locus-tag	class	description
ASR50_RS00025	COG3293	Transposase
ASR50_RS00035	COG0419	ATPase involved in DNA repair
ASR50_RS00040	COG0420	3'-5' exonuclease activity
ASR50_RS00100	COG3293	Transposase
ASR50_RS00430	COG0791	NLP P60 protein
ASR50_RS00430	COG3883	PFAM NLP P60 protein
ASR50_RS00530	COG3293	Transposase
ASR50_RS00535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASR50_RS00815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASR50_RS00820	COG1316	TRANSCRIPTIONal
ASR50_RS00825	COG0640	Transcriptional regulator
ASR50_RS00830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASR50_RS00835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASR50_RS00855	COG4974	Belongs to the 'phage' integrase family
ASR50_RS00900	COG4221	oxidoreductase activity
ASR50_RS00935	COG0583	DNA-binding transcription factor activity
ASR50_RS01070	COG2801	Transposase and inactivated derivatives
ASR50_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS01080	COG0477	Major facilitator Superfamily
ASR50_RS01085	COG0778	Nitroreductase
ASR50_RS01095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASR50_RS01100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASR50_RS01105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASR50_RS01110	COG4106	trans-aconitate 2-methyltransferase activity
ASR50_RS01125	COG0596	Alpha beta hydrolase
ASR50_RS01135	COG2197	response regulator
ASR50_RS01140	COG4585	Histidine kinase
ASR50_RS01160	COG0604	alcohol dehydrogenase
ASR50_RS01160	COG3321	synthase
ASR50_RS01170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASR50_RS01175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASR50_RS01180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASR50_RS01200	COG0604	alcohol dehydrogenase
ASR50_RS01200	COG3321	synthase
ASR50_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS01225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASR50_RS01230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASR50_RS01235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS01245	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS01250	COG2130	NADP-dependent
ASR50_RS01315	COG2801	Transposase and inactivated derivatives
ASR50_RS01325	COG4221	oxidoreductase activity
ASR50_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS01345	COG3631	Ketosteroid isomerase-related protein
ASR50_RS01370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASR50_RS01375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASR50_RS01380	COG0076	glutamate decarboxylase activity
ASR50_RS01385	COG0531	amino acid
ASR50_RS01420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASR50_RS01435	COG4221	oxidoreductase activity
ASR50_RS01440	COG3844	kynureninase activity
ASR50_RS01450	COG3483	tryptophan 2,3-dioxygenase activity
ASR50_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS01460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASR50_RS01465	COG2151	metal-sulfur cluster biosynthetic enzyme
ASR50_RS01470	COG3396	Phenylacetate-CoA oxygenase
ASR50_RS01480	COG3396	Phenylacetate-CoA oxygenase
ASR50_RS01485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASR50_RS01505	COG0604	alcohol dehydrogenase
ASR50_RS01515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASR50_RS01525	COG1595	DNA-templated transcription, initiation
ASR50_RS01550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ASR50_RS01600	COG0583	DNA-binding transcription factor activity
ASR50_RS01610	COG2249	NAD(P)H dehydrogenase (quinone) activity
ASR50_RS01675	COG1674	ftsk spoiiie
ASR50_RS01680	COG1404	Belongs to the peptidase S8 family
ASR50_RS01685	COG0464	growth
ASR50_RS01720	COG4948	Mandelate Racemase Muconate Lactonizing
ASR50_RS01725	COG1802	Transcriptional regulator
ASR50_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS01740	COG0640	Transcriptional regulator
ASR50_RS01745	COG2217	Heavy metal translocating P-type atpase
ASR50_RS01770	COG0523	cobalamin synthesis protein
ASR50_RS01780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASR50_RS01785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASR50_RS01790	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASR50_RS01795	COG0254	rRNA binding
ASR50_RS01805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASR50_RS01815	COG0701	Predicted permease
ASR50_RS01835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASR50_RS01840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASR50_RS01855	COG1132	(ABC) transporter
ASR50_RS01880	COG1120	ATPase activity
ASR50_RS01885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASR50_RS01890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASR50_RS01925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASR50_RS01930	COG1120	ATPase activity
ASR50_RS01940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASR50_RS01955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ASR50_RS01960	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ASR50_RS01965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ASR50_RS02010	COG1937	Protein conserved in bacteria
ASR50_RS02015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASR50_RS02025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASR50_RS02080	COG0583	DNA-binding transcription factor activity
ASR50_RS02100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASR50_RS02125	COG4106	trans-aconitate 2-methyltransferase activity
ASR50_RS02135	COG0477	Major facilitator Superfamily
ASR50_RS02145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASR50_RS02200	COG0574	Belongs to the PEP-utilizing enzyme family
ASR50_RS02200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASR50_RS02210	COG0739	heme binding
ASR50_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS02240	COG0514	ATP-dependent DNA helicase (RecQ)
ASR50_RS02255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASR50_RS02270	COG2814	Major facilitator Superfamily
ASR50_RS02285	COG0477	Major facilitator Superfamily
ASR50_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS02350	COG1309	transcriptional regulator
ASR50_RS02355	COG2755	lipolytic protein G-D-S-L family
ASR50_RS02430	COG4326	sporulation control protein
ASR50_RS02435	COG2258	MOSC domain
ASR50_RS02440	COG0028	Belongs to the TPP enzyme family
ASR50_RS02445	COG4948	Mandelate Racemase Muconate Lactonizing
ASR50_RS02450	COG3387	PFAM Glycoside hydrolase 15-related
ASR50_RS02460	COG0300	oxidoreductase activity
ASR50_RS02465	COG2318	DinB family
ASR50_RS02470	COG0531	amino acid
ASR50_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS02535	COG1309	transcriptional regulator
ASR50_RS02595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ASR50_RS02620	COG1309	transcriptional regulator
ASR50_RS02640	COG0702	epimerase
ASR50_RS02645	COG0142	geranyltranstransferase activity
ASR50_RS02650	COG0783	Belongs to the Dps family
ASR50_RS02670	COG0657	acetylesterase activity
ASR50_RS02680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ASR50_RS02690	COG1366	Belongs to the anti-sigma-factor antagonist family
ASR50_RS02695	COG2267	carboxylic ester hydrolase activity
ASR50_RS02710	COG1755	Isoprenylcysteine carboxyl methyltransferase
ASR50_RS02730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASR50_RS02745	COG0300	oxidoreductase activity
ASR50_RS02780	COG0395	ABC-type sugar transport system, permease component
ASR50_RS02785	COG1175	transmembrane transport
ASR50_RS02825	COG1959	2 iron, 2 sulfur cluster binding
ASR50_RS02860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASR50_RS02865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASR50_RS02870	COG0254	rRNA binding
ASR50_RS02875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASR50_RS02945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ASR50_RS02955	COG0644	oxidoreductase
ASR50_RS02965	COG0667	Aldo Keto reductase
ASR50_RS03005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ASR50_RS03010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ASR50_RS03015	COG2186	Transcriptional regulator
ASR50_RS03020	COG0129	dihydroxy-acid dehydratase activity
ASR50_RS03030	COG1472	Belongs to the glycosyl hydrolase 3 family
ASR50_RS03040	COG1175	transmembrane transport
ASR50_RS03045	COG1653	transport
ASR50_RS03070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ASR50_RS03095	COG0490	domain, Protein
ASR50_RS03095	COG2985	domain, Protein
ASR50_RS03115	COG3383	formate dehydrogenase (NAD+) activity
ASR50_RS03120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASR50_RS03130	COG0589	response to stress
ASR50_RS03140	COG4109	DRTGG domain
ASR50_RS03160	COG1063	alcohol dehydrogenase
ASR50_RS03170	COG0569	domain protein
ASR50_RS03175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASR50_RS03230	COG0477	Major facilitator Superfamily
ASR50_RS03250	COG1879	ABC-type sugar transport system periplasmic component
ASR50_RS03255	COG1129	ABC transporter
ASR50_RS03260	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASR50_RS03265	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASR50_RS03280	COG4585	Histidine kinase
ASR50_RS03285	COG2197	response regulator
ASR50_RS03290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASR50_RS03300	COG0405	Gamma-glutamyltransferase
ASR50_RS03305	COG3619	membrane
ASR50_RS03310	COG2814	Major facilitator Superfamily
ASR50_RS03330	COG2274	protein secretion by the type I secretion system
