locus-tag	class	description
A7J05_RS00035	COG3293	Transposase
A7J05_RS00120	COG1595	DNA-templated transcription, initiation
A7J05_RS00190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS00195	COG1309	transcriptional regulator
A7J05_RS00205	COG3293	Transposase
A7J05_RS00250	COG3547	Transposase (IS116 IS110 IS902 family)
A7J05_RS00285	COG2175	clavaminate synthase activity
A7J05_RS00290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS00320	COG0527	aspartate kinase activity
A7J05_RS00345	COG2197	response regulator
A7J05_RS00355	COG3959	Transketolase, thiamine diphosphate binding domain
A7J05_RS00360	COG3958	Transketolase
A7J05_RS00370	COG3251	PFAM MbtH domain protein
A7J05_RS00395	COG3321	synthase
A7J05_RS00395	COG0604	alcohol dehydrogenase
A7J05_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS00415	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS00425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS00435	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS00465	COG3903	Transcriptional regulator
A7J05_RS00465	COG3629	intracellular signal transduction
A7J05_RS00470	COG2197	response regulator
A7J05_RS00485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J05_RS00500	COG0667	Aldo Keto reductase
A7J05_RS00520	COG0076	glutamate decarboxylase activity
A7J05_RS00535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS00545	COG2070	2-Nitropropane dioxygenase
A7J05_RS00585	COG0702	epimerase
A7J05_RS00590	COG2124	cytochrome p450
A7J05_RS00655	COG0477	Major facilitator Superfamily
A7J05_RS00675	COG2801	Transposase and inactivated derivatives
A7J05_RS00765	COG3293	Transposase
A7J05_RS00840	COG2508	Transcriptional regulator
A7J05_RS00855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS00865	COG2197	response regulator
A7J05_RS00870	COG0395	ABC-type sugar transport system, permease component
A7J05_RS00875	COG1175	transmembrane transport
A7J05_RS00880	COG1653	transport
A7J05_RS00905	COG0783	Belongs to the Dps family
A7J05_RS00910	COG2259	Doxx family
A7J05_RS00915	COG1335	isochorismatase
A7J05_RS00965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7J05_RS00970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7J05_RS00980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7J05_RS01005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J05_RS01045	COG2770	Histidine kinase
A7J05_RS01045	COG2208	phosphoserine phosphatase activity
A7J05_RS01080	COG0456	acetyltransferase
A7J05_RS01120	COG3321	synthase
A7J05_RS01120	COG0604	alcohol dehydrogenase
A7J05_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS01135	COG1309	transcriptional regulator
A7J05_RS01145	COG1131	(ABC) transporter
A7J05_RS01155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7J05_RS01230	COG2197	response regulator
A7J05_RS01235	COG4585	Histidine kinase
A7J05_RS01240	COG0577	efflux transmembrane transporter activity
A7J05_RS01250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7J05_RS01255	COG0583	DNA-binding transcription factor activity
A7J05_RS01405	COG0515	serine threonine protein kinase
A7J05_RS01405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7J05_RS01440	COG2208	phosphoserine phosphatase activity
A7J05_RS01440	COG2770	Histidine kinase
A7J05_RS01445	COG0596	Alpha beta hydrolase
A7J05_RS01475	COG2318	DinB family
A7J05_RS01480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7J05_RS01495	COG0667	Aldo Keto reductase
A7J05_RS01500	COG0789	Transcriptional regulator
A7J05_RS01520	COG0148	phosphopyruvate hydratase activity
A7J05_RS01525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7J05_RS01535	COG2066	Belongs to the glutaminase family
A7J05_RS01540	COG0583	DNA-binding transcription factor activity
A7J05_RS01595	COG0745	RESPONSE REGULATOR receiver
A7J05_RS01600	COG2205	protein histidine kinase activity
A7J05_RS01650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS01650	COG3321	synthase
A7J05_RS01650	COG4221	oxidoreductase activity
A7J05_RS01655	COG2175	clavaminate synthase activity
A7J05_RS01670	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS01690	COG4221	oxidoreductase activity
A7J05_RS01700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7J05_RS01705	COG2197	response regulator
A7J05_RS01715	COG0604	alcohol dehydrogenase
A7J05_RS01715	COG3321	synthase
A7J05_RS01730	COG0604	alcohol dehydrogenase
A7J05_RS01730	COG3321	synthase
A7J05_RS01740	COG0604	alcohol dehydrogenase
A7J05_RS01740	COG3321	synthase
A7J05_RS01755	COG3321	synthase
A7J05_RS01755	COG0604	alcohol dehydrogenase
A7J05_RS01765	COG0604	alcohol dehydrogenase
A7J05_RS01765	COG3321	synthase
A7J05_RS01775	COG3321	synthase
A7J05_RS01775	COG0604	alcohol dehydrogenase
A7J05_RS01785	COG0604	alcohol dehydrogenase
A7J05_RS01785	COG3321	synthase
A7J05_RS01820	COG0488	(ABC) transporter
A7J05_RS01880	COG0513	Belongs to the DEAD box helicase family
A7J05_RS01885	COG1278	Cold shock
A7J05_RS01895	COG0640	Transcriptional regulator
A7J05_RS01955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7J05_RS01980	COG0328	RNA-DNA hybrid ribonuclease activity
A7J05_RS02020	COG1191	sigma factor activity
A7J05_RS02025	COG1191	sigma factor activity
A7J05_RS02030	COG0784	Response regulator, receiver
A7J05_RS02035	COG4251	negative regulation of phosphorylation
A7J05_RS02050	COG3250	beta-galactosidase activity
A7J05_RS02060	COG2813	Specifically methylates the guanine in position
A7J05_RS02065	COG2318	DinB family
A7J05_RS02075	COG1131	(ABC) transporter
A7J05_RS02085	COG2197	response regulator
A7J05_RS02090	COG1191	sigma factor activity
A7J05_RS02115	COG0483	inositol monophosphate 1-phosphatase activity
A7J05_RS02140	COG2197	response regulator
A7J05_RS02185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J05_RS02195	COG4977	sequence-specific DNA binding
A7J05_RS02215	COG0596	Alpha beta hydrolase
A7J05_RS02220	COG1309	transcriptional regulator
A7J05_RS02245	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J05_RS02255	COG1309	transcriptional regulator
A7J05_RS02260	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS02285	COG2409	Drug exporters of the RND superfamily
A7J05_RS02315	COG0583	DNA-binding transcription factor activity
A7J05_RS02340	COG2326	polyphosphate kinase activity
A7J05_RS02345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A7J05_RS02360	COG0596	Alpha beta hydrolase
A7J05_RS02390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A7J05_RS02410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7J05_RS02415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J05_RS02445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7J05_RS02465	COG0583	DNA-binding transcription factor activity
A7J05_RS02475	COG2080	2 iron, 2 sulfur cluster binding
A7J05_RS02480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A7J05_RS02485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7J05_RS02490	COG1796	DNA polymerase
A7J05_RS02490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7J05_RS02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J05_RS02515	COG2124	cytochrome p450
A7J05_RS02535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7J05_RS02545	COG0583	DNA-binding transcription factor activity
A7J05_RS02570	COG3321	synthase
A7J05_RS02570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS02570	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS02570	COG0300	oxidoreductase activity
A7J05_RS02575	COG3321	synthase
A7J05_RS02575	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS02575	COG4221	oxidoreductase activity
A7J05_RS02575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS02590	COG3321	synthase
A7J05_RS02590	COG0300	oxidoreductase activity
A7J05_RS02590	COG4221	oxidoreductase activity
A7J05_RS02590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS02600	COG3321	synthase
A7J05_RS02600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS02600	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS02600	COG0300	oxidoreductase activity
A7J05_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS02605	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J05_RS02620	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS02635	COG0477	Major facilitator Superfamily
A7J05_RS02640	COG1957	nucleoside hydrolase
A7J05_RS02670	COG0477	Major facilitator Superfamily
A7J05_RS02705	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A7J05_RS02710	COG2814	Major facilitator Superfamily
A7J05_RS02715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7J05_RS02730	COG1228	amidohydrolase
A7J05_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS02750	COG0512	Glutamine amidotransferase of anthranilate synthase
A7J05_RS02770	COG0477	Major facilitator Superfamily
A7J05_RS02790	COG0583	DNA-binding transcription factor activity
A7J05_RS02800	COG1595	DNA-templated transcription, initiation
A7J05_RS02825	COG1609	Transcriptional regulator
A7J05_RS02830	COG3250	beta-galactosidase activity
A7J05_RS02840	COG1175	transmembrane transport
A7J05_RS02845	COG3833	ABC-type maltose transport systems, permease component
A7J05_RS02875	COG0531	amino acid
A7J05_RS02920	COG0494	nUDIX hydrolase
A7J05_RS02960	COG0789	Transcriptional regulator
A7J05_RS02980	COG0778	Nitroreductase
A7J05_RS03000	COG1309	transcriptional regulator
A7J05_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS03065	COG0107	imidazoleglycerol-phosphate synthase activity
A7J05_RS03080	COG2197	response regulator
A7J05_RS03085	COG1129	ABC transporter
A7J05_RS03090	COG1120	ATPase activity
A7J05_RS03095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS03110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS03120	COG3547	Transposase (IS116 IS110 IS902 family)
A7J05_RS03160	COG1404	Belongs to the peptidase S8 family
A7J05_RS03175	COG2271	Major facilitator Superfamily
A7J05_RS03195	COG2226	methyltransferase
A7J05_RS03205	COG1595	DNA-templated transcription, initiation
A7J05_RS03265	COG1819	glycosyl
A7J05_RS03270	COG0789	Transcriptional regulator
A7J05_RS03275	COG0823	Involved in the tonB-independent uptake of proteins
A7J05_RS03295	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7J05_RS03330	COG3293	Transposase
A7J05_RS03340	COG2124	cytochrome p450
A7J05_RS03350	COG3424	synthase
A7J05_RS03395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS03405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS03410	COG0066	3-isopropylmalate dehydratase activity
A7J05_RS03415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7J05_RS03425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7J05_RS03440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS03440	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A7J05_RS03455	COG2197	response regulator
A7J05_RS03460	COG0017	Asparaginyl-tRNA synthetase
A7J05_RS03480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS03485	COG0702	epimerase
A7J05_RS03500	COG3590	peptidase
A7J05_RS03540	COG1132	(ABC) transporter
A7J05_RS03545	COG1309	transcriptional regulator
A7J05_RS03560	COG0435	Glutathione S-transferase
A7J05_RS03595	COG2706	6-phosphogluconolactonase activity
A7J05_RS03625	COG0386	Belongs to the glutathione peroxidase family
A7J05_RS03630	COG1686	Belongs to the peptidase S11 family
A7J05_RS03635	COG0673	inositol 2-dehydrogenase activity
A7J05_RS03640	COG1295	ribonuclease BN
A7J05_RS03650	COG1793	dna ligase
A7J05_RS03680	COG0181	hydroxymethylbilane synthase activity
A7J05_RS03700	COG0366	Alpha amylase catalytic
A7J05_RS03705	COG3833	ABC-type maltose transport systems, permease component
A7J05_RS03710	COG1175	transmembrane transport
A7J05_RS03720	COG1609	Transcriptional regulator
A7J05_RS03740	COG1131	(ABC) transporter
A7J05_RS03765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7J05_RS03780	COG0561	phosphatase activity
A7J05_RS03790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7J05_RS03795	COG0662	Cupin 2, conserved barrel domain protein
A7J05_RS03820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J05_RS03830	COG4989	oxidoreductase activity
A7J05_RS03840	COG2814	Major facilitator Superfamily
A7J05_RS03855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7J05_RS03945	COG1024	Enoyl-CoA hydratase
A7J05_RS03955	COG1605	Chorismate mutase
A7J05_RS03960	COG2267	carboxylic ester hydrolase activity
A7J05_RS03970	COG3033	Beta-eliminating lyase
A7J05_RS04005	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS04010	COG2366	antibiotic biosynthetic process
A7J05_RS04020	COG2070	2-Nitropropane dioxygenase
A7J05_RS04025	COG0789	Transcriptional regulator
A7J05_RS04035	COG2815	serine threonine protein kinase
A7J05_RS04035	COG0515	serine threonine protein kinase
A7J05_RS04045	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS04100	COG2267	carboxylic ester hydrolase activity
A7J05_RS04125	COG0456	acetyltransferase
A7J05_RS04140	COG4948	Mandelate Racemase Muconate Lactonizing
A7J05_RS04160	COG1064	alcohol dehydrogenase
A7J05_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS04190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A7J05_RS04195	COG1982	Orn Lys Arg decarboxylase major
A7J05_RS04225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7J05_RS04230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7J05_RS04245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7J05_RS04250	COG1609	Transcriptional regulator
A7J05_RS04265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A7J05_RS04270	COG0121	glutamine amidotransferase
A7J05_RS04275	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A7J05_RS04280	COG2182	Extracellular solute-binding protein
A7J05_RS04290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS04295	COG0577	efflux transmembrane transporter activity
A7J05_RS04295	COG1136	(ABC) transporter
A7J05_RS04300	COG0577	efflux transmembrane transporter activity
A7J05_RS04300	COG1136	(ABC) transporter
A7J05_RS04320	COG2124	cytochrome p450
A7J05_RS04325	COG2124	cytochrome p450
A7J05_RS04330	COG2124	cytochrome p450
A7J05_RS04335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS04360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS04365	COG2205	protein histidine kinase activity
A7J05_RS04370	COG1132	(ABC) transporter
A7J05_RS04385	COG1024	Enoyl-CoA hydratase
A7J05_RS04390	COG1024	Enoyl-CoA hydratase
A7J05_RS04395	COG3424	synthase
A7J05_RS04405	COG1304	FMN binding
A7J05_RS04430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7J05_RS04435	COG1053	succinate dehydrogenase
A7J05_RS04445	COG0583	DNA-binding transcription factor activity
A7J05_RS04510	COG0531	amino acid
A7J05_RS04525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7J05_RS04540	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A7J05_RS04550	COG0745	RESPONSE REGULATOR receiver
A7J05_RS04565	COG3618	amidohydrolase
A7J05_RS04585	COG0395	ABC-type sugar transport system, permease component
A7J05_RS04590	COG1175	transmembrane transport
A7J05_RS04620	COG3250	beta-galactosidase activity
A7J05_RS04625	COG1609	Transcriptional regulator
A7J05_RS04630	COG1879	ABC-type sugar transport system periplasmic component
A7J05_RS04635	COG1129	ABC transporter
A7J05_RS04640	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS04645	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS04650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7J05_RS04655	COG0297	glycogen (starch) synthase activity
A7J05_RS04675	COG3458	cephalosporin-C deacetylase activity
A7J05_RS04700	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A7J05_RS04710	COG0463	Glycosyl transferase, family 2
A7J05_RS04710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7J05_RS04715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7J05_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS04810	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A7J05_RS04820	COG1063	alcohol dehydrogenase
A7J05_RS04845	COG1132	(ABC) transporter
A7J05_RS04895	COG2890	protein-(glutamine-N5) methyltransferase activity
A7J05_RS04925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS04930	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A7J05_RS04940	COG3655	Transcriptional regulator
A7J05_RS04945	COG2353	YceI-like domain
A7J05_RS04965	COG2197	response regulator
A7J05_RS04975	COG1222	aaa ATPase
A7J05_RS05075	COG1136	(ABC) transporter
A7J05_RS05090	COG2197	response regulator
A7J05_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS05125	COG1309	transcriptional regulator
A7J05_RS05165	COG0183	Belongs to the thiolase family
A7J05_RS05180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7J05_RS05200	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS05210	COG0673	inositol 2-dehydrogenase activity
A7J05_RS05220	COG0395	ABC-type sugar transport system, permease component
A7J05_RS05225	COG1175	transmembrane transport
A7J05_RS05245	COG0668	transmembrane transport
A7J05_RS05270	COG3540	Alkaline phosphatase
A7J05_RS05300	COG2267	carboxylic ester hydrolase activity
A7J05_RS05320	COG1396	sequence-specific DNA binding
A7J05_RS05325	COG1116	anion transmembrane transporter activity
A7J05_RS05335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7J05_RS05340	COG0583	DNA-binding transcription factor activity
A7J05_RS05345	COG0156	8-amino-7-oxononanoate synthase activity
A7J05_RS05350	COG1063	alcohol dehydrogenase
A7J05_RS05355	COG0673	inositol 2-dehydrogenase activity
A7J05_RS05390	COG2755	lipolytic protein G-D-S-L family
A7J05_RS05400	COG2365	Tyrosine phosphatase family
A7J05_RS05420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7J05_RS05425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7J05_RS05440	COG1657	PFAM Prenyltransferase squalene oxidase
A7J05_RS05450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A7J05_RS05460	COG1562	ergosterol biosynthetic process
A7J05_RS05465	COG1134	teichoic acid transport
A7J05_RS05515	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7J05_RS05525	COG1024	Enoyl-CoA hydratase
A7J05_RS05535	COG4977	sequence-specific DNA binding
A7J05_RS05550	COG2183	response to ionizing radiation
A7J05_RS05555	COG0488	(ABC) transporter
A7J05_RS05565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7J05_RS05575	COG2936	dipeptidyl-peptidase activity
A7J05_RS05585	COG1113	amino acid transport
