locus-tag	class	description
A4G23_RS00105	COG0419	ATPase involved in DNA repair
A4G23_RS00110	COG0420	3'-5' exonuclease activity
A4G23_RS00125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G23_RS00155	COG2267	carboxylic ester hydrolase activity
A4G23_RS00210	COG1937	Protein conserved in bacteria
A4G23_RS00215	COG4989	oxidoreductase activity
A4G23_RS00220	COG1742	UPF0060 membrane protein
A4G23_RS00275	COG1191	sigma factor activity
A4G23_RS00285	COG1278	Cold shock
A4G23_RS00310	COG0477	Major facilitator Superfamily
A4G23_RS00330	COG3437	response regulator, receiver
A4G23_RS00330	COG2205	protein histidine kinase activity
A4G23_RS00330	COG4999	Histidine kinase
A4G23_RS00330	COG3850	Histidine kinase
A4G23_RS00345	COG2271	Major facilitator Superfamily
A4G23_RS00380	COG3655	Transcriptional regulator
A4G23_RS00390	COG3548	integral membrane protein
A4G23_RS00395	COG0640	Transcriptional regulator
A4G23_RS00400	COG1902	pentaerythritol trinitrate reductase activity
A4G23_RS00410	COG2223	nitrite transmembrane transporter activity
A4G23_RS00415	COG2207	Transcriptional regulator
A4G23_RS00435	COG2308	Evidence 4 Homologs of previously reported genes of
A4G23_RS00435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4G23_RS00445	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A4G23_RS00450	COG2326	polyphosphate kinase activity
A4G23_RS00470	COG2226	methyltransferase
A4G23_RS00555	COG0463	Glycosyl transferase, family 2
A4G23_RS00610	COG2366	antibiotic biosynthetic process
A4G23_RS00615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4G23_RS00630	COG0515	serine threonine protein kinase
A4G23_RS00630	COG2815	serine threonine protein kinase
A4G23_RS00640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G23_RS00640	COG0723	plastoquinol--plastocyanin reductase activity
A4G23_RS00670	COG4209	transmembrane transport
A4G23_RS00675	COG0395	ABC-type sugar transport system, permease component
A4G23_RS00715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4G23_RS00715	COG1796	DNA polymerase
A4G23_RS00735	COG1295	ribonuclease BN
A4G23_RS00740	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS00745	COG1131	(ABC) transporter
A4G23_RS00745	COG1716	ATPase activity
A4G23_RS00745	COG0842	Transport permease protein
A4G23_RS00770	COG0778	Nitroreductase
A4G23_RS00790	COG1404	Belongs to the peptidase S8 family
A4G23_RS00805	COG3766	membrane
A4G23_RS00810	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A4G23_RS00825	COG0006	proline dipeptidase activity
A4G23_RS00830	COG0006	proline dipeptidase activity
A4G23_RS00840	COG3291	Pkd domain containing protein
A4G23_RS00845	COG3938	Belongs to the proline racemase family
A4G23_RS00850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G23_RS00855	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4G23_RS00860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4G23_RS00860	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4G23_RS00865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G23_RS00875	COG2376	Dihydroxyacetone kinase
A4G23_RS00880	COG1461	Dihydroxyacetone kinase
A4G23_RS00890	COG0310	cobalt ion transport
A4G23_RS00895	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
A4G23_RS00905	COG1122	ATPase activity
A4G23_RS00910	COG0477	Major facilitator Superfamily
A4G23_RS00925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4G23_RS00930	COG1902	pentaerythritol trinitrate reductase activity
A4G23_RS00930	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4G23_RS01005	COG0753	catalase activity
A4G23_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS01030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4G23_RS01050	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4G23_RS01055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G23_RS01060	COG2192	nodulation
A4G23_RS01070	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS01075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4G23_RS01080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4G23_RS01080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4G23_RS01090	COG4221	oxidoreductase activity
A4G23_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS01185	COG4106	trans-aconitate 2-methyltransferase activity
A4G23_RS01190	COG3290	protein histidine kinase activity
A4G23_RS01200	COG0596	Alpha beta hydrolase
A4G23_RS01235	COG2239	Acts as a magnesium transporter
A4G23_RS01250	COG0574	Belongs to the PEP-utilizing enzyme family
A4G23_RS01250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G23_RS01265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G23_RS01265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G23_RS01270	COG2124	cytochrome p450
A4G23_RS01275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G23_RS01315	COG2124	cytochrome p450
A4G23_RS01335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4G23_RS01335	COG1796	DNA polymerase
A4G23_RS01340	COG3962	Belongs to the TPP enzyme family
A4G23_RS01345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G23_RS01455	COG0640	Transcriptional regulator
A4G23_RS01480	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4G23_RS01500	COG1017	nitric oxide dioxygenase activity
A4G23_RS01500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4G23_RS01505	COG1959	2 iron, 2 sulfur cluster binding
A4G23_RS01515	COG4106	trans-aconitate 2-methyltransferase activity
A4G23_RS01550	COG0328	RNA-DNA hybrid ribonuclease activity
A4G23_RS01560	COG1733	regulation of RNA biosynthetic process
A4G23_RS01600	COG1309	transcriptional regulator
A4G23_RS01610	COG0789	Transcriptional regulator
A4G23_RS01640	COG1482	cell wall glycoprotein biosynthetic process
A4G23_RS01650	COG1609	Transcriptional regulator
A4G23_RS01655	COG3250	beta-galactosidase activity
A4G23_RS01665	COG1175	transmembrane transport
A4G23_RS01670	COG0395	ABC-type sugar transport system, permease component
A4G23_RS01675	COG1051	belongs to the nudix hydrolase family
A4G23_RS01685	COG2226	methyltransferase
A4G23_RS01710	COG1121	(ABC) transporter
A4G23_RS01750	COG1215	transferase activity, transferring glycosyl groups
A4G23_RS01770	COG0464	growth
A4G23_RS01780	COG1349	DNA-binding transcription factor activity
A4G23_RS01825	COG1940	carbohydrate kinase activity
A4G23_RS01855	COG0445	tRNA wobble uridine modification
A4G23_RS01870	COG1660	Displays ATPase and GTPase activities
A4G23_RS01875	COG1470	cell adhesion involved in biofilm formation
A4G23_RS01910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G23_RS01920	COG2909	trisaccharide binding
A4G23_RS01920	COG2909	trisaccharide binding
A4G23_RS01935	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4G23_RS01955	COG0204	Acyl-transferase
A4G23_RS01975	COG0542	response to heat
A4G23_RS01995	COG0671	phosphoesterase, PA-phosphatase related
A4G23_RS02000	COG1309	transcriptional regulator
A4G23_RS02010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4G23_RS02025	COG2706	6-phosphogluconolactonase activity
A4G23_RS02035	COG4948	Mandelate Racemase Muconate Lactonizing
A4G23_RS02050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G23_RS02060	COG0395	ABC-type sugar transport system, permease component
A4G23_RS02065	COG1175	transmembrane transport
A4G23_RS02085	COG0546	phosphoglycolate phosphatase activity
A4G23_RS02090	COG3842	ATPase activity
A4G23_RS02095	COG1178	ABC-type Fe3 transport system permease component
A4G23_RS02105	COG0318	PFAM AMP-dependent synthetase and ligase
A4G23_RS02115	COG2226	methyltransferase
A4G23_RS02125	COG4981	capsule polysaccharide biosynthetic process
A4G23_RS02135	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS02155	COG3693	PFAM glycoside hydrolase, family 10
A4G23_RS02160	COG0395	ABC-type sugar transport system, permease component
A4G23_RS02165	COG1175	transmembrane transport
A4G23_RS02175	COG1609	Transcriptional regulator
A4G23_RS02180	COG1472	Belongs to the glycosyl hydrolase 3 family
A4G23_RS02185	COG3507	Belongs to the glycosyl hydrolase 43 family
A4G23_RS02200	COG2160	L-arabinose isomerase activity
A4G23_RS02210	COG1609	Transcriptional regulator
A4G23_RS02220	COG1129	ABC transporter
A4G23_RS02225	COG4214	carbohydrate transport
A4G23_RS02235	COG0326	Molecular chaperone. Has ATPase activity
A4G23_RS02250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4G23_RS02260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS02280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4G23_RS02285	COG0297	glycogen (starch) synthase activity
A4G23_RS02310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4G23_RS02340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4G23_RS02350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4G23_RS02365	COG0432	Pfam Uncharacterised protein family UPF0047
A4G23_RS02375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4G23_RS02380	COG1132	(ABC) transporter
A4G23_RS02385	COG1846	Transcriptional regulator
A4G23_RS02400	COG1132	(ABC) transporter
A4G23_RS02405	COG1132	(ABC) transporter
A4G23_RS02425	COG0386	Belongs to the glutathione peroxidase family
A4G23_RS02435	COG1136	(ABC) transporter
A4G23_RS02435	COG0577	efflux transmembrane transporter activity
A4G23_RS02445	COG1653	transport
A4G23_RS02450	COG0366	Alpha amylase catalytic
A4G23_RS02455	COG1653	transport
A4G23_RS02460	COG1175	transmembrane transport
A4G23_RS02465	COG0395	ABC-type sugar transport system, permease component
A4G23_RS02470	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS02480	COG0242	peptide deformylase activity
A4G23_RS02490	COG3442	glutamine amidotransferase
A4G23_RS02495	COG0205	6-phosphofructokinase activity
A4G23_RS02540	COG0204	Acyl-transferase
A4G23_RS02550	COG0740	serine-type endopeptidase activity
A4G23_RS02575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4G23_RS02580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4G23_RS02585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4G23_RS02595	COG2226	methyltransferase
A4G23_RS02740	COG2124	cytochrome p450
A4G23_RS02750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4G23_RS02755	COG3663	DNA glycosylase
A4G23_RS02765	COG1940	carbohydrate kinase activity
A4G23_RS02815	COG1522	sequence-specific DNA binding
A4G23_RS02820	COG0419	ATPase involved in DNA repair
A4G23_RS02825	COG0420	3'-5' exonuclease activity
A4G23_RS02830	COG1739	Uncharacterized protein family UPF0029
A4G23_RS02840	COG1832	CoA-binding protein
A4G23_RS02845	COG4214	carbohydrate transport
A4G23_RS02855	COG4213	ABC transporter substrate-binding protein
A4G23_RS02865	COG0110	maltose O-acetyltransferase activity
A4G23_RS02900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4G23_RS02910	COG1968	undecaprenyl-diphosphatase activity
A4G23_RS02925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4G23_RS02930	COG0673	inositol 2-dehydrogenase activity
A4G23_RS02945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4G23_RS02955	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS03040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4G23_RS03040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4G23_RS03050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4G23_RS03070	COG1716	ATPase activity
A4G23_RS03090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4G23_RS03120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G23_RS03130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4G23_RS03145	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A4G23_RS03200	COG2814	Major facilitator Superfamily
A4G23_RS03205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4G23_RS03210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4G23_RS03215	COG1984	allophanate hydrolase subunit 2
A4G23_RS03250	COG2270	Major facilitator Superfamily
A4G23_RS03265	COG1216	Glycosyl transferase, family 2
A4G23_RS03285	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS03315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G23_RS03350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4G23_RS03355	COG0140	phosphoribosyl-ATP diphosphatase activity
A4G23_RS03360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4G23_RS03365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G23_RS03365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G23_RS03370	COG3201	nicotinamide mononucleotide transporter
A4G23_RS03390	COG1595	DNA-templated transcription, initiation
A4G23_RS03395	COG1090	epimerase
A4G23_RS03400	COG1846	Transcriptional regulator
A4G23_RS03400	COG1940	carbohydrate kinase activity
A4G23_RS03410	COG2233	PERMEase
A4G23_RS03420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4G23_RS03430	COG0531	amino acid
A4G23_RS03440	COG1366	Belongs to the anti-sigma-factor antagonist family
A4G23_RS03445	COG1366	Belongs to the anti-sigma-factor antagonist family
A4G23_RS03450	COG2172	sigma factor antagonist activity
A4G23_RS03460	COG2208	phosphoserine phosphatase activity
A4G23_RS03460	COG2770	Histidine kinase
A4G23_RS03470	COG1191	sigma factor activity
A4G23_RS03480	COG2390	Transcriptional regulator
A4G23_RS03485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4G23_RS03495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4G23_RS03510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4G23_RS03535	COG0284	orotidine-5'-phosphate decarboxylase activity
A4G23_RS03540	COG0167	dihydroorotate dehydrogenase activity
A4G23_RS03545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4G23_RS03550	COG0505	Belongs to the CarA family
A4G23_RS03560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4G23_RS03565	COG0540	Belongs to the ATCase OTCase family
A4G23_RS03570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4G23_RS03580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4G23_RS03585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4G23_RS03590	COG0006	proline dipeptidase activity
