locus-tag	class	description
DC008_RS00035	COG2124	cytochrome p450
DC008_RS00090	COG1595	DNA-templated transcription, initiation
DC008_RS00095	COG0784	Response regulator, receiver
DC008_RS00105	COG4251	negative regulation of phosphorylation
DC008_RS00135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DC008_RS00160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DC008_RS00250	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DC008_RS00255	COG1691	(AIR) carboxylase
DC008_RS00260	COG3875	lactate racemase activity
DC008_RS00265	COG3618	amidohydrolase
DC008_RS00275	COG0179	Fumarylacetoacetate (FAA) hydrolase
DC008_RS00280	COG2186	Transcriptional regulator
DC008_RS00285	COG4948	Mandelate Racemase Muconate Lactonizing
DC008_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS00300	COG1129	ABC transporter
DC008_RS00315	COG1309	transcriptional regulator
DC008_RS00365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DC008_RS00370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC008_RS00375	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DC008_RS00385	COG0601	transmembrane transport
DC008_RS00390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC008_RS00395	COG0444	Belongs to the ABC transporter superfamily
DC008_RS00400	COG1124	(ABC) transporter
DC008_RS00415	COG0517	IMP dehydrogenase activity
DC008_RS00420	COG0045	succinate-CoA ligase (ADP-forming) activity
DC008_RS00420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC008_RS00420	COG1042	CoA-binding domain protein
DC008_RS00435	COG0589	response to stress
DC008_RS00460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DC008_RS00470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DC008_RS00485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DC008_RS00485	COG0574	Belongs to the PEP-utilizing enzyme family
DC008_RS00500	COG1454	alcohol dehydrogenase
DC008_RS00500	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS00505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DC008_RS00505	COG4651	solute:proton antiporter activity
DC008_RS00510	COG0490	domain, Protein
DC008_RS00510	COG2985	domain, Protein
DC008_RS00530	COG4585	Histidine kinase
DC008_RS00535	COG2197	response regulator
DC008_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS00580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DC008_RS00580	COG1017	nitric oxide dioxygenase activity
DC008_RS00600	COG0596	Alpha beta hydrolase
DC008_RS00610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DC008_RS00655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DC008_RS00665	COG1725	Transcriptional regulator
DC008_RS00685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DC008_RS00715	COG1501	Belongs to the glycosyl hydrolase 31 family
DC008_RS00720	COG0395	ABC-type sugar transport system, permease component
DC008_RS00750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DC008_RS00755	COG4948	Mandelate Racemase Muconate Lactonizing
DC008_RS00770	COG4166	transmembrane transport
DC008_RS00775	COG0601	transmembrane transport
DC008_RS00780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC008_RS00790	COG1733	regulation of RNA biosynthetic process
DC008_RS00810	COG0384	phenazine biosynthesis protein PhzF
DC008_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS00850	COG1024	Enoyl-CoA hydratase
DC008_RS00870	COG0574	Belongs to the PEP-utilizing enzyme family
DC008_RS00870	COG3848	Pyruvate phosphate dikinase
DC008_RS00890	COG1309	transcriptional regulator
DC008_RS00900	COG0655	NAD(P)H dehydrogenase (quinone) activity
DC008_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS00915	COG1846	Transcriptional regulator
DC008_RS00930	COG1404	Belongs to the peptidase S8 family
DC008_RS00945	COG1404	Belongs to the peptidase S8 family
DC008_RS00950	COG2814	Major facilitator Superfamily
DC008_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS00995	COG1252	NADH dehydrogenase
DC008_RS01010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DC008_RS01030	COG0583	DNA-binding transcription factor activity
DC008_RS01035	COG1846	Transcriptional regulator
DC008_RS01085	COG0655	NAD(P)H dehydrogenase (quinone) activity
DC008_RS01105	COG2318	DinB family
DC008_RS01130	COG1082	Xylose isomerase domain protein TIM barrel
DC008_RS01140	COG2186	Transcriptional regulator
DC008_RS01145	COG0129	dihydroxy-acid dehydratase activity
DC008_RS01160	COG4221	oxidoreductase activity
DC008_RS01165	COG1472	Belongs to the glycosyl hydrolase 3 family
DC008_RS01175	COG1175	transmembrane transport
DC008_RS01180	COG1653	transport
DC008_RS01200	COG0726	polysaccharide deacetylase
DC008_RS01220	COG2208	phosphoserine phosphatase activity
DC008_RS01220	COG2770	Histidine kinase
DC008_RS01240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DC008_RS01245	COG0604	alcohol dehydrogenase
DC008_RS01250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DC008_RS01285	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS01290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DC008_RS01320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC008_RS01330	COG1309	transcriptional regulator
DC008_RS01340	COG0531	amino acid
DC008_RS01345	COG0702	epimerase
DC008_RS01355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DC008_RS01355	COG1263	PTS System
DC008_RS01360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DC008_RS01375	COG1595	DNA-templated transcription, initiation
DC008_RS01385	COG1737	Transcriptional regulator
DC008_RS01395	COG1686	Belongs to the peptidase S11 family
DC008_RS01400	COG2205	protein histidine kinase activity
DC008_RS01405	COG0745	RESPONSE REGULATOR receiver
DC008_RS01445	COG1902	pentaerythritol trinitrate reductase activity
DC008_RS01480	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DC008_RS01490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS01530	COG1271	oxidase subunit
DC008_RS01540	COG0589	response to stress
DC008_RS01555	COG0789	Transcriptional regulator
DC008_RS01565	COG0095	Lipoate-protein ligase
DC008_RS01570	COG0477	Major facilitator Superfamily
DC008_RS01580	COG3708	Transcriptional regulator
DC008_RS01580	COG2207	Transcriptional regulator
DC008_RS01620	COG3537	Alpha-1,2-mannosidase
DC008_RS01630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DC008_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS01700	COG2226	methyltransferase
DC008_RS01715	COG2226	methyltransferase
DC008_RS01745	COG2045	Belongs to the ComB family
DC008_RS01785	COG1017	nitric oxide dioxygenase activity
DC008_RS01785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DC008_RS01795	COG1073	alpha beta
DC008_RS01805	COG0583	DNA-binding transcription factor activity
DC008_RS01825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DC008_RS01845	COG0477	Major facilitator Superfamily
DC008_RS01850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DC008_RS01855	COG0254	rRNA binding
DC008_RS01860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DC008_RS01890	COG1295	ribonuclease BN
DC008_RS01930	COG1172	Belongs to the binding-protein-dependent transport system permease family
DC008_RS01935	COG1172	Belongs to the binding-protein-dependent transport system permease family
DC008_RS01940	COG1129	ABC transporter
DC008_RS01950	COG1609	Transcriptional regulator
DC008_RS01960	COG3250	beta-galactosidase activity
DC008_RS01975	COG1609	Transcriptional regulator
DC008_RS01985	COG2814	Major facilitator Superfamily
DC008_RS02020	COG2814	Major facilitator Superfamily
DC008_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS02045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DC008_RS02050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DC008_RS02060	COG0438	transferase activity, transferring glycosyl groups
DC008_RS02080	COG2770	Histidine kinase
DC008_RS02080	COG2208	phosphoserine phosphatase activity
DC008_RS02085	COG0596	Alpha beta hydrolase
DC008_RS02105	COG2188	Transcriptional regulator
DC008_RS02155	COG0477	Major facilitator Superfamily
DC008_RS02165	COG0596	Alpha beta hydrolase
DC008_RS02170	COG0346	lactoylglutathione lyase activity
DC008_RS02175	COG0640	Transcriptional regulator
DC008_RS02185	COG2084	Dehydrogenase
DC008_RS02205	COG3386	PFAM SMP-30 Gluconolaconase
DC008_RS02210	COG0800	Aldolase
DC008_RS02220	COG4948	Mandelate Racemase Muconate Lactonizing
DC008_RS02225	COG2186	Transcriptional regulator
DC008_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS02240	COG0395	ABC-type sugar transport system, permease component
DC008_RS02240	COG0395	ABC-type sugar transport system, permease component
DC008_RS02245	COG1175	transmembrane transport
DC008_RS02255	COG3345	alpha-galactosidase
DC008_RS02265	COG0667	Aldo Keto reductase
DC008_RS02285	COG0583	DNA-binding transcription factor activity
DC008_RS02300	COG3739	integral membrane protein
DC008_RS02315	COG1132	(ABC) transporter
DC008_RS02335	COG3290	protein histidine kinase activity
DC008_RS02405	COG0438	transferase activity, transferring glycosyl groups
DC008_RS02410	COG0667	Aldo Keto reductase
DC008_RS02415	COG0673	inositol 2-dehydrogenase activity
DC008_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS02510	COG0740	serine-type endopeptidase activity
DC008_RS02515	COG0740	serine-type endopeptidase activity
DC008_RS02550	COG1131	(ABC) transporter
DC008_RS02550	COG1716	ATPase activity
DC008_RS02550	COG0842	Transport permease protein
DC008_RS02565	COG0667	Aldo Keto reductase
DC008_RS02570	COG0583	DNA-binding transcription factor activity
DC008_RS02580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC008_RS02585	COG0346	lactoylglutathione lyase activity
DC008_RS02590	COG0667	Aldo Keto reductase
DC008_RS02600	COG4941	Belongs to the sigma-70 factor family
DC008_RS02615	COG0702	epimerase
DC008_RS02645	COG5001	Diguanylate cyclase
DC008_RS02730	COG1024	Enoyl-CoA hydratase
DC008_RS02755	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS02760	COG2366	antibiotic biosynthetic process
DC008_RS02770	COG2070	2-Nitropropane dioxygenase
DC008_RS02775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC008_RS02785	COG0515	serine threonine protein kinase
DC008_RS02795	COG1960	acyl-CoA dehydrogenase activity
DC008_RS02815	COG2326	polyphosphate kinase activity
DC008_RS02840	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS02890	COG2376	Dihydroxyacetone kinase
DC008_RS02895	COG1461	Dihydroxyacetone kinase
DC008_RS02900	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DC008_RS02925	COG0446	pyridine nucleotide-disulphide oxidoreductase
DC008_RS02925	COG1902	pentaerythritol trinitrate reductase activity
DC008_RS02945	COG2890	protein-(glutamine-N5) methyltransferase activity
DC008_RS02950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DC008_RS02965	COG3458	cephalosporin-C deacetylase activity
DC008_RS02970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC008_RS02975	COG2188	Transcriptional regulator
DC008_RS02985	COG2226	methyltransferase
DC008_RS03000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DC008_RS03005	COG1686	Belongs to the peptidase S11 family
DC008_RS03010	COG2066	Belongs to the glutaminase family
DC008_RS03020	COG2186	Transcriptional regulator
DC008_RS03025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DC008_RS03030	COG1993	acr, cog1993
DC008_RS03035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DC008_RS03045	COG0640	Transcriptional regulator
DC008_RS03070	COG3291	Pkd domain containing protein
DC008_RS03095	COG1024	Enoyl-CoA hydratase
DC008_RS03095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DC008_RS03100	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DC008_RS03105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DC008_RS03110	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DC008_RS03115	COG0298	carbon dioxide binding
DC008_RS03130	COG0375	protein maturation
DC008_RS03150	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DC008_RS03170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DC008_RS03185	COG2340	Cysteine-rich secretory protein family
DC008_RS03195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DC008_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS03215	COG1051	belongs to the nudix hydrolase family
DC008_RS03240	COG1215	transferase activity, transferring glycosyl groups
DC008_RS03275	COG1349	DNA-binding transcription factor activity
DC008_RS03305	COG0698	ribose 5-phosphate isomerase
DC008_RS03310	COG1940	carbohydrate kinase activity
DC008_RS03320	COG2813	Specifically methylates the guanine in position
DC008_RS03330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DC008_RS03335	COG1349	DNA-binding transcription factor activity
DC008_RS03340	COG3387	PFAM Glycoside hydrolase 15-related
DC008_RS03385	COG0326	Molecular chaperone. Has ATPase activity
DC008_RS03400	COG3594	Acyltransferase
DC008_RS03445	COG3251	PFAM MbtH domain protein
DC008_RS03450	COG2382	esterase
DC008_RS03455	COG1132	(ABC) transporter
DC008_RS03465	COG1132	(ABC) transporter
DC008_RS03470	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DC008_RS03475	COG1120	ATPase activity
DC008_RS03480	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC008_RS03485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC008_RS03490	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DC008_RS03500	COG2223	nitrite transmembrane transporter activity
DC008_RS03510	COG2197	response regulator
DC008_RS03515	COG4585	Histidine kinase
DC008_RS03540	COG1660	Displays ATPase and GTPase activities
DC008_RS03550	COG1090	epimerase
DC008_RS03570	COG0515	serine threonine protein kinase
DC008_RS03570	COG2815	serine threonine protein kinase
DC008_RS03580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DC008_RS03605	COG0204	Acyl-transferase
DC008_RS03630	COG0584	glycerophosphoryl diester phosphodiesterase
DC008_RS03660	COG0671	phosphoesterase, PA-phosphatase related
DC008_RS03670	COG1309	transcriptional regulator
DC008_RS03695	COG0640	Transcriptional regulator
DC008_RS03700	COG1902	pentaerythritol trinitrate reductase activity
DC008_RS03710	COG1960	acyl-CoA dehydrogenase activity
DC008_RS03725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DC008_RS03770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DC008_RS03775	COG2151	metal-sulfur cluster biosynthetic enzyme
DC008_RS03780	COG3396	Phenylacetate-CoA oxygenase
DC008_RS03785	COG3460	Phenylacetate-CoA oxygenase
DC008_RS03790	COG3396	Phenylacetate-CoA oxygenase
DC008_RS03845	COG0432	Pfam Uncharacterised protein family UPF0047
DC008_RS03850	COG2072	flavoprotein involved in K transport
DC008_RS03855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DC008_RS03860	COG1132	(ABC) transporter
DC008_RS03875	COG1132	(ABC) transporter
DC008_RS03880	COG1132	(ABC) transporter
DC008_RS03890	COG0254	rRNA binding
DC008_RS03905	COG1946	Acyl-CoA thioesterase
DC008_RS03915	COG2018	Roadblock/LC7 domain
DC008_RS03975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DC008_RS04015	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS04030	COG0659	secondary active sulfate transmembrane transporter activity
DC008_RS04040	COG1408	metallophosphoesterase
DC008_RS04050	COG0745	RESPONSE REGULATOR receiver
DC008_RS04100	COG4176	ABC-type proline glycine betaine transport system permease component
DC008_RS04105	COG0517	IMP dehydrogenase activity
DC008_RS04105	COG4175	Glycine betaine
DC008_RS04125	COG4638	Rieske (2fe-2S)
DC008_RS04130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC008_RS04135	COG2146	nitrite reductase [NAD(P)H] activity
DC008_RS04155	COG4213	ABC transporter substrate-binding protein
DC008_RS04165	COG4213	ABC transporter substrate-binding protein
DC008_RS04175	COG4214	carbohydrate transport
DC008_RS04180	COG0586	Pfam SNARE associated Golgi protein
DC008_RS04205	COG1960	acyl-CoA dehydrogenase activity
DC008_RS04210	COG1960	acyl-CoA dehydrogenase activity
DC008_RS04225	COG3118	belongs to the thioredoxin family
DC008_RS04225	COG0492	ferredoxin-NADP+ reductase activity
DC008_RS04230	COG1793	dna ligase
DC008_RS04250	COG1960	acyl-CoA dehydrogenase activity
DC008_RS04260	COG0242	peptide deformylase activity
DC008_RS04270	COG3442	glutamine amidotransferase
DC008_RS04275	COG0205	6-phosphofructokinase activity
DC008_RS04290	COG3275	phosphorelay sensor kinase activity
DC008_RS04295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DC008_RS04305	COG3279	Response regulator of the LytR AlgR family
DC008_RS04310	COG1522	sequence-specific DNA binding
DC008_RS04315	COG1834	amidinotransferase
DC008_RS04320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DC008_RS04340	COG0829	nickel cation binding
DC008_RS04345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DC008_RS04355	COG0804	urea catabolic process
DC008_RS04360	COG0832	Belongs to the urease beta subunit family
DC008_RS04365	COG0831	urea catabolic process
DC008_RS04370	COG1309	transcriptional regulator
DC008_RS04380	COG0791	NLP P60 protein
DC008_RS04405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DC008_RS04410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DC008_RS04415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DC008_RS04420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC008_RS04435	COG1136	(ABC) transporter
DC008_RS04435	COG0577	efflux transmembrane transporter activity
DC008_RS04440	COG0577	efflux transmembrane transporter activity
DC008_RS04440	COG1136	(ABC) transporter
DC008_RS04445	COG0456	acetyltransferase
DC008_RS04470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DC008_RS04495	COG4585	Histidine kinase