A7J05_RS05600	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J05_RS05600	COG1024	Enoyl-CoA hydratase
A7J05_RS05605	COG0183	Belongs to the thiolase family
A7J05_RS05610	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS05615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J05_RS05620	COG1683	Conserved Protein
A7J05_RS05625	COG3268	Saccharopine dehydrogenase
A7J05_RS05635	COG1515	deoxyribonuclease V activity
A7J05_RS05645	COG2268	Band 7 protein
A7J05_RS05665	COG0488	(ABC) transporter
A7J05_RS05670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7J05_RS05675	COG1834	amidinotransferase
A7J05_RS05765	COG1793	dna ligase
A7J05_RS05775	COG1470	cell adhesion involved in biofilm formation
A7J05_RS05780	COG1595	DNA-templated transcription, initiation
A7J05_RS05785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS05800	COG1024	Enoyl-CoA hydratase
A7J05_RS05825	COG0183	Belongs to the thiolase family
A7J05_RS05830	COG1309	transcriptional regulator
A7J05_RS05840	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS05845	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS05850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A7J05_RS05880	COG0525	valine-tRNA ligase activity
A7J05_RS05885	COG0525	valine-tRNA ligase activity
A7J05_RS05905	COG0525	valine-tRNA ligase activity
A7J05_RS05910	COG3511	phospholipase C
A7J05_RS05915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7J05_RS05930	COG1486	melibiose metabolic process
A7J05_RS05940	COG0477	Major facilitator Superfamily
A7J05_RS05950	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J05_RS05955	COG3246	L-lysine catabolic process to acetate
A7J05_RS05985	COG1136	(ABC) transporter
A7J05_RS05985	COG0577	efflux transmembrane transporter activity
A7J05_RS06050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7J05_RS06055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A7J05_RS06065	COG0583	DNA-binding transcription factor activity
A7J05_RS06085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS06110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7J05_RS06135	COG1063	alcohol dehydrogenase
A7J05_RS06140	COG1472	Belongs to the glycosyl hydrolase 3 family
A7J05_RS06150	COG2223	nitrite transmembrane transporter activity
A7J05_RS06160	COG2207	Transcriptional regulator
A7J05_RS06165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7J05_RS06185	COG3938	Belongs to the proline racemase family
A7J05_RS06230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7J05_RS06260	COG1879	ABC-type sugar transport system periplasmic component
A7J05_RS06265	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS06270	COG1129	ABC transporter
A7J05_RS06275	COG1940	carbohydrate kinase activity
A7J05_RS06290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS06295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A7J05_RS06330	COG0656	L-ascorbic acid biosynthetic process
A7J05_RS06345	COG2226	methyltransferase
A7J05_RS06350	COG2154	pterin-4-alpha-carbinolamine dehydratase
A7J05_RS06370	COG1140	nitrate reductase beta subunit
A7J05_RS06385	COG0443	Heat shock 70 kDa protein
A7J05_RS06395	COG0531	amino acid
A7J05_RS06440	COG0028	Belongs to the TPP enzyme family
A7J05_RS06445	COG0248	Ppx GppA phosphatase
A7J05_RS06460	COG0488	(ABC) transporter
A7J05_RS06470	COG2226	methyltransferase
A7J05_RS06525	COG3285	dna ligase
A7J05_RS06525	COG1793	dna ligase
A7J05_RS06560	COG0326	Molecular chaperone. Has ATPase activity
A7J05_RS06585	COG1619	proteins homologs of microcin C7 resistance protein MccF
A7J05_RS06595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J05_RS06600	COG2362	D-Aminopeptidase
A7J05_RS06610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7J05_RS06625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS06630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7J05_RS06640	COG3386	PFAM SMP-30 Gluconolaconase
A7J05_RS06645	COG1414	Transcriptional regulator
A7J05_RS06675	COG4214	carbohydrate transport
A7J05_RS06705	COG1595	DNA-templated transcription, initiation
A7J05_RS06710	COG1501	Belongs to the glycosyl hydrolase 31 family
A7J05_RS06725	COG4209	transmembrane transport
A7J05_RS06730	COG0395	ABC-type sugar transport system, permease component
A7J05_RS06745	COG5297	Belongs to the glycosyl hydrolase family 6
A7J05_RS06760	COG3866	Pectate lyase
A7J05_RS06765	COG2755	lipolytic protein G-D-S-L family
A7J05_RS06770	COG1653	transport
A7J05_RS06790	COG0395	ABC-type sugar transport system, permease component
A7J05_RS06805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J05_RS06810	COG1802	Transcriptional regulator
A7J05_RS06820	COG2208	phosphoserine phosphatase activity
A7J05_RS06820	COG2172	sigma factor antagonist activity
A7J05_RS06820	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J05_RS06855	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J05_RS06865	COG0604	alcohol dehydrogenase
A7J05_RS06870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7J05_RS06870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7J05_RS06875	COG2301	Belongs to the HpcH HpaI aldolase family
A7J05_RS06885	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS06890	COG0688	phosphatidylethanolamine metabolic process
A7J05_RS06905	COG0559	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS06910	COG0559	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS06920	COG0410	ABC transporter
A7J05_RS06930	COG1929	Belongs to the glycerate kinase type-1 family
A7J05_RS06940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7J05_RS06960	COG0483	inositol monophosphate 1-phosphatase activity
A7J05_RS06995	COG1140	nitrate reductase beta subunit
A7J05_RS07005	COG2181	nitrate reductase activity
A7J05_RS07020	COG1017	nitric oxide dioxygenase activity
A7J05_RS07020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7J05_RS07030	COG0702	epimerase
A7J05_RS07050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7J05_RS07055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS07075	COG0405	Gamma-glutamyltransferase
A7J05_RS07130	COG3387	PFAM Glycoside hydrolase 15-related
A7J05_RS07160	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS07210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7J05_RS07400	COG0738	Major facilitator superfamily
A7J05_RS07405	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7J05_RS07535	COG0142	geranyltranstransferase activity
A7J05_RS07560	COG2175	clavaminate synthase activity
A7J05_RS07655	COG0243	molybdopterin cofactor binding
A7J05_RS07785	COG0159	tryptophan synthase activity
A7J05_RS07845	COG1857	crispr-associated protein
A7J05_RS07860	COG1518	maintenance of DNA repeat elements
A7J05_RS07865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7J05_RS07880	COG1376	ErfK ybiS ycfS ynhG family protein
A7J05_RS07890	COG0765	amino acid transport
A7J05_RS07895	COG0765	amino acid transport
A7J05_RS07900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J05_RS07905	COG1126	abc transporter atp-binding protein
A7J05_RS07930	COG1131	(ABC) transporter
A7J05_RS07935	COG3851	Histidine kinase
A7J05_RS07940	COG2197	response regulator
A7J05_RS07960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS07975	COG1940	carbohydrate kinase activity
A7J05_RS07980	COG1129	ABC transporter
A7J05_RS07985	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS08000	COG2188	Transcriptional regulator
A7J05_RS08005	COG0673	inositol 2-dehydrogenase activity
A7J05_RS08015	COG2197	response regulator
A7J05_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS08040	COG4266	Belongs to the allantoicase family
A7J05_RS08045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7J05_RS08050	COG1414	Transcriptional regulator
A7J05_RS08055	COG1136	(ABC) transporter
A7J05_RS08060	COG0577	efflux transmembrane transporter activity
A7J05_RS08065	COG4585	Histidine kinase
A7J05_RS08080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J05_RS08095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A7J05_RS08110	COG0436	Aminotransferase
A7J05_RS08130	COG0588	phosphoglycerate mutase activity
A7J05_RS08145	COG2356	endonuclease I
A7J05_RS08175	COG0534	Mate efflux family protein
A7J05_RS08205	COG2233	PERMEase
A7J05_RS08215	COG2233	PERMEase
A7J05_RS08225	COG2351	hydroxyisourate hydrolase activity
A7J05_RS08245	COG3622	Belongs to the hyi family
A7J05_RS08250	COG2084	Dehydrogenase
A7J05_RS08255	COG0753	catalase activity
A7J05_RS08260	COG3960	tartronate-semialdehyde synthase activity
A7J05_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS08280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7J05_RS08285	COG2197	response regulator
A7J05_RS08295	COG0598	Magnesium transport protein CorA
A7J05_RS08385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS08400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7J05_RS08450	COG2197	response regulator
A7J05_RS08470	COG0542	response to heat
A7J05_RS08475	COG0753	catalase activity
A7J05_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS08505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A7J05_RS08510	COG4221	oxidoreductase activity
A7J05_RS08520	COG0859	PFAM glycosyl transferase family 9
A7J05_RS08525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7J05_RS08525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7J05_RS08530	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7J05_RS08535	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS08545	COG0859	PFAM glycosyl transferase family 9
A7J05_RS08550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7J05_RS08560	COG2192	nodulation
A7J05_RS08565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7J05_RS08575	COG3594	Acyltransferase
A7J05_RS08580	COG0076	glutamate decarboxylase activity
A7J05_RS08625	COG2252	PERMEase
A7J05_RS08630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7J05_RS08650	COG3835	regulator
A7J05_RS08660	COG1802	Transcriptional regulator
A7J05_RS08685	COG0028	Belongs to the TPP enzyme family
A7J05_RS08730	COG2226	methyltransferase
A7J05_RS08735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7J05_RS08740	COG2124	cytochrome p450
A7J05_RS08785	COG0494	nUDIX hydrolase
A7J05_RS08815	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS08830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7J05_RS08840	COG0175	sulfate reduction
A7J05_RS08845	COG0529	Catalyzes the synthesis of activated sulfate
A7J05_RS08865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A7J05_RS08870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7J05_RS08990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7J05_RS09000	COG0504	CTP synthase activity
A7J05_RS09030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7J05_RS09035	COG0443	Heat shock 70 kDa protein
A7J05_RS09090	COG1129	ABC transporter
A7J05_RS09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J05_RS09105	COG1869	D-ribose catabolic process
A7J05_RS09110	COG2234	aminopeptidase activity
A7J05_RS09110	COG4935	Belongs to the peptidase S8 family
A7J05_RS09115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J05_RS09120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7J05_RS09150	COG2226	methyltransferase
A7J05_RS09160	COG2267	carboxylic ester hydrolase activity
A7J05_RS09185	COG1116	anion transmembrane transporter activity
A7J05_RS09200	COG3220	belongs to the UPF0276 family
A7J05_RS09220	COG0596	Alpha beta hydrolase
A7J05_RS09225	COG3253	May function as heme-dependent peroxidase
A7J05_RS09230	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A7J05_RS09240	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7J05_RS09250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7J05_RS09265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A7J05_RS09270	COG0183	Belongs to the thiolase family
A7J05_RS09275	COG1024	Enoyl-CoA hydratase
A7J05_RS09275	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J05_RS09310	COG2843	Capsule synthesis protein
A7J05_RS09325	COG0531	amino acid
A7J05_RS09330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7J05_RS09335	COG4214	carbohydrate transport
A7J05_RS09345	COG4213	ABC transporter substrate-binding protein
A7J05_RS09355	COG0515	serine threonine protein kinase
A7J05_RS09355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7J05_RS09370	COG0395	ABC-type sugar transport system, permease component
A7J05_RS09380	COG2182	Extracellular solute-binding protein
A7J05_RS09385	COG0395	ABC-type sugar transport system, permease component
A7J05_RS09390	COG1175	transmembrane transport
A7J05_RS09445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7J05_RS09450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7J05_RS09475	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS09495	COG1024	Enoyl-CoA hydratase
A7J05_RS09505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7J05_RS09510	COG2235	arginine
A7J05_RS09515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7J05_RS09555	COG0346	lactoylglutathione lyase activity
A7J05_RS09560	COG1799	cell septum assembly
A7J05_RS09565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7J05_RS09580	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A7J05_RS09620	COG2124	cytochrome p450
A7J05_RS09650	COG0477	Major facilitator Superfamily
A7J05_RS09670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7J05_RS09685	COG1533	DNA photolyase activity
A7J05_RS09700	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A7J05_RS09720	COG0367	asparagine synthase
A7J05_RS09745	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS09755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A7J05_RS09770	COG4310	Domain of unknown function (DUF2172)
A7J05_RS09780	COG1215	transferase activity, transferring glycosyl groups
A7J05_RS09795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7J05_RS09865	COG4608	Belongs to the ABC transporter superfamily
A7J05_RS09870	COG0444	Belongs to the ABC transporter superfamily
A7J05_RS09890	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS09940	COG4974	Belongs to the 'phage' integrase family
A7J05_RS09965	COG0482	sulfurtransferase activity
A7J05_RS09980	COG1104	cysteine desulfurase activity
A7J05_RS09985	COG1061	Type III restriction enzyme res subunit
A7J05_RS10035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7J05_RS10040	COG0531	amino acid
A7J05_RS10060	COG0569	domain protein
A7J05_RS10090	COG1136	(ABC) transporter
A7J05_RS10090	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7J05_RS10095	COG1136	(ABC) transporter
A7J05_RS10115	COG0756	dUTP diphosphatase activity
A7J05_RS10140	COG2205	protein histidine kinase activity
A7J05_RS10145	COG0745	RESPONSE REGULATOR receiver
A7J05_RS10155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7J05_RS10190	COG1435	thymidine kinase activity
A7J05_RS10210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J05_RS10225	COG0612	Peptidase, M16
A7J05_RS10230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7J05_RS10250	COG0372	Belongs to the citrate synthase family
A7J05_RS10265	COG3290	protein histidine kinase activity
A7J05_RS10270	COG4565	transcriptional regulatory protein
A7J05_RS10275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J05_RS10285	COG0187	DNA topoisomerase II activity
A7J05_RS10300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7J05_RS10305	COG2186	Transcriptional regulator
A7J05_RS10310	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7J05_RS10330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7J05_RS10350	COG2382	esterase
A7J05_RS10355	COG1132	(ABC) transporter
A7J05_RS10365	COG1132	(ABC) transporter
A7J05_RS10375	COG1120	ATPase activity
A7J05_RS10380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS10385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS10390	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A7J05_RS10415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7J05_RS10465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7J05_RS10470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7J05_RS10475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7J05_RS10515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7J05_RS10525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7J05_RS10530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7J05_RS10540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7J05_RS10555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7J05_RS10565	COG2205	protein histidine kinase activity
A7J05_RS10575	COG1126	abc transporter atp-binding protein
A7J05_RS10585	COG0765	amino acid transport
A7J05_RS10590	COG0765	amino acid transport
A7J05_RS10605	COG2897	thiosulfate sulfurtransferase activity
A7J05_RS10625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7J05_RS10630	COG0628	permease
A7J05_RS10645	COG1201	RNA secondary structure unwinding
A7J05_RS10650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7J05_RS10660	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS10670	COG0783	Belongs to the Dps family
A7J05_RS10675	COG1396	sequence-specific DNA binding
A7J05_RS10680	COG1546	Belongs to the CinA family
A7J05_RS10680	COG1058	Belongs to the CinA family
A7J05_RS10690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7J05_RS10700	COG1674	ftsk spoiiie
A7J05_RS10710	COG2205	protein histidine kinase activity
A7J05_RS10710	COG4999	Histidine kinase
A7J05_RS10710	COG3850	Histidine kinase
A7J05_RS10710	COG3437	response regulator, receiver
A7J05_RS10720	COG2208	phosphoserine phosphatase activity
A7J05_RS10720	COG2770	Histidine kinase
A7J05_RS10760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A7J05_RS10765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J05_RS10770	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A7J05_RS10790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7J05_RS10795	COG0612	Peptidase, M16
A7J05_RS10800	COG1185	polyribonucleotide nucleotidyltransferase activity
A7J05_RS10805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7J05_RS10840	COG1404	Belongs to the peptidase S8 family
A7J05_RS10860	COG0455	bacterial-type flagellum organization
A7J05_RS10865	COG4166	transmembrane transport
A7J05_RS10870	COG0601	transmembrane transport
