locus-tag	class	description
F0345_RS00050	COG2197	response regulator
F0345_RS00055	COG4585	Histidine kinase
F0345_RS00070	COG1131	(ABC) transporter
F0345_RS00120	COG0791	NLP P60 protein
F0345_RS00120	COG1388	LysM domain
F0345_RS00120	COG3103	Sh3 type 3 domain protein
F0345_RS00185	COG3800	Transcriptional regulator
F0345_RS00185	COG1396	sequence-specific DNA binding
F0345_RS00215	COG1509	lysine 2,3-aminomutase activity
F0345_RS00355	COG1349	DNA-binding transcription factor activity
F0345_RS00360	COG0673	inositol 2-dehydrogenase activity
F0345_RS00400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0345_RS00415	COG1937	Protein conserved in bacteria
F0345_RS00480	COG2197	response regulator
F0345_RS00485	COG4585	Histidine kinase
F0345_RS00495	COG0028	Belongs to the TPP enzyme family
F0345_RS00500	COG0277	FAD linked oxidase domain protein
F0345_RS00500	COG0247	lactate metabolic process
F0345_RS00505	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS00510	COG0243	molybdopterin cofactor binding
F0345_RS00540	COG0444	Belongs to the ABC transporter superfamily
F0345_RS00545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS00550	COG0601	transmembrane transport
F0345_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS00575	COG1309	transcriptional regulator
F0345_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS00615	COG0183	Belongs to the thiolase family
F0345_RS00620	COG1309	transcriptional regulator
F0345_RS00630	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00635	COG1024	Enoyl-CoA hydratase
F0345_RS00640	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00645	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00650	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00665	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00670	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS00685	COG1309	transcriptional regulator
F0345_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS00695	COG3971	2-oxopent-4-enoate hydratase activity
F0345_RS00705	COG0183	Belongs to the thiolase family
F0345_RS00715	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00720	COG2030	dehydratase
F0345_RS00725	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00730	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS00750	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00755	COG0183	Belongs to the thiolase family
F0345_RS00775	COG1053	succinate dehydrogenase
F0345_RS00780	COG0346	lactoylglutathione lyase activity
F0345_RS00805	COG1053	succinate dehydrogenase
F0345_RS00815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F0345_RS00825	COG0798	PFAM Bile acid sodium symporter
F0345_RS00850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0345_RS00855	COG1937	Protein conserved in bacteria
F0345_RS00870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0345_RS00870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0345_RS00880	COG2409	Drug exporters of the RND superfamily
F0345_RS00895	COG3119	arylsulfatase activity
F0345_RS00900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0345_RS00940	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS00950	COG1960	acyl-CoA dehydrogenase activity
F0345_RS00960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0345_RS00990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0345_RS00990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0345_RS00995	COG1063	alcohol dehydrogenase
F0345_RS01000	COG0477	Major facilitator Superfamily
F0345_RS01005	COG0492	ferredoxin-NADP+ reductase activity
F0345_RS01035	COG0656	L-ascorbic acid biosynthetic process
F0345_RS01040	COG2197	response regulator
F0345_RS01045	COG4585	Histidine kinase
F0345_RS01050	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
F0345_RS01130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0345_RS01130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0345_RS01155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0345_RS01160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F0345_RS01165	COG2080	2 iron, 2 sulfur cluster binding
F0345_RS01190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0345_RS01200	COG0604	alcohol dehydrogenase
F0345_RS01215	COG3396	Phenylacetate-CoA oxygenase
F0345_RS01225	COG3396	Phenylacetate-CoA oxygenase
F0345_RS01230	COG2151	metal-sulfur cluster biosynthetic enzyme
F0345_RS01235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0345_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS01245	COG3483	tryptophan 2,3-dioxygenase activity
F0345_RS01275	COG1129	ABC transporter
F0345_RS01285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0345_RS01320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0345_RS01325	COG2124	cytochrome p450
F0345_RS01330	COG3959	Transketolase, thiamine diphosphate binding domain
F0345_RS01345	COG0604	alcohol dehydrogenase
F0345_RS01345	COG3321	synthase
F0345_RS01360	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS01365	COG3321	synthase
F0345_RS01365	COG0604	alcohol dehydrogenase
F0345_RS01380	COG3321	synthase
F0345_RS01380	COG0604	alcohol dehydrogenase
F0345_RS01395	COG1595	DNA-templated transcription, initiation
F0345_RS01405	COG1131	(ABC) transporter
F0345_RS01455	COG0142	geranyltranstransferase activity
F0345_RS01490	COG2318	DinB family
F0345_RS01500	COG1124	(ABC) transporter
F0345_RS01505	COG0444	Belongs to the ABC transporter superfamily
F0345_RS01510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS01525	COG1960	acyl-CoA dehydrogenase activity
F0345_RS01530	COG1960	acyl-CoA dehydrogenase activity
F0345_RS01555	COG0517	IMP dehydrogenase activity
F0345_RS01555	COG1125	glycine betaine transport
F0345_RS01565	COG1174	glycine betaine transport
F0345_RS01570	COG1174	glycine betaine transport
F0345_RS01600	COG2828	Protein conserved in bacteria
F0345_RS01605	COG2159	amidohydrolase
F0345_RS01620	COG2814	Major facilitator Superfamily
F0345_RS01620	COG0477	Major facilitator Superfamily
F0345_RS01655	COG0110	maltose O-acetyltransferase activity
F0345_RS01660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0345_RS01665	COG1984	allophanate hydrolase subunit 2
F0345_RS01670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F0345_RS01675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F0345_RS01715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0345_RS01720	COG0300	oxidoreductase activity
F0345_RS01725	COG2201	protein-glutamate methylesterase activity
F0345_RS01750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0345_RS01755	COG0590	tRNA wobble adenosine to inosine editing
F0345_RS01760	COG0363	glucosamine-6-phosphate deaminase activity
F0345_RS01765	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F0345_RS01775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0345_RS01785	COG3458	cephalosporin-C deacetylase activity
F0345_RS01795	COG0747	negative chemotaxis
F0345_RS01805	COG0444	Belongs to the ABC transporter superfamily
F0345_RS01825	COG4257	antibiotic catabolic process
F0345_RS01845	COG3268	Saccharopine dehydrogenase
F0345_RS01855	COG2188	Transcriptional regulator
F0345_RS01870	COG1175	transmembrane transport
F0345_RS01875	COG0395	ABC-type sugar transport system, permease component
F0345_RS01880	COG4948	Mandelate Racemase Muconate Lactonizing
F0345_RS01885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F0345_RS01940	COG2124	cytochrome p450
F0345_RS01960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0345_RS01965	COG0254	rRNA binding
F0345_RS01975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0345_RS01985	COG2310	stress, protein
F0345_RS01995	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F0345_RS02015	COG0142	geranyltranstransferase activity
F0345_RS02020	COG1796	DNA polymerase
F0345_RS02020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0345_RS02030	COG2837	iron assimilation
F0345_RS02060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0345_RS02065	COG4221	oxidoreductase activity
F0345_RS02090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0345_RS02095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0345_RS02115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0345_RS02120	COG0121	glutamine amidotransferase
F0345_RS02125	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F0345_RS02130	COG2182	Extracellular solute-binding protein
F0345_RS02135	COG3360	Dodecin
F0345_RS02145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0345_RS02150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0345_RS02155	COG1053	succinate dehydrogenase
F0345_RS02165	COG0583	DNA-binding transcription factor activity
F0345_RS02200	COG0726	polysaccharide deacetylase
F0345_RS02220	COG3275	phosphorelay sensor kinase activity
F0345_RS02225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0345_RS02235	COG3279	Response regulator of the LytR AlgR family
F0345_RS02240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0345_RS02275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0345_RS02290	COG1132	(ABC) transporter
F0345_RS02305	COG0656	L-ascorbic acid biosynthetic process
F0345_RS02325	COG0784	Response regulator, receiver
F0345_RS02330	COG4251	negative regulation of phosphorylation
F0345_RS02370	COG0501	Belongs to the peptidase M48B family
F0345_RS02375	COG2723	6-phospho-beta-galactosidase activity
F0345_RS02400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0345_RS02420	COG1960	acyl-CoA dehydrogenase activity
F0345_RS02430	COG0242	peptide deformylase activity
F0345_RS02440	COG3442	glutamine amidotransferase
F0345_RS02445	COG0205	6-phosphofructokinase activity
F0345_RS02460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0345_RS02460	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0345_RS02465	COG0435	Glutathione S-transferase
F0345_RS02475	COG2175	clavaminate synthase activity
F0345_RS02520	COG0204	Acyl-transferase
F0345_RS02525	COG4552	Acetyltransferase involved in intracellular survival and related
F0345_RS02530	COG0791	NLP P60 protein
F0345_RS02555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0345_RS02560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F0345_RS02565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0345_RS02585	COG0456	acetyltransferase
F0345_RS02615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0345_RS02620	COG3663	DNA glycosylase
F0345_RS02630	COG1940	carbohydrate kinase activity
F0345_RS02635	COG2188	Transcriptional regulator
F0345_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS02675	COG1522	sequence-specific DNA binding
F0345_RS02680	COG0419	ATPase involved in DNA repair
F0345_RS02685	COG0420	3'-5' exonuclease activity
F0345_RS02700	COG1739	Uncharacterized protein family UPF0029
F0345_RS02705	COG1832	CoA-binding protein
F0345_RS02710	COG0110	maltose O-acetyltransferase activity
F0345_RS02755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0345_RS02775	COG1968	undecaprenyl-diphosphatase activity
F0345_RS02785	COG1982	Orn Lys Arg decarboxylase major
F0345_RS02805	COG0673	inositol 2-dehydrogenase activity
F0345_RS02830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0345_RS02865	COG0154	amidase activity
F0345_RS02880	COG0697	spore germination
F0345_RS02895	COG0697	spore germination
F0345_RS02945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0345_RS02945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0345_RS02955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0345_RS02995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F0345_RS03020	COG2190	(PTS) system
F0345_RS03025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0345_RS03035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0345_RS03050	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F0345_RS03120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0345_RS03125	COG2364	Membrane
F0345_RS03135	COG2270	Major facilitator Superfamily
F0345_RS03145	COG3030	protein affecting phage T7 exclusion by the F plasmid
F0345_RS03150	COG0463	Glycosyl transferase, family 2
F0345_RS03170	COG1960	acyl-CoA dehydrogenase activity
F0345_RS03200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0345_RS03205	COG0140	phosphoribosyl-ATP diphosphatase activity
F0345_RS03210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0345_RS03215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0345_RS03215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0345_RS03220	COG3201	nicotinamide mononucleotide transporter
F0345_RS03235	COG1090	epimerase
F0345_RS03240	COG1846	Transcriptional regulator
F0345_RS03240	COG1940	carbohydrate kinase activity
F0345_RS03245	COG0738	Major facilitator superfamily
F0345_RS03255	COG2233	PERMEase
F0345_RS03260	COG0697	spore germination
F0345_RS03265	COG0583	DNA-binding transcription factor activity
F0345_RS03280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0345_RS03320	COG2390	Transcriptional regulator
F0345_RS03325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0345_RS03330	COG2318	DinB family
F0345_RS03345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0345_RS03390	COG1758	RNA polymerase activity
F0345_RS03405	COG0284	orotidine-5'-phosphate decarboxylase activity
F0345_RS03410	COG0167	dihydroorotate dehydrogenase activity
F0345_RS03415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0345_RS03420	COG0505	Belongs to the CarA family
F0345_RS03430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0345_RS03435	COG0540	Belongs to the ATCase OTCase family
F0345_RS03440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F0345_RS03450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0345_RS03455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0345_RS03460	COG0006	proline dipeptidase activity
F0345_RS03470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0345_RS03475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0345_RS03480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0345_RS03485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0345_RS03490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0345_RS03495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0345_RS03515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0345_RS03530	COG0124	histidyl-tRNA synthetase
F0345_RS03540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0345_RS03545	COG1196	nuclear chromosome segregation
