locus-tag	class	description
I1A49_RS00030	COG2197	response regulator
I1A49_RS00035	COG4585	Histidine kinase
I1A49_RS00055	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS00080	COG1794	racemase activity, acting on amino acids and derivatives
I1A49_RS00115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I1A49_RS00145	COG3345	alpha-galactosidase
I1A49_RS00150	COG3507	Belongs to the glycosyl hydrolase 43 family
I1A49_RS00170	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS00195	COG1309	transcriptional regulator
I1A49_RS00250	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS00285	COG0109	protoheme IX farnesyltransferase activity
I1A49_RS00300	COG2837	iron assimilation
I1A49_RS00315	COG4221	oxidoreductase activity
I1A49_RS00365	COG1309	transcriptional regulator
I1A49_RS00380	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS00415	COG1522	sequence-specific DNA binding
I1A49_RS00430	COG2197	response regulator
I1A49_RS00435	COG0300	oxidoreductase activity
I1A49_RS00440	COG0583	DNA-binding transcription factor activity
I1A49_RS00445	COG0456	acetyltransferase
I1A49_RS00480	COG1802	Transcriptional regulator
I1A49_RS00485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS00505	COG2132	Multicopper oxidase
I1A49_RS00525	COG3321	synthase
I1A49_RS00525	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS00525	COG0604	alcohol dehydrogenase
I1A49_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS00545	COG0346	lactoylglutathione lyase activity
I1A49_RS00550	COG0640	Transcriptional regulator
I1A49_RS00585	COG2376	Dihydroxyacetone kinase
I1A49_RS00590	COG2376	Dihydroxyacetone kinase
I1A49_RS00595	COG0477	Major facilitator Superfamily
I1A49_RS00600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS00625	COG0515	serine threonine protein kinase
I1A49_RS00625	COG2815	serine threonine protein kinase
I1A49_RS00650	COG3069	C4-dicarboxylate transmembrane transporter activity
I1A49_RS00655	COG0405	Gamma-glutamyltransferase
I1A49_RS00670	COG2508	Transcriptional regulator
I1A49_RS00700	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I1A49_RS00705	COG3321	synthase
I1A49_RS00705	COG0604	alcohol dehydrogenase
I1A49_RS00720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS00725	COG3321	synthase
I1A49_RS00725	COG0604	alcohol dehydrogenase
I1A49_RS00760	COG3321	synthase
I1A49_RS00760	COG0604	alcohol dehydrogenase
I1A49_RS00775	COG3321	synthase
I1A49_RS00775	COG0604	alcohol dehydrogenase
I1A49_RS00835	COG0156	8-amino-7-oxononanoate synthase activity
I1A49_RS00870	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS00880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I1A49_RS00885	COG0585	pseudouridine synthase activity
I1A49_RS00890	COG0477	Major facilitator Superfamily
I1A49_RS00900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1A49_RS00930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A49_RS00935	COG2192	nodulation
I1A49_RS00960	COG0765	amino acid transport
I1A49_RS00975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1A49_RS00980	COG0402	S-adenosylhomocysteine deaminase activity
I1A49_RS00985	COG1472	Belongs to the glycosyl hydrolase 3 family
I1A49_RS00995	COG1175	transmembrane transport
I1A49_RS01015	COG3693	PFAM glycoside hydrolase, family 10
I1A49_RS01025	COG4266	Belongs to the allantoicase family
I1A49_RS01030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I1A49_RS01040	COG1953	Uracil, thiamine, allantoin
I1A49_RS01050	COG1414	Transcriptional regulator
I1A49_RS01060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I1A49_RS01070	COG3622	Belongs to the hyi family
I1A49_RS01075	COG2084	Dehydrogenase
I1A49_RS01080	COG3960	tartronate-semialdehyde synthase activity
I1A49_RS01085	COG1929	Belongs to the glycerate kinase type-1 family
I1A49_RS01105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1A49_RS01110	COG3387	PFAM Glycoside hydrolase 15-related
I1A49_RS01115	COG0129	dihydroxy-acid dehydratase activity
I1A49_RS01120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A49_RS01150	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS01155	COG1129	ABC transporter
I1A49_RS01160	COG1879	ABC-type sugar transport system periplasmic component
I1A49_RS01165	COG1609	Transcriptional regulator
I1A49_RS01170	COG2208	phosphoserine phosphatase activity
I1A49_RS01170	COG2770	Histidine kinase
I1A49_RS01230	COG1309	transcriptional regulator
I1A49_RS01250	COG4585	Histidine kinase
I1A49_RS01255	COG2197	response regulator
I1A49_RS01280	COG3321	synthase
I1A49_RS01280	COG0604	alcohol dehydrogenase
I1A49_RS01315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A49_RS01330	COG0596	Alpha beta hydrolase
I1A49_RS01340	COG0702	epimerase
I1A49_RS01355	COG0402	S-adenosylhomocysteine deaminase activity
I1A49_RS01360	COG0477	Major facilitator Superfamily
I1A49_RS01400	COG1619	proteins homologs of microcin C7 resistance protein MccF
I1A49_RS01425	COG2197	response regulator
I1A49_RS01430	COG4585	Histidine kinase
I1A49_RS01505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS01510	COG1116	anion transmembrane transporter activity
I1A49_RS01550	COG0537	adenosine 5'-monophosphoramidase activity
I1A49_RS01590	COG4106	trans-aconitate 2-methyltransferase activity
I1A49_RS01595	COG3250	beta-galactosidase activity
I1A49_RS01620	COG1914	H( )-stimulated, divalent metal cation uptake system
I1A49_RS01625	COG2140	Oxalate decarboxylase
I1A49_RS01645	COG2205	protein histidine kinase activity
I1A49_RS01650	COG0745	RESPONSE REGULATOR receiver
I1A49_RS01660	COG0477	Major facilitator Superfamily
I1A49_RS01665	COG1414	Transcriptional regulator
I1A49_RS01670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS01685	COG1126	abc transporter atp-binding protein
I1A49_RS01690	COG0765	amino acid transport
I1A49_RS01695	COG1737	Transcriptional regulator
I1A49_RS01700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I1A49_RS01715	COG1737	Transcriptional regulator
I1A49_RS01725	COG0436	Aminotransferase
I1A49_RS01730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A49_RS01740	COG3608	succinylglutamate desuccinylase aspartoacylase
I1A49_RS01745	COG3842	ATPase activity
I1A49_RS01750	COG1175	transmembrane transport
I1A49_RS01755	COG0395	ABC-type sugar transport system, permease component
I1A49_RS01760	COG1653	transport
I1A49_RS01770	COG0028	Belongs to the TPP enzyme family
I1A49_RS01775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I1A49_RS01785	COG0477	Major facilitator Superfamily
I1A49_RS01800	COG0363	glucosamine-6-phosphate deaminase activity
I1A49_RS01805	COG1486	melibiose metabolic process
I1A49_RS01825	COG1175	transmembrane transport
I1A49_RS01830	COG0395	ABC-type sugar transport system, permease component
I1A49_RS01850	COG3104	oligopeptide transport
I1A49_RS01855	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I1A49_RS01860	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I1A49_RS01865	COG3639	organic phosphonate transmembrane transporter activity
I1A49_RS01895	COG3627	carbon phosphorus lyase activity
I1A49_RS01900	COG4107	phosphonate C-P lyase system protein PhnK
I1A49_RS01905	COG1126	abc transporter atp-binding protein
I1A49_RS01910	COG3454	Phosphonate metabolism
I1A49_RS01945	COG1349	DNA-binding transcription factor activity
I1A49_RS01950	COG0531	amino acid
I1A49_RS01955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1A49_RS01990	COG0154	amidase activity
I1A49_RS01995	COG1733	regulation of RNA biosynthetic process
I1A49_RS02000	COG0604	alcohol dehydrogenase
I1A49_RS02005	COG2207	Transcriptional regulator
I1A49_RS02030	COG2226	methyltransferase
I1A49_RS02060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I1A49_RS02060	COG0519	Catalyzes the synthesis of GMP from XMP
I1A49_RS02130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I1A49_RS02135	COG2031	fatty acid transporter
I1A49_RS02140	COG2423	ornithine cyclodeaminase activity
I1A49_RS02145	COG1017	nitric oxide dioxygenase activity
I1A49_RS02145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1A49_RS02150	COG1802	Transcriptional regulator
I1A49_RS02155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1A49_RS02160	COG1309	transcriptional regulator
I1A49_RS02175	COG1301	dicarboxylic acid transport
I1A49_RS02180	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS02195	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS02205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS02210	COG0601	transmembrane transport
I1A49_RS02225	COG2195	Cleaves the N-terminal amino acid of tripeptides
I1A49_RS02230	COG0583	DNA-binding transcription factor activity
I1A49_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS02240	COG1609	Transcriptional regulator
I1A49_RS02260	COG4154	Belongs to the RbsD FucU family
I1A49_RS02285	COG1609	Transcriptional regulator
I1A49_RS02295	COG0477	Major facilitator Superfamily
I1A49_RS02310	COG1609	Transcriptional regulator
I1A49_RS02335	COG1175	transmembrane transport
I1A49_RS02340	COG0395	ABC-type sugar transport system, permease component
I1A49_RS02355	COG3661	Belongs to the glycosyl hydrolase 67 family
I1A49_RS02390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS02395	COG1024	Enoyl-CoA hydratase
I1A49_RS02430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A49_RS02440	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS02450	COG1929	Belongs to the glycerate kinase type-1 family
I1A49_RS02485	COG0640	Transcriptional regulator
I1A49_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS02530	COG4221	oxidoreductase activity
I1A49_RS02535	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A49_RS02570	COG0454	-acetyltransferase
I1A49_RS02570	COG0456	acetyltransferase
I1A49_RS02575	COG0300	oxidoreductase activity
I1A49_RS02590	COG1073	alpha beta
I1A49_RS02670	COG0583	DNA-binding transcription factor activity
I1A49_RS02675	COG5006	permease, DMT superfamily
I1A49_RS02680	COG1414	Transcriptional regulator
I1A49_RS02710	COG4106	trans-aconitate 2-methyltransferase activity
I1A49_RS02720	COG0492	ferredoxin-NADP+ reductase activity
I1A49_RS02725	COG0477	Major facilitator Superfamily
I1A49_RS02740	COG2197	response regulator
I1A49_RS02760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS02765	COG1609	Transcriptional regulator
I1A49_RS02770	COG2271	Major facilitator Superfamily
I1A49_RS02780	COG0277	FAD linked oxidase domain protein
I1A49_RS02785	COG2271	Major facilitator Superfamily
I1A49_RS02790	COG1609	Transcriptional regulator
I1A49_RS02800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1A49_RS02830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1A49_RS02835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A49_RS02840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I1A49_RS02855	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS02860	COG0477	Major facilitator Superfamily
I1A49_RS02865	COG3404	Formiminotransferase-cyclodeaminase
I1A49_RS02875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I1A49_RS02885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I1A49_RS02890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1A49_RS02910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I1A49_RS02915	COG2197	response regulator
I1A49_RS02920	COG4585	Histidine kinase
I1A49_RS02930	COG2197	response regulator
I1A49_RS02935	COG4585	Histidine kinase
I1A49_RS02960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A49_RS02970	COG4977	sequence-specific DNA binding
I1A49_RS02970	COG1917	Cupin 2, conserved barrel domain protein
I1A49_RS03005	COG1309	transcriptional regulator
I1A49_RS03010	COG0667	Aldo Keto reductase
I1A49_RS03020	COG2175	clavaminate synthase activity
I1A49_RS03025	COG4172	Belongs to the ABC transporter superfamily
I1A49_RS03035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS03040	COG0747	negative chemotaxis
I1A49_RS03050	COG3842	ATPase activity
I1A49_RS03055	COG1176	ABC-type spermidine putrescine transport system, permease component I
I1A49_RS03060	COG1177	transmembrane transport
I1A49_RS03075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS03080	COG1473	amidohydrolase
I1A49_RS03100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS03130	COG4172	Belongs to the ABC transporter superfamily
I1A49_RS03135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS03140	COG0601	transmembrane transport
I1A49_RS03145	COG0747	negative chemotaxis
I1A49_RS03150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS03155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS03160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS03175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS03200	COG1733	regulation of RNA biosynthetic process
I1A49_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS03210	COG4335	DNA alkylation repair
I1A49_RS03220	COG3246	L-lysine catabolic process to acetate
I1A49_RS03245	COG0477	Major facilitator Superfamily
I1A49_RS03255	COG3961	Belongs to the TPP enzyme family
I1A49_RS03275	COG3626	phosphonate metabolism
I1A49_RS03280	COG3627	carbon phosphorus lyase activity
I1A49_RS03285	COG4598	ABC transporter
I1A49_RS03290	COG3454	Phosphonate metabolism
I1A49_RS03330	COG0114	fumarate hydratase activity
I1A49_RS03340	COG0300	oxidoreductase activity
I1A49_RS03375	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A49_RS03385	COG2890	protein-(glutamine-N5) methyltransferase activity
I1A49_RS03390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I1A49_RS03420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1A49_RS03445	COG2192	nodulation
I1A49_RS03455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A49_RS03465	COG3321	synthase
I1A49_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS03465	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS03465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS03465	COG0300	oxidoreductase activity
I1A49_RS03480	COG4977	sequence-specific DNA binding
I1A49_RS03510	COG0753	catalase activity
I1A49_RS03515	COG1733	regulation of RNA biosynthetic process
I1A49_RS03525	COG2353	YceI-like domain
I1A49_RS03605	COG0583	DNA-binding transcription factor activity
I1A49_RS03615	COG2084	Dehydrogenase
I1A49_RS03620	COG3395	kinase activity
I1A49_RS03635	COG3622	Belongs to the hyi family
I1A49_RS03640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A49_RS03645	COG2186	Transcriptional regulator
I1A49_RS03655	COG2318	DinB family
I1A49_RS03660	COG0667	Aldo Keto reductase
I1A49_RS03710	COG1959	2 iron, 2 sulfur cluster binding
I1A49_RS03715	COG1017	nitric oxide dioxygenase activity
I1A49_RS03715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1A49_RS03720	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A49_RS03730	COG0789	Transcriptional regulator
I1A49_RS03740	COG0667	Aldo Keto reductase
I1A49_RS03775	COG0477	Major facilitator Superfamily
I1A49_RS03800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1A49_RS03810	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A49_RS03845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1A49_RS03875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I1A49_RS03915	COG2080	2 iron, 2 sulfur cluster binding
I1A49_RS03920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I1A49_RS03925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS03970	COG0328	RNA-DNA hybrid ribonuclease activity
I1A49_RS03975	COG2356	endonuclease I
I1A49_RS04050	COG3511	phospholipase C
I1A49_RS04080	COG1131	(ABC) transporter
I1A49_RS04090	COG0640	Transcriptional regulator
I1A49_RS04115	COG1357	PFAM Pentapeptide repeats (8 copies)
I1A49_RS04125	COG0306	phosphate transporter
I1A49_RS04140	COG0583	DNA-binding transcription factor activity
I1A49_RS04145	COG2175	clavaminate synthase activity
I1A49_RS04150	COG3629	intracellular signal transduction
I1A49_RS04150	COG3903	Transcriptional regulator
I1A49_RS04165	COG2267	carboxylic ester hydrolase activity
I1A49_RS04175	COG0114	fumarate hydratase activity
I1A49_RS04180	COG0726	polysaccharide deacetylase
I1A49_RS04195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1A49_RS04200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1A49_RS04205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS04215	COG3290	protein histidine kinase activity
I1A49_RS04220	COG4565	transcriptional regulatory protein
I1A49_RS04230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A49_RS04250	COG1309	transcriptional regulator
I1A49_RS04260	COG4221	oxidoreductase activity
I1A49_RS04265	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I1A49_RS04270	COG2376	Dihydroxyacetone kinase
I1A49_RS04275	COG2376	Dihydroxyacetone kinase
I1A49_RS04280	COG3594	Acyltransferase
I1A49_RS04340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS04350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS04355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I1A49_RS04360	COG2080	2 iron, 2 sulfur cluster binding
I1A49_RS04365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1A49_RS04405	COG0515	serine threonine protein kinase
I1A49_RS04405	COG2815	serine threonine protein kinase
I1A49_RS04435	COG0412	Dienelactone hydrolase
I1A49_RS04460	COG0326	Molecular chaperone. Has ATPase activity
I1A49_RS04485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I1A49_RS04495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A49_RS04510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A49_RS04520	COG2508	Transcriptional regulator
I1A49_RS04530	COG0739	heme binding
I1A49_RS04540	COG2175	clavaminate synthase activity
I1A49_RS04545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS04560	COG0142	geranyltranstransferase activity
I1A49_RS04565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A49_RS04585	COG2814	Major facilitator Superfamily
I1A49_RS04590	COG0668	transmembrane transport
I1A49_RS04595	COG2197	response regulator
I1A49_RS04625	COG3387	PFAM Glycoside hydrolase 15-related
I1A49_RS04635	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I1A49_RS04650	COG3537	Alpha-1,2-mannosidase
I1A49_RS04685	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS04690	COG2610	gluconate transmembrane transporter activity
I1A49_RS04715	COG1414	Transcriptional regulator
I1A49_RS04720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1A49_RS04730	COG1968	undecaprenyl-diphosphatase activity
I1A49_RS04735	COG1902	pentaerythritol trinitrate reductase activity
I1A49_RS04760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I1A49_RS04770	COG4221	oxidoreductase activity
I1A49_RS04850	COG3291	Pkd domain containing protein
I1A49_RS04850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I1A49_RS04875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1A49_RS04890	COG1064	alcohol dehydrogenase
I1A49_RS04900	COG2340	Cysteine-rich secretory protein family
I1A49_RS04910	COG0477	Major facilitator Superfamily
I1A49_RS04935	COG0435	Glutathione S-transferase
I1A49_RS04960	COG1472	Belongs to the glycosyl hydrolase 3 family
I1A49_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS04975	COG0701	Predicted permease
I1A49_RS04985	COG1819	glycosyl
I1A49_RS05010	COG0488	(ABC) transporter
I1A49_RS05025	COG0656	L-ascorbic acid biosynthetic process
I1A49_RS05035	COG3321	synthase
I1A49_RS05035	COG0604	alcohol dehydrogenase
I1A49_RS05050	COG0604	alcohol dehydrogenase
I1A49_RS05050	COG3321	synthase
I1A49_RS05090	COG0604	alcohol dehydrogenase
I1A49_RS05090	COG3321	synthase
I1A49_RS05100	COG0604	alcohol dehydrogenase
I1A49_RS05100	COG3321	synthase
I1A49_RS05125	COG0156	8-amino-7-oxononanoate synthase activity
I1A49_RS05135	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS05140	COG3509	depolymerase
I1A49_RS05155	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS05180	COG3835	regulator
I1A49_RS05185	COG2226	methyltransferase
I1A49_RS05195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I1A49_RS05205	COG2271	Major facilitator Superfamily
I1A49_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS05250	COG0129	dihydroxy-acid dehydratase activity
I1A49_RS05265	COG0701	Predicted permease
I1A49_RS05270	COG0673	inositol 2-dehydrogenase activity
I1A49_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS05315	COG0492	ferredoxin-NADP+ reductase activity
I1A49_RS05330	COG0475	glutathione-regulated potassium exporter activity
I1A49_RS05335	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS05375	COG1309	transcriptional regulator
I1A49_RS05385	COG2828	Protein conserved in bacteria
I1A49_RS05390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I1A49_RS05405	COG0531	amino acid
I1A49_RS05430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1A49_RS05455	COG3119	arylsulfatase activity
I1A49_RS05460	COG3507	Belongs to the glycosyl hydrolase 43 family
I1A49_RS05480	COG1175	transmembrane transport
I1A49_RS05485	COG0395	ABC-type sugar transport system, permease component
I1A49_RS05490	COG1609	Transcriptional regulator
I1A49_RS05500	COG0673	inositol 2-dehydrogenase activity
I1A49_RS05525	COG2197	response regulator
I1A49_RS05535	COG0577	efflux transmembrane transporter activity
I1A49_RS05540	COG1271	oxidase subunit
I1A49_RS05545	COG1294	oxidase, subunit
I1A49_RS05555	COG0515	serine threonine protein kinase
I1A49_RS05555	COG2815	serine threonine protein kinase
I1A49_RS05560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I1A49_RS05615	COG0431	NADPH-dependent FMN reductase
I1A49_RS05635	COG4977	sequence-specific DNA binding
I1A49_RS05640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A49_RS05675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I1A49_RS05685	COG3300	MHYT domain
I1A49_RS05685	COG5001	Diguanylate cyclase
I1A49_RS05715	COG0542	response to heat
I1A49_RS05725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I1A49_RS05725	COG0515	serine threonine protein kinase
I1A49_RS05760	COG0789	Transcriptional regulator
I1A49_RS05770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I1A49_RS05785	COG0546	phosphoglycolate phosphatase activity
I1A49_RS05815	COG3290	protein histidine kinase activity
I1A49_RS05825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I1A49_RS05850	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I1A49_RS05865	COG0604	alcohol dehydrogenase
I1A49_RS05865	COG3321	synthase
I1A49_RS05875	COG0604	alcohol dehydrogenase
I1A49_RS05875	COG3321	synthase
I1A49_RS05880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS05885	COG2197	response regulator
I1A49_RS05895	COG0778	Nitroreductase
I1A49_RS05900	COG1063	alcohol dehydrogenase
I1A49_RS05910	COG2072	flavoprotein involved in K transport
I1A49_RS05925	COG1053	succinate dehydrogenase
I1A49_RS05930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I1A49_RS05975	COG0583	DNA-binding transcription factor activity
I1A49_RS05985	COG0789	Transcriptional regulator
I1A49_RS06000	COG5006	permease, DMT superfamily
I1A49_RS06020	COG3467	pyridoxamine 5'-phosphate
I1A49_RS06055	COG0587	DNA-directed DNA polymerase activity
I1A49_RS06190	COG1175	transmembrane transport
I1A49_RS06195	COG0395	ABC-type sugar transport system, permease component
I1A49_RS06200	COG0366	Alpha amylase catalytic
I1A49_RS06210	COG0137	argininosuccinate synthase activity
