locus-tag	class	description
B4U39_RS00040	COG0009	L-threonylcarbamoyladenylate synthase
B4U39_RS00050	COG1278	Cold shock
B4U39_RS00140	COG0698	ribose 5-phosphate isomerase
B4U39_RS00180	COG0740	serine-type endopeptidase activity
B4U39_RS00185	COG0740	serine-type endopeptidase activity
B4U39_RS00265	COG0640	Transcriptional regulator
B4U39_RS00405	COG2124	cytochrome p450
B4U39_RS00445	COG0646	methionine synthase
B4U39_RS00445	COG1410	methionine synthase
B4U39_RS00450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U39_RS00455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4U39_RS00465	COG2132	Multicopper oxidase
B4U39_RS00495	COG0135	phosphoribosylanthranilate isomerase activity
B4U39_RS00500	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS00505	COG0662	Cupin 2, conserved barrel domain protein
B4U39_RS00510	COG0159	tryptophan synthase activity
B4U39_RS00515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4U39_RS00525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS00530	COG2030	dehydratase
B4U39_RS00535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS00550	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS00555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS00570	COG2072	flavoprotein involved in K transport
B4U39_RS00615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS00630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U39_RS00635	COG1104	cysteine desulfurase activity
B4U39_RS00725	COG3467	pyridoxamine 5'-phosphate
B4U39_RS00730	COG0596	Alpha beta hydrolase
B4U39_RS00780	COG2261	transglycosylase associated protein
B4U39_RS00835	COG2124	cytochrome p450
B4U39_RS00880	COG0464	growth
B4U39_RS00905	COG1136	(ABC) transporter
B4U39_RS00915	COG1653	transport
B4U39_RS00920	COG0366	Alpha amylase catalytic
B4U39_RS00930	COG1175	transmembrane transport
B4U39_RS00935	COG0395	ABC-type sugar transport system, permease component
B4U39_RS00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS00945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS00950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS00955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS00965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U39_RS00970	COG1126	abc transporter atp-binding protein
B4U39_RS00980	COG0745	RESPONSE REGULATOR receiver
B4U39_RS01000	COG1126	abc transporter atp-binding protein
B4U39_RS01005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U39_RS01010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS01025	COG1595	DNA-templated transcription, initiation
B4U39_RS01030	COG4677	pectinesterase activity
B4U39_RS01035	COG3866	Pectate lyase
B4U39_RS01045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B4U39_RS01055	COG0598	Magnesium transport protein CorA
B4U39_RS01060	COG0187	DNA topoisomerase II activity
B4U39_RS01065	COG3387	PFAM Glycoside hydrolase 15-related
B4U39_RS01080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4U39_RS01085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4U39_RS01090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4U39_RS01095	COG2376	Dihydroxyacetone kinase
B4U39_RS01115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B4U39_RS01145	COG0640	Transcriptional regulator
B4U39_RS01175	COG1335	isochorismatase
B4U39_RS01205	COG4221	oxidoreductase activity
B4U39_RS01215	COG2318	DinB family
B4U39_RS01225	COG0402	S-adenosylhomocysteine deaminase activity
B4U39_RS01275	COG1132	(ABC) transporter
B4U39_RS01305	COG4977	sequence-specific DNA binding
B4U39_RS01325	COG0477	Major facilitator Superfamily
B4U39_RS01375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U39_RS01435	COG2124	cytochrome p450
B4U39_RS01455	COG0181	hydroxymethylbilane synthase activity
B4U39_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS01490	COG0300	oxidoreductase activity
B4U39_RS01560	COG1191	sigma factor activity
B4U39_RS01610	COG1295	ribonuclease BN
B4U39_RS01620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B4U39_RS01745	COG1191	sigma factor activity
B4U39_RS01805	COG1191	sigma factor activity
B4U39_RS01810	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U39_RS01835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B4U39_RS01845	COG4213	ABC transporter substrate-binding protein
B4U39_RS01875	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U39_RS01885	COG2211	Major facilitator Superfamily
B4U39_RS01895	COG2318	DinB family
B4U39_RS01900	COG0596	Alpha beta hydrolase
B4U39_RS01910	COG0596	Alpha beta hydrolase
B4U39_RS01915	COG3226	Transcriptional regulator
B4U39_RS01945	COG0789	Transcriptional regulator
B4U39_RS01990	COG0477	Major facilitator Superfamily
B4U39_RS02110	COG1295	ribonuclease BN
B4U39_RS02165	COG0515	serine threonine protein kinase
B4U39_RS02185	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B4U39_RS02230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4U39_RS02245	COG2205	protein histidine kinase activity
B4U39_RS02250	COG0745	RESPONSE REGULATOR receiver
B4U39_RS02260	COG0785	Cytochrome C biogenesis protein
B4U39_RS02265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U39_RS02280	COG2340	Cysteine-rich secretory protein family
B4U39_RS02290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U39_RS02315	COG2015	COG2015, Alkyl sulfatase and related hydrolases
B4U39_RS02320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U39_RS02350	COG0745	RESPONSE REGULATOR receiver
B4U39_RS02355	COG0642	Histidine kinase
B4U39_RS02365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4U39_RS02375	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B4U39_RS02385	COG0475	glutathione-regulated potassium exporter activity
B4U39_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS02505	COG1476	TRANSCRIPTIONal
B4U39_RS02530	COG2135	peptidase activity
B4U39_RS02545	COG3655	Transcriptional regulator
B4U39_RS02595	COG3209	COG3209 Rhs family protein
B4U39_RS02605	COG0475	glutathione-regulated potassium exporter activity
B4U39_RS02615	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B4U39_RS02635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B4U39_RS02640	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B4U39_RS02645	COG2080	2 iron, 2 sulfur cluster binding
B4U39_RS02680	COG2770	Histidine kinase
B4U39_RS02680	COG2208	phosphoserine phosphatase activity
B4U39_RS02690	COG2172	sigma factor antagonist activity
B4U39_RS02695	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U39_RS02700	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U39_RS02715	COG2208	phosphoserine phosphatase activity
B4U39_RS02715	COG2770	Histidine kinase
B4U39_RS02720	COG0596	Alpha beta hydrolase
B4U39_RS02770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B4U39_RS02780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U39_RS02780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U39_RS02790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U39_RS02855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B4U39_RS02875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4U39_RS02895	COG4221	oxidoreductase activity
B4U39_RS02925	COG0483	inositol monophosphate 1-phosphatase activity
B4U39_RS02930	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B4U39_RS02960	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4U39_RS02965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4U39_RS02975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS02980	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS02985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS02990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS03020	COG2272	Belongs to the type-B carboxylesterase lipase family
B4U39_RS03050	COG2011	ABC-type metal ion transport system permease component
B4U39_RS03055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U39_RS03070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U39_RS03080	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B4U39_RS03085	COG0477	Major facilitator Superfamily
B4U39_RS03130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U39_RS03135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4U39_RS03170	COG1957	nucleoside hydrolase
B4U39_RS03175	COG2409	Drug exporters of the RND superfamily
B4U39_RS03210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B4U39_RS03235	COG5285	phytanoyl-CoA dioxygenase
B4U39_RS03240	COG1917	Cupin 2, conserved barrel domain protein
B4U39_RS03245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B4U39_RS03250	COG0456	acetyltransferase
B4U39_RS03285	COG1309	transcriptional regulator
B4U39_RS03290	COG0300	oxidoreductase activity
B4U39_RS03305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4U39_RS03370	COG0702	epimerase
B4U39_RS03395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS03425	COG2124	cytochrome p450
B4U39_RS03430	COG3903	Transcriptional regulator
B4U39_RS03430	COG3629	intracellular signal transduction
B4U39_RS03470	COG0477	Major facilitator Superfamily
B4U39_RS03480	COG3973	AAA domain
B4U39_RS03525	COG0745	RESPONSE REGULATOR receiver
B4U39_RS03530	COG5002	protein histidine kinase activity
B4U39_RS03535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4U39_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS03565	COG0546	phosphoglycolate phosphatase activity
B4U39_RS03575	COG1376	ErfK ybiS ycfS ynhG family protein
B4U39_RS03610	COG1505	serine-type exopeptidase activity
B4U39_RS03645	COG4989	oxidoreductase activity
B4U39_RS03660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U39_RS03670	COG4585	Histidine kinase
B4U39_RS03675	COG2197	response regulator
B4U39_RS03695	COG0667	Aldo Keto reductase
B4U39_RS03730	COG0431	NADPH-dependent FMN reductase
B4U39_RS03745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U39_RS03750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS03800	COG0435	Glutathione S-transferase
B4U39_RS03865	COG1404	Belongs to the peptidase S8 family
B4U39_RS03925	COG3473	Maleate cis-trans isomerase
B4U39_RS03930	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U39_RS03960	COG0657	acetylesterase activity
B4U39_RS03975	COG1609	Transcriptional regulator
B4U39_RS04000	COG2272	Belongs to the type-B carboxylesterase lipase family
B4U39_RS04030	COG3842	ATPase activity
B4U39_RS04050	COG2188	Transcriptional regulator
B4U39_RS04060	COG4941	Belongs to the sigma-70 factor family
B4U39_RS04110	COG1278	Cold shock
B4U39_RS04120	COG1846	Transcriptional regulator
B4U39_RS04125	COG0513	Belongs to the DEAD box helicase family
B4U39_RS04220	COG2910	NAD(P)H-binding
B4U39_RS04240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U39_RS04240	COG0072	phenylalanine-tRNA ligase activity
B4U39_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS04325	COG2814	Major facilitator Superfamily
B4U39_RS04365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4U39_RS04375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U39_RS04375	COG0463	Glycosyl transferase, family 2
B4U39_RS04375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U39_RS04375	COG0463	Glycosyl transferase, family 2
B4U39_RS04420	COG0531	amino acid
B4U39_RS04435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B4U39_RS04435	COG2010	Cytochrome c
B4U39_RS04460	COG1053	succinate dehydrogenase
B4U39_RS04475	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B4U39_RS04475	COG1672	PFAM Archaeal ATPase
B4U39_RS04510	COG1024	Enoyl-CoA hydratase
B4U39_RS04535	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS04540	COG2366	antibiotic biosynthetic process
B4U39_RS04545	COG0387	Pfam Sodium calcium exchanger
B4U39_RS04555	COG2070	2-Nitropropane dioxygenase
B4U39_RS04595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS04605	COG0515	serine threonine protein kinase
B4U39_RS04605	COG2815	serine threonine protein kinase
B4U39_RS04625	COG0346	lactoylglutathione lyase activity
B4U39_RS04655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4U39_RS04655	COG0617	tRNA 3'-terminal CCA addition
B4U39_RS04655	COG0517	IMP dehydrogenase activity
B4U39_RS04680	COG0517	IMP dehydrogenase activity
B4U39_RS04680	COG0516	GMP reductase activity
B4U39_RS04705	COG0640	Transcriptional regulator
B4U39_RS04710	COG1247	-acetyltransferase
B4U39_RS04755	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B4U39_RS04760	COG0589	response to stress
B4U39_RS04770	COG1063	alcohol dehydrogenase
B4U39_RS04775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B4U39_RS04800	COG1742	UPF0060 membrane protein
B4U39_RS04890	COG2326	polyphosphate kinase activity
B4U39_RS04920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U39_RS04945	COG0330	HflC and HflK could
B4U39_RS04960	COG0589	response to stress
B4U39_RS04970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U39_RS04975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U39_RS04980	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U39_RS04980	COG0022	dehydrogenase e1 component
B4U39_RS04990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U39_RS05000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4U39_RS05000	COG0617	tRNA 3'-terminal CCA addition
B4U39_RS05000	COG0517	IMP dehydrogenase activity
B4U39_RS05005	COG0517	IMP dehydrogenase activity
B4U39_RS05005	COG0516	GMP reductase activity
B4U39_RS05010	COG2239	Acts as a magnesium transporter
B4U39_RS05015	COG2239	Acts as a magnesium transporter
B4U39_RS05075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS05100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U39_RS05120	COG0516	GMP reductase activity
B4U39_RS05120	COG0517	IMP dehydrogenase activity
B4U39_RS05140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U39_RS05160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U39_RS05180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4U39_RS05180	COG0574	Belongs to the PEP-utilizing enzyme family
B4U39_RS05200	COG1063	alcohol dehydrogenase
B4U39_RS05205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B4U39_RS05215	COG0516	GMP reductase activity
B4U39_RS05215	COG0517	IMP dehydrogenase activity
B4U39_RS05225	COG1131	(ABC) transporter
B4U39_RS05230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U39_RS05230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U39_RS05235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U39_RS05240	COG0730	response to heat
B4U39_RS05245	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B4U39_RS05250	COG1937	Protein conserved in bacteria
B4U39_RS05260	COG0659	secondary active sulfate transmembrane transporter activity
B4U39_RS05265	COG0789	Transcriptional regulator
B4U39_RS05270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B4U39_RS05295	COG2217	Heavy metal translocating P-type atpase
B4U39_RS05335	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS05340	COG2318	DinB family
B4U39_RS05365	COG1349	DNA-binding transcription factor activity
B4U39_RS05380	COG0156	8-amino-7-oxononanoate synthase activity
B4U39_RS05385	COG1063	alcohol dehydrogenase
B4U39_RS05395	COG2226	methyltransferase
B4U39_RS05405	COG3387	PFAM Glycoside hydrolase 15-related
B4U39_RS05420	COG1982	Orn Lys Arg decarboxylase major
B4U39_RS05425	COG2259	Doxx family
B4U39_RS05465	COG0640	Transcriptional regulator
B4U39_RS05480	COG2814	Major facilitator Superfamily
B4U39_RS05490	COG0714	Associated with various cellular activities
B4U39_RS05515	COG1461	Dihydroxyacetone kinase
B4U39_RS05530	COG3585	molybdate ion transport
B4U39_RS05535	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4U39_RS05550	COG2197	response regulator
B4U39_RS05555	COG4585	Histidine kinase
B4U39_RS05585	COG0842	Transport permease protein
B4U39_RS05585	COG1716	ATPase activity
B4U39_RS05585	COG1131	(ABC) transporter
B4U39_RS05620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4U39_RS05635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS05640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U39_RS05675	COG2801	Transposase and inactivated derivatives
B4U39_RS05675	COG3415	Transposase
B4U39_RS05685	COG1397	ADP-ribosylglycohydrolase
B4U39_RS05690	COG0488	(ABC) transporter
B4U39_RS05695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4U39_RS05720	COG0464	growth
B4U39_RS05750	COG1940	carbohydrate kinase activity
B4U39_RS05810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U39_RS05815	COG0494	nUDIX hydrolase
B4U39_RS05835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4U39_RS05920	COG0671	phosphoesterase, PA-phosphatase related
B4U39_RS05945	COG0640	Transcriptional regulator
B4U39_RS05950	COG1902	pentaerythritol trinitrate reductase activity
B4U39_RS05965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4U39_RS05975	COG2706	6-phosphogluconolactonase activity
B4U39_RS05980	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B4U39_RS06020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B4U39_RS06020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS06025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4U39_RS06035	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B4U39_RS06090	COG2124	cytochrome p450
B4U39_RS06130	COG0475	glutathione-regulated potassium exporter activity
B4U39_RS06145	COG0406	alpha-ribazole phosphatase activity
B4U39_RS06160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U39_RS06175	COG2124	cytochrome p450
B4U39_RS06180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U39_RS06185	COG1116	anion transmembrane transporter activity
B4U39_RS06200	COG2072	flavoprotein involved in K transport
B4U39_RS06230	COG1132	(ABC) transporter
B4U39_RS06245	COG1132	(ABC) transporter
B4U39_RS06250	COG1132	(ABC) transporter
B4U39_RS06265	COG1946	Acyl-CoA thioesterase
B4U39_RS06270	COG3012	SEC-C Motif Domain Protein
B4U39_RS06280	COG2018	Roadblock/LC7 domain
B4U39_RS06360	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS06390	COG1733	regulation of RNA biosynthetic process