F0345_RS03555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0345_RS03560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0345_RS03565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0345_RS03570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0345_RS03580	COG2255	four-way junction helicase activity
F0345_RS03585	COG0632	four-way junction helicase activity
F0345_RS03590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0345_RS03595	COG0217	transcriptional regulatory protein
F0345_RS03600	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F0345_RS03605	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F0345_RS03615	COG0438	transferase activity, transferring glycosyl groups
F0345_RS03620	COG1560	Kdo2-lipid A biosynthetic process
F0345_RS03625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0345_RS03640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0345_RS03645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0345_RS03780	COG1648	precorrin-2 dehydrogenase activity
F0345_RS03780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0345_RS03785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0345_RS03800	COG1464	Belongs to the NlpA lipoprotein family
F0345_RS03805	COG1464	Belongs to the NlpA lipoprotein family
F0345_RS03810	COG2011	ABC-type metal ion transport system permease component
F0345_RS03815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0345_RS03820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0345_RS03845	COG0584	glycerophosphoryl diester phosphodiesterase
F0345_RS03850	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS03850	COG0204	Acyl-transferase
F0345_RS03855	COG0477	Major facilitator Superfamily
F0345_RS03870	COG0165	Argininosuccinate lyase
F0345_RS03880	COG0385	Bile acid
F0345_RS03885	COG2409	Drug exporters of the RND superfamily
F0345_RS03895	COG2197	response regulator
F0345_RS03900	COG4585	Histidine kinase
F0345_RS03905	COG1438	arginine binding
F0345_RS03910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0345_RS03915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0345_RS03920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F0345_RS03925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0345_RS03985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0345_RS03990	COG0697	spore germination
F0345_RS04020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0345_RS04020	COG0072	phenylalanine-tRNA ligase activity
F0345_RS04025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0345_RS04030	COG5002	protein histidine kinase activity
F0345_RS04040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0345_RS04045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0345_RS04050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0345_RS04055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F0345_RS04065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0345_RS04100	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS04105	COG0174	glutamine synthetase
F0345_RS04120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F0345_RS04145	COG4175	Glycine betaine
F0345_RS04145	COG0517	IMP dehydrogenase activity
F0345_RS04150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0345_RS04160	COG1595	DNA-templated transcription, initiation
F0345_RS04170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F0345_RS04180	COG0564	pseudouridine synthase activity
F0345_RS04210	COG2124	cytochrome p450
F0345_RS04225	COG0805	protein transport
F0345_RS04230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0345_RS04265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F0345_RS04275	COG1609	Transcriptional regulator
F0345_RS04280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F0345_RS04285	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F0345_RS04295	COG4122	O-methyltransferase activity
F0345_RS04300	COG1222	aaa ATPase
F0345_RS04320	COG1994	Peptidase M50
F0345_RS04320	COG0517	IMP dehydrogenase activity
F0345_RS04330	COG2197	response regulator
F0345_RS04335	COG0747	negative chemotaxis
F0345_RS04345	COG0646	methionine synthase
F0345_RS04345	COG1410	methionine synthase
F0345_RS04355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0345_RS04360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0345_RS04365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0345_RS04375	COG0215	cysteine-tRNA ligase activity
F0345_RS04395	COG0598	Magnesium transport protein CorA
F0345_RS04405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0345_RS04410	COG0667	Aldo Keto reductase
F0345_RS04445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0345_RS04455	COG3012	SEC-C Motif Domain Protein
F0345_RS04465	COG3265	gluconokinase activity
F0345_RS04485	COG3573	Dehydrogenase
F0345_RS04500	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F0345_RS04505	COG2149	membrane
F0345_RS04525	COG1960	acyl-CoA dehydrogenase activity
F0345_RS04535	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS04550	COG0488	(ABC) transporter
F0345_RS04560	COG3876	Protein conserved in bacteria
F0345_RS04605	COG1309	transcriptional regulator
F0345_RS04610	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F0345_RS04615	COG2188	Transcriptional regulator
F0345_RS04620	COG3973	AAA domain
F0345_RS04635	COG2755	lipolytic protein G-D-S-L family
F0345_RS04655	COG1216	Glycosyl transferase, family 2
F0345_RS04660	COG0726	polysaccharide deacetylase
F0345_RS04715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0345_RS04720	COG0587	DNA-directed DNA polymerase activity
F0345_RS04735	COG0330	HflC and HflK could
F0345_RS04755	COG1799	cell septum assembly
F0345_RS04760	COG0477	Major facilitator Superfamily
F0345_RS04770	COG0671	phosphoesterase, PA-phosphatase related
F0345_RS04790	COG0438	transferase activity, transferring glycosyl groups
F0345_RS04810	COG1160	GTP binding
F0345_RS04820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0345_RS04830	COG1397	ADP-ribosylglycohydrolase
F0345_RS04840	COG1187	pseudouridine synthase activity
F0345_RS04845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F0345_RS04850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F0345_RS04865	COG0686	Belongs to the AlaDH PNT family
F0345_RS04875	COG0494	nUDIX hydrolase
F0345_RS04880	COG0504	CTP synthase activity
F0345_RS04885	COG3387	PFAM Glycoside hydrolase 15-related
F0345_RS04895	COG0297	glycogen (starch) synthase activity
F0345_RS04905	COG0497	DNA recombination
F0345_RS04910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0345_RS04930	COG0647	UMP catabolic process
F0345_RS04965	COG2094	Belongs to the DNA glycosylase MPG family
F0345_RS04975	COG1881	PFAM PEBP family protein
F0345_RS04995	COG1119	ATPase activity
F0345_RS05010	COG2197	response regulator
F0345_RS05035	COG0842	Transport permease protein
F0345_RS05035	COG1131	(ABC) transporter
F0345_RS05035	COG1716	ATPase activity
F0345_RS05040	COG0560	Phosphoserine phosphatase
F0345_RS05040	COG3830	Belongs to the UPF0237 family
F0345_RS05055	COG2807	transmembrane transport
F0345_RS05060	COG2186	Transcriptional regulator
F0345_RS05070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0345_RS05080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0345_RS05085	COG2261	transglycosylase associated protein
F0345_RS05100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0345_RS05105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0345_RS05120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0345_RS05140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0345_RS05185	COG1024	Enoyl-CoA hydratase
F0345_RS05195	COG0488	(ABC) transporter
F0345_RS05210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0345_RS05220	COG0235	Class ii aldolase
F0345_RS05235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F0345_RS05240	COG1492	cobalamin metabolic process
F0345_RS05255	COG1797	cobyrinic acid a,c-diamide synthase activity
F0345_RS05285	COG0456	acetyltransferase
F0345_RS05295	COG1917	Cupin 2, conserved barrel domain protein
F0345_RS05300	COG5285	phytanoyl-CoA dioxygenase
F0345_RS05325	COG4585	Histidine kinase
F0345_RS05360	COG2171	N-acyltransferase activity
F0345_RS05370	COG0822	iron-sulfur transferase activity
F0345_RS05375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0345_RS05380	COG0396	ATPase activity
F0345_RS05390	COG0719	Fe-S assembly protein
F0345_RS05405	COG1131	(ABC) transporter
F0345_RS05415	COG1612	heme a metabolic process
F0345_RS05425	COG0109	protoheme IX farnesyltransferase activity
F0345_RS05430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0345_RS05435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0345_RS05450	COG0363	glucosamine-6-phosphate deaminase activity
F0345_RS05455	COG0166	Belongs to the GPI family
F0345_RS05465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0345_RS05470	COG0149	triose-phosphate isomerase activity
F0345_RS05475	COG0126	phosphoglycerate kinase activity
F0345_RS05480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0345_RS05485	COG1481	regulation of sporulation
F0345_RS05495	COG1660	Displays ATPase and GTPase activities
F0345_RS05515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0345_RS05530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0345_RS05550	COG0556	nucleotide-excision repair
F0345_RS05560	COG0584	glycerophosphoryl diester phosphodiesterase
F0345_RS05570	COG0477	Major facilitator Superfamily
F0345_RS05615	COG1288	antiporter activity
F0345_RS05640	COG0237	dephospho-CoA kinase activity
F0345_RS05655	COG2226	methyltransferase
F0345_RS05660	COG1643	Atp-dependent helicase
F0345_RS05680	COG2050	protein possibly involved in aromatic compounds catabolism
F0345_RS05695	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0345_RS05735	COG0737	Belongs to the 5'-nucleotidase family
F0345_RS05740	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F0345_RS05770	COG0287	Prephenate dehydrogenase
F0345_RS05770	COG1605	Chorismate mutase
F0345_RS05780	COG0513	Belongs to the DEAD box helicase family
F0345_RS05785	COG1278	Cold shock
F0345_RS05800	COG0067	glutamate synthase
F0345_RS05800	COG0070	glutamate synthase
F0345_RS05800	COG0069	glutamate synthase activity
F0345_RS05810	COG1397	ADP-ribosylglycohydrolase
F0345_RS05835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0345_RS05845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0345_RS05855	COG0159	tryptophan synthase activity
F0345_RS05860	COG0133	tryptophan synthase activity
F0345_RS05865	COG0134	indole-3-glycerol-phosphate synthase activity
F0345_RS05895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0345_RS05915	COG0107	imidazoleglycerol-phosphate synthase activity
F0345_RS05925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0345_RS05930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0345_RS05940	COG0131	Imidazoleglycerol-phosphate dehydratase
F0345_RS05945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0345_RS05950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0345_RS05965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0345_RS05970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0345_RS05990	COG1432	Conserved Protein
F0345_RS06000	COG0587	DNA-directed DNA polymerase activity
F0345_RS06020	COG0515	serine threonine protein kinase
F0345_RS06035	COG2153	protein acetylation
F0345_RS06045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0345_RS06055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0345_RS06060	COG3599	regulation of cell shape
F0345_RS06070	COG1799	cell septum assembly
F0345_RS06080	COG1496	oxidoreductase activity
F0345_RS06085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0345_RS06090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0345_RS06095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0345_RS06105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F0345_RS06110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0345_RS06120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0345_RS06135	COG0275	rRNA processing
F0345_RS06145	COG0714	Associated with various cellular activities
F0345_RS06165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0345_RS06170	COG1129	ABC transporter
F0345_RS06180	COG1309	transcriptional regulator
F0345_RS06200	COG0352	thiamine-phosphate diphosphorylase activity
F0345_RS06210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0345_RS06215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0345_RS06215	COG2022	thiamine diphosphate biosynthetic process
F0345_RS06225	COG2022	thiamine diphosphate biosynthetic process
F0345_RS06230	COG0515	serine threonine protein kinase
F0345_RS06230	COG2815	serine threonine protein kinase
F0345_RS06235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0345_RS06240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F0345_RS06245	COG2193	ferroxidase activity
F0345_RS06250	COG0243	molybdopterin cofactor binding
F0345_RS06255	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F0345_RS06270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0345_RS06275	COG2197	response regulator
F0345_RS06280	COG4585	Histidine kinase
F0345_RS06305	COG1940	carbohydrate kinase activity
F0345_RS06315	COG0003	Pfam Anion-transporting ATPase
F0345_RS06390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0345_RS06395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0345_RS06400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F0345_RS06405	COG0723	plastoquinol--plastocyanin reductase activity
F0345_RS06410	COG2010	Cytochrome c
F0345_RS06415	COG1845	cytochrome c oxidase, subunit III
F0345_RS06425	COG1376	ErfK ybiS ycfS ynhG family protein
F0345_RS06435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0345_RS06440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F0345_RS06445	COG1104	cysteine desulfurase activity
F0345_RS06450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0345_RS06475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0345_RS06480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0345_RS06485	COG2197	response regulator
