locus-tag	class	description
FMM49_RS00045	COG1074	ATP-dependent DNA helicase activity
FMM49_RS00090	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FMM49_RS00140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS00330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FMM49_RS00390	COG1309	transcriptional regulator
FMM49_RS00530	COG2188	Transcriptional regulator
FMM49_RS00655	COG1660	Displays ATPase and GTPase activities
FMM49_RS00770	COG1192	Involved in chromosome partitioning
FMM49_RS00775	COG1475	DNA binding
FMM49_RS00780	COG2801	Transposase and inactivated derivatives
FMM49_RS00780	COG3415	Transposase
FMM49_RS00795	COG4974	Belongs to the 'phage' integrase family
FMM49_RS01125	COG4221	oxidoreductase activity
FMM49_RS01195	COG2234	aminopeptidase activity
FMM49_RS01240	COG2353	YceI-like domain
FMM49_RS01245	COG0583	DNA-binding transcription factor activity
FMM49_RS01255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS01265	COG0431	NADPH-dependent FMN reductase
FMM49_RS01485	COG1309	transcriptional regulator
FMM49_RS01590	COG2124	cytochrome p450
FMM49_RS01655	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
FMM49_RS01670	COG0596	Alpha beta hydrolase
FMM49_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS01690	COG0583	DNA-binding transcription factor activity
FMM49_RS01715	COG2814	Major facilitator Superfamily
FMM49_RS01725	COG1051	belongs to the nudix hydrolase family
FMM49_RS01765	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS01770	COG1309	transcriptional regulator
FMM49_RS01785	COG4948	Mandelate Racemase Muconate Lactonizing
FMM49_RS01875	COG2409	Drug exporters of the RND superfamily
FMM49_RS01880	COG0367	asparagine synthase
FMM49_RS01885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FMM49_RS01895	COG2124	cytochrome p450
FMM49_RS01910	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FMM49_RS01910	COG1672	PFAM Archaeal ATPase
FMM49_RS01940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FMM49_RS01960	COG3437	response regulator, receiver
FMM49_RS01960	COG2205	protein histidine kinase activity
FMM49_RS01960	COG4999	Histidine kinase
FMM49_RS01960	COG3850	Histidine kinase
FMM49_RS01975	COG2226	methyltransferase
FMM49_RS02000	COG0018	arginyl-trna synthetase
FMM49_RS02035	COG0488	(ABC) transporter
FMM49_RS02040	COG0488	(ABC) transporter
FMM49_RS02050	COG1309	transcriptional regulator
FMM49_RS02080	COG1175	transmembrane transport
FMM49_RS02085	COG0395	ABC-type sugar transport system, permease component
FMM49_RS02090	COG0366	Alpha amylase catalytic
FMM49_RS02125	COG2910	NAD(P)H-binding
FMM49_RS02150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FMM49_RS02160	COG1396	sequence-specific DNA binding
FMM49_RS02170	COG1309	transcriptional regulator
FMM49_RS02190	COG2367	Beta-lactamase
FMM49_RS02220	COG0778	Nitroreductase
FMM49_RS02230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FMM49_RS02230	COG2755	lipolytic protein G-D-S-L family
FMM49_RS02250	COG1309	transcriptional regulator
FMM49_RS02260	COG2340	Cysteine-rich secretory protein family
FMM49_RS02280	COG0181	hydroxymethylbilane synthase activity
FMM49_RS02300	COG1131	(ABC) transporter
FMM49_RS02315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FMM49_RS02330	COG1278	Cold shock
FMM49_RS02350	COG2197	response regulator
FMM49_RS02355	COG0142	geranyltranstransferase activity
FMM49_RS02385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FMM49_RS02385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FMM49_RS02410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FMM49_RS02420	COG3012	SEC-C Motif Domain Protein
FMM49_RS02485	COG2208	phosphoserine phosphatase activity
FMM49_RS02485	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS02485	COG2172	sigma factor antagonist activity
FMM49_RS02580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS02585	COG0463	Glycosyl transferase, family 2
FMM49_RS02625	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS02645	COG1309	transcriptional regulator
FMM49_RS02675	COG1797	cobyrinic acid a,c-diamide synthase activity
FMM49_RS02685	COG0148	phosphopyruvate hydratase activity
FMM49_RS02700	COG1309	transcriptional regulator
FMM49_RS02725	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS02760	COG4221	oxidoreductase activity
FMM49_RS02770	COG1278	Cold shock
FMM49_RS02830	COG1140	nitrate reductase beta subunit
FMM49_RS02855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FMM49_RS02870	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FMM49_RS02875	COG2079	MmgE PrpD family protein
FMM49_RS02880	COG3800	Transcriptional regulator
FMM49_RS02880	COG1396	sequence-specific DNA binding
FMM49_RS02885	COG2080	2 iron, 2 sulfur cluster binding
FMM49_RS02890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FMM49_RS02895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FMM49_RS02905	COG3629	intracellular signal transduction
FMM49_RS02925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FMM49_RS02935	COG0367	asparagine synthase
FMM49_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS02980	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FMM49_RS03020	COG2197	response regulator
FMM49_RS03050	COG2124	cytochrome p450
FMM49_RS03055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FMM49_RS03065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS03115	COG0116	Belongs to the methyltransferase superfamily
FMM49_RS03115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FMM49_RS03160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS03185	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS03390	COG3547	Transposase (IS116 IS110 IS902 family)
FMM49_RS03415	COG0739	heme binding
FMM49_RS03470	COG0494	nUDIX hydrolase
FMM49_RS03555	COG1309	transcriptional regulator
FMM49_RS03650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FMM49_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS03660	COG0604	alcohol dehydrogenase
FMM49_RS03660	COG3321	synthase
FMM49_RS03680	COG1181	Belongs to the D-alanine--D-alanine ligase family
FMM49_RS03750	COG3883	PFAM NLP P60 protein
FMM49_RS03750	COG0791	NLP P60 protein
FMM49_RS03940	COG1309	transcriptional regulator
FMM49_RS03975	COG1140	nitrate reductase beta subunit
FMM49_RS03980	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FMM49_RS04000	COG2197	response regulator
FMM49_RS04090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FMM49_RS04110	COG2226	methyltransferase
FMM49_RS04125	COG3021	interspecies interaction between organisms
FMM49_RS04135	COG3547	Transposase (IS116 IS110 IS902 family)
FMM49_RS04160	COG2755	lipolytic protein G-D-S-L family
FMM49_RS04190	COG1585	Membrane protein implicated in regulation of membrane protease activity
FMM49_RS04215	COG1215	transferase activity, transferring glycosyl groups
FMM49_RS04220	COG0515	serine threonine protein kinase
FMM49_RS04255	COG1454	alcohol dehydrogenase
FMM49_RS04260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FMM49_RS04310	COG4221	oxidoreductase activity
FMM49_RS04340	COG1116	anion transmembrane transporter activity
FMM49_RS04350	COG0604	alcohol dehydrogenase
FMM49_RS04350	COG3321	synthase
FMM49_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS04365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FMM49_RS04380	COG1309	transcriptional regulator
FMM49_RS04390	COG0640	Transcriptional regulator
FMM49_RS04405	COG2124	cytochrome p450
FMM49_RS04420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FMM49_RS04430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FMM49_RS04455	COG0697	spore germination
FMM49_RS04470	COG0640	Transcriptional regulator
FMM49_RS04495	COG3655	Transcriptional regulator
FMM49_RS04530	COG0517	IMP dehydrogenase activity
FMM49_RS04530	COG0516	GMP reductase activity
FMM49_RS04535	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS04545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FMM49_RS04555	COG0477	Major facilitator Superfamily
FMM49_RS04560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FMM49_RS04570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FMM49_RS04580	COG2124	cytochrome p450
FMM49_RS04590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FMM49_RS04610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FMM49_RS04615	COG3629	intracellular signal transduction
FMM49_RS04630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FMM49_RS04635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FMM49_RS04685	COG1902	pentaerythritol trinitrate reductase activity
FMM49_RS04705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FMM49_RS04715	COG2971	BadF BadG BcrA BcrD
FMM49_RS04725	COG2706	6-phosphogluconolactonase activity
FMM49_RS04735	COG2391	methyltransferase activity
FMM49_RS04745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FMM49_RS04750	COG4257	antibiotic catabolic process
FMM49_RS04760	COG1595	DNA-templated transcription, initiation
FMM49_RS04775	COG1793	dna ligase
FMM49_RS04785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS04790	COG0300	oxidoreductase activity
FMM49_RS04790	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS04790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS04790	COG3321	synthase
FMM49_RS04805	COG2175	clavaminate synthase activity
FMM49_RS04840	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FMM49_RS04840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FMM49_RS04865	COG0432	Pfam Uncharacterised protein family UPF0047
FMM49_RS04870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FMM49_RS04875	COG1116	anion transmembrane transporter activity
FMM49_RS04890	COG0492	ferredoxin-NADP+ reductase activity
FMM49_RS04920	COG0477	Major facilitator Superfamily
FMM49_RS04925	COG0247	lactate metabolic process
FMM49_RS04930	COG1139	Iron-sulfur cluster binding protein
FMM49_RS04935	COG1556	Lactate utilization protein
FMM49_RS04965	COG1132	(ABC) transporter
FMM49_RS04995	COG1132	(ABC) transporter
FMM49_RS05000	COG1132	(ABC) transporter
FMM49_RS05015	COG1946	Acyl-CoA thioesterase
FMM49_RS05020	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS05025	COG3962	Belongs to the TPP enzyme family
FMM49_RS05035	COG0156	8-amino-7-oxononanoate synthase activity
FMM49_RS05040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FMM49_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS05070	COG2018	Roadblock/LC7 domain
FMM49_RS05090	COG4122	O-methyltransferase activity
FMM49_RS05125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FMM49_RS05150	COG2353	YceI-like domain
FMM49_RS05155	COG2040	homocysteine
FMM49_RS05160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FMM49_RS05165	COG0765	amino acid transport
FMM49_RS05170	COG1126	abc transporter atp-binding protein
FMM49_RS05175	COG3458	cephalosporin-C deacetylase activity
FMM49_RS05185	COG1070	Carbohydrate kinase
FMM49_RS05195	COG1846	Transcriptional regulator
FMM49_RS05195	COG1940	carbohydrate kinase activity
FMM49_RS05200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS05205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS05205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS05215	COG2267	carboxylic ester hydrolase activity
FMM49_RS05245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FMM49_RS05250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FMM49_RS05265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FMM49_RS05265	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FMM49_RS05275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FMM49_RS05285	COG1070	Carbohydrate kinase
FMM49_RS05295	COG2814	Major facilitator Superfamily
FMM49_RS05300	COG1349	DNA-binding transcription factor activity
FMM49_RS05305	COG2986	histidine ammonia-lyase
FMM49_RS05315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FMM49_RS05350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS05355	COG0601	transmembrane transport
FMM49_RS05390	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS05395	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS05400	COG0604	alcohol dehydrogenase
FMM49_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS05400	COG3321	synthase
FMM49_RS05430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS05435	COG2226	methyltransferase
FMM49_RS05470	COG3572	ergothioneine biosynthetic process
FMM49_RS05475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FMM49_RS05515	COG0823	Involved in the tonB-independent uptake of proteins
FMM49_RS05520	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FMM49_RS05520	COG5479	isomerase activity
FMM49_RS05540	COG3959	Transketolase, thiamine diphosphate binding domain
FMM49_RS05545	COG1252	NADH dehydrogenase
FMM49_RS05550	COG1063	alcohol dehydrogenase
FMM49_RS05640	COG1137	ATPase activity
FMM49_RS05650	COG3360	Dodecin
FMM49_RS05655	COG0531	amino acid
FMM49_RS05675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FMM49_RS05690	COG2319	Wd-40 repeat
FMM49_RS05690	COG4249	Peptidase C14 caspase catalytic subunit p20
FMM49_RS05695	COG0180	Tryptophanyl-tRNA synthetase
FMM49_RS05725	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS05730	COG0149	triose-phosphate isomerase activity
FMM49_RS05735	COG0698	ribose 5-phosphate isomerase
FMM49_RS05740	COG1063	alcohol dehydrogenase
FMM49_RS05755	COG0583	DNA-binding transcription factor activity
FMM49_RS05760	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS05780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FMM49_RS05800	COG1652	LysM domain
FMM49_RS05830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FMM49_RS05835	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS05840	COG1024	Enoyl-CoA hydratase
FMM49_RS05850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FMM49_RS05865	COG4762	Protein conserved in bacteria
FMM49_RS05880	COG0789	Transcriptional regulator
FMM49_RS05905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS05920	COG1940	carbohydrate kinase activity
FMM49_RS05930	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FMM49_RS05940	COG0583	DNA-binding transcription factor activity
FMM49_RS05955	COG0174	glutamine synthetase
FMM49_RS05970	COG3246	L-lysine catabolic process to acetate
FMM49_RS05975	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS05980	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS05980	COG0824	Thioesterase
FMM49_RS06010	COG1686	Belongs to the peptidase S11 family
FMM49_RS06040	COG0789	Transcriptional regulator
FMM49_RS06045	COG3959	Transketolase, thiamine diphosphate binding domain
FMM49_RS06050	COG3958	Transketolase
FMM49_RS06055	COG2267	carboxylic ester hydrolase activity
FMM49_RS06060	COG0402	S-adenosylhomocysteine deaminase activity
FMM49_RS06070	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS06090	COG2018	Roadblock/LC7 domain
FMM49_RS06120	COG0367	asparagine synthase
FMM49_RS06130	COG2814	Major facilitator Superfamily
FMM49_RS06185	COG2755	lipolytic protein G-D-S-L family
FMM49_RS06190	COG2365	Tyrosine phosphatase family
FMM49_RS06205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FMM49_RS06210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FMM49_RS06225	COG1657	PFAM Prenyltransferase squalene oxidase
FMM49_RS06235	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FMM49_RS06245	COG1562	ergosterol biosynthetic process
FMM49_RS06250	COG1134	teichoic acid transport
FMM49_RS06290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FMM49_RS06310	COG1846	Transcriptional regulator
FMM49_RS06315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FMM49_RS06325	COG1024	Enoyl-CoA hydratase
FMM49_RS06345	COG4977	sequence-specific DNA binding
FMM49_RS06360	COG2183	response to ionizing radiation
FMM49_RS06385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FMM49_RS06395	COG2936	dipeptidyl-peptidase activity
FMM49_RS06410	COG3568	Endonuclease Exonuclease Phosphatase
FMM49_RS06415	COG2197	response regulator
FMM49_RS06430	COG0477	Major facilitator Superfamily
FMM49_RS06435	COG1113	amino acid transport
FMM49_RS06450	COG1024	Enoyl-CoA hydratase
FMM49_RS06450	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS06455	COG0183	Belongs to the thiolase family
FMM49_RS06460	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS06465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FMM49_RS06470	COG1285	pathogenesis
FMM49_RS06485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FMM49_RS06490	COG3268	Saccharopine dehydrogenase
FMM49_RS06495	COG1515	deoxyribonuclease V activity
FMM49_RS06500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FMM49_RS06505	COG1309	transcriptional regulator
FMM49_RS06535	COG2814	Major facilitator Superfamily
FMM49_RS06540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FMM49_RS06550	COG1349	DNA-binding transcription factor activity
FMM49_RS06600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FMM49_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS06625	COG1024	Enoyl-CoA hydratase
FMM49_RS06625	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS06650	COG1309	transcriptional regulator
FMM49_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS06660	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS06665	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS06670	COG1289	transmembrane transporter activity
FMM49_RS06675	COG1846	Transcriptional regulator
FMM49_RS06680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FMM49_RS06710	COG0667	Aldo Keto reductase
FMM49_RS06720	COG3226	Transcriptional regulator
FMM49_RS06745	COG0745	RESPONSE REGULATOR receiver
FMM49_RS06750	COG2205	protein histidine kinase activity
FMM49_RS06780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FMM49_RS06790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FMM49_RS06835	COG0583	DNA-binding transcription factor activity
FMM49_RS06880	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS06885	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS06900	COG1376	ErfK ybiS ycfS ynhG family protein
FMM49_RS06920	COG2124	cytochrome p450
FMM49_RS06955	COG0204	Acyl-transferase
FMM49_RS06965	COG3511	phospholipase C
FMM49_RS06995	COG0287	Prephenate dehydrogenase
FMM49_RS07020	COG2124	cytochrome p450
FMM49_RS07025	COG2124	cytochrome p450
FMM49_RS07035	COG0475	glutathione-regulated potassium exporter activity
FMM49_RS07045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS07065	COG1132	(ABC) transporter
FMM49_RS07080	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FMM49_RS07100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FMM49_RS07110	COG2223	nitrite transmembrane transporter activity
FMM49_RS07120	COG0287	Prephenate dehydrogenase
FMM49_RS07120	COG1605	Chorismate mutase
FMM49_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS07175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FMM49_RS07185	COG1063	alcohol dehydrogenase
FMM49_RS07220	COG0583	DNA-binding transcription factor activity
FMM49_RS07230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FMM49_RS07265	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS07270	COG4106	trans-aconitate 2-methyltransferase activity
