptional regulator FQU76_RS02855 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FQU76_RS02875 ENOG4108HHA Transketolase FQU76_RS02890 ENOG4105VEQ Cold shock protein FQU76_RS02895 ENOG4105K6V RNA polymerase FQU76_RS02900 ENOG4105RNG membrane FQU76_RS02915 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS02920 ENOG4105MKU Transcriptional regulator FQU76_RS02935 ENOG4108762 serine threonine protein kinase FQU76_RS02980 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FQU76_RS02985 ENOG4105EUB pirin domain protein FQU76_RS03080 ENOG4107ZED Uncharacterised protein family UPF0047 FQU76_RS03085 ENOG4105F95 Monooxygenase FQU76_RS03095 ENOG4105BZ1 (ABC) transporter FQU76_RS03105 ENOG4105EPC oxidoreductase FQU76_RS03110 ENOG4105BZ1 (ABC) transporter FQU76_RS03115 ENOG4105BZ1 (ABC) transporter FQU76_RS03135 ENOG4105C29 acyl-CoA thioesterase FQU76_RS03140 ENOG4108V06 Glutathione peroxidase FQU76_RS03145 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS03155 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FQU76_RS03165 ENOG4105F1K Glutamine amidotransferase FQU76_RS03170 ENOG4105CTQ phosphohexokinase FQU76_RS03190 ENOG4105F6E Acyl-transferase FQU76_RS03230 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FQU76_RS03235 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FQU76_RS03240 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FQU76_RS03270 ENOG4105C83 adenylosuccinate lyase FQU76_RS03275 ENOG4108VCA G U mismatch-specific DNA glycosylase FQU76_RS03285 ENOG4105FDP GntR family transcriptional regulator FQU76_RS03290 ENOG4108KPJ rna polymerase sigma factor FQU76_RS03315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FQU76_RS03340 ENOG4108PSK reductase FQU76_RS03355 ENOG4105EYH Exonuclease FQU76_RS03360 ENOG4107RH8 nuclease SbcCD subunit D FQU76_RS03365 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FQU76_RS03370 ENOG4105K4P CoA-binding domain protein FQU76_RS03390 ENOG4108UW5 maltose o-acetyltransferase FQU76_RS03420 ENOG4108Z0R Transferase FQU76_RS03440 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FQU76_RS03450 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FQU76_RS03460 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) FQU76_RS03470 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FQU76_RS03475 ENOG4105EP9 oxidoreductase FQU76_RS03500 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FQU76_RS03510 ENOG4105CHR reductase FQU76_RS03535 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FQU76_RS03545 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FQU76_RS03550 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FQU76_RS03615 ENOG4106P55 Transcriptional regulator FQU76_RS03625 ENOG4105CSW GntR family transcriptional regulator FQU76_RS03665 ENOG4105JAB phenazine biosynthesis protein, phzf family FQU76_RS03690 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FQU76_RS03700 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FQU76_RS03720 ENOG4108UW8 fha domain-containing protein FQU76_RS03775 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FQU76_RS03785 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FQU76_RS03795 ENOG4105E09 nadh pyrophosphatase FQU76_RS03825 ENOG4105GWZ Roadblock lc7 family protein FQU76_RS03855 ENOG4105E7W lamb ycsf family protein FQU76_RS03860 ENOG4105P4J Allophanate hydrolase, subunit 1 FQU76_RS03865 ENOG4107R7A Allophanate hydrolase subunit 2 FQU76_RS03880 ENOG4105JXB ankyrin repeat-containing protein FQU76_RS03895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FQU76_RS03915 ENOG4105Q70 FQU76_RS03925 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FQU76_RS03935 ENOG4105EW9 transcriptional regulator AsnC family FQU76_RS03950 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS04005 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FQU76_RS04010 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase FQU76_RS04015 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FQU76_RS04020 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FQU76_RS04040 ENOG4105C5I Dehydrogenase FQU76_RS04050 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FQU76_RS04055 ENOG4105E2R ROK family FQU76_RS04065 ENOG4105C2W permease FQU76_RS04075 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FQU76_RS04080 ENOG4108IND Tetr family transcriptional regulator FQU76_RS04110 ENOG4105DKT Transcriptional regulator FQU76_RS04115 ENOG4105DJV ribulose-phosphate 3-epimerase FQU76_RS04125 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FQU76_RS04135 ENOG4107RSZ Primosomal protein n' FQU76_RS04140 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FQU76_RS04165 ENOG4105SKN orotidine 5''-phosphate decarboxylase FQU76_RS04170 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FQU76_RS04175 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FQU76_RS04180 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FQU76_RS04190 ENOG4105CD3 dihydroorotase FQU76_RS04195 ENOG4105CXT aspartate transcarbamylase FQU76_RS04200 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FQU76_RS04210 ENOG410803B Involved in the transcription termination process (By similarity) FQU76_RS04215 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FQU76_RS04220 ENOG4105DC7 peptidase M24 FQU76_RS04230 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FQU76_RS04235 ENOG4105D49 3-dehydroquinate synthase FQU76_RS04240 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FQU76_RS04245 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FQU76_RS04260 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FQU76_RS04265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FQU76_RS04280 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FQU76_RS04305 ENOG4105CUT histidyl-tRNA synthetase FQU76_RS04320 ENOG4105C99 atpase involved in dna repair FQU76_RS04325 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FQU76_RS04330 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FQU76_RS04335 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FQU76_RS04340 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FQU76_RS04350 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FQU76_RS04355 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FQU76_RS04360 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FQU76_RS04365 ENOG4105CDY transcriptional regulatory protein FQU76_RS04370 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FQU76_RS04375 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FQU76_RS04385 ENOG4105E2K Glycosyl transferase (Group 1 FQU76_RS04425 ENOG4105C22 threonyL-tRNA synthetase FQU76_RS04430 ENOG4108JDX DNA polymerase iii, epsilon subunit FQU76_RS04460 ENOG4105KF0 sporulation and cell division protein, SsgA FQU76_RS04485 ENOG4105F0I Aminotransferase FQU76_RS04490 ENOG4105CRQ synthase (Component I) FQU76_RS04545 ENOG4105EEM helicase FQU76_RS04555 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FQU76_RS04560 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FQU76_RS04575 ENOG4105D01 (LipO)protein FQU76_RS04580 ENOG4108UMI ABC transporter, permease FQU76_RS04585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FQU76_RS04610 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FQU76_RS04615 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS04620 ENOG4105C57 major facilitator superfamily FQU76_RS04625 ENOG4105RJZ Transcriptional regulator FQU76_RS04635 ENOG4105CH7 arginosuccinase FQU76_RS04640 ENOG4105CDH Citrulline--aspartate ligase FQU76_RS04650 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FQU76_RS04655 ENOG4105C8Y Acetylornithine aminotransferase FQU76_RS04660 ENOG4105CAS nag kinase FQU76_RS04665 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FQU76_RS04670 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FQU76_RS04705 ENOG4105T38 integral membrane protein FQU76_RS04715 ENOG4105F32 YngK protein FQU76_RS04725 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FQU76_RS04740 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FQU76_RS04745 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FQU76_RS04750 ENOG4105BZU Histidine kinase FQU76_RS04755 ENOG4108RWN rrna methyltransferase FQU76_RS04760 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FQU76_RS04765 ENOG41084BS 50S ribosomal protein L35 FQU76_RS04770 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FQU76_RS04785 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS04805 ENOG4105C26 Dehydrogenase FQU76_RS04810 ENOG4105C5F glutamine synthetase FQU76_RS04815 ENOG41073TP transcriptional regulator FQU76_RS04820 ENOG4105C85 amino acid FQU76_RS04825 ENOG4108Z86 Glutamine amidotransferase FQU76_RS04830 ENOG4108JQ6 ABC transporter FQU76_RS04840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS04875 ENOG4108HQS Glycine betaine FQU76_RS04880 ENOG4108IJ7 Glycine betaine FQU76_RS04885 ENOG4105HFS 5'-3' exonuclease FQU76_RS04895 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FQU76_RS04905 ENOG4105CVP deoxyribo-dipyrimidine photolyase FQU76_RS04920 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FQU76_RS04925 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FQU76_RS04945 ENOG4108FFZ Transcriptional regulator FQU76_RS04955 ENOG4108V1T peptidylprolyl cis-trans isomerase FQU76_RS04960 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) FQU76_RS04980 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FQU76_RS04985 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FQU76_RS04990 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) FQU76_RS04995 ENOG4105E5F proteasome FQU76_RS05000 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FQU76_RS05030 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS05045 ENOG4105C3R Methionine synthase FQU76_RS05055 ENOG4108K8U Glycerol operon regulatory protein FQU76_RS05060 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FQU76_RS05065 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FQU76_RS05070 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FQU76_RS05075 ENOG4105JXH GntR family transcriptional regulator FQU76_RS05085 ENOG4105C8N cysteinyl-tRNA synthetase FQU76_RS05110 ENOG4105DYW oxidoreductase FQU76_RS05115 ENOG4105CPC Aldo Keto reductase FQU76_RS05150 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FQU76_RS05160 ENOG4105D3G Pseudouridine synthase FQU76_RS05180 ENOG4105C6F GntR Family Transcriptional Regulator FQU76_RS05185 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FQU76_RS05190 ENOG4105C6Z Gluconate FQU76_RS05195 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein FQU76_RS05200 ENOG4105PTV Nudix Hydrolase FQU76_RS05205 ENOG4105VG5 Membrane FQU76_RS05210 ENOG4105JP4 Inner membrane protein yidG FQU76_RS05225 ENOG4108XG4 DNA-binding transcriptional regulator FQU76_RS05230 ENOG4105EHZ conserved protein UCP016719 FQU76_RS05250 ENOG4108Z4X TRANSCRIPTIONal FQU76_RS05265 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS05275 ENOG4105D4T Citrate transporter FQU76_RS05285 ENOG4105F1J Homogentisate 1,2-dioxygenase FQU76_RS05300 ENOG4107TPY serine threonine protein kinase FQU76_RS05305 ENOG4108TCJ secreted hydrolase FQU76_RS05320 ENOG4105K64 Glycosyl transferase, family 2 FQU76_RS05325 ENOG4107BJW polysaccharide deacetylase FQU76_RS05335 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FQU76_RS05365 ENOG4106YYS transcriptional regulatory protein FQU76_RS05380 ENOG4107IFA Lipase (EC 3.1.1.3) FQU76_RS05435 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FQU76_RS05440 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS05480 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FQU76_RS05485 ENOG4105F6E Acyl-transferase FQU76_RS05490 ENOG4105CAT Cytidine monophosphate kinase FQU76_RS05500 ENOG4105KHN chorismate mutase FQU76_RS05510 ENOG410756H nucleotidyltransferase FQU76_RS05525 ENOG4105FE9 pseudouridine synthase FQU76_RS05530 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FQU76_RS05535 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FQU76_RS05550 ENOG4105DCF alanine dehydrogenase FQU76_RS05555 ENOG4105F0K SARP family transcriptional regulator FQU76_RS05560 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FQU76_RS05565 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FQU76_RS05570 ENOG4105BZP glycoside hydrolase 15-related FQU76_RS05580 ENOG4107QPH glycogen) synthase FQU76_RS05590 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FQU76_RS05600 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FQU76_RS05620 ENOG4105E0A ABC, transporter FQU76_RS05625 ENOG4105DSU hydrolase FQU76_RS05630 ENOG4105D7V transposase FQU76_RS05665 ENOG4108VX5 3-methyladenine DNA glycosylase FQU76_RS05675 ENOG4108V1U phospholipid-binding protein FQU76_RS05700 ENOG4105DKW ABC transporter FQU76_RS05720 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS05730 ENOG4105CHR reductase FQU76_RS05740 ENOG4105IDI abc transporter atp-binding protein FQU76_RS05750 ENOG4105EAC phosphoserine phosphatase FQU76_RS05765 ENOG4105DJ2 Major Facilitator Superfamily FQU76_RS05770 ENOG4107YCY Transcriptional regulator FQU76_RS05780 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FQU76_RS05785 ENOG4105CHR reductase FQU76_RS05800 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FQU76_RS05820 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FQU76_RS05825 ENOG4107QN1 sodium solute FQU76_RS05855 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FQU76_RS05870 ENOG4105BZP glycoside hydrolase 15-related FQU76_RS05875 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FQU76_RS05880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FQU76_RS05910 