locus-tag	class	description
D0Z67_RS00015	COG0778	Nitroreductase
D0Z67_RS00035	COG4946	Tricorn protease homolog
D0Z67_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
D0Z67_RS00035	COG1506	peptidase
D0Z67_RS00050	COG3590	peptidase
D0Z67_RS00150	COG0673	inositol 2-dehydrogenase activity
D0Z67_RS00155	COG1879	ABC-type sugar transport system periplasmic component
D0Z67_RS00160	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS00165	COG1129	ABC transporter
D0Z67_RS00170	COG1940	carbohydrate kinase activity
D0Z67_RS00200	COG2271	Major facilitator Superfamily
D0Z67_RS00220	COG1132	(ABC) transporter
D0Z67_RS00225	COG0435	Glutathione S-transferase
D0Z67_RS00250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0Z67_RS00265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0Z67_RS00285	COG2814	Major facilitator Superfamily
D0Z67_RS00305	COG0477	Major facilitator Superfamily
D0Z67_RS00310	COG0667	Aldo Keto reductase
D0Z67_RS00325	COG0586	Pfam SNARE associated Golgi protein
D0Z67_RS00400	COG0673	inositol 2-dehydrogenase activity
D0Z67_RS00425	COG0009	L-threonylcarbamoyladenylate synthase
D0Z67_RS00430	COG0412	Dienelactone hydrolase
D0Z67_RS00445	COG4585	Histidine kinase
D0Z67_RS00450	COG2197	response regulator
D0Z67_RS00510	COG0366	Alpha amylase catalytic
D0Z67_RS00520	COG3281	Trehalose synthase
D0Z67_RS00525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0Z67_RS00540	COG1252	NADH dehydrogenase
D0Z67_RS00570	COG0477	Major facilitator Superfamily
D0Z67_RS00615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Z67_RS00625	COG0492	ferredoxin-NADP+ reductase activity
D0Z67_RS00675	COG3647	Membrane
D0Z67_RS00690	COG0583	DNA-binding transcription factor activity
D0Z67_RS00700	COG0477	Major facilitator Superfamily
D0Z67_RS00710	COG0328	RNA-DNA hybrid ribonuclease activity
D0Z67_RS00730	COG1191	sigma factor activity
D0Z67_RS00745	COG0667	Aldo Keto reductase
D0Z67_RS00750	COG0583	DNA-binding transcription factor activity
D0Z67_RS00760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Z67_RS00765	COG0346	lactoylglutathione lyase activity
D0Z67_RS00770	COG0667	Aldo Keto reductase
D0Z67_RS00780	COG0702	epimerase
D0Z67_RS00800	COG3250	beta-galactosidase activity
D0Z67_RS00845	COG0510	thiamine kinase activity
D0Z67_RS00875	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS00995	COG2986	histidine ammonia-lyase
D0Z67_RS01005	COG0477	Major facilitator Superfamily
D0Z67_RS01015	COG0784	Response regulator, receiver
D0Z67_RS01020	COG4251	negative regulation of phosphorylation
D0Z67_RS01025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Z67_RS01040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Z67_RS01045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0Z67_RS01065	COG1846	Transcriptional regulator
D0Z67_RS01095	COG1285	pathogenesis
D0Z67_RS01110	COG0673	inositol 2-dehydrogenase activity
D0Z67_RS01120	COG2211	Major facilitator Superfamily
D0Z67_RS01130	COG3469	chitinase activity
D0Z67_RS01150	COG2814	Major facilitator Superfamily
D0Z67_RS01160	COG0151	Belongs to the GarS family
D0Z67_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS01315	COG2205	protein histidine kinase activity
D0Z67_RS01320	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS01325	COG0671	phosphoesterase, PA-phosphatase related
D0Z67_RS01330	COG0586	Pfam SNARE associated Golgi protein
D0Z67_RS01335	COG5002	protein histidine kinase activity
D0Z67_RS01345	COG4181	ATPase activity
D0Z67_RS01350	COG1136	(ABC) transporter
D0Z67_RS01360	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS01365	COG0671	phosphoesterase, PA-phosphatase related
D0Z67_RS01425	COG4585	Histidine kinase
D0Z67_RS01435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0Z67_RS01445	COG2376	Dihydroxyacetone kinase
D0Z67_RS01450	COG1461	Dihydroxyacetone kinase
D0Z67_RS01455	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D0Z67_RS01480	COG1902	pentaerythritol trinitrate reductase activity
D0Z67_RS01480	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Z67_RS01500	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Z67_RS01515	COG0456	acetyltransferase
D0Z67_RS01515	COG0454	-acetyltransferase
D0Z67_RS01520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0Z67_RS01535	COG2226	methyltransferase
D0Z67_RS01540	COG2267	carboxylic ester hydrolase activity
D0Z67_RS01550	COG1686	Belongs to the peptidase S11 family
D0Z67_RS01560	COG2186	Transcriptional regulator
D0Z67_RS01565	COG1968	undecaprenyl-diphosphatase activity
D0Z67_RS01595	COG5398	heme oxygenase
D0Z67_RS01605	COG2814	Major facilitator Superfamily
D0Z67_RS01615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Z67_RS01630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Z67_RS01735	COG2267	carboxylic ester hydrolase activity
D0Z67_RS01750	COG0477	Major facilitator Superfamily
D0Z67_RS01755	COG0583	DNA-binding transcription factor activity
D0Z67_RS01770	COG0702	epimerase
D0Z67_RS01775	COG0667	Aldo Keto reductase
D0Z67_RS01780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0Z67_RS01810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Z67_RS01840	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D0Z67_RS01850	COG0287	Prephenate dehydrogenase
D0Z67_RS01855	COG0512	Glutamine amidotransferase of anthranilate synthase
D0Z67_RS01855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0Z67_RS01860	COG1605	Chorismate mutase
D0Z67_RS01870	COG0783	Belongs to the Dps family
D0Z67_RS01875	COG3046	protein related to deoxyribodipyrimidine photolyase
D0Z67_RS01950	COG0702	epimerase
D0Z67_RS01985	COG1609	Transcriptional regulator
D0Z67_RS02000	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS02005	COG1129	ABC transporter
D0Z67_RS02010	COG3250	beta-galactosidase activity
D0Z67_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS02020	COG3347	Dehydrogenase
D0Z67_RS02025	COG1070	Carbohydrate kinase
D0Z67_RS02050	COG1609	Transcriptional regulator
D0Z67_RS02060	COG2814	Major facilitator Superfamily
D0Z67_RS02080	COG0596	Alpha beta hydrolase
D0Z67_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS02125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0Z67_RS02130	COG1215	transferase activity, transferring glycosyl groups
D0Z67_RS02185	COG1940	carbohydrate kinase activity
D0Z67_RS02195	COG2813	Specifically methylates the guanine in position
D0Z67_RS02205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Z67_RS02210	COG1349	DNA-binding transcription factor activity
D0Z67_RS02235	COG1660	Displays ATPase and GTPase activities
D0Z67_RS02245	COG3345	alpha-galactosidase
D0Z67_RS02270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D0Z67_RS02290	COG0204	Acyl-transferase
D0Z67_RS02310	COG0584	glycerophosphoryl diester phosphodiesterase
D0Z67_RS02345	COG0671	phosphoesterase, PA-phosphatase related
D0Z67_RS02350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Z67_RS02355	COG1309	transcriptional regulator
D0Z67_RS02360	COG0493	'glutamate synthase
D0Z67_RS02370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0Z67_RS02385	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS02400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0Z67_RS02425	COG0477	Major facilitator Superfamily
D0Z67_RS02440	COG2226	methyltransferase
D0Z67_RS02445	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D0Z67_RS02450	COG1408	metallophosphoesterase
D0Z67_RS02480	COG2957	Belongs to the agmatine deiminase family
D0Z67_RS02485	COG1309	transcriptional regulator
D0Z67_RS02490	COG0432	Pfam Uncharacterised protein family UPF0047
D0Z67_RS02495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z67_RS02500	COG1116	anion transmembrane transporter activity
D0Z67_RS02510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS02515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0Z67_RS02520	COG1132	(ABC) transporter
D0Z67_RS02535	COG1132	(ABC) transporter
D0Z67_RS02545	COG0254	rRNA binding
D0Z67_RS02560	COG1946	Acyl-CoA thioesterase
D0Z67_RS02570	COG2018	Roadblock/LC7 domain
D0Z67_RS02625	COG2115	Belongs to the xylose isomerase family
D0Z67_RS02635	COG1846	Transcriptional regulator
D0Z67_RS02635	COG1940	carbohydrate kinase activity
D0Z67_RS02650	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS02655	COG0671	phosphoesterase, PA-phosphatase related
D0Z67_RS02660	COG0586	Pfam SNARE associated Golgi protein
D0Z67_RS02700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0Z67_RS02720	COG3415	Transposase
D0Z67_RS02720	COG2801	Transposase and inactivated derivatives
D0Z67_RS02750	COG3537	Alpha-1,2-mannosidase
D0Z67_RS02780	COG1222	aaa ATPase
D0Z67_RS02850	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS02865	COG0367	asparagine synthase
D0Z67_RS02875	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Z67_RS02930	COG2268	Band 7 protein
D0Z67_RS02950	COG0693	protein deglycase activity
D0Z67_RS02960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0Z67_RS02985	COG1278	Cold shock
D0Z67_RS02990	COG0513	Belongs to the DEAD box helicase family
D0Z67_RS02995	COG0784	Response regulator, receiver
D0Z67_RS03000	COG4251	negative regulation of phosphorylation
D0Z67_RS03015	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D0Z67_RS03020	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D0Z67_RS03025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D0Z67_RS03080	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS03085	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS03100	COG1793	dna ligase
D0Z67_RS03120	COG3424	synthase
D0Z67_RS03125	COG2124	cytochrome p450
D0Z67_RS03135	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS03145	COG0242	peptide deformylase activity
D0Z67_RS03155	COG3442	glutamine amidotransferase
D0Z67_RS03160	COG0205	6-phosphofructokinase activity
D0Z67_RS03170	COG1522	sequence-specific DNA binding
D0Z67_RS03175	COG1834	amidinotransferase
D0Z67_RS03180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Z67_RS03200	COG1271	oxidase subunit
D0Z67_RS03205	COG0204	Acyl-transferase
D0Z67_RS03215	COG0829	nickel cation binding
D0Z67_RS03220	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0Z67_RS03230	COG0804	urea catabolic process
D0Z67_RS03235	COG0832	Belongs to the urease beta subunit family
D0Z67_RS03240	COG0831	urea catabolic process
D0Z67_RS03250	COG0740	serine-type endopeptidase activity
D0Z67_RS03275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0Z67_RS03280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Z67_RS03285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0Z67_RS03295	COG0577	efflux transmembrane transporter activity
D0Z67_RS03295	COG1136	(ABC) transporter
D0Z67_RS03300	COG0577	efflux transmembrane transporter activity
D0Z67_RS03330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0Z67_RS03335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0Z67_RS03340	COG3663	DNA glycosylase
D0Z67_RS03360	COG4585	Histidine kinase
D0Z67_RS03365	COG2197	response regulator
D0Z67_RS03370	COG1940	carbohydrate kinase activity
D0Z67_RS03375	COG2188	Transcriptional regulator
D0Z67_RS03380	COG1595	DNA-templated transcription, initiation
D0Z67_RS03385	COG0596	Alpha beta hydrolase
D0Z67_RS03395	COG0626	cystathionine gamma-synthase activity
D0Z67_RS03425	COG2124	cytochrome p450
D0Z67_RS03430	COG0419	ATPase involved in DNA repair
D0Z67_RS03435	COG0420	3'-5' exonuclease activity
D0Z67_RS03440	COG1739	Uncharacterized protein family UPF0029
D0Z67_RS03455	COG1832	CoA-binding protein
D0Z67_RS03470	COG0110	maltose O-acetyltransferase activity
D0Z67_RS03520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0Z67_RS03530	COG1968	undecaprenyl-diphosphatase activity
D0Z67_RS03540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0Z67_RS03545	COG0673	inositol 2-dehydrogenase activity
D0Z67_RS03560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0Z67_RS03565	COG0747	negative chemotaxis
D0Z67_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS03620	COG0697	spore germination
D0Z67_RS03655	COG1695	Transcriptional regulator
D0Z67_RS03660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D0Z67_RS03670	COG2318	DinB family
D0Z67_RS03675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0Z67_RS03680	COG0384	phenazine biosynthesis protein PhzF
D0Z67_RS03725	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0Z67_RS03745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Z67_RS03745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Z67_RS03755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Z67_RS03775	COG1716	ATPase activity
D0Z67_RS03795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D0Z67_RS03830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0Z67_RS03845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z67_RS03850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0Z67_RS03880	COG2018	Roadblock/LC7 domain
D0Z67_RS03920	COG4638	Rieske (2fe-2S)
D0Z67_RS03925	COG0531	amino acid
D0Z67_RS03950	COG2814	Major facilitator Superfamily
D0Z67_RS03955	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D0Z67_RS03960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0Z67_RS03965	COG1984	allophanate hydrolase subunit 2
D0Z67_RS04010	COG2270	Major facilitator Superfamily
D0Z67_RS04025	COG1216	Glycosyl transferase, family 2
D0Z67_RS04050	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS04100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0Z67_RS04105	COG0140	phosphoribosyl-ATP diphosphatase activity
D0Z67_RS04110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D0Z67_RS04115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0Z67_RS04115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0Z67_RS04120	COG3201	nicotinamide mononucleotide transporter
D0Z67_RS04135	COG1940	carbohydrate kinase activity
D0Z67_RS04135	COG1846	Transcriptional regulator
D0Z67_RS04140	COG0738	Major facilitator superfamily
D0Z67_RS04150	COG2233	PERMEase
D0Z67_RS04170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Z67_RS04210	COG2390	Transcriptional regulator
D0Z67_RS04215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0Z67_RS04225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Z67_RS04240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0Z67_RS04255	COG0194	GDP metabolic process
D0Z67_RS04265	COG0284	orotidine-5'-phosphate decarboxylase activity
D0Z67_RS04270	COG0167	dihydroorotate dehydrogenase activity
D0Z67_RS04275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0Z67_RS04280	COG0505	Belongs to the CarA family
D0Z67_RS04290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0Z67_RS04295	COG0540	Belongs to the ATCase OTCase family
D0Z67_RS04300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D0Z67_RS04310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Z67_RS04315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0Z67_RS04320	COG0006	proline dipeptidase activity