DC008_RS04500	COG2197	response regulator
DC008_RS04505	COG1940	carbohydrate kinase activity
DC008_RS04510	COG2188	Transcriptional regulator
DC008_RS04515	COG1595	DNA-templated transcription, initiation
DC008_RS04520	COG0596	Alpha beta hydrolase
DC008_RS04530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DC008_RS04555	COG0626	cystathionine gamma-synthase activity
DC008_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS04585	COG1522	sequence-specific DNA binding
DC008_RS04590	COG0419	ATPase involved in DNA repair
DC008_RS04595	COG0420	3'-5' exonuclease activity
DC008_RS04605	COG1739	Uncharacterized protein family UPF0029
DC008_RS04620	COG1832	CoA-binding protein
DC008_RS04630	COG0640	Transcriptional regulator
DC008_RS04700	COG0183	Belongs to the thiolase family
DC008_RS04710	COG1968	undecaprenyl-diphosphatase activity
DC008_RS04735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DC008_RS04755	COG2318	DinB family
DC008_RS04770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DC008_RS04775	COG0747	negative chemotaxis
DC008_RS04820	COG0697	spore germination
DC008_RS04890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DC008_RS04895	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DC008_RS04900	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DC008_RS04910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DC008_RS04910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DC008_RS04940	COG1716	ATPase activity
DC008_RS04960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DC008_RS04995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DC008_RS05005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DC008_RS05025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC008_RS05030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DC008_RS05035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DC008_RS05055	COG2018	Roadblock/LC7 domain
DC008_RS05090	COG2814	Major facilitator Superfamily
DC008_RS05095	COG4336	lyase activity
DC008_RS05100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DC008_RS05105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DC008_RS05110	COG1984	allophanate hydrolase subunit 2
DC008_RS05135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DC008_RS05140	COG2364	Membrane
DC008_RS05150	COG2270	Major facilitator Superfamily
DC008_RS05160	COG3030	protein affecting phage T7 exclusion by the F plasmid
DC008_RS05165	COG1216	Glycosyl transferase, family 2
DC008_RS05190	COG1960	acyl-CoA dehydrogenase activity
DC008_RS05250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DC008_RS05255	COG0140	phosphoribosyl-ATP diphosphatase activity
DC008_RS05260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DC008_RS05265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DC008_RS05265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DC008_RS05270	COG3201	nicotinamide mononucleotide transporter
DC008_RS05285	COG1846	Transcriptional regulator
DC008_RS05285	COG1940	carbohydrate kinase activity
DC008_RS05290	COG2223	nitrite transmembrane transporter activity
DC008_RS05300	COG2233	PERMEase
DC008_RS05325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DC008_RS05340	COG0531	amino acid
DC008_RS05355	COG2390	Transcriptional regulator
DC008_RS05360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DC008_RS05365	COG2409	Drug exporters of the RND superfamily
DC008_RS05375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DC008_RS05390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DC008_RS05400	COG1758	RNA polymerase activity
DC008_RS05405	COG0194	GDP metabolic process
DC008_RS05415	COG0284	orotidine-5'-phosphate decarboxylase activity
DC008_RS05420	COG0167	dihydroorotate dehydrogenase activity
DC008_RS05425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DC008_RS05430	COG0505	Belongs to the CarA family
DC008_RS05440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DC008_RS05445	COG0540	Belongs to the ATCase OTCase family
DC008_RS05450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DC008_RS05460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DC008_RS05465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DC008_RS05470	COG0006	proline dipeptidase activity
DC008_RS05480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DC008_RS05485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DC008_RS05490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DC008_RS05500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DC008_RS05510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DC008_RS05515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DC008_RS05530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DC008_RS05545	COG0124	histidyl-tRNA synthetase
DC008_RS05555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DC008_RS05560	COG1196	nuclear chromosome segregation
DC008_RS05565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DC008_RS05570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DC008_RS05575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DC008_RS05580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DC008_RS05590	COG2255	four-way junction helicase activity
DC008_RS05595	COG0632	four-way junction helicase activity
DC008_RS05600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DC008_RS05605	COG0217	transcriptional regulatory protein
DC008_RS05610	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DC008_RS05615	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DC008_RS05625	COG0438	transferase activity, transferring glycosyl groups
DC008_RS05630	COG1560	Kdo2-lipid A biosynthetic process
DC008_RS05635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DC008_RS05655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DC008_RS05660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DC008_RS05675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DC008_RS05725	COG0456	acetyltransferase
DC008_RS05735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DC008_RS05790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DC008_RS05790	COG1648	precorrin-2 dehydrogenase activity
DC008_RS05795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DC008_RS05810	COG1464	Belongs to the NlpA lipoprotein family
DC008_RS05815	COG2011	ABC-type metal ion transport system permease component
DC008_RS05820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DC008_RS05825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DC008_RS05855	COG0204	Acyl-transferase
DC008_RS05855	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS05860	COG0477	Major facilitator Superfamily
DC008_RS05875	COG0165	Argininosuccinate lyase
DC008_RS05905	COG1438	arginine binding
DC008_RS05910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DC008_RS05915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DC008_RS05920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DC008_RS05925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DC008_RS05970	COG0697	spore germination
DC008_RS05980	COG1649	PFAM Uncharacterised BCR, COG1649
DC008_RS06010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DC008_RS06010	COG0072	phenylalanine-tRNA ligase activity
DC008_RS06015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DC008_RS06020	COG5002	protein histidine kinase activity
DC008_RS06025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DC008_RS06030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DC008_RS06035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DC008_RS06040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DC008_RS06085	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS06090	COG0174	glutamine synthetase
DC008_RS06095	COG2186	Transcriptional regulator
DC008_RS06100	COG0531	amino acid
DC008_RS06130	COG4176	ABC-type proline glycine betaine transport system permease component
DC008_RS06135	COG0517	IMP dehydrogenase activity
DC008_RS06135	COG4175	Glycine betaine
DC008_RS06140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DC008_RS06150	COG2124	cytochrome p450
DC008_RS06185	COG3973	AAA domain
DC008_RS06200	COG0805	protein transport
DC008_RS06205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DC008_RS06240	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DC008_RS06250	COG1609	Transcriptional regulator
DC008_RS06255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DC008_RS06260	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DC008_RS06275	COG4122	O-methyltransferase activity
DC008_RS06280	COG1222	aaa ATPase
DC008_RS06305	COG1994	Peptidase M50
DC008_RS06305	COG0517	IMP dehydrogenase activity
DC008_RS06315	COG2197	response regulator
DC008_RS06320	COG4166	transmembrane transport
DC008_RS06325	COG0747	negative chemotaxis
DC008_RS06335	COG1410	methionine synthase
DC008_RS06335	COG0646	methionine synthase
DC008_RS06340	COG1414	Transcriptional regulator
DC008_RS06345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DC008_RS06350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DC008_RS06355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DC008_RS06360	COG2186	Transcriptional regulator
DC008_RS06370	COG0215	cysteine-tRNA ligase activity
DC008_RS06385	COG0588	phosphoglycerate mutase activity
DC008_RS06390	COG0598	Magnesium transport protein CorA
DC008_RS06400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS06405	COG0667	Aldo Keto reductase
DC008_RS06440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC008_RS06460	COG3012	SEC-C Motif Domain Protein
DC008_RS06465	COG2186	Transcriptional regulator
DC008_RS06470	COG3265	gluconokinase activity
DC008_RS06510	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DC008_RS06515	COG2149	membrane
DC008_RS06540	COG1960	acyl-CoA dehydrogenase activity
DC008_RS06550	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS06560	COG3876	Protein conserved in bacteria
DC008_RS06585	COG0789	Transcriptional regulator
DC008_RS06605	COG1960	acyl-CoA dehydrogenase activity
DC008_RS06615	COG0640	Transcriptional regulator
DC008_RS06635	COG3842	ATPase activity
DC008_RS06655	COG2851	Citrate transporter
DC008_RS06660	COG0243	molybdopterin cofactor binding
DC008_RS06665	COG1309	transcriptional regulator
DC008_RS06675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DC008_RS06680	COG2188	Transcriptional regulator
DC008_RS06715	COG1595	DNA-templated transcription, initiation
DC008_RS06735	COG0515	serine threonine protein kinase
DC008_RS06735	COG2815	serine threonine protein kinase
DC008_RS06740	COG2755	lipolytic protein G-D-S-L family
DC008_RS06770	COG1649	PFAM Uncharacterised BCR, COG1649
DC008_RS06770	COG0726	polysaccharide deacetylase
DC008_RS06795	COG1725	Transcriptional regulator
DC008_RS06800	COG0454	-acetyltransferase
DC008_RS06800	COG0456	acetyltransferase
DC008_RS06845	COG0587	DNA-directed DNA polymerase activity
DC008_RS06870	COG1799	cell septum assembly
DC008_RS06875	COG1960	acyl-CoA dehydrogenase activity
DC008_RS06880	COG0477	Major facilitator Superfamily
DC008_RS06890	COG0671	phosphoesterase, PA-phosphatase related
DC008_RS06900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC008_RS06925	COG0411	ABC transporter
DC008_RS06935	COG3583	domain protein
DC008_RS06940	COG1652	LysM domain
DC008_RS06955	COG1160	GTP binding
DC008_RS06965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DC008_RS06990	COG3541	Predicted nucleotidyltransferase
DC008_RS07000	COG0494	nUDIX hydrolase
DC008_RS07005	COG1187	pseudouridine synthase activity
DC008_RS07010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DC008_RS07015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DC008_RS07030	COG0686	Belongs to the AlaDH PNT family
DC008_RS07040	COG0494	nUDIX hydrolase
DC008_RS07045	COG0504	CTP synthase activity
DC008_RS07055	COG3387	PFAM Glycoside hydrolase 15-related
DC008_RS07070	COG0438	transferase activity, transferring glycosyl groups
DC008_RS07080	COG0497	DNA recombination
DC008_RS07085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DC008_RS07105	COG1120	ATPase activity
DC008_RS07110	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC008_RS07115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DC008_RS07120	COG0647	UMP catabolic process
DC008_RS07165	COG1881	PFAM PEBP family protein
DC008_RS07185	COG1119	ATPase activity
DC008_RS07200	COG2197	response regulator
DC008_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS07215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DC008_RS07225	COG1716	ATPase activity
DC008_RS07225	COG1131	(ABC) transporter
DC008_RS07225	COG0842	Transport permease protein
DC008_RS07235	COG3830	Belongs to the UPF0237 family
DC008_RS07235	COG0560	Phosphoserine phosphatase
DC008_RS07240	COG0588	phosphoglycerate mutase activity
DC008_RS07255	COG2807	transmembrane transport
DC008_RS07260	COG2186	Transcriptional regulator
DC008_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS07280	COG0312	modulator of DNA gyrase
DC008_RS07290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DC008_RS07310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DC008_RS07315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DC008_RS07330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC008_RS07340	COG1063	alcohol dehydrogenase
DC008_RS07350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DC008_RS07365	COG3387	PFAM Glycoside hydrolase 15-related
DC008_RS07415	COG0488	(ABC) transporter
DC008_RS07435	COG0235	Class ii aldolase
DC008_RS07455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DC008_RS07460	COG1492	cobalamin metabolic process
DC008_RS07480	COG1797	cobyrinic acid a,c-diamide synthase activity
DC008_RS07540	COG0765	amino acid transport
DC008_RS07550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DC008_RS07555	COG0456	acetyltransferase
DC008_RS07560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DC008_RS07565	COG1917	Cupin 2, conserved barrel domain protein
DC008_RS07570	COG5285	phytanoyl-CoA dioxygenase
DC008_RS07575	COG3844	kynureninase activity
DC008_RS07600	COG1414	Transcriptional regulator
DC008_RS07605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC008_RS07610	COG0768	penicillin binding
DC008_RS07615	COG2252	PERMEase
DC008_RS07660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DC008_RS07665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DC008_RS07685	COG0395	ABC-type sugar transport system, permease component
DC008_RS07690	COG1063	alcohol dehydrogenase
DC008_RS07710	COG1802	Transcriptional regulator
DC008_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS07760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DC008_RS07770	COG1595	DNA-templated transcription, initiation
DC008_RS07780	COG1136	(ABC) transporter
DC008_RS07780	COG0577	efflux transmembrane transporter activity
DC008_RS07790	COG2171	N-acyltransferase activity
DC008_RS07795	COG3226	Transcriptional regulator
DC008_RS07800	COG2076	Multidrug Resistance protein
DC008_RS07815	COG2151	metal-sulfur cluster biosynthetic enzyme
DC008_RS07820	COG0822	iron-sulfur transferase activity
DC008_RS07825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DC008_RS07830	COG0396	ATPase activity
DC008_RS07840	COG0719	Fe-S assembly protein
DC008_RS07855	COG2746	aminoglycoside 3-N-acetyltransferase activity
DC008_RS07890	COG0109	protoheme IX farnesyltransferase activity
DC008_RS07905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DC008_RS07920	COG0363	glucosamine-6-phosphate deaminase activity
DC008_RS07925	COG0395	ABC-type sugar transport system, permease component
DC008_RS07930	COG1175	transmembrane transport
DC008_RS07940	COG0366	Alpha amylase catalytic
DC008_RS07945	COG1653	transport
DC008_RS07950	COG1695	Transcriptional regulator
DC008_RS07955	COG0577	efflux transmembrane transporter activity
DC008_RS07955	COG1136	(ABC) transporter
DC008_RS07965	COG0166	Belongs to the GPI family
DC008_RS07980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DC008_RS07985	COG0149	triose-phosphate isomerase activity
DC008_RS07990	COG0126	phosphoglycerate kinase activity
DC008_RS07995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DC008_RS08005	COG1481	regulation of sporulation
DC008_RS08010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DC008_RS08015	COG1660	Displays ATPase and GTPase activities
DC008_RS08020	COG0322	excinuclease ABC activity
DC008_RS08030	COG1609	Transcriptional regulator
DC008_RS08040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DC008_RS08055	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DC008_RS08060	COG1619	proteins homologs of microcin C7 resistance protein MccF
DC008_RS08065	COG0477	Major facilitator Superfamily
DC008_RS08070	COG0387	Pfam Sodium calcium exchanger
DC008_RS08090	COG0556	nucleotide-excision repair
DC008_RS08100	COG0584	glycerophosphoryl diester phosphodiesterase
DC008_RS08105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DC008_RS08115	COG1063	alcohol dehydrogenase
DC008_RS08125	COG2313	pseudouridylate synthase activity
DC008_RS08130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DC008_RS08130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DC008_RS08135	COG2226	methyltransferase
DC008_RS08140	COG0598	Magnesium transport protein CorA
DC008_RS08170	COG3848	Pyruvate phosphate dikinase
DC008_RS08170	COG0574	Belongs to the PEP-utilizing enzyme family
DC008_RS08210	COG1132	(ABC) transporter
DC008_RS08225	COG0402	S-adenosylhomocysteine deaminase activity