A4G23_RS03600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4G23_RS03605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4G23_RS03610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4G23_RS03615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4G23_RS03620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4G23_RS03630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4G23_RS03635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4G23_RS03650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4G23_RS03670	COG0124	histidyl-tRNA synthetase
A4G23_RS03685	COG1196	nuclear chromosome segregation
A4G23_RS03690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G23_RS03700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4G23_RS03705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G23_RS03710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G23_RS03715	COG1862	Preprotein translocase
A4G23_RS03720	COG2255	four-way junction helicase activity
A4G23_RS03725	COG0632	four-way junction helicase activity
A4G23_RS03730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4G23_RS03735	COG0217	transcriptional regulatory protein
A4G23_RS03740	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A4G23_RS03745	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A4G23_RS03760	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS03765	COG1560	Kdo2-lipid A biosynthetic process
A4G23_RS03770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4G23_RS03790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4G23_RS03805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G23_RS03860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4G23_RS03905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4G23_RS03905	COG1648	precorrin-2 dehydrogenase activity
A4G23_RS03910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A4G23_RS03925	COG1464	Belongs to the NlpA lipoprotein family
A4G23_RS03930	COG2011	ABC-type metal ion transport system permease component
A4G23_RS03935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4G23_RS03955	COG0584	glycerophosphoryl diester phosphodiesterase
A4G23_RS03960	COG0318	PFAM AMP-dependent synthetase and ligase
A4G23_RS03960	COG0204	Acyl-transferase
A4G23_RS03965	COG0477	Major facilitator Superfamily
A4G23_RS03975	COG0165	Argininosuccinate lyase
A4G23_RS03980	COG0137	argininosuccinate synthase activity
A4G23_RS03990	COG1438	arginine binding
A4G23_RS03995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G23_RS04000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4G23_RS04005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4G23_RS04010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4G23_RS04020	COG3851	Histidine kinase
A4G23_RS04025	COG2197	response regulator
A4G23_RS04040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A4G23_RS04045	COG2197	response regulator
A4G23_RS04045	COG3903	Transcriptional regulator
A4G23_RS04060	COG2813	Specifically methylates the guanine in position
A4G23_RS04080	COG1649	PFAM Uncharacterised BCR, COG1649
A4G23_RS04095	COG0072	phenylalanine-tRNA ligase activity
A4G23_RS04095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G23_RS04100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4G23_RS04105	COG5002	protein histidine kinase activity
A4G23_RS04110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G23_RS04115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4G23_RS04120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4G23_RS04125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4G23_RS04165	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS04170	COG0174	glutamine synthetase
A4G23_RS04185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4G23_RS04210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G23_RS04235	COG0805	protein transport
A4G23_RS04240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G23_RS04260	COG2378	regulation of single-species biofilm formation
A4G23_RS04270	COG0545	Peptidyl-prolyl cis-trans isomerase
A4G23_RS04275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4G23_RS04285	COG1609	Transcriptional regulator
A4G23_RS04290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4G23_RS04295	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4G23_RS04310	COG4122	O-methyltransferase activity
A4G23_RS04315	COG1222	aaa ATPase
A4G23_RS04335	COG1994	Peptidase M50
A4G23_RS04335	COG0517	IMP dehydrogenase activity
A4G23_RS04345	COG2197	response regulator
A4G23_RS04350	COG4166	transmembrane transport
A4G23_RS04365	COG1410	methionine synthase
A4G23_RS04365	COG0646	methionine synthase
A4G23_RS04370	COG1414	Transcriptional regulator
A4G23_RS04375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4G23_RS04380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4G23_RS04385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4G23_RS04395	COG0215	cysteine-tRNA ligase activity
A4G23_RS04415	COG0598	Magnesium transport protein CorA
A4G23_RS04425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G23_RS04430	COG0667	Aldo Keto reductase
A4G23_RS04460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G23_RS04480	COG1070	Carbohydrate kinase
A4G23_RS04485	COG1501	Belongs to the glycosyl hydrolase 31 family
A4G23_RS04495	COG2186	Transcriptional regulator
A4G23_RS04500	COG3265	gluconokinase activity
A4G23_RS04515	COG3573	Dehydrogenase
A4G23_RS04520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4G23_RS04525	COG2149	membrane
A4G23_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS04570	COG3876	Protein conserved in bacteria
A4G23_RS04630	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS04670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A4G23_RS04675	COG2188	Transcriptional regulator
A4G23_RS04700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4G23_RS04710	COG2755	lipolytic protein G-D-S-L family
A4G23_RS04725	COG0456	acetyltransferase
A4G23_RS04735	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4G23_RS04745	COG0587	DNA-directed DNA polymerase activity
A4G23_RS04760	COG1799	cell septum assembly
A4G23_RS04765	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS04770	COG0477	Major facilitator Superfamily
A4G23_RS04775	COG0671	phosphoesterase, PA-phosphatase related
A4G23_RS04785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4G23_RS04795	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS04815	COG0411	ABC transporter
A4G23_RS04840	COG1160	GTP binding
A4G23_RS04850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4G23_RS04865	COG3541	Predicted nucleotidyltransferase
A4G23_RS04875	COG0494	nUDIX hydrolase
A4G23_RS04880	COG1187	pseudouridine synthase activity
A4G23_RS04885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4G23_RS04890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4G23_RS04905	COG0686	Belongs to the AlaDH PNT family
A4G23_RS04915	COG0494	nUDIX hydrolase
A4G23_RS04920	COG0504	CTP synthase activity
A4G23_RS04925	COG3387	PFAM Glycoside hydrolase 15-related
A4G23_RS04930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4G23_RS04935	COG0297	glycogen (starch) synthase activity
A4G23_RS04945	COG0497	DNA recombination
A4G23_RS04950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4G23_RS04965	COG1120	ATPase activity
A4G23_RS04970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G23_RS04975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G23_RS04980	COG0647	UMP catabolic process
A4G23_RS05015	COG2094	Belongs to the DNA glycosylase MPG family
A4G23_RS05020	COG2094	Belongs to the DNA glycosylase MPG family
A4G23_RS05030	COG1881	PFAM PEBP family protein
A4G23_RS05055	COG1119	ATPase activity
A4G23_RS05065	COG2197	response regulator
A4G23_RS05070	COG4585	Histidine kinase
A4G23_RS05080	COG1131	(ABC) transporter
A4G23_RS05080	COG1716	ATPase activity
A4G23_RS05080	COG0842	Transport permease protein
A4G23_RS05085	COG0560	Phosphoserine phosphatase
A4G23_RS05085	COG3830	Belongs to the UPF0237 family
A4G23_RS05110	COG2186	Transcriptional regulator
A4G23_RS05120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4G23_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS05160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4G23_RS05180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4G23_RS05185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G23_RS05200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4G23_RS05235	COG3387	PFAM Glycoside hydrolase 15-related
A4G23_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS05245	COG1024	Enoyl-CoA hydratase
A4G23_RS05255	COG0488	(ABC) transporter
A4G23_RS05275	COG0235	Class ii aldolase
A4G23_RS05290	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A4G23_RS05295	COG1492	cobalamin metabolic process
A4G23_RS05305	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A4G23_RS05310	COG1797	cobyrinic acid a,c-diamide synthase activity
A4G23_RS05345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4G23_RS05350	COG0583	DNA-binding transcription factor activity
A4G23_RS05360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4G23_RS05375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4G23_RS05390	COG1414	Transcriptional regulator
A4G23_RS05405	COG4585	Histidine kinase
A4G23_RS05410	COG2197	response regulator
A4G23_RS05420	COG3866	Pectate lyase
A4G23_RS05425	COG2755	lipolytic protein G-D-S-L family
A4G23_RS05450	COG0395	ABC-type sugar transport system, permease component
A4G23_RS05455	COG1175	transmembrane transport
A4G23_RS05470	COG1802	Transcriptional regulator
A4G23_RS05480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G23_RS05530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G23_RS05540	COG2171	N-acyltransferase activity
A4G23_RS05555	COG0822	iron-sulfur transferase activity
A4G23_RS05560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4G23_RS05565	COG0396	ATPase activity
A4G23_RS05575	COG0719	Fe-S assembly protein
A4G23_RS05590	COG1131	(ABC) transporter
A4G23_RS05600	COG1612	heme a metabolic process
A4G23_RS05610	COG0109	protoheme IX farnesyltransferase activity
A4G23_RS05620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4G23_RS05635	COG0363	glucosamine-6-phosphate deaminase activity
A4G23_RS05655	COG0166	Belongs to the GPI family
A4G23_RS05665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G23_RS05670	COG0149	triose-phosphate isomerase activity
A4G23_RS05675	COG0126	phosphoglycerate kinase activity
A4G23_RS05680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4G23_RS05685	COG1481	regulation of sporulation
A4G23_RS05690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4G23_RS05695	COG1660	Displays ATPase and GTPase activities
A4G23_RS05700	COG0322	excinuclease ABC activity
A4G23_RS05710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4G23_RS05725	COG0477	Major facilitator Superfamily
A4G23_RS05745	COG0556	nucleotide-excision repair
A4G23_RS05765	COG2313	pseudouridylate synthase activity
A4G23_RS05770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G23_RS05790	COG0436	Aminotransferase
A4G23_RS05810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4G23_RS05825	COG0237	dephospho-CoA kinase activity
A4G23_RS05840	COG2226	methyltransferase
A4G23_RS05845	COG1643	Atp-dependent helicase
A4G23_RS05870	COG2050	protein possibly involved in aromatic compounds catabolism
A4G23_RS05925	COG1605	Chorismate mutase
A4G23_RS05925	COG0287	Prephenate dehydrogenase
A4G23_RS05950	COG2304	oxidoreductase activity
A4G23_RS05960	COG0067	glutamate synthase
A4G23_RS05960	COG0069	glutamate synthase activity
A4G23_RS05960	COG0070	glutamate synthase
A4G23_RS05970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G23_RS05975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4G23_RS05985	COG0159	tryptophan synthase activity
A4G23_RS05990	COG0133	tryptophan synthase activity
A4G23_RS06000	COG0134	indole-3-glycerol-phosphate synthase activity
A4G23_RS06020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4G23_RS06025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4G23_RS06040	COG0107	imidazoleglycerol-phosphate synthase activity
A4G23_RS06045	COG0251	oxidation-reduction process
A4G23_RS06050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4G23_RS06055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4G23_RS06060	COG0131	Imidazoleglycerol-phosphate dehydratase
A4G23_RS06065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4G23_RS06070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4G23_RS06110	COG1432	Conserved Protein
A4G23_RS06115	COG0587	DNA-directed DNA polymerase activity
A4G23_RS06190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4G23_RS06200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4G23_RS06205	COG3599	regulation of cell shape
A4G23_RS06215	COG1799	cell septum assembly
A4G23_RS06220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4G23_RS06225	COG1496	oxidoreductase activity
A4G23_RS06235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4G23_RS06240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4G23_RS06250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4G23_RS06255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4G23_RS06265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4G23_RS06270	COG0768	penicillin binding
A4G23_RS06280	COG0275	rRNA processing
A4G23_RS06290	COG0714	Associated with various cellular activities
A4G23_RS06310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4G23_RS06320	COG1511	domain protein
A4G23_RS06325	COG1309	transcriptional regulator
A4G23_RS06330	COG1233	COG1233 Phytoene dehydrogenase and related
A4G23_RS06345	COG0352	thiamine-phosphate diphosphorylase activity
A4G23_RS06360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G23_RS06360	COG2022	thiamine diphosphate biosynthetic process
A4G23_RS06370	COG2022	thiamine diphosphate biosynthetic process
A4G23_RS06375	COG0515	serine threonine protein kinase
A4G23_RS06375	COG2815	serine threonine protein kinase
A4G23_RS06380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4G23_RS06385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4G23_RS06390	COG2193	ferroxidase activity
A4G23_RS06395	COG0243	molybdopterin cofactor binding
A4G23_RS06400	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A4G23_RS06415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4G23_RS06425	COG4585	Histidine kinase