ASR50_RS03355	COG1309	transcriptional regulator
ASR50_RS03360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ASR50_RS03385	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ASR50_RS03400	COG1733	regulation of RNA biosynthetic process
ASR50_RS03410	COG2259	Doxx family
ASR50_RS03420	COG0542	response to heat
ASR50_RS03440	COG0577	efflux transmembrane transporter activity
ASR50_RS03440	COG1136	(ABC) transporter
ASR50_RS03465	COG1819	glycosyl
ASR50_RS03470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASR50_RS03475	COG1595	DNA-templated transcription, initiation
ASR50_RS03485	COG1053	succinate dehydrogenase
ASR50_RS03515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASR50_RS03515	COG1263	PTS System
ASR50_RS03520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASR50_RS03525	COG1051	belongs to the nudix hydrolase family
ASR50_RS03545	COG1404	Belongs to the peptidase S8 family
ASR50_RS03580	COG1024	Enoyl-CoA hydratase
ASR50_RS03600	COG1357	PFAM Pentapeptide repeats (8 copies)
ASR50_RS03640	COG3766	membrane
ASR50_RS03670	COG1597	lipid kinase activity
ASR50_RS03675	COG0277	FAD linked oxidase domain protein
ASR50_RS03695	COG1082	Xylose isomerase domain protein TIM barrel
ASR50_RS03740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASR50_RS03745	COG0395	ABC-type sugar transport system, permease component
ASR50_RS03750	COG1175	transmembrane transport
ASR50_RS03770	COG0596	Alpha beta hydrolase
ASR50_RS03805	COG2208	phosphoserine phosphatase activity
ASR50_RS03815	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ASR50_RS03820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASR50_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS03895	COG2409	Drug exporters of the RND superfamily
ASR50_RS03905	COG0456	acetyltransferase
ASR50_RS03910	COG1295	ribonuclease BN
ASR50_RS03920	COG2226	methyltransferase
ASR50_RS03935	COG0659	secondary active sulfate transmembrane transporter activity
ASR50_RS03945	COG1063	alcohol dehydrogenase
ASR50_RS03975	COG3540	Alkaline phosphatase
ASR50_RS04010	COG2124	cytochrome p450
ASR50_RS04020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASR50_RS04025	COG2192	nodulation
ASR50_RS04035	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS04040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASR50_RS04045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASR50_RS04045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASR50_RS04070	COG0753	catalase activity
ASR50_RS04080	COG0009	L-threonylcarbamoyladenylate synthase
ASR50_RS04100	COG0656	L-ascorbic acid biosynthetic process
ASR50_RS04105	COG1793	dna ligase
ASR50_RS04105	COG3285	dna ligase
ASR50_RS04130	COG1793	dna ligase
ASR50_RS04130	COG3285	dna ligase
ASR50_RS04140	COG0181	hydroxymethylbilane synthase activity
ASR50_RS04180	COG0366	Alpha amylase catalytic
ASR50_RS04190	COG3281	Trehalose synthase
ASR50_RS04195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ASR50_RS04200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ASR50_RS04240	COG2205	protein histidine kinase activity
ASR50_RS04240	COG4999	Histidine kinase
ASR50_RS04240	COG3437	response regulator, receiver
ASR50_RS04240	COG3850	Histidine kinase
ASR50_RS04255	COG1366	Belongs to the anti-sigma-factor antagonist family
ASR50_RS04260	COG1366	Belongs to the anti-sigma-factor antagonist family
ASR50_RS04265	COG2172	sigma factor antagonist activity
ASR50_RS04280	COG1252	NADH dehydrogenase
ASR50_RS04315	COG1982	Orn Lys Arg decarboxylase major
ASR50_RS04325	COG0477	Major facilitator Superfamily
ASR50_RS04335	COG0583	DNA-binding transcription factor activity
ASR50_RS04380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASR50_RS04410	COG2340	Cysteine-rich secretory protein family
ASR50_RS04425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASR50_RS04425	COG0515	serine threonine protein kinase
ASR50_RS04435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS04455	COG0667	Aldo Keto reductase
ASR50_RS04460	COG0328	RNA-DNA hybrid ribonuclease activity
ASR50_RS04475	COG0740	serine-type endopeptidase activity
ASR50_RS04480	COG0740	serine-type endopeptidase activity
ASR50_RS04485	COG1396	sequence-specific DNA binding
ASR50_RS04510	COG0667	Aldo Keto reductase
ASR50_RS04515	COG0583	DNA-binding transcription factor activity
ASR50_RS04525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASR50_RS04530	COG0346	lactoylglutathione lyase activity
ASR50_RS04625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASR50_RS04635	COG0515	serine threonine protein kinase
ASR50_RS04650	COG0494	nUDIX hydrolase
ASR50_RS04690	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ASR50_RS04700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASR50_RS04710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASR50_RS04715	COG1937	Protein conserved in bacteria
ASR50_RS04740	COG0516	GMP reductase activity
ASR50_RS04740	COG0517	IMP dehydrogenase activity
ASR50_RS04755	COG2376	Dihydroxyacetone kinase
ASR50_RS04760	COG1461	Dihydroxyacetone kinase
ASR50_RS04790	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASR50_RS04790	COG1902	pentaerythritol trinitrate reductase activity
ASR50_RS04805	COG2890	protein-(glutamine-N5) methyltransferase activity
ASR50_RS04810	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ASR50_RS04825	COG3458	cephalosporin-C deacetylase activity
ASR50_RS04830	COG2188	Transcriptional regulator
ASR50_RS04840	COG2226	methyltransferase
ASR50_RS04845	COG1686	Belongs to the peptidase S11 family
ASR50_RS04855	COG2186	Transcriptional regulator
ASR50_RS04865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASR50_RS04870	COG1993	acr, cog1993
ASR50_RS04875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASR50_RS04935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASR50_RS04940	COG2867	negative regulation of translational initiation
ASR50_RS04975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS05010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASR50_RS05035	COG0028	Belongs to the TPP enzyme family
ASR50_RS05045	COG1819	glycosyl
ASR50_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS05085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASR50_RS05090	COG1215	transferase activity, transferring glycosyl groups
ASR50_RS05125	COG1349	DNA-binding transcription factor activity
ASR50_RS05170	COG1940	carbohydrate kinase activity
ASR50_RS05175	COG2801	Transposase and inactivated derivatives
ASR50_RS05175	COG3415	Transposase
ASR50_RS05180	COG2813	Specifically methylates the guanine in position
ASR50_RS05185	COG3387	PFAM Glycoside hydrolase 15-related
ASR50_RS05215	COG2318	DinB family
ASR50_RS05240	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS05260	COG0673	inositol 2-dehydrogenase activity
ASR50_RS05265	COG4565	transcriptional regulatory protein
ASR50_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS05325	COG2197	response regulator
ASR50_RS05330	COG4585	Histidine kinase
ASR50_RS05345	COG0492	ferredoxin-NADP+ reductase activity
ASR50_RS05355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASR50_RS05360	COG1660	Displays ATPase and GTPase activities
ASR50_RS05400	COG3655	Transcriptional regulator
ASR50_RS05415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ASR50_RS05460	COG0584	glycerophosphoryl diester phosphodiesterase
ASR50_RS05500	COG0671	phosphoesterase, PA-phosphatase related
ASR50_RS05530	COG0154	amidase activity
ASR50_RS05540	COG0640	Transcriptional regulator
ASR50_RS05545	COG1902	pentaerythritol trinitrate reductase activity
ASR50_RS05570	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS05580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASR50_RS05605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASR50_RS05665	COG2072	flavoprotein involved in K transport
ASR50_RS05670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ASR50_RS05675	COG1132	(ABC) transporter
ASR50_RS05680	COG1846	Transcriptional regulator
ASR50_RS05685	COG1132	(ABC) transporter
ASR50_RS05690	COG1132	(ABC) transporter
ASR50_RS05700	COG0254	rRNA binding
ASR50_RS05715	COG1946	Acyl-CoA thioesterase
ASR50_RS05725	COG2018	Roadblock/LC7 domain
ASR50_RS05805	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS05810	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS05820	COG1476	TRANSCRIPTIONal
ASR50_RS05830	COG1793	dna ligase
ASR50_RS05840	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS05855	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS05865	COG0242	peptide deformylase activity
ASR50_RS05870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASR50_RS05875	COG3442	glutamine amidotransferase
ASR50_RS05880	COG0205	6-phosphofructokinase activity
ASR50_RS05890	COG3275	phosphorelay sensor kinase activity
ASR50_RS05895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASR50_RS05905	COG3279	Response regulator of the LytR AlgR family
ASR50_RS05910	COG1522	sequence-specific DNA binding
ASR50_RS05915	COG1834	amidinotransferase
ASR50_RS05920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASR50_RS05935	COG0698	ribose 5-phosphate isomerase
ASR50_RS05940	COG0204	Acyl-transferase
ASR50_RS05950	COG0829	nickel cation binding
ASR50_RS05955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ASR50_RS05965	COG0804	urea catabolic process
ASR50_RS05970	COG0832	Belongs to the urease beta subunit family