F0345_RS06530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0345_RS06540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F0345_RS06545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0345_RS06550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0345_RS06555	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0345_RS06565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0345_RS06615	COG0321	lipoyl(octanoyl) transferase activity
F0345_RS06620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0345_RS06640	COG3415	Transposase
F0345_RS06640	COG2801	Transposase and inactivated derivatives
F0345_RS06665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0345_RS06675	COG2376	Dihydroxyacetone kinase
F0345_RS06680	COG2326	polyphosphate kinase activity
F0345_RS06745	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS06765	COG0745	RESPONSE REGULATOR receiver
F0345_RS06790	COG1309	transcriptional regulator
F0345_RS06810	COG0366	Alpha amylase catalytic
F0345_RS06815	COG0395	ABC-type sugar transport system, permease component
F0345_RS06820	COG1175	transmembrane transport
F0345_RS06825	COG2182	Extracellular solute-binding protein
F0345_RS06830	COG1609	Transcriptional regulator
F0345_RS06845	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0345_RS06885	COG0174	glutamine synthetase
F0345_RS06905	COG2132	Multicopper oxidase
F0345_RS06910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0345_RS06910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0345_RS06920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0345_RS06925	COG1994	Peptidase M50
F0345_RS06975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS06980	COG1120	ATPase activity
F0345_RS07000	COG1834	amidinotransferase
F0345_RS07015	COG2814	Major facilitator Superfamily
F0345_RS07025	COG0076	glutamate decarboxylase activity
F0345_RS07035	COG0300	oxidoreductase activity
F0345_RS07045	COG0384	phenazine biosynthesis protein PhzF
F0345_RS07055	COG2226	methyltransferase
F0345_RS07090	COG0745	RESPONSE REGULATOR receiver
F0345_RS07115	COG3022	response to hydroperoxide
F0345_RS07120	COG0800	Aldolase
F0345_RS07135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0345_RS07150	COG1131	(ABC) transporter
F0345_RS07160	COG4585	Histidine kinase
F0345_RS07170	COG2197	response regulator
F0345_RS07185	COG1960	acyl-CoA dehydrogenase activity
F0345_RS07200	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0345_RS07220	COG0438	transferase activity, transferring glycosyl groups
F0345_RS07285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0345_RS07340	COG0586	Pfam SNARE associated Golgi protein
F0345_RS07350	COG1358	cellular component organization or biogenesis
F0345_RS07395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0345_RS07415	COG4585	Histidine kinase
F0345_RS07420	COG2197	response regulator
F0345_RS07440	COG1741	Belongs to the pirin family
F0345_RS07455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0345_RS07460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0345_RS07465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0345_RS07490	COG1764	response to oxidative stress
F0345_RS07495	COG2130	NADP-dependent
F0345_RS07510	COG1077	Cell shape determining protein MreB Mrl
F0345_RS07525	COG2890	protein-(glutamine-N5) methyltransferase activity
F0345_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS07545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0345_RS07570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0345_RS07580	COG3383	formate dehydrogenase (NAD+) activity
F0345_RS07580	COG0243	molybdopterin cofactor binding
F0345_RS07585	COG0437	4 iron, 4 sulfur cluster binding
F0345_RS07600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F0345_RS07610	COG2851	Citrate transporter
F0345_RS07615	COG4565	transcriptional regulatory protein
F0345_RS07620	COG3290	protein histidine kinase activity
F0345_RS07630	COG0358	DNA primase activity
F0345_RS07645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0345_RS07665	COG1070	Carbohydrate kinase
F0345_RS07690	COG2239	Acts as a magnesium transporter
F0345_RS07695	COG0702	epimerase
F0345_RS07705	COG2226	methyltransferase
F0345_RS07715	COG1324	tolerance protein
F0345_RS07730	COG0574	Belongs to the PEP-utilizing enzyme family
F0345_RS07730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0345_RS07735	COG1940	carbohydrate kinase activity
F0345_RS07735	COG1846	Transcriptional regulator
F0345_RS07740	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
F0345_RS07750	COG3467	pyridoxamine 5'-phosphate
F0345_RS07815	COG0423	glycine-tRNA ligase activity
F0345_RS07825	COG1121	(ABC) transporter
F0345_RS07830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0345_RS07840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0345_RS07845	COG1381	Involved in DNA repair and RecF pathway recombination
F0345_RS07855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0345_RS07870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0345_RS07880	COG2315	Protein conserved in bacteria
F0345_RS07890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0345_RS07910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0345_RS07915	COG1486	melibiose metabolic process
F0345_RS07930	COG0604	alcohol dehydrogenase
F0345_RS07940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0345_RS07945	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F0345_RS07965	COG1234	tRNA 3'-trailer cleavage
F0345_RS07970	COG0537	adenosine 5'-monophosphoramidase activity
F0345_RS07975	COG0793	Belongs to the peptidase S41A family
F0345_RS07975	COG4946	Tricorn protease homolog
F0345_RS07990	COG0484	heat shock protein binding
F0345_RS08025	COG0481	GTPase activity
F0345_RS08030	COG0268	Binds directly to 16S ribosomal RNA
F0345_RS08045	COG2353	YceI-like domain
F0345_RS08060	COG1307	EDD domain protein, DegV family
F0345_RS08070	COG0495	leucyl-tRNA aminoacylation
F0345_RS08100	COG0799	negative regulation of ribosome biogenesis
F0345_RS08110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0345_RS08125	COG0501	Belongs to the peptidase M48B family
F0345_RS08140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0345_RS08150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0345_RS08170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0345_RS08175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0345_RS08180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0345_RS08185	COG1530	ribonuclease E activity
F0345_RS08205	COG0772	Belongs to the SEDS family
F0345_RS08225	COG1077	Cell shape determining protein MreB Mrl
F0345_RS08230	COG0105	UTP biosynthetic process
F0345_RS08240	COG0285	dihydrofolate synthase activity
F0345_RS08245	COG0525	valine-tRNA ligase activity
F0345_RS08255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0345_RS08260	COG0740	serine-type endopeptidase activity
F0345_RS08265	COG0740	serine-type endopeptidase activity
F0345_RS08270	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0345_RS08290	COG3594	Acyltransferase
F0345_RS08295	COG0475	glutathione-regulated potassium exporter activity
F0345_RS08305	COG4552	Acetyltransferase involved in intracellular survival and related
F0345_RS08320	COG1113	amino acid transport
F0345_RS08325	COG1268	BioY protein
F0345_RS08330	COG1113	amino acid transport
F0345_RS08335	COG1113	amino acid transport
F0345_RS08340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F0345_RS08345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F0345_RS08370	COG4266	Belongs to the allantoicase family
F0345_RS08430	COG2188	Transcriptional regulator
F0345_RS08440	COG1674	ftsk spoiiie
F0345_RS08455	COG0582	viral genome integration into host DNA
F0345_RS08480	COG0583	DNA-binding transcription factor activity
F0345_RS08515	COG0668	transmembrane transport
F0345_RS08525	COG1486	melibiose metabolic process
F0345_RS08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0345_RS08550	COG0515	serine threonine protein kinase
F0345_RS08570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0345_RS08575	COG2346	COG2346, Truncated hemoglobins
F0345_RS08580	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS08595	COG1136	(ABC) transporter
F0345_RS08690	COG1695	Transcriptional regulator
F0345_RS08745	COG3962	Belongs to the TPP enzyme family
F0345_RS08750	COG3718	enzyme involved in inositol metabolism
F0345_RS08795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0345_RS08800	COG1472	Belongs to the glycosyl hydrolase 3 family
F0345_RS08810	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS08825	COG3960	tartronate-semialdehyde synthase activity
F0345_RS08835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0345_RS08855	COG1946	Acyl-CoA thioesterase
F0345_RS08865	COG1309	transcriptional regulator
F0345_RS08870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0345_RS08885	COG1960	acyl-CoA dehydrogenase activity
F0345_RS08925	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS08945	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F0345_RS08970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0345_RS08985	COG4977	sequence-specific DNA binding
F0345_RS08990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F0345_RS09075	COG0406	alpha-ribazole phosphatase activity
F0345_RS09090	COG0012	GTP binding
F0345_RS09105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0345_RS09110	COG1113	amino acid transport
F0345_RS09115	COG1570	exodeoxyribonuclease VII activity
F0345_RS09120	COG1722	exodeoxyribonuclease VII activity
F0345_RS09125	COG0778	Nitroreductase
F0345_RS09155	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F0345_RS09155	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F0345_RS09170	COG0114	fumarate hydratase activity
F0345_RS09180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0345_RS09190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0345_RS09210	COG1136	(ABC) transporter
F0345_RS09220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0345_RS09225	COG0450	alkyl hydroperoxide reductase
F0345_RS09245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F0345_RS09250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0345_RS09255	COG0667	Aldo Keto reductase
F0345_RS09280	COG2304	oxidoreductase activity
F0345_RS09285	COG0656	L-ascorbic acid biosynthetic process
F0345_RS09290	COG2814	Major facilitator Superfamily
F0345_RS09350	COG2894	cell division
F0345_RS09385	COG0251	oxidation-reduction process
F0345_RS09390	COG1414	Transcriptional regulator
F0345_RS09405	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F0345_RS09435	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F0345_RS09455	COG1331	Highly conserved protein containing a thioredoxin domain
F0345_RS09470	COG3631	Ketosteroid isomerase-related protein
F0345_RS09475	COG0702	epimerase
F0345_RS09500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F0345_RS09510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0345_RS09525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F0345_RS09530	COG2255	four-way junction helicase activity
F0345_RS09555	COG2318	DinB family
F0345_RS09560	COG1064	alcohol dehydrogenase
F0345_RS09575	COG2986	histidine ammonia-lyase
F0345_RS09585	COG1024	Enoyl-CoA hydratase
F0345_RS09590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F0345_RS09600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0345_RS09615	COG0424	maF-like protein
F0345_RS09630	COG4770	biotin carboxylase activity
F0345_RS09670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0345_RS09685	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS09705	COG1595	DNA-templated transcription, initiation
F0345_RS09710	COG0745	RESPONSE REGULATOR receiver
F0345_RS09715	COG2205	protein histidine kinase activity
F0345_RS09740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0345_RS09750	COG0583	DNA-binding transcription factor activity
F0345_RS09755	COG2814	Major facilitator Superfamily
F0345_RS09785	COG1079	Belongs to the binding-protein-dependent transport system permease family
F0345_RS09790	COG4603	Belongs to the binding-protein-dependent transport system permease family
F0345_RS09795	COG3845	ABC transporter
F0345_RS09800	COG1744	ABC transporter substrate-binding protein PnrA-like
F0345_RS09820	COG1473	amidohydrolase
F0345_RS09820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F0345_RS09830	COG2089	acid synthase
F0345_RS09835	COG1083	cytidylyl-transferase
F0345_RS09845	COG1216	Glycosyl transferase, family 2
F0345_RS09870	COG1595	DNA-templated transcription, initiation
F0345_RS09900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0345_RS09910	COG2009	succinate dehydrogenase
F0345_RS09920	COG1053	succinate dehydrogenase
F0345_RS09925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0345_RS09940	COG1309	transcriptional regulator
F0345_RS09955	COG1408	metallophosphoesterase
F0345_RS09965	COG1686	Belongs to the peptidase S11 family
F0345_RS10010	COG0180	Tryptophanyl-tRNA synthetase
F0345_RS10045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0345_RS10055	COG0754	glutathionylspermidine amidase activity
F0345_RS10065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0345_RS10070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0345_RS10080	COG3655	Transcriptional regulator
F0345_RS10090	COG2362	D-Aminopeptidase
F0345_RS10115	COG4175	Glycine betaine
F0345_RS10115	COG0517	IMP dehydrogenase activity
F0345_RS10125	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS10140	COG0039	L-malate dehydrogenase activity
F0345_RS10165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0345_RS10175	COG0138	bifunctional purine biosynthesis protein purh
F0345_RS10205	COG0045	succinate-CoA ligase (ADP-forming) activity
F0345_RS10210	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F0345_RS10215	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0345_RS10220	COG0714	Associated with various cellular activities
F0345_RS10235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0345_RS10235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0345_RS10240	COG0739	heme binding
F0345_RS10240	COG1196	nuclear chromosome segregation
F0345_RS10240	COG0741	lytic transglycosylase activity
F0345_RS10245	COG2066	Belongs to the glutaminase family
F0345_RS10290	COG1228	amidohydrolase
F0345_RS10305	COG0657	acetylesterase activity
F0345_RS10325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0345_RS10330	COG2197	response regulator