A4G23_RS06450	COG1940	carbohydrate kinase activity
A4G23_RS06460	COG0003	Pfam Anion-transporting ATPase
A4G23_RS06480	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS06525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4G23_RS06530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4G23_RS06535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4G23_RS06540	COG0723	plastoquinol--plastocyanin reductase activity
A4G23_RS06545	COG2010	Cytochrome c
A4G23_RS06550	COG1845	cytochrome c oxidase, subunit III
A4G23_RS06560	COG1376	ErfK ybiS ycfS ynhG family protein
A4G23_RS06570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4G23_RS06575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4G23_RS06585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G23_RS06605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4G23_RS06610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4G23_RS06615	COG2197	response regulator
A4G23_RS06620	COG4585	Histidine kinase
A4G23_RS06645	COG1132	(ABC) transporter
A4G23_RS06650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G23_RS06665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A4G23_RS06680	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A4G23_RS06685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4G23_RS06690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G23_RS06695	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G23_RS06705	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4G23_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS06750	COG0321	lipoyl(octanoyl) transferase activity
A4G23_RS06755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4G23_RS06785	COG0596	Alpha beta hydrolase
A4G23_RS06790	COG1846	Transcriptional regulator
A4G23_RS06850	COG0366	Alpha amylase catalytic
A4G23_RS06855	COG3833	ABC-type maltose transport systems, permease component
A4G23_RS06860	COG1175	transmembrane transport
A4G23_RS06865	COG1653	transport
A4G23_RS06870	COG0366	Alpha amylase catalytic
A4G23_RS06875	COG1609	Transcriptional regulator
A4G23_RS06885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4G23_RS06890	COG0174	glutamine synthetase
A4G23_RS06920	COG2267	carboxylic ester hydrolase activity
A4G23_RS06935	COG2132	Multicopper oxidase
A4G23_RS06940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4G23_RS06940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4G23_RS06950	COG0477	Major facilitator Superfamily
A4G23_RS06955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4G23_RS06960	COG1994	Peptidase M50
A4G23_RS07025	COG2814	Major facilitator Superfamily
A4G23_RS07035	COG3540	Alkaline phosphatase
A4G23_RS07040	COG0384	phenazine biosynthesis protein PhzF
A4G23_RS07075	COG1476	TRANSCRIPTIONal
A4G23_RS07105	COG3022	response to hydroperoxide
A4G23_RS07110	COG0800	Aldolase
A4G23_RS07125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4G23_RS07145	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4G23_RS07170	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS07175	COG1309	transcriptional regulator
A4G23_RS07195	COG3845	ABC transporter
A4G23_RS07210	COG4122	O-methyltransferase activity
A4G23_RS07230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G23_RS07245	COG4991	sh3 domain protein
A4G23_RS07260	COG1476	TRANSCRIPTIONal
A4G23_RS07335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4G23_RS07375	COG1358	cellular component organization or biogenesis
A4G23_RS07420	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4G23_RS07430	COG0477	Major facilitator Superfamily
A4G23_RS07435	COG1309	transcriptional regulator
A4G23_RS07450	COG4585	Histidine kinase
A4G23_RS07455	COG2197	response regulator
A4G23_RS07470	COG0667	Aldo Keto reductase
A4G23_RS07475	COG0789	Transcriptional regulator
A4G23_RS07485	COG1741	Belongs to the pirin family
A4G23_RS07500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G23_RS07505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4G23_RS07510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4G23_RS07545	COG2130	NADP-dependent
A4G23_RS07560	COG1077	Cell shape determining protein MreB Mrl
A4G23_RS07565	COG0318	PFAM AMP-dependent synthetase and ligase
A4G23_RS07570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4G23_RS07570	COG0825	malonyl-CoA metabolic process
A4G23_RS07575	COG1846	Transcriptional regulator
A4G23_RS07580	COG1764	response to oxidative stress
A4G23_RS07600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4G23_RS07615	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4G23_RS07660	COG1070	Carbohydrate kinase
A4G23_RS07680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G23_RS07685	COG0358	DNA primase activity
A4G23_RS07695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4G23_RS07720	COG0243	molybdopterin cofactor binding
A4G23_RS07730	COG2949	membrane
A4G23_RS07755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4G23_RS07760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4G23_RS07760	COG2146	nitrite reductase [NAD(P)H] activity
A4G23_RS07765	COG2146	nitrite reductase [NAD(P)H] activity
A4G23_RS07765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4G23_RS07785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G23_RS07785	COG0574	Belongs to the PEP-utilizing enzyme family
A4G23_RS07800	COG0423	glycine-tRNA ligase activity
A4G23_RS07805	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4G23_RS07805	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4G23_RS07815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G23_RS07825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4G23_RS07830	COG1381	Involved in DNA repair and RecF pathway recombination
A4G23_RS07845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4G23_RS07860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4G23_RS07875	COG2315	Protein conserved in bacteria
A4G23_RS07885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4G23_RS07895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G23_RS07900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4G23_RS07905	COG1234	tRNA 3'-trailer cleavage
A4G23_RS07910	COG0537	adenosine 5'-monophosphoramidase activity
A4G23_RS07920	COG2070	2-Nitropropane dioxygenase
A4G23_RS07925	COG0484	heat shock protein binding
A4G23_RS07930	COG1420	regulation of RNA biosynthetic process
A4G23_RS07955	COG0481	GTPase activity
A4G23_RS07960	COG0268	Binds directly to 16S ribosomal RNA
A4G23_RS07975	COG1234	tRNA 3'-trailer cleavage
A4G23_RS08020	COG1596	polysaccharide export
A4G23_RS08020	COG1555	photosystem II stabilization
A4G23_RS08025	COG1307	EDD domain protein, DegV family
A4G23_RS08035	COG0495	leucyl-tRNA aminoacylation
A4G23_RS08045	COG5650	phosphatidylinositol metabolic process
A4G23_RS08060	COG0588	phosphoglycerate mutase activity
A4G23_RS08065	COG0799	negative regulation of ribosome biogenesis
A4G23_RS08075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4G23_RS08080	COG0501	Belongs to the peptidase M48B family
A4G23_RS08095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4G23_RS08105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4G23_RS08120	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS08125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4G23_RS08130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4G23_RS08135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4G23_RS08155	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS08200	COG0673	inositol 2-dehydrogenase activity
A4G23_RS08210	COG1530	ribonuclease E activity
A4G23_RS08235	COG3226	Transcriptional regulator
A4G23_RS08250	COG0772	Belongs to the SEDS family
A4G23_RS08255	COG0768	penicillin binding
A4G23_RS08270	COG1077	Cell shape determining protein MreB Mrl
A4G23_RS08275	COG0105	UTP biosynthetic process
A4G23_RS08285	COG0285	dihydrofolate synthase activity
A4G23_RS08290	COG0525	valine-tRNA ligase activity
A4G23_RS08300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4G23_RS08305	COG0740	serine-type endopeptidase activity
A4G23_RS08310	COG0740	serine-type endopeptidase activity
A4G23_RS08315	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4G23_RS08335	COG3594	Acyltransferase
A4G23_RS08350	COG4552	Acetyltransferase involved in intracellular survival and related
A4G23_RS08365	COG1113	amino acid transport
A4G23_RS08370	COG1268	BioY protein
A4G23_RS08375	COG1113	amino acid transport
A4G23_RS08380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4G23_RS08385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4G23_RS08435	COG0697	spore germination
A4G23_RS08440	COG1846	Transcriptional regulator
A4G23_RS08470	COG0668	transmembrane transport
A4G23_RS08490	COG1486	melibiose metabolic process
A4G23_RS08525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4G23_RS08530	COG2346	COG2346, Truncated hemoglobins
A4G23_RS08555	COG0629	single-stranded DNA binding
A4G23_RS08640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4G23_RS08685	COG1595	DNA-templated transcription, initiation
A4G23_RS08700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G23_RS08755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4G23_RS08770	COG0673	inositol 2-dehydrogenase activity
A4G23_RS08775	COG1609	Transcriptional regulator
A4G23_RS08805	COG3250	beta-galactosidase activity
A4G23_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS08825	COG1472	Belongs to the glycosyl hydrolase 3 family
A4G23_RS08855	COG2356	endonuclease I
A4G23_RS08860	COG0028	Belongs to the TPP enzyme family
A4G23_RS08890	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4G23_RS08935	COG1946	Acyl-CoA thioesterase
A4G23_RS08960	COG1309	transcriptional regulator
A4G23_RS08965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4G23_RS08980	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS09000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A4G23_RS09020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4G23_RS09035	COG0589	response to stress
A4G23_RS09040	COG4977	sequence-specific DNA binding
A4G23_RS09045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4G23_RS09115	COG3401	FG-GAP repeat protein
A4G23_RS09120	COG4733	cellulase activity
A4G23_RS09120	COG5297	Belongs to the glycosyl hydrolase family 6
A4G23_RS09125	COG5297	Belongs to the glycosyl hydrolase family 6
A4G23_RS09165	COG0395	ABC-type sugar transport system, permease component
A4G23_RS09195	COG0588	phosphoglycerate mutase activity
A4G23_RS09240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G23_RS09250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G23_RS09255	COG0765	amino acid transport
A4G23_RS09260	COG0765	amino acid transport
A4G23_RS09265	COG1126	abc transporter atp-binding protein
A4G23_RS09315	COG0673	inositol 2-dehydrogenase activity
A4G23_RS09345	COG2733	membrane
A4G23_RS09370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G23_RS09410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4G23_RS09420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4G23_RS09425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G23_RS09430	COG1263	PTS System
A4G23_RS09435	COG1263	PTS System
A4G23_RS09440	COG1234	tRNA 3'-trailer cleavage
A4G23_RS09465	COG1113	amino acid transport
A4G23_RS09470	COG1115	amino acid carrier protein
A4G23_RS09480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A4G23_RS09490	COG1335	isochorismatase
A4G23_RS09525	COG0277	FAD linked oxidase domain protein
A4G23_RS09535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A4G23_RS09560	COG3654	unkown
A4G23_RS09630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4G23_RS09645	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4G23_RS09655	COG1678	Uncharacterized ACR, COG1678
A4G23_RS09660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4G23_RS09665	COG0776	regulation of translation
A4G23_RS09675	COG3973	AAA domain
A4G23_RS09690	COG2223	nitrite transmembrane transporter activity
A4G23_RS09695	COG0583	DNA-binding transcription factor activity
A4G23_RS09715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4G23_RS09720	COG3409	Peptidoglycan-binding domain 1 protein
A4G23_RS09720	COG0793	Belongs to the peptidase S41A family
A4G23_RS09725	COG2177	Part of the ABC transporter FtsEX involved in
A4G23_RS09730	COG2884	Cell division ATP-binding protein ftsE
A4G23_RS09745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4G23_RS09750	COG0515	serine threonine protein kinase
A4G23_RS09755	COG0515	serine threonine protein kinase
A4G23_RS09765	COG1653	transport
A4G23_RS09770	COG1175	transmembrane transport
A4G23_RS09775	COG0395	ABC-type sugar transport system, permease component
A4G23_RS09780	COG1309	transcriptional regulator
A4G23_RS09790	COG1134	teichoic acid transport
A4G23_RS09800	COG2902	Dehydrogenase
A4G23_RS09820	COG0653	protein targeting
A4G23_RS09830	COG3214	Protein conserved in bacteria
A4G23_RS09840	COG2197	response regulator
A4G23_RS09845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4G23_RS09855	COG0823	Involved in the tonB-independent uptake of proteins
A4G23_RS09860	COG5000	phosphorelay sensor kinase activity
A4G23_RS09860	COG5002	protein histidine kinase activity
A4G23_RS09865	COG0745	RESPONSE REGULATOR receiver
A4G23_RS09870	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4G23_RS09890	COG0714	Associated with various cellular activities
A4G23_RS09930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4G23_RS09940	COG1482	cell wall glycoprotein biosynthetic process
A4G23_RS09950	COG2835	tetraacyldisaccharide 4'-kinase activity
A4G23_RS09955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G23_RS09990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4G23_RS09995	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A4G23_RS09995	COG0778	Nitroreductase
A4G23_RS10020	COG1316	TRANSCRIPTIONal
A4G23_RS10025	COG1316	TRANSCRIPTIONal
A4G23_RS10030	COG1316	TRANSCRIPTIONal
A4G23_RS10035	COG1316	TRANSCRIPTIONal
A4G23_RS10040	COG1607	acyl-coa hydrolase
A4G23_RS10045	COG1316	TRANSCRIPTIONal