FMM49_RS07290	COG1595	DNA-templated transcription, initiation
FMM49_RS07295	COG1295	ribonuclease BN
FMM49_RS07300	COG2154	pterin-4-alpha-carbinolamine dehydratase
FMM49_RS07305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FMM49_RS07310	COG4941	Belongs to the sigma-70 factor family
FMM49_RS07340	COG0789	Transcriptional regulator
FMM49_RS07345	COG1309	transcriptional regulator
FMM49_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS07355	COG0531	amino acid
FMM49_RS07365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS07375	COG0431	NADPH-dependent FMN reductase
FMM49_RS07390	COG0583	DNA-binding transcription factor activity
FMM49_RS07395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FMM49_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS07435	COG4948	Mandelate Racemase Muconate Lactonizing
FMM49_RS07445	COG0517	IMP dehydrogenase activity
FMM49_RS07450	COG0671	phosphoesterase, PA-phosphatase related
FMM49_RS07455	COG2226	methyltransferase
FMM49_RS07480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS07510	COG0010	Belongs to the arginase family
FMM49_RS07530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FMM49_RS07550	COG2124	cytochrome p450
FMM49_RS07565	COG1619	proteins homologs of microcin C7 resistance protein MccF
FMM49_RS07575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FMM49_RS07580	COG2362	D-Aminopeptidase
FMM49_RS07595	COG2208	phosphoserine phosphatase activity
FMM49_RS07595	COG2172	sigma factor antagonist activity
FMM49_RS07595	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS07600	COG2207	Transcriptional regulator
FMM49_RS07635	COG0456	acetyltransferase
FMM49_RS07645	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS07660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FMM49_RS07660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FMM49_RS07665	COG2301	Belongs to the HpcH HpaI aldolase family
FMM49_RS07675	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS07680	COG0688	phosphatidylethanolamine metabolic process
FMM49_RS07690	COG1929	Belongs to the glycerate kinase type-1 family
FMM49_RS07695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FMM49_RS07710	COG2304	oxidoreductase activity
FMM49_RS07730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FMM49_RS07745	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FMM49_RS07770	COG0640	Transcriptional regulator
FMM49_RS07780	COG0483	inositol monophosphate 1-phosphatase activity
FMM49_RS07790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FMM49_RS07805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FMM49_RS07815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FMM49_RS07835	COG1064	alcohol dehydrogenase
FMM49_RS07840	COG1278	Cold shock
FMM49_RS07845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FMM49_RS07860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FMM49_RS07860	COG0723	plastoquinol--plastocyanin reductase activity
FMM49_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS07885	COG0477	Major facilitator Superfamily
FMM49_RS07890	COG1335	isochorismatase
FMM49_RS07910	COG0405	Gamma-glutamyltransferase
FMM49_RS07940	COG1959	2 iron, 2 sulfur cluster binding
FMM49_RS07945	COG1017	nitric oxide dioxygenase activity
FMM49_RS07945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FMM49_RS07955	COG0765	amino acid transport
FMM49_RS07960	COG0765	amino acid transport
FMM49_RS07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FMM49_RS07970	COG1126	abc transporter atp-binding protein
FMM49_RS08000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FMM49_RS08010	COG0483	inositol monophosphate 1-phosphatase activity
FMM49_RS08015	COG0583	DNA-binding transcription factor activity
FMM49_RS08020	COG0542	response to heat
FMM49_RS08030	COG3693	PFAM glycoside hydrolase, family 10
FMM49_RS08055	COG2814	Major facilitator Superfamily
FMM49_RS08090	COG0251	oxidation-reduction process
FMM49_RS08095	COG0583	DNA-binding transcription factor activity
FMM49_RS08110	COG1940	carbohydrate kinase activity
FMM49_RS08135	COG2188	Transcriptional regulator
FMM49_RS08140	COG0789	Transcriptional regulator
FMM49_RS08145	COG1902	pentaerythritol trinitrate reductase activity
FMM49_RS08160	COG0800	Aldolase
FMM49_RS08210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FMM49_RS08215	COG1414	Transcriptional regulator
FMM49_RS08230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FMM49_RS08240	COG1288	antiporter activity
FMM49_RS08265	COG2233	PERMEase
FMM49_RS08275	COG2233	PERMEase
FMM49_RS08285	COG2351	hydroxyisourate hydrolase activity
FMM49_RS08305	COG3622	Belongs to the hyi family
FMM49_RS08310	COG2084	Dehydrogenase
FMM49_RS08320	COG0753	catalase activity
FMM49_RS08330	COG1126	abc transporter atp-binding protein
FMM49_RS08360	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS08365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FMM49_RS08370	COG2197	response regulator
FMM49_RS08385	COG0583	DNA-binding transcription factor activity
FMM49_RS08390	COG4552	Acetyltransferase involved in intracellular survival and related
FMM49_RS08395	COG1285	pathogenesis
FMM49_RS08410	COG1733	regulation of RNA biosynthetic process
FMM49_RS08430	COG2252	PERMEase
FMM49_RS08435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FMM49_RS08485	COG0028	Belongs to the TPP enzyme family
FMM49_RS08500	COG1162	GTPase activity
FMM49_RS08530	COG1204	response to ionizing radiation
FMM49_RS08535	COG3629	intracellular signal transduction
FMM49_RS08535	COG3903	Transcriptional regulator
FMM49_RS08550	COG1309	transcriptional regulator
FMM49_RS08585	COG0028	Belongs to the TPP enzyme family
FMM49_RS08620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FMM49_RS08625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FMM49_RS08630	COG3485	protocatechuate 3,4-dioxygenase
FMM49_RS08635	COG3485	protocatechuate 3,4-dioxygenase
FMM49_RS08640	COG0183	Belongs to the thiolase family
FMM49_RS08645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FMM49_RS08650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FMM49_RS08655	COG1414	Transcriptional regulator
FMM49_RS08705	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS08730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FMM49_RS08740	COG0175	sulfate reduction
FMM49_RS08745	COG0529	Catalyzes the synthesis of activated sulfate
FMM49_RS08770	COG1116	anion transmembrane transporter activity
FMM49_RS08770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FMM49_RS08775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FMM49_RS08800	COG2936	dipeptidyl-peptidase activity
FMM49_RS08830	COG0859	PFAM glycosyl transferase family 9
FMM49_RS08840	COG1088	dTDP-glucose 4,6-dehydratase activity
FMM49_RS08845	COG2192	nodulation
FMM49_RS08855	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FMM49_RS08870	COG0297	glycogen (starch) synthase activity
FMM49_RS08875	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FMM49_RS08880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FMM49_RS08880	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FMM49_RS08890	COG1215	transferase activity, transferring glycosyl groups
FMM49_RS08965	COG2362	D-Aminopeptidase
FMM49_RS08970	COG0583	DNA-binding transcription factor activity
FMM49_RS08975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FMM49_RS09005	COG0693	protein deglycase activity
FMM49_RS09015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FMM49_RS09020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FMM49_RS09025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FMM49_RS09030	COG2197	response regulator
FMM49_RS09035	COG4585	Histidine kinase
FMM49_RS09045	COG1136	(ABC) transporter
FMM49_RS09075	COG4152	abc transporter atp-binding protein
FMM49_RS09105	COG1280	lysine exporter protein (LysE YggA)
FMM49_RS09110	COG3220	belongs to the UPF0276 family
FMM49_RS09135	COG3253	May function as heme-dependent peroxidase
FMM49_RS09140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FMM49_RS09150	COG0183	Belongs to the thiolase family
FMM49_RS09165	COG0446	pyridine nucleotide-disulphide oxidoreductase
FMM49_RS09170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FMM49_RS09185	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FMM49_RS09195	COG0183	Belongs to the thiolase family
FMM49_RS09200	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS09200	COG1024	Enoyl-CoA hydratase
FMM49_RS09215	COG0531	amino acid
FMM49_RS09220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FMM49_RS09225	COG4214	carbohydrate transport
FMM49_RS09235	COG4213	ABC transporter substrate-binding protein
FMM49_RS09240	COG1940	carbohydrate kinase activity
FMM49_RS09245	COG0395	ABC-type sugar transport system, permease component
FMM49_RS09250	COG1175	transmembrane transport
FMM49_RS09255	COG1653	transport
FMM49_RS09270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FMM49_RS09275	COG4106	trans-aconitate 2-methyltransferase activity
FMM49_RS09285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FMM49_RS09300	COG0596	Alpha beta hydrolase
FMM49_RS09315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FMM49_RS09320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FMM49_RS09335	COG2223	nitrite transmembrane transporter activity
FMM49_RS09350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FMM49_RS09360	COG1063	alcohol dehydrogenase
FMM49_RS09385	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS09390	COG1024	Enoyl-CoA hydratase
FMM49_RS09410	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS09425	COG0546	phosphoglycolate phosphatase activity
FMM49_RS09450	COG1024	Enoyl-CoA hydratase
FMM49_RS09455	COG0531	amino acid
FMM49_RS09460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FMM49_RS09465	COG2235	arginine
FMM49_RS09535	COG2197	response regulator
FMM49_RS09575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FMM49_RS09590	COG2770	Histidine kinase
FMM49_RS09590	COG2208	phosphoserine phosphatase activity
FMM49_RS09630	COG1799	cell septum assembly
FMM49_RS09635	COG0598	Magnesium transport protein CorA
FMM49_RS09645	COG0302	gtp cyclohydrolase
FMM49_RS09660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FMM49_RS09680	COG4638	Rieske (2fe-2S)
FMM49_RS09685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FMM49_RS09700	COG2986	histidine ammonia-lyase
FMM49_RS09705	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS09710	COG0156	8-amino-7-oxononanoate synthase activity
FMM49_RS09725	COG2814	Major facilitator Superfamily
FMM49_RS09730	COG0583	DNA-binding transcription factor activity
FMM49_RS09750	COG2201	protein-glutamate methylesterase activity
FMM49_RS09775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS09780	COG0601	transmembrane transport
FMM49_RS09785	COG0747	negative chemotaxis
FMM49_RS09800	COG4948	Mandelate Racemase Muconate Lactonizing
FMM49_RS09805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FMM49_RS09815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FMM49_RS09840	COG0583	DNA-binding transcription factor activity
FMM49_RS09850	COG0702	epimerase
FMM49_RS09870	COG3433	isochorismatase activity
FMM49_RS09870	COG1535	isochorismatase
FMM49_RS09875	COG1535	isochorismatase
FMM49_RS09875	COG3433	isochorismatase activity
FMM49_RS09880	COG1021	2,3-dihydroxybenzoate-AMP ligase
FMM49_RS09885	COG1169	isochorismate synthase
FMM49_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS09895	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS09900	COG2382	esterase
FMM49_RS09905	COG2814	Major facilitator Superfamily
FMM49_RS09910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS09920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FMM49_RS09925	COG1120	ATPase activity
FMM49_RS09940	COG2264	protein methyltransferase activity
FMM49_RS09970	COG2124	cytochrome p450
FMM49_RS09980	COG0477	Major facilitator Superfamily
FMM49_RS10040	COG3842	ATPase activity
FMM49_RS10055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FMM49_RS10060	COG0066	3-isopropylmalate dehydratase activity
FMM49_RS10080	COG2197	response regulator
FMM49_RS10105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS10140	COG1834	amidinotransferase
FMM49_RS10145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FMM49_RS10150	COG0134	indole-3-glycerol-phosphate synthase activity
FMM49_RS10155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FMM49_RS10165	COG0512	Glutamine amidotransferase of anthranilate synthase
FMM49_RS10165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FMM49_RS10175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FMM49_RS10195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS10200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS10215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FMM49_RS10220	COG0531	amino acid
FMM49_RS10250	COG0569	domain protein
FMM49_RS10285	COG0577	efflux transmembrane transporter activity
FMM49_RS10285	COG1136	(ABC) transporter
FMM49_RS10295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FMM49_RS10300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FMM49_RS10305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FMM49_RS10320	COG0756	dUTP diphosphatase activity
FMM49_RS10345	COG2205	protein histidine kinase activity
FMM49_RS10350	COG0745	RESPONSE REGULATOR receiver
FMM49_RS10360	COG0483	inositol monophosphate 1-phosphatase activity
FMM49_RS10365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FMM49_RS10400	COG1435	thymidine kinase activity
FMM49_RS10420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FMM49_RS10425	COG1802	Transcriptional regulator
FMM49_RS10445	COG0612	Peptidase, M16
FMM49_RS10450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FMM49_RS10460	COG0372	Belongs to the citrate synthase family
FMM49_RS10465	COG0372	Belongs to the citrate synthase family
FMM49_RS10485	COG3290	protein histidine kinase activity
FMM49_RS10490	COG4565	transcriptional regulatory protein
FMM49_RS10495	COG2197	response regulator
FMM49_RS10500	COG4585	Histidine kinase
FMM49_RS10510	COG0187	DNA topoisomerase II activity
FMM49_RS10525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FMM49_RS10530	COG2186	Transcriptional regulator
FMM49_RS10555	COG0514	ATP-dependent DNA helicase (RecQ)
FMM49_RS10570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FMM49_RS10585	COG0488	(ABC) transporter
FMM49_RS10600	COG0154	amidase activity
FMM49_RS10605	COG3226	Transcriptional regulator
FMM49_RS10620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FMM49_RS10625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FMM49_RS10630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FMM49_RS10665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FMM49_RS10675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FMM49_RS10680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FMM49_RS10690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FMM49_RS10710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FMM49_RS10725	COG1278	Cold shock
FMM49_RS10730	COG2205	protein histidine kinase activity
FMM49_RS10740	COG1126	abc transporter atp-binding protein
FMM49_RS10750	COG0765	amino acid transport
FMM49_RS10755	COG0765	amino acid transport
FMM49_RS10795	COG0628	permease
FMM49_RS10820	COG1917	Cupin 2, conserved barrel domain protein
FMM49_RS10820	COG2207	Transcriptional regulator
FMM49_RS10825	COG1201	RNA secondary structure unwinding
FMM49_RS10830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FMM49_RS10840	COG0181	hydroxymethylbilane synthase activity
FMM49_RS10855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS10860	COG0783	Belongs to the Dps family
FMM49_RS10865	COG1396	sequence-specific DNA binding
FMM49_RS10870	COG1058	Belongs to the CinA family
FMM49_RS10870	COG1546	Belongs to the CinA family
FMM49_RS10880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FMM49_RS10890	COG1674	ftsk spoiiie
FMM49_RS10900	COG4999	Histidine kinase
FMM49_RS10900	COG3437	response regulator, receiver
FMM49_RS10900	COG3850	Histidine kinase
FMM49_RS10900	COG2205	protein histidine kinase activity
FMM49_RS10905	COG2770	Histidine kinase
FMM49_RS10905	COG2208	phosphoserine phosphatase activity
FMM49_RS10935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FMM49_RS10940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FMM49_RS10945	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FMM49_RS10965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FMM49_RS10970	COG0612	Peptidase, M16
FMM49_RS10975	COG1185	polyribonucleotide nucleotidyltransferase activity
FMM49_RS10980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FMM49_RS10990	COG1674	ftsk spoiiie
FMM49_RS11110	COG0455	bacterial-type flagellum organization
FMM49_RS11120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FMM49_RS11125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FMM49_RS11135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FMM49_RS11150	COG0779	Required for maturation of 30S ribosomal subunits
FMM49_RS11165	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
FMM49_RS11170	COG0442	prolyl-tRNA aminoacylation
FMM49_RS11185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FMM49_RS11190	COG0750	zinc metalloprotease
FMM49_RS11195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FMM49_RS11210	COG2197	response regulator
FMM49_RS11215	COG4585	Histidine kinase
FMM49_RS11220	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FMM49_RS11310	COG1177	transmembrane transport
FMM49_RS11315	COG1176	ABC-type spermidine putrescine transport system, permease component I
FMM49_RS11320	COG3842	ATPase activity
FMM49_RS11330	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS11345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FMM49_RS11370	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS11380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FMM49_RS11405	COG3842	ATPase activity
FMM49_RS11410	COG4208	sulfate ABC transporter
FMM49_RS11420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FMM49_RS11430	COG0233	cytoplasmic translational termination
FMM49_RS11435	COG0528	UMP kinase activity
FMM49_RS11440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FMM49_RS11445	COG0052	Belongs to the universal ribosomal protein uS2 family
FMM49_RS11460	COG1191	sigma factor activity
FMM49_RS11475	COG0792	nuclease activity
FMM49_RS11495	COG0681	Belongs to the peptidase S26 family
FMM49_RS11505	COG0681	Belongs to the peptidase S26 family
FMM49_RS11515	COG0335	large ribosomal subunit rRNA binding
FMM49_RS11520	COG0336	Belongs to the RNA methyltransferase TrmD family
FMM49_RS11525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FMM49_RS11530	COG1837	Belongs to the UPF0109 family
FMM49_RS11535	COG0228	four-way junction DNA binding
FMM49_RS11570	COG1735	metal-dependent hydrolase with the TIM-barrel fold
FMM49_RS11575	COG0626	cystathionine gamma-synthase activity