B4U39_RS06410	COG2318	DinB family
B4U39_RS06420	COG2814	Major facilitator Superfamily
B4U39_RS06435	COG1864	DNA RNA non-specific endonuclease
B4U39_RS06435	COG3591	Belongs to the peptidase S1B family
B4U39_RS06445	COG1131	(ABC) transporter
B4U39_RS06465	COG0596	Alpha beta hydrolase
B4U39_RS06480	COG4176	ABC-type proline glycine betaine transport system permease component
B4U39_RS06485	COG4175	Glycine betaine
B4U39_RS06485	COG0517	IMP dehydrogenase activity
B4U39_RS06495	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS06540	COG1228	amidohydrolase
B4U39_RS06545	COG2382	esterase
B4U39_RS06550	COG1132	(ABC) transporter
B4U39_RS06560	COG1132	(ABC) transporter
B4U39_RS06565	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4U39_RS06570	COG1120	ATPase activity
B4U39_RS06575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U39_RS06580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U39_RS06590	COG2409	Drug exporters of the RND superfamily
B4U39_RS06595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS06595	COG3321	synthase
B4U39_RS06640	COG1132	(ABC) transporter
B4U39_RS06670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4U39_RS06705	COG0702	epimerase
B4U39_RS06715	COG1595	DNA-templated transcription, initiation
B4U39_RS06740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4U39_RS06745	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B4U39_RS06765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS06790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U39_RS06795	COG1309	transcriptional regulator
B4U39_RS06805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U39_RS06825	COG2824	Alkylphosphonate utilization operon protein PhnA
B4U39_RS06835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U39_RS06880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U39_RS06905	COG4249	Peptidase C14 caspase catalytic subunit p20
B4U39_RS06905	COG2319	Wd-40 repeat
B4U39_RS06910	COG1396	sequence-specific DNA binding
B4U39_RS06910	COG1917	Cupin 2, conserved barrel domain protein
B4U39_RS06940	COG2124	cytochrome p450
B4U39_RS06945	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS06950	COG0156	8-amino-7-oxononanoate synthase activity
B4U39_RS06955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS06960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U39_RS06965	COG2814	Major facilitator Superfamily
B4U39_RS06970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U39_RS06975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U39_RS06975	COG0512	Glutamine amidotransferase of anthranilate synthase
B4U39_RS07000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U39_RS07005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U39_RS07015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4U39_RS07020	COG0473	3-isopropylmalate dehydrogenase activity
B4U39_RS07045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS07075	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS07085	COG0300	oxidoreductase activity
B4U39_RS07090	COG2814	Major facilitator Superfamily
B4U39_RS07120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U39_RS07125	COG0601	transmembrane transport
B4U39_RS07160	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS07170	COG0242	peptide deformylase activity
B4U39_RS07180	COG3442	glutamine amidotransferase
B4U39_RS07185	COG0205	6-phosphofructokinase activity
B4U39_RS07205	COG0829	nickel cation binding
B4U39_RS07210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B4U39_RS07220	COG0804	urea catabolic process
B4U39_RS07225	COG0832	Belongs to the urease beta subunit family
B4U39_RS07230	COG0831	urea catabolic process
B4U39_RS07255	COG0156	8-amino-7-oxononanoate synthase activity
B4U39_RS07260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4U39_RS07265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U39_RS07270	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4U39_RS07275	COG0456	acetyltransferase
B4U39_RS07295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4U39_RS07320	COG4585	Histidine kinase
B4U39_RS07325	COG2197	response regulator
B4U39_RS07330	COG1940	carbohydrate kinase activity
B4U39_RS07335	COG2188	Transcriptional regulator
B4U39_RS07340	COG2267	carboxylic ester hydrolase activity
B4U39_RS07365	COG1522	sequence-specific DNA binding
B4U39_RS07370	COG0419	ATPase involved in DNA repair
B4U39_RS07375	COG0420	3'-5' exonuclease activity
B4U39_RS07380	COG1739	Uncharacterized protein family UPF0029
B4U39_RS07390	COG1832	CoA-binding protein
B4U39_RS07405	COG0110	maltose O-acetyltransferase activity
B4U39_RS07460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4U39_RS07475	COG1968	undecaprenyl-diphosphatase activity
B4U39_RS07485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B4U39_RS07495	COG2318	DinB family
B4U39_RS07510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4U39_RS07570	COG0697	spore germination
B4U39_RS07585	COG1695	Transcriptional regulator
B4U39_RS07620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U39_RS07620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U39_RS07630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U39_RS07650	COG1716	ATPase activity
B4U39_RS07670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4U39_RS07705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4U39_RS07715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U39_RS07730	COG0640	Transcriptional regulator
B4U39_RS07755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS07770	COG2018	Roadblock/LC7 domain
B4U39_RS07805	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B4U39_RS07810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4U39_RS07815	COG1984	allophanate hydrolase subunit 2
B4U39_RS07840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U39_RS07850	COG2270	Major facilitator Superfamily
B4U39_RS07865	COG0463	Glycosyl transferase, family 2
B4U39_RS07905	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS07910	COG1309	transcriptional regulator
B4U39_RS07925	COG0572	uridine kinase
B4U39_RS07955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B4U39_RS07960	COG0140	phosphoribosyl-ATP diphosphatase activity
B4U39_RS07965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4U39_RS07970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U39_RS07970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U39_RS07975	COG3201	nicotinamide mononucleotide transporter
B4U39_RS07995	COG1595	DNA-templated transcription, initiation
B4U39_RS08005	COG1940	carbohydrate kinase activity
B4U39_RS08005	COG1846	Transcriptional regulator
B4U39_RS08010	COG0738	Major facilitator superfamily
B4U39_RS08015	COG2233	PERMEase
B4U39_RS08050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U39_RS08070	COG0531	amino acid
B4U39_RS08080	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS08085	COG2755	lipolytic protein G-D-S-L family
B4U39_RS08105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U39_RS08110	COG3275	phosphorelay sensor kinase activity
B4U39_RS08130	COG3548	integral membrane protein
B4U39_RS08170	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS08180	COG0489	protein tyrosine kinase activity
B4U39_RS08185	COG2208	phosphoserine phosphatase activity
B4U39_RS08185	COG2770	Histidine kinase
B4U39_RS08205	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U39_RS08225	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B4U39_RS08245	COG0028	Belongs to the TPP enzyme family
B4U39_RS08260	COG0492	ferredoxin-NADP+ reductase activity
B4U39_RS08290	COG2390	Transcriptional regulator
B4U39_RS08295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4U39_RS08325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4U39_RS08340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4U39_RS08355	COG0194	GDP metabolic process
B4U39_RS08365	COG0284	orotidine-5'-phosphate decarboxylase activity
B4U39_RS08370	COG0167	dihydroorotate dehydrogenase activity
B4U39_RS08375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4U39_RS08380	COG0505	Belongs to the CarA family
B4U39_RS08390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U39_RS08395	COG0540	Belongs to the ATCase OTCase family
B4U39_RS08400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B4U39_RS08410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4U39_RS08415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4U39_RS08420	COG0006	proline dipeptidase activity
B4U39_RS08430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4U39_RS08435	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4U39_RS08440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4U39_RS08445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4U39_RS08455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4U39_RS08465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4U39_RS08470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4U39_RS08490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4U39_RS08515	COG0124	histidyl-tRNA synthetase
B4U39_RS08525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4U39_RS08530	COG1196	nuclear chromosome segregation
B4U39_RS08535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U39_RS08540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U39_RS08545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U39_RS08550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U39_RS08560	COG2255	four-way junction helicase activity
B4U39_RS08565	COG0632	four-way junction helicase activity
B4U39_RS08570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B4U39_RS08575	COG0217	transcriptional regulatory protein
B4U39_RS08580	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B4U39_RS08585	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B4U39_RS08595	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS08600	COG1560	Kdo2-lipid A biosynthetic process
B4U39_RS08605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4U39_RS08630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U39_RS08655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4U39_RS08700	COG0456	acetyltransferase
B4U39_RS08700	COG0454	-acetyltransferase
B4U39_RS08710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U39_RS08755	COG1648	precorrin-2 dehydrogenase activity
B4U39_RS08755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4U39_RS08760	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B4U39_RS08775	COG1464	Belongs to the NlpA lipoprotein family
B4U39_RS08780	COG2011	ABC-type metal ion transport system permease component
B4U39_RS08785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U39_RS08810	COG0584	glycerophosphoryl diester phosphodiesterase
B4U39_RS08815	COG0204	Acyl-transferase
B4U39_RS08815	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS08825	COG0477	Major facilitator Superfamily
B4U39_RS08840	COG0165	Argininosuccinate lyase
B4U39_RS08845	COG0137	argininosuccinate synthase activity
B4U39_RS08860	COG1438	arginine binding
B4U39_RS08865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U39_RS08870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B4U39_RS08875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B4U39_RS08880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B4U39_RS08895	COG0697	spore germination
B4U39_RS08905	COG1649	PFAM Uncharacterised BCR, COG1649
B4U39_RS08925	COG0072	phenylalanine-tRNA ligase activity
B4U39_RS08925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U39_RS08930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B4U39_RS08935	COG5002	protein histidine kinase activity
B4U39_RS08940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U39_RS08945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B4U39_RS08950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4U39_RS08955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4U39_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS09010	COG0174	glutamine synthetase
B4U39_RS09020	COG1113	amino acid transport
B4U39_RS09025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B4U39_RS09065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U39_RS09085	COG1309	transcriptional regulator
B4U39_RS09100	COG0805	protein transport
B4U39_RS09105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U39_RS09140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B4U39_RS09150	COG1609	Transcriptional regulator
B4U39_RS09155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B4U39_RS09160	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B4U39_RS09175	COG4122	O-methyltransferase activity
B4U39_RS09180	COG1222	aaa ATPase
B4U39_RS09200	COG1994	Peptidase M50
B4U39_RS09200	COG0517	IMP dehydrogenase activity
B4U39_RS09210	COG2197	response regulator
B4U39_RS09230	COG0646	methionine synthase
B4U39_RS09230	COG1410	methionine synthase
B4U39_RS09235	COG1414	Transcriptional regulator
B4U39_RS09240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4U39_RS09245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4U39_RS09250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4U39_RS09260	COG0215	cysteine-tRNA ligase activity
B4U39_RS09280	COG0598	Magnesium transport protein CorA
B4U39_RS09290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS09295	COG0667	Aldo Keto reductase
B4U39_RS09325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U39_RS09335	COG1595	DNA-templated transcription, initiation
B4U39_RS09345	COG1113	amino acid transport
B4U39_RS09370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B4U39_RS09375	COG2149	membrane
B4U39_RS09400	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS09415	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS09420	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS09425	COG3876	Protein conserved in bacteria
B4U39_RS09445	COG0789	Transcriptional regulator
B4U39_RS09465	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS09490	COG2851	Citrate transporter
B4U39_RS09495	COG0243	molybdopterin cofactor binding
B4U39_RS09500	COG1309	transcriptional regulator
B4U39_RS09520	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B4U39_RS09525	COG2188	Transcriptional regulator
B4U39_RS09550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B4U39_RS09565	COG2755	lipolytic protein G-D-S-L family
B4U39_RS09590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B4U39_RS09610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U39_RS09615	COG0587	DNA-directed DNA polymerase activity
B4U39_RS09645	COG0641	radical SAM
B4U39_RS09690	COG1799	cell septum assembly
B4U39_RS09695	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS09705	COG0477	Major facilitator Superfamily
B4U39_RS09715	COG0671	phosphoesterase, PA-phosphatase related
B4U39_RS09745	COG1160	GTP binding
B4U39_RS09755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4U39_RS09785	COG3541	Predicted nucleotidyltransferase
B4U39_RS09810	COG1187	pseudouridine synthase activity
B4U39_RS09815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4U39_RS09820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4U39_RS09835	COG0686	Belongs to the AlaDH PNT family
B4U39_RS09845	COG0494	nUDIX hydrolase
B4U39_RS09850	COG0504	CTP synthase activity
B4U39_RS09855	COG3387	PFAM Glycoside hydrolase 15-related
B4U39_RS09860	COG0277	FAD linked oxidase domain protein
B4U39_RS09875	COG0497	DNA recombination
B4U39_RS09880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4U39_RS09900	COG1120	ATPase activity
B4U39_RS09905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U39_RS09910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U39_RS09915	COG0647	UMP catabolic process
B4U39_RS09950	COG2094	Belongs to the DNA glycosylase MPG family
B4U39_RS09960	COG1881	PFAM PEBP family protein
B4U39_RS09985	COG1119	ATPase activity
B4U39_RS10000	COG2197	response regulator
B4U39_RS10005	COG4585	Histidine kinase
B4U39_RS10010	COG4221	oxidoreductase activity
B4U39_RS10015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B4U39_RS10025	COG1131	(ABC) transporter
B4U39_RS10025	COG0842	Transport permease protein
B4U39_RS10025	COG1716	ATPase activity
B4U39_RS10035	COG3830	Belongs to the UPF0237 family
B4U39_RS10035	COG0560	Phosphoserine phosphatase
B4U39_RS10055	COG2186	Transcriptional regulator
B4U39_RS10065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4U39_RS10070	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS10085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U39_RS10105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4U39_RS10110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U39_RS10125	COG1063	alcohol dehydrogenase
B4U39_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS10210	COG1302	Protein conserved in bacteria
B4U39_RS10215	COG1024	Enoyl-CoA hydratase
B4U39_RS10225	COG0488	(ABC) transporter
B4U39_RS10250	COG0306	phosphate transporter
B4U39_RS10260	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B4U39_RS10265	COG1492	cobalamin metabolic process
B4U39_RS10280	COG1797	cobyrinic acid a,c-diamide synthase activity
B4U39_RS10310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U39_RS10330	COG2197	response regulator
B4U39_RS10390	COG2171	N-acyltransferase activity
B4U39_RS10405	COG3226	Transcriptional regulator
B4U39_RS10410	COG2076	Multidrug Resistance protein
B4U39_RS10420	COG2151	metal-sulfur cluster biosynthetic enzyme
B4U39_RS10425	COG0822	iron-sulfur transferase activity
B4U39_RS10430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U39_RS10435	COG0396	ATPase activity
B4U39_RS10445	COG0719	Fe-S assembly protein
B4U39_RS10460	COG1131	(ABC) transporter
B4U39_RS10475	COG1612	heme a metabolic process
B4U39_RS10490	COG0109	protoheme IX farnesyltransferase activity
B4U39_RS10500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U39_RS10515	COG0363	glucosamine-6-phosphate deaminase activity