A4G23_RS10055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS10060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS10070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4G23_RS10090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4G23_RS10100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4G23_RS10115	COG2205	protein histidine kinase activity
A4G23_RS10120	COG0745	RESPONSE REGULATOR receiver
A4G23_RS10125	COG3104	oligopeptide transport
A4G23_RS10130	COG1316	TRANSCRIPTIONal
A4G23_RS10145	COG0297	glycogen (starch) synthase activity
A4G23_RS10185	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A4G23_RS10190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G23_RS10195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4G23_RS10205	COG1366	Belongs to the anti-sigma-factor antagonist family
A4G23_RS10210	COG1191	sigma factor activity
A4G23_RS10225	COG1228	amidohydrolase
A4G23_RS10240	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4G23_RS10245	COG0019	diaminopimelate decarboxylase activity
A4G23_RS10305	COG2755	lipolytic protein G-D-S-L family
A4G23_RS10310	COG0183	Belongs to the thiolase family
A4G23_RS10330	COG0577	efflux transmembrane transporter activity
A4G23_RS10330	COG1136	(ABC) transporter
A4G23_RS10340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4G23_RS10345	COG1252	NADH dehydrogenase
A4G23_RS10385	COG0148	phosphopyruvate hydratase activity
A4G23_RS10395	COG1652	LysM domain
A4G23_RS10400	COG2124	cytochrome p450
A4G23_RS10420	COG0463	Glycosyl transferase, family 2
A4G23_RS10440	COG1309	transcriptional regulator
A4G23_RS10445	COG2815	serine threonine protein kinase
A4G23_RS10445	COG0515	serine threonine protein kinase
A4G23_RS10535	COG4585	Histidine kinase
A4G23_RS10545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4G23_RS10550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4G23_RS10555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4G23_RS10560	COG0193	aminoacyl-tRNA hydrolase activity
A4G23_RS10575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4G23_RS10590	COG4106	trans-aconitate 2-methyltransferase activity
A4G23_RS10595	COG1846	Transcriptional regulator
A4G23_RS10600	COG2197	response regulator
A4G23_RS10605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4G23_RS10635	COG0488	(ABC) transporter
A4G23_RS10655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4G23_RS10660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4G23_RS10670	COG0084	hydrolase, TatD family'
A4G23_RS10695	COG5297	Belongs to the glycosyl hydrolase family 6
A4G23_RS10695	COG4733	cellulase activity
A4G23_RS10710	COG2409	Drug exporters of the RND superfamily
A4G23_RS10720	COG0793	Belongs to the peptidase S41A family
A4G23_RS10720	COG4946	Tricorn protease homolog
A4G23_RS10725	COG2318	DinB family
A4G23_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS10745	COG2072	flavoprotein involved in K transport
A4G23_RS10785	COG0708	Exodeoxyribonuclease III
A4G23_RS10800	COG0252	asparaginase activity
A4G23_RS10870	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4G23_RS10875	COG0315	cyclic pyranopterin monophosphate synthase activity
A4G23_RS10885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4G23_RS10890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4G23_RS10915	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4G23_RS10940	COG3191	aminopeptidase activity
A4G23_RS10950	COG0477	Major facilitator Superfamily
A4G23_RS10975	COG3384	dioxygenase
A4G23_RS10980	COG1846	Transcriptional regulator
A4G23_RS11010	COG2188	Transcriptional regulator
A4G23_RS11020	COG2188	Transcriptional regulator
A4G23_RS11130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G23_RS11135	COG1120	ATPase activity
A4G23_RS11145	COG0546	phosphoglycolate phosphatase activity
A4G23_RS11160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G23_RS11205	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A4G23_RS11220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4G23_RS11225	COG0475	glutathione-regulated potassium exporter activity
A4G23_RS11240	COG3629	intracellular signal transduction
A4G23_RS11240	COG3903	Transcriptional regulator
A4G23_RS11295	COG1695	Transcriptional regulator
A4G23_RS11315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4G23_RS11330	COG2318	DinB family
A4G23_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS11380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4G23_RS11380	COG0515	serine threonine protein kinase
A4G23_RS11390	COG1309	transcriptional regulator
A4G23_RS11400	COG2072	flavoprotein involved in K transport
A4G23_RS11425	COG1366	Belongs to the anti-sigma-factor antagonist family
A4G23_RS11475	COG1131	(ABC) transporter
A4G23_RS11485	COG0596	Alpha beta hydrolase
A4G23_RS11485	COG2945	thiolester hydrolase activity
A4G23_RS11495	COG4821	SIS domain
A4G23_RS11505	COG0259	pyridoxamine-phosphate oxidase activity
A4G23_RS11550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4G23_RS11565	COG1024	Enoyl-CoA hydratase
A4G23_RS11575	COG5006	permease, DMT superfamily
A4G23_RS11580	COG0247	lactate metabolic process
A4G23_RS11580	COG0277	FAD linked oxidase domain protein
A4G23_RS11585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4G23_RS11620	COG2175	clavaminate synthase activity
A4G23_RS11625	COG0527	aspartate kinase activity
A4G23_RS11630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4G23_RS11635	COG0697	spore germination
A4G23_RS11640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G23_RS11655	COG0583	DNA-binding transcription factor activity
A4G23_RS11675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G23_RS11680	COG0494	nUDIX hydrolase
A4G23_RS11725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4G23_RS11740	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4G23_RS11745	COG1737	Transcriptional regulator
A4G23_RS11775	COG3142	Participates in the control of copper homeostasis
A4G23_RS11800	COG1061	Type III restriction enzyme res subunit
A4G23_RS11840	COG1131	(ABC) transporter
A4G23_RS11845	COG3973	AAA domain
A4G23_RS11860	COG1278	Cold shock
A4G23_RS11870	COG2814	Major facilitator Superfamily
A4G23_RS11880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4G23_RS11885	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A4G23_RS11900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4G23_RS11910	COG2252	PERMEase
A4G23_RS11965	COG0667	Aldo Keto reductase
A4G23_RS11980	COG1115	amino acid carrier protein
A4G23_RS11995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4G23_RS12005	COG0463	Glycosyl transferase, family 2
A4G23_RS12010	COG0463	Glycosyl transferase, family 2
A4G23_RS12015	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A4G23_RS12035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4G23_RS12075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4G23_RS12105	COG2197	response regulator
A4G23_RS12130	COG3842	ATPase activity
A4G23_RS12140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4G23_RS12155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G23_RS12160	COG0215	cysteine-tRNA ligase activity
A4G23_RS12175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4G23_RS12185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4G23_RS12190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4G23_RS12195	COG1329	Transcriptional regulator
A4G23_RS12210	COG5002	protein histidine kinase activity
A4G23_RS12240	COG0588	phosphoglycerate mutase activity
A4G23_RS12255	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS12350	COG3973	AAA domain
A4G23_RS12375	COG4552	Acetyltransferase involved in intracellular survival and related
A4G23_RS12385	COG1490	D-aminoacyl-tRNA deacylase activity
A4G23_RS12400	COG3485	protocatechuate 3,4-dioxygenase
A4G23_RS12435	COG2897	thiosulfate sulfurtransferase activity
A4G23_RS12460	COG0745	RESPONSE REGULATOR receiver
A4G23_RS12465	COG1609	Transcriptional regulator
A4G23_RS12470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G23_RS12485	COG0737	Belongs to the 5'-nucleotidase family
A4G23_RS12490	COG0456	acetyltransferase
A4G23_RS12520	COG0406	alpha-ribazole phosphatase activity
A4G23_RS12520	COG0494	nUDIX hydrolase
A4G23_RS12525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4G23_RS12545	COG0306	phosphate transporter
A4G23_RS12555	COG1937	Protein conserved in bacteria
A4G23_RS12575	COG0671	phosphoesterase, PA-phosphatase related
A4G23_RS12580	COG0739	heme binding
A4G23_RS12580	COG0741	lytic transglycosylase activity
A4G23_RS12580	COG1196	nuclear chromosome segregation
A4G23_RS12655	COG1131	(ABC) transporter
A4G23_RS12665	COG4585	Histidine kinase
A4G23_RS12670	COG2197	response regulator
A4G23_RS12675	COG0789	Transcriptional regulator
A4G23_RS12745	COG0579	oxidoreductase
A4G23_RS12750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4G23_RS12760	COG0741	lytic transglycosylase activity
A4G23_RS12760	COG1196	nuclear chromosome segregation
A4G23_RS12760	COG0739	heme binding
A4G23_RS12780	COG0513	Belongs to the DEAD box helicase family
A4G23_RS12825	COG0785	Cytochrome C biogenesis protein
A4G23_RS12830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4G23_RS12830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G23_RS12840	COG1643	Atp-dependent helicase
A4G23_RS12875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4G23_RS12895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4G23_RS12900	COG0047	phosphoribosylformylglycinamidine synthase activity
A4G23_RS12905	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4G23_RS12935	COG4585	Histidine kinase
A4G23_RS12940	COG2197	response regulator
A4G23_RS12950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4G23_RS12965	COG0151	Belongs to the GarS family
A4G23_RS13060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G23_RS13070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4G23_RS13080	COG0628	permease
A4G23_RS13085	COG1741	Belongs to the pirin family
A4G23_RS13115	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS13120	COG1362	aminopeptidase activity
A4G23_RS13145	COG0477	Major facilitator Superfamily
A4G23_RS13155	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G23_RS13160	COG0022	dehydrogenase e1 component
A4G23_RS13175	COG0515	serine threonine protein kinase
A4G23_RS13180	COG0515	serine threonine protein kinase
A4G23_RS13195	COG1136	(ABC) transporter
A4G23_RS13195	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G23_RS13215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4G23_RS13220	COG0303	'Molybdopterin
A4G23_RS13245	COG1522	sequence-specific DNA binding
A4G23_RS13250	COG1309	transcriptional regulator
A4G23_RS13255	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4G23_RS13280	COG3396	Phenylacetate-CoA oxygenase
A4G23_RS13285	COG3460	Phenylacetate-CoA oxygenase
A4G23_RS13290	COG3396	Phenylacetate-CoA oxygenase
A4G23_RS13295	COG2151	metal-sulfur cluster biosynthetic enzyme
A4G23_RS13300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4G23_RS13325	COG1716	ATPase activity
A4G23_RS13330	COG1716	ATPase activity
A4G23_RS13345	COG0768	penicillin binding
A4G23_RS13350	COG0515	serine threonine protein kinase
A4G23_RS13355	COG3764	Sortase (surface protein transpeptidase)
A4G23_RS13360	COG3764	Sortase (surface protein transpeptidase)
A4G23_RS13380	COG0705	Rhomboid family
A4G23_RS13415	COG0515	serine threonine protein kinase
A4G23_RS13440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G23_RS13450	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A4G23_RS13455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4G23_RS13460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A4G23_RS13465	COG0592	DNA-directed DNA polymerase activity
A4G23_RS13475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4G23_RS13480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4G23_RS13485	COG0706	membrane insertase activity
A4G23_RS13495	COG0357	Ribosomal RNA small subunit methyltransferase G
A4G23_RS13500	COG1192	Involved in chromosome partitioning
A4G23_RS13515	COG3118	belongs to the thioredoxin family
A4G23_RS13520	COG0492	ferredoxin-NADP+ reductase activity
A4G23_RS13530	COG1595	DNA-templated transcription, initiation
A4G23_RS13535	COG0515	serine threonine protein kinase
A4G23_RS13535	COG2815	serine threonine protein kinase
A4G23_RS13550	COG0617	tRNA 3'-terminal CCA addition
A4G23_RS13560	COG1260	myo-inositol-1-phosphate synthase
A4G23_RS13570	COG4499	WXG100 protein secretion system (Wss), protein YukC
A4G23_RS13570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G23_RS13595	COG0360	Binds together with S18 to 16S ribosomal RNA
A4G23_RS13600	COG0629	single-stranded DNA binding
A4G23_RS13605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4G23_RS13610	COG0359	binds to the 23S rRNA
A4G23_RS13620	COG0305	Participates in initiation and elongation during chromosome replication
A4G23_RS13650	COG0626	cystathionine gamma-synthase activity
A4G23_RS13655	COG1950	PFAM Membrane protein of
A4G23_RS13660	COG0662	Cupin 2, conserved barrel domain protein
A4G23_RS13685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4G23_RS13700	COG1609	Transcriptional regulator
A4G23_RS13705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4G23_RS13710	COG1271	oxidase subunit
A4G23_RS13715	COG1294	oxidase, subunit
A4G23_RS13720	COG4988	ABC transporter
A4G23_RS13725	COG0739	heme binding
A4G23_RS13725	COG0741	lytic transglycosylase activity
A4G23_RS13725	COG1196	nuclear chromosome segregation
A4G23_RS13730	COG0561	phosphatase activity
A4G23_RS13740	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A4G23_RS13745	COG0789	Transcriptional regulator
A4G23_RS13765	COG1131	(ABC) transporter
A4G23_RS13780	COG0561	phosphatase activity
A4G23_RS13785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4G23_RS13795	COG2837	iron assimilation
A4G23_RS13800	COG2372	response to copper ion
A4G23_RS13810	COG1999	signal sequence binding
A4G23_RS13830	COG0006	proline dipeptidase activity
A4G23_RS13845	COG0653	protein targeting