ASR50_RS05975	COG0831	urea catabolic process
ASR50_RS05980	COG1309	transcriptional regulator
ASR50_RS05995	COG0740	serine-type endopeptidase activity
ASR50_RS06005	COG0791	NLP P60 protein
ASR50_RS06030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASR50_RS06035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASR50_RS06040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ASR50_RS06045	COG2226	methyltransferase
ASR50_RS06060	COG0456	acetyltransferase
ASR50_RS06080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASR50_RS06105	COG4585	Histidine kinase
ASR50_RS06110	COG2197	response regulator
ASR50_RS06115	COG1940	carbohydrate kinase activity
ASR50_RS06120	COG2188	Transcriptional regulator
ASR50_RS06125	COG1595	DNA-templated transcription, initiation
ASR50_RS06130	COG0596	Alpha beta hydrolase
ASR50_RS06145	COG0626	cystathionine gamma-synthase activity
ASR50_RS06160	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS06175	COG1522	sequence-specific DNA binding
ASR50_RS06180	COG0419	ATPase involved in DNA repair
ASR50_RS06185	COG0420	3'-5' exonuclease activity
ASR50_RS06190	COG1739	Uncharacterized protein family UPF0029
ASR50_RS06210	COG1832	CoA-binding protein
ASR50_RS06230	COG0110	maltose O-acetyltransferase activity
ASR50_RS06265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASR50_RS06280	COG0183	Belongs to the thiolase family
ASR50_RS06290	COG1968	undecaprenyl-diphosphatase activity
ASR50_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS06310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASR50_RS06330	COG2318	DinB family
ASR50_RS06345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASR50_RS06380	COG0723	plastoquinol--plastocyanin reductase activity
ASR50_RS06395	COG0697	spore germination
ASR50_RS06485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASR50_RS06485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASR50_RS06495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ASR50_RS06515	COG1716	ATPase activity
ASR50_RS06535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ASR50_RS06570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASR50_RS06580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASR50_RS06585	COG1501	Belongs to the glycosyl hydrolase 31 family
ASR50_RS06595	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ASR50_RS06600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASR50_RS06605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASR50_RS06625	COG2018	Roadblock/LC7 domain
ASR50_RS06640	COG1414	Transcriptional regulator
ASR50_RS06665	COG2814	Major facilitator Superfamily
ASR50_RS06670	COG4336	lyase activity
ASR50_RS06675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ASR50_RS06680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ASR50_RS06685	COG1984	allophanate hydrolase subunit 2
ASR50_RS06710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASR50_RS06715	COG2364	Membrane
ASR50_RS06725	COG2270	Major facilitator Superfamily
ASR50_RS06735	COG3030	protein affecting phage T7 exclusion by the F plasmid
ASR50_RS06740	COG1216	Glycosyl transferase, family 2
ASR50_RS06765	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS06810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASR50_RS06815	COG0140	phosphoribosyl-ATP diphosphatase activity
ASR50_RS06820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASR50_RS06825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASR50_RS06825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASR50_RS06830	COG3201	nicotinamide mononucleotide transporter
ASR50_RS06840	COG0702	epimerase
ASR50_RS06845	COG1940	carbohydrate kinase activity
ASR50_RS06845	COG1846	Transcriptional regulator
ASR50_RS06850	COG0738	Major facilitator superfamily
ASR50_RS06860	COG2233	PERMEase
ASR50_RS06880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASR50_RS06900	COG0726	polysaccharide deacetylase
ASR50_RS06915	COG0531	amino acid
ASR50_RS06935	COG2390	Transcriptional regulator
ASR50_RS06940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASR50_RS06950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASR50_RS06965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASR50_RS06975	COG1758	RNA polymerase activity
ASR50_RS06980	COG0194	GDP metabolic process
ASR50_RS06990	COG0284	orotidine-5'-phosphate decarboxylase activity
ASR50_RS06995	COG0167	dihydroorotate dehydrogenase activity
ASR50_RS07000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASR50_RS07005	COG0505	Belongs to the CarA family
ASR50_RS07015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASR50_RS07020	COG0540	Belongs to the ATCase OTCase family
ASR50_RS07025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ASR50_RS07035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASR50_RS07040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASR50_RS07045	COG0006	proline dipeptidase activity
ASR50_RS07055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASR50_RS07060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASR50_RS07065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASR50_RS07075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASR50_RS07085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ASR50_RS07090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASR50_RS07105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASR50_RS07120	COG0124	histidyl-tRNA synthetase
ASR50_RS07130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASR50_RS07135	COG1196	nuclear chromosome segregation
ASR50_RS07140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASR50_RS07145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASR50_RS07150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASR50_RS07155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASR50_RS07165	COG2255	four-way junction helicase activity
ASR50_RS07170	COG0632	four-way junction helicase activity
ASR50_RS07175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASR50_RS07180	COG0217	transcriptional regulatory protein
ASR50_RS07185	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ASR50_RS07190	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ASR50_RS07200	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS07205	COG1560	Kdo2-lipid A biosynthetic process
ASR50_RS07210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASR50_RS07230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASR50_RS07245	COG5002	protein histidine kinase activity
ASR50_RS07245	COG2176	DNA-directed DNA polymerase activity
ASR50_RS07270	COG0395	ABC-type sugar transport system, permease component
ASR50_RS07275	COG1175	transmembrane transport
ASR50_RS07325	COG0512	Glutamine amidotransferase of anthranilate synthase
ASR50_RS07325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASR50_RS07380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASR50_RS07380	COG1648	precorrin-2 dehydrogenase activity
ASR50_RS07385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASR50_RS07400	COG1464	Belongs to the NlpA lipoprotein family
ASR50_RS07405	COG2011	ABC-type metal ion transport system permease component
ASR50_RS07410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASR50_RS07415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASR50_RS07445	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS07445	COG0204	Acyl-transferase
ASR50_RS07450	COG0477	Major facilitator Superfamily
ASR50_RS07465	COG0165	Argininosuccinate lyase
ASR50_RS07470	COG0137	argininosuccinate synthase activity
ASR50_RS07505	COG1438	arginine binding
ASR50_RS07510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASR50_RS07515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASR50_RS07520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ASR50_RS07525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASR50_RS07545	COG1653	transport
ASR50_RS07555	COG0395	ABC-type sugar transport system, permease component
ASR50_RS07580	COG0697	spore germination
ASR50_RS07590	COG1649	PFAM Uncharacterised BCR, COG1649
ASR50_RS07600	COG0583	DNA-binding transcription factor activity
ASR50_RS07625	COG0072	phenylalanine-tRNA ligase activity
ASR50_RS07625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASR50_RS07630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASR50_RS07635	COG5002	protein histidine kinase activity
ASR50_RS07640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASR50_RS07645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ASR50_RS07650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ASR50_RS07655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ASR50_RS07695	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS07700	COG0174	glutamine synthetase
ASR50_RS07705	COG2186	Transcriptional regulator
ASR50_RS07710	COG0531	amino acid
ASR50_RS07715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ASR50_RS07735	COG4176	ABC-type proline glycine betaine transport system permease component
ASR50_RS07740	COG4175	Glycine betaine
ASR50_RS07740	COG3448	diguanylate cyclase activity
ASR50_RS07745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASR50_RS07795	COG0805	protein transport
ASR50_RS07800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASR50_RS07820	COG2378	regulation of single-species biofilm formation
ASR50_RS07830	COG0545	Peptidyl-prolyl cis-trans isomerase
