locus-tag class description FGW37_RS00085 ENOG4105EMU Dehydrogenase FGW37_RS00115 ENOG4108KPJ rna polymerase sigma factor FGW37_RS00120 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FGW37_RS00125 ENOG4105ETX regulatoR FGW37_RS00130 ENOG4106F60 Histidine kinase FGW37_RS00150 ENOG4105CJ1 ABC, transporter FGW37_RS00200 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FGW37_RS00260 ENOG41068W2 Cytochrome p-450 FGW37_RS00265 ENOG4105DMT epimerase dehydratase FGW37_RS00290 ENOG4107R13 MMPL domain protein FGW37_RS00305 ENOG4105KAF membrAne FGW37_RS00355 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FGW37_RS00385 ENOG4105F0K SARP family transcriptional regulator FGW37_RS00390 ENOG41082W1 Cupin 2, conserved barrel domain protein FGW37_RS00395 ENOG4105ECQ AraC Family Transcriptional Regulator FGW37_RS00400 ENOG4105KNA -acetyltransferase FGW37_RS00410 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FGW37_RS00440 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FGW37_RS00445 ENOG4105EEF Alkane 1-monooxygenase FGW37_RS00450 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FGW37_RS00480 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS00500 ENOG4105BZ1 (ABC) transporter FGW37_RS00525 ENOG4105DMF Dehydrogenase FGW37_RS00625 ENOG4107SCK Monooxygenase FGW37_RS00640 ENOG4108KE4 O-methyltransferase FGW37_RS00650 ENOG4107R6D beta-lactam binding protein AmpH FGW37_RS00655 ENOG41065KQ synthase FGW37_RS00670 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FGW37_RS00700 ENOG4105HHS UPF0256 protein FGW37_RS00730 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FGW37_RS00765 ENOG4105EFZ amidohydrolase FGW37_RS00785 ENOG4105CIR epoxide hydrolase FGW37_RS00790 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FGW37_RS00800 ENOG4105GRZ Ycii-related protein FGW37_RS00810 ENOG4105CPC Aldo Keto reductase FGW37_RS00895 ENOG4105CJ1 ABC, transporter FGW37_RS00915 ENOG4105CH2 amidohydrolase FGW37_RS00950 ENOG4105PDP Short chain dehydrogenase FGW37_RS00960 ENOG4108762 serine threonine protein kinase FGW37_RS00965 ENOG4108762 serine threonine protein kinase FGW37_RS00970 ENOG4107S2E monooxygenase FGW37_RS00995 ENOG4108VQT Alpha beta hydrolase fold protein FGW37_RS01015 ENOG4108D32 Methyltransferase FGW37_RS01020 ENOG4105S6R Iron-hydroxamate transporter permease subunit FGW37_RS01025 ENOG4108HUF Transporter FGW37_RS01030 ENOG4105E0A ABC, transporter FGW37_RS01035 ENOG4105CNH Multidrug resistance protein MdtL FGW37_RS01045 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FGW37_RS01060 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FGW37_RS01065 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FGW37_RS01070 ENOG4105Q33 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency FGW37_RS01085 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FGW37_RS01090 ENOG4108KPJ rna polymerase sigma factor FGW37_RS01095 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FGW37_RS01100 ENOG4105CHH sulfate transporter FGW37_RS01105 ENOG4105EEM helicase FGW37_RS01135 ENOG4105DNP FAD linked oxidase domain protein FGW37_RS01140 ENOG4107Y2X deaminase FGW37_RS01175 ENOG410630P Transcriptional regulator FGW37_RS01180 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FGW37_RS01220 ENOG4105C0R drug resistance transporter emrb qaca subfamily FGW37_RS01225 ENOG4107QYR Signal peptidase i FGW37_RS01305 ENOG4105WQT MbtH domain protein FGW37_RS01315 ENOG4105EV8 ectoine hydroxylase FGW37_RS01320 ENOG4108ZXC Two component transcriptional regulator, luxr family FGW37_RS01340 ENOG4106A3M Cytochrome p-450 FGW37_RS01350 ENOG4105CMG Carbohydrate kinase FGW37_RS01355 ENOG4105CMG Carbohydrate kinase FGW37_RS01385 ENOG4107S9F NmrA family FGW37_RS01400 ENOG4107R8N Glycosyl transferase, family 2 FGW37_RS01410 ENOG4108JJB ABC transporter FGW37_RS01455 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS01460 ENOG4105BZU Histidine kinase FGW37_RS01470 ENOG4105BZU Histidine kinase FGW37_RS01475 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS01510 ENOG4105EAH synthase FGW37_RS01535 ENOG4105CC5 ABC transporter FGW37_RS01540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS01545 ENOG4105DSE periplasmic solute binding protein FGW37_RS01565 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS01580 ENOG4105VZ8 Transcriptional regulator FGW37_RS01605 ENOG41061H0 Monooxygenase FGW37_RS01630 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FGW37_RS01635 ENOG4106NZI LysR family Transcriptional regulator FGW37_RS01690 ENOG4105CR4 methylisocitrate lyase FGW37_RS01695 ENOG4105E0F Histidine kinase FGW37_RS01700 ENOG4105ETX regulatoR FGW37_RS01720 ENOG4105D7N magnesium and cobalt transport protein CorA FGW37_RS01725 ENOG4105EBR Carboxylesterase FGW37_RS01740 ENOG4108VQT Alpha beta hydrolase fold protein FGW37_RS01750 ENOG4105D9U N-acetyltransferase FGW37_RS01795 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FGW37_RS01875 ENOG4108PA7 Methyltransferase FGW37_RS01885 ENOG4105ESN nucleotide-binding protein FGW37_RS01915 ENOG4105CSH Transporter FGW37_RS01955 ENOG4105DRR Transcriptional regulator, GntR family FGW37_RS01965 ENOG4105CTU Proline racemase FGW37_RS01970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FGW37_RS01975 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FGW37_RS01985 ENOG4105MWK D-amino acid dehydrogenase, small subunit FGW37_RS01990 ENOG4107T6F Xaa-Pro aminopeptidase FGW37_RS02000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS02010 ENOG4105C3U ABC transporter FGW37_RS02015 ENOG4108JQ7 (ABC) transporter FGW37_RS02030 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FGW37_RS02035 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FGW37_RS02045 ENOG4108YV4 Universal stress protein FGW37_RS02055 ENOG4108NNZ chitinase FGW37_RS02060 ENOG410804D Sensor Signal Transduction Histidine Kinase FGW37_RS02065 ENOG4108RQS Two component transcriptional regulator (Winged helix family FGW37_RS02080 ENOG4105CM2 brancheD-chain amino acid aminotransferase FGW37_RS02115 ENOG4105CGD Nad-dependent epimerase dehydratase FGW37_RS02125 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FGW37_RS02140 ENOG4105KV4 Transcriptional regulator FGW37_RS02145 ENOG4105F27 Major Facilitator FGW37_RS02160 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FGW37_RS02165 ENOG4108ZHJ Organic hydroperoxide resistance protein FGW37_RS02170 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FGW37_RS02180 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FGW37_RS02185 ENOG4105D52 delta-aminolevulinic acid dehydratase FGW37_RS02220 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FGW37_RS02225 ENOG4105F27 Major Facilitator FGW37_RS02230 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FGW37_RS02245 ENOG41067SE Tetr family transcriptional regulator FGW37_RS02255 ENOG4105EWK phytoene FGW37_RS02280 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FGW37_RS02285 ENOG4105W1N transcriptional regulator FGW37_RS02295 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FGW37_RS02315 ENOG4105BZ9 Cytochrome C oxidase, subunit I FGW37_RS02320 ENOG4108XNA Gas vesicle FGW37_RS02325 ENOG4107ETC gas vesicle protein FGW37_RS02335 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) FGW37_RS02350 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth FGW37_RS02390 ENOG4108YYH Nadph-dependent fmn reductase FGW37_RS02440 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FGW37_RS02485 ENOG4105C8Y Acetylornithine aminotransferase FGW37_RS02490 ENOG4105MWK D-amino acid dehydrogenase, small subunit FGW37_RS02495 ENOG4105CKK Glycosyl transferase, family 2 FGW37_RS02510 ENOG4107TB5 TRANSCRIPTIONal FGW37_RS02525 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS02540 ENOG4105C19 ABC transporter FGW37_RS02550 ENOG4108JA1 polyketide synthase FGW37_RS02590 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FGW37_RS02620 ENOG4106YKD Cytochrome p-450 FGW37_RS02625 ENOG4106YKD Cytochrome p-450 FGW37_RS02635 ENOG4105K63 Thioredoxin FGW37_RS02665 ENOG4105C87 Aminotransferase class I and II FGW37_RS02670 ENOG4108Z40 Transcriptional regulator FGW37_RS02675 ENOG4108JA1 polyketide synthase FGW37_RS02680 ENOG4105VEQ Cold shock protein FGW37_RS02700 ENOG4105F04 LysR family Transcriptional regulator FGW37_RS02725 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FGW37_RS02730 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FGW37_RS02735 ENOG4105C7W Xanthine dehydrogenase FGW37_RS02745 ENOG4105CIG ABC transporter FGW37_RS02765 ENOG4108HMN Caspase domain FGW37_RS02785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FGW37_RS02790 ENOG4105BZU Histidine kinase FGW37_RS02795 ENOG4105DKK Benzoate FGW37_RS02800 ENOG4107Y2X deaminase FGW37_RS02805 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FGW37_RS02810 ENOG4107B2H carbonic anhydrase FGW37_RS02815 ENOG4108Q50 Histidine kinase FGW37_RS02835 ENOG4108KP7 hydrolase FGW37_RS02865 ENOG4108ZGX Histidine kinase FGW37_RS02870 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS02890 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FGW37_RS02910 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS02925 ENOG4105C0W non-ribosomal peptide synthetase FGW37_RS02975 ENOG4105DJ4 phosphatidylserine decarboxylase FGW37_RS02990 ENOG4105BZU Histidine kinase FGW37_RS03005 ENOG4105E8G Major facilitator Superfamily FGW37_RS03015 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FGW37_RS03055 ENOG4107QIZ NADH dehydrogenase FGW37_RS03100 ENOG4105MXW flavin reductase domain protein, FMN-binding FGW37_RS03110 ENOG4108JQ1 Dehydrogenase FGW37_RS03115 ENOG4105DTQ mandelate racemase muconate lactonizing FGW37_RS03125 ENOG4107QM5 aconitate hydratase FGW37_RS03140 ENOG4105BZN citrate synthase FGW37_RS03160 ENOG4105DZ1 carboxypeptidase FGW37_RS03165 ENOG4105CPQ Dehydrogenase FGW37_RS03170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FGW37_RS03175 ENOG4105JQN Transcriptional regulator FGW37_RS03185 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FGW37_RS03205 ENOG4105CAQ asparagine synthetase FGW37_RS03220 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS03225 ENOG4108ES0 acetoacetyl-CoA synthetase FGW37_RS03230 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FGW37_RS03245 ENOG4105CHR reductase FGW37_RS03250 ENOG4105CFG Acts as a chaperone (By similarity) FGW37_RS03270 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FGW37_RS03280 ENOG4105F0K SARP family transcriptional regulator FGW37_RS03300 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) FGW37_RS03320 ENOG4108ZJ4 polysaccharide deacetylase FGW37_RS03330 ENOG4105K5B UPF0225 protein FGW37_RS03355 ENOG4108IAJ Nad-dependent epimerase dehydratase FGW37_RS03365 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FGW37_RS03435 ENOG4105W1N transcriptional regulator FGW37_RS03475 ENOG4105E39 Enoyl-CoA hydratase FGW37_RS03490 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS03520 ENOG4107TXC Transcriptional regulator FGW37_RS03685 ENOG4105X7H acyl-CoA dehydrogenase FGW37_RS03750 ENOG4105BZU Histidine kinase FGW37_RS03755 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS03785 ENOG4105D44 asparaginase FGW37_RS03790 ENOG4105JZI cytochrome P450 FGW37_RS03805 ENOG4105F6E Acyl-transferase FGW37_RS03830 ENOG4105D74 hydrolase FGW37_RS03860 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FGW37_RS03865 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS03875 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FGW37_RS03885 ENOG4105F1K Glutamine amidotransferase FGW37_RS03890 ENOG4105CTQ phosphohexokinase FGW37_RS03930 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FGW37_RS03940 ENOG4105CQM Urea amidohydrolase subunit alpha FGW37_RS03945 ENOG4105KI2 Urea amidohydrolase subunit beta FGW37_RS03950 ENOG4108YZ9 Urea amidohydrolase subunit gamma FGW37_RS03975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FGW37_RS03980 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FGW37_RS03985 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FGW37_RS03990 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FGW37_RS03995 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FGW37_RS04020 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FGW37_RS04025 ENOG4108KPJ rna polymerase sigma factor FGW37_RS04030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FGW37_RS04035 ENOG4105FDP GntR family transcriptional regulator FGW37_RS04040 ENOG4105DKQ ROK family FGW37_RS04045 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS04050 ENOG4105BZU Histidine kinase FGW37_RS04065 ENOG4108VCA G U mismatch-specific DNA glycosylase FGW37_RS04070 ENOG4105C83 adenylosuccinate lyase FGW37_RS04090 ENOG4107QN2 dihydrolipoyl dehydrogenase FGW37_RS04125 ENOG4105EYH Exonuclease FGW37_RS04135 ENOG4107T94 Endo-14-beta-xylanase FGW37_RS04140 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FGW37_RS04145 ENOG4105K4P CoA-binding domain protein FGW37_RS04185 ENOG4105KTE polyketide synthesis cyclase FGW37_RS04195 ENOG4105CZS beta-ketoacyl synthase FGW37_RS04215 ENOG4107SCK Monooxygenase FGW37_RS04220 ENOG4105D8K carboxyl transferase FGW37_RS04230 ENOG4108M8W Monooxygenase FGW37_RS04235 ENOG4105C57 major facilitator superfamily FGW37_RS04300 ENOG4105DU1 integral membrane protein, terc FGW37_RS04305 ENOG4105CHH sulfate transporter FGW37_RS04330 ENOG4108X7A Terpene synthase metal-binding domain-containing protein FGW37_RS04350 ENOG4108UW5 maltose o-acetyltransferase FGW37_RS04370 ENOG4108ZXC Two component transcriptional regulator, luxr family FGW37_RS04395 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FGW37_RS04410 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FGW37_RS04435 ENOG4105K4I Scp-like extracellular FGW37_RS04475 ENOG4105DCG PHP domain protein FGW37_RS04480 ENOG4105DQE DNA ligase FGW37_RS04485 ENOG4105DQE DNA ligase FGW37_RS04490 ENOG4105FDF Could be involved in DNA repair (By similarity) FGW37_RS04525 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FGW37_RS04530 ENOG4105EP9 oxidoreductase FGW37_RS04545 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FGW37_RS04550 ENOG4105CHR reductase FGW37_RS04585 ENOG4105DND Transcriptional regulator FGW37_RS04590 ENOG4108Q5Y Membrane FGW37_RS04595 ENOG4105CSW GntR family transcriptional regulator FGW37_RS04625 ENOG4105JAB phenazine biosynthesis protein, phzf family FGW37_RS04650 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FGW37_RS04660 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FGW37_RS04680 ENOG4108UW8 fha domain-containing protein FGW37_RS04730 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FGW37_RS04750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FGW37_RS04760 ENOG4108UQS dipeptidase FGW37_RS04765 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FGW37_RS04780 ENOG4105GWZ Roadblock lc7 family protein FGW37_RS04820 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FGW37_RS04835 ENOG41073TP transcriptional regulator FGW37_RS04840 ENOG4105E7W lamb ycsf family protein FGW37_RS04845 ENOG4105P4J Allophanate hydrolase, subunit 1 FGW37_RS04850 ENOG4107R7A Allophanate hydrolase subunit 2 FGW37_RS04890 ENOG4105ETX regulatoR FGW37_RS04900 ENOG4107QHZ cell cycle protein FGW37_RS04910 ENOG4105EBR Carboxylesterase FGW37_RS04915 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) FGW37_RS04985 ENOG4108IAJ Nad-dependent