DC008_RS08245	COG0456	acetyltransferase
DC008_RS08275	COG0237	dephospho-CoA kinase activity
DC008_RS08285	COG0539	negative regulation of cytoplasmic translation
DC008_RS08295	COG1643	Atp-dependent helicase
DC008_RS08330	COG2050	protein possibly involved in aromatic compounds catabolism
DC008_RS08355	COG0411	ABC transporter
DC008_RS08390	COG0737	Belongs to the 5'-nucleotidase family
DC008_RS08410	COG0287	Prephenate dehydrogenase
DC008_RS08410	COG1605	Chorismate mutase
DC008_RS08420	COG5640	endopeptidase activity
DC008_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS08440	COG1024	Enoyl-CoA hydratase
DC008_RS08460	COG0183	Belongs to the thiolase family
DC008_RS08465	COG1309	transcriptional regulator
DC008_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS08475	COG1960	acyl-CoA dehydrogenase activity
DC008_RS08480	COG1960	acyl-CoA dehydrogenase activity
DC008_RS08485	COG2304	oxidoreductase activity
DC008_RS08505	COG0070	glutamate synthase
DC008_RS08505	COG0069	glutamate synthase activity
DC008_RS08505	COG0067	glutamate synthase
DC008_RS08515	COG1397	ADP-ribosylglycohydrolase
DC008_RS08535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS08540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC008_RS08550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DC008_RS08560	COG0159	tryptophan synthase activity
DC008_RS08565	COG0133	tryptophan synthase activity
DC008_RS08570	COG0134	indole-3-glycerol-phosphate synthase activity
DC008_RS08590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DC008_RS08595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DC008_RS08605	COG0107	imidazoleglycerol-phosphate synthase activity
DC008_RS08610	COG0251	oxidation-reduction process
DC008_RS08615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DC008_RS08620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DC008_RS08625	COG0131	Imidazoleglycerol-phosphate dehydratase
DC008_RS08630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DC008_RS08635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DC008_RS08655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DC008_RS08675	COG1432	Conserved Protein
DC008_RS08680	COG0587	DNA-directed DNA polymerase activity
DC008_RS08735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DC008_RS08750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DC008_RS08755	COG3599	regulation of cell shape
DC008_RS08765	COG1799	cell septum assembly
DC008_RS08775	COG1496	oxidoreductase activity
DC008_RS08780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DC008_RS08785	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DC008_RS08790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DC008_RS08800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DC008_RS08805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DC008_RS08815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DC008_RS08830	COG0275	rRNA processing
DC008_RS08840	COG0714	Associated with various cellular activities
DC008_RS08860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DC008_RS08870	COG1131	(ABC) transporter
DC008_RS08880	COG1309	transcriptional regulator
DC008_RS08890	COG1233	COG1233 Phytoene dehydrogenase and related
DC008_RS08905	COG0352	thiamine-phosphate diphosphorylase activity
DC008_RS08930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DC008_RS08930	COG2022	thiamine diphosphate biosynthetic process
DC008_RS08940	COG2022	thiamine diphosphate biosynthetic process
DC008_RS08945	COG0515	serine threonine protein kinase
DC008_RS08945	COG2815	serine threonine protein kinase
DC008_RS08950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DC008_RS08960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DC008_RS08965	COG2193	ferroxidase activity
DC008_RS08970	COG0243	molybdopterin cofactor binding
DC008_RS08975	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DC008_RS08990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DC008_RS08995	COG0205	6-phosphofructokinase activity
DC008_RS09000	COG2197	response regulator
DC008_RS09005	COG4585	Histidine kinase
DC008_RS09030	COG1940	carbohydrate kinase activity
DC008_RS09040	COG0003	Pfam Anion-transporting ATPase
DC008_RS09060	COG0438	transferase activity, transferring glycosyl groups
DC008_RS09105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DC008_RS09110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DC008_RS09115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DC008_RS09120	COG0723	plastoquinol--plastocyanin reductase activity
DC008_RS09125	COG2010	Cytochrome c
DC008_RS09130	COG1845	cytochrome c oxidase, subunit III
DC008_RS09140	COG1376	ErfK ybiS ycfS ynhG family protein
DC008_RS09150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC008_RS09155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DC008_RS09165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS09190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DC008_RS09195	COG0515	serine threonine protein kinase
DC008_RS09195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC008_RS09200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DC008_RS09205	COG2197	response regulator
DC008_RS09235	COG2226	methyltransferase
DC008_RS09240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DC008_RS09260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DC008_RS09275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DC008_RS09285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DC008_RS09290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DC008_RS09295	COG0508	dehydrogenase complex catalyzes the overall conversion of
DC008_RS09305	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DC008_RS09335	COG1090	epimerase
DC008_RS09350	COG0321	lipoyl(octanoyl) transferase activity
DC008_RS09355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DC008_RS09375	COG0174	glutamine synthetase
DC008_RS09385	COG0501	Belongs to the peptidase M48B family
DC008_RS09430	COG0745	RESPONSE REGULATOR receiver
DC008_RS09480	COG0366	Alpha amylase catalytic
DC008_RS09485	COG3833	ABC-type maltose transport systems, permease component
DC008_RS09490	COG1175	transmembrane transport
DC008_RS09500	COG1609	Transcriptional regulator
DC008_RS09510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DC008_RS09520	COG0745	RESPONSE REGULATOR receiver
DC008_RS09530	COG2409	Drug exporters of the RND superfamily
DC008_RS09545	COG3629	intracellular signal transduction
DC008_RS09545	COG3903	Transcriptional regulator
DC008_RS09555	COG0174	glutamine synthetase
DC008_RS09565	COG1959	2 iron, 2 sulfur cluster binding
DC008_RS09580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DC008_RS09585	COG0477	Major facilitator Superfamily
DC008_RS09615	COG1994	Peptidase M50
DC008_RS09665	COG2837	iron assimilation
DC008_RS09670	COG0672	)-iron permease
DC008_RS09695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC008_RS09700	COG2814	Major facilitator Superfamily
DC008_RS09710	COG3540	Alkaline phosphatase
DC008_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS09725	COG2259	Doxx family
DC008_RS09785	COG0557	exoribonuclease II activity
DC008_RS09790	COG3022	response to hydroperoxide
DC008_RS09795	COG0800	Aldolase
DC008_RS09810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DC008_RS09830	COG2030	dehydratase
DC008_RS09835	COG4585	Histidine kinase
DC008_RS09840	COG2197	response regulator
DC008_RS09855	COG0477	Major facilitator Superfamily
DC008_RS09865	COG0860	N-Acetylmuramoyl-L-alanine amidase
DC008_RS09875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS09895	COG0438	transferase activity, transferring glycosyl groups
DC008_RS09900	COG1309	transcriptional regulator
DC008_RS09940	COG3845	ABC transporter
DC008_RS09955	COG2124	cytochrome p450
DC008_RS09960	COG0183	Belongs to the thiolase family
DC008_RS09975	COG4122	O-methyltransferase activity
DC008_RS10015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DC008_RS10085	COG1358	cellular component organization or biogenesis
DC008_RS10130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DC008_RS10140	COG0477	Major facilitator Superfamily
DC008_RS10145	COG1309	transcriptional regulator
DC008_RS10160	COG0667	Aldo Keto reductase
DC008_RS10165	COG0789	Transcriptional regulator
DC008_RS10175	COG2409	Drug exporters of the RND superfamily
DC008_RS10195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC008_RS10200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC008_RS10205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC008_RS10245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC008_RS10250	COG1764	response to oxidative stress
DC008_RS10255	COG2130	NADP-dependent
DC008_RS10275	COG4948	Mandelate Racemase Muconate Lactonizing
DC008_RS10295	COG1129	ABC transporter
DC008_RS10300	COG4214	carbohydrate transport
DC008_RS10310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DC008_RS10320	COG0443	Heat shock 70 kDa protein
DC008_RS10350	COG3386	PFAM SMP-30 Gluconolaconase
DC008_RS10355	COG1414	Transcriptional regulator
DC008_RS10385	COG4981	capsule polysaccharide biosynthetic process
DC008_RS10435	COG2186	Transcriptional regulator
DC008_RS10445	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS10450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DC008_RS10450	COG0825	malonyl-CoA metabolic process
DC008_RS10455	COG1077	Cell shape determining protein MreB Mrl
DC008_RS10495	COG1070	Carbohydrate kinase
DC008_RS10510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DC008_RS10520	COG0358	DNA primase activity
DC008_RS10530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DC008_RS10540	COG2949	membrane
DC008_RS10545	COG0243	molybdopterin cofactor binding
DC008_RS10580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC008_RS10585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DC008_RS10585	COG2146	nitrite reductase [NAD(P)H] activity
DC008_RS10615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DC008_RS10615	COG0574	Belongs to the PEP-utilizing enzyme family
DC008_RS10620	COG1846	Transcriptional regulator
DC008_RS10620	COG1940	carbohydrate kinase activity
DC008_RS10625	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DC008_RS10650	COG1136	(ABC) transporter
DC008_RS10665	COG0456	acetyltransferase
DC008_RS10675	COG0667	Aldo Keto reductase
DC008_RS10695	COG0423	glycine-tRNA ligase activity
DC008_RS10700	COG3443	Belongs to the bacterial solute-binding protein 9 family
DC008_RS10700	COG0803	Belongs to the bacterial solute-binding protein 9 family
DC008_RS10705	COG1121	(ABC) transporter
DC008_RS10710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DC008_RS10720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DC008_RS10725	COG1381	Involved in DNA repair and RecF pathway recombination
DC008_RS10780	COG0456	acetyltransferase
DC008_RS10810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DC008_RS10825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DC008_RS10845	COG2723	6-phospho-beta-galactosidase activity
DC008_RS10870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DC008_RS10880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DC008_RS10890	COG2315	Protein conserved in bacteria
DC008_RS10915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS10920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DC008_RS10925	COG1414	Transcriptional regulator
DC008_RS10935	COG1234	tRNA 3'-trailer cleavage
DC008_RS10940	COG0537	adenosine 5'-monophosphoramidase activity
DC008_RS10945	COG4946	Tricorn protease homolog
DC008_RS10945	COG0793	Belongs to the peptidase S41A family
DC008_RS10965	COG0484	heat shock protein binding
DC008_RS10970	COG1420	regulation of RNA biosynthetic process
DC008_RS10995	COG0784	Response regulator, receiver
DC008_RS10995	COG2205	protein histidine kinase activity
DC008_RS11010	COG0481	GTPase activity
DC008_RS11015	COG0268	Binds directly to 16S ribosomal RNA
DC008_RS11045	COG1596	polysaccharide export
DC008_RS11045	COG1555	photosystem II stabilization
DC008_RS11050	COG1307	EDD domain protein, DegV family
DC008_RS11060	COG0495	leucyl-tRNA aminoacylation
DC008_RS11075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DC008_RS11100	COG0588	phosphoglycerate mutase activity
DC008_RS11105	COG0799	negative regulation of ribosome biogenesis
DC008_RS11115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DC008_RS11125	COG0501	Belongs to the peptidase M48B family
DC008_RS11140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DC008_RS11150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DC008_RS11165	COG0463	Glycosyl transferase, family 2
DC008_RS11180	COG3540	Alkaline phosphatase
DC008_RS11195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DC008_RS11200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DC008_RS11205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DC008_RS11210	COG1530	ribonuclease E activity
DC008_RS11255	COG0772	Belongs to the SEDS family
DC008_RS11275	COG1077	Cell shape determining protein MreB Mrl
DC008_RS11280	COG0105	UTP biosynthetic process
DC008_RS11290	COG0285	dihydrofolate synthase activity
DC008_RS11295	COG0525	valine-tRNA ligase activity
DC008_RS11305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DC008_RS11310	COG0740	serine-type endopeptidase activity
DC008_RS11315	COG0740	serine-type endopeptidase activity
DC008_RS11320	COG0544	peptidyl-prolyl cis-trans isomerase activity
DC008_RS11355	COG0508	dehydrogenase complex catalyzes the overall conversion of
DC008_RS11355	COG0596	Alpha beta hydrolase
DC008_RS11370	COG3594	Acyltransferase
DC008_RS11385	COG4552	Acetyltransferase involved in intracellular survival and related
DC008_RS11400	COG1113	amino acid transport
DC008_RS11420	COG1268	BioY protein
DC008_RS11425	COG1940	carbohydrate kinase activity
DC008_RS11435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC008_RS11440	COG1116	anion transmembrane transporter activity
DC008_RS11445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS11455	COG1113	amino acid transport
DC008_RS11460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DC008_RS11470	COG0588	phosphoglycerate mutase activity
DC008_RS11480	COG1653	transport
DC008_RS11485	COG1175	transmembrane transport
DC008_RS11490	COG0395	ABC-type sugar transport system, permease component
DC008_RS11495	COG3842	ATPase activity
DC008_RS11500	COG1349	DNA-binding transcription factor activity
DC008_RS11520	COG0584	glycerophosphoryl diester phosphodiesterase
DC008_RS11530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DC008_RS11560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC008_RS11605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DC008_RS11630	COG1595	DNA-templated transcription, initiation
DC008_RS11640	COG1131	(ABC) transporter
DC008_RS11660	COG0668	transmembrane transport
DC008_RS11680	COG1175	transmembrane transport
DC008_RS11685	COG0395	ABC-type sugar transport system, permease component
DC008_RS11690	COG1486	melibiose metabolic process
DC008_RS11705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC008_RS11735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DC008_RS11740	COG2346	COG2346, Truncated hemoglobins
DC008_RS11765	COG0629	single-stranded DNA binding
DC008_RS11885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DC008_RS11945	COG0438	transferase activity, transferring glycosyl groups
DC008_RS11960	COG0728	peptidoglycan biosynthetic process
DC008_RS11970	COG0438	transferase activity, transferring glycosyl groups
DC008_RS12030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS12040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC008_RS12050	COG2409	Drug exporters of the RND superfamily
DC008_RS12075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DC008_RS12110	COG1129	ABC transporter
DC008_RS12115	COG1879	ABC-type sugar transport system periplasmic component
DC008_RS12120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS12125	COG1869	D-ribose catabolic process
DC008_RS12150	COG1609	Transcriptional regulator
DC008_RS12165	COG1472	Belongs to the glycosyl hydrolase 3 family
DC008_RS12190	COG2356	endonuclease I
DC008_RS12195	COG0028	Belongs to the TPP enzyme family
DC008_RS12205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DC008_RS12225	COG1946	Acyl-CoA thioesterase
DC008_RS12235	COG1309	transcriptional regulator
DC008_RS12240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC008_RS12255	COG1960	acyl-CoA dehydrogenase activity
DC008_RS12275	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DC008_RS12305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DC008_RS12310	COG0589	response to stress
DC008_RS12320	COG4977	sequence-specific DNA binding
DC008_RS12325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DC008_RS12345	COG1175	transmembrane transport
DC008_RS12370	COG0745	RESPONSE REGULATOR receiver
DC008_RS12395	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DC008_RS12410	COG0588	phosphoglycerate mutase activity
DC008_RS12460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC008_RS12495	COG0765	amino acid transport
DC008_RS12500	COG0765	amino acid transport
DC008_RS12505	COG1126	abc transporter atp-binding protein
DC008_RS12525	COG3397	chitin binding
DC008_RS12585	COG0673	inositol 2-dehydrogenase activity
DC008_RS12590	COG4702	Belongs to the UPF0303 family
DC008_RS12595	COG0179	Fumarylacetoacetate (FAA) hydrolase
DC008_RS12600	COG0706	membrane insertase activity
DC008_RS12640	COG0270	DNA (cytosine-5-)-methyltransferase activity