FMM49_RS11585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FMM49_RS11595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FMM49_RS11630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FMM49_RS11640	COG0477	Major facilitator Superfamily
FMM49_RS11645	COG1196	nuclear chromosome segregation
FMM49_RS11655	COG1254	Belongs to the acylphosphatase family
FMM49_RS11675	COG1733	regulation of RNA biosynthetic process
FMM49_RS11680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FMM49_RS11685	COG0571	ribonuclease III activity
FMM49_RS11690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FMM49_RS11705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FMM49_RS11710	COG0742	ribosomal rna small subunit methyltransferase
FMM49_RS11720	COG1461	Dihydroxyacetone kinase
FMM49_RS11725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FMM49_RS11730	COG0351	phosphomethylpyrimidine kinase
FMM49_RS11750	COG1181	Belongs to the D-alanine--D-alanine ligase family
FMM49_RS11755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FMM49_RS11765	COG1920	GTP binding
FMM49_RS11775	COG0776	regulation of translation
FMM49_RS11785	COG0066	3-isopropylmalate dehydratase activity
FMM49_RS11790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FMM49_RS11795	COG1414	Transcriptional regulator
FMM49_RS11885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FMM49_RS11890	COG0179	Fumarylacetoacetate (FAA) hydrolase
FMM49_RS11905	COG2018	Roadblock/LC7 domain
FMM49_RS11925	COG2018	Roadblock/LC7 domain
FMM49_RS11940	COG2376	Dihydroxyacetone kinase
FMM49_RS11945	COG2814	Major facilitator Superfamily
FMM49_RS11960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FMM49_RS11965	COG5492	domain, Protein
FMM49_RS11970	COG2353	YceI-like domain
FMM49_RS11975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FMM49_RS11980	COG0477	Major facilitator Superfamily
FMM49_RS11990	COG1309	transcriptional regulator
FMM49_RS11995	COG2957	Belongs to the agmatine deiminase family
FMM49_RS12000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FMM49_RS12005	COG0473	3-isopropylmalate dehydrogenase activity
FMM49_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS12025	COG0506	proline dehydrogenase activity
FMM49_RS12030	COG3835	regulator
FMM49_RS12050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FMM49_RS12055	COG0440	acetolactate synthase activity
FMM49_RS12075	COG0667	Aldo Keto reductase
FMM49_RS12080	COG2133	pyrroloquinoline quinone binding
FMM49_RS12090	COG2197	response regulator
FMM49_RS12105	COG2409	Drug exporters of the RND superfamily
FMM49_RS12110	COG3511	phospholipase C
FMM49_RS12150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FMM49_RS12160	COG0154	amidase activity
FMM49_RS12165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FMM49_RS12175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FMM49_RS12185	COG4221	oxidoreductase activity
FMM49_RS12195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FMM49_RS12210	COG0667	Aldo Keto reductase
FMM49_RS12215	COG0482	sulfurtransferase activity
FMM49_RS12240	COG3903	Transcriptional regulator
FMM49_RS12240	COG3629	intracellular signal transduction
FMM49_RS12265	COG2860	membrane
FMM49_RS12285	COG4608	Belongs to the ABC transporter superfamily
FMM49_RS12290	COG0444	Belongs to the ABC transporter superfamily
FMM49_RS12295	COG0601	transmembrane transport
FMM49_RS12300	COG0747	negative chemotaxis
FMM49_RS12305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS12330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FMM49_RS12335	COG0509	glycine decarboxylation via glycine cleavage system
FMM49_RS12340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FMM49_RS12345	COG0531	amino acid
FMM49_RS12350	COG1760	l-serine dehydratase
FMM49_RS12390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FMM49_RS12410	COG0785	Cytochrome C biogenesis protein
FMM49_RS12415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FMM49_RS12415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FMM49_RS12440	COG1376	ErfK ybiS ycfS ynhG family protein
FMM49_RS12450	COG1132	(ABC) transporter
FMM49_RS12455	COG1132	(ABC) transporter
FMM49_RS12460	COG0477	Major facilitator Superfamily
FMM49_RS12465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FMM49_RS12470	COG2272	Belongs to the type-B carboxylesterase lipase family
FMM49_RS12475	COG1252	NADH dehydrogenase
FMM49_RS12480	COG1595	DNA-templated transcription, initiation
FMM49_RS12485	COG2318	DinB family
FMM49_RS12500	COG2197	response regulator
FMM49_RS12525	COG0058	SHG alpha-glucan phosphorylase activity
FMM49_RS12535	COG0366	Alpha amylase catalytic
FMM49_RS12540	COG0366	Alpha amylase catalytic
FMM49_RS12550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FMM49_RS12555	COG0667	Aldo Keto reductase
FMM49_RS12570	COG0477	Major facilitator Superfamily
FMM49_RS12580	COG1301	dicarboxylic acid transport
FMM49_RS12585	COG3290	protein histidine kinase activity
FMM49_RS12590	COG4565	transcriptional regulatory protein
FMM49_RS12600	COG1175	transmembrane transport
FMM49_RS12605	COG0395	ABC-type sugar transport system, permease component
FMM49_RS12615	COG4249	Peptidase C14 caspase catalytic subunit p20
FMM49_RS12615	COG2319	Wd-40 repeat
FMM49_RS12625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FMM49_RS12635	COG0577	efflux transmembrane transporter activity
FMM49_RS12640	COG1295	ribonuclease BN
FMM49_RS12645	COG0753	catalase activity
FMM49_RS12670	COG0205	6-phosphofructokinase activity
FMM49_RS12675	COG0280	phosphate acetyltransferase
FMM49_RS12675	COG0857	belongs to the CobB CobQ family
FMM49_RS12680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FMM49_RS12735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FMM49_RS12740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FMM49_RS12760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FMM49_RS12765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FMM49_RS12765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FMM49_RS12820	COG2205	protein histidine kinase activity
FMM49_RS12825	COG0745	RESPONSE REGULATOR receiver
FMM49_RS12845	COG0183	Belongs to the thiolase family
FMM49_RS12865	COG1131	(ABC) transporter
FMM49_RS12900	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FMM49_RS12915	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS12945	COG3850	Histidine kinase
FMM49_RS12950	COG2197	response regulator
FMM49_RS12965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FMM49_RS12970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FMM49_RS12975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FMM49_RS12980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FMM49_RS12985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FMM49_RS12990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FMM49_RS12995	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FMM49_RS13015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FMM49_RS13020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FMM49_RS13030	COG2890	protein-(glutamine-N5) methyltransferase activity
FMM49_RS13035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FMM49_RS13040	COG0254	rRNA binding
FMM49_RS13055	COG0083	homoserine kinase activity
FMM49_RS13060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FMM49_RS13065	COG0460	homoserine dehydrogenase
FMM49_RS13070	COG0019	diaminopimelate decarboxylase activity
FMM49_RS13075	COG0018	arginyl-trna synthetase
FMM49_RS13080	COG0745	RESPONSE REGULATOR receiver
FMM49_RS13105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS13135	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS13145	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS13185	COG2124	cytochrome p450
FMM49_RS13195	COG0768	penicillin binding
FMM49_RS13205	COG1119	ATPase activity
FMM49_RS13275	COG1309	transcriptional regulator
FMM49_RS13300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FMM49_RS13315	COG0745	RESPONSE REGULATOR receiver
FMM49_RS13320	COG2205	protein histidine kinase activity
FMM49_RS13325	COG0508	dehydrogenase complex catalyzes the overall conversion of
FMM49_RS13325	COG0567	Dehydrogenase, E1 component
FMM49_RS13430	COG0604	alcohol dehydrogenase
FMM49_RS13440	COG0281	malic enzyme
FMM49_RS13445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FMM49_RS13450	COG0765	amino acid transport
FMM49_RS13455	COG1126	abc transporter atp-binding protein
FMM49_RS13460	COG4106	trans-aconitate 2-methyltransferase activity
FMM49_RS13480	COG2201	protein-glutamate methylesterase activity
FMM49_RS13515	COG3629	intracellular signal transduction
FMM49_RS13515	COG3903	Transcriptional regulator
FMM49_RS13545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FMM49_RS13550	COG1993	acr, cog1993
FMM49_RS13555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FMM49_RS13560	COG2186	Transcriptional regulator
FMM49_RS13565	COG2807	transmembrane transport
FMM49_RS13570	COG0598	Magnesium transport protein CorA
FMM49_RS13585	COG0477	Major facilitator Superfamily
FMM49_RS13600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FMM49_RS13615	COG2066	Belongs to the glutaminase family
FMM49_RS13670	COG1597	lipid kinase activity
FMM49_RS13685	COG1309	transcriptional regulator
FMM49_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS13700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FMM49_RS13705	COG0363	glucosamine-6-phosphate deaminase activity
FMM49_RS13710	COG1472	Belongs to the glycosyl hydrolase 3 family
FMM49_RS13715	COG0395	ABC-type sugar transport system, permease component
FMM49_RS13720	COG1175	transmembrane transport
FMM49_RS13725	COG2182	Extracellular solute-binding protein
FMM49_RS13730	COG2188	Transcriptional regulator
FMM49_RS13735	COG1966	Carbon starvation protein
FMM49_RS13775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FMM49_RS13780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FMM49_RS13785	COG0242	peptide deformylase activity
FMM49_RS13795	COG5662	AntiSigma factor
FMM49_RS13800	COG1595	DNA-templated transcription, initiation
FMM49_RS13805	COG3800	Transcriptional regulator
FMM49_RS13805	COG1396	sequence-specific DNA binding
FMM49_RS13815	COG2135	peptidase activity
FMM49_RS13825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FMM49_RS13840	COG2076	Multidrug Resistance protein
FMM49_RS13850	COG0483	inositol monophosphate 1-phosphatase activity
FMM49_RS13860	COG0753	catalase activity
FMM49_RS13890	COG1615	UPF0182 protein
FMM49_RS13900	COG3480	Lon protease (S16) C-terminal proteolytic domain
FMM49_RS13955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FMM49_RS14005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FMM49_RS14010	COG0210	DNA helicase
FMM49_RS14055	COG4172	Belongs to the ABC transporter superfamily
FMM49_RS14060	COG0601	transmembrane transport
FMM49_RS14065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS14080	COG2267	carboxylic ester hydrolase activity
FMM49_RS14120	COG1432	Conserved Protein
FMM49_RS14130	COG2095	MarC family integral membrane protein
FMM49_RS14145	COG2814	Major facilitator Superfamily
FMM49_RS14155	COG0598	Magnesium transport protein CorA
FMM49_RS14190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FMM49_RS14195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FMM49_RS14205	COG1595	DNA-templated transcription, initiation
FMM49_RS14220	COG1024	Enoyl-CoA hydratase
FMM49_RS14225	COG0519	Catalyzes the synthesis of GMP from XMP
FMM49_RS14235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FMM49_RS14245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FMM49_RS14285	COG2197	response regulator
FMM49_RS14290	COG4585	Histidine kinase
FMM49_RS14300	COG1131	(ABC) transporter
FMM49_RS14320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FMM49_RS14340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS14345	COG4166	transmembrane transport
FMM49_RS14355	COG0444	Belongs to the ABC transporter superfamily
FMM49_RS14360	COG4608	Belongs to the ABC transporter superfamily
FMM49_RS14370	COG4608	Belongs to the ABC transporter superfamily
FMM49_RS14380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS14385	COG0601	transmembrane transport
FMM49_RS14415	COG4608	Belongs to the ABC transporter superfamily
FMM49_RS14420	COG0444	Belongs to the ABC transporter superfamily
FMM49_RS14425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FMM49_RS14430	COG0601	transmembrane transport
FMM49_RS14435	COG4166	transmembrane transport
FMM49_RS14440	COG1217	gtp-binding protein TYPA
FMM49_RS14460	COG1053	succinate dehydrogenase
FMM49_RS14490	COG0531	amino acid
FMM49_RS14505	COG0596	Alpha beta hydrolase
FMM49_RS14505	COG0508	dehydrogenase complex catalyzes the overall conversion of
FMM49_RS14535	COG0012	GTP binding
FMM49_RS14550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FMM49_RS14560	COG1570	exodeoxyribonuclease VII activity
FMM49_RS14565	COG1722	exodeoxyribonuclease VII activity
FMM49_RS14570	COG0778	Nitroreductase
FMM49_RS14595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FMM49_RS14595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FMM49_RS14600	COG0114	fumarate hydratase activity
FMM49_RS14625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FMM49_RS14640	COG1136	(ABC) transporter
FMM49_RS14655	COG1136	(ABC) transporter
FMM49_RS14680	COG0450	alkyl hydroperoxide reductase
FMM49_RS14685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FMM49_RS14705	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FMM49_RS14710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FMM49_RS14715	COG0667	Aldo Keto reductase
FMM49_RS14760	COG2885	chlorophyll binding
FMM49_RS14800	COG2894	cell division
FMM49_RS14855	COG2610	gluconate transmembrane transporter activity
FMM49_RS14860	COG0251	oxidation-reduction process
FMM49_RS14865	COG1414	Transcriptional regulator
FMM49_RS14880	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FMM49_RS14900	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FMM49_RS14915	COG0789	Transcriptional regulator
FMM49_RS14925	COG1331	Highly conserved protein containing a thioredoxin domain
FMM49_RS14945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FMM49_RS14955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FMM49_RS14970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FMM49_RS14975	COG2255	four-way junction helicase activity
FMM49_RS14980	COG1595	DNA-templated transcription, initiation
FMM49_RS15000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FMM49_RS15055	COG2986	histidine ammonia-lyase
FMM49_RS15065	COG1024	Enoyl-CoA hydratase
FMM49_RS15070	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FMM49_RS15080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FMM49_RS15095	COG0768	penicillin binding
FMM49_RS15100	COG0424	maF-like protein
FMM49_RS15140	COG4770	biotin carboxylase activity
FMM49_RS15145	COG0702	epimerase
FMM49_RS15180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FMM49_RS15215	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS15220	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS15235	COG1595	DNA-templated transcription, initiation
FMM49_RS15240	COG0745	RESPONSE REGULATOR receiver
FMM49_RS15245	COG2205	protein histidine kinase activity
FMM49_RS15270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FMM49_RS15285	COG0583	DNA-binding transcription factor activity
FMM49_RS15290	COG2814	Major facilitator Superfamily
FMM49_RS15320	COG1079	Belongs to the binding-protein-dependent transport system permease family
FMM49_RS15325	COG4603	Belongs to the binding-protein-dependent transport system permease family
FMM49_RS15330	COG3845	ABC transporter
FMM49_RS15335	COG1744	ABC transporter substrate-binding protein PnrA-like
FMM49_RS15340	COG1473	amidohydrolase
FMM49_RS15340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FMM49_RS15350	COG2089	acid synthase
FMM49_RS15355	COG1083	cytidylyl-transferase
FMM49_RS15365	COG1216	Glycosyl transferase, family 2
FMM49_RS15375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FMM49_RS15410	COG3265	gluconokinase activity
FMM49_RS15415	COG2186	Transcriptional regulator
FMM49_RS15440	COG3961	Belongs to the TPP enzyme family
FMM49_RS15445	COG1846	Transcriptional regulator
FMM49_RS15470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FMM49_RS15480	COG2009	succinate dehydrogenase
FMM49_RS15490	COG1053	succinate dehydrogenase
FMM49_RS15495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FMM49_RS15515	COG1309	transcriptional regulator
FMM49_RS15525	COG1404	Belongs to the peptidase S8 family
FMM49_RS15545	COG1295	ribonuclease BN
FMM49_RS15550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FMM49_RS15575	COG0180	Tryptophanyl-tRNA synthetase
FMM49_RS15585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FMM49_RS15590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FMM49_RS15595	COG0754	glutathionylspermidine amidase activity
FMM49_RS15610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FMM49_RS15615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FMM49_RS15620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FMM49_RS15645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FMM49_RS15650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FMM49_RS15660	COG1396	sequence-specific DNA binding
FMM49_RS15675	COG2197	response regulator
FMM49_RS15690	COG4585	Histidine kinase
FMM49_RS15700	COG4176	ABC-type proline glycine betaine transport system permease component
FMM49_RS15710	COG4175	Glycine betaine
FMM49_RS15710	COG0517	IMP dehydrogenase activity
FMM49_RS15720	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS15745	COG1476	TRANSCRIPTIONal
FMM49_RS15770	COG0039	L-malate dehydrogenase activity
FMM49_RS15805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FMM49_RS15810	COG1714	RDD family
FMM49_RS15820	COG0138	bifunctional purine biosynthesis protein purh
FMM49_RS15850	COG0045	succinate-CoA ligase (ADP-forming) activity
FMM49_RS15865	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FMM49_RS15870	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FMM49_RS15875	COG0714	Associated with various cellular activities
FMM49_RS15890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FMM49_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS15960	COG0789	Transcriptional regulator
FMM49_RS15990	COG1309	transcriptional regulator
FMM49_RS16000	COG2197	response regulator
FMM49_RS16015	COG0515	serine threonine protein kinase
FMM49_RS16015	COG2815	serine threonine protein kinase
FMM49_RS16060	COG2084	Dehydrogenase
FMM49_RS16075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FMM49_RS16075	COG0519	Catalyzes the synthesis of GMP from XMP
FMM49_RS16095	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS16100	COG0515	serine threonine protein kinase
FMM49_RS16115	COG2197	response regulator
FMM49_RS16120	COG4585	Histidine kinase
FMM49_RS16170	COG1131	(ABC) transporter
FMM49_RS16200	COG4821	SIS domain
FMM49_RS16210	COG0259	pyridoxamine-phosphate oxidase activity
FMM49_RS16230	COG1309	transcriptional regulator