ENOG4105VBF alkaline shock protein FQU76_RS05920 ENOG4105E39 Enoyl-CoA hydratase FQU76_RS05930 ENOG4105C5H ABC transporter FQU76_RS05945 ENOG4107W7X Aldolase FQU76_RS05960 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FQU76_RS05965 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FQU76_RS05975 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FQU76_RS05980 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FQU76_RS06020 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FQU76_RS06090 ENOG4105C3J Cysteine desulfurase FQU76_RS06110 ENOG4105EV8 ectoine hydroxylase FQU76_RS06115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FQU76_RS06120 ENOG4108ZT1 Transcriptional regulator FQU76_RS06140 ENOG4105CJN penicillin-binding protein FQU76_RS06180 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FQU76_RS06200 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FQU76_RS06205 ENOG4108RFG Tetr family transcriptional regulator FQU76_RS06215 ENOG4105VG1 fes assembly suf system protein FQU76_RS06220 ENOG4108UNV SUF system FeS assembly protein, NifU family FQU76_RS06225 ENOG4105C9B Cysteine desulfurase FQU76_RS06230 ENOG4105C3K feS assembly ATPase SufC FQU76_RS06240 ENOG4105JRK feS assembly protein SufD FQU76_RS06275 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FQU76_RS06280 ENOG4105CV1 Transketolase (EC 2.2.1.1) FQU76_RS06285 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FQU76_RS06300 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) FQU76_RS06305 ENOG4105K7W phage-related replication protein FQU76_RS06315 ENOG4107QP8 phosphohexose isomerase FQU76_RS06330 ENOG4105CP7 Triose-phosphate isomerase FQU76_RS06335 ENOG4105BZA Phosphoglycerate kinase FQU76_RS06340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FQU76_RS06350 ENOG4105CIE May be required for sporulation (By similarity) FQU76_RS06355 ENOG4105CHW UPF0052 protein FQU76_RS06360 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FQU76_RS06365 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FQU76_RS06395 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FQU76_RS06410 ENOG4106F60 Histidine kinase FQU76_RS06415 ENOG4105F44 Two component transcriptional regulator, winged helix family FQU76_RS06430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS06435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS06455 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FQU76_RS06460 ENOG4105BZU Histidine kinase FQU76_RS06465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FQU76_RS06470 ENOG4105DXI Major Facilitator superfamily FQU76_RS06475 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FQU76_RS06480 ENOG4105D7K pfkb domain protein FQU76_RS06500 ENOG4105C0D helicase FQU76_RS06520 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FQU76_RS06530 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FQU76_RS06535 ENOG4108YRB methyltransferase FQU76_RS06540 ENOG4105CQ7 ATP-dependent helicase FQU76_RS06570 ENOG4105KA0 thioesterase Superfamily protein FQU76_RS06580 ENOG4105C32 Amino acid ABC transporter (Permease) FQU76_RS06585 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FQU76_RS06590 ENOG4105C0Z ABC transporter FQU76_RS06595 ENOG4108IV0 ABC, transporter FQU76_RS06635 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FQU76_RS06655 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FQU76_RS06680 ENOG4105EA8 2-Nitropropane dioxygenase FQU76_RS06695 ENOG4105F2C Acetyl-CoA acetyltransferase FQU76_RS06700 ENOG4108RZE Tetr family transcriptional regulator FQU76_RS06705 ENOG4105CHR reductase FQU76_RS06710 ENOG4105CC9 acyl-Coa dehydrogenase FQU76_RS06715 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS06740 ENOG4105CBC glutamate synthase FQU76_RS06750 ENOG41065RQ ADP-ribosylation crystallin J1 FQU76_RS06770 ENOG4108RVA ribokinase FQU76_RS06775 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FQU76_RS06785 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FQU76_RS06795 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FQU76_RS06800 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FQU76_RS06810 ENOG4105DK0 Indole-3-glycerol phosphate synthase FQU76_RS06830 ENOG4105CRQ synthase (Component I) FQU76_RS06835 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FQU76_RS06845 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FQU76_RS06850 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FQU76_RS06855 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FQU76_RS06860 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FQU76_RS06865 ENOG4105CIH Imidazole acetol-phosphate transaminase FQU76_RS06870 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FQU76_RS06890 ENOG4108Z66 YbaK ebsC protein FQU76_RS06915 ENOG4105C0B DNA polymerase III (alpha subunit) FQU76_RS06950 ENOG4107SUZ Sodium/hydrogen exchanger family FQU76_RS06960 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FQU76_RS06970 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FQU76_RS06975 ENOG4107VQS DivIVA family FQU76_RS06985 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FQU76_RS06990 ENOG4105DFA alanine racemase domain protein FQU76_RS06995 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FQU76_RS07000 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FQU76_RS07010 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FQU76_RS07020 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FQU76_RS07025 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FQU76_RS07035 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FQU76_RS07040 ENOG4105CJN penicillin-binding protein FQU76_RS07050 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FQU76_RS07060 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FQU76_RS07090 ENOG4105FDK ABC transporter FQU76_RS07100 ENOG4107Z3H Transcriptional regulator, TetR family FQU76_RS07105 ENOG4107VFM Dehydrogenase FQU76_RS07120 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FQU76_RS07160 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FQU76_RS07170 ENOG4108UQY Iron-storage protein FQU76_RS07180 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FQU76_RS07190 ENOG4105C5I Dehydrogenase FQU76_RS07195 ENOG4105CTQ phosphohexokinase FQU76_RS07200 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS07205 ENOG4105ENE Histidine kinase FQU76_RS07230 ENOG4105DKQ ROK family FQU76_RS07240 ENOG4105D0U Arsenite-activated ATPase (ArsA) FQU76_RS07260 ENOG4105JNK Glycosyl transferase (Group 1 FQU76_RS07310 ENOG4106F60 Histidine kinase FQU76_RS07315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS07325 ENOG4105BZW Glycerate kinase FQU76_RS07335 ENOG4108I0Q anthranilate phosphoribosyltransferase FQU76_RS07340 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FQU76_RS07345 ENOG4107EUI c reductase, iron-sulfur FQU76_RS07350 ENOG4107UDY cytochrome C FQU76_RS07355 ENOG4105CCU oxidase (Subunit III) FQU76_RS07365 ENOG4107UBC ErfK ybiS ycfS ynhG family protein FQU76_RS07370 ENOG4105MCD Part of cytochrome c oxidase, its function is FQU76_RS07375 ENOG4105BZ9 Cytochrome C oxidase, subunit I FQU76_RS07380 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FQU76_RS07390 ENOG4107T4Z adenosine kinase FQU76_RS07415 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FQU76_RS07430 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS07435 ENOG4105BZU Histidine kinase FQU76_RS07465 ENOG4105C0H protease FQU76_RS07475 ENOG4108YZT Adenosylcobinamide kinase FQU76_RS07480 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FQU76_RS07485 ENOG4105CRK lysyL-tRNA synthetase FQU76_RS07505 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FQU76_RS07525 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FQU76_RS07570 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FQU76_RS07575 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FQU76_RS07620 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FQU76_RS07630 ENOG4108222 arsenate reductase FQU76_RS07655 ENOG4107R5B glutamine synthetase FQU76_RS07660 ENOG4107NHD transcriptional regulator FQU76_RS07680 ENOG4107R13 MMPL domain protein FQU76_RS07690 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS07735 ENOG4105D56 permease protein FQU76_RS07740 ENOG4105EG2 ABC transporter, permease FQU76_RS07745 ENOG4105CG3 alpha amylase, catalytic region FQU76_RS07750 ENOG4105ETE Transcriptional regulator (LacI family FQU76_RS07760 ENOG4105C57 major facilitator superfamily FQU76_RS07785 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FQU76_RS07790 ENOG4105KJF protein tyrosine phosphatase FQU76_RS07795 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FQU76_RS07840 ENOG4105C85 amino acid FQU76_RS07865 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FQU76_RS07895 ENOG4105BZU Histidine kinase FQU76_RS07900 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS07905 ENOG4105C5F glutamine synthetase FQU76_RS07945 ENOG4107R16 Multicopper oxidase FQU76_RS07950 ENOG4105C4K Nad synthetase FQU76_RS07965 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FQU76_RS07985 ENOG4107XZ0 Peptidase M50 FQU76_RS08040 ENOG4105EWN Heme oxygenase FQU76_RS08060 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FQU76_RS08065 ENOG4105EHG Permease protein FQU76_RS08105 ENOG4105KME endoribonuclease L-psp FQU76_RS08125 ENOG4106A0S FQU76_RS08140 ENOG4105CIK Amidinotransferase FQU76_RS08150 ENOG4105C2C drug resistance transporter, Bcr CflA FQU76_RS08155 ENOG4105DGI Alkaline phosphatase FQU76_RS08180 ENOG4105GFR rna polymerase sigma factor FQU76_RS08190 ENOG4105D9P serine threonine protein kinase FQU76_RS08200 ENOG4108HMN Caspase domain FQU76_RS08245 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FQU76_RS08255 ENOG4107XFJ UPF0246 protein FQU76_RS08260 ENOG4108UHU Aldolase FQU76_RS08275 ENOG4105EGD dinuclear metal center protein, YbgI family FQU76_RS08310 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS08315 ENOG4105D2B acyl-CoA dehydrogenase FQU76_RS08335 ENOG4105DYW oxidoreductase FQU76_RS08345 ENOG4107QVI Methyltransferase, type 11 FQU76_RS08355 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FQU76_RS08360 ENOG4108SGK Tetr family transcriptional regulator FQU76_RS08400 ENOG4105BZ1 (ABC) transporter FQU76_RS08415 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FQU76_RS08420 ENOG4105F2C Acetyl-CoA acetyltransferase FQU76_RS08425 ENOG4106A3M Cytochrome p-450 FQU76_RS08450 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FQU76_RS08485 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FQU76_RS08545 ENOG4107T5V SNARE associated Golgi FQU76_RS08555 ENOG4105DAX Pfam:DUF2983 FQU76_RS08600 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FQU76_RS08605 ENOG4105EYW Ion transport protein FQU76_RS08630 ENOG4105BZU Histidine kinase FQU76_RS08635 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS08640 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FQU76_RS08710 ENOG4108FN7 Aldo keto reductase FQU76_RS08715 ENOG4105VUF Transcriptional regulator FQU76_RS08745 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FQU76_RS08765 ENOG4105NGS secreted protein FQU76_RS08785 ENOG4108ZHJ Organic hydroperoxide resistance protein FQU76_RS08790 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FQU76_RS08810 ENOG4105DFF Rod shape-determining protein mreb FQU76_RS08825 ENOG4105EW9 transcriptional regulator AsnC family FQU76_RS08840 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS08920 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FQU76_RS08925 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FQU76_RS08935 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FQU76_RS08940 ENOG4108UB4 uncharacterized protein ygjQ FQU76_RS08965 ENOG41064MX Tetr family transcriptional regulator FQU76_RS08970 ENOG4105C57 major facilitator superfamily FQU76_RS08975 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FQU76_RS08985 ENOG4105C0X amino acid FQU76_RS08995 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FQU76_RS09015 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FQU76_RS09020 ENOG4105DSE periplasmic solute binding protein FQU76_RS09025 ENOG4105FDK ABC transporter FQU76_RS09045 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FQU76_RS09050 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FQU76_RS09070 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FQU76_RS09080 ENOG4105D4Y metalloprotease FQU76_RS09090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FQU76_RS09115 ENOG4105MSB protein, conserved in bacteria FQU76_RS09125 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FQU76_RS09145 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FQU76_RS09150 ENOG4107YU2 histidine triad (hIT) protein FQU76_RS09165 ENOG4107QWG 2-Nitropropane dioxygenase FQU76_RS09170 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FQU76_RS09175 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FQU76_RS09200 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FQU76_RS09205 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FQU76_RS09220 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FQU76_RS09230 ENOG4105KQC Competence protein FQU76_RS09235 ENOG4105EPR degv family FQU76_RS09250 ENOG4105C8T Leucyl-tRNA synthetase FQU76_RS09260 ENOG4107QIZ NADH dehydrogenase FQU76_RS09290 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FQU76_RS09295 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FQU76_RS09305 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FQU76_RS09310 ENOG4105D0M Protease HtpX homolog