DC008_RS12695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS12710	COG2733	membrane
DC008_RS12725	COG4555	ABC transporter
DC008_RS12740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC008_RS12780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DC008_RS12790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DC008_RS12795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DC008_RS12800	COG1263	PTS System
DC008_RS12805	COG1263	PTS System
DC008_RS12810	COG1234	tRNA 3'-trailer cleavage
DC008_RS12840	COG1113	amino acid transport
DC008_RS12850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DC008_RS12860	COG1335	isochorismatase
DC008_RS12895	COG0277	FAD linked oxidase domain protein
DC008_RS12905	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DC008_RS12915	COG1174	glycine betaine transport
DC008_RS12925	COG1174	glycine betaine transport
DC008_RS12940	COG4948	Mandelate Racemase Muconate Lactonizing
DC008_RS13005	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DC008_RS13010	COG0395	ABC-type sugar transport system, permease component
DC008_RS13030	COG1678	Uncharacterized ACR, COG1678
DC008_RS13035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DC008_RS13040	COG0776	regulation of translation
DC008_RS13050	COG3973	AAA domain
DC008_RS13075	COG2223	nitrite transmembrane transporter activity
DC008_RS13115	COG0583	DNA-binding transcription factor activity
DC008_RS13130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC008_RS13140	COG2814	Major facilitator Superfamily
DC008_RS13175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC008_RS13190	COG4770	biotin carboxylase activity
DC008_RS13195	COG0745	RESPONSE REGULATOR receiver
DC008_RS13220	COG0745	RESPONSE REGULATOR receiver
DC008_RS13235	COG0475	glutathione-regulated potassium exporter activity
DC008_RS13245	COG1733	regulation of RNA biosynthetic process
DC008_RS13285	COG0702	epimerase
DC008_RS13290	COG2027	D-alanyl-D-alanine carboxypeptidase
DC008_RS13315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DC008_RS13320	COG0793	Belongs to the peptidase S41A family
DC008_RS13330	COG2884	Cell division ATP-binding protein ftsE
DC008_RS13345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DC008_RS13350	COG0515	serine threonine protein kinase
DC008_RS13355	COG0515	serine threonine protein kinase
DC008_RS13370	COG1175	transmembrane transport
DC008_RS13375	COG0395	ABC-type sugar transport system, permease component
DC008_RS13380	COG1216	Glycosyl transferase, family 2
DC008_RS13385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DC008_RS13390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DC008_RS13400	COG1764	response to oxidative stress
DC008_RS13405	COG1846	Transcriptional regulator
DC008_RS13410	COG1215	transferase activity, transferring glycosyl groups
DC008_RS13430	COG1134	teichoic acid transport
DC008_RS13435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DC008_RS13440	COG1215	transferase activity, transferring glycosyl groups
DC008_RS13450	COG2902	Dehydrogenase
DC008_RS13475	COG0653	protein targeting
DC008_RS13485	COG3214	Protein conserved in bacteria
DC008_RS13490	COG2197	response regulator
DC008_RS13495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DC008_RS13510	COG0823	Involved in the tonB-independent uptake of proteins
DC008_RS13515	COG5002	protein histidine kinase activity
DC008_RS13520	COG0745	RESPONSE REGULATOR receiver
DC008_RS13525	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DC008_RS13545	COG0714	Associated with various cellular activities
DC008_RS13590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DC008_RS13600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DC008_RS13600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DC008_RS13600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DC008_RS13610	COG1482	cell wall glycoprotein biosynthetic process
DC008_RS13620	COG2835	tetraacyldisaccharide 4'-kinase activity
DC008_RS13625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DC008_RS13630	COG1620	l-lactate permease
DC008_RS13670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DC008_RS13675	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DC008_RS13675	COG0778	Nitroreductase
DC008_RS13700	COG1316	TRANSCRIPTIONal
DC008_RS13705	COG1316	TRANSCRIPTIONal
DC008_RS13710	COG1316	TRANSCRIPTIONal
DC008_RS13720	COG0463	Glycosyl transferase, family 2
DC008_RS13725	COG1316	TRANSCRIPTIONal
DC008_RS13735	COG1316	TRANSCRIPTIONal
DC008_RS13750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DC008_RS13780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DC008_RS13795	COG2205	protein histidine kinase activity
DC008_RS13800	COG0745	RESPONSE REGULATOR receiver
DC008_RS13805	COG3104	oligopeptide transport
DC008_RS13835	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS13840	COG1191	sigma factor activity
DC008_RS13850	COG1228	amidohydrolase
DC008_RS13865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DC008_RS13905	COG2986	histidine ammonia-lyase
DC008_RS13920	COG2755	lipolytic protein G-D-S-L family
DC008_RS13925	COG0183	Belongs to the thiolase family
DC008_RS13960	COG1136	(ABC) transporter
DC008_RS13965	COG0577	efflux transmembrane transporter activity
DC008_RS13965	COG1136	(ABC) transporter
DC008_RS13970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC008_RS13975	COG1252	NADH dehydrogenase
DC008_RS14005	COG0148	phosphopyruvate hydratase activity
DC008_RS14020	COG2124	cytochrome p450
DC008_RS14080	COG0577	efflux transmembrane transporter activity
DC008_RS14085	COG1136	(ABC) transporter
DC008_RS14110	COG0745	RESPONSE REGULATOR receiver
DC008_RS14115	COG2205	protein histidine kinase activity
DC008_RS14125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DC008_RS14155	COG4585	Histidine kinase
DC008_RS14165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DC008_RS14170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DC008_RS14175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DC008_RS14180	COG0193	aminoacyl-tRNA hydrolase activity
DC008_RS14195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DC008_RS14205	COG1309	transcriptional regulator
DC008_RS14220	COG4106	trans-aconitate 2-methyltransferase activity
DC008_RS14225	COG1846	Transcriptional regulator
DC008_RS14230	COG2197	response regulator
DC008_RS14240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DC008_RS14280	COG0488	(ABC) transporter
DC008_RS14290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DC008_RS14295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DC008_RS14300	COG3583	domain protein
DC008_RS14300	COG3584	3D domain protein
DC008_RS14305	COG0084	hydrolase, TatD family'
DC008_RS14325	COG0768	penicillin binding
DC008_RS14340	COG0310	cobalt ion transport
DC008_RS14350	COG1122	ATPase activity
DC008_RS14355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC008_RS14365	COG0537	adenosine 5'-monophosphoramidase activity
DC008_RS14385	COG0442	prolyl-tRNA aminoacylation
DC008_RS14390	COG2409	Drug exporters of the RND superfamily
DC008_RS14400	COG4946	Tricorn protease homolog
DC008_RS14400	COG0793	Belongs to the peptidase S41A family
DC008_RS14410	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS14415	COG2267	carboxylic ester hydrolase activity
DC008_RS14420	COG2072	flavoprotein involved in K transport
DC008_RS14430	COG0708	Exodeoxyribonuclease III
DC008_RS14450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC008_RS14455	COG0521	Mo-molybdopterin cofactor biosynthetic process
DC008_RS14455	COG0315	cyclic pyranopterin monophosphate synthase activity
DC008_RS14460	COG0315	cyclic pyranopterin monophosphate synthase activity
DC008_RS14470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DC008_RS14475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DC008_RS14485	COG3263	regulation of cellular component size
DC008_RS14500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DC008_RS14510	COG1970	mechanosensitive ion channel activity
DC008_RS14525	COG3191	aminopeptidase activity
DC008_RS14530	COG1376	ErfK ybiS ycfS ynhG family protein
DC008_RS14545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DC008_RS14545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DC008_RS14555	COG1349	DNA-binding transcription factor activity
DC008_RS14590	COG0477	Major facilitator Superfamily
DC008_RS14610	COG3384	dioxygenase
DC008_RS14635	COG1414	Transcriptional regulator
DC008_RS14660	COG1278	Cold shock
DC008_RS14665	COG0513	Belongs to the DEAD box helicase family
DC008_RS14690	COG2197	response regulator
DC008_RS14710	COG0386	Belongs to the glutathione peroxidase family
DC008_RS14735	COG1686	Belongs to the peptidase S11 family
DC008_RS14780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DC008_RS14810	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS14815	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DC008_RS14865	COG1024	Enoyl-CoA hydratase
DC008_RS14875	COG0515	serine threonine protein kinase
DC008_RS14875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC008_RS14895	COG1522	sequence-specific DNA binding
DC008_RS14905	COG1960	acyl-CoA dehydrogenase activity
DC008_RS14920	COG0259	pyridoxamine-phosphate oxidase activity
DC008_RS14950	COG1595	DNA-templated transcription, initiation
DC008_RS14955	COG2072	flavoprotein involved in K transport
DC008_RS14965	COG1024	Enoyl-CoA hydratase
DC008_RS14970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DC008_RS14975	COG2814	Major facilitator Superfamily
DC008_RS14980	COG4977	sequence-specific DNA binding
DC008_RS14995	COG1960	acyl-CoA dehydrogenase activity
DC008_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS15020	COG1960	acyl-CoA dehydrogenase activity
DC008_RS15025	COG1960	acyl-CoA dehydrogenase activity
DC008_RS15045	COG1595	DNA-templated transcription, initiation
DC008_RS15080	COG1131	(ABC) transporter
DC008_RS15090	COG0596	Alpha beta hydrolase
DC008_RS15090	COG2945	thiolester hydrolase activity
DC008_RS15105	COG4821	SIS domain
DC008_RS15120	COG0259	pyridoxamine-phosphate oxidase activity
DC008_RS15130	COG0515	serine threonine protein kinase
DC008_RS15130	COG2815	serine threonine protein kinase
DC008_RS15145	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS15160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC008_RS15185	COG5006	permease, DMT superfamily
DC008_RS15195	COG0277	FAD linked oxidase domain protein
DC008_RS15195	COG0247	lactate metabolic process
DC008_RS15200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DC008_RS15205	COG0596	Alpha beta hydrolase
DC008_RS15240	COG0667	Aldo Keto reductase
DC008_RS15265	COG2252	PERMEase
DC008_RS15275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DC008_RS15305	COG2814	Major facilitator Superfamily
DC008_RS15315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DC008_RS15320	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DC008_RS15325	COG1278	Cold shock
DC008_RS15350	COG1061	Type III restriction enzyme res subunit
DC008_RS15360	COG3973	AAA domain
DC008_RS15400	COG1737	Transcriptional regulator
DC008_RS15405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DC008_RS15425	COG2318	DinB family
DC008_RS15440	COG0459	protein refolding
DC008_RS15460	COG0463	Glycosyl transferase, family 2
DC008_RS15490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DC008_RS15495	COG1105	Belongs to the carbohydrate kinase PfkB family
DC008_RS15595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DC008_RS15660	COG3842	ATPase activity
DC008_RS15680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DC008_RS15685	COG0215	cysteine-tRNA ligase activity
DC008_RS15690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DC008_RS15695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DC008_RS15700	COG1329	Transcriptional regulator
DC008_RS15720	COG5002	protein histidine kinase activity
DC008_RS15735	COG3290	protein histidine kinase activity
DC008_RS15745	COG4221	oxidoreductase activity
DC008_RS15755	COG0222	ribosome binding
DC008_RS15765	COG0588	phosphoglycerate mutase activity
DC008_RS15795	COG0438	transferase activity, transferring glycosyl groups
DC008_RS15865	COG3973	AAA domain
DC008_RS15885	COG0546	phosphoglycolate phosphatase activity
DC008_RS15900	COG2188	Transcriptional regulator
DC008_RS15910	COG2188	Transcriptional regulator
DC008_RS15915	COG4552	Acetyltransferase involved in intracellular survival and related
DC008_RS15925	COG1490	D-aminoacyl-tRNA deacylase activity
DC008_RS15930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DC008_RS15940	COG3485	protocatechuate 3,4-dioxygenase
DC008_RS15985	COG2897	thiosulfate sulfurtransferase activity
DC008_RS16010	COG0745	RESPONSE REGULATOR receiver
DC008_RS16015	COG1609	Transcriptional regulator
DC008_RS16020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DC008_RS16025	COG0745	RESPONSE REGULATOR receiver
DC008_RS16050	COG0737	Belongs to the 5'-nucleotidase family
DC008_RS16055	COG0456	acetyltransferase
DC008_RS16065	COG1725	Transcriptional regulator
DC008_RS16080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DC008_RS16110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DC008_RS16115	COG0306	phosphate transporter
DC008_RS16125	COG1937	Protein conserved in bacteria
DC008_RS16135	COG0277	FAD linked oxidase domain protein
DC008_RS16140	COG0671	phosphoesterase, PA-phosphatase related
DC008_RS16145	COG0741	lytic transglycosylase activity
DC008_RS16145	COG0739	heme binding
DC008_RS16145	COG1196	nuclear chromosome segregation
DC008_RS16160	COG1846	Transcriptional regulator
DC008_RS16200	COG4585	Histidine kinase
DC008_RS16205	COG2197	response regulator
DC008_RS16230	COG1846	Transcriptional regulator
DC008_RS16245	COG1252	NADH dehydrogenase
DC008_RS16290	COG0579	oxidoreductase
DC008_RS16295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DC008_RS16315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DC008_RS16315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DC008_RS16325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DC008_RS16375	COG0513	Belongs to the DEAD box helicase family
DC008_RS16410	COG1643	Atp-dependent helicase
DC008_RS16435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DC008_RS16445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DC008_RS16460	COG3340	Belongs to the peptidase S51 family
DC008_RS16475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DC008_RS16480	COG0047	phosphoribosylformylglycinamidine synthase activity
DC008_RS16485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DC008_RS16520	COG2197	response regulator
DC008_RS16535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DC008_RS16590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DC008_RS16600	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS16635	COG0433	COG0433 Predicted ATPase
DC008_RS16650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DC008_RS16740	COG2188	Transcriptional regulator
DC008_RS16775	COG1191	sigma factor activity
DC008_RS16780	COG1191	sigma factor activity
DC008_RS16800	COG0477	Major facilitator Superfamily
DC008_RS16805	COG2353	YceI-like domain
DC008_RS16810	COG3467	pyridoxamine 5'-phosphate
DC008_RS16820	COG0477	Major facilitator Superfamily
DC008_RS16825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DC008_RS16840	COG1309	transcriptional regulator
DC008_RS16845	COG2205	protein histidine kinase activity
DC008_RS16850	COG0745	RESPONSE REGULATOR receiver
DC008_RS16865	COG1846	Transcriptional regulator
DC008_RS16875	COG1349	DNA-binding transcription factor activity
DC008_RS16985	COG0784	Response regulator, receiver
DC008_RS16990	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS16995	COG1595	DNA-templated transcription, initiation
DC008_RS17035	COG0789	Transcriptional regulator
DC008_RS17080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DC008_RS17100	COG0653	protein targeting
DC008_RS17120	COG0006	proline dipeptidase activity
DC008_RS17145	COG1136	(ABC) transporter
DC008_RS17175	COG1999	signal sequence binding
DC008_RS17190	COG2837	iron assimilation
DC008_RS17200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DC008_RS17205	COG0561	phosphatase activity
DC008_RS17230	COG1131	(ABC) transporter
DC008_RS17240	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DC008_RS17255	COG0561	phosphatase activity
DC008_RS17260	COG0741	lytic transglycosylase activity
DC008_RS17260	COG1196	nuclear chromosome segregation
DC008_RS17260	COG0739	heme binding
DC008_RS17265	COG4988	ABC transporter
DC008_RS17270	COG1294	oxidase, subunit
DC008_RS17275	COG1271	oxidase subunit
DC008_RS17280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DC008_RS17285	COG1609	Transcriptional regulator
DC008_RS17305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DC008_RS17330	COG0662	Cupin 2, conserved barrel domain protein
DC008_RS17335	COG1950	PFAM Membrane protein of
DC008_RS17340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC008_RS17345	COG0626	cystathionine gamma-synthase activity
DC008_RS17370	COG2814	Major facilitator Superfamily
DC008_RS17390	COG0187	DNA topoisomerase II activity
DC008_RS17395	COG0305	Participates in initiation and elongation during chromosome replication
DC008_RS17405	COG0359	binds to the 23S rRNA
DC008_RS17410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DC008_RS17415	COG0629	single-stranded DNA binding
DC008_RS17420	COG0360	Binds together with S18 to 16S ribosomal RNA
DC008_RS17445	COG4499	WXG100 protein secretion system (Wss), protein YukC