FMM49_RS16235	COG1024	Enoyl-CoA hydratase
FMM49_RS16240	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS16255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FMM49_RS16290	COG2124	cytochrome p450
FMM49_RS16300	COG5006	permease, DMT superfamily
FMM49_RS16305	COG0583	DNA-binding transcription factor activity
FMM49_RS16310	COG0277	FAD linked oxidase domain protein
FMM49_RS16310	COG0247	lactate metabolic process
FMM49_RS16320	COG2378	regulation of single-species biofilm formation
FMM49_RS16325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FMM49_RS16360	COG0667	Aldo Keto reductase
FMM49_RS16395	COG2252	PERMEase
FMM49_RS16405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FMM49_RS16425	COG2814	Major facilitator Superfamily
FMM49_RS16435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FMM49_RS16440	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FMM49_RS16460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS16465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS16470	COG1120	ATPase activity
FMM49_RS16475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FMM49_RS16495	COG1061	Type III restriction enzyme res subunit
FMM49_RS16510	COG3973	AAA domain
FMM49_RS16515	COG3142	Participates in the control of copper homeostasis
FMM49_RS16550	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FMM49_RS16555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FMM49_RS16565	COG1115	amino acid carrier protein
FMM49_RS16570	COG4221	oxidoreductase activity
FMM49_RS16580	COG1278	Cold shock
FMM49_RS16595	COG0463	Glycosyl transferase, family 2
FMM49_RS16620	COG1940	carbohydrate kinase activity
FMM49_RS16625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FMM49_RS16650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FMM49_RS16700	COG3708	Transcriptional regulator
FMM49_RS16700	COG2207	Transcriptional regulator
FMM49_RS16715	COG3842	ATPase activity
FMM49_RS16725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FMM49_RS16740	COG0215	cysteine-tRNA ligase activity
FMM49_RS16745	COG3467	pyridoxamine 5'-phosphate
FMM49_RS16750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FMM49_RS16755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FMM49_RS16760	COG1329	Transcriptional regulator
FMM49_RS16775	COG5002	protein histidine kinase activity
FMM49_RS16795	COG0367	asparagine synthase
FMM49_RS16800	COG0588	phosphoglycerate mutase activity
FMM49_RS16815	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS16830	COG0667	Aldo Keto reductase
FMM49_RS16850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FMM49_RS16870	COG0456	acetyltransferase
FMM49_RS16875	COG0737	Belongs to the 5'-nucleotidase family
FMM49_RS16920	COG0702	epimerase
FMM49_RS16935	COG0745	RESPONSE REGULATOR receiver
FMM49_RS16945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FMM49_RS16950	COG1609	Transcriptional regulator
FMM49_RS16955	COG0745	RESPONSE REGULATOR receiver
FMM49_RS16990	COG2897	thiosulfate sulfurtransferase activity
FMM49_RS17010	COG3485	protocatechuate 3,4-dioxygenase
FMM49_RS17015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS17020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FMM49_RS17030	COG0735	belongs to the Fur family
FMM49_RS17035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FMM49_RS17040	COG1490	D-aminoacyl-tRNA deacylase activity
FMM49_RS17055	COG4552	Acetyltransferase involved in intracellular survival and related
FMM49_RS17070	COG1733	regulation of RNA biosynthetic process
FMM49_RS17085	COG2890	protein-(glutamine-N5) methyltransferase activity
FMM49_RS17095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FMM49_RS17115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FMM49_RS17125	COG1733	regulation of RNA biosynthetic process
FMM49_RS17130	COG0604	alcohol dehydrogenase
FMM49_RS17165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FMM49_RS17185	COG0306	phosphate transporter
FMM49_RS17195	COG1937	Protein conserved in bacteria
FMM49_RS17215	COG0277	FAD linked oxidase domain protein
FMM49_RS17225	COG0671	phosphoesterase, PA-phosphatase related
FMM49_RS17230	COG0791	NLP P60 protein
FMM49_RS17310	COG0180	Tryptophanyl-tRNA synthetase
FMM49_RS17315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FMM49_RS17335	COG0659	secondary active sulfate transmembrane transporter activity
FMM49_RS17340	COG0308	aminopeptidase N
FMM49_RS17345	COG2226	methyltransferase
FMM49_RS17375	COG0129	dihydroxy-acid dehydratase activity
FMM49_RS17385	COG1082	Xylose isomerase domain protein TIM barrel
FMM49_RS17390	COG0248	Ppx GppA phosphatase
FMM49_RS17410	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FMM49_RS17425	COG0671	phosphoesterase, PA-phosphatase related
FMM49_RS17435	COG1194	a g-specific adenine glycosylase
FMM49_RS17440	COG1595	DNA-templated transcription, initiation
FMM49_RS17450	COG0745	RESPONSE REGULATOR receiver
FMM49_RS17455	COG2205	protein histidine kinase activity
FMM49_RS17460	COG0346	lactoylglutathione lyase activity
FMM49_RS17465	COG2207	Transcriptional regulator
FMM49_RS17465	COG4753	response regulator
FMM49_RS17480	COG0739	heme binding
FMM49_RS17480	COG0741	lytic transglycosylase activity
FMM49_RS17480	COG1196	nuclear chromosome segregation
FMM49_RS17505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FMM49_RS17525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FMM49_RS17535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FMM49_RS17540	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FMM49_RS17555	COG0640	Transcriptional regulator
FMM49_RS17585	COG0649	NAD binding
FMM49_RS17600	COG3226	Transcriptional regulator
FMM49_RS17610	COG1309	transcriptional regulator
FMM49_RS17615	COG2814	Major facilitator Superfamily
FMM49_RS17625	COG1732	Glycine betaine
FMM49_RS17630	COG1174	glycine betaine transport
FMM49_RS17635	COG1174	glycine betaine transport
FMM49_RS17640	COG0517	IMP dehydrogenase activity
FMM49_RS17640	COG1125	glycine betaine transport
FMM49_RS17650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FMM49_RS17655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FMM49_RS17670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FMM49_RS17670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FMM49_RS17680	COG0302	gtp cyclohydrolase
FMM49_RS17695	COG0037	tRNA processing
FMM49_RS17705	COG2027	D-alanyl-D-alanine carboxypeptidase
FMM49_RS17710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FMM49_RS17725	COG0393	Putative heavy-metal-binding
FMM49_RS17730	COG0789	Transcriptional regulator
FMM49_RS17770	COG0655	NAD(P)H dehydrogenase (quinone) activity
FMM49_RS17775	COG0076	glutamate decarboxylase activity
FMM49_RS17795	COG2318	DinB family
FMM49_RS17800	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS17820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FMM49_RS17830	COG0254	rRNA binding
FMM49_RS17840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FMM49_RS17845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FMM49_RS17855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FMM49_RS17855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FMM49_RS17870	COG3655	Transcriptional regulator
FMM49_RS17875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FMM49_RS17875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FMM49_RS17880	COG0657	acetylesterase activity
FMM49_RS17885	COG1309	transcriptional regulator
FMM49_RS17895	COG1349	DNA-binding transcription factor activity
FMM49_RS17930	COG2197	response regulator
FMM49_RS17935	COG0584	glycerophosphoryl diester phosphodiesterase
FMM49_RS17960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FMM49_RS17970	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FMM49_RS17995	COG1132	(ABC) transporter
FMM49_RS18000	COG2366	antibiotic biosynthetic process
FMM49_RS18015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FMM49_RS18020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FMM49_RS18030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FMM49_RS18030	COG1754	DNA topoisomerase type I activity
FMM49_RS18050	COG2890	protein-(glutamine-N5) methyltransferase activity
FMM49_RS18060	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FMM49_RS18070	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS18075	COG1205	dead DEAH box helicase
FMM49_RS18075	COG1111	helicase
FMM49_RS18085	COG1917	Cupin 2, conserved barrel domain protein
FMM49_RS18150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FMM49_RS18155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FMM49_RS18165	COG2267	carboxylic ester hydrolase activity
FMM49_RS18190	COG2957	Belongs to the agmatine deiminase family
FMM49_RS18200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FMM49_RS18225	COG0003	Pfam Anion-transporting ATPase
FMM49_RS18235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FMM49_RS18245	COG1408	metallophosphoesterase
FMM49_RS18290	COG2268	Band 7 protein
FMM49_RS18295	COG4106	trans-aconitate 2-methyltransferase activity
FMM49_RS18305	COG1819	glycosyl
FMM49_RS18315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FMM49_RS18320	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS18325	COG2030	dehydratase
FMM49_RS18345	COG0515	serine threonine protein kinase
FMM49_RS18350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FMM49_RS18360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FMM49_RS18415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FMM49_RS18465	COG1357	PFAM Pentapeptide repeats (8 copies)
FMM49_RS18480	COG1595	DNA-templated transcription, initiation
FMM49_RS18500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FMM49_RS18505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FMM49_RS18540	COG2249	NAD(P)H dehydrogenase (quinone) activity
FMM49_RS18545	COG1595	DNA-templated transcription, initiation
FMM49_RS18565	COG0402	S-adenosylhomocysteine deaminase activity
FMM49_RS18595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FMM49_RS18600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FMM49_RS18605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FMM49_RS18610	COG1609	Transcriptional regulator
FMM49_RS18620	COG1309	transcriptional regulator
FMM49_RS18635	COG0488	(ABC) transporter
FMM49_RS18650	COG4552	Acetyltransferase involved in intracellular survival and related
FMM49_RS18655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FMM49_RS18660	COG0463	Glycosyl transferase, family 2
FMM49_RS18670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FMM49_RS18690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FMM49_RS18700	COG1940	carbohydrate kinase activity
FMM49_RS18705	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FMM49_RS18740	COG0523	cobalamin synthesis protein
FMM49_RS18775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FMM49_RS18800	COG0657	acetylesterase activity
FMM49_RS18840	COG0640	Transcriptional regulator
FMM49_RS18855	COG1191	sigma factor activity
FMM49_RS18860	COG1191	sigma factor activity
FMM49_RS18870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS18890	COG1595	DNA-templated transcription, initiation
FMM49_RS18925	COG0110	maltose O-acetyltransferase activity
FMM49_RS18975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FMM49_RS18985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS19025	COG0477	Major facilitator Superfamily
FMM49_RS19030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FMM49_RS19040	COG2205	protein histidine kinase activity
FMM49_RS19045	COG0745	RESPONSE REGULATOR receiver
FMM49_RS19070	COG2249	NAD(P)H dehydrogenase (quinone) activity
FMM49_RS19095	COG1609	Transcriptional regulator
FMM49_RS19175	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS19220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS19230	COG1595	DNA-templated transcription, initiation
FMM49_RS19265	COG0457	Tetratricopeptide repeat
FMM49_RS19290	COG2188	Transcriptional regulator
FMM49_RS19425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FMM49_RS19465	COG0006	proline dipeptidase activity
FMM49_RS19500	COG2372	response to copper ion
FMM49_RS19505	COG2837	iron assimilation
FMM49_RS19515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FMM49_RS19520	COG0561	phosphatase activity
FMM49_RS19550	COG0789	Transcriptional regulator
FMM49_RS19565	COG2186	Transcriptional regulator
FMM49_RS19570	COG2807	transmembrane transport
FMM49_RS19580	COG0789	Transcriptional regulator
FMM49_RS19620	COG1131	(ABC) transporter
FMM49_RS19640	COG0789	Transcriptional regulator
FMM49_RS19655	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
FMM49_RS19680	COG0501	Belongs to the peptidase M48B family
FMM49_RS19690	COG0561	phosphatase activity
FMM49_RS19695	COG0739	heme binding
FMM49_RS19705	COG4988	ABC transporter
FMM49_RS19710	COG1294	oxidase, subunit
FMM49_RS19715	COG1271	oxidase subunit
FMM49_RS19725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FMM49_RS19730	COG1609	Transcriptional regulator
FMM49_RS19735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FMM49_RS19755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FMM49_RS19780	COG0662	Cupin 2, conserved barrel domain protein
FMM49_RS19785	COG1950	PFAM Membrane protein of
FMM49_RS19795	COG0626	cystathionine gamma-synthase activity
FMM49_RS19835	COG2814	Major facilitator Superfamily
FMM49_RS19840	COG1846	Transcriptional regulator
FMM49_RS19875	COG0789	Transcriptional regulator
FMM49_RS19875	COG4978	Transcriptional regulator
FMM49_RS19900	COG0242	peptide deformylase activity
FMM49_RS19905	COG1309	transcriptional regulator
FMM49_RS19920	COG0305	Participates in initiation and elongation during chromosome replication
FMM49_RS19925	COG0534	Mate efflux family protein
FMM49_RS19935	COG0359	binds to the 23S rRNA
FMM49_RS19940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FMM49_RS19945	COG0629	single-stranded DNA binding
FMM49_RS19950	COG0360	Binds together with S18 to 16S ribosomal RNA
FMM49_RS19975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FMM49_RS19980	COG1695	Transcriptional regulator
FMM49_RS20000	COG0617	tRNA 3'-terminal CCA addition
FMM49_RS20025	COG1595	DNA-templated transcription, initiation
FMM49_RS20035	COG0492	ferredoxin-NADP+ reductase activity
FMM49_RS20040	COG3118	belongs to the thioredoxin family
FMM49_RS20055	COG1192	Involved in chromosome partitioning
FMM49_RS20060	COG0357	Ribosomal RNA small subunit methyltransferase G
FMM49_RS20070	COG0706	membrane insertase activity
FMM49_RS20075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FMM49_RS20085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FMM49_RS20090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FMM49_RS20095	COG0592	DNA-directed DNA polymerase activity
FMM49_RS20100	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FMM49_RS20105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FMM49_RS20110	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FMM49_RS20120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FMM49_RS20145	COG0515	serine threonine protein kinase
FMM49_RS20170	COG0705	Rhomboid family
FMM49_RS20185	COG3764	Sortase (surface protein transpeptidase)
FMM49_RS20200	COG3764	Sortase (surface protein transpeptidase)
FMM49_RS20205	COG3764	Sortase (surface protein transpeptidase)
FMM49_RS20210	COG0515	serine threonine protein kinase
FMM49_RS20215	COG0768	penicillin binding
FMM49_RS20230	COG1716	ATPase activity
FMM49_RS20235	COG1716	ATPase activity
FMM49_RS20245	COG0583	DNA-binding transcription factor activity
FMM49_RS20255	COG4585	Histidine kinase
FMM49_RS20260	COG2197	response regulator
FMM49_RS20265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FMM49_RS20270	COG1733	regulation of RNA biosynthetic process
FMM49_RS20305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FMM49_RS20310	COG2151	metal-sulfur cluster biosynthetic enzyme
FMM49_RS20315	COG3396	Phenylacetate-CoA oxygenase
FMM49_RS20320	COG3460	Phenylacetate-CoA oxygenase
FMM49_RS20325	COG3396	Phenylacetate-CoA oxygenase
FMM49_RS20385	COG1250	3-hydroxyacyl-CoA dehydrogenase
FMM49_RS20390	COG1309	transcriptional regulator
FMM49_RS20395	COG1522	sequence-specific DNA binding
FMM49_RS20415	COG0746	molybdenum cofactor guanylyltransferase activity
FMM49_RS20420	COG0303	'Molybdopterin
FMM49_RS20425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FMM49_RS20430	COG3321	synthase
FMM49_RS20430	COG0604	alcohol dehydrogenase
FMM49_RS20430	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS20445	COG0515	serine threonine protein kinase
FMM49_RS20450	COG0515	serine threonine protein kinase
FMM49_RS20475	COG0022	dehydrogenase e1 component
FMM49_RS20480	COG0508	dehydrogenase complex catalyzes the overall conversion of
FMM49_RS20535	COG0477	Major facilitator Superfamily
FMM49_RS20560	COG1802	Transcriptional regulator
FMM49_RS20625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS20640	COG3629	intracellular signal transduction
FMM49_RS20640	COG3903	Transcriptional regulator
FMM49_RS20645	COG1362	aminopeptidase activity
FMM49_RS20650	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS20665	COG1741	Belongs to the pirin family
FMM49_RS20670	COG0628	permease
FMM49_RS20680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FMM49_RS20695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FMM49_RS20700	COG2226	methyltransferase
FMM49_RS20725	COG1174	glycine betaine transport
FMM49_RS20730	COG1174	glycine betaine transport
FMM49_RS20740	COG0517	IMP dehydrogenase activity
FMM49_RS20740	COG1125	glycine betaine transport
FMM49_RS20830	COG1316	TRANSCRIPTIONal
FMM49_RS20870	COG0477	Major facilitator Superfamily
FMM49_RS20890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FMM49_RS20905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FMM49_RS20920	COG2197	response regulator
FMM49_RS20930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FMM49_RS20940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS20960	COG3629	intracellular signal transduction
FMM49_RS20970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FMM49_RS20985	COG0789	Transcriptional regulator
FMM49_RS21000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS21000	COG3321	synthase
FMM49_RS21025	COG2319	Wd-40 repeat
FMM49_RS21025	COG5635	Nacht domain
FMM49_RS21080	COG0717	Belongs to the dCTP deaminase family
FMM49_RS21115	COG0247	lactate metabolic process
FMM49_RS21115	COG2181	nitrate reductase activity
FMM49_RS21120	COG0443	Heat shock 70 kDa protein
FMM49_RS21125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FMM49_RS21130	COG0484	heat shock protein binding
FMM49_RS21135	COG0789	Transcriptional regulator
FMM49_RS21155	COG0542	response to heat
FMM49_RS21190	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FMM49_RS21205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FMM49_RS21210	COG0191	fructose-bisphosphate aldolase activity
FMM49_RS21220	COG3483	tryptophan 2,3-dioxygenase activity
FMM49_RS21225	COG3844	kynureninase activity
FMM49_RS21230	COG0657	acetylesterase activity
FMM49_RS21235	COG4585	Histidine kinase