D0Z67_RS04330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D0Z67_RS04335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0Z67_RS04340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0Z67_RS04345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0Z67_RS04350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0Z67_RS04355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0Z67_RS04360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0Z67_RS04375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D0Z67_RS04390	COG0124	histidyl-tRNA synthetase
D0Z67_RS04400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0Z67_RS04405	COG1196	nuclear chromosome segregation
D0Z67_RS04410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Z67_RS04420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0Z67_RS04425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0Z67_RS04430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0Z67_RS04440	COG1862	Preprotein translocase
D0Z67_RS04445	COG2255	four-way junction helicase activity
D0Z67_RS04450	COG0632	four-way junction helicase activity
D0Z67_RS04455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D0Z67_RS04460	COG0217	transcriptional regulatory protein
D0Z67_RS04465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D0Z67_RS04470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D0Z67_RS04480	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS04485	COG1560	Kdo2-lipid A biosynthetic process
D0Z67_RS04490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0Z67_RS04510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0Z67_RS04515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0Z67_RS04530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0Z67_RS04580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0Z67_RS04630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Z67_RS04635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0Z67_RS04635	COG1648	precorrin-2 dehydrogenase activity
D0Z67_RS04640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D0Z67_RS04660	COG1464	Belongs to the NlpA lipoprotein family
D0Z67_RS04665	COG2011	ABC-type metal ion transport system permease component
D0Z67_RS04670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0Z67_RS04695	COG0584	glycerophosphoryl diester phosphodiesterase
D0Z67_RS04705	COG0477	Major facilitator Superfamily
D0Z67_RS04720	COG0165	Argininosuccinate lyase
D0Z67_RS04725	COG0137	argininosuccinate synthase activity
D0Z67_RS04755	COG1438	arginine binding
D0Z67_RS04760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Z67_RS04765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0Z67_RS04770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D0Z67_RS04775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0Z67_RS04795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D0Z67_RS04800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Z67_RS04810	COG2207	Transcriptional regulator
D0Z67_RS04810	COG3708	Transcriptional regulator
D0Z67_RS04835	COG0697	spore germination
D0Z67_RS04845	COG1649	PFAM Uncharacterised BCR, COG1649
D0Z67_RS04870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Z67_RS04870	COG0072	phenylalanine-tRNA ligase activity
D0Z67_RS04875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0Z67_RS04880	COG5002	protein histidine kinase activity
D0Z67_RS04885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Z67_RS04890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D0Z67_RS04895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0Z67_RS04900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D0Z67_RS04940	COG0560	Phosphoserine phosphatase
D0Z67_RS04940	COG3830	Belongs to the UPF0237 family
D0Z67_RS04950	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS04955	COG0174	glutamine synthetase
D0Z67_RS04965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D0Z67_RS04990	COG4176	ABC-type proline glycine betaine transport system permease component
D0Z67_RS05000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0Z67_RS05015	COG0564	pseudouridine synthase activity
D0Z67_RS05050	COG0805	protein transport
D0Z67_RS05055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Z67_RS05075	COG2378	regulation of single-species biofilm formation
D0Z67_RS05090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D0Z67_RS05100	COG1609	Transcriptional regulator
D0Z67_RS05105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D0Z67_RS05110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D0Z67_RS05125	COG4122	O-methyltransferase activity
D0Z67_RS05130	COG1222	aaa ATPase
D0Z67_RS05155	COG0517	IMP dehydrogenase activity
D0Z67_RS05155	COG1994	Peptidase M50
D0Z67_RS05165	COG2197	response regulator
D0Z67_RS05175	COG0747	negative chemotaxis
D0Z67_RS05185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Z67_RS05190	COG0646	methionine synthase
D0Z67_RS05190	COG1410	methionine synthase
D0Z67_RS05195	COG1414	Transcriptional regulator
D0Z67_RS05200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Z67_RS05205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0Z67_RS05210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0Z67_RS05225	COG0215	cysteine-tRNA ligase activity
D0Z67_RS05245	COG0598	Magnesium transport protein CorA
D0Z67_RS05255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS05260	COG0667	Aldo Keto reductase
D0Z67_RS05290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Z67_RS05300	COG3012	SEC-C Motif Domain Protein
D0Z67_RS05305	COG2186	Transcriptional regulator
D0Z67_RS05310	COG3265	gluconokinase activity
D0Z67_RS05320	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS05345	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D0Z67_RS05350	COG2149	membrane
D0Z67_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS05385	COG3876	Protein conserved in bacteria
D0Z67_RS05405	COG0789	Transcriptional regulator
D0Z67_RS05425	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS05435	COG0640	Transcriptional regulator
D0Z67_RS05450	COG0243	molybdopterin cofactor binding
D0Z67_RS05455	COG1309	transcriptional regulator
D0Z67_RS05460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0Z67_RS05465	COG2188	Transcriptional regulator
D0Z67_RS05475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z67_RS05490	COG1595	DNA-templated transcription, initiation
D0Z67_RS05510	COG0515	serine threonine protein kinase
D0Z67_RS05510	COG2815	serine threonine protein kinase
D0Z67_RS05515	COG2755	lipolytic protein G-D-S-L family
D0Z67_RS05535	COG0726	polysaccharide deacetylase
D0Z67_RS05560	COG1725	Transcriptional regulator
D0Z67_RS05580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0Z67_RS05580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0Z67_RS05595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Z67_RS05600	COG0587	DNA-directed DNA polymerase activity
D0Z67_RS05615	COG1799	cell septum assembly
D0Z67_RS05620	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS05625	COG0477	Major facilitator Superfamily
D0Z67_RS05635	COG0671	phosphoesterase, PA-phosphatase related
D0Z67_RS05645	COG1652	LysM domain
D0Z67_RS05660	COG1160	GTP binding
D0Z67_RS05670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0Z67_RS05695	COG1187	pseudouridine synthase activity
D0Z67_RS05700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D0Z67_RS05705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D0Z67_RS05720	COG0686	Belongs to the AlaDH PNT family
D0Z67_RS05730	COG0494	nUDIX hydrolase
D0Z67_RS05735	COG0504	CTP synthase activity
D0Z67_RS05740	COG3387	PFAM Glycoside hydrolase 15-related
D0Z67_RS05755	COG0297	glycogen (starch) synthase activity
D0Z67_RS05765	COG0497	DNA recombination
D0Z67_RS05770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0Z67_RS05790	COG1120	ATPase activity
D0Z67_RS05795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Z67_RS05800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Z67_RS05805	COG0647	UMP catabolic process
D0Z67_RS05850	COG2094	Belongs to the DNA glycosylase MPG family
D0Z67_RS05860	COG1881	PFAM PEBP family protein
D0Z67_RS05880	COG1119	ATPase activity
D0Z67_RS05890	COG2197	response regulator
D0Z67_RS05895	COG4585	Histidine kinase
D0Z67_RS05905	COG1716	ATPase activity
D0Z67_RS05905	COG0842	Transport permease protein
D0Z67_RS05905	COG1131	(ABC) transporter
D0Z67_RS05910	COG3830	Belongs to the UPF0237 family
D0Z67_RS05910	COG0560	Phosphoserine phosphatase
D0Z67_RS05930	COG2186	Transcriptional regulator
D0Z67_RS05950	COG1122	ATPase activity
D0Z67_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS05985	COG0181	hydroxymethylbilane synthase activity
D0Z67_RS06000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0Z67_RS06020	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0Z67_RS06025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Z67_RS06035	COG1404	Belongs to the peptidase S8 family
D0Z67_RS06040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z67_RS06045	COG1063	alcohol dehydrogenase
D0Z67_RS06050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0Z67_RS06065	COG3387	PFAM Glycoside hydrolase 15-related
D0Z67_RS06105	COG1024	Enoyl-CoA hydratase
D0Z67_RS06115	COG0488	(ABC) transporter
D0Z67_RS06135	COG0235	Class ii aldolase
D0Z67_RS06155	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D0Z67_RS06160	COG1492	cobalamin metabolic process
D0Z67_RS06180	COG1797	cobyrinic acid a,c-diamide synthase activity
D0Z67_RS06215	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D0Z67_RS06240	COG0765	amino acid transport
D0Z67_RS06245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z67_RS06250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0Z67_RS06255	COG0456	acetyltransferase
D0Z67_RS06260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0Z67_RS06265	COG1917	Cupin 2, conserved barrel domain protein
D0Z67_RS06270	COG5285	phytanoyl-CoA dioxygenase
D0Z67_RS06275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0Z67_RS06300	COG1414	Transcriptional regulator
D0Z67_RS06305	COG0768	penicillin binding
D0Z67_RS06325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Z67_RS06330	COG1349	DNA-binding transcription factor activity
D0Z67_RS06350	COG1063	alcohol dehydrogenase
D0Z67_RS06365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Z67_RS06385	COG1309	transcriptional regulator
D0Z67_RS06395	COG2171	N-acyltransferase activity
D0Z67_RS06405	COG0822	iron-sulfur transferase activity
D0Z67_RS06410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0Z67_RS06415	COG0396	ATPase activity
D0Z67_RS06425	COG0719	Fe-S assembly protein
D0Z67_RS06440	COG2746	aminoglycoside 3-N-acetyltransferase activity
D0Z67_RS06445	COG1131	(ABC) transporter
D0Z67_RS06455	COG1612	heme a metabolic process
D0Z67_RS06470	COG0109	protoheme IX farnesyltransferase activity
D0Z67_RS06485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0Z67_RS06500	COG0363	glucosamine-6-phosphate deaminase activity
D0Z67_RS06510	COG0166	Belongs to the GPI family
D0Z67_RS06525	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0Z67_RS06530	COG0149	triose-phosphate isomerase activity
D0Z67_RS06535	COG0126	phosphoglycerate kinase activity
D0Z67_RS06540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0Z67_RS06550	COG1481	regulation of sporulation
D0Z67_RS06555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0Z67_RS06560	COG1660	Displays ATPase and GTPase activities
D0Z67_RS06565	COG0322	excinuclease ABC activity
D0Z67_RS06580	COG1609	Transcriptional regulator
D0Z67_RS06590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Z67_RS06600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Z67_RS06605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0Z67_RS06610	COG0387	Pfam Sodium calcium exchanger
D0Z67_RS06630	COG0556	nucleotide-excision repair
D0Z67_RS06640	COG0584	glycerophosphoryl diester phosphodiesterase
D0Z67_RS06645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Z67_RS06650	COG2313	pseudouridylate synthase activity
D0Z67_RS06655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0Z67_RS06655	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D0Z67_RS06660	COG2226	methyltransferase
D0Z67_RS06665	COG0598	Magnesium transport protein CorA
D0Z67_RS06745	COG1288	antiporter activity
D0Z67_RS06755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Z67_RS06770	COG0237	dephospho-CoA kinase activity
D0Z67_RS06790	COG1643	Atp-dependent helicase
D0Z67_RS06820	COG2050	protein possibly involved in aromatic compounds catabolism
D0Z67_RS06835	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS06875	COG2968	Membrane
D0Z67_RS06880	COG0737	Belongs to the 5'-nucleotidase family
D0Z67_RS06890	COG0076	glutamate decarboxylase activity
D0Z67_RS06905	COG1605	Chorismate mutase
D0Z67_RS06905	COG0287	Prephenate dehydrogenase
D0Z67_RS06930	COG0069	glutamate synthase activity
D0Z67_RS06930	COG0067	glutamate synthase
D0Z67_RS06930	COG0070	glutamate synthase
D0Z67_RS06950	COG1397	ADP-ribosylglycohydrolase
D0Z67_RS06960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z67_RS06965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z67_RS06975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0Z67_RS06985	COG0159	tryptophan synthase activity
D0Z67_RS06990	COG0133	tryptophan synthase activity
D0Z67_RS07000	COG0134	indole-3-glycerol-phosphate synthase activity
D0Z67_RS07020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0Z67_RS07025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0Z67_RS07045	COG0107	imidazoleglycerol-phosphate synthase activity
D0Z67_RS07050	COG0251	oxidation-reduction process
D0Z67_RS07055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0Z67_RS07060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0Z67_RS07065	COG0131	Imidazoleglycerol-phosphate dehydratase
D0Z67_RS07070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Z67_RS07075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0Z67_RS07095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0Z67_RS07115	COG1432	Conserved Protein
D0Z67_RS07120	COG0587	DNA-directed DNA polymerase activity
D0Z67_RS07145	COG3415	Transposase
D0Z67_RS07145	COG2801	Transposase and inactivated derivatives
D0Z67_RS07165	COG2153	protein acetylation
D0Z67_RS07175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D0Z67_RS07185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0Z67_RS07190	COG3599	regulation of cell shape
D0Z67_RS07200	COG1799	cell septum assembly
D0Z67_RS07210	COG1496	oxidoreductase activity
D0Z67_RS07215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0Z67_RS07220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0Z67_RS07230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0Z67_RS07240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0Z67_RS07245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0Z67_RS07255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0Z67_RS07270	COG0275	rRNA processing