I1A49_RS06220	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS06235	COG2353	YceI-like domain
I1A49_RS06250	COG0277	FAD linked oxidase domain protein
I1A49_RS06265	COG1136	(ABC) transporter
I1A49_RS06265	COG0577	efflux transmembrane transporter activity
I1A49_RS06270	COG1136	(ABC) transporter
I1A49_RS06270	COG0577	efflux transmembrane transporter activity
I1A49_RS06275	COG2197	response regulator
I1A49_RS06280	COG4585	Histidine kinase
I1A49_RS06300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS06305	COG0431	NADPH-dependent FMN reductase
I1A49_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS06420	COG1316	TRANSCRIPTIONal
I1A49_RS06425	COG2261	transglycosylase associated protein
I1A49_RS06435	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS06440	COG0477	Major facilitator Superfamily
I1A49_RS06445	COG1819	glycosyl
I1A49_RS06450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I1A49_RS06455	COG1309	transcriptional regulator
I1A49_RS06470	COG0583	DNA-binding transcription factor activity
I1A49_RS06485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I1A49_RS06525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I1A49_RS06535	COG0254	rRNA binding
I1A49_RS06540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1A49_RS06545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I1A49_RS06550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I1A49_RS06555	COG1024	Enoyl-CoA hydratase
I1A49_RS06605	COG1113	amino acid transport
I1A49_RS06610	COG2186	Transcriptional regulator
I1A49_RS06625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I1A49_RS06630	COG0673	inositol 2-dehydrogenase activity
I1A49_RS06645	COG2318	DinB family
I1A49_RS06650	COG2309	aminopeptidase activity
I1A49_RS06655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS06660	COG0477	Major facilitator Superfamily
I1A49_RS06685	COG1335	isochorismatase
I1A49_RS06690	COG0596	Alpha beta hydrolase
I1A49_RS06725	COG2378	regulation of single-species biofilm formation
I1A49_RS06735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I1A49_RS06760	COG0488	(ABC) transporter
I1A49_RS06780	COG0583	DNA-binding transcription factor activity
I1A49_RS06820	COG0384	phenazine biosynthesis protein PhzF
I1A49_RS06845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I1A49_RS06845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I1A49_RS06855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I1A49_RS06895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1A49_RS06925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1A49_RS06940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS06950	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I1A49_RS06955	COG1177	transmembrane transport
I1A49_RS06960	COG1176	ABC-type spermidine putrescine transport system, permease component I
I1A49_RS06965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I1A49_RS06970	COG3842	ATPase activity
I1A49_RS06985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1A49_RS06990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1A49_RS07005	COG2018	Roadblock/LC7 domain
I1A49_RS07025	COG2146	nitrite reductase [NAD(P)H] activity
I1A49_RS07045	COG4638	Rieske (2fe-2S)
I1A49_RS07050	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS07075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I1A49_RS07095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I1A49_RS07100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I1A49_RS07135	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS07230	COG2070	2-Nitropropane dioxygenase
I1A49_RS07240	COG0515	serine threonine protein kinase
I1A49_RS07240	COG2815	serine threonine protein kinase
I1A49_RS07265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I1A49_RS07270	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS07280	COG2376	Dihydroxyacetone kinase
I1A49_RS07285	COG1461	Dihydroxyacetone kinase
I1A49_RS07290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A49_RS07290	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I1A49_RS07290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1A49_RS07295	COG0142	geranyltranstransferase activity
I1A49_RS07305	COG2124	cytochrome p450
I1A49_RS07310	COG2124	cytochrome p450
I1A49_RS07335	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS07340	COG0494	nUDIX hydrolase
I1A49_RS07355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I1A49_RS07415	COG1349	DNA-binding transcription factor activity
I1A49_RS07450	COG1940	carbohydrate kinase activity
I1A49_RS07480	COG2197	response regulator
I1A49_RS07485	COG4585	Histidine kinase
I1A49_RS07490	COG0445	tRNA wobble uridine modification
I1A49_RS07500	COG1660	Displays ATPase and GTPase activities
I1A49_RS07505	COG0395	ABC-type sugar transport system, permease component
I1A49_RS07510	COG1175	transmembrane transport
I1A49_RS07520	COG3345	alpha-galactosidase
I1A49_RS07570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I1A49_RS07610	COG0584	glycerophosphoryl diester phosphodiesterase
I1A49_RS07640	COG0671	phosphoesterase, PA-phosphatase related
I1A49_RS07645	COG2271	Major facilitator Superfamily
I1A49_RS07650	COG1846	Transcriptional regulator
I1A49_RS07655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A49_RS07660	COG1024	Enoyl-CoA hydratase
I1A49_RS07670	COG1024	Enoyl-CoA hydratase
I1A49_RS07675	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS07680	COG2070	2-Nitropropane dioxygenase
I1A49_RS07720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I1A49_RS07725	COG0601	transmembrane transport
I1A49_RS07730	COG4166	transmembrane transport
I1A49_RS07750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A49_RS07765	COG0596	Alpha beta hydrolase
I1A49_RS07770	COG0604	alcohol dehydrogenase
I1A49_RS07770	COG3321	synthase
I1A49_RS07775	COG3321	synthase
I1A49_RS07775	COG0604	alcohol dehydrogenase
I1A49_RS07785	COG0604	alcohol dehydrogenase
I1A49_RS07785	COG3321	synthase
I1A49_RS07815	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS07825	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS07865	COG1309	transcriptional regulator
I1A49_RS07885	COG2233	PERMEase
I1A49_RS07890	COG0640	Transcriptional regulator
I1A49_RS07895	COG1902	pentaerythritol trinitrate reductase activity
I1A49_RS07905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I1A49_RS07925	COG2706	6-phosphogluconolactonase activity
I1A49_RS07945	COG2027	D-alanyl-D-alanine carboxypeptidase
I1A49_RS07955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS08010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS08015	COG3119	arylsulfatase activity
I1A49_RS08030	COG3639	organic phosphonate transmembrane transporter activity
I1A49_RS08040	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I1A49_RS08070	COG3850	Histidine kinase
I1A49_RS08080	COG1131	(ABC) transporter
I1A49_RS08085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I1A49_RS08095	COG2188	Transcriptional regulator
I1A49_RS08100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A49_RS08105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A49_RS08140	COG1414	Transcriptional regulator
I1A49_RS08150	COG1175	transmembrane transport
I1A49_RS08155	COG0395	ABC-type sugar transport system, permease component
I1A49_RS08160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I1A49_RS08180	COG2226	methyltransferase
I1A49_RS08195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I1A49_RS08220	COG1902	pentaerythritol trinitrate reductase activity
I1A49_RS08235	COG0656	L-ascorbic acid biosynthetic process
I1A49_RS08245	COG2814	Major facilitator Superfamily
I1A49_RS08255	COG0583	DNA-binding transcription factor activity
I1A49_RS08275	COG1231	oxidoreductase activity
I1A49_RS08280	COG3961	Belongs to the TPP enzyme family
I1A49_RS08295	COG0251	oxidation-reduction process
I1A49_RS08310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS08320	COG0596	Alpha beta hydrolase
I1A49_RS08330	COG2267	carboxylic ester hydrolase activity
I1A49_RS08360	COG0243	molybdopterin cofactor binding
I1A49_RS08365	COG1120	ATPase activity
I1A49_RS08370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS08380	COG1595	DNA-templated transcription, initiation
I1A49_RS08385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A49_RS08405	COG0515	serine threonine protein kinase
I1A49_RS08425	COG3971	2-oxopent-4-enoate hydratase activity
I1A49_RS08445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS08450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS08460	COG1116	anion transmembrane transporter activity
I1A49_RS08465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS08480	COG0745	RESPONSE REGULATOR receiver
I1A49_RS08485	COG2205	protein histidine kinase activity
I1A49_RS08495	COG1309	transcriptional regulator
I1A49_RS08510	COG1309	transcriptional regulator
I1A49_RS08520	COG0277	FAD linked oxidase domain protein
I1A49_RS08555	COG2197	response regulator
I1A49_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS08615	COG1802	Transcriptional regulator
I1A49_RS08620	COG1129	ABC transporter
I1A49_RS08635	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS08645	COG3469	chitinase activity
I1A49_RS08680	COG3469	chitinase activity
I1A49_RS08715	COG0395	ABC-type sugar transport system, permease component
I1A49_RS08720	COG4209	transmembrane transport
I1A49_RS08725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1A49_RS08735	COG0673	inositol 2-dehydrogenase activity
I1A49_RS08800	COG0698	ribose 5-phosphate isomerase
I1A49_RS08805	COG2376	Dihydroxyacetone kinase
I1A49_RS08810	COG1070	Carbohydrate kinase
I1A49_RS08820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A49_RS08825	COG1349	DNA-binding transcription factor activity
I1A49_RS08830	COG2814	Major facilitator Superfamily
I1A49_RS08840	COG1349	DNA-binding transcription factor activity
I1A49_RS08845	COG1070	Carbohydrate kinase
I1A49_RS08850	COG1070	Carbohydrate kinase
I1A49_RS08855	COG0588	phosphoglycerate mutase activity
I1A49_RS08865	COG3795	YCII-related domain
I1A49_RS08870	COG4941	Belongs to the sigma-70 factor family
I1A49_RS08885	COG0300	oxidoreductase activity
I1A49_RS08985	COG0436	Aminotransferase
I1A49_RS08990	COG1802	Transcriptional regulator
I1A49_RS08995	COG1309	transcriptional regulator
I1A49_RS09000	COG0154	amidase activity
I1A49_RS09025	COG1968	undecaprenyl-diphosphatase activity
I1A49_RS09030	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS09050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I1A49_RS09055	COG1917	Cupin 2, conserved barrel domain protein
I1A49_RS09055	COG4977	sequence-specific DNA binding
I1A49_RS09060	COG0583	DNA-binding transcription factor activity
I1A49_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS09080	COG0583	DNA-binding transcription factor activity
I1A49_RS09105	COG2072	flavoprotein involved in K transport
I1A49_RS09115	COG0596	Alpha beta hydrolase
I1A49_RS09140	COG1233	COG1233 Phytoene dehydrogenase and related
I1A49_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS09200	COG3850	Histidine kinase
I1A49_RS09205	COG2197	response regulator
I1A49_RS09240	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS09245	COG0583	DNA-binding transcription factor activity
I1A49_RS09265	COG2824	Alkylphosphonate utilization operon protein PhnA
I1A49_RS09305	COG0583	DNA-binding transcription factor activity
I1A49_RS09310	COG1309	transcriptional regulator
I1A49_RS09320	COG0702	epimerase
I1A49_RS09340	COG0402	S-adenosylhomocysteine deaminase activity
I1A49_RS09360	COG2124	cytochrome p450
I1A49_RS09370	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS09385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A49_RS09390	COG1937	Protein conserved in bacteria
I1A49_RS09430	COG0745	RESPONSE REGULATOR receiver
I1A49_RS09440	COG3180	Ammonia monooxygenase
I1A49_RS09445	COG0745	RESPONSE REGULATOR receiver
I1A49_RS09450	COG2205	protein histidine kinase activity
I1A49_RS09465	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS09475	COG1175	transmembrane transport
I1A49_RS09485	COG2188	Transcriptional regulator
I1A49_RS09495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A49_RS09500	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS09510	COG1064	alcohol dehydrogenase
I1A49_RS09515	COG1309	transcriptional regulator
I1A49_RS09525	COG4221	oxidoreductase activity
I1A49_RS09535	COG3458	cephalosporin-C deacetylase activity
I1A49_RS09540	COG0346	lactoylglutathione lyase activity
I1A49_RS09560	COG0145	ligase activity
I1A49_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS09610	COG2814	Major facilitator Superfamily
I1A49_RS09625	COG4585	Histidine kinase
I1A49_RS09630	COG2409	Drug exporters of the RND superfamily
I1A49_RS09635	COG1131	(ABC) transporter
I1A49_RS09635	COG1716	ATPase activity
I1A49_RS09635	COG0842	Transport permease protein
I1A49_RS09670	COG1120	ATPase activity
I1A49_RS09675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS09685	COG4221	oxidoreductase activity
I1A49_RS09695	COG0069	glutamate synthase activity
I1A49_RS09715	COG0640	Transcriptional regulator
I1A49_RS09720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1A49_RS09730	COG1316	TRANSCRIPTIONal
I1A49_RS09735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1A49_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS09770	COG1396	sequence-specific DNA binding
I1A49_RS09780	COG2318	DinB family
I1A49_RS09790	COG1082	Xylose isomerase domain protein TIM barrel
I1A49_RS09795	COG0300	oxidoreductase activity
I1A49_RS09820	COG0477	Major facilitator Superfamily
I1A49_RS09845	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS09855	COG0477	Major facilitator Superfamily
I1A49_RS09870	COG0604	alcohol dehydrogenase
I1A49_RS09870	COG3321	synthase
I1A49_RS09880	COG0604	alcohol dehydrogenase
I1A49_RS09880	COG3321	synthase
I1A49_RS09890	COG2197	response regulator
I1A49_RS09900	COG0702	epimerase
I1A49_RS09905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS09930	COG1408	metallophosphoesterase
I1A49_RS09950	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I1A49_RS09975	COG4770	biotin carboxylase activity
I1A49_RS09980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A49_RS09985	COG2807	transmembrane transport
I1A49_RS10000	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS10015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A49_RS10025	COG1309	transcriptional regulator
I1A49_RS10040	COG1024	Enoyl-CoA hydratase
I1A49_RS10045	COG1024	Enoyl-CoA hydratase
I1A49_RS10050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A49_RS10055	COG1022	Amp-dependent synthetase and ligase
I1A49_RS10085	COG1309	transcriptional regulator
I1A49_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS10095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS10105	COG0667	Aldo Keto reductase
I1A49_RS10120	COG1620	l-lactate permease
I1A49_RS10125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS10125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS10140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS10145	COG2186	Transcriptional regulator
I1A49_RS10155	COG0583	DNA-binding transcription factor activity
I1A49_RS10185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1A49_RS10200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I1A49_RS10215	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS10225	COG0546	phosphoglycolate phosphatase activity
I1A49_RS10240	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I1A49_RS10255	COG3321	synthase
I1A49_RS10255	COG0604	alcohol dehydrogenase
I1A49_RS10335	COG0604	alcohol dehydrogenase
I1A49_RS10345	COG0531	amino acid
I1A49_RS10370	COG1063	alcohol dehydrogenase
I1A49_RS10395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I1A49_RS10405	COG0277	FAD linked oxidase domain protein
I1A49_RS10415	COG0028	Belongs to the TPP enzyme family
I1A49_RS10430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I1A49_RS10445	COG1472	Belongs to the glycosyl hydrolase 3 family
I1A49_RS10560	COG3959	Transketolase, thiamine diphosphate binding domain
I1A49_RS10565	COG3958	Transketolase
I1A49_RS10570	COG2267	carboxylic ester hydrolase activity
I1A49_RS10575	COG1228	amidohydrolase
I1A49_RS10590	COG1309	transcriptional regulator
I1A49_RS10610	COG4175	Glycine betaine
I1A49_RS10610	COG0517	IMP dehydrogenase activity
I1A49_RS10615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A49_RS10640	COG0805	protein transport
I1A49_RS10645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1A49_RS10665	COG2378	regulation of single-species biofilm formation
I1A49_RS10675	COG0545	Peptidyl-prolyl cis-trans isomerase
I1A49_RS10680	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I1A49_RS10690	COG1609	Transcriptional regulator
I1A49_RS10695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I1A49_RS10700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I1A49_RS10710	COG4122	O-methyltransferase activity
I1A49_RS10715	COG1222	aaa ATPase
I1A49_RS10735	COG1994	Peptidase M50
I1A49_RS10735	COG0517	IMP dehydrogenase activity
I1A49_RS10745	COG2197	response regulator
I1A49_RS10755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A49_RS10760	COG0646	methionine synthase
I1A49_RS10760	COG1410	methionine synthase
I1A49_RS10765	COG1414	Transcriptional regulator
I1A49_RS10770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1A49_RS10775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1A49_RS10780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I1A49_RS10795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS10805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS10815	COG2186	Transcriptional regulator
I1A49_RS10830	COG4211	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS10835	COG1129	ABC transporter
I1A49_RS10845	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS10850	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS10860	COG0215	cysteine-tRNA ligase activity
I1A49_RS10880	COG0598	Magnesium transport protein CorA
I1A49_RS10890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS10895	COG0667	Aldo Keto reductase
I1A49_RS10945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I1A49_RS10950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I1A49_RS10955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I1A49_RS10980	COG4221	oxidoreductase activity
I1A49_RS11000	COG0297	glycogen (starch) synthase activity
I1A49_RS11020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A49_RS11025	COG2080	2 iron, 2 sulfur cluster binding
I1A49_RS11030	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I1A49_RS11035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS11055	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS11110	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I1A49_RS11115	COG2149	membrane
I1A49_RS11135	COG1733	regulation of RNA biosynthetic process
I1A49_RS11155	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS11200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I1A49_RS11205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I1A49_RS11210	COG0142	geranyltranstransferase activity
I1A49_RS11215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I1A49_RS11220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I1A49_RS11235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS11250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I1A49_RS11255	COG2409	Drug exporters of the RND superfamily
I1A49_RS11280	COG2851	Citrate transporter
I1A49_RS11285	COG0243	molybdopterin cofactor binding
I1A49_RS11290	COG1309	transcriptional regulator
I1A49_RS11295	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I1A49_RS11300	COG2188	Transcriptional regulator
I1A49_RS11330	COG0515	serine threonine protein kinase
I1A49_RS11335	COG2755	lipolytic protein G-D-S-L family
I1A49_RS11350	COG0463	Glycosyl transferase, family 2
I1A49_RS11360	COG0726	polysaccharide deacetylase
I1A49_RS11360	COG1649	PFAM Uncharacterised BCR, COG1649
I1A49_RS11380	COG1834	amidinotransferase
I1A49_RS11405	COG2226	methyltransferase
I1A49_RS11405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I1A49_RS11405	COG0596	Alpha beta hydrolase
I1A49_RS11410	COG2124	cytochrome p450
I1A49_RS11445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I1A49_RS11445	COG0519	Catalyzes the synthesis of GMP from XMP
I1A49_RS11475	COG0019	diaminopimelate decarboxylase activity
I1A49_RS11510	COG1846	Transcriptional regulator
I1A49_RS11515	COG1764	response to oxidative stress
I1A49_RS11525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I1A49_RS11535	COG3467	pyridoxamine 5'-phosphate
I1A49_RS11560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS11565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A49_RS11570	COG1126	abc transporter atp-binding protein
I1A49_RS11590	COG1799	cell septum assembly
I1A49_RS11595	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS11660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1A49_RS11675	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS11690	COG1160	GTP binding
I1A49_RS11700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I1A49_RS11715	COG1187	pseudouridine synthase activity
I1A49_RS11720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I1A49_RS11725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I1A49_RS11740	COG0686	Belongs to the AlaDH PNT family
I1A49_RS11745	COG3629	intracellular signal transduction
I1A49_RS11745	COG3903	Transcriptional regulator
I1A49_RS11750	COG0494	nUDIX hydrolase
I1A49_RS11755	COG0504	CTP synthase activity
I1A49_RS11760	COG3387	PFAM Glycoside hydrolase 15-related
I1A49_RS11775	COG0297	glycogen (starch) synthase activity
I1A49_RS11780	COG0497	DNA recombination
I1A49_RS11785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1A49_RS11805	COG1120	ATPase activity
I1A49_RS11810	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS11815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS11820	COG0647	UMP catabolic process
I1A49_RS11855	COG2094	Belongs to the DNA glycosylase MPG family
I1A49_RS11870	COG1881	PFAM PEBP family protein
I1A49_RS11890	COG1119	ATPase activity
I1A49_RS11905	COG2197	response regulator
I1A49_RS11915	COG3953	SLT domain
I1A49_RS11915	COG5280	Phage tail tape measure protein TP901
I1A49_RS11920	COG1131	(ABC) transporter
I1A49_RS11920	COG0842	Transport permease protein
I1A49_RS11920	COG1716	ATPase activity
I1A49_RS11930	COG3830	Belongs to the UPF0237 family
I1A49_RS11930	COG0560	Phosphoserine phosphatase
I1A49_RS11945	COG2807	transmembrane transport
I1A49_RS11950	COG2186	Transcriptional regulator
I1A49_RS11960	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I1A49_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS11970	COG1902	pentaerythritol trinitrate reductase activity
I1A49_RS12015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I1A49_RS12035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I1A49_RS12040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A49_RS12075	COG2176	DNA-directed DNA polymerase activity
I1A49_RS12090	COG3387	PFAM Glycoside hydrolase 15-related
I1A49_RS12095	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS12135	COG4999	Histidine kinase