B4U39_RS10520	COG0166	Belongs to the GPI family
B4U39_RS10530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U39_RS10535	COG0149	triose-phosphate isomerase activity
B4U39_RS10540	COG0126	phosphoglycerate kinase activity
B4U39_RS10545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4U39_RS10555	COG1481	regulation of sporulation
B4U39_RS10565	COG1660	Displays ATPase and GTPase activities
B4U39_RS10570	COG0322	excinuclease ABC activity
B4U39_RS10600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4U39_RS10610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U39_RS10615	COG0477	Major facilitator Superfamily
B4U39_RS10635	COG0556	nucleotide-excision repair
B4U39_RS10640	COG0584	glycerophosphoryl diester phosphodiesterase
B4U39_RS10645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U39_RS10650	COG0477	Major facilitator Superfamily
B4U39_RS10660	COG2226	methyltransferase
B4U39_RS10665	COG2313	pseudouridylate synthase activity
B4U39_RS10695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U39_RS10710	COG4279	zinc finger
B4U39_RS10715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4U39_RS10740	COG0237	dephospho-CoA kinase activity
B4U39_RS10750	COG0539	negative regulation of cytoplasmic translation
B4U39_RS10755	COG2226	methyltransferase
B4U39_RS10755	COG1073	alpha beta
B4U39_RS10760	COG1643	Atp-dependent helicase
B4U39_RS10870	COG0737	Belongs to the 5'-nucleotidase family
B4U39_RS10890	COG0287	Prephenate dehydrogenase
B4U39_RS10890	COG1605	Chorismate mutase
B4U39_RS10910	COG2197	response regulator
B4U39_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS10945	COG1024	Enoyl-CoA hydratase
B4U39_RS10965	COG2365	Tyrosine phosphatase family
B4U39_RS10970	COG0513	Belongs to the DEAD box helicase family
B4U39_RS10975	COG1278	Cold shock
B4U39_RS10985	COG0183	Belongs to the thiolase family
B4U39_RS10990	COG1309	transcriptional regulator
B4U39_RS11000	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS11030	COG0657	acetylesterase activity
B4U39_RS11095	COG0069	glutamate synthase activity
B4U39_RS11095	COG0067	glutamate synthase
B4U39_RS11095	COG0070	glutamate synthase
B4U39_RS11125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U39_RS11130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B4U39_RS11135	COG2301	Belongs to the HpcH HpaI aldolase family
B4U39_RS11140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B4U39_RS11150	COG0159	tryptophan synthase activity
B4U39_RS11155	COG0133	tryptophan synthase activity
B4U39_RS11165	COG0134	indole-3-glycerol-phosphate synthase activity
B4U39_RS11190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4U39_RS11200	COG0107	imidazoleglycerol-phosphate synthase activity
B4U39_RS11205	COG0251	oxidation-reduction process
B4U39_RS11210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B4U39_RS11215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4U39_RS11220	COG0131	Imidazoleglycerol-phosphate dehydratase
B4U39_RS11225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U39_RS11230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B4U39_RS11245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4U39_RS11265	COG1432	Conserved Protein
B4U39_RS11270	COG0587	DNA-directed DNA polymerase activity
B4U39_RS11325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4U39_RS11340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B4U39_RS11355	COG1799	cell septum assembly
B4U39_RS11375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4U39_RS11380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U39_RS11390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U39_RS11395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U39_RS11405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4U39_RS11410	COG0768	penicillin binding
B4U39_RS11420	COG0275	rRNA processing
B4U39_RS11430	COG0714	Associated with various cellular activities
B4U39_RS11445	COG1309	transcriptional regulator
B4U39_RS11455	COG1131	(ABC) transporter
B4U39_RS11465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U39_RS11480	COG1233	COG1233 Phytoene dehydrogenase and related
B4U39_RS11495	COG0352	thiamine-phosphate diphosphorylase activity
B4U39_RS11510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U39_RS11510	COG2022	thiamine diphosphate biosynthetic process
B4U39_RS11520	COG2022	thiamine diphosphate biosynthetic process
B4U39_RS11525	COG0515	serine threonine protein kinase
B4U39_RS11525	COG2815	serine threonine protein kinase
B4U39_RS11530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B4U39_RS11540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4U39_RS11545	COG2193	ferroxidase activity
B4U39_RS11555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B4U39_RS11570	COG0205	6-phosphofructokinase activity
B4U39_RS11575	COG2197	response regulator
B4U39_RS11580	COG4585	Histidine kinase
B4U39_RS11605	COG1940	carbohydrate kinase activity
B4U39_RS11615	COG0003	Pfam Anion-transporting ATPase
B4U39_RS11640	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS11655	COG0791	NLP P60 protein
B4U39_RS11680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U39_RS11685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4U39_RS11690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4U39_RS11695	COG0723	plastoquinol--plastocyanin reductase activity
B4U39_RS11700	COG2010	Cytochrome c
B4U39_RS11705	COG1845	cytochrome c oxidase, subunit III
B4U39_RS11715	COG1376	ErfK ybiS ycfS ynhG family protein
B4U39_RS11725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4U39_RS11730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4U39_RS11740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U39_RS11760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B4U39_RS11765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4U39_RS11770	COG2197	response regulator
B4U39_RS11775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B4U39_RS11800	COG2226	methyltransferase
B4U39_RS11815	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B4U39_RS11820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4U39_RS11820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U39_RS11860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4U39_RS11865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U39_RS11870	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U39_RS11880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B4U39_RS11925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B4U39_RS11930	COG0321	lipoyl(octanoyl) transferase activity
B4U39_RS11980	COG1846	Transcriptional regulator
B4U39_RS11985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U39_RS11990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4U39_RS12000	COG0673	inositol 2-dehydrogenase activity
B4U39_RS12020	COG0745	RESPONSE REGULATOR receiver
B4U39_RS12045	COG2365	Tyrosine phosphatase family
B4U39_RS12100	COG0366	Alpha amylase catalytic
B4U39_RS12110	COG1175	transmembrane transport
B4U39_RS12120	COG0366	Alpha amylase catalytic
B4U39_RS12125	COG1609	Transcriptional regulator
B4U39_RS12145	COG3511	phospholipase C
B4U39_RS12170	COG2340	Cysteine-rich secretory protein family
B4U39_RS12175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B4U39_RS12190	COG0270	DNA (cytosine-5-)-methyltransferase activity
B4U39_RS12200	COG0174	glutamine synthetase
B4U39_RS12220	COG2188	Transcriptional regulator
B4U39_RS12280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B4U39_RS12285	COG0174	glutamine synthetase
B4U39_RS12310	COG2267	carboxylic ester hydrolase activity
B4U39_RS12325	COG2132	Multicopper oxidase
B4U39_RS12335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4U39_RS12335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U39_RS12345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B4U39_RS12365	COG1994	Peptidase M50
B4U39_RS12425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U39_RS12430	COG1120	ATPase activity
B4U39_RS12440	COG2837	iron assimilation
B4U39_RS12445	COG0672	)-iron permease
B4U39_RS12450	COG0384	phenazine biosynthesis protein PhzF
B4U39_RS12460	COG2814	Major facilitator Superfamily
B4U39_RS12470	COG1834	amidinotransferase
B4U39_RS12485	COG3022	response to hydroperoxide
B4U39_RS12525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4U39_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS12545	COG2030	dehydratase
B4U39_RS12555	COG1595	DNA-templated transcription, initiation
B4U39_RS12570	COG0183	Belongs to the thiolase family
B4U39_RS12575	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS12580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U39_RS12590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U39_RS12590	COG0515	serine threonine protein kinase
B4U39_RS12620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS12655	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS12660	COG1309	transcriptional regulator
B4U39_RS12685	COG1657	PFAM Prenyltransferase squalene oxidase
B4U39_RS12700	COG3845	ABC transporter
B4U39_RS12715	COG0183	Belongs to the thiolase family
B4U39_RS12720	COG2124	cytochrome p450
B4U39_RS12770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U39_RS12780	COG2318	DinB family
B4U39_RS12845	COG2154	pterin-4-alpha-carbinolamine dehydratase
B4U39_RS12890	COG1358	cellular component organization or biogenesis
B4U39_RS12935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B4U39_RS12940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U39_RS12950	COG1309	transcriptional regulator
B4U39_RS12965	COG0667	Aldo Keto reductase
B4U39_RS12970	COG0789	Transcriptional regulator
B4U39_RS12995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS13000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U39_RS13005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS13025	COG1309	transcriptional regulator
B4U39_RS13040	COG1733	regulation of RNA biosynthetic process
B4U39_RS13055	COG1764	response to oxidative stress
B4U39_RS13060	COG2130	NADP-dependent
B4U39_RS13080	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4U39_RS13085	COG1077	Cell shape determining protein MreB Mrl
B4U39_RS13095	COG1522	sequence-specific DNA binding
B4U39_RS13110	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4U39_RS13110	COG0825	malonyl-CoA metabolic process
B4U39_RS13115	COG0477	Major facilitator Superfamily
B4U39_RS13120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B4U39_RS13150	COG1070	Carbohydrate kinase
B4U39_RS13175	COG0243	molybdopterin cofactor binding
B4U39_RS13190	COG2949	membrane
B4U39_RS13200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B4U39_RS13210	COG0358	DNA primase activity
B4U39_RS13225	COG2205	protein histidine kinase activity
B4U39_RS13250	COG1017	nitric oxide dioxygenase activity
B4U39_RS13250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4U39_RS13255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U39_RS13260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U39_RS13260	COG2146	nitrite reductase [NAD(P)H] activity
B4U39_RS13265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U39_RS13265	COG2146	nitrite reductase [NAD(P)H] activity
B4U39_RS13285	COG0574	Belongs to the PEP-utilizing enzyme family
B4U39_RS13285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4U39_RS13295	COG0477	Major facilitator Superfamily
B4U39_RS13310	COG0667	Aldo Keto reductase
B4U39_RS13315	COG1309	transcriptional regulator
B4U39_RS13325	COG0423	glycine-tRNA ligase activity
B4U39_RS13330	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4U39_RS13330	COG3443	Belongs to the bacterial solute-binding protein 9 family
B4U39_RS13335	COG1121	(ABC) transporter
B4U39_RS13340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U39_RS13350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4U39_RS13355	COG1381	Involved in DNA repair and RecF pathway recombination
B4U39_RS13360	COG2233	PERMEase
B4U39_RS13370	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS13375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U39_RS13400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4U39_RS13415	COG2271	Major facilitator Superfamily
B4U39_RS13425	COG2315	Protein conserved in bacteria
B4U39_RS13435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B4U39_RS13445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U39_RS13450	COG1234	tRNA 3'-trailer cleavage
B4U39_RS13455	COG0537	adenosine 5'-monophosphoramidase activity
B4U39_RS13465	COG2070	2-Nitropropane dioxygenase
B4U39_RS13470	COG0484	heat shock protein binding
B4U39_RS13475	COG1420	regulation of RNA biosynthetic process
B4U39_RS13500	COG0481	GTPase activity
B4U39_RS13505	COG0268	Binds directly to 16S ribosomal RNA
B4U39_RS13525	COG2353	YceI-like domain
B4U39_RS13530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U39_RS13540	COG1307	EDD domain protein, DegV family
B4U39_RS13550	COG0495	leucyl-tRNA aminoacylation
B4U39_RS13570	COG0588	phosphoglycerate mutase activity
B4U39_RS13575	COG0799	negative regulation of ribosome biogenesis
B4U39_RS13585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4U39_RS13590	COG0501	Belongs to the peptidase M48B family
B4U39_RS13605	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B4U39_RS13615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4U39_RS13625	COG0463	Glycosyl transferase, family 2
B4U39_RS13630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U39_RS13630	COG0463	Glycosyl transferase, family 2
B4U39_RS13635	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS13645	COG1216	Glycosyl transferase, family 2
B4U39_RS13650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4U39_RS13655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B4U39_RS13660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B4U39_RS13665	COG1530	ribonuclease E activity
B4U39_RS13690	COG0772	Belongs to the SEDS family
B4U39_RS13695	COG0768	penicillin binding
B4U39_RS13710	COG1077	Cell shape determining protein MreB Mrl
B4U39_RS13715	COG0105	UTP biosynthetic process
B4U39_RS13725	COG0285	dihydrofolate synthase activity
B4U39_RS13730	COG1077	Cell shape determining protein MreB Mrl
B4U39_RS13735	COG4585	Histidine kinase
B4U39_RS13740	COG0525	valine-tRNA ligase activity
B4U39_RS13750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4U39_RS13755	COG0740	serine-type endopeptidase activity
B4U39_RS13760	COG0740	serine-type endopeptidase activity
B4U39_RS13765	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4U39_RS13815	COG4552	Acetyltransferase involved in intracellular survival and related
B4U39_RS13830	COG1113	amino acid transport
B4U39_RS13840	COG1113	amino acid transport
B4U39_RS13850	COG1113	amino acid transport
B4U39_RS13855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4U39_RS13860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4U39_RS13890	COG2234	aminopeptidase activity
B4U39_RS13905	COG0583	DNA-binding transcription factor activity
B4U39_RS13915	COG0697	spore germination
B4U39_RS13920	COG1846	Transcriptional regulator
B4U39_RS13935	COG3291	Pkd domain containing protein
B4U39_RS13935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B4U39_RS13945	COG0668	transmembrane transport
B4U39_RS13960	COG1175	transmembrane transport
B4U39_RS13965	COG0395	ABC-type sugar transport system, permease component
B4U39_RS13970	COG1486	melibiose metabolic process
B4U39_RS13985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U39_RS13995	COG0515	serine threonine protein kinase
B4U39_RS14015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B4U39_RS14020	COG2346	COG2346, Truncated hemoglobins
B4U39_RS14050	COG0629	single-stranded DNA binding
B4U39_RS14080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4U39_RS14105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U39_RS14105	COG0515	serine threonine protein kinase
B4U39_RS14135	COG3962	Belongs to the TPP enzyme family
B4U39_RS14140	COG3718	enzyme involved in inositol metabolism
B4U39_RS14150	COG1082	Xylose isomerase domain protein TIM barrel
B4U39_RS14155	COG0673	inositol 2-dehydrogenase activity
B4U39_RS14180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4U39_RS14190	COG1846	Transcriptional regulator
B4U39_RS14190	COG0456	acetyltransferase
B4U39_RS14205	COG1472	Belongs to the glycosyl hydrolase 3 family
B4U39_RS14235	COG0028	Belongs to the TPP enzyme family
B4U39_RS14255	COG1946	Acyl-CoA thioesterase
B4U39_RS14265	COG1309	transcriptional regulator
B4U39_RS14270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U39_RS14285	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS14295	COG2375	cellular response to nickel ion
B4U39_RS14300	COG0076	glutamate decarboxylase activity
B4U39_RS14305	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B4U39_RS14330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4U39_RS14340	COG0589	response to stress
B4U39_RS14350	COG4977	sequence-specific DNA binding
B4U39_RS14380	COG0395	ABC-type sugar transport system, permease component
B4U39_RS14390	COG0702	epimerase
B4U39_RS14395	COG1309	transcriptional regulator
B4U39_RS14415	COG0745	RESPONSE REGULATOR receiver
B4U39_RS14425	COG0500	methyltransferase
B4U39_RS14445	COG0406	alpha-ribazole phosphatase activity
B4U39_RS14470	COG1309	transcriptional regulator
B4U39_RS14475	COG4221	oxidoreductase activity
B4U39_RS14560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS14600	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS14605	COG3397	chitin binding
B4U39_RS14670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U39_RS14675	COG2188	Transcriptional regulator
B4U39_RS14690	COG0673	inositol 2-dehydrogenase activity
B4U39_RS14695	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U39_RS14700	COG0706	membrane insertase activity
B4U39_RS14710	COG3764	Sortase (surface protein transpeptidase)