A4G23_RS13860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G23_RS13870	COG1595	DNA-templated transcription, initiation
A4G23_RS13875	COG0318	PFAM AMP-dependent synthetase and ligase
A4G23_RS13915	COG0745	RESPONSE REGULATOR receiver
A4G23_RS13920	COG0477	Major facilitator Superfamily
A4G23_RS13945	COG1191	sigma factor activity
A4G23_RS13950	COG1191	sigma factor activity
A4G23_RS13980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4G23_RS14005	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A4G23_RS14025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4G23_RS14080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4G23_RS14085	COG1993	acr, cog1993
A4G23_RS14090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4G23_RS14145	COG1881	PFAM PEBP family protein
A4G23_RS14160	COG0142	geranyltranstransferase activity
A4G23_RS14170	COG1595	DNA-templated transcription, initiation
A4G23_RS14205	COG1278	Cold shock
A4G23_RS14225	COG3866	Pectate lyase
A4G23_RS14260	COG2197	response regulator
A4G23_RS14265	COG3851	Histidine kinase
A4G23_RS14275	COG3263	regulation of cellular component size
A4G23_RS14280	COG1253	flavin adenine dinucleotide binding
A4G23_RS14300	COG4326	sporulation control protein
A4G23_RS14390	COG0717	Belongs to the dCTP deaminase family
A4G23_RS14405	COG0247	lactate metabolic process
A4G23_RS14405	COG2181	nitrate reductase activity
A4G23_RS14410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4G23_RS14415	COG0443	Heat shock 70 kDa protein
A4G23_RS14420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4G23_RS14425	COG0484	heat shock protein binding
A4G23_RS14430	COG0789	Transcriptional regulator
A4G23_RS14460	COG0542	response to heat
A4G23_RS14490	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A4G23_RS14505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4G23_RS14510	COG0191	fructose-bisphosphate aldolase activity
A4G23_RS14515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4G23_RS14540	COG3844	kynureninase activity
A4G23_RS14550	COG4585	Histidine kinase
A4G23_RS14555	COG2197	response regulator
A4G23_RS14570	COG3559	Exporter of polyketide antibiotics
A4G23_RS14575	COG1131	(ABC) transporter
A4G23_RS14590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4G23_RS14605	COG0604	alcohol dehydrogenase
A4G23_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS14605	COG3321	synthase
A4G23_RS14630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G23_RS14635	COG1309	transcriptional regulator
A4G23_RS14690	COG2890	protein-(glutamine-N5) methyltransferase activity
A4G23_RS14695	COG0693	protein deglycase activity
A4G23_RS14700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4G23_RS14705	COG1802	Transcriptional regulator
A4G23_RS14720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4G23_RS14725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4G23_RS14740	COG1595	DNA-templated transcription, initiation
A4G23_RS14790	COG1408	metallophosphoesterase
A4G23_RS14795	COG1610	YqeY-like protein
A4G23_RS14800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4G23_RS14830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G23_RS14865	COG2267	carboxylic ester hydrolase activity
A4G23_RS14875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4G23_RS14880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4G23_RS14935	COG1111	helicase
A4G23_RS14935	COG1205	dead DEAH box helicase
A4G23_RS14940	COG1366	Belongs to the anti-sigma-factor antagonist family
A4G23_RS14945	COG2172	sigma factor antagonist activity
A4G23_RS14950	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A4G23_RS14960	COG2890	protein-(glutamine-N5) methyltransferase activity
A4G23_RS14970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4G23_RS14970	COG1754	DNA topoisomerase type I activity
A4G23_RS14975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4G23_RS14980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4G23_RS14995	COG0596	Alpha beta hydrolase
A4G23_RS15000	COG2267	carboxylic ester hydrolase activity
A4G23_RS15010	COG1733	regulation of RNA biosynthetic process
A4G23_RS15015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4G23_RS15020	COG1280	lysine exporter protein (LysE YggA)
A4G23_RS15065	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS15090	COG0438	transferase activity, transferring glycosyl groups
A4G23_RS15115	COG0492	ferredoxin-NADP+ reductase activity
A4G23_RS15150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G23_RS15150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G23_RS15170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4G23_RS15175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4G23_RS15180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4G23_RS15185	COG0254	rRNA binding
A4G23_RS15195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4G23_RS15215	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS15220	COG2318	DinB family
A4G23_RS15230	COG0789	Transcriptional regulator
A4G23_RS15235	COG0586	Pfam SNARE associated Golgi protein
A4G23_RS15245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4G23_RS15250	COG2027	D-alanyl-D-alanine carboxypeptidase
A4G23_RS15260	COG0037	tRNA processing
A4G23_RS15275	COG0302	gtp cyclohydrolase
A4G23_RS15290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4G23_RS15305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4G23_RS15305	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4G23_RS15320	COG1174	glycine betaine transport
A4G23_RS15325	COG1174	glycine betaine transport
A4G23_RS15340	COG0649	NAD binding
A4G23_RS15355	COG2197	response regulator
A4G23_RS15360	COG1660	Displays ATPase and GTPase activities
A4G23_RS15370	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A4G23_RS15380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4G23_RS15385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4G23_RS15395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4G23_RS15415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4G23_RS15435	COG2027	D-alanyl-D-alanine carboxypeptidase
A4G23_RS15440	COG0739	heme binding
A4G23_RS15445	COG2205	protein histidine kinase activity
A4G23_RS15450	COG0745	RESPONSE REGULATOR receiver
A4G23_RS15460	COG1595	DNA-templated transcription, initiation
A4G23_RS15465	COG1194	a g-specific adenine glycosylase
A4G23_RS15480	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A4G23_RS15500	COG0248	Ppx GppA phosphatase
A4G23_RS15505	COG1082	Xylose isomerase domain protein TIM barrel
A4G23_RS15510	COG0129	dihydroxy-acid dehydratase activity
A4G23_RS15520	COG4991	sh3 domain protein
A4G23_RS15530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4G23_RS15535	COG1335	isochorismatase
A4G23_RS15545	COG0180	Tryptophanyl-tRNA synthetase
A4G23_RS15570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G23_RS15620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4G23_RS15625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4G23_RS15630	COG0181	hydroxymethylbilane synthase activity
A4G23_RS15635	COG1648	precorrin-2 dehydrogenase activity
A4G23_RS15635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4G23_RS15685	COG2318	DinB family
A4G23_RS15710	COG0596	Alpha beta hydrolase
A4G23_RS15715	COG0113	porphobilinogen synthase activity
A4G23_RS15725	COG1595	DNA-templated transcription, initiation
A4G23_RS15755	COG0515	serine threonine protein kinase
A4G23_RS15755	COG2815	serine threonine protein kinase
A4G23_RS15760	COG0018	arginyl-trna synthetase
A4G23_RS15765	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A4G23_RS15785	COG1690	Belongs to the RtcB family
A4G23_RS15810	COG0477	Major facilitator Superfamily
A4G23_RS15820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4G23_RS15825	COG0406	alpha-ribazole phosphatase activity
A4G23_RS15845	COG1333	cytochrome c biogenesis protein
A4G23_RS15850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G23_RS15870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4G23_RS15890	COG0163	prenyltransferase activity
A4G23_RS15905	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4G23_RS15920	COG1301	dicarboxylic acid transport
A4G23_RS15970	COG0501	Belongs to the peptidase M48B family
A4G23_RS15980	COG1278	Cold shock
A4G23_RS15985	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A4G23_RS16000	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4G23_RS16010	COG2226	methyltransferase
A4G23_RS16015	COG2226	methyltransferase
A4G23_RS16050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4G23_RS16055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4G23_RS16060	COG0649	NAD binding
A4G23_RS16070	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4G23_RS16075	COG1034	ATP synthesis coupled electron transport
A4G23_RS16080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4G23_RS16085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4G23_RS16090	COG0839	Belongs to the complex I subunit 6 family
A4G23_RS16095	COG0713	ATP synthesis coupled electron transport
A4G23_RS16100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4G23_RS16110	COG1007	ATP synthesis coupled electron transport
A4G23_RS16120	COG2207	Transcriptional regulator
A4G23_RS16130	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4G23_RS16135	COG0142	geranyltranstransferase activity
A4G23_RS16145	COG2234	aminopeptidase activity
A4G23_RS16145	COG4935	Belongs to the peptidase S8 family
A4G23_RS16160	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4G23_RS16165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4G23_RS16165	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4G23_RS16185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4G23_RS16190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4G23_RS16195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4G23_RS16200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4G23_RS16205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4G23_RS16210	COG0839	Belongs to the complex I subunit 6 family
A4G23_RS16215	COG0713	ATP synthesis coupled electron transport
A4G23_RS16220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4G23_RS16230	COG1007	ATP synthesis coupled electron transport
A4G23_RS16235	COG0501	Belongs to the peptidase M48B family
A4G23_RS16240	COG3304	Inner membrane component domain
A4G23_RS16255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4G23_RS16260	COG1666	GTP binding
A4G23_RS16270	COG0702	epimerase
A4G23_RS16290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4G23_RS16295	COG2030	dehydratase
A4G23_RS16305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4G23_RS16310	COG1595	DNA-templated transcription, initiation
A4G23_RS16320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4G23_RS16325	COG0436	Aminotransferase
A4G23_RS16345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4G23_RS16350	COG0081	regulation of translation
A4G23_RS16365	COG0222	ribosome binding
A4G23_RS16370	COG0085	RNA polymerase activity
A4G23_RS16375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4G23_RS16495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4G23_RS16500	COG0049	tRNA binding
A4G23_RS16505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4G23_RS16510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4G23_RS16540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4G23_RS16600	COG0051	transcription antitermination factor activity, RNA binding
A4G23_RS16605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4G23_RS16610	COG0088	Forms part of the polypeptide exit tunnel
A4G23_RS16615	COG0089	rRNA binding
A4G23_RS16620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4G23_RS16625	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4G23_RS16630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4G23_RS16635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4G23_RS16640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4G23_RS16645	COG0255	Belongs to the universal ribosomal protein uL29 family
A4G23_RS16650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4G23_RS16655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4G23_RS16660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4G23_RS16665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4G23_RS16670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4G23_RS16675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4G23_RS16680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4G23_RS16685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4G23_RS16690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4G23_RS16695	COG1841	ribosomal large subunit assembly
A4G23_RS16700	COG0200	Binds to the 23S rRNA
A4G23_RS16705	COG0201	protein transport
A4G23_RS16710	COG0563	adenylate kinase activity
A4G23_RS16720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4G23_RS16725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4G23_RS16730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4G23_RS16735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4G23_RS16740	COG0202	RNA polymerase activity
A4G23_RS16745	COG0203	ribosomal protein L17
A4G23_RS16750	COG0101	tRNA pseudouridine synthase activity
A4G23_RS16765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4G23_RS16770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4G23_RS16775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G23_RS16780	COG1072	(Pantothenic acid kinase))
A4G23_RS16785	COG2161	toxin-antitoxin pair type II binding
A4G23_RS16790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4G23_RS16795	COG0736	holo-[acyl-carrier-protein] synthase activity
A4G23_RS16805	COG0596	Alpha beta hydrolase
A4G23_RS16860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4G23_RS16870	COG0802	atpase or kinase
A4G23_RS16895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4G23_RS16915	COG0726	polysaccharide deacetylase
A4G23_RS16920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4G23_RS16935	COG0583	DNA-binding transcription factor activity
A4G23_RS16940	COG4221	oxidoreductase activity
A4G23_RS16950	COG0583	DNA-binding transcription factor activity