I1A49_RS12135	COG3437	response regulator, receiver
I1A49_RS12135	COG3850	Histidine kinase
I1A49_RS12135	COG2205	protein histidine kinase activity
I1A49_RS12155	COG0488	(ABC) transporter
I1A49_RS12170	COG0235	Class ii aldolase
I1A49_RS12185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I1A49_RS12190	COG1492	cobalamin metabolic process
I1A49_RS12245	COG0456	acetyltransferase
I1A49_RS12255	COG1917	Cupin 2, conserved barrel domain protein
I1A49_RS12260	COG5285	phytanoyl-CoA dioxygenase
I1A49_RS12265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1A49_RS12275	COG1414	Transcriptional regulator
I1A49_RS12295	COG0667	Aldo Keto reductase
I1A49_RS12300	COG2252	PERMEase
I1A49_RS12330	COG0395	ABC-type sugar transport system, permease component
I1A49_RS12345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS12350	COG1802	Transcriptional regulator
I1A49_RS12365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS12370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A49_RS12375	COG1335	isochorismatase
I1A49_RS12380	COG0477	Major facilitator Superfamily
I1A49_RS12400	COG1090	epimerase
I1A49_RS12435	COG2171	N-acyltransferase activity
I1A49_RS12440	COG3226	Transcriptional regulator
I1A49_RS12445	COG2076	Multidrug Resistance protein
I1A49_RS12450	COG2151	metal-sulfur cluster biosynthetic enzyme
I1A49_RS12455	COG0822	iron-sulfur transferase activity
I1A49_RS12460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1A49_RS12465	COG0396	ATPase activity
I1A49_RS12475	COG0719	Fe-S assembly protein
I1A49_RS12500	COG1612	heme a metabolic process
I1A49_RS12515	COG0109	protoheme IX farnesyltransferase activity
I1A49_RS12520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1A49_RS12525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I1A49_RS12540	COG0363	glucosamine-6-phosphate deaminase activity
I1A49_RS12545	COG0166	Belongs to the GPI family
I1A49_RS12560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I1A49_RS12565	COG0149	triose-phosphate isomerase activity
I1A49_RS12570	COG0126	phosphoglycerate kinase activity
I1A49_RS12575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1A49_RS12585	COG1481	regulation of sporulation
I1A49_RS12590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I1A49_RS12595	COG1660	Displays ATPase and GTPase activities
I1A49_RS12600	COG0322	excinuclease ABC activity
I1A49_RS12610	COG1609	Transcriptional regulator
I1A49_RS12620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I1A49_RS12635	COG0477	Major facilitator Superfamily
I1A49_RS12655	COG0556	nucleotide-excision repair
I1A49_RS12660	COG0584	glycerophosphoryl diester phosphodiesterase
I1A49_RS12665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I1A49_RS12715	COG0237	dephospho-CoA kinase activity
I1A49_RS12740	COG1643	Atp-dependent helicase
I1A49_RS12785	COG2050	protein possibly involved in aromatic compounds catabolism
I1A49_RS12810	COG0411	ABC transporter
I1A49_RS12845	COG0494	nUDIX hydrolase
I1A49_RS12850	COG0737	Belongs to the 5'-nucleotidase family
I1A49_RS12875	COG1605	Chorismate mutase
I1A49_RS12875	COG0287	Prephenate dehydrogenase
I1A49_RS12895	COG3467	pyridoxamine 5'-phosphate
I1A49_RS12910	COG1131	(ABC) transporter
I1A49_RS12915	COG1725	Transcriptional regulator
I1A49_RS12925	COG0067	glutamate synthase
I1A49_RS12925	COG0069	glutamate synthase activity
I1A49_RS12925	COG0070	glutamate synthase
I1A49_RS12935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I1A49_RS12945	COG0159	tryptophan synthase activity
I1A49_RS12950	COG0133	tryptophan synthase activity
I1A49_RS12955	COG0134	indole-3-glycerol-phosphate synthase activity
I1A49_RS12975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1A49_RS12980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I1A49_RS13015	COG1120	ATPase activity
I1A49_RS13030	COG4221	oxidoreductase activity
I1A49_RS13035	COG0107	imidazoleglycerol-phosphate synthase activity
I1A49_RS13040	COG0251	oxidation-reduction process
I1A49_RS13045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I1A49_RS13050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I1A49_RS13060	COG0131	Imidazoleglycerol-phosphate dehydratase
I1A49_RS13065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A49_RS13070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I1A49_RS13080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I1A49_RS13085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I1A49_RS13115	COG0587	DNA-directed DNA polymerase activity
I1A49_RS13160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I1A49_RS13170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I1A49_RS13185	COG1799	cell septum assembly
I1A49_RS13195	COG1496	oxidoreductase activity
I1A49_RS13200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I1A49_RS13205	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I1A49_RS13210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1A49_RS13220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I1A49_RS13225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1A49_RS13235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I1A49_RS13255	COG0275	rRNA processing
I1A49_RS13265	COG0714	Associated with various cellular activities
I1A49_RS13295	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I1A49_RS13305	COG1309	transcriptional regulator
I1A49_RS13310	COG1233	COG1233 Phytoene dehydrogenase and related
I1A49_RS13325	COG0352	thiamine-phosphate diphosphorylase activity
I1A49_RS13340	COG2022	thiamine diphosphate biosynthetic process
I1A49_RS13340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A49_RS13350	COG2022	thiamine diphosphate biosynthetic process
I1A49_RS13370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I1A49_RS13380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I1A49_RS13385	COG2193	ferroxidase activity
I1A49_RS13390	COG0243	molybdopterin cofactor binding
I1A49_RS13395	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I1A49_RS13410	COG0205	6-phosphofructokinase activity
I1A49_RS13445	COG1940	carbohydrate kinase activity
I1A49_RS13515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1A49_RS13520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1A49_RS13525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1A49_RS13530	COG0723	plastoquinol--plastocyanin reductase activity
I1A49_RS13535	COG2010	Cytochrome c
I1A49_RS13540	COG1845	cytochrome c oxidase, subunit III
I1A49_RS13550	COG1376	ErfK ybiS ycfS ynhG family protein
I1A49_RS13560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1A49_RS13565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I1A49_RS13575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS13595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I1A49_RS13600	COG2197	response regulator
I1A49_RS13605	COG4585	Histidine kinase
I1A49_RS13640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I1A49_RS13645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I1A49_RS13650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I1A49_RS13655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A49_RS13670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I1A49_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS13705	COG0640	Transcriptional regulator
I1A49_RS13715	COG0321	lipoyl(octanoyl) transferase activity
I1A49_RS13720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1A49_RS13740	COG0174	glutamine synthetase
I1A49_RS13760	COG1280	lysine exporter protein (LysE YggA)
I1A49_RS13770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I1A49_RS13800	COG0477	Major facilitator Superfamily
I1A49_RS13815	COG0745	RESPONSE REGULATOR receiver
I1A49_RS13835	COG2197	response regulator
I1A49_RS13865	COG3833	ABC-type maltose transport systems, permease component
I1A49_RS13875	COG2182	Extracellular solute-binding protein
I1A49_RS13880	COG0366	Alpha amylase catalytic
I1A49_RS13885	COG1609	Transcriptional regulator
I1A49_RS13895	COG0561	phosphatase activity
I1A49_RS13900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1A49_RS13910	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I1A49_RS13935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I1A49_RS13940	COG0174	glutamine synthetase
I1A49_RS13950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I1A49_RS13950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A49_RS13955	COG2267	carboxylic ester hydrolase activity
I1A49_RS13960	COG2814	Major facilitator Superfamily
I1A49_RS13970	COG1309	transcriptional regulator
I1A49_RS13975	COG0477	Major facilitator Superfamily
I1A49_RS13980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I1A49_RS14005	COG1994	Peptidase M50
I1A49_RS14020	COG0395	ABC-type sugar transport system, permease component
I1A49_RS14025	COG1175	transmembrane transport
I1A49_RS14095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A49_RS14100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS14110	COG2822	iron ion transport
I1A49_RS14115	COG2837	iron assimilation
I1A49_RS14120	COG0672	)-iron permease
I1A49_RS14145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I1A49_RS14155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I1A49_RS14160	COG2814	Major facilitator Superfamily
I1A49_RS14170	COG3540	Alkaline phosphatase
I1A49_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS14215	COG0443	Heat shock 70 kDa protein
I1A49_RS14220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I1A49_RS14235	COG0542	response to heat
I1A49_RS14265	COG0596	Alpha beta hydrolase
I1A49_RS14270	COG0583	DNA-binding transcription factor activity
I1A49_RS14275	COG0473	3-isopropylmalate dehydrogenase activity
I1A49_RS14295	COG2197	response regulator
I1A49_RS14305	COG2409	Drug exporters of the RND superfamily
I1A49_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS14330	COG0798	PFAM Bile acid sodium symporter
I1A49_RS14335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1A49_RS14345	COG3022	response to hydroperoxide
I1A49_RS14350	COG0800	Aldolase
I1A49_RS14365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I1A49_RS14385	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS14390	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I1A49_RS14395	COG2030	dehydratase
I1A49_RS14415	COG3510	cephalosporin hydroxylase
I1A49_RS14420	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1A49_RS14430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS14450	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS14455	COG1309	transcriptional regulator
I1A49_RS14460	COG2197	response regulator
I1A49_RS14505	COG3845	ABC transporter
I1A49_RS14520	COG0183	Belongs to the thiolase family
I1A49_RS14525	COG2124	cytochrome p450
I1A49_RS14545	COG2207	Transcriptional regulator
I1A49_RS14560	COG0604	alcohol dehydrogenase
I1A49_RS14580	COG5002	protein histidine kinase activity
I1A49_RS14610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1A49_RS14640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A49_RS14705	COG0740	serine-type endopeptidase activity
I1A49_RS14710	COG0740	serine-type endopeptidase activity
I1A49_RS14745	COG1309	transcriptional regulator
I1A49_RS14765	COG3629	intracellular signal transduction
I1A49_RS14765	COG3903	Transcriptional regulator
I1A49_RS14770	COG4106	trans-aconitate 2-methyltransferase activity
I1A49_RS14775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1A49_RS14785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A49_RS14820	COG0604	alcohol dehydrogenase
I1A49_RS14895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I1A49_RS14905	COG0477	Major facilitator Superfamily
I1A49_RS14910	COG1309	transcriptional regulator
I1A49_RS14925	COG4585	Histidine kinase
I1A49_RS14930	COG2197	response regulator
I1A49_RS14940	COG0667	Aldo Keto reductase
I1A49_RS14945	COG0789	Transcriptional regulator
I1A49_RS14970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1A49_RS14975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS14980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS14985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I1A49_RS15025	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS15045	COG1129	ABC transporter
I1A49_RS15050	COG4214	carbohydrate transport
I1A49_RS15085	COG2130	NADP-dependent
I1A49_RS15100	COG3386	PFAM SMP-30 Gluconolaconase
I1A49_RS15105	COG1414	Transcriptional regulator
I1A49_RS15120	COG0588	phosphoglycerate mutase activity
I1A49_RS15125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A49_RS15160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS15165	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I1A49_RS15170	COG2080	2 iron, 2 sulfur cluster binding
I1A49_RS15175	COG2207	Transcriptional regulator
I1A49_RS15180	COG1486	melibiose metabolic process
I1A49_RS15200	COG1175	transmembrane transport
I1A49_RS15205	COG0395	ABC-type sugar transport system, permease component
I1A49_RS15210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1A49_RS15220	COG2197	response regulator
I1A49_RS15225	COG3851	Histidine kinase
I1A49_RS15255	COG2070	2-Nitropropane dioxygenase
I1A49_RS15305	COG0776	regulation of translation
I1A49_RS15440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I1A49_RS15585	COG1518	maintenance of DNA repeat elements
I1A49_RS15590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I1A49_RS15600	COG1475	DNA binding
I1A49_RS15660	COG1070	Carbohydrate kinase
I1A49_RS15665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1A49_RS15670	COG0358	DNA primase activity
I1A49_RS15680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I1A49_RS15690	COG0243	molybdopterin cofactor binding
I1A49_RS15695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I1A49_RS15730	COG0745	RESPONSE REGULATOR receiver
I1A49_RS15735	COG2205	protein histidine kinase activity
I1A49_RS15760	COG2124	cytochrome p450
I1A49_RS15765	COG2124	cytochrome p450
I1A49_RS15770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A49_RS15775	COG2146	nitrite reductase [NAD(P)H] activity
I1A49_RS15775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A49_RS15785	COG1609	Transcriptional regulator
I1A49_RS15795	COG1175	transmembrane transport
I1A49_RS15805	COG1472	Belongs to the glycosyl hydrolase 3 family
I1A49_RS15815	COG0300	oxidoreductase activity
I1A49_RS15820	COG2890	protein-(glutamine-N5) methyltransferase activity
I1A49_RS15825	COG1846	Transcriptional regulator
I1A49_RS15830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I1A49_RS15835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I1A49_RS15840	COG0183	Belongs to the thiolase family
I1A49_RS15845	COG3485	protocatechuate 3,4-dioxygenase
I1A49_RS15850	COG3485	protocatechuate 3,4-dioxygenase
I1A49_RS15855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I1A49_RS15865	COG2182	Extracellular solute-binding protein
I1A49_RS15870	COG1175	transmembrane transport
I1A49_RS15875	COG0395	ABC-type sugar transport system, permease component
I1A49_RS15880	COG2188	Transcriptional regulator
I1A49_RS15885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1A49_RS15890	COG0531	amino acid
I1A49_RS15905	COG0745	RESPONSE REGULATOR receiver
I1A49_RS15930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1A49_RS15930	COG0574	Belongs to the PEP-utilizing enzyme family
I1A49_RS15935	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I1A49_RS15975	COG0477	Major facilitator Superfamily
I1A49_RS15980	COG2197	response regulator
I1A49_RS16000	COG0423	glycine-tRNA ligase activity
I1A49_RS16010	COG1121	(ABC) transporter
I1A49_RS16015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1A49_RS16050	COG0596	Alpha beta hydrolase
I1A49_RS16080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1A49_RS16085	COG1381	Involved in DNA repair and RecF pathway recombination
I1A49_RS16110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I1A49_RS16160	COG3422	double-strand break repair
I1A49_RS16165	COG2197	response regulator
I1A49_RS16170	COG4585	Histidine kinase
I1A49_RS16175	COG2409	Drug exporters of the RND superfamily
I1A49_RS16185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A49_RS16200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I1A49_RS16220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I1A49_RS16230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS16235	COG1234	tRNA 3'-trailer cleavage
I1A49_RS16240	COG0537	adenosine 5'-monophosphoramidase activity
I1A49_RS16260	COG0484	heat shock protein binding
I1A49_RS16265	COG1420	regulation of RNA biosynthetic process
I1A49_RS16290	COG1022	Amp-dependent synthetase and ligase
I1A49_RS16295	COG0481	GTPase activity
I1A49_RS16300	COG0268	Binds directly to 16S ribosomal RNA
I1A49_RS16395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A49_RS16395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A49_RS16485	COG0270	DNA (cytosine-5-)-methyltransferase activity
I1A49_RS16590	COG0237	dephospho-CoA kinase activity
I1A49_RS16755	COG1555	photosystem II stabilization
I1A49_RS16760	COG1307	EDD domain protein, DegV family
I1A49_RS16770	COG0495	leucyl-tRNA aminoacylation
I1A49_RS16795	COG0406	alpha-ribazole phosphatase activity
I1A49_RS16800	COG0799	negative regulation of ribosome biogenesis
I1A49_RS16810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I1A49_RS16825	COG0501	Belongs to the peptidase M48B family
I1A49_RS16840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1A49_RS16850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I1A49_RS16860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I1A49_RS16865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I1A49_RS16870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I1A49_RS16895	COG0772	Belongs to the SEDS family
I1A49_RS16900	COG0768	penicillin binding
I1A49_RS16915	COG1077	Cell shape determining protein MreB Mrl
I1A49_RS16920	COG0105	UTP biosynthetic process
I1A49_RS16930	COG0285	dihydrofolate synthase activity
I1A49_RS16935	COG0768	penicillin binding
I1A49_RS16940	COG0525	valine-tRNA ligase activity
I1A49_RS16960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I1A49_RS16965	COG0740	serine-type endopeptidase activity
I1A49_RS16970	COG0740	serine-type endopeptidase activity
I1A49_RS16975	COG0544	peptidyl-prolyl cis-trans isomerase activity
I1A49_RS16995	COG3594	Acyltransferase
I1A49_RS17015	COG4552	Acetyltransferase involved in intracellular survival and related
I1A49_RS17025	COG0698	ribose 5-phosphate isomerase
I1A49_RS17030	COG1113	amino acid transport
I1A49_RS17060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I1A49_RS17090	COG0235	Class ii aldolase
I1A49_RS17095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1A49_RS17110	COG1113	amino acid transport
I1A49_RS17120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I1A49_RS17180	COG3291	Pkd domain containing protein
I1A49_RS17180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I1A49_RS17190	COG0668	transmembrane transport
I1A49_RS17200	COG1940	carbohydrate kinase activity
I1A49_RS17200	COG1846	Transcriptional regulator
I1A49_RS17205	COG1653	transport
I1A49_RS17210	COG1175	transmembrane transport
I1A49_RS17220	COG1486	melibiose metabolic process
I1A49_RS17235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A49_RS17265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I1A49_RS17295	COG0629	single-stranded DNA binding
I1A49_RS17320	COG1309	transcriptional regulator
I1A49_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS17355	COG0346	lactoylglutathione lyase activity
I1A49_RS17365	COG3251	PFAM MbtH domain protein
I1A49_RS17370	COG0142	geranyltranstransferase activity
I1A49_RS17375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I1A49_RS17380	COG1993	acr, cog1993
I1A49_RS17385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I1A49_RS17390	COG0583	DNA-binding transcription factor activity
I1A49_RS17410	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS17420	COG1131	(ABC) transporter
I1A49_RS17445	COG1309	transcriptional regulator
I1A49_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS17455	COG1215	transferase activity, transferring glycosyl groups
I1A49_RS17505	COG3321	synthase
I1A49_RS17505	COG0604	alcohol dehydrogenase
I1A49_RS17540	COG0604	alcohol dehydrogenase
I1A49_RS17540	COG3321	synthase
I1A49_RS17555	COG3402	PFAM membrane-flanked domain
I1A49_RS17565	COG4585	Histidine kinase
I1A49_RS17570	COG2197	response regulator
I1A49_RS17600	COG3962	Belongs to the TPP enzyme family
I1A49_RS17605	COG3718	enzyme involved in inositol metabolism
I1A49_RS17615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS17640	COG0673	inositol 2-dehydrogenase activity
I1A49_RS17650	COG2409	Drug exporters of the RND superfamily
I1A49_RS17675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1A49_RS17680	COG1609	Transcriptional regulator
I1A49_RS17685	COG1129	ABC transporter
I1A49_RS17690	COG1879	ABC-type sugar transport system periplasmic component
I1A49_RS17695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS17700	COG1869	D-ribose catabolic process
I1A49_RS17705	COG0583	DNA-binding transcription factor activity
I1A49_RS17710	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS17725	COG0673	inositol 2-dehydrogenase activity
I1A49_RS17740	COG0395	ABC-type sugar transport system, permease component
I1A49_RS17745	COG1175	transmembrane transport
I1A49_RS17770	COG1609	Transcriptional regulator
I1A49_RS17785	COG1846	Transcriptional regulator
I1A49_RS17785	COG0456	acetyltransferase
I1A49_RS17825	COG1472	Belongs to the glycosyl hydrolase 3 family
I1A49_RS17850	COG2197	response regulator
I1A49_RS17855	COG4585	Histidine kinase
I1A49_RS17875	COG0640	Transcriptional regulator
I1A49_RS17890	COG1278	Cold shock
I1A49_RS17895	COG0513	Belongs to the DEAD box helicase family
I1A49_RS17905	COG1946	Acyl-CoA thioesterase
I1A49_RS17920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I1A49_RS17940	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS17960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1A49_RS17965	COG0589	response to stress
I1A49_RS17975	COG4977	sequence-specific DNA binding
I1A49_RS17980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I1A49_RS18090	COG1309	transcriptional regulator
I1A49_RS18095	COG0789	Transcriptional regulator
I1A49_RS18115	COG5297	Belongs to the glycosyl hydrolase family 6
I1A49_RS18115	COG4733	cellulase activity
I1A49_RS18125	COG5297	Belongs to the glycosyl hydrolase family 6
I1A49_RS18155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1A49_RS18160	COG3979	chitinase
I1A49_RS18250	COG4977	sequence-specific DNA binding
I1A49_RS18275	COG4585	Histidine kinase
I1A49_RS18280	COG2197	response regulator
I1A49_RS18295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS18315	COG3473	Maleate cis-trans isomerase
I1A49_RS18330	COG0154	amidase activity
I1A49_RS18340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A49_RS18345	COG0765	amino acid transport
I1A49_RS18350	COG0765	amino acid transport
I1A49_RS18355	COG1126	abc transporter atp-binding protein
I1A49_RS18375	COG2267	carboxylic ester hydrolase activity
I1A49_RS18390	COG4770	biotin carboxylase activity