ASR50_RS07835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASR50_RS07845	COG1609	Transcriptional regulator
ASR50_RS07850	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASR50_RS07855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASR50_RS07865	COG4122	O-methyltransferase activity
ASR50_RS07870	COG1222	aaa ATPase
ASR50_RS07890	COG0517	IMP dehydrogenase activity
ASR50_RS07890	COG1994	Peptidase M50
ASR50_RS07900	COG2197	response regulator
ASR50_RS07905	COG4166	transmembrane transport
ASR50_RS07910	COG4166	transmembrane transport
ASR50_RS07915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASR50_RS07920	COG1410	methionine synthase
ASR50_RS07920	COG0646	methionine synthase
ASR50_RS07925	COG1414	Transcriptional regulator
ASR50_RS07930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASR50_RS07935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASR50_RS07940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASR50_RS07950	COG0215	cysteine-tRNA ligase activity
ASR50_RS07970	COG0598	Magnesium transport protein CorA
ASR50_RS07980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS07985	COG0667	Aldo Keto reductase
ASR50_RS07995	COG3415	Transposase
ASR50_RS07995	COG2801	Transposase and inactivated derivatives
ASR50_RS08020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASR50_RS08030	COG3012	SEC-C Motif Domain Protein
ASR50_RS08035	COG0251	oxidation-reduction process
ASR50_RS08040	COG1733	regulation of RNA biosynthetic process
ASR50_RS08045	COG2186	Transcriptional regulator
ASR50_RS08050	COG3265	gluconokinase activity
ASR50_RS08080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ASR50_RS08085	COG2149	membrane
ASR50_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS08115	COG3876	Protein conserved in bacteria
ASR50_RS08150	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS08160	COG0640	Transcriptional regulator
ASR50_RS08175	COG3842	ATPase activity
ASR50_RS08190	COG2851	Citrate transporter
ASR50_RS08195	COG0243	molybdopterin cofactor binding
ASR50_RS08200	COG1309	transcriptional regulator
ASR50_RS08210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ASR50_RS08215	COG2188	Transcriptional regulator
ASR50_RS08250	COG1595	DNA-templated transcription, initiation
ASR50_RS08280	COG2755	lipolytic protein G-D-S-L family
ASR50_RS08300	COG1725	Transcriptional regulator
ASR50_RS08350	COG0587	DNA-directed DNA polymerase activity
ASR50_RS08375	COG1799	cell septum assembly
ASR50_RS08380	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS08385	COG0477	Major facilitator Superfamily
ASR50_RS08395	COG0671	phosphoesterase, PA-phosphatase related
ASR50_RS08405	COG3942	CHAP domain
ASR50_RS08405	COG1388	LysM domain
ASR50_RS08430	COG3293	Transposase
ASR50_RS08435	COG3293	Transposase
ASR50_RS08475	COG1160	GTP binding
ASR50_RS08485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASR50_RS08500	COG0723	plastoquinol--plastocyanin reductase activity
ASR50_RS08515	COG1051	belongs to the nudix hydrolase family
ASR50_RS08515	COG1056	cytidyltransferase-related domain
ASR50_RS08520	COG1187	pseudouridine synthase activity
ASR50_RS08525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ASR50_RS08530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ASR50_RS08545	COG0686	Belongs to the AlaDH PNT family
ASR50_RS08555	COG0494	nUDIX hydrolase
ASR50_RS08560	COG0504	CTP synthase activity
ASR50_RS08565	COG3387	PFAM Glycoside hydrolase 15-related
ASR50_RS08580	COG0497	DNA recombination
ASR50_RS08585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASR50_RS08605	COG1120	ATPase activity
ASR50_RS08610	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASR50_RS08615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASR50_RS08620	COG0647	UMP catabolic process
ASR50_RS08650	COG2094	Belongs to the DNA glycosylase MPG family
ASR50_RS08675	COG2094	Belongs to the DNA glycosylase MPG family
ASR50_RS08685	COG1881	PFAM PEBP family protein
ASR50_RS08705	COG1119	ATPase activity
ASR50_RS08720	COG2197	response regulator
ASR50_RS08725	COG4585	Histidine kinase
ASR50_RS08735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ASR50_RS08745	COG1716	ATPase activity
ASR50_RS08745	COG0842	Transport permease protein
ASR50_RS08745	COG1131	(ABC) transporter
ASR50_RS08755	COG3830	Belongs to the UPF0237 family
ASR50_RS08755	COG0560	Phosphoserine phosphatase
ASR50_RS08760	COG0588	phosphoglycerate mutase activity
ASR50_RS08775	COG2186	Transcriptional regulator
ASR50_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS08790	COG0312	modulator of DNA gyrase
ASR50_RS08800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASR50_RS08820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASR50_RS08825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASR50_RS08840	COG1404	Belongs to the peptidase S8 family
ASR50_RS08855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASR50_RS08880	COG3387	PFAM Glycoside hydrolase 15-related
ASR50_RS08920	COG1024	Enoyl-CoA hydratase
ASR50_RS08930	COG0488	(ABC) transporter
ASR50_RS08950	COG0235	Class ii aldolase
ASR50_RS08965	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ASR50_RS08970	COG1492	cobalamin metabolic process
ASR50_RS08990	COG1797	cobyrinic acid a,c-diamide synthase activity
ASR50_RS09055	COG0765	amino acid transport
ASR50_RS09065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASR50_RS09070	COG0456	acetyltransferase
ASR50_RS09075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ASR50_RS09080	COG1917	Cupin 2, conserved barrel domain protein
ASR50_RS09085	COG5285	phytanoyl-CoA dioxygenase
ASR50_RS09090	COG3844	kynureninase activity
ASR50_RS09110	COG4585	Histidine kinase
ASR50_RS09115	COG2197	response regulator
ASR50_RS09125	COG1414	Transcriptional regulator
ASR50_RS09135	COG0768	penicillin binding
ASR50_RS09140	COG2252	PERMEase
ASR50_RS09155	COG3866	Pectate lyase
ASR50_RS09160	COG2755	lipolytic protein G-D-S-L family
ASR50_RS09170	COG3507	Belongs to the glycosyl hydrolase 43 family
ASR50_RS09185	COG0395	ABC-type sugar transport system, permease component
ASR50_RS09190	COG1175	transmembrane transport
ASR50_RS09200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASR50_RS09205	COG1802	Transcriptional regulator
ASR50_RS09225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASR50_RS09230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASR50_RS09235	COG1349	DNA-binding transcription factor activity
ASR50_RS09250	COG0395	ABC-type sugar transport system, permease component
ASR50_RS09255	COG1063	alcohol dehydrogenase
ASR50_RS09290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASR50_RS09310	COG2171	N-acyltransferase activity
ASR50_RS09315	COG3226	Transcriptional regulator
ASR50_RS09320	COG2076	Multidrug Resistance protein
ASR50_RS09325	COG2151	metal-sulfur cluster biosynthetic enzyme
ASR50_RS09330	COG0822	iron-sulfur transferase activity
ASR50_RS09335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASR50_RS09340	COG0396	ATPase activity
ASR50_RS09350	COG0719	Fe-S assembly protein
ASR50_RS09365	COG1131	(ABC) transporter
ASR50_RS09375	COG1612	heme a metabolic process
ASR50_RS09395	COG0109	protoheme IX farnesyltransferase activity
ASR50_RS09405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASR50_RS09420	COG0363	glucosamine-6-phosphate deaminase activity
ASR50_RS09425	COG0395	ABC-type sugar transport system, permease component
ASR50_RS09430	COG1175	transmembrane transport
ASR50_RS09435	COG1653	transport
ASR50_RS09440	COG0366	Alpha amylase catalytic
ASR50_RS09455	COG1136	(ABC) transporter
ASR50_RS09455	COG0577	efflux transmembrane transporter activity
ASR50_RS09470	COG0166	Belongs to the GPI family
ASR50_RS09480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASR50_RS09485	COG0149	triose-phosphate isomerase activity
ASR50_RS09490	COG0126	phosphoglycerate kinase activity
ASR50_RS09495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASR50_RS09505	COG1481	regulation of sporulation
ASR50_RS09510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ASR50_RS09515	COG1660	Displays ATPase and GTPase activities
ASR50_RS09520	COG0322	excinuclease ABC activity
ASR50_RS09535	COG1609	Transcriptional regulator
ASR50_RS09545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASR50_RS09555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASR50_RS09560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ASR50_RS09565	COG0387	Pfam Sodium calcium exchanger
ASR50_RS09585	COG0556	nucleotide-excision repair
ASR50_RS09595	COG0584	glycerophosphoryl diester phosphodiesterase
ASR50_RS09600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASR50_RS09610	COG2313	pseudouridylate synthase activity
ASR50_RS09675	COG0402	S-adenosylhomocysteine deaminase activity
ASR50_RS09695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASR50_RS09710	COG2267	carboxylic ester hydrolase activity
ASR50_RS09725	COG2226	methyltransferase
ASR50_RS09740	COG0237	dephospho-CoA kinase activity
ASR50_RS09750	COG0539	negative regulation of cytoplasmic translation
ASR50_RS09755	COG2226	methyltransferase
ASR50_RS09760	COG1643	Atp-dependent helicase
ASR50_RS09790	COG2050	protein possibly involved in aromatic compounds catabolism
ASR50_RS09845	COG0737	Belongs to the 5'-nucleotidase family
ASR50_RS09860	COG0287	Prephenate dehydrogenase
ASR50_RS09860	COG1605	Chorismate mutase
ASR50_RS09885	COG0067	glutamate synthase