B4U39_RS14745	COG2733	membrane
B4U39_RS14770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U39_RS14805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4U39_RS14815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B4U39_RS14820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U39_RS14825	COG1263	PTS System
B4U39_RS14830	COG1263	PTS System
B4U39_RS14835	COG1234	tRNA 3'-trailer cleavage
B4U39_RS14845	COG3189	MarR family transcriptional regulator
B4U39_RS14865	COG1113	amino acid transport
B4U39_RS14875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B4U39_RS14885	COG1335	isochorismatase
B4U39_RS14920	COG0277	FAD linked oxidase domain protein
B4U39_RS14930	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B4U39_RS14965	COG3654	unkown
B4U39_RS15005	COG1404	Belongs to the peptidase S8 family
B4U39_RS15035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B4U39_RS15045	COG1678	Uncharacterized ACR, COG1678
B4U39_RS15050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U39_RS15055	COG0776	regulation of translation
B4U39_RS15065	COG3973	AAA domain
B4U39_RS15090	COG0583	DNA-binding transcription factor activity
B4U39_RS15115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B4U39_RS15120	COG0793	Belongs to the peptidase S41A family
B4U39_RS15125	COG2177	Part of the ABC transporter FtsEX involved in
B4U39_RS15130	COG2884	Cell division ATP-binding protein ftsE
B4U39_RS15140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B4U39_RS15150	COG0515	serine threonine protein kinase
B4U39_RS15155	COG0515	serine threonine protein kinase
B4U39_RS15165	COG1653	transport
B4U39_RS15170	COG1175	transmembrane transport
B4U39_RS15175	COG0395	ABC-type sugar transport system, permease component
B4U39_RS15180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U39_RS15180	COG0463	Glycosyl transferase, family 2
B4U39_RS15195	COG1388	LysM domain
B4U39_RS15195	COG1134	teichoic acid transport
B4U39_RS15205	COG0546	phosphoglycolate phosphatase activity
B4U39_RS15220	COG0653	protein targeting
B4U39_RS15235	COG2197	response regulator
B4U39_RS15240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4U39_RS15250	COG0823	Involved in the tonB-independent uptake of proteins
B4U39_RS15255	COG5002	protein histidine kinase activity
B4U39_RS15255	COG5000	phosphorelay sensor kinase activity
B4U39_RS15260	COG0745	RESPONSE REGULATOR receiver
B4U39_RS15280	COG0714	Associated with various cellular activities
B4U39_RS15330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B4U39_RS15335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U39_RS15335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U39_RS15335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U39_RS15340	COG0681	Belongs to the peptidase S26 family
B4U39_RS15350	COG1482	cell wall glycoprotein biosynthetic process
B4U39_RS15360	COG2835	tetraacyldisaccharide 4'-kinase activity
B4U39_RS15365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U39_RS15400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4U39_RS15405	COG0778	Nitroreductase
B4U39_RS15405	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B4U39_RS15425	COG1316	TRANSCRIPTIONal
B4U39_RS15430	COG1316	TRANSCRIPTIONal
B4U39_RS15450	COG1607	acyl-coa hydrolase
B4U39_RS15455	COG1316	TRANSCRIPTIONal
B4U39_RS15470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4U39_RS15500	COG2205	protein histidine kinase activity
B4U39_RS15505	COG0745	RESPONSE REGULATOR receiver
B4U39_RS15510	COG3104	oligopeptide transport
B4U39_RS15540	COG1228	amidohydrolase
B4U39_RS15555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B4U39_RS15580	COG2755	lipolytic protein G-D-S-L family
B4U39_RS15585	COG0183	Belongs to the thiolase family
B4U39_RS15615	COG0577	efflux transmembrane transporter activity
B4U39_RS15615	COG1136	(ABC) transporter
B4U39_RS15620	COG0577	efflux transmembrane transporter activity
B4U39_RS15625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4U39_RS15630	COG1252	NADH dehydrogenase
B4U39_RS15650	COG0148	phosphopyruvate hydratase activity
B4U39_RS15665	COG2124	cytochrome p450
B4U39_RS15690	COG2815	serine threonine protein kinase
B4U39_RS15690	COG0515	serine threonine protein kinase
B4U39_RS15710	COG0577	efflux transmembrane transporter activity
B4U39_RS15715	COG1136	(ABC) transporter
B4U39_RS15720	COG2814	Major facilitator Superfamily
B4U39_RS15740	COG0596	Alpha beta hydrolase
B4U39_RS15780	COG4585	Histidine kinase
B4U39_RS15790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B4U39_RS15795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4U39_RS15800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B4U39_RS15805	COG0193	aminoacyl-tRNA hydrolase activity
B4U39_RS15810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B4U39_RS15820	COG1309	transcriptional regulator
B4U39_RS15830	COG4106	trans-aconitate 2-methyltransferase activity
B4U39_RS15835	COG1846	Transcriptional regulator
B4U39_RS15840	COG2197	response regulator
B4U39_RS15865	COG0488	(ABC) transporter
B4U39_RS15875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4U39_RS15880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4U39_RS15885	COG3583	domain protein
B4U39_RS15885	COG3584	3D domain protein
B4U39_RS15890	COG0084	hydrolase, TatD family'
B4U39_RS15925	COG0442	prolyl-tRNA aminoacylation
B4U39_RS15930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U39_RS15935	COG1122	ATPase activity
B4U39_RS15945	COG0310	cobalt ion transport
B4U39_RS15955	COG2409	Drug exporters of the RND superfamily
B4U39_RS15965	COG4946	Tricorn protease homolog
B4U39_RS15965	COG0793	Belongs to the peptidase S41A family
B4U39_RS15970	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS15975	COG2267	carboxylic ester hydrolase activity
B4U39_RS15980	COG2072	flavoprotein involved in K transport
B4U39_RS15990	COG0708	Exodeoxyribonuclease III
B4U39_RS16025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U39_RS16030	COG0315	cyclic pyranopterin monophosphate synthase activity
B4U39_RS16030	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4U39_RS16035	COG0315	cyclic pyranopterin monophosphate synthase activity
B4U39_RS16045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U39_RS16050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4U39_RS16055	COG2366	antibiotic biosynthetic process
B4U39_RS16075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B4U39_RS16085	COG0284	orotidine-5'-phosphate decarboxylase activity
B4U39_RS16095	COG1970	mechanosensitive ion channel activity
B4U39_RS16140	COG0492	ferredoxin-NADP+ reductase activity
B4U39_RS16165	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS16185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4U39_RS16190	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS16255	COG1349	DNA-binding transcription factor activity
B4U39_RS16260	COG0477	Major facilitator Superfamily
B4U39_RS16275	COG3384	dioxygenase
B4U39_RS16320	COG0477	Major facilitator Superfamily
B4U39_RS16330	COG2267	carboxylic ester hydrolase activity
B4U39_RS16345	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS16350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U39_RS16360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS16370	COG0604	alcohol dehydrogenase
B4U39_RS16370	COG3321	synthase
B4U39_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS16395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS16400	COG3629	intracellular signal transduction
B4U39_RS16400	COG3903	Transcriptional regulator
B4U39_RS16405	COG0745	RESPONSE REGULATOR receiver
B4U39_RS16410	COG2205	protein histidine kinase activity
B4U39_RS16415	COG1136	(ABC) transporter
B4U39_RS16420	COG1136	(ABC) transporter
B4U39_RS16420	COG0577	efflux transmembrane transporter activity
B4U39_RS16465	COG1131	(ABC) transporter
B4U39_RS16480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4U39_RS16490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B4U39_RS16500	COG0602	queuosine metabolic process
B4U39_RS16505	COG0302	gtp cyclohydrolase
B4U39_RS16510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS16515	COG4865	methylaspartate mutase activity
B4U39_RS16535	COG0072	phenylalanine-tRNA ligase activity
B4U39_RS16535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U39_RS16555	COG2205	protein histidine kinase activity
B4U39_RS16620	COG3209	COG3209 Rhs family protein
B4U39_RS16635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B4U39_RS16640	COG2365	Tyrosine phosphatase family
B4U39_RS16700	COG4335	DNA alkylation repair
B4U39_RS16745	COG2205	protein histidine kinase activity
B4U39_RS16750	COG0745	RESPONSE REGULATOR receiver
B4U39_RS16765	COG1136	(ABC) transporter
B4U39_RS16765	COG0577	efflux transmembrane transporter activity
B4U39_RS16770	COG0577	efflux transmembrane transporter activity
B4U39_RS16770	COG1136	(ABC) transporter
B4U39_RS16775	COG0494	nUDIX hydrolase
B4U39_RS16845	COG1024	Enoyl-CoA hydratase
B4U39_RS16885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U39_RS16885	COG0515	serine threonine protein kinase
B4U39_RS16905	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS16910	COG0183	Belongs to the thiolase family
B4U39_RS16920	COG0259	pyridoxamine-phosphate oxidase activity
B4U39_RS16935	COG2072	flavoprotein involved in K transport
B4U39_RS16950	COG1024	Enoyl-CoA hydratase
B4U39_RS16960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4U39_RS16970	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS16975	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS17005	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS17010	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS17020	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS17085	COG1131	(ABC) transporter
B4U39_RS17110	COG4821	SIS domain
B4U39_RS17120	COG0259	pyridoxamine-phosphate oxidase activity
B4U39_RS17150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U39_RS17180	COG0277	FAD linked oxidase domain protein
B4U39_RS17180	COG0247	lactate metabolic process
B4U39_RS17185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4U39_RS17220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U39_RS17230	COG2252	PERMEase
B4U39_RS17255	COG1196	nuclear chromosome segregation
B4U39_RS17255	COG0741	lytic transglycosylase activity
B4U39_RS17255	COG0739	heme binding
B4U39_RS17270	COG0667	Aldo Keto reductase
B4U39_RS17285	COG2268	Band 7 protein
B4U39_RS17305	COG2814	Major facilitator Superfamily
B4U39_RS17315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4U39_RS17320	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B4U39_RS17325	COG1278	Cold shock
B4U39_RS17360	COG1061	Type III restriction enzyme res subunit
B4U39_RS17375	COG3973	AAA domain
B4U39_RS17400	COG3708	Transcriptional regulator
B4U39_RS17400	COG2207	Transcriptional regulator
B4U39_RS17415	COG1737	Transcriptional regulator
B4U39_RS17420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B4U39_RS17425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U39_RS17425	COG1263	PTS System
B4U39_RS17480	COG0135	phosphoribosylanthranilate isomerase activity
B4U39_RS17510	COG0463	Glycosyl transferase, family 2
B4U39_RS17520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U39_RS17520	COG0561	phosphatase activity
B4U39_RS17530	COG2182	Extracellular solute-binding protein
B4U39_RS17535	COG1940	carbohydrate kinase activity
B4U39_RS17540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4U39_RS17565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4U39_RS17730	COG4974	Belongs to the 'phage' integrase family
B4U39_RS17740	COG3842	ATPase activity
B4U39_RS17760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U39_RS17765	COG0215	cysteine-tRNA ligase activity
B4U39_RS17770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B4U39_RS17775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4U39_RS17780	COG1329	Transcriptional regulator
B4U39_RS17800	COG5002	protein histidine kinase activity
B4U39_RS17815	COG0588	phosphoglycerate mutase activity
B4U39_RS17830	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS17870	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U39_RS17875	COG4552	Acetyltransferase involved in intracellular survival and related
B4U39_RS17885	COG1490	D-aminoacyl-tRNA deacylase activity
B4U39_RS17895	COG0735	belongs to the Fur family
B4U39_RS17900	COG3485	protocatechuate 3,4-dioxygenase
B4U39_RS17930	COG2897	thiosulfate sulfurtransferase activity
B4U39_RS17955	COG0745	RESPONSE REGULATOR receiver
B4U39_RS17960	COG1609	Transcriptional regulator
B4U39_RS17970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U39_RS17975	COG0745	RESPONSE REGULATOR receiver
B4U39_RS17985	COG0823	Involved in the tonB-independent uptake of proteins
B4U39_RS17995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4U39_RS18000	COG0737	Belongs to the 5'-nucleotidase family
B4U39_RS18005	COG0456	acetyltransferase
B4U39_RS18040	COG0306	phosphate transporter
B4U39_RS18050	COG1937	Protein conserved in bacteria
B4U39_RS18070	COG0671	phosphoesterase, PA-phosphatase related
B4U39_RS18075	COG1196	nuclear chromosome segregation
B4U39_RS18075	COG0741	lytic transglycosylase activity
B4U39_RS18075	COG0739	heme binding
B4U39_RS18090	COG1280	lysine exporter protein (LysE YggA)
B4U39_RS18095	COG1357	PFAM Pentapeptide repeats (8 copies)
B4U39_RS18100	COG0596	Alpha beta hydrolase
B4U39_RS18250	COG1252	NADH dehydrogenase
B4U39_RS18295	COG0579	oxidoreductase
B4U39_RS18300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4U39_RS18310	COG1196	nuclear chromosome segregation
B4U39_RS18310	COG0741	lytic transglycosylase activity
B4U39_RS18310	COG0739	heme binding
B4U39_RS18360	COG0513	Belongs to the DEAD box helicase family
B4U39_RS18370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U39_RS18375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U39_RS18400	COG0785	Cytochrome C biogenesis protein
B4U39_RS18415	COG1643	Atp-dependent helicase
B4U39_RS18445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4U39_RS18455	COG3119	arylsulfatase activity
B4U39_RS18470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U39_RS18475	COG0047	phosphoribosylformylglycinamidine synthase activity
B4U39_RS18480	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U39_RS18500	COG1131	(ABC) transporter
B4U39_RS18510	COG3850	Histidine kinase
B4U39_RS18515	COG2197	response regulator
B4U39_RS18525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B4U39_RS18540	COG0151	Belongs to the GarS family
B4U39_RS18600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B4U39_RS18640	COG1191	sigma factor activity
B4U39_RS18655	COG1846	Transcriptional regulator
B4U39_RS18660	COG0477	Major facilitator Superfamily
B4U39_RS18680	COG2205	protein histidine kinase activity
B4U39_RS18685	COG0745	RESPONSE REGULATOR receiver
B4U39_RS18730	COG0546	phosphoglycolate phosphatase activity
B4U39_RS18825	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS18880	COG0629	single-stranded DNA binding
B4U39_RS19080	COG1595	DNA-templated transcription, initiation
B4U39_RS19095	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS19105	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS19130	COG2855	membrane
B4U39_RS19145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U39_RS19160	COG0653	protein targeting
B4U39_RS19180	COG0006	proline dipeptidase activity
B4U39_RS19200	COG1999	signal sequence binding
B4U39_RS19210	COG2372	response to copper ion
B4U39_RS19215	COG2837	iron assimilation
B4U39_RS19225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B4U39_RS19230	COG0561	phosphatase activity
B4U39_RS19245	COG2197	response regulator
B4U39_RS19270	COG1131	(ABC) transporter
B4U39_RS19290	COG0789	Transcriptional regulator
B4U39_RS19300	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B4U39_RS19305	COG0326	Molecular chaperone. Has ATPase activity
B4U39_RS19320	COG0561	phosphatase activity
B4U39_RS19330	COG4988	ABC transporter
B4U39_RS19335	COG1294	oxidase, subunit
B4U39_RS19340	COG1271	oxidase subunit
B4U39_RS19350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U39_RS19355	COG1609	Transcriptional regulator
B4U39_RS19370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B4U39_RS19395	COG0662	Cupin 2, conserved barrel domain protein
B4U39_RS19400	COG1950	PFAM Membrane protein of
B4U39_RS19405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U39_RS19410	COG0626	cystathionine gamma-synthase activity
B4U39_RS19420	COG0494	nUDIX hydrolase
B4U39_RS19455	COG0305	Participates in initiation and elongation during chromosome replication
B4U39_RS19460	COG0534	Mate efflux family protein
B4U39_RS19465	COG0359	binds to the 23S rRNA
B4U39_RS19470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B4U39_RS19475	COG0629	single-stranded DNA binding
B4U39_RS19480	COG0360	Binds together with S18 to 16S ribosomal RNA
B4U39_RS19505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U39_RS19515	COG1260	myo-inositol-1-phosphate synthase
B4U39_RS19525	COG0617	tRNA 3'-terminal CCA addition
B4U39_RS19540	COG0515	serine threonine protein kinase
B4U39_RS19540	COG2815	serine threonine protein kinase
B4U39_RS19545	COG1595	DNA-templated transcription, initiation
B4U39_RS19555	COG0492	ferredoxin-NADP+ reductase activity
B4U39_RS19560	COG3118	belongs to the thioredoxin family
B4U39_RS19575	COG1192	Involved in chromosome partitioning
B4U39_RS19580	COG0357	Ribosomal RNA small subunit methyltransferase G
B4U39_RS19590	COG0706	membrane insertase activity
B4U39_RS19595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4U39_RS19600	COG0594	ribonuclease P activity
B4U39_RS19605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B4U39_RS19610	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4U39_RS19620	COG0592	DNA-directed DNA polymerase activity