DC008_RS17445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC008_RS17455	COG1260	myo-inositol-1-phosphate synthase
DC008_RS17475	COG0617	tRNA 3'-terminal CCA addition
DC008_RS17490	COG0515	serine threonine protein kinase
DC008_RS17490	COG2815	serine threonine protein kinase
DC008_RS17495	COG1595	DNA-templated transcription, initiation
DC008_RS17505	COG0492	ferredoxin-NADP+ reductase activity
DC008_RS17510	COG3118	belongs to the thioredoxin family
DC008_RS17525	COG1192	Involved in chromosome partitioning
DC008_RS17530	COG0357	Ribosomal RNA small subunit methyltransferase G
DC008_RS17540	COG0706	membrane insertase activity
DC008_RS17545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DC008_RS17550	COG0594	ribonuclease P activity
DC008_RS17555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DC008_RS17560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DC008_RS17570	COG0592	DNA-directed DNA polymerase activity
DC008_RS17575	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DC008_RS17580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DC008_RS17585	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DC008_RS17590	COG0187	DNA topoisomerase II activity
DC008_RS17595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DC008_RS17620	COG1116	anion transmembrane transporter activity
DC008_RS17665	COG0705	Rhomboid family
DC008_RS17680	COG3764	Sortase (surface protein transpeptidase)
DC008_RS17695	COG3764	Sortase (surface protein transpeptidase)
DC008_RS17700	COG3764	Sortase (surface protein transpeptidase)
DC008_RS17705	COG0515	serine threonine protein kinase
DC008_RS17715	COG0768	penicillin binding
DC008_RS17730	COG1716	ATPase activity
DC008_RS17735	COG1716	ATPase activity
DC008_RS17745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DC008_RS17750	COG1733	regulation of RNA biosynthetic process
DC008_RS17795	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC008_RS17800	COG1309	transcriptional regulator
DC008_RS17805	COG1522	sequence-specific DNA binding
DC008_RS17825	COG0746	molybdenum cofactor guanylyltransferase activity
DC008_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS17850	COG3321	synthase
DC008_RS17850	COG0604	alcohol dehydrogenase
DC008_RS17865	COG0515	serine threonine protein kinase
DC008_RS17870	COG0515	serine threonine protein kinase
DC008_RS17880	COG0022	dehydrogenase e1 component
DC008_RS17885	COG0508	dehydrogenase complex catalyzes the overall conversion of
DC008_RS17935	COG1362	aminopeptidase activity
DC008_RS17940	COG1960	acyl-CoA dehydrogenase activity
DC008_RS17950	COG1741	Belongs to the pirin family
DC008_RS17965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DC008_RS18015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DC008_RS18030	COG0583	DNA-binding transcription factor activity
DC008_RS18075	COG0222	ribosome binding
DC008_RS18085	COG1957	nucleoside hydrolase
DC008_RS18095	COG0366	Alpha amylase catalytic
DC008_RS18255	COG2188	Transcriptional regulator
DC008_RS18270	COG0717	Belongs to the dCTP deaminase family
DC008_RS18290	COG0640	Transcriptional regulator
DC008_RS18300	COG1136	(ABC) transporter
DC008_RS18300	COG4591	ABC-type transport system involved in lipoprotein release permease component
DC008_RS18365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DC008_RS18390	COG1801	Protein of unknown function DUF72
DC008_RS18420	COG2181	nitrate reductase activity
DC008_RS18420	COG0247	lactate metabolic process
DC008_RS18430	COG0443	Heat shock 70 kDa protein
DC008_RS18435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DC008_RS18440	COG0484	heat shock protein binding
DC008_RS18445	COG0789	Transcriptional regulator
DC008_RS18485	COG0542	response to heat
DC008_RS18550	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DC008_RS18565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DC008_RS18570	COG0191	fructose-bisphosphate aldolase activity
DC008_RS18575	COG0477	Major facilitator Superfamily
DC008_RS18585	COG3483	tryptophan 2,3-dioxygenase activity
DC008_RS18590	COG3844	kynureninase activity
DC008_RS18600	COG4585	Histidine kinase
DC008_RS18605	COG2197	response regulator
DC008_RS18625	COG3559	Exporter of polyketide antibiotics
DC008_RS18630	COG1131	(ABC) transporter
DC008_RS18645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DC008_RS18660	COG4585	Histidine kinase
DC008_RS18665	COG2197	response regulator
DC008_RS18695	COG1802	Transcriptional regulator
DC008_RS18700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DC008_RS18705	COG0693	protein deglycase activity
DC008_RS18725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DC008_RS18730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DC008_RS18750	COG1595	DNA-templated transcription, initiation
DC008_RS18785	COG4249	Peptidase C14 caspase catalytic subunit p20
DC008_RS18785	COG2319	Wd-40 repeat
DC008_RS18830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DC008_RS18845	COG1316	TRANSCRIPTIONal
DC008_RS18875	COG1487	ribonuclease activity
DC008_RS18940	COG1674	ftsk spoiiie
DC008_RS19005	COG1408	metallophosphoesterase
DC008_RS19015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC008_RS19030	COG0003	Pfam Anion-transporting ATPase
DC008_RS19050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DC008_RS19085	COG0596	Alpha beta hydrolase
DC008_RS19100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DC008_RS19170	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS19175	COG2172	sigma factor antagonist activity
DC008_RS19180	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DC008_RS19195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DC008_RS19195	COG1754	DNA topoisomerase type I activity
DC008_RS19200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DC008_RS19245	COG4249	Peptidase C14 caspase catalytic subunit p20
DC008_RS19245	COG2319	Wd-40 repeat
DC008_RS19270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DC008_RS19270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DC008_RS19310	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS19330	COG0076	glutamate decarboxylase activity
DC008_RS19335	COG0789	Transcriptional regulator
DC008_RS19340	COG0393	Putative heavy-metal-binding
DC008_RS19345	COG0586	Pfam SNARE associated Golgi protein
DC008_RS19355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DC008_RS19360	COG2027	D-alanyl-D-alanine carboxypeptidase
DC008_RS19370	COG0037	tRNA processing
DC008_RS19385	COG0302	gtp cyclohydrolase
DC008_RS19400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DC008_RS19440	COG0649	NAD binding
DC008_RS19455	COG2197	response regulator
DC008_RS19460	COG1660	Displays ATPase and GTPase activities
DC008_RS19465	COG0640	Transcriptional regulator
DC008_RS19480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DC008_RS19485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DC008_RS19495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DC008_RS19515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DC008_RS19545	COG0739	heme binding
DC008_RS19560	COG2205	protein histidine kinase activity
DC008_RS19565	COG0745	RESPONSE REGULATOR receiver
DC008_RS19575	COG1595	DNA-templated transcription, initiation
DC008_RS19590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DC008_RS19610	COG0248	Ppx GppA phosphatase
DC008_RS19615	COG1082	Xylose isomerase domain protein TIM barrel
DC008_RS19625	COG0129	dihydroxy-acid dehydratase activity
DC008_RS19635	COG4991	sh3 domain protein
DC008_RS19650	COG0842	Transport permease protein
DC008_RS19650	COG1129	ABC transporter
DC008_RS19660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DC008_RS19665	COG0180	Tryptophanyl-tRNA synthetase
DC008_RS19690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DC008_RS19705	COG0123	including yeast histone deacetylase and acetoin utilization protein
DC008_RS19755	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DC008_RS19760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DC008_RS19765	COG0181	hydroxymethylbilane synthase activity
DC008_RS19770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DC008_RS19770	COG1648	precorrin-2 dehydrogenase activity
DC008_RS19795	COG0113	porphobilinogen synthase activity
DC008_RS19825	COG0018	arginyl-trna synthetase
DC008_RS19830	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DC008_RS19850	COG1690	Belongs to the RtcB family
DC008_RS19865	COG1742	UPF0060 membrane protein
DC008_RS19870	COG1733	regulation of RNA biosynthetic process
DC008_RS19875	COG0604	alcohol dehydrogenase
DC008_RS19890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS19915	COG0492	ferredoxin-NADP+ reductase activity
DC008_RS19920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC008_RS19925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC008_RS19930	COG0640	Transcriptional regulator
DC008_RS19935	COG0798	PFAM Bile acid sodium symporter
DC008_RS19955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DC008_RS19960	COG0406	alpha-ribazole phosphatase activity
DC008_RS19975	COG0785	Cytochrome C biogenesis protein
DC008_RS19980	COG1333	cytochrome c biogenesis protein
DC008_RS19985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DC008_RS20015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DC008_RS20030	COG0163	prenyltransferase activity
DC008_RS20040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DC008_RS20060	COG4585	Histidine kinase
DC008_RS20065	COG2197	response regulator
DC008_RS20090	COG1309	transcriptional regulator
DC008_RS20105	COG0183	Belongs to the thiolase family
DC008_RS20115	COG4213	ABC transporter substrate-binding protein
DC008_RS20120	COG4106	trans-aconitate 2-methyltransferase activity
DC008_RS20140	COG1396	sequence-specific DNA binding
DC008_RS20145	COG1278	Cold shock
DC008_RS20150	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DC008_RS20165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DC008_RS20175	COG2226	methyltransferase
DC008_RS20205	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC008_RS20210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC008_RS20215	COG0649	NAD binding
DC008_RS20230	COG1034	ATP synthesis coupled electron transport
DC008_RS20235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DC008_RS20240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC008_RS20245	COG0839	Belongs to the complex I subunit 6 family
DC008_RS20250	COG0713	ATP synthesis coupled electron transport
DC008_RS20255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DC008_RS20265	COG1007	ATP synthesis coupled electron transport
DC008_RS20270	COG0514	ATP-dependent DNA helicase (RecQ)
DC008_RS20290	COG0561	phosphatase activity
DC008_RS20300	COG0142	geranyltranstransferase activity
DC008_RS20310	COG0655	NAD(P)H dehydrogenase (quinone) activity
DC008_RS20335	COG4935	Belongs to the peptidase S8 family
DC008_RS20335	COG2234	aminopeptidase activity
DC008_RS20350	COG0702	epimerase
DC008_RS20355	COG1733	regulation of RNA biosynthetic process
DC008_RS20360	COG1013	pyruvate-flavodoxin oxidoreductase activity
DC008_RS20365	COG0674	pyruvate-flavodoxin oxidoreductase activity
DC008_RS20365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DC008_RS20385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC008_RS20390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC008_RS20400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DC008_RS20405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC008_RS20410	COG0839	Belongs to the complex I subunit 6 family
DC008_RS20415	COG0713	ATP synthesis coupled electron transport
DC008_RS20425	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DC008_RS20430	COG1007	ATP synthesis coupled electron transport
DC008_RS20435	COG0501	Belongs to the peptidase M48B family
DC008_RS20440	COG3304	Inner membrane component domain
DC008_RS20455	COG2261	transglycosylase associated protein
DC008_RS20460	COG1666	GTP binding
DC008_RS20505	COG1674	ftsk spoiiie
DC008_RS20540	COG2188	Transcriptional regulator
DC008_RS20560	COG0270	DNA (cytosine-5-)-methyltransferase activity
DC008_RS20610	COG0702	epimerase
DC008_RS20615	COG0402	S-adenosylhomocysteine deaminase activity
DC008_RS20630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DC008_RS20635	COG2030	dehydratase
DC008_RS20650	COG0477	Major facilitator Superfamily
DC008_RS20660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DC008_RS20665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DC008_RS20680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC008_RS20685	COG0436	Aminotransferase
DC008_RS20700	COG0250	Participates in transcription elongation, termination and antitermination
DC008_RS20705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DC008_RS20710	COG0081	regulation of translation
DC008_RS20720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DC008_RS20735	COG0085	RNA polymerase activity
DC008_RS20740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DC008_RS20750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DC008_RS20755	COG0049	tRNA binding
DC008_RS20760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DC008_RS20765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DC008_RS20775	COG0667	Aldo Keto reductase
DC008_RS20780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS20790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DC008_RS20795	COG0051	transcription antitermination factor activity, RNA binding
DC008_RS20800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DC008_RS20805	COG0088	Forms part of the polypeptide exit tunnel
DC008_RS20810	COG0089	rRNA binding
DC008_RS20815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DC008_RS20820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DC008_RS20825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DC008_RS20830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DC008_RS20835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DC008_RS20840	COG0255	Belongs to the universal ribosomal protein uL29 family
DC008_RS20845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DC008_RS20850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DC008_RS20855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DC008_RS20860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DC008_RS20865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DC008_RS20875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DC008_RS20880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DC008_RS20885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DC008_RS20890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DC008_RS20895	COG1841	ribosomal large subunit assembly
DC008_RS20900	COG0200	Binds to the 23S rRNA
DC008_RS20905	COG0201	protein transport
DC008_RS20910	COG0563	adenylate kinase activity
DC008_RS20920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DC008_RS20925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DC008_RS20930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DC008_RS20935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DC008_RS20940	COG0202	RNA polymerase activity
DC008_RS20945	COG0203	ribosomal protein L17
DC008_RS20950	COG0101	tRNA pseudouridine synthase activity
DC008_RS20960	COG2843	Capsule synthesis protein
DC008_RS20995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DC008_RS21000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DC008_RS21005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DC008_RS21020	COG1072	(Pantothenic acid kinase))
DC008_RS21025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DC008_RS21040	COG0736	holo-[acyl-carrier-protein] synthase activity
DC008_RS21050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DC008_RS21060	COG0802	atpase or kinase
DC008_RS21085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DC008_RS21110	COG4941	Belongs to the sigma-70 factor family
DC008_RS21120	COG0726	polysaccharide deacetylase
DC008_RS21125	COG0726	polysaccharide deacetylase
DC008_RS21130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DC008_RS21135	COG0459	protein refolding
DC008_RS21145	COG4221	oxidoreductase activity
DC008_RS21155	COG0583	DNA-binding transcription factor activity
DC008_RS21170	COG1595	DNA-templated transcription, initiation
DC008_RS21180	COG0516	GMP reductase activity
DC008_RS21190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DC008_RS21195	COG2815	serine threonine protein kinase
DC008_RS21195	COG0515	serine threonine protein kinase
DC008_RS21200	COG0515	serine threonine protein kinase
DC008_RS21200	COG2815	serine threonine protein kinase
DC008_RS21205	COG0515	serine threonine protein kinase
DC008_RS21210	COG2815	serine threonine protein kinase
DC008_RS21210	COG0515	serine threonine protein kinase
DC008_RS21215	COG0515	serine threonine protein kinase
DC008_RS21220	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS21245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DC008_RS21245	COG0519	Catalyzes the synthesis of GMP from XMP
DC008_RS21290	COG2197	response regulator
DC008_RS21335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS21335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS21350	COG0714	Associated with various cellular activities
DC008_RS21355	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DC008_RS21360	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DC008_RS21370	COG0045	succinate-CoA ligase (ADP-forming) activity
DC008_RS21400	COG0138	bifunctional purine biosynthesis protein purh