F0345_RS10355	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS10365	COG0519	Catalyzes the synthesis of GMP from XMP
F0345_RS10365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0345_RS10385	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS10400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0345_RS10410	COG0516	GMP reductase activity
F0345_RS10420	COG1595	DNA-templated transcription, initiation
F0345_RS10425	COG2197	response regulator
F0345_RS10435	COG0583	DNA-binding transcription factor activity
F0345_RS10440	COG4221	oxidoreductase activity
F0345_RS10455	COG0726	polysaccharide deacetylase
F0345_RS10490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0345_RS10515	COG0802	atpase or kinase
F0345_RS10525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0345_RS10575	COG0736	holo-[acyl-carrier-protein] synthase activity
F0345_RS10585	COG4977	sequence-specific DNA binding
F0345_RS10590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0345_RS10605	COG1072	(Pantothenic acid kinase))
F0345_RS10615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0345_RS10620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0345_RS10625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0345_RS10635	COG0101	tRNA pseudouridine synthase activity
F0345_RS10640	COG0203	ribosomal protein L17
F0345_RS10650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0345_RS10655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0345_RS10660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0345_RS10665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0345_RS10675	COG0563	adenylate kinase activity
F0345_RS10680	COG0201	protein transport
F0345_RS10685	COG0200	Binds to the 23S rRNA
F0345_RS10690	COG1841	ribosomal large subunit assembly
F0345_RS10695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0345_RS10700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0345_RS10705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0345_RS10710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0345_RS10715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0345_RS10720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0345_RS10725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0345_RS10730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0345_RS10735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F0345_RS10740	COG0255	Belongs to the universal ribosomal protein uL29 family
F0345_RS10745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0345_RS10750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0345_RS10755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0345_RS10760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0345_RS10765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F0345_RS10770	COG0089	rRNA binding
F0345_RS10775	COG0088	Forms part of the polypeptide exit tunnel
F0345_RS10780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0345_RS10785	COG0051	transcription antitermination factor activity, RNA binding
F0345_RS10790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F0345_RS10800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0345_RS10805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0345_RS10810	COG0049	tRNA binding
F0345_RS10815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0345_RS10850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0345_RS10855	COG0085	RNA polymerase activity
F0345_RS10860	COG0222	ribosome binding
F0345_RS10865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0345_RS10875	COG0081	regulation of translation
F0345_RS10900	COG0436	Aminotransferase
F0345_RS10905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0345_RS10915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0345_RS10925	COG2030	dehydratase
F0345_RS10930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0345_RS10945	COG0402	S-adenosylhomocysteine deaminase activity
F0345_RS10950	COG0702	epimerase
F0345_RS10960	COG1666	GTP binding
F0345_RS10965	COG2261	transglycosylase associated protein
F0345_RS10970	COG3304	Inner membrane component domain
F0345_RS10975	COG0501	Belongs to the peptidase M48B family
F0345_RS10980	COG1007	ATP synthesis coupled electron transport
F0345_RS10990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0345_RS10995	COG0713	ATP synthesis coupled electron transport
F0345_RS11000	COG0839	Belongs to the complex I subunit 6 family
F0345_RS11005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS11010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0345_RS11025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS11030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS11040	COG4585	Histidine kinase
F0345_RS11045	COG2197	response regulator
F0345_RS11050	COG0674	pyruvate-flavodoxin oxidoreductase activity
F0345_RS11050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F0345_RS11055	COG1013	pyruvate-flavodoxin oxidoreductase activity
F0345_RS11060	COG1733	regulation of RNA biosynthetic process
F0345_RS11070	COG0488	(ABC) transporter
F0345_RS11085	COG3415	Transposase
F0345_RS11085	COG2801	Transposase and inactivated derivatives
F0345_RS11095	COG0142	geranyltranstransferase activity
F0345_RS11100	COG3104	oligopeptide transport
F0345_RS11110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0345_RS11120	COG0561	phosphatase activity
F0345_RS11150	COG1007	ATP synthesis coupled electron transport
F0345_RS11160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0345_RS11165	COG0713	ATP synthesis coupled electron transport
F0345_RS11170	COG0839	Belongs to the complex I subunit 6 family
F0345_RS11175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS11180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0345_RS11185	COG1034	ATP synthesis coupled electron transport
F0345_RS11190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F0345_RS11200	COG0649	NAD binding
F0345_RS11205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS11210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS11220	COG0791	NLP P60 protein
F0345_RS11220	COG1388	LysM domain
F0345_RS11220	COG3103	Sh3 type 3 domain protein
F0345_RS11235	COG2226	methyltransferase
F0345_RS11245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F0345_RS11295	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
F0345_RS11390	COG1674	ftsk spoiiie
F0345_RS11395	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F0345_RS11400	COG1278	Cold shock
F0345_RS11430	COG3559	Exporter of polyketide antibiotics
F0345_RS11435	COG1131	(ABC) transporter
F0345_RS11450	COG1301	dicarboxylic acid transport
F0345_RS11465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F0345_RS11480	COG0163	prenyltransferase activity
F0345_RS11485	COG0109	protoheme IX farnesyltransferase activity
F0345_RS11490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F0345_RS11505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0345_RS11515	COG0785	Cytochrome C biogenesis protein
F0345_RS11520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0345_RS11530	COG0406	alpha-ribazole phosphatase activity
F0345_RS11535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0345_RS11580	COG0659	secondary active sulfate transmembrane transporter activity
F0345_RS11585	COG1690	Belongs to the RtcB family
F0345_RS11605	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F0345_RS11610	COG0018	arginyl-trna synthetase
F0345_RS11625	COG0113	porphobilinogen synthase activity
F0345_RS11630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0345_RS11630	COG1648	precorrin-2 dehydrogenase activity
F0345_RS11635	COG0181	hydroxymethylbilane synthase activity
F0345_RS11640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0345_RS11645	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F0345_RS11695	COG0123	including yeast histone deacetylase and acetoin utilization protein
F0345_RS11730	COG0180	Tryptophanyl-tRNA synthetase
F0345_RS11735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0345_RS11745	COG0842	Transport permease protein
F0345_RS11745	COG1129	ABC transporter
F0345_RS11765	COG0129	dihydroxy-acid dehydratase activity
F0345_RS11770	COG1309	transcriptional regulator
F0345_RS11775	COG1082	Xylose isomerase domain protein TIM barrel
F0345_RS11785	COG0248	Ppx GppA phosphatase
F0345_RS11810	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F0345_RS11820	COG0671	phosphoesterase, PA-phosphatase related
F0345_RS11830	COG1595	DNA-templated transcription, initiation
F0345_RS11840	COG0745	RESPONSE REGULATOR receiver
F0345_RS11845	COG2205	protein histidine kinase activity
F0345_RS11850	COG0739	heme binding
F0345_RS11875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F0345_RS11895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F0345_RS11905	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0345_RS11910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0345_RS11925	COG2197	response regulator
F0345_RS11940	COG0649	NAD binding
F0345_RS11960	COG2197	response regulator
F0345_RS11965	COG4585	Histidine kinase
F0345_RS11985	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS12050	COG0477	Major facilitator Superfamily
F0345_RS12065	COG1174	glycine betaine transport
F0345_RS12070	COG1174	glycine betaine transport
F0345_RS12075	COG1125	glycine betaine transport
F0345_RS12075	COG0517	IMP dehydrogenase activity
F0345_RS12090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0345_RS12095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0345_RS12105	COG0302	gtp cyclohydrolase
F0345_RS12120	COG0037	tRNA processing
F0345_RS12130	COG2027	D-alanyl-D-alanine carboxypeptidase
F0345_RS12135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0345_RS12150	COG0789	Transcriptional regulator
F0345_RS12155	COG0655	NAD(P)H dehydrogenase (quinone) activity
F0345_RS12165	COG2318	DinB family
F0345_RS12170	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS12195	COG1289	transmembrane transporter activity
F0345_RS12215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0345_RS12215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0345_RS12265	COG2318	DinB family
F0345_RS12315	COG4942	peptidase
F0345_RS12355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0345_RS12390	COG0783	Belongs to the Dps family
F0345_RS12395	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0345_RS12400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS12430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0345_RS12445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0345_RS12450	COG1316	TRANSCRIPTIONal
F0345_RS12460	COG0640	Transcriptional regulator
F0345_RS12470	COG1252	NADH dehydrogenase
F0345_RS12495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0345_RS12505	COG2186	Transcriptional regulator
F0345_RS12515	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS12550	COG2197	response regulator
F0345_RS12575	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0345_RS12640	COG0596	Alpha beta hydrolase
F0345_RS12650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0345_RS12655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0345_RS12655	COG1754	DNA topoisomerase type I activity
F0345_RS12665	COG2890	protein-(glutamine-N5) methyltransferase activity
F0345_RS12680	COG1366	Belongs to the anti-sigma-factor antagonist family
F0345_RS12685	COG1111	helicase
F0345_RS12685	COG1205	dead DEAH box helicase
F0345_RS12745	COG0659	secondary active sulfate transmembrane transporter activity
F0345_RS12750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0345_RS12755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0345_RS12765	COG2267	carboxylic ester hydrolase activity
F0345_RS12795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0345_RS12805	COG0251	oxidation-reduction process
F0345_RS12820	COG0003	Pfam Anion-transporting ATPase
F0345_RS12840	COG1408	metallophosphoesterase
F0345_RS12860	COG1609	Transcriptional regulator
F0345_RS12905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0345_RS12975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0345_RS12985	COG1136	(ABC) transporter
F0345_RS12985	COG0577	efflux transmembrane transporter activity
F0345_RS13000	COG2318	DinB family
F0345_RS13025	COG0596	Alpha beta hydrolase
F0345_RS13080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0345_RS13085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0345_RS13115	COG0789	Transcriptional regulator
F0345_RS13140	COG3251	PFAM MbtH domain protein
F0345_RS13145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0345_RS13165	COG1136	(ABC) transporter
F0345_RS13165	COG0577	efflux transmembrane transporter activity
F0345_RS13205	COG2124	cytochrome p450
F0345_RS13220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0345_RS13230	COG2197	response regulator
F0345_RS13235	COG4585	Histidine kinase
F0345_RS13245	COG3844	kynureninase activity
F0345_RS13260	COG0477	Major facilitator Superfamily
F0345_RS13265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F0345_RS13270	COG0191	fructose-bisphosphate aldolase activity
F0345_RS13275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0345_RS13290	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F0345_RS13320	COG0542	response to heat
F0345_RS13345	COG0789	Transcriptional regulator
F0345_RS13350	COG0484	heat shock protein binding
F0345_RS13355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0345_RS13360	COG0443	Heat shock 70 kDa protein
F0345_RS13385	COG1725	Transcriptional regulator
F0345_RS13390	COG1131	(ABC) transporter
F0345_RS13405	COG4607	ABC-type enterochelin transport system periplasmic component
F0345_RS13420	COG1120	ATPase activity
F0345_RS13425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS13430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS13450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0345_RS13480	COG2814	Major facilitator Superfamily
F0345_RS13490	COG0717	Belongs to the dCTP deaminase family
F0345_RS13545	COG1316	TRANSCRIPTIONal
F0345_RS13560	COG2268	Band 7 protein
F0345_RS13565	COG1937	Protein conserved in bacteria
F0345_RS13605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0345_RS13615	COG0477	Major facilitator Superfamily
F0345_RS13675	COG0657	acetylesterase activity