B4U39_RS19625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4U39_RS19630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4U39_RS19635	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B4U39_RS19645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U39_RS19670	COG0515	serine threonine protein kinase
B4U39_RS19710	COG0640	Transcriptional regulator
B4U39_RS19715	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS19715	COG0300	oxidoreductase activity
B4U39_RS19715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS19715	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS19715	COG3321	synthase
B4U39_RS19730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U39_RS19735	COG1834	amidinotransferase
B4U39_RS19750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U39_RS19750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U39_RS19760	COG0151	Belongs to the GarS family
B4U39_RS19765	COG1834	amidinotransferase
B4U39_RS19805	COG3903	Transcriptional regulator
B4U39_RS19805	COG3629	intracellular signal transduction
B4U39_RS19835	COG0457	Tetratricopeptide repeat
B4U39_RS19835	COG0705	Rhomboid family
B4U39_RS19850	COG3764	Sortase (surface protein transpeptidase)
B4U39_RS19860	COG3764	Sortase (surface protein transpeptidase)
B4U39_RS19865	COG3764	Sortase (surface protein transpeptidase)
B4U39_RS19870	COG0515	serine threonine protein kinase
B4U39_RS19880	COG0768	penicillin binding
B4U39_RS19895	COG1716	ATPase activity
B4U39_RS19900	COG1716	ATPase activity
B4U39_RS19910	COG4585	Histidine kinase
B4U39_RS19915	COG2197	response regulator
B4U39_RS19940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4U39_RS19945	COG2151	metal-sulfur cluster biosynthetic enzyme
B4U39_RS19950	COG3396	Phenylacetate-CoA oxygenase
B4U39_RS19955	COG3460	Phenylacetate-CoA oxygenase
B4U39_RS19960	COG3396	Phenylacetate-CoA oxygenase
B4U39_RS19990	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U39_RS19995	COG1309	transcriptional regulator
B4U39_RS20000	COG1522	sequence-specific DNA binding
B4U39_RS20020	COG3321	synthase
B4U39_RS20020	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS20020	COG0604	alcohol dehydrogenase
B4U39_RS20025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4U39_RS20050	COG4591	ABC-type transport system involved in lipoprotein release permease component
B4U39_RS20050	COG1136	(ABC) transporter
B4U39_RS20065	COG0515	serine threonine protein kinase
B4U39_RS20070	COG0515	serine threonine protein kinase
B4U39_RS20090	COG0022	dehydrogenase e1 component
B4U39_RS20095	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U39_RS20155	COG2271	Major facilitator Superfamily
B4U39_RS20200	COG1362	aminopeptidase activity
B4U39_RS20210	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS20240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B4U39_RS20255	COG2205	protein histidine kinase activity
B4U39_RS20265	COG1289	transmembrane transporter activity
B4U39_RS20360	COG1278	Cold shock
B4U39_RS20390	COG0277	FAD linked oxidase domain protein
B4U39_RS20400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4U39_RS20520	COG1595	DNA-templated transcription, initiation
B4U39_RS20570	COG0717	Belongs to the dCTP deaminase family
B4U39_RS20595	COG2181	nitrate reductase activity
B4U39_RS20595	COG0247	lactate metabolic process
B4U39_RS20605	COG0443	Heat shock 70 kDa protein
B4U39_RS20610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4U39_RS20615	COG0484	heat shock protein binding
B4U39_RS20620	COG0789	Transcriptional regulator
B4U39_RS20645	COG0542	response to heat
B4U39_RS20675	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4U39_RS20690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4U39_RS20695	COG0191	fructose-bisphosphate aldolase activity
B4U39_RS20725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U39_RS20745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B4U39_RS20760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4U39_RS20765	COG0346	lactoylglutathione lyase activity
B4U39_RS20780	COG1131	(ABC) transporter
B4U39_RS20785	COG3559	Exporter of polyketide antibiotics
B4U39_RS20795	COG2197	response regulator
B4U39_RS20800	COG4585	Histidine kinase
B4U39_RS20805	COG2197	response regulator
B4U39_RS20810	COG4585	Histidine kinase
B4U39_RS20830	COG1652	LysM domain
B4U39_RS20840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U39_RS20840	COG0515	serine threonine protein kinase
B4U39_RS20850	COG0693	protein deglycase activity
B4U39_RS20855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B4U39_RS20875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4U39_RS20880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B4U39_RS20900	COG1595	DNA-templated transcription, initiation
B4U39_RS20920	COG0402	S-adenosylhomocysteine deaminase activity
B4U39_RS20955	COG3409	Peptidoglycan-binding domain 1 protein
B4U39_RS20960	COG0577	efflux transmembrane transporter activity
B4U39_RS20960	COG1136	(ABC) transporter
B4U39_RS20965	COG1136	(ABC) transporter
B4U39_RS20995	COG1408	metallophosphoesterase
B4U39_RS21005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B4U39_RS21020	COG0003	Pfam Anion-transporting ATPase
B4U39_RS21040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U39_RS21075	COG2267	carboxylic ester hydrolase activity
B4U39_RS21085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B4U39_RS21090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U39_RS21155	COG1205	dead DEAH box helicase
B4U39_RS21155	COG1111	helicase
B4U39_RS21160	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U39_RS21170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B4U39_RS21180	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U39_RS21190	COG1754	DNA topoisomerase type I activity
B4U39_RS21190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U39_RS21195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4U39_RS21200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4U39_RS21245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U39_RS21245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U39_RS21255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U39_RS21280	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS21285	COG0768	penicillin binding
B4U39_RS21290	COG2318	DinB family
B4U39_RS21310	COG0789	Transcriptional regulator
B4U39_RS21315	COG0586	Pfam SNARE associated Golgi protein
B4U39_RS21325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B4U39_RS21330	COG2027	D-alanyl-D-alanine carboxypeptidase
B4U39_RS21340	COG0037	tRNA processing
B4U39_RS21345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B4U39_RS21355	COG0302	gtp cyclohydrolase
B4U39_RS21365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4U39_RS21370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4U39_RS21385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4U39_RS21385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U39_RS21400	COG1174	glycine betaine transport
B4U39_RS21410	COG1732	Glycine betaine
B4U39_RS21430	COG0649	NAD binding
B4U39_RS21445	COG2197	response regulator
B4U39_RS21465	COG0640	Transcriptional regulator
B4U39_RS21475	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B4U39_RS21485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4U39_RS21490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B4U39_RS21520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B4U39_RS21545	COG0739	heme binding
B4U39_RS21555	COG2205	protein histidine kinase activity
B4U39_RS21560	COG0745	RESPONSE REGULATOR receiver
B4U39_RS21570	COG1595	DNA-templated transcription, initiation
B4U39_RS21575	COG1194	a g-specific adenine glycosylase
B4U39_RS21590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B4U39_RS21610	COG0248	Ppx GppA phosphatase
B4U39_RS21620	COG1082	Xylose isomerase domain protein TIM barrel
B4U39_RS21630	COG0129	dihydroxy-acid dehydratase activity
B4U39_RS21635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U39_RS21635	COG0515	serine threonine protein kinase
B4U39_RS21640	COG4991	sh3 domain protein
B4U39_RS21650	COG0842	Transport permease protein
B4U39_RS21650	COG1129	ABC transporter
B4U39_RS21660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U39_RS21665	COG0180	Tryptophanyl-tRNA synthetase
B4U39_RS21690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U39_RS21700	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4U39_RS21750	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B4U39_RS21755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B4U39_RS21760	COG0181	hydroxymethylbilane synthase activity
B4U39_RS21765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4U39_RS21765	COG1648	precorrin-2 dehydrogenase activity
B4U39_RS21770	COG4977	sequence-specific DNA binding
B4U39_RS21780	COG0113	porphobilinogen synthase activity
B4U39_RS21870	COG0018	arginyl-trna synthetase
B4U39_RS21875	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B4U39_RS21895	COG1690	Belongs to the RtcB family
B4U39_RS21915	COG0726	polysaccharide deacetylase
B4U39_RS21935	COG1733	regulation of RNA biosynthetic process
B4U39_RS21940	COG0604	alcohol dehydrogenase
B4U39_RS21940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS21940	COG3321	synthase
B4U39_RS21940	COG4221	oxidoreductase activity
B4U39_RS22015	COG0464	growth
B4U39_RS22025	COG4946	Tricorn protease homolog
B4U39_RS22025	COG0793	Belongs to the peptidase S41A family
B4U39_RS22030	COG2197	response regulator
B4U39_RS22050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U39_RS22055	COG0406	alpha-ribazole phosphatase activity
B4U39_RS22070	COG0785	Cytochrome C biogenesis protein
B4U39_RS22075	COG1333	cytochrome c biogenesis protein
B4U39_RS22080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4U39_RS22090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4U39_RS22105	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B4U39_RS22115	COG0109	protoheme IX farnesyltransferase activity
B4U39_RS22125	COG0163	prenyltransferase activity
B4U39_RS22135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B4U39_RS22150	COG1301	dicarboxylic acid transport
B4U39_RS22225	COG1278	Cold shock
B4U39_RS22230	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B4U39_RS22235	COG0515	serine threonine protein kinase
B4U39_RS22235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U39_RS22240	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B4U39_RS22250	COG2197	response regulator
B4U39_RS22260	COG2226	methyltransferase
B4U39_RS22265	COG2066	Belongs to the glutaminase family
B4U39_RS22285	COG0577	efflux transmembrane transporter activity
B4U39_RS22290	COG0577	efflux transmembrane transporter activity
B4U39_RS22290	COG1136	(ABC) transporter
B4U39_RS22325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS22330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS22335	COG0649	NAD binding
B4U39_RS22345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B4U39_RS22350	COG1034	ATP synthesis coupled electron transport
B4U39_RS22355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B4U39_RS22360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS22365	COG0839	Belongs to the complex I subunit 6 family
B4U39_RS22370	COG0713	ATP synthesis coupled electron transport
B4U39_RS22375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U39_RS22385	COG1007	ATP synthesis coupled electron transport
B4U39_RS22400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4U39_RS22410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U39_RS22425	COG2188	Transcriptional regulator
B4U39_RS22435	COG0561	phosphatase activity
B4U39_RS22445	COG3104	oligopeptide transport
B4U39_RS22450	COG0142	geranyltranstransferase activity
B4U39_RS22480	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4U39_RS22485	COG0674	pyruvate-flavodoxin oxidoreductase activity
B4U39_RS22485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B4U39_RS22505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS22510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS22515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS22520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B4U39_RS22525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U39_RS22530	COG0839	Belongs to the complex I subunit 6 family
B4U39_RS22535	COG0713	ATP synthesis coupled electron transport
B4U39_RS22540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U39_RS22550	COG1007	ATP synthesis coupled electron transport
B4U39_RS22555	COG0501	Belongs to the peptidase M48B family
B4U39_RS22560	COG3304	Inner membrane component domain
B4U39_RS22580	COG0659	secondary active sulfate transmembrane transporter activity
B4U39_RS22585	COG1666	GTP binding
B4U39_RS22605	COG0702	epimerase
B4U39_RS22625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4U39_RS22630	COG2030	dehydratase
B4U39_RS22650	COG0477	Major facilitator Superfamily
B4U39_RS22660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4U39_RS22670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B4U39_RS22675	COG0436	Aminotransferase
B4U39_RS22685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U39_RS22695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B4U39_RS22700	COG0081	regulation of translation
B4U39_RS22715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4U39_RS22720	COG0222	ribosome binding
B4U39_RS22730	COG0085	RNA polymerase activity
B4U39_RS22735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4U39_RS22745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4U39_RS22750	COG0049	tRNA binding
B4U39_RS22755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4U39_RS22760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4U39_RS22790	COG1216	Glycosyl transferase, family 2
B4U39_RS22815	COG0051	transcription antitermination factor activity, RNA binding
B4U39_RS22820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4U39_RS22825	COG0088	Forms part of the polypeptide exit tunnel
B4U39_RS22830	COG0089	rRNA binding
B4U39_RS22835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B4U39_RS22840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B4U39_RS22845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B4U39_RS22850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B4U39_RS22855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4U39_RS22860	COG0255	Belongs to the universal ribosomal protein uL29 family
B4U39_RS22865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4U39_RS22870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B4U39_RS22875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B4U39_RS22880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B4U39_RS22885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U39_RS22895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4U39_RS22900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4U39_RS22905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B4U39_RS22910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4U39_RS22915	COG1841	ribosomal large subunit assembly
B4U39_RS22920	COG0200	Binds to the 23S rRNA
B4U39_RS22925	COG0201	protein transport
B4U39_RS22930	COG0563	adenylate kinase activity
B4U39_RS22940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B4U39_RS22945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4U39_RS22950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4U39_RS22955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B4U39_RS22960	COG0202	RNA polymerase activity
B4U39_RS22965	COG0203	ribosomal protein L17
B4U39_RS22970	COG0101	tRNA pseudouridine synthase activity
B4U39_RS22975	COG0488	(ABC) transporter
B4U39_RS22985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4U39_RS22990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4U39_RS22995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U39_RS23005	COG1072	(Pantothenic acid kinase))
B4U39_RS23015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4U39_RS23020	COG0736	holo-[acyl-carrier-protein] synthase activity
B4U39_RS23030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4U39_RS23040	COG0802	atpase or kinase
B4U39_RS23060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B4U39_RS23075	COG0726	polysaccharide deacetylase
B4U39_RS23080	COG0726	polysaccharide deacetylase
B4U39_RS23095	COG0772	Belongs to the SEDS family
B4U39_RS23100	COG1316	TRANSCRIPTIONal
B4U39_RS23105	COG2205	protein histidine kinase activity
B4U39_RS23115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B4U39_RS23120	COG0459	protein refolding
B4U39_RS23130	COG4221	oxidoreductase activity
B4U39_RS23140	COG0583	DNA-binding transcription factor activity
B4U39_RS23155	COG1595	DNA-templated transcription, initiation
B4U39_RS23165	COG0516	GMP reductase activity
B4U39_RS23180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4U39_RS23185	COG0515	serine threonine protein kinase
B4U39_RS23195	COG0515	serine threonine protein kinase
B4U39_RS23200	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS23220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4U39_RS23220	COG0519	Catalyzes the synthesis of GMP from XMP
B4U39_RS23255	COG2197	response regulator
B4U39_RS23275	COG0640	Transcriptional regulator
B4U39_RS23295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS23295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS23310	COG0714	Associated with various cellular activities
B4U39_RS23320	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B4U39_RS23325	COG0045	succinate-CoA ligase (ADP-forming) activity
B4U39_RS23355	COG0138	bifunctional purine biosynthesis protein purh
B4U39_RS23365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4U39_RS23380	COG0039	L-malate dehydrogenase activity
B4U39_RS23400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4U39_RS23405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U39_RS23420	COG0754	glutathionylspermidine amidase activity