epimerase dehydratase FGW37_RS04995 ENOG4105JXB ankyrin repeat-containing protein FGW37_RS05010 ENOG41073TP transcriptional regulator FGW37_RS05020 ENOG4105Q70 FGW37_RS05030 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FGW37_RS05045 ENOG4105EW9 transcriptional regulator AsnC family FGW37_RS05055 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS05070 ENOG4108UTZ Dihydroxyacetone kinase FGW37_RS05090 ENOG4105EHG Permease protein FGW37_RS05095 ENOG4105E0A ABC, transporter FGW37_RS05145 ENOG4107RR1 TRANSCRIPTIONal FGW37_RS05155 ENOG4107Y5K Resolvase FGW37_RS05320 ENOG4108FKH Transglycosylase SLT domain FGW37_RS05440 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FGW37_RS05450 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FGW37_RS05455 ENOG4105D52 delta-aminolevulinic acid dehydratase FGW37_RS05495 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FGW37_RS05520 ENOG4105C57 major facilitator superfamily FGW37_RS05580 ENOG4105C2W permease FGW37_RS05615 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FGW37_RS05620 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FGW37_RS05625 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase FGW37_RS05630 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FGW37_RS05705 ENOG4106NZI LysR family Transcriptional regulator FGW37_RS05710 ENOG4105F27 Major Facilitator FGW37_RS05735 ENOG4108IXY short-chain dehydrogenase reductase FGW37_RS05740 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FGW37_RS05750 ENOG4105DKT Transcriptional regulator FGW37_RS05755 ENOG4105DJV ribulose-phosphate 3-epimerase FGW37_RS05765 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FGW37_RS05780 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FGW37_RS05805 ENOG4105SKN orotidine 5''-phosphate decarboxylase FGW37_RS05810 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FGW37_RS05815 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FGW37_RS05820 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FGW37_RS05830 ENOG4105CD3 dihydroorotase FGW37_RS05835 ENOG4105CXT aspartate transcarbamylase FGW37_RS05840 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FGW37_RS05850 ENOG410803B Involved in the transcription termination process (By similarity) FGW37_RS05855 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FGW37_RS05860 ENOG4105DC7 peptidase M24 FGW37_RS05870 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FGW37_RS05875 ENOG4105D49 3-dehydroquinate synthase FGW37_RS05880 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FGW37_RS05885 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FGW37_RS05890 ENOG4105E2X shikimate dehydrogenase FGW37_RS05895 ENOG4105HHA aminodeoxychorismate lyase FGW37_RS05900 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FGW37_RS05905 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FGW37_RS05925 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FGW37_RS05945 ENOG4105CUT histidyl-tRNA synthetase FGW37_RS05955 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) FGW37_RS05960 ENOG4105C99 atpase involved in dna repair FGW37_RS05965 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FGW37_RS05970 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FGW37_RS05975 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FGW37_RS05980 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FGW37_RS05990 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FGW37_RS05995 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FGW37_RS06000 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FGW37_RS06005 ENOG4105CDY transcriptional regulatory protein FGW37_RS06010 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FGW37_RS06015 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FGW37_RS06025 ENOG4105E2K Glycosyl transferase (Group 1 FGW37_RS06030 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase FGW37_RS06065 ENOG4105C22 threonyL-tRNA synthetase FGW37_RS06080 ENOG4108JDX DNA polymerase iii, epsilon subunit FGW37_RS06105 ENOG4105KF0 sporulation and cell division protein, SsgA FGW37_RS06130 ENOG4105F0I Aminotransferase FGW37_RS06135 ENOG4105CRQ synthase (Component I) FGW37_RS06185 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FGW37_RS06190 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FGW37_RS06205 ENOG4105D01 (LipO)protein FGW37_RS06210 ENOG4108UMI ABC transporter, permease FGW37_RS06215 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS06255 ENOG4105C57 major facilitator superfamily FGW37_RS06260 ENOG4105RJZ Transcriptional regulator FGW37_RS06265 ENOG4105CH7 arginosuccinase FGW37_RS06270 ENOG4105CDH Citrulline--aspartate ligase FGW37_RS06285 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FGW37_RS06290 ENOG4105C8Y Acetylornithine aminotransferase FGW37_RS06295 ENOG4105CAS nag kinase FGW37_RS06300 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FGW37_RS06305 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FGW37_RS06320 ENOG4105E9K Isocitrate dehydrogenase FGW37_RS06330 ENOG4108KTG Membrane protein, drug metabolite transporter FGW37_RS06345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FGW37_RS06350 ENOG4105T38 integral membrane protein FGW37_RS06360 ENOG4105F32 YngK protein FGW37_RS06390 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FGW37_RS06395 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FGW37_RS06400 ENOG4105BZU Histidine kinase FGW37_RS06405 ENOG4108RWN rrna methyltransferase FGW37_RS06410 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FGW37_RS06415 ENOG41084BS 50S ribosomal protein L35 FGW37_RS06420 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FGW37_RS06430 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FGW37_RS06475 ENOG41073TP transcriptional regulator FGW37_RS06480 ENOG4105C85 amino acid FGW37_RS06485 ENOG4108Z86 Glutamine amidotransferase FGW37_RS06510 ENOG4108IJ7 Glycine betaine FGW37_RS06515 ENOG4105HFS 5'-3' exonuclease FGW37_RS06535 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FGW37_RS06540 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FGW37_RS06560 ENOG4108FFZ Transcriptional regulator FGW37_RS06570 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FGW37_RS06575 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) FGW37_RS06585 ENOG4105ETE Transcriptional regulator (LacI family FGW37_RS06590 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FGW37_RS06595 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FGW37_RS06605 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) FGW37_RS06610 ENOG4105E5F proteasome FGW37_RS06615 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FGW37_RS06645 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS06655 ENOG4108HIY periplasmic FGW37_RS06660 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FGW37_RS06675 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FGW37_RS06680 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FGW37_RS06685 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FGW37_RS06690 ENOG4108K8U Glycerol operon regulatory protein FGW37_RS06695 ENOG4105C3R Methionine synthase FGW37_RS06710 ENOG4105C8N cysteinyl-tRNA synthetase FGW37_RS06730 ENOG4105D7N magnesium and cobalt transport protein CorA FGW37_RS06740 ENOG4105DYW oxidoreductase FGW37_RS06745 ENOG4105CPC Aldo Keto reductase FGW37_RS06775 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FGW37_RS06805 ENOG4106V2I dimethylaminohydrolase FGW37_RS06830 ENOG4105PTV Nudix Hydrolase FGW37_RS06840 ENOG4105C57 major facilitator superfamily FGW37_RS06845 ENOG410834F Transcriptional regulator FGW37_RS06880 ENOG4108Z4X TRANSCRIPTIONal FGW37_RS06900 ENOG4105EHZ conserved protein UCP016719 FGW37_RS06910 ENOG4108IG5 Transcriptional regulator FGW37_RS06920 ENOG4105F1J Homogentisate 1,2-dioxygenase FGW37_RS06950 ENOG4107TPY serine threonine protein kinase FGW37_RS06955 ENOG4108TCJ secreted hydrolase FGW37_RS07000 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FGW37_RS07005 ENOG4105CAQ asparagine synthetase FGW37_RS07015 ENOG4105DBM Siderophore biosynthesis protein FGW37_RS07020 ENOG4105C6X Major Facilitator FGW37_RS07035 ENOG4108MES Periplasmic binding protein FGW37_RS07040 ENOG4105E0A ABC, transporter FGW37_RS07045 ENOG4105DQ5 transport system permease protein FGW37_RS07050 ENOG4105DQ5 transport system permease protein FGW37_RS07065 ENOG4105DVH amino acid FGW37_RS07095 ENOG4105C0B DNA polymerase III (alpha subunit) FGW37_RS07100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FGW37_RS07115 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FGW37_RS07130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FGW37_RS07135 ENOG4108J59 Extracellular solute-binding protein, family 5 FGW37_RS07140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS07160 ENOG4106NMR serine protease FGW37_RS07185 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FGW37_RS07190 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS07195 ENOG4105C57 major facilitator superfamily FGW37_RS07205 ENOG410841Q phosphoesterase PA-phosphatase related protein FGW37_RS07215 ENOG4105BZ9 Cytochrome C oxidase, subunit I FGW37_RS07225 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FGW37_RS07240 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FGW37_RS07250 ENOG4105CAT Cytidine monophosphate kinase FGW37_RS07270 ENOG4105FE9 pseudouridine synthase FGW37_RS07275 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FGW37_RS07280 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FGW37_RS07295 ENOG4105DCF alanine dehydrogenase FGW37_RS07305 ENOG4108YZ4 nudix hydrolase FGW37_RS07310 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FGW37_RS07315 ENOG4105BZP glycoside hydrolase 15-related FGW37_RS07320 ENOG4105DXI Major Facilitator superfamily FGW37_RS07330 ENOG4105DDN Pentapeptide repeat-containing protein FGW37_RS07335 ENOG4107QPH glycogen) synthase FGW37_RS07345 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FGW37_RS07355 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FGW37_RS07375 ENOG4105E0A ABC, transporter FGW37_RS07380 ENOG4105TVJ transport system, permease FGW37_RS07385 ENOG4105DQ5 transport system permease protein FGW37_RS07400 ENOG4105DSU hydrolase FGW37_RS07430 ENOG4108VX5 3-methyladenine DNA glycosylase FGW37_RS07450 ENOG4108V1U phospholipid-binding protein FGW37_RS07475 ENOG4105DKW ABC transporter FGW37_RS07495 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS07500 ENOG4105BZU Histidine kinase FGW37_RS07510 ENOG4108FKH Transglycosylase SLT domain FGW37_RS07515 ENOG4105IDI abc transporter atp-binding protein FGW37_RS07525 ENOG4105EAC phosphoserine phosphatase FGW37_RS07540 ENOG4105DJ2 Major Facilitator Superfamily FGW37_RS07545 ENOG4107YCY Transcriptional regulator FGW37_RS07555 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FGW37_RS07560 ENOG4105CHR reductase FGW37_RS07575 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FGW37_RS07580 ENOG4105Y3U Transglycosylase-associated protein FGW37_RS07595 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FGW37_RS07600 ENOG4107QN1 sodium solute FGW37_RS07625 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FGW37_RS07635 ENOG4105BZP glycoside hydrolase 15-related FGW37_RS07640 ENOG4105CHR reductase FGW37_RS07665 ENOG4105VBF alkaline shock protein FGW37_RS07685 ENOG4106YT9 Enoyl-CoA hydratase FGW37_RS07695 ENOG4105C5H ABC transporter FGW37_RS07725 ENOG4107W7X Aldolase FGW37_RS07740 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FGW37_RS07745 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FGW37_RS07760 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FGW37_RS07780 ENOG4105C09 Bile acid FGW37_RS07790 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase FGW37_RS07800 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FGW37_RS07805 ENOG4105EV8 ectoine hydroxylase FGW37_RS07810 ENOG4105C9B Cysteine desulfurase FGW37_RS07820 ENOG4105BZU Histidine kinase FGW37_RS07835 ENOG4105E9Z Nad-dependent epimerase dehydratase FGW37_RS07845 ENOG4105DEN Luciferase family FGW37_RS07865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FGW37_RS07870 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FGW37_RS07880 ENOG4105DWY Agmatine deiminase FGW37_RS07890 ENOG4108UNV SUF system FeS assembly protein, NifU family FGW37_RS07895 ENOG4105C9B Cysteine desulfurase FGW37_RS07900 ENOG4105C3K feS assembly ATPase SufC FGW37_RS07910 ENOG4105JRK feS assembly protein SufD FGW37_RS07925 ENOG4105CJ1 ABC, transporter FGW37_RS07935 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FGW37_RS07950 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FGW37_RS07955 ENOG4105CV1 Transketolase (EC 2.2.1.1) FGW37_RS07960 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FGW37_RS07975 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) FGW37_RS07980 ENOG4107QP8 phosphohexose isomerase FGW37_RS07995 ENOG4105CP7 Triose-phosphate isomerase FGW37_RS08000 ENOG4105BZA Phosphoglycerate kinase FGW37_RS08005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FGW37_RS08015 ENOG4105CIE May be required for sporulation (By similarity) FGW37_RS08020 ENOG4105CHW UPF0052 protein FGW37_RS08025 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FGW37_RS08030 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FGW37_RS08060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FGW37_RS08075 ENOG4105CSH Transporter FGW37_RS08095 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FGW37_RS08100 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FGW37_RS08105 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FGW37_RS08140 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FGW37_RS08150 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FGW37_RS08155 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FGW37_RS08160 ENOG4105CQ7 ATP-dependent helicase FGW37_RS08170 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FGW37_RS08190 ENOG4105KA0 thioesterase Superfamily protein FGW37_RS08205 ENOG4105C32 Amino acid ABC transporter (Permease) FGW37_RS08210 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FGW37_RS08215 ENOG4105C0Z ABC transporter FGW37_RS08220 ENOG4108IV0 ABC, transporter FGW37_RS08250 ENOG4105CGH 5'-nucleotidase FGW37_RS08265 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FGW37_RS08275 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FGW37_RS08280 ENOG41075H3 AraC family transcriptional regulator FGW37_RS08285 ENOG4105ESP cell wall surface anchor family protein FGW37_RS08295 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FGW37_RS08305 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS08345 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FGW37_RS08360 ENOG4105CBC glutamate synthase FGW37_RS08370 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FGW37_RS08380 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FGW37_RS08385 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FGW37_RS08390 ENOG4105DK0 Indole-3-glycerol phosphate synthase FGW37_RS08410 ENOG4105CRQ synthase (Component I) FGW37_RS08415 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FGW37_RS08430 ENOG4108VGI doxx family FGW37_RS08435 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FGW37_RS08440 ENOG4108176 endoribonuclease L-psp FGW37_RS08445 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FGW37_RS08450 