F0345_RS13680	COG0247	lactate metabolic process
F0345_RS13680	COG2181	nitrate reductase activity
F0345_RS13695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0345_RS13710	COG1741	Belongs to the pirin family
F0345_RS13720	COG1960	acyl-CoA dehydrogenase activity
F0345_RS13740	COG1362	aminopeptidase activity
F0345_RS13800	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0345_RS13805	COG0022	dehydrogenase e1 component
F0345_RS13820	COG0515	serine threonine protein kinase
F0345_RS13825	COG0515	serine threonine protein kinase
F0345_RS13850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0345_RS13855	COG0303	'Molybdopterin
F0345_RS13860	COG0746	molybdenum cofactor guanylyltransferase activity
F0345_RS13880	COG1522	sequence-specific DNA binding
F0345_RS13920	COG1733	regulation of RNA biosynthetic process
F0345_RS13925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F0345_RS13935	COG1716	ATPase activity
F0345_RS13940	COG1716	ATPase activity
F0345_RS13960	COG0515	serine threonine protein kinase
F0345_RS13965	COG3764	Sortase (surface protein transpeptidase)
F0345_RS13970	COG3764	Sortase (surface protein transpeptidase)
F0345_RS13995	COG0705	Rhomboid family
F0345_RS14025	COG0515	serine threonine protein kinase
F0345_RS14080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0345_RS14085	COG0187	DNA topoisomerase II activity
F0345_RS14090	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F0345_RS14095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0345_RS14100	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F0345_RS14105	COG0592	DNA-directed DNA polymerase activity
F0345_RS14110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0345_RS14115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0345_RS14120	COG0594	ribonuclease P activity
F0345_RS14125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F0345_RS14130	COG0706	membrane insertase activity
F0345_RS14140	COG0357	Ribosomal RNA small subunit methyltransferase G
F0345_RS14145	COG1192	Involved in chromosome partitioning
F0345_RS14160	COG3118	belongs to the thioredoxin family
F0345_RS14165	COG0492	ferredoxin-NADP+ reductase activity
F0345_RS14175	COG1595	DNA-templated transcription, initiation
F0345_RS14180	COG0515	serine threonine protein kinase
F0345_RS14180	COG2815	serine threonine protein kinase
F0345_RS14195	COG0617	tRNA 3'-terminal CCA addition
F0345_RS14220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0345_RS14245	COG0360	Binds together with S18 to 16S ribosomal RNA
F0345_RS14250	COG0629	single-stranded DNA binding
F0345_RS14255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0345_RS14260	COG0359	binds to the 23S rRNA
F0345_RS14270	COG0305	Participates in initiation and elongation during chromosome replication
F0345_RS14280	COG0110	maltose O-acetyltransferase activity
F0345_RS14320	COG0626	cystathionine gamma-synthase activity
F0345_RS14325	COG1950	PFAM Membrane protein of
F0345_RS14330	COG0662	Cupin 2, conserved barrel domain protein
F0345_RS14355	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0345_RS14370	COG1609	Transcriptional regulator
F0345_RS14375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0345_RS14380	COG1271	oxidase subunit
F0345_RS14385	COG1294	oxidase, subunit
F0345_RS14390	COG4988	ABC transporter
F0345_RS14405	COG0561	phosphatase activity
F0345_RS14425	COG1131	(ABC) transporter
F0345_RS14445	COG0561	phosphatase activity
F0345_RS14450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0345_RS14455	COG0077	Prephenate dehydratase
F0345_RS14460	COG2837	iron assimilation
F0345_RS14475	COG1999	signal sequence binding
F0345_RS14495	COG0006	proline dipeptidase activity
F0345_RS14510	COG0653	protein targeting
F0345_RS14525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0345_RS14615	COG2188	Transcriptional regulator
F0345_RS14640	COG1595	DNA-templated transcription, initiation
F0345_RS14645	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS14675	COG0745	RESPONSE REGULATOR receiver
F0345_RS14685	COG0477	Major facilitator Superfamily
F0345_RS14705	COG0477	Major facilitator Superfamily
F0345_RS14720	COG1191	sigma factor activity
F0345_RS14725	COG1191	sigma factor activity
F0345_RS14755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0345_RS14825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0345_RS14830	COG0659	secondary active sulfate transmembrane transporter activity
F0345_RS14840	COG2824	Alkylphosphonate utilization operon protein PhnA
F0345_RS14865	COG0151	Belongs to the GarS family
F0345_RS14880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0345_RS14890	COG2197	response regulator
F0345_RS14925	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0345_RS14930	COG0047	phosphoribosylformylglycinamidine synthase activity
F0345_RS14935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0345_RS14950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0345_RS14980	COG1643	Atp-dependent helicase
F0345_RS15015	COG0513	Belongs to the DEAD box helicase family
F0345_RS15060	COG0667	Aldo Keto reductase
F0345_RS15070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0345_RS15075	COG0579	oxidoreductase
F0345_RS15090	COG0366	Alpha amylase catalytic
F0345_RS15090	COG1470	cell adhesion involved in biofilm formation
F0345_RS15270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F0345_RS15275	COG1802	Transcriptional regulator
F0345_RS15295	COG2318	DinB family
F0345_RS15315	COG0671	phosphoesterase, PA-phosphatase related
F0345_RS15325	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS15335	COG1937	Protein conserved in bacteria
F0345_RS15345	COG0306	phosphate transporter
F0345_RS15375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0345_RS15385	COG2318	DinB family
F0345_RS15460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0345_RS15470	COG1131	(ABC) transporter
F0345_RS15480	COG1725	Transcriptional regulator
F0345_RS15485	COG4941	Belongs to the sigma-70 factor family
F0345_RS15535	COG0456	acetyltransferase
F0345_RS15540	COG0737	Belongs to the 5'-nucleotidase family
F0345_RS15545	COG0235	Class ii aldolase
F0345_RS15550	COG2160	L-arabinose isomerase activity
F0345_RS15560	COG1609	Transcriptional regulator
F0345_RS15570	COG1129	ABC transporter
F0345_RS15575	COG4214	carbohydrate transport
F0345_RS15595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0345_RS15600	COG1609	Transcriptional regulator
F0345_RS15605	COG0745	RESPONSE REGULATOR receiver
F0345_RS15630	COG2897	thiosulfate sulfurtransferase activity
F0345_RS15655	COG3485	protocatechuate 3,4-dioxygenase
F0345_RS15660	COG0735	belongs to the Fur family
F0345_RS15665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0345_RS15670	COG1490	D-aminoacyl-tRNA deacylase activity
F0345_RS15685	COG0789	Transcriptional regulator
F0345_RS15755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0345_RS15795	COG0438	transferase activity, transferring glycosyl groups
F0345_RS15815	COG0588	phosphoglycerate mutase activity
F0345_RS15820	COG4974	Belongs to the 'phage' integrase family
F0345_RS15870	COG2076	Multidrug Resistance protein
F0345_RS15880	COG0704	Plays a role in the regulation of phosphate uptake
F0345_RS15885	COG5002	protein histidine kinase activity
F0345_RS15890	COG0745	RESPONSE REGULATOR receiver
F0345_RS15900	COG1329	Transcriptional regulator
F0345_RS15905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0345_RS15910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0345_RS15930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS15945	COG0215	cysteine-tRNA ligase activity
F0345_RS15970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0345_RS15980	COG3842	ATPase activity
F0345_RS16020	COG2770	Histidine kinase
F0345_RS16020	COG2208	phosphoserine phosphatase activity
F0345_RS16050	COG1278	Cold shock
F0345_RS16055	COG0513	Belongs to the DEAD box helicase family
F0345_RS16065	COG3634	alkyl hydroperoxide reductase activity
F0345_RS16075	COG4585	Histidine kinase
F0345_RS16080	COG2197	response regulator
F0345_RS16085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0345_RS16090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0345_RS16115	COG0301	tRNA thio-modification
F0345_RS16130	COG1136	(ABC) transporter
F0345_RS16130	COG0577	efflux transmembrane transporter activity
F0345_RS16135	COG1335	isochorismatase
F0345_RS16205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0345_RS16230	COG1309	transcriptional regulator
F0345_RS16255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F0345_RS16290	COG1105	Belongs to the carbohydrate kinase PfkB family
F0345_RS16295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0345_RS16305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0345_RS16385	COG0463	Glycosyl transferase, family 2
F0345_RS16400	COG1278	Cold shock
F0345_RS16435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0345_RS16440	COG1737	Transcriptional regulator
F0345_RS16445	COG0406	alpha-ribazole phosphatase activity
F0345_RS16495	COG3973	AAA domain
F0345_RS16505	COG1309	transcriptional regulator
F0345_RS16510	COG0778	Nitroreductase
F0345_RS16530	COG1061	Type III restriction enzyme res subunit
F0345_RS16565	COG2124	cytochrome p450
F0345_RS16575	COG1295	ribonuclease BN
F0345_RS16595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS16600	COG1120	ATPase activity
F0345_RS16605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0345_RS16615	COG1278	Cold shock
F0345_RS16620	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F0345_RS16625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0345_RS16635	COG2814	Major facilitator Superfamily
F0345_RS16645	COG2186	Transcriptional regulator
F0345_RS16665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0345_RS16675	COG2252	PERMEase
F0345_RS16700	COG0667	Aldo Keto reductase
F0345_RS16770	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0345_RS16775	COG2124	cytochrome p450
F0345_RS16800	COG2205	protein histidine kinase activity
F0345_RS16805	COG0277	FAD linked oxidase domain protein
F0345_RS16810	COG0583	DNA-binding transcription factor activity
F0345_RS16840	COG1131	(ABC) transporter
F0345_RS16860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0345_RS16895	COG0259	pyridoxamine-phosphate oxidase activity
F0345_RS16910	COG4821	SIS domain
F0345_RS16975	COG1366	Belongs to the anti-sigma-factor antagonist family
F0345_RS16990	COG2072	flavoprotein involved in K transport
F0345_RS17015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0345_RS17015	COG0515	serine threonine protein kinase
F0345_RS17055	COG2815	serine threonine protein kinase
F0345_RS17055	COG0515	serine threonine protein kinase
F0345_RS17085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F0345_RS17105	COG5297	Belongs to the glycosyl hydrolase family 6
F0345_RS17205	COG1278	Cold shock
F0345_RS17270	COG1609	Transcriptional regulator
F0345_RS17315	COG0582	viral genome integration into host DNA
F0345_RS17360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0345_RS17365	COG2151	metal-sulfur cluster biosynthetic enzyme
F0345_RS17370	COG3396	Phenylacetate-CoA oxygenase
F0345_RS17375	COG3460	Phenylacetate-CoA oxygenase
F0345_RS17380	COG3396	Phenylacetate-CoA oxygenase
F0345_RS17385	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS17395	COG0183	Belongs to the thiolase family
F0345_RS17405	COG2050	protein possibly involved in aromatic compounds catabolism
F0345_RS17450	COG1846	Transcriptional regulator
F0345_RS17455	COG3384	dioxygenase
F0345_RS17470	COG3191	aminopeptidase activity
F0345_RS17475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0345_RS17485	COG1970	mechanosensitive ion channel activity
F0345_RS17495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F0345_RS17510	COG3263	regulation of cellular component size
F0345_RS17520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0345_RS17525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0345_RS17535	COG0315	cyclic pyranopterin monophosphate synthase activity
F0345_RS17540	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0345_RS17540	COG0315	cyclic pyranopterin monophosphate synthase activity
F0345_RS17565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F0345_RS17590	COG2072	flavoprotein involved in K transport
F0345_RS17600	COG4221	oxidoreductase activity
F0345_RS17610	COG4946	Tricorn protease homolog
F0345_RS17610	COG0793	Belongs to the peptidase S41A family
F0345_RS17620	COG2409	Drug exporters of the RND superfamily
F0345_RS17630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0345_RS17675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F0345_RS17685	COG0305	Participates in initiation and elongation during chromosome replication
F0345_RS17780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0345_RS17805	COG0084	hydrolase, TatD family'
F0345_RS17810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0345_RS17815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F0345_RS17820	COG0488	(ABC) transporter
F0345_RS17860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0345_RS17865	COG2197	response regulator
F0345_RS17875	COG4106	trans-aconitate 2-methyltransferase activity
F0345_RS17895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0345_RS17905	COG0193	aminoacyl-tRNA hydrolase activity
F0345_RS17910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0345_RS17920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0345_RS17925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0345_RS17935	COG4585	Histidine kinase
F0345_RS17970	COG1316	TRANSCRIPTIONal
F0345_RS17985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0345_RS17995	COG0477	Major facilitator Superfamily
F0345_RS18005	COG3629	intracellular signal transduction
F0345_RS18005	COG3903	Transcriptional regulator
F0345_RS18010	COG3415	Transposase
F0345_RS18010	COG2801	Transposase and inactivated derivatives
F0345_RS18100	COG2318	DinB family
F0345_RS18150	COG0148	phosphopyruvate hydratase activity
F0345_RS18185	COG1252	NADH dehydrogenase
F0345_RS18190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0345_RS18195	COG0577	efflux transmembrane transporter activity
F0345_RS18195	COG1136	(ABC) transporter
F0345_RS18200	COG1136	(ABC) transporter
F0345_RS18220	COG1476	TRANSCRIPTIONal
F0345_RS18240	COG0183	Belongs to the thiolase family