FQU76_RS09325 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FQU76_RS09335 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FQU76_RS09350 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FQU76_RS09355 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FQU76_RS09360 ENOG4105K46 50S ribosomal protein l27 FQU76_RS09365 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FQU76_RS09370 ENOG4105J5G Transferase hexapeptide repeat containing protein FQU76_RS09385 ENOG4108IJ1 Dehydrogenase FQU76_RS09405 ENOG4105CK5 oxidoreductase FQU76_RS09410 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FQU76_RS09415 ENOG4105C03 ribonuclease FQU76_RS09440 ENOG4105CNI cell division protein FtsW FQU76_RS09460 ENOG4105DFF Rod shape-determining protein mreb FQU76_RS09465 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FQU76_RS09475 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FQU76_RS09480 ENOG4105BZU Histidine kinase FQU76_RS09485 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FQU76_RS09495 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FQU76_RS09500 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FQU76_RS09505 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FQU76_RS09510 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FQU76_RS09530 ENOG4107S91 Sodium hydrogen exchanger FQU76_RS09540 ENOG4105CHP RNA polymerase FQU76_RS09580 ENOG4105C85 amino acid FQU76_RS09585 ENOG4108JQ1 Dehydrogenase FQU76_RS09590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FQU76_RS09595 ENOG4105MC2 DSBA oxidoreductase FQU76_RS09610 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS09635 ENOG4105F27 Major Facilitator FQU76_RS09685 ENOG4108KTG Membrane protein, drug metabolite transporter FQU76_RS09690 ENOG4108ZT1 Transcriptional regulator FQU76_RS09705 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 FQU76_RS09715 ENOG4105D8X mechanosensitive ion channel FQU76_RS09735 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FQU76_RS09740 ENOG4105F8D glycoside hydrolase family 4 FQU76_RS09755 ENOG4105CT1 (ABC) transporter FQU76_RS09785 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS09825 ENOG4105VHU single-stranded DNA-binding protein FQU76_RS09830 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FQU76_RS09875 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FQU76_RS09920 ENOG4105DTT CRISPR-associated helicase, cas3 FQU76_RS09930 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) FQU76_RS09935 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) FQU76_RS09950 ENOG4105DDI hemolysin-type calcium-binding region FQU76_RS09955 ENOG4105C57 major facilitator superfamily FQU76_RS09965 ENOG4108VWQ crispr-associated protein FQU76_RS10010 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FQU76_RS10025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FQU76_RS10050 ENOG4105CHH sulfate transporter FQU76_RS10055 ENOG4107B2H carbonic anhydrase FQU76_RS10065 ENOG4106F60 Histidine kinase FQU76_RS10075 ENOG4105E8V Alpha Beta Hydrolase Fold protein FQU76_RS10105 ENOG4105C26 Dehydrogenase FQU76_RS10110 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FQU76_RS10115 ENOG4105DH8 myo-inositol catabolism FQU76_RS10125 ENOG4107UH8 sugar kinase FQU76_RS10155 ENOG4105C7H Helicase, RecD TraA family FQU76_RS10175 ENOG41060NJ transcriptional regulator FQU76_RS10180 ENOG410645S MarR family Transcriptional regulator FQU76_RS10200 ENOG4105D17 glycoside hydrolase, family 3 domain protein FQU76_RS10235 ENOG4105C7K acetolactate synthase FQU76_RS10260 ENOG4105C29 acyl-CoA thioesterase FQU76_RS10270 ENOG4108XFF FQU76_RS10280 ENOG4107QX3 carboxylase FQU76_RS10290 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FQU76_RS10295 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS10310 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FQU76_RS10320 ENOG4105DUU IucA IucC family protein FQU76_RS10325 ENOG4105E2D ec 3.2.1.52 FQU76_RS10340 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FQU76_RS10355 ENOG4105ECQ AraC Family Transcriptional Regulator FQU76_RS10360 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FQU76_RS10370 ENOG410804D Sensor Signal Transduction Histidine Kinase FQU76_RS10375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS10420 ENOG4108ZM9 phosphoglycerate mutase FQU76_RS10470 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS10520 ENOG4105BZU Histidine kinase FQU76_RS10530 ENOG4105DEN Luciferase family FQU76_RS10570 ENOG4108M1A Chitin-binding protein FQU76_RS10605 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) FQU76_RS10610 ENOG4105D9R oxidoreductase FQU76_RS10615 ENOG41090KN UPF0303 protein FQU76_RS10625 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FQU76_RS10635 ENOG4108U4N (sortase) family FQU76_RS10655 ENOG4106BRA Membrane FQU76_RS10665 ENOG4108IUW ABC transporter FQU76_RS10695 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FQU76_RS10715 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FQU76_RS10725 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FQU76_RS10745 ENOG4108RQ5 Beta-lactamase domain-containing protein FQU76_RS10755 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FQU76_RS10815 ENOG4105E0A ABC, transporter FQU76_RS10820 ENOG4105EHG Permease protein FQU76_RS10825 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FQU76_RS10835 ENOG4105C85 amino acid FQU76_RS10845 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FQU76_RS10855 ENOG4108RWI nicotinamidase FQU76_RS10890 ENOG4107TV1 YD repeat protein FQU76_RS10895 ENOG4105KF0 sporulation and cell division protein, SsgA FQU76_RS10905 ENOG4107S9F NmrA family FQU76_RS10910 ENOG4105CQB FAD linked oxidase domain protein FQU76_RS10930 ENOG4105BZU Histidine kinase FQU76_RS10935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS10940 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FQU76_RS10950 ENOG41063PX domain protein FQU76_RS10970 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS11005 ENOG4105FQP Beta-lactamase FQU76_RS11045 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FQU76_RS11060 ENOG4105E2D ec 3.2.1.52 FQU76_RS11085 ENOG4108UJU UPF0301 protein FQU76_RS11090 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FQU76_RS11095 ENOG4108426 dNA-binding protein FQU76_RS11110 ENOG4105EEM helicase FQU76_RS11110 ENOG4105EEM helicase FQU76_RS11135 ENOG4106NZI LysR family Transcriptional regulator FQU76_RS11150 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FQU76_RS11165 ENOG4105CAK Cell division ATP-binding protein ftsE FQU76_RS11185 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FQU76_RS11190 ENOG4108QVN serine threonine protein kinase FQU76_RS11195 ENOG4108UGD Serine Threonine protein kinase FQU76_RS11205 ENOG4105EPJ extracellular solute-binding protein family 1 FQU76_RS11215 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FQU76_RS11240 ENOG4105C7I Dehydrogenase FQU76_RS11245 ENOG4108Z0Z intracellular protease Pfpi family FQU76_RS11270 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FQU76_RS11280 ENOG4105T0Z Conserved Protein FQU76_RS11285 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS11290 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FQU76_RS11300 ENOG4105G3P Lipoprotein lpqB FQU76_RS11305 ENOG4105BZU Histidine kinase FQU76_RS11310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS11315 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FQU76_RS11330 ENOG4108WQ6 secreted protein FQU76_RS11335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FQU76_RS11380 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FQU76_RS11390 ENOG4105EIP mannose-6-phosphate isomerase FQU76_RS11400 ENOG4105W49 UPF0434 protein FQU76_RS11425 ENOG4107RGC Glycosyl transferase, family 2 FQU76_RS11430 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FQU76_RS11445 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) FQU76_RS11465 ENOG4108KGH TRANSCRIPTIONal FQU76_RS11470 ENOG4108KGH TRANSCRIPTIONal FQU76_RS11475 ENOG4108KGH TRANSCRIPTIONal FQU76_RS11495 ENOG4108KGH TRANSCRIPTIONal FQU76_RS11515 ENOG4105C6Y Udp-glucose 6-dehydrogenase FQU76_RS11550 ENOG41065SU Two-component system sensor kinase FQU76_RS11555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS11560 ENOG4105DUX Transporter FQU76_RS11575 ENOG4105CHR reductase FQU76_RS11600 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FQU76_RS11605 ENOG410900P UPF0336 protein FQU76_RS11615 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FQU76_RS11630 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FQU76_RS11640 ENOG4107EFR Flavocytochrome c FQU76_RS11645 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FQU76_RS11660 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS11675 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FQU76_RS11680 ENOG4105MWK D-amino acid dehydrogenase, small subunit FQU76_RS11690 ENOG4108IQE Amp-dependent synthetase and ligase FQU76_RS11730 ENOG4108JGH Tetr family transcriptional regulator FQU76_RS11750 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) FQU76_RS11755 ENOG4107XI7 Tetr family transcriptional regulator FQU76_RS11775 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FQU76_RS11930 ENOG4108SQ9 flavin reductase domain protein, FMN-binding FQU76_RS11935 ENOG4108ZHR arsR family transcriptional regulator FQU76_RS11955 ENOG4107S9F NmrA family FQU76_RS11965 ENOG4105CI2 imidazolone-5-propionate hydrolase FQU76_RS12030 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS12060 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS12065 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS12070 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FQU76_RS12075 ENOG4105CEP NADH dehydrogenase FQU76_RS12095 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FQU76_RS12110 ENOG4106A3M Cytochrome p-450 FQU76_RS12130 ENOG4105D9P serine threonine protein kinase FQU76_RS12155 ENOG4108FPN Integrase FQU76_RS12225 ENOG4108KEZ Dehydrogenase FQU76_RS12230 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FQU76_RS12245 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS12250 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS12280 ENOG4105ENE Histidine kinase FQU76_RS12290 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FQU76_RS12295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FQU76_RS12300 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FQU76_RS12305 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FQU76_RS12320 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FQU76_RS12335 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FQU76_RS12340 ENOG4108ZT1 Transcriptional regulator FQU76_RS12345 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS12350 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FQU76_RS12380 ENOG4105C5H ABC transporter FQU76_RS12395 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FQU76_RS12400 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FQU76_RS12415 ENOG4105F8V Hydrolase, tatD family FQU76_RS12440 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FQU76_RS12450 ENOG4105CJ1 ABC, transporter FQU76_RS12465 ENOG4108UV1 cellular component movement FQU76_RS12495 ENOG4108JJB ABC transporter FQU76_RS12505 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FQU76_RS12510 ENOG4105KF0 sporulation and cell division protein, SsgA FQU76_RS12515 ENOG4105EYF MMPL domain protein FQU76_RS12545 ENOG4105F95 Monooxygenase FQU76_RS12555 ENOG4105CGK Exodeoxyribonuclease III FQU76_RS12645 ENOG4105D9P serine threonine protein kinase FQU76_RS12700 ENOG4108RIR Molybdenum cofactor biosynthesis protein FQU76_RS12705 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FQU76_RS12715 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FQU76_RS12720 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FQU76_RS12725 ENOG4105CUJ penicillin amidase FQU76_RS12730 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FQU76_RS12745 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FQU76_RS12775 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FQU76_RS12780 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FQU76_RS12835 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FQU76_RS12860 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS12905 ENOG4105EC2 ftsk spoIIIe FQU76_RS12915 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FQU76_RS12925 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FQU76_RS12930 ENOG4105EM7 Selenocysteine-specific translation elongation factor FQU76_RS12935 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FQU76_RS12990 ENOG41061WM D-Alanyl-D-Alanine FQU76_RS13045 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FQU76_RS13115 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FQU76_RS13120 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FQU76_RS13270 ENOG4108ZJ4 polysaccharide deacetylase FQU76_RS13275 ENOG4105F0K SARP family transcriptional regulator FQU76_RS13315 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS13330 ENOG4105E39 Enoyl-CoA hydratase FQU76_RS13345 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FQU76_RS13375 ENOG4105D2B acyl-CoA dehydrogenase FQU76_RS13395 ENOG4105H3G oxidoreductase FQU76_RS13405 ENOG4105CGU Enoyl-CoA hydratase FQU76_RS13430 ENOG4105DCM major facilitator superfamily FQU76_RS13435 ENOG4105ECQ AraC Family Transcriptional Regulator FQU76_RS13460 ENOG4107XI7 Tetr family transcriptional regulator FQU76_RS13480 ENOG4105CC9 acyl-Coa dehydrogenase FQU76_RS13500 ENOG4105D2B acyl-CoA dehydrogenase FQU76_RS13505 ENOG4105CC9 acyl-Coa