FMM49_RS21240	COG2197	response regulator
FMM49_RS21255	COG3559	Exporter of polyketide antibiotics
FMM49_RS21260	COG1131	(ABC) transporter
FMM49_RS21275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FMM49_RS21290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FMM49_RS21315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FMM49_RS21335	COG0693	protein deglycase activity
FMM49_RS21345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FMM49_RS21350	COG1802	Transcriptional regulator
FMM49_RS21365	COG0151	Belongs to the GarS family
FMM49_RS21380	COG0583	DNA-binding transcription factor activity
FMM49_RS21385	COG2814	Major facilitator Superfamily
FMM49_RS21390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FMM49_RS21405	COG3850	Histidine kinase
FMM49_RS21440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FMM49_RS21445	COG0047	phosphoribosylformylglycinamidine synthase activity
FMM49_RS21450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FMM49_RS21510	COG1643	Atp-dependent helicase
FMM49_RS21545	COG0513	Belongs to the DEAD box helicase family
FMM49_RS21595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FMM49_RS21670	COG2814	Major facilitator Superfamily
FMM49_RS21675	COG0667	Aldo Keto reductase
FMM49_RS21710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FMM49_RS21715	COG0579	oxidoreductase
FMM49_RS21740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FMM49_RS21775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FMM49_RS21780	COG0123	including yeast histone deacetylase and acetoin utilization protein
FMM49_RS21835	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FMM49_RS21840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FMM49_RS21845	COG0181	hydroxymethylbilane synthase activity
FMM49_RS21850	COG1648	precorrin-2 dehydrogenase activity
FMM49_RS21850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FMM49_RS21855	COG0113	porphobilinogen synthase activity
FMM49_RS21890	COG2814	Major facilitator Superfamily
FMM49_RS21915	COG0018	arginyl-trna synthetase
FMM49_RS21920	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FMM49_RS21985	COG1690	Belongs to the RtcB family
FMM49_RS22005	COG1742	UPF0060 membrane protein
FMM49_RS22015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FMM49_RS22030	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS22045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FMM49_RS22055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FMM49_RS22060	COG0406	alpha-ribazole phosphatase activity
FMM49_RS22075	COG0785	Cytochrome C biogenesis protein
FMM49_RS22080	COG1333	cytochrome c biogenesis protein
FMM49_RS22085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FMM49_RS22130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FMM49_RS22135	COG0109	protoheme IX farnesyltransferase activity
FMM49_RS22150	COG0163	prenyltransferase activity
FMM49_RS22165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FMM49_RS22180	COG1823	symporter activity
FMM49_RS22195	COG1309	transcriptional regulator
FMM49_RS22220	COG1278	Cold shock
FMM49_RS22225	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FMM49_RS22230	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FMM49_RS22240	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FMM49_RS22255	COG2226	methyltransferase
FMM49_RS22295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FMM49_RS22300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FMM49_RS22305	COG0649	NAD binding
FMM49_RS22315	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FMM49_RS22320	COG1034	ATP synthesis coupled electron transport
FMM49_RS22325	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FMM49_RS22330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FMM49_RS22335	COG0839	Belongs to the complex I subunit 6 family
FMM49_RS22340	COG0713	ATP synthesis coupled electron transport
FMM49_RS22345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FMM49_RS22355	COG1007	ATP synthesis coupled electron transport
FMM49_RS22385	COG0492	ferredoxin-NADP+ reductase activity
FMM49_RS22390	COG0142	geranyltranstransferase activity
FMM49_RS22410	COG2234	aminopeptidase activity
FMM49_RS22410	COG4935	Belongs to the peptidase S8 family
FMM49_RS22420	COG1013	pyruvate-flavodoxin oxidoreductase activity
FMM49_RS22425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FMM49_RS22425	COG0674	pyruvate-flavodoxin oxidoreductase activity
FMM49_RS22435	COG4585	Histidine kinase
FMM49_RS22440	COG4585	Histidine kinase
FMM49_RS22460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FMM49_RS22465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FMM49_RS22470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FMM49_RS22475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FMM49_RS22480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FMM49_RS22485	COG0839	Belongs to the complex I subunit 6 family
FMM49_RS22490	COG0713	ATP synthesis coupled electron transport
FMM49_RS22495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FMM49_RS22505	COG1007	ATP synthesis coupled electron transport
FMM49_RS22510	COG0501	Belongs to the peptidase M48B family
FMM49_RS22515	COG3304	Inner membrane component domain
FMM49_RS22525	COG1666	GTP binding
FMM49_RS22535	COG0702	epimerase
FMM49_RS22555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FMM49_RS22560	COG2030	dehydratase
FMM49_RS22570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FMM49_RS22575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FMM49_RS22580	COG0436	Aminotransferase
FMM49_RS22600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FMM49_RS22605	COG0081	regulation of translation
FMM49_RS22615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FMM49_RS22620	COG0222	ribosome binding
FMM49_RS22625	COG0085	RNA polymerase activity
FMM49_RS22630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FMM49_RS22640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FMM49_RS22645	COG0049	tRNA binding
FMM49_RS22650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FMM49_RS22655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FMM49_RS22660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FMM49_RS22685	COG0051	transcription antitermination factor activity, RNA binding
FMM49_RS22690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FMM49_RS22695	COG0088	Forms part of the polypeptide exit tunnel
FMM49_RS22700	COG0089	rRNA binding
FMM49_RS22705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FMM49_RS22710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FMM49_RS22715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FMM49_RS22720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FMM49_RS22725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FMM49_RS22730	COG0255	Belongs to the universal ribosomal protein uL29 family
FMM49_RS22735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FMM49_RS22740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FMM49_RS22745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FMM49_RS22750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FMM49_RS22755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FMM49_RS22760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FMM49_RS22765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FMM49_RS22770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FMM49_RS22775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FMM49_RS22780	COG1841	ribosomal large subunit assembly
FMM49_RS22785	COG0200	Binds to the 23S rRNA
FMM49_RS22795	COG0563	adenylate kinase activity
FMM49_RS22805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FMM49_RS22810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FMM49_RS22815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FMM49_RS22820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FMM49_RS22825	COG0202	RNA polymerase activity
FMM49_RS22830	COG0203	ribosomal protein L17
FMM49_RS22835	COG0101	tRNA pseudouridine synthase activity
FMM49_RS22845	COG0488	(ABC) transporter
FMM49_RS22855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FMM49_RS22860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FMM49_RS22865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FMM49_RS22875	COG1072	(Pantothenic acid kinase))
FMM49_RS22880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FMM49_RS22885	COG0736	holo-[acyl-carrier-protein] synthase activity
FMM49_RS22895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FMM49_RS22905	COG0802	atpase or kinase
FMM49_RS22930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FMM49_RS22950	COG0772	Belongs to the SEDS family
FMM49_RS22955	COG1316	TRANSCRIPTIONal
FMM49_RS22960	COG2205	protein histidine kinase activity
FMM49_RS22965	COG0745	RESPONSE REGULATOR receiver
FMM49_RS22970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FMM49_RS22975	COG0459	protein refolding
FMM49_RS23000	COG1609	Transcriptional regulator
FMM49_RS23010	COG4221	oxidoreductase activity
FMM49_RS23020	COG0583	DNA-binding transcription factor activity
FMM49_RS23030	COG2197	response regulator
FMM49_RS23035	COG1595	DNA-templated transcription, initiation
FMM49_RS23050	COG0516	GMP reductase activity
FMM49_RS23065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FMM49_RS23085	COG0477	Major facilitator Superfamily
FMM49_RS23090	COG0583	DNA-binding transcription factor activity
FMM49_RS23100	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS23105	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS23120	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS23125	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS23135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FMM49_RS23140	COG1024	Enoyl-CoA hydratase
FMM49_RS23150	COG2072	flavoprotein involved in K transport
FMM49_RS23255	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS23265	COG1309	transcriptional regulator
FMM49_RS23275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FMM49_RS23275	COG0515	serine threonine protein kinase
FMM49_RS23295	COG1024	Enoyl-CoA hydratase
FMM49_RS23370	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FMM49_RS23390	COG0492	ferredoxin-NADP+ reductase activity
FMM49_RS23430	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FMM49_RS23480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FMM49_RS23505	COG1686	Belongs to the peptidase S11 family
FMM49_RS23515	COG0640	Transcriptional regulator
FMM49_RS23540	COG2205	protein histidine kinase activity
FMM49_RS23570	COG0514	ATP-dependent DNA helicase (RecQ)
FMM49_RS23590	COG1595	DNA-templated transcription, initiation
FMM49_RS23835	COG1674	ftsk spoiiie
FMM49_RS24020	COG5280	Phage tail tape measure protein TP901
FMM49_RS24020	COG3953	SLT domain
FMM49_RS24110	COG0659	secondary active sulfate transmembrane transporter activity
FMM49_RS24125	COG0477	Major facilitator Superfamily
FMM49_RS24195	COG1309	transcriptional regulator
FMM49_RS24225	COG1846	Transcriptional regulator
FMM49_RS24245	COG1247	-acetyltransferase
FMM49_RS24255	COG1349	DNA-binding transcription factor activity
FMM49_RS24275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FMM49_RS24290	COG3191	aminopeptidase activity
FMM49_RS24305	COG1473	amidohydrolase
FMM49_RS24330	COG0730	response to heat
FMM49_RS24335	COG2188	Transcriptional regulator
FMM49_RS24340	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FMM49_RS24345	COG0477	Major facilitator Superfamily
FMM49_RS24370	COG1970	mechanosensitive ion channel activity
FMM49_RS24375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FMM49_RS24385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FMM49_RS24390	COG3263	regulation of cellular component size
FMM49_RS24395	COG2366	antibiotic biosynthetic process
FMM49_RS24400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FMM49_RS24405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FMM49_RS24415	COG0315	cyclic pyranopterin monophosphate synthase activity
FMM49_RS24425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FMM49_RS24445	COG0739	heme binding
FMM49_RS24450	COG1609	Transcriptional regulator
FMM49_RS24460	COG1175	transmembrane transport
FMM49_RS24465	COG0395	ABC-type sugar transport system, permease component
FMM49_RS24485	COG1819	glycosyl
FMM49_RS24490	COG0789	Transcriptional regulator
FMM49_RS24500	COG2205	protein histidine kinase activity
FMM49_RS24520	COG0708	Exodeoxyribonuclease III
FMM49_RS24580	COG1733	regulation of RNA biosynthetic process
FMM49_RS24585	COG0251	oxidation-reduction process
FMM49_RS24590	COG1335	isochorismatase
FMM49_RS24600	COG2072	flavoprotein involved in K transport
FMM49_RS24605	COG2267	carboxylic ester hydrolase activity
FMM49_RS24610	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS24625	COG4946	Tricorn protease homolog
FMM49_RS24625	COG0793	Belongs to the peptidase S41A family
FMM49_RS24635	COG2409	Drug exporters of the RND superfamily
FMM49_RS24650	COG0310	cobalt ion transport
FMM49_RS24660	COG1122	ATPase activity
FMM49_RS24665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FMM49_RS24675	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS24685	COG0768	penicillin binding
FMM49_RS24710	COG0084	hydrolase, TatD family'
FMM49_RS24715	COG3583	domain protein
FMM49_RS24715	COG3584	3D domain protein
FMM49_RS24720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FMM49_RS24725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FMM49_RS24735	COG0488	(ABC) transporter
FMM49_RS24765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FMM49_RS24770	COG2197	response regulator
FMM49_RS24790	COG4106	trans-aconitate 2-methyltransferase activity
FMM49_RS24800	COG1309	transcriptional regulator
FMM49_RS24810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FMM49_RS24825	COG0193	aminoacyl-tRNA hydrolase activity
FMM49_RS24830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FMM49_RS24835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FMM49_RS24840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FMM49_RS24855	COG4585	Histidine kinase
FMM49_RS24880	COG1316	TRANSCRIPTIONal
FMM49_RS24890	COG2814	Major facilitator Superfamily
FMM49_RS24905	COG3896	Chloramphenicol phosphotransferase-like protein
FMM49_RS24930	COG2814	Major facilitator Superfamily
FMM49_RS24935	COG0583	DNA-binding transcription factor activity
FMM49_RS24945	COG2124	cytochrome p450
FMM49_RS24960	COG0148	phosphopyruvate hydratase activity
FMM49_RS24985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FMM49_RS24990	COG0577	efflux transmembrane transporter activity
FMM49_RS24995	COG1136	(ABC) transporter
FMM49_RS25065	COG0183	Belongs to the thiolase family
FMM49_RS25070	COG2755	lipolytic protein G-D-S-L family
FMM49_RS25085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FMM49_RS25100	COG1609	Transcriptional regulator
FMM49_RS25115	COG0596	Alpha beta hydrolase
FMM49_RS25140	COG0019	diaminopimelate decarboxylase activity
FMM49_RS25145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FMM49_RS25145	COG2022	thiamine diphosphate biosynthetic process
FMM49_RS25160	COG3938	Belongs to the proline racemase family
FMM49_RS25170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FMM49_RS25175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FMM49_RS25180	COG0402	S-adenosylhomocysteine deaminase activity
FMM49_RS25185	COG1228	amidohydrolase
FMM49_RS25195	COG2197	response regulator
FMM49_RS25205	COG3963	phosphatidate phosphatase activity
FMM49_RS25210	COG1191	sigma factor activity
FMM49_RS25215	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS25245	COG3104	oligopeptide transport
FMM49_RS25250	COG0745	RESPONSE REGULATOR receiver
FMM49_RS25255	COG5002	protein histidine kinase activity
FMM49_RS25290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FMM49_RS25320	COG1316	TRANSCRIPTIONal
FMM49_RS25325	COG1607	acyl-coa hydrolase
FMM49_RS25345	COG0477	Major facilitator Superfamily
FMM49_RS25390	COG0778	Nitroreductase
FMM49_RS25390	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FMM49_RS25395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FMM49_RS25430	COG1620	l-lactate permease
FMM49_RS25435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FMM49_RS25440	COG2835	tetraacyldisaccharide 4'-kinase activity
FMM49_RS25450	COG1482	cell wall glycoprotein biosynthetic process
FMM49_RS25460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FMM49_RS25460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FMM49_RS25460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FMM49_RS25470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FMM49_RS25510	COG0714	Associated with various cellular activities
FMM49_RS25530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FMM49_RS25535	COG0745	RESPONSE REGULATOR receiver
FMM49_RS25540	COG5000	phosphorelay sensor kinase activity
FMM49_RS25540	COG5002	protein histidine kinase activity
FMM49_RS25545	COG0823	Involved in the tonB-independent uptake of proteins
FMM49_RS25555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FMM49_RS25560	COG2197	response regulator
FMM49_RS25575	COG0653	protein targeting
FMM49_RS25605	COG1134	teichoic acid transport
FMM49_RS25615	COG1309	transcriptional regulator
FMM49_RS25630	COG0463	Glycosyl transferase, family 2
FMM49_RS25640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FMM49_RS25645	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS25650	COG0463	Glycosyl transferase, family 2
FMM49_RS25660	COG1215	transferase activity, transferring glycosyl groups
FMM49_RS25665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FMM49_RS25675	COG0395	ABC-type sugar transport system, permease component
FMM49_RS25680	COG1175	transmembrane transport
FMM49_RS25685	COG1653	transport
FMM49_RS25690	COG1674	ftsk spoiiie
FMM49_RS25695	COG0515	serine threonine protein kinase
FMM49_RS25700	COG0515	serine threonine protein kinase
FMM49_RS25705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FMM49_RS25720	COG2884	Cell division ATP-binding protein ftsE
FMM49_RS25725	COG2177	Part of the ABC transporter FtsEX involved in
FMM49_RS25730	COG0793	Belongs to the peptidase S41A family
FMM49_RS25735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FMM49_RS25780	COG2223	nitrite transmembrane transporter activity
FMM49_RS25810	COG3973	AAA domain
FMM49_RS25820	COG0776	regulation of translation
FMM49_RS25825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FMM49_RS25830	COG1678	Uncharacterized ACR, COG1678
FMM49_RS25835	COG0583	DNA-binding transcription factor activity
FMM49_RS25845	COG2814	Major facilitator Superfamily
FMM49_RS25865	COG1175	transmembrane transport
FMM49_RS25870	COG0395	ABC-type sugar transport system, permease component
FMM49_RS25875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FMM49_RS25890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FMM49_RS25905	COG2201	protein-glutamate methylesterase activity
FMM49_RS25910	COG0477	Major facilitator Superfamily
FMM49_RS25930	COG1732	Glycine betaine