D0Z67_RS07280	COG0714	Associated with various cellular activities
D0Z67_RS07300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Z67_RS07310	COG1129	ABC transporter
D0Z67_RS07320	COG1309	transcriptional regulator
D0Z67_RS07325	COG1233	COG1233 Phytoene dehydrogenase and related
D0Z67_RS07340	COG0352	thiamine-phosphate diphosphorylase activity
D0Z67_RS07360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z67_RS07360	COG2022	thiamine diphosphate biosynthetic process
D0Z67_RS07375	COG0515	serine threonine protein kinase
D0Z67_RS07375	COG2815	serine threonine protein kinase
D0Z67_RS07380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D0Z67_RS07385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0Z67_RS07390	COG2193	ferroxidase activity
D0Z67_RS07400	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D0Z67_RS07415	COG0205	6-phosphofructokinase activity
D0Z67_RS07440	COG4585	Histidine kinase
D0Z67_RS07465	COG1940	carbohydrate kinase activity
D0Z67_RS07475	COG0003	Pfam Anion-transporting ATPase
D0Z67_RS07495	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS07510	COG3883	PFAM NLP P60 protein
D0Z67_RS07510	COG0791	NLP P60 protein
D0Z67_RS07540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0Z67_RS07545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Z67_RS07550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0Z67_RS07555	COG0723	plastoquinol--plastocyanin reductase activity
D0Z67_RS07560	COG2010	Cytochrome c
D0Z67_RS07565	COG1845	cytochrome c oxidase, subunit III
D0Z67_RS07575	COG1376	ErfK ybiS ycfS ynhG family protein
D0Z67_RS07585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Z67_RS07590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0Z67_RS07600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z67_RS07625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D0Z67_RS07630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Z67_RS07635	COG2197	response regulator
D0Z67_RS07665	COG2226	methyltransferase
D0Z67_RS07670	COG2197	response regulator
D0Z67_RS07675	COG3851	Histidine kinase
D0Z67_RS07685	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0Z67_RS07685	COG1136	(ABC) transporter
D0Z67_RS07690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Z67_RS07705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Z67_RS07710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D0Z67_RS07715	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D0Z67_RS07715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0Z67_RS07730	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D0Z67_RS07735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0Z67_RS07740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Z67_RS07745	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Z67_RS07755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0Z67_RS07770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Z67_RS07790	COG0321	lipoyl(octanoyl) transferase activity
D0Z67_RS07795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0Z67_RS07815	COG0174	glutamine synthetase
D0Z67_RS07850	COG0501	Belongs to the peptidase M48B family
D0Z67_RS07890	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS07945	COG0366	Alpha amylase catalytic
D0Z67_RS07950	COG3833	ABC-type maltose transport systems, permease component
D0Z67_RS07955	COG1175	transmembrane transport
D0Z67_RS07965	COG1609	Transcriptional regulator
D0Z67_RS07975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0Z67_RS07990	COG0174	glutamine synthetase
D0Z67_RS08010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Z67_RS08010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0Z67_RS08025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z67_RS08040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D0Z67_RS08045	COG0477	Major facilitator Superfamily
D0Z67_RS08060	COG2814	Major facilitator Superfamily
D0Z67_RS08095	COG1994	Peptidase M50
D0Z67_RS08135	COG2837	iron assimilation
D0Z67_RS08160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0Z67_RS08165	COG2814	Major facilitator Superfamily
D0Z67_RS08170	COG1686	Belongs to the peptidase S11 family
D0Z67_RS08180	COG2259	Doxx family
D0Z67_RS08190	COG3022	response to hydroperoxide
D0Z67_RS08195	COG0800	Aldolase
D0Z67_RS08210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0Z67_RS08225	COG4585	Histidine kinase
D0Z67_RS08230	COG2197	response regulator
D0Z67_RS08235	COG0477	Major facilitator Superfamily
D0Z67_RS08245	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0Z67_RS08245	COG2247	cell wall binding repeat
D0Z67_RS08295	COG3845	ABC transporter
D0Z67_RS08310	COG3619	membrane
D0Z67_RS08330	COG4122	O-methyltransferase activity
D0Z67_RS08355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Z67_RS08390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0Z67_RS08425	COG1358	cellular component organization or biogenesis
D0Z67_RS08470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0Z67_RS08475	COG0477	Major facilitator Superfamily
D0Z67_RS08480	COG1309	transcriptional regulator
D0Z67_RS08495	COG0667	Aldo Keto reductase
D0Z67_RS08500	COG0789	Transcriptional regulator
D0Z67_RS08515	COG1741	Belongs to the pirin family
D0Z67_RS08530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Z67_RS08535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Z67_RS08540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Z67_RS08570	COG2130	NADP-dependent
D0Z67_RS08585	COG4948	Mandelate Racemase Muconate Lactonizing
D0Z67_RS08610	COG4214	carbohydrate transport
D0Z67_RS08615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Z67_RS08645	COG1414	Transcriptional regulator
D0Z67_RS08665	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS08670	COG1077	Cell shape determining protein MreB Mrl
D0Z67_RS08710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Z67_RS08725	COG3511	phospholipase C
D0Z67_RS08765	COG1070	Carbohydrate kinase
D0Z67_RS08780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Z67_RS08785	COG0358	DNA primase activity
D0Z67_RS08795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D0Z67_RS08800	COG2949	membrane
D0Z67_RS08820	COG0395	ABC-type sugar transport system, permease component
D0Z67_RS08825	COG1175	transmembrane transport
D0Z67_RS08830	COG2182	Extracellular solute-binding protein
D0Z67_RS08840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0Z67_RS08840	COG0574	Belongs to the PEP-utilizing enzyme family
D0Z67_RS08845	COG1846	Transcriptional regulator
D0Z67_RS08845	COG1940	carbohydrate kinase activity
D0Z67_RS08850	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0Z67_RS08885	COG0477	Major facilitator Superfamily
D0Z67_RS08905	COG0667	Aldo Keto reductase
D0Z67_RS08910	COG0423	glycine-tRNA ligase activity
D0Z67_RS08915	COG3443	Belongs to the bacterial solute-binding protein 9 family
D0Z67_RS08915	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0Z67_RS08920	COG1121	(ABC) transporter
D0Z67_RS08925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0Z67_RS08940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0Z67_RS08945	COG1381	Involved in DNA repair and RecF pathway recombination
D0Z67_RS09020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0Z67_RS09045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0Z67_RS09075	COG2315	Protein conserved in bacteria
D0Z67_RS09085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0Z67_RS09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z67_RS09100	COG4948	Mandelate Racemase Muconate Lactonizing
D0Z67_RS09105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Z67_RS09115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Z67_RS09120	COG1234	tRNA 3'-trailer cleavage
D0Z67_RS09125	COG0537	adenosine 5'-monophosphoramidase activity
D0Z67_RS09130	COG0793	Belongs to the peptidase S41A family
D0Z67_RS09130	COG4946	Tricorn protease homolog
D0Z67_RS09155	COG0484	heat shock protein binding
D0Z67_RS09160	COG1420	regulation of RNA biosynthetic process
D0Z67_RS09195	COG0481	GTPase activity
D0Z67_RS09200	COG0268	Binds directly to 16S ribosomal RNA
D0Z67_RS09225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Z67_RS09235	COG1555	photosystem II stabilization
D0Z67_RS09240	COG1307	EDD domain protein, DegV family
D0Z67_RS09250	COG0495	leucyl-tRNA aminoacylation
D0Z67_RS09265	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D0Z67_RS09285	COG0588	phosphoglycerate mutase activity
D0Z67_RS09300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0Z67_RS09310	COG0501	Belongs to the peptidase M48B family
D0Z67_RS09325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0Z67_RS09335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0Z67_RS09350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0Z67_RS09355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0Z67_RS09360	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS09365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0Z67_RS09370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D0Z67_RS09375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0Z67_RS09390	COG1530	ribonuclease E activity
D0Z67_RS09415	COG3152	Membrane
D0Z67_RS09430	COG0772	Belongs to the SEDS family
D0Z67_RS09435	COG0768	penicillin binding
D0Z67_RS09450	COG1077	Cell shape determining protein MreB Mrl
D0Z67_RS09455	COG0105	UTP biosynthetic process
D0Z67_RS09465	COG0285	dihydrofolate synthase activity
D0Z67_RS09470	COG0525	valine-tRNA ligase activity
D0Z67_RS09480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0Z67_RS09485	COG0740	serine-type endopeptidase activity
D0Z67_RS09490	COG0740	serine-type endopeptidase activity
D0Z67_RS09495	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0Z67_RS09515	COG3594	Acyltransferase
D0Z67_RS09540	COG1113	amino acid transport
D0Z67_RS09555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0Z67_RS09560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D0Z67_RS09610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Z67_RS09630	COG1595	DNA-templated transcription, initiation
D0Z67_RS09640	COG1131	(ABC) transporter
D0Z67_RS09660	COG0668	transmembrane transport
D0Z67_RS09665	COG1486	melibiose metabolic process
D0Z67_RS09680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z67_RS09710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D0Z67_RS09715	COG2346	COG2346, Truncated hemoglobins
D0Z67_RS09770	COG0629	single-stranded DNA binding
D0Z67_RS09775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0Z67_RS09840	COG1609	Transcriptional regulator
D0Z67_RS09955	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS09960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Z67_RS09980	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS10045	COG3962	Belongs to the TPP enzyme family
D0Z67_RS10050	COG3718	enzyme involved in inositol metabolism
D0Z67_RS10060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z67_RS10090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0Z67_RS10100	COG1129	ABC transporter
D0Z67_RS10105	COG1879	ABC-type sugar transport system periplasmic component
D0Z67_RS10110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z67_RS10115	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Z67_RS10150	COG2356	endonuclease I
D0Z67_RS10155	COG0028	Belongs to the TPP enzyme family
D0Z67_RS10165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Z67_RS10185	COG1946	Acyl-CoA thioesterase
D0Z67_RS10200	COG1309	transcriptional regulator
D0Z67_RS10205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Z67_RS10220	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS10240	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D0Z67_RS10270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Z67_RS10285	COG4977	sequence-specific DNA binding
D0Z67_RS10290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D0Z67_RS10335	COG3979	chitinase
D0Z67_RS10340	COG2205	protein histidine kinase activity
D0Z67_RS10345	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS10355	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D0Z67_RS10370	COG0406	alpha-ribazole phosphatase activity
D0Z67_RS10420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS10430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Z67_RS10435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z67_RS10440	COG0765	amino acid transport
D0Z67_RS10445	COG0765	amino acid transport
D0Z67_RS10450	COG1126	abc transporter atp-binding protein
D0Z67_RS10465	COG3397	chitin binding
D0Z67_RS10525	COG0673	inositol 2-dehydrogenase activity
D0Z67_RS10530	COG4702	Belongs to the UPF0303 family
D0Z67_RS10575	COG0667	Aldo Keto reductase
D0Z67_RS10585	COG0477	Major facilitator Superfamily
D0Z67_RS10590	COG2733	membrane
D0Z67_RS10600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0Z67_RS10625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Z67_RS10640	COG4555	ABC transporter
D0Z67_RS10655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0Z67_RS10660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Z67_RS10665	COG1263	PTS System
D0Z67_RS10670	COG1234	tRNA 3'-trailer cleavage
D0Z67_RS10700	COG1113	amino acid transport
D0Z67_RS10710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D0Z67_RS10720	COG1335	isochorismatase
D0Z67_RS10755	COG0277	FAD linked oxidase domain protein
D0Z67_RS10765	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D0Z67_RS10775	COG3480	Lon protease (S16) C-terminal proteolytic domain
D0Z67_RS10805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0Z67_RS10820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D0Z67_RS10830	COG1678	Uncharacterized ACR, COG1678
D0Z67_RS10835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0Z67_RS10840	COG0776	regulation of translation
D0Z67_RS10850	COG3973	AAA domain
D0Z67_RS10885	COG0583	DNA-binding transcription factor activity
D0Z67_RS10900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0Z67_RS10905	COG0793	Belongs to the peptidase S41A family
D0Z67_RS10910	COG2177	Part of the ABC transporter FtsEX involved in
D0Z67_RS10915	COG2884	Cell division ATP-binding protein ftsE
D0Z67_RS10930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D0Z67_RS10935	COG0515	serine threonine protein kinase
D0Z67_RS10940	COG0515	serine threonine protein kinase
D0Z67_RS10945	COG1674	ftsk spoiiie
D0Z67_RS10955	COG1175	transmembrane transport
D0Z67_RS10960	COG0395	ABC-type sugar transport system, permease component
D0Z67_RS10970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0Z67_RS10975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0Z67_RS10975	COG0463	Glycosyl transferase, family 2
D0Z67_RS10980	COG1764	response to oxidative stress
D0Z67_RS10985	COG1846	Transcriptional regulator
D0Z67_RS11005	COG1309	transcriptional regulator
D0Z67_RS11015	COG1134	teichoic acid transport
D0Z67_RS11020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0Z67_RS11025	COG1215	transferase activity, transferring glycosyl groups