DC008_RS21415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DC008_RS21435	COG0039	L-malate dehydrogenase activity
DC008_RS21455	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS21465	COG0517	IMP dehydrogenase activity
DC008_RS21465	COG4175	Glycine betaine
DC008_RS21470	COG4176	ABC-type proline glycine betaine transport system permease component
DC008_RS21480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC008_RS21485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DC008_RS21510	COG0754	glutathionylspermidine amidase activity
DC008_RS21515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DC008_RS21540	COG0180	Tryptophanyl-tRNA synthetase
DC008_RS21560	COG0671	phosphoesterase, PA-phosphatase related
DC008_RS21575	COG1295	ribonuclease BN
DC008_RS21580	COG1686	Belongs to the peptidase S11 family
DC008_RS21590	COG1408	metallophosphoesterase
DC008_RS21600	COG2205	protein histidine kinase activity
DC008_RS21605	COG0745	RESPONSE REGULATOR receiver
DC008_RS21610	COG2409	Drug exporters of the RND superfamily
DC008_RS21660	COG1053	succinate dehydrogenase
DC008_RS21670	COG2009	succinate dehydrogenase
DC008_RS21680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DC008_RS21720	COG1595	DNA-templated transcription, initiation
DC008_RS21735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS21735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS21745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DC008_RS21755	COG1216	Glycosyl transferase, family 2
DC008_RS21770	COG2089	acid synthase
DC008_RS21780	COG2226	methyltransferase
DC008_RS21785	COG1473	amidohydrolase
DC008_RS21785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DC008_RS21790	COG1744	ABC transporter substrate-binding protein PnrA-like
DC008_RS21795	COG1744	ABC transporter substrate-binding protein PnrA-like
DC008_RS21800	COG3845	ABC transporter
DC008_RS21810	COG1079	Belongs to the binding-protein-dependent transport system permease family
DC008_RS21850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC008_RS21860	COG0583	DNA-binding transcription factor activity
DC008_RS21865	COG2814	Major facilitator Superfamily
DC008_RS21885	COG2205	protein histidine kinase activity
DC008_RS21890	COG0745	RESPONSE REGULATOR receiver
DC008_RS21895	COG1595	DNA-templated transcription, initiation
DC008_RS21915	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS21920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DC008_RS21930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DC008_RS21960	COG4770	biotin carboxylase activity
DC008_RS21970	COG0424	maF-like protein
DC008_RS21980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC008_RS21990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DC008_RS22000	COG1024	Enoyl-CoA hydratase
DC008_RS22010	COG2986	histidine ammonia-lyase
DC008_RS22040	COG1136	(ABC) transporter
DC008_RS22045	COG1404	Belongs to the peptidase S8 family
DC008_RS22055	COG1064	alcohol dehydrogenase
DC008_RS22070	COG3795	YCII-related domain
DC008_RS22075	COG4941	Belongs to the sigma-70 factor family
DC008_RS22085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DC008_RS22110	COG2255	four-way junction helicase activity
DC008_RS22115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DC008_RS22130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DC008_RS22140	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DC008_RS22150	COG2255	four-way junction helicase activity
DC008_RS22155	COG1331	Highly conserved protein containing a thioredoxin domain
DC008_RS22190	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DC008_RS22200	COG0436	Aminotransferase
DC008_RS22215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DC008_RS22230	COG1414	Transcriptional regulator
DC008_RS22235	COG0251	oxidation-reduction process
DC008_RS22240	COG2610	gluconate transmembrane transporter activity
DC008_RS22295	COG2894	cell division
DC008_RS22325	COG2197	response regulator
DC008_RS22360	COG2318	DinB family
DC008_RS22370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DC008_RS22375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DC008_RS22390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC008_RS22400	COG1136	(ABC) transporter
DC008_RS22420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DC008_RS22435	COG0114	fumarate hydratase activity
DC008_RS22440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DC008_RS22440	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DC008_RS22465	COG0778	Nitroreductase
DC008_RS22470	COG1722	exodeoxyribonuclease VII activity
DC008_RS22475	COG1570	exodeoxyribonuclease VII activity
DC008_RS22480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DC008_RS22495	COG0012	GTP binding
DC008_RS22515	COG0583	DNA-binding transcription factor activity
DC008_RS22520	COG0300	oxidoreductase activity
DC008_RS22570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DC008_RS22575	COG1053	succinate dehydrogenase
DC008_RS22595	COG1217	gtp-binding protein TYPA
DC008_RS22600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC008_RS22605	COG0747	negative chemotaxis
DC008_RS22615	COG0444	Belongs to the ABC transporter superfamily
DC008_RS22620	COG4608	Belongs to the ABC transporter superfamily
DC008_RS22625	COG4608	Belongs to the ABC transporter superfamily
DC008_RS22640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC008_RS22645	COG0601	transmembrane transport
DC008_RS22650	COG0747	negative chemotaxis
DC008_RS22660	COG0601	transmembrane transport
DC008_RS22665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC008_RS22675	COG4608	Belongs to the ABC transporter superfamily
DC008_RS22690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DC008_RS22710	COG4585	Histidine kinase
DC008_RS22715	COG2197	response regulator
DC008_RS22750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC008_RS22765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DC008_RS22775	COG0519	Catalyzes the synthesis of GMP from XMP
DC008_RS22780	COG1024	Enoyl-CoA hydratase
DC008_RS22795	COG1595	DNA-templated transcription, initiation
DC008_RS22810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DC008_RS22845	COG0598	Magnesium transport protein CorA
DC008_RS22855	COG2814	Major facilitator Superfamily
DC008_RS22870	COG2095	MarC family integral membrane protein
DC008_RS22880	COG1432	Conserved Protein
DC008_RS22890	COG0513	Belongs to the DEAD box helicase family
DC008_RS22995	COG0210	DNA helicase
DC008_RS23005	COG2816	NAD+ diphosphatase activity
DC008_RS23040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DC008_RS23090	COG3480	Lon protease (S16) C-terminal proteolytic domain
DC008_RS23100	COG1615	UPF0182 protein
DC008_RS23125	COG0753	catalase activity
DC008_RS23135	COG0483	inositol monophosphate 1-phosphatase activity
DC008_RS23150	COG2076	Multidrug Resistance protein
DC008_RS23160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DC008_RS23170	COG2135	peptidase activity
DC008_RS23180	COG1595	DNA-templated transcription, initiation
DC008_RS23185	COG5662	AntiSigma factor
DC008_RS23190	COG2199	diguanylate cyclase activity
DC008_RS23190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DC008_RS23205	COG0242	peptide deformylase activity
DC008_RS23215	COG2124	cytochrome p450
DC008_RS23235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DC008_RS23235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DC008_RS23255	COG2188	Transcriptional regulator
DC008_RS23260	COG2182	Extracellular solute-binding protein
DC008_RS23265	COG1175	transmembrane transport
DC008_RS23270	COG0395	ABC-type sugar transport system, permease component
DC008_RS23275	COG1472	Belongs to the glycosyl hydrolase 3 family
DC008_RS23280	COG0363	glucosamine-6-phosphate deaminase activity
DC008_RS23295	COG1597	lipid kinase activity
DC008_RS23305	COG1191	sigma factor activity
DC008_RS23325	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DC008_RS23335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DC008_RS23340	COG0142	geranyltranstransferase activity
DC008_RS23400	COG4106	trans-aconitate 2-methyltransferase activity
DC008_RS23405	COG1126	abc transporter atp-binding protein
DC008_RS23415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC008_RS23425	COG0281	malic enzyme
DC008_RS23430	COG0604	alcohol dehydrogenase
DC008_RS23440	COG0542	response to heat
DC008_RS23470	COG0567	Dehydrogenase, E1 component
DC008_RS23470	COG0508	dehydrogenase complex catalyzes the overall conversion of
DC008_RS23475	COG2205	protein histidine kinase activity
DC008_RS23480	COG0745	RESPONSE REGULATOR receiver
DC008_RS23490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DC008_RS23535	COG3152	Membrane
DC008_RS23550	COG1309	transcriptional regulator
DC008_RS23565	COG0768	penicillin binding
DC008_RS23580	COG2205	protein histidine kinase activity
DC008_RS23600	COG1793	dna ligase
DC008_RS23600	COG3285	dna ligase
DC008_RS23605	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DC008_RS23795	COG2188	Transcriptional regulator
DC008_RS23820	COG1674	ftsk spoiiie
DC008_RS23905	COG0019	diaminopimelate decarboxylase activity
DC008_RS23910	COG0460	homoserine dehydrogenase
DC008_RS23915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DC008_RS23920	COG0083	homoserine kinase activity
DC008_RS23940	COG0254	rRNA binding
DC008_RS23945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DC008_RS23950	COG2890	protein-(glutamine-N5) methyltransferase activity
DC008_RS23960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC008_RS23965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DC008_RS23970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DC008_RS23985	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DC008_RS23990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DC008_RS23995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DC008_RS24000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DC008_RS24005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DC008_RS24010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DC008_RS24015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DC008_RS24030	COG2197	response regulator
DC008_RS24035	COG4585	Histidine kinase
DC008_RS24060	COG1309	transcriptional regulator
DC008_RS24065	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC008_RS24080	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DC008_RS24115	COG1131	(ABC) transporter
DC008_RS24130	COG0346	lactoylglutathione lyase activity
DC008_RS24135	COG0183	Belongs to the thiolase family
DC008_RS24155	COG0745	RESPONSE REGULATOR receiver
DC008_RS24160	COG2205	protein histidine kinase activity
DC008_RS24230	COG2159	amidohydrolase
DC008_RS24240	COG2124	cytochrome p450
DC008_RS24245	COG2329	Antibiotic biosynthesis monooxygenase
DC008_RS24260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS24260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS24315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DC008_RS24320	COG0280	phosphate acetyltransferase
DC008_RS24320	COG0857	belongs to the CobB CobQ family
DC008_RS24325	COG0205	6-phosphofructokinase activity
DC008_RS24335	COG0395	ABC-type sugar transport system, permease component
DC008_RS24340	COG1175	transmembrane transport
DC008_RS24350	COG4565	transcriptional regulatory protein
DC008_RS24355	COG3290	protein histidine kinase activity
DC008_RS24360	COG1301	dicarboxylic acid transport
DC008_RS24380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DC008_RS24395	COG0366	Alpha amylase catalytic
DC008_RS24405	COG0058	SHG alpha-glucan phosphorylase activity
DC008_RS24430	COG1132	(ABC) transporter
DC008_RS24435	COG1132	(ABC) transporter
DC008_RS24440	COG1132	(ABC) transporter
DC008_RS24445	COG1132	(ABC) transporter
DC008_RS24460	COG4585	Histidine kinase
DC008_RS24465	COG2197	response regulator
DC008_RS24475	COG1376	ErfK ybiS ycfS ynhG family protein
DC008_RS24480	COG1376	ErfK ybiS ycfS ynhG family protein
DC008_RS24500	COG3757	hydrolase, family 25
DC008_RS24500	COG3409	Peptidoglycan-binding domain 1 protein
DC008_RS24505	COG1760	l-serine dehydratase
DC008_RS24510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DC008_RS24515	COG0509	glycine decarboxylation via glycine cleavage system
DC008_RS24520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DC008_RS24540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DC008_RS24545	COG0747	negative chemotaxis
DC008_RS24555	COG0444	Belongs to the ABC transporter superfamily
DC008_RS24560	COG4608	Belongs to the ABC transporter superfamily
DC008_RS24565	COG2860	membrane
DC008_RS24580	COG1309	transcriptional regulator
DC008_RS24600	COG0482	sulfurtransferase activity
DC008_RS24620	COG4221	oxidoreductase activity
DC008_RS24630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DC008_RS24640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DC008_RS24645	COG0154	amidase activity
DC008_RS24655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DC008_RS24660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DC008_RS24665	COG2409	Drug exporters of the RND superfamily
DC008_RS24670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC008_RS24685	COG1672	PFAM Archaeal ATPase
DC008_RS24685	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DC008_RS24695	COG2133	pyrroloquinoline quinone binding
DC008_RS24700	COG0667	Aldo Keto reductase
DC008_RS24710	COG5001	Diguanylate cyclase
DC008_RS24720	COG0440	acetolactate synthase activity
DC008_RS24725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DC008_RS24730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DC008_RS24735	COG0477	Major facilitator Superfamily
DC008_RS24745	COG2508	Transcriptional regulator
DC008_RS24750	COG0506	proline dehydrogenase activity
DC008_RS24755	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS24775	COG0473	3-isopropylmalate dehydrogenase activity
DC008_RS24780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DC008_RS24790	COG0831	urea catabolic process
DC008_RS24790	COG0832	Belongs to the urease beta subunit family
DC008_RS24795	COG0804	urea catabolic process
DC008_RS24800	COG2957	Belongs to the agmatine deiminase family
DC008_RS24815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DC008_RS24835	COG5492	domain, Protein
DC008_RS24840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DC008_RS24860	COG2018	Roadblock/LC7 domain
DC008_RS24880	COG2018	Roadblock/LC7 domain
DC008_RS24885	COG5002	protein histidine kinase activity
DC008_RS24895	COG0179	Fumarylacetoacetate (FAA) hydrolase
DC008_RS24900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DC008_RS24950	COG1414	Transcriptional regulator
DC008_RS24955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DC008_RS24960	COG0066	3-isopropylmalate dehydratase activity
DC008_RS24970	COG0776	regulation of translation
DC008_RS24980	COG1920	GTP binding
DC008_RS24990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DC008_RS24995	COG1181	Belongs to the D-alanine--D-alanine ligase family
DC008_RS25015	COG0351	phosphomethylpyrimidine kinase
DC008_RS25020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DC008_RS25025	COG1461	Dihydroxyacetone kinase
DC008_RS25035	COG0326	Molecular chaperone. Has ATPase activity
DC008_RS25045	COG0742	ribosomal rna small subunit methyltransferase
DC008_RS25050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DC008_RS25065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DC008_RS25070	COG0571	ribonuclease III activity
DC008_RS25075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DC008_RS25080	COG1733	regulation of RNA biosynthetic process
DC008_RS25105	COG2340	Cysteine-rich secretory protein family
DC008_RS25110	COG1254	Belongs to the acylphosphatase family
DC008_RS25125	COG1196	nuclear chromosome segregation
DC008_RS25130	COG0477	Major facilitator Superfamily
DC008_RS25165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DC008_RS25175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DC008_RS25185	COG0442	prolyl-tRNA aminoacylation
DC008_RS25195	COG0228	four-way junction DNA binding
DC008_RS25200	COG1837	Belongs to the UPF0109 family
DC008_RS25205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DC008_RS25210	COG0336	Belongs to the RNA methyltransferase TrmD family
DC008_RS25215	COG0335	large ribosomal subunit rRNA binding
DC008_RS25220	COG0681	Belongs to the peptidase S26 family
DC008_RS25230	COG0681	Belongs to the peptidase S26 family
DC008_RS25250	COG0792	nuclease activity
DC008_RS25265	COG1191	sigma factor activity
DC008_RS25275	COG4942	peptidase
DC008_RS25280	COG0052	Belongs to the universal ribosomal protein uS2 family
DC008_RS25285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DC008_RS25290	COG0528	UMP kinase activity
DC008_RS25295	COG0233	cytoplasmic translational termination
DC008_RS25300	COG0575	Belongs to the CDS family
DC008_RS25325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DC008_RS25335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DC008_RS25340	COG3842	ATPase activity
DC008_RS25375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DC008_RS25385	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS25390	COG2255	four-way junction helicase activity
DC008_RS25415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC008_RS25420	COG0584	glycerophosphoryl diester phosphodiesterase
DC008_RS25425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DC008_RS25450	COG3842	ATPase activity
DC008_RS25455	COG1176	ABC-type spermidine putrescine transport system, permease component I