FMM49_RS25935	COG1174	glycine betaine transport
FMM49_RS25945	COG1174	glycine betaine transport
FMM49_RS25955	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FMM49_RS25960	COG0277	FAD linked oxidase domain protein
FMM49_RS25965	COG0222	ribosome binding
FMM49_RS26010	COG1335	isochorismatase
FMM49_RS26020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FMM49_RS26030	COG1113	amino acid transport
FMM49_RS26045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS26050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FMM49_RS26070	COG1234	tRNA 3'-trailer cleavage
FMM49_RS26075	COG1263	PTS System
FMM49_RS26080	COG1263	PTS System
FMM49_RS26085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FMM49_RS26090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FMM49_RS26105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FMM49_RS26135	COG2205	protein histidine kinase activity
FMM49_RS26150	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FMM49_RS26160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FMM49_RS26190	COG2733	membrane
FMM49_RS26195	COG3764	Sortase (surface protein transpeptidase)
FMM49_RS26205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FMM49_RS26215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FMM49_RS26235	COG0706	membrane insertase activity
FMM49_RS26240	COG0179	Fumarylacetoacetate (FAA) hydrolase
FMM49_RS26250	COG4702	Belongs to the UPF0303 family
FMM49_RS26255	COG0673	inositol 2-dehydrogenase activity
FMM49_RS26270	COG2188	Transcriptional regulator
FMM49_RS26300	COG1840	ABC-type Fe3 transport system, periplasmic component
FMM49_RS26340	COG2186	Transcriptional regulator
FMM49_RS26370	COG3397	chitin binding
FMM49_RS26375	COG3397	chitin binding
FMM49_RS26390	COG1126	abc transporter atp-binding protein
FMM49_RS26395	COG0765	amino acid transport
FMM49_RS26400	COG0765	amino acid transport
FMM49_RS26415	COG0154	amidase activity
FMM49_RS26435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS26485	COG0588	phosphoglycerate mutase activity
FMM49_RS26550	COG5297	Belongs to the glycosyl hydrolase family 6
FMM49_RS26565	COG2910	NAD(P)H-binding
FMM49_RS26575	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FMM49_RS26580	COG4977	sequence-specific DNA binding
FMM49_RS26590	COG0589	response to stress
FMM49_RS26595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FMM49_RS26610	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS26625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FMM49_RS26630	COG1309	transcriptional regulator
FMM49_RS26640	COG1946	Acyl-CoA thioesterase
FMM49_RS26685	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FMM49_RS26695	COG0281	malic enzyme
FMM49_RS26700	COG1309	transcriptional regulator
FMM49_RS26705	COG1511	domain protein
FMM49_RS26710	COG1132	(ABC) transporter
FMM49_RS26745	COG1472	Belongs to the glycosyl hydrolase 3 family
FMM49_RS26760	COG1609	Transcriptional regulator
FMM49_RS26765	COG0673	inositol 2-dehydrogenase activity
FMM49_RS26780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FMM49_RS26800	COG0569	domain protein
FMM49_RS26800	COG0475	glutathione-regulated potassium exporter activity
FMM49_RS26810	COG0673	inositol 2-dehydrogenase activity
FMM49_RS26825	COG2814	Major facilitator Superfamily
FMM49_RS26830	COG1082	Xylose isomerase domain protein TIM barrel
FMM49_RS26835	COG0673	inositol 2-dehydrogenase activity
FMM49_RS26845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FMM49_RS26855	COG3718	enzyme involved in inositol metabolism
FMM49_RS26860	COG3962	Belongs to the TPP enzyme family
FMM49_RS26880	COG1131	(ABC) transporter
FMM49_RS26910	COG1077	Cell shape determining protein MreB Mrl
FMM49_RS27015	COG1160	GTP binding
FMM49_RS27020	COG0629	single-stranded DNA binding
FMM49_RS27045	COG2346	COG2346, Truncated hemoglobins
FMM49_RS27050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS27080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FMM49_RS27095	COG1486	melibiose metabolic process
FMM49_RS27100	COG0395	ABC-type sugar transport system, permease component
FMM49_RS27105	COG1175	transmembrane transport
FMM49_RS27115	COG1940	carbohydrate kinase activity
FMM49_RS27115	COG1846	Transcriptional regulator
FMM49_RS27145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FMM49_RS27150	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FMM49_RS27155	COG2080	2 iron, 2 sulfur cluster binding
FMM49_RS27185	COG0668	transmembrane transport
FMM49_RS27195	COG3291	Pkd domain containing protein
FMM49_RS27195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FMM49_RS27225	COG0583	DNA-binding transcription factor activity
FMM49_RS27230	COG4266	Belongs to the allantoicase family
FMM49_RS27250	COG2337	Toxic component of a toxin-antitoxin (TA) module
FMM49_RS27285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FMM49_RS27290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FMM49_RS27295	COG1113	amino acid transport
FMM49_RS27300	COG1113	amino acid transport
FMM49_RS27305	COG1268	BioY protein
FMM49_RS27315	COG0515	serine threonine protein kinase
FMM49_RS27320	COG1113	amino acid transport
FMM49_RS27335	COG4552	Acetyltransferase involved in intracellular survival and related
FMM49_RS27350	COG0475	glutathione-regulated potassium exporter activity
FMM49_RS27355	COG1136	(ABC) transporter
FMM49_RS27360	COG3594	Acyltransferase
FMM49_RS27385	COG0544	peptidyl-prolyl cis-trans isomerase activity
FMM49_RS27390	COG0740	serine-type endopeptidase activity
FMM49_RS27395	COG0740	serine-type endopeptidase activity
FMM49_RS27400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FMM49_RS27415	COG0525	valine-tRNA ligase activity
FMM49_RS27425	COG0768	penicillin binding
FMM49_RS27430	COG0285	dihydrofolate synthase activity
FMM49_RS27440	COG0105	UTP biosynthetic process
FMM49_RS27445	COG1077	Cell shape determining protein MreB Mrl
FMM49_RS27465	COG0772	Belongs to the SEDS family
FMM49_RS27475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FMM49_RS27480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS27480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS27505	COG1530	ribonuclease E activity
FMM49_RS27510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FMM49_RS27515	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FMM49_RS27520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FMM49_RS27525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FMM49_RS27535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FMM49_RS27550	COG0501	Belongs to the peptidase M48B family
FMM49_RS27565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FMM49_RS27575	COG0799	negative regulation of ribosome biogenesis
FMM49_RS27580	COG0588	phosphoglycerate mutase activity
FMM49_RS27630	COG0495	leucyl-tRNA aminoacylation
FMM49_RS27640	COG1307	EDD domain protein, DegV family
FMM49_RS27645	COG1596	polysaccharide export
FMM49_RS27645	COG1555	photosystem II stabilization
FMM49_RS27650	COG1234	tRNA 3'-trailer cleavage
FMM49_RS27655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FMM49_RS27660	COG1959	2 iron, 2 sulfur cluster binding
FMM49_RS27685	COG0268	Binds directly to 16S ribosomal RNA
FMM49_RS27690	COG0481	GTPase activity
FMM49_RS27700	COG1022	Amp-dependent synthetase and ligase
FMM49_RS27705	COG3437	response regulator, receiver
FMM49_RS27740	COG1420	regulation of RNA biosynthetic process
FMM49_RS27745	COG0484	heat shock protein binding
FMM49_RS27770	COG0537	adenosine 5'-monophosphoramidase activity
FMM49_RS27775	COG1234	tRNA 3'-trailer cleavage
FMM49_RS27785	COG4948	Mandelate Racemase Muconate Lactonizing
FMM49_RS27800	COG1486	melibiose metabolic process
FMM49_RS27805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FMM49_RS27815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FMM49_RS27825	COG2814	Major facilitator Superfamily
FMM49_RS27860	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS27865	COG0492	ferredoxin-NADP+ reductase activity
FMM49_RS27880	COG0475	glutathione-regulated potassium exporter activity
FMM49_RS27885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FMM49_RS27895	COG2723	6-phospho-beta-galactosidase activity
FMM49_RS27910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FMM49_RS27920	COG1381	Involved in DNA repair and RecF pathway recombination
FMM49_RS27925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FMM49_RS27935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FMM49_RS27940	COG1121	(ABC) transporter
FMM49_RS27950	COG0423	glycine-tRNA ligase activity
FMM49_RS27965	COG2197	response regulator
FMM49_RS27980	COG0667	Aldo Keto reductase
FMM49_RS27985	COG0477	Major facilitator Superfamily
FMM49_RS28005	COG0574	Belongs to the PEP-utilizing enzyme family
FMM49_RS28005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FMM49_RS28015	COG2175	clavaminate synthase activity
FMM49_RS28030	COG0395	ABC-type sugar transport system, permease component
FMM49_RS28035	COG1175	transmembrane transport
FMM49_RS28045	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS28050	COG0789	Transcriptional regulator
FMM49_RS28060	COG2814	Major facilitator Superfamily
FMM49_RS28090	COG3485	protocatechuate 3,4-dioxygenase
FMM49_RS28100	COG0531	amino acid
FMM49_RS28120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FMM49_RS28120	COG2146	nitrite reductase [NAD(P)H] activity
FMM49_RS28125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FMM49_RS28135	COG2197	response regulator
FMM49_RS28150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FMM49_RS28180	COG2382	esterase
FMM49_RS28220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FMM49_RS28235	COG0243	molybdopterin cofactor binding
FMM49_RS28245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FMM49_RS28260	COG0358	DNA primase activity
FMM49_RS28265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FMM49_RS28270	COG1070	Carbohydrate kinase
FMM49_RS28300	COG1834	amidinotransferase
FMM49_RS28325	COG2080	2 iron, 2 sulfur cluster binding
FMM49_RS28325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FMM49_RS28330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FMM49_RS28340	COG1077	Cell shape determining protein MreB Mrl
FMM49_RS28350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FMM49_RS28380	COG4981	capsule polysaccharide biosynthetic process
FMM49_RS28385	COG0500	methyltransferase
FMM49_RS28415	COG0477	Major facilitator Superfamily
FMM49_RS28425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FMM49_RS28435	COG2130	NADP-dependent
FMM49_RS28440	COG1764	response to oxidative stress
FMM49_RS28445	COG1609	Transcriptional regulator
FMM49_RS28455	COG1172	Belongs to the binding-protein-dependent transport system permease family
FMM49_RS28465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FMM49_RS28515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FMM49_RS28520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FMM49_RS28525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FMM49_RS28550	COG0789	Transcriptional regulator
FMM49_RS28555	COG0667	Aldo Keto reductase
FMM49_RS28570	COG2197	response regulator
FMM49_RS28575	COG4585	Histidine kinase
FMM49_RS28590	COG1309	transcriptional regulator
FMM49_RS28595	COG0477	Major facilitator Superfamily
FMM49_RS28610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FMM49_RS28665	COG0586	Pfam SNARE associated Golgi protein
FMM49_RS28670	COG4585	Histidine kinase
FMM49_RS28695	COG4948	Mandelate Racemase Muconate Lactonizing
FMM49_RS28720	COG2259	Doxx family
FMM49_RS28730	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FMM49_RS28745	COG1120	ATPase activity
FMM49_RS28810	COG1072	(Pantothenic acid kinase))
FMM49_RS28840	COG2259	Doxx family
FMM49_RS28865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FMM49_RS28870	COG3409	Peptidoglycan-binding domain 1 protein
FMM49_RS28870	COG0860	N-Acetylmuramoyl-L-alanine amidase
FMM49_RS28880	COG0456	acetyltransferase
FMM49_RS28915	COG0477	Major facilitator Superfamily
FMM49_RS28925	COG0667	Aldo Keto reductase
FMM49_RS28940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FMM49_RS28965	COG2124	cytochrome p450
FMM49_RS28970	COG0183	Belongs to the thiolase family
FMM49_RS28980	COG2318	DinB family
FMM49_RS29005	COG3845	ABC transporter
FMM49_RS29020	COG1657	PFAM Prenyltransferase squalene oxidase
FMM49_RS29040	COG0515	serine threonine protein kinase
FMM49_RS29050	COG1132	(ABC) transporter
FMM49_RS29055	COG1132	(ABC) transporter
FMM49_RS29060	COG1309	transcriptional regulator
FMM49_RS29065	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS29095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS29105	COG0860	N-Acetylmuramoyl-L-alanine amidase
FMM49_RS29115	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS29120	COG0183	Belongs to the thiolase family
FMM49_RS29130	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS29135	COG0509	glycine decarboxylation via glycine cleavage system
FMM49_RS29140	COG2197	response regulator
FMM49_RS29180	COG4585	Histidine kinase
FMM49_RS29185	COG2030	dehydratase
FMM49_RS29195	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS29215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FMM49_RS29230	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FMM49_RS29235	COG0800	Aldolase
FMM49_RS29240	COG3022	response to hydroperoxide
FMM49_RS29245	COG0557	exoribonuclease II activity
FMM49_RS29255	COG0789	Transcriptional regulator
FMM49_RS29265	COG1957	nucleoside hydrolase
FMM49_RS29270	COG3629	intracellular signal transduction
FMM49_RS29270	COG3903	Transcriptional regulator
FMM49_RS29625	COG0776	regulation of translation
FMM49_RS29765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS29770	COG0535	radical SAM domain protein
FMM49_RS29800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FMM49_RS29825	COG3540	Alkaline phosphatase
FMM49_RS29830	COG2814	Major facilitator Superfamily
FMM49_RS29835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FMM49_RS29845	COG1834	amidinotransferase
FMM49_RS29870	COG0672	)-iron permease
FMM49_RS29875	COG2837	iron assimilation
FMM49_RS29885	COG1120	ATPase activity
FMM49_RS29890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS29895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FMM49_RS29915	COG5398	heme oxygenase
FMM49_RS29945	COG1175	transmembrane transport
FMM49_RS29950	COG0395	ABC-type sugar transport system, permease component
FMM49_RS29975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS29980	COG1994	Peptidase M50
FMM49_RS30010	COG1687	branched-chain amino acid
FMM49_RS30015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FMM49_RS30020	COG0477	Major facilitator Superfamily
FMM49_RS30035	COG2814	Major facilitator Superfamily
FMM49_RS30045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FMM49_RS30045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FMM49_RS30050	COG2132	Multicopper oxidase
FMM49_RS30075	COG0174	glutamine synthetase
FMM49_RS30080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FMM49_RS30090	COG1609	Transcriptional regulator
FMM49_RS30095	COG0366	Alpha amylase catalytic
FMM49_RS30100	COG2182	Extracellular solute-binding protein
FMM49_RS30105	COG1175	transmembrane transport
FMM49_RS30110	COG3833	ABC-type maltose transport systems, permease component
FMM49_RS30115	COG0366	Alpha amylase catalytic
FMM49_RS30140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FMM49_RS30195	COG1309	transcriptional regulator
FMM49_RS30220	COG2197	response regulator
FMM49_RS30225	COG4585	Histidine kinase
FMM49_RS30240	COG0745	RESPONSE REGULATOR receiver
FMM49_RS30255	COG3591	Belongs to the peptidase S1B family
FMM49_RS30260	COG0673	inositol 2-dehydrogenase activity
FMM49_RS30275	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS30280	COG0745	RESPONSE REGULATOR receiver
FMM49_RS30285	COG2205	protein histidine kinase activity
FMM49_RS30330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FMM49_RS30335	COG0321	lipoyl(octanoyl) transferase activity
FMM49_RS30350	COG1090	epimerase
FMM49_RS30375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FMM49_RS30385	COG0508	dehydrogenase complex catalyzes the overall conversion of
FMM49_RS30390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FMM49_RS30395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FMM49_RS30405	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS30430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FMM49_RS30445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FMM49_RS30445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FMM49_RS30450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FMM49_RS30470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FMM49_RS30475	COG1132	(ABC) transporter
FMM49_RS30480	COG2226	methyltransferase
FMM49_RS30500	COG4585	Histidine kinase
FMM49_RS30505	COG2197	response regulator
FMM49_RS30510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FMM49_RS30520	COG2161	toxin-antitoxin pair type II binding
FMM49_RS30525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FMM49_RS30545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FMM49_RS30555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FMM49_RS30560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FMM49_RS30570	COG1376	ErfK ybiS ycfS ynhG family protein
FMM49_RS30580	COG1845	cytochrome c oxidase, subunit III
FMM49_RS30585	COG2010	Cytochrome c
FMM49_RS30590	COG0723	plastoquinol--plastocyanin reductase activity
FMM49_RS30595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FMM49_RS30600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FMM49_RS30605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FMM49_RS30615	COG0705	Rhomboid family
FMM49_RS30635	COG3883	PFAM NLP P60 protein
FMM49_RS30635	COG0791	NLP P60 protein
FMM49_RS30650	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS30670	COG0003	Pfam Anion-transporting ATPase
FMM49_RS30680	COG1940	carbohydrate kinase activity
FMM49_RS30715	COG2197	response regulator
FMM49_RS30720	COG0205	6-phosphofructokinase activity
FMM49_RS30725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FMM49_RS30735	COG2267	carboxylic ester hydrolase activity
FMM49_RS30740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FMM49_RS30745	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FMM49_RS30755	COG2193	ferroxidase activity
FMM49_RS30760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FMM49_RS30770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FMM49_RS30775	COG0515	serine threonine protein kinase
FMM49_RS30775	COG2815	serine threonine protein kinase
FMM49_RS30780	COG2022	thiamine diphosphate biosynthetic process
FMM49_RS30790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FMM49_RS30790	COG2022	thiamine diphosphate biosynthetic process
FMM49_RS30805	COG0352	thiamine-phosphate diphosphorylase activity
FMM49_RS30820	COG1233	COG1233 Phytoene dehydrogenase and related
FMM49_RS30830	COG1309	transcriptional regulator
FMM49_RS30850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FMM49_RS30870	COG0714	Associated with various cellular activities