F0345_RS18245	COG2755	lipolytic protein G-D-S-L family
F0345_RS18255	COG0667	Aldo Keto reductase
F0345_RS18275	COG0137	argininosuccinate synthase activity
F0345_RS18280	COG2175	clavaminate synthase activity
F0345_RS18290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0345_RS18300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0345_RS18315	COG3896	Chloramphenicol phosphotransferase-like protein
F0345_RS18335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0345_RS18345	COG0531	amino acid
F0345_RS18395	COG0395	ABC-type sugar transport system, permease component
F0345_RS18430	COG1228	amidohydrolase
F0345_RS18435	COG1191	sigma factor activity
F0345_RS18440	COG1366	Belongs to the anti-sigma-factor antagonist family
F0345_RS18450	COG3104	oligopeptide transport
F0345_RS18455	COG0745	RESPONSE REGULATOR receiver
F0345_RS18460	COG2205	protein histidine kinase activity
F0345_RS18475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0345_RS18500	COG2072	flavoprotein involved in K transport
F0345_RS18510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F0345_RS18520	COG0753	catalase activity
F0345_RS18525	COG1316	TRANSCRIPTIONal
F0345_RS18550	COG1316	TRANSCRIPTIONal
F0345_RS18580	COG0778	Nitroreductase
F0345_RS18580	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F0345_RS18585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0345_RS18620	COG1620	l-lactate permease
F0345_RS18630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0345_RS18635	COG2835	tetraacyldisaccharide 4'-kinase activity
F0345_RS18645	COG1482	cell wall glycoprotein biosynthetic process
F0345_RS18655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F0345_RS18705	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F0345_RS18710	COG0745	RESPONSE REGULATOR receiver
F0345_RS18715	COG5002	protein histidine kinase activity
F0345_RS18720	COG0823	Involved in the tonB-independent uptake of proteins
F0345_RS18730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0345_RS18735	COG2197	response regulator
F0345_RS18740	COG3214	Protein conserved in bacteria
F0345_RS18745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0345_RS18750	COG0653	protein targeting
F0345_RS18775	COG2902	Dehydrogenase
F0345_RS18800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F0345_RS18805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F0345_RS18810	COG0438	transferase activity, transferring glycosyl groups
F0345_RS18815	COG1216	Glycosyl transferase, family 2
F0345_RS18820	COG0395	ABC-type sugar transport system, permease component
F0345_RS18825	COG1175	transmembrane transport
F0345_RS18840	COG1716	ATPase activity
F0345_RS18845	COG0515	serine threonine protein kinase
F0345_RS18850	COG0515	serine threonine protein kinase
F0345_RS18855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F0345_RS18870	COG2884	Cell division ATP-binding protein ftsE
F0345_RS18880	COG0793	Belongs to the peptidase S41A family
F0345_RS18885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0345_RS18900	COG0583	DNA-binding transcription factor activity
F0345_RS18945	COG3973	AAA domain
F0345_RS18945	COG3973	AAA domain
F0345_RS18955	COG0776	regulation of translation
F0345_RS18960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0345_RS18965	COG1678	Uncharacterized ACR, COG1678
F0345_RS18985	COG0395	ABC-type sugar transport system, permease component
F0345_RS18990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0345_RS19005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0345_RS19020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0345_RS19050	COG2318	DinB family
F0345_RS19095	COG1174	glycine betaine transport
F0345_RS19100	COG1125	glycine betaine transport
F0345_RS19100	COG0517	IMP dehydrogenase activity
F0345_RS19105	COG1174	glycine betaine transport
F0345_RS19115	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F0345_RS19120	COG0277	FAD linked oxidase domain protein
F0345_RS19155	COG1335	isochorismatase
F0345_RS19165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0345_RS19180	COG1113	amino acid transport
F0345_RS19205	COG1234	tRNA 3'-trailer cleavage
F0345_RS19215	COG1263	PTS System
F0345_RS19220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0345_RS19225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F0345_RS19235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F0345_RS19260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0345_RS19275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0345_RS19305	COG2733	membrane
F0345_RS19310	COG2271	Major facilitator Superfamily
F0345_RS19335	COG0706	membrane insertase activity
F0345_RS19340	COG0179	Fumarylacetoacetate (FAA) hydrolase
F0345_RS19345	COG0673	inositol 2-dehydrogenase activity
F0345_RS19400	COG3397	chitin binding
F0345_RS19420	COG1126	abc transporter atp-binding protein
F0345_RS19425	COG0765	amino acid transport
F0345_RS19430	COG0765	amino acid transport
F0345_RS19435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0345_RS19455	COG3473	Maleate cis-trans isomerase
F0345_RS19465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0345_RS19510	COG1554	hydrolase, family 65, central catalytic
F0345_RS19560	COG1217	gtp-binding protein TYPA
F0345_RS19575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS19580	COG0444	Belongs to the ABC transporter superfamily
F0345_RS19585	COG4608	Belongs to the ABC transporter superfamily
F0345_RS19595	COG0601	transmembrane transport
F0345_RS19600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS19610	COG4608	Belongs to the ABC transporter superfamily
F0345_RS19625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F0345_RS19645	COG3250	beta-galactosidase activity
F0345_RS19650	COG1879	ABC-type sugar transport system periplasmic component
F0345_RS19655	COG1129	ABC transporter
F0345_RS19665	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0345_RS19670	COG1609	Transcriptional regulator
F0345_RS19680	COG2912	Transglutaminase-like superfamily
F0345_RS19715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0345_RS19750	COG0519	Catalyzes the synthesis of GMP from XMP
F0345_RS19760	COG1024	Enoyl-CoA hydratase
F0345_RS19775	COG1595	DNA-templated transcription, initiation
F0345_RS19785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0345_RS19790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0345_RS19830	COG0598	Magnesium transport protein CorA
F0345_RS19840	COG2814	Major facilitator Superfamily
F0345_RS19845	COG0613	PHP domain protein
F0345_RS19850	COG2095	MarC family integral membrane protein
F0345_RS19860	COG1432	Conserved Protein
F0345_RS19870	COG0513	Belongs to the DEAD box helicase family
F0345_RS19935	COG0596	Alpha beta hydrolase
F0345_RS19960	COG0210	DNA helicase
F0345_RS20055	COG3480	Lon protease (S16) C-terminal proteolytic domain
F0345_RS20065	COG1615	UPF0182 protein
F0345_RS20090	COG0753	catalase activity
F0345_RS20095	COG0483	inositol monophosphate 1-phosphatase activity
F0345_RS20100	COG2076	Multidrug Resistance protein
F0345_RS20110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0345_RS20120	COG2135	peptidase activity
F0345_RS20130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0345_RS20140	COG1595	DNA-templated transcription, initiation
F0345_RS20145	COG5662	AntiSigma factor
F0345_RS20155	COG0242	peptide deformylase activity
F0345_RS20165	COG2124	cytochrome p450
F0345_RS20185	COG1966	Carbon starvation protein
F0345_RS20190	COG2188	Transcriptional regulator
F0345_RS20195	COG2182	Extracellular solute-binding protein
F0345_RS20200	COG1175	transmembrane transport
F0345_RS20205	COG0395	ABC-type sugar transport system, permease component
F0345_RS20210	COG1472	Belongs to the glycosyl hydrolase 3 family
F0345_RS20215	COG0363	glucosamine-6-phosphate deaminase activity
F0345_RS20230	COG1597	lipid kinase activity
F0345_RS20245	COG2172	sigma factor antagonist activity
F0345_RS20280	COG1959	2 iron, 2 sulfur cluster binding
F0345_RS20285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0345_RS20290	COG0142	geranyltranstransferase activity
F0345_RS20335	COG4106	trans-aconitate 2-methyltransferase activity
F0345_RS20340	COG1126	abc transporter atp-binding protein
F0345_RS20355	COG0281	malic enzyme
F0345_RS20360	COG0604	alcohol dehydrogenase
F0345_RS20400	COG2255	four-way junction helicase activity
F0345_RS20430	COG0567	Dehydrogenase, E1 component
F0345_RS20430	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0345_RS20435	COG2205	protein histidine kinase activity
F0345_RS20440	COG0745	RESPONSE REGULATOR receiver
F0345_RS20460	COG1131	(ABC) transporter
F0345_RS20470	COG1595	DNA-templated transcription, initiation
F0345_RS20485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0345_RS20490	COG0726	polysaccharide deacetylase
F0345_RS20555	COG0768	penicillin binding
F0345_RS20560	COG0772	Belongs to the SEDS family
F0345_RS20570	COG1793	dna ligase
F0345_RS20570	COG3285	dna ligase
F0345_RS20575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F0345_RS20580	COG2267	carboxylic ester hydrolase activity
F0345_RS20590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0345_RS20590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0345_RS20595	COG1191	sigma factor activity
F0345_RS20605	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS20635	COG0018	arginyl-trna synthetase
F0345_RS20640	COG0019	diaminopimelate decarboxylase activity
F0345_RS20645	COG0460	homoserine dehydrogenase
F0345_RS20650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F0345_RS20655	COG0083	homoserine kinase activity
F0345_RS20665	COG1316	TRANSCRIPTIONal
F0345_RS20670	COG0254	rRNA binding
F0345_RS20675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0345_RS20680	COG2890	protein-(glutamine-N5) methyltransferase activity
F0345_RS20690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0345_RS20695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0345_RS20710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0345_RS20715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0345_RS20720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0345_RS20725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0345_RS20730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0345_RS20735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0345_RS20740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0345_RS20760	COG2197	response regulator
F0345_RS20765	COG4585	Histidine kinase
F0345_RS20780	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS20790	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS20800	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F0345_RS20835	COG1131	(ABC) transporter
F0345_RS20855	COG0183	Belongs to the thiolase family
F0345_RS20870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0345_RS20875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0345_RS20895	COG0832	Belongs to the urease beta subunit family
F0345_RS20900	COG0804	urea catabolic process
F0345_RS20910	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F0345_RS20915	COG0829	nickel cation binding
F0345_RS20945	COG2205	protein histidine kinase activity
F0345_RS21015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0345_RS21015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0345_RS21055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0345_RS21060	COG0280	phosphate acetyltransferase
F0345_RS21060	COG0857	belongs to the CobB CobQ family
F0345_RS21065	COG0205	6-phosphofructokinase activity
F0345_RS21070	COG4565	transcriptional regulatory protein
F0345_RS21075	COG3290	protein histidine kinase activity
F0345_RS21080	COG1301	dicarboxylic acid transport
F0345_RS21100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0345_RS21105	COG3281	Trehalose synthase
F0345_RS21110	COG0366	Alpha amylase catalytic
F0345_RS21115	COG0366	Alpha amylase catalytic
F0345_RS21135	COG1132	(ABC) transporter
F0345_RS21140	COG1132	(ABC) transporter
F0345_RS21145	COG1131	(ABC) transporter
F0345_RS21165	COG1376	ErfK ybiS ycfS ynhG family protein
F0345_RS21190	COG2085	NADP oxidoreductase coenzyme F420-dependent
F0345_RS21215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0345_RS21250	COG1760	l-serine dehydratase
F0345_RS21255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0345_RS21260	COG0509	glycine decarboxylation via glycine cleavage system
F0345_RS21265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0345_RS21285	COG4166	transmembrane transport
F0345_RS21290	COG0601	transmembrane transport
F0345_RS21295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS21300	COG0444	Belongs to the ABC transporter superfamily
F0345_RS21305	COG4608	Belongs to the ABC transporter superfamily
F0345_RS21310	COG2860	membrane
F0345_RS21335	COG0482	sulfurtransferase activity
F0345_RS21355	COG4221	oxidoreductase activity
F0345_RS21365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0345_RS21375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F0345_RS21380	COG0154	amidase activity
F0345_RS21390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F0345_RS21395	COG2409	Drug exporters of the RND superfamily
F0345_RS21415	COG1672	PFAM Archaeal ATPase
F0345_RS21415	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F0345_RS21425	COG2133	pyrroloquinoline quinone binding
F0345_RS21430	COG0667	Aldo Keto reductase
F0345_RS21450	COG0440	acetolactate synthase activity
F0345_RS21455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0345_RS21460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0345_RS21465	COG2890	protein-(glutamine-N5) methyltransferase activity
F0345_RS21480	COG3835	regulator
F0345_RS21485	COG0506	proline dehydrogenase activity
F0345_RS21490	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS21505	COG0575	Belongs to the CDS family
F0345_RS21520	COG0473	3-isopropylmalate dehydrogenase activity
F0345_RS21525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0345_RS21535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0345_RS21600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0345_RS21620	COG2018	Roadblock/LC7 domain
F0345_RS21640	COG2018	Roadblock/LC7 domain
F0345_RS21655	COG0179	Fumarylacetoacetate (FAA) hydrolase
F0345_RS21660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0345_RS21695	COG1414	Transcriptional regulator