ASR50_RS09885	COG0070	glutamate synthase
ASR50_RS09885	COG0069	glutamate synthase activity
ASR50_RS09895	COG1397	ADP-ribosylglycohydrolase
ASR50_RS09915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS09925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASR50_RS09935	COG0159	tryptophan synthase activity
ASR50_RS09940	COG0133	tryptophan synthase activity
ASR50_RS09945	COG0134	indole-3-glycerol-phosphate synthase activity
ASR50_RS09965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASR50_RS09970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASR50_RS09985	COG0107	imidazoleglycerol-phosphate synthase activity
ASR50_RS09990	COG0251	oxidation-reduction process
ASR50_RS09995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASR50_RS10000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASR50_RS10010	COG0131	Imidazoleglycerol-phosphate dehydratase
ASR50_RS10015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASR50_RS10020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASR50_RS10060	COG1432	Conserved Protein
ASR50_RS10065	COG0587	DNA-directed DNA polymerase activity
ASR50_RS10120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ASR50_RS10130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASR50_RS10135	COG3599	regulation of cell shape
ASR50_RS10145	COG1799	cell septum assembly
ASR50_RS10155	COG1496	oxidoreductase activity
ASR50_RS10160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASR50_RS10165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ASR50_RS10170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ASR50_RS10180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASR50_RS10185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASR50_RS10195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ASR50_RS10210	COG0275	rRNA processing
ASR50_RS10220	COG0714	Associated with various cellular activities
ASR50_RS10240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASR50_RS10250	COG1129	ABC transporter
ASR50_RS10260	COG1309	transcriptional regulator
ASR50_RS10280	COG0352	thiamine-phosphate diphosphorylase activity
ASR50_RS10290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASR50_RS10295	COG2022	thiamine diphosphate biosynthetic process
ASR50_RS10295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASR50_RS10305	COG2022	thiamine diphosphate biosynthetic process
ASR50_RS10310	COG0515	serine threonine protein kinase
ASR50_RS10310	COG2815	serine threonine protein kinase
ASR50_RS10315	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ASR50_RS10320	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ASR50_RS10325	COG2193	ferroxidase activity
ASR50_RS10335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ASR50_RS10345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASR50_RS10350	COG0205	6-phosphofructokinase activity
ASR50_RS10360	COG4585	Histidine kinase
ASR50_RS10385	COG1940	carbohydrate kinase activity
ASR50_RS10395	COG0003	Pfam Anion-transporting ATPase
ASR50_RS10435	COG3103	Sh3 type 3 domain protein
ASR50_RS10435	COG0791	NLP P60 protein
ASR50_RS10435	COG1388	LysM domain
ASR50_RS10460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASR50_RS10465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASR50_RS10470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASR50_RS10475	COG0723	plastoquinol--plastocyanin reductase activity
ASR50_RS10480	COG2010	Cytochrome c
ASR50_RS10485	COG1845	cytochrome c oxidase, subunit III
ASR50_RS10495	COG1376	ErfK ybiS ycfS ynhG family protein
ASR50_RS10505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ASR50_RS10510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ASR50_RS10515	COG1104	cysteine desulfurase activity
ASR50_RS10520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASR50_RS10540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ASR50_RS10545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASR50_RS10550	COG2197	response regulator
ASR50_RS10555	COG4585	Histidine kinase
ASR50_RS10595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASR50_RS10605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ASR50_RS10620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASR50_RS10625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASR50_RS10630	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASR50_RS10640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASR50_RS10685	COG0321	lipoyl(octanoyl) transferase activity
ASR50_RS10690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASR50_RS10710	COG0174	glutamine synthetase
ASR50_RS10730	COG1136	(ABC) transporter
ASR50_RS10745	COG4585	Histidine kinase
ASR50_RS10770	COG0745	RESPONSE REGULATOR receiver
ASR50_RS10785	COG2197	response regulator
ASR50_RS10805	COG1309	transcriptional regulator
ASR50_RS10830	COG0366	Alpha amylase catalytic
ASR50_RS10835	COG3833	ABC-type maltose transport systems, permease component
ASR50_RS10840	COG1175	transmembrane transport
ASR50_RS10845	COG2182	Extracellular solute-binding protein
ASR50_RS10850	COG1609	Transcriptional regulator
ASR50_RS10860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASR50_RS10890	COG2318	DinB family
ASR50_RS10895	COG0174	glutamine synthetase
ASR50_RS10905	COG1959	2 iron, 2 sulfur cluster binding
ASR50_RS10920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASR50_RS10920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASR50_RS10935	COG0477	Major facilitator Superfamily
ASR50_RS10940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASR50_RS10960	COG1994	Peptidase M50
ASR50_RS11000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASR50_RS11025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASR50_RS11030	COG1120	ATPase activity
ASR50_RS11045	COG0584	glycerophosphoryl diester phosphodiesterase
ASR50_RS11070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASR50_RS11075	COG2814	Major facilitator Superfamily
ASR50_RS11080	COG0673	inositol 2-dehydrogenase activity
ASR50_RS11085	COG3540	Alkaline phosphatase
ASR50_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS11095	COG0667	Aldo Keto reductase
ASR50_RS11110	COG2124	cytochrome p450
ASR50_RS11115	COG2124	cytochrome p450
ASR50_RS11160	COG3022	response to hydroperoxide
ASR50_RS11165	COG0800	Aldolase
ASR50_RS11180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASR50_RS11190	COG2030	dehydratase
ASR50_RS11200	COG0477	Major facilitator Superfamily
ASR50_RS11210	COG2247	cell wall binding repeat
ASR50_RS11210	COG0860	N-Acetylmuramoyl-L-alanine amidase
ASR50_RS11235	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS11240	COG1309	transcriptional regulator
ASR50_RS11245	COG1657	PFAM Prenyltransferase squalene oxidase
ASR50_RS11260	COG3845	ABC transporter
ASR50_RS11295	COG4122	O-methyltransferase activity
ASR50_RS11335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASR50_RS11355	COG2259	Doxx family
ASR50_RS11400	COG4585	Histidine kinase
ASR50_RS11405	COG0586	Pfam SNARE associated Golgi protein
ASR50_RS11415	COG1358	cellular component organization or biogenesis
ASR50_RS11460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASR50_RS11470	COG0477	Major facilitator Superfamily
ASR50_RS11475	COG1309	transcriptional regulator
ASR50_RS11495	COG0667	Aldo Keto reductase
ASR50_RS11500	COG0789	Transcriptional regulator
ASR50_RS11520	COG0326	Molecular chaperone. Has ATPase activity
ASR50_RS11545	COG1741	Belongs to the pirin family
ASR50_RS11560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASR50_RS11565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASR50_RS11570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASR50_RS11595	COG1280	lysine exporter protein (LysE YggA)
ASR50_RS11605	COG2130	NADP-dependent
ASR50_RS11650	COG4213	ABC transporter substrate-binding protein
ASR50_RS11660	COG4214	carbohydrate transport
ASR50_RS11670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASR50_RS11705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ASR50_RS11730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ASR50_RS11740	COG1127	ABC transporter
ASR50_RS11800	COG3386	PFAM SMP-30 Gluconolaconase
ASR50_RS11805	COG1414	Transcriptional regulator
ASR50_RS11830	COG4981	capsule polysaccharide biosynthetic process
ASR50_RS11870	COG2186	Transcriptional regulator
ASR50_RS11880	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS11885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ASR50_RS11885	COG0825	malonyl-CoA metabolic process
ASR50_RS11890	COG1077	Cell shape determining protein MreB Mrl
ASR50_RS11920	COG1070	Carbohydrate kinase
ASR50_RS11935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASR50_RS11940	COG0358	DNA primase activity
ASR50_RS11950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ASR50_RS11960	COG2949	membrane
ASR50_RS12020	COG2146	nitrite reductase [NAD(P)H] activity
ASR50_RS12020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASR50_RS12045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASR50_RS12045	COG0574	Belongs to the PEP-utilizing enzyme family
ASR50_RS12065	COG3415	Transposase
ASR50_RS12065	COG2801	Transposase and inactivated derivatives
ASR50_RS12080	COG0667	Aldo Keto reductase
ASR50_RS12085	COG0423	glycine-tRNA ligase activity
ASR50_RS12090	COG0803	Belongs to the bacterial solute-binding protein 9 family
ASR50_RS12090	COG3443	Belongs to the bacterial solute-binding protein 9 family