D0Z67_RS11035	COG2902	Dehydrogenase
D0Z67_RS11055	COG0653	protein targeting
D0Z67_RS11065	COG3214	Protein conserved in bacteria
D0Z67_RS11070	COG2197	response regulator
D0Z67_RS11075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0Z67_RS11090	COG0823	Involved in the tonB-independent uptake of proteins
D0Z67_RS11095	COG5002	protein histidine kinase activity
D0Z67_RS11095	COG5000	phosphorelay sensor kinase activity
D0Z67_RS11100	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS11105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D0Z67_RS11125	COG0714	Associated with various cellular activities
D0Z67_RS11170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D0Z67_RS11180	COG1482	cell wall glycoprotein biosynthetic process
D0Z67_RS11190	COG2835	tetraacyldisaccharide 4'-kinase activity
D0Z67_RS11235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0Z67_RS11240	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D0Z67_RS11240	COG0778	Nitroreductase
D0Z67_RS11260	COG1316	TRANSCRIPTIONal
D0Z67_RS11265	COG1316	TRANSCRIPTIONal
D0Z67_RS11270	COG1316	TRANSCRIPTIONal
D0Z67_RS11280	COG1316	TRANSCRIPTIONal
D0Z67_RS11290	COG1316	TRANSCRIPTIONal
D0Z67_RS11300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D0Z67_RS11330	COG1902	pentaerythritol trinitrate reductase activity
D0Z67_RS11355	COG2205	protein histidine kinase activity
D0Z67_RS11360	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS11365	COG3104	oligopeptide transport
D0Z67_RS11380	COG1366	Belongs to the anti-sigma-factor antagonist family
D0Z67_RS11385	COG1191	sigma factor activity
D0Z67_RS11390	COG1228	amidohydrolase
D0Z67_RS11405	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D0Z67_RS11445	COG1280	lysine exporter protein (LysE YggA)
D0Z67_RS11455	COG2755	lipolytic protein G-D-S-L family
D0Z67_RS11460	COG0183	Belongs to the thiolase family
D0Z67_RS11520	COG1136	(ABC) transporter
D0Z67_RS11525	COG0577	efflux transmembrane transporter activity
D0Z67_RS11530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Z67_RS11535	COG1252	NADH dehydrogenase
D0Z67_RS11555	COG0148	phosphopyruvate hydratase activity
D0Z67_RS11565	COG1652	LysM domain
D0Z67_RS11570	COG2124	cytochrome p450
D0Z67_RS11635	COG0577	efflux transmembrane transporter activity
D0Z67_RS11640	COG1136	(ABC) transporter
D0Z67_RS11670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D0Z67_RS11675	COG1335	isochorismatase
D0Z67_RS11680	COG0473	3-isopropylmalate dehydrogenase activity
D0Z67_RS11690	COG4585	Histidine kinase
D0Z67_RS11705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0Z67_RS11710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0Z67_RS11715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D0Z67_RS11720	COG0193	aminoacyl-tRNA hydrolase activity
D0Z67_RS11730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0Z67_RS11740	COG1309	transcriptional regulator
D0Z67_RS11750	COG4106	trans-aconitate 2-methyltransferase activity
D0Z67_RS11760	COG2197	response regulator
D0Z67_RS11770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0Z67_RS11810	COG0488	(ABC) transporter
D0Z67_RS11820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0Z67_RS11825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0Z67_RS11830	COG3583	domain protein
D0Z67_RS11830	COG3584	3D domain protein
D0Z67_RS11835	COG0084	hydrolase, TatD family'
D0Z67_RS11855	COG0768	penicillin binding
D0Z67_RS11860	COG0768	penicillin binding
D0Z67_RS11870	COG0310	cobalt ion transport
D0Z67_RS11880	COG1122	ATPase activity
D0Z67_RS11910	COG2409	Drug exporters of the RND superfamily
D0Z67_RS11920	COG0793	Belongs to the peptidase S41A family
D0Z67_RS11920	COG4946	Tricorn protease homolog
D0Z67_RS11925	COG3973	AAA domain
D0Z67_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS11945	COG2072	flavoprotein involved in K transport
D0Z67_RS11955	COG0708	Exodeoxyribonuclease III
D0Z67_RS11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Z67_RS11990	COG0315	cyclic pyranopterin monophosphate synthase activity
D0Z67_RS11990	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0Z67_RS11995	COG0315	cyclic pyranopterin monophosphate synthase activity
D0Z67_RS12005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0Z67_RS12010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0Z67_RS12015	COG2366	antibiotic biosynthetic process
D0Z67_RS12035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D0Z67_RS12045	COG1970	mechanosensitive ion channel activity
D0Z67_RS12050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0Z67_RS12060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Z67_RS12060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Z67_RS12060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Z67_RS12070	COG1349	DNA-binding transcription factor activity
D0Z67_RS12075	COG0477	Major facilitator Superfamily
D0Z67_RS12090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Z67_RS12095	COG1247	-acetyltransferase
D0Z67_RS12100	COG3384	dioxygenase
D0Z67_RS12105	COG1846	Transcriptional regulator
D0Z67_RS12115	COG1309	transcriptional regulator
D0Z67_RS12150	COG2091	lysine biosynthetic process via aminoadipic acid
D0Z67_RS12165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0Z67_RS12180	COG0477	Major facilitator Superfamily
D0Z67_RS12190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Z67_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS12205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Z67_RS12210	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS12220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Z67_RS12225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Z67_RS12245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Z67_RS12255	COG3547	Transposase (IS116 IS110 IS902 family)
D0Z67_RS12260	COG2801	Transposase and inactivated derivatives
D0Z67_RS12335	COG0385	Bile acid
D0Z67_RS12350	COG0386	Belongs to the glutathione peroxidase family
D0Z67_RS12415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D0Z67_RS12440	COG3629	intracellular signal transduction
D0Z67_RS12440	COG3903	Transcriptional regulator
D0Z67_RS12450	COG0515	serine threonine protein kinase
D0Z67_RS12450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Z67_RS12460	COG1309	transcriptional regulator
D0Z67_RS12475	COG2072	flavoprotein involved in K transport
D0Z67_RS12500	COG1366	Belongs to the anti-sigma-factor antagonist family
D0Z67_RS12570	COG4821	SIS domain
D0Z67_RS12585	COG0259	pyridoxamine-phosphate oxidase activity
D0Z67_RS12610	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS12625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Z67_RS12645	COG5006	permease, DMT superfamily
D0Z67_RS12660	COG0277	FAD linked oxidase domain protein
D0Z67_RS12660	COG0247	lactate metabolic process
D0Z67_RS12665	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0Z67_RS12685	COG0667	Aldo Keto reductase
D0Z67_RS12715	COG2252	PERMEase
D0Z67_RS12725	COG3537	Alpha-1,2-mannosidase
D0Z67_RS12730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0Z67_RS12755	COG2814	Major facilitator Superfamily
D0Z67_RS12765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0Z67_RS12770	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D0Z67_RS12775	COG1278	Cold shock
D0Z67_RS12800	COG1061	Type III restriction enzyme res subunit
D0Z67_RS12815	COG3973	AAA domain
D0Z67_RS12840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Z67_RS12860	COG1737	Transcriptional regulator
D0Z67_RS12865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0Z67_RS12870	COG1263	PTS System
D0Z67_RS12870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Z67_RS12880	COG0346	lactoylglutathione lyase activity
D0Z67_RS12920	COG0459	protein refolding
D0Z67_RS12940	COG0463	Glycosyl transferase, family 2
D0Z67_RS12970	COG1846	Transcriptional regulator
D0Z67_RS12970	COG1940	carbohydrate kinase activity
D0Z67_RS12975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0Z67_RS12990	COG3300	MHYT domain
D0Z67_RS12990	COG5001	Diguanylate cyclase
D0Z67_RS13060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Z67_RS13065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Z67_RS13080	COG2329	Antibiotic biosynthesis monooxygenase
D0Z67_RS13095	COG1335	isochorismatase
D0Z67_RS13105	COG3842	ATPase activity
D0Z67_RS13130	COG0215	cysteine-tRNA ligase activity
D0Z67_RS13140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0Z67_RS13145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0Z67_RS13150	COG1329	Transcriptional regulator
D0Z67_RS13170	COG5002	protein histidine kinase activity
D0Z67_RS13235	COG0588	phosphoglycerate mutase activity
D0Z67_RS13240	COG2814	Major facilitator Superfamily
D0Z67_RS13260	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS13305	COG0667	Aldo Keto reductase
D0Z67_RS13325	COG2188	Transcriptional regulator
D0Z67_RS13335	COG4552	Acetyltransferase involved in intracellular survival and related
D0Z67_RS13345	COG1490	D-aminoacyl-tRNA deacylase activity
D0Z67_RS13365	COG0735	belongs to the Fur family
D0Z67_RS13370	COG3485	protocatechuate 3,4-dioxygenase
D0Z67_RS13395	COG2897	thiosulfate sulfurtransferase activity
D0Z67_RS13420	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS13425	COG1609	Transcriptional regulator
D0Z67_RS13430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Z67_RS13440	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS13445	COG2205	protein histidine kinase activity
D0Z67_RS13450	COG0488	(ABC) transporter
D0Z67_RS13455	COG0456	acetyltransferase
D0Z67_RS13460	COG1725	Transcriptional regulator
D0Z67_RS13465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0Z67_RS13475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0Z67_RS13495	COG1937	Protein conserved in bacteria
D0Z67_RS13505	COG0306	phosphate transporter
D0Z67_RS13510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0Z67_RS13530	COG0277	FAD linked oxidase domain protein
D0Z67_RS13535	COG0671	phosphoesterase, PA-phosphatase related
D0Z67_RS13540	COG0741	lytic transglycosylase activity
D0Z67_RS13540	COG0739	heme binding
D0Z67_RS13540	COG1196	nuclear chromosome segregation
D0Z67_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS13635	COG1252	NADH dehydrogenase
D0Z67_RS13645	COG1470	cell adhesion involved in biofilm formation
D0Z67_RS13645	COG0366	Alpha amylase catalytic
D0Z67_RS13660	COG0579	oxidoreductase
D0Z67_RS13665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0Z67_RS13675	COG0667	Aldo Keto reductase
D0Z67_RS13690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Z67_RS13690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Z67_RS13720	COG0513	Belongs to the DEAD box helicase family
D0Z67_RS13725	COG1278	Cold shock
D0Z67_RS13740	COG0513	Belongs to the DEAD box helicase family
D0Z67_RS13780	COG1643	Atp-dependent helicase
D0Z67_RS13810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0Z67_RS13830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Z67_RS13835	COG0047	phosphoribosylformylglycinamidine synthase activity
D0Z67_RS13840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Z67_RS13875	COG2197	response regulator
D0Z67_RS13885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0Z67_RS13900	COG0151	Belongs to the GarS family
D0Z67_RS13945	COG1276	copper resistance
D0Z67_RS13945	COG2372	response to copper ion
D0Z67_RS13960	COG2375	cellular response to nickel ion
D0Z67_RS13960	COG1132	(ABC) transporter
D0Z67_RS13980	COG0433	COG0433 Predicted ATPase
D0Z67_RS13995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0Z67_RS14030	COG1191	sigma factor activity
D0Z67_RS14035	COG1191	sigma factor activity
D0Z67_RS14050	COG0477	Major facilitator Superfamily
D0Z67_RS14055	COG2353	YceI-like domain
D0Z67_RS14060	COG3467	pyridoxamine 5'-phosphate
D0Z67_RS14070	COG0477	Major facilitator Superfamily
D0Z67_RS14075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0Z67_RS14085	COG2205	protein histidine kinase activity
D0Z67_RS14090	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS14110	COG1846	Transcriptional regulator
D0Z67_RS14135	COG0784	Response regulator, receiver
D0Z67_RS14140	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS14145	COG1595	DNA-templated transcription, initiation
D0Z67_RS14155	COG0583	DNA-binding transcription factor activity
D0Z67_RS14170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Z67_RS14210	COG0006	proline dipeptidase activity
D0Z67_RS14245	COG2837	iron assimilation
D0Z67_RS14250	COG0077	Prephenate dehydratase
D0Z67_RS14255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0Z67_RS14260	COG0561	phosphatase activity
D0Z67_RS14285	COG1131	(ABC) transporter
D0Z67_RS14295	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D0Z67_RS14305	COG0561	phosphatase activity
D0Z67_RS14310	COG4988	ABC transporter
D0Z67_RS14315	COG1294	oxidase, subunit
D0Z67_RS14320	COG1271	oxidase subunit
D0Z67_RS14325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Z67_RS14330	COG1609	Transcriptional regulator
D0Z67_RS14345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D0Z67_RS14370	COG0662	Cupin 2, conserved barrel domain protein
D0Z67_RS14375	COG1950	PFAM Membrane protein of
D0Z67_RS14380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Z67_RS14385	COG0626	cystathionine gamma-synthase activity
D0Z67_RS14415	COG2814	Major facilitator Superfamily
D0Z67_RS14435	COG0305	Participates in initiation and elongation during chromosome replication
D0Z67_RS14445	COG0359	binds to the 23S rRNA
D0Z67_RS14450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0Z67_RS14455	COG0629	single-stranded DNA binding
D0Z67_RS14460	COG0360	Binds together with S18 to 16S ribosomal RNA
D0Z67_RS14485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Z67_RS14495	COG1260	myo-inositol-1-phosphate synthase
D0Z67_RS14505	COG0617	tRNA 3'-terminal CCA addition
D0Z67_RS14520	COG2815	serine threonine protein kinase
D0Z67_RS14520	COG0515	serine threonine protein kinase
D0Z67_RS14525	COG1595	DNA-templated transcription, initiation
D0Z67_RS14535	COG0492	ferredoxin-NADP+ reductase activity
D0Z67_RS14540	COG3118	belongs to the thioredoxin family
D0Z67_RS14555	COG1192	Involved in chromosome partitioning
D0Z67_RS14560	COG0357	Ribosomal RNA small subunit methyltransferase G
D0Z67_RS14570	COG0706	membrane insertase activity
D0Z67_RS14575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0Z67_RS14580	COG0594	ribonuclease P activity
D0Z67_RS14585	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D0Z67_RS14605	COG0592	DNA-directed DNA polymerase activity
D0Z67_RS14610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D0Z67_RS14615	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0Z67_RS14620	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D0Z67_RS14625	COG0187	DNA topoisomerase II activity
D0Z67_RS14630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0Z67_RS14645	COG4249	Peptidase C14 caspase catalytic subunit p20