FMM49_RS30880	COG0275	rRNA processing
FMM49_RS30890	COG0768	penicillin binding
FMM49_RS30895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FMM49_RS30905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FMM49_RS30910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FMM49_RS30920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FMM49_RS30925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FMM49_RS30945	COG1799	cell septum assembly
FMM49_RS30955	COG3599	regulation of cell shape
FMM49_RS30960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FMM49_RS30970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FMM49_RS31025	COG0587	DNA-directed DNA polymerase activity
FMM49_RS31035	COG1432	Conserved Protein
FMM49_RS31055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FMM49_RS31070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FMM49_RS31075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FMM49_RS31080	COG0131	Imidazoleglycerol-phosphate dehydratase
FMM49_RS31090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FMM49_RS31095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FMM49_RS31100	COG0251	oxidation-reduction process
FMM49_RS31105	COG0107	imidazoleglycerol-phosphate synthase activity
FMM49_RS31120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FMM49_RS31125	COG1053	succinate dehydrogenase
FMM49_RS31135	COG0583	DNA-binding transcription factor activity
FMM49_RS31140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FMM49_RS31150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FMM49_RS31170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FMM49_RS31195	COG0134	indole-3-glycerol-phosphate synthase activity
FMM49_RS31205	COG0133	tryptophan synthase activity
FMM49_RS31210	COG0159	tryptophan synthase activity
FMM49_RS31220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FMM49_RS31225	COG2301	Belongs to the HpcH HpaI aldolase family
FMM49_RS31230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FMM49_RS31255	COG1609	Transcriptional regulator
FMM49_RS31265	COG0070	glutamate synthase
FMM49_RS31265	COG0069	glutamate synthase activity
FMM49_RS31265	COG0067	glutamate synthase
FMM49_RS31275	COG1846	Transcriptional regulator
FMM49_RS31280	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS31285	COG3467	pyridoxamine 5'-phosphate
FMM49_RS31300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FMM49_RS31305	COG0596	Alpha beta hydrolase
FMM49_RS31340	COG0464	growth
FMM49_RS31360	COG2197	response regulator
FMM49_RS31370	COG0366	Alpha amylase catalytic
FMM49_RS31370	COG1470	cell adhesion involved in biofilm formation
FMM49_RS31400	COG0737	Belongs to the 5'-nucleotidase family
FMM49_RS31455	COG2050	protein possibly involved in aromatic compounds catabolism
FMM49_RS31490	COG1643	Atp-dependent helicase
FMM49_RS31495	COG2226	methyltransferase
FMM49_RS31520	COG0237	dephospho-CoA kinase activity
FMM49_RS31545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FMM49_RS31550	COG4279	zinc finger
FMM49_RS31595	COG0584	glycerophosphoryl diester phosphodiesterase
FMM49_RS31600	COG0556	nucleotide-excision repair
FMM49_RS31645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FMM49_RS31660	COG1063	alcohol dehydrogenase
FMM49_RS31665	COG2814	Major facilitator Superfamily
FMM49_RS31705	COG0322	excinuclease ABC activity
FMM49_RS31710	COG1660	Displays ATPase and GTPase activities
FMM49_RS31720	COG1481	regulation of sporulation
FMM49_RS31725	COG0454	-acetyltransferase
FMM49_RS31725	COG0456	acetyltransferase
FMM49_RS31735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FMM49_RS31740	COG0126	phosphoglycerate kinase activity
FMM49_RS31745	COG0149	triose-phosphate isomerase activity
FMM49_RS31750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FMM49_RS31760	COG0166	Belongs to the GPI family
FMM49_RS31770	COG0363	glucosamine-6-phosphate deaminase activity
FMM49_RS31785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FMM49_RS31790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FMM49_RS31795	COG0109	protoheme IX farnesyltransferase activity
FMM49_RS31810	COG1612	heme a metabolic process
FMM49_RS31835	COG0719	Fe-S assembly protein
FMM49_RS31845	COG0396	ATPase activity
FMM49_RS31850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FMM49_RS31855	COG0822	iron-sulfur transferase activity
FMM49_RS31880	COG2076	Multidrug Resistance protein
FMM49_RS31885	COG3226	Transcriptional regulator
FMM49_RS31895	COG2171	N-acyltransferase activity
FMM49_RS31915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FMM49_RS31945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS31980	COG2261	transglycosylase associated protein
FMM49_RS31985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FMM49_RS31990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FMM49_RS32020	COG4585	Histidine kinase
FMM49_RS32025	COG1414	Transcriptional regulator
FMM49_RS32035	COG0456	acetyltransferase
FMM49_RS32070	COG5285	phytanoyl-CoA dioxygenase
FMM49_RS32075	COG1917	Cupin 2, conserved barrel domain protein
FMM49_RS32080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FMM49_RS32095	COG0385	Bile acid
FMM49_RS32120	COG1797	cobyrinic acid a,c-diamide synthase activity
FMM49_RS32125	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FMM49_RS32135	COG1492	cobalamin metabolic process
FMM49_RS32140	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FMM49_RS32160	COG0235	Class ii aldolase
FMM49_RS32185	COG0488	(ABC) transporter
FMM49_RS32195	COG1024	Enoyl-CoA hydratase
FMM49_RS32205	COG1302	Protein conserved in bacteria
FMM49_RS32235	COG3387	PFAM Glycoside hydrolase 15-related
FMM49_RS32250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FMM49_RS32290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FMM49_RS32295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FMM49_RS32310	COG2261	transglycosylase associated protein
FMM49_RS32315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FMM49_RS32330	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS32335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FMM49_RS32340	COG2186	Transcriptional regulator
FMM49_RS32345	COG2807	transmembrane transport
FMM49_RS32360	COG0560	Phosphoserine phosphatase
FMM49_RS32360	COG3830	Belongs to the UPF0237 family
FMM49_RS32370	COG1131	(ABC) transporter
FMM49_RS32370	COG0842	Transport permease protein
FMM49_RS32370	COG1716	ATPase activity
FMM49_RS32385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FMM49_RS32390	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS32395	COG4585	Histidine kinase
FMM49_RS32400	COG2197	response regulator
FMM49_RS32420	COG1119	ATPase activity
FMM49_RS32445	COG1881	PFAM PEBP family protein
FMM49_RS32455	COG2094	Belongs to the DNA glycosylase MPG family
FMM49_RS32495	COG3486	L-lysine 6-monooxygenase (NADPH) activity
FMM49_RS32510	COG0647	UMP catabolic process
FMM49_RS32525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS32530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS32535	COG1120	ATPase activity
FMM49_RS32555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FMM49_RS32575	COG0497	DNA recombination
FMM49_RS32585	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS32615	COG3387	PFAM Glycoside hydrolase 15-related
FMM49_RS32620	COG0504	CTP synthase activity
FMM49_RS32625	COG0494	nUDIX hydrolase
FMM49_RS32635	COG0686	Belongs to the AlaDH PNT family
FMM49_RS32650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FMM49_RS32655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FMM49_RS32660	COG1187	pseudouridine synthase activity
FMM49_RS32670	COG3541	Predicted nucleotidyltransferase
FMM49_RS32695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FMM49_RS32705	COG1160	GTP binding
FMM49_RS32735	COG0411	ABC transporter
FMM49_RS32770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FMM49_RS32830	COG0671	phosphoesterase, PA-phosphatase related
FMM49_RS32840	COG0477	Major facilitator Superfamily
FMM49_RS32845	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS32850	COG1799	cell septum assembly
FMM49_RS32860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS32865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS32905	COG0326	Molecular chaperone. Has ATPase activity
FMM49_RS32915	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS32925	COG0587	DNA-directed DNA polymerase activity
FMM49_RS32930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FMM49_RS32960	COG0019	diaminopimelate decarboxylase activity
FMM49_RS32990	COG1725	Transcriptional regulator
FMM49_RS33000	COG1834	amidinotransferase
FMM49_RS33020	COG0726	polysaccharide deacetylase
FMM49_RS33025	COG1215	transferase activity, transferring glycosyl groups
FMM49_RS33030	COG0463	Glycosyl transferase, family 2
FMM49_RS33050	COG0515	serine threonine protein kinase
FMM49_RS33070	COG1595	DNA-templated transcription, initiation
FMM49_RS33085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FMM49_RS33095	COG0477	Major facilitator Superfamily
FMM49_RS33095	COG2814	Major facilitator Superfamily
FMM49_RS33100	COG4195	phage-related replication protein
FMM49_RS33105	COG2188	Transcriptional regulator
FMM49_RS33110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FMM49_RS33115	COG2851	Citrate transporter
FMM49_RS33175	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS33215	COG0477	Major facilitator Superfamily
FMM49_RS33220	COG3876	Protein conserved in bacteria
FMM49_RS33230	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS33240	COG0456	acetyltransferase
FMM49_RS33240	COG1846	Transcriptional regulator
FMM49_RS33245	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS33260	COG2149	membrane
FMM49_RS33265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FMM49_RS33290	COG3573	Dehydrogenase
FMM49_RS33325	COG3173	Aminoglycoside phosphotransferase
FMM49_RS33330	COG5002	protein histidine kinase activity
FMM49_RS33335	COG0745	RESPONSE REGULATOR receiver
FMM49_RS33360	COG2124	cytochrome p450
FMM49_RS33365	COG0488	(ABC) transporter
FMM49_RS33460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FMM49_RS33490	COG0667	Aldo Keto reductase
FMM49_RS33495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS33505	COG0598	Magnesium transport protein CorA
FMM49_RS33525	COG0215	cysteine-tRNA ligase activity
FMM49_RS33550	COG4948	Mandelate Racemase Muconate Lactonizing
FMM49_RS33555	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS33565	COG1129	ABC transporter
FMM49_RS33570	COG4211	Belongs to the binding-protein-dependent transport system permease family
FMM49_RS33590	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS33595	COG2186	Transcriptional regulator
FMM49_RS33600	COG0402	S-adenosylhomocysteine deaminase activity
FMM49_RS33605	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FMM49_RS33610	COG0235	Class ii aldolase
FMM49_RS33620	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FMM49_RS33625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FMM49_RS33630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FMM49_RS33635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FMM49_RS33640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FMM49_RS33645	COG1414	Transcriptional regulator
FMM49_RS33650	COG1410	methionine synthase
FMM49_RS33650	COG0646	methionine synthase
FMM49_RS33660	COG4166	transmembrane transport
FMM49_RS33670	COG2197	response regulator
FMM49_RS33680	COG1994	Peptidase M50
FMM49_RS33680	COG0517	IMP dehydrogenase activity
FMM49_RS33700	COG1222	aaa ATPase
FMM49_RS33705	COG4122	O-methyltransferase activity
FMM49_RS33715	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FMM49_RS33720	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FMM49_RS33725	COG1609	Transcriptional regulator
FMM49_RS33735	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FMM49_RS33750	COG2378	regulation of single-species biofilm formation
FMM49_RS33770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FMM49_RS33775	COG0805	protein transport
FMM49_RS33785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FMM49_RS33800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FMM49_RS33805	COG0517	IMP dehydrogenase activity
FMM49_RS33805	COG4175	Glycine betaine
FMM49_RS33810	COG4176	ABC-type proline glycine betaine transport system permease component
FMM49_RS33830	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FMM49_RS33835	COG0531	amino acid
FMM49_RS33840	COG2186	Transcriptional regulator
FMM49_RS33845	COG0174	glutamine synthetase
FMM49_RS33885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FMM49_RS33895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FMM49_RS33900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FMM49_RS33905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FMM49_RS33910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FMM49_RS33915	COG5002	protein histidine kinase activity
FMM49_RS33920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FMM49_RS33925	COG0072	phenylalanine-tRNA ligase activity
FMM49_RS33925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FMM49_RS33955	COG1649	PFAM Uncharacterised BCR, COG1649
FMM49_RS33965	COG0697	spore germination
FMM49_RS33980	COG1486	melibiose metabolic process
FMM49_RS33985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FMM49_RS33990	COG0395	ABC-type sugar transport system, permease component
FMM49_RS33995	COG1175	transmembrane transport
FMM49_RS34000	COG2182	Extracellular solute-binding protein
FMM49_RS34035	COG1595	DNA-templated transcription, initiation
FMM49_RS34040	COG1660	Displays ATPase and GTPase activities
FMM49_RS34065	COG2838	Isocitrate dehydrogenase
FMM49_RS34080	COG4585	Histidine kinase
FMM49_RS34085	COG2197	response regulator
FMM49_RS34115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FMM49_RS34130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FMM49_RS34135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FMM49_RS34140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FMM49_RS34145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FMM49_RS34150	COG1438	arginine binding
FMM49_RS34155	COG1228	amidohydrolase
FMM49_RS34210	COG0137	argininosuccinate synthase activity
FMM49_RS34215	COG0165	Argininosuccinate lyase
FMM49_RS34225	COG0477	Major facilitator Superfamily
FMM49_RS34230	COG0737	Belongs to the 5'-nucleotidase family
FMM49_RS34240	COG0584	glycerophosphoryl diester phosphodiesterase
FMM49_RS34265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FMM49_RS34270	COG2011	ABC-type metal ion transport system permease component
FMM49_RS34275	COG1464	Belongs to the NlpA lipoprotein family
FMM49_RS34290	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FMM49_RS34295	COG1648	precorrin-2 dehydrogenase activity
FMM49_RS34295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FMM49_RS34300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FMM49_RS34360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FMM49_RS34420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FMM49_RS34435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FMM49_RS34465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FMM49_RS34470	COG1560	Kdo2-lipid A biosynthetic process
FMM49_RS34475	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS34490	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FMM49_RS34495	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FMM49_RS34500	COG0217	transcriptional regulatory protein
FMM49_RS34505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FMM49_RS34510	COG0632	four-way junction helicase activity
FMM49_RS34515	COG2255	four-way junction helicase activity
FMM49_RS34525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FMM49_RS34530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FMM49_RS34535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FMM49_RS34540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FMM49_RS34545	COG1196	nuclear chromosome segregation
FMM49_RS34550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FMM49_RS34560	COG0124	histidyl-tRNA synthetase
FMM49_RS34580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FMM49_RS34600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FMM49_RS34605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FMM49_RS34615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FMM49_RS34620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FMM49_RS34625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FMM49_RS34630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FMM49_RS34635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FMM49_RS34645	COG0006	proline dipeptidase activity
FMM49_RS34650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FMM49_RS34655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FMM49_RS34665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FMM49_RS34670	COG0540	Belongs to the ATCase OTCase family
FMM49_RS34675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FMM49_RS34685	COG0505	Belongs to the CarA family
FMM49_RS34690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FMM49_RS34695	COG0167	dihydroorotate dehydrogenase activity
FMM49_RS34700	COG0284	orotidine-5'-phosphate decarboxylase activity
FMM49_RS34725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FMM49_RS34760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FMM49_RS34770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FMM49_RS34775	COG2390	Transcriptional regulator
FMM49_RS34815	COG0531	amino acid
FMM49_RS34835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FMM49_RS34855	COG2233	PERMEase
FMM49_RS34865	COG0738	Major facilitator superfamily
FMM49_RS34870	COG1846	Transcriptional regulator
FMM49_RS34870	COG1940	carbohydrate kinase activity
FMM49_RS34875	COG0702	epimerase
FMM49_RS34890	COG3201	nicotinamide mononucleotide transporter
FMM49_RS34895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FMM49_RS34895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FMM49_RS34900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FMM49_RS34905	COG0140	phosphoribosyl-ATP diphosphatase activity
FMM49_RS34910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FMM49_RS34965	COG0671	phosphoesterase, PA-phosphatase related
FMM49_RS34990	COG0584	glycerophosphoryl diester phosphodiesterase
FMM49_RS35035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FMM49_RS35045	COG1191	sigma factor activity
FMM49_RS35070	COG2318	DinB family
FMM49_RS35075	COG4249	Peptidase C14 caspase catalytic subunit p20
FMM49_RS35075	COG2319	Wd-40 repeat
FMM49_RS35090	COG3973	AAA domain
FMM49_RS35125	COG3345	alpha-galactosidase
FMM49_RS35135	COG1175	transmembrane transport
FMM49_RS35140	COG0395	ABC-type sugar transport system, permease component
FMM49_RS35160	COG0644	oxidoreductase
FMM49_RS35165	COG4585	Histidine kinase
FMM49_RS35170	COG2197	response regulator
FMM49_RS35190	COG1940	carbohydrate kinase activity