DC008_RS25460	COG1177	transmembrane transport
DC008_RS25465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DC008_RS25500	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS25510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DC008_RS25515	COG0750	zinc metalloprotease
DC008_RS25520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DC008_RS25535	COG0442	prolyl-tRNA aminoacylation
DC008_RS25550	COG1595	DNA-templated transcription, initiation
DC008_RS25590	COG0779	Required for maturation of 30S ribosomal subunits
DC008_RS25605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DC008_RS25615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DC008_RS25620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DC008_RS25635	COG0455	bacterial-type flagellum organization
DC008_RS25665	COG1404	Belongs to the peptidase S8 family
DC008_RS25830	COG1674	ftsk spoiiie
DC008_RS25840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DC008_RS25845	COG1185	polyribonucleotide nucleotidyltransferase activity
DC008_RS25850	COG0612	Peptidase, M16
DC008_RS25855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DC008_RS25875	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DC008_RS25880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DC008_RS25885	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DC008_RS25920	COG2208	phosphoserine phosphatase activity
DC008_RS25920	COG2770	Histidine kinase
DC008_RS25930	COG4999	Histidine kinase
DC008_RS25930	COG3850	Histidine kinase
DC008_RS25930	COG3437	response regulator, receiver
DC008_RS25930	COG2205	protein histidine kinase activity
DC008_RS25940	COG1674	ftsk spoiiie
DC008_RS25950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DC008_RS25960	COG1546	Belongs to the CinA family
DC008_RS25960	COG1058	Belongs to the CinA family
DC008_RS25965	COG1396	sequence-specific DNA binding
DC008_RS25975	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS25980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DC008_RS25985	COG1201	RNA secondary structure unwinding
DC008_RS25990	COG1917	Cupin 2, conserved barrel domain protein
DC008_RS25990	COG2207	Transcriptional regulator
DC008_RS26025	COG5297	Belongs to the glycosyl hydrolase family 6
DC008_RS26055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DC008_RS26075	COG0765	amino acid transport
DC008_RS26080	COG0765	amino acid transport
DC008_RS26085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC008_RS26090	COG1126	abc transporter atp-binding protein
DC008_RS26095	COG0745	RESPONSE REGULATOR receiver
DC008_RS26100	COG2205	protein histidine kinase activity
DC008_RS26105	COG2358	TRAP transporter, solute receptor (TAXI family
DC008_RS26115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DC008_RS26135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DC008_RS26145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DC008_RS26150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DC008_RS26160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DC008_RS26190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DC008_RS26195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DC008_RS26200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DC008_RS26215	COG0588	phosphoglycerate mutase activity
DC008_RS26235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DC008_RS26250	COG0514	ATP-dependent DNA helicase (RecQ)
DC008_RS26270	COG2186	Transcriptional regulator
DC008_RS26275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DC008_RS26290	COG0187	DNA topoisomerase II activity
DC008_RS26300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DC008_RS26305	COG4565	transcriptional regulatory protein
DC008_RS26310	COG3290	protein histidine kinase activity
DC008_RS26325	COG0372	Belongs to the citrate synthase family
DC008_RS26345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DC008_RS26350	COG0612	Peptidase, M16
DC008_RS26365	COG1802	Transcriptional regulator
DC008_RS26370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DC008_RS26395	COG1435	thymidine kinase activity
DC008_RS26440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DC008_RS26450	COG0745	RESPONSE REGULATOR receiver
DC008_RS26455	COG2205	protein histidine kinase activity
DC008_RS26480	COG0756	dUTP diphosphatase activity
DC008_RS26520	COG0569	domain protein
DC008_RS26525	COG0531	amino acid
DC008_RS26530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DC008_RS26570	COG2936	dipeptidyl-peptidase activity
DC008_RS26600	COG0475	glutathione-regulated potassium exporter activity
DC008_RS26620	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DC008_RS26640	COG2192	nodulation
DC008_RS26665	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DC008_RS26685	COG1132	(ABC) transporter
DC008_RS26690	COG1132	(ABC) transporter
DC008_RS26755	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS26760	COG1799	cell septum assembly
DC008_RS26795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DC008_RS26815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DC008_RS26825	COG1024	Enoyl-CoA hydratase
DC008_RS26865	COG2208	phosphoserine phosphatase activity
DC008_RS26865	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS26865	COG2172	sigma factor antagonist activity
DC008_RS26890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DC008_RS26900	COG0137	argininosuccinate synthase activity
DC008_RS26905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DC008_RS26915	COG0714	Associated with various cellular activities
DC008_RS26930	COG1653	transport
DC008_RS26935	COG1175	transmembrane transport
DC008_RS26940	COG0395	ABC-type sugar transport system, permease component
DC008_RS26945	COG1940	carbohydrate kinase activity
DC008_RS26950	COG4213	ABC transporter substrate-binding protein
DC008_RS26960	COG4214	carbohydrate transport
DC008_RS26965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DC008_RS26970	COG0531	amino acid
DC008_RS26980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DC008_RS26990	COG1024	Enoyl-CoA hydratase
DC008_RS26990	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC008_RS26995	COG0183	Belongs to the thiolase family
DC008_RS27000	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DC008_RS27015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DC008_RS27030	COG0446	pyridine nucleotide-disulphide oxidoreductase
DC008_RS27040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DC008_RS27045	COG3253	May function as heme-dependent peroxidase
DC008_RS27065	COG3220	belongs to the UPF0276 family
DC008_RS27090	COG0330	HflC and HflK could
DC008_RS27120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DC008_RS27125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DC008_RS27140	COG1737	Transcriptional regulator
DC008_RS27145	COG4821	SIS domain
DC008_RS27175	COG0745	RESPONSE REGULATOR receiver
DC008_RS27180	COG2205	protein histidine kinase activity
DC008_RS27185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DC008_RS27190	COG5002	protein histidine kinase activity
DC008_RS27195	COG0745	RESPONSE REGULATOR receiver
DC008_RS27210	COG4106	trans-aconitate 2-methyltransferase activity
DC008_RS27220	COG1174	glycine betaine transport
DC008_RS27225	COG4176	ABC-type proline glycine betaine transport system permease component
DC008_RS27240	COG2018	Roadblock/LC7 domain
DC008_RS27245	COG5002	protein histidine kinase activity
DC008_RS27295	COG1404	Belongs to the peptidase S8 family
DC008_RS27325	COG0590	tRNA wobble adenosine to inosine editing
DC008_RS27330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DC008_RS27405	COG1175	transmembrane transport
DC008_RS27420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DC008_RS27445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DC008_RS27455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC008_RS27460	COG1116	anion transmembrane transporter activity
DC008_RS27480	COG0529	Catalyzes the synthesis of activated sulfate
DC008_RS27485	COG0175	sulfate reduction
DC008_RS27515	COG1960	acyl-CoA dehydrogenase activity
DC008_RS27525	COG0702	epimerase
DC008_RS27530	COG1917	Cupin 2, conserved barrel domain protein
DC008_RS27530	COG4977	sequence-specific DNA binding
DC008_RS27565	COG2040	homocysteine
DC008_RS27600	COG2197	response regulator
DC008_RS27605	COG4585	Histidine kinase
DC008_RS27610	COG1136	(ABC) transporter
DC008_RS27630	COG1940	carbohydrate kinase activity
DC008_RS27635	COG0277	FAD linked oxidase domain protein
DC008_RS27650	COG3291	Pkd domain containing protein
DC008_RS27650	COG4447	cellulose binding
DC008_RS27650	COG5520	Belongs to the glycosyl hydrolase 30 family
DC008_RS27655	COG1162	GTPase activity
DC008_RS27665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DC008_RS27705	COG1802	Transcriptional regulator
DC008_RS27730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DC008_RS27735	COG2252	PERMEase
DC008_RS27810	COG2124	cytochrome p450
DC008_RS27840	COG1280	lysine exporter protein (LysE YggA)
DC008_RS27855	COG2197	response regulator
DC008_RS27860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DC008_RS27865	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS27880	COG3960	tartronate-semialdehyde synthase activity
DC008_RS27890	COG2084	Dehydrogenase
DC008_RS27895	COG3622	Belongs to the hyi family
DC008_RS27915	COG2351	hydroxyisourate hydrolase activity
DC008_RS27930	COG2233	PERMEase
DC008_RS27935	COG0739	heme binding
DC008_RS27950	COG0406	alpha-ribazole phosphatase activity
DC008_RS27965	COG0436	Aminotransferase
DC008_RS27985	COG4264	IucA IucC family
DC008_RS28000	COG0475	glutathione-regulated potassium exporter activity
DC008_RS28015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DC008_RS28030	COG2197	response regulator
DC008_RS28035	COG4585	Histidine kinase
DC008_RS28045	COG1414	Transcriptional regulator
DC008_RS28050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DC008_RS28055	COG4266	Belongs to the allantoicase family
DC008_RS28075	COG2197	response regulator
DC008_RS28080	COG0673	inositol 2-dehydrogenase activity
DC008_RS28085	COG2188	Transcriptional regulator
DC008_RS28090	COG1940	carbohydrate kinase activity
DC008_RS28100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DC008_RS28115	COG0574	Belongs to the PEP-utilizing enzyme family
DC008_RS28115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DC008_RS28140	COG0513	Belongs to the DEAD box helicase family
DC008_RS28145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DC008_RS28150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC008_RS28185	COG0405	Gamma-glutamyltransferase
DC008_RS28190	COG0542	response to heat
DC008_RS28215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DC008_RS28230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DC008_RS28240	COG1953	Uracil, thiamine, allantoin
DC008_RS28255	COG3851	Histidine kinase
DC008_RS28260	COG2197	response regulator
DC008_RS28290	COG0483	inositol monophosphate 1-phosphatase activity
DC008_RS28315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DC008_RS28320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DC008_RS28340	COG1929	Belongs to the glycerate kinase type-1 family
DC008_RS28350	COG0688	phosphatidylethanolamine metabolic process
DC008_RS28355	COG1960	acyl-CoA dehydrogenase activity
DC008_RS28370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS28370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DC008_RS28375	COG0604	alcohol dehydrogenase
DC008_RS28385	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC008_RS28425	COG2172	sigma factor antagonist activity
DC008_RS28425	COG2208	phosphoserine phosphatase activity
DC008_RS28425	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS28430	COG2226	methyltransferase
DC008_RS28450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DC008_RS28460	COG1619	proteins homologs of microcin C7 resistance protein MccF
DC008_RS28495	COG3285	dna ligase
DC008_RS28495	COG1793	dna ligase
DC008_RS28555	COG1597	lipid kinase activity
DC008_RS28560	COG0406	alpha-ribazole phosphatase activity
DC008_RS28565	COG0488	(ABC) transporter
DC008_RS28580	COG0693	protein deglycase activity
DC008_RS28605	COG0028	Belongs to the TPP enzyme family
DC008_RS28635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DC008_RS28665	COG0443	Heat shock 70 kDa protein
DC008_RS28675	COG1140	nitrate reductase beta subunit
DC008_RS28705	COG2154	pterin-4-alpha-carbinolamine dehydratase
DC008_RS28710	COG2226	methyltransferase
DC008_RS28725	COG0656	L-ascorbic acid biosynthetic process
DC008_RS28735	COG0583	DNA-binding transcription factor activity
DC008_RS28750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DC008_RS28765	COG3383	formate dehydrogenase (NAD+) activity
DC008_RS28770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DC008_RS28780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC008_RS28790	COG1940	carbohydrate kinase activity
DC008_RS28795	COG1129	ABC transporter
DC008_RS28800	COG1172	Belongs to the binding-protein-dependent transport system permease family
DC008_RS28810	COG0673	inositol 2-dehydrogenase activity
DC008_RS28830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DC008_RS28865	COG2223	nitrite transmembrane transporter activity
DC008_RS28875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC008_RS28885	COG0045	succinate-CoA ligase (ADP-forming) activity
DC008_RS28895	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS28925	COG0477	Major facilitator Superfamily
DC008_RS28930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DC008_RS28935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DC008_RS28945	COG2182	Extracellular solute-binding protein
DC008_RS28950	COG1175	transmembrane transport
DC008_RS28955	COG0395	ABC-type sugar transport system, permease component
DC008_RS28960	COG2723	6-phospho-beta-galactosidase activity
DC008_RS29010	COG1012	belongs to the aldehyde dehydrogenase family
DC008_RS29020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DC008_RS29045	COG0438	transferase activity, transferring glycosyl groups
DC008_RS29065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DC008_RS29095	COG0346	lactoylglutathione lyase activity
DC008_RS29105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DC008_RS29110	COG0166	Belongs to the GPI family
DC008_RS29125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DC008_RS29150	COG1414	Transcriptional regulator
DC008_RS29155	COG3250	beta-galactosidase activity
DC008_RS29160	COG3833	ABC-type maltose transport systems, permease component
DC008_RS29165	COG1175	transmembrane transport
DC008_RS29175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS29185	COG1486	melibiose metabolic process
DC008_RS29205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DC008_RS29255	COG3938	Belongs to the proline racemase family
DC008_RS29275	COG1175	transmembrane transport
DC008_RS29280	COG0395	ABC-type sugar transport system, permease component
DC008_RS29285	COG0366	Alpha amylase catalytic
DC008_RS29300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC008_RS29305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC008_RS29310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DC008_RS29315	COG1414	Transcriptional regulator
DC008_RS29335	COG3511	phospholipase C
DC008_RS29370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC008_RS29375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DC008_RS29380	COG3485	protocatechuate 3,4-dioxygenase
DC008_RS29385	COG3485	protocatechuate 3,4-dioxygenase
DC008_RS29400	COG1846	Transcriptional regulator
DC008_RS29415	COG1793	dna ligase
DC008_RS29460	COG1834	amidinotransferase
DC008_RS29465	COG0488	(ABC) transporter
DC008_RS29485	COG1515	deoxyribonuclease V activity
DC008_RS29490	COG3268	Saccharopine dehydrogenase
DC008_RS29500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC008_RS29505	COG1960	acyl-CoA dehydrogenase activity
DC008_RS29510	COG0183	Belongs to the thiolase family
DC008_RS29515	COG1250	3-hydroxyacyl-CoA dehydrogenase
DC008_RS29515	COG1024	Enoyl-CoA hydratase
DC008_RS29525	COG1113	amino acid transport
DC008_RS29530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS29540	COG2936	dipeptidyl-peptidase activity
DC008_RS29550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DC008_RS29560	COG0488	(ABC) transporter
DC008_RS29565	COG2183	response to ionizing radiation
DC008_RS29585	COG1024	Enoyl-CoA hydratase
DC008_RS29595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DC008_RS29640	COG1134	teichoic acid transport
DC008_RS29645	COG1562	ergosterol biosynthetic process
DC008_RS29655	COG1233	COG1233 Phytoene dehydrogenase and related
DC008_RS29665	COG1657	PFAM Prenyltransferase squalene oxidase
DC008_RS29680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DC008_RS29685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DC008_RS29705	COG2365	Tyrosine phosphatase family
DC008_RS29715	COG2755	lipolytic protein G-D-S-L family
DC008_RS29735	COG3619	membrane
DC008_RS29775	COG0583	DNA-binding transcription factor activity
DC008_RS29780	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS29790	COG1063	alcohol dehydrogenase
DC008_RS29795	COG0156	8-amino-7-oxononanoate synthase activity
DC008_RS29800	COG0583	DNA-binding transcription factor activity
DC008_RS29840	COG1309	transcriptional regulator
DC008_RS29845	COG3387	PFAM Glycoside hydrolase 15-related
DC008_RS29850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DC008_RS29865	COG0174	glutamine synthetase