I1A49_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS18410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1A49_RS18420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS18430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS18450	COG0300	oxidoreductase activity
I1A49_RS18460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS18475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS18480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS18485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS18495	COG0477	Major facilitator Superfamily
I1A49_RS18500	COG1063	alcohol dehydrogenase
I1A49_RS18515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1A49_RS18520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS18555	COG3397	chitin binding
I1A49_RS18585	COG2186	Transcriptional regulator
I1A49_RS18595	COG2197	response regulator
I1A49_RS18600	COG4585	Histidine kinase
I1A49_RS18645	COG0673	inositol 2-dehydrogenase activity
I1A49_RS18650	COG4702	Belongs to the UPF0303 family
I1A49_RS18670	COG3764	Sortase (surface protein transpeptidase)
I1A49_RS18675	COG2733	membrane
I1A49_RS18705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A49_RS18710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1A49_RS18730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I1A49_RS18740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I1A49_RS18745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A49_RS18750	COG1263	PTS System
I1A49_RS18760	COG2274	protein secretion by the type I secretion system
I1A49_RS18770	COG1234	tRNA 3'-trailer cleavage
I1A49_RS18790	COG1113	amino acid transport
I1A49_RS18800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I1A49_RS18810	COG1335	isochorismatase
I1A49_RS18850	COG1064	alcohol dehydrogenase
I1A49_RS18855	COG0277	FAD linked oxidase domain protein
I1A49_RS18865	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I1A49_RS18905	COG3654	unkown
I1A49_RS18920	COG2855	membrane
I1A49_RS18930	COG0583	DNA-binding transcription factor activity
I1A49_RS18960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS18975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I1A49_RS18980	COG0395	ABC-type sugar transport system, permease component
I1A49_RS19005	COG1678	Uncharacterized ACR, COG1678
I1A49_RS19010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1A49_RS19015	COG0776	regulation of translation
I1A49_RS19025	COG1278	Cold shock
I1A49_RS19030	COG3973	AAA domain
I1A49_RS19055	COG2223	nitrite transmembrane transporter activity
I1A49_RS19070	COG0583	DNA-binding transcription factor activity
I1A49_RS19080	COG0583	DNA-binding transcription factor activity
I1A49_RS19095	COG0395	ABC-type sugar transport system, permease component
I1A49_RS19100	COG1501	Belongs to the glycosyl hydrolase 31 family
I1A49_RS19105	COG2027	D-alanyl-D-alanine carboxypeptidase
I1A49_RS19120	COG0604	alcohol dehydrogenase
I1A49_RS19165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I1A49_RS19170	COG0793	Belongs to the peptidase S41A family
I1A49_RS19180	COG2884	Cell division ATP-binding protein ftsE
I1A49_RS19195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I1A49_RS19205	COG0515	serine threonine protein kinase
I1A49_RS19225	COG1653	transport
I1A49_RS19230	COG1175	transmembrane transport
I1A49_RS19235	COG0395	ABC-type sugar transport system, permease component
I1A49_RS19270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A49_RS19270	COG0463	Glycosyl transferase, family 2
I1A49_RS19305	COG0463	Glycosyl transferase, family 2
I1A49_RS19305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A49_RS19310	COG2902	Dehydrogenase
I1A49_RS19315	COG0693	protein deglycase activity
I1A49_RS19335	COG0653	protein targeting
I1A49_RS19345	COG3214	Protein conserved in bacteria
I1A49_RS19350	COG2197	response regulator
I1A49_RS19355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I1A49_RS19365	COG0823	Involved in the tonB-independent uptake of proteins
I1A49_RS19370	COG5002	protein histidine kinase activity
I1A49_RS19375	COG0745	RESPONSE REGULATOR receiver
I1A49_RS19380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I1A49_RS19410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I1A49_RS19425	COG1482	cell wall glycoprotein biosynthetic process
I1A49_RS19435	COG2835	tetraacyldisaccharide 4'-kinase activity
I1A49_RS19440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1A49_RS19445	COG1620	l-lactate permease
I1A49_RS19480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I1A49_RS19485	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I1A49_RS19485	COG0778	Nitroreductase
I1A49_RS19510	COG1316	TRANSCRIPTIONal
I1A49_RS19515	COG1316	TRANSCRIPTIONal
I1A49_RS19530	COG1316	TRANSCRIPTIONal
I1A49_RS19535	COG1607	acyl-coa hydrolase
I1A49_RS19540	COG1316	TRANSCRIPTIONal
I1A49_RS19550	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I1A49_RS19575	COG2205	protein histidine kinase activity
I1A49_RS19580	COG0745	RESPONSE REGULATOR receiver
I1A49_RS19585	COG3104	oligopeptide transport
I1A49_RS19615	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A49_RS19620	COG1191	sigma factor activity
I1A49_RS19625	COG1228	amidohydrolase
I1A49_RS19635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I1A49_RS19640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I1A49_RS19645	COG0604	alcohol dehydrogenase
I1A49_RS19660	COG0019	diaminopimelate decarboxylase activity
I1A49_RS19675	COG2986	histidine ammonia-lyase
I1A49_RS19685	COG1174	glycine betaine transport
I1A49_RS19700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I1A49_RS19705	COG3629	intracellular signal transduction
I1A49_RS19705	COG3903	Transcriptional regulator
I1A49_RS19720	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS19735	COG2755	lipolytic protein G-D-S-L family
I1A49_RS19740	COG0183	Belongs to the thiolase family
I1A49_RS19770	COG1136	(ABC) transporter
I1A49_RS19775	COG0577	efflux transmembrane transporter activity
I1A49_RS19775	COG1136	(ABC) transporter
I1A49_RS19780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I1A49_RS19785	COG1252	NADH dehydrogenase
I1A49_RS19805	COG0148	phosphopyruvate hydratase activity
I1A49_RS19815	COG1652	LysM domain
I1A49_RS19820	COG2124	cytochrome p450
I1A49_RS19855	COG3033	Beta-eliminating lyase
I1A49_RS19905	COG2986	histidine ammonia-lyase
I1A49_RS19915	COG1024	Enoyl-CoA hydratase
I1A49_RS19925	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I1A49_RS19935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I1A49_RS19945	COG0424	maF-like protein
I1A49_RS19955	COG4770	biotin carboxylase activity
I1A49_RS19990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1A49_RS20005	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS20010	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS20015	COG2159	amidohydrolase
I1A49_RS20025	COG2814	Major facilitator Superfamily
I1A49_RS20025	COG0477	Major facilitator Superfamily
I1A49_RS20035	COG1595	DNA-templated transcription, initiation
I1A49_RS20040	COG0745	RESPONSE REGULATOR receiver
I1A49_RS20045	COG2205	protein histidine kinase activity
I1A49_RS20070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I1A49_RS20080	COG2814	Major facilitator Superfamily
I1A49_RS20085	COG0583	DNA-binding transcription factor activity
I1A49_RS20100	COG1079	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS20105	COG4603	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS20110	COG3845	ABC transporter
I1A49_RS20115	COG1744	ABC transporter substrate-binding protein PnrA-like
I1A49_RS20120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I1A49_RS20120	COG1473	amidohydrolase
I1A49_RS20130	COG2089	acid synthase
I1A49_RS20135	COG1083	cytidylyl-transferase
I1A49_RS20145	COG1216	Glycosyl transferase, family 2
I1A49_RS20155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I1A49_RS20165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS20175	COG1063	alcohol dehydrogenase
I1A49_RS20180	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS20190	COG3265	gluconokinase activity
I1A49_RS20195	COG2186	Transcriptional regulator
I1A49_RS20205	COG1316	TRANSCRIPTIONal
I1A49_RS20240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS20240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS20275	COG2009	succinate dehydrogenase
I1A49_RS20285	COG1053	succinate dehydrogenase
I1A49_RS20290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I1A49_RS20300	COG1408	metallophosphoesterase
I1A49_RS20305	COG1686	Belongs to the peptidase S11 family
I1A49_RS20310	COG1295	ribonuclease BN
I1A49_RS20340	COG0180	Tryptophanyl-tRNA synthetase
I1A49_RS20350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1A49_RS20355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1A49_RS20360	COG0754	glutathionylspermidine amidase activity
I1A49_RS20370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A49_RS20375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A49_RS20395	COG4175	Glycine betaine
I1A49_RS20395	COG0517	IMP dehydrogenase activity
I1A49_RS20405	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS20430	COG0039	L-malate dehydrogenase activity
I1A49_RS20445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I1A49_RS20450	COG0138	bifunctional purine biosynthesis protein purh
I1A49_RS20475	COG0045	succinate-CoA ligase (ADP-forming) activity
I1A49_RS20500	COG0714	Associated with various cellular activities
I1A49_RS20515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS20525	COG0739	heme binding
I1A49_RS20575	COG2197	response regulator
I1A49_RS20595	COG0515	serine threonine protein kinase
I1A49_RS20620	COG0519	Catalyzes the synthesis of GMP from XMP
I1A49_RS20620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I1A49_RS20640	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS20650	COG0515	serine threonine protein kinase
I1A49_RS20670	COG2197	response regulator
I1A49_RS20675	COG3851	Histidine kinase
I1A49_RS20680	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A49_RS20755	COG0596	Alpha beta hydrolase
I1A49_RS20755	COG2945	thiolester hydrolase activity
I1A49_RS20765	COG4821	SIS domain
I1A49_RS20775	COG0259	pyridoxamine-phosphate oxidase activity
I1A49_RS20790	COG1024	Enoyl-CoA hydratase
I1A49_RS20795	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS20810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I1A49_RS20845	COG0277	FAD linked oxidase domain protein
I1A49_RS20845	COG0247	lactate metabolic process
I1A49_RS20850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I1A49_RS20865	COG0667	Aldo Keto reductase
I1A49_RS20885	COG2252	PERMEase
I1A49_RS20910	COG2814	Major facilitator Superfamily
I1A49_RS20920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I1A49_RS20925	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I1A49_RS20930	COG1278	Cold shock
I1A49_RS20945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS20950	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS20955	COG1120	ATPase activity
I1A49_RS20985	COG1061	Type III restriction enzyme res subunit
I1A49_RS20990	COG3973	AAA domain
I1A49_RS21025	COG0475	glutathione-regulated potassium exporter activity
I1A49_RS21035	COG3851	Histidine kinase
I1A49_RS21040	COG2197	response regulator
I1A49_RS21055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I1A49_RS21060	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I1A49_RS21065	COG0459	protein refolding
I1A49_RS21070	COG1278	Cold shock
I1A49_RS21085	COG0463	Glycosyl transferase, family 2
I1A49_RS21095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A49_RS21095	COG1877	trehalose-phosphatase activity
I1A49_RS21110	COG1940	carbohydrate kinase activity
I1A49_RS21135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A49_RS21140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I1A49_RS21155	COG1309	transcriptional regulator
I1A49_RS21160	COG1064	alcohol dehydrogenase
I1A49_RS21205	COG3842	ATPase activity
I1A49_RS21225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1A49_RS21230	COG0215	cysteine-tRNA ligase activity
I1A49_RS21235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I1A49_RS21240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I1A49_RS21245	COG1329	Transcriptional regulator
I1A49_RS21260	COG5002	protein histidine kinase activity
I1A49_RS21275	COG2319	Wd-40 repeat
I1A49_RS21275	COG4249	Peptidase C14 caspase catalytic subunit p20
I1A49_RS21290	COG1216	Glycosyl transferase, family 2
I1A49_RS21290	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS21295	COG2188	Transcriptional regulator
I1A49_RS21305	COG0640	Transcriptional regulator
I1A49_RS21340	COG0588	phosphoglycerate mutase activity
I1A49_RS21375	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS21385	COG0531	amino acid
I1A49_RS21395	COG0667	Aldo Keto reductase
I1A49_RS21410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A49_RS21425	COG1126	abc transporter atp-binding protein
I1A49_RS21430	COG0406	alpha-ribazole phosphatase activity
I1A49_RS21430	COG0494	nUDIX hydrolase
I1A49_RS21440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I1A49_RS21445	COG0454	-acetyltransferase
I1A49_RS21445	COG0456	acetyltransferase
I1A49_RS21450	COG4804	nuclease activity
I1A49_RS21455	COG0737	Belongs to the 5'-nucleotidase family
I1A49_RS21470	COG1024	Enoyl-CoA hydratase
I1A49_RS21475	COG1733	regulation of RNA biosynthetic process
I1A49_RS21525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I1A49_RS21545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I1A49_RS21555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I1A49_RS21560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I1A49_RS21575	COG0640	Transcriptional regulator
I1A49_RS21585	COG2197	response regulator
I1A49_RS21600	COG0649	NAD binding
I1A49_RS21615	COG1174	glycine betaine transport
I1A49_RS21620	COG1174	glycine betaine transport
I1A49_RS21625	COG1125	glycine betaine transport
I1A49_RS21625	COG0517	IMP dehydrogenase activity
I1A49_RS21650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I1A49_RS21655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I1A49_RS21665	COG0302	gtp cyclohydrolase
I1A49_RS21680	COG0037	tRNA processing
I1A49_RS21690	COG2027	D-alanyl-D-alanine carboxypeptidase
I1A49_RS21695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I1A49_RS21705	COG0586	Pfam SNARE associated Golgi protein
I1A49_RS21710	COG0789	Transcriptional regulator
I1A49_RS21720	COG0076	glutamate decarboxylase activity
I1A49_RS21745	COG2318	DinB family
I1A49_RS21750	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS21775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A49_RS21775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A49_RS21780	COG1077	Cell shape determining protein MreB Mrl
I1A49_RS21795	COG1595	DNA-templated transcription, initiation
I1A49_RS21810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I1A49_RS21865	COG0671	phosphoesterase, PA-phosphatase related
I1A49_RS21870	COG2197	response regulator
I1A49_RS21875	COG4585	Histidine kinase
I1A49_RS21900	COG1191	sigma factor activity
I1A49_RS21905	COG0640	Transcriptional regulator
I1A49_RS21920	COG2271	Major facilitator Superfamily
I1A49_RS21925	COG0006	proline dipeptidase activity
I1A49_RS21935	COG2423	ornithine cyclodeaminase activity
I1A49_RS21940	COG0066	3-isopropylmalate dehydratase activity
I1A49_RS21945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1A49_RS21950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1A49_RS21955	COG0066	3-isopropylmalate dehydratase activity
I1A49_RS21965	COG2271	Major facilitator Superfamily
I1A49_RS21970	COG0129	dihydroxy-acid dehydratase activity
I1A49_RS21975	COG3573	Dehydrogenase
I1A49_RS22020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I1A49_RS22030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1A49_RS22030	COG1754	DNA topoisomerase type I activity
I1A49_RS22040	COG2890	protein-(glutamine-N5) methyltransferase activity
I1A49_RS22050	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I1A49_RS22055	COG2172	sigma factor antagonist activity
I1A49_RS22060	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A49_RS22065	COG1205	dead DEAH box helicase
I1A49_RS22065	COG1111	helicase
I1A49_RS22130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS22135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I1A49_RS22145	COG2267	carboxylic ester hydrolase activity
I1A49_RS22170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A49_RS22195	COG0003	Pfam Anion-transporting ATPase
I1A49_RS22205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A49_RS22215	COG1408	metallophosphoesterase
I1A49_RS22265	COG2124	cytochrome p450
I1A49_RS22310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I1A49_RS22315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I1A49_RS22385	COG4585	Histidine kinase
I1A49_RS22390	COG2197	response regulator
I1A49_RS22405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I1A49_RS22425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A49_RS22450	COG0501	Belongs to the peptidase M48B family
I1A49_RS22460	COG2124	cytochrome p450
I1A49_RS22465	COG0702	epimerase
I1A49_RS22480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I1A49_RS22515	COG0205	6-phosphofructokinase activity
I1A49_RS22525	COG1191	sigma factor activity
I1A49_RS22530	COG1191	sigma factor activity
I1A49_RS22565	COG0477	Major facilitator Superfamily
I1A49_RS22570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I1A49_RS22570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I1A49_RS22580	COG2205	protein histidine kinase activity
I1A49_RS22585	COG0745	RESPONSE REGULATOR receiver
I1A49_RS22630	COG0515	serine threonine protein kinase
I1A49_RS22650	COG2188	Transcriptional regulator
I1A49_RS22675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A49_RS22675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A49_RS22690	COG2188	Transcriptional regulator
I1A49_RS22725	COG0582	viral genome integration into host DNA
I1A49_RS22745	COG5000	phosphorelay sensor kinase activity
I1A49_RS22750	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS22755	COG1595	DNA-templated transcription, initiation
I1A49_RS22815	COG2186	Transcriptional regulator
I1A49_RS22935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A49_RS22950	COG0653	protein targeting
I1A49_RS22965	COG0006	proline dipeptidase activity
I1A49_RS22970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A49_RS22975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A49_RS22995	COG1999	signal sequence binding
I1A49_RS23005	COG2372	response to copper ion
I1A49_RS23010	COG2837	iron assimilation
I1A49_RS23015	COG0077	Prephenate dehydratase
I1A49_RS23020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I1A49_RS23025	COG0561	phosphatase activity
I1A49_RS23050	COG2807	transmembrane transport
I1A49_RS23070	COG1131	(ABC) transporter
I1A49_RS23080	COG0501	Belongs to the peptidase M48B family
I1A49_RS23090	COG0561	phosphatase activity
I1A49_RS23105	COG4988	ABC transporter
I1A49_RS23110	COG1294	oxidase, subunit
I1A49_RS23115	COG1271	oxidase subunit
I1A49_RS23120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A49_RS23125	COG1609	Transcriptional regulator
I1A49_RS23145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I1A49_RS23165	COG0662	Cupin 2, conserved barrel domain protein
I1A49_RS23170	COG1950	PFAM Membrane protein of
I1A49_RS23175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1A49_RS23180	COG0626	cystathionine gamma-synthase activity
I1A49_RS23250	COG0242	peptide deformylase activity
I1A49_RS23255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1A49_RS23260	COG0305	Participates in initiation and elongation during chromosome replication
I1A49_RS23270	COG0359	binds to the 23S rRNA
I1A49_RS23275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I1A49_RS23280	COG0629	single-stranded DNA binding
I1A49_RS23285	COG0360	Binds together with S18 to 16S ribosomal RNA
I1A49_RS23310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A49_RS23320	COG1260	myo-inositol-1-phosphate synthase
I1A49_RS23330	COG0617	tRNA 3'-terminal CCA addition
I1A49_RS23345	COG0515	serine threonine protein kinase
I1A49_RS23345	COG2815	serine threonine protein kinase
I1A49_RS23350	COG1595	DNA-templated transcription, initiation
I1A49_RS23360	COG0492	ferredoxin-NADP+ reductase activity
I1A49_RS23365	COG3118	belongs to the thioredoxin family
I1A49_RS23380	COG1192	Involved in chromosome partitioning
I1A49_RS23385	COG0357	Ribosomal RNA small subunit methyltransferase G
I1A49_RS23395	COG0706	membrane insertase activity
I1A49_RS23400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I1A49_RS23405	COG0594	ribonuclease P activity
I1A49_RS23410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I1A49_RS23420	COG0592	DNA-directed DNA polymerase activity
I1A49_RS23425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I1A49_RS23430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I1A49_RS23435	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I1A49_RS23440	COG0187	DNA topoisomerase II activity
I1A49_RS23445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1A49_RS23470	COG0515	serine threonine protein kinase
I1A49_RS23500	COG0705	Rhomboid family
I1A49_RS23515	COG3764	Sortase (surface protein transpeptidase)
I1A49_RS23535	COG3764	Sortase (surface protein transpeptidase)
I1A49_RS23540	COG0515	serine threonine protein kinase
I1A49_RS23545	COG0768	penicillin binding
I1A49_RS23575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I1A49_RS23580	COG1733	regulation of RNA biosynthetic process
I1A49_RS23605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1A49_RS23610	COG2151	metal-sulfur cluster biosynthetic enzyme
I1A49_RS23615	COG3396	Phenylacetate-CoA oxygenase
I1A49_RS23620	COG3460	Phenylacetate-CoA oxygenase
I1A49_RS23625	COG3396	Phenylacetate-CoA oxygenase
I1A49_RS23650	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS23655	COG1309	transcriptional regulator
I1A49_RS23660	COG1522	sequence-specific DNA binding
I1A49_RS23680	COG0746	molybdenum cofactor guanylyltransferase activity
I1A49_RS23690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I1A49_RS23695	COG3321	synthase
I1A49_RS23695	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS23695	COG0604	alcohol dehydrogenase
I1A49_RS23710	COG0515	serine threonine protein kinase
I1A49_RS23715	COG0515	serine threonine protein kinase
I1A49_RS23735	COG0022	dehydrogenase e1 component
I1A49_RS23785	COG1362	aminopeptidase activity
I1A49_RS23800	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS23810	COG1741	Belongs to the pirin family
I1A49_RS23830	COG2837	iron assimilation
I1A49_RS23840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I1A49_RS23850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A49_RS23885	COG1793	dna ligase
I1A49_RS23895	COG3290	protein histidine kinase activity
I1A49_RS23905	COG2018	Roadblock/LC7 domain
I1A49_RS23955	COG2197	response regulator
I1A49_RS23960	COG4585	Histidine kinase
I1A49_RS24005	COG2205	protein histidine kinase activity
I1A49_RS24035	COG0725	ABC transporter, periplasmic molybdate-binding protein
I1A49_RS24080	COG0531	amino acid