A7J05_RS10875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS10880	COG0444	Belongs to the ABC transporter superfamily
A7J05_RS10885	COG4608	Belongs to the ABC transporter superfamily
A7J05_RS10900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7J05_RS10905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7J05_RS10915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7J05_RS10930	COG0779	Required for maturation of 30S ribosomal subunits
A7J05_RS10945	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
A7J05_RS10950	COG0442	prolyl-tRNA aminoacylation
A7J05_RS10965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7J05_RS10970	COG0750	zinc metalloprotease
A7J05_RS10975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7J05_RS10985	COG0300	oxidoreductase activity
A7J05_RS10990	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS10995	COG2508	Transcriptional regulator
A7J05_RS10995	COG2508	Transcriptional regulator
A7J05_RS11025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS11030	COG1177	transmembrane transport
A7J05_RS11035	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7J05_RS11040	COG3842	ATPase activity
A7J05_RS11050	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS11065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7J05_RS11100	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS11110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7J05_RS11115	COG1136	(ABC) transporter
A7J05_RS11140	COG3842	ATPase activity
A7J05_RS11155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7J05_RS11160	COG0575	Belongs to the CDS family
A7J05_RS11165	COG0233	cytoplasmic translational termination
A7J05_RS11170	COG0528	UMP kinase activity
A7J05_RS11175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7J05_RS11180	COG0052	Belongs to the universal ribosomal protein uS2 family
A7J05_RS11185	COG4942	peptidase
A7J05_RS11195	COG1191	sigma factor activity
A7J05_RS11210	COG0792	nuclease activity
A7J05_RS11220	COG1051	belongs to the nudix hydrolase family
A7J05_RS11230	COG0681	Belongs to the peptidase S26 family
A7J05_RS11245	COG0335	large ribosomal subunit rRNA binding
A7J05_RS11250	COG0336	Belongs to the RNA methyltransferase TrmD family
A7J05_RS11255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7J05_RS11260	COG1837	Belongs to the UPF0109 family
A7J05_RS11265	COG0228	four-way junction DNA binding
A7J05_RS11280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7J05_RS11290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7J05_RS11320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7J05_RS11330	COG0477	Major facilitator Superfamily
A7J05_RS11335	COG1196	nuclear chromosome segregation
A7J05_RS11345	COG1254	Belongs to the acylphosphatase family
A7J05_RS11355	COG1733	regulation of RNA biosynthetic process
A7J05_RS11360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7J05_RS11365	COG0571	ribonuclease III activity
A7J05_RS11370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7J05_RS11385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7J05_RS11390	COG0742	ribosomal rna small subunit methyltransferase
A7J05_RS11400	COG1461	Dihydroxyacetone kinase
A7J05_RS11405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7J05_RS11420	COG0351	phosphomethylpyrimidine kinase
A7J05_RS11440	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7J05_RS11445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7J05_RS11455	COG1920	GTP binding
A7J05_RS11460	COG0066	3-isopropylmalate dehydratase activity
A7J05_RS11465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7J05_RS11470	COG1414	Transcriptional regulator
A7J05_RS11510	COG1011	Hydrolase
A7J05_RS11515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7J05_RS11520	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7J05_RS11535	COG2018	Roadblock/LC7 domain
A7J05_RS11555	COG2018	Roadblock/LC7 domain
A7J05_RS11585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J05_RS11610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7J05_RS11630	COG2957	Belongs to the agmatine deiminase family
A7J05_RS11635	COG0804	urea catabolic process
A7J05_RS11640	COG0832	Belongs to the urease beta subunit family
A7J05_RS11640	COG0831	urea catabolic process
A7J05_RS11655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS11660	COG0473	3-isopropylmalate dehydrogenase activity
A7J05_RS11685	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS11690	COG0506	proline dehydrogenase activity
A7J05_RS11695	COG3835	regulator
A7J05_RS11710	COG0477	Major facilitator Superfamily
A7J05_RS11715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7J05_RS11720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7J05_RS11725	COG0440	acetolactate synthase activity
A7J05_RS11750	COG0667	Aldo Keto reductase
A7J05_RS11765	COG2197	response regulator
A7J05_RS11780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7J05_RS11785	COG2409	Drug exporters of the RND superfamily
A7J05_RS11795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7J05_RS11805	COG0154	amidase activity
A7J05_RS11810	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7J05_RS11820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7J05_RS11830	COG4221	oxidoreductase activity
A7J05_RS11845	COG0482	sulfurtransferase activity
A7J05_RS11880	COG2860	membrane
A7J05_RS11885	COG4608	Belongs to the ABC transporter superfamily
A7J05_RS11890	COG0444	Belongs to the ABC transporter superfamily
A7J05_RS11895	COG0601	transmembrane transport
A7J05_RS11900	COG4166	transmembrane transport
A7J05_RS11905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS11925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7J05_RS11930	COG0509	glycine decarboxylation via glycine cleavage system
A7J05_RS11935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7J05_RS11940	COG1760	l-serine dehydratase
A7J05_RS11950	COG1119	ATPase activity
A7J05_RS11955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7J05_RS11960	COG2186	Transcriptional regulator
A7J05_RS11980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7J05_RS12015	COG1376	ErfK ybiS ycfS ynhG family protein
A7J05_RS12040	COG1132	(ABC) transporter
A7J05_RS12045	COG1132	(ABC) transporter
A7J05_RS12060	COG0058	SHG alpha-glucan phosphorylase activity
A7J05_RS12065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7J05_RS12065	COG0515	serine threonine protein kinase
A7J05_RS12075	COG0366	Alpha amylase catalytic
A7J05_RS12090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7J05_RS12095	COG3973	AAA domain
A7J05_RS12095	COG3973	AAA domain
A7J05_RS12100	COG3118	belongs to the thioredoxin family
A7J05_RS12100	COG0492	ferredoxin-NADP+ reductase activity
A7J05_RS12130	COG0477	Major facilitator Superfamily
A7J05_RS12140	COG1301	dicarboxylic acid transport
A7J05_RS12145	COG3290	protein histidine kinase activity
A7J05_RS12150	COG4565	transcriptional regulatory protein
A7J05_RS12160	COG1175	transmembrane transport
A7J05_RS12165	COG0395	ABC-type sugar transport system, permease component
A7J05_RS12170	COG0515	serine threonine protein kinase
A7J05_RS12180	COG0205	6-phosphofructokinase activity
A7J05_RS12185	COG0280	phosphate acetyltransferase
A7J05_RS12185	COG0857	belongs to the CobB CobQ family
A7J05_RS12190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7J05_RS12235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7J05_RS12235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7J05_RS12295	COG2205	protein histidine kinase activity
A7J05_RS12300	COG0745	RESPONSE REGULATOR receiver
A7J05_RS12315	COG0183	Belongs to the thiolase family
A7J05_RS12370	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A7J05_RS12385	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J05_RS12415	COG3850	Histidine kinase
A7J05_RS12420	COG2197	response regulator
A7J05_RS12435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7J05_RS12440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7J05_RS12445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7J05_RS12450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7J05_RS12455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7J05_RS12460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7J05_RS12465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7J05_RS12485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7J05_RS12490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7J05_RS12500	COG2890	protein-(glutamine-N5) methyltransferase activity
A7J05_RS12505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7J05_RS12510	COG0254	rRNA binding
A7J05_RS12525	COG0083	homoserine kinase activity
A7J05_RS12535	COG0019	diaminopimelate decarboxylase activity
A7J05_RS12545	COG0018	arginyl-trna synthetase
A7J05_RS12590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS12605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS12610	COG2814	Major facilitator Superfamily
A7J05_RS12620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A7J05_RS12630	COG1793	dna ligase
A7J05_RS12650	COG2205	protein histidine kinase activity
A7J05_RS12660	COG0772	Belongs to the SEDS family
A7J05_RS12665	COG0768	penicillin binding
A7J05_RS12735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7J05_RS12755	COG0745	RESPONSE REGULATOR receiver
A7J05_RS12760	COG2205	protein histidine kinase activity
A7J05_RS12765	COG0567	Dehydrogenase, E1 component
A7J05_RS12765	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7J05_RS12815	COG0765	amino acid transport
A7J05_RS12820	COG1126	abc transporter atp-binding protein
A7J05_RS12825	COG4106	trans-aconitate 2-methyltransferase activity
A7J05_RS12855	COG2197	response regulator
A7J05_RS12880	COG1011	Hydrolase
A7J05_RS12900	COG0142	geranyltranstransferase activity
A7J05_RS12905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7J05_RS12920	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A7J05_RS12935	COG2172	sigma factor antagonist activity
A7J05_RS12950	COG1597	lipid kinase activity
A7J05_RS12965	COG1309	transcriptional regulator
A7J05_RS12970	COG0363	glucosamine-6-phosphate deaminase activity
A7J05_RS12975	COG1472	Belongs to the glycosyl hydrolase 3 family
A7J05_RS12980	COG0395	ABC-type sugar transport system, permease component
A7J05_RS12985	COG1175	transmembrane transport
A7J05_RS12990	COG2182	Extracellular solute-binding protein
A7J05_RS12995	COG2188	Transcriptional regulator
A7J05_RS13000	COG1966	Carbon starvation protein
A7J05_RS13025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7J05_RS13030	COG2124	cytochrome p450
A7J05_RS13040	COG0242	peptide deformylase activity
A7J05_RS13055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A7J05_RS13055	COG2199	diguanylate cyclase activity
A7J05_RS13060	COG5662	AntiSigma factor
A7J05_RS13065	COG1595	DNA-templated transcription, initiation
A7J05_RS13075	COG2135	peptidase activity
A7J05_RS13085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7J05_RS13095	COG2076	Multidrug Resistance protein
A7J05_RS13105	COG0483	inositol monophosphate 1-phosphatase activity
A7J05_RS13115	COG0753	catalase activity
A7J05_RS13145	COG1615	UPF0182 protein
A7J05_RS13155	COG3480	Lon protease (S16) C-terminal proteolytic domain
A7J05_RS13205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A7J05_RS13245	COG1136	(ABC) transporter
A7J05_RS13265	COG2816	NAD+ diphosphatase activity
A7J05_RS13270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J05_RS13275	COG0210	DNA helicase
A7J05_RS13300	COG0596	Alpha beta hydrolase
A7J05_RS13370	COG0513	Belongs to the DEAD box helicase family
A7J05_RS13380	COG1432	Conserved Protein
A7J05_RS13385	COG2095	MarC family integral membrane protein
A7J05_RS13400	COG2814	Major facilitator Superfamily
A7J05_RS13410	COG0598	Magnesium transport protein CorA
A7J05_RS13445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7J05_RS13450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7J05_RS13460	COG1595	DNA-templated transcription, initiation
A7J05_RS13475	COG1024	Enoyl-CoA hydratase
A7J05_RS13480	COG2818	Glycosylase
A7J05_RS13490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7J05_RS13500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J05_RS13540	COG2197	response regulator
A7J05_RS13545	COG4585	Histidine kinase
A7J05_RS13555	COG1131	(ABC) transporter
A7J05_RS13570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7J05_RS13595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS13600	COG0601	transmembrane transport
A7J05_RS13605	COG4166	transmembrane transport
A7J05_RS13610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS13615	COG4166	transmembrane transport
A7J05_RS13620	COG0601	transmembrane transport
A7J05_RS13625	COG0444	Belongs to the ABC transporter superfamily
A7J05_RS13630	COG4608	Belongs to the ABC transporter superfamily
A7J05_RS13635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7J05_RS13640	COG4608	Belongs to the ABC transporter superfamily
A7J05_RS13645	COG0444	Belongs to the ABC transporter superfamily
A7J05_RS13650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS13655	COG0601	transmembrane transport
A7J05_RS13665	COG1217	gtp-binding protein TYPA
A7J05_RS13790	COG0477	Major facilitator Superfamily
A7J05_RS13820	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS13830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7J05_RS13855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS13860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS13865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J05_RS13870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7J05_RS13875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7J05_RS13880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A7J05_RS13885	COG2814	Major facilitator Superfamily
A7J05_RS13905	COG3629	intracellular signal transduction
A7J05_RS13915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J05_RS13925	COG2197	response regulator
A7J05_RS13935	COG1131	(ABC) transporter
A7J05_RS13955	COG0012	GTP binding
A7J05_RS13970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7J05_RS13975	COG1113	amino acid transport
A7J05_RS13980	COG1570	exodeoxyribonuclease VII activity
A7J05_RS13985	COG1722	exodeoxyribonuclease VII activity
A7J05_RS13990	COG0778	Nitroreductase
A7J05_RS14020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A7J05_RS14020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A7J05_RS14025	COG0114	fumarate hydratase activity
A7J05_RS14045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J05_RS14055	COG1136	(ABC) transporter
A7J05_RS14070	COG0450	alkyl hydroperoxide reductase
A7J05_RS14075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS14090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A7J05_RS14095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7J05_RS14100	COG0667	Aldo Keto reductase
A7J05_RS14110	COG2885	chlorophyll binding
A7J05_RS14175	COG2610	gluconate transmembrane transporter activity
A7J05_RS14180	COG0251	oxidation-reduction process
A7J05_RS14185	COG1414	Transcriptional regulator
A7J05_RS14200	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A7J05_RS14205	COG0513	Belongs to the DEAD box helicase family
A7J05_RS14210	COG1278	Cold shock
A7J05_RS14225	COG0071	Belongs to the small heat shock protein (HSP20) family
A7J05_RS14250	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A7J05_RS14260	COG0477	Major facilitator Superfamily
A7J05_RS14265	COG1309	transcriptional regulator
A7J05_RS14275	COG1331	Highly conserved protein containing a thioredoxin domain
A7J05_RS14295	COG0488	(ABC) transporter
A7J05_RS14325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7J05_RS14335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7J05_RS14350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7J05_RS14355	COG2255	four-way junction helicase activity
A7J05_RS14360	COG1595	DNA-templated transcription, initiation
A7J05_RS14380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J05_RS14390	COG0740	serine-type endopeptidase activity
A7J05_RS14395	COG0740	serine-type endopeptidase activity
A7J05_RS14410	COG1064	alcohol dehydrogenase
A7J05_RS14420	COG1733	regulation of RNA biosynthetic process
A7J05_RS14430	COG1376	ErfK ybiS ycfS ynhG family protein
A7J05_RS14445	COG2986	histidine ammonia-lyase
A7J05_RS14455	COG1024	Enoyl-CoA hydratase
A7J05_RS14460	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A7J05_RS14470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J05_RS14480	COG0424	maF-like protein
A7J05_RS14490	COG4770	biotin carboxylase activity
A7J05_RS14520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7J05_RS14540	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS14545	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS14560	COG1595	DNA-templated transcription, initiation
A7J05_RS14565	COG0745	RESPONSE REGULATOR receiver
A7J05_RS14570	COG2205	protein histidine kinase activity
A7J05_RS14595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7J05_RS14605	COG0583	DNA-binding transcription factor activity
A7J05_RS14610	COG2814	Major facilitator Superfamily
A7J05_RS14640	COG1079	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS14645	COG4603	Belongs to the binding-protein-dependent transport system permease family
A7J05_RS14650	COG3845	ABC transporter
A7J05_RS14655	COG1744	ABC transporter substrate-binding protein PnrA-like
A7J05_RS14660	COG1744	ABC transporter substrate-binding protein PnrA-like
A7J05_RS14665	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A7J05_RS14665	COG1473	amidohydrolase
A7J05_RS14685	COG2089	acid synthase
A7J05_RS14700	COG1216	Glycosyl transferase, family 2
A7J05_RS14710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A7J05_RS14745	COG1595	DNA-templated transcription, initiation
A7J05_RS14755	COG1595	DNA-templated transcription, initiation
A7J05_RS14780	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A7J05_RS14790	COG2009	succinate dehydrogenase
A7J05_RS14800	COG1053	succinate dehydrogenase
A7J05_RS14825	COG1408	metallophosphoesterase
A7J05_RS14835	COG1686	Belongs to the peptidase S11 family
A7J05_RS14840	COG1295	ribonuclease BN
A7J05_RS14855	COG0671	phosphoesterase, PA-phosphatase related