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FGW37_RS08460 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FGW37_RS08465 ENOG4105CIH Imidazole acetol-phosphate transaminase FGW37_RS08470 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FGW37_RS08480 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FGW37_RS08485 ENOG4108Z66 YbaK ebsC protein FGW37_RS08515 ENOG4105C0B DNA polymerase III (alpha subunit) FGW37_RS08575 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FGW37_RS08585 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FGW37_RS08590 ENOG4107VQS DivIVA family FGW37_RS08600 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FGW37_RS08605 ENOG4105DFA alanine racemase domain protein FGW37_RS08610 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FGW37_RS08615 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FGW37_RS08620 ENOG4105ME9 cell division protein FtsQ FGW37_RS08625 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FGW37_RS08635 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FGW37_RS08640 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FGW37_RS08650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FGW37_RS08655 ENOG4105CJN penicillin-binding protein FGW37_RS08665 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FGW37_RS08675 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FGW37_RS08700 ENOG4107Z3H Transcriptional regulator, TetR family FGW37_RS08705 ENOG4105EWK phytoene FGW37_RS08720 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FGW37_RS08745 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FGW37_RS08755 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FGW37_RS08765 ENOG4108UQY Iron-storage protein FGW37_RS08775 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FGW37_RS08790 ENOG4105CTQ phosphohexokinase FGW37_RS08795 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS08825 ENOG4105DKQ ROK family FGW37_RS08835 ENOG4105D0U Arsenite-activated ATPase (ArsA) FGW37_RS08870 ENOG4105K4H Nlp p60 protein FGW37_RS08900 ENOG4105C9B Cysteine desulfurase FGW37_RS08905 ENOG4108I0Q anthranilate phosphoribosyltransferase FGW37_RS08910 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FGW37_RS08915 ENOG4107EUI c reductase, iron-sulfur FGW37_RS08920 ENOG4107UDY cytochrome C FGW37_RS08925 ENOG4105CCU oxidase (Subunit III) FGW37_RS08935 ENOG4107UBC ErfK ybiS ycfS ynhG family protein FGW37_RS08940 ENOG4105MCD Part of cytochrome c oxidase, its function is FGW37_RS08945 ENOG4105BZ9 Cytochrome C oxidase, subunit I FGW37_RS08950 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FGW37_RS08960 ENOG4107T4Z adenosine kinase FGW37_RS08980 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FGW37_RS08985 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS08990 ENOG4108YZT Adenosylcobinamide kinase FGW37_RS09000 ENOG4105C0H protease FGW37_RS09025 ENOG4105BZU Histidine kinase FGW37_RS09030 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FGW37_RS09035 ENOG4105CRK lysyL-tRNA synthetase FGW37_RS09050 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FGW37_RS09055 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FGW37_RS09080 ENOG4105DTD Dehydrogenase FGW37_RS09095 ENOG4105ECP epimerase FGW37_RS09110 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FGW37_RS09115 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FGW37_RS09145 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FGW37_RS09180 ENOG4107ZVI PhiRv2 prophage protein FGW37_RS09195 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FGW37_RS09215 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FGW37_RS09225 ENOG4105BZP glycoside hydrolase 15-related FGW37_RS09230 ENOG4105CHR reductase FGW37_RS09235 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FGW37_RS09240 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FGW37_RS09250 ENOG4107NHD transcriptional regulator FGW37_RS09260 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS09270 ENOG4105M2Z protein tyrosine serine phosphatase FGW37_RS09300 ENOG4105D56 permease protein FGW37_RS09305 ENOG4105EG2 ABC transporter, permease FGW37_RS09310 ENOG4105CG3 alpha amylase, catalytic region FGW37_RS09315 ENOG4105ETE Transcriptional regulator (LacI family FGW37_RS09325 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FGW37_RS09330 ENOG4105C5F glutamine synthetase FGW37_RS09335 ENOG4106HB6 Alpha beta hydrolase FGW37_RS09340 ENOG4105E5D amino acid FGW37_RS09350 ENOG4107R16 Multicopper oxidase FGW37_RS09355 ENOG4105C4K Nad synthetase FGW37_RS09400 ENOG4107XZ0 Peptidase M50 FGW37_RS09420 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FGW37_RS09425 ENOG4105C57 major facilitator superfamily FGW37_RS09430 ENOG4108JGH Tetr family transcriptional regulator FGW37_RS09440 ENOG4105F27 Major Facilitator FGW37_RS09445 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FGW37_RS09450 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FGW37_RS09455 ENOG4105WBV Transcriptional regulator FGW37_RS09515 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FGW37_RS09520 ENOG4105EHG Permease protein FGW37_RS09525 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS09535 ENOG4105DBE peroxidase FGW37_RS09545 ENOG4106A0S FGW37_RS09565 ENOG4105CIK Amidinotransferase FGW37_RS09575 ENOG4105C2C drug resistance transporter, Bcr CflA FGW37_RS09580 ENOG4105DGI Alkaline phosphatase FGW37_RS09595 ENOG4108UHU Aldolase FGW37_RS09600 ENOG4107XFJ UPF0246 protein FGW37_RS09605 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FGW37_RS09620 ENOG4105BZU Histidine kinase FGW37_RS09635 ENOG4105CHR reductase FGW37_RS09650 ENOG4108MES Periplasmic binding protein FGW37_RS09655 ENOG4105EGD dinuclear metal center protein, YbgI family FGW37_RS09685 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase FGW37_RS09695 ENOG4105DYW oxidoreductase FGW37_RS09725 ENOG4107QVI Methyltransferase, type 11 FGW37_RS09735 ENOG4108SGK Tetr family transcriptional regulator FGW37_RS09760 ENOG4105CJA serine threonine protein kinase FGW37_RS09790 ENOG4105BZ1 (ABC) transporter FGW37_RS09840 ENOG4105DJ4 phosphatidylserine decarboxylase FGW37_RS09845 ENOG4105F2C Acetyl-CoA acetyltransferase FGW37_RS09850 ENOG4106A3M Cytochrome p-450 FGW37_RS09890 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FGW37_RS09930 ENOG4105S7M extracellular small neutral protease FGW37_RS09935 ENOG4108KXM LysR family Transcriptional regulator FGW37_RS09980 ENOG4105DAX Pfam:DUF2983 FGW37_RS10025 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FGW37_RS10055 ENOG4105BZU Histidine kinase FGW37_RS10060 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS10065 ENOG4105CPC Aldo Keto reductase FGW37_RS10070 ENOG4105VUF Transcriptional regulator FGW37_RS10095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FGW37_RS10100 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FGW37_RS10105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FGW37_RS10135 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FGW37_RS10140 ENOG4105EXN Sulfate transport protein CysZ FGW37_RS10150 ENOG4105NGS secreted protein FGW37_RS10155 ENOG4105KT7 mgtC SapB transporter FGW37_RS10175 ENOG4105E2Y ABC, transporter FGW37_RS10195 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FGW37_RS10200 ENOG41080RH Thioredoxin FGW37_RS10235 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FGW37_RS10245 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FGW37_RS10250 ENOG4108UB4 uncharacterized protein ygjQ FGW37_RS10255 ENOG4105CR4 methylisocitrate lyase FGW37_RS10280 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FGW37_RS10290 ENOG4105C0X amino acid FGW37_RS10305 ENOG4105DRS transport system, permease FGW37_RS10315 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FGW37_RS10345 ENOG4108FN7 Aldo keto reductase FGW37_RS10355 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS10370 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FGW37_RS10375 ENOG4105DSE periplasmic solute binding protein FGW37_RS10380 ENOG4105FDK ABC transporter FGW37_RS10395 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FGW37_RS10400 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FGW37_RS10420 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FGW37_RS10425 ENOG4105D4Y metalloprotease FGW37_RS10435 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FGW37_RS10470 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FGW37_RS10485 ENOG4105F8D glycoside hydrolase family 4 FGW37_RS10490 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FGW37_RS10495 ENOG4107YU2 histidine triad (hIT) protein FGW37_RS10505 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FGW37_RS10525 ENOG4105CKK Glycosyl transferase, family 2 FGW37_RS10545 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FGW37_RS10580 ENOG4107QWG 2-Nitropropane dioxygenase FGW37_RS10585 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FGW37_RS10590 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FGW37_RS10615 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FGW37_RS10620 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FGW37_RS10640 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FGW37_RS10650 ENOG4105EPR degv family FGW37_RS10660 ENOG4105C8T Leucyl-tRNA synthetase FGW37_RS10695 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FGW37_RS10700 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FGW37_RS10710 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FGW37_RS10725 ENOG4105D0M Protease HtpX homolog FGW37_RS10740 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FGW37_RS10750 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FGW37_RS10760 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FGW37_RS10765 ENOG4105K46 50S ribosomal protein l27 FGW37_RS10770 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FGW37_RS10775 ENOG4105C03 ribonuclease FGW37_RS10790 ENOG4107DKM chad domain containing protein FGW37_RS10795 ENOG4105CNI cell division protein FtsW FGW37_RS10800 ENOG4105CJN penicillin-binding protein FGW37_RS10815 ENOG4105DFF Rod shape-determining protein mreb FGW37_RS10820 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FGW37_RS10830 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FGW37_RS10845 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FGW37_RS10860 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FGW37_RS10910 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FGW37_RS10915 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FGW37_RS10920 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FGW37_RS10925 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FGW37_RS10945 ENOG4108TGC Acyltransferase FGW37_RS10975 ENOG4105C85 amino acid FGW37_RS10985 ENOG4105C85 amino acid FGW37_RS10990 ENOG4105C85 amino acid FGW37_RS10995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FGW37_RS11005 ENOG4105MC2 DSBA oxidoreductase FGW37_RS11075 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 FGW37_RS11085 ENOG4105D8X mechanosensitive ion channel FGW37_RS11095 ENOG4105E2R ROK family FGW37_RS11100 ENOG4105F8D glycoside hydrolase family 4 FGW37_RS11125 ENOG4105CT1 (ABC) transporter FGW37_RS11155 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FGW37_RS11185 ENOG4105VHU single-stranded DNA-binding protein FGW37_RS11235 ENOG4107QJE Chromosome Partitioning Protein FGW37_RS11245 ENOG4107YCR Transcriptional regulator, ARSR family FGW37_RS11275 ENOG4105KJJ Uncharacterized ACR, COG1993 FGW37_RS11285 ENOG4105C5Q Transcriptional regulator FGW37_RS11300 ENOG4105E33 succinate dehydrogenase FGW37_RS11320 ENOG4105W1N transcriptional regulator FGW37_RS11330 ENOG4105C26 Dehydrogenase FGW37_RS11335 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FGW37_RS11340 ENOG4105DH8 myo-inositol catabolism FGW37_RS11350 ENOG4105EDK PfkB domain protein FGW37_RS11360 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FGW37_RS11365 ENOG4106448 streptomycin biosynthesis protein strI FGW37_RS11385 ENOG4105C7H Helicase, RecD TraA family FGW37_RS11390 ENOG4108594 Permease of the drug metabolite transporter FGW37_RS11430 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FGW37_RS11440 ENOG4108XFF FGW37_RS11450 ENOG4105C29 acyl-CoA thioesterase FGW37_RS11465 ENOG4107QX3 carboxylase FGW37_RS11480 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS11485 ENOG4105E2D ec 3.2.1.52 FGW37_RS11500 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FGW37_RS11515 ENOG4105ECQ AraC Family Transcriptional Regulator FGW37_RS11520 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FGW37_RS11565 ENOG4105CVJ phosphoglycerate mutase FGW37_RS11610 ENOG4105BZU Histidine kinase FGW37_RS11615 ENOG4105DEN Luciferase family FGW37_RS11635 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FGW37_RS11640 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FGW37_RS11645 ENOG4108M1A Chitin-binding protein FGW37_RS11655 ENOG4105K4H Nlp p60 protein FGW37_RS11675 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FGW37_RS11715 ENOG4105D9R oxidoreductase FGW37_RS11760 ENOG4105E1V na solute symporter FGW37_RS11770 ENOG4106BRA Membrane FGW37_RS11785 ENOG4105BZ4 penicillin-binding protein FGW37_RS11795 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FGW37_RS11810 ENOG4108FKE two-component system sensor kinase FGW37_RS11820 ENOG4105CSH Transporter FGW37_RS11830 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FGW37_RS11840 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FGW37_RS11860 ENOG4108RQ5 Beta-lactamase domain-containing protein FGW37_RS11880 ENOG4105C85 amino acid FGW37_RS11890 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FGW37_RS11900 ENOG4108RWI nicotinamidase FGW37_RS11930 ENOG4105KF0 sporulation and cell division protein, SsgA FGW37_RS11935 ENOG4105CQB FAD linked oxidase domain protein FGW37_RS11940 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FGW37_RS11950 ENOG4105E90 ABC transporter FGW37_RS11955 ENOG4108IJ8 ABC transporter FGW37_RS11960 ENOG4105E90 ABC transporter FGW37_RS11985 ENOG4105C0R drug resistance transporter emrb qaca subfamily FGW37_RS11990 ENOG4107ZR7 Membrane FGW37_RS12000 ENOG4105DND Transcriptional regulator FGW37_RS12020 ENOG4105EMU Dehydrogenase FGW37_RS12025 ENOG4107RSM transcriptional regulator FGW37_RS12085 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FGW37_RS12100 ENOG4105E2D ec 3.2.1.52 FGW37_RS12125 ENOG4105F27 Major Facilitator FGW37_RS12135 ENOG4108UJU UPF0301 protein FGW37_RS12140 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FGW37_RS12145 ENOG4108426 dNA-binding protein FGW37_RS12155 ENOG4105EEM helicase FGW37_RS12180 ENOG4106NZI LysR family Transcriptional regulator FGW37_RS12200 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FGW37_RS12205 ENOG4105CN1 protease FGW37_RS12210 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) FGW37_RS12215 ENOG4105CAK Cell division ATP-binding protein ftsE FGW37_RS12230 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FGW37_RS12235 ENOG4108QVN serine threonine protein kinase FGW37_RS12240 ENOG4108UGD Serine Threonine protein kinase FGW37_RS12265 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FGW37_RS12285 ENOG4107SJB teichoic acid biosynthesis FGW37_RS12320 ENOG4105C7I Dehydrogenase FGW37_RS12340 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FGW37_RS12350 ENOG4105T0Z