I1A49_RS24095	COG0583	DNA-binding transcription factor activity
I1A49_RS24120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I1A49_RS24120	COG0515	serine threonine protein kinase
I1A49_RS24150	COG3629	intracellular signal transduction
I1A49_RS24150	COG3903	Transcriptional regulator
I1A49_RS24170	COG0726	polysaccharide deacetylase
I1A49_RS24195	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS24245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A49_RS24255	COG0179	Fumarylacetoacetate (FAA) hydrolase
I1A49_RS24295	COG3547	Transposase (IS116 IS110 IS902 family)
I1A49_RS24335	COG0717	Belongs to the dCTP deaminase family
I1A49_RS24340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I1A49_RS24355	COG3290	protein histidine kinase activity
I1A49_RS24360	COG0247	lactate metabolic process
I1A49_RS24360	COG2181	nitrate reductase activity
I1A49_RS24365	COG0443	Heat shock 70 kDa protein
I1A49_RS24370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I1A49_RS24375	COG0484	heat shock protein binding
I1A49_RS24380	COG0789	Transcriptional regulator
I1A49_RS24390	COG0477	Major facilitator Superfamily
I1A49_RS24400	COG0542	response to heat
I1A49_RS24455	COG3547	Transposase (IS116 IS110 IS902 family)
I1A49_RS24490	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I1A49_RS24505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1A49_RS24510	COG0191	fructose-bisphosphate aldolase activity
I1A49_RS24515	COG0477	Major facilitator Superfamily
I1A49_RS24530	COG3844	kynureninase activity
I1A49_RS24545	COG2197	response regulator
I1A49_RS24555	COG3559	Exporter of polyketide antibiotics
I1A49_RS24560	COG1131	(ABC) transporter
I1A49_RS24575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I1A49_RS24580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I1A49_RS24580	COG0515	serine threonine protein kinase
I1A49_RS24595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I1A49_RS24600	COG1802	Transcriptional regulator
I1A49_RS24615	COG0151	Belongs to the GarS family
I1A49_RS24635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I1A49_RS24665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1A49_RS24670	COG0047	phosphoribosylformylglycinamidine synthase activity
I1A49_RS24675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1A49_RS24695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I1A49_RS24705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I1A49_RS24730	COG1643	Atp-dependent helicase
I1A49_RS24780	COG0513	Belongs to the DEAD box helicase family
I1A49_RS24825	COG0667	Aldo Keto reductase
I1A49_RS24845	COG0270	DNA (cytosine-5-)-methyltransferase activity
I1A49_RS24885	COG1376	ErfK ybiS ycfS ynhG family protein
I1A49_RS24900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I1A49_RS24905	COG0579	oxidoreductase
I1A49_RS24930	COG1252	NADH dehydrogenase
I1A49_RS24945	COG1846	Transcriptional regulator
I1A49_RS25000	COG0739	heme binding
I1A49_RS25000	COG0741	lytic transglycosylase activity
I1A49_RS25000	COG1196	nuclear chromosome segregation
I1A49_RS25005	COG0671	phosphoesterase, PA-phosphatase related
I1A49_RS25010	COG0277	FAD linked oxidase domain protein
I1A49_RS25025	COG1937	Protein conserved in bacteria
I1A49_RS25035	COG0306	phosphate transporter
I1A49_RS25040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I1A49_RS25065	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I1A49_RS25160	COG4941	Belongs to the sigma-70 factor family
I1A49_RS25165	COG0667	Aldo Keto reductase
I1A49_RS25175	COG2249	NAD(P)H dehydrogenase (quinone) activity
I1A49_RS25205	COG4552	Acetyltransferase involved in intracellular survival and related
I1A49_RS25215	COG1490	D-aminoacyl-tRNA deacylase activity
I1A49_RS25225	COG0735	belongs to the Fur family
I1A49_RS25230	COG3485	protocatechuate 3,4-dioxygenase
I1A49_RS25250	COG2897	thiosulfate sulfurtransferase activity
I1A49_RS25285	COG0745	RESPONSE REGULATOR receiver
I1A49_RS25290	COG1609	Transcriptional regulator
I1A49_RS25295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A49_RS25310	COG1132	(ABC) transporter
I1A49_RS25320	COG0724	RNA recognition motif
I1A49_RS25375	COG0739	heme binding
I1A49_RS25395	COG0346	lactoylglutathione lyase activity
I1A49_RS25400	COG2205	protein histidine kinase activity
I1A49_RS25405	COG0745	RESPONSE REGULATOR receiver
I1A49_RS25415	COG1595	DNA-templated transcription, initiation
I1A49_RS25420	COG1194	a g-specific adenine glycosylase
I1A49_RS25430	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I1A49_RS25450	COG0248	Ppx GppA phosphatase
I1A49_RS25455	COG1082	Xylose isomerase domain protein TIM barrel
I1A49_RS25465	COG0129	dihydroxy-acid dehydratase activity
I1A49_RS25495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1A49_RS25500	COG0180	Tryptophanyl-tRNA synthetase
I1A49_RS25520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A49_RS25530	COG0123	including yeast histone deacetylase and acetoin utilization protein
I1A49_RS25580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I1A49_RS25585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I1A49_RS25590	COG0181	hydroxymethylbilane synthase activity
I1A49_RS25595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I1A49_RS25595	COG1648	precorrin-2 dehydrogenase activity
I1A49_RS25600	COG0113	porphobilinogen synthase activity
I1A49_RS25605	COG1072	(Pantothenic acid kinase))
I1A49_RS25625	COG0018	arginyl-trna synthetase
I1A49_RS25630	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I1A49_RS25650	COG1690	Belongs to the RtcB family
I1A49_RS25660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A49_RS25700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I1A49_RS25705	COG0406	alpha-ribazole phosphatase activity
I1A49_RS25715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A49_RS25725	COG1333	cytochrome c biogenesis protein
I1A49_RS25730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1A49_RS25740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I1A49_RS25745	COG0109	protoheme IX farnesyltransferase activity
I1A49_RS25750	COG0163	prenyltransferase activity
I1A49_RS25765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1A49_RS25770	COG1573	uracil-dna glycosylase
I1A49_RS25785	COG1301	dicarboxylic acid transport
I1A49_RS25790	COG2076	Multidrug Resistance protein
I1A49_RS25800	COG1309	transcriptional regulator
I1A49_RS25820	COG1278	Cold shock
I1A49_RS25825	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I1A49_RS25835	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1A49_RS25845	COG2226	methyltransferase
I1A49_RS25875	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1A49_RS25880	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1A49_RS25885	COG0649	NAD binding
I1A49_RS25895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I1A49_RS25900	COG1034	ATP synthesis coupled electron transport
I1A49_RS25905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I1A49_RS25910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1A49_RS25915	COG0839	Belongs to the complex I subunit 6 family
I1A49_RS25920	COG0713	ATP synthesis coupled electron transport
I1A49_RS25925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1A49_RS25935	COG1007	ATP synthesis coupled electron transport
I1A49_RS25955	COG0492	ferredoxin-NADP+ reductase activity
I1A49_RS25960	COG0142	geranyltranstransferase activity
I1A49_RS25990	COG0702	epimerase
I1A49_RS25995	COG0531	amino acid
I1A49_RS26000	COG1013	pyruvate-flavodoxin oxidoreductase activity
I1A49_RS26005	COG0674	pyruvate-flavodoxin oxidoreductase activity
I1A49_RS26005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I1A49_RS26015	COG4585	Histidine kinase
I1A49_RS26020	COG4585	Histidine kinase
I1A49_RS26025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1A49_RS26030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1A49_RS26035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1A49_RS26040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I1A49_RS26050	COG0839	Belongs to the complex I subunit 6 family
I1A49_RS26055	COG0713	ATP synthesis coupled electron transport
I1A49_RS26070	COG1007	ATP synthesis coupled electron transport
I1A49_RS26075	COG0501	Belongs to the peptidase M48B family
I1A49_RS26080	COG3304	Inner membrane component domain
I1A49_RS26085	COG1666	GTP binding
I1A49_RS26110	COG1970	mechanosensitive ion channel activity
I1A49_RS26125	COG0702	epimerase
I1A49_RS26145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1A49_RS26150	COG2030	dehydratase
I1A49_RS26160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I1A49_RS26165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I1A49_RS26170	COG0436	Aminotransferase
I1A49_RS26190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I1A49_RS26195	COG0081	regulation of translation
I1A49_RS26205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I1A49_RS26210	COG0222	ribosome binding
I1A49_RS26215	COG0085	RNA polymerase activity
I1A49_RS26220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1A49_RS26250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I1A49_RS26255	COG0049	tRNA binding
I1A49_RS26260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I1A49_RS26265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I1A49_RS26280	COG0051	transcription antitermination factor activity, RNA binding
I1A49_RS26285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I1A49_RS26290	COG0088	Forms part of the polypeptide exit tunnel
I1A49_RS26295	COG0089	rRNA binding
I1A49_RS26300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I1A49_RS26305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I1A49_RS26310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I1A49_RS26315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I1A49_RS26320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I1A49_RS26325	COG0255	Belongs to the universal ribosomal protein uL29 family
I1A49_RS26330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I1A49_RS26335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I1A49_RS26340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I1A49_RS26345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I1A49_RS26350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I1A49_RS26355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I1A49_RS26360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I1A49_RS26365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I1A49_RS26370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I1A49_RS26380	COG0200	Binds to the 23S rRNA
I1A49_RS26390	COG0563	adenylate kinase activity
I1A49_RS26400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I1A49_RS26405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I1A49_RS26410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I1A49_RS26415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I1A49_RS26420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I1A49_RS26425	COG0202	RNA polymerase activity
I1A49_RS26430	COG0203	ribosomal protein L17
I1A49_RS26435	COG0101	tRNA pseudouridine synthase activity
I1A49_RS26440	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A49_RS26445	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A49_RS26450	COG2172	sigma factor antagonist activity
I1A49_RS26460	COG2208	phosphoserine phosphatase activity
I1A49_RS26460	COG2770	Histidine kinase
I1A49_RS26485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I1A49_RS26490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I1A49_RS26495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1A49_RS26505	COG1072	(Pantothenic acid kinase))
I1A49_RS26510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1A49_RS26515	COG0736	holo-[acyl-carrier-protein] synthase activity
I1A49_RS26540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I1A49_RS26550	COG0802	atpase or kinase
I1A49_RS26575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I1A49_RS26585	COG0583	DNA-binding transcription factor activity
I1A49_RS26590	COG0667	Aldo Keto reductase
I1A49_RS26600	COG0596	Alpha beta hydrolase
I1A49_RS26650	COG0726	polysaccharide deacetylase
I1A49_RS26655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1A49_RS26660	COG0459	protein refolding
I1A49_RS26665	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS26675	COG0583	DNA-binding transcription factor activity
I1A49_RS26685	COG2197	response regulator
I1A49_RS26690	COG1595	DNA-templated transcription, initiation
I1A49_RS26700	COG0516	GMP reductase activity
I1A49_RS26715	COG1077	Cell shape determining protein MreB Mrl
I1A49_RS26730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I1A49_RS26755	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS26760	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS26775	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS26780	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS26805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A49_RS26810	COG1024	Enoyl-CoA hydratase
I1A49_RS26820	COG2072	flavoprotein involved in K transport
I1A49_RS26835	COG0259	pyridoxamine-phosphate oxidase activity
I1A49_RS26845	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS26855	COG1309	transcriptional regulator
I1A49_RS26880	COG1024	Enoyl-CoA hydratase
I1A49_RS26960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1A49_RS27010	COG1686	Belongs to the peptidase S11 family
I1A49_RS27020	COG1653	transport
I1A49_RS27035	COG0515	serine threonine protein kinase
I1A49_RS27060	COG1309	transcriptional regulator
I1A49_RS27070	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I1A49_RS27075	COG1793	dna ligase
I1A49_RS27075	COG3285	dna ligase
I1A49_RS27080	COG1793	dna ligase
I1A49_RS27085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I1A49_RS27090	COG0640	Transcriptional regulator
I1A49_RS27105	COG0824	Thioesterase
I1A49_RS27105	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS27110	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS27115	COG3246	L-lysine catabolic process to acetate
I1A49_RS27120	COG1309	transcriptional regulator
I1A49_RS27125	COG0515	serine threonine protein kinase
I1A49_RS27140	COG0596	Alpha beta hydrolase
I1A49_RS27165	COG0640	Transcriptional regulator
I1A49_RS27185	COG0395	ABC-type sugar transport system, permease component
I1A49_RS27190	COG1175	transmembrane transport
I1A49_RS27220	COG0494	nUDIX hydrolase
I1A49_RS27255	COG4221	oxidoreductase activity
I1A49_RS27285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I1A49_RS27335	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I1A49_RS27395	COG1846	Transcriptional regulator
I1A49_RS27400	COG3384	dioxygenase
I1A49_RS27420	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS27425	COG1349	DNA-binding transcription factor activity
I1A49_RS27430	COG1105	Belongs to the carbohydrate kinase PfkB family
I1A49_RS27435	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I1A49_RS27435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A49_RS27435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A49_RS27440	COG3634	alkyl hydroperoxide reductase activity
I1A49_RS27445	COG3191	aminopeptidase activity
I1A49_RS27450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS27460	COG1970	mechanosensitive ion channel activity
I1A49_RS27470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I1A49_RS27480	COG3263	regulation of cellular component size
I1A49_RS27490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I1A49_RS27495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I1A49_RS27505	COG0315	cyclic pyranopterin monophosphate synthase activity
I1A49_RS27510	COG0521	Mo-molybdopterin cofactor biosynthetic process
I1A49_RS27510	COG0315	cyclic pyranopterin monophosphate synthase activity
I1A49_RS27515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A49_RS27530	COG0783	Belongs to the Dps family
I1A49_RS27550	COG0708	Exodeoxyribonuclease III
I1A49_RS27555	COG0789	Transcriptional regulator
I1A49_RS27560	COG2072	flavoprotein involved in K transport
I1A49_RS27565	COG2267	carboxylic ester hydrolase activity
I1A49_RS27580	COG4946	Tricorn protease homolog
I1A49_RS27580	COG0793	Belongs to the peptidase S41A family
I1A49_RS27590	COG2409	Drug exporters of the RND superfamily
I1A49_RS27595	COG1309	transcriptional regulator
I1A49_RS27605	COG0310	cobalt ion transport
I1A49_RS27615	COG1122	ATPase activity
I1A49_RS27630	COG4166	transmembrane transport
I1A49_RS27730	COG0084	hydrolase, TatD family'
I1A49_RS27735	COG3583	domain protein
I1A49_RS27735	COG3584	3D domain protein
I1A49_RS27740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I1A49_RS27745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I1A49_RS27750	COG0488	(ABC) transporter
I1A49_RS27785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I1A49_RS27790	COG2197	response regulator
I1A49_RS27800	COG4106	trans-aconitate 2-methyltransferase activity
I1A49_RS27810	COG1309	transcriptional regulator
I1A49_RS27820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I1A49_RS27830	COG0193	aminoacyl-tRNA hydrolase activity
I1A49_RS27835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I1A49_RS27840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I1A49_RS27845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1A49_RS27885	COG0477	Major facilitator Superfamily
I1A49_RS27890	COG1136	(ABC) transporter
I1A49_RS27895	COG0577	efflux transmembrane transporter activity
I1A49_RS27945	COG2186	Transcriptional regulator
I1A49_RS27960	COG0698	ribose 5-phosphate isomerase
I1A49_RS27965	COG0149	triose-phosphate isomerase activity
I1A49_RS27970	COG1082	Xylose isomerase domain protein TIM barrel
I1A49_RS27975	COG2084	Dehydrogenase
I1A49_RS28015	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS28025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS28030	COG0601	transmembrane transport
I1A49_RS28060	COG2226	methyltransferase
I1A49_RS28110	COG0494	nUDIX hydrolase
I1A49_RS28130	COG2318	DinB family
I1A49_RS28135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1A49_RS28165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I1A49_RS28180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I1A49_RS28190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A49_RS28200	COG3629	intracellular signal transduction
I1A49_RS28200	COG3903	Transcriptional regulator
I1A49_RS28205	COG1331	Highly conserved protein containing a thioredoxin domain
I1A49_RS28215	COG1272	protein, Hemolysin III
I1A49_RS28220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I1A49_RS28240	COG0601	transmembrane transport
I1A49_RS28245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS28275	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I1A49_RS28290	COG1414	Transcriptional regulator
I1A49_RS28295	COG0251	oxidation-reduction process
I1A49_RS28300	COG2610	gluconate transmembrane transporter activity
I1A49_RS28330	COG1278	Cold shock
I1A49_RS28335	COG0513	Belongs to the DEAD box helicase family
I1A49_RS28400	COG2894	cell division
I1A49_RS28445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I1A49_RS28450	COG1278	Cold shock
I1A49_RS28465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1A49_RS28470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I1A49_RS28485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A49_RS28490	COG0450	alkyl hydroperoxide reductase
I1A49_RS28505	COG1136	(ABC) transporter
I1A49_RS28525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A49_RS28535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I1A49_RS28535	COG1082	Xylose isomerase domain protein TIM barrel
I1A49_RS28540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I1A49_RS28545	COG1309	transcriptional regulator
I1A49_RS28555	COG2264	protein methyltransferase activity
I1A49_RS28565	COG0114	fumarate hydratase activity
I1A49_RS28580	COG3979	chitinase
I1A49_RS28585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I1A49_RS28585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I1A49_RS28610	COG0778	Nitroreductase
I1A49_RS28615	COG1722	exodeoxyribonuclease VII activity
I1A49_RS28620	COG1570	exodeoxyribonuclease VII activity
I1A49_RS28625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I1A49_RS28640	COG0012	GTP binding
I1A49_RS28645	COG4974	Belongs to the 'phage' integrase family
I1A49_RS28655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I1A49_RS28735	COG0577	efflux transmembrane transporter activity
I1A49_RS28760	COG2205	protein histidine kinase activity
I1A49_RS28770	COG1132	(ABC) transporter
I1A49_RS28775	COG0745	RESPONSE REGULATOR receiver
I1A49_RS28800	COG1063	alcohol dehydrogenase
I1A49_RS28805	COG1091	dTDP-4-dehydrorhamnose reductase activity
I1A49_RS28820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I1A49_RS28825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A49_RS28850	COG2223	nitrite transmembrane transporter activity
I1A49_RS28900	COG1053	succinate dehydrogenase
I1A49_RS28920	COG1217	gtp-binding protein TYPA
I1A49_RS28930	COG0601	transmembrane transport
I1A49_RS28935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS28945	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS28990	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS28995	COG0444	Belongs to the ABC transporter superfamily
I1A49_RS29000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS29005	COG0601	transmembrane transport
I1A49_RS29010	COG4166	transmembrane transport
I1A49_RS29030	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS29035	COG0444	Belongs to the ABC transporter superfamily
I1A49_RS29045	COG0747	negative chemotaxis
I1A49_RS29050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS29070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A49_RS29085	COG1131	(ABC) transporter
I1A49_RS29095	COG4585	Histidine kinase
I1A49_RS29100	COG2197	response regulator
I1A49_RS29105	COG2912	Transglutaminase-like superfamily
I1A49_RS29135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I1A49_RS29140	COG1611	Belongs to the LOG family
I1A49_RS29145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I1A49_RS29155	COG0519	Catalyzes the synthesis of GMP from XMP
I1A49_RS29160	COG1024	Enoyl-CoA hydratase
I1A49_RS29175	COG1595	DNA-templated transcription, initiation
I1A49_RS29185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A49_RS29190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1A49_RS29230	COG0598	Magnesium transport protein CorA
I1A49_RS29245	COG0613	PHP domain protein
I1A49_RS29250	COG2095	MarC family integral membrane protein
I1A49_RS29260	COG1432	Conserved Protein
I1A49_RS29370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I1A49_RS29405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1A49_RS29460	COG3480	Lon protease (S16) C-terminal proteolytic domain
I1A49_RS29470	COG1615	UPF0182 protein
I1A49_RS29495	COG0753	catalase activity
I1A49_RS29505	COG0483	inositol monophosphate 1-phosphatase activity
I1A49_RS29520	COG2801	Transposase and inactivated derivatives
I1A49_RS29520	COG3415	Transposase
I1A49_RS29525	COG1162	GTPase activity
I1A49_RS29530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I1A49_RS29540	COG2135	peptidase activity