A7J05_RS14875	COG0180	Tryptophanyl-tRNA synthetase
A7J05_RS14880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7J05_RS14885	COG0754	glutathionylspermidine amidase activity
A7J05_RS14895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J05_RS14900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS14905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS14910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A7J05_RS14920	COG4176	ABC-type proline glycine betaine transport system permease component
A7J05_RS14925	COG0517	IMP dehydrogenase activity
A7J05_RS14925	COG4175	Glycine betaine
A7J05_RS14935	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS14945	COG1476	TRANSCRIPTIONal
A7J05_RS14965	COG0039	L-malate dehydrogenase activity
A7J05_RS14980	COG2197	response regulator
A7J05_RS14985	COG4585	Histidine kinase
A7J05_RS14995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7J05_RS15005	COG0138	bifunctional purine biosynthesis protein purh
A7J05_RS15035	COG0045	succinate-CoA ligase (ADP-forming) activity
A7J05_RS15040	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A7J05_RS15045	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A7J05_RS15050	COG0714	Associated with various cellular activities
A7J05_RS15065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7J05_RS15065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7J05_RS15095	COG0791	NLP P60 protein
A7J05_RS15100	COG2197	response regulator
A7J05_RS15135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7J05_RS15135	COG0519	Catalyzes the synthesis of GMP from XMP
A7J05_RS15170	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS15175	COG0515	serine threonine protein kinase
A7J05_RS15180	COG0515	serine threonine protein kinase
A7J05_RS15185	COG0515	serine threonine protein kinase
A7J05_RS15200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7J05_RS15210	COG0516	GMP reductase activity
A7J05_RS15220	COG1595	DNA-templated transcription, initiation
A7J05_RS15235	COG0583	DNA-binding transcription factor activity
A7J05_RS15245	COG4221	oxidoreductase activity
A7J05_RS15250	COG0459	protein refolding
A7J05_RS15265	COG0726	polysaccharide deacetylase
A7J05_RS15275	COG4941	Belongs to the sigma-70 factor family
A7J05_RS15295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7J05_RS15320	COG0802	atpase or kinase
A7J05_RS15330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7J05_RS15340	COG0736	holo-[acyl-carrier-protein] synthase activity
A7J05_RS15345	COG1072	(Pantothenic acid kinase))
A7J05_RS15355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7J05_RS15360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7J05_RS15365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7J05_RS15380	COG0101	tRNA pseudouridine synthase activity
A7J05_RS15385	COG0203	ribosomal protein L17
A7J05_RS15390	COG0202	RNA polymerase activity
A7J05_RS15395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7J05_RS15400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7J05_RS15405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7J05_RS15410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7J05_RS15420	COG0563	adenylate kinase activity
A7J05_RS15430	COG0200	Binds to the 23S rRNA
A7J05_RS15435	COG1841	ribosomal large subunit assembly
A7J05_RS15440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7J05_RS15445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7J05_RS15450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7J05_RS15455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7J05_RS15465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7J05_RS15470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7J05_RS15475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7J05_RS15480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7J05_RS15485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7J05_RS15490	COG0255	Belongs to the universal ribosomal protein uL29 family
A7J05_RS15495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7J05_RS15500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7J05_RS15505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7J05_RS15510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7J05_RS15515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7J05_RS15520	COG0089	rRNA binding
A7J05_RS15525	COG0088	Forms part of the polypeptide exit tunnel
A7J05_RS15530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7J05_RS15535	COG0051	transcription antitermination factor activity, RNA binding
A7J05_RS15565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7J05_RS15570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7J05_RS15575	COG0049	tRNA binding
A7J05_RS15580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7J05_RS15595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7J05_RS15600	COG0085	RNA polymerase activity
A7J05_RS15610	COG0222	ribosome binding
A7J05_RS15615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7J05_RS15630	COG0081	regulation of translation
A7J05_RS15635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7J05_RS15645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7J05_RS15655	COG0436	Aminotransferase
A7J05_RS15660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7J05_RS15675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7J05_RS15685	COG2030	dehydratase
A7J05_RS15690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7J05_RS15705	COG0402	S-adenosylhomocysteine deaminase activity
A7J05_RS15710	COG0702	epimerase
A7J05_RS15725	COG1666	GTP binding
A7J05_RS15735	COG2261	transglycosylase associated protein
A7J05_RS15740	COG3304	Inner membrane component domain
A7J05_RS15745	COG0501	Belongs to the peptidase M48B family
A7J05_RS15750	COG1007	ATP synthesis coupled electron transport
A7J05_RS15760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7J05_RS15765	COG0713	ATP synthesis coupled electron transport
A7J05_RS15770	COG0839	Belongs to the complex I subunit 6 family
A7J05_RS15775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J05_RS15780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7J05_RS15785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J05_RS15790	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J05_RS15795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J05_RS15815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7J05_RS15815	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7J05_RS15820	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7J05_RS15825	COG1733	regulation of RNA biosynthetic process
A7J05_RS15830	COG0702	epimerase
A7J05_RS15850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J05_RS15870	COG0142	geranyltranstransferase activity
A7J05_RS15875	COG3104	oligopeptide transport
A7J05_RS15880	COG2936	dipeptidyl-peptidase activity
A7J05_RS15885	COG0561	phosphatase activity
A7J05_RS15895	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7J05_RS15905	COG1007	ATP synthesis coupled electron transport
A7J05_RS15915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7J05_RS15920	COG0713	ATP synthesis coupled electron transport
A7J05_RS15925	COG0839	Belongs to the complex I subunit 6 family
A7J05_RS15930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J05_RS15935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7J05_RS15940	COG1034	ATP synthesis coupled electron transport
A7J05_RS15945	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A7J05_RS15955	COG0649	NAD binding
A7J05_RS15960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J05_RS15965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J05_RS15975	COG3103	Sh3 type 3 domain protein
A7J05_RS15975	COG1388	LysM domain
A7J05_RS15975	COG0791	NLP P60 protein
A7J05_RS16000	COG2226	methyltransferase
A7J05_RS16010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7J05_RS16055	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A7J05_RS16070	COG2318	DinB family
A7J05_RS16125	COG1674	ftsk spoiiie
A7J05_RS16140	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A7J05_RS16145	COG1278	Cold shock
A7J05_RS16150	COG4608	Belongs to the ABC transporter superfamily
A7J05_RS16160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS16170	COG0747	negative chemotaxis
A7J05_RS16240	COG1309	transcriptional regulator
A7J05_RS16245	COG1301	dicarboxylic acid transport
A7J05_RS16260	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7J05_RS16270	COG0163	prenyltransferase activity
A7J05_RS16280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7J05_RS16295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7J05_RS16300	COG1333	cytochrome c biogenesis protein
A7J05_RS16305	COG0785	Cytochrome C biogenesis protein
A7J05_RS16320	COG0406	alpha-ribazole phosphatase activity
A7J05_RS16325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7J05_RS16340	COG0431	NADPH-dependent FMN reductase
A7J05_RS16345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS16360	COG1742	UPF0060 membrane protein
A7J05_RS16375	COG1690	Belongs to the RtcB family
A7J05_RS16395	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A7J05_RS16400	COG0018	arginyl-trna synthetase
A7J05_RS16405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J05_RS16435	COG3321	synthase
A7J05_RS16435	COG0604	alcohol dehydrogenase
A7J05_RS16440	COG0113	porphobilinogen synthase activity
A7J05_RS16445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7J05_RS16445	COG1648	precorrin-2 dehydrogenase activity
A7J05_RS16450	COG0181	hydroxymethylbilane synthase activity
A7J05_RS16455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A7J05_RS16460	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A7J05_RS16510	COG0123	including yeast histone deacetylase and acetoin utilization protein
A7J05_RS16520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J05_RS16545	COG0180	Tryptophanyl-tRNA synthetase
A7J05_RS16550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7J05_RS16570	COG0129	dihydroxy-acid dehydratase activity
A7J05_RS16575	COG1082	Xylose isomerase domain protein TIM barrel
A7J05_RS16580	COG0248	Ppx GppA phosphatase
A7J05_RS16600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A7J05_RS16610	COG0671	phosphoesterase, PA-phosphatase related
A7J05_RS16625	COG1194	a g-specific adenine glycosylase
A7J05_RS16630	COG1595	DNA-templated transcription, initiation
A7J05_RS16640	COG0745	RESPONSE REGULATOR receiver
A7J05_RS16645	COG2205	protein histidine kinase activity
A7J05_RS16650	COG0477	Major facilitator Superfamily
A7J05_RS16660	COG0739	heme binding
A7J05_RS16685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7J05_RS16700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A7J05_RS16710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A7J05_RS16715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7J05_RS16740	COG2197	response regulator
A7J05_RS16755	COG0649	NAD binding
A7J05_RS16780	COG1174	glycine betaine transport
A7J05_RS16785	COG1174	glycine betaine transport
A7J05_RS16815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7J05_RS16820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7J05_RS16830	COG0302	gtp cyclohydrolase
A7J05_RS16845	COG0037	tRNA processing
A7J05_RS16855	COG2027	D-alanyl-D-alanine carboxypeptidase
A7J05_RS16860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A7J05_RS16875	COG0789	Transcriptional regulator
A7J05_RS16885	COG2318	DinB family
A7J05_RS16895	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS16915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7J05_RS16925	COG0254	rRNA binding
A7J05_RS16930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7J05_RS16935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7J05_RS16940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7J05_RS16950	COG1289	transmembrane transporter activity
A7J05_RS16960	COG1136	(ABC) transporter
A7J05_RS16970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7J05_RS16970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7J05_RS16975	COG5002	protein histidine kinase activity
A7J05_RS16980	COG0745	RESPONSE REGULATOR receiver
A7J05_RS17005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J05_RS17010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS17030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS17040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7J05_RS17045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS17050	COG3629	intracellular signal transduction
A7J05_RS17100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS17115	COG2197	response regulator
A7J05_RS17145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7J05_RS17150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7J05_RS17155	COG1754	DNA topoisomerase type I activity
A7J05_RS17155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7J05_RS17165	COG2890	protein-(glutamine-N5) methyltransferase activity
A7J05_RS17175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A7J05_RS17185	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J05_RS17190	COG1205	dead DEAH box helicase
A7J05_RS17190	COG1111	helicase
A7J05_RS17250	COG0288	reversible hydration of carbon dioxide
A7J05_RS17255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7J05_RS17260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7J05_RS17270	COG2267	carboxylic ester hydrolase activity
A7J05_RS17300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7J05_RS17320	COG0003	Pfam Anion-transporting ATPase
A7J05_RS17335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A7J05_RS17345	COG1408	metallophosphoesterase
A7J05_RS17365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7J05_RS17415	COG2319	Wd-40 repeat
A7J05_RS17415	COG4249	Peptidase C14 caspase catalytic subunit p20
A7J05_RS17475	COG2304	oxidoreductase activity
A7J05_RS17505	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS17510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7J05_RS17520	COG0728	peptidoglycan biosynthetic process
A7J05_RS17530	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS17555	COG2072	flavoprotein involved in K transport
A7J05_RS17600	COG1595	DNA-templated transcription, initiation
A7J05_RS17620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7J05_RS17625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7J05_RS17640	COG0463	Glycosyl transferase, family 2
A7J05_RS17650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS17665	COG0745	RESPONSE REGULATOR receiver
A7J05_RS17685	COG0693	protein deglycase activity
A7J05_RS17695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7J05_RS17695	COG0515	serine threonine protein kinase
A7J05_RS17700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7J05_RS17705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7J05_RS17720	COG1131	(ABC) transporter
A7J05_RS17725	COG3559	Exporter of polyketide antibiotics
A7J05_RS17730	COG2124	cytochrome p450
A7J05_RS17735	COG2197	response regulator
A7J05_RS17740	COG4585	Histidine kinase
A7J05_RS17755	COG3844	kynureninase activity
A7J05_RS17780	COG0191	fructose-bisphosphate aldolase activity
A7J05_RS17785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7J05_RS17820	COG0542	response to heat
A7J05_RS17850	COG0789	Transcriptional regulator
A7J05_RS17855	COG0484	heat shock protein binding
A7J05_RS17860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7J05_RS17865	COG0443	Heat shock 70 kDa protein
A7J05_RS17870	COG0247	lactate metabolic process
A7J05_RS17870	COG2181	nitrate reductase activity
A7J05_RS17915	COG0717	Belongs to the dCTP deaminase family
A7J05_RS17955	COG2197	response regulator
A7J05_RS17975	COG1309	transcriptional regulator
A7J05_RS18010	COG0583	DNA-binding transcription factor activity
A7J05_RS18040	COG1289	transmembrane transporter activity
A7J05_RS18050	COG0583	DNA-binding transcription factor activity
A7J05_RS18065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7J05_RS18070	COG1309	transcriptional regulator
A7J05_RS18085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7J05_RS18100	COG1741	Belongs to the pirin family
A7J05_RS18110	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS18120	COG1362	aminopeptidase activity
A7J05_RS18140	COG2271	Major facilitator Superfamily
A7J05_RS18155	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7J05_RS18160	COG0022	dehydrogenase e1 component
A7J05_RS18180	COG0515	serine threonine protein kinase
A7J05_RS18185	COG0515	serine threonine protein kinase
A7J05_RS18200	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS18200	COG3321	synthase
A7J05_RS18200	COG0604	alcohol dehydrogenase
A7J05_RS18205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7J05_RS18210	COG0303	'Molybdopterin
A7J05_RS18220	COG0746	molybdenum cofactor guanylyltransferase activity
A7J05_RS18240	COG1522	sequence-specific DNA binding
A7J05_RS18245	COG1309	transcriptional regulator
A7J05_RS18250	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J05_RS18260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7J05_RS18275	COG3396	Phenylacetate-CoA oxygenase
A7J05_RS18280	COG3460	Phenylacetate-CoA oxygenase
A7J05_RS18285	COG3396	Phenylacetate-CoA oxygenase
A7J05_RS18290	COG2151	metal-sulfur cluster biosynthetic enzyme
A7J05_RS18295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7J05_RS18300	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS18305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7J05_RS18325	COG1716	ATPase activity
A7J05_RS18330	COG1716	ATPase activity
A7J05_RS18355	COG0515	serine threonine protein kinase
A7J05_RS18360	COG3764	Sortase (surface protein transpeptidase)
A7J05_RS18365	COG3764	Sortase (surface protein transpeptidase)
A7J05_RS18375	COG3764	Sortase (surface protein transpeptidase)
A7J05_RS18390	COG0705	Rhomboid family
A7J05_RS18415	COG0515	serine threonine protein kinase
A7J05_RS18445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7J05_RS18455	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A7J05_RS18460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7J05_RS18465	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A7J05_RS18470	COG0592	DNA-directed DNA polymerase activity