A4G23_RS16960	COG2197	response regulator
A4G23_RS16965	COG1595	DNA-templated transcription, initiation
A4G23_RS16975	COG0516	GMP reductase activity
A4G23_RS16990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4G23_RS17005	COG0515	serine threonine protein kinase
A4G23_RS17010	COG0515	serine threonine protein kinase
A4G23_RS17010	COG2815	serine threonine protein kinase
A4G23_RS17015	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS17065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4G23_RS17065	COG0519	Catalyzes the synthesis of GMP from XMP
A4G23_RS17085	COG2197	response regulator
A4G23_RS17115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS17115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS17135	COG0714	Associated with various cellular activities
A4G23_RS17145	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4G23_RS17155	COG0045	succinate-CoA ligase (ADP-forming) activity
A4G23_RS17205	COG0138	bifunctional purine biosynthesis protein purh
A4G23_RS17240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4G23_RS17255	COG0039	L-malate dehydrogenase activity
A4G23_RS17260	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS17270	COG4175	Glycine betaine
A4G23_RS17270	COG0517	IMP dehydrogenase activity
A4G23_RS17275	COG4176	ABC-type proline glycine betaine transport system permease component
A4G23_RS17290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4G23_RS17295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4G23_RS17305	COG0754	glutathionylspermidine amidase activity
A4G23_RS17310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G23_RS17315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4G23_RS17320	COG0180	Tryptophanyl-tRNA synthetase
A4G23_RS17330	COG1295	ribonuclease BN
A4G23_RS17335	COG1686	Belongs to the peptidase S11 family
A4G23_RS17345	COG1408	metallophosphoesterase
A4G23_RS17350	COG4166	transmembrane transport
A4G23_RS17365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4G23_RS17370	COG1053	succinate dehydrogenase
A4G23_RS17380	COG2009	succinate dehydrogenase
A4G23_RS17390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4G23_RS17410	COG1834	amidinotransferase
A4G23_RS17425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4G23_RS17430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4G23_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS17450	COG0546	phosphoglycolate phosphatase activity
A4G23_RS17465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G23_RS17490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G23_RS17505	COG1595	DNA-templated transcription, initiation
A4G23_RS17520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS17520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS17540	COG1216	Glycosyl transferase, family 2
A4G23_RS17550	COG1083	cytidylyl-transferase
A4G23_RS17555	COG2089	acid synthase
A4G23_RS17565	COG1473	amidohydrolase
A4G23_RS17565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4G23_RS17570	COG1396	sequence-specific DNA binding
A4G23_RS17575	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
A4G23_RS17580	COG1744	ABC transporter substrate-binding protein PnrA-like
A4G23_RS17585	COG3845	ABC transporter
A4G23_RS17595	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4G23_RS17625	COG2814	Major facilitator Superfamily
A4G23_RS17630	COG0583	DNA-binding transcription factor activity
A4G23_RS17640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4G23_RS17665	COG2205	protein histidine kinase activity
A4G23_RS17670	COG0745	RESPONSE REGULATOR receiver
A4G23_RS17675	COG1595	DNA-templated transcription, initiation
A4G23_RS17690	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS17695	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS17700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4G23_RS17705	COG3973	AAA domain
A4G23_RS17725	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS17785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G23_RS17830	COG4770	biotin carboxylase activity
A4G23_RS17840	COG0424	maF-like protein
A4G23_RS17850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4G23_RS17865	COG1024	Enoyl-CoA hydratase
A4G23_RS17875	COG2986	histidine ammonia-lyase
A4G23_RS17890	COG1376	ErfK ybiS ycfS ynhG family protein
A4G23_RS17905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4G23_RS17920	COG0501	Belongs to the peptidase M48B family
A4G23_RS17950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4G23_RS17965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4G23_RS17975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4G23_RS17995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4G23_RS18005	COG1331	Highly conserved protein containing a thioredoxin domain
A4G23_RS18025	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4G23_RS18045	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A4G23_RS18060	COG1414	Transcriptional regulator
A4G23_RS18145	COG2885	chlorophyll binding
A4G23_RS18165	COG0667	Aldo Keto reductase
A4G23_RS18170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4G23_RS18175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4G23_RS18195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4G23_RS18200	COG0450	alkyl hydroperoxide reductase
A4G23_RS18225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G23_RS18240	COG0114	fumarate hydratase activity
A4G23_RS18250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4G23_RS18250	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4G23_RS18280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4G23_RS18285	COG1570	exodeoxyribonuclease VII activity
A4G23_RS18290	COG1722	exodeoxyribonuclease VII activity
A4G23_RS18295	COG0778	Nitroreductase
A4G23_RS18305	COG0012	GTP binding
A4G23_RS18360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4G23_RS18405	COG1217	gtp-binding protein TYPA
A4G23_RS18410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G23_RS18415	COG4166	transmembrane transport
A4G23_RS18420	COG0601	transmembrane transport
A4G23_RS18425	COG0444	Belongs to the ABC transporter superfamily
A4G23_RS18430	COG4608	Belongs to the ABC transporter superfamily
A4G23_RS18435	COG4166	transmembrane transport
A4G23_RS18440	COG0601	transmembrane transport
A4G23_RS18445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G23_RS18450	COG0444	Belongs to the ABC transporter superfamily
A4G23_RS18455	COG4608	Belongs to the ABC transporter superfamily
A4G23_RS18475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4G23_RS18520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G23_RS18525	COG1611	Belongs to the LOG family
A4G23_RS18530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4G23_RS18540	COG0519	Catalyzes the synthesis of GMP from XMP
A4G23_RS18545	COG1024	Enoyl-CoA hydratase
A4G23_RS18560	COG1595	DNA-templated transcription, initiation
A4G23_RS18570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G23_RS18575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G23_RS18610	COG0598	Magnesium transport protein CorA
A4G23_RS18630	COG2095	MarC family integral membrane protein
A4G23_RS18635	COG1432	Conserved Protein
A4G23_RS18675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4G23_RS18675	COG0596	Alpha beta hydrolase
A4G23_RS18755	COG0210	DNA helicase
A4G23_RS18760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G23_RS18795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4G23_RS18855	COG3480	Lon protease (S16) C-terminal proteolytic domain
A4G23_RS18865	COG1615	UPF0182 protein
A4G23_RS18890	COG0753	catalase activity
A4G23_RS18895	COG0483	inositol monophosphate 1-phosphatase activity
A4G23_RS18900	COG2076	Multidrug Resistance protein
A4G23_RS18910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4G23_RS18920	COG2135	peptidase activity
A4G23_RS18930	COG1595	DNA-templated transcription, initiation
A4G23_RS18935	COG5662	AntiSigma factor
A4G23_RS18940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A4G23_RS18940	COG2199	diguanylate cyclase activity
A4G23_RS18955	COG0242	peptide deformylase activity
A4G23_RS18965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G23_RS18985	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4G23_RS19005	COG2188	Transcriptional regulator
A4G23_RS19010	COG2182	Extracellular solute-binding protein
A4G23_RS19015	COG1175	transmembrane transport
A4G23_RS19020	COG0395	ABC-type sugar transport system, permease component
A4G23_RS19025	COG1472	Belongs to the glycosyl hydrolase 3 family
A4G23_RS19030	COG0363	glucosamine-6-phosphate deaminase activity
A4G23_RS19045	COG1597	lipid kinase activity
A4G23_RS19065	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A4G23_RS19070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G23_RS19075	COG0142	geranyltranstransferase activity
A4G23_RS19090	COG5640	endopeptidase activity
A4G23_RS19115	COG1136	(ABC) transporter
A4G23_RS19140	COG1126	abc transporter atp-binding protein
A4G23_RS19175	COG0515	serine threonine protein kinase
A4G23_RS19185	COG0604	alcohol dehydrogenase
A4G23_RS19215	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G23_RS19215	COG0567	Dehydrogenase, E1 component
A4G23_RS19220	COG2205	protein histidine kinase activity
A4G23_RS19225	COG0745	RESPONSE REGULATOR receiver
A4G23_RS19245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4G23_RS19255	COG3227	Zinc metalloprotease (Elastase)
A4G23_RS19260	COG2197	response regulator
A4G23_RS19265	COG4585	Histidine kinase
A4G23_RS19320	COG2197	response regulator
A4G23_RS19325	COG4585	Histidine kinase
A4G23_RS19335	COG1136	(ABC) transporter
A4G23_RS19360	COG0768	penicillin binding
A4G23_RS19370	COG2205	protein histidine kinase activity
A4G23_RS19390	COG1793	dna ligase
A4G23_RS19395	COG1793	dna ligase
A4G23_RS19395	COG3285	dna ligase
A4G23_RS19400	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4G23_RS19430	COG1653	transport
A4G23_RS19445	COG1192	Involved in chromosome partitioning
A4G23_RS19460	COG0745	RESPONSE REGULATOR receiver
A4G23_RS19465	COG0018	arginyl-trna synthetase
A4G23_RS19470	COG0019	diaminopimelate decarboxylase activity
A4G23_RS19475	COG0460	homoserine dehydrogenase
A4G23_RS19480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4G23_RS19485	COG0083	homoserine kinase activity
A4G23_RS19500	COG1316	TRANSCRIPTIONal
A4G23_RS19505	COG0254	rRNA binding
A4G23_RS19510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4G23_RS19515	COG2890	protein-(glutamine-N5) methyltransferase activity
A4G23_RS19525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4G23_RS19530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4G23_RS19550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4G23_RS19555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4G23_RS19560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4G23_RS19565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4G23_RS19570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4G23_RS19575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4G23_RS19580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4G23_RS19595	COG2197	response regulator
A4G23_RS19600	COG4585	Histidine kinase
A4G23_RS19615	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4G23_RS19630	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A4G23_RS19665	COG1131	(ABC) transporter
A4G23_RS19685	COG0183	Belongs to the thiolase family
A4G23_RS19740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS19740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS19780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4G23_RS19785	COG0280	phosphate acetyltransferase
A4G23_RS19785	COG0857	belongs to the CobB CobQ family
A4G23_RS19790	COG0205	6-phosphofructokinase activity
A4G23_RS19805	COG4565	transcriptional regulatory protein
A4G23_RS19810	COG3290	protein histidine kinase activity
A4G23_RS19815	COG1301	dicarboxylic acid transport
A4G23_RS19830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4G23_RS19835	COG3281	Trehalose synthase
A4G23_RS19840	COG0366	Alpha amylase catalytic
A4G23_RS19845	COG0366	Alpha amylase catalytic
A4G23_RS19850	COG0058	SHG alpha-glucan phosphorylase activity
A4G23_RS19860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4G23_RS19865	COG1132	(ABC) transporter
A4G23_RS19870	COG1132	(ABC) transporter
A4G23_RS19885	COG1376	ErfK ybiS ycfS ynhG family protein
A4G23_RS19915	COG2197	response regulator
A4G23_RS19940	COG1760	l-serine dehydratase
A4G23_RS19945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4G23_RS19950	COG0509	glycine decarboxylation via glycine cleavage system
A4G23_RS19955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4G23_RS19980	COG0747	negative chemotaxis
A4G23_RS19985	COG0601	transmembrane transport
A4G23_RS19990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G23_RS19995	COG0444	Belongs to the ABC transporter superfamily
A4G23_RS20000	COG4608	Belongs to the ABC transporter superfamily
A4G23_RS20005	COG2860	membrane
A4G23_RS20040	COG0482	sulfurtransferase activity
A4G23_RS20060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4G23_RS20070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4G23_RS20075	COG0154	amidase activity
A4G23_RS20085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4G23_RS20090	COG2409	Drug exporters of the RND superfamily
A4G23_RS20095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4G23_RS20100	COG2133	pyrroloquinoline quinone binding
A4G23_RS20105	COG0667	Aldo Keto reductase
A4G23_RS20125	COG0440	acetolactate synthase activity
A4G23_RS20130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4G23_RS20140	COG3835	regulator
A4G23_RS20145	COG0506	proline dehydrogenase activity
A4G23_RS20150	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS20165	COG0473	3-isopropylmalate dehydrogenase activity
A4G23_RS20170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G23_RS20175	COG0832	Belongs to the urease beta subunit family
A4G23_RS20175	COG0831	urea catabolic process
A4G23_RS20180	COG0804	urea catabolic process