I1A49_RS29550	COG1595	DNA-templated transcription, initiation
I1A49_RS29555	COG5662	AntiSigma factor
I1A49_RS29575	COG0242	peptide deformylase activity
I1A49_RS29580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1A49_RS29670	COG2188	Transcriptional regulator
I1A49_RS29675	COG2182	Extracellular solute-binding protein
I1A49_RS29680	COG1175	transmembrane transport
I1A49_RS29685	COG0395	ABC-type sugar transport system, permease component
I1A49_RS29690	COG1472	Belongs to the glycosyl hydrolase 3 family
I1A49_RS29695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1A49_RS29710	COG1597	lipid kinase activity
I1A49_RS29750	COG2066	Belongs to the glutaminase family
I1A49_RS29770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1A49_RS29795	COG5640	endopeptidase activity
I1A49_RS29800	COG0583	DNA-binding transcription factor activity
I1A49_RS29850	COG0765	amino acid transport
I1A49_RS29860	COG0281	malic enzyme
I1A49_RS29885	COG3321	synthase
I1A49_RS29885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS29885	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS29885	COG0300	oxidoreductase activity
I1A49_RS29885	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS29900	COG0778	Nitroreductase
I1A49_RS29925	COG0789	Transcriptional regulator
I1A49_RS29940	COG2205	protein histidine kinase activity
I1A49_RS29945	COG0745	RESPONSE REGULATOR receiver
I1A49_RS29960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I1A49_RS30050	COG0477	Major facilitator Superfamily
I1A49_RS30130	COG0745	RESPONSE REGULATOR receiver
I1A49_RS30135	COG0018	arginyl-trna synthetase
I1A49_RS30140	COG0019	diaminopimelate decarboxylase activity
I1A49_RS30145	COG0460	homoserine dehydrogenase
I1A49_RS30150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1A49_RS30155	COG0083	homoserine kinase activity
I1A49_RS30165	COG1316	TRANSCRIPTIONal
I1A49_RS30170	COG0254	rRNA binding
I1A49_RS30175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I1A49_RS30180	COG2890	protein-(glutamine-N5) methyltransferase activity
I1A49_RS30190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1A49_RS30195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1A49_RS30215	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I1A49_RS30220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1A49_RS30225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I1A49_RS30230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I1A49_RS30235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I1A49_RS30240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I1A49_RS30245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I1A49_RS30255	COG2197	response regulator
I1A49_RS30260	COG4585	Histidine kinase
I1A49_RS30290	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS30310	COG0667	Aldo Keto reductase
I1A49_RS30315	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I1A49_RS30365	COG0183	Belongs to the thiolase family
I1A49_RS30380	COG0745	RESPONSE REGULATOR receiver
I1A49_RS30385	COG2205	protein histidine kinase activity
I1A49_RS30440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS30440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS30475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I1A49_RS30480	COG0857	belongs to the CobB CobQ family
I1A49_RS30480	COG0280	phosphate acetyltransferase
I1A49_RS30485	COG0205	6-phosphofructokinase activity
I1A49_RS30505	COG3833	ABC-type maltose transport systems, permease component
I1A49_RS30510	COG1316	TRANSCRIPTIONal
I1A49_RS30530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS30535	COG1309	transcriptional regulator
I1A49_RS30540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I1A49_RS30570	COG1175	transmembrane transport
I1A49_RS30580	COG3469	chitinase activity
I1A49_RS30585	COG4565	transcriptional regulatory protein
I1A49_RS30590	COG3290	protein histidine kinase activity
I1A49_RS30595	COG1301	dicarboxylic acid transport
I1A49_RS30605	COG3629	intracellular signal transduction
I1A49_RS30605	COG3903	Transcriptional regulator
I1A49_RS30610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I1A49_RS30625	COG0366	Alpha amylase catalytic
I1A49_RS30645	COG3401	FG-GAP repeat protein
I1A49_RS30650	COG0058	SHG alpha-glucan phosphorylase activity
I1A49_RS30695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1A49_RS30715	COG3340	Belongs to the peptidase S51 family
I1A49_RS30745	COG1132	(ABC) transporter
I1A49_RS30750	COG1132	(ABC) transporter
I1A49_RS30800	COG1597	lipid kinase activity
I1A49_RS30825	COG1846	Transcriptional regulator
I1A49_RS30830	COG1595	DNA-templated transcription, initiation
I1A49_RS30840	COG1760	l-serine dehydratase
I1A49_RS30845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1A49_RS30850	COG0509	glycine decarboxylation via glycine cleavage system
I1A49_RS30855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I1A49_RS30880	COG4166	transmembrane transport
I1A49_RS30890	COG0444	Belongs to the ABC transporter superfamily
I1A49_RS30895	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS30900	COG2860	membrane
I1A49_RS30915	COG0596	Alpha beta hydrolase
I1A49_RS30940	COG0482	sulfurtransferase activity
I1A49_RS30950	COG0789	Transcriptional regulator
I1A49_RS30955	COG1819	glycosyl
I1A49_RS30965	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS30975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I1A49_RS30985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1A49_RS30990	COG0154	amidase activity
I1A49_RS31000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1A49_RS31010	COG2409	Drug exporters of the RND superfamily
I1A49_RS31020	COG2197	response regulator
I1A49_RS31030	COG2133	pyrroloquinoline quinone binding
I1A49_RS31035	COG0667	Aldo Keto reductase
I1A49_RS31055	COG0440	acetolactate synthase activity
I1A49_RS31060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I1A49_RS31065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A49_RS31115	COG0506	proline dehydrogenase activity
I1A49_RS31120	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS31130	COG0473	3-isopropylmalate dehydrogenase activity
I1A49_RS31135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1A49_RS31140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A49_RS31145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I1A49_RS31165	COG2018	Roadblock/LC7 domain
I1A49_RS31185	COG2018	Roadblock/LC7 domain
I1A49_RS31200	COG0179	Fumarylacetoacetate (FAA) hydrolase
I1A49_RS31205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I1A49_RS31245	COG1414	Transcriptional regulator
I1A49_RS31250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1A49_RS31255	COG0066	3-isopropylmalate dehydratase activity
I1A49_RS31265	COG0776	regulation of translation
I1A49_RS31270	COG1920	GTP binding
I1A49_RS31280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I1A49_RS31285	COG1181	Belongs to the D-alanine--D-alanine ligase family
I1A49_RS31305	COG0351	phosphomethylpyrimidine kinase
I1A49_RS31310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I1A49_RS31320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I1A49_RS31325	COG0742	ribosomal rna small subunit methyltransferase
I1A49_RS31330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I1A49_RS31345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I1A49_RS31350	COG0571	ribonuclease III activity
I1A49_RS31355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1A49_RS31360	COG1733	regulation of RNA biosynthetic process
I1A49_RS31365	COG2340	Cysteine-rich secretory protein family
I1A49_RS31370	COG1254	Belongs to the acylphosphatase family
I1A49_RS31390	COG0477	Major facilitator Superfamily
I1A49_RS31415	COG2197	response regulator
I1A49_RS31445	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I1A49_RS31460	COG0442	prolyl-tRNA aminoacylation
I1A49_RS31470	COG0228	four-way junction DNA binding
I1A49_RS31475	COG1837	Belongs to the UPF0109 family
I1A49_RS31480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I1A49_RS31485	COG0336	Belongs to the RNA methyltransferase TrmD family
I1A49_RS31490	COG0335	large ribosomal subunit rRNA binding
I1A49_RS31495	COG0681	Belongs to the peptidase S26 family
I1A49_RS31500	COG0681	Belongs to the peptidase S26 family
I1A49_RS31505	COG0681	Belongs to the peptidase S26 family
I1A49_RS31510	COG0681	Belongs to the peptidase S26 family
I1A49_RS31515	COG1051	belongs to the nudix hydrolase family
I1A49_RS31525	COG0792	nuclease activity
I1A49_RS31540	COG1191	sigma factor activity
I1A49_RS31555	COG0052	Belongs to the universal ribosomal protein uS2 family
I1A49_RS31560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I1A49_RS31565	COG0528	UMP kinase activity
I1A49_RS31570	COG0233	cytoplasmic translational termination
I1A49_RS31575	COG0575	Belongs to the CDS family
I1A49_RS31595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I1A49_RS31605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I1A49_RS31610	COG3842	ATPase activity
I1A49_RS31625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I1A49_RS31630	COG0028	Belongs to the TPP enzyme family
I1A49_RS31645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I1A49_RS31655	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS31670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I1A49_RS31680	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS31690	COG3842	ATPase activity
I1A49_RS31695	COG1176	ABC-type spermidine putrescine transport system, permease component I
I1A49_RS31700	COG1177	transmembrane transport
I1A49_RS31705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A49_RS31725	COG2508	Transcriptional regulator
I1A49_RS31730	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS31750	COG1609	Transcriptional regulator
I1A49_RS31760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I1A49_RS31765	COG0750	zinc metalloprotease
I1A49_RS31770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I1A49_RS31785	COG0442	prolyl-tRNA aminoacylation
I1A49_RS31805	COG0779	Required for maturation of 30S ribosomal subunits
I1A49_RS31820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I1A49_RS31830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I1A49_RS31835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I1A49_RS31865	COG1404	Belongs to the peptidase S8 family
I1A49_RS31890	COG1404	Belongs to the peptidase S8 family
I1A49_RS31915	COG1674	ftsk spoiiie
I1A49_RS31930	COG1404	Belongs to the peptidase S8 family
I1A49_RS31955	COG1674	ftsk spoiiie
I1A49_RS31980	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I1A49_RS31980	COG0515	serine threonine protein kinase
I1A49_RS31990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I1A49_RS31995	COG1185	polyribonucleotide nucleotidyltransferase activity
I1A49_RS32000	COG0612	Peptidase, M16
I1A49_RS32005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I1A49_RS32025	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I1A49_RS32030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS32035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I1A49_RS32065	COG2770	Histidine kinase
I1A49_RS32065	COG2208	phosphoserine phosphatase activity
I1A49_RS32080	COG1674	ftsk spoiiie
I1A49_RS32090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1A49_RS32100	COG1058	Belongs to the CinA family
I1A49_RS32100	COG1546	Belongs to the CinA family
I1A49_RS32105	COG1396	sequence-specific DNA binding
I1A49_RS32115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1A49_RS32120	COG1201	RNA secondary structure unwinding
I1A49_RS32175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A49_RS32190	COG0765	amino acid transport
I1A49_RS32195	COG0765	amino acid transport
I1A49_RS32200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I1A49_RS32205	COG1126	abc transporter atp-binding protein
I1A49_RS32210	COG0745	RESPONSE REGULATOR receiver
I1A49_RS32215	COG2205	protein histidine kinase activity
I1A49_RS32220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1A49_RS32230	COG1414	Transcriptional regulator
I1A49_RS32235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1A49_RS32250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I1A49_RS32260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I1A49_RS32265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1A49_RS32275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I1A49_RS32305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1A49_RS32310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I1A49_RS32315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1A49_RS32330	COG0488	(ABC) transporter
I1A49_RS32345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I1A49_RS32375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I1A49_RS32380	COG1802	Transcriptional regulator
I1A49_RS32385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1A49_RS32400	COG0187	DNA topoisomerase II activity
I1A49_RS32410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A49_RS32415	COG4565	transcriptional regulatory protein
I1A49_RS32420	COG3290	protein histidine kinase activity
I1A49_RS32435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1A49_RS32440	COG0612	Peptidase, M16
I1A49_RS32455	COG1802	Transcriptional regulator
I1A49_RS32460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A49_RS32465	COG1042	CoA-binding domain protein
I1A49_RS32465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A49_RS32465	COG0045	succinate-CoA ligase (ADP-forming) activity
I1A49_RS32480	COG1435	thymidine kinase activity
I1A49_RS32515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1A49_RS32520	COG0483	inositol monophosphate 1-phosphatase activity
I1A49_RS32530	COG0745	RESPONSE REGULATOR receiver
I1A49_RS32535	COG2205	protein histidine kinase activity
I1A49_RS32560	COG0756	dUTP diphosphatase activity
I1A49_RS32600	COG0569	domain protein
I1A49_RS32630	COG0531	amino acid
I1A49_RS32635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I1A49_RS32650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I1A49_RS32665	COG2124	cytochrome p450
I1A49_RS32680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1A49_RS32700	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I1A49_RS32735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS32740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS32745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS32770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS32775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1A49_RS32780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1A49_RS32785	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS32795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS32805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS32815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS32820	COG2124	cytochrome p450
I1A49_RS32845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS32865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1A49_RS32875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1A49_RS32890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1A49_RS32900	COG2409	Drug exporters of the RND superfamily
I1A49_RS32930	COG2040	homocysteine
I1A49_RS32935	COG4977	sequence-specific DNA binding
I1A49_RS32940	COG0477	Major facilitator Superfamily
I1A49_RS32965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I1A49_RS32980	COG3386	PFAM SMP-30 Gluconolaconase
I1A49_RS32985	COG0800	Aldolase
I1A49_RS32995	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS33005	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS33015	COG0395	ABC-type sugar transport system, permease component
I1A49_RS33020	COG1175	transmembrane transport
I1A49_RS33030	COG3345	alpha-galactosidase
I1A49_RS33040	COG3629	intracellular signal transduction
I1A49_RS33040	COG3903	Transcriptional regulator
I1A49_RS33085	COG1061	Type III restriction enzyme res subunit
I1A49_RS33090	COG1104	cysteine desulfurase activity
I1A49_RS33105	COG0519	Catalyzes the synthesis of GMP from XMP
I1A49_RS33155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1A49_RS33180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I1A49_RS33190	COG3537	Alpha-1,2-mannosidase
I1A49_RS33210	COG1653	transport
I1A49_RS33215	COG1175	transmembrane transport
I1A49_RS33220	COG0395	ABC-type sugar transport system, permease component
I1A49_RS33225	COG1940	carbohydrate kinase activity
I1A49_RS33230	COG4213	ABC transporter substrate-binding protein
I1A49_RS33240	COG4214	carbohydrate transport
I1A49_RS33245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I1A49_RS33250	COG0531	amino acid
I1A49_RS33265	COG1024	Enoyl-CoA hydratase
I1A49_RS33265	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS33270	COG0183	Belongs to the thiolase family
I1A49_RS33290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I1A49_RS33300	COG0446	pyridine nucleotide-disulphide oxidoreductase
I1A49_RS33305	COG2271	Major facilitator Superfamily
I1A49_RS33330	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I1A49_RS33335	COG3253	May function as heme-dependent peroxidase
I1A49_RS33355	COG3220	belongs to the UPF0276 family
I1A49_RS33360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A49_RS33405	COG0745	RESPONSE REGULATOR receiver
I1A49_RS33410	COG5002	protein histidine kinase activity
I1A49_RS33430	COG1136	(ABC) transporter
I1A49_RS33465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I1A49_RS33470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1A49_RS33590	COG1119	ATPase activity
I1A49_RS33615	COG1175	transmembrane transport
I1A49_RS33640	COG2409	Drug exporters of the RND superfamily
I1A49_RS33675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS33680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I1A49_RS33705	COG0529	Catalyzes the synthesis of activated sulfate
I1A49_RS33710	COG0175	sulfate reduction
I1A49_RS33750	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I1A49_RS33825	COG1162	GTPase activity
I1A49_RS33835	COG0583	DNA-binding transcription factor activity
I1A49_RS33845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A49_RS33855	COG0028	Belongs to the TPP enzyme family
I1A49_RS33875	COG1802	Transcriptional regulator
I1A49_RS33905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS33925	COG0823	Involved in the tonB-independent uptake of proteins
I1A49_RS33930	COG0598	Magnesium transport protein CorA
I1A49_RS33935	COG2197	response regulator
I1A49_RS33940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS33945	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS33970	COG2351	hydroxyisourate hydrolase activity
I1A49_RS33985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I1A49_RS33990	COG0746	molybdenum cofactor guanylyltransferase activity
I1A49_RS34000	COG1414	Transcriptional regulator
I1A49_RS34005	COG1953	Uracil, thiamine, allantoin
I1A49_RS34010	COG4266	Belongs to the allantoicase family
I1A49_RS34015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I1A49_RS34055	COG0800	Aldolase
I1A49_RS34075	COG2188	Transcriptional regulator
I1A49_RS34095	COG1940	carbohydrate kinase activity
I1A49_RS34105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A49_RS34130	COG1126	abc transporter atp-binding protein
I1A49_RS34135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A49_RS34140	COG0765	amino acid transport
I1A49_RS34145	COG0765	amino acid transport
I1A49_RS34180	COG0405	Gamma-glutamyltransferase
I1A49_RS34185	COG1335	isochorismatase
I1A49_RS34190	COG0477	Major facilitator Superfamily
I1A49_RS34210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1A49_RS34215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I1A49_RS34235	COG0483	inositol monophosphate 1-phosphatase activity
I1A49_RS34245	COG0181	hydroxymethylbilane synthase activity
I1A49_RS34280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1A49_RS34305	COG1929	Belongs to the glycerate kinase type-1 family
I1A49_RS34315	COG0688	phosphatidylethanolamine metabolic process
I1A49_RS34320	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS34330	COG2301	Belongs to the HpcH HpaI aldolase family
I1A49_RS34335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS34335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I1A49_RS34345	COG1309	transcriptional regulator
I1A49_RS34385	COG2362	D-Aminopeptidase
I1A49_RS34390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I1A49_RS34430	COG4106	trans-aconitate 2-methyltransferase activity
I1A49_RS34435	COG0617	tRNA 3'-terminal CCA addition
I1A49_RS34435	COG0517	IMP dehydrogenase activity
I1A49_RS34435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I1A49_RS34465	COG0693	protein deglycase activity
I1A49_RS34470	COG0028	Belongs to the TPP enzyme family
I1A49_RS34475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS34535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS34570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I1A49_RS34585	COG2267	carboxylic ester hydrolase activity
I1A49_RS34610	COG1879	ABC-type sugar transport system periplasmic component
I1A49_RS34620	COG4214	carbohydrate transport
I1A49_RS34645	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I1A49_RS34660	COG2154	pterin-4-alpha-carbinolamine dehydratase
I1A49_RS34675	COG1595	DNA-templated transcription, initiation
I1A49_RS34705	COG0583	DNA-binding transcription factor activity
I1A49_RS34725	COG0789	Transcriptional regulator
I1A49_RS34735	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS34745	COG1309	transcriptional regulator
I1A49_RS34750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I1A49_RS34765	COG3383	formate dehydrogenase (NAD+) activity
I1A49_RS34770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I1A49_RS34790	COG1940	carbohydrate kinase activity
I1A49_RS34795	COG1129	ABC transporter
I1A49_RS34800	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS34805	COG1879	ABC-type sugar transport system periplasmic component
I1A49_RS34810	COG0673	inositol 2-dehydrogenase activity
I1A49_RS34885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS34895	COG0045	succinate-CoA ligase (ADP-forming) activity
I1A49_RS34905	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS34935	COG1920	GTP binding
I1A49_RS34940	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I1A49_RS34945	COG2814	Major facilitator Superfamily
I1A49_RS34950	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I1A49_RS34955	COG2188	Transcriptional regulator
I1A49_RS34960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS34970	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS34985	COG1309	transcriptional regulator
I1A49_RS35005	COG0697	spore germination
I1A49_RS35010	COG1846	Transcriptional regulator
I1A49_RS35015	COG1414	Transcriptional regulator
I1A49_RS35020	COG1027	Aspartate ammonia-lyase
I1A49_RS35025	COG2271	Major facilitator Superfamily
I1A49_RS35055	COG0589	response to stress
I1A49_RS35060	COG2239	Acts as a magnesium transporter
I1A49_RS35070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I1A49_RS35080	COG0697	spore germination
I1A49_RS35085	COG0583	DNA-binding transcription factor activity
I1A49_RS35090	COG1609	Transcriptional regulator