A7J05_RS18480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7J05_RS18485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A7J05_RS18490	COG0594	ribonuclease P activity
A7J05_RS18495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A7J05_RS18500	COG0706	membrane insertase activity
A7J05_RS18510	COG0357	Ribosomal RNA small subunit methyltransferase G
A7J05_RS18515	COG1192	Involved in chromosome partitioning
A7J05_RS18530	COG3118	belongs to the thioredoxin family
A7J05_RS18535	COG0492	ferredoxin-NADP+ reductase activity
A7J05_RS18545	COG1595	DNA-templated transcription, initiation
A7J05_RS18565	COG0617	tRNA 3'-terminal CCA addition
A7J05_RS18580	COG1260	myo-inositol-1-phosphate synthase
A7J05_RS18590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J05_RS18615	COG0360	Binds together with S18 to 16S ribosomal RNA
A7J05_RS18620	COG0629	single-stranded DNA binding
A7J05_RS18625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7J05_RS18630	COG0359	binds to the 23S rRNA
A7J05_RS18640	COG0305	Participates in initiation and elongation during chromosome replication
A7J05_RS18660	COG2814	Major facilitator Superfamily
A7J05_RS18695	COG0626	cystathionine gamma-synthase activity
A7J05_RS18700	COG1950	PFAM Membrane protein of
A7J05_RS18705	COG0662	Cupin 2, conserved barrel domain protein
A7J05_RS18730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A7J05_RS18745	COG1609	Transcriptional regulator
A7J05_RS18750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7J05_RS18755	COG1271	oxidase subunit
A7J05_RS18760	COG1294	oxidase, subunit
A7J05_RS18765	COG4988	ABC transporter
A7J05_RS18775	COG0561	phosphatase activity
A7J05_RS18790	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A7J05_RS18795	COG0789	Transcriptional regulator
A7J05_RS18830	COG0561	phosphatase activity
A7J05_RS18835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7J05_RS18860	COG1999	signal sequence binding
A7J05_RS18880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J05_RS18885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS18890	COG0006	proline dipeptidase activity
A7J05_RS18910	COG0653	protein targeting
A7J05_RS18925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7J05_RS18950	COG0494	nUDIX hydrolase
A7J05_RS18995	COG1595	DNA-templated transcription, initiation
A7J05_RS19000	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS19005	COG0784	Response regulator, receiver
A7J05_RS19030	COG0745	RESPONSE REGULATOR receiver
A7J05_RS19035	COG2205	protein histidine kinase activity
A7J05_RS19045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7J05_RS19050	COG0477	Major facilitator Superfamily
A7J05_RS19065	COG0477	Major facilitator Superfamily
A7J05_RS19080	COG1191	sigma factor activity
A7J05_RS19085	COG1191	sigma factor activity
A7J05_RS19120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A7J05_RS19150	COG0697	spore germination
A7J05_RS19210	COG2197	response regulator
A7J05_RS19245	COG0151	Belongs to the GarS family
A7J05_RS19260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7J05_RS19270	COG2197	response regulator
A7J05_RS19305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7J05_RS19310	COG0047	phosphoribosylformylglycinamidine synthase activity
A7J05_RS19315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7J05_RS19345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7J05_RS19380	COG1643	Atp-dependent helicase
A7J05_RS19390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7J05_RS19390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7J05_RS19395	COG0785	Cytochrome C biogenesis protein
A7J05_RS19435	COG0513	Belongs to the DEAD box helicase family
A7J05_RS19485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7J05_RS19490	COG0579	oxidoreductase
A7J05_RS19520	COG1252	NADH dehydrogenase
A7J05_RS19560	COG2197	response regulator
A7J05_RS19565	COG4585	Histidine kinase
A7J05_RS19575	COG1131	(ABC) transporter
A7J05_RS19625	COG0739	heme binding
A7J05_RS19625	COG0741	lytic transglycosylase activity
A7J05_RS19625	COG1196	nuclear chromosome segregation
A7J05_RS19630	COG0671	phosphoesterase, PA-phosphatase related
A7J05_RS19635	COG0277	FAD linked oxidase domain protein
A7J05_RS19645	COG1937	Protein conserved in bacteria
A7J05_RS19655	COG0306	phosphate transporter
A7J05_RS19660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7J05_RS19690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7J05_RS19700	COG1116	anion transmembrane transporter activity
A7J05_RS19705	COG1725	Transcriptional regulator
A7J05_RS19710	COG0456	acetyltransferase
A7J05_RS19715	COG0737	Belongs to the 5'-nucleotidase family
A7J05_RS19725	COG0488	(ABC) transporter
A7J05_RS19735	COG0745	RESPONSE REGULATOR receiver
A7J05_RS19740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7J05_RS19745	COG1609	Transcriptional regulator
A7J05_RS19750	COG0745	RESPONSE REGULATOR receiver
A7J05_RS19780	COG2897	thiosulfate sulfurtransferase activity
A7J05_RS19800	COG3485	protocatechuate 3,4-dioxygenase
A7J05_RS19805	COG0735	belongs to the Fur family
A7J05_RS19815	COG1490	D-aminoacyl-tRNA deacylase activity
A7J05_RS19825	COG4552	Acetyltransferase involved in intracellular survival and related
A7J05_RS19835	COG2186	Transcriptional regulator
A7J05_RS19845	COG2188	Transcriptional regulator
A7J05_RS19930	COG0768	penicillin binding
A7J05_RS19950	COG1309	transcriptional regulator
A7J05_RS19995	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS20015	COG0588	phosphoglycerate mutase activity
A7J05_RS20040	COG5002	protein histidine kinase activity
A7J05_RS20060	COG1329	Transcriptional regulator
A7J05_RS20065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7J05_RS20070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A7J05_RS20075	COG3467	pyridoxamine 5'-phosphate
A7J05_RS20080	COG0215	cysteine-tRNA ligase activity
A7J05_RS20085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7J05_RS20095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7J05_RS20105	COG3842	ATPase activity
A7J05_RS20115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS20155	COG2197	response regulator
A7J05_RS20190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7J05_RS20215	COG1105	Belongs to the carbohydrate kinase PfkB family
A7J05_RS20230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7J05_RS20255	COG0463	Glycosyl transferase, family 2
A7J05_RS20310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A7J05_RS20315	COG1737	Transcriptional regulator
A7J05_RS20370	COG3973	AAA domain
A7J05_RS20380	COG1061	Type III restriction enzyme res subunit
A7J05_RS20405	COG1278	Cold shock
A7J05_RS20410	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A7J05_RS20415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7J05_RS20425	COG2814	Major facilitator Superfamily
A7J05_RS20450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7J05_RS20460	COG2252	PERMEase
A7J05_RS20490	COG0667	Aldo Keto reductase
A7J05_RS20550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A7J05_RS20580	COG2205	protein histidine kinase activity
A7J05_RS20585	COG0277	FAD linked oxidase domain protein
A7J05_RS20605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J05_RS20620	COG1024	Enoyl-CoA hydratase
A7J05_RS20635	COG0259	pyridoxamine-phosphate oxidase activity
A7J05_RS20640	COG2945	thiolester hydrolase activity
A7J05_RS20640	COG0596	Alpha beta hydrolase
A7J05_RS20650	COG4821	SIS domain
A7J05_RS20710	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J05_RS20725	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS20730	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS20735	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS20750	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS20755	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS20770	COG2814	Major facilitator Superfamily
A7J05_RS20775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7J05_RS20780	COG1024	Enoyl-CoA hydratase
A7J05_RS20790	COG2072	flavoprotein involved in K transport
A7J05_RS20810	COG0259	pyridoxamine-phosphate oxidase activity
A7J05_RS20820	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS20830	COG1309	transcriptional regulator
A7J05_RS20845	COG1024	Enoyl-CoA hydratase
A7J05_RS20880	COG3629	intracellular signal transduction
A7J05_RS20880	COG3903	Transcriptional regulator
A7J05_RS20895	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS20910	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS20925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7J05_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS20970	COG1686	Belongs to the peptidase S11 family
A7J05_RS20980	COG1653	transport
A7J05_RS21010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J05_RS21015	COG5640	endopeptidase activity
A7J05_RS21035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7J05_RS21070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7J05_RS21165	COG0582	viral genome integration into host DNA
A7J05_RS21175	COG1764	response to oxidative stress
A7J05_RS21180	COG1846	Transcriptional regulator
A7J05_RS21185	COG3433	isochorismatase activity
A7J05_RS21185	COG1535	isochorismatase
A7J05_RS21190	COG1021	2,3-dihydroxybenzoate-AMP ligase
A7J05_RS21195	COG1169	isochorismate synthase
A7J05_RS21200	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS21210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7J05_RS21230	COG1846	Transcriptional regulator
A7J05_RS21235	COG3384	dioxygenase
A7J05_RS21245	COG1247	-acetyltransferase
A7J05_RS21260	COG0477	Major facilitator Superfamily
A7J05_RS21265	COG1349	DNA-binding transcription factor activity
A7J05_RS21275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7J05_RS21275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7J05_RS21275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7J05_RS21310	COG1970	mechanosensitive ion channel activity
A7J05_RS21320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A7J05_RS21340	COG2366	antibiotic biosynthetic process
A7J05_RS21345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7J05_RS21350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7J05_RS21360	COG0315	cyclic pyranopterin monophosphate synthase activity
A7J05_RS21365	COG0315	cyclic pyranopterin monophosphate synthase activity
A7J05_RS21365	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7J05_RS21370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7J05_RS21495	COG2072	flavoprotein involved in K transport
A7J05_RS21505	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS21515	COG0793	Belongs to the peptidase S41A family
A7J05_RS21515	COG4946	Tricorn protease homolog
A7J05_RS21525	COG2409	Drug exporters of the RND superfamily
A7J05_RS21535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7J05_RS21550	COG1695	Transcriptional regulator
A7J05_RS21565	COG0442	prolyl-tRNA aminoacylation
A7J05_RS21570	COG0768	penicillin binding
A7J05_RS21575	COG0768	penicillin binding
A7J05_RS21595	COG0084	hydrolase, TatD family'
A7J05_RS21600	COG3584	3D domain protein
A7J05_RS21600	COG3583	domain protein
A7J05_RS21605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7J05_RS21610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7J05_RS21620	COG0488	(ABC) transporter
A7J05_RS21660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A7J05_RS21675	COG2197	response regulator
A7J05_RS21680	COG1846	Transcriptional regulator
A7J05_RS21685	COG4106	trans-aconitate 2-methyltransferase activity
A7J05_RS21705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7J05_RS21710	COG0193	aminoacyl-tRNA hydrolase activity
A7J05_RS21715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7J05_RS21720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7J05_RS21725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7J05_RS21740	COG4585	Histidine kinase
A7J05_RS21770	COG0477	Major facilitator Superfamily
A7J05_RS21775	COG1136	(ABC) transporter
A7J05_RS21780	COG0577	efflux transmembrane transporter activity
A7J05_RS21845	COG2124	cytochrome p450
A7J05_RS21860	COG0148	phosphopyruvate hydratase activity
A7J05_RS21890	COG1252	NADH dehydrogenase
A7J05_RS21895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7J05_RS21900	COG0577	efflux transmembrane transporter activity
A7J05_RS21905	COG1136	(ABC) transporter
A7J05_RS21935	COG0183	Belongs to the thiolase family
A7J05_RS21940	COG0515	serine threonine protein kinase
A7J05_RS21945	COG2755	lipolytic protein G-D-S-L family
A7J05_RS21955	COG0778	Nitroreductase
A7J05_RS21970	COG0500	methyltransferase
A7J05_RS21980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS21985	COG0156	8-amino-7-oxononanoate synthase activity
A7J05_RS21990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS22000	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS22010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J05_RS22015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS22020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS22035	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS22040	COG3629	intracellular signal transduction
A7J05_RS22055	COG2409	Drug exporters of the RND superfamily
A7J05_RS22065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7J05_RS22075	COG1174	glycine betaine transport
A7J05_RS22080	COG1174	glycine betaine transport
A7J05_RS22090	COG2986	histidine ammonia-lyase
A7J05_RS22125	COG0019	diaminopimelate decarboxylase activity
A7J05_RS22130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A7J05_RS22135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J05_RS22145	COG1228	amidohydrolase
A7J05_RS22165	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A7J05_RS22165	COG1672	PFAM Archaeal ATPase
A7J05_RS22170	COG1191	sigma factor activity
A7J05_RS22175	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J05_RS22200	COG3104	oligopeptide transport
A7J05_RS22205	COG0745	RESPONSE REGULATOR receiver
A7J05_RS22210	COG2205	protein histidine kinase activity
A7J05_RS22275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A7J05_RS22295	COG1316	TRANSCRIPTIONal
A7J05_RS22305	COG1316	TRANSCRIPTIONal
A7J05_RS22320	COG1316	TRANSCRIPTIONal
A7J05_RS22350	COG0778	Nitroreductase
A7J05_RS22350	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A7J05_RS22355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A7J05_RS22395	COG1620	l-lactate permease
A7J05_RS22400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7J05_RS22405	COG2835	tetraacyldisaccharide 4'-kinase activity
A7J05_RS22415	COG1482	cell wall glycoprotein biosynthetic process
A7J05_RS22425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A7J05_RS22470	COG0714	Associated with various cellular activities
A7J05_RS22490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A7J05_RS22495	COG0745	RESPONSE REGULATOR receiver
A7J05_RS22500	COG5000	phosphorelay sensor kinase activity
A7J05_RS22500	COG5002	protein histidine kinase activity
A7J05_RS22505	COG0823	Involved in the tonB-independent uptake of proteins
A7J05_RS22515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7J05_RS22520	COG2197	response regulator
A7J05_RS22525	COG3214	Protein conserved in bacteria
A7J05_RS22535	COG0653	protein targeting
A7J05_RS22560	COG2902	Dehydrogenase
A7J05_RS22565	COG0463	Glycosyl transferase, family 2
A7J05_RS22575	COG1216	Glycosyl transferase, family 2
A7J05_RS22580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7J05_RS22585	COG1134	teichoic acid transport
A7J05_RS22595	COG1309	transcriptional regulator
A7J05_RS22605	COG2197	response regulator
A7J05_RS22615	COG0577	efflux transmembrane transporter activity
A7J05_RS22615	COG1136	(ABC) transporter
A7J05_RS22635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7J05_RS22640	COG1216	Glycosyl transferase, family 2
A7J05_RS22640	COG1442	glycosyl transferase family 8
A7J05_RS22645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7J05_RS22650	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS22660	COG0395	ABC-type sugar transport system, permease component
A7J05_RS22665	COG1175	transmembrane transport
A7J05_RS22680	COG0515	serine threonine protein kinase
A7J05_RS22685	COG0515	serine threonine protein kinase
A7J05_RS22690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A7J05_RS22705	COG2884	Cell division ATP-binding protein ftsE
A7J05_RS22710	COG2177	Part of the ABC transporter FtsEX involved in
A7J05_RS22715	COG0793	Belongs to the peptidase S41A family
A7J05_RS22720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7J05_RS22730	COG2027	D-alanyl-D-alanine carboxypeptidase
A7J05_RS22740	COG0583	DNA-binding transcription factor activity
A7J05_RS22775	COG0697	spore germination
A7J05_RS22780	COG1846	Transcriptional regulator
A7J05_RS22785	COG2223	nitrite transmembrane transporter activity
A7J05_RS22810	COG3973	AAA domain
A7J05_RS22820	COG0776	regulation of translation
A7J05_RS22825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7J05_RS22830	COG1678	Uncharacterized ACR, COG1678
A7J05_RS22840	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A7J05_RS22875	COG2318	DinB family
A7J05_RS22910	COG3480	Lon protease (S16) C-terminal proteolytic domain
A7J05_RS22930	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A7J05_RS22950	COG0277	FAD linked oxidase domain protein
A7J05_RS22985	COG1335	isochorismatase
A7J05_RS22995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7J05_RS23005	COG1113	amino acid transport
A7J05_RS23030	COG1234	tRNA 3'-trailer cleavage
A7J05_RS23035	COG1263	PTS System
A7J05_RS23040	COG1263	PTS System
A7J05_RS23045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J05_RS23050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A7J05_RS23060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7J05_RS23080	COG0477	Major facilitator Superfamily
A7J05_RS23140	COG2814	Major facilitator Superfamily
A7J05_RS23140	COG0477	Major facilitator Superfamily
A7J05_RS23145	COG2271	Major facilitator Superfamily
A7J05_RS23160	COG0590	tRNA wobble adenosine to inosine editing
A7J05_RS23195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J05_RS23205	COG0706	membrane insertase activity
A7J05_RS23215	COG4702	Belongs to the UPF0303 family
A7J05_RS23220	COG0673	inositol 2-dehydrogenase activity