F0345_RS21700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0345_RS21705	COG0066	3-isopropylmalate dehydratase activity
F0345_RS21715	COG0776	regulation of translation
F0345_RS21725	COG1920	GTP binding
F0345_RS21735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0345_RS21740	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0345_RS21760	COG0351	phosphomethylpyrimidine kinase
F0345_RS21765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0345_RS21770	COG1461	Dihydroxyacetone kinase
F0345_RS21780	COG0742	ribosomal rna small subunit methyltransferase
F0345_RS21785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0345_RS21800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0345_RS21805	COG0571	ribonuclease III activity
F0345_RS21810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0345_RS21815	COG2340	Cysteine-rich secretory protein family
F0345_RS21820	COG1254	Belongs to the acylphosphatase family
F0345_RS21830	COG1196	nuclear chromosome segregation
F0345_RS21835	COG0477	Major facilitator Superfamily
F0345_RS21865	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0345_RS21875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0345_RS21890	COG0228	four-way junction DNA binding
F0345_RS21895	COG1837	Belongs to the UPF0109 family
F0345_RS21900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0345_RS21905	COG0336	Belongs to the RNA methyltransferase TrmD family
F0345_RS21910	COG0335	large ribosomal subunit rRNA binding
F0345_RS21915	COG0681	Belongs to the peptidase S26 family
F0345_RS21925	COG0681	Belongs to the peptidase S26 family
F0345_RS21930	COG0681	Belongs to the peptidase S26 family
F0345_RS21945	COG0792	nuclease activity
F0345_RS21960	COG1191	sigma factor activity
F0345_RS21970	COG1388	LysM domain
F0345_RS21970	COG4942	peptidase
F0345_RS21975	COG0052	Belongs to the universal ribosomal protein uS2 family
F0345_RS21980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0345_RS21985	COG0528	UMP kinase activity
F0345_RS21990	COG0233	cytoplasmic translational termination
F0345_RS22000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F0345_RS22015	COG3842	ATPase activity
F0345_RS22035	COG1136	(ABC) transporter
F0345_RS22040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F0345_RS22050	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS22060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0345_RS22085	COG3842	ATPase activity
F0345_RS22095	COG1177	transmembrane transport
F0345_RS22100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0345_RS22130	COG2508	Transcriptional regulator
F0345_RS22130	COG2508	Transcriptional regulator
F0345_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS22140	COG1940	carbohydrate kinase activity
F0345_RS22145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0345_RS22150	COG0750	zinc metalloprotease
F0345_RS22155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0345_RS22170	COG0747	negative chemotaxis
F0345_RS22175	COG0601	transmembrane transport
F0345_RS22180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS22200	COG0442	prolyl-tRNA aminoacylation
F0345_RS22220	COG0779	Required for maturation of 30S ribosomal subunits
F0345_RS22235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0345_RS22245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0345_RS22250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F0345_RS22265	COG1357	PFAM Pentapeptide repeats (8 copies)
F0345_RS22280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0345_RS22285	COG0601	transmembrane transport
F0345_RS22290	COG0747	negative chemotaxis
F0345_RS22295	COG0455	bacterial-type flagellum organization
F0345_RS22305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0345_RS22310	COG1185	polyribonucleotide nucleotidyltransferase activity
F0345_RS22315	COG0612	Peptidase, M16
F0345_RS22320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0345_RS22340	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F0345_RS22345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0345_RS22350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F0345_RS22380	COG2208	phosphoserine phosphatase activity
F0345_RS22380	COG2770	Histidine kinase
F0345_RS22385	COG4999	Histidine kinase
F0345_RS22385	COG2205	protein histidine kinase activity
F0345_RS22385	COG3850	Histidine kinase
F0345_RS22385	COG3437	response regulator, receiver
F0345_RS22395	COG1674	ftsk spoiiie
F0345_RS22405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0345_RS22415	COG1546	Belongs to the CinA family
F0345_RS22415	COG1058	Belongs to the CinA family
F0345_RS22420	COG1396	sequence-specific DNA binding
F0345_RS22425	COG0783	Belongs to the Dps family
F0345_RS22435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0345_RS22455	COG1201	RNA secondary structure unwinding
F0345_RS22480	COG0628	permease
F0345_RS22490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0345_RS22495	COG2137	regulation of response to DNA damage stimulus
F0345_RS22510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0345_RS22515	COG0765	amino acid transport
F0345_RS22520	COG0765	amino acid transport
F0345_RS22525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0345_RS22530	COG1126	abc transporter atp-binding protein
F0345_RS22535	COG0745	RESPONSE REGULATOR receiver
F0345_RS22540	COG2205	protein histidine kinase activity
F0345_RS22550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0345_RS22570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0345_RS22580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0345_RS22585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0345_RS22595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0345_RS22635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0345_RS22640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0345_RS22645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0345_RS22680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0345_RS22710	COG1802	Transcriptional regulator
F0345_RS22715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0345_RS22730	COG0187	DNA topoisomerase II activity
F0345_RS22750	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS22755	COG0523	cobalamin synthesis protein
F0345_RS22760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0345_RS22765	COG0612	Peptidase, M16
F0345_RS22785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0345_RS22835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0345_RS22840	COG0483	inositol monophosphate 1-phosphatase activity
F0345_RS22850	COG0745	RESPONSE REGULATOR receiver
F0345_RS22855	COG2205	protein histidine kinase activity
F0345_RS22880	COG0756	dUTP diphosphatase activity
F0345_RS22900	COG0577	efflux transmembrane transporter activity
F0345_RS22900	COG1136	(ABC) transporter
F0345_RS22930	COG0569	domain protein
F0345_RS22935	COG0531	amino acid
F0345_RS22940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0345_RS22965	COG2815	serine threonine protein kinase
F0345_RS22965	COG0515	serine threonine protein kinase
F0345_RS23015	COG0488	(ABC) transporter
F0345_RS23050	COG0612	Peptidase, M16
F0345_RS23060	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS23065	COG3415	Transposase
F0345_RS23065	COG2801	Transposase and inactivated derivatives
F0345_RS23075	COG3293	Transposase
F0345_RS23135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0345_RS23135	COG0515	serine threonine protein kinase
F0345_RS23145	COG1063	alcohol dehydrogenase
F0345_RS23150	COG0395	ABC-type sugar transport system, permease component
F0345_RS23165	COG1349	DNA-binding transcription factor activity
F0345_RS23225	COG1127	ABC transporter
F0345_RS23235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0345_RS23260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0345_RS23295	COG0656	L-ascorbic acid biosynthetic process
F0345_RS23310	COG0473	3-isopropylmalate dehydrogenase activity
F0345_RS23340	COG0252	asparaginase activity
F0345_RS23345	COG0738	Major facilitator superfamily
F0345_RS23350	COG3226	Transcriptional regulator
F0345_RS23380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0345_RS23400	COG0640	Transcriptional regulator
F0345_RS23420	COG2050	protein possibly involved in aromatic compounds catabolism
F0345_RS23430	COG3540	Alkaline phosphatase
F0345_RS23435	COG2936	dipeptidyl-peptidase activity
F0345_RS23450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F0345_RS23465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS23470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS23475	COG1120	ATPase activity
F0345_RS23490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0345_RS23500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0345_RS23550	COG1620	l-lactate permease
F0345_RS23555	COG0247	lactate metabolic process
F0345_RS23560	COG1139	Iron-sulfur cluster binding protein
F0345_RS23565	COG1556	Lactate utilization protein
F0345_RS23580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F0345_RS23585	COG1799	cell septum assembly
F0345_RS23630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F0345_RS23635	COG0531	amino acid
F0345_RS23665	COG2124	cytochrome p450
F0345_RS23675	COG2111	Na H antiporter
F0345_RS23675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0345_RS23680	COG1006	Multisubunit Na H antiporter MnhC subunit
F0345_RS23685	COG0651	ATP synthesis coupled electron transport
F0345_RS23700	COG1320	monovalent cation:proton antiporter activity
F0345_RS23705	COG2235	arginine
F0345_RS23730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0345_RS23755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F0345_RS23760	COG1653	transport
F0345_RS23765	COG1175	transmembrane transport
F0345_RS23770	COG0395	ABC-type sugar transport system, permease component
F0345_RS23780	COG4213	ABC transporter substrate-binding protein
F0345_RS23790	COG4214	carbohydrate transport
F0345_RS23795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0345_RS23800	COG0531	amino acid
F0345_RS23825	COG2843	Capsule synthesis protein
F0345_RS23850	COG1024	Enoyl-CoA hydratase
F0345_RS23850	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS23855	COG0183	Belongs to the thiolase family
F0345_RS23875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0345_RS23880	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0345_RS23890	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F0345_RS23895	COG3253	May function as heme-dependent peroxidase
F0345_RS23905	COG3220	belongs to the UPF0276 family
F0345_RS23915	COG0726	polysaccharide deacetylase
F0345_RS23945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0345_RS23950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0345_RS24010	COG2176	DNA-directed DNA polymerase activity
F0345_RS24010	COG5002	protein histidine kinase activity
F0345_RS24035	COG0386	Belongs to the glutathione peroxidase family
F0345_RS24050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F0345_RS24055	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F0345_RS24080	COG0529	Catalyzes the synthesis of activated sulfate
F0345_RS24085	COG0175	sulfate reduction
F0345_RS24095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0345_RS24115	COG2130	NADP-dependent
F0345_RS24120	COG1960	acyl-CoA dehydrogenase activity
F0345_RS24175	COG1120	ATPase activity
F0345_RS24180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS24190	COG2409	Drug exporters of the RND superfamily
F0345_RS24195	COG1846	Transcriptional regulator
F0345_RS24200	COG0702	epimerase
F0345_RS24220	COG2226	methyltransferase
F0345_RS24255	COG1595	DNA-templated transcription, initiation
F0345_RS24285	COG2365	Tyrosine phosphatase family
F0345_RS24300	COG1162	GTPase activity
F0345_RS24305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0345_RS24325	COG0028	Belongs to the TPP enzyme family
F0345_RS24345	COG1802	Transcriptional regulator
F0345_RS24355	COG3835	regulator
F0345_RS24370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0345_RS24375	COG2252	PERMEase
F0345_RS24400	COG2197	response regulator
F0345_RS24405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0345_RS24410	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS24420	COG3960	tartronate-semialdehyde synthase activity
F0345_RS24430	COG0753	catalase activity
F0345_RS24435	COG2084	Dehydrogenase
F0345_RS24440	COG3622	Belongs to the hyi family
F0345_RS24460	COG2351	hydroxyisourate hydrolase activity
F0345_RS24475	COG2233	PERMEase
F0345_RS24505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0345_RS24525	COG0784	Response regulator, receiver
F0345_RS24525	COG2205	protein histidine kinase activity
F0345_RS24535	COG2172	sigma factor antagonist activity
F0345_RS24540	COG1366	Belongs to the anti-sigma-factor antagonist family
F0345_RS24545	COG1366	Belongs to the anti-sigma-factor antagonist family
F0345_RS24560	COG1116	anion transmembrane transporter activity
F0345_RS24570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F0345_RS24580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0345_RS24585	COG0583	DNA-binding transcription factor activity
F0345_RS24600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0345_RS24605	COG2080	2 iron, 2 sulfur cluster binding
F0345_RS24610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F0345_RS24615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0345_RS24630	COG1414	Transcriptional regulator
F0345_RS24635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0345_RS24650	COG4585	Histidine kinase
F0345_RS24655	COG2197	response regulator
F0345_RS24665	COG0673	inositol 2-dehydrogenase activity
F0345_RS24670	COG2188	Transcriptional regulator
F0345_RS24680	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0345_RS24690	COG1940	carbohydrate kinase activity
F0345_RS24700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0345_RS24710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0345_RS24735	COG2375	cellular response to nickel ion
F0345_RS24740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS24750	COG1120	ATPase activity
F0345_RS24770	COG1132	(ABC) transporter
F0345_RS24775	COG1132	(ABC) transporter
F0345_RS24790	COG0477	Major facilitator Superfamily
F0345_RS24795	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS24820	COG1175	transmembrane transport