dehydrogenase FQU76_RS13510 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS13520 ENOG4105C57 major facilitator superfamily FQU76_RS13565 ENOG4107RSM transcriptional regulator FQU76_RS13570 ENOG4105NAE bifunctional deaminase-reductase domain protein FQU76_RS13600 ENOG4105EZM VWA-like domain (DUF2201) FQU76_RS13685 ENOG4108XEP Alpha Beta Hydrolase Fold protein FQU76_RS13695 ENOG4108SU4 UPF0309 protein FQU76_RS13715 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FQU76_RS13735 ENOG4107AQZ Membrane FQU76_RS13740 ENOG4106NZI LysR family Transcriptional regulator FQU76_RS13750 ENOG4105CQB FAD linked oxidase domain protein FQU76_RS13760 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FQU76_RS13790 ENOG4105CKK Glycosyl transferase, family 2 FQU76_RS13795 ENOG4105CPC Aldo Keto reductase FQU76_RS13820 ENOG4108IUZ ABC transporter FQU76_RS13840 ENOG4105C1J atp-dependent rna helicase FQU76_RS13845 ENOG4108JQ1 Dehydrogenase FQU76_RS13860 ENOG4105C7N Xanthine uracil vitamin C permease FQU76_RS13895 ENOG4108N0W Major Facilitator superfamily FQU76_RS13905 ENOG4108UIH futalosine nucleosidase FQU76_RS13910 ENOG4105E63 Pfam:DUF178 FQU76_RS13915 ENOG4105VEQ Cold shock protein FQU76_RS13950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FQU76_RS13960 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FQU76_RS13975 ENOG4105CFI type iii restriction protein res subunit FQU76_RS13985 ENOG4105EEM helicase FQU76_RS14000 ENOG4106N3A copper homeostasis protein cutc FQU76_RS14045 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FQU76_RS14050 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FQU76_RS14100 ENOG4105D7V transposase FQU76_RS14110 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FQU76_RS14140 ENOG4105C3Q Glycosyl transferase, family 2 FQU76_RS14195 ENOG4105WWF Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) FQU76_RS14230 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS14255 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS14275 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) FQU76_RS14280 ENOG4105CE4 GlcNAc 6-P deacetylase FQU76_RS14285 ENOG4105DE4 1-phosphofructokinase FQU76_RS14300 ENOG4105BZU Histidine kinase FQU76_RS14315 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FQU76_RS14350 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS14355 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FQU76_RS14385 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FQU76_RS14405 ENOG4105CJP fad dependent oxidoreductase FQU76_RS14410 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FQU76_RS14430 ENOG4107T65 Integrase FQU76_RS14440 ENOG4107ZVI PhiRv2 prophage protein FQU76_RS14510 ENOG4105GFG DUF218 domain FQU76_RS14635 ENOG4105NAF rna polymerase sigma factor FQU76_RS14645 ENOG4105BZ4 penicillin-binding protein FQU76_RS14660 ENOG4105CIS alcohol dehydrogenase FQU76_RS14670 ENOG4105C2N RNA methyltransferase TrmH family group 3 FQU76_RS14675 ENOG4105C8N cysteinyl-tRNA synthetase FQU76_RS14680 ENOG410905P Pyridoxamine 5-phosphate FQU76_RS14690 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FQU76_RS14695 ENOG4108VJ1 Transcriptional regulator (CarD family FQU76_RS14715 ENOG4105BZU Histidine kinase FQU76_RS14730 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FQU76_RS14750 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FQU76_RS14810 ENOG4105ECQ AraC Family Transcriptional Regulator FQU76_RS14815 ENOG4108UYE Lactoylglutathione lyase FQU76_RS14825 ENOG4105HHS UPF0256 protein FQU76_RS14840 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FQU76_RS14845 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FQU76_RS14850 ENOG41090R7 Ferric uptake FQU76_RS14855 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands FQU76_RS14890 ENOG4105PKJ carbohydrate binding FQU76_RS14895 ENOG4105KHC sulfurtransferase FQU76_RS14900 ENOG4105J7D transcriptional regulator FQU76_RS14925 ENOG4107NHD transcriptional regulator FQU76_RS14930 ENOG4105ETE Transcriptional regulator (LacI family FQU76_RS14945 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FQU76_RS14980 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FQU76_RS14990 ENOG4105C0H protease FQU76_RS14995 ENOG4105ETX regulatoR FQU76_RS15005 ENOG4105CGH 5'-nucleotidase FQU76_RS15025 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FQU76_RS15030 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FQU76_RS15045 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FQU76_RS15060 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FQU76_RS15070 ENOG4105CJ3 phosphate transporter FQU76_RS15080 ENOG4105VPX protein, conserved in bacteria FQU76_RS15095 ENOG4105DNP FAD linked oxidase domain protein FQU76_RS15105 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FQU76_RS15110 ENOG4105E4C Lytic transglycosylase catalytic FQU76_RS15180 ENOG4108Q50 Histidine kinase FQU76_RS15220 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS15225 ENOG4105BZU Histidine kinase FQU76_RS15260 ENOG4105D5U fad dependent oxidoreductase FQU76_RS15265 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FQU76_RS15280 ENOG4105E4C Lytic transglycosylase catalytic FQU76_RS15300 ENOG4105CHP RNA polymerase FQU76_RS15345 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FQU76_RS15350 ENOG4107S9R deoxycytidine triphosphate deaminase FQU76_RS15365 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FQU76_RS15370 ENOG4105BZU Histidine kinase FQU76_RS15400 ENOG4108KQ5 Integrase catalytic subunit FQU76_RS15420 ENOG4105C1J atp-dependent rna helicase FQU76_RS15430 ENOG41083TI Protein CrcB homolog FQU76_RS15435 ENOG41083YR Protein CrcB homolog FQU76_RS15470 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FQU76_RS15480 ENOG4105CQ7 ATP-dependent helicase FQU76_RS15495 ENOG4108TAC FQU76_RS15510 ENOG4105CXB phosphoribosylaminoimidazole synthetase FQU76_RS15530 ENOG4105E4C Lytic transglycosylase catalytic FQU76_RS15540 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FQU76_RS15545 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FQU76_RS15550 ENOG410839H phosphoribosylformylglycinamidine synthase FQU76_RS15570 ENOG4105CJ1 ABC, transporter FQU76_RS15580 ENOG4105BZU Histidine kinase FQU76_RS15595 ENOG4105C8V SAICAR synthetase FQU76_RS15610 ENOG4105C12 Phosphoribosylglycinamide synthetase FQU76_RS15665 ENOG4105C9B Cysteine desulfurase FQU76_RS15690 ENOG4105NX3 Membrane FQU76_RS15720 ENOG4105WZW rhodanese family FQU76_RS15725 ENOG4105VPX protein, conserved in bacteria FQU76_RS15775 ENOG4105IIU Aminopeptidase FQU76_RS15780 ENOG4105D7A ATP-binding protein FQU76_RS15795 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FQU76_RS15810 ENOG4108Z6B deaminase FQU76_RS15840 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein FQU76_RS15845 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FQU76_RS15850 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FQU76_RS15865 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FQU76_RS15880 ENOG4105C57 major facilitator superfamily FQU76_RS15885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS15940 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS15970 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS15975 ENOG4105NAF rna polymerase sigma factor FQU76_RS16015 ENOG4105C0H protease FQU76_RS16055 ENOG4107T6F Xaa-Pro aminopeptidase FQU76_RS16090 ENOG4105JDN Copper resistance protein FQU76_RS16095 ENOG4105DBE peroxidase FQU76_RS16105 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FQU76_RS16110 ENOG410667J hydrolase FQU76_RS16140 ENOG4108XDN Transcriptional regulator FQU76_RS16145 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) FQU76_RS16160 ENOG4108K4B hydrolase FQU76_RS16165 ENOG4105E4C Lytic transglycosylase catalytic FQU76_RS16175 ENOG4108JJ9 ABC, transporter FQU76_RS16180 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FQU76_RS16185 ENOG4105C4M (Ubiquinol oxidase) subunit I FQU76_RS16190 ENOG4105CIH Imidazole acetol-phosphate transaminase FQU76_RS16195 ENOG4107P2S Transcriptional regulator FQU76_RS16210 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FQU76_RS16245 ENOG4106048 Cupin 2, conserved barrel domain protein FQU76_RS16250 ENOG4105C28 cystathionine FQU76_RS16290 ENOG4105CDU Replicative dna helicase FQU76_RS16300 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FQU76_RS16305 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FQU76_RS16310 ENOG4107YH6 single-stranded DNA-binding protein FQU76_RS16315 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) FQU76_RS16340 ENOG4105BZ4 penicillin-binding protein FQU76_RS16350 ENOG4105CZA synthase FQU76_RS16360 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FQU76_RS16375 ENOG4105D9P serine threonine protein kinase FQU76_RS16390 ENOG4105C3M thioredoxin reductase FQU76_RS16395 ENOG4105K63 Thioredoxin FQU76_RS16410 ENOG4107QJE Chromosome Partitioning Protein FQU76_RS16415 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FQU76_RS16425 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FQU76_RS16430 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FQU76_RS16435 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FQU76_RS16440 ENOG41084CH 50S ribosomal protein l34 FQU76_RS16455 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FQU76_RS16460 ENOG4108J5G 6-phosphogluconate dehydrogenase FQU76_RS16465 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FQU76_RS16470 ENOG4105K7N UPF0232 protein FQU76_RS16480 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FQU76_RS16510 ENOG4108UGD Serine Threonine protein kinase FQU76_RS16530 ENOG4108KPJ rna polymerase sigma factor FQU76_RS16555 ENOG4105ZJT Cell division protein CrgA FQU76_RS16565 ENOG4108U4N (sortase) family FQU76_RS16580 ENOG4108U4N (sortase) family FQU76_RS16585 ENOG4108RN7 integral membrane protein FQU76_RS16595 ENOG4105CJN penicillin-binding protein FQU76_RS16600 ENOG4107QHZ cell cycle protein FQU76_RS16610 ENOG4105HZM Fha domain containing protein FQU76_RS16615 ENOG4105TV9 FHA Domain-Containing protein FQU76_RS16625 ENOG4105ENE Histidine kinase FQU76_RS16630 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS16645 ENOG41082J7 Rhodanese domain protein FQU76_RS16655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FQU76_RS16660 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FQU76_RS16665 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FQU76_RS16670 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FQU76_RS16675 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FQU76_RS16720 ENOG4107QSN dihydrolipoamide acetyltransferase FQU76_RS16725 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FQU76_RS16795 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FQU76_RS16810 ENOG4107QPV Serine Threonine protein kinase FQU76_RS16840 ENOG4105CPP Dehydrogenase, E1 component FQU76_RS16845 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FQU76_RS16880 ENOG4105DFM M18 family aminopeptidase FQU76_RS16895 ENOG4105CSU acyl-Coa dehydrogenase FQU76_RS16905 ENOG4105EUB pirin domain protein FQU76_RS16915 ENOG4108VQR secreted hydrolase FQU76_RS16920 ENOG4105C9M aspartyl-trna synthetase FQU76_RS16995 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FQU76_RS17025 ENOG4108X7A Terpene synthase metal-binding domain-containing protein FQU76_RS17030 ENOG41068W2 Cytochrome p-450 FQU76_RS17060 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FQU76_RS17130 ENOG4107SM8 Adenylate Guanylate cyclase FQU76_RS17140 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FQU76_RS17160 ENOG4105D7N magnesium and cobalt transport protein CorA FQU76_RS17170 ENOG4105EB3 Histidine kinase FQU76_RS17210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FQU76_RS17285 ENOG4105S6R Iron-hydroxamate transporter permease subunit FQU76_RS17290 ENOG4105J76 Periplasmic binding protein FQU76_RS17335 ENOG4105EYF MMPL domain protein FQU76_RS17365 ENOG4105C10 Electron transfer flavoprotein FQU76_RS17460 ENOG4105C57 major facilitator superfamily FQU76_RS17465 ENOG4105DUU IucA IucC family protein FQU76_RS17480 ENOG4105C85 amino acid FQU76_RS17500 ENOG4105DXX methyltransferase FQU76_RS17515 ENOG4105CF7 AraC family transcriptional regulator FQU76_RS17520 ENOG4105CPC Aldo Keto reductase FQU76_RS17570 ENOG4105FDP GntR family transcriptional regulator FQU76_RS17580 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS17605 ENOG4105DHP deoxycytidine triphosphate deaminase FQU76_RS17620 ENOG4105DF6 Fe-S oxidoreductase FQU76_RS17625 ENOG4105D3Q Sugar transferase FQU76_RS17630 ENOG4105CFG Acts as a chaperone (By similarity) FQU76_RS17635 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FQU76_RS17640 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FQU76_RS17645 ENOG4105KNI merR family transcriptional Regulator FQU76_RS17665 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FQU76_RS17705 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FQU76_RS17720 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FQU76_RS17725 ENOG4107RCW fructose-bisphosphate aldolase FQU76_RS17750 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS17765 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FQU76_RS17785 ENOG410905P Pyridoxamine 5-phosphate FQU76_RS17790 ENOG4106A3M Cytochrome p-450 FQU76_RS17795 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS17800 ENOG4105BZU Histidine kinase FQU76_RS17810 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FQU76_RS17825 ENOG4105BZ1 (ABC) transporter FQU76_RS17850 ENOG4108JPW Aminotransferase FQU76_RS17855 ENOG4108V4B ThiJ pfpI FQU76_RS17870 ENOG4108762 