A7J05_RS23235	COG2188	Transcriptional regulator
A7J05_RS23240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS23300	COG2186	Transcriptional regulator
A7J05_RS23315	COG3397	chitin binding
A7J05_RS23335	COG2409	Drug exporters of the RND superfamily
A7J05_RS23345	COG4585	Histidine kinase
A7J05_RS23355	COG4585	Histidine kinase
A7J05_RS23360	COG0586	Pfam SNARE associated Golgi protein
A7J05_RS23375	COG1126	abc transporter atp-binding protein
A7J05_RS23380	COG0765	amino acid transport
A7J05_RS23400	COG0154	amidase activity
A7J05_RS23430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS23480	COG0406	alpha-ribazole phosphatase activity
A7J05_RS23505	COG0745	RESPONSE REGULATOR receiver
A7J05_RS23525	COG0395	ABC-type sugar transport system, permease component
A7J05_RS23585	COG1388	LysM domain
A7J05_RS23585	COG0791	NLP P60 protein
A7J05_RS23615	COG5280	Phage tail tape measure protein TP901
A7J05_RS23615	COG3953	SLT domain
A7J05_RS23675	COG4695	Portal protein
A7J05_RS23890	COG5002	protein histidine kinase activity
A7J05_RS23890	COG2176	DNA-directed DNA polymerase activity
A7J05_RS23960	COG0582	viral genome integration into host DNA
A7J05_RS23970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A7J05_RS23975	COG4977	sequence-specific DNA binding
A7J05_RS23985	COG0589	response to stress
A7J05_RS23990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7J05_RS24015	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS24030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J05_RS24035	COG1309	transcriptional regulator
A7J05_RS24040	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS24045	COG1946	Acyl-CoA thioesterase
A7J05_RS24065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J05_RS24075	COG0028	Belongs to the TPP enzyme family
A7J05_RS24120	COG1472	Belongs to the glycosyl hydrolase 3 family
A7J05_RS24140	COG0456	acetyltransferase
A7J05_RS24140	COG1846	Transcriptional regulator
A7J05_RS24145	COG1280	lysine exporter protein (LysE YggA)
A7J05_RS24155	COG1609	Transcriptional regulator
A7J05_RS24160	COG0673	inositol 2-dehydrogenase activity
A7J05_RS24175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7J05_RS24205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J05_RS24215	COG3718	enzyme involved in inositol metabolism
A7J05_RS24220	COG3962	Belongs to the TPP enzyme family
A7J05_RS24240	COG1131	(ABC) transporter
A7J05_RS24260	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7J05_RS24300	COG0629	single-stranded DNA binding
A7J05_RS24325	COG2346	COG2346, Truncated hemoglobins
A7J05_RS24330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7J05_RS24360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J05_RS24375	COG1486	melibiose metabolic process
A7J05_RS24380	COG0395	ABC-type sugar transport system, permease component
A7J05_RS24385	COG1175	transmembrane transport
A7J05_RS24395	COG1846	Transcriptional regulator
A7J05_RS24395	COG1940	carbohydrate kinase activity
A7J05_RS24405	COG0668	transmembrane transport
A7J05_RS24440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7J05_RS24470	COG0583	DNA-binding transcription factor activity
A7J05_RS24525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A7J05_RS24535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A7J05_RS24540	COG1113	amino acid transport
A7J05_RS24545	COG1113	amino acid transport
A7J05_RS24550	COG1268	BioY protein
A7J05_RS24555	COG1113	amino acid transport
A7J05_RS24570	COG4552	Acetyltransferase involved in intracellular survival and related
A7J05_RS24580	COG0475	glutathione-regulated potassium exporter activity
A7J05_RS24585	COG1136	(ABC) transporter
A7J05_RS24600	COG3594	Acyltransferase
A7J05_RS24620	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7J05_RS24625	COG0740	serine-type endopeptidase activity
A7J05_RS24630	COG0740	serine-type endopeptidase activity
A7J05_RS24635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7J05_RS24660	COG0525	valine-tRNA ligase activity
A7J05_RS24670	COG1077	Cell shape determining protein MreB Mrl
A7J05_RS24675	COG0285	dihydrofolate synthase activity
A7J05_RS24685	COG0105	UTP biosynthetic process
A7J05_RS24690	COG1077	Cell shape determining protein MreB Mrl
A7J05_RS24705	COG0768	penicillin binding
A7J05_RS24710	COG0772	Belongs to the SEDS family
A7J05_RS24750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7J05_RS24755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7J05_RS24760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7J05_RS24770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7J05_RS24780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7J05_RS24795	COG0501	Belongs to the peptidase M48B family
A7J05_RS24805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7J05_RS24815	COG0799	negative regulation of ribosome biogenesis
A7J05_RS24820	COG0588	phosphoglycerate mutase activity
A7J05_RS24835	COG0477	Major facilitator Superfamily
A7J05_RS24860	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A7J05_RS24870	COG0495	leucyl-tRNA aminoacylation
A7J05_RS24880	COG1307	EDD domain protein, DegV family
A7J05_RS24885	COG1555	photosystem II stabilization
A7J05_RS24890	COG1234	tRNA 3'-trailer cleavage
A7J05_RS24895	COG2353	YceI-like domain
A7J05_RS24910	COG0268	Binds directly to 16S ribosomal RNA
A7J05_RS24915	COG0481	GTPase activity
A7J05_RS24955	COG1420	regulation of RNA biosynthetic process
A7J05_RS24960	COG0484	heat shock protein binding
A7J05_RS24965	COG2070	2-Nitropropane dioxygenase
A7J05_RS24985	COG0793	Belongs to the peptidase S41A family
A7J05_RS24985	COG4946	Tricorn protease homolog
A7J05_RS24990	COG0537	adenosine 5'-monophosphoramidase activity
A7J05_RS24995	COG1234	tRNA 3'-trailer cleavage
A7J05_RS25000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7J05_RS25010	COG4948	Mandelate Racemase Muconate Lactonizing
A7J05_RS25015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7J05_RS25015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7J05_RS25025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7J05_RS25035	COG2315	Protein conserved in bacteria
A7J05_RS25065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7J05_RS25075	COG2723	6-phospho-beta-galactosidase activity
A7J05_RS25095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7J05_RS25105	COG2409	Drug exporters of the RND superfamily
A7J05_RS25110	COG4585	Histidine kinase
A7J05_RS25115	COG2197	response regulator
A7J05_RS25120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J05_RS25125	COG4608	Belongs to the ABC transporter superfamily
A7J05_RS25130	COG0444	Belongs to the ABC transporter superfamily
A7J05_RS25140	COG0747	negative chemotaxis
A7J05_RS25145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J05_RS25195	COG1381	Involved in DNA repair and RecF pathway recombination
A7J05_RS25200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7J05_RS25210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7J05_RS25215	COG1121	(ABC) transporter
A7J05_RS25220	COG3443	Belongs to the bacterial solute-binding protein 9 family
A7J05_RS25220	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7J05_RS25225	COG0423	glycine-tRNA ligase activity
A7J05_RS25255	COG0574	Belongs to the PEP-utilizing enzyme family
A7J05_RS25255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7J05_RS25265	COG0395	ABC-type sugar transport system, permease component
A7J05_RS25270	COG1175	transmembrane transport
A7J05_RS25280	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS25285	COG1309	transcriptional regulator
A7J05_RS25295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7J05_RS25295	COG2146	nitrite reductase [NAD(P)H] activity
A7J05_RS25300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7J05_RS25340	COG0243	molybdopterin cofactor binding
A7J05_RS25345	COG2949	membrane
A7J05_RS25355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A7J05_RS25365	COG0358	DNA primase activity
A7J05_RS25370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7J05_RS25385	COG1070	Carbohydrate kinase
A7J05_RS25410	COG1295	ribonuclease BN
A7J05_RS25415	COG3585	molybdate ion transport
A7J05_RS25440	COG1077	Cell shape determining protein MreB Mrl
A7J05_RS25450	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS25455	COG0583	DNA-binding transcription factor activity
A7J05_RS25465	COG2855	membrane
A7J05_RS25505	COG4981	capsule polysaccharide biosynthetic process
A7J05_RS25550	COG2130	NADP-dependent
A7J05_RS25555	COG1764	response to oxidative stress
A7J05_RS25585	COG3226	Transcriptional regulator
A7J05_RS25590	COG0583	DNA-binding transcription factor activity
A7J05_RS25620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J05_RS25625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS25630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS25645	COG1741	Belongs to the pirin family
A7J05_RS25655	COG0789	Transcriptional regulator
A7J05_RS25660	COG0667	Aldo Keto reductase
A7J05_RS25675	COG2197	response regulator
A7J05_RS25680	COG4585	Histidine kinase
A7J05_RS25695	COG1309	transcriptional regulator
A7J05_RS25700	COG0477	Major facilitator Superfamily
A7J05_RS25710	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7J05_RS25755	COG1358	cellular component organization or biogenesis
A7J05_RS25770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J05_RS25775	COG0800	Aldolase
A7J05_RS25830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J05_RS25845	COG0456	acetyltransferase
A7J05_RS25895	COG2124	cytochrome p450
A7J05_RS25900	COG0183	Belongs to the thiolase family
A7J05_RS25915	COG3845	ABC transporter
A7J05_RS25950	COG1309	transcriptional regulator
A7J05_RS25955	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS25980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS25990	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7J05_RS26005	COG0183	Belongs to the thiolase family
A7J05_RS26015	COG2197	response regulator
A7J05_RS26030	COG2030	dehydratase
A7J05_RS26040	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS26055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7J05_RS26070	COG0800	Aldolase
A7J05_RS26075	COG3022	response to hydroperoxide
A7J05_RS26120	COG1674	ftsk spoiiie
A7J05_RS26225	COG2226	methyltransferase
A7J05_RS26235	COG2259	Doxx family
A7J05_RS26260	COG3540	Alkaline phosphatase
A7J05_RS26270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7J05_RS26285	COG1834	amidinotransferase
A7J05_RS26340	COG1994	Peptidase M50
A7J05_RS26365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7J05_RS26370	COG0477	Major facilitator Superfamily
A7J05_RS26385	COG2814	Major facilitator Superfamily
A7J05_RS26390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J05_RS26390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7J05_RS26400	COG2267	carboxylic ester hydrolase activity
A7J05_RS26415	COG1959	2 iron, 2 sulfur cluster binding
A7J05_RS26425	COG0174	glutamine synthetase
A7J05_RS26450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A7J05_RS26460	COG1609	Transcriptional regulator
A7J05_RS26465	COG0366	Alpha amylase catalytic
A7J05_RS26515	COG2197	response regulator
A7J05_RS26520	COG4585	Histidine kinase
A7J05_RS26535	COG0745	RESPONSE REGULATOR receiver
A7J05_RS26555	COG2267	carboxylic ester hydrolase activity
A7J05_RS26575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS26580	COG1120	ATPase activity
A7J05_RS26615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7J05_RS26620	COG0321	lipoyl(octanoyl) transferase activity
A7J05_RS26665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7J05_RS26675	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7J05_RS26680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7J05_RS26685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7J05_RS26690	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A7J05_RS26705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7J05_RS26705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A7J05_RS26710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A7J05_RS26730	COG4106	trans-aconitate 2-methyltransferase activity
A7J05_RS26750	COG4585	Histidine kinase
A7J05_RS26755	COG2197	response regulator
A7J05_RS26760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7J05_RS26765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7J05_RS26785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J05_RS26795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7J05_RS26800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7J05_RS26810	COG1376	ErfK ybiS ycfS ynhG family protein
A7J05_RS26820	COG1845	cytochrome c oxidase, subunit III
A7J05_RS26825	COG2010	Cytochrome c
A7J05_RS26830	COG0723	plastoquinol--plastocyanin reductase activity
A7J05_RS26835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A7J05_RS26840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7J05_RS26845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7J05_RS26850	COG1929	Belongs to the glycerate kinase type-1 family
A7J05_RS26860	COG0745	RESPONSE REGULATOR receiver
A7J05_RS26865	COG2205	protein histidine kinase activity
A7J05_RS26895	COG0791	NLP P60 protein
A7J05_RS26935	COG0003	Pfam Anion-transporting ATPase
A7J05_RS26945	COG1940	carbohydrate kinase activity
A7J05_RS26970	COG4585	Histidine kinase
A7J05_RS26975	COG2197	response regulator
A7J05_RS26980	COG0205	6-phosphofructokinase activity
A7J05_RS26985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7J05_RS27005	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A7J05_RS27010	COG0243	molybdopterin cofactor binding
A7J05_RS27015	COG2193	ferroxidase activity
A7J05_RS27020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7J05_RS27025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A7J05_RS27030	COG0515	serine threonine protein kinase
A7J05_RS27030	COG2815	serine threonine protein kinase
A7J05_RS27035	COG2022	thiamine diphosphate biosynthetic process
A7J05_RS27045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS27045	COG2022	thiamine diphosphate biosynthetic process
A7J05_RS27060	COG0352	thiamine-phosphate diphosphorylase activity
A7J05_RS27085	COG1309	transcriptional regulator
A7J05_RS27095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7J05_RS27115	COG0714	Associated with various cellular activities
A7J05_RS27125	COG0275	rRNA processing
A7J05_RS27135	COG0768	penicillin binding
A7J05_RS27140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7J05_RS27150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7J05_RS27155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7J05_RS27165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7J05_RS27170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A7J05_RS27175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7J05_RS27180	COG1496	oxidoreductase activity
A7J05_RS27190	COG1799	cell septum assembly
A7J05_RS27200	COG3599	regulation of cell shape
A7J05_RS27205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7J05_RS27215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7J05_RS27265	COG0587	DNA-directed DNA polymerase activity
A7J05_RS27275	COG1432	Conserved Protein
A7J05_RS27295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7J05_RS27300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7J05_RS27315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7J05_RS27320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7J05_RS27325	COG0131	Imidazoleglycerol-phosphate dehydratase
A7J05_RS27330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7J05_RS27335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7J05_RS27340	COG0251	oxidation-reduction process
A7J05_RS27345	COG0107	imidazoleglycerol-phosphate synthase activity
A7J05_RS27355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7J05_RS27360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7J05_RS27380	COG0134	indole-3-glycerol-phosphate synthase activity
A7J05_RS27385	COG0133	tryptophan synthase activity
A7J05_RS27390	COG0159	tryptophan synthase activity
A7J05_RS27400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7J05_RS27410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J05_RS27415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J05_RS27445	COG0070	glutamate synthase
A7J05_RS27445	COG0069	glutamate synthase activity
A7J05_RS27445	COG0067	glutamate synthase
A7J05_RS27460	COG1175	transmembrane transport
A7J05_RS27465	COG0395	ABC-type sugar transport system, permease component
A7J05_RS27470	COG2304	oxidoreductase activity
A7J05_RS27480	COG1278	Cold shock
A7J05_RS27490	COG1357	PFAM Pentapeptide repeats (8 copies)
A7J05_RS27505	COG0366	Alpha amylase catalytic
A7J05_RS27505	COG1470	cell adhesion involved in biofilm formation
A7J05_RS27520	COG1605	Chorismate mutase
A7J05_RS27520	COG0287	Prephenate dehydrogenase
A7J05_RS27530	COG0702	epimerase
A7J05_RS27550	COG0737	Belongs to the 5'-nucleotidase family
A7J05_RS27585	COG0411	ABC transporter
A7J05_RS27615	COG2050	protein possibly involved in aromatic compounds catabolism
A7J05_RS27645	COG1643	Atp-dependent helicase
A7J05_RS27670	COG0237	dephospho-CoA kinase activity
A7J05_RS27685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7J05_RS27700	COG2267	carboxylic ester hydrolase activity
A7J05_RS27720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7J05_RS27750	COG0402	S-adenosylhomocysteine deaminase activity
A7J05_RS27810	COG0598	Magnesium transport protein CorA
A7J05_RS27825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7J05_RS27830	COG0584	glycerophosphoryl diester phosphodiesterase
A7J05_RS27840	COG0556	nucleotide-excision repair
A7J05_RS27860	COG0387	Pfam Sodium calcium exchanger
A7J05_RS27865	COG1619	proteins homologs of microcin C7 resistance protein MccF
A7J05_RS27870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7J05_RS27885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7J05_RS27920	COG0322	excinuclease ABC activity
A7J05_RS27925	COG1660	Displays ATPase and GTPase activities
A7J05_RS27930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A7J05_RS27935	COG1481	regulation of sporulation
A7J05_RS27945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7J05_RS27950	COG0126	phosphoglycerate kinase activity