B4U39_RS23425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U39_RS23430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4U39_RS23435	COG0180	Tryptophanyl-tRNA synthetase
B4U39_RS23445	COG1295	ribonuclease BN
B4U39_RS23460	COG1686	Belongs to the peptidase S11 family
B4U39_RS23470	COG1408	metallophosphoesterase
B4U39_RS23480	COG1309	transcriptional regulator
B4U39_RS23495	COG0596	Alpha beta hydrolase
B4U39_RS23515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4U39_RS23520	COG1053	succinate dehydrogenase
B4U39_RS23530	COG2009	succinate dehydrogenase
B4U39_RS23540	COG1595	DNA-templated transcription, initiation
B4U39_RS23555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS23555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS23570	COG1216	Glycosyl transferase, family 2
B4U39_RS23580	COG2089	acid synthase
B4U39_RS23590	COG1473	amidohydrolase
B4U39_RS23590	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B4U39_RS23595	COG1744	ABC transporter substrate-binding protein PnrA-like
B4U39_RS23600	COG3845	ABC transporter
B4U39_RS23605	COG4603	Belongs to the binding-protein-dependent transport system permease family
B4U39_RS23610	COG1079	Belongs to the binding-protein-dependent transport system permease family
B4U39_RS23655	COG2814	Major facilitator Superfamily
B4U39_RS23660	COG0583	DNA-binding transcription factor activity
B4U39_RS23665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U39_RS23685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B4U39_RS23730	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS23735	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS23760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U39_RS23775	COG1595	DNA-templated transcription, initiation
B4U39_RS23780	COG0745	RESPONSE REGULATOR receiver
B4U39_RS23785	COG2205	protein histidine kinase activity
B4U39_RS23795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U39_RS23820	COG4770	biotin carboxylase activity
B4U39_RS23870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U39_RS23880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS23885	COG0515	serine threonine protein kinase
B4U39_RS23900	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS23905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U39_RS23915	COG1819	glycosyl
B4U39_RS23930	COG2226	methyltransferase
B4U39_RS23940	COG0424	maF-like protein
B4U39_RS23950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U39_RS23965	COG1024	Enoyl-CoA hydratase
B4U39_RS23975	COG2986	histidine ammonia-lyase
B4U39_RS23990	COG1376	ErfK ybiS ycfS ynhG family protein
B4U39_RS23995	COG0456	acetyltransferase
B4U39_RS24000	COG3119	arylsulfatase activity
B4U39_RS24005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U39_RS24035	COG1595	DNA-templated transcription, initiation
B4U39_RS24045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4U39_RS24060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4U39_RS24070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U39_RS24090	COG1331	Highly conserved protein containing a thioredoxin domain
B4U39_RS24105	COG0463	Glycosyl transferase, family 2
B4U39_RS24120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B4U39_RS24135	COG3853	Toxic anion resistance protein (TelA)
B4U39_RS24160	COG0436	Aminotransferase
B4U39_RS24210	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B4U39_RS24220	COG1414	Transcriptional regulator
B4U39_RS24250	COG2894	cell division
B4U39_RS24300	COG2885	chlorophyll binding
B4U39_RS24310	COG1309	transcriptional regulator
B4U39_RS24370	COG0667	Aldo Keto reductase
B4U39_RS24375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4U39_RS24380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4U39_RS24405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4U39_RS24410	COG0450	alkyl hydroperoxide reductase
B4U39_RS24425	COG1136	(ABC) transporter
B4U39_RS24445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U39_RS24460	COG0114	fumarate hydratase activity
B4U39_RS24485	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B4U39_RS24485	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B4U39_RS24515	COG3415	Transposase
B4U39_RS24515	COG2801	Transposase and inactivated derivatives
B4U39_RS24525	COG0778	Nitroreductase
B4U39_RS24530	COG1722	exodeoxyribonuclease VII activity
B4U39_RS24535	COG1570	exodeoxyribonuclease VII activity
B4U39_RS24545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B4U39_RS24560	COG0012	GTP binding
B4U39_RS24580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4U39_RS24615	COG0697	spore germination
B4U39_RS24620	COG2224	Isocitrate lyase
B4U39_RS24665	COG1842	Phage shock protein A
B4U39_RS24685	COG1053	succinate dehydrogenase
B4U39_RS24705	COG1217	gtp-binding protein TYPA
B4U39_RS24710	COG4166	transmembrane transport
B4U39_RS24715	COG0601	transmembrane transport
B4U39_RS24720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U39_RS24730	COG4608	Belongs to the ABC transporter superfamily
B4U39_RS24740	COG4166	transmembrane transport
B4U39_RS24745	COG0601	transmembrane transport
B4U39_RS24750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U39_RS24755	COG0444	Belongs to the ABC transporter superfamily
B4U39_RS24760	COG4608	Belongs to the ABC transporter superfamily
B4U39_RS24770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U39_RS24790	COG1131	(ABC) transporter
B4U39_RS24800	COG4585	Histidine kinase
B4U39_RS24805	COG2197	response regulator
B4U39_RS24840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U39_RS24845	COG1611	Belongs to the LOG family
B4U39_RS24850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4U39_RS24860	COG2818	Glycosylase
B4U39_RS24865	COG1024	Enoyl-CoA hydratase
B4U39_RS24885	COG1595	DNA-templated transcription, initiation
B4U39_RS24895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U39_RS24900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U39_RS24935	COG0598	Magnesium transport protein CorA
B4U39_RS24955	COG2095	MarC family integral membrane protein
B4U39_RS24960	COG2267	carboxylic ester hydrolase activity
B4U39_RS25010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U39_RS25015	COG0601	transmembrane transport
B4U39_RS25070	COG0210	DNA helicase
B4U39_RS25075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U39_RS25115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B4U39_RS25170	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4U39_RS25180	COG1615	UPF0182 protein
B4U39_RS25195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U39_RS25215	COG0753	catalase activity
B4U39_RS25225	COG0483	inositol monophosphate 1-phosphatase activity
B4U39_RS25235	COG2076	Multidrug Resistance protein
B4U39_RS25245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4U39_RS25255	COG2135	peptidase activity
B4U39_RS25265	COG1595	DNA-templated transcription, initiation
B4U39_RS25270	COG5662	AntiSigma factor
B4U39_RS25275	COG2199	diguanylate cyclase activity
B4U39_RS25275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B4U39_RS25290	COG0242	peptide deformylase activity
B4U39_RS25325	COG1966	Carbon starvation protein
B4U39_RS25330	COG2188	Transcriptional regulator
B4U39_RS25335	COG2182	Extracellular solute-binding protein
B4U39_RS25340	COG1175	transmembrane transport
B4U39_RS25345	COG0395	ABC-type sugar transport system, permease component
B4U39_RS25350	COG1472	Belongs to the glycosyl hydrolase 3 family
B4U39_RS25355	COG0363	glucosamine-6-phosphate deaminase activity
B4U39_RS25360	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS25365	COG1309	transcriptional regulator
B4U39_RS25410	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B4U39_RS25420	COG1017	nitric oxide dioxygenase activity
B4U39_RS25420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4U39_RS25425	COG1959	2 iron, 2 sulfur cluster binding
B4U39_RS25430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U39_RS25435	COG0142	geranyltranstransferase activity
B4U39_RS25460	COG0583	DNA-binding transcription factor activity
B4U39_RS25490	COG0604	alcohol dehydrogenase
B4U39_RS25495	COG0281	malic enzyme
B4U39_RS25510	COG0765	amino acid transport
B4U39_RS25515	COG1126	abc transporter atp-binding protein
B4U39_RS25520	COG4106	trans-aconitate 2-methyltransferase activity
B4U39_RS25620	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B4U39_RS25625	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U39_RS25625	COG0567	Dehydrogenase, E1 component
B4U39_RS25630	COG2205	protein histidine kinase activity
B4U39_RS25635	COG0745	RESPONSE REGULATOR receiver
B4U39_RS25660	COG2897	thiosulfate sulfurtransferase activity
B4U39_RS25670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4U39_RS25685	COG5002	protein histidine kinase activity
B4U39_RS25710	COG1388	LysM domain
B4U39_RS25710	COG3103	Sh3 type 3 domain protein
B4U39_RS25710	COG0791	NLP P60 protein
B4U39_RS25715	COG1595	DNA-templated transcription, initiation
B4U39_RS25720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4U39_RS25735	COG0772	Belongs to the SEDS family
B4U39_RS25755	COG1309	transcriptional regulator
B4U39_RS25765	COG2205	protein histidine kinase activity
B4U39_RS25785	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B4U39_RS25790	COG1793	dna ligase
B4U39_RS25790	COG3285	dna ligase
B4U39_RS25795	COG1793	dna ligase
B4U39_RS25815	COG3608	succinylglutamate desuccinylase aspartoacylase
B4U39_RS25815	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B4U39_RS25885	COG2188	Transcriptional regulator
B4U39_RS25915	COG2188	Transcriptional regulator
B4U39_RS25975	COG0018	arginyl-trna synthetase
B4U39_RS25980	COG0019	diaminopimelate decarboxylase activity
B4U39_RS25985	COG0460	homoserine dehydrogenase
B4U39_RS25990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4U39_RS25995	COG0083	homoserine kinase activity
B4U39_RS26005	COG1316	TRANSCRIPTIONal
B4U39_RS26010	COG0254	rRNA binding
B4U39_RS26015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4U39_RS26020	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U39_RS26030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U39_RS26035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4U39_RS26055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U39_RS26060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B4U39_RS26065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U39_RS26070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4U39_RS26075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4U39_RS26080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4U39_RS26085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B4U39_RS26100	COG2197	response regulator
B4U39_RS26130	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U39_RS26145	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B4U39_RS26200	COG0183	Belongs to the thiolase family
B4U39_RS26285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS26285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS26325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B4U39_RS26330	COG0857	belongs to the CobB CobQ family
B4U39_RS26330	COG0280	phosphate acetyltransferase
B4U39_RS26335	COG0205	6-phosphofructokinase activity
B4U39_RS26365	COG0366	Alpha amylase catalytic
B4U39_RS26370	COG0366	Alpha amylase catalytic
B4U39_RS26375	COG0058	SHG alpha-glucan phosphorylase activity
B4U39_RS26390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4U39_RS26395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U39_RS26400	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B4U39_RS26440	COG0489	protein tyrosine kinase activity
B4U39_RS26445	COG0297	glycogen (starch) synthase activity
B4U39_RS26530	COG1760	l-serine dehydratase
B4U39_RS26535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4U39_RS26540	COG0509	glycine decarboxylation via glycine cleavage system
B4U39_RS26545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B4U39_RS26565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U39_RS26570	COG0747	negative chemotaxis
B4U39_RS26580	COG0444	Belongs to the ABC transporter superfamily
B4U39_RS26585	COG4608	Belongs to the ABC transporter superfamily
B4U39_RS26590	COG2860	membrane
B4U39_RS26610	COG0482	sulfurtransferase activity
B4U39_RS26630	COG4977	sequence-specific DNA binding
B4U39_RS26655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B4U39_RS26665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U39_RS26670	COG0154	amidase activity
B4U39_RS26680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U39_RS26690	COG0515	serine threonine protein kinase
B4U39_RS26690	COG2815	serine threonine protein kinase
B4U39_RS26705	COG2375	cellular response to nickel ion
B4U39_RS26705	COG1132	(ABC) transporter
B4U39_RS26735	COG1660	Displays ATPase and GTPase activities
B4U39_RS26760	COG0494	nUDIX hydrolase
B4U39_RS26840	COG2318	DinB family
B4U39_RS26855	COG2409	Drug exporters of the RND superfamily
B4U39_RS26870	COG2197	response regulator
B4U39_RS26880	COG2133	pyrroloquinoline quinone binding
B4U39_RS26885	COG0667	Aldo Keto reductase
B4U39_RS26905	COG0440	acetolactate synthase activity
B4U39_RS26910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4U39_RS26920	COG0477	Major facilitator Superfamily
B4U39_RS26930	COG3835	regulator
B4U39_RS26935	COG0506	proline dehydrogenase activity
B4U39_RS26940	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS26955	COG3511	phospholipase C
B4U39_RS26960	COG2130	NADP-dependent
B4U39_RS26965	COG0583	DNA-binding transcription factor activity
B4U39_RS26970	COG0473	3-isopropylmalate dehydrogenase activity
B4U39_RS26975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U39_RS26985	COG0831	urea catabolic process
B4U39_RS26985	COG0832	Belongs to the urease beta subunit family
B4U39_RS26990	COG0804	urea catabolic process
B4U39_RS26995	COG2957	Belongs to the agmatine deiminase family
B4U39_RS27005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U39_RS27015	COG2353	YceI-like domain
B4U39_RS27020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U39_RS27040	COG2018	Roadblock/LC7 domain
B4U39_RS27060	COG2018	Roadblock/LC7 domain
B4U39_RS27065	COG5002	protein histidine kinase activity
B4U39_RS27075	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U39_RS27080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4U39_RS27125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4U39_RS27130	COG0066	3-isopropylmalate dehydratase activity
B4U39_RS27140	COG0776	regulation of translation
B4U39_RS27145	COG1920	GTP binding
B4U39_RS27155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B4U39_RS27160	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U39_RS27180	COG0351	phosphomethylpyrimidine kinase
B4U39_RS27185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4U39_RS27190	COG1461	Dihydroxyacetone kinase
B4U39_RS27195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4U39_RS27200	COG0742	ribosomal rna small subunit methyltransferase
B4U39_RS27205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4U39_RS27220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B4U39_RS27225	COG0571	ribonuclease III activity
B4U39_RS27230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4U39_RS27235	COG1733	regulation of RNA biosynthetic process
B4U39_RS27250	COG1254	Belongs to the acylphosphatase family
B4U39_RS27260	COG1196	nuclear chromosome segregation
B4U39_RS27265	COG0477	Major facilitator Superfamily
B4U39_RS27270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS27305	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B4U39_RS27315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4U39_RS27325	COG0442	prolyl-tRNA aminoacylation
B4U39_RS27340	COG0228	four-way junction DNA binding
B4U39_RS27345	COG1837	Belongs to the UPF0109 family
B4U39_RS27350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4U39_RS27355	COG0336	Belongs to the RNA methyltransferase TrmD family
B4U39_RS27360	COG0335	large ribosomal subunit rRNA binding
B4U39_RS27375	COG0681	Belongs to the peptidase S26 family
B4U39_RS27380	COG0681	Belongs to the peptidase S26 family
B4U39_RS27395	COG0792	nuclease activity
B4U39_RS27410	COG1191	sigma factor activity
B4U39_RS27425	COG0052	Belongs to the universal ribosomal protein uS2 family
B4U39_RS27430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B4U39_RS27435	COG0528	UMP kinase activity
B4U39_RS27440	COG0233	cytoplasmic translational termination
B4U39_RS27450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4U39_RS27465	COG3842	ATPase activity
B4U39_RS27475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U39_RS27510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U39_RS27520	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS27540	COG2197	response regulator
B4U39_RS27545	COG4585	Histidine kinase
B4U39_RS27555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B4U39_RS27570	COG0494	nUDIX hydrolase
B4U39_RS27585	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4U39_RS27590	COG3842	ATPase activity
B4U39_RS27595	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4U39_RS27600	COG1177	transmembrane transport
B4U39_RS27605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U39_RS27635	COG2508	Transcriptional regulator
B4U39_RS27640	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS27660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B4U39_RS27665	COG0750	zinc metalloprotease
B4U39_RS27670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4U39_RS27685	COG0442	prolyl-tRNA aminoacylation
B4U39_RS27690	COG0330	HflC and HflK could
B4U39_RS27710	COG0779	Required for maturation of 30S ribosomal subunits
B4U39_RS27725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B4U39_RS27735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B4U39_RS27740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4U39_RS27755	COG0455	bacterial-type flagellum organization