DC008_RS29895	COG0183	Belongs to the thiolase family
DC008_RS29935	COG0494	nUDIX hydrolase
DC008_RS29955	COG3511	phospholipase C
DC008_RS30005	COG2188	Transcriptional regulator
DC008_RS30015	COG3962	Belongs to the TPP enzyme family
DC008_RS30020	COG3718	enzyme involved in inositol metabolism
DC008_RS30030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DC008_RS30055	COG0673	inositol 2-dehydrogenase activity
DC008_RS30060	COG0673	inositol 2-dehydrogenase activity
DC008_RS30065	COG0673	inositol 2-dehydrogenase activity
DC008_RS30070	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS30085	COG3548	integral membrane protein
DC008_RS30090	COG0673	inositol 2-dehydrogenase activity
DC008_RS30095	COG1609	Transcriptional regulator
DC008_RS30105	COG2186	Transcriptional regulator
DC008_RS30110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DC008_RS30115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DC008_RS30145	COG1414	Transcriptional regulator
DC008_RS30150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DC008_RS30155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DC008_RS30160	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DC008_RS30175	COG0765	amino acid transport
DC008_RS30180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS30190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DC008_RS30205	COG0431	NADPH-dependent FMN reductase
DC008_RS30235	COG0765	amino acid transport
DC008_RS30240	COG1126	abc transporter atp-binding protein
DC008_RS30250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS30255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS30295	COG2838	Isocitrate dehydrogenase
DC008_RS30305	COG0668	transmembrane transport
DC008_RS30310	COG1024	Enoyl-CoA hydratase
DC008_RS30325	COG1874	Beta-galactosidase
DC008_RS30325	COG0366	Alpha amylase catalytic
DC008_RS30335	COG4221	oxidoreductase activity
DC008_RS30350	COG3693	PFAM glycoside hydrolase, family 10
DC008_RS30380	COG0583	DNA-binding transcription factor activity
DC008_RS30390	COG0656	L-ascorbic acid biosynthetic process
DC008_RS30425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DC008_RS30440	COG2267	carboxylic ester hydrolase activity
DC008_RS30445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DC008_RS30465	COG0297	glycogen (starch) synthase activity
DC008_RS30470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DC008_RS30515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DC008_RS30530	COG1175	transmembrane transport
DC008_RS30535	COG0395	ABC-type sugar transport system, permease component
DC008_RS30565	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS30595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DC008_RS30650	COG0726	polysaccharide deacetylase
DC008_RS30695	COG0583	DNA-binding transcription factor activity
DC008_RS30705	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS30710	COG2197	response regulator
DC008_RS30720	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS30725	COG0583	DNA-binding transcription factor activity
DC008_RS30735	COG1053	succinate dehydrogenase
DC008_RS30740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DC008_RS30800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS30810	COG3360	Dodecin
DC008_RS30815	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DC008_RS30820	COG0121	glutamine amidotransferase
DC008_RS30825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DC008_RS30850	COG1595	DNA-templated transcription, initiation
DC008_RS30895	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DC008_RS30910	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS30930	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS30945	COG4948	Mandelate Racemase Muconate Lactonizing
DC008_RS30970	COG4221	oxidoreductase activity
DC008_RS30975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DC008_RS31010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DC008_RS31020	COG0242	peptide deformylase activity
DC008_RS31070	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DC008_RS31080	COG1063	alcohol dehydrogenase
DC008_RS31105	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DC008_RS31105	COG2308	Evidence 4 Homologs of previously reported genes of
DC008_RS31110	COG0367	asparagine synthase
DC008_RS31135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC008_RS31145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DC008_RS31160	COG2124	cytochrome p450
DC008_RS31165	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS31185	COG2135	peptidase activity
DC008_RS31200	COG0604	alcohol dehydrogenase
DC008_RS31215	COG0542	response to heat
DC008_RS31225	COG1556	Lactate utilization protein
DC008_RS31230	COG1139	Iron-sulfur cluster binding protein
DC008_RS31235	COG0247	lactate metabolic process
DC008_RS31240	COG1070	Carbohydrate kinase
DC008_RS31245	COG3347	Dehydrogenase
DC008_RS31245	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS31250	COG4952	isomerase
DC008_RS31255	COG1129	ABC transporter
DC008_RS31260	COG1172	Belongs to the binding-protein-dependent transport system permease family
DC008_RS31265	COG1172	Belongs to the binding-protein-dependent transport system permease family
DC008_RS31270	COG1879	ABC-type sugar transport system periplasmic component
DC008_RS31280	COG1609	Transcriptional regulator
DC008_RS31295	COG1357	PFAM Pentapeptide repeats (8 copies)
DC008_RS31305	COG1309	transcriptional regulator
DC008_RS31315	COG2706	6-phosphogluconolactonase activity
DC008_RS31350	COG1796	DNA polymerase
DC008_RS31350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DC008_RS31375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DC008_RS31380	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS31405	COG0435	Glutathione S-transferase
DC008_RS31425	COG2124	cytochrome p450
DC008_RS31440	COG0667	Aldo Keto reductase
DC008_RS31455	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS31455	COG2172	sigma factor antagonist activity
DC008_RS31455	COG2208	phosphoserine phosphatase activity
DC008_RS31475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DC008_RS31490	COG0248	Ppx GppA phosphatase
DC008_RS31550	COG1215	transferase activity, transferring glycosyl groups
DC008_RS31560	COG3608	succinylglutamate desuccinylase aspartoacylase
DC008_RS31560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DC008_RS31595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DC008_RS31610	COG1959	2 iron, 2 sulfur cluster binding
DC008_RS31610	COG1295	ribonuclease BN
DC008_RS31615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DC008_RS31630	COG1132	(ABC) transporter
DC008_RS31640	COG1937	Protein conserved in bacteria
DC008_RS31665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DC008_RS31670	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS31680	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS31685	COG1376	ErfK ybiS ycfS ynhG family protein
DC008_RS31695	COG2182	Extracellular solute-binding protein
DC008_RS31700	COG0395	ABC-type sugar transport system, permease component
DC008_RS31705	COG1175	transmembrane transport
DC008_RS31710	COG1940	carbohydrate kinase activity
DC008_RS31710	COG1846	Transcriptional regulator
DC008_RS31735	COG1309	transcriptional regulator
DC008_RS31760	COG0328	RNA-DNA hybrid ribonuclease activity
DC008_RS31765	COG2304	oxidoreductase activity
DC008_RS31780	COG0667	Aldo Keto reductase
DC008_RS31790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DC008_RS31800	COG0515	serine threonine protein kinase
DC008_RS31800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DC008_RS31805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DC008_RS31830	COG1846	Transcriptional regulator
DC008_RS31830	COG1940	carbohydrate kinase activity
DC008_RS31835	COG3345	alpha-galactosidase
DC008_RS31850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DC008_RS31850	COG1672	PFAM Archaeal ATPase
DC008_RS31880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DC008_RS31905	COG3189	MarR family transcriptional regulator
DC008_RS31920	COG5002	protein histidine kinase activity
DC008_RS31970	COG1252	NADH dehydrogenase
DC008_RS31995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DC008_RS32000	COG3281	Trehalose synthase
DC008_RS32010	COG0366	Alpha amylase catalytic
DC008_RS32050	COG0181	hydroxymethylbilane synthase activity
DC008_RS32085	COG0596	Alpha beta hydrolase
DC008_RS32115	COG0009	L-threonylcarbamoyladenylate synthase
DC008_RS32135	COG3845	ABC transporter
DC008_RS32160	COG0318	PFAM AMP-dependent synthetase and ligase
DC008_RS32170	COG3320	Male sterility
DC008_RS32170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DC008_RS32180	COG2267	carboxylic ester hydrolase activity
DC008_RS32190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DC008_RS32205	COG0277	FAD linked oxidase domain protein
DC008_RS32210	COG1597	lipid kinase activity
DC008_RS32255	COG0725	ABC transporter, periplasmic molybdate-binding protein
DC008_RS32290	COG1191	sigma factor activity
DC008_RS32315	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS32320	COG1366	Belongs to the anti-sigma-factor antagonist family
DC008_RS32325	COG2172	sigma factor antagonist activity
DC008_RS32345	COG2197	response regulator
DC008_RS32390	COG0477	Major facilitator Superfamily
DC008_RS32395	COG1120	ATPase activity
DC008_RS32420	COG1335	isochorismatase
DC008_RS32425	COG1982	Orn Lys Arg decarboxylase major
DC008_RS32440	COG2890	protein-(glutamine-N5) methyltransferase activity
DC008_RS32445	COG0655	NAD(P)H dehydrogenase (quinone) activity
DC008_RS32450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DC008_RS32450	COG0723	plastoquinol--plastocyanin reductase activity
DC008_RS32475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DC008_RS32490	COG0531	amino acid
DC008_RS32510	COG3387	PFAM Glycoside hydrolase 15-related
DC008_RS32580	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS32600	COG1017	nitric oxide dioxygenase activity
DC008_RS32600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DC008_RS32605	COG1846	Transcriptional regulator
DC008_RS32610	COG2409	Drug exporters of the RND superfamily
DC008_RS32650	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS32695	COG2508	Transcriptional regulator
DC008_RS32705	COG0410	ABC transporter
DC008_RS32710	COG0411	ABC transporter
DC008_RS32745	COG0142	geranyltranstransferase activity
DC008_RS32765	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DC008_RS32770	COG2226	methyltransferase
DC008_RS32785	COG1191	sigma factor activity
DC008_RS32840	COG2770	Histidine kinase
DC008_RS32840	COG2208	phosphoserine phosphatase activity
DC008_RS32845	COG0697	spore germination
DC008_RS32850	COG1846	Transcriptional regulator
DC008_RS32855	COG0783	Belongs to the Dps family
DC008_RS32865	COG2205	protein histidine kinase activity
DC008_RS32865	COG5002	protein histidine kinase activity
DC008_RS32865	COG0784	Response regulator, receiver
DC008_RS32870	COG0395	ABC-type sugar transport system, permease component
DC008_RS32875	COG1175	transmembrane transport
DC008_RS32880	COG1653	transport
DC008_RS32890	COG2186	Transcriptional regulator
DC008_RS32950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DC008_RS32950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DC008_RS32960	COG2197	response regulator
DC008_RS32965	COG4585	Histidine kinase
DC008_RS33005	COG1278	Cold shock
DC008_RS33010	COG0513	Belongs to the DEAD box helicase family
DC008_RS33040	COG0589	response to stress
DC008_RS33050	COG3387	PFAM Glycoside hydrolase 15-related
DC008_RS33055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DC008_RS33060	COG3265	gluconokinase activity
DC008_RS33075	COG2226	methyltransferase
DC008_RS33080	COG0673	inositol 2-dehydrogenase activity
DC008_RS33130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DC008_RS33225	COG0395	ABC-type sugar transport system, permease component
DC008_RS33250	COG2130	NADP-dependent
DC008_RS33255	COG2814	Major facilitator Superfamily
DC008_RS33270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DC008_RS33295	COG2814	Major facilitator Superfamily
DC008_RS33335	COG0477	Major facilitator Superfamily
DC008_RS33345	COG0574	Belongs to the PEP-utilizing enzyme family
DC008_RS33345	COG3848	Pyruvate phosphate dikinase
DC008_RS33390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DC008_RS33390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DC008_RS33400	COG3469	chitinase activity
DC008_RS33430	COG0045	succinate-CoA ligase (ADP-forming) activity
DC008_RS33430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DC008_RS33430	COG1042	CoA-binding domain protein
DC008_RS33435	COG0517	IMP dehydrogenase activity
DC008_RS33435	COG0516	GMP reductase activity
DC008_RS33455	COG0667	Aldo Keto reductase
DC008_RS33460	COG0583	DNA-binding transcription factor activity
DC008_RS33490	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS33500	COG4977	sequence-specific DNA binding
DC008_RS33510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DC008_RS33535	COG1175	transmembrane transport
DC008_RS33555	COG0395	ABC-type sugar transport system, permease component
DC008_RS33580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DC008_RS33610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DC008_RS33640	COG4585	Histidine kinase
DC008_RS33655	COG1136	(ABC) transporter
DC008_RS33700	COG2318	DinB family
DC008_RS33715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DC008_RS33765	COG0284	orotidine-5'-phosphate decarboxylase activity
DC008_RS33790	COG0028	Belongs to the TPP enzyme family
DC008_RS33795	COG0076	glutamate decarboxylase activity
DC008_RS33840	COG2249	NAD(P)H dehydrogenase (quinone) activity
DC008_RS33850	COG0517	IMP dehydrogenase activity
DC008_RS33850	COG0516	GMP reductase activity
DC008_RS33860	COG4106	trans-aconitate 2-methyltransferase activity
DC008_RS33885	COG0477	Major facilitator Superfamily
DC008_RS33970	COG0436	Aminotransferase
DC008_RS33995	COG0789	Transcriptional regulator
DC008_RS34025	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DC008_RS34040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DC008_RS34045	COG1595	DNA-templated transcription, initiation
DC008_RS34075	COG1280	lysine exporter protein (LysE YggA)
DC008_RS34080	COG1252	NADH dehydrogenase
DC008_RS34085	COG1595	DNA-templated transcription, initiation
DC008_RS34105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DC008_RS34185	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DC008_RS34215	COG1846	Transcriptional regulator
DC008_RS34220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DC008_RS34235	COG0402	S-adenosylhomocysteine deaminase activity
DC008_RS34270	COG0667	Aldo Keto reductase
DC008_RS34280	COG0583	DNA-binding transcription factor activity
DC008_RS34285	COG2239	Acts as a magnesium transporter
DC008_RS34290	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS34305	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS34335	COG3835	regulator
DC008_RS34340	COG0443	Heat shock 70 kDa protein
DC008_RS34345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DC008_RS34360	COG0542	response to heat
DC008_RS34375	COG3634	alkyl hydroperoxide reductase activity
DC008_RS34380	COG0071	Belongs to the small heat shock protein (HSP20) family
DC008_RS34395	COG2770	Histidine kinase
DC008_RS34395	COG2208	phosphoserine phosphatase activity
DC008_RS34425	COG0523	cobalamin synthesis protein
DC008_RS34435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DC008_RS34440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DC008_RS34445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DC008_RS34450	COG0254	rRNA binding
DC008_RS34460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DC008_RS34475	COG0701	Predicted permease
DC008_RS34480	COG1121	(ABC) transporter
DC008_RS34485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DC008_RS34510	COG2326	polyphosphate kinase activity
DC008_RS34540	COG0464	growth
DC008_RS34545	COG1404	Belongs to the peptidase S8 family
DC008_RS34550	COG1674	ftsk spoiiie
DC008_RS34600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DC008_RS34640	COG2124	cytochrome p450
DC008_RS34655	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DC008_RS34685	COG1737	Transcriptional regulator
DC008_RS34720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DC008_RS34735	COG0492	ferredoxin-NADP+ reductase activity
DC008_RS34740	COG0475	glutathione-regulated potassium exporter activity
DC008_RS34740	COG0589	response to stress
DC008_RS34745	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DC008_RS34790	COG1309	transcriptional regulator
DC008_RS34805	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS34820	COG0667	Aldo Keto reductase
DC008_RS34845	COG1063	alcohol dehydrogenase
DC008_RS34850	COG1028	Short-chain dehydrogenase reductase Sdr
DC008_RS34860	COG1175	transmembrane transport
DC008_RS34865	COG0395	ABC-type sugar transport system, permease component
DC008_RS34870	COG4948	Mandelate Racemase Muconate Lactonizing
DC008_RS34885	COG2186	Transcriptional regulator
DC008_RS34910	COG0584	glycerophosphoryl diester phosphodiesterase
DC008_RS34915	COG1115	amino acid carrier protein
DC008_RS34915	COG1115	amino acid carrier protein
DC008_RS34925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DC008_RS34955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DC008_RS34960	COG0569	domain protein
DC008_RS35040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DC008_RS35075	COG2226	methyltransferase