A7J05_RS27955	COG0149	triose-phosphate isomerase activity
A7J05_RS27960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7J05_RS27970	COG0166	Belongs to the GPI family
A7J05_RS27980	COG0363	glucosamine-6-phosphate deaminase activity
A7J05_RS27995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7J05_RS28005	COG0109	protoheme IX farnesyltransferase activity
A7J05_RS28045	COG0719	Fe-S assembly protein
A7J05_RS28055	COG0396	ATPase activity
A7J05_RS28060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7J05_RS28065	COG0822	iron-sulfur transferase activity
A7J05_RS28080	COG3226	Transcriptional regulator
A7J05_RS28085	COG2171	N-acyltransferase activity
A7J05_RS28090	COG1595	DNA-templated transcription, initiation
A7J05_RS28100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J05_RS28175	COG0395	ABC-type sugar transport system, permease component
A7J05_RS28190	COG1349	DNA-binding transcription factor activity
A7J05_RS28195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7J05_RS28200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J05_RS28230	COG1695	Transcriptional regulator
A7J05_RS28240	COG0768	penicillin binding
A7J05_RS28245	COG2197	response regulator
A7J05_RS28250	COG4585	Histidine kinase
A7J05_RS28265	COG1414	Transcriptional regulator
A7J05_RS28285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7J05_RS28290	COG5285	phytanoyl-CoA dioxygenase
A7J05_RS28295	COG1917	Cupin 2, conserved barrel domain protein
A7J05_RS28300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS28305	COG0456	acetyltransferase
A7J05_RS28310	COG2318	DinB family
A7J05_RS28315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7J05_RS28340	COG1797	cobyrinic acid a,c-diamide synthase activity
A7J05_RS28355	COG1492	cobalamin metabolic process
A7J05_RS28360	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A7J05_RS28375	COG0235	Class ii aldolase
A7J05_RS28395	COG0488	(ABC) transporter
A7J05_RS28445	COG3387	PFAM Glycoside hydrolase 15-related
A7J05_RS28470	COG0326	Molecular chaperone. Has ATPase activity
A7J05_RS28515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J05_RS28520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7J05_RS28540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7J05_RS28555	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS28560	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7J05_RS28570	COG2186	Transcriptional regulator
A7J05_RS28590	COG0560	Phosphoserine phosphatase
A7J05_RS28590	COG3830	Belongs to the UPF0237 family
A7J05_RS28600	COG1716	ATPase activity
A7J05_RS28600	COG1131	(ABC) transporter
A7J05_RS28600	COG0842	Transport permease protein
A7J05_RS28610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7J05_RS28615	COG4221	oxidoreductase activity
A7J05_RS28620	COG4585	Histidine kinase
A7J05_RS28625	COG2197	response regulator
A7J05_RS28645	COG1119	ATPase activity
A7J05_RS28665	COG1881	PFAM PEBP family protein
A7J05_RS28675	COG2094	Belongs to the DNA glycosylase MPG family
A7J05_RS28710	COG0647	UMP catabolic process
A7J05_RS28720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS28725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS28730	COG1120	ATPase activity
A7J05_RS28750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7J05_RS28760	COG0497	DNA recombination
A7J05_RS28765	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS28775	COG1309	transcriptional regulator
A7J05_RS28785	COG1902	pentaerythritol trinitrate reductase activity
A7J05_RS28790	COG3387	PFAM Glycoside hydrolase 15-related
A7J05_RS28795	COG0504	CTP synthase activity
A7J05_RS28800	COG0494	nUDIX hydrolase
A7J05_RS28810	COG0686	Belongs to the AlaDH PNT family
A7J05_RS28825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A7J05_RS28830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A7J05_RS28835	COG1187	pseudouridine synthase activity
A7J05_RS28860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7J05_RS28870	COG1160	GTP binding
A7J05_RS28900	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS28925	COG0671	phosphoesterase, PA-phosphatase related
A7J05_RS28935	COG0477	Major facilitator Superfamily
A7J05_RS28940	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS28945	COG1799	cell septum assembly
A7J05_RS28975	COG0587	DNA-directed DNA polymerase activity
A7J05_RS28980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7J05_RS28995	COG4565	transcriptional regulatory protein
A7J05_RS29025	COG0456	acetyltransferase
A7J05_RS29025	COG0454	-acetyltransferase
A7J05_RS29030	COG1725	Transcriptional regulator
A7J05_RS29035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7J05_RS29050	COG1649	PFAM Uncharacterised BCR, COG1649
A7J05_RS29050	COG0726	polysaccharide deacetylase
A7J05_RS29060	COG0463	Glycosyl transferase, family 2
A7J05_RS29075	COG2755	lipolytic protein G-D-S-L family
A7J05_RS29080	COG0515	serine threonine protein kinase
A7J05_RS29110	COG2188	Transcriptional regulator
A7J05_RS29115	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A7J05_RS29120	COG1309	transcriptional regulator
A7J05_RS29125	COG2851	Citrate transporter
A7J05_RS29160	COG0640	Transcriptional regulator
A7J05_RS29170	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS29190	COG0789	Transcriptional regulator
A7J05_RS29220	COG0477	Major facilitator Superfamily
A7J05_RS29240	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS29270	COG2149	membrane
A7J05_RS29275	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7J05_RS29285	COG3573	Dehydrogenase
A7J05_RS29305	COG3265	gluconokinase activity
A7J05_RS29315	COG3012	SEC-C Motif Domain Protein
A7J05_RS29325	COG0662	Cupin 2, conserved barrel domain protein
A7J05_RS29340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A7J05_RS29345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A7J05_RS29350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A7J05_RS29360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J05_RS29390	COG0667	Aldo Keto reductase
A7J05_RS29395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS29405	COG0598	Magnesium transport protein CorA
A7J05_RS29410	COG0406	alpha-ribazole phosphatase activity
A7J05_RS29425	COG0215	cysteine-tRNA ligase activity
A7J05_RS29435	COG2186	Transcriptional regulator
A7J05_RS29445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7J05_RS29450	COG0402	S-adenosylhomocysteine deaminase activity
A7J05_RS29460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7J05_RS29465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7J05_RS29470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7J05_RS29475	COG1414	Transcriptional regulator
A7J05_RS29480	COG0646	methionine synthase
A7J05_RS29480	COG1410	methionine synthase
A7J05_RS29490	COG0747	negative chemotaxis
A7J05_RS29495	COG2197	response regulator
A7J05_RS29530	COG1222	aaa ATPase
A7J05_RS29535	COG4122	O-methyltransferase activity
A7J05_RS29550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A7J05_RS29555	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A7J05_RS29560	COG1609	Transcriptional regulator
A7J05_RS29570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A7J05_RS29575	COG0545	Peptidyl-prolyl cis-trans isomerase
A7J05_RS29585	COG2378	regulation of single-species biofilm formation
A7J05_RS29605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7J05_RS29610	COG0805	protein transport
A7J05_RS29665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7J05_RS29670	COG0517	IMP dehydrogenase activity
A7J05_RS29670	COG4175	Glycine betaine
A7J05_RS29710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7J05_RS29715	COG0531	amino acid
A7J05_RS29725	COG0174	glutamine synthetase
A7J05_RS29730	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS29740	COG0560	Phosphoserine phosphatase
A7J05_RS29740	COG3830	Belongs to the UPF0237 family
A7J05_RS29775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7J05_RS29780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7J05_RS29785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7J05_RS29790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7J05_RS29795	COG5002	protein histidine kinase activity
A7J05_RS29800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7J05_RS29805	COG0072	phenylalanine-tRNA ligase activity
A7J05_RS29805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7J05_RS29835	COG1649	PFAM Uncharacterised BCR, COG1649
A7J05_RS29845	COG0697	spore germination
A7J05_RS29860	COG0667	Aldo Keto reductase
A7J05_RS29865	COG0477	Major facilitator Superfamily
A7J05_RS29875	COG2838	Isocitrate dehydrogenase
A7J05_RS29900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J05_RS29910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7J05_RS29915	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A7J05_RS29920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7J05_RS29925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7J05_RS29930	COG1438	arginine binding
A7J05_RS29935	COG0385	Bile acid
A7J05_RS29945	COG0165	Argininosuccinate lyase
A7J05_RS29960	COG0477	Major facilitator Superfamily
A7J05_RS29965	COG0204	Acyl-transferase
A7J05_RS29965	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS29970	COG0584	glycerophosphoryl diester phosphodiesterase
A7J05_RS29995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7J05_RS30000	COG2011	ABC-type metal ion transport system permease component
A7J05_RS30010	COG1464	Belongs to the NlpA lipoprotein family
A7J05_RS30025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A7J05_RS30030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7J05_RS30030	COG1648	precorrin-2 dehydrogenase activity
A7J05_RS30085	COG0512	Glutamine amidotransferase of anthranilate synthase
A7J05_RS30085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7J05_RS30145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7J05_RS30160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7J05_RS30180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7J05_RS30185	COG1560	Kdo2-lipid A biosynthetic process
A7J05_RS30190	COG0438	transferase activity, transferring glycosyl groups
A7J05_RS30200	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A7J05_RS30205	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A7J05_RS30210	COG0217	transcriptional regulatory protein
A7J05_RS30215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A7J05_RS30220	COG0632	four-way junction helicase activity
A7J05_RS30225	COG2255	four-way junction helicase activity
A7J05_RS30235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7J05_RS30240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7J05_RS30245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7J05_RS30250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7J05_RS30255	COG1196	nuclear chromosome segregation
A7J05_RS30270	COG0124	histidyl-tRNA synthetase
A7J05_RS30285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7J05_RS30305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7J05_RS30310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A7J05_RS30315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7J05_RS30320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7J05_RS30325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7J05_RS30330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7J05_RS30335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7J05_RS30345	COG0006	proline dipeptidase activity
A7J05_RS30350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7J05_RS30355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7J05_RS30365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A7J05_RS30370	COG0540	Belongs to the ATCase OTCase family
A7J05_RS30375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7J05_RS30385	COG0505	Belongs to the CarA family
A7J05_RS30390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7J05_RS30395	COG0167	dihydroorotate dehydrogenase activity
A7J05_RS30400	COG0284	orotidine-5'-phosphate decarboxylase activity
A7J05_RS30410	COG0194	GDP metabolic process
A7J05_RS30425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7J05_RS30440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7J05_RS30450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7J05_RS30455	COG2390	Transcriptional regulator
A7J05_RS30470	COG0531	amino acid
A7J05_RS30485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J05_RS30505	COG2233	PERMEase
A7J05_RS30510	COG0738	Major facilitator superfamily
A7J05_RS30515	COG1940	carbohydrate kinase activity
A7J05_RS30515	COG1846	Transcriptional regulator
A7J05_RS30535	COG3201	nicotinamide mononucleotide transporter
A7J05_RS30540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7J05_RS30540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7J05_RS30545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7J05_RS30550	COG0140	phosphoribosyl-ATP diphosphatase activity
A7J05_RS30555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7J05_RS30600	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS30625	COG0463	Glycosyl transferase, family 2
A7J05_RS30640	COG2270	Major facilitator Superfamily
A7J05_RS30650	COG2364	Membrane
A7J05_RS30655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J05_RS30680	COG1984	allophanate hydrolase subunit 2
A7J05_RS30685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7J05_RS30690	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7J05_RS30695	COG4336	lyase activity
A7J05_RS30700	COG2814	Major facilitator Superfamily
A7J05_RS30730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS30745	COG1414	Transcriptional regulator
A7J05_RS30755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7J05_RS30785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7J05_RS30790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7J05_RS30795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS30805	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A7J05_RS30820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7J05_RS30830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7J05_RS30865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A7J05_RS30885	COG1716	ATPase activity
A7J05_RS30905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7J05_RS30915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7J05_RS30915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7J05_RS30950	COG0384	phenazine biosynthesis protein PhzF
A7J05_RS30960	COG2890	protein-(glutamine-N5) methyltransferase activity
A7J05_RS30980	COG0697	spore germination
A7J05_RS30995	COG0697	spore germination
A7J05_RS31050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7J05_RS31075	COG0673	inositol 2-dehydrogenase activity
A7J05_RS31080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7J05_RS31105	COG4195	phage-related replication protein
A7J05_RS31110	COG1968	undecaprenyl-diphosphatase activity
A7J05_RS31125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7J05_RS31185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J05_RS31210	COG0252	asparaginase activity
A7J05_RS31215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J05_RS31250	COG3485	protocatechuate 3,4-dioxygenase
A7J05_RS31275	COG0531	amino acid
A7J05_RS31280	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS31285	COG1335	isochorismatase
A7J05_RS31300	COG2706	6-phosphogluconolactonase activity
A7J05_RS31315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7J05_RS31325	COG2040	homocysteine
A7J05_RS31335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS31350	COG1940	carbohydrate kinase activity
A7J05_RS31370	COG1902	pentaerythritol trinitrate reductase activity
A7J05_RS31395	COG1309	transcriptional regulator
A7J05_RS31405	COG0671	phosphoesterase, PA-phosphatase related
A7J05_RS31415	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A7J05_RS31435	COG1252	NADH dehydrogenase
A7J05_RS31450	COG0584	glycerophosphoryl diester phosphodiesterase
A7J05_RS31455	COG0671	phosphoesterase, PA-phosphatase related
A7J05_RS31465	COG0596	Alpha beta hydrolase
A7J05_RS31470	COG1597	lipid kinase activity
A7J05_RS31480	COG2376	Dihydroxyacetone kinase
A7J05_RS31485	COG1846	Transcriptional regulator
A7J05_RS31485	COG0456	acetyltransferase
A7J05_RS31510	COG1191	sigma factor activity
A7J05_RS31525	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A7J05_RS31545	COG2172	sigma factor antagonist activity
A7J05_RS31550	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J05_RS31555	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J05_RS31570	COG1191	sigma factor activity
A7J05_RS31600	COG0204	Acyl-transferase
A7J05_RS31620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A7J05_RS31635	COG0515	serine threonine protein kinase
A7J05_RS31650	COG3345	alpha-galactosidase
A7J05_RS31670	COG1660	Displays ATPase and GTPase activities
A7J05_RS31680	COG0445	tRNA wobble uridine modification
A7J05_RS31700	COG1595	DNA-templated transcription, initiation
A7J05_RS31705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J05_RS31715	COG1940	carbohydrate kinase activity
A7J05_RS31770	COG1349	DNA-binding transcription factor activity
A7J05_RS31805	COG1215	transferase activity, transferring glycosyl groups
A7J05_RS31810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7J05_RS31830	COG2813	Specifically methylates the guanine in position
A7J05_RS31835	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A7J05_RS31840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7J05_RS31845	COG1902	pentaerythritol trinitrate reductase activity
A7J05_RS31845	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7J05_RS31880	COG1461	Dihydroxyacetone kinase
A7J05_RS31885	COG2376	Dihydroxyacetone kinase
A7J05_RS31915	COG1174	glycine betaine transport
A7J05_RS31920	COG1174	glycine betaine transport
A7J05_RS31935	COG1556	Lactate utilization protein
A7J05_RS31940	COG1139	Iron-sulfur cluster binding protein
A7J05_RS31945	COG0247	lactate metabolic process
A7J05_RS31980	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS31985	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS31995	COG0601	transmembrane transport