ASR50_RS12095	COG1121	(ABC) transporter
ASR50_RS12100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASR50_RS12110	COG3619	membrane
ASR50_RS12115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASR50_RS12120	COG1381	Involved in DNA repair and RecF pathway recombination
ASR50_RS12135	COG2197	response regulator
ASR50_RS12140	COG4585	Histidine kinase
ASR50_RS12145	COG2409	Drug exporters of the RND superfamily
ASR50_RS12190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASR50_RS12225	COG2723	6-phospho-beta-galactosidase activity
ASR50_RS12230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASR50_RS12265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ASR50_RS12275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASR50_RS12280	COG4948	Mandelate Racemase Muconate Lactonizing
ASR50_RS12290	COG1234	tRNA 3'-trailer cleavage
ASR50_RS12295	COG0537	adenosine 5'-monophosphoramidase activity
ASR50_RS12300	COG4946	Tricorn protease homolog
ASR50_RS12300	COG0793	Belongs to the peptidase S41A family
ASR50_RS12320	COG0484	heat shock protein binding
ASR50_RS12325	COG1420	regulation of RNA biosynthetic process
ASR50_RS12360	COG0481	GTPase activity
ASR50_RS12365	COG0268	Binds directly to 16S ribosomal RNA
ASR50_RS12390	COG1596	polysaccharide export
ASR50_RS12390	COG1555	photosystem II stabilization
ASR50_RS12395	COG1307	EDD domain protein, DegV family
ASR50_RS12405	COG0495	leucyl-tRNA aminoacylation
ASR50_RS12415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ASR50_RS12435	COG0588	phosphoglycerate mutase activity
ASR50_RS12440	COG0799	negative regulation of ribosome biogenesis
ASR50_RS12450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ASR50_RS12455	COG0501	Belongs to the peptidase M48B family
ASR50_RS12470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASR50_RS12480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASR50_RS12495	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS12500	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS12510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ASR50_RS12510	COG2755	lipolytic protein G-D-S-L family
ASR50_RS12515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASR50_RS12520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASR50_RS12525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASR50_RS12535	COG1530	ribonuclease E activity
ASR50_RS12565	COG3293	Transposase
ASR50_RS12580	COG0772	Belongs to the SEDS family
ASR50_RS12585	COG0768	penicillin binding
ASR50_RS12600	COG1077	Cell shape determining protein MreB Mrl
ASR50_RS12605	COG0105	UTP biosynthetic process
ASR50_RS12615	COG0285	dihydrofolate synthase activity
ASR50_RS12625	COG0525	valine-tRNA ligase activity
ASR50_RS12640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASR50_RS12645	COG0740	serine-type endopeptidase activity
ASR50_RS12650	COG0740	serine-type endopeptidase activity
ASR50_RS12655	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASR50_RS12680	COG3594	Acyltransferase
ASR50_RS12695	COG4552	Acetyltransferase involved in intracellular survival and related
ASR50_RS12710	COG1113	amino acid transport
ASR50_RS12715	COG1268	BioY protein
ASR50_RS12725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ASR50_RS12735	COG1116	anion transmembrane transporter activity
ASR50_RS12750	COG1113	amino acid transport
ASR50_RS12760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ASR50_RS12810	COG1309	transcriptional regulator
ASR50_RS12825	COG0697	spore germination
ASR50_RS12830	COG1846	Transcriptional regulator
ASR50_RS12850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ASR50_RS12850	COG3291	Pkd domain containing protein
ASR50_RS12860	COG1136	(ABC) transporter
ASR50_RS12875	COG0668	transmembrane transport
ASR50_RS12885	COG1486	melibiose metabolic process
ASR50_RS12900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASR50_RS12945	COG1136	(ABC) transporter
ASR50_RS13065	COG0629	single-stranded DNA binding
ASR50_RS13070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASR50_RS13135	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS13140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASR50_RS13150	COG0728	peptidoglycan biosynthetic process
ASR50_RS13160	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS13180	COG0492	ferredoxin-NADP+ reductase activity
ASR50_RS13195	COG1131	(ABC) transporter
ASR50_RS13230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASR50_RS13250	COG0346	lactoylglutathione lyase activity
ASR50_RS13265	COG0596	Alpha beta hydrolase
ASR50_RS13305	COG1129	ABC transporter
ASR50_RS13315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASR50_RS13320	COG1869	D-ribose catabolic process
ASR50_RS13335	COG0673	inositol 2-dehydrogenase activity
ASR50_RS13350	COG2197	response regulator
ASR50_RS13375	COG1472	Belongs to the glycosyl hydrolase 3 family
ASR50_RS13380	COG3293	Transposase
ASR50_RS13405	COG2356	endonuclease I
ASR50_RS13445	COG0028	Belongs to the TPP enzyme family
ASR50_RS13455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASR50_RS13470	COG3321	synthase
ASR50_RS13470	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS13470	COG0604	alcohol dehydrogenase
ASR50_RS13480	COG1946	Acyl-CoA thioesterase
ASR50_RS13490	COG1309	transcriptional regulator
ASR50_RS13495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASR50_RS13510	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS13530	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ASR50_RS13555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASR50_RS13560	COG0589	response to stress
ASR50_RS13570	COG4977	sequence-specific DNA binding
ASR50_RS13575	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ASR50_RS13610	COG3979	chitinase
ASR50_RS13620	COG0745	RESPONSE REGULATOR receiver
ASR50_RS13650	COG1309	transcriptional regulator
ASR50_RS13655	COG0406	alpha-ribazole phosphatase activity
ASR50_RS13680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASR50_RS13735	COG0765	amino acid transport
ASR50_RS13740	COG0765	amino acid transport
ASR50_RS13745	COG1126	abc transporter atp-binding protein
ASR50_RS13760	COG3397	chitin binding
ASR50_RS13810	COG1940	carbohydrate kinase activity
ASR50_RS13815	COG0673	inositol 2-dehydrogenase activity
ASR50_RS13820	COG4702	Belongs to the UPF0303 family
ASR50_RS13835	COG0706	membrane insertase activity
ASR50_RS13835	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
ASR50_RS13860	COG2267	carboxylic ester hydrolase activity
ASR50_RS13925	COG1280	lysine exporter protein (LysE YggA)
ASR50_RS13940	COG3226	Transcriptional regulator
ASR50_RS13965	COG2814	Major facilitator Superfamily
ASR50_RS13970	COG2733	membrane
ASR50_RS13985	COG4555	ABC transporter
ASR50_RS14000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASR50_RS14040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASR50_RS14050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASR50_RS14055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASR50_RS14060	COG1263	PTS System
ASR50_RS14065	COG1263	PTS System
ASR50_RS14070	COG1234	tRNA 3'-trailer cleavage
ASR50_RS14095	COG1113	amino acid transport
ASR50_RS14100	COG1115	amino acid carrier protein
ASR50_RS14110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASR50_RS14120	COG1335	isochorismatase
ASR50_RS14150	COG0277	FAD linked oxidase domain protein
ASR50_RS14160	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ASR50_RS14170	COG1174	glycine betaine transport
ASR50_RS14175	COG1125	glycine betaine transport
ASR50_RS14175	COG0517	IMP dehydrogenase activity
ASR50_RS14180	COG1174	glycine betaine transport
ASR50_RS14200	COG1061	Type III restriction enzyme res subunit
ASR50_RS14220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ASR50_RS14235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ASR50_RS14240	COG0395	ABC-type sugar transport system, permease component
ASR50_RS14260	COG1678	Uncharacterized ACR, COG1678
ASR50_RS14265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASR50_RS14270	COG0776	regulation of translation
ASR50_RS14280	COG3973	AAA domain
ASR50_RS14305	COG2223	nitrite transmembrane transporter activity
ASR50_RS14340	COG1609	Transcriptional regulator
ASR50_RS14350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASR50_RS14355	COG0793	Belongs to the peptidase S41A family
ASR50_RS14365	COG2884	Cell division ATP-binding protein ftsE
ASR50_RS14380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASR50_RS14385	COG3415	Transposase
ASR50_RS14385	COG2801	Transposase and inactivated derivatives
ASR50_RS14390	COG0515	serine threonine protein kinase
ASR50_RS14395	COG0515	serine threonine protein kinase
ASR50_RS14410	COG1175	transmembrane transport
ASR50_RS14415	COG0395	ABC-type sugar transport system, permease component
ASR50_RS14420	COG1216	Glycosyl transferase, family 2
ASR50_RS14425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ASR50_RS14430	COG0463	Glycosyl transferase, family 2
ASR50_RS14430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ASR50_RS14445	COG1764	response to oxidative stress
ASR50_RS14450	COG1846	Transcriptional regulator
ASR50_RS14455	COG1215	transferase activity, transferring glycosyl groups
ASR50_RS14470	COG1134	teichoic acid transport
ASR50_RS14475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ASR50_RS14480	COG1215	transferase activity, transferring glycosyl groups