D0Z67_RS14645	COG2319	Wd-40 repeat
D0Z67_RS14670	COG0515	serine threonine protein kinase
D0Z67_RS14695	COG0705	Rhomboid family
D0Z67_RS14720	COG3764	Sortase (surface protein transpeptidase)
D0Z67_RS14725	COG3764	Sortase (surface protein transpeptidase)
D0Z67_RS14735	COG0515	serine threonine protein kinase
D0Z67_RS14740	COG0768	penicillin binding
D0Z67_RS14755	COG1716	ATPase activity
D0Z67_RS14760	COG1716	ATPase activity
D0Z67_RS14805	COG3629	intracellular signal transduction
D0Z67_RS14805	COG3903	Transcriptional regulator
D0Z67_RS14890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0Z67_RS14895	COG2151	metal-sulfur cluster biosynthetic enzyme
D0Z67_RS14900	COG3396	Phenylacetate-CoA oxygenase
D0Z67_RS14905	COG3460	Phenylacetate-CoA oxygenase
D0Z67_RS14910	COG3396	Phenylacetate-CoA oxygenase
D0Z67_RS14935	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z67_RS14940	COG1309	transcriptional regulator
D0Z67_RS14945	COG1522	sequence-specific DNA binding
D0Z67_RS14980	COG0604	alcohol dehydrogenase
D0Z67_RS14980	COG3321	synthase
D0Z67_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS14995	COG0515	serine threonine protein kinase
D0Z67_RS15000	COG0515	serine threonine protein kinase
D0Z67_RS15015	COG0022	dehydrogenase e1 component
D0Z67_RS15020	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Z67_RS15080	COG1362	aminopeptidase activity
D0Z67_RS15085	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS15095	COG1741	Belongs to the pirin family
D0Z67_RS15115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0Z67_RS15125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Z67_RS15135	COG1289	transmembrane transporter activity
D0Z67_RS15185	COG1957	nucleoside hydrolase
D0Z67_RS15190	COG0366	Alpha amylase catalytic
D0Z67_RS15235	COG0583	DNA-binding transcription factor activity
D0Z67_RS15295	COG0717	Belongs to the dCTP deaminase family
D0Z67_RS15300	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D0Z67_RS15305	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D0Z67_RS15305	COG1672	PFAM Archaeal ATPase
D0Z67_RS15335	COG0247	lactate metabolic process
D0Z67_RS15335	COG2181	nitrate reductase activity
D0Z67_RS15340	COG0443	Heat shock 70 kDa protein
D0Z67_RS15345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D0Z67_RS15350	COG0484	heat shock protein binding
D0Z67_RS15355	COG0789	Transcriptional regulator
D0Z67_RS15360	COG4213	ABC transporter substrate-binding protein
D0Z67_RS15390	COG0542	response to heat
D0Z67_RS15415	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D0Z67_RS15430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0Z67_RS15440	COG0477	Major facilitator Superfamily
D0Z67_RS15460	COG3483	tryptophan 2,3-dioxygenase activity
D0Z67_RS15465	COG3844	kynureninase activity
D0Z67_RS15480	COG2124	cytochrome p450
D0Z67_RS15520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0Z67_RS15550	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS15555	COG0583	DNA-binding transcription factor activity
D0Z67_RS15585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0Z67_RS15600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0Z67_RS15605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0Z67_RS15670	COG0701	Predicted permease
D0Z67_RS15690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z67_RS15695	COG0701	Predicted permease
D0Z67_RS15705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Z67_RS15710	COG1993	acr, cog1993
D0Z67_RS15715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Z67_RS15740	COG3209	COG3209 Rhs family protein
D0Z67_RS15780	COG1408	metallophosphoesterase
D0Z67_RS15785	COG1610	YqeY-like protein
D0Z67_RS15805	COG0003	Pfam Anion-transporting ATPase
D0Z67_RS15830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Z67_RS15865	COG0596	Alpha beta hydrolase
D0Z67_RS15880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0Z67_RS15945	COG1111	helicase
D0Z67_RS15945	COG1205	dead DEAH box helicase
D0Z67_RS15950	COG1366	Belongs to the anti-sigma-factor antagonist family
D0Z67_RS15960	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D0Z67_RS15980	COG1754	DNA topoisomerase type I activity
D0Z67_RS15980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0Z67_RS15985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0Z67_RS16010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0Z67_RS16010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0Z67_RS16050	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS16055	COG2318	DinB family
D0Z67_RS16060	COG0076	glutamate decarboxylase activity
D0Z67_RS16070	COG0789	Transcriptional regulator
D0Z67_RS16075	COG0393	Putative heavy-metal-binding
D0Z67_RS16090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0Z67_RS16095	COG2027	D-alanyl-D-alanine carboxypeptidase
D0Z67_RS16105	COG0037	tRNA processing
D0Z67_RS16120	COG0302	gtp cyclohydrolase
D0Z67_RS16135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0Z67_RS16150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D0Z67_RS16150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0Z67_RS16165	COG0649	NAD binding
D0Z67_RS16180	COG2197	response regulator
D0Z67_RS16190	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0Z67_RS16200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0Z67_RS16205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0Z67_RS16215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D0Z67_RS16230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0Z67_RS16285	COG2205	protein histidine kinase activity
D0Z67_RS16290	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS16300	COG1595	DNA-templated transcription, initiation
D0Z67_RS16305	COG1194	a g-specific adenine glycosylase
D0Z67_RS16315	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D0Z67_RS16335	COG0248	Ppx GppA phosphatase
D0Z67_RS16340	COG1082	Xylose isomerase domain protein TIM barrel
D0Z67_RS16345	COG1309	transcriptional regulator
D0Z67_RS16350	COG0129	dihydroxy-acid dehydratase activity
D0Z67_RS16355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Z67_RS16355	COG0515	serine threonine protein kinase
D0Z67_RS16360	COG4991	sh3 domain protein
D0Z67_RS16375	COG0842	Transport permease protein
D0Z67_RS16375	COG1129	ABC transporter
D0Z67_RS16385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0Z67_RS16410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Z67_RS16425	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0Z67_RS16475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D0Z67_RS16480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0Z67_RS16485	COG0181	hydroxymethylbilane synthase activity
D0Z67_RS16490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0Z67_RS16490	COG1648	precorrin-2 dehydrogenase activity
D0Z67_RS16500	COG0758	DNA mediated transformation
D0Z67_RS16510	COG0113	porphobilinogen synthase activity
D0Z67_RS16515	COG2268	Band 7 protein
D0Z67_RS16525	COG0018	arginyl-trna synthetase
D0Z67_RS16530	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D0Z67_RS16550	COG1690	Belongs to the RtcB family
D0Z67_RS16560	COG1742	UPF0060 membrane protein
D0Z67_RS16570	COG1846	Transcriptional regulator
D0Z67_RS16575	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS16625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0Z67_RS16630	COG0406	alpha-ribazole phosphatase activity
D0Z67_RS16645	COG0785	Cytochrome C biogenesis protein
D0Z67_RS16650	COG1333	cytochrome c biogenesis protein
D0Z67_RS16655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0Z67_RS16680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0Z67_RS16690	COG0163	prenyltransferase activity
D0Z67_RS16700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D0Z67_RS16720	COG2226	methyltransferase
D0Z67_RS16725	COG1278	Cold shock
D0Z67_RS16730	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D0Z67_RS16745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D0Z67_RS16755	COG2226	methyltransferase
D0Z67_RS16785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z67_RS16790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z67_RS16795	COG0649	NAD binding
D0Z67_RS16805	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D0Z67_RS16810	COG1034	ATP synthesis coupled electron transport
D0Z67_RS16815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D0Z67_RS16820	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z67_RS16825	COG0839	Belongs to the complex I subunit 6 family
D0Z67_RS16830	COG0713	ATP synthesis coupled electron transport
D0Z67_RS16835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0Z67_RS16845	COG1007	ATP synthesis coupled electron transport
D0Z67_RS16855	COG0514	ATP-dependent DNA helicase (RecQ)
D0Z67_RS16875	COG0492	ferredoxin-NADP+ reductase activity
D0Z67_RS16880	COG0561	phosphatase activity
D0Z67_RS16890	COG0142	geranyltranstransferase activity
D0Z67_RS16900	COG1131	(ABC) transporter
D0Z67_RS16935	COG0702	epimerase
D0Z67_RS16940	COG1733	regulation of RNA biosynthetic process
D0Z67_RS16945	COG1013	pyruvate-flavodoxin oxidoreductase activity
D0Z67_RS16950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D0Z67_RS16950	COG0674	pyruvate-flavodoxin oxidoreductase activity
D0Z67_RS16970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z67_RS16975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z67_RS16980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z67_RS16985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D0Z67_RS16990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z67_RS16995	COG0839	Belongs to the complex I subunit 6 family
D0Z67_RS17000	COG0713	ATP synthesis coupled electron transport
D0Z67_RS17015	COG1007	ATP synthesis coupled electron transport
D0Z67_RS17020	COG0501	Belongs to the peptidase M48B family
D0Z67_RS17025	COG3304	Inner membrane component domain
D0Z67_RS17030	COG2261	transglycosylase associated protein
D0Z67_RS17040	COG1666	GTP binding
D0Z67_RS17065	COG0702	epimerase
D0Z67_RS17070	COG0402	S-adenosylhomocysteine deaminase activity
D0Z67_RS17085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0Z67_RS17090	COG2030	dehydratase
D0Z67_RS17100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0Z67_RS17110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Z67_RS17115	COG0436	Aminotransferase
D0Z67_RS17130	COG0250	Participates in transcription elongation, termination and antitermination
D0Z67_RS17140	COG0081	regulation of translation
D0Z67_RS17150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0Z67_RS17155	COG0222	ribosome binding
D0Z67_RS17165	COG0085	RNA polymerase activity
D0Z67_RS17170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0Z67_RS17180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D0Z67_RS17185	COG0049	tRNA binding
D0Z67_RS17190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Z67_RS17195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0Z67_RS17200	COG0051	transcription antitermination factor activity, RNA binding
D0Z67_RS17205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0Z67_RS17210	COG0088	Forms part of the polypeptide exit tunnel
D0Z67_RS17215	COG0089	rRNA binding
D0Z67_RS17220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0Z67_RS17225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0Z67_RS17230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0Z67_RS17235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0Z67_RS17240	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D0Z67_RS17245	COG0255	Belongs to the universal ribosomal protein uL29 family
D0Z67_RS17250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0Z67_RS17255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0Z67_RS17260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D0Z67_RS17265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0Z67_RS17270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0Z67_RS17280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0Z67_RS17285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0Z67_RS17290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D0Z67_RS17295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D0Z67_RS17300	COG1841	ribosomal large subunit assembly
D0Z67_RS17305	COG0200	Binds to the 23S rRNA
D0Z67_RS17315	COG0563	adenylate kinase activity
D0Z67_RS17325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0Z67_RS17330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0Z67_RS17335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0Z67_RS17340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0Z67_RS17345	COG0202	RNA polymerase activity
D0Z67_RS17350	COG0203	ribosomal protein L17
D0Z67_RS17355	COG0101	tRNA pseudouridine synthase activity
D0Z67_RS17365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0Z67_RS17370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0Z67_RS17375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0Z67_RS17385	COG1072	(Pantothenic acid kinase))
D0Z67_RS17395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Z67_RS17400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Z67_RS17405	COG0736	holo-[acyl-carrier-protein] synthase activity
D0Z67_RS17415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0Z67_RS17425	COG0802	atpase or kinase
D0Z67_RS17445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0Z67_RS17455	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Z67_RS17465	COG1175	transmembrane transport
D0Z67_RS17475	COG1609	Transcriptional regulator
D0Z67_RS17485	COG0726	polysaccharide deacetylase
D0Z67_RS17500	COG0459	protein refolding
D0Z67_RS17505	COG4221	oxidoreductase activity
D0Z67_RS17515	COG0583	DNA-binding transcription factor activity
D0Z67_RS17530	COG1595	DNA-templated transcription, initiation
D0Z67_RS17540	COG0516	GMP reductase activity
D0Z67_RS17550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0Z67_RS17565	COG0515	serine threonine protein kinase
D0Z67_RS17570	COG0515	serine threonine protein kinase
D0Z67_RS17575	COG0515	serine threonine protein kinase
D0Z67_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS17600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0Z67_RS17600	COG0519	Catalyzes the synthesis of GMP from XMP
D0Z67_RS17635	COG2197	response regulator
D0Z67_RS17680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0Z67_RS17680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0Z67_RS17695	COG0714	Associated with various cellular activities
D0Z67_RS17700	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D0Z67_RS17705	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D0Z67_RS17710	COG0045	succinate-CoA ligase (ADP-forming) activity
D0Z67_RS17740	COG0138	bifunctional purine biosynthesis protein purh
D0Z67_RS17745	COG1714	RDD family
D0Z67_RS17750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0Z67_RS17765	COG0039	L-malate dehydrogenase activity
D0Z67_RS17775	COG0477	Major facilitator Superfamily