B4U39_RS27775	COG1404	Belongs to the peptidase S8 family
B4U39_RS27795	COG1674	ftsk spoiiie
B4U39_RS27805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4U39_RS27810	COG1185	polyribonucleotide nucleotidyltransferase activity
B4U39_RS27815	COG0612	Peptidase, M16
B4U39_RS27820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4U39_RS27840	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B4U39_RS27845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4U39_RS27850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U39_RS27885	COG2770	Histidine kinase
B4U39_RS27885	COG2208	phosphoserine phosphatase activity
B4U39_RS27895	COG4999	Histidine kinase
B4U39_RS27895	COG3437	response regulator, receiver
B4U39_RS27895	COG3850	Histidine kinase
B4U39_RS27895	COG2205	protein histidine kinase activity
B4U39_RS27905	COG1674	ftsk spoiiie
B4U39_RS27915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U39_RS27925	COG1058	Belongs to the CinA family
B4U39_RS27925	COG1546	Belongs to the CinA family
B4U39_RS27930	COG1396	sequence-specific DNA binding
B4U39_RS27940	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS27945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4U39_RS27950	COG1201	RNA secondary structure unwinding
B4U39_RS27955	COG1917	Cupin 2, conserved barrel domain protein
B4U39_RS27955	COG2207	Transcriptional regulator
B4U39_RS27990	COG2226	methyltransferase
B4U39_RS28005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B4U39_RS28030	COG0765	amino acid transport
B4U39_RS28035	COG0765	amino acid transport
B4U39_RS28040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U39_RS28045	COG1126	abc transporter atp-binding protein
B4U39_RS28055	COG2205	protein histidine kinase activity
B4U39_RS28080	COG1609	Transcriptional regulator
B4U39_RS28095	COG0583	DNA-binding transcription factor activity
B4U39_RS28105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U39_RS28120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B4U39_RS28130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B4U39_RS28135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U39_RS28145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4U39_RS28180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4U39_RS28185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4U39_RS28190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U39_RS28210	COG0406	alpha-ribazole phosphatase activity
B4U39_RS28235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4U39_RS28280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4U39_RS28305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U39_RS28310	COG4565	transcriptional regulatory protein
B4U39_RS28315	COG3290	protein histidine kinase activity
B4U39_RS28325	COG0372	Belongs to the citrate synthase family
B4U39_RS28340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U39_RS28345	COG0612	Peptidase, M16
B4U39_RS28360	COG1802	Transcriptional regulator
B4U39_RS28365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U39_RS28385	COG1435	thymidine kinase activity
B4U39_RS28390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4U39_RS28435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B4U39_RS28440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U39_RS28485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B4U39_RS28500	COG0745	RESPONSE REGULATOR receiver
B4U39_RS28505	COG2205	protein histidine kinase activity
B4U39_RS28530	COG0756	dUTP diphosphatase activity
B4U39_RS28565	COG0569	domain protein
B4U39_RS28570	COG0531	amino acid
B4U39_RS28575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4U39_RS28610	COG1051	belongs to the nudix hydrolase family
B4U39_RS28650	COG2124	cytochrome p450
B4U39_RS28655	COG2124	cytochrome p450
B4U39_RS28660	COG0644	oxidoreductase
B4U39_RS28705	COG0604	alcohol dehydrogenase
B4U39_RS28705	COG3321	synthase
B4U39_RS28740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B4U39_RS28745	COG2409	Drug exporters of the RND superfamily
B4U39_RS28755	COG0252	asparaginase activity
B4U39_RS28795	COG0431	NADPH-dependent FMN reductase
B4U39_RS28815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS28820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4U39_RS28840	COG1799	cell septum assembly
B4U39_RS28890	COG2040	homocysteine
B4U39_RS28900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4U39_RS28915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4U39_RS28925	COG1024	Enoyl-CoA hydratase
B4U39_RS28970	COG0745	RESPONSE REGULATOR receiver
B4U39_RS28975	COG2205	protein histidine kinase activity
B4U39_RS28980	COG0006	proline dipeptidase activity
B4U39_RS28990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U39_RS29010	COG3938	Belongs to the proline racemase family
B4U39_RS29035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U39_RS29045	COG0444	Belongs to the ABC transporter superfamily
B4U39_RS29050	COG4608	Belongs to the ABC transporter superfamily
B4U39_RS29055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U39_RS29090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U39_RS29105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4U39_RS29110	COG1653	transport
B4U39_RS29115	COG1175	transmembrane transport
B4U39_RS29120	COG0395	ABC-type sugar transport system, permease component
B4U39_RS29140	COG1940	carbohydrate kinase activity
B4U39_RS29145	COG4213	ABC transporter substrate-binding protein
B4U39_RS29155	COG4214	carbohydrate transport
B4U39_RS29160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B4U39_RS29165	COG0531	amino acid
B4U39_RS29170	COG1316	TRANSCRIPTIONal
B4U39_RS29175	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U39_RS29175	COG1024	Enoyl-CoA hydratase
B4U39_RS29180	COG0183	Belongs to the thiolase family
B4U39_RS29190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B4U39_RS29205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4U39_RS29215	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4U39_RS29225	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4U39_RS29230	COG3253	May function as heme-dependent peroxidase
B4U39_RS29235	COG0596	Alpha beta hydrolase
B4U39_RS29245	COG3220	belongs to the UPF0276 family
B4U39_RS29260	COG1116	anion transmembrane transporter activity
B4U39_RS29305	COG1122	ATPase activity
B4U39_RS29325	COG2326	polyphosphate kinase activity
B4U39_RS29370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4U39_RS29375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U39_RS29475	COG3511	phospholipase C
B4U39_RS29505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B4U39_RS29520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U39_RS29525	COG0583	DNA-binding transcription factor activity
B4U39_RS29595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U39_RS29600	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B4U39_RS29620	COG0529	Catalyzes the synthesis of activated sulfate
B4U39_RS29625	COG0175	sulfate reduction
B4U39_RS29640	COG0456	acetyltransferase
B4U39_RS29650	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS29680	COG1162	GTPase activity
B4U39_RS29685	COG2205	protein histidine kinase activity
B4U39_RS29705	COG1404	Belongs to the peptidase S8 family
B4U39_RS29740	COG1802	Transcriptional regulator
B4U39_RS29750	COG3835	regulator
B4U39_RS29770	COG2252	PERMEase
B4U39_RS29795	COG4552	Acetyltransferase involved in intracellular survival and related
B4U39_RS29835	COG1309	transcriptional regulator
B4U39_RS29905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U39_RS29910	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS29915	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS29920	COG3321	synthase
B4U39_RS29920	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS29920	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS29920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS29920	COG0300	oxidoreductase activity
B4U39_RS29930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS29965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4U39_RS29980	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS29990	COG3629	intracellular signal transduction
B4U39_RS29990	COG3903	Transcriptional regulator
B4U39_RS30000	COG2211	Major facilitator Superfamily
B4U39_RS30050	COG0463	Glycosyl transferase, family 2
B4U39_RS30090	COG0463	Glycosyl transferase, family 2
B4U39_RS30115	COG1088	dTDP-glucose 4,6-dehydratase activity
B4U39_RS30140	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS30150	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS30160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4U39_RS30160	COG1024	Enoyl-CoA hydratase
B4U39_RS30200	COG0375	protein maturation
B4U39_RS30210	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B4U39_RS30215	COG0298	carbon dioxide binding
B4U39_RS30225	COG0309	Hydrogenase expression formation protein (HypE)
B4U39_RS30240	COG3851	Histidine kinase
B4U39_RS30245	COG2197	response regulator
B4U39_RS30255	COG0515	serine threonine protein kinase
B4U39_RS30320	COG0598	Magnesium transport protein CorA
B4U39_RS30330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U39_RS30335	COG0386	Belongs to the glutathione peroxidase family
B4U39_RS30345	COG3960	tartronate-semialdehyde synthase activity
B4U39_RS30355	COG0753	catalase activity
B4U39_RS30360	COG2084	Dehydrogenase
B4U39_RS30365	COG3622	Belongs to the hyi family
B4U39_RS30385	COG2351	hydroxyisourate hydrolase activity
B4U39_RS30400	COG2233	PERMEase
B4U39_RS30425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B4U39_RS30450	COG2197	response regulator
B4U39_RS30455	COG4585	Histidine kinase
B4U39_RS30470	COG1414	Transcriptional regulator
B4U39_RS30475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U39_RS30480	COG4266	Belongs to the allantoicase family
B4U39_RS30485	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS30500	COG4974	Belongs to the 'phage' integrase family
B4U39_RS30530	COG2188	Transcriptional regulator
B4U39_RS30565	COG0673	inositol 2-dehydrogenase activity
B4U39_RS30580	COG1129	ABC transporter
B4U39_RS30585	COG1940	carbohydrate kinase activity
B4U39_RS30610	COG1126	abc transporter atp-binding protein
B4U39_RS30635	COG0745	RESPONSE REGULATOR receiver
B4U39_RS30640	COG2205	protein histidine kinase activity
B4U39_RS30660	COG0405	Gamma-glutamyltransferase
B4U39_RS30690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U39_RS30695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U39_RS30705	COG0483	inositol monophosphate 1-phosphatase activity
B4U39_RS30715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B4U39_RS30730	COG1448	Aminotransferase
B4U39_RS30750	COG1335	isochorismatase
B4U39_RS30755	COG1929	Belongs to the glycerate kinase type-1 family
B4U39_RS30760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U39_RS30780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U39_RS30795	COG0688	phosphatidylethanolamine metabolic process
B4U39_RS30800	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS30815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS30815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U39_RS30820	COG0604	alcohol dehydrogenase
B4U39_RS30830	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U39_RS30860	COG2362	D-Aminopeptidase
B4U39_RS30865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U39_RS30875	COG1733	regulation of RNA biosynthetic process
B4U39_RS30900	COG0457	Tetratricopeptide repeat
B4U39_RS30915	COG2226	methyltransferase
B4U39_RS30970	COG0531	amino acid
B4U39_RS30990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4U39_RS31000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4U39_RS31040	COG2154	pterin-4-alpha-carbinolamine dehydratase
B4U39_RS31050	COG0656	L-ascorbic acid biosynthetic process
B4U39_RS31090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B4U39_RS31095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U39_RS31115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U39_RS31130	COG2197	response regulator
B4U39_RS31140	COG1288	antiporter activity
B4U39_RS31145	COG0515	serine threonine protein kinase
B4U39_RS31180	COG1486	melibiose metabolic process
B4U39_RS31195	COG1051	belongs to the nudix hydrolase family
B4U39_RS31215	COG1793	dna ligase
B4U39_RS31280	COG0488	(ABC) transporter
B4U39_RS31310	COG1515	deoxyribonuclease V activity
B4U39_RS31315	COG3268	Saccharopine dehydrogenase
B4U39_RS31325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B4U39_RS31330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS31335	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS31340	COG0183	Belongs to the thiolase family
B4U39_RS31345	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U39_RS31345	COG1024	Enoyl-CoA hydratase
B4U39_RS31355	COG0789	Transcriptional regulator
B4U39_RS31360	COG1022	Amp-dependent synthetase and ligase
B4U39_RS31385	COG2183	response to ionizing radiation
B4U39_RS31400	COG0300	oxidoreductase activity
B4U39_RS31405	COG0488	(ABC) transporter
B4U39_RS31410	COG4977	sequence-specific DNA binding
B4U39_RS31420	COG1024	Enoyl-CoA hydratase
B4U39_RS31435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B4U39_RS31440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4U39_RS31455	COG0371	Dehydrogenase
B4U39_RS31475	COG1134	teichoic acid transport
B4U39_RS31480	COG1562	ergosterol biosynthetic process
B4U39_RS31490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4U39_RS31500	COG1657	PFAM Prenyltransferase squalene oxidase
B4U39_RS31530	COG2755	lipolytic protein G-D-S-L family
B4U39_RS31590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U39_RS31600	COG2814	Major facilitator Superfamily
B4U39_RS31625	COG0583	DNA-binding transcription factor activity
B4U39_RS31635	COG0598	Magnesium transport protein CorA
B4U39_RS31645	COG3152	Membrane
B4U39_RS31650	COG2838	Isocitrate dehydrogenase
B4U39_RS31665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4U39_RS31670	COG3119	arylsulfatase activity
B4U39_RS31670	COG3119	arylsulfatase activity
B4U39_RS31690	COG0583	DNA-binding transcription factor activity
B4U39_RS31695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U39_RS31705	COG0247	lactate metabolic process
B4U39_RS31710	COG1139	Iron-sulfur cluster binding protein
B4U39_RS31715	COG1556	Lactate utilization protein
B4U39_RS31720	COG0346	lactoylglutathione lyase activity
B4U39_RS31760	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS31770	COG2327	Polysaccharide pyruvyl transferase
B4U39_RS31800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U39_RS31800	COG0515	serine threonine protein kinase
B4U39_RS31820	COG0831	urea catabolic process
B4U39_RS31820	COG0832	Belongs to the urease beta subunit family
B4U39_RS31825	COG2957	Belongs to the agmatine deiminase family
B4U39_RS31830	COG1132	(ABC) transporter
B4U39_RS31840	COG1231	oxidoreductase activity
B4U39_RS31850	COG1335	isochorismatase
B4U39_RS31860	COG1024	Enoyl-CoA hydratase
B4U39_RS31865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4U39_RS31885	COG3511	phospholipase C
B4U39_RS31895	COG4106	trans-aconitate 2-methyltransferase activity
B4U39_RS31900	COG1819	glycosyl
B4U39_RS31905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4U39_RS31920	COG3321	synthase
B4U39_RS31920	COG0604	alcohol dehydrogenase
B4U39_RS31950	COG3345	alpha-galactosidase
B4U39_RS31965	COG0589	response to stress
B4U39_RS31990	COG1653	transport
B4U39_RS31995	COG1175	transmembrane transport
B4U39_RS32000	COG0395	ABC-type sugar transport system, permease component
B4U39_RS32015	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4U39_RS32015	COG1902	pentaerythritol trinitrate reductase activity
B4U39_RS32125	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS32150	COG0577	efflux transmembrane transporter activity
B4U39_RS32150	COG1136	(ABC) transporter
B4U39_RS32170	COG3835	regulator
B4U39_RS32185	COG1595	DNA-templated transcription, initiation
B4U39_RS32220	COG0668	transmembrane transport
B4U39_RS32240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B4U39_RS32250	COG2267	carboxylic ester hydrolase activity
B4U39_RS32260	COG0165	Argininosuccinate lyase
B4U39_RS32270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U39_RS32285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS32295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS32345	COG0596	Alpha beta hydrolase
B4U39_RS32350	COG1278	Cold shock
B4U39_RS32355	COG0513	Belongs to the DEAD box helicase family
B4U39_RS32410	COG1819	glycosyl
B4U39_RS32440	COG0765	amino acid transport
B4U39_RS32445	COG1126	abc transporter atp-binding protein
B4U39_RS32460	COG1737	Transcriptional regulator
B4U39_RS32470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B4U39_RS32490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4U39_RS32555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4U39_RS32590	COG0726	polysaccharide deacetylase
B4U39_RS32630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U39_RS32640	COG0583	DNA-binding transcription factor activity
B4U39_RS32650	COG1053	succinate dehydrogenase
B4U39_RS32655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4U39_RS32675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS32685	COG3360	Dodecin
B4U39_RS32690	COG2182	Extracellular solute-binding protein
B4U39_RS32705	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B4U39_RS32710	COG0121	glutamine amidotransferase
B4U39_RS32715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4U39_RS32720	COG3572	ergothioneine biosynthetic process
B4U39_RS32735	COG4122	O-methyltransferase activity
B4U39_RS32745	COG0596	Alpha beta hydrolase
B4U39_RS32755	COG1609	Transcriptional regulator
B4U39_RS32760	COG0183	Belongs to the thiolase family