ASR50_RS14490	COG2902	Dehydrogenase
ASR50_RS14510	COG0653	protein targeting
ASR50_RS14520	COG3214	Protein conserved in bacteria
ASR50_RS14525	COG2197	response regulator
ASR50_RS14530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASR50_RS14540	COG0823	Involved in the tonB-independent uptake of proteins
ASR50_RS14545	COG5000	phosphorelay sensor kinase activity
ASR50_RS14545	COG5002	protein histidine kinase activity
ASR50_RS14550	COG0745	RESPONSE REGULATOR receiver
ASR50_RS14555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ASR50_RS14575	COG0714	Associated with various cellular activities
ASR50_RS14580	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ASR50_RS14605	COG0180	Tryptophanyl-tRNA synthetase
ASR50_RS14610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASR50_RS14620	COG1129	ABC transporter
ASR50_RS14620	COG0842	Transport permease protein
ASR50_RS14625	COG2226	methyltransferase
ASR50_RS14645	COG0129	dihydroxy-acid dehydratase activity
ASR50_RS14650	COG1309	transcriptional regulator
ASR50_RS14655	COG1082	Xylose isomerase domain protein TIM barrel
ASR50_RS14660	COG0248	Ppx GppA phosphatase
ASR50_RS14680	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ASR50_RS14705	COG1194	a g-specific adenine glycosylase
ASR50_RS14710	COG1595	DNA-templated transcription, initiation
ASR50_RS14720	COG0745	RESPONSE REGULATOR receiver
ASR50_RS14725	COG2205	protein histidine kinase activity
ASR50_RS14740	COG0739	heme binding
ASR50_RS14765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ASR50_RS14780	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ASR50_RS14790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASR50_RS14795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ASR50_RS14815	COG1660	Displays ATPase and GTPase activities
ASR50_RS14820	COG2197	response regulator
ASR50_RS14835	COG0649	NAD binding
ASR50_RS14840	COG3402	PFAM membrane-flanked domain
ASR50_RS14865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASR50_RS14880	COG0302	gtp cyclohydrolase
ASR50_RS14895	COG0037	tRNA processing
ASR50_RS14905	COG2027	D-alanyl-D-alanine carboxypeptidase
ASR50_RS14910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ASR50_RS14920	COG0586	Pfam SNARE associated Golgi protein
ASR50_RS14925	COG0789	Transcriptional regulator
ASR50_RS14935	COG0076	glutamate decarboxylase activity
ASR50_RS14955	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS14990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASR50_RS14990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASR50_RS14995	COG3903	Transcriptional regulator
ASR50_RS14995	COG3629	intracellular signal transduction
ASR50_RS15015	COG2197	response regulator
ASR50_RS15025	COG1131	(ABC) transporter
ASR50_RS15030	COG4585	Histidine kinase
ASR50_RS15050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASR50_RS15055	COG1754	DNA topoisomerase type I activity
ASR50_RS15055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASR50_RS15065	COG2264	protein methyltransferase activity
ASR50_RS15075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ASR50_RS15080	COG2172	sigma factor antagonist activity
ASR50_RS15085	COG1366	Belongs to the anti-sigma-factor antagonist family
ASR50_RS15155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASR50_RS15160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASR50_RS15170	COG2267	carboxylic ester hydrolase activity
ASR50_RS15215	COG0003	Pfam Anion-transporting ATPase
ASR50_RS15225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASR50_RS15235	COG1408	metallophosphoesterase
ASR50_RS15300	COG0475	glutathione-regulated potassium exporter activity
ASR50_RS15340	COG1595	DNA-templated transcription, initiation
ASR50_RS15370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASR50_RS15375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASR50_RS15405	COG1846	Transcriptional regulator
ASR50_RS15410	COG0693	protein deglycase activity
ASR50_RS15415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASR50_RS15420	COG1802	Transcriptional regulator
ASR50_RS15435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ASR50_RS15450	COG1131	(ABC) transporter
ASR50_RS15455	COG3559	Exporter of polyketide antibiotics
ASR50_RS15475	COG2197	response regulator
ASR50_RS15480	COG4585	Histidine kinase
ASR50_RS15485	COG2197	response regulator
ASR50_RS15490	COG4585	Histidine kinase
ASR50_RS15510	COG3844	kynureninase activity
ASR50_RS15525	COG0477	Major facilitator Superfamily
ASR50_RS15530	COG0191	fructose-bisphosphate aldolase activity
ASR50_RS15535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASR50_RS15550	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ASR50_RS15615	COG0542	response to heat
ASR50_RS15645	COG4213	ABC transporter substrate-binding protein
ASR50_RS15650	COG0789	Transcriptional regulator
ASR50_RS15655	COG0484	heat shock protein binding
ASR50_RS15660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASR50_RS15665	COG0443	Heat shock 70 kDa protein
ASR50_RS15670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASR50_RS15675	COG0247	lactate metabolic process
ASR50_RS15675	COG2181	nitrate reductase activity
ASR50_RS15695	COG0464	growth
ASR50_RS15785	COG1063	alcohol dehydrogenase
ASR50_RS15800	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASR50_RS15805	COG0717	Belongs to the dCTP deaminase family
ASR50_RS15985	COG2188	Transcriptional regulator
ASR50_RS15995	COG2188	Transcriptional regulator
ASR50_RS16065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ASR50_RS16075	COG2205	protein histidine kinase activity
ASR50_RS16080	COG0745	RESPONSE REGULATOR receiver
ASR50_RS16140	COG2208	phosphoserine phosphatase activity
ASR50_RS16140	COG1366	Belongs to the anti-sigma-factor antagonist family
ASR50_RS16140	COG2172	sigma factor antagonist activity
ASR50_RS16150	COG2197	response regulator
ASR50_RS16165	COG1595	DNA-templated transcription, initiation
ASR50_RS16175	COG4213	ABC transporter substrate-binding protein
ASR50_RS16200	COG0583	DNA-binding transcription factor activity
ASR50_RS16210	COG1278	Cold shock
ASR50_RS16240	COG2409	Drug exporters of the RND superfamily
ASR50_RS16255	COG0366	Alpha amylase catalytic
ASR50_RS16265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASR50_RS16290	COG1653	transport
ASR50_RS16320	COG2801	Transposase and inactivated derivatives
ASR50_RS16320	COG3415	Transposase
ASR50_RS16330	COG0604	alcohol dehydrogenase
ASR50_RS16345	COG0515	serine threonine protein kinase
ASR50_RS16350	COG0515	serine threonine protein kinase
ASR50_RS16360	COG0022	dehydrogenase e1 component
ASR50_RS16365	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASR50_RS16410	COG1362	aminopeptidase activity
ASR50_RS16415	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS16425	COG1741	Belongs to the pirin family
ASR50_RS16435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASR50_RS16460	COG4221	oxidoreductase activity
ASR50_RS16465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASR50_RS16480	COG0583	DNA-binding transcription factor activity
ASR50_RS16500	COG3415	Transposase
ASR50_RS16500	COG2801	Transposase and inactivated derivatives
ASR50_RS16520	COG0303	'Molybdopterin
ASR50_RS16545	COG1522	sequence-specific DNA binding
ASR50_RS16555	COG1309	transcriptional regulator
ASR50_RS16560	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASR50_RS16585	COG3396	Phenylacetate-CoA oxygenase
ASR50_RS16590	COG3460	Phenylacetate-CoA oxygenase
ASR50_RS16595	COG3396	Phenylacetate-CoA oxygenase
ASR50_RS16600	COG2151	metal-sulfur cluster biosynthetic enzyme
ASR50_RS16630	COG1716	ATPase activity
ASR50_RS16635	COG1716	ATPase activity
ASR50_RS16650	COG0768	penicillin binding
ASR50_RS16655	COG0515	serine threonine protein kinase
ASR50_RS16660	COG3764	Sortase (surface protein transpeptidase)
ASR50_RS16665	COG3764	Sortase (surface protein transpeptidase)
ASR50_RS16690	COG0705	Rhomboid family
ASR50_RS16715	COG0515	serine threonine protein kinase
ASR50_RS16755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASR50_RS16760	COG0187	DNA topoisomerase II activity
ASR50_RS16765	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ASR50_RS16770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASR50_RS16775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ASR50_RS16780	COG0592	DNA-directed DNA polymerase activity
ASR50_RS16785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASR50_RS16790	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ASR50_RS16800	COG0706	membrane insertase activity
ASR50_RS16810	COG0357	Ribosomal RNA small subunit methyltransferase G
ASR50_RS16815	COG1192	Involved in chromosome partitioning
ASR50_RS16830	COG3118	belongs to the thioredoxin family
ASR50_RS16835	COG0492	ferredoxin-NADP+ reductase activity
ASR50_RS16845	COG1595	DNA-templated transcription, initiation
ASR50_RS16865	COG0617	tRNA 3'-terminal CCA addition
ASR50_RS16880	COG1260	myo-inositol-1-phosphate synthase
ASR50_RS16890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASR50_RS16915	COG0360	Binds together with S18 to 16S ribosomal RNA
ASR50_RS16920	COG0629	single-stranded DNA binding
ASR50_RS16925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASR50_RS16930	COG0359	binds to the 23S rRNA
ASR50_RS16940	COG0305	Participates in initiation and elongation during chromosome replication