serine threonine protein kinase FQU76_RS17925 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FQU76_RS17960 ENOG4105DRR Transcriptional regulator, GntR family FQU76_RS17970 ENOG4105CKK Glycosyl transferase, family 2 FQU76_RS17985 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FQU76_RS17990 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FQU76_RS18000 ENOG4105CFH Aspartokinase FQU76_RS18010 ENOG4105NAF rna polymerase sigma factor FQU76_RS18035 ENOG4105DR4 Methyltransferase FQU76_RS18190 ENOG4105CMD Transcriptional regulator, GntR family FQU76_RS18220 ENOG4105KTH gatB Yqey FQU76_RS18225 ENOG4105BZ4 penicillin-binding protein FQU76_RS18265 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FQU76_RS18295 ENOG4105D74 hydrolase FQU76_RS18305 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FQU76_RS18310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FQU76_RS18315 ENOG4107B2H carbonic anhydrase FQU76_RS18375 ENOG4108I5C dEAD DEAH box helicase FQU76_RS18380 ENOG4105WN5 stage II sporulation protein FQU76_RS18385 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FQU76_RS18390 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for FQU76_RS18400 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FQU76_RS18410 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FQU76_RS18415 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FQU76_RS18420 ENOG4105C6E dna polymerase iii FQU76_RS18425 ENOG4106JDR secreted FQU76_RS18460 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FQU76_RS18465 ENOG4108UCS ABC, transporter FQU76_RS18510 ENOG4105CPF Cell wall formation (By similarity) FQU76_RS18565 ENOG4105CPF Cell wall formation (By similarity) FQU76_RS18570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FQU76_RS18700 ENOG4105CDU Replicative dna helicase FQU76_RS18770 ENOG4107SN7 NLP P60 protein FQU76_RS18830 ENOG41082YX Transcriptional regulator, arsr family FQU76_RS18880 ENOG4105DEN Luciferase family FQU76_RS18885 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FQU76_RS18905 ENOG4105C0X amino acid FQU76_RS18910 ENOG4108Q50 Histidine kinase FQU76_RS18960 ENOG4108Z4K mutator MutT protein FQU76_RS18990 ENOG4105GFG DUF218 domain FQU76_RS18995 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS19010 ENOG4106NZI LysR family Transcriptional regulator FQU76_RS19050 ENOG4105C0B DNA polymerase III (alpha subunit) FQU76_RS19115 ENOG4105BZ1 (ABC) transporter FQU76_RS19155 ENOG4105ECQ AraC Family Transcriptional Regulator FQU76_RS19165 ENOG4105C2M dna polymerase I FQU76_RS19180 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FQU76_RS19195 ENOG4105EV4 Multidrug resistance protein mdtH FQU76_RS19215 ENOG4105D3W isochorismatase FQU76_RS19255 ENOG4105C26 Dehydrogenase FQU76_RS19280 ENOG4105CVK Glutamate decarboxylase FQU76_RS19285 ENOG41082VC UPF0145 protein FQU76_RS19290 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN FQU76_RS19300 ENOG4105F0N pyrophosphate phospho-hydrolase FQU76_RS19315 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FQU76_RS19320 ENOG4108UGV hypoxanthine phosphoribosyltransferase FQU76_RS19330 ENOG4105EUJ GTP cyclohydrolase i FQU76_RS19375 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FQU76_RS19430 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FQU76_RS19450 ENOG4105CRK lysyL-tRNA synthetase FQU76_RS19460 ENOG4108IJ8 ABC transporter FQU76_RS19465 ENOG4105E90 ABC transporter FQU76_RS19470 ENOG4105E90 ABC transporter FQU76_RS19485 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS19500 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS19505 ENOG4105I1F Resistance protein FQU76_RS19510 ENOG41082SX arsR family transcriptional regulator FQU76_RS19530 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FQU76_RS19535 ENOG4108IYU L-aspartate oxidase FQU76_RS19545 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FQU76_RS19590 ENOG4105DR5 peptidase FQU76_RS19595 ENOG4108FKE two-component system sensor kinase FQU76_RS19600 ENOG4108PYU two-component system response regulator FQU76_RS19605 ENOG41075QH Lipoprotein CseA FQU76_RS19610 ENOG4105NAF rna polymerase sigma factor FQU76_RS19615 ENOG4105CEN a g-specific adenine glycosylase FQU76_RS19620 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FQU76_RS19630 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FQU76_RS19645 ENOG4108JWX FQU76_RS19650 ENOG4107R33 ppx gppa phosphatase FQU76_RS19655 ENOG4105EY0 Xylose isomerase domain protein TIM barrel FQU76_RS19665 ENOG4105C01 Dihydroxy-acid dehydratase FQU76_RS19685 ENOG4108KPJ rna polymerase sigma factor FQU76_RS19695 ENOG4105CJ1 ABC, transporter FQU76_RS19705 ENOG4105II7 pyrroline-5-carboxylate reductase FQU76_RS19710 ENOG4105C31 Tryptophanyl-tRNA synthetase FQU76_RS19740 ENOG4105DGU Histone deacetylase FQU76_RS19790 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FQU76_RS19795 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FQU76_RS19800 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FQU76_RS19805 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FQU76_RS19825 ENOG4105D52 delta-aminolevulinic acid dehydratase FQU76_RS19835 ENOG4105C5F glutamine synthetase FQU76_RS19865 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FQU76_RS19890 ENOG4105C75 arginyL-tRNA synthetase FQU76_RS19895 ENOG4105DK7 lysyl-tRNA synthetase FQU76_RS19900 ENOG41080QX K07048 phosphotriesterase-related protein FQU76_RS19905 ENOG4106M0N transport system permease protein FQU76_RS19955 ENOG4105E0Y RtcB Protein FQU76_RS19965 ENOG4105KK4 UPF0060 membrane protein FQU76_RS20005 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FQU76_RS20010 ENOG4108RH7 phosphoglycerate mutase FQU76_RS20030 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) FQU76_RS20045 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FQU76_RS20050 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FQU76_RS20060 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FQU76_RS20070 ENOG4105DVY radical SAM domain protein FQU76_RS20085 ENOG4107QJT sodium dicarboxylate symporter FQU76_RS20090 ENOG4108R86 Transcriptional regulator FQU76_RS20105 ENOG4105VEQ Cold shock protein FQU76_RS20110 ENOG4105EV6 Pfam:DUF178 FQU76_RS20115 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FQU76_RS20125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FQU76_RS20160 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FQU76_RS20165 ENOG4108R85 Short chain dehydrogenase FQU76_RS20180 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20185 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FQU76_RS20190 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20200 ENOG4107QIZ NADH dehydrogenase FQU76_RS20205 ENOG4108IEH NADH dehydrogenase subunit g FQU76_RS20210 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FQU76_RS20215 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20220 ENOG41087XN oxidoreductase FQU76_RS20225 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20230 ENOG4105D65 subunit l FQU76_RS20240 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20250 ENOG4105ERH Fumarylacetoacetate hydrolase FQU76_RS20285 ENOG4105IIU Aminopeptidase FQU76_RS20335 ENOG4105DQU oxidoreductase, subunit beta FQU76_RS20340 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FQU76_RS20360 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FQU76_RS20365 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20370 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FQU76_RS20375 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FQU76_RS20380 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20385 ENOG4107YX3 NADH dehydrogenase subunit j FQU76_RS20390 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20395 ENOG4105D65 subunit l FQU76_RS20400 ENOG4105C8S subunit m FQU76_RS20405 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FQU76_RS20410 ENOG4105D0M Protease HtpX homolog FQU76_RS20415 ENOG410901E Membrane FQU76_RS20430 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FQU76_RS20435 ENOG4108VPT UPF0234 protein FQU76_RS20470 ENOG4105WDJ 50S ribosomal protein L33 FQU76_RS20475 ENOG410900P UPF0336 protein FQU76_RS20495 ENOG4107R4N Cell wall formation (By similarity) FQU76_RS20520 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FQU76_RS20525 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FQU76_RS20530 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FQU76_RS20540 ENOG4108VZM 50s ribosomal protein L10 FQU76_RS20545 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FQU76_RS20555 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FQU76_RS20560 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FQU76_RS20660 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FQU76_RS20665 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FQU76_RS20670 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FQU76_RS20675 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FQU76_RS20700 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FQU76_RS20705 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FQU76_RS20710 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FQU76_RS20715 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FQU76_RS20720 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FQU76_RS20725 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FQU76_RS20730 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FQU76_RS20735 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FQU76_RS20740 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FQU76_RS20745 ENOG41082SA 50s ribosomal protein l29 FQU76_RS20750 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FQU76_RS20755 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FQU76_RS20760 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FQU76_RS20765 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FQU76_RS20770 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FQU76_RS20780 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FQU76_RS20785 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FQU76_RS20790 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FQU76_RS20795 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FQU76_RS20800 ENOG410849U 50S ribosomal protein L30 FQU76_RS20805 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FQU76_RS20810 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FQU76_RS20815 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FQU76_RS20825 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FQU76_RS20835 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FQU76_RS20840 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FQU76_RS20845 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FQU76_RS20850 ENOG4108ZT0 50S ribosomal protein l17 FQU76_RS20855 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FQU76_RS20865 ENOG4105C5H ABC transporter FQU76_RS20870 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FQU76_RS20875 ENOG4108UJD 30S ribosomal protein S9 FQU76_RS20880 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FQU76_RS20895 ENOG4105YVS arsR family transcriptional regulator FQU76_RS20910 ENOG4105CS9 pantothenic acid kinase FQU76_RS20915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FQU76_RS20940 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FQU76_RS20945 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FQU76_RS20950 ENOG4108097 ATP-binding protein FQU76_RS20975 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FQU76_RS20990 ENOG4105CHP RNA polymerase FQU76_RS21020 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FQU76_RS21025 ENOG4108JQ1 Dehydrogenase FQU76_RS21030 ENOG4105EMU Dehydrogenase FQU76_RS21040 ENOG4105DND Transcriptional regulator FQU76_RS21045 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FQU76_RS21050 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS21055 ENOG4108MMM RNA Polymerase FQU76_RS21065 ENOG4107QVP Dehydrogenase FQU76_RS21075 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FQU76_RS21095 ENOG4105C26 Dehydrogenase FQU76_RS21115 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FQU76_RS21120 ENOG4105F9F transposase FQU76_RS21150 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS21170 ENOG4105DR5 peptidase FQU76_RS21195 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FQU76_RS21200 ENOG4105RD5 FQU76_RS21205 ENOG4105DEG Vwa containing coxe family protein FQU76_RS21210 ENOG4105CMV Succinyl-CoA synthetase subunit beta FQU76_RS21240 ENOG4105DC1 bifunctional purine biosynthesis protein purh FQU76_RS21250 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FQU76_RS21265 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FQU76_RS21270 ENOG4105EMU Dehydrogenase FQU76_RS21280 ENOG4105C8Y Acetylornithine aminotransferase FQU76_RS21285 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FQU76_RS21300 ENOG4105EMN RNA polymerase sigma factor FQU76_RS21305 ENOG4105C31 Tryptophanyl-tRNA synthetase FQU76_RS21350 ENOG4107RN3 metallophosphoesterase FQU76_RS21355 ENOG4105BZU Histidine kinase FQU76_RS21360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS21365 ENOG4105EYF MMPL domain protein FQU76_RS21400 ENOG4108J01 L-aspartate oxidase FQU76_RS21420 ENOG4105E2D ec 3.2.1.52 FQU76_RS21440 ENOG4108MMM RNA Polymerase FQU76_RS21460 ENOG4108NIW Leucine export protein LeuE FQU76_RS21480 ENOG4107RM1 amidohydrolase FQU76_RS21485 ENOG4105DIH basic membrane FQU76_RS21490 ENOG4108JQ9 ABC transporter FQU76_RS21495 ENOG4105UIB (ABC) transporter FQU76_RS21530 ENOG4105D94 Major Facilitator Superfamily FQU76_RS21535 