A7J05_RS32000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J05_RS32005	COG0444	Belongs to the ABC transporter superfamily
A7J05_RS32050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7J05_RS32065	COG0019	diaminopimelate decarboxylase activity
A7J05_RS32095	COG2814	Major facilitator Superfamily
A7J05_RS32110	COG0659	secondary active sulfate transmembrane transporter activity
A7J05_RS32120	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS32155	COG0366	Alpha amylase catalytic
A7J05_RS32165	COG3281	Trehalose synthase
A7J05_RS32170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7J05_RS32185	COG1191	sigma factor activity
A7J05_RS32195	COG3433	isochorismatase activity
A7J05_RS32195	COG1535	isochorismatase
A7J05_RS32200	COG2375	cellular response to nickel ion
A7J05_RS32205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7J05_RS32210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS32215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS32220	COG1120	ATPase activity
A7J05_RS32270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7J05_RS32280	COG2197	response regulator
A7J05_RS32330	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS32350	COG1940	carbohydrate kinase activity
A7J05_RS32355	COG1070	Carbohydrate kinase
A7J05_RS32360	COG2115	Belongs to the xylose isomerase family
A7J05_RS32375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7J05_RS32380	COG3239	Fatty acid desaturase
A7J05_RS32430	COG2018	Roadblock/LC7 domain
A7J05_RS32435	COG1946	Acyl-CoA thioesterase
A7J05_RS32450	COG1132	(ABC) transporter
A7J05_RS32455	COG1132	(ABC) transporter
A7J05_RS32460	COG1132	(ABC) transporter
A7J05_RS32465	COG1132	(ABC) transporter
A7J05_RS32485	COG0277	FAD linked oxidase domain protein
A7J05_RS32490	COG1846	Transcriptional regulator
A7J05_RS32495	COG1132	(ABC) transporter
A7J05_RS32505	COG2318	DinB family
A7J05_RS32510	COG2072	flavoprotein involved in K transport
A7J05_RS32515	COG0432	Pfam Uncharacterised protein family UPF0047
A7J05_RS32530	COG1012	belongs to the aldehyde dehydrogenase family
A7J05_RS32550	COG2080	2 iron, 2 sulfur cluster binding
A7J05_RS32555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A7J05_RS32560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7J05_RS32565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A7J05_RS32565	COG3608	succinylglutamate desuccinylase aspartoacylase
A7J05_RS32580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS32580	COG0723	plastoquinol--plastocyanin reductase activity
A7J05_RS32615	COG1832	CoA-binding protein
A7J05_RS32650	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A7J05_RS32660	COG1739	Uncharacterized protein family UPF0029
A7J05_RS32665	COG0420	3'-5' exonuclease activity
A7J05_RS32670	COG0419	ATPase involved in DNA repair
A7J05_RS32685	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS32700	COG0626	cystathionine gamma-synthase activity
A7J05_RS32715	COG0346	lactoylglutathione lyase activity
A7J05_RS32725	COG1595	DNA-templated transcription, initiation
A7J05_RS32730	COG2188	Transcriptional regulator
A7J05_RS32735	COG1940	carbohydrate kinase activity
A7J05_RS32740	COG2197	response regulator
A7J05_RS32745	COG4585	Histidine kinase
A7J05_RS32765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A7J05_RS32785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7J05_RS32810	COG0577	efflux transmembrane transporter activity
A7J05_RS32810	COG1136	(ABC) transporter
A7J05_RS32815	COG1136	(ABC) transporter
A7J05_RS32815	COG0577	efflux transmembrane transporter activity
A7J05_RS32830	COG2226	methyltransferase
A7J05_RS32835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7J05_RS32840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7J05_RS32845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7J05_RS32885	COG0740	serine-type endopeptidase activity
A7J05_RS32900	COG1309	transcriptional regulator
A7J05_RS32905	COG0831	urea catabolic process
A7J05_RS32910	COG0832	Belongs to the urease beta subunit family
A7J05_RS32915	COG0804	urea catabolic process
A7J05_RS32920	COG0830	nickel cation binding
A7J05_RS32925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A7J05_RS32930	COG0829	nickel cation binding
A7J05_RS32940	COG0204	Acyl-transferase
A7J05_RS32955	COG0205	6-phosphofructokinase activity
A7J05_RS32960	COG3442	glutamine amidotransferase
A7J05_RS32970	COG0242	peptide deformylase activity
A7J05_RS32980	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS33005	COG2814	Major facilitator Superfamily
A7J05_RS33025	COG0367	asparagine synthase
A7J05_RS33040	COG0583	DNA-binding transcription factor activity
A7J05_RS33045	COG4941	Belongs to the sigma-70 factor family
A7J05_RS33070	COG2409	Drug exporters of the RND superfamily
A7J05_RS33085	COG2175	clavaminate synthase activity
A7J05_RS33095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J05_RS33125	COG2226	methyltransferase
A7J05_RS33145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7J05_RS33150	COG2409	Drug exporters of the RND superfamily
A7J05_RS33155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7J05_RS33180	COG2755	lipolytic protein G-D-S-L family
A7J05_RS33195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7J05_RS33200	COG1309	transcriptional regulator
A7J05_RS33220	COG0739	heme binding
A7J05_RS33230	COG2340	Cysteine-rich secretory protein family
A7J05_RS33245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7J05_RS33275	COG1228	amidohydrolase
A7J05_RS33310	COG0693	protein deglycase activity
A7J05_RS33345	COG1295	ribonuclease BN
A7J05_RS33365	COG0009	L-threonylcarbamoyladenylate synthase
A7J05_RS33385	COG2318	DinB family
A7J05_RS33410	COG3708	Transcriptional regulator
A7J05_RS33410	COG2207	Transcriptional regulator
A7J05_RS33425	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A7J05_RS33445	COG0142	geranyltranstransferase activity
A7J05_RS33470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS33490	COG0310	cobalt ion transport
A7J05_RS33495	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
A7J05_RS33500	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A7J05_RS33505	COG1122	ATPase activity
A7J05_RS33535	COG3896	Chloramphenicol phosphotransferase-like protein
A7J05_RS33590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7J05_RS33595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J05_RS33595	COG1263	PTS System
A7J05_RS33695	COG0789	Transcriptional regulator
A7J05_RS33705	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A7J05_RS33720	COG0655	NAD(P)H dehydrogenase (quinone) activity
A7J05_RS33730	COG3973	AAA domain
A7J05_RS33740	COG0475	glutathione-regulated potassium exporter activity
A7J05_RS33760	COG4106	trans-aconitate 2-methyltransferase activity
A7J05_RS33770	COG1295	ribonuclease BN
A7J05_RS33780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7J05_RS33785	COG1120	ATPase activity
A7J05_RS33790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7J05_RS33815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J05_RS33820	COG0395	ABC-type sugar transport system, permease component
A7J05_RS33840	COG1349	DNA-binding transcription factor activity
A7J05_RS33845	COG0784	Response regulator, receiver
A7J05_RS33850	COG4251	negative regulation of phosphorylation
A7J05_RS33860	COG0667	Aldo Keto reductase
A7J05_RS33900	COG1132	(ABC) transporter
A7J05_RS33920	COG0667	Aldo Keto reductase
A7J05_RS33925	COG4566	intracellular signal transduction
A7J05_RS33930	COG2124	cytochrome p450
A7J05_RS33980	COG0477	Major facilitator Superfamily
A7J05_RS33985	COG0513	Belongs to the DEAD box helicase family
A7J05_RS34005	COG0006	proline dipeptidase activity
A7J05_RS34070	COG3629	intracellular signal transduction
A7J05_RS34070	COG3903	Transcriptional regulator
A7J05_RS34075	COG0596	Alpha beta hydrolase
A7J05_RS34100	COG0488	(ABC) transporter
A7J05_RS34115	COG1554	hydrolase, family 65, central catalytic
A7J05_RS34145	COG0640	Transcriptional regulator
A7J05_RS34150	COG0346	lactoylglutathione lyase activity
A7J05_RS34170	COG1595	DNA-templated transcription, initiation
A7J05_RS34180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J05_RS34215	COG0475	glutathione-regulated potassium exporter activity
A7J05_RS34230	COG4106	trans-aconitate 2-methyltransferase activity
A7J05_RS34240	COG2197	response regulator
A7J05_RS34280	COG3591	Belongs to the peptidase S1B family
A7J05_RS34320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7J05_RS34390	COG1309	transcriptional regulator
A7J05_RS34415	COG1051	belongs to the nudix hydrolase family
A7J05_RS34435	COG2124	cytochrome p450
A7J05_RS34495	COG3629	intracellular signal transduction
A7J05_RS34500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS34505	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A7J05_RS34515	COG0825	malonyl-CoA metabolic process
A7J05_RS34515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7J05_RS34520	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS34530	COG2186	Transcriptional regulator
A7J05_RS34540	COG0583	DNA-binding transcription factor activity
A7J05_RS34635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS34640	COG1120	ATPase activity
A7J05_RS34645	COG1335	isochorismatase
A7J05_RS34650	COG3848	Pyruvate phosphate dikinase
A7J05_RS34650	COG0574	Belongs to the PEP-utilizing enzyme family
A7J05_RS34655	COG3629	intracellular signal transduction
A7J05_RS34655	COG3903	Transcriptional regulator
A7J05_RS34670	COG0110	maltose O-acetyltransferase activity
A7J05_RS34675	COG0488	(ABC) transporter
A7J05_RS34685	COG4733	cellulase activity
A7J05_RS34685	COG5297	Belongs to the glycosyl hydrolase family 6
A7J05_RS34700	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS34705	COG2072	flavoprotein involved in K transport
A7J05_RS34765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A7J05_RS34790	COG4585	Histidine kinase
A7J05_RS34795	COG2197	response regulator
A7J05_RS34830	COG2186	Transcriptional regulator
A7J05_RS34850	COG0596	Alpha beta hydrolase
A7J05_RS34865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A7J05_RS34875	COG0154	amidase activity
A7J05_RS34900	COG0714	Associated with various cellular activities
A7J05_RS34925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7J05_RS34935	COG0798	PFAM Bile acid sodium symporter
A7J05_RS34940	COG2072	flavoprotein involved in K transport
A7J05_RS34945	COG0659	secondary active sulfate transmembrane transporter activity
A7J05_RS34950	COG0789	Transcriptional regulator
A7J05_RS34955	COG1595	DNA-templated transcription, initiation
A7J05_RS34980	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A7J05_RS34990	COG2226	methyltransferase
A7J05_RS35015	COG1472	Belongs to the glycosyl hydrolase 3 family
A7J05_RS35020	COG1609	Transcriptional regulator
A7J05_RS35035	COG0829	nickel cation binding
A7J05_RS35040	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A7J05_RS35050	COG0804	urea catabolic process
A7J05_RS35055	COG0832	Belongs to the urease beta subunit family
A7J05_RS35055	COG0831	urea catabolic process
A7J05_RS35070	COG2391	methyltransferase activity
A7J05_RS35080	COG2050	protein possibly involved in aromatic compounds catabolism
A7J05_RS35095	COG2226	methyltransferase
A7J05_RS35100	COG0596	Alpha beta hydrolase
A7J05_RS35105	COG4552	Acetyltransferase involved in intracellular survival and related
A7J05_RS35110	COG2197	response regulator
A7J05_RS35120	COG0738	Major facilitator superfamily
A7J05_RS35130	COG3226	Transcriptional regulator
A7J05_RS35140	COG2318	DinB family
A7J05_RS35155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS35165	COG3483	tryptophan 2,3-dioxygenase activity
A7J05_RS35180	COG2130	NADP-dependent
A7J05_RS35275	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS35285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J05_RS35335	COG0596	Alpha beta hydrolase
A7J05_RS35350	COG0640	Transcriptional regulator
A7J05_RS35375	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A7J05_RS35380	COG1960	acyl-CoA dehydrogenase activity
A7J05_RS35385	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS35390	COG1309	transcriptional regulator
A7J05_RS35420	COG0017	Asparaginyl-tRNA synthetase
A7J05_RS35445	COG2124	cytochrome p450
A7J05_RS35460	COG3977	Valine--pyruvate aminotransferase
A7J05_RS35490	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS35490	COG0604	alcohol dehydrogenase
A7J05_RS35490	COG3321	synthase
A7J05_RS35510	COG0076	glutamate decarboxylase activity
A7J05_RS35520	COG2267	carboxylic ester hydrolase activity
A7J05_RS35610	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7J05_RS35615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J05_RS35620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7J05_RS35625	COG1733	regulation of RNA biosynthetic process
A7J05_RS35665	COG4191	Histidine kinase
A7J05_RS35700	COG4585	Histidine kinase
A7J05_RS35705	COG2197	response regulator
A7J05_RS35760	COG0477	Major facilitator Superfamily
A7J05_RS35765	COG0402	S-adenosylhomocysteine deaminase activity
A7J05_RS35770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7J05_RS35775	COG1755	Isoprenylcysteine carboxyl methyltransferase
A7J05_RS35795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7J05_RS35805	COG0604	alcohol dehydrogenase
A7J05_RS35825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS35830	COG0477	Major facilitator Superfamily
A7J05_RS35835	COG2197	response regulator
A7J05_RS35895	COG0531	amino acid
A7J05_RS35900	COG4977	sequence-specific DNA binding
A7J05_RS35910	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS35925	COG0402	S-adenosylhomocysteine deaminase activity
A7J05_RS35935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7J05_RS35940	COG0583	DNA-binding transcription factor activity
A7J05_RS35965	COG1335	isochorismatase
A7J05_RS35975	COG2205	protein histidine kinase activity
A7J05_RS35980	COG0745	RESPONSE REGULATOR receiver
A7J05_RS35990	COG1131	(ABC) transporter
A7J05_RS35995	COG1959	2 iron, 2 sulfur cluster binding
A7J05_RS36000	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS36010	COG0640	Transcriptional regulator
A7J05_RS36045	COG0789	Transcriptional regulator
A7J05_RS36075	COG1309	transcriptional regulator
A7J05_RS36115	COG0142	geranyltranstransferase activity
A7J05_RS36145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J05_RS36175	COG2124	cytochrome p450
A7J05_RS36195	COG3251	PFAM MbtH domain protein
A7J05_RS36240	COG2205	protein histidine kinase activity
A7J05_RS36245	COG0745	RESPONSE REGULATOR receiver
A7J05_RS36255	COG1686	Belongs to the peptidase S11 family
A7J05_RS36260	COG1116	anion transmembrane transporter activity
A7J05_RS36275	COG0456	acetyltransferase
A7J05_RS36285	COG2814	Major facilitator Superfamily
A7J05_RS36345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A7J05_RS36350	COG0515	serine threonine protein kinase
A7J05_RS36350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7J05_RS36370	COG0583	DNA-binding transcription factor activity
A7J05_RS36385	COG0590	tRNA wobble adenosine to inosine editing
A7J05_RS36395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7J05_RS36410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7J05_RS36460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7J05_RS36465	COG0583	DNA-binding transcription factor activity
A7J05_RS36490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7J05_RS36555	COG4585	Histidine kinase
A7J05_RS36560	COG2197	response regulator
A7J05_RS36570	COG0596	Alpha beta hydrolase
A7J05_RS36575	COG2267	carboxylic ester hydrolase activity
A7J05_RS36580	COG3903	Transcriptional regulator
A7J05_RS36580	COG3629	intracellular signal transduction
A7J05_RS36595	COG0393	Putative heavy-metal-binding
A7J05_RS36640	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS36655	COG3693	PFAM glycoside hydrolase, family 10
A7J05_RS36715	COG0477	Major facilitator Superfamily
A7J05_RS36770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7J05_RS36790	COG5297	Belongs to the glycosyl hydrolase family 6
A7J05_RS36800	COG3397	chitin binding
A7J05_RS36835	COG0702	epimerase
A7J05_RS36865	COG0667	Aldo Keto reductase
A7J05_RS36870	COG1309	transcriptional regulator
A7J05_RS36900	COG1073	alpha beta
A7J05_RS36915	COG3293	Transposase
A7J05_RS36935	COG2022	thiamine diphosphate biosynthetic process
A7J05_RS36935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J05_RS36945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7J05_RS36955	COG0277	FAD linked oxidase domain protein
A7J05_RS36995	COG1309	transcriptional regulator
A7J05_RS37005	COG0667	Aldo Keto reductase
A7J05_RS37035	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS37040	COG1309	transcriptional regulator
A7J05_RS37085	COG2124	cytochrome p450
A7J05_RS37090	COG0702	epimerase
A7J05_RS37130	COG2070	2-Nitropropane dioxygenase
A7J05_RS37140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J05_RS37155	COG0076	glutamate decarboxylase activity
A7J05_RS37175	COG0667	Aldo Keto reductase
A7J05_RS37190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J05_RS37205	COG2197	response regulator
A7J05_RS37210	COG3629	intracellular signal transduction
A7J05_RS37210	COG3903	Transcriptional regulator
A7J05_RS37235	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS37240	COG0318	PFAM AMP-dependent synthetase and ligase
A7J05_RS37250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7J05_RS37260	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS37280	COG3321	synthase
A7J05_RS37280	COG0604	alcohol dehydrogenase
A7J05_RS37280	COG1028	Short-chain dehydrogenase reductase Sdr
A7J05_RS37305	COG3251	PFAM MbtH domain protein
A7J05_RS37315	COG3958	Transketolase
A7J05_RS37320	COG3959	Transketolase, thiamine diphosphate binding domain
A7J05_RS37330	COG2197	response regulator
A7J05_RS37355	COG0527	aspartate kinase activity
A7J05_RS37385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J05_RS37390	COG2175	clavaminate synthase activity
A7J05_RS37425	COG3547	Transposase (IS116 IS110 IS902 family)
A7J05_RS37470	COG3293	Transposase
A7J05_RS37480	COG1309	transcriptional regulator
A7J05_RS37485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J05_RS37555	COG1595	DNA-templated transcription, initiation
A7J05_RS37640	COG3293	Transposase