ASR50_RS16960	COG2814	Major facilitator Superfamily
ASR50_RS16985	COG0626	cystathionine gamma-synthase activity
ASR50_RS16990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASR50_RS16995	COG1950	PFAM Membrane protein of
ASR50_RS17000	COG0662	Cupin 2, conserved barrel domain protein
ASR50_RS17025	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASR50_RS17045	COG1609	Transcriptional regulator
ASR50_RS17050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASR50_RS17055	COG1271	oxidase subunit
ASR50_RS17060	COG1294	oxidase, subunit
ASR50_RS17065	COG4988	ABC transporter
ASR50_RS17070	COG0741	lytic transglycosylase activity
ASR50_RS17070	COG0739	heme binding
ASR50_RS17070	COG1196	nuclear chromosome segregation
ASR50_RS17075	COG0561	phosphatase activity
ASR50_RS17080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS17090	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ASR50_RS17100	COG1131	(ABC) transporter
ASR50_RS17125	COG0561	phosphatase activity
ASR50_RS17130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASR50_RS17140	COG2837	iron assimilation
ASR50_RS17155	COG1999	signal sequence binding
ASR50_RS17175	COG0006	proline dipeptidase activity
ASR50_RS17195	COG0653	protein targeting
ASR50_RS17210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASR50_RS17225	COG0596	Alpha beta hydrolase
ASR50_RS17225	COG2945	thiolester hydrolase activity
ASR50_RS17265	COG1595	DNA-templated transcription, initiation
ASR50_RS17270	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS17275	COG0784	Response regulator, receiver
ASR50_RS17295	COG0582	viral genome integration into host DNA
ASR50_RS17350	COG2188	Transcriptional regulator
ASR50_RS17355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ASR50_RS17385	COG0277	FAD linked oxidase domain protein
ASR50_RS17390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ASR50_RS17400	COG1846	Transcriptional regulator
ASR50_RS17420	COG0745	RESPONSE REGULATOR receiver
ASR50_RS17425	COG2205	protein histidine kinase activity
ASR50_RS17435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ASR50_RS17440	COG0477	Major facilitator Superfamily
ASR50_RS17450	COG3467	pyridoxamine 5'-phosphate
ASR50_RS17460	COG2353	YceI-like domain
ASR50_RS17465	COG0477	Major facilitator Superfamily
ASR50_RS17480	COG1191	sigma factor activity
ASR50_RS17485	COG1191	sigma factor activity
ASR50_RS17515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASR50_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS17590	COG0151	Belongs to the GarS family
ASR50_RS17595	COG0501	Belongs to the peptidase M48B family
ASR50_RS17605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASR50_RS17615	COG2197	response regulator
ASR50_RS17650	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASR50_RS17655	COG0047	phosphoribosylformylglycinamidine synthase activity
ASR50_RS17660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASR50_RS17690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASR50_RS17700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASR50_RS17725	COG1643	Atp-dependent helicase
ASR50_RS17760	COG0513	Belongs to the DEAD box helicase family
ASR50_RS17775	COG3851	Histidine kinase
ASR50_RS17780	COG2197	response regulator
ASR50_RS17785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASR50_RS17785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASR50_RS17805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASR50_RS17810	COG0579	oxidoreductase
ASR50_RS17830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASR50_RS17845	COG1846	Transcriptional regulator
ASR50_RS17905	COG0739	heme binding
ASR50_RS17905	COG1196	nuclear chromosome segregation
ASR50_RS17905	COG0741	lytic transglycosylase activity
ASR50_RS17910	COG0671	phosphoesterase, PA-phosphatase related
ASR50_RS17915	COG0277	FAD linked oxidase domain protein
ASR50_RS17925	COG1937	Protein conserved in bacteria
ASR50_RS17935	COG0306	phosphate transporter
ASR50_RS17940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASR50_RS17960	COG0406	alpha-ribazole phosphatase activity
ASR50_RS17960	COG0494	nUDIX hydrolase
ASR50_RS17975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASR50_RS17985	COG1131	(ABC) transporter
ASR50_RS17990	COG1725	Transcriptional regulator
ASR50_RS18020	COG0456	acetyltransferase
ASR50_RS18025	COG0737	Belongs to the 5'-nucleotidase family
ASR50_RS18035	COG2205	protein histidine kinase activity
ASR50_RS18035	COG2972	Histidine kinase
ASR50_RS18040	COG0745	RESPONSE REGULATOR receiver
ASR50_RS18045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASR50_RS18050	COG1609	Transcriptional regulator
ASR50_RS18055	COG0745	RESPONSE REGULATOR receiver
ASR50_RS18085	COG2897	thiosulfate sulfurtransferase activity
ASR50_RS18105	COG3485	protocatechuate 3,4-dioxygenase
ASR50_RS18110	COG0735	belongs to the Fur family
ASR50_RS18115	COG0354	folic acid binding
ASR50_RS18120	COG1490	D-aminoacyl-tRNA deacylase activity
ASR50_RS18130	COG4552	Acetyltransferase involved in intracellular survival and related
ASR50_RS18165	COG2186	Transcriptional regulator
ASR50_RS18195	COG1653	transport
ASR50_RS18200	COG1175	transmembrane transport
ASR50_RS18205	COG0395	ABC-type sugar transport system, permease component
ASR50_RS18210	COG2318	DinB family
ASR50_RS18260	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS18285	COG4977	sequence-specific DNA binding
ASR50_RS18320	COG0588	phosphoglycerate mutase activity
ASR50_RS18335	COG5002	protein histidine kinase activity
ASR50_RS18350	COG1329	Transcriptional regulator
ASR50_RS18355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASR50_RS18360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ASR50_RS18365	COG0215	cysteine-tRNA ligase activity
ASR50_RS18380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASR50_RS18390	COG3842	ATPase activity
ASR50_RS18395	COG2378	regulation of single-species biofilm formation
ASR50_RS18475	COG1105	Belongs to the carbohydrate kinase PfkB family
ASR50_RS18505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ASR50_RS18510	COG0463	Glycosyl transferase, family 2
ASR50_RS18525	COG1278	Cold shock
ASR50_RS18530	COG0459	protein refolding
ASR50_RS18555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASR50_RS18560	COG1737	Transcriptional regulator
ASR50_RS18585	COG4257	antibiotic catabolic process
ASR50_RS18605	COG3973	AAA domain
ASR50_RS18640	COG1061	Type III restriction enzyme res subunit
ASR50_RS18665	COG1278	Cold shock
ASR50_RS18670	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ASR50_RS18675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASR50_RS18685	COG2814	Major facilitator Superfamily
ASR50_RS18730	COG0739	heme binding
ASR50_RS18745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASR50_RS18745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASR50_RS18750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASR50_RS18760	COG2252	PERMEase
ASR50_RS18790	COG0667	Aldo Keto reductase
ASR50_RS18820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ASR50_RS18830	COG2124	cytochrome p450
ASR50_RS18855	COG0277	FAD linked oxidase domain protein
ASR50_RS18855	COG0247	lactate metabolic process
ASR50_RS18885	COG5006	permease, DMT superfamily
ASR50_RS18910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASR50_RS18925	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS18945	COG0259	pyridoxamine-phosphate oxidase activity
ASR50_RS18960	COG4821	SIS domain
ASR50_RS18970	COG2945	thiolester hydrolase activity
ASR50_RS18970	COG0596	Alpha beta hydrolase
ASR50_RS19050	COG2271	Major facilitator Superfamily
ASR50_RS19055	COG2072	flavoprotein involved in K transport
ASR50_RS19065	COG0259	pyridoxamine-phosphate oxidase activity
ASR50_RS19085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASR50_RS19085	COG0515	serine threonine protein kinase
ASR50_RS19100	COG3903	Transcriptional regulator
ASR50_RS19100	COG3629	intracellular signal transduction
ASR50_RS19115	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASR50_RS19135	COG1686	Belongs to the peptidase S11 family
ASR50_RS19160	COG0386	Belongs to the glutathione peroxidase family
ASR50_RS19240	COG2801	Transposase and inactivated derivatives
ASR50_RS19270	COG1846	Transcriptional regulator
ASR50_RS19275	COG3384	dioxygenase
ASR50_RS19280	COG1247	-acetyltransferase
ASR50_RS19300	COG0477	Major facilitator Superfamily
ASR50_RS19305	COG1349	DNA-binding transcription factor activity
ASR50_RS19315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASR50_RS19315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASR50_RS19315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASR50_RS19330	COG1970	mechanosensitive ion channel activity
ASR50_RS19335	COG3191	aminopeptidase activity
ASR50_RS19345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ASR50_RS19360	COG3263	regulation of cellular component size
ASR50_RS19370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ASR50_RS19375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ASR50_RS19385	COG0315	cyclic pyranopterin monophosphate synthase activity
ASR50_RS19390	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASR50_RS19390	COG0315	cyclic pyranopterin monophosphate synthase activity
ASR50_RS19395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASR50_RS19415	COG0708	Exodeoxyribonuclease III
ASR50_RS19425