D0Z67_RS17805	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS17815	COG4175	Glycine betaine
D0Z67_RS17815	COG0517	IMP dehydrogenase activity
D0Z67_RS17820	COG4176	ABC-type proline glycine betaine transport system permease component
D0Z67_RS17830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z67_RS17835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z67_RS17850	COG0754	glutathionylspermidine amidase activity
D0Z67_RS17855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0Z67_RS17860	COG0180	Tryptophanyl-tRNA synthetase
D0Z67_RS17875	COG1295	ribonuclease BN
D0Z67_RS17890	COG1408	metallophosphoesterase
D0Z67_RS17895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0Z67_RS17945	COG1309	transcriptional regulator
D0Z67_RS17975	COG1053	succinate dehydrogenase
D0Z67_RS17985	COG2009	succinate dehydrogenase
D0Z67_RS17995	COG3583	domain protein
D0Z67_RS17995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D0Z67_RS17995	COG3064	Membrane
D0Z67_RS18015	COG1959	2 iron, 2 sulfur cluster binding
D0Z67_RS18020	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS18030	COG1595	DNA-templated transcription, initiation
D0Z67_RS18070	COG1216	Glycosyl transferase, family 2
D0Z67_RS18080	COG1083	cytidylyl-transferase
D0Z67_RS18085	COG2089	acid synthase
D0Z67_RS18100	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D0Z67_RS18100	COG1473	amidohydrolase
D0Z67_RS18105	COG1744	ABC transporter substrate-binding protein PnrA-like
D0Z67_RS18110	COG3845	ABC transporter
D0Z67_RS18115	COG4603	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS18120	COG1079	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS18140	COG1309	transcriptional regulator
D0Z67_RS18145	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z67_RS18165	COG2814	Major facilitator Superfamily
D0Z67_RS18170	COG0583	DNA-binding transcription factor activity
D0Z67_RS18200	COG2205	protein histidine kinase activity
D0Z67_RS18205	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS18210	COG1595	DNA-templated transcription, initiation
D0Z67_RS18225	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS18230	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS18235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D0Z67_RS18265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0Z67_RS18285	COG4770	biotin carboxylase activity
D0Z67_RS18295	COG0424	maF-like protein
D0Z67_RS18300	COG2801	Transposase and inactivated derivatives
D0Z67_RS18300	COG3415	Transposase
D0Z67_RS18310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Z67_RS18320	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D0Z67_RS18330	COG1024	Enoyl-CoA hydratase
D0Z67_RS18340	COG2986	histidine ammonia-lyase
D0Z67_RS18365	COG1064	alcohol dehydrogenase
D0Z67_RS18370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Z67_RS18395	COG2255	four-way junction helicase activity
D0Z67_RS18400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0Z67_RS18415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Z67_RS18425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0Z67_RS18450	COG1309	transcriptional regulator
D0Z67_RS18460	COG0475	glutathione-regulated potassium exporter activity
D0Z67_RS18480	COG1331	Highly conserved protein containing a thioredoxin domain
D0Z67_RS18500	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D0Z67_RS18510	COG0436	Aminotransferase
D0Z67_RS18520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D0Z67_RS18535	COG1414	Transcriptional regulator
D0Z67_RS18540	COG0251	oxidation-reduction process
D0Z67_RS18545	COG2610	gluconate transmembrane transporter activity
D0Z67_RS18570	COG2894	cell division
D0Z67_RS18600	COG3850	Histidine kinase
D0Z67_RS18605	COG2197	response regulator
D0Z67_RS18640	COG2226	methyltransferase
D0Z67_RS18645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0Z67_RS18655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0Z67_RS18660	COG0741	lytic transglycosylase activity
D0Z67_RS18670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z67_RS18675	COG0450	alkyl hydroperoxide reductase
D0Z67_RS18690	COG1136	(ABC) transporter
D0Z67_RS18700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Z67_RS18715	COG0114	fumarate hydratase activity
D0Z67_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS18725	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0Z67_RS18725	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0Z67_RS18750	COG0778	Nitroreductase
D0Z67_RS18755	COG1722	exodeoxyribonuclease VII activity
D0Z67_RS18760	COG1570	exodeoxyribonuclease VII activity
D0Z67_RS18765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0Z67_RS18785	COG0012	GTP binding
D0Z67_RS18790	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D0Z67_RS18800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D0Z67_RS18820	COG4974	Belongs to the 'phage' integrase family
D0Z67_RS18900	COG1217	gtp-binding protein TYPA
D0Z67_RS18915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z67_RS18920	COG0444	Belongs to the ABC transporter superfamily
D0Z67_RS18925	COG4608	Belongs to the ABC transporter superfamily
D0Z67_RS18935	COG0444	Belongs to the ABC transporter superfamily
D0Z67_RS18945	COG0601	transmembrane transport
D0Z67_RS18950	COG0747	negative chemotaxis
D0Z67_RS18965	COG0601	transmembrane transport
D0Z67_RS18970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z67_RS18975	COG0444	Belongs to the ABC transporter superfamily
D0Z67_RS18980	COG4608	Belongs to the ABC transporter superfamily
D0Z67_RS18995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0Z67_RS19000	COG2318	DinB family
D0Z67_RS19010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0Z67_RS19030	COG1131	(ABC) transporter
D0Z67_RS19040	COG4585	Histidine kinase
D0Z67_RS19045	COG2197	response regulator
D0Z67_RS19080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Z67_RS19085	COG1611	Belongs to the LOG family
D0Z67_RS19090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0Z67_RS19100	COG0519	Catalyzes the synthesis of GMP from XMP
D0Z67_RS19105	COG1024	Enoyl-CoA hydratase
D0Z67_RS19120	COG1595	DNA-templated transcription, initiation
D0Z67_RS19130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Z67_RS19135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Z67_RS19170	COG0598	Magnesium transport protein CorA
D0Z67_RS19190	COG2095	MarC family integral membrane protein
D0Z67_RS19195	COG1432	Conserved Protein
D0Z67_RS19200	COG0513	Belongs to the DEAD box helicase family
D0Z67_RS19240	COG0747	negative chemotaxis
D0Z67_RS19245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z67_RS19250	COG0601	transmembrane transport
D0Z67_RS19315	COG0210	DNA helicase
D0Z67_RS19320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Z67_RS19355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0Z67_RS19405	COG3480	Lon protease (S16) C-terminal proteolytic domain
D0Z67_RS19415	COG1615	UPF0182 protein
D0Z67_RS19445	COG0483	inositol monophosphate 1-phosphatase activity
D0Z67_RS19455	COG2076	Multidrug Resistance protein
D0Z67_RS19460	COG1162	GTPase activity
D0Z67_RS19465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0Z67_RS19475	COG2135	peptidase activity
D0Z67_RS19485	COG1595	DNA-templated transcription, initiation
D0Z67_RS19490	COG5662	AntiSigma factor
D0Z67_RS19495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0Z67_RS19495	COG2199	diguanylate cyclase activity
D0Z67_RS19510	COG0242	peptide deformylase activity
D0Z67_RS19520	COG2124	cytochrome p450
D0Z67_RS19535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Z67_RS19560	COG2188	Transcriptional regulator
D0Z67_RS19565	COG2182	Extracellular solute-binding protein
D0Z67_RS19570	COG1175	transmembrane transport
D0Z67_RS19575	COG0395	ABC-type sugar transport system, permease component
D0Z67_RS19580	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Z67_RS19585	COG0363	glucosamine-6-phosphate deaminase activity
D0Z67_RS19600	COG1597	lipid kinase activity
D0Z67_RS19615	COG2172	sigma factor antagonist activity
D0Z67_RS19645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Z67_RS19650	COG0142	geranyltranstransferase activity
D0Z67_RS19660	COG1295	ribonuclease BN
D0Z67_RS19680	COG4106	trans-aconitate 2-methyltransferase activity
D0Z67_RS19685	COG1126	abc transporter atp-binding protein
D0Z67_RS19700	COG0281	malic enzyme
D0Z67_RS19705	COG0604	alcohol dehydrogenase
D0Z67_RS19775	COG0567	Dehydrogenase, E1 component
D0Z67_RS19775	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Z67_RS19785	COG2205	protein histidine kinase activity
D0Z67_RS19790	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS19795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D0Z67_RS19800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0Z67_RS19845	COG3883	PFAM NLP P60 protein
D0Z67_RS19845	COG0791	NLP P60 protein
D0Z67_RS19870	COG0772	Belongs to the SEDS family
D0Z67_RS19880	COG3285	dna ligase
D0Z67_RS19880	COG1793	dna ligase
D0Z67_RS19885	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D0Z67_RS19905	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS19915	COG0019	diaminopimelate decarboxylase activity
D0Z67_RS19920	COG0460	homoserine dehydrogenase
D0Z67_RS19925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0Z67_RS19930	COG0083	homoserine kinase activity
D0Z67_RS19945	COG0254	rRNA binding
D0Z67_RS19950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0Z67_RS19955	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Z67_RS19965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Z67_RS19970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0Z67_RS19990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0Z67_RS19995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D0Z67_RS20000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0Z67_RS20005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0Z67_RS20010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0Z67_RS20015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0Z67_RS20020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0Z67_RS20060	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z67_RS20075	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D0Z67_RS20120	COG0183	Belongs to the thiolase family
D0Z67_RS20185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0Z67_RS20185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0Z67_RS20225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0Z67_RS20230	COG0857	belongs to the CobB CobQ family
D0Z67_RS20230	COG0280	phosphate acetyltransferase
D0Z67_RS20235	COG0205	6-phosphofructokinase activity
D0Z67_RS20240	COG4565	transcriptional regulatory protein
D0Z67_RS20245	COG3290	protein histidine kinase activity
D0Z67_RS20250	COG1301	dicarboxylic acid transport
D0Z67_RS20260	COG0477	Major facilitator Superfamily
D0Z67_RS20315	COG1674	ftsk spoiiie
D0Z67_RS20330	COG3118	belongs to the thioredoxin family
D0Z67_RS20340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0Z67_RS20345	COG3281	Trehalose synthase
D0Z67_RS20355	COG0366	Alpha amylase catalytic
D0Z67_RS20360	COG0058	SHG alpha-glucan phosphorylase activity
D0Z67_RS20385	COG1132	(ABC) transporter
D0Z67_RS20395	COG1132	(ABC) transporter
D0Z67_RS20400	COG1132	(ABC) transporter
D0Z67_RS20410	COG1376	ErfK ybiS ycfS ynhG family protein
D0Z67_RS20415	COG1376	ErfK ybiS ycfS ynhG family protein
D0Z67_RS20460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS20465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0Z67_RS20470	COG1760	l-serine dehydratase
D0Z67_RS20475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0Z67_RS20480	COG0509	glycine decarboxylation via glycine cleavage system
D0Z67_RS20485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0Z67_RS20505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z67_RS20510	COG0747	negative chemotaxis
D0Z67_RS20520	COG0444	Belongs to the ABC transporter superfamily
D0Z67_RS20530	COG2860	membrane
D0Z67_RS20560	COG0482	sulfurtransferase activity
D0Z67_RS20580	COG4221	oxidoreductase activity
D0Z67_RS20590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0Z67_RS20600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0Z67_RS20605	COG0154	amidase activity
D0Z67_RS20615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0Z67_RS20630	COG2133	pyrroloquinoline quinone binding
D0Z67_RS20635	COG0667	Aldo Keto reductase
D0Z67_RS20660	COG0440	acetolactate synthase activity
D0Z67_RS20665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0Z67_RS20670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Z67_RS20675	COG0477	Major facilitator Superfamily
D0Z67_RS20685	COG2508	Transcriptional regulator
D0Z67_RS20690	COG0506	proline dehydrogenase activity
D0Z67_RS20695	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS20710	COG0473	3-isopropylmalate dehydrogenase activity
D0Z67_RS20715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0Z67_RS20720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0Z67_RS20735	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Z67_RS20755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Z67_RS20780	COG2018	Roadblock/LC7 domain
D0Z67_RS20800	COG2018	Roadblock/LC7 domain
D0Z67_RS20805	COG5002	protein histidine kinase activity
D0Z67_RS20815	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0Z67_RS20820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Z67_RS20855	COG1414	Transcriptional regulator
D0Z67_RS20860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D0Z67_RS20865	COG0066	3-isopropylmalate dehydratase activity
D0Z67_RS20875	COG0776	regulation of translation
D0Z67_RS20885	COG1920	GTP binding
D0Z67_RS20895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0Z67_RS20900	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Z67_RS20920	COG0351	phosphomethylpyrimidine kinase
D0Z67_RS20925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0Z67_RS20940	COG0326	Molecular chaperone. Has ATPase activity
D0Z67_RS20950	COG0742	ribosomal rna small subunit methyltransferase
D0Z67_RS20955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0Z67_RS20970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D0Z67_RS20975	COG0571	ribonuclease III activity
D0Z67_RS20980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0Z67_RS20985	COG1733	regulation of RNA biosynthetic process
D0Z67_RS20995	COG2340	Cysteine-rich secretory protein family
D0Z67_RS21000	COG1254	Belongs to the acylphosphatase family
D0Z67_RS21020	COG0477	Major facilitator Superfamily
D0Z67_RS21060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0Z67_RS21070	COG2801	Transposase and inactivated derivatives
D0Z67_RS21070	COG3415	Transposase
D0Z67_RS21075	COG4106	trans-aconitate 2-methyltransferase activity
D0Z67_RS21085	COG0228	four-way junction DNA binding
D0Z67_RS21090	COG1837	Belongs to the UPF0109 family
D0Z67_RS21095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0Z67_RS21100	COG0336	Belongs to the RNA methyltransferase TrmD family