I1A49_RS35110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I1A49_RS35115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1A49_RS35130	COG1309	transcriptional regulator
I1A49_RS35145	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I1A49_RS35150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I1A49_RS35155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I1A49_RS35240	COG0601	transmembrane transport
I1A49_RS35245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS35260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS35270	COG0431	NADPH-dependent FMN reductase
I1A49_RS35290	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS35355	COG0641	radical SAM
I1A49_RS35370	COG1515	deoxyribonuclease V activity
I1A49_RS35380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS35390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS35395	COG0183	Belongs to the thiolase family
I1A49_RS35400	COG1250	3-hydroxyacyl-CoA dehydrogenase
I1A49_RS35400	COG1024	Enoyl-CoA hydratase
I1A49_RS35405	COG0583	DNA-binding transcription factor activity
I1A49_RS35420	COG3250	beta-galactosidase activity
I1A49_RS35430	COG0308	aminopeptidase N
I1A49_RS35435	COG2936	dipeptidyl-peptidase activity
I1A49_RS35445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I1A49_RS35480	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I1A49_RS35525	COG1134	teichoic acid transport
I1A49_RS35540	COG1562	ergosterol biosynthetic process
I1A49_RS35550	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I1A49_RS35560	COG1657	PFAM Prenyltransferase squalene oxidase
I1A49_RS35580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I1A49_RS35595	COG2365	Tyrosine phosphatase family
I1A49_RS35600	COG2755	lipolytic protein G-D-S-L family
I1A49_RS35625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1A49_RS35675	COG0596	Alpha beta hydrolase
I1A49_RS35680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I1A49_RS35685	COG0531	amino acid
I1A49_RS35700	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS35740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1A49_RS35750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I1A49_RS35755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I1A49_RS35760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I1A49_RS35765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1A49_RS35770	COG5002	protein histidine kinase activity
I1A49_RS35775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I1A49_RS35780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A49_RS35780	COG0072	phenylalanine-tRNA ligase activity
I1A49_RS35795	COG2860	membrane
I1A49_RS35815	COG1285	pathogenesis
I1A49_RS35820	COG2814	Major facilitator Superfamily
I1A49_RS35840	COG1649	PFAM Uncharacterised BCR, COG1649
I1A49_RS35850	COG0697	spore germination
I1A49_RS35855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A49_RS35870	COG2838	Isocitrate dehydrogenase
I1A49_RS35875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I1A49_RS35880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I1A49_RS35885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I1A49_RS35890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1A49_RS35895	COG1438	arginine binding
I1A49_RS35900	COG0385	Bile acid
I1A49_RS35905	COG0583	DNA-binding transcription factor activity
I1A49_RS35945	COG0137	argininosuccinate synthase activity
I1A49_RS35950	COG0165	Argininosuccinate lyase
I1A49_RS35965	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS35965	COG0204	Acyl-transferase
I1A49_RS36005	COG2011	ABC-type metal ion transport system permease component
I1A49_RS36010	COG1464	Belongs to the NlpA lipoprotein family
I1A49_RS36025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I1A49_RS36030	COG1648	precorrin-2 dehydrogenase activity
I1A49_RS36030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I1A49_RS36075	COG1733	regulation of RNA biosynthetic process
I1A49_RS36130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1A49_RS36130	COG0512	Glutamine amidotransferase of anthranilate synthase
I1A49_RS36200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I1A49_RS36215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1A49_RS36235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I1A49_RS36245	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS36255	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I1A49_RS36260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I1A49_RS36265	COG0217	transcriptional regulatory protein
I1A49_RS36270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I1A49_RS36275	COG0632	four-way junction helicase activity
I1A49_RS36280	COG2255	four-way junction helicase activity
I1A49_RS36290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1A49_RS36295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1A49_RS36300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1A49_RS36305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1A49_RS36310	COG1196	nuclear chromosome segregation
I1A49_RS36315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1A49_RS36325	COG0124	histidyl-tRNA synthetase
I1A49_RS36330	COG2197	response regulator
I1A49_RS36335	COG4585	Histidine kinase
I1A49_RS36365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I1A49_RS36380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I1A49_RS36385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I1A49_RS36395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I1A49_RS36400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I1A49_RS36405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I1A49_RS36410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I1A49_RS36420	COG0006	proline dipeptidase activity
I1A49_RS36425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I1A49_RS36430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1A49_RS36440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I1A49_RS36445	COG0540	Belongs to the ATCase OTCase family
I1A49_RS36450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I1A49_RS36460	COG0505	Belongs to the CarA family
I1A49_RS36465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I1A49_RS36470	COG0167	dihydroorotate dehydrogenase activity
I1A49_RS36475	COG0284	orotidine-5'-phosphate decarboxylase activity
I1A49_RS36485	COG0194	GDP metabolic process
I1A49_RS36500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I1A49_RS36515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I1A49_RS36520	COG1132	(ABC) transporter
I1A49_RS36535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I1A49_RS36540	COG2390	Transcriptional regulator
I1A49_RS36545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I1A49_RS36555	COG0640	Transcriptional regulator
I1A49_RS36590	COG0531	amino acid
I1A49_RS36600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A49_RS36625	COG2233	PERMEase
I1A49_RS36635	COG0738	Major facilitator superfamily
I1A49_RS36660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A49_RS36660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1A49_RS36665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I1A49_RS36670	COG0140	phosphoribosyl-ATP diphosphatase activity
I1A49_RS36675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I1A49_RS36720	COG5001	Diguanylate cyclase
I1A49_RS36720	COG3300	MHYT domain
I1A49_RS36730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A49_RS36745	COG0473	3-isopropylmalate dehydrogenase activity
I1A49_RS36750	COG0066	3-isopropylmalate dehydratase activity
I1A49_RS36760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A49_RS36780	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS36790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS36790	COG3320	Male sterility
I1A49_RS36815	COG1132	(ABC) transporter
I1A49_RS36820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS36830	COG1131	(ABC) transporter
I1A49_RS36850	COG3251	PFAM MbtH domain protein
I1A49_RS36855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS36865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS36875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS36880	COG4585	Histidine kinase
I1A49_RS36895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A49_RS36910	COG3483	tryptophan 2,3-dioxygenase activity
I1A49_RS36920	COG0475	glutathione-regulated potassium exporter activity
I1A49_RS36930	COG1051	belongs to the nudix hydrolase family
I1A49_RS36955	COG2226	methyltransferase
I1A49_RS36965	COG0667	Aldo Keto reductase
I1A49_RS36980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I1A49_RS36985	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
I1A49_RS37000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I1A49_RS37005	COG0494	nUDIX hydrolase
I1A49_RS37010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I1A49_RS37025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I1A49_RS37040	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS37055	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS37080	COG0463	Glycosyl transferase, family 2
I1A49_RS37110	COG2186	Transcriptional regulator
I1A49_RS37175	COG1556	Lactate utilization protein
I1A49_RS37180	COG1139	Iron-sulfur cluster binding protein
I1A49_RS37185	COG0247	lactate metabolic process
I1A49_RS37190	COG1070	Carbohydrate kinase
I1A49_RS37195	COG3347	Dehydrogenase
I1A49_RS37195	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS37205	COG3250	beta-galactosidase activity
I1A49_RS37230	COG3254	rhamnose metabolic process
I1A49_RS37240	COG1609	Transcriptional regulator
I1A49_RS37245	COG1609	Transcriptional regulator
I1A49_RS37250	COG2072	flavoprotein involved in K transport
I1A49_RS37275	COG0596	Alpha beta hydrolase
I1A49_RS37285	COG2264	protein methyltransferase activity
I1A49_RS37295	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I1A49_RS37300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A49_RS37330	COG1175	transmembrane transport
I1A49_RS37335	COG0395	ABC-type sugar transport system, permease component
I1A49_RS37345	COG1874	Beta-galactosidase
I1A49_RS37365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS37430	COG0604	alcohol dehydrogenase
I1A49_RS37550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A49_RS37570	COG0642	Histidine kinase
I1A49_RS37575	COG2018	Roadblock/LC7 domain
I1A49_RS37600	COG0395	ABC-type sugar transport system, permease component
I1A49_RS37605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS37615	COG0583	DNA-binding transcription factor activity
I1A49_RS37660	COG4565	transcriptional regulatory protein
I1A49_RS37665	COG3290	protein histidine kinase activity
I1A49_RS37680	COG1609	Transcriptional regulator
I1A49_RS37685	COG0395	ABC-type sugar transport system, permease component
I1A49_RS37690	COG1175	transmembrane transport
I1A49_RS37705	COG1070	Carbohydrate kinase
I1A49_RS37720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A49_RS37730	COG1968	undecaprenyl-diphosphatase activity
I1A49_RS37735	COG2814	Major facilitator Superfamily
I1A49_RS37750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I1A49_RS37815	COG1832	CoA-binding protein
I1A49_RS37825	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS37830	COG1335	isochorismatase
I1A49_RS37835	COG2267	carboxylic ester hydrolase activity
I1A49_RS37840	COG2066	Belongs to the glutaminase family
I1A49_RS37880	COG0028	Belongs to the TPP enzyme family
I1A49_RS37885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A49_RS37910	COG0667	Aldo Keto reductase
I1A49_RS37925	COG2814	Major facilitator Superfamily
I1A49_RS37935	COG1739	Uncharacterized protein family UPF0029
I1A49_RS37945	COG0420	3'-5' exonuclease activity
I1A49_RS37970	COG0626	cystathionine gamma-synthase activity
I1A49_RS38000	COG2188	Transcriptional regulator
I1A49_RS38005	COG1940	carbohydrate kinase activity
I1A49_RS38015	COG0009	L-threonylcarbamoyladenylate synthase
I1A49_RS38025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I1A49_RS38065	COG0577	efflux transmembrane transporter activity
I1A49_RS38065	COG1136	(ABC) transporter
I1A49_RS38070	COG2226	methyltransferase
I1A49_RS38075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I1A49_RS38080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I1A49_RS38090	COG0156	8-amino-7-oxononanoate synthase activity
I1A49_RS38120	COG0741	lytic transglycosylase activity
I1A49_RS38120	COG0791	NLP P60 protein
I1A49_RS38130	COG0740	serine-type endopeptidase activity
I1A49_RS38140	COG4935	Belongs to the peptidase S8 family
I1A49_RS38140	COG2234	aminopeptidase activity
I1A49_RS38145	COG0831	urea catabolic process
I1A49_RS38150	COG0832	Belongs to the urease beta subunit family
I1A49_RS38155	COG0804	urea catabolic process
I1A49_RS38165	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I1A49_RS38170	COG0829	nickel cation binding
I1A49_RS38220	COG0205	6-phosphofructokinase activity
I1A49_RS38225	COG3442	glutamine amidotransferase
I1A49_RS38235	COG0242	peptide deformylase activity
I1A49_RS38245	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS38250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1A49_RS38280	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS38295	COG0702	epimerase
I1A49_RS38300	COG3631	Ketosteroid isomerase-related protein
I1A49_RS38320	COG0252	asparaginase activity
I1A49_RS38335	COG1793	dna ligase
I1A49_RS38345	COG1191	sigma factor activity
I1A49_RS38360	COG1132	(ABC) transporter
I1A49_RS38365	COG1132	(ABC) transporter
I1A49_RS38370	COG1349	DNA-binding transcription factor activity
I1A49_RS38375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I1A49_RS38380	COG3395	kinase activity
I1A49_RS38385	COG0667	Aldo Keto reductase
I1A49_RS38395	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS38455	COG3629	intracellular signal transduction
I1A49_RS38455	COG3903	Transcriptional regulator
I1A49_RS38480	COG0395	ABC-type sugar transport system, permease component
I1A49_RS38485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1A49_RS38495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS38520	COG0242	peptide deformylase activity
I1A49_RS38535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1A49_RS38545	COG3250	beta-galactosidase activity
I1A49_RS38585	COG1063	alcohol dehydrogenase
I1A49_RS38610	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I1A49_RS38615	COG0277	FAD linked oxidase domain protein
I1A49_RS38620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1A49_RS38625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1A49_RS38685	COG0640	Transcriptional regulator
I1A49_RS38705	COG1126	abc transporter atp-binding protein
I1A49_RS38710	COG0765	amino acid transport
I1A49_RS38755	COG2186	Transcriptional regulator
I1A49_RS38780	COG0514	ATP-dependent DNA helicase (RecQ)
I1A49_RS38800	COG1063	alcohol dehydrogenase
I1A49_RS38805	COG0395	ABC-type sugar transport system, permease component
I1A49_RS38815	COG1653	transport
I1A49_RS38825	COG1486	melibiose metabolic process
I1A49_RS38835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS38840	COG1653	transport
I1A49_RS38845	COG1175	transmembrane transport
I1A49_RS38850	COG0395	ABC-type sugar transport system, permease component
I1A49_RS38925	COG2353	YceI-like domain
I1A49_RS38935	COG0386	Belongs to the glutathione peroxidase family
I1A49_RS38945	COG1595	DNA-templated transcription, initiation
I1A49_RS38955	COG2197	response regulator
I1A49_RS38990	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I1A49_RS39000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS39005	COG0583	DNA-binding transcription factor activity
I1A49_RS39010	COG2851	Citrate transporter
I1A49_RS39020	COG1064	alcohol dehydrogenase
I1A49_RS39025	COG3537	Alpha-1,2-mannosidase
I1A49_RS39040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I1A49_RS39050	COG0174	glutamine synthetase
I1A49_RS39055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I1A49_RS39065	COG2133	pyrroloquinoline quinone binding
I1A49_RS39075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I1A49_RS39080	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I1A49_RS39100	COG0438	transferase activity, transferring glycosyl groups
I1A49_RS39105	COG0745	RESPONSE REGULATOR receiver
I1A49_RS39135	COG0477	Major facilitator Superfamily
I1A49_RS39140	COG1733	regulation of RNA biosynthetic process
I1A49_RS39145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I1A49_RS39155	COG0671	phosphoesterase, PA-phosphatase related
I1A49_RS39210	COG0110	maltose O-acetyltransferase activity
I1A49_RS39225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I1A49_RS39265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1A49_RS39295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I1A49_RS39370	COG1131	(ABC) transporter
I1A49_RS39380	COG4585	Histidine kinase
I1A49_RS39385	COG2197	response regulator
I1A49_RS39395	COG0667	Aldo Keto reductase
I1A49_RS39415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1A49_RS39425	COG1252	NADH dehydrogenase
I1A49_RS39430	COG3959	Transketolase, thiamine diphosphate binding domain
I1A49_RS39445	COG3360	Dodecin
I1A49_RS39455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I1A49_RS39475	COG1024	Enoyl-CoA hydratase
I1A49_RS39480	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS39500	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS39505	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS39515	COG0183	Belongs to the thiolase family
I1A49_RS39555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1A49_RS39570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1A49_RS39580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A49_RS39590	COG0745	RESPONSE REGULATOR receiver
I1A49_RS39640	COG0191	fructose-bisphosphate aldolase activity
I1A49_RS39645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1A49_RS39650	COG1349	DNA-binding transcription factor activity
I1A49_RS39655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I1A49_RS39685	COG2182	Extracellular solute-binding protein
I1A49_RS39690	COG1175	transmembrane transport
I1A49_RS39695	COG0395	ABC-type sugar transport system, permease component
I1A49_RS39700	COG2723	6-phospho-beta-galactosidase activity
I1A49_RS39725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I1A49_RS39725	COG1796	DNA polymerase
I1A49_RS39735	COG3250	beta-galactosidase activity
I1A49_RS39760	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS39780	COG1802	Transcriptional regulator
I1A49_RS39785	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS39790	COG0596	Alpha beta hydrolase
I1A49_RS39805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS39810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A49_RS39820	COG1522	sequence-specific DNA binding
I1A49_RS39850	COG0443	Heat shock 70 kDa protein
I1A49_RS39865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I1A49_RS39870	COG0477	Major facilitator Superfamily
I1A49_RS39900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1A49_RS39905	COG1834	amidinotransferase
I1A49_RS39930	COG0673	inositol 2-dehydrogenase activity
I1A49_RS39940	COG3290	protein histidine kinase activity
I1A49_RS39980	COG1522	sequence-specific DNA binding
I1A49_RS39980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS39985	COG2313	pseudouridylate synthase activity
I1A49_RS39990	COG0384	phenazine biosynthesis protein PhzF
I1A49_RS40015	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS40020	COG1252	NADH dehydrogenase
I1A49_RS40025	COG1595	DNA-templated transcription, initiation
I1A49_RS40035	COG0542	response to heat
I1A49_RS40045	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A49_RS40050	COG2936	dipeptidyl-peptidase activity
I1A49_RS40060	COG3629	intracellular signal transduction
I1A49_RS40080	COG3321	synthase
I1A49_RS40080	COG0604	alcohol dehydrogenase
I1A49_RS40085	COG0604	alcohol dehydrogenase
I1A49_RS40085	COG3321	synthase
I1A49_RS40090	COG3321	synthase
I1A49_RS40090	COG0604	alcohol dehydrogenase
I1A49_RS40160	COG3415	Transposase
I1A49_RS40160	COG2801	Transposase and inactivated derivatives
I1A49_RS40170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS40265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS40270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I1A49_RS40275	COG2080	2 iron, 2 sulfur cluster binding
I1A49_RS40290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I1A49_RS40300	COG2226	methyltransferase
I1A49_RS40340	COG0477	Major facilitator Superfamily
I1A49_RS40360	COG3012	SEC-C Motif Domain Protein
I1A49_RS40365	COG1063	alcohol dehydrogenase
I1A49_RS40370	COG2271	Major facilitator Superfamily
I1A49_RS40495	COG0464	growth
I1A49_RS40530	COG0437	4 iron, 4 sulfur cluster binding
I1A49_RS40535	COG0243	molybdopterin cofactor binding
I1A49_RS40535	COG3383	formate dehydrogenase (NAD+) activity
I1A49_RS40580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A49_RS40620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I1A49_RS40630	COG2340	Cysteine-rich secretory protein family
I1A49_RS40645	COG0531	amino acid
I1A49_RS40655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1A49_RS40680	COG3290	protein histidine kinase activity
I1A49_RS40710	COG1024	Enoyl-CoA hydratase
I1A49_RS40770	COG2205	protein histidine kinase activity
I1A49_RS40775	COG0745	RESPONSE REGULATOR receiver
I1A49_RS40780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1A49_RS40780	COG1017	nitric oxide dioxygenase activity
I1A49_RS40795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1A49_RS40805	COG2326	polyphosphate kinase activity
I1A49_RS40815	COG0309	Hydrogenase expression formation protein (HypE)
I1A49_RS40825	COG0298	carbon dioxide binding
I1A49_RS40830	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I1A49_RS40865	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS40870	COG1309	transcriptional regulator
I1A49_RS40875	COG2188	Transcriptional regulator
I1A49_RS40880	COG3573	Dehydrogenase
I1A49_RS40890	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I1A49_RS40900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1A49_RS40905	COG3572	ergothioneine biosynthetic process
I1A49_RS40915	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS40920	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS40930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1A49_RS40935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1A49_RS40950	COG1940	carbohydrate kinase activity
I1A49_RS40955	COG1070	Carbohydrate kinase
I1A49_RS40965	COG4677	pectinesterase activity
I1A49_RS40975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1A49_RS41015	COG2018	Roadblock/LC7 domain
I1A49_RS41025	COG1946	Acyl-CoA thioesterase
I1A49_RS41040	COG1132	(ABC) transporter
I1A49_RS41045	COG1132	(ABC) transporter
I1A49_RS41060	COG1132	(ABC) transporter
I1A49_RS41065	COG3629	intracellular signal transduction
I1A49_RS41170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1A49_RS41205	COG0604	alcohol dehydrogenase
I1A49_RS41205	COG3321	synthase
I1A49_RS41230	COG0604	alcohol dehydrogenase
I1A49_RS41230	COG3321	synthase
I1A49_RS41235	COG0604	alcohol dehydrogenase
I1A49_RS41235	COG3321	synthase