A4G23_RS20185	COG2957	Belongs to the agmatine deiminase family
A4G23_RS20200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4G23_RS20215	COG2353	YceI-like domain
A4G23_RS20220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4G23_RS20240	COG2018	Roadblock/LC7 domain
A4G23_RS20260	COG2018	Roadblock/LC7 domain
A4G23_RS20265	COG5002	protein histidine kinase activity
A4G23_RS20275	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4G23_RS20280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4G23_RS20285	COG1011	Hydrolase
A4G23_RS20315	COG1414	Transcriptional regulator
A4G23_RS20320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4G23_RS20325	COG0066	3-isopropylmalate dehydratase activity
A4G23_RS20335	COG0776	regulation of translation
A4G23_RS20345	COG1920	GTP binding
A4G23_RS20355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4G23_RS20360	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G23_RS20380	COG0351	phosphomethylpyrimidine kinase
A4G23_RS20385	COG1461	Dihydroxyacetone kinase
A4G23_RS20395	COG0742	ribosomal rna small subunit methyltransferase
A4G23_RS20400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4G23_RS20415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4G23_RS20420	COG0571	ribonuclease III activity
A4G23_RS20425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4G23_RS20430	COG2340	Cysteine-rich secretory protein family
A4G23_RS20435	COG1254	Belongs to the acylphosphatase family
A4G23_RS20450	COG0477	Major facilitator Superfamily
A4G23_RS20480	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4G23_RS20500	COG0228	four-way junction DNA binding
A4G23_RS20505	COG1837	Belongs to the UPF0109 family
A4G23_RS20510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4G23_RS20515	COG0336	Belongs to the RNA methyltransferase TrmD family
A4G23_RS20520	COG0335	large ribosomal subunit rRNA binding
A4G23_RS20525	COG0681	Belongs to the peptidase S26 family
A4G23_RS20530	COG0681	Belongs to the peptidase S26 family
A4G23_RS20540	COG0681	Belongs to the peptidase S26 family
A4G23_RS20545	COG1051	belongs to the nudix hydrolase family
A4G23_RS20555	COG0792	nuclease activity
A4G23_RS20570	COG1191	sigma factor activity
A4G23_RS20585	COG0052	Belongs to the universal ribosomal protein uS2 family
A4G23_RS20590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4G23_RS20595	COG0528	UMP kinase activity
A4G23_RS20600	COG0233	cytoplasmic translational termination
A4G23_RS20610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4G23_RS20620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4G23_RS20625	COG3842	ATPase activity
A4G23_RS20630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4G23_RS20645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4G23_RS20655	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS20660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4G23_RS20675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4G23_RS20700	COG3842	ATPase activity
A4G23_RS20705	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4G23_RS20710	COG1177	transmembrane transport
A4G23_RS20715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G23_RS20745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G23_RS20750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4G23_RS20755	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS20765	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G23_RS20815	COG2508	Transcriptional regulator
A4G23_RS20820	COG0697	spore germination
A4G23_RS20825	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS20835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4G23_RS20840	COG0750	zinc metalloprotease
A4G23_RS20845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4G23_RS20860	COG0442	prolyl-tRNA aminoacylation
A4G23_RS20865	COG0330	HflC and HflK could
A4G23_RS20885	COG0779	Required for maturation of 30S ribosomal subunits
A4G23_RS20895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4G23_RS20905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4G23_RS20910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4G23_RS20925	COG0455	bacterial-type flagellum organization
A4G23_RS20945	COG3266	domain, Protein
A4G23_RS20950	COG1404	Belongs to the peptidase S8 family
A4G23_RS20965	COG1404	Belongs to the peptidase S8 family
A4G23_RS20980	COG1674	ftsk spoiiie
A4G23_RS20990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4G23_RS20995	COG1185	polyribonucleotide nucleotidyltransferase activity
A4G23_RS21000	COG0612	Peptidase, M16
A4G23_RS21005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4G23_RS21025	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A4G23_RS21030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G23_RS21035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4G23_RS21060	COG2770	Histidine kinase
A4G23_RS21060	COG2208	phosphoserine phosphatase activity
A4G23_RS21075	COG1674	ftsk spoiiie
A4G23_RS21085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G23_RS21095	COG1058	Belongs to the CinA family
A4G23_RS21095	COG1546	Belongs to the CinA family
A4G23_RS21100	COG1396	sequence-specific DNA binding
A4G23_RS21105	COG0783	Belongs to the Dps family
A4G23_RS21115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4G23_RS21120	COG1201	RNA secondary structure unwinding
A4G23_RS21125	COG2207	Transcriptional regulator
A4G23_RS21125	COG1917	Cupin 2, conserved barrel domain protein
A4G23_RS21160	COG1271	oxidase subunit
A4G23_RS21165	COG2197	response regulator
A4G23_RS21170	COG4585	Histidine kinase
A4G23_RS21185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G23_RS21190	COG0765	amino acid transport
A4G23_RS21195	COG0765	amino acid transport
A4G23_RS21200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G23_RS21205	COG1126	abc transporter atp-binding protein
A4G23_RS21210	COG0745	RESPONSE REGULATOR receiver
A4G23_RS21215	COG2205	protein histidine kinase activity
A4G23_RS21225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G23_RS21245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4G23_RS21255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4G23_RS21260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G23_RS21270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4G23_RS21285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4G23_RS21290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4G23_RS21295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G23_RS21315	COG0488	(ABC) transporter
A4G23_RS21325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4G23_RS21350	COG0477	Major facilitator Superfamily
A4G23_RS21380	COG2186	Transcriptional regulator
A4G23_RS21385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G23_RS21410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G23_RS21415	COG0612	Peptidase, M16
A4G23_RS21425	COG0739	heme binding
A4G23_RS21430	COG1802	Transcriptional regulator
A4G23_RS21435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G23_RS21455	COG1435	thymidine kinase activity
A4G23_RS21485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A4G23_RS21500	COG0745	RESPONSE REGULATOR receiver
A4G23_RS21505	COG2205	protein histidine kinase activity
A4G23_RS21530	COG0756	dUTP diphosphatase activity
A4G23_RS21565	COG0569	domain protein
A4G23_RS21570	COG0531	amino acid
A4G23_RS21575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4G23_RS21595	COG2197	response regulator
A4G23_RS21610	COG1509	lysine 2,3-aminomutase activity
A4G23_RS21620	COG3251	PFAM MbtH domain protein
A4G23_RS21630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4G23_RS21635	COG2423	ornithine cyclodeaminase activity
A4G23_RS21640	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS21645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS21680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4G23_RS21700	COG2801	Transposase and inactivated derivatives
A4G23_RS21750	COG1278	Cold shock
A4G23_RS21755	COG0513	Belongs to the DEAD box helicase family
A4G23_RS21860	COG2124	cytochrome p450
A4G23_RS21865	COG2124	cytochrome p450
A4G23_RS21925	COG0110	maltose O-acetyltransferase activity
A4G23_RS21965	COG1309	transcriptional regulator
A4G23_RS22005	COG1175	transmembrane transport
A4G23_RS22010	COG0395	ABC-type sugar transport system, permease component
A4G23_RS22030	COG2255	four-way junction helicase activity
A4G23_RS22035	COG2824	Alkylphosphonate utilization operon protein PhnA
A4G23_RS22045	COG0659	secondary active sulfate transmembrane transporter activity
A4G23_RS22055	COG0644	oxidoreductase
A4G23_RS22070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS22070	COG4221	oxidoreductase activity
A4G23_RS22070	COG3321	synthase
A4G23_RS22070	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS22080	COG4335	DNA alkylation repair
A4G23_RS22105	COG0477	Major facilitator Superfamily
A4G23_RS22120	COG1309	transcriptional regulator
A4G23_RS22135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A4G23_RS22140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G23_RS22145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4G23_RS22150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4G23_RS22165	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G23_RS22170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4G23_RS22185	COG0604	alcohol dehydrogenase
A4G23_RS22185	COG3321	synthase
A4G23_RS22200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G23_RS22210	COG1937	Protein conserved in bacteria
A4G23_RS22220	COG1309	transcriptional regulator
A4G23_RS22295	COG0523	cobalamin synthesis protein
A4G23_RS22300	COG2268	Band 7 protein
A4G23_RS22315	COG0142	geranyltranstransferase activity
A4G23_RS22325	COG2124	cytochrome p450
A4G23_RS22330	COG2124	cytochrome p450
A4G23_RS22335	COG0542	response to heat
A4G23_RS22415	COG3903	Transcriptional regulator
A4G23_RS22415	COG3629	intracellular signal transduction
A4G23_RS22435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4G23_RS22445	COG1404	Belongs to the peptidase S8 family
A4G23_RS22460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G23_RS22485	COG0107	imidazoleglycerol-phosphate synthase activity
A4G23_RS22490	COG2197	response regulator
A4G23_RS22495	COG1522	sequence-specific DNA binding
A4G23_RS22500	COG1834	amidinotransferase
A4G23_RS22505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G23_RS22520	COG2197	response regulator
A4G23_RS22525	COG0596	Alpha beta hydrolase
A4G23_RS22625	COG3591	Belongs to the peptidase S1B family
A4G23_RS22625	COG1864	DNA RNA non-specific endonuclease
A4G23_RS22655	COG1799	cell septum assembly
A4G23_RS22695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4G23_RS22755	COG2235	arginine
A4G23_RS22760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4G23_RS22790	COG2072	flavoprotein involved in K transport
A4G23_RS22795	COG0798	PFAM Bile acid sodium symporter
A4G23_RS22805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4G23_RS22810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G23_RS22815	COG1518	maintenance of DNA repeat elements
A4G23_RS22830	COG1857	crispr-associated protein
A4G23_RS22845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4G23_RS22850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4G23_RS22855	COG1653	transport
A4G23_RS22860	COG1175	transmembrane transport
A4G23_RS22865	COG0395	ABC-type sugar transport system, permease component
A4G23_RS22870	COG1940	carbohydrate kinase activity
A4G23_RS22875	COG4213	ABC transporter substrate-binding protein
A4G23_RS22885	COG4214	carbohydrate transport
A4G23_RS22890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4G23_RS22895	COG0531	amino acid
A4G23_RS22905	COG0514	ATP-dependent DNA helicase (RecQ)
A4G23_RS22910	COG1024	Enoyl-CoA hydratase
A4G23_RS22910	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4G23_RS22915	COG0183	Belongs to the thiolase family
A4G23_RS22930	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4G23_RS22945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4G23_RS22960	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4G23_RS22970	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4G23_RS22975	COG3253	May function as heme-dependent peroxidase
A4G23_RS22980	COG3220	belongs to the UPF0276 family
A4G23_RS23040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4G23_RS23045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4G23_RS23070	COG1716	ATPase activity
A4G23_RS23110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4G23_RS23140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G23_RS23155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4G23_RS23180	COG0529	Catalyzes the synthesis of activated sulfate
A4G23_RS23185	COG0175	sulfate reduction
A4G23_RS23215	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS23235	COG0475	glutathione-regulated potassium exporter activity
A4G23_RS23245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4G23_RS23250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4G23_RS23255	COG0019	diaminopimelate decarboxylase activity
A4G23_RS23260	COG1162	GTPase activity
A4G23_RS23265	COG1136	(ABC) transporter
A4G23_RS23265	COG0577	efflux transmembrane transporter activity
A4G23_RS23280	COG1136	(ABC) transporter
A4G23_RS23280	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G23_RS23305	COG0028	Belongs to the TPP enzyme family
A4G23_RS23350	COG0778	Nitroreductase
A4G23_RS23355	COG0135	phosphoribosylanthranilate isomerase activity
A4G23_RS23360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4G23_RS23365	COG0697	spore germination
A4G23_RS23380	COG2313	pseudouridylate synthase activity
A4G23_RS23385	COG1902	pentaerythritol trinitrate reductase activity
A4G23_RS23390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4G23_RS23410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G23_RS23415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G23_RS23445	COG1132	(ABC) transporter
A4G23_RS23450	COG1132	(ABC) transporter
A4G23_RS23460	COG3608	succinylglutamate desuccinylase aspartoacylase