B4U39_RS32770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U39_RS32790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4U39_RS32825	COG2813	Specifically methylates the guanine in position
B4U39_RS32845	COG3835	regulator
B4U39_RS32850	COG0443	Heat shock 70 kDa protein
B4U39_RS32855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4U39_RS32870	COG0542	response to heat
B4U39_RS32895	COG1289	transmembrane transporter activity
B4U39_RS32915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U39_RS32920	COG2226	methyltransferase
B4U39_RS32930	COG3629	intracellular signal transduction
B4U39_RS32930	COG3903	Transcriptional regulator
B4U39_RS32965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U39_RS32975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS33000	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U39_RS33020	COG2197	response regulator
B4U39_RS33025	COG4585	Histidine kinase
B4U39_RS33030	COG1131	(ABC) transporter
B4U39_RS33125	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B4U39_RS33130	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B4U39_RS33135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B4U39_RS33150	COG0531	amino acid
B4U39_RS33155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B4U39_RS33185	COG1725	Transcriptional regulator
B4U39_RS33225	COG1881	PFAM PEBP family protein
B4U39_RS33265	COG1609	Transcriptional regulator
B4U39_RS33270	COG1940	carbohydrate kinase activity
B4U39_RS33275	COG3386	PFAM SMP-30 Gluconolaconase
B4U39_RS33280	COG0800	Aldolase
B4U39_RS33290	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS33295	COG4948	Mandelate Racemase Muconate Lactonizing
B4U39_RS33315	COG1129	ABC transporter
B4U39_RS33320	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4U39_RS33325	COG1349	DNA-binding transcription factor activity
B4U39_RS33350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B4U39_RS33355	COG1349	DNA-binding transcription factor activity
B4U39_RS33360	COG1733	regulation of RNA biosynthetic process
B4U39_RS33395	COG0395	ABC-type sugar transport system, permease component
B4U39_RS33405	COG0667	Aldo Keto reductase
B4U39_RS33410	COG4191	Histidine kinase
B4U39_RS33495	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U39_RS33515	COG4251	negative regulation of phosphorylation
B4U39_RS33520	COG0784	Response regulator, receiver
B4U39_RS33535	COG2197	response regulator
B4U39_RS33545	COG2201	protein-glutamate methylesterase activity
B4U39_RS33550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4U39_RS33560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B4U39_RS33565	COG4521	taurine ABC transporter
B4U39_RS33570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U39_RS33575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS33610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U39_RS33615	COG0596	Alpha beta hydrolase
B4U39_RS33645	COG0598	Magnesium transport protein CorA
B4U39_RS33750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U39_RS33755	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U39_RS33775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4U39_RS33780	COG2271	Major facilitator Superfamily
B4U39_RS33805	COG1764	response to oxidative stress
B4U39_RS33810	COG0300	oxidoreductase activity
B4U39_RS33830	COG4221	oxidoreductase activity
B4U39_RS33845	COG0069	glutamate synthase activity
B4U39_RS33850	COG0028	Belongs to the TPP enzyme family
B4U39_RS33925	COG3387	PFAM Glycoside hydrolase 15-related
B4U39_RS33940	COG1271	oxidase subunit
B4U39_RS33945	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS33965	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B4U39_RS34025	COG0514	ATP-dependent DNA helicase (RecQ)
B4U39_RS34060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U39_RS34065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4U39_RS34090	COG0671	phosphoesterase, PA-phosphatase related
B4U39_RS34100	COG0783	Belongs to the Dps family
B4U39_RS34105	COG3848	Pyruvate phosphate dikinase
B4U39_RS34105	COG0574	Belongs to the PEP-utilizing enzyme family
B4U39_RS34125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B4U39_RS34200	COG4716	Myosin-crossreactive antigen
B4U39_RS34220	COG0596	Alpha beta hydrolase
B4U39_RS34255	COG2326	polyphosphate kinase activity
B4U39_RS34275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B4U39_RS34305	COG1428	Deoxynucleoside kinase
B4U39_RS34315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4U39_RS34320	COG0596	Alpha beta hydrolase
B4U39_RS34325	COG1309	transcriptional regulator
B4U39_RS34345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4U39_RS34390	COG0148	phosphopyruvate hydratase activity
B4U39_RS34400	COG1902	pentaerythritol trinitrate reductase activity
B4U39_RS34410	COG4941	Belongs to the sigma-70 factor family
B4U39_RS34415	COG3795	YCII-related domain
B4U39_RS34435	COG1132	(ABC) transporter
B4U39_RS34440	COG1132	(ABC) transporter
B4U39_RS34450	COG0515	serine threonine protein kinase
B4U39_RS34490	COG0142	geranyltranstransferase activity
B4U39_RS34495	COG4585	Histidine kinase
B4U39_RS34530	COG0492	ferredoxin-NADP+ reductase activity
B4U39_RS34535	COG4591	ABC-type transport system involved in lipoprotein release permease component
B4U39_RS34535	COG1136	(ABC) transporter
B4U39_RS34550	COG1136	(ABC) transporter
B4U39_RS34560	COG1609	Transcriptional regulator
B4U39_RS34610	COG2226	methyltransferase
B4U39_RS34645	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B4U39_RS34690	COG4221	oxidoreductase activity
B4U39_RS34715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U39_RS34730	COG0277	FAD linked oxidase domain protein
B4U39_RS34760	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4U39_RS34765	COG1129	ABC transporter
B4U39_RS34770	COG3284	Transcriptional regulator
B4U39_RS34815	COG2409	Drug exporters of the RND superfamily
B4U39_RS34820	COG5002	protein histidine kinase activity
B4U39_RS34825	COG0745	RESPONSE REGULATOR receiver
B4U39_RS34830	COG2909	trisaccharide binding
B4U39_RS34865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U39_RS34965	COG0702	epimerase
B4U39_RS34995	COG0789	Transcriptional regulator
B4U39_RS35075	COG1733	regulation of RNA biosynthetic process
B4U39_RS35080	COG0702	epimerase
B4U39_RS35110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U39_RS35125	COG2197	response regulator
B4U39_RS35130	COG0393	Putative heavy-metal-binding
B4U39_RS35135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U39_RS35165	COG2814	Major facilitator Superfamily
B4U39_RS35175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B4U39_RS35185	COG2356	endonuclease I
B4U39_RS35190	COG0693	protein deglycase activity
B4U39_RS35195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U39_RS35225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B4U39_RS35235	COG0515	serine threonine protein kinase
B4U39_RS35235	COG2815	serine threonine protein kinase
B4U39_RS35250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4U39_RS35285	COG1024	Enoyl-CoA hydratase
B4U39_RS35300	COG2378	regulation of single-species biofilm formation
B4U39_RS35305	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS35320	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS35325	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS35340	COG2304	oxidoreductase activity
B4U39_RS35360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B4U39_RS35390	COG1301	dicarboxylic acid transport
B4U39_RS35395	COG3290	protein histidine kinase activity
B4U39_RS35400	COG4565	transcriptional regulatory protein
B4U39_RS35420	COG0789	Transcriptional regulator
B4U39_RS35435	COG0076	glutamate decarboxylase activity
B4U39_RS35440	COG4106	trans-aconitate 2-methyltransferase activity
B4U39_RS35450	COG1414	Transcriptional regulator
B4U39_RS35455	COG0800	Aldolase
B4U39_RS35500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U39_RS35505	COG1120	ATPase activity
B4U39_RS35550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B4U39_RS35560	COG0667	Aldo Keto reductase
B4U39_RS35570	COG1131	(ABC) transporter
B4U39_RS35575	COG1793	dna ligase
B4U39_RS35580	COG2801	Transposase and inactivated derivatives
B4U39_RS35580	COG3415	Transposase
B4U39_RS35590	COG0598	Magnesium transport protein CorA
B4U39_RS35625	COG0477	Major facilitator Superfamily
B4U39_RS35630	COG1404	Belongs to the peptidase S8 family
B4U39_RS35630	COG4412	M6 family metalloprotease domain protein
B4U39_RS35630	COG1404	Belongs to the peptidase S8 family
B4U39_RS35630	COG4412	M6 family metalloprotease domain protein
B4U39_RS35640	COG2124	cytochrome p450
B4U39_RS35655	COG3265	gluconokinase activity
B4U39_RS35670	COG1595	DNA-templated transcription, initiation
B4U39_RS35680	COG0656	L-ascorbic acid biosynthetic process
B4U39_RS35720	COG1796	DNA polymerase
B4U39_RS35720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U39_RS35725	COG1028	Short-chain dehydrogenase reductase Sdr
B4U39_RS35855	COG0071	Belongs to the small heat shock protein (HSP20) family
B4U39_RS35865	COG2072	flavoprotein involved in K transport
B4U39_RS35870	COG0640	Transcriptional regulator
B4U39_RS35875	COG1247	-acetyltransferase
B4U39_RS35900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U39_RS36035	COG2124	cytochrome p450
B4U39_RS36095	COG1132	(ABC) transporter
B4U39_RS36125	COG2197	response regulator
B4U39_RS36130	COG4585	Histidine kinase
B4U39_RS36155	COG0277	FAD linked oxidase domain protein
B4U39_RS36160	COG2226	methyltransferase
B4U39_RS36175	COG2801	Transposase and inactivated derivatives
B4U39_RS36175	COG3415	Transposase
B4U39_RS36190	COG1846	Transcriptional regulator
B4U39_RS36195	COG2188	Transcriptional regulator
B4U39_RS36200	COG0517	IMP dehydrogenase activity
B4U39_RS36200	COG4175	Glycine betaine
B4U39_RS36205	COG4176	ABC-type proline glycine betaine transport system permease component
B4U39_RS36210	COG2409	Drug exporters of the RND superfamily
B4U39_RS36225	COG2197	response regulator
B4U39_RS36235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U39_RS36250	COG0583	DNA-binding transcription factor activity
B4U39_RS36255	COG0477	Major facilitator Superfamily
B4U39_RS36320	COG0666	response to abiotic stimulus
B4U39_RS36350	COG0714	Associated with various cellular activities
B4U39_RS36390	COG2272	Belongs to the type-B carboxylesterase lipase family
B4U39_RS36420	COG1796	DNA polymerase
B4U39_RS36420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U39_RS36425	COG1846	Transcriptional regulator
B4U39_RS36450	COG2304	oxidoreductase activity
B4U39_RS36460	COG1686	Belongs to the peptidase S11 family
B4U39_RS36510	COG0681	Belongs to the peptidase S26 family
B4U39_RS36535	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS36565	COG0583	DNA-binding transcription factor activity
B4U39_RS36575	COG2201	protein-glutamate methylesterase activity
B4U39_RS36625	COG1595	DNA-templated transcription, initiation
B4U39_RS36635	COG1278	Cold shock
B4U39_RS36650	COG2197	response regulator
B4U39_RS36665	COG4585	Histidine kinase
B4U39_RS36670	COG0328	RNA-DNA hybrid ribonuclease activity
B4U39_RS36695	COG0009	L-threonylcarbamoyladenylate synthase
B4U39_RS36700	COG4585	Histidine kinase
B4U39_RS36705	COG2197	response regulator
B4U39_RS36710	COG0671	phosphoesterase, PA-phosphatase related
B4U39_RS36735	COG1228	amidohydrolase
B4U39_RS36785	COG2267	carboxylic ester hydrolase activity
B4U39_RS36845	COG2205	protein histidine kinase activity
B4U39_RS36850	COG0745	RESPONSE REGULATOR receiver
B4U39_RS36855	COG0477	Major facilitator Superfamily
B4U39_RS36860	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B4U39_RS36880	COG0559	Belongs to the binding-protein-dependent transport system permease family
B4U39_RS36900	COG0432	Pfam Uncharacterised protein family UPF0047
B4U39_RS36915	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B4U39_RS36935	COG0308	aminopeptidase N
B4U39_RS36955	COG3290	protein histidine kinase activity
B4U39_RS37010	COG1316	TRANSCRIPTIONal
B4U39_RS37035	COG1309	transcriptional regulator
B4U39_RS37045	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS37050	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS37055	COG0045	succinate-CoA ligase (ADP-forming) activity
B4U39_RS37055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U39_RS37055	COG1042	CoA-binding domain protein
B4U39_RS37065	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B4U39_RS37085	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4U39_RS37090	COG1177	transmembrane transport
B4U39_RS37095	COG3842	ATPase activity
B4U39_RS37105	COG1012	belongs to the aldehyde dehydrogenase family
B4U39_RS37115	COG0667	Aldo Keto reductase
B4U39_RS37120	COG1309	transcriptional regulator
B4U39_RS37145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4U39_RS37155	COG0500	methyltransferase
B4U39_RS37280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U39_RS37285	COG0745	RESPONSE REGULATOR receiver
B4U39_RS37290	COG2205	protein histidine kinase activity
B4U39_RS37295	COG1278	Cold shock
B4U39_RS37300	COG0513	Belongs to the DEAD box helicase family
B4U39_RS37360	COG0583	DNA-binding transcription factor activity
B4U39_RS37390	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS37405	COG0318	PFAM AMP-dependent synthetase and ligase
B4U39_RS37410	COG0438	transferase activity, transferring glycosyl groups
B4U39_RS37420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B4U39_RS37440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U39_RS37590	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS37600	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B4U39_RS37615	COG0488	(ABC) transporter
B4U39_RS37645	COG2801	Transposase and inactivated derivatives
B4U39_RS37650	COG2801	Transposase and inactivated derivatives
B4U39_RS37695	COG4977	sequence-specific DNA binding
B4U39_RS37705	COG2267	carboxylic ester hydrolase activity
B4U39_RS37720	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS37790	COG1192	Involved in chromosome partitioning
B4U39_RS37830	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS37840	COG3328	transposase activity
B4U39_RS37855	COG1192	Involved in chromosome partitioning
B4U39_RS37900	COG0702	epimerase
B4U39_RS37955	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS38130	COG2801	Transposase and inactivated derivatives
B4U39_RS38140	COG0697	spore germination
B4U39_RS38175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U39_RS38190	COG1652	LysM domain
B4U39_RS38340	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS38490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U39_RS38495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U39_RS38505	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS38580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B4U39_RS38630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U39_RS38640	COG1595	DNA-templated transcription, initiation
B4U39_RS38685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U39_RS38700	COG2801	Transposase and inactivated derivatives
B4U39_RS38765	COG3293	Transposase
B4U39_RS38775	COG2814	Major facilitator Superfamily
B4U39_RS38880	COG4948	Mandelate Racemase Muconate Lactonizing
B4U39_RS38940	COG1333	cytochrome c biogenesis protein
B4U39_RS38945	COG0596	Alpha beta hydrolase
B4U39_RS38955	COG1902	pentaerythritol trinitrate reductase activity
B4U39_RS38965	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS38975	COG1104	cysteine desulfurase activity
B4U39_RS38980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U39_RS39010	COG0697	spore germination
B4U39_RS39030	COG1960	acyl-CoA dehydrogenase activity
B4U39_RS39105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U39_RS39110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U39_RS39115	COG0277	FAD linked oxidase domain protein
B4U39_RS39145	COG0789	Transcriptional regulator
B4U39_RS39250	COG0351	phosphomethylpyrimidine kinase
B4U39_RS39350	COG2172	sigma factor antagonist activity
B4U39_RS39370	COG0720	synthase
B4U39_RS39375	COG0602	queuosine metabolic process
B4U39_RS39380	COG0302	gtp cyclohydrolase
B4U39_RS39395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4U39_RS39440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U39_RS39445	COG3708	Transcriptional regulator
B4U39_RS39445	COG2207	Transcriptional regulator
B4U39_RS39510	COG0728	peptidoglycan biosynthetic process
B4U39_RS39515	COG1376	ErfK ybiS ycfS ynhG family protein
B4U39_RS39630	COG1192	Involved in chromosome partitioning
B4U39_RS39635	COG1475	DNA binding
B4U39_RS39670	COG3328	transposase activity
B4U39_RS39735	COG1484	DNA-dependent DNA replication
B4U39_RS39920	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS40020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B4U39_RS40130	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4U39_RS40135	COG0674	pyruvate-flavodoxin oxidoreductase activity
B4U39_RS40135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B4U39_RS40145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4U39_RS40230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U39_RS40295	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B4U39_RS40460	COG0629	single-stranded DNA binding
B4U39_RS40485	COG1278	Cold shock
B4U39_RS40560	COG1051	belongs to the nudix hydrolase family
B4U39_RS40605	COG3328	transposase activity
B4U39_RS40610	COG2801	Transposase and inactivated derivatives
B4U39_RS40630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U39_RS40645	COG0789	Transcriptional regulator
B4U39_RS40655	COG1404	Belongs to the peptidase S8 family
B4U39_RS40750	COG3293	Transposase
B4U39_RS40785	COG3293	Transposase
B4U39_RS40800	COG2124	cytochrome p450
B4U39_RS40825	COG1278	Cold shock
B4U39_RS40865	COG2356	endonuclease I
B4U39_RS40905	COG3547	Transposase (IS116 IS110 IS902 family)
B4U39_RS40960	COG2801	Transposase and inactivated derivatives