I1A49_RS41255	COG1733	regulation of RNA biosynthetic process
I1A49_RS41275	COG2391	methyltransferase activity
I1A49_RS41280	COG3226	Transcriptional regulator
I1A49_RS41290	COG2186	Transcriptional regulator
I1A49_RS41295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A49_RS41300	COG1113	amino acid transport
I1A49_RS41305	COG2207	Transcriptional regulator
I1A49_RS41305	COG3708	Transcriptional regulator
I1A49_RS41325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS41330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I1A49_RS41335	COG2080	2 iron, 2 sulfur cluster binding
I1A49_RS41345	COG0673	inositol 2-dehydrogenase activity
I1A49_RS41350	COG0673	inositol 2-dehydrogenase activity
I1A49_RS41355	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS41385	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS41390	COG0444	Belongs to the ABC transporter superfamily
I1A49_RS41395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS41400	COG0601	transmembrane transport
I1A49_RS41405	COG4166	transmembrane transport
I1A49_RS41415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1A49_RS41440	COG0596	Alpha beta hydrolase
I1A49_RS41445	COG2188	Transcriptional regulator
I1A49_RS41450	COG1397	ADP-ribosylglycohydrolase
I1A49_RS41460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A49_RS41470	COG4221	oxidoreductase activity
I1A49_RS41500	COG0367	asparagine synthase
I1A49_RS41515	COG0673	inositol 2-dehydrogenase activity
I1A49_RS41530	COG1280	lysine exporter protein (LysE YggA)
I1A49_RS41580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS41615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS41625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS41645	COG2423	ornithine cyclodeaminase activity
I1A49_RS41650	COG2197	response regulator
I1A49_RS41655	COG4585	Histidine kinase
I1A49_RS41660	COG0586	Pfam SNARE associated Golgi protein
I1A49_RS41670	COG0765	amino acid transport
I1A49_RS41675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A49_RS41700	COG0667	Aldo Keto reductase
I1A49_RS41720	COG0667	Aldo Keto reductase
I1A49_RS41725	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS41730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1A49_RS41745	COG2814	Major facilitator Superfamily
I1A49_RS41760	COG0673	inositol 2-dehydrogenase activity
I1A49_RS41775	COG1796	DNA polymerase
I1A49_RS41775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I1A49_RS41800	COG0697	spore germination
I1A49_RS41820	COG0574	Belongs to the PEP-utilizing enzyme family
I1A49_RS41820	COG3848	Pyruvate phosphate dikinase
I1A49_RS41825	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS41860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I1A49_RS41865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A49_RS41870	COG4585	Histidine kinase
I1A49_RS41880	COG1454	alcohol dehydrogenase
I1A49_RS41890	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS41895	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS41900	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I1A49_RS41915	COG0477	Major facilitator Superfamily
I1A49_RS41960	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I1A49_RS41965	COG1024	Enoyl-CoA hydratase
I1A49_RS41970	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS41975	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS41985	COG0583	DNA-binding transcription factor activity
I1A49_RS41995	COG1940	carbohydrate kinase activity
I1A49_RS41995	COG1846	Transcriptional regulator
I1A49_RS42000	COG3345	alpha-galactosidase
I1A49_RS42015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A49_RS42015	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I1A49_RS42025	COG1176	ABC-type spermidine putrescine transport system, permease component I
I1A49_RS42030	COG3842	ATPase activity
I1A49_RS42165	COG0154	amidase activity
I1A49_RS42170	COG2050	protein possibly involved in aromatic compounds catabolism
I1A49_RS42200	COG0745	RESPONSE REGULATOR receiver
I1A49_RS42205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I1A49_RS42210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS42250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A49_RS42265	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS42275	COG3226	Transcriptional regulator
I1A49_RS42280	COG0738	Major facilitator superfamily
I1A49_RS42300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A49_RS42345	COG0475	glutathione-regulated potassium exporter activity
I1A49_RS42360	COG0583	DNA-binding transcription factor activity
I1A49_RS42365	COG0604	alcohol dehydrogenase
I1A49_RS42365	COG3321	synthase
I1A49_RS42390	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS42395	COG0444	Belongs to the ABC transporter superfamily
I1A49_RS42400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS42405	COG0601	transmembrane transport
I1A49_RS42440	COG2130	NADP-dependent
I1A49_RS42450	COG1309	transcriptional regulator
I1A49_RS42455	COG3424	synthase
I1A49_RS42575	COG1024	Enoyl-CoA hydratase
I1A49_RS42580	COG1024	Enoyl-CoA hydratase
I1A49_RS42610	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I1A49_RS42630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS42645	COG2175	clavaminate synthase activity
I1A49_RS42680	COG0165	Argininosuccinate lyase
I1A49_RS42690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A49_RS42695	COG2197	response regulator
I1A49_RS42700	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS42705	COG1309	transcriptional regulator
I1A49_RS42720	COG2267	carboxylic ester hydrolase activity
I1A49_RS42730	COG4221	oxidoreductase activity
I1A49_RS42740	COG1063	alcohol dehydrogenase
I1A49_RS42745	COG0667	Aldo Keto reductase
I1A49_RS42760	COG2315	Protein conserved in bacteria
I1A49_RS42790	COG2186	Transcriptional regulator
I1A49_RS42800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1A49_RS42815	COG3842	ATPase activity
I1A49_RS42820	COG1178	ABC-type Fe3 transport system permease component
I1A49_RS42825	COG1840	ABC-type Fe3 transport system, periplasmic component
I1A49_RS42845	COG0588	phosphoglycerate mutase activity
I1A49_RS42865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I1A49_RS42875	COG0698	ribose 5-phosphate isomerase
I1A49_RS42890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I1A49_RS42895	COG2159	amidohydrolase
I1A49_RS42905	COG0583	DNA-binding transcription factor activity
I1A49_RS42920	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I1A49_RS42925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS42930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS42935	COG1120	ATPase activity
I1A49_RS42940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I1A49_RS42945	COG1132	(ABC) transporter
I1A49_RS42955	COG1132	(ABC) transporter
I1A49_RS42960	COG2382	esterase
I1A49_RS42995	COG1017	nitric oxide dioxygenase activity
I1A49_RS42995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1A49_RS43010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I1A49_RS43015	COG1140	nitrate reductase beta subunit
I1A49_RS43025	COG1309	transcriptional regulator
I1A49_RS43055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS43065	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS43080	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS43085	COG0444	Belongs to the ABC transporter superfamily
I1A49_RS43090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS43105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I1A49_RS43110	COG1349	DNA-binding transcription factor activity
I1A49_RS43150	COG0154	amidase activity
I1A49_RS43155	COG1309	transcriptional regulator
I1A49_RS43180	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS43185	COG0657	acetylesterase activity
I1A49_RS43205	COG1879	ABC-type sugar transport system periplasmic component
I1A49_RS43210	COG1063	alcohol dehydrogenase
I1A49_RS43215	COG1069	ribulokinase activity
I1A49_RS43225	COG1129	ABC transporter
I1A49_RS43230	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS43235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I1A49_RS43240	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS43245	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS43250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1A49_RS43295	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS43300	COG1309	transcriptional regulator
I1A49_RS43320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I1A49_RS43325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I1A49_RS43335	COG0436	Aminotransferase
I1A49_RS43340	COG0477	Major facilitator Superfamily
I1A49_RS43350	COG0656	L-ascorbic acid biosynthetic process
I1A49_RS43355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A49_RS43360	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS43370	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS43375	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS43380	COG1063	alcohol dehydrogenase
I1A49_RS43385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I1A49_RS43390	COG2084	Dehydrogenase
I1A49_RS43415	COG1175	transmembrane transport
I1A49_RS43420	COG0395	ABC-type sugar transport system, permease component
I1A49_RS43425	COG2186	Transcriptional regulator
I1A49_RS43430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS43435	COG1116	anion transmembrane transporter activity
I1A49_RS43440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1A49_RS43460	COG3250	beta-galactosidase activity
I1A49_RS43470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A49_RS43480	COG1891	lyase activity
I1A49_RS43485	COG0456	acetyltransferase
I1A49_RS43510	COG1595	DNA-templated transcription, initiation
I1A49_RS43520	COG4221	oxidoreductase activity
I1A49_RS43525	COG2801	Transposase and inactivated derivatives
I1A49_RS43525	COG3415	Transposase
I1A49_RS43540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I1A49_RS43560	COG1595	DNA-templated transcription, initiation
I1A49_RS43590	COG3260	NADH ubiquinone oxidoreductase 20
I1A49_RS43600	COG0650	Formate hydrogenlyase subunit 4
I1A49_RS43610	COG0651	ATP synthesis coupled electron transport
I1A49_RS43615	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I1A49_RS43615	COG3261	NADH dehydrogenase
I1A49_RS43625	COG0477	Major facilitator Superfamily
I1A49_RS43635	COG0028	Belongs to the TPP enzyme family
I1A49_RS43640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I1A49_RS43645	COG2188	Transcriptional regulator
I1A49_RS43650	COG1070	Carbohydrate kinase
I1A49_RS43675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS43680	COG3938	Belongs to the proline racemase family
I1A49_RS43690	COG0395	ABC-type sugar transport system, permease component
I1A49_RS43695	COG1175	transmembrane transport
I1A49_RS43705	COG1609	Transcriptional regulator
I1A49_RS43715	COG1129	ABC transporter
I1A49_RS43720	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS43735	COG1228	amidohydrolase
I1A49_RS43745	COG1802	Transcriptional regulator
I1A49_RS43760	COG0583	DNA-binding transcription factor activity
I1A49_RS43785	COG5002	protein histidine kinase activity
I1A49_RS43795	COG1136	(ABC) transporter
I1A49_RS43800	COG1136	(ABC) transporter
I1A49_RS43810	COG0745	RESPONSE REGULATOR receiver
I1A49_RS43815	COG0583	DNA-binding transcription factor activity
I1A49_RS43820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS43830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS43840	COG1116	anion transmembrane transporter activity
I1A49_RS43855	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS43860	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS43865	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS43875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS43880	COG0601	transmembrane transport
I1A49_RS43885	COG0747	negative chemotaxis
I1A49_RS43920	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS43940	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS44010	COG0402	S-adenosylhomocysteine deaminase activity
I1A49_RS44015	COG0277	FAD linked oxidase domain protein
I1A49_RS44030	COG1309	transcriptional regulator
I1A49_RS44035	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS44045	COG1914	H( )-stimulated, divalent metal cation uptake system
I1A49_RS44060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A49_RS44080	COG1802	Transcriptional regulator
I1A49_RS44105	COG0765	amino acid transport
I1A49_RS44115	COG2186	Transcriptional regulator
I1A49_RS44140	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS44145	COG1129	ABC transporter
I1A49_RS44160	COG0434	BtpA family
I1A49_RS44165	COG1609	Transcriptional regulator
I1A49_RS44205	COG2124	cytochrome p450
I1A49_RS44235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1A49_RS44250	COG2423	ornithine cyclodeaminase activity
I1A49_RS44260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1A49_RS44265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1A49_RS44270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS44275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS44280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1A49_RS44320	COG2318	DinB family
I1A49_RS44340	COG1653	transport
I1A49_RS44365	COG0667	Aldo Keto reductase
I1A49_RS44425	COG1175	transmembrane transport
I1A49_RS44430	COG0395	ABC-type sugar transport system, permease component
I1A49_RS44435	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
I1A49_RS44440	COG5492	domain, Protein
I1A49_RS44450	COG0275	rRNA processing
I1A49_RS44455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A49_RS44460	COG1120	ATPase activity
I1A49_RS44470	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1A49_RS44480	COG1121	(ABC) transporter
I1A49_RS44525	COG0583	DNA-binding transcription factor activity
I1A49_RS44530	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS44550	COG1733	regulation of RNA biosynthetic process
I1A49_RS44565	COG3321	synthase
I1A49_RS44565	COG0604	alcohol dehydrogenase
I1A49_RS44565	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS44580	COG0667	Aldo Keto reductase
I1A49_RS44585	COG2207	Transcriptional regulator
I1A49_RS44590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I1A49_RS44600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I1A49_RS44645	COG1129	ABC transporter
I1A49_RS44650	COG1172	Belongs to the binding-protein-dependent transport system permease family
I1A49_RS44655	COG0657	acetylesterase activity
I1A49_RS44665	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I1A49_RS44715	COG1595	DNA-templated transcription, initiation
I1A49_RS44735	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1A49_RS44735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS44750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A49_RS44760	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I1A49_RS44825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A49_RS44840	COG1414	Transcriptional regulator
I1A49_RS44855	COG4221	oxidoreductase activity
I1A49_RS44880	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS44885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS44900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1A49_RS44925	COG1129	ABC transporter
I1A49_RS44930	COG4214	carbohydrate transport
I1A49_RS44935	COG0583	DNA-binding transcription factor activity
I1A49_RS44955	COG0154	amidase activity
I1A49_RS44980	COG1653	transport
I1A49_RS44990	COG1609	Transcriptional regulator
I1A49_RS45000	COG3511	phospholipase C
I1A49_RS45005	COG3511	phospholipase C
I1A49_RS45015	COG2188	Transcriptional regulator
I1A49_RS45025	COG1176	ABC-type spermidine putrescine transport system, permease component I
I1A49_RS45035	COG3842	ATPase activity
I1A49_RS45050	COG0494	nUDIX hydrolase
I1A49_RS45050	COG0406	alpha-ribazole phosphatase activity
I1A49_RS45085	COG0604	alcohol dehydrogenase
I1A49_RS45105	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS45115	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS45125	COG0179	Fumarylacetoacetate (FAA) hydrolase
I1A49_RS45130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS45130	COG3321	synthase
I1A49_RS45130	COG4221	oxidoreductase activity
I1A49_RS45130	COG0604	alcohol dehydrogenase
I1A49_RS45140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS45150	COG0730	response to heat
I1A49_RS45160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A49_RS45170	COG2890	protein-(glutamine-N5) methyltransferase activity
I1A49_RS45175	COG0492	ferredoxin-NADP+ reductase activity
I1A49_RS45185	COG2249	NAD(P)H dehydrogenase (quinone) activity
I1A49_RS45195	COG1309	transcriptional regulator
I1A49_RS45200	COG1960	acyl-CoA dehydrogenase activity
I1A49_RS45205	COG0747	negative chemotaxis
I1A49_RS45210	COG0601	transmembrane transport
I1A49_RS45215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS45230	COG2267	carboxylic ester hydrolase activity
I1A49_RS45255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A49_RS45255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I1A49_RS45270	COG0714	Associated with various cellular activities
I1A49_RS45295	COG0251	oxidation-reduction process
I1A49_RS45300	COG2423	ornithine cyclodeaminase activity
I1A49_RS45305	COG3321	synthase
I1A49_RS45305	COG0604	alcohol dehydrogenase
I1A49_RS45305	COG3321	synthase
I1A49_RS45305	COG0604	alcohol dehydrogenase
I1A49_RS45315	COG0604	alcohol dehydrogenase
I1A49_RS45315	COG3321	synthase
I1A49_RS45315	COG0604	alcohol dehydrogenase
I1A49_RS45315	COG3321	synthase
I1A49_RS45330	COG0436	Aminotransferase
I1A49_RS45335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1A49_RS45340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I1A49_RS45360	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS45375	COG3629	intracellular signal transduction
I1A49_RS45375	COG3903	Transcriptional regulator
I1A49_RS45380	COG0367	asparagine synthase
I1A49_RS45395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A49_RS45415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1A49_RS45425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1A49_RS45450	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS45455	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I1A49_RS45480	COG0596	Alpha beta hydrolase
I1A49_RS45495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A49_RS45505	COG1902	pentaerythritol trinitrate reductase activity
I1A49_RS45535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A49_RS45555	COG0066	3-isopropylmalate dehydratase activity
I1A49_RS45560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1A49_RS45570	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS45575	COG4948	Mandelate Racemase Muconate Lactonizing
I1A49_RS45630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1A49_RS45635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I1A49_RS45640	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I1A49_RS45645	COG2080	2 iron, 2 sulfur cluster binding
I1A49_RS45655	COG0300	oxidoreductase activity
I1A49_RS45690	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I1A49_RS45705	COG1309	transcriptional regulator
I1A49_RS45795	COG1733	regulation of RNA biosynthetic process
I1A49_RS45800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I1A49_RS45840	COG0778	Nitroreductase
I1A49_RS45855	COG0667	Aldo Keto reductase
I1A49_RS45860	COG0667	Aldo Keto reductase
I1A49_RS45865	COG2271	Major facilitator Superfamily
I1A49_RS45870	COG0747	negative chemotaxis
I1A49_RS45880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS45905	COG2755	lipolytic protein G-D-S-L family
I1A49_RS45955	COG1309	transcriptional regulator
I1A49_RS45975	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I1A49_RS45980	COG2146	nitrite reductase [NAD(P)H] activity
I1A49_RS45990	COG2267	carboxylic ester hydrolase activity
I1A49_RS46015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I1A49_RS46025	COG0477	Major facilitator Superfamily
I1A49_RS46040	COG1840	ABC-type Fe3 transport system, periplasmic component
I1A49_RS46060	COG0667	Aldo Keto reductase
I1A49_RS46070	COG2910	NAD(P)H-binding
I1A49_RS46085	COG0436	Aminotransferase
I1A49_RS46140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1A49_RS46170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I1A49_RS46175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I1A49_RS46185	COG3547	Transposase (IS116 IS110 IS902 family)
I1A49_RS46205	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS46210	COG1846	Transcriptional regulator
I1A49_RS46230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS46240	COG0154	amidase activity
I1A49_RS46245	COG1309	transcriptional regulator
I1A49_RS46250	COG1309	transcriptional regulator
I1A49_RS46310	COG3384	dioxygenase
I1A49_RS46340	COG0596	Alpha beta hydrolase
I1A49_RS46365	COG2301	Belongs to the HpcH HpaI aldolase family
I1A49_RS46415	COG0318	PFAM AMP-dependent synthetase and ligase
I1A49_RS46430	COG3246	L-lysine catabolic process to acetate
I1A49_RS46440	COG2175	clavaminate synthase activity
I1A49_RS46455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A49_RS46480	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I1A49_RS46485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A49_RS46510	COG0006	proline dipeptidase activity
I1A49_RS46515	COG1802	Transcriptional regulator
I1A49_RS46550	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS46555	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS46560	COG0667	Aldo Keto reductase
I1A49_RS46565	COG1028	Short-chain dehydrogenase reductase Sdr
I1A49_RS46610	COG0596	Alpha beta hydrolase
I1A49_RS46645	COG0395	ABC-type sugar transport system, permease component
I1A49_RS46650	COG1175	transmembrane transport
I1A49_RS46665	COG0673	inositol 2-dehydrogenase activity
I1A49_RS46705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1A49_RS46710	COG0640	Transcriptional regulator
I1A49_RS46730	COG1012	belongs to the aldehyde dehydrogenase family
I1A49_RS46735	COG4608	Belongs to the ABC transporter superfamily
I1A49_RS46740	COG0444	Belongs to the ABC transporter superfamily
I1A49_RS46745	COG2186	Transcriptional regulator
I1A49_RS46750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A49_RS46755	COG0601	transmembrane transport
I1A49_RS46760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1A49_RS46815	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I1A49_RS46890	COG1621	beta-fructofuranosidase activity
I1A49_RS46895	COG1621	beta-fructofuranosidase activity
I1A49_RS46900	COG1609	Transcriptional regulator
I1A49_RS46905	COG0395	ABC-type sugar transport system, permease component
I1A49_RS46910	COG1175	transmembrane transport
I1A49_RS46915	COG1175	transmembrane transport
I1A49_RS46975	COG0142	geranyltranstransferase activity
I1A49_RS46990	COG0574	Belongs to the PEP-utilizing enzyme family
I1A49_RS46990	COG3848	Pyruvate phosphate dikinase
I1A49_RS47000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A49_RS47005	COG0473	3-isopropylmalate dehydrogenase activity
I1A49_RS47005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I1A49_RS47040	COG0604	alcohol dehydrogenase
I1A49_RS47040	COG3321	synthase
I1A49_RS47050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1A49_RS47055	COG0318	PFAM AMP-dependent synthetase and ligase