A4G23_RS23460	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4G23_RS23470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4G23_RS23475	COG3237	CsbD-like
A4G23_RS23485	COG2080	2 iron, 2 sulfur cluster binding
A4G23_RS23490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4G23_RS23495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4G23_RS23500	COG2066	Belongs to the glutaminase family
A4G23_RS23505	COG2409	Drug exporters of the RND superfamily
A4G23_RS23510	COG1846	Transcriptional regulator
A4G23_RS23515	COG0702	epimerase
A4G23_RS23530	COG1120	ATPase activity
A4G23_RS23585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G23_RS23620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G23_RS23620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G23_RS23630	COG2197	response regulator
A4G23_RS23635	COG3851	Histidine kinase
A4G23_RS23655	COG0531	amino acid
A4G23_RS23660	COG0586	Pfam SNARE associated Golgi protein
A4G23_RS23680	COG2181	nitrate reductase activity
A4G23_RS23690	COG1140	nitrate reductase beta subunit
A4G23_RS23710	COG2985	domain, Protein
A4G23_RS23710	COG0490	domain, Protein
A4G23_RS23715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4G23_RS23730	COG0617	tRNA 3'-terminal CCA addition
A4G23_RS23730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4G23_RS23730	COG0517	IMP dehydrogenase activity
A4G23_RS23735	COG0589	response to stress
A4G23_RS23750	COG1140	nitrate reductase beta subunit
A4G23_RS23770	COG0477	Major facilitator Superfamily
A4G23_RS23795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4G23_RS23805	COG3118	belongs to the thioredoxin family
A4G23_RS23815	COG0492	ferredoxin-NADP+ reductase activity
A4G23_RS23820	COG2197	response regulator
A4G23_RS23825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4G23_RS23830	COG0318	PFAM AMP-dependent synthetase and ligase
A4G23_RS23880	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
A4G23_RS23885	COG2197	response regulator
A4G23_RS23900	COG1136	(ABC) transporter
A4G23_RS23905	COG1414	Transcriptional regulator
A4G23_RS23920	COG4585	Histidine kinase
A4G23_RS23925	COG2197	response regulator
A4G23_RS23945	COG4214	carbohydrate transport
A4G23_RS23950	COG1129	ABC transporter
A4G23_RS23955	COG1940	carbohydrate kinase activity
A4G23_RS23970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS23990	COG0475	glutathione-regulated potassium exporter activity
A4G23_RS24015	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS24025	COG0300	oxidoreductase activity
A4G23_RS24040	COG3629	intracellular signal transduction
A4G23_RS24040	COG3903	Transcriptional regulator
A4G23_RS24045	COG0477	Major facilitator Superfamily
A4G23_RS24050	COG0583	DNA-binding transcription factor activity
A4G23_RS24055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4G23_RS24095	COG0405	Gamma-glutamyltransferase
A4G23_RS24105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G23_RS24110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4G23_RS24120	COG0659	secondary active sulfate transmembrane transporter activity
A4G23_RS24135	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4G23_RS24160	COG0483	inositol monophosphate 1-phosphatase activity
A4G23_RS24170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4G23_RS24175	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4G23_RS24180	COG0640	Transcriptional regulator
A4G23_RS24185	COG2072	flavoprotein involved in K transport
A4G23_RS24195	COG1556	Lactate utilization protein
A4G23_RS24200	COG1139	Iron-sulfur cluster binding protein
A4G23_RS24205	COG0247	lactate metabolic process
A4G23_RS24225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4G23_RS24230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4G23_RS24245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4G23_RS24250	COG1929	Belongs to the glycerate kinase type-1 family
A4G23_RS24265	COG0688	phosphatidylethanolamine metabolic process
A4G23_RS24270	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS24280	COG2301	Belongs to the HpcH HpaI aldolase family
A4G23_RS24285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS24285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4G23_RS24300	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4G23_RS24315	COG0251	oxidation-reduction process
A4G23_RS24350	COG1522	sequence-specific DNA binding
A4G23_RS24355	COG2362	D-Aminopeptidase
A4G23_RS24360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G23_RS24370	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4G23_RS24375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4G23_RS24385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4G23_RS24410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4G23_RS24425	COG0693	protein deglycase activity
A4G23_RS24440	COG1191	sigma factor activity
A4G23_RS24485	COG0531	amino acid
A4G23_RS24490	COG0583	DNA-binding transcription factor activity
A4G23_RS24495	COG0156	8-amino-7-oxononanoate synthase activity
A4G23_RS24500	COG1063	alcohol dehydrogenase
A4G23_RS24515	COG2154	pterin-4-alpha-carbinolamine dehydratase
A4G23_RS24525	COG4977	sequence-specific DNA binding
A4G23_RS24535	COG2304	oxidoreductase activity
A4G23_RS24560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4G23_RS24565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G23_RS24635	COG2040	homocysteine
A4G23_RS24675	COG3012	SEC-C Motif Domain Protein
A4G23_RS24685	COG1793	dna ligase
A4G23_RS24710	COG0488	(ABC) transporter
A4G23_RS24725	COG1515	deoxyribonuclease V activity
A4G23_RS24730	COG3268	Saccharopine dehydrogenase
A4G23_RS24735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4G23_RS24740	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS24745	COG0183	Belongs to the thiolase family
A4G23_RS24750	COG1024	Enoyl-CoA hydratase
A4G23_RS24750	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4G23_RS24800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G23_RS24805	COG0488	(ABC) transporter
A4G23_RS24815	COG2183	response to ionizing radiation
A4G23_RS24825	COG1024	Enoyl-CoA hydratase
A4G23_RS24840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4G23_RS24885	COG1134	teichoic acid transport
A4G23_RS24890	COG1562	ergosterol biosynthetic process
A4G23_RS24900	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4G23_RS24910	COG1657	PFAM Prenyltransferase squalene oxidase
A4G23_RS24935	COG2365	Tyrosine phosphatase family
A4G23_RS24945	COG2755	lipolytic protein G-D-S-L family
A4G23_RS24960	COG0569	domain protein
A4G23_RS24970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4G23_RS24975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4G23_RS24980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4G23_RS25010	COG1863	multisubunit Na H antiporter MnhE subunit
A4G23_RS25015	COG0651	ATP synthesis coupled electron transport
A4G23_RS25020	COG1006	Multisubunit Na H antiporter MnhC subunit
A4G23_RS25025	COG2111	Na H antiporter
A4G23_RS25025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4G23_RS25045	COG0783	Belongs to the Dps family
A4G23_RS25065	COG1595	DNA-templated transcription, initiation
A4G23_RS25090	COG2226	methyltransferase
A4G23_RS25095	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4G23_RS25095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G23_RS25115	COG0142	geranyltranstransferase activity
A4G23_RS25155	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS25175	COG1881	PFAM PEBP family protein
A4G23_RS25180	COG2207	Transcriptional regulator
A4G23_RS25195	COG0501	Belongs to the peptidase M48B family
A4G23_RS25205	COG0477	Major facilitator Superfamily
A4G23_RS25225	COG0443	Heat shock 70 kDa protein
A4G23_RS25245	COG3189	MarR family transcriptional regulator
A4G23_RS25300	COG0406	alpha-ribazole phosphatase activity
A4G23_RS25315	COG1132	(ABC) transporter
A4G23_RS25320	COG1132	(ABC) transporter
A4G23_RS25365	COG3903	Transcriptional regulator
A4G23_RS25365	COG3629	intracellular signal transduction
A4G23_RS25385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4G23_RS25390	COG1032	radical SAM domain protein
A4G23_RS25450	COG1063	alcohol dehydrogenase
A4G23_RS25465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4G23_RS25475	COG0477	Major facilitator Superfamily
A4G23_RS25495	COG3383	formate dehydrogenase (NAD+) activity
A4G23_RS25505	COG1063	alcohol dehydrogenase
A4G23_RS25515	COG0045	succinate-CoA ligase (ADP-forming) activity
A4G23_RS25515	COG1042	CoA-binding domain protein
A4G23_RS25515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4G23_RS25540	COG0589	response to stress
A4G23_RS25555	COG0516	GMP reductase activity
A4G23_RS25555	COG0517	IMP dehydrogenase activity
A4G23_RS25570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4G23_RS25575	COG1120	ATPase activity
A4G23_RS25625	COG0366	Alpha amylase catalytic
A4G23_RS25625	COG1874	Beta-galactosidase
A4G23_RS25680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4G23_RS25690	COG1652	LysM domain
A4G23_RS25725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4G23_RS25740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G23_RS25745	COG3275	phosphorelay sensor kinase activity
A4G23_RS25750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4G23_RS25810	COG2770	Histidine kinase
A4G23_RS25810	COG2208	phosphoserine phosphatase activity
A4G23_RS25830	COG0583	DNA-binding transcription factor activity
A4G23_RS25840	COG1053	succinate dehydrogenase
A4G23_RS25845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4G23_RS25850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G23_RS25860	COG3360	Dodecin
A4G23_RS25865	COG2182	Extracellular solute-binding protein
A4G23_RS25880	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A4G23_RS25885	COG0121	glutamine amidotransferase
A4G23_RS25890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4G23_RS25895	COG3572	ergothioneine biosynthetic process
A4G23_RS25910	COG0183	Belongs to the thiolase family
A4G23_RS25915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G23_RS25925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4G23_RS25995	COG2207	Transcriptional regulator
A4G23_RS25995	COG3708	Transcriptional regulator
A4G23_RS26005	COG0367	asparagine synthase
A4G23_RS26010	COG2814	Major facilitator Superfamily
A4G23_RS26045	COG2124	cytochrome p450
A4G23_RS26060	COG1357	PFAM Pentapeptide repeats (8 copies)
A4G23_RS26100	COG3458	cephalosporin-C deacetylase activity
A4G23_RS26125	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS26130	COG1960	acyl-CoA dehydrogenase activity
A4G23_RS26140	COG0601	transmembrane transport
A4G23_RS26145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G23_RS26170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G23_RS26220	COG1597	lipid kinase activity
A4G23_RS26235	COG0243	molybdopterin cofactor binding
A4G23_RS26255	COG0659	secondary active sulfate transmembrane transporter activity
A4G23_RS26325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4G23_RS26330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS26360	COG2890	protein-(glutamine-N5) methyltransferase activity
A4G23_RS26385	COG0189	ligase activity
A4G23_RS26395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4G23_RS26400	COG1396	sequence-specific DNA binding
A4G23_RS26405	COG0235	Class ii aldolase
A4G23_RS26410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G23_RS26420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4G23_RS26435	COG3629	intracellular signal transduction
A4G23_RS26560	COG2318	DinB family
A4G23_RS26570	COG1028	Short-chain dehydrogenase reductase Sdr
A4G23_RS26590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G23_RS26590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G23_RS26605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G23_RS26610	COG1937	Protein conserved in bacteria
A4G23_RS26665	COG0515	serine threonine protein kinase
A4G23_RS26675	COG1733	regulation of RNA biosynthetic process
A4G23_RS26705	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
A4G23_RS26730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4G23_RS26735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4G23_RS26740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4G23_RS26815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4G23_RS26825	COG1012	belongs to the aldehyde dehydrogenase family
A4G23_RS26835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4G23_RS26845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4G23_RS26865	COG2018	Roadblock/LC7 domain
A4G23_RS26880	COG1793	dna ligase
A4G23_RS26915	COG0745	RESPONSE REGULATOR receiver
A4G23_RS26945	COG2124	cytochrome p450
A4G23_RS26950	COG3424	synthase
A4G23_RS26960	COG0726	polysaccharide deacetylase
A4G23_RS26975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4G23_RS26995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G23_RS27010	COG1595	DNA-templated transcription, initiation
A4G23_RS27020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4G23_RS27035	COG3340	Belongs to the peptidase S51 family
A4G23_RS27050	COG0656	L-ascorbic acid biosynthetic process
A4G23_RS27055	COG2706	6-phosphogluconolactonase activity
A4G23_RS27075	COG0009	L-threonylcarbamoyladenylate synthase
A4G23_RS27120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4G23_RS27120	COG1017	nitric oxide dioxygenase activity
A4G23_RS27160	COG1309	transcriptional regulator
A4G23_RS27180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G23_RS27200	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G23_RS27230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G23_RS27235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4G23_RS27245	COG0066	3-isopropylmalate dehydratase activity
A4G23_RS27250	COG0436	Aminotransferase
A4G23_RS27260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4G23_RS27265	COG2197	response regulator
A4G23_RS27275	COG2267	carboxylic ester hydrolase activity
A4G23_RS27300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4G23_RS27315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G23_RS27330	COG0420	3'-5' exonuclease activity
A4G23_RS27335	COG0419	ATPase involved in DNA repair