Conserved Protein FGW37_RS12355 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS12360 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FGW37_RS12370 ENOG4105G3P Lipoprotein lpqB FGW37_RS12375 ENOG4105BZU Histidine kinase FGW37_RS12380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FGW37_RS12385 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FGW37_RS12415 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FGW37_RS12420 ENOG4105DM4 PTS System FGW37_RS12430 ENOG4105EIP mannose-6-phosphate isomerase FGW37_RS12440 ENOG4105W49 UPF0434 protein FGW37_RS12445 ENOG4107QKV phosphomannomutase FGW37_RS12465 ENOG4107RGC Glycosyl transferase, family 2 FGW37_RS12470 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FGW37_RS12485 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) FGW37_RS12495 ENOG4107V9E glucose-1-phosphate thymidylyltransferase FGW37_RS12510 ENOG4108KGH TRANSCRIPTIONal FGW37_RS12515 ENOG4107TB5 TRANSCRIPTIONal FGW37_RS12520 ENOG4107TB5 TRANSCRIPTIONal FGW37_RS12530 ENOG4108KGH TRANSCRIPTIONal FGW37_RS12535 ENOG4108S4H thioesterase Superfamily protein FGW37_RS12540 ENOG4108KGH TRANSCRIPTIONal FGW37_RS12580 ENOG41065SU Two-component system sensor kinase FGW37_RS12585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FGW37_RS12590 ENOG4105DUX Transporter FGW37_RS12620 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FGW37_RS12625 ENOG4105CGP Urocanate hydratase FGW37_RS12640 ENOG4105CI2 imidazolone-5-propionate hydrolase FGW37_RS12645 ENOG4107S5I aldo keto reductase FGW37_RS12675 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS12695 ENOG4105CHU acetyl-coa acetyltransferase FGW37_RS12725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FGW37_RS12730 ENOG4107RBB ABC transporter, permease FGW37_RS12735 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FGW37_RS12740 ENOG4105CEP NADH dehydrogenase FGW37_RS12760 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FGW37_RS12775 ENOG4106A3M Cytochrome p-450 FGW37_RS12795 ENOG4105D9P serine threonine protein kinase FGW37_RS12840 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FGW37_RS12845 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FGW37_RS12885 ENOG4105BZU Histidine kinase FGW37_RS12895 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FGW37_RS12900 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FGW37_RS12905 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FGW37_RS12910 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FGW37_RS12925 ENOG4105C0R drug resistance transporter emrb qaca subfamily FGW37_RS12935 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FGW37_RS12945 ENOG4108RZE Tetr family transcriptional regulator FGW37_RS12950 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FGW37_RS12955 ENOG4108ZT1 Transcriptional regulator FGW37_RS12960 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS12965 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FGW37_RS12990 ENOG4105C5H ABC transporter FGW37_RS13020 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FGW37_RS13025 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FGW37_RS13035 ENOG4105F8V Hydrolase, tatD family FGW37_RS13085 ENOG4108JJB ABC transporter FGW37_RS13095 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FGW37_RS13120 ENOG4105EYF MMPL domain protein FGW37_RS13145 ENOG4108R85 Short chain dehydrogenase FGW37_RS13150 ENOG4105F95 Monooxygenase FGW37_RS13175 ENOG4108FKE two-component system sensor kinase FGW37_RS13195 ENOG4105D9U N-acetyltransferase FGW37_RS13200 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FGW37_RS13205 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FGW37_RS13215 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FGW37_RS13220 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FGW37_RS13245 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FGW37_RS13250 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FGW37_RS13295 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FGW37_RS13320 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FGW37_RS13345 ENOG4105EJ2 Transcriptional regulator FGW37_RS13365 ENOG4106A3M Cytochrome p-450 FGW37_RS13370 ENOG4106A3M Cytochrome p-450 FGW37_RS13380 ENOG4105C9U ATP-dependent DNA helicase RecQ FGW37_RS13410 ENOG4105EPJ extracellular solute-binding protein family 1 FGW37_RS13420 ENOG4105DZ1 carboxypeptidase FGW37_RS13440 ENOG41065RQ ADP-ribosylation crystallin J1 FGW37_RS13450 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FGW37_RS13485 ENOG4107S9F NmrA family FGW37_RS13495 ENOG4108YYC ycei family FGW37_RS13500 ENOG4105FQP Beta-lactamase FGW37_RS13525 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FGW37_RS13535 ENOG4105F0K SARP family transcriptional regulator FGW37_RS13555 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS13575 ENOG4108762 serine threonine protein kinase FGW37_RS13580 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FGW37_RS13590 ENOG4105D2B acyl-CoA dehydrogenase FGW37_RS13600 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FGW37_RS13615 ENOG4105CGU Enoyl-CoA hydratase FGW37_RS13620 ENOG4105MXW flavin reductase domain protein, FMN-binding FGW37_RS13635 ENOG4105ECQ AraC Family Transcriptional Regulator FGW37_RS13650 ENOG4105CC9 acyl-Coa dehydrogenase FGW37_RS13670 ENOG4105D2B acyl-CoA dehydrogenase FGW37_RS13675 ENOG4105CC9 acyl-Coa dehydrogenase FGW37_RS13705 ENOG4107QQG Dehydrogenase FGW37_RS13710 ENOG4105DFF Rod shape-determining protein mreb FGW37_RS13720 ENOG4107QVP Dehydrogenase FGW37_RS13730 ENOG4108MMM RNA Polymerase FGW37_RS13735 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS13740 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FGW37_RS13745 ENOG4105DND Transcriptional regulator FGW37_RS13755 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FGW37_RS13770 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FGW37_RS13805 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FGW37_RS13830 ENOG4108097 ATP-binding protein FGW37_RS13840 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FGW37_RS13885 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FGW37_RS13895 ENOG4105CS9 pantothenic acid kinase FGW37_RS13905 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FGW37_RS13910 ENOG4108UJD 30S ribosomal protein S9 FGW37_RS13915 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FGW37_RS13920 ENOG4105C5H ABC transporter FGW37_RS13935 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FGW37_RS13940 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FGW37_RS13945 ENOG4108ZT0 50S ribosomal protein l17 FGW37_RS13955 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FGW37_RS13960 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FGW37_RS13970 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FGW37_RS13980 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FGW37_RS13990 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FGW37_RS14000 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FGW37_RS14005 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FGW37_RS14010 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FGW37_RS14015 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FGW37_RS14020 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FGW37_RS14025 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FGW37_RS14030 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FGW37_RS14035 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FGW37_RS14040 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FGW37_RS14045 ENOG41082SA 50s ribosomal protein l29 FGW37_RS14050 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FGW37_RS14055 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FGW37_RS14060 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FGW37_RS14065 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FGW37_RS14070 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FGW37_RS14075 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FGW37_RS14080 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FGW37_RS14085 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FGW37_RS14090 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FGW37_RS14105 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FGW37_RS14110 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FGW37_RS14115 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FGW37_RS14120 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FGW37_RS14125 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FGW37_RS14130 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FGW37_RS14145 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FGW37_RS14150 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FGW37_RS14155 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FGW37_RS14180 ENOG4107R4N Cell wall formation (By similarity) FGW37_RS14200 ENOG410900P UPF0336 protein FGW37_RS14205 ENOG4105WDJ 50S ribosomal protein L33 FGW37_RS14235 ENOG4108VPT UPF0234 protein FGW37_RS14240 ENOG410901E Membrane FGW37_RS14250 ENOG4105D0M Protease HtpX homolog FGW37_RS14255 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14260 ENOG4105C8S subunit m FGW37_RS14265 ENOG4105D65 subunit l FGW37_RS14270 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14280 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14285 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FGW37_RS14290 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14295 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14300 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FGW37_RS14320 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FGW37_RS14325 ENOG4105DQU oxidoreductase, subunit beta FGW37_RS14330 ENOG4105C0X amino acid FGW37_RS14340 ENOG4105IIU Aminopeptidase FGW37_RS14365 ENOG4105CAY ferredoxin--nadp reductase FGW37_RS14390 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14400 ENOG4105D65 subunit l FGW37_RS14405 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14410 ENOG41087XN oxidoreductase FGW37_RS14415 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14420 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FGW37_RS14425 ENOG4108IEH NADH dehydrogenase subunit g FGW37_RS14430 ENOG4107QIZ NADH dehydrogenase FGW37_RS14440 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14445 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FGW37_RS14450 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS14485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FGW37_RS14495 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FGW37_RS14500 ENOG4108762 serine threonine protein kinase FGW37_RS14505 ENOG4108SEA Esterase FGW37_RS14510 ENOG4105EV6 Pfam:DUF178 FGW37_RS14515 ENOG4105VEQ Cold shock protein FGW37_RS14535 ENOG4108IG5 Transcriptional regulator FGW37_RS14540 ENOG4105CK2 sodium dicarboxylate symporter FGW37_RS14550 ENOG4105DVY radical SAM domain protein FGW37_RS14565 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FGW37_RS14575 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FGW37_RS14585 ENOG4105HSS phospholipase C FGW37_RS14595 ENOG4105CRE cytochrome C FGW37_RS14600 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) FGW37_RS14605 ENOG4107QIV Cytochrome c biogenesis protein FGW37_RS14610 ENOG4107ZT5 Thiol disulfide interchange protein FGW37_RS14620 ENOG4108RH7 phosphoglycerate mutase FGW37_RS14625 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FGW37_RS14635 ENOG4105KK4 UPF0060 membrane protein FGW37_RS14655 ENOG4105E0Y RtcB Protein FGW37_RS14670 ENOG4105DK7 lysyl-tRNA synthetase FGW37_RS14675 ENOG4105C75 arginyL-tRNA synthetase FGW37_RS14685 ENOG4105D52 delta-aminolevulinic acid dehydratase FGW37_RS14690 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FGW37_RS14695 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FGW37_RS14700 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FGW37_RS14705 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FGW37_RS14755 ENOG4105DGU Histone deacetylase FGW37_RS14760 ENOG4107YBY Hydrolase FGW37_RS14780 ENOG4105C31 Tryptophanyl-tRNA synthetase FGW37_RS14785 ENOG4105II7 pyrroline-5-carboxylate reductase FGW37_RS14790 ENOG4105CHH sulfate transporter FGW37_RS14845 ENOG4105ESP cell wall surface anchor family protein FGW37_RS14860 ENOG4105D5U fad dependent oxidoreductase FGW37_RS14865 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FGW37_RS14885 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FGW37_RS14940 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FGW37_RS14950 ENOG4105CPC Aldo Keto reductase FGW37_RS14965 ENOG4105C1J atp-dependent rna helicase FGW37_RS14970 ENOG4105VEQ Cold shock protein FGW37_RS14980 ENOG4105EUZ Beta-lactamase domain protein FGW37_RS15020 ENOG4105CQ7 ATP-dependent helicase FGW37_RS15040 ENOG4108TAC FGW37_RS15055 ENOG4105CXB phosphoribosylaminoimidazole synthetase FGW37_RS15080 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FGW37_RS15085 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FGW37_RS15090 ENOG410839H phosphoribosylformylglycinamidine synthase FGW37_RS15130 ENOG4105BZU Histidine kinase FGW37_RS15135 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS15145 ENOG41062D9 Histidine kinase FGW37_RS15150 ENOG4105ETX regulatoR FGW37_RS15155 ENOG4105C8V SAICAR synthetase FGW37_RS15170 ENOG4105C12 Phosphoribosylglycinamide synthetase FGW37_RS15185 ENOG4108WYP Transcriptional regulator FGW37_RS15190 ENOG4108JPW Aminotransferase FGW37_RS15195 ENOG4105VEQ Cold shock protein FGW37_RS15200 ENOG4108762 serine threonine protein kinase FGW37_RS15205 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FGW37_RS15215 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS15220 ENOG4105BZU Histidine kinase FGW37_RS15230 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FGW37_RS15235 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FGW37_RS15255 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FGW37_RS15285 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FGW37_RS15310 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FGW37_RS15365 ENOG4105DXX methyltransferase FGW37_RS15405 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS15425 ENOG4105KNI merR family transcriptional Regulator FGW37_RS15430 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FGW37_RS15435 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FGW37_RS15440 ENOG4105CFG Acts as a chaperone (By similarity) FGW37_RS15450 ENOG4105DF6 Fe-S oxidoreductase FGW37_RS15470 ENOG4105DHP deoxycytidine triphosphate deaminase FGW37_RS15485 ENOG4105D9P serine threonine protein kinase FGW37_RS15515 ENOG4105C0R drug resistance transporter emrb qaca subfamily FGW37_RS15600 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FGW37_RS15620 ENOG4105CHR reductase FGW37_RS15645 ENOG4108IG5 Transcriptional regulator FGW37_RS15650 ENOG41064MX Tetr family transcriptional regulator FGW37_RS15655 ENOG4108SEA Esterase FGW37_RS15675 ENOG4106F60 Histidine kinase FGW37_RS15680 ENOG4105F44 Two component transcriptional regulator, winged helix family FGW37_RS15730 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FGW37_RS15745 ENOG4105C9M aspartyl-trna synthetase FGW37_RS15755 ENOG4105EUB pirin domain protein FGW37_RS15770 ENOG4105CSU acyl-Coa dehydrogenase FGW37_RS15775 ENOG4105DFM M18 family aminopeptidase FGW37_RS15805 