FMM49_RS35240	COG1349	DNA-binding transcription factor activity
FMM49_RS35250	COG0464	growth
FMM49_RS35290	COG0463	Glycosyl transferase, family 2
FMM49_RS35295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FMM49_RS35355	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS35400	COG0640	Transcriptional regulator
FMM49_RS35420	COG2111	Na H antiporter
FMM49_RS35425	COG1006	Multisubunit Na H antiporter MnhC subunit
FMM49_RS35430	COG1007	ATP synthesis coupled electron transport
FMM49_RS35440	COG1461	Dihydroxyacetone kinase
FMM49_RS35445	COG2376	Dihydroxyacetone kinase
FMM49_RS35485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FMM49_RS35500	COG0596	Alpha beta hydrolase
FMM49_RS35505	COG0604	alcohol dehydrogenase
FMM49_RS35505	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS35505	COG3321	synthase
FMM49_RS35520	COG1309	transcriptional regulator
FMM49_RS35530	COG1414	Transcriptional regulator
FMM49_RS35535	COG3386	PFAM SMP-30 Gluconolaconase
FMM49_RS35550	COG4214	carbohydrate transport
FMM49_RS35590	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS35590	COG2172	sigma factor antagonist activity
FMM49_RS35590	COG2208	phosphoserine phosphatase activity
FMM49_RS35605	COG2318	DinB family
FMM49_RS35615	COG0367	asparagine synthase
FMM49_RS35640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FMM49_RS35645	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS35650	COG0515	serine threonine protein kinase
FMM49_RS35665	COG2070	2-Nitropropane dioxygenase
FMM49_RS35675	COG2366	antibiotic biosynthetic process
FMM49_RS35680	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS35725	COG1605	Chorismate mutase
FMM49_RS35780	COG4221	oxidoreductase activity
FMM49_RS35815	COG2124	cytochrome p450
FMM49_RS35820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FMM49_RS35865	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS35870	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS35885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FMM49_RS35895	COG1984	allophanate hydrolase subunit 2
FMM49_RS35900	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FMM49_RS35905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FMM49_RS35925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FMM49_RS35970	COG2146	nitrite reductase [NAD(P)H] activity
FMM49_RS36020	COG0442	prolyl-tRNA aminoacylation
FMM49_RS36025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FMM49_RS36030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FMM49_RS36035	COG3447	MASE1 domain protein
FMM49_RS36035	COG5002	protein histidine kinase activity
FMM49_RS36035	COG5001	Diguanylate cyclase
FMM49_RS36040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FMM49_RS36050	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FMM49_RS36065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FMM49_RS36075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FMM49_RS36105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FMM49_RS36125	COG1716	ATPase activity
FMM49_RS36145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FMM49_RS36155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FMM49_RS36155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FMM49_RS36180	COG0384	phenazine biosynthesis protein PhzF
FMM49_RS36190	COG0789	Transcriptional regulator
FMM49_RS36200	COG1695	Transcriptional regulator
FMM49_RS36215	COG0697	spore germination
FMM49_RS36235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FMM49_RS36240	COG0697	spore germination
FMM49_RS36255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FMM49_RS36255	COG0825	malonyl-CoA metabolic process
FMM49_RS36260	COG0318	PFAM AMP-dependent synthetase and ligase
FMM49_RS36280	COG4946	Tricorn protease homolog
FMM49_RS36280	COG0823	Involved in the tonB-independent uptake of proteins
FMM49_RS36280	COG1506	peptidase
FMM49_RS36335	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS36355	COG0154	amidase activity
FMM49_RS36380	COG0667	Aldo Keto reductase
FMM49_RS36385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FMM49_RS36420	COG1132	(ABC) transporter
FMM49_RS36430	COG0640	Transcriptional regulator
FMM49_RS36435	COG1252	NADH dehydrogenase
FMM49_RS36445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FMM49_RS36460	COG0386	Belongs to the glutathione peroxidase family
FMM49_RS36465	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FMM49_RS36470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FMM49_RS36525	COG2267	carboxylic ester hydrolase activity
FMM49_RS36530	COG0531	amino acid
FMM49_RS36580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FMM49_RS36585	COG0019	diaminopimelate decarboxylase activity
FMM49_RS36590	COG0531	amino acid
FMM49_RS36605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FMM49_RS36610	COG2205	protein histidine kinase activity
FMM49_RS36650	COG4733	cellulase activity
FMM49_RS36655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FMM49_RS36715	COG0583	DNA-binding transcription factor activity
FMM49_RS36745	COG3795	YCII-related domain
FMM49_RS36750	COG4941	Belongs to the sigma-70 factor family
FMM49_RS36765	COG1595	DNA-templated transcription, initiation
FMM49_RS36810	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS36815	COG0745	RESPONSE REGULATOR receiver
FMM49_RS36820	COG2205	protein histidine kinase activity
FMM49_RS36840	COG1968	undecaprenyl-diphosphatase activity
FMM49_RS36855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FMM49_RS36900	COG1793	dna ligase
FMM49_RS36900	COG3285	dna ligase
FMM49_RS36910	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS36915	COG0248	Ppx GppA phosphatase
FMM49_RS36935	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS36940	COG0300	oxidoreductase activity
FMM49_RS36970	COG0110	maltose O-acetyltransferase activity
FMM49_RS36980	COG1470	cell adhesion involved in biofilm formation
FMM49_RS36985	COG2124	cytochrome p450
FMM49_RS36990	COG1309	transcriptional regulator
FMM49_RS37025	COG1832	CoA-binding protein
FMM49_RS37030	COG1739	Uncharacterized protein family UPF0029
FMM49_RS37060	COG1335	isochorismatase
FMM49_RS37065	COG1982	Orn Lys Arg decarboxylase major
FMM49_RS37070	COG0243	molybdopterin cofactor binding
FMM49_RS37070	COG3383	formate dehydrogenase (NAD+) activity
FMM49_RS37075	COG0437	4 iron, 4 sulfur cluster binding
FMM49_RS37090	COG1846	Transcriptional regulator
FMM49_RS37100	COG1597	lipid kinase activity
FMM49_RS37110	COG2706	6-phosphogluconolactonase activity
FMM49_RS37120	COG0823	Involved in the tonB-independent uptake of proteins
FMM49_RS37125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FMM49_RS37130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FMM49_RS37175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS37185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS37210	COG0535	radical SAM domain protein
FMM49_RS37225	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FMM49_RS37230	COG2181	nitrate reductase activity
FMM49_RS37240	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FMM49_RS37250	COG1140	nitrate reductase beta subunit
FMM49_RS37290	COG1882	Formate acetyltransferase
FMM49_RS37295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FMM49_RS37310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FMM49_RS37310	COG2146	nitrite reductase [NAD(P)H] activity
FMM49_RS37335	COG0667	Aldo Keto reductase
FMM49_RS37415	COG1113	amino acid transport
FMM49_RS37425	COG1132	(ABC) transporter
FMM49_RS37440	COG0420	3'-5' exonuclease activity
FMM49_RS37445	COG0419	ATPase involved in DNA repair
FMM49_RS37450	COG1522	sequence-specific DNA binding
FMM49_RS37460	COG2226	methyltransferase
FMM49_RS37500	COG1595	DNA-templated transcription, initiation
FMM49_RS37505	COG2188	Transcriptional regulator
FMM49_RS37520	COG1940	carbohydrate kinase activity
FMM49_RS37535	COG3663	DNA glycosylase
FMM49_RS37540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FMM49_RS37555	COG0583	DNA-binding transcription factor activity
FMM49_RS37595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FMM49_RS37600	COG0577	efflux transmembrane transporter activity
FMM49_RS37625	COG2226	methyltransferase
FMM49_RS37630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FMM49_RS37635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FMM49_RS37640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FMM49_RS37685	COG0740	serine-type endopeptidase activity
FMM49_RS37715	COG0831	urea catabolic process
FMM49_RS37720	COG0832	Belongs to the urease beta subunit family
FMM49_RS37725	COG0804	urea catabolic process
FMM49_RS37730	COG0830	nickel cation binding
FMM49_RS37735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FMM49_RS37740	COG0829	nickel cation binding
FMM49_RS37750	COG1309	transcriptional regulator
FMM49_RS37755	COG0154	amidase activity
FMM49_RS37760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS37775	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS37780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS37830	COG0604	alcohol dehydrogenase
FMM49_RS37850	COG0431	NADPH-dependent FMN reductase
FMM49_RS37875	COG1454	alcohol dehydrogenase
FMM49_RS37880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FMM49_RS37885	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS37890	COG3903	Transcriptional regulator
FMM49_RS37890	COG3629	intracellular signal transduction
FMM49_RS37900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FMM49_RS37950	COG0702	epimerase
FMM49_RS37965	COG1473	amidohydrolase
FMM49_RS37970	COG3135	benzoate transporter
FMM49_RS37985	COG2423	ornithine cyclodeaminase activity
FMM49_RS37990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FMM49_RS37995	COG3903	Transcriptional regulator
FMM49_RS37995	COG3629	intracellular signal transduction
FMM49_RS38020	COG1063	alcohol dehydrogenase
FMM49_RS38040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FMM49_RS38055	COG1609	Transcriptional regulator
FMM49_RS38060	COG2222	sugar isomerase
FMM49_RS38070	COG1653	transport
FMM49_RS38075	COG1175	transmembrane transport
FMM49_RS38080	COG0395	ABC-type sugar transport system, permease component
FMM49_RS38085	COG1793	dna ligase
FMM49_RS38090	COG1957	nucleoside hydrolase
FMM49_RS38095	COG0477	Major facilitator Superfamily
FMM49_RS38100	COG0596	Alpha beta hydrolase
FMM49_RS38140	COG0205	6-phosphofructokinase activity
FMM49_RS38145	COG3442	glutamine amidotransferase
FMM49_RS38155	COG0242	peptide deformylase activity
FMM49_RS38165	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS38190	COG0505	Belongs to the CarA family
FMM49_RS38195	COG3960	tartronate-semialdehyde synthase activity
FMM49_RS38200	COG3622	Belongs to the hyi family
FMM49_RS38205	COG2084	Dehydrogenase
FMM49_RS38270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS38270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS38285	COG2378	regulation of single-species biofilm formation
FMM49_RS38315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FMM49_RS38325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FMM49_RS38345	COG1191	sigma factor activity
FMM49_RS38380	COG2124	cytochrome p450
FMM49_RS38405	COG1653	transport
FMM49_RS38420	COG0395	ABC-type sugar transport system, permease component
FMM49_RS38455	COG0395	ABC-type sugar transport system, permease component
FMM49_RS38490	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS38510	COG3284	Transcriptional regulator
FMM49_RS38525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS38560	COG2197	response regulator
FMM49_RS38590	COG1657	PFAM Prenyltransferase squalene oxidase
FMM49_RS38610	COG0142	geranyltranstransferase activity
FMM49_RS38615	COG1482	cell wall glycoprotein biosynthetic process
FMM49_RS38670	COG1012	belongs to the aldehyde dehydrogenase family
FMM49_RS38675	COG2197	response regulator
FMM49_RS38680	COG4977	sequence-specific DNA binding
FMM49_RS38685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FMM49_RS38710	COG1063	alcohol dehydrogenase
FMM49_RS38715	COG2207	Transcriptional regulator
FMM49_RS38725	COG0328	RNA-DNA hybrid ribonuclease activity
FMM49_RS38730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FMM49_RS38755	COG1116	anion transmembrane transporter activity
FMM49_RS38790	COG1316	TRANSCRIPTIONal
FMM49_RS38825	COG0745	RESPONSE REGULATOR receiver
FMM49_RS38835	COG0829	nickel cation binding
FMM49_RS38840	COG4585	Histidine kinase
FMM49_RS38845	COG2197	response regulator
FMM49_RS38855	COG0438	transferase activity, transferring glycosyl groups
FMM49_RS38950	COG2124	cytochrome p450
FMM49_RS38965	COG0596	Alpha beta hydrolase
FMM49_RS39030	COG0671	phosphoesterase, PA-phosphatase related
FMM49_RS39060	COG4221	oxidoreductase activity
FMM49_RS39080	COG0110	maltose O-acetyltransferase activity
FMM49_RS39105	COG0367	asparagine synthase
FMM49_RS39120	COG2124	cytochrome p450
FMM49_RS39150	COG0583	DNA-binding transcription factor activity
FMM49_RS39170	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS39170	COG0604	alcohol dehydrogenase
FMM49_RS39170	COG3321	synthase
FMM49_RS39185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FMM49_RS39205	COG2732	(Barnase) inhibitor
FMM49_RS39275	COG0494	nUDIX hydrolase
FMM49_RS39320	COG0596	Alpha beta hydrolase
FMM49_RS39325	COG4221	oxidoreductase activity
FMM49_RS39350	COG3848	Pyruvate phosphate dikinase
FMM49_RS39350	COG0574	Belongs to the PEP-utilizing enzyme family
FMM49_RS39385	COG1228	amidohydrolase
FMM49_RS39390	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FMM49_RS39415	COG4106	trans-aconitate 2-methyltransferase activity
FMM49_RS39455	COG2197	response regulator
FMM49_RS39495	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
FMM49_RS39510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FMM49_RS39520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FMM49_RS39550	COG2208	phosphoserine phosphatase activity
FMM49_RS39550	COG2770	Histidine kinase
FMM49_RS39560	COG2172	sigma factor antagonist activity
FMM49_RS39565	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS39570	COG1366	Belongs to the anti-sigma-factor antagonist family
FMM49_RS39575	COG1191	sigma factor activity
FMM49_RS39600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FMM49_RS39615	COG2175	clavaminate synthase activity
FMM49_RS39630	COG3903	Transcriptional regulator
FMM49_RS39630	COG3629	intracellular signal transduction
FMM49_RS39645	COG0583	DNA-binding transcription factor activity
FMM49_RS39655	COG0189	ligase activity
FMM49_RS39715	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS39720	COG2259	Doxx family
FMM49_RS39785	COG0154	amidase activity
FMM49_RS39790	COG0300	oxidoreductase activity
FMM49_RS39800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FMM49_RS39840	COG0477	Major facilitator Superfamily
FMM49_RS39850	COG2271	Major facilitator Superfamily
FMM49_RS39860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FMM49_RS39865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS39870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FMM49_RS39885	COG0346	lactoylglutathione lyase activity
FMM49_RS39910	COG0366	Alpha amylase catalytic
FMM49_RS39925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FMM49_RS39935	COG0745	RESPONSE REGULATOR receiver
FMM49_RS39940	COG2205	protein histidine kinase activity
FMM49_RS39945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS39960	COG1131	(ABC) transporter
FMM49_RS39980	COG1191	sigma factor activity
FMM49_RS39990	COG0596	Alpha beta hydrolase
FMM49_RS39995	COG1309	transcriptional regulator
FMM49_RS40000	COG0640	Transcriptional regulator
FMM49_RS40005	COG0673	inositol 2-dehydrogenase activity
FMM49_RS40025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FMM49_RS40040	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS40050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FMM49_RS40055	COG2124	cytochrome p450
FMM49_RS40060	COG2124	cytochrome p450
FMM49_RS40120	COG0657	acetylesterase activity
FMM49_RS40125	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS40150	COG1960	acyl-CoA dehydrogenase activity
FMM49_RS40160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FMM49_RS40175	COG0585	pseudouridine synthase activity
FMM49_RS40215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS40220	COG3251	PFAM MbtH domain protein
FMM49_RS40240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FMM49_RS40245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS40255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS40265	COG0789	Transcriptional regulator
FMM49_RS40285	COG0745	RESPONSE REGULATOR receiver
FMM49_RS40300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FMM49_RS40310	COG1181	Belongs to the D-alanine--D-alanine ligase family
FMM49_RS40315	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FMM49_RS40350	COG2208	phosphoserine phosphatase activity
FMM49_RS40350	COG2770	Histidine kinase
FMM49_RS40355	COG0596	Alpha beta hydrolase
FMM49_RS40360	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS40375	COG1301	dicarboxylic acid transport
FMM49_RS40380	COG0473	3-isopropylmalate dehydrogenase activity
FMM49_RS40385	COG0583	DNA-binding transcription factor activity
FMM49_RS40430	COG0477	Major facilitator Superfamily
FMM49_RS40475	COG2205	protein histidine kinase activity
FMM49_RS40510	COG0583	DNA-binding transcription factor activity
FMM49_RS40515	COG0384	phenazine biosynthesis protein PhzF
FMM49_RS40585	COG0137	argininosuccinate synthase activity
FMM49_RS40615	COG1028	Short-chain dehydrogenase reductase Sdr
FMM49_RS40635	COG0456	acetyltransferase
FMM49_RS40635	COG1214	PFAM Peptidase M22, glycoprotease
FMM49_RS40655	COG0596	Alpha beta hydrolase
FMM49_RS40665	COG2814	Major facilitator Superfamily
FMM49_RS40675	COG0697	spore germination
FMM49_RS40750	COG1254	Belongs to the acylphosphatase family
FMM49_RS40765	COG0604	alcohol dehydrogenase
FMM49_RS40770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FMM49_RS40810	COG1309	transcriptional regulator
FMM49_RS40820	COG0251	oxidation-reduction process
FMM49_RS40830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FMM49_RS40830	COG2022	thiamine diphosphate biosynthetic process
FMM49_RS40885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FMM49_RS40895	COG0300	oxidoreductase activity
FMM49_RS40900	COG0300	oxidoreductase activity
FMM49_RS40910	COG2409	Drug exporters of the RND superfamily
FMM49_RS40915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FMM49_RS40920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FMM49_RS40925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FMM49_RS40990	COG1278	Cold shock
FMM49_RS41025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FMM49_RS41105	COG1185	polyribonucleotide nucleotidyltransferase activity
FMM49_RS41225	COG1302	Protein conserved in bacteria
FMM49_RS41325	COG0237	dephospho-CoA kinase activity
FMM49_RS41325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FMM49_RS41415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FMM49_RS41480	COG0521	Mo-molybdopterin cofactor biosynthetic process