ENOG4107RSM transcriptional regulator FQU76_RS21550 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FQU76_RS21575 ENOG41065SU Two-component system sensor kinase FQU76_RS21580 ENOG4108KXV response regulator FQU76_RS21585 ENOG4105NAF rna polymerase sigma factor FQU76_RS21590 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FQU76_RS21595 ENOG4105C26 Dehydrogenase FQU76_RS21600 ENOG4105C26 Dehydrogenase FQU76_RS21620 ENOG4105F9F transposase FQU76_RS21665 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain FQU76_RS21685 ENOG4105E98 transcriptional regulator DeoR family FQU76_RS21695 ENOG4108JIK carboxylase FQU76_RS21700 ENOG4107WR6 Maf-like protein FQU76_RS21710 ENOG4105D8K carboxyl transferase FQU76_RS21720 ENOG4108QER Adenylate cyclase FQU76_RS21725 ENOG4105E39 Enoyl-CoA hydratase FQU76_RS21730 ENOG4105KDM Diguanylate cyclase with gaf sensor FQU76_RS21735 ENOG4105C84 Histidine ammonia-lyase FQU76_RS21745 ENOG4107UBC ErfK ybiS ycfS ynhG family protein FQU76_RS21790 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FQU76_RS21815 ENOG4105NAF rna polymerase sigma factor FQU76_RS21825 ENOG4105C7B Threonine dehydratase FQU76_RS21840 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FQU76_RS21850 ENOG4105T1M mycothiol conjugate amidase mca FQU76_RS21900 ENOG4105C7Z Conserved Protein FQU76_RS21935 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FQU76_RS22000 ENOG4105D3Q Sugar transferase FQU76_RS22010 ENOG4105CJR Integral membrane protein (MviN FQU76_RS22115 ENOG4108FUF Transcriptional regulator, IclR family FQU76_RS22120 ENOG4105KME endoribonuclease L-psp FQU76_RS22125 ENOG4105C6Z Gluconate FQU76_RS22135 ENOG4105YVS arsR family transcriptional regulator FQU76_RS22190 ENOG4105EQK -acetyltransferase FQU76_RS22230 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FQU76_RS22270 ENOG4106A3M Cytochrome p-450 FQU76_RS22295 ENOG4105DHQ Histidine kinase FQU76_RS22370 ENOG4107QKZ Ompa motb domain protein FQU76_RS22395 ENOG4105KVH Transcriptional regulator FQU76_RS22400 ENOG4105CPC Aldo Keto reductase FQU76_RS22405 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FQU76_RS22410 ENOG4108IAB Phoh family FQU76_RS22430 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FQU76_RS22435 ENOG4105D3R alkyl hydroperoxide reductase FQU76_RS22445 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FQU76_RS22460 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FQU76_RS22475 ENOG4105BZ4 penicillin-binding protein FQU76_RS22480 ENOG4105CH6 catalase FQU76_RS22495 ENOG4105C9Q fumarate hydratase class II FQU76_RS22505 ENOG4107GFK fumarate FQU76_RS22530 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FQU76_RS22540 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FQU76_RS22545 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FQU76_RS22555 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FQU76_RS22570 ENOG4105C3G gtp-binding protein FQU76_RS22630 ENOG41087YS Phage shock protein A FQU76_RS22645 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FQU76_RS22665 ENOG4105CI3 gtp-binding protein typa FQU76_RS22670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS22675 ENOG4108J59 Extracellular solute-binding protein, family 5 FQU76_RS22685 ENOG4105C3U ABC transporter FQU76_RS22690 ENOG4108JQ7 (ABC) transporter FQU76_RS22705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FQU76_RS22710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS22715 ENOG4105C3U ABC transporter FQU76_RS22720 ENOG4108JQ7 (ABC) transporter FQU76_RS22735 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FQU76_RS22750 ENOG4105F9F transposase FQU76_RS22765 ENOG4108Z4U Ferredoxin FQU76_RS22790 ENOG4107R4C succinyl-diaminopimelate desuccinylase FQU76_RS22795 ENOG4108URH decarboxylase FQU76_RS22800 ENOG4105EEI dihydropteroate synthase FQU76_RS22810 ENOG4108R3E Dna-3-methyladenine glycosylase i FQU76_RS22815 ENOG4108UKI Enoyl-CoA hydratase FQU76_RS22835 ENOG4105DU6 RNA polymerase FQU76_RS22845 ENOG4105C0H protease FQU76_RS22850 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FQU76_RS22885 ENOG4105D7N magnesium and cobalt transport protein CorA FQU76_RS22910 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FQU76_RS22915 ENOG4106HB6 Alpha beta hydrolase FQU76_RS22920 ENOG4105C1J atp-dependent rna helicase FQU76_RS23020 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FQU76_RS23045 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FQU76_RS23110 ENOG41063PX domain protein FQU76_RS23120 ENOG4105DJZ UPF0182 protein FQU76_RS23160 ENOG4107TK4 histidinol-phosphate phosphatase FQU76_RS23165 ENOG4105KPY Small multidrug resistance protein FQU76_RS23170 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FQU76_RS23175 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FQU76_RS23185 ENOG4108RAV Conserved protein FQU76_RS23195 ENOG4105EMN RNA polymerase sigma factor FQU76_RS23200 ENOG4105WMN AntiSigma factor FQU76_RS23205 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FQU76_RS23220 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FQU76_RS23225 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FQU76_RS23230 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FQU76_RS23235 ENOG4105FDP GntR family transcriptional regulator FQU76_RS23255 ENOG4105D17 glycoside hydrolase, family 3 domain protein FQU76_RS23260 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FQU76_RS23275 ENOG4105CBD Diacylglycerol kinase FQU76_RS23330 ENOG4108KXM LysR family Transcriptional regulator FQU76_RS23340 ENOG4108YZ4 nudix hydrolase FQU76_RS23345 ENOG4108VEQ Superoxide dismutase FQU76_RS23360 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FQU76_RS23365 ENOG4105NAF rna polymerase sigma factor FQU76_RS23380 ENOG4105E5Q amino acid AbC transporter FQU76_RS23385 ENOG4107RP9 extracellular solute-binding protein, family 3 FQU76_RS23400 ENOG4105CB2 alcohol dehydrogenase FQU76_RS23445 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FQU76_RS23455 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FQU76_RS23465 ENOG4105EB3 Histidine kinase FQU76_RS23470 ENOG4108PYU two-component system response regulator FQU76_RS23490 ENOG4105CJ1 ABC, transporter FQU76_RS23510 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FQU76_RS23515 ENOG4105DDN Pentapeptide repeat-containing protein FQU76_RS23535 ENOG4105BZU Histidine kinase FQU76_RS23585 ENOG4105CJN penicillin-binding protein FQU76_RS23595 ENOG4108FKE two-component system sensor kinase FQU76_RS23620 ENOG4105DQE DNA ligase FQU76_RS23625 ENOG4105DQE DNA ligase FQU76_RS23630 ENOG4105FDF Could be involved in DNA repair (By similarity) FQU76_RS23635 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS23665 ENOG4105DRR Transcriptional regulator, GntR family FQU76_RS23725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS23730 ENOG4105C75 arginyL-tRNA synthetase FQU76_RS23735 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FQU76_RS23740 ENOG4105D6E homoserine dehydrogenase FQU76_RS23745 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FQU76_RS23750 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FQU76_RS23760 ENOG4108KGH TRANSCRIPTIONal FQU76_RS23765 ENOG4105VFB Binds the 23S rRNA (By similarity) FQU76_RS23770 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FQU76_RS23775 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FQU76_RS23785 ENOG4107ZF2 Phosphatase FQU76_RS23790 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FQU76_RS23800 ENOG4105Z3P ATP synthase FQU76_RS23810 ENOG4105ZA1 atp synthase FQU76_RS23815 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FQU76_RS23820 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FQU76_RS23825 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FQU76_RS23830 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FQU76_RS23835 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FQU76_RS23840 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FQU76_RS23855 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS23860 ENOG4105BZU Histidine kinase FQU76_RS23875 ENOG410630P Transcriptional regulator FQU76_RS23880 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FQU76_RS23895 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) FQU76_RS23920 ENOG4105CJ1 ABC, transporter FQU76_RS23950 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS23965 ENOG4105ETX regulatoR FQU76_RS23970 ENOG4106F60 Histidine kinase FQU76_RS24005 ENOG4105WX6 Membrane FQU76_RS24045 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FQU76_RS24050 ENOG4105C6K Malic enzyme FQU76_RS24055 ENOG4105CTQ phosphohexokinase FQU76_RS24070 ENOG4108MRH transcriptional regulatory protein FQU76_RS24075 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FQU76_RS24080 ENOG4107QJT sodium dicarboxylate symporter FQU76_RS24110 ENOG4108JU3 Alkyl hydroperoxide reductase FQU76_RS24135 ENOG4105CG3 alpha amylase, catalytic region FQU76_RS24140 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FQU76_RS24155 ENOG4105EFA 4-hydroxyphenylacetate FQU76_RS24165 ENOG41061H0 Monooxygenase FQU76_RS24225 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FQU76_RS24230 ENOG4106F60 Histidine kinase FQU76_RS24235 ENOG4105F44 Two component transcriptional regulator, winged helix family FQU76_RS24240 ENOG4107WD8 ABC transporter, permease FQU76_RS24305 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein FQU76_RS24335 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS24355 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FQU76_RS24385 ENOG4105EJQ L-serine dehydratase FQU76_RS24390 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FQU76_RS24395 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FQU76_RS24400 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FQU76_RS24420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS24440 ENOG4108JQ7 (ABC) transporter FQU76_RS24445 ENOG4105EN6 Membrane FQU76_RS24465 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FQU76_RS24475 ENOG4108URH decarboxylase FQU76_RS24480 ENOG4105EMU Dehydrogenase FQU76_RS24490 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FQU76_RS24495 ENOG4105BZU Histidine kinase FQU76_RS24500 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FQU76_RS24505 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FQU76_RS24515 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FQU76_RS24525 ENOG4105EYF MMPL domain protein FQU76_RS24530 ENOG4105D9U N-acetyltransferase FQU76_RS24545 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS24555 ENOG4105D8V Glucose sorbosone dehydrogenase FQU76_RS24560 ENOG4105CPC Aldo Keto reductase FQU76_RS24570 ENOG4105BZU Histidine kinase FQU76_RS24580 ENOG4108ZP8 Acetolactate synthase small subunit FQU76_RS24585 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FQU76_RS24590 ENOG4108JQ1 Dehydrogenase FQU76_RS24595 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FQU76_RS24605 ENOG4105C26 Dehydrogenase FQU76_RS24610 ENOG410684T prevent-host-death family FQU76_RS24620 ENOG4105NPE arsR family transcriptional regulator FQU76_RS24635 ENOG4105KNE Phosphatidate cytidylyltransferase FQU76_RS24650 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FQU76_RS24655 ENOG4105CM2 brancheD-chain amino acid aminotransferase FQU76_RS24670 ENOG4105CQM Urea amidohydrolase subunit alpha FQU76_RS24675 ENOG4105DWY Agmatine deiminase FQU76_RS24705 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FQU76_RS24725 ENOG4108YYC ycei family FQU76_RS24730 ENOG4106AM8 polysaccharide lyase family 8 FQU76_RS24735 ENOG4105D8K carboxyl transferase FQU76_RS24755 ENOG4105GWZ Roadblock lc7 family protein FQU76_RS24775 ENOG4105GWZ Roadblock lc7 family protein FQU76_RS24785 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FQU76_RS24790 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FQU76_RS24825 ENOG41069M3 Transcriptional regulator FQU76_RS24830 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FQU76_RS24835 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FQU76_RS24845 ENOG4105K70 DNA-binding protein FQU76_RS24865 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FQU76_RS24870 ENOG4105CPF Cell wall formation (By similarity) FQU76_RS24890 ENOG4105DWF phosphomethylpyrimidine kinase FQU76_RS24895 ENOG4105VB9 50S ribosomal protein l28 FQU76_RS24900 ENOG4105DP4 dak2 domain fusion protein ylov FQU76_RS24910 ENOG4106H78 methyltransferase FQU76_RS24915 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FQU76_RS24930 ENOG41084BZ 50S ribosomal protein L32 FQU76_RS24935 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FQU76_RS24940 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FQU76_RS24945 ENOG4105K4I Scp-like extracellular FQU76_RS24950 ENOG4108375 Acylphosphatase (EC 3.6.1.7) FQU76_RS24965 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FQU76_RS25015 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FQU76_RS25025 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FQU76_RS25035 ENOG4105K5M 30s ribosomal protein S16 FQU76_RS25040 ENOG41082KU UPF0109 protein FQU76_RS25045 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FQU76_RS25050 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FQU76_RS25055 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FQU76_RS25075 ENOG4107QYR Signal peptidase i FQU76_RS25090 ENOG41080R2 UPF0102 protein FQU76_RS25105 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FQU76_RS25120 ENOG4105CE9 30S ribosomal protein S2 FQU76_RS25125 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FQU76_RS25130 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FQU76_RS25135 