ENOG4105DJB Major Facilitator Superfamily FGW37_RS15820 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FGW37_RS15825 ENOG4105CPP Dehydrogenase, E1 component FGW37_RS15855 ENOG4107QPV Serine Threonine protein kinase FGW37_RS15860 ENOG4108VC7 Protein of unknown function (DUF2587) FGW37_RS15870 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FGW37_RS15880 ENOG4105CVM Molybdenum cofactor synthesis domain protein FGW37_RS15890 ENOG4107QSN dihydrolipoamide acetyltransferase FGW37_RS15910 ENOG4108IG5 Transcriptional regulator FGW37_RS15915 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FGW37_RS15940 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FGW37_RS15945 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FGW37_RS15950 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FGW37_RS15955 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FGW37_RS15960 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FGW37_RS15970 ENOG41082J7 Rhodanese domain protein FGW37_RS16000 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FGW37_RS16010 ENOG4105C3R Methionine synthase FGW37_RS16015 ENOG4107T4Z adenosine kinase FGW37_RS16020 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FGW37_RS16035 ENOG4105MC2 DSBA oxidoreductase FGW37_RS16050 ENOG4107ZXU DSBA oxidoreductase FGW37_RS16055 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FGW37_RS16060 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FGW37_RS16070 ENOG4105MXW flavin reductase domain protein, FMN-binding FGW37_RS16085 ENOG4105CZS beta-ketoacyl synthase FGW37_RS16115 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) FGW37_RS16165 ENOG4107V9E glucose-1-phosphate thymidylyltransferase FGW37_RS16195 ENOG4105TV9 FHA Domain-Containing protein FGW37_RS16200 ENOG4105HZM Fha domain containing protein FGW37_RS16215 ENOG4105CJN penicillin-binding protein FGW37_RS16225 ENOG4108RN7 integral membrane protein FGW37_RS16230 ENOG4108U4N (sortase) family FGW37_RS16245 ENOG4108U4N (sortase) family FGW37_RS16255 ENOG4105ZJT Cell division protein CrgA FGW37_RS16300 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS16315 ENOG4107WY9 o-methyltransferase FGW37_RS16320 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS16325 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FGW37_RS16330 ENOG4107T4Z adenosine kinase FGW37_RS16355 ENOG4108UGD Serine Threonine protein kinase FGW37_RS16375 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FGW37_RS16385 ENOG4105K7N UPF0232 protein FGW37_RS16390 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FGW37_RS16395 ENOG4108J5G 6-phosphogluconate dehydrogenase FGW37_RS16400 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FGW37_RS16410 ENOG41084CH 50S ribosomal protein l34 FGW37_RS16415 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FGW37_RS16420 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FGW37_RS16425 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FGW37_RS16435 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FGW37_RS16440 ENOG4107QJE Chromosome Partitioning Protein FGW37_RS16455 ENOG4105K63 Thioredoxin FGW37_RS16460 ENOG4105C3M thioredoxin reductase FGW37_RS16475 ENOG4105D9P serine threonine protein kinase FGW37_RS16490 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FGW37_RS16500 ENOG4105CZA synthase FGW37_RS16510 ENOG4105BZ4 penicillin-binding protein FGW37_RS16535 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) FGW37_RS16540 ENOG4107YH6 single-stranded DNA-binding protein FGW37_RS16545 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FGW37_RS16550 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FGW37_RS16560 ENOG4105CDU Replicative dna helicase FGW37_RS16565 ENOG4105CPC Aldo Keto reductase FGW37_RS16580 ENOG4107STF Involved in phosphonate degradation (By similarity) FGW37_RS16600 ENOG4105F27 Major Facilitator FGW37_RS16630 ENOG4105C28 cystathionine FGW37_RS16635 ENOG41082T9 Membrane FGW37_RS16640 ENOG4106048 Cupin 2, conserved barrel domain protein FGW37_RS16650 ENOG4105KF0 sporulation and cell division protein, SsgA FGW37_RS16655 ENOG4105DZ6 Band 7 protein FGW37_RS16670 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FGW37_RS16685 ENOG4107P2S Transcriptional regulator FGW37_RS16690 ENOG4105CIH Imidazole acetol-phosphate transaminase FGW37_RS16695 ENOG4105C4M (Ubiquinol oxidase) subunit I FGW37_RS16700 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FGW37_RS16705 ENOG4108JJ9 ABC, transporter FGW37_RS16715 ENOG4105DR5 peptidase FGW37_RS16720 ENOG410667J hydrolase FGW37_RS16730 ENOG4105D0M Protease HtpX homolog FGW37_RS16740 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) FGW37_RS16755 ENOG4107SWG transcriptional regulator MERR family FGW37_RS16775 ENOG4105DA5 (ABC) transporter FGW37_RS16800 ENOG4105DJ2 Major Facilitator Superfamily FGW37_RS16815 ENOG410667J hydrolase FGW37_RS16820 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FGW37_RS16830 ENOG4105DBE peroxidase FGW37_RS16835 ENOG4105JDN Copper resistance protein FGW37_RS16845 ENOG4108ZX6 Electron transport protein SCO1 SenC FGW37_RS16865 ENOG4108ZHR arsR family transcriptional regulator FGW37_RS16885 ENOG4107T6F Xaa-Pro aminopeptidase FGW37_RS16905 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FGW37_RS16920 ENOG4105C0H protease FGW37_RS16955 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FGW37_RS16960 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FGW37_RS16995 ENOG4105C57 major facilitator superfamily FGW37_RS17025 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FGW37_RS17065 ENOG4105NAF rna polymerase sigma factor FGW37_RS17070 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS17085 ENOG4108UXN response regulator FGW37_RS17110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FGW37_RS17130 ENOG4105C57 major facilitator superfamily FGW37_RS17145 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FGW37_RS17160 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FGW37_RS17170 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein FGW37_RS17245 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FGW37_RS17260 ENOG4108Z6B deaminase FGW37_RS17280 ENOG4105F27 Major Facilitator FGW37_RS17285 ENOG4107SET aldo keto reductase FGW37_RS17310 ENOG4105YKW FGW37_RS17320 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FGW37_RS17330 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FGW37_RS17345 ENOG4105E82 cytochrome subunit of dehydrogenase FGW37_RS17360 ENOG4105C6T cysteine synthase FGW37_RS17365 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FGW37_RS17375 ENOG4105D7W serine acetyltransferase FGW37_RS17385 ENOG4105E8G Major facilitator Superfamily FGW37_RS17400 ENOG41086D8 Transcriptional regulator FGW37_RS17420 ENOG4107NHD transcriptional regulator FGW37_RS17425 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FGW37_RS17430 ENOG4108IFG nitrite reductase, (NAD(P)H) FGW37_RS17435 ENOG4107QZF nitrite reductase NADPH large subunit FGW37_RS17440 ENOG4105DQQ Major facilitator superfamily MFS_1 FGW37_RS17560 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FGW37_RS17565 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FGW37_RS17580 ENOG4105CFH Aspartokinase FGW37_RS17590 ENOG4105NAF rna polymerase sigma factor FGW37_RS17620 ENOG4105C6T cysteine synthase FGW37_RS17625 ENOG4105CIF Ornithine Cyclodeaminase FGW37_RS17665 ENOG4108JQC penicillin-binding protein 1A FGW37_RS17715 ENOG4105P8F nudix hydrolase FGW37_RS17730 ENOG4105D74 hydrolase FGW37_RS17740 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FGW37_RS17745 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FGW37_RS17750 ENOG4107B2H carbonic anhydrase FGW37_RS17810 ENOG4108I5C dEAD DEAH box helicase FGW37_RS17815 ENOG4105WN5 stage II sporulation protein FGW37_RS17825 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for FGW37_RS17835 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FGW37_RS17845 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FGW37_RS17850 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FGW37_RS17855 ENOG4105C6E dna polymerase iii FGW37_RS17890 ENOG4105DEF Extracellular solute-binding protein, family 5 FGW37_RS17895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FGW37_RS17905 ENOG4108JQ6 ABC transporter FGW37_RS17910 ENOG4107RSM transcriptional regulator FGW37_RS17935 ENOG4106A3M Cytochrome p-450 FGW37_RS17940 ENOG41065KQ synthase FGW37_RS17955 ENOG4105C2M dna polymerase I FGW37_RS17980 ENOG4105U5Y Transcriptional regulator FGW37_RS18020 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FGW37_RS18025 ENOG4105KDC 50s ribosomal protein l28 FGW37_RS18035 ENOG4105NRA 50s ribosomal protein l31 type b FGW37_RS18045 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FGW37_RS18065 ENOG4105C26 Dehydrogenase FGW37_RS18100 ENOG4107TXC Transcriptional regulator FGW37_RS18105 ENOG41082VC UPF0145 protein FGW37_RS18120 ENOG4105F0N pyrophosphate phospho-hydrolase FGW37_RS18135 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FGW37_RS18140 ENOG4108UGV hypoxanthine phosphoribosyltransferase FGW37_RS18150 ENOG4105EUJ GTP cyclohydrolase i FGW37_RS18160 ENOG4105CRK lysyL-tRNA synthetase FGW37_RS18180 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FGW37_RS18190 ENOG4108IJ8 ABC transporter FGW37_RS18195 ENOG4105E90 ABC transporter FGW37_RS18200 ENOG4105E90 ABC transporter FGW37_RS18215 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS18230 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS18235 ENOG41082SX arsR family transcriptional regulator FGW37_RS18250 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FGW37_RS18255 ENOG4108IYU L-aspartate oxidase FGW37_RS18265 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FGW37_RS18315 ENOG4105E4C Lytic transglycosylase catalytic FGW37_RS18320 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FGW37_RS18325 ENOG4108FKE two-component system sensor kinase FGW37_RS18330 ENOG4108PYU two-component system response regulator FGW37_RS18335 ENOG41075QH Lipoprotein CseA FGW37_RS18340 ENOG4105NAF rna polymerase sigma factor FGW37_RS18350 ENOG4105BZU Histidine kinase FGW37_RS18375 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FGW37_RS18390 ENOG4108JWX FGW37_RS18395 ENOG4107R33 ppx gppa phosphatase FGW37_RS18400 ENOG4105EY0 Xylose isomerase domain protein TIM barrel FGW37_RS18410 ENOG4105C01 Dihydroxy-acid dehydratase FGW37_RS18415 ENOG4108762 serine threonine protein kinase FGW37_RS18445 ENOG4105C5I Dehydrogenase FGW37_RS18455 ENOG4105BZU Histidine kinase FGW37_RS18460 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS18470 ENOG4105CI2 imidazolone-5-propionate hydrolase FGW37_RS18505 ENOG4105D9P serine threonine protein kinase FGW37_RS18515 ENOG4105E4C Lytic transglycosylase catalytic FGW37_RS18520 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FGW37_RS18525 ENOG4105DNP FAD linked oxidase domain protein FGW37_RS18540 ENOG4105VPX protein, conserved in bacteria FGW37_RS18550 ENOG4105CJ3 phosphate transporter FGW37_RS18555 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS18570 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FGW37_RS18600 ENOG4105CPC Aldo Keto reductase FGW37_RS18610 ENOG4105GTG Isochorismatase FGW37_RS18630 ENOG4105HHS UPF0256 protein FGW37_RS18640 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FGW37_RS18645 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FGW37_RS18650 ENOG41090R7 Ferric uptake FGW37_RS18660 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS18665 ENOG4105EHG Permease protein FGW37_RS18670 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands FGW37_RS18690 ENOG4105PKJ carbohydrate binding FGW37_RS18695 ENOG4105KHC sulfurtransferase FGW37_RS18730 ENOG4107NHD transcriptional regulator FGW37_RS18735 ENOG4105ETE Transcriptional regulator (LacI family FGW37_RS18740 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS18765 ENOG4105EZE Cupin 4 family protein FGW37_RS18770 ENOG4105EZE Cupin 4 family protein FGW37_RS18775 ENOG4105C0H protease FGW37_RS18780 ENOG4105ETX regulatoR FGW37_RS18795 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FGW37_RS18815 ENOG4105CGH 5'-nucleotidase FGW37_RS18820 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FGW37_RS18830 ENOG4105EYF MMPL domain protein FGW37_RS18845 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FGW37_RS18850 ENOG4108M15 ABC transporter FGW37_RS18855 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FGW37_RS18875 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FGW37_RS18880 ENOG4108YZJ Pfam:DUF2596 FGW37_RS18885 ENOG4105E5W Transporter FGW37_RS18890 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FGW37_RS18910 ENOG4105BZU Histidine kinase FGW37_RS18925 ENOG4108VJ1 Transcriptional regulator (CarD family FGW37_RS18930 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FGW37_RS18935 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FGW37_RS18955 ENOG4105C8N cysteinyl-tRNA synthetase FGW37_RS18970 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FGW37_RS18990 ENOG4105EYF MMPL domain protein FGW37_RS19020 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS19060 ENOG4105EWC Purine nucleoside phosphorylase FGW37_RS19080 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FGW37_RS19090 ENOG4105BZU Histidine kinase FGW37_RS19105 ENOG4105D2N Aldolase FGW37_RS19110 ENOG4105DE4 1-phosphofructokinase FGW37_RS19115 ENOG4105CE4 GlcNAc 6-P deacetylase FGW37_RS19160 ENOG4105C3Q Glycosyl transferase, family 2 FGW37_RS19185 ENOG4105C5Y PTS System FGW37_RS19190 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FGW37_RS19195 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FGW37_RS19215 ENOG4106N3A copper homeostasis protein cutc FGW37_RS19220 ENOG4108RWP Major Facilitator Superfamily protein FGW37_RS19225 ENOG4105YVS arsR family transcriptional regulator FGW37_RS19230 ENOG4105EEM helicase FGW37_RS19245 ENOG4105CFI type iii restriction protein res subunit FGW37_RS19300 ENOG4108N0W Major Facilitator superfamily FGW37_RS19310 ENOG4108UIH futalosine nucleosidase FGW37_RS19315 ENOG4105E63 Pfam:DUF178 FGW37_RS19320 ENOG4105VEQ Cold shock protein FGW37_RS19335 ENOG4105DQ5 transport system permease protein FGW37_RS19340 ENOG4105TVJ transport system, permease FGW37_RS19345 ENOG4105E0A ABC, transporter FGW37_RS19350 ENOG4108MES Periplasmic binding protein FGW37_RS19360 ENOG4108YYC ycei family FGW37_RS19390 ENOG4105C7N Xanthine uracil vitamin C permease FGW37_RS19400 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FGW37_RS19420 ENOG4105XMC MarR family Transcriptional regulator FGW37_RS19435 ENOG4105CPC Aldo Keto reductase FGW37_RS19460 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FGW37_RS19465 ENOG4105CQB FAD linked oxidase domain protein FGW37_RS19475 ENOG4107QX3 carboxylase FGW37_RS19495 ENOG4105CGU Enoyl-CoA hydratase FGW37_RS19510 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FGW37_RS19520 ENOG4108SU4 UPF0309 protein FGW37_RS19530 ENOG4108XEP Alpha Beta Hydrolase Fold protein FGW37_RS19575 ENOG4105WN5 stage II sporulation protein FGW37_RS19580 ENOG4105BZU Histidine kinase FGW37_RS19585 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS19655 ENOG4108DT4 serine threonine protein kinase FGW37_RS19665 ENOG4105C26 Dehydrogenase FGW37_RS19690 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FGW37_RS19710 