D0Z67_RS21105	COG0335	large ribosomal subunit rRNA binding
D0Z67_RS21120	COG0681	Belongs to the peptidase S26 family
D0Z67_RS21140	COG0792	nuclease activity
D0Z67_RS21155	COG1191	sigma factor activity
D0Z67_RS21170	COG0052	Belongs to the universal ribosomal protein uS2 family
D0Z67_RS21175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0Z67_RS21180	COG0528	UMP kinase activity
D0Z67_RS21185	COG0233	cytoplasmic translational termination
D0Z67_RS21190	COG0575	Belongs to the CDS family
D0Z67_RS21195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0Z67_RS21205	COG4208	sulfate ABC transporter
D0Z67_RS21210	COG3842	ATPase activity
D0Z67_RS21245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Z67_RS21255	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS21285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Z67_RS21295	COG0584	glycerophosphoryl diester phosphodiesterase
D0Z67_RS21300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Z67_RS21325	COG3842	ATPase activity
D0Z67_RS21330	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0Z67_RS21335	COG1177	transmembrane transport
D0Z67_RS21340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z67_RS21370	COG2508	Transcriptional regulator
D0Z67_RS21375	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS21380	COG2116	formate transmembrane transporter activity
D0Z67_RS21395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0Z67_RS21400	COG0750	zinc metalloprotease
D0Z67_RS21405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0Z67_RS21435	COG0442	prolyl-tRNA aminoacylation
D0Z67_RS21460	COG0779	Required for maturation of 30S ribosomal subunits
D0Z67_RS21475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0Z67_RS21485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0Z67_RS21490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0Z67_RS21505	COG0455	bacterial-type flagellum organization
D0Z67_RS21525	COG1404	Belongs to the peptidase S8 family
D0Z67_RS21565	COG1404	Belongs to the peptidase S8 family
D0Z67_RS21580	COG1674	ftsk spoiiie
D0Z67_RS21590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0Z67_RS21595	COG1185	polyribonucleotide nucleotidyltransferase activity
D0Z67_RS21600	COG0612	Peptidase, M16
D0Z67_RS21605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0Z67_RS21625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D0Z67_RS21630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Z67_RS21635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D0Z67_RS21670	COG2770	Histidine kinase
D0Z67_RS21670	COG2208	phosphoserine phosphatase activity
D0Z67_RS21680	COG2205	protein histidine kinase activity
D0Z67_RS21680	COG0784	Response regulator, receiver
D0Z67_RS21690	COG1674	ftsk spoiiie
D0Z67_RS21700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0Z67_RS21710	COG1058	Belongs to the CinA family
D0Z67_RS21710	COG1546	Belongs to the CinA family
D0Z67_RS21715	COG1396	sequence-specific DNA binding
D0Z67_RS21720	COG0783	Belongs to the Dps family
D0Z67_RS21730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0Z67_RS21735	COG1201	RNA secondary structure unwinding
D0Z67_RS21775	COG1104	cysteine desulfurase activity
D0Z67_RS21835	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D0Z67_RS21840	COG1024	Enoyl-CoA hydratase
D0Z67_RS21885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0Z67_RS21895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0Z67_RS21905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Z67_RS21910	COG0765	amino acid transport
D0Z67_RS21915	COG0765	amino acid transport
D0Z67_RS21920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z67_RS21925	COG1126	abc transporter atp-binding protein
D0Z67_RS21930	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS21935	COG2205	protein histidine kinase activity
D0Z67_RS21950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0Z67_RS21965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0Z67_RS21980	COG3415	Transposase
D0Z67_RS21980	COG2801	Transposase and inactivated derivatives
D0Z67_RS21985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0Z67_RS21990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Z67_RS22000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0Z67_RS22030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0Z67_RS22035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0Z67_RS22040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Z67_RS22055	COG0588	phosphoglycerate mutase activity
D0Z67_RS22065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0Z67_RS22090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0Z67_RS22095	COG2814	Major facilitator Superfamily
D0Z67_RS22100	COG0514	ATP-dependent DNA helicase (RecQ)
D0Z67_RS22115	COG3842	ATPase activity
D0Z67_RS22125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Z67_RS22140	COG0187	DNA topoisomerase II activity
D0Z67_RS22155	COG2197	response regulator
D0Z67_RS22165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Z67_RS22180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z67_RS22190	COG2801	Transposase and inactivated derivatives
D0Z67_RS22190	COG3415	Transposase
D0Z67_RS22195	COG3290	protein histidine kinase activity
D0Z67_RS22210	COG0372	Belongs to the citrate synthase family
D0Z67_RS22220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0Z67_RS22225	COG0612	Peptidase, M16
D0Z67_RS22240	COG1802	Transcriptional regulator
D0Z67_RS22245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Z67_RS22265	COG1435	thymidine kinase activity
D0Z67_RS22300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0Z67_RS22310	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS22315	COG2205	protein histidine kinase activity
D0Z67_RS22375	COG0569	domain protein
D0Z67_RS22380	COG0531	amino acid
D0Z67_RS22385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0Z67_RS22410	COG2175	clavaminate synthase activity
D0Z67_RS22420	COG3251	PFAM MbtH domain protein
D0Z67_RS22435	COG3850	Histidine kinase
D0Z67_RS22440	COG2197	response regulator
D0Z67_RS22460	COG2197	response regulator
D0Z67_RS22465	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS22480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0Z67_RS22525	COG0156	8-amino-7-oxononanoate synthase activity
D0Z67_RS22530	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS22540	COG3321	synthase
D0Z67_RS22540	COG0604	alcohol dehydrogenase
D0Z67_RS22545	COG0477	Major facilitator Superfamily
D0Z67_RS22555	COG2197	response regulator
D0Z67_RS22575	COG0456	acetyltransferase
D0Z67_RS22670	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS22710	COG1799	cell septum assembly
D0Z67_RS22740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0Z67_RS22755	COG2235	arginine
D0Z67_RS22760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0Z67_RS22765	COG0531	amino acid
D0Z67_RS22790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS22795	COG3511	phospholipase C
D0Z67_RS22810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0Z67_RS22825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0Z67_RS22825	COG3321	synthase
D0Z67_RS22825	COG4221	oxidoreductase activity
D0Z67_RS22825	COG0604	alcohol dehydrogenase
D0Z67_RS22830	COG1733	regulation of RNA biosynthetic process
D0Z67_RS22835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0Z67_RS22850	COG0671	phosphoesterase, PA-phosphatase related
D0Z67_RS22855	COG1295	ribonuclease BN
D0Z67_RS22870	COG1653	transport
D0Z67_RS22875	COG1175	transmembrane transport
D0Z67_RS22880	COG0395	ABC-type sugar transport system, permease component
D0Z67_RS22890	COG4213	ABC transporter substrate-binding protein
D0Z67_RS22900	COG4214	carbohydrate transport
D0Z67_RS22905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0Z67_RS22910	COG0531	amino acid
D0Z67_RS22930	COG1316	TRANSCRIPTIONal
D0Z67_RS22935	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0Z67_RS22955	COG1024	Enoyl-CoA hydratase
D0Z67_RS22955	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z67_RS22960	COG0183	Belongs to the thiolase family
D0Z67_RS22965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0Z67_RS22980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D0Z67_RS22995	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Z67_RS23005	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D0Z67_RS23010	COG3253	May function as heme-dependent peroxidase
D0Z67_RS23025	COG3220	belongs to the UPF0276 family
D0Z67_RS23040	COG0330	HflC and HflK could
D0Z67_RS23045	COG0659	secondary active sulfate transmembrane transporter activity
D0Z67_RS23075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Z67_RS23080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Z67_RS23090	COG1174	glycine betaine transport
D0Z67_RS23095	COG1174	glycine betaine transport
D0Z67_RS23105	COG0640	Transcriptional regulator
D0Z67_RS23110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0Z67_RS23115	COG1316	TRANSCRIPTIONal
D0Z67_RS23120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Z67_RS23145	COG1309	transcriptional regulator
D0Z67_RS23215	COG1175	transmembrane transport
D0Z67_RS23245	COG2801	Transposase and inactivated derivatives
D0Z67_RS23245	COG3415	Transposase
D0Z67_RS23265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0Z67_RS23265	COG1116	anion transmembrane transporter activity
D0Z67_RS23290	COG0529	Catalyzes the synthesis of activated sulfate
D0Z67_RS23295	COG0175	sulfate reduction
D0Z67_RS23330	COG2040	homocysteine
D0Z67_RS23345	COG0277	FAD linked oxidase domain protein
D0Z67_RS23370	COG1162	GTPase activity
D0Z67_RS23380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Z67_RS23400	COG0028	Belongs to the TPP enzyme family
D0Z67_RS23420	COG1802	Transcriptional regulator
D0Z67_RS23430	COG3835	regulator
D0Z67_RS23445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0Z67_RS23475	COG2197	response regulator
D0Z67_RS23480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0Z67_RS23485	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS23500	COG3537	Alpha-1,2-mannosidase
D0Z67_RS23520	COG2351	hydroxyisourate hydrolase activity
D0Z67_RS23545	COG1733	regulation of RNA biosynthetic process
D0Z67_RS23560	COG4264	IucA IucC family
D0Z67_RS23625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0Z67_RS23635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0Z67_RS23640	COG4266	Belongs to the allantoicase family
D0Z67_RS23645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0Z67_RS23655	COG0673	inositol 2-dehydrogenase activity
D0Z67_RS23660	COG2188	Transcriptional regulator
D0Z67_RS23670	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS23675	COG1129	ABC transporter
D0Z67_RS23680	COG1940	carbohydrate kinase activity
D0Z67_RS23690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0Z67_RS23700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z67_RS23705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D0Z67_RS23720	COG1126	abc transporter atp-binding protein
D0Z67_RS23730	COG0765	amino acid transport
D0Z67_RS23735	COG0765	amino acid transport
D0Z67_RS23765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0Z67_RS23770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z67_RS23775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0Z67_RS23780	COG0477	Major facilitator Superfamily
D0Z67_RS23795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0Z67_RS23805	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS23825	COG0529	Catalyzes the synthesis of activated sulfate
D0Z67_RS23845	COG0405	Gamma-glutamyltransferase
D0Z67_RS23850	COG0542	response to heat
D0Z67_RS23875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Z67_RS23890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0Z67_RS23900	COG1953	Uracil, thiamine, allantoin
D0Z67_RS23920	COG0483	inositol monophosphate 1-phosphatase activity
D0Z67_RS23950	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS23975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0Z67_RS23985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Z67_RS23990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0Z67_RS24000	COG3415	Transposase
D0Z67_RS24000	COG2801	Transposase and inactivated derivatives
D0Z67_RS24015	COG1929	Belongs to the glycerate kinase type-1 family
D0Z67_RS24025	COG0688	phosphatidylethanolamine metabolic process
D0Z67_RS24030	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS24040	COG2301	Belongs to the HpcH HpaI aldolase family
D0Z67_RS24045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0Z67_RS24045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0Z67_RS24050	COG0604	alcohol dehydrogenase
D0Z67_RS24060	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z67_RS24095	COG1366	Belongs to the anti-sigma-factor antagonist family
D0Z67_RS24095	COG2172	sigma factor antagonist activity
D0Z67_RS24095	COG2208	phosphoserine phosphatase activity
D0Z67_RS24100	COG4106	trans-aconitate 2-methyltransferase activity
D0Z67_RS24105	COG2362	D-Aminopeptidase
D0Z67_RS24110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Z67_RS24115	COG4946	Tricorn protease homolog
D0Z67_RS24115	COG1506	peptidase
D0Z67_RS24115	COG0823	Involved in the tonB-independent uptake of proteins
D0Z67_RS24120	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0Z67_RS24145	COG2801	Transposase and inactivated derivatives
D0Z67_RS24145	COG3415	Transposase
D0Z67_RS24150	COG2226	methyltransferase
D0Z67_RS24155	COG1597	lipid kinase activity
D0Z67_RS24210	COG2813	Specifically methylates the guanine in position
D0Z67_RS24215	COG4106	trans-aconitate 2-methyltransferase activity
D0Z67_RS24225	COG0656	L-ascorbic acid biosynthetic process
D0Z67_RS24235	COG0583	DNA-binding transcription factor activity
D0Z67_RS24245	COG1335	isochorismatase
D0Z67_RS24255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Z67_RS24285	COG1175	transmembrane transport
D0Z67_RS24290	COG0395	ABC-type sugar transport system, permease component
D0Z67_RS24295	COG2723	6-phospho-beta-galactosidase activity
D0Z67_RS24325	COG0297	glycogen (starch) synthase activity
D0Z67_RS24345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0Z67_RS24355	COG3467	pyridoxamine 5'-phosphate
D0Z67_RS24365	COG0406	alpha-ribazole phosphatase activity
D0Z67_RS24370	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D0Z67_RS24375	COG0166	Belongs to the GPI family
D0Z67_RS24390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0Z67_RS24395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0Z67_RS24420	COG0326	Molecular chaperone. Has ATPase activity
D0Z67_RS24425	COG1486	melibiose metabolic process
D0Z67_RS24430	COG3469	chitinase activity
D0Z67_RS24475	COG1175	transmembrane transport
D0Z67_RS24480	COG0395	ABC-type sugar transport system, permease component
D0Z67_RS24485	COG0366	Alpha amylase catalytic
D0Z67_RS24545	COG1672	PFAM Archaeal ATPase