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FQU76_RS25145 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FQU76_RS25155 ENOG4108I5D sulfate abc transporter FQU76_RS25160 ENOG4108UCS ABC, transporter FQU76_RS25170 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FQU76_RS25175 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FQU76_RS25185 ENOG4105C26 Dehydrogenase FQU76_RS25195 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS25200 ENOG4105BZU Histidine kinase FQU76_RS25215 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FQU76_RS25225 ENOG4105C26 Dehydrogenase FQU76_RS25230 ENOG4107RUE extracellular solute-binding protein family 1 FQU76_RS25235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FQU76_RS25240 ENOG4105F38 ABC transporter, permease FQU76_RS25245 ENOG4105D38 putrescine abc transporter FQU76_RS25250 ENOG4105CJP fad dependent oxidoreductase FQU76_RS25280 ENOG4105G9B Transcriptional regulator FQU76_RS25285 ENOG4108PCN EamA-like transporter family FQU76_RS25290 ENOG4105C26 Dehydrogenase FQU76_RS25300 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FQU76_RS25305 ENOG4105DZP Membrane-associated zinc metalloprotease FQU76_RS25310 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FQU76_RS25325 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FQU76_RS25345 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) FQU76_RS25350 ENOG4105CHV Transcription elongation factor NusA FQU76_RS25360 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FQU76_RS25370 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FQU76_RS25375 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FQU76_RS25450 ENOG4108JQ7 (ABC) transporter FQU76_RS25460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS25465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FQU76_RS25470 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FQU76_RS25500 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS25515 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS25545 ENOG4105EC2 ftsk spoIIIe FQU76_RS25555 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FQU76_RS25560 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FQU76_RS25565 ENOG4105C1V Peptidase, M16 FQU76_RS25570 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FQU76_RS25595 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FQU76_RS25600 ENOG4105CN5 Metallo-Beta-Lactamase FQU76_RS25635 ENOG4105BZU Histidine kinase FQU76_RS25640 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FQU76_RS25645 ENOG4107QZI cell division protein FtsK FQU76_RS25665 ENOG4105CEV competence damage-inducible protein FQU76_RS25670 ENOG4105WBV Transcriptional regulator FQU76_RS25685 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FQU76_RS25690 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FQU76_RS25695 ENOG4107QRT dEAD DEAH box helicase FQU76_RS25745 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FQU76_RS25770 ENOG4105DRP amino acid AbC transporter FQU76_RS25775 ENOG4108Q1T ABC transporter FQU76_RS25780 ENOG4107UBR Extracellular solute-binding protein family 3 FQU76_RS25785 ENOG4105CDA abc transporter atp-binding protein FQU76_RS25790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS25795 ENOG4105EB3 Histidine kinase FQU76_RS25800 ENOG4105H1G trap transporter solute receptor taxi family FQU76_RS25805 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FQU76_RS25825 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FQU76_RS25835 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FQU76_RS25845 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FQU76_RS25855 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FQU76_RS25875 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FQU76_RS25880 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FQU76_RS25885 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FQU76_RS25920 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FQU76_RS25935 ENOG4105C9U ATP-dependent DNA helicase RecQ FQU76_RS25955 ENOG4105DRR Transcriptional regulator, GntR family FQU76_RS25960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FQU76_RS25975 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FQU76_RS25980 ENOG4105BZU Histidine kinase FQU76_RS25985 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS25990 ENOG4108MRH transcriptional regulatory protein FQU76_RS25995 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FQU76_RS26005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FQU76_RS26020 ENOG4105E4C Lytic transglycosylase catalytic FQU76_RS26025 ENOG4105DRR Transcriptional regulator, GntR family FQU76_RS26030 ENOG410849S phosphocarrier protein (HPr) FQU76_RS26040 ENOG4105CD5 CoA-binding domain protein FQU76_RS26055 ENOG4107W53 thymidine kinase FQU76_RS26180 ENOG4105KKJ Aminoglycoside phosphotransferase FQU76_RS26190 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FQU76_RS26245 ENOG4106S2D Transcriptional regulator FQU76_RS26270 ENOG4105CM4 permease protein FQU76_RS26275 ENOG4108IPW abc transporter atp-binding protein FQU76_RS26285 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS26300 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS26305 ENOG4105C29 acyl-CoA thioesterase FQU76_RS26310 ENOG410846T CoA-transferase family III FQU76_RS26330 ENOG410900P UPF0336 protein FQU76_RS26380 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FQU76_RS26400 ENOG4105VSH 4-oxalocrotonate tautomerase FQU76_RS26410 ENOG4107RSM transcriptional regulator FQU76_RS26415 ENOG4107R13 MMPL domain protein FQU76_RS26450 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FQU76_RS26465 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FQU76_RS26485 ENOG4105IJJ transcriptional regulator, crp fnr family FQU76_RS26535 ENOG4106NZI LysR family Transcriptional regulator FQU76_RS26555 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FQU76_RS26560 ENOG4105C0X amino acid FQU76_RS26565 ENOG4107VEG TrkA-N domain protein FQU76_RS26575 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FQU76_RS26610 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FQU76_RS26620 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FQU76_RS26645 ENOG4106F60 Histidine kinase FQU76_RS26650 ENOG4105F44 Two component transcriptional regulator, winged helix family FQU76_RS26660 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FQU76_RS26730 ENOG4107QK5 Homocysteine s-methyltransferase FQU76_RS26740 ENOG4107S1Q Phosphatase FQU76_RS26745 ENOG4105CEU Arginine dihydrolase FQU76_RS26750 ENOG4105DBV ornithine carbamoyltransferase FQU76_RS26755 ENOG4105CGU Enoyl-CoA hydratase FQU76_RS26810 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FQU76_RS26850 ENOG4105MXW flavin reductase domain protein, FMN-binding FQU76_RS26860 ENOG4108RVA ribokinase FQU76_RS26870 ENOG4105BZU Histidine kinase FQU76_RS26875 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS26880 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FQU76_RS26885 ENOG4107RBB ABC transporter, permease FQU76_RS26895 ENOG4105CFG Acts as a chaperone (By similarity) FQU76_RS26900 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FQU76_RS26910 ENOG4107QM5 aconitate hydratase FQU76_RS26935 ENOG4105E2R ROK family FQU76_RS26940 ENOG4105DFW ABC transporter FQU76_RS26945 ENOG4105C2J ABC transporter FQU76_RS26950 ENOG4108HWW ABC transporter FQU76_RS26955 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FQU76_RS26960 ENOG4105CUB amino acid FQU76_RS26970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FQU76_RS26975 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS26980 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FQU76_RS26995 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FQU76_RS27000 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FQU76_RS27015 ENOG4105C1Q protoporphyrinogen oxidase FQU76_RS27020 ENOG4107JTW chlorite dismutase FQU76_RS27055 ENOG4105E18 UPF0276 protein FQU76_RS27115 ENOG4105DFU Cell wall formation (By similarity) FQU76_RS27120 ENOG4105E0X reductase FQU76_RS27190 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component FQU76_RS27205 ENOG4107WA4 MmpL domain-containing protein FQU76_RS27225 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FQU76_RS27230 ENOG4108IY8 ABC, transporter FQU76_RS27255 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FQU76_RS27275 ENOG4107RR1 TRANSCRIPTIONal FQU76_RS27280 ENOG4105CSU acyl-Coa dehydrogenase FQU76_RS27315 ENOG4105EMN RNA polymerase sigma factor FQU76_RS27325 ENOG4105DY8 decarboxylase FQU76_RS27365 ENOG4108PDG Beta-ketoacyl synthase FQU76_RS27370 ENOG41079R3 acyl carrier protein FQU76_RS27380 ENOG4105KTE polyketide synthesis cyclase FQU76_RS27395 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FQU76_RS27420 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FQU76_RS27440 ENOG4105CPF Cell wall formation (By similarity) FQU76_RS27445 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FQU76_RS27450 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FQU76_RS27470 ENOG4105C7K acetolactate synthase FQU76_RS27495 ENOG4105DRR Transcriptional regulator, GntR family FQU76_RS27505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FQU76_RS27515 ENOG4107QKW extracellular solute-binding protein family 1 FQU76_RS27535 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FQU76_RS27565 ENOG4105ETE Transcriptional regulator (LacI family FQU76_RS27570 ENOG4105EAB amino acid AbC transporter FQU76_RS27575 ENOG4105EAD ABC transporter FQU76_RS27585 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FQU76_RS27595 ENOG4105F44 Two component transcriptional regulator, winged helix family FQU76_RS27600 ENOG4106F60 Histidine kinase FQU76_RS27605 ENOG4105JZI cytochrome P450 FQU76_RS27610 ENOG4108X7A Terpene synthase metal-binding domain-containing protein FQU76_RS27695 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FQU76_RS27710 ENOG41081F0 Precorrin-8x methylmutase FQU76_RS27715 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FQU76_RS27720 ENOG4105CTK cobaltochelatase, cobn subunit FQU76_RS27735 ENOG4105CIR epoxide hydrolase FQU76_RS27765 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FQU76_RS27770 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS27775 ENOG4105XYF acetyltransferase FQU76_RS27785 ENOG41060W2 glyoxylate carboligase FQU76_RS27795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FQU76_RS27800 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FQU76_RS27820 ENOG4105VT2 5-hydroxyisourate hydrolase FQU76_RS27830 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FQU76_RS27855 ENOG4105BZ1 (ABC) transporter FQU76_RS27860 ENOG4105BZ1 (ABC) transporter FQU76_RS27865 ENOG4108HUF Transporter FQU76_RS27870 ENOG4105DQ5 transport system permease protein FQU76_RS27875 ENOG4108IHU transport system permease protein FQU76_RS27880 ENOG4105E0A ABC, transporter FQU76_RS27915 ENOG41061H0 Monooxygenase FQU76_RS27920 ENOG4107R9S Malate synthase FQU76_RS27945 ENOG4105J4Q Transcriptional regulator FQU76_RS27955 ENOG4105DHG Allantoate amidinohydrolase FQU76_RS27970 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS27980 ENOG4105CK5 oxidoreductase FQU76_RS27995 ENOG4105CNN ABC, transporter FQU76_RS28000 ENOG4105C2J ABC transporter FQU76_RS28005 ENOG4105DKQ ROK family FQU76_RS28015 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FQU76_RS28035 ENOG4105CDA abc transporter atp-binding protein FQU76_RS28040 ENOG4107UBR Extracellular solute-binding protein family 3 FQU76_RS28045 ENOG4105EAD ABC transporter FQU76_RS28050 ENOG4105DRP amino acid AbC transporter FQU76_RS28055 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FQU76_RS28090 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FQU76_RS28105 ENOG4108W3Q Transcriptional regulator FQU76_RS28110 ENOG4108KQ5 Integrase catalytic subunit FQU76_RS28160 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FQU76_RS28170 ENOG4105ECY inositol monophosphatase FQU76_RS28180 ENOG4108UVJ appr-1-p processing domain protein FQU76_RS28200 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FQU76_RS28210 ENOG4105BZW Glycerate kinase FQU76_RS28230 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FQU76_RS28235 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS28245 ENOG4105CI0 Citrate lyase FQU76_RS28380 ENOG4107RHI Cytosine-specific methyltransferase FQU76_RS28545 ENOG4108ME1 Peptidase M55 D-aminopeptidase FQU76_RS28550 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FQU76_RS28560 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FQU76_RS28565 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FQU76_RS28580 ENOG4105D9U N-acetyltransferase FQU76_RS28585 ENOG4107HQ7 repeat protein FQU76_RS28670 ENOG4105CV8 reductase FQU76_RS28685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FQU76_RS28690 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FQU76_RS28700 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FQU76_RS28710 ENOG4105C2J ABC transporter FQU76_RS28715 ENOG4105CNN ABC, transporter FQU76_RS28720 ENOG4105DFW ABC transporter FQU76_RS28790 ENOG4108X7A Terpene synthase metal-binding domain-containing protein FQU76_RS28810 ENOG4105CPQ Dehydrogenase FQU76_RS28820 ENOG4105JZI cytochrome P450 FQU76_RS28870 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FQU76_RS28885 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FQU76_RS28890 ENOG4105C6Y Udp-glucose 6-dehydrogenase FQU76_RS28905 ENOG4108R85 Short chain dehydrogenase FQU76_RS28925 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FQU76_RS28950 