F0345_RS24825	COG0395	ABC-type sugar transport system, permease component
F0345_RS24835	COG1874	Beta-galactosidase
F0345_RS24840	COG1472	Belongs to the glycosyl hydrolase 3 family
F0345_RS24845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0345_RS24870	COG1126	abc transporter atp-binding protein
F0345_RS24875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0345_RS24880	COG0765	amino acid transport
F0345_RS24885	COG0765	amino acid transport
F0345_RS24915	COG0405	Gamma-glutamyltransferase
F0345_RS24935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0345_RS24955	COG0095	Lipoate-protein ligase
F0345_RS24960	COG0405	Gamma-glutamyltransferase
F0345_RS24965	COG0483	inositol monophosphate 1-phosphatase activity
F0345_RS24980	COG0235	Class ii aldolase
F0345_RS24990	COG0159	tryptophan synthase activity
F0345_RS25010	COG0488	(ABC) transporter
F0345_RS25015	COG1929	Belongs to the glycerate kinase type-1 family
F0345_RS25025	COG0688	phosphatidylethanolamine metabolic process
F0345_RS25040	COG2301	Belongs to the HpcH HpaI aldolase family
F0345_RS25045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0345_RS25045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0345_RS25050	COG0604	alcohol dehydrogenase
F0345_RS25060	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS25065	COG1120	ATPase activity
F0345_RS25070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS25075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0345_RS25120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0345_RS25130	COG1619	proteins homologs of microcin C7 resistance protein MccF
F0345_RS25135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0345_RS25155	COG4106	trans-aconitate 2-methyltransferase activity
F0345_RS25160	COG1597	lipid kinase activity
F0345_RS25170	COG0693	protein deglycase activity
F0345_RS25255	COG2154	pterin-4-alpha-carbinolamine dehydratase
F0345_RS25265	COG2264	protein methyltransferase activity
F0345_RS25280	COG0583	DNA-binding transcription factor activity
F0345_RS25290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F0345_RS25305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0345_RS25310	COG1940	carbohydrate kinase activity
F0345_RS25310	COG1846	Transcriptional regulator
F0345_RS25315	COG1129	ABC transporter
F0345_RS25320	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0345_RS25330	COG0673	inositol 2-dehydrogenase activity
F0345_RS25395	COG1295	ribonuclease BN
F0345_RS25415	COG1609	Transcriptional regulator
F0345_RS25420	COG1129	ABC transporter
F0345_RS25430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0345_RS25435	COG1869	D-ribose catabolic process
F0345_RS25445	COG2259	Doxx family
F0345_RS25485	COG2304	oxidoreductase activity
F0345_RS25510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F0345_RS25510	COG1672	PFAM Archaeal ATPase
F0345_RS25515	COG1024	Enoyl-CoA hydratase
F0345_RS25520	COG1793	dna ligase
F0345_RS25530	COG0254	rRNA binding
F0345_RS25560	COG0438	transferase activity, transferring glycosyl groups
F0345_RS25575	COG2197	response regulator
F0345_RS25605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0345_RS25605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0345_RS25625	COG1515	deoxyribonuclease V activity
F0345_RS25635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0345_RS25645	COG0183	Belongs to the thiolase family
F0345_RS25650	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS25650	COG1024	Enoyl-CoA hydratase
F0345_RS25655	COG0789	Transcriptional regulator
F0345_RS25660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0345_RS25700	COG1024	Enoyl-CoA hydratase
F0345_RS25710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F0345_RS25725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0345_RS25750	COG1134	teichoic acid transport
F0345_RS25755	COG1562	ergosterol biosynthetic process
F0345_RS25765	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F0345_RS25775	COG1657	PFAM Prenyltransferase squalene oxidase
F0345_RS25810	COG2755	lipolytic protein G-D-S-L family
F0345_RS25855	COG2267	carboxylic ester hydrolase activity
F0345_RS25870	COG3958	Transketolase
F0345_RS25875	COG3959	Transketolase, thiamine diphosphate binding domain
F0345_RS25895	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS25925	COG0740	serine-type endopeptidase activity
F0345_RS25930	COG0740	serine-type endopeptidase activity
F0345_RS25970	COG1960	acyl-CoA dehydrogenase activity
F0345_RS25975	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS25980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F0345_RS25985	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F0345_RS25990	COG0583	DNA-binding transcription factor activity
F0345_RS26000	COG0477	Major facilitator Superfamily
F0345_RS26055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0345_RS26055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0345_RS26060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0345_RS26065	COG0297	glycogen (starch) synthase activity
F0345_RS26075	COG0859	PFAM glycosyl transferase family 9
F0345_RS26080	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0345_RS26090	COG2192	nodulation
F0345_RS26095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0345_RS26115	COG0531	amino acid
F0345_RS26155	COG1233	COG1233 Phytoene dehydrogenase and related
F0345_RS26160	COG2130	NADP-dependent
F0345_RS26165	COG2124	cytochrome p450
F0345_RS26200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0345_RS26240	COG2018	Roadblock/LC7 domain
F0345_RS26255	COG1946	Acyl-CoA thioesterase
F0345_RS26270	COG1132	(ABC) transporter
F0345_RS26275	COG1132	(ABC) transporter
F0345_RS26295	COG1132	(ABC) transporter
F0345_RS26300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0345_RS26310	COG0432	Pfam Uncharacterised protein family UPF0047
F0345_RS26320	COG1595	DNA-templated transcription, initiation
F0345_RS26330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0345_RS26340	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS26380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0345_RS26385	COG0019	diaminopimelate decarboxylase activity
F0345_RS26390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0345_RS26395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0345_RS26415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0345_RS26420	COG1121	(ABC) transporter
F0345_RS26430	COG0523	cobalamin synthesis protein
F0345_RS26470	COG2814	Major facilitator Superfamily
F0345_RS26490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0345_RS26495	COG1522	sequence-specific DNA binding
F0345_RS26510	COG2706	6-phosphogluconolactonase activity
F0345_RS26525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0345_RS26540	COG1902	pentaerythritol trinitrate reductase activity
F0345_RS26545	COG0640	Transcriptional regulator
F0345_RS26580	COG0671	phosphoesterase, PA-phosphatase related
F0345_RS26600	COG1846	Transcriptional regulator
F0345_RS26615	COG0584	glycerophosphoryl diester phosphodiesterase
F0345_RS26655	COG2086	electron transfer activity
F0345_RS26660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F0345_RS26670	COG1609	Transcriptional regulator
F0345_RS26695	COG5002	protein histidine kinase activity
F0345_RS26700	COG0745	RESPONSE REGULATOR receiver
F0345_RS26715	COG2223	nitrite transmembrane transporter activity
F0345_RS26725	COG1940	carbohydrate kinase activity
F0345_RS26745	COG1349	DNA-binding transcription factor activity
F0345_RS26780	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0345_RS26800	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS26840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0345_RS26850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0345_RS26855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0345_RS26860	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F0345_RS26860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0345_RS26860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0345_RS26870	COG1349	DNA-binding transcription factor activity
F0345_RS26885	COG0346	lactoylglutathione lyase activity
F0345_RS26900	COG0326	Molecular chaperone. Has ATPase activity
F0345_RS26920	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS26925	COG0726	polysaccharide deacetylase
F0345_RS26970	COG1595	DNA-templated transcription, initiation
F0345_RS27000	COG0328	RNA-DNA hybrid ribonuclease activity
F0345_RS27015	COG0477	Major facilitator Superfamily
F0345_RS27040	COG3340	Belongs to the peptidase S51 family
F0345_RS27070	COG2197	response regulator
F0345_RS27075	COG3851	Histidine kinase
F0345_RS27135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0345_RS27145	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0345_RS27145	COG1902	pentaerythritol trinitrate reductase activity
F0345_RS27155	COG4733	cellulase activity
F0345_RS27155	COG5297	Belongs to the glycosyl hydrolase family 6
F0345_RS27165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS27175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0345_RS27185	COG0713	ATP synthesis coupled electron transport
F0345_RS27190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0345_RS27195	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0345_RS27200	COG1007	ATP synthesis coupled electron transport
F0345_RS27220	COG2267	carboxylic ester hydrolase activity
F0345_RS27235	COG2084	Dehydrogenase
F0345_RS27265	COG2356	endonuclease I
F0345_RS27275	COG2813	Specifically methylates the guanine in position
F0345_RS27280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0345_RS27285	COG0589	response to stress
F0345_RS27290	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS27330	COG0277	FAD linked oxidase domain protein
F0345_RS27345	COG1793	dna ligase
F0345_RS27395	COG0475	glutathione-regulated potassium exporter activity
F0345_RS27420	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS27425	COG2226	methyltransferase
F0345_RS27435	COG3425	synthase
F0345_RS27440	COG1024	Enoyl-CoA hydratase
F0345_RS27445	COG2070	2-Nitropropane dioxygenase
F0345_RS27445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F0345_RS27455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0345_RS27470	COG0318	PFAM AMP-dependent synthetase and ligase
F0345_RS27470	COG3321	synthase
F0345_RS27470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0345_RS27470	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS27470	COG0300	oxidoreductase activity
F0345_RS27475	COG0300	oxidoreductase activity
F0345_RS27475	COG3321	synthase
F0345_RS27475	COG4221	oxidoreductase activity
F0345_RS27475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0345_RS27490	COG3425	synthase
F0345_RS27495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0345_RS27500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0345_RS27550	COG4172	Belongs to the ABC transporter superfamily
F0345_RS27560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F0345_RS27580	COG0741	lytic transglycosylase activity
F0345_RS27580	COG0739	heme binding
F0345_RS27580	COG1196	nuclear chromosome segregation
F0345_RS27585	COG2066	Belongs to the glutaminase family
F0345_RS27600	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F0345_RS27605	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F0345_RS27610	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F0345_RS27625	COG0789	Transcriptional regulator
F0345_RS27645	COG1309	transcriptional regulator
F0345_RS27650	COG3246	L-lysine catabolic process to acetate
F0345_RS27655	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0345_RS27695	COG0515	serine threonine protein kinase
F0345_RS27730	COG1404	Belongs to the peptidase S8 family
F0345_RS27740	COG0387	Pfam Sodium calcium exchanger
F0345_RS27765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0345_RS27810	COG1162	GTPase activity
F0345_RS27815	COG2226	methyltransferase
F0345_RS27860	COG0667	Aldo Keto reductase
F0345_RS27890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F0345_RS27890	COG0426	domain, Protein
F0345_RS27900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0345_RS27910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0345_RS27935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0345_RS27945	COG0494	nUDIX hydrolase
F0345_RS27950	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F0345_RS28055	COG1959	2 iron, 2 sulfur cluster binding
F0345_RS28060	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS28120	COG1012	belongs to the aldehyde dehydrogenase family
F0345_RS28145	COG2197	response regulator
F0345_RS28160	COG4585	Histidine kinase
F0345_RS28175	COG2801	Transposase and inactivated derivatives
F0345_RS28250	COG2197	response regulator
F0345_RS28280	COG0402	S-adenosylhomocysteine deaminase activity
F0345_RS28330	COG1136	(ABC) transporter
F0345_RS28335	COG0577	efflux transmembrane transporter activity
F0345_RS28355	COG1131	(ABC) transporter
F0345_RS28435	COG2072	flavoprotein involved in K transport
F0345_RS28440	COG0640	Transcriptional regulator
F0345_RS28450	COG2072	flavoprotein involved in K transport
F0345_RS28455	COG0798	PFAM Bile acid sodium symporter
F0345_RS28465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0345_RS28470	COG0492	ferredoxin-NADP+ reductase activity
F0345_RS28485	COG1131	(ABC) transporter
F0345_RS28500	COG4585	Histidine kinase
F0345_RS28505	COG2197	response regulator
F0345_RS28515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0345_RS28520	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0345_RS28530	COG1129	ABC transporter
F0345_RS28535	COG1869	D-ribose catabolic process
F0345_RS28540	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0345_RS28545	COG2188	Transcriptional regulator
F0345_RS28610	COG1959	2 iron, 2 sulfur cluster binding
F0345_RS28615	COG1028	Short-chain dehydrogenase reductase Sdr
F0345_RS28635	COG1192	Involved in chromosome partitioning
F0345_RS28640	COG1475	DNA binding
F0345_RS28840	COG1518	maintenance of DNA repeat elements
F0345_RS28845	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F0345_RS29085	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
F0345_RS29160	COG3547	Transposase (IS116 IS110 IS902 family)
F0345_RS29200	COG3409	Peptidoglycan-binding domain 1 protein