D0Z67_RS24545	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D0Z67_RS24550	COG1793	dna ligase
D0Z67_RS24580	COG0488	(ABC) transporter
D0Z67_RS24600	COG1515	deoxyribonuclease V activity
D0Z67_RS24610	COG3268	Saccharopine dehydrogenase
D0Z67_RS24615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z67_RS24620	COG0183	Belongs to the thiolase family
D0Z67_RS24625	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z67_RS24625	COG1024	Enoyl-CoA hydratase
D0Z67_RS24655	COG2801	Transposase and inactivated derivatives
D0Z67_RS24655	COG3415	Transposase
D0Z67_RS24670	COG0789	Transcriptional regulator
D0Z67_RS24675	COG1113	amino acid transport
D0Z67_RS24685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z67_RS24695	COG2936	dipeptidyl-peptidase activity
D0Z67_RS24710	COG0488	(ABC) transporter
D0Z67_RS24715	COG2183	response to ionizing radiation
D0Z67_RS24730	COG1024	Enoyl-CoA hydratase
D0Z67_RS24745	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D0Z67_RS24790	COG1134	teichoic acid transport
D0Z67_RS24795	COG1562	ergosterol biosynthetic process
D0Z67_RS24805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D0Z67_RS24815	COG1657	PFAM Prenyltransferase squalene oxidase
D0Z67_RS24830	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0Z67_RS24835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0Z67_RS24855	COG2365	Tyrosine phosphatase family
D0Z67_RS24860	COG2755	lipolytic protein G-D-S-L family
D0Z67_RS24880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z67_RS24885	COG4521	taurine ABC transporter
D0Z67_RS24890	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D0Z67_RS24895	COG2175	clavaminate synthase activity
D0Z67_RS24910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS24925	COG0765	amino acid transport
D0Z67_RS24935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z67_RS24940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS24955	COG0431	NADPH-dependent FMN reductase
D0Z67_RS24960	COG0659	secondary active sulfate transmembrane transporter activity
D0Z67_RS25005	COG1063	alcohol dehydrogenase
D0Z67_RS25010	COG0156	8-amino-7-oxononanoate synthase activity
D0Z67_RS25015	COG0583	DNA-binding transcription factor activity
D0Z67_RS25025	COG3958	Transketolase
D0Z67_RS25030	COG3959	Transketolase, thiamine diphosphate binding domain
D0Z67_RS25080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Z67_RS25125	COG0583	DNA-binding transcription factor activity
D0Z67_RS25135	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS25140	COG1309	transcriptional regulator
D0Z67_RS25150	COG2076	Multidrug Resistance protein
D0Z67_RS25155	COG2076	Multidrug Resistance protein
D0Z67_RS25190	COG1414	Transcriptional regulator
D0Z67_RS25210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS25235	COG1063	alcohol dehydrogenase
D0Z67_RS25275	COG2267	carboxylic ester hydrolase activity
D0Z67_RS25280	COG0183	Belongs to the thiolase family
D0Z67_RS25285	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS25310	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS25370	COG4221	oxidoreductase activity
D0Z67_RS25405	COG1597	lipid kinase activity
D0Z67_RS25420	COG1725	Transcriptional regulator
D0Z67_RS25425	COG3842	ATPase activity
D0Z67_RS25455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Z67_RS25490	COG0531	amino acid
D0Z67_RS25510	COG0673	inositol 2-dehydrogenase activity
D0Z67_RS25565	COG0477	Major facilitator Superfamily
D0Z67_RS25605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Z67_RS25610	COG1012	belongs to the aldehyde dehydrogenase family
D0Z67_RS25620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Z67_RS25625	COG3622	Belongs to the hyi family
D0Z67_RS25630	COG2271	Major facilitator Superfamily
D0Z67_RS25635	COG0235	Class ii aldolase
D0Z67_RS25640	COG3395	kinase activity
D0Z67_RS25645	COG2084	Dehydrogenase
D0Z67_RS25650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Z67_RS25665	COG1335	isochorismatase
D0Z67_RS25670	COG0477	Major facilitator Superfamily
D0Z67_RS25680	COG0494	nUDIX hydrolase
D0Z67_RS25685	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z67_RS25705	COG2318	DinB family
D0Z67_RS25715	COG0596	Alpha beta hydrolase
D0Z67_RS25730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Z67_RS25740	COG2838	Isocitrate dehydrogenase
D0Z67_RS25755	COG0668	transmembrane transport
D0Z67_RS25765	COG1024	Enoyl-CoA hydratase
D0Z67_RS25770	COG1132	(ABC) transporter
D0Z67_RS25785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Z67_RS25790	COG3275	phosphorelay sensor kinase activity
D0Z67_RS25820	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS25885	COG0596	Alpha beta hydrolase
D0Z67_RS25900	COG0477	Major facilitator Superfamily
D0Z67_RS25960	COG0300	oxidoreductase activity
D0Z67_RS25965	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS25970	COG2378	regulation of single-species biofilm formation
D0Z67_RS25975	COG2814	Major facilitator Superfamily
D0Z67_RS25990	COG1414	Transcriptional regulator
D0Z67_RS25995	COG0800	Aldolase
D0Z67_RS26000	COG4948	Mandelate Racemase Muconate Lactonizing
D0Z67_RS26060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D0Z67_RS26095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0Z67_RS26115	COG0297	glycogen (starch) synthase activity
D0Z67_RS26120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0Z67_RS26125	COG3537	Alpha-1,2-mannosidase
D0Z67_RS26150	COG0154	amidase activity
D0Z67_RS26165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0Z67_RS26190	COG0531	amino acid
D0Z67_RS26210	COG0726	polysaccharide deacetylase
D0Z67_RS26265	COG1053	succinate dehydrogenase
D0Z67_RS26270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0Z67_RS26290	COG3360	Dodecin
D0Z67_RS26295	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D0Z67_RS26300	COG0121	glutamine amidotransferase
D0Z67_RS26305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0Z67_RS26320	COG0657	acetylesterase activity
D0Z67_RS26350	COG1609	Transcriptional regulator
D0Z67_RS26355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Z67_RS26360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Z67_RS26365	COG0242	peptide deformylase activity
D0Z67_RS26395	COG2409	Drug exporters of the RND superfamily
D0Z67_RS26400	COG1846	Transcriptional regulator
D0Z67_RS26405	COG1609	Transcriptional regulator
D0Z67_RS26420	COG0395	ABC-type sugar transport system, permease component
D0Z67_RS26440	COG0668	transmembrane transport
D0Z67_RS26465	COG0477	Major facilitator Superfamily
D0Z67_RS26490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Z67_RS26555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D0Z67_RS26560	COG4221	oxidoreductase activity
D0Z67_RS26565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Z67_RS26570	COG1755	Isoprenylcysteine carboxyl methyltransferase
D0Z67_RS26595	COG1175	transmembrane transport
D0Z67_RS26605	COG0456	acetyltransferase
D0Z67_RS26610	COG3876	Protein conserved in bacteria
D0Z67_RS26650	COG3251	PFAM MbtH domain protein
D0Z67_RS26680	COG5002	protein histidine kinase activity
D0Z67_RS26685	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS26725	COG0596	Alpha beta hydrolase
D0Z67_RS26735	COG0477	Major facilitator Superfamily
D0Z67_RS26740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D0Z67_RS26745	COG1902	pentaerythritol trinitrate reductase activity
D0Z67_RS26760	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS26775	COG2208	phosphoserine phosphatase activity
D0Z67_RS26775	COG2172	sigma factor antagonist activity
D0Z67_RS26775	COG1366	Belongs to the anti-sigma-factor antagonist family
D0Z67_RS26805	COG1902	pentaerythritol trinitrate reductase activity
D0Z67_RS26805	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Z67_RS26810	COG1309	transcriptional regulator
D0Z67_RS26835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0Z67_RS26850	COG1595	DNA-templated transcription, initiation
D0Z67_RS26870	COG2409	Drug exporters of the RND superfamily
D0Z67_RS26875	COG1335	isochorismatase
D0Z67_RS26900	COG3119	arylsulfatase activity
D0Z67_RS26910	COG0069	glutamate synthase activity
D0Z67_RS26915	COG0028	Belongs to the TPP enzyme family
D0Z67_RS26950	COG4251	negative regulation of phosphorylation
D0Z67_RS26970	COG0789	Transcriptional regulator
D0Z67_RS26980	COG5297	Belongs to the glycosyl hydrolase family 6
D0Z67_RS26995	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z67_RS27005	COG0583	DNA-binding transcription factor activity
D0Z67_RS27035	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D0Z67_RS27045	COG0823	Involved in the tonB-independent uptake of proteins
D0Z67_RS27060	COG1960	acyl-CoA dehydrogenase activity
D0Z67_RS27075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Z67_RS27100	COG2197	response regulator
D0Z67_RS27100	COG3903	Transcriptional regulator
D0Z67_RS27115	COG3629	intracellular signal transduction
D0Z67_RS27115	COG3903	Transcriptional regulator
D0Z67_RS27160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0Z67_RS27160	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS27160	COG3321	synthase
D0Z67_RS27160	COG4221	oxidoreductase activity
D0Z67_RS27175	COG0017	Asparaginyl-tRNA synthetase
D0Z67_RS27180	COG2226	methyltransferase
D0Z67_RS27195	COG0442	prolyl-tRNA aminoacylation
D0Z67_RS27230	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Z67_RS27235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0Z67_RS27275	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D0Z67_RS27290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D0Z67_RS27300	COG0656	L-ascorbic acid biosynthetic process
D0Z67_RS27315	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS27320	COG1191	sigma factor activity
D0Z67_RS27325	COG1309	transcriptional regulator
D0Z67_RS27340	COG4585	Histidine kinase
D0Z67_RS27345	COG2197	response regulator
D0Z67_RS27385	COG1278	Cold shock
D0Z67_RS27400	COG2814	Major facilitator Superfamily
D0Z67_RS27450	COG1309	transcriptional regulator
D0Z67_RS27470	COG0515	serine threonine protein kinase
D0Z67_RS27470	COG2815	serine threonine protein kinase
D0Z67_RS27480	COG2326	polyphosphate kinase activity
D0Z67_RS27500	COG4104	PAAR repeat-containing protein
D0Z67_RS27500	COG3209	COG3209 Rhs family protein
D0Z67_RS27525	COG1174	glycine betaine transport
D0Z67_RS27530	COG1174	glycine betaine transport
D0Z67_RS27545	COG1556	Lactate utilization protein
D0Z67_RS27550	COG1139	Iron-sulfur cluster binding protein
D0Z67_RS27555	COG0247	lactate metabolic process
D0Z67_RS27560	COG1357	PFAM Pentapeptide repeats (8 copies)
D0Z67_RS27570	COG1309	transcriptional regulator
D0Z67_RS27580	COG2706	6-phosphogluconolactonase activity
D0Z67_RS27615	COG1796	DNA polymerase
D0Z67_RS27615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0Z67_RS27640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0Z67_RS27665	COG2124	cytochrome p450
D0Z67_RS27715	COG2132	Multicopper oxidase
D0Z67_RS27810	COG1335	isochorismatase
D0Z67_RS27920	COG0572	uridine kinase
D0Z67_RS27945	COG3387	PFAM Glycoside hydrolase 15-related
D0Z67_RS27980	COG2264	protein methyltransferase activity
D0Z67_RS28000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Z67_RS28020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Z67_RS28025	COG0798	PFAM Bile acid sodium symporter
D0Z67_RS28030	COG0640	Transcriptional regulator
D0Z67_RS28040	COG0667	Aldo Keto reductase
D0Z67_RS28080	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D0Z67_RS28095	COG3469	chitinase activity
D0Z67_RS28140	COG0583	DNA-binding transcription factor activity
D0Z67_RS28165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0Z67_RS28175	COG2205	protein histidine kinase activity
D0Z67_RS28180	COG0745	RESPONSE REGULATOR receiver
D0Z67_RS28185	COG0477	Major facilitator Superfamily
D0Z67_RS28205	COG2124	cytochrome p450
D0Z67_RS28210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0Z67_RS28215	COG2340	Cysteine-rich secretory protein family
D0Z67_RS28265	COG0277	FAD linked oxidase domain protein
D0Z67_RS28270	COG1597	lipid kinase activity
D0Z67_RS28275	COG0438	transferase activity, transferring glycosyl groups
D0Z67_RS28285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D0Z67_RS28310	COG0542	response to heat
D0Z67_RS28325	COG0314	molybdopterin synthase activity
D0Z67_RS28340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0Z67_RS28345	COG1294	oxidase, subunit
D0Z67_RS28350	COG1271	oxidase subunit
D0Z67_RS28360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0Z67_RS28365	COG0583	DNA-binding transcription factor activity
D0Z67_RS28370	COG1289	transmembrane transporter activity
D0Z67_RS28375	COG2837	iron assimilation
D0Z67_RS28380	COG0076	glutamate decarboxylase activity
D0Z67_RS28385	COG0243	molybdopterin cofactor binding
D0Z67_RS28395	COG0542	response to heat
D0Z67_RS28420	COG1230	cation diffusion facilitator family transporter
D0Z67_RS28440	COG0243	molybdopterin cofactor binding
D0Z67_RS28445	COG1294	oxidase, subunit
D0Z67_RS28450	COG1271	oxidase subunit
D0Z67_RS28465	COG4977	sequence-specific DNA binding
D0Z67_RS28470	COG3629	intracellular signal transduction
D0Z67_RS28470	COG3903	Transcriptional regulator
D0Z67_RS28495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0Z67_RS28565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Z67_RS28580	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z67_RS28625	COG0628	permease
D0Z67_RS28635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Z67_RS28635	COG1024	Enoyl-CoA hydratase
D0Z67_RS28640	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D0Z67_RS28645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0Z67_RS28650	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D0Z67_RS28655	COG0298	carbon dioxide binding
D0Z67_RS28670	COG0375	protein maturation
D0Z67_RS28710	COG0586	Pfam SNARE associated Golgi protein
D0Z67_RS28720	COG0583	DNA-binding transcription factor activity
D0Z67_RS28725	COG5640	endopeptidase activity
D0Z67_RS28730	COG5640	endopeptidase activity
D0Z67_RS28805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Z67_RS28810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Z67_RS28825	COG1595	DNA-templated transcription, initiation
D0Z67_RS28865	COG1295	ribonuclease BN
D0Z67_RS28865	COG1959	2 iron, 2 sulfur cluster binding
D0Z67_RS28890	COG1609	Transcriptional regulator
D0Z67_RS28895	COG1879	ABC-type sugar transport system periplasmic component
D0Z67_RS28900	COG1129	ABC transporter
D0Z67_RS28905	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS28910	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0Z67_RS28930	COG1609	Transcriptional regulator
D0Z67_RS28950	COG1621	beta-fructofuranosidase activity
D0Z67_RS28955	COG2318	DinB family
D0Z67_RS29330	COG2197	response regulator
D0Z67_RS29345	COG0629	single-stranded DNA binding
D0Z67_RS29415	COG1475	DNA binding
D0Z67_RS29420	COG1192	Involved in chromosome partitioning
D0Z67_RS29540	COG0717	Belongs to the dCTP deaminase family