ENOG41069FZ L,D-transpeptidase catalytic domain FGW37_RS19730 ENOG4105D9P serine threonine protein kinase FGW37_RS19740 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS19750 ENOG4105K4H Nlp p60 protein FGW37_RS19765 ENOG4105DR5 peptidase FGW37_RS19790 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FGW37_RS19805 ENOG4105DEG Vwa containing coxe family protein FGW37_RS19810 ENOG4105CMV Succinyl-CoA synthetase subunit beta FGW37_RS19835 ENOG4105DC1 bifunctional purine biosynthesis protein purh FGW37_RS19845 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FGW37_RS19865 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FGW37_RS19895 ENOG4108IJ7 Glycine betaine FGW37_RS19900 ENOG4108HQS Glycine betaine FGW37_RS19910 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FGW37_RS19915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FGW37_RS19925 ENOG4106032 Glutathionylspermidine synthase FGW37_RS19940 ENOG4105C8Y Acetylornithine aminotransferase FGW37_RS19945 ENOG4105C31 Tryptophanyl-tRNA synthetase FGW37_RS19955 ENOG4107H3J ribonuclease FGW37_RS19970 ENOG4105DEF Extracellular solute-binding protein, family 5 FGW37_RS19980 ENOG4108Z6Z Transcriptional regulator FGW37_RS19990 ENOG4108J01 L-aspartate oxidase FGW37_RS20010 ENOG4105E2D ec 3.2.1.52 FGW37_RS20015 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FGW37_RS20025 ENOG4108MMM RNA Polymerase FGW37_RS20035 ENOG4105D5P Methylmalonyl-coA mutase FGW37_RS20100 ENOG4107YCY Transcriptional regulator FGW37_RS20105 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FGW37_RS20110 ENOG4105C6Z Gluconate FGW37_RS20140 ENOG4105K64 Glycosyl transferase, family 2 FGW37_RS20165 ENOG4107RM1 amidohydrolase FGW37_RS20170 ENOG4105DIH basic membrane FGW37_RS20175 ENOG4108JQ9 ABC transporter FGW37_RS20180 ENOG4105UIB (ABC) transporter FGW37_RS20210 ENOG4105D94 Major Facilitator Superfamily FGW37_RS20215 ENOG4107RSM transcriptional regulator FGW37_RS20225 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FGW37_RS20250 ENOG41065SU Two-component system sensor kinase FGW37_RS20255 ENOG4108KXV response regulator FGW37_RS20260 ENOG4105NAF rna polymerase sigma factor FGW37_RS20275 ENOG4105C26 Dehydrogenase FGW37_RS20280 ENOG4105C26 Dehydrogenase FGW37_RS20285 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FGW37_RS20295 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain FGW37_RS20335 ENOG4108JIK carboxylase FGW37_RS20375 ENOG4107WR6 Maf-like protein FGW37_RS20380 ENOG4105CJN penicillin-binding protein FGW37_RS20395 ENOG4105D8K carboxyl transferase FGW37_RS20405 ENOG4108QER Adenylate cyclase FGW37_RS20415 ENOG4105KDM Diguanylate cyclase with gaf sensor FGW37_RS20420 ENOG4105C84 Histidine ammonia-lyase FGW37_RS20450 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FGW37_RS20470 ENOG4108NUI synthase FGW37_RS20490 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FGW37_RS20510 ENOG4105C7B Threonine dehydratase FGW37_RS20525 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FGW37_RS20535 ENOG4105T1M mycothiol conjugate amidase mca FGW37_RS20545 ENOG4105C7Z Conserved Protein FGW37_RS20555 ENOG4105C57 major facilitator superfamily FGW37_RS20565 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FGW37_RS20595 ENOG4108FUF Transcriptional regulator, IclR family FGW37_RS20600 ENOG4105KME endoribonuclease L-psp FGW37_RS20605 ENOG4105C6Z Gluconate FGW37_RS20655 ENOG4107QMS site-determining protein FGW37_RS20685 ENOG4105BZU Histidine kinase FGW37_RS20690 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS20710 ENOG4107QKZ Ompa motb domain protein FGW37_RS20750 ENOG4105F27 Major Facilitator FGW37_RS20755 ENOG4105CPC Aldo Keto reductase FGW37_RS20760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FGW37_RS20765 ENOG4108IAB Phoh family FGW37_RS20780 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FGW37_RS20785 ENOG4105D3R alkyl hydroperoxide reductase FGW37_RS20800 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FGW37_RS20810 ENOG4105BZ4 penicillin-binding protein FGW37_RS20815 ENOG4105CH6 catalase FGW37_RS20825 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FGW37_RS20835 ENOG4105C9Q fumarate hydratase class II FGW37_RS20845 ENOG4107GFK fumarate FGW37_RS20870 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FGW37_RS20875 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FGW37_RS20880 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FGW37_RS20890 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FGW37_RS20905 ENOG4105C3G gtp-binding protein FGW37_RS20920 ENOG4107QTZ amino acid FGW37_RS20995 ENOG4105CI3 gtp-binding protein typa FGW37_RS21005 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FGW37_RS21010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS21015 ENOG4105C3U ABC transporter FGW37_RS21020 ENOG4108JQ7 (ABC) transporter FGW37_RS21030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FGW37_RS21035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS21040 ENOG4105C3U ABC transporter FGW37_RS21045 ENOG4108JQ7 (ABC) transporter FGW37_RS21050 ENOG4108JQ7 (ABC) transporter FGW37_RS21055 ENOG4105C3U ABC transporter FGW37_RS21060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FGW37_RS21065 ENOG4108J59 Extracellular solute-binding protein, family 5 FGW37_RS21070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS21085 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FGW37_RS21100 ENOG4108M15 ABC transporter FGW37_RS21110 ENOG4105BZU Histidine kinase FGW37_RS21130 ENOG4108Z4U Ferredoxin FGW37_RS21150 ENOG4107R4C succinyl-diaminopimelate desuccinylase FGW37_RS21155 ENOG4108URH decarboxylase FGW37_RS21160 ENOG4105EEI dihydropteroate synthase FGW37_RS21170 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FGW37_RS21175 ENOG4105CGU Enoyl-CoA hydratase FGW37_RS21190 ENOG4105DU6 RNA polymerase FGW37_RS21205 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FGW37_RS21215 ENOG4106178 UPF0339 protein FGW37_RS21250 ENOG4105D7N magnesium and cobalt transport protein CorA FGW37_RS21270 ENOG41081FY multiple antibiotic resistance (MarC)-related FGW37_RS21295 ENOG4105C1J atp-dependent rna helicase FGW37_RS21340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS21390 ENOG4106JDR secreted FGW37_RS21425 ENOG4105C4R Atp-dependent dna helicase FGW37_RS21430 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FGW37_RS21455 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FGW37_RS21525 ENOG41063PX domain protein FGW37_RS21535 ENOG4105DJZ UPF0182 protein FGW37_RS21570 ENOG4107TK4 histidinol-phosphate phosphatase FGW37_RS21580 ENOG4105KPY Small multidrug resistance protein FGW37_RS21590 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FGW37_RS21600 ENOG4108RAV Conserved protein FGW37_RS21610 ENOG4105EMN RNA polymerase sigma factor FGW37_RS21620 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FGW37_RS21635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FGW37_RS21645 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FGW37_RS21650 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FGW37_RS21665 ENOG4107TYG Oxidoreductase domain-containing protein FGW37_RS21670 ENOG4107B2H carbonic anhydrase FGW37_RS21675 ENOG4105CHH sulfate transporter FGW37_RS21695 ENOG4105DXI Major Facilitator superfamily FGW37_RS21700 ENOG4105FDP GntR family transcriptional regulator FGW37_RS21720 ENOG4105D17 glycoside hydrolase, family 3 domain protein FGW37_RS21725 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FGW37_RS21730 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FGW37_RS21735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FGW37_RS21740 ENOG4108IND Tetr family transcriptional regulator FGW37_RS21755 ENOG4105CBD Diacylglycerol kinase FGW37_RS21800 ENOG4105CSV Glutaminase FGW37_RS21805 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FGW37_RS21810 ENOG4105G6Z alkaline phosphatase FGW37_RS21815 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FGW37_RS21830 ENOG4105ETX regulatoR FGW37_RS21845 ENOG4107RSM transcriptional regulator FGW37_RS21850 ENOG4105F27 Major Facilitator FGW37_RS21860 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FGW37_RS21875 ENOG41082SX arsR family transcriptional regulator FGW37_RS21885 ENOG4108VEQ Superoxide dismutase FGW37_RS21910 ENOG4105CB2 alcohol dehydrogenase FGW37_RS21915 ENOG4105C6K Malic enzyme FGW37_RS21925 ENOG4105E5Q amino acid AbC transporter FGW37_RS21930 ENOG4105CDA abc transporter atp-binding protein FGW37_RS21970 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FGW37_RS21975 ENOG4105EB3 Histidine kinase FGW37_RS21980 ENOG4108PYU two-component system response regulator FGW37_RS21995 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FGW37_RS22000 ENOG4105UEI Transcriptional Regulator AraC Family FGW37_RS22005 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FGW37_RS22010 ENOG4105K56 Transcriptional regulator FGW37_RS22065 ENOG4105K4H Nlp p60 protein FGW37_RS22180 ENOG4105FDP GntR family transcriptional regulator FGW37_RS22255 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FGW37_RS22260 ENOG4105D6E homoserine dehydrogenase FGW37_RS22265 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FGW37_RS22270 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FGW37_RS22285 ENOG4105VFB Binds the 23S rRNA (By similarity) FGW37_RS22290 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FGW37_RS22295 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FGW37_RS22305 ENOG4107ZF2 Phosphatase FGW37_RS22310 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FGW37_RS22315 ENOG4105ESV Glycosyl transferase, family 4 FGW37_RS22320 ENOG4105Z3P ATP synthase FGW37_RS22330 ENOG4105ZA1 atp synthase FGW37_RS22335 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FGW37_RS22340 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FGW37_RS22345 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FGW37_RS22350 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FGW37_RS22355 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FGW37_RS22360 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FGW37_RS22375 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS22380 ENOG4105BZU Histidine kinase FGW37_RS22385 ENOG4105IIP Membrane FGW37_RS22395 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FGW37_RS22410 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) FGW37_RS22470 ENOG4105CHU acetyl-coa acetyltransferase FGW37_RS22480 ENOG4105BZ4 penicillin-binding protein FGW37_RS22520 ENOG410684T prevent-host-death family FGW37_RS22545 ENOG4105WX6 Membrane FGW37_RS22585 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FGW37_RS22590 ENOG4105C6K Malic enzyme FGW37_RS22595 ENOG4105CTQ phosphohexokinase FGW37_RS22615 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FGW37_RS22620 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FGW37_RS22625 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FGW37_RS22640 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FGW37_RS22650 ENOG4108MRH transcriptional regulatory protein FGW37_RS22655 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FGW37_RS22660 ENOG4107QJT sodium dicarboxylate symporter FGW37_RS22695 ENOG4105C57 major facilitator superfamily FGW37_RS22700 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FGW37_RS22705 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FGW37_RS22710 ENOG4105CG3 alpha amylase, catalytic region FGW37_RS22715 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FGW37_RS22720 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FGW37_RS22730 ENOG4105BZ1 (ABC) transporter FGW37_RS22735 ENOG4105BZ1 (ABC) transporter FGW37_RS22745 ENOG41069FZ L,D-transpeptidase catalytic domain FGW37_RS22785 ENOG4105EJQ L-serine dehydratase FGW37_RS22790 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FGW37_RS22795 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FGW37_RS22800 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FGW37_RS22825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS22830 ENOG4108J59 Extracellular solute-binding protein, family 5 FGW37_RS22845 ENOG4108JQ7 (ABC) transporter FGW37_RS22850 ENOG4105EN6 Membrane FGW37_RS22865 ENOG4105D29 Helix-turn-helix type 11 domain protein FGW37_RS22880 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FGW37_RS22890 ENOG4108URH decarboxylase FGW37_RS22895 ENOG4105EMU Dehydrogenase FGW37_RS22915 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FGW37_RS22920 ENOG4105BZU Histidine kinase FGW37_RS22925 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FGW37_RS22930 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FGW37_RS22940 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FGW37_RS22950 ENOG4105EYF MMPL domain protein FGW37_RS22965 ENOG4108FN7 Aldo keto reductase FGW37_RS22975 ENOG4105BZU Histidine kinase FGW37_RS22985 ENOG4108ZP8 Acetolactate synthase small subunit FGW37_RS22990 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FGW37_RS22995 ENOG4108JQ1 Dehydrogenase FGW37_RS23005 ENOG4105C57 major facilitator superfamily FGW37_RS23015 ENOG4106YKD Cytochrome p-450 FGW37_RS23035 ENOG4105C26 Dehydrogenase FGW37_RS23040 ENOG4107RIS Acyl-transferase FGW37_RS23045 ENOG4105KNE Phosphatidate cytidylyltransferase FGW37_RS23065 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FGW37_RS23070 ENOG4105CM2 brancheD-chain amino acid aminotransferase FGW37_RS23075 ENOG4105CSH Transporter FGW37_RS23080 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FGW37_RS23095 ENOG4108YYC ycei family FGW37_RS23100 ENOG4106AM8 polysaccharide lyase family 8 FGW37_RS23105 ENOG4105D8K carboxyl transferase FGW37_RS23125 ENOG4105GWZ Roadblock lc7 family protein FGW37_RS23145 ENOG4105GWZ Roadblock lc7 family protein FGW37_RS23160 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FGW37_RS23165 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FGW37_RS23215 ENOG41069M3 Transcriptional regulator FGW37_RS23220 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FGW37_RS23225 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FGW37_RS23235 ENOG4105K70 DNA-binding protein FGW37_RS23255 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FGW37_RS23260 ENOG4105CPF Cell wall formation (By similarity) FGW37_RS23280 ENOG4105DWF phosphomethylpyrimidine kinase FGW37_RS23285 ENOG4105VB9 50S ribosomal protein l28 FGW37_RS23290 ENOG4105DP4 dak2 domain fusion protein ylov FGW37_RS23300 ENOG4106H78 methyltransferase FGW37_RS23305 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FGW37_RS23320 ENOG41084BZ 50S ribosomal protein L32 FGW37_RS23325 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FGW37_RS23330 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FGW37_RS23335 ENOG4105KVH Transcriptional regulator FGW37_RS23350 ENOG4108375 Acylphosphatase (EC 3.6.1.7) FGW37_RS23360 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FGW37_RS23400 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FGW37_RS23415 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FGW37_RS23425 ENOG4105K5M 30s ribosomal protein S16 FGW37_RS23430 ENOG41082KU UPF0109 protein FGW37_RS23435 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FGW37_RS23440 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FGW37_RS23445 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FGW37_RS23460 ENOG4107QYR Signal peptidase i FGW37_RS23480 ENOG41080R2 UPF0102 protein FGW37_RS23495 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FGW37_RS23510 ENOG4105CE9 30S ribosomal protein S2 FGW37_RS23515 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FGW37_RS23520 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FGW37_RS23525 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FGW37_RS23535 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FGW37_RS23545 ENOG4108I5D sulfate abc transporter FGW37_RS23550 ENOG4108UCS ABC, transporter FGW37_RS23570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FGW37_RS23580 ENOG4105C26 Dehydrogenase FGW37_RS23595 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FGW37_RS23615 ENOG4105C26 Dehydrogenase FGW37_RS23630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS23635 ENOG4105F38 ABC transporter, permease FGW37_RS23640 ENOG4105D38 putrescine abc transporter FGW37_RS23645 ENOG4105CJP fad dependent oxidoreductase FGW37_RS23670 ENOG4105G9B Transcriptional regulator FGW37_RS23690 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FGW37_RS23695 ENOG4105DZP Membrane-associated zinc metalloprotease FGW37_RS23700 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FGW37_RS23715 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FGW37_RS23735 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) FGW37_RS23750 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FGW37_RS23760 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FGW37_RS23765 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FGW37_RS23820 ENOG4105EC2 ftsk spoIIIe FGW37_RS23830 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FGW37_RS23835 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FGW37_RS23840 ENOG4105C1V Peptidase, M16 FGW37_RS23845 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FGW37_RS23870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FGW37_RS23875 ENOG4105CN5 Metallo-Beta-Lactamase FGW37_RS23910 ENOG4105BZU Histidine kinase FGW37_RS23915 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FGW37_RS23920 ENOG4107QZI cell division protein FtsK FGW37_RS23930 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FGW37_RS23940 ENOG4105CEV competence damage-inducible protein FGW37_RS23945 ENOG4105WBV Transcriptional regulator FGW37_RS23965 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FGW37_RS23970 ENOG4107QRT dEAD DEAH box helicase FGW37_RS23990 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FGW37_RS24015 ENOG4105DRP amino acid AbC transporter FGW37_RS24020 ENOG4108Q1T ABC transporter FGW37_RS24030 ENOG4105CDA abc transporter atp-binding protein FGW37_RS24040 ENOG4105EB3 Histidine kinase FGW37_RS24050 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FGW37_RS24070 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FGW37_RS24080 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FGW37_RS24085 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FGW37_RS24095 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FGW37_RS24130 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FGW37_RS24135 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FGW37_RS24140 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FGW37_RS24155 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FGW37_RS24175 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FGW37_RS24185 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FGW37_RS24200 ENOG4105C9U ATP-dependent DNA helicase RecQ FGW37_RS24225 ENOG4105JXH GntR family transcriptional regulator FGW37_RS24230 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FGW37_RS24235 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FGW37_RS24245 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FGW37_RS24250 ENOG4108MRH transcriptional regulatory protein FGW37_RS24255 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FGW37_RS24265 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FGW37_RS24280 ENOG4105BZN citrate synthase FGW37_RS24285 ENOG4105BZN citrate synthase FGW37_RS24295 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FGW37_RS24300 ENOG4107RAN Peptidase, M16 FGW37_RS24315 ENOG4105DRR Transcriptional regulator, GntR family FGW37_RS24320 ENOG410849S phosphocarrier protein (HPr) FGW37_RS24325 ENOG4105CD5 CoA-binding domain protein FGW37_RS24340 ENOG4107W53 thymidine kinase FGW37_RS24350 ENOG4105KHC sulfurtransferase FGW37_RS24375 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FGW37_RS24390 ENOG4105F44 Two component transcriptional regulator, winged helix family FGW37_RS24395 ENOG4106F60 Histidine kinase FGW37_RS24420 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FGW37_RS24435 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FGW37_RS24440 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FGW37_RS24445 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FGW37_RS24485 ENOG4107VEG TrkA-N domain protein FGW37_RS24500 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FGW37_RS24510 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FGW37_RS24535 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FGW37_RS24540 ENOG4108YYH Nadph-dependent fmn reductase FGW37_RS24545 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FGW37_RS24550 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS24580 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FGW37_RS24615 ENOG4105C0X amino acid FGW37_RS24620 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FGW37_RS24635 ENOG4107QRT dEAD DEAH box helicase FGW37_RS24705 ENOG4105D9P serine threonine protein kinase FGW37_RS24730 ENOG4107VDP teichoic acid biosynthesis FGW37_RS24770 ENOG4107QK5 Homocysteine s-methyltransferase FGW37_RS24790 ENOG4107S1Q Phosphatase FGW37_RS24805 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS24825 ENOG4108UKI Enoyl-CoA hydratase FGW37_RS24830 ENOG4105DBV ornithine carbamoyltransferase FGW37_RS24835 ENOG4105CEU Arginine dihydrolase FGW37_RS24840 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FGW37_RS24850 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FGW37_RS24855 ENOG4107QM5 aconitate hydratase FGW37_RS24975 ENOG4105E2R ROK family FGW37_RS24980 ENOG4105DFW ABC transporter FGW37_RS24990 ENOG4108HWW ABC transporter FGW37_RS24995 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FGW37_RS25000 ENOG4105CUB amino acid FGW37_RS25025 ENOG4105N98 Capsule biosynthesis protein capB FGW37_RS25050 ENOG4105MC2 DSBA oxidoreductase FGW37_RS25080 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FGW37_RS25085 ENOG4105CHU acetyl-coa acetyltransferase FGW37_RS25105 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FGW37_RS25140 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FGW37_RS25160 ENOG4105CHU acetyl-coa acetyltransferase FGW37_RS25165 ENOG4105C1Q protoporphyrinogen oxidase FGW37_RS25170 ENOG4107JTW chlorite dismutase FGW37_RS25190 ENOG4105DBE peroxidase FGW37_RS25205 ENOG4105BZ4 penicillin-binding protein FGW37_RS25220 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FGW37_RS25260 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FGW37_RS25265 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FGW37_RS25270 ENOG4108XG2 Histidine kinase FGW37_RS25275 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS25280 ENOG4105DFU Cell wall formation (By similarity) FGW37_RS25285 ENOG4105E0X reductase FGW37_RS25305 ENOG4108KB2 LysR family Transcriptional regulator FGW37_RS25335 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin FGW37_RS25355 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FGW37_RS25385 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FGW37_RS25405 ENOG4107RR1 TRANSCRIPTIONal FGW37_RS25415 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FGW37_RS25425 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FGW37_RS25460 ENOG4105DRR Transcriptional regulator, GntR family FGW37_RS25480 ENOG4105C7N Xanthine uracil vitamin C permease FGW37_RS25485 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FGW37_RS25515 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FGW37_RS25540 ENOG4108JJA ABC, transporter FGW37_RS25555 ENOG4105D7N magnesium and cobalt transport protein CorA FGW37_RS25580 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FGW37_RS25585 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS25595 ENOG41060W2 glyoxylate carboligase FGW37_RS25600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FGW37_RS25605 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FGW37_RS25620 ENOG4107TXC Transcriptional regulator FGW37_RS25630 ENOG4105VT2 5-hydroxyisourate hydrolase FGW37_RS25640 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FGW37_RS25645 ENOG4105C2W permease FGW37_RS25650 ENOG4105CSX c4-dicarboxylate anaerobic carrier FGW37_RS25655 ENOG4107R9S Malate synthase FGW37_RS25670 ENOG4107HP6 Transcriptional regulator FGW37_RS25680 ENOG4105DHG Allantoate amidinohydrolase FGW37_RS25705 ENOG4105EGE secreted protein FGW37_RS25735 ENOG41062B0 ABC transporter, permease FGW37_RS25740 ENOG4105C2J ABC transporter FGW37_RS25745 ENOG4105DKQ ROK family FGW37_RS25800 ENOG4105CPC Aldo Keto reductase FGW37_RS25820 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FGW37_RS25885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FGW37_RS25890 ENOG4105DBV ornithine carbamoyltransferase FGW37_RS25905 ENOG4105C3M thioredoxin reductase FGW37_RS25925 ENOG4105X7H acyl-CoA dehydrogenase FGW37_RS25930 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FGW37_RS25935 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F FGW37_RS25990 ENOG4105CDA abc transporter atp-binding protein FGW37_RS25995 ENOG4107UBR Extracellular solute-binding protein family 3 FGW37_RS26000 ENOG4105EAD ABC transporter FGW37_RS26005 ENOG4105DRP amino acid AbC transporter FGW37_RS26015 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FGW37_RS26020 ENOG41081JD Transcriptional regulator FGW37_RS26025 ENOG4108VQR secreted hydrolase FGW37_RS26030 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FGW37_RS26040 ENOG4105D3W isochorismatase FGW37_RS26060 ENOG4105C8Y Acetylornithine aminotransferase FGW37_RS26065 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FGW37_RS26075 ENOG4105DF9 Lipoate-protein, ligase FGW37_RS26085 ENOG4105ECY inositol monophosphatase FGW37_RS26095 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FGW37_RS26120 ENOG4108IND Tetr family transcriptional regulator FGW37_RS26125 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FGW37_RS26130 ENOG4105C94 Transporter FGW37_RS26135 ENOG4105BZW Glycerate kinase FGW37_RS26145 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FGW37_RS26150 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS26160 ENOG4105CI0 Citrate lyase FGW37_RS26180 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FGW37_RS26200 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FGW37_RS26235 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FGW37_RS26250 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS26270 ENOG4108ME1 Peptidase M55 D-aminopeptidase FGW37_RS26275 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FGW37_RS26285 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FGW37_RS26290 ENOG4105E4F Isochorismate synthase FGW37_RS26295 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FGW37_RS26300 ENOG4105WQI isochorismatase FGW37_RS26305 ENOG4105WQI isochorismatase FGW37_RS26310 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS26310 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS26350 ENOG4105M4P Tetr family transcriptional regulator FGW37_RS26355 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FGW37_RS26360 ENOG4105D5Q Arginine ornithine antiporter FGW37_RS26405 ENOG410842T Pterin carbinolamine dehydratase FGW37_RS26410 ENOG4105CVP deoxyribo-dipyrimidine photolyase FGW37_RS26415 ENOG4105CV8 reductase FGW37_RS26425 ENOG4107653 Transcriptional regulator FGW37_RS26430 ENOG4105DHU Bile acid FGW37_RS26435 ENOG4105W5A BNR Asp-box repeat protein FGW37_RS26445 ENOG410834F Transcriptional regulator FGW37_RS26450 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FGW37_RS26520 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FGW37_RS26560 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FGW37_RS26565 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FGW37_RS26590 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS26600 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS26615 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS26620 ENOG4105BZU Histidine kinase FGW37_RS26625 ENOG4105EYF MMPL domain protein FGW37_RS26635 ENOG4105F0N pyrophosphate phospho-hydrolase FGW37_RS26640 ENOG4105KF0 sporulation and cell division protein, SsgA FGW37_RS26660 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FGW37_RS26680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FGW37_RS26685 ENOG4105CHU acetyl-coa acetyltransferase FGW37_RS26690 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS26695 ENOG410846T CoA-transferase family III FGW37_RS26705 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FGW37_RS26715 ENOG4105C5H ABC transporter FGW37_RS26720 ENOG4105BZM domain protein FGW37_RS26745 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FGW37_RS26790 ENOG4105EY8 ABC transporter FGW37_RS26795 ENOG4105FBD synthase FGW37_RS26815 ENOG4105EWU Squalene--hopene cyclase FGW37_RS26830 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FGW37_RS26850 ENOG41090WU lipolytic protein G-D-S-L family FGW37_RS26890 ENOG4105CI2 imidazolone-5-propionate hydrolase FGW37_RS26925 ENOG4107RN6 Monooxygenase FGW37_RS26935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FGW37_RS26940 ENOG4105R1U AraC Family Transcriptional Regulator FGW37_RS26945 ENOG4105EU0 Major facilitator Superfamily FGW37_RS26965 ENOG4105C0W non-ribosomal peptide synthetase FGW37_RS26995 ENOG4105DQQ Major facilitator superfamily MFS_1 FGW37_RS27000 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FGW37_RS27005 ENOG4108IFG nitrite reductase, (NAD(P)H) FGW37_RS27020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FGW37_RS27050 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FGW37_RS27060 ENOG4108X7A Terpene synthase metal-binding domain-containing protein FGW37_RS27065 ENOG4105EN6 Membrane FGW37_RS27070 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FGW37_RS27075 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FGW37_RS27080 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FGW37_RS27090 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FGW37_RS27100 ENOG4107RCI amp-dependent synthetase and ligase FGW37_RS27130 ENOG4105VCQ rubredoxin FGW37_RS27135 ENOG4105Q56 cytochrome P450 FGW37_RS27165 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FGW37_RS27225 ENOG4105E0A ABC, transporter FGW37_RS27230 ENOG4108MES Periplasmic binding protein FGW37_RS27240 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS27250 ENOG4105C0R drug resistance transporter emrb qaca subfamily FGW37_RS27255 ENOG4105E93 esterase FGW37_RS27260 ENOG4105DQ5 transport system permease protein FGW37_RS27285 ENOG4105BZ1 (ABC) transporter FGW37_RS27315 ENOG4108RVA ribokinase FGW37_RS27320 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FGW37_RS27325 ENOG4105CNN ABC, transporter FGW37_RS27330 ENOG4105C2J ABC transporter FGW37_RS27335 ENOG4105ETE Transcriptional regulator (LacI family FGW37_RS27340 ENOG4107QRI Phosphoketolase FGW37_RS27370 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase FGW37_RS27385 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FGW37_RS27400 ENOG41081F0 Precorrin-8x methylmutase FGW37_RS27410 ENOG4105CTK cobaltochelatase, cobn subunit FGW37_RS27470 ENOG4105F0K SARP family transcriptional regulator FGW37_RS27510 ENOG4107QHQ amino acid FGW37_RS27525 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FGW37_RS27540 ENOG4107S8C mandelate racemase muconate lactonizing FGW37_RS27565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS27605 ENOG4105BZU Histidine kinase FGW37_RS27610 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS27615 ENOG4105MSY salicylate hydroxylase FGW37_RS27625 ENOG4105CUB amino acid FGW37_RS27630 ENOG4105CWX Alpha-1,2-mannosidase FGW37_RS27655 ENOG41067HS methyltransferase FGW37_RS27660 ENOG4108V75 Glutamine amidotransferase FGW37_RS27665 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FGW37_RS27690 ENOG4105E39 Enoyl-CoA hydratase FGW37_RS27695 ENOG4105CSU acyl-Coa dehydrogenase FGW37_RS27710 ENOG4105WKW Pfam:DUF1458 FGW37_RS27715 ENOG4108KXV response regulator FGW37_RS27720 ENOG41065SU Two-component system sensor kinase FGW37_RS27750 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS27755 ENOG4105CC9 acyl-Coa dehydrogenase FGW37_RS27765 ENOG4108BAS reductase FGW37_RS27770 ENOG4108RZE Tetr family transcriptional regulator FGW37_RS27775 ENOG4105F2C Acetyl-CoA acetyltransferase FGW37_RS27780 ENOG4105EA8 2-Nitropropane dioxygenase FGW37_RS27815 ENOG4105CJ1 ABC, transporter FGW37_RS27855 ENOG4105BZ7 extracellular solute-binding protein family 1 FGW37_RS27860 ENOG4105ETE Transcriptional regulator (LacI family FGW37_RS27875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FGW37_RS27880 ENOG4105C3U ABC transporter FGW37_RS27885 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS27890 ENOG4107Y9U Membrane FGW37_RS27895 ENOG4105CRK lysyL-tRNA synthetase FGW37_RS27905 ENOG4105ESN nucleotide-binding protein FGW37_RS27910 ENOG4105ESN nucleotide-binding protein FGW37_RS27930 ENOG4108YYC ycei family FGW37_RS27940 ENOG4105C0D helicase FGW37_RS27965 ENOG4105FBN Acid phosphatase FGW37_RS27995 ENOG4105GWZ Roadblock lc7 family protein FGW37_RS28005 ENOG4105C29 acyl-CoA thioesterase FGW37_RS28020 ENOG4105BZ1 (ABC) transporter FGW37_RS28035 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FGW37_RS28040 ENOG4105BZ1 (ABC) transporter FGW37_RS28045 ENOG4105CSH Transporter FGW37_RS28055 ENOG41080R8 Conserved Protein FGW37_RS28065 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FGW37_RS28070 ENOG4107S2E monooxygenase FGW37_RS28075 ENOG4107ZED Uncharacterised protein family UPF0047 FGW37_RS28085 ENOG4108YXU transcriptional regulator AsnC family FGW37_RS28090 ENOG4108JQ6 ABC transporter FGW37_RS28095 ENOG4108EU3 peptide transport system, permease FGW37_RS28100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FGW37_RS28105 ENOG4108J59 Extracellular solute-binding protein, family 5 FGW37_RS28130 ENOG4107QI1 Mate efflux family protein FGW37_RS28140 ENOG4105DJ2 Major Facilitator Superfamily FGW37_RS28155 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) FGW37_RS28160 ENOG4105DXM phenylacetic acid degradation protein FGW37_RS28170 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FGW37_RS28185 ENOG4106NZI LysR family Transcriptional regulator FGW37_RS28195 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FGW37_RS28210 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FGW37_RS28215 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FGW37_RS28220 ENOG4105YVS arsR family transcriptional regulator FGW37_RS28235 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FGW37_RS28245 ENOG410841Q phosphoesterase PA-phosphatase related protein FGW37_RS28270 ENOG4105EAD ABC transporter FGW37_RS28275 ENOG4107R0W ABC transporter FGW37_RS28315 ENOG4105C10 Electron transfer flavoprotein FGW37_RS28325 ENOG4105ETE Transcriptional regulator (LacI family FGW37_RS28360 ENOG4106UW1 Major Facilitator superfamily FGW37_RS28365 ENOG4105E2R ROK family FGW37_RS28395 ENOG4105MVE transcriptional regulator FGW37_RS28405 ENOG4106F1P AAA ATPase, central domain protein FGW37_RS28425 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FGW37_RS28470 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FGW37_RS28510 ENOG4107QTZ amino acid FGW37_RS28515 ENOG4105C85 amino acid FGW37_RS28570 ENOG4107RRZ synthase FGW37_RS28575 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FGW37_RS28585 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FGW37_RS28590 ENOG4105DND Transcriptional regulator FGW37_RS28595 ENOG4105DQR SNARE associated Golgi FGW37_RS28610 ENOG4105C26 Dehydrogenase FGW37_RS28615 ENOG4105BZ1 (ABC) transporter FGW37_RS28625 ENOG4108IJ0 Aspartate ammonia-lyase FGW37_RS28630 ENOG4105HDK L-asparaginase FGW37_RS28635 ENOG4105EW9 transcriptional regulator AsnC family FGW37_RS28640 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FGW37_RS28690 ENOG4105D7D AAA ATPase FGW37_RS28755 ENOG4108SEA Esterase FGW37_RS28795 ENOG4105EBR Carboxylesterase FGW37_RS28800 ENOG4105W1N transcriptional regulator FGW37_RS28820 ENOG4107URF beta-phospho-glucomutase FGW37_RS28825 ENOG4105CXN decarboxylase FGW37_RS28855 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FGW37_RS28870 ENOG4106A3M Cytochrome p-450 FGW37_RS28875 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FGW37_RS28880 ENOG4105E7U AraC family transcriptional regulator FGW37_RS28885 ENOG4105CY0 Metallo-Beta-Lactamase FGW37_RS28900 ENOG41082YX Transcriptional regulator, arsr family FGW37_RS28920 ENOG4105C0X amino acid FGW37_RS28960 ENOG410880H cysteine synthase FGW37_RS28980 ENOG4108Z6Z Transcriptional regulator FGW37_RS28995 ENOG4105EG6 Saccharopine dehydrogenase FGW37_RS29025 ENOG4105E1F short-chain dehydrogenase reductase FGW37_RS29070 ENOG4105BZU Histidine kinase FGW37_RS29075 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS29085 ENOG4106A3M Cytochrome p-450 FGW37_RS29090 ENOG4108ZHJ Organic hydroperoxide resistance protein FGW37_RS29095 ENOG4105K56 Transcriptional regulator FGW37_RS29115 ENOG4107RSM transcriptional regulator FGW37_RS29130 ENOG4105ETS cytosine purines uracil thiamine allantoin FGW37_RS29155 ENOG4108KIH Inherit from NOG: halimadienyl-diphosphate synthase activity FGW37_RS29160 ENOG4107HP6 Transcriptional regulator FGW37_RS29165 ENOG4105JZI cytochrome P450 FGW37_RS29200 ENOG4105EFA 4-hydroxyphenylacetate FGW37_RS29205 ENOG4105CAQ asparagine synthetase FGW37_RS29210 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FGW37_RS29220 ENOG4108JU3 Alkyl hydroperoxide reductase FGW37_RS29275 ENOG4105BZ1 (ABC) transporter FGW37_RS29300 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FGW37_RS29305 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FGW37_RS29310 ENOG4105CAS nag kinase FGW37_RS29315 ENOG4105C8Y Acetylornithine aminotransferase FGW37_RS29325 ENOG4105WQI isochorismatase FGW37_RS29330 ENOG4108HUF Transporter FGW37_RS29355 ENOG4105BZ1 (ABC) transporter FGW37_RS29360 ENOG4105Q26 Siderophore-interacting protein FGW37_RS29365 ENOG4105DQ5 transport system permease protein FGW37_RS29370 ENOG4105TVJ transport system, permease FGW37_RS29395 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FGW37_RS29415 ENOG4105DCG PHP domain protein FGW37_RS29450 ENOG4105K6T rare lipoprotein A FGW37_RS29460 ENOG4107R13 MMPL domain protein FGW37_RS29505 ENOG4105E8G Major facilitator Superfamily FGW37_RS29510 ENOG4105CJA serine threonine protein kinase FGW37_RS29515 ENOG4105CJA serine threonine protein kinase FGW37_RS29525 ENOG4105BZU Histidine kinase FGW37_RS29545 ENOG4105CMT Dihydroxyacetone kinase FGW37_RS29635 ENOG4108DT4 serine threonine protein kinase FGW37_RS29690 ENOG4105CDU Replicative dna helicase FGW37_RS29770 ENOG4105ECQ AraC Family Transcriptional Regulator FGW37_RS29855 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FGW37_RS29865 ENOG4105FDP GntR family transcriptional regulator FGW37_RS29880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FGW37_RS29890 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FGW37_RS29965 ENOG4107R9S Malate synthase FGW37_RS29980 ENOG4105C71 hydrolase family 65, central catalytic FGW37_RS29985 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FGW37_RS29990 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FGW37_RS29995 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FGW37_RS30035 ENOG41068HZ 50S ribosomal protein L32 FGW37_RS30140 ENOG4105C85 amino acid FGW37_RS30160 ENOG4105C8S subunit m FGW37_RS30165 ENOG4105MKQ Monovalent cation H antiporter subunit C FGW37_RS30210 ENOG4105DIA mandelate racemase muconate lactonizing FGW37_RS30215 ENOG4108W6C Dehydrogenase FGW37_RS30220 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FGW37_RS30225 ENOG4107R7Y intracellular protease Pfpi family FGW37_RS30230 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FGW37_RS30245 ENOG4107SM8 Adenylate Guanylate cyclase FGW37_RS30250 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FGW37_RS30255 ENOG4105C57 major facilitator superfamily FGW37_RS30260 ENOG41080HT Transcriptional regulator, arsr family FGW37_RS30270 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FGW37_RS30275 ENOG4108XHQ (2Fe-2S)-binding domain protein FGW37_RS30285 ENOG4105DMQ Methyltransferase FGW37_RS30325 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FGW37_RS30330 ENOG4105CS1 NAD(P)H quinone oxidoreductase FGW37_RS30335 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FGW37_RS30355 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FGW37_RS30395 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein FGW37_RS30410 ENOG4108FKE two-component system sensor kinase FGW37_RS30415 ENOG4105KVH Transcriptional regulator FGW37_RS30420 ENOG4105D7V transposase FGW37_RS30480 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FGW37_RS30490 ENOG4107TDF Formate hydrogenlyase subunit 4 FGW37_RS30500 ENOG4108JPZ Monovalent cation H antiporter subunit D FGW37_RS30505 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FGW37_RS30550 ENOG4105BZ1 (ABC) transporter FGW37_RS30555 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FGW37_RS30565 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FGW37_RS30575 ENOG4105DQ4 alcohol dehydrogenase FGW37_RS30590 ENOG4108UVJ appr-1-p processing domain protein FGW37_RS30595 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS30600 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR FGW37_RS30605 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FGW37_RS30610 ENOG4105H3G oxidoreductase FGW37_RS30615 ENOG4105C9B Cysteine desulfurase FGW37_RS30645 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS30650 ENOG4105C1G acyl-Coa dehydrogenase FGW37_RS30655 ENOG4107RCI amp-dependent synthetase and ligase FGW37_RS30685 ENOG4105Q56 cytochrome P450 FGW37_RS30710 ENOG4105KNA -acetyltransferase FGW37_RS30800 ENOG4105ECQ AraC Family Transcriptional Regulator FGW37_RS30835 ENOG4105CXN decarboxylase FGW37_RS30860 ENOG4105DKQ ROK family FGW37_RS30890 ENOG4105C7K acetolactate synthase FGW37_RS30920 ENOG4108MTT Glutamate-rich protein grpB FGW37_RS30935 ENOG4105JZI cytochrome P450 FGW37_RS30960 ENOG4105BZ1 (ABC) transporter FGW37_RS31030 ENOG4105D9U N-acetyltransferase FGW37_RS31040 ENOG4105DTA methyltransferase FGW37_RS31055 ENOG4105CNN ABC, transporter FGW37_RS31060 ENOG4105C2J ABC transporter FGW37_RS31095 ENOG4105C85 amino acid FGW37_RS31120 ENOG4105IDI abc transporter atp-binding protein FGW37_RS31130 ENOG4105D9P serine threonine protein kinase FGW37_RS31150 ENOG4105ESN nucleotide-binding protein FGW37_RS31150 ENOG4105ESN nucleotide-binding protein FGW37_RS31155 ENOG4105C9B Cysteine desulfurase FGW37_RS31165 ENOG4105CY0 Metallo-Beta-Lactamase FGW37_RS31190 ENOG4108JU3 Alkyl hydroperoxide reductase FGW37_RS31220 ENOG4108SEA Esterase FGW37_RS31225 ENOG4105FF5 Membrane FGW37_RS31245 ENOG41082JN Transcriptional regulator FGW37_RS31265 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FGW37_RS31275 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) FGW37_RS31320 ENOG4105DQE DNA ligase FGW37_RS31335 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FGW37_RS31355 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FGW37_RS31365 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FGW37_RS31410 ENOG41064MX Tetr family transcriptional regulator FGW37_RS31415 ENOG4108IG5 Transcriptional regulator FGW37_RS31425 ENOG4108JIK carboxylase FGW37_RS31445 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) FGW37_RS31515 ENOG4105VEQ Cold shock protein FGW37_RS31550 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS31595 ENOG41080VW acetyltransferase FGW37_RS31605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FGW37_RS31670 ENOG4105D9U N-acetyltransferase FGW37_RS31690 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FGW37_RS31730 ENOG4108CIP transcriptional regulator FGW37_RS31755 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FGW37_RS31770 ENOG4105D64 Mechanosensitive ion channel FGW37_RS31795 ENOG4105CPC Aldo Keto reductase FGW37_RS31800 ENOG4108V06 Glutathione peroxidase FGW37_RS31830 ENOG4105C5F glutamine synthetase FGW37_RS31835 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FGW37_RS31850 ENOG4105WH1 Two component transcriptional regulator luxr family FGW37_RS31855 ENOG4105ENE Histidine kinase FGW37_RS31870 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FGW37_RS31895 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FGW37_RS31940 ENOG4107R13 MMPL domain protein FGW37_RS31950 ENOG4108RAV Conserved protein FGW37_RS31960 ENOG4105DGI Alkaline phosphatase FGW37_RS31995 ENOG4105ECP epimerase FGW37_RS32015 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FGW37_RS32020 ENOG4108SEA Esterase FGW37_RS32025 ENOG410829K Lysine exporter protein (Lyse ygga) FGW37_RS32065 ENOG4107B2H carbonic anhydrase FGW37_RS32070 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FGW37_RS32090 ENOG4108PA7 Methyltransferase FGW37_RS32100 ENOG4105DQE DNA ligase FGW37_RS32110 ENOG41067HS methyltransferase FGW37_RS32120 ENOG4105CH6 catalase FGW37_RS32130 ENOG4105CEY Amp-dependent synthetase and ligase FGW37_RS32135 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FGW37_RS32150 ENOG4105C7W Xanthine dehydrogenase FGW37_RS32155 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FGW37_RS32160 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FGW37_RS32190 ENOG4105F0K SARP family transcriptional regulator FGW37_RS32200 ENOG4105ECB domain protein FGW37_RS32215 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FGW37_RS32320 ENOG4108Z7F N-acetyltransferase FGW37_RS32400 ENOG4105C1J atp-dependent rna helicase FGW37_RS32415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FGW37_RS32470 ENOG4105ERR inositol mono-phosphatase FGW37_RS32515 ENOG4105CNA YD repeat protein FGW37_RS32535 ENOG4105C26 Dehydrogenase FGW37_RS32555 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FGW37_RS32580 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FGW37_RS32590 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FGW37_RS32620 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FGW37_RS32635 ENOG4107EEY synthase FGW37_RS32640 ENOG4107EEY synthase FGW37_RS32700 ENOG4106YKD Cytochrome p-450