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FQU76_RS28955 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FQU76_RS28960 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FQU76_RS28975 ENOG4105BZ1 (ABC) transporter FQU76_RS28980 ENOG4107S91 Sodium hydrogen exchanger FQU76_RS28995 ENOG4105C93 Xylose Isomerase FQU76_RS29000 ENOG4105DKQ ROK family FQU76_RS29060 ENOG4107YXZ hydrolase, family 25 FQU76_RS29070 ENOG4105K5B UPF0225 protein FQU76_RS29090 ENOG4105DQE DNA ligase FQU76_RS29115 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FQU76_RS29130 ENOG4105KF0 sporulation and cell division protein, SsgA FQU76_RS29140 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FQU76_RS29145 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FQU76_RS29150 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS29155 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FQU76_RS29185 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FQU76_RS29190 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FQU76_RS29205 ENOG4105C94 Transporter FQU76_RS29215 ENOG4105BZM domain protein FQU76_RS29220 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F FQU76_RS29250 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FQU76_RS29275 ENOG4108MDK Dehydrogenase FQU76_RS29290 ENOG4105FBD synthase FQU76_RS29300 ENOG4105CVN desaturase FQU76_RS29310 ENOG4105EWU Squalene--hopene cyclase FQU76_RS29350 ENOG4105E4C Lytic transglycosylase catalytic FQU76_RS29355 ENOG41090WU lipolytic protein G-D-S-L family FQU76_RS29420 ENOG4105D82 Glutamate dehydrogenase FQU76_RS29500 ENOG4105JZI cytochrome P450 FQU76_RS29530 ENOG4105JZI cytochrome P450 FQU76_RS29535 ENOG41068W2 Cytochrome p-450 FQU76_RS29540 ENOG4108X7A Terpene synthase metal-binding domain-containing protein FQU76_RS29595 ENOG4105F9F transposase FQU76_RS29630 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FQU76_RS29680 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FQU76_RS29715 ENOG4105BZ1 (ABC) transporter FQU76_RS29725 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FQU76_RS29755 ENOG4105BZ1 (ABC) transporter FQU76_RS29795 ENOG4105F7P transcriptional regulator AsnC family FQU76_RS29825 ENOG4108Z0R Transferase FQU76_RS29840 ENOG4105CAQ asparagine synthetase FQU76_RS29845 ENOG4107R13 MMPL domain protein FQU76_RS29860 ENOG4105DR5 peptidase FQU76_RS29895 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FQU76_RS29955 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FQU76_RS30000 ENOG41073B4 coagulation factor 5 8 type domain-containing protein FQU76_RS30025 ENOG4108KC1 acyl-Coa dehydrogenase FQU76_RS30030 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FQU76_RS30215 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS30220 ENOG4105BZU Histidine kinase FQU76_RS30250 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FQU76_RS30255 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FQU76_RS30260 ENOG4105C7S Dehydrogenase FQU76_RS30265 ENOG4105CPP Dehydrogenase, E1 component FQU76_RS30280 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS30290 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FQU76_RS30310 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS30355 ENOG4108JA1 polyketide synthase FQU76_RS30365 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS30415 ENOG4106NZI LysR family Transcriptional regulator FQU76_RS30420 ENOG4107RTG Major Facilitator superfamily FQU76_RS30440 ENOG4105DND Transcriptional regulator FQU76_RS30445 ENOG4106R7G Glycoside hydrolase family 5 FQU76_RS30450 ENOG4105JZI cytochrome P450 FQU76_RS30465 ENOG4105ECQ AraC Family Transcriptional Regulator FQU76_RS30470 ENOG4105ESN nucleotide-binding protein FQU76_RS30490 ENOG4105EVU fructokinase FQU76_RS30510 ENOG4105CBG Sulfatase FQU76_RS30595 ENOG4105C0K Gdp-mannose 4,6-dehydratase FQU76_RS30665 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FQU76_RS30740 ENOG4107Z6X Transcriptional regulator FQU76_RS30755 ENOG4106NZI LysR family Transcriptional regulator FQU76_RS30760 ENOG41061H0 Monooxygenase FQU76_RS30770 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) FQU76_RS30785 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FQU76_RS30790 ENOG4107TK4 histidinol-phosphate phosphatase FQU76_RS30805 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FQU76_RS30810 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FQU76_RS30815 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FQU76_RS30820 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FQU76_RS30825 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FQU76_RS30830 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FQU76_RS30835 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FQU76_RS30840 ENOG4105CHU acetyl-coa acetyltransferase FQU76_RS30855 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS30860 ENOG4105C26 Dehydrogenase FQU76_RS30870 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FQU76_RS30880 ENOG4105CR4 methylisocitrate lyase FQU76_RS30895 ENOG4105ECQ AraC Family Transcriptional Regulator FQU76_RS30940 ENOG4108RF4 Tetr family transcriptional regulator FQU76_RS30955 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS31005 ENOG4105VEQ Cold shock protein FQU76_RS31045 ENOG4106F1P AAA ATPase, central domain protein FQU76_RS31055 ENOG4105EC2 ftsk spoIIIe FQU76_RS31130 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FQU76_RS31135 ENOG4105CMT Dihydroxyacetone kinase FQU76_RS31150 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FQU76_RS31170 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FQU76_RS31185 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FQU76_RS31235 ENOG4108NEV two component transcriptional regulator, LytTR family FQU76_RS31255 ENOG4108HRK Histidine kinase FQU76_RS31305 ENOG4105BZU Histidine kinase FQU76_RS31310 ENOG4105C5Q Transcriptional regulator FQU76_RS31325 ENOG4105E33 succinate dehydrogenase FQU76_RS31335 ENOG4105WKW Pfam:DUF1458 FQU76_RS31345 ENOG41067HS methyltransferase FQU76_RS31350 ENOG4108V75 Glutamine amidotransferase FQU76_RS31355 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FQU76_RS31360 ENOG4105D1K glutamate--cysteine ligase FQU76_RS31370 ENOG41060NJ transcriptional regulator FQU76_RS31380 ENOG41080RH Thioredoxin FQU76_RS31385 ENOG4107QN2 dihydrolipoyl dehydrogenase FQU76_RS31415 ENOG4105W1Y Transcriptional regulator FQU76_RS31445 ENOG4105CHR reductase FQU76_RS31475 ENOG4105BZU Histidine kinase FQU76_RS31480 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS31485 ENOG4105D2S major facilitator superfamily FQU76_RS31495 ENOG41061MV Arylsulfatase FQU76_RS31530 ENOG4105CQM Urea amidohydrolase subunit alpha FQU76_RS31535 ENOG4105DWY Agmatine deiminase FQU76_RS31540 ENOG4105DEF Extracellular solute-binding protein, family 5 FQU76_RS31545 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FQU76_RS31550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS31565 ENOG4105DWY Agmatine deiminase FQU76_RS31570 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FQU76_RS31575 ENOG4106F1P AAA ATPase, central domain protein FQU76_RS31585 ENOG4105EC2 ftsk spoIIIe FQU76_RS31660 ENOG4108RJ9 Glycosyl transferase, family 2 FQU76_RS31670 ENOG4105C8Y Acetylornithine aminotransferase FQU76_RS31685 ENOG4105CND Glycosyl transferase, family 2 FQU76_RS31700 ENOG4105CPC Aldo Keto reductase FQU76_RS31720 ENOG4105DWV Homoserine O-trans-acetylase FQU76_RS31735 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FQU76_RS31745 ENOG4105DWY Agmatine deiminase FQU76_RS31790 ENOG4108PYU two-component system response regulator FQU76_RS31795 ENOG4108FKE two-component system sensor kinase FQU76_RS31800 ENOG41061WM D-Alanyl-D-Alanine FQU76_RS31810 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS31820 ENOG4105CGD Nad-dependent epimerase dehydratase FQU76_RS31830 ENOG41065SU Two-component system sensor kinase FQU76_RS31835 ENOG4108KXV response regulator FQU76_RS31850 ENOG4105FF0 ErfK YbiS YcfS YnhG FQU76_RS31860 ENOG4105EUB pirin domain protein FQU76_RS31880 ENOG41060M0 Crispr-associated protein, cse4 family FQU76_RS31885 ENOG4108VWQ crispr-associated protein FQU76_RS31895 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) FQU76_RS31900 ENOG4105PWE CRISPR-associated protein cas2 FQU76_RS31940 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FQU76_RS31975 ENOG4108KIH Inherit from NOG: halimadienyl-diphosphate synthase activity FQU76_RS31985 ENOG4105EUZ Beta-lactamase domain protein FQU76_RS32005 ENOG4105XPP Protein of unknown function (DUF1275) FQU76_RS32010 ENOG4108VGI doxx family FQU76_RS32015 ENOG4105CHJ isochorismatase hydrolase FQU76_RS32020 ENOG4105CPN adenine deaminase FQU76_RS32035 ENOG4105F9F transposase FQU76_RS32060 ENOG4107SFI Major Facilitator superfamily FQU76_RS32095 ENOG4105W1N transcriptional regulator FQU76_RS32110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FQU76_RS32115 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FQU76_RS32120 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FQU76_RS32145 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FQU76_RS32210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FQU76_RS32220 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS32250 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FQU76_RS32275 ENOG4105CHJ isochorismatase hydrolase FQU76_RS32300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FQU76_RS32305 ENOG4105BZU Histidine kinase FQU76_RS32320 ENOG4108KC1 acyl-Coa dehydrogenase FQU76_RS32350 ENOG4105C02 permease FQU76_RS32360 ENOG4107T94 Endo-14-beta-xylanase FQU76_RS32370 ENOG4105C5Q Transcriptional regulator FQU76_RS32385 ENOG4105CDA abc transporter atp-binding protein FQU76_RS32390 ENOG4105EAD ABC transporter FQU76_RS32395 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FQU76_RS32440 ENOG4105DEN Luciferase family FQU76_RS32445 ENOG4105XEA Tetr family transcriptional regulator FQU76_RS32455 ENOG4107SCK Monooxygenase FQU76_RS32510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS32540 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FQU76_RS32550 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS32560 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FQU76_RS32580 ENOG4108ZJ4 polysaccharide deacetylase FQU76_RS32610 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin FQU76_RS32625 ENOG4105CHR reductase FQU76_RS32630 ENOG4108X0B nad(p)h dehydrogenase (quinone) FQU76_RS32655 ENOG4105E98 transcriptional regulator DeoR family FQU76_RS32665 ENOG4108M1A Chitin-binding protein FQU76_RS32675 ENOG4107QTZ amino acid FQU76_RS32680 ENOG4107SQD Transcriptional regulator, GntR family FQU76_RS32695 ENOG4105E90 ABC transporter FQU76_RS32700 ENOG4105E90 ABC transporter FQU76_RS32715 ENOG4108IJ8 ABC transporter FQU76_RS32720 ENOG4107SMB hydrolase Family 5 FQU76_RS32765 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FQU76_RS32770 ENOG4105C3U ABC transporter FQU76_RS32775 ENOG4108JQ7 (ABC) transporter FQU76_RS32795 ENOG410880H cysteine synthase FQU76_RS32840 ENOG4105WH1 Two component transcriptional regulator luxr family FQU76_RS32860 ENOG4105VUN Transcriptional regulator FQU76_RS32865 ENOG4108KPJ rna polymerase sigma factor FQU76_RS32915 ENOG4107RR1 TRANSCRIPTIONal FQU76_RS32930 ENOG4105C0D helicase FQU76_RS32945 ENOG4105GWZ Roadblock lc7 family protein FQU76_RS32960 ENOG4105CPQ Dehydrogenase FQU76_RS32965 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FQU76_RS32970 ENOG4105JQN Transcriptional regulator FQU76_RS33020 ENOG4105DBM Siderophore biosynthesis protein FQU76_RS33055 ENOG4105D22 carbon starvation protein FQU76_RS33060 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FQU76_RS33065 ENOG4105JZI cytochrome P450 FQU76_RS33095 ENOG4105D44 asparaginase FQU76_RS33105 ENOG4108Q5F Tetr family transcriptional regulator FQU76_RS33120 ENOG4105CSH Transporter FQU76_RS33150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FQU76_RS33160 ENOG4108Z6Z Transcriptional regulator FQU76_RS33190 ENOG4105CHR reductase FQU76_RS33195 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FQU76_RS33205 ENOG4107SM8 Adenylate Guanylate cyclase FQU76_RS33225 ENOG4105C1G acyl-Coa dehydrogenase FQU76_RS33230 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FQU76_RS33235 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FQU76_RS33240 ENOG4107RNB anthranilate phosphoribosyltransferase FQU76_RS33290 ENOG4105BZU Histidine kinase FQU76_RS33300 ENOG4105CJ1 ABC, transporter FQU76_RS33330 ENOG4105CIH Imidazole acetol-phosphate transaminase FQU76_RS33335 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FQU76_RS33375 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FQU76_RS33420 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FQU76_RS33445 ENOG41065KQ synthase FQU76_RS33455 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FQU76_RS33460 ENOG4105CS1 NAD(P)H quinone oxidoreductase FQU76_RS33475 ENOG4105JAB phenazine biosynthesis protein, phzf family FQU76_RS33495 ENOG4106SDP Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control FQU76_RS33505 ENOG4108ES0 acetoacetyl-CoA synthetase FQU76_RS33510 ENOG41065KQ synthase FQU76_RS33515 ENOG4108KPJ rna polymerase sigma factor FQU76_RS33545 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS33545 ENOG4105CEY Amp-dependent synthetase and ligase FQU76_RS33565 ENOG4105YVS arsR family transcriptional regulator FQU76_RS33630 ENOG4105EBM Alpha Beta Hydrolase Fold protein FQU76_RS33635 ENOG4105F0K SARP family transcriptional regulator FQU76_RS33685 ENOG4105CHP RNA polymerase FQU76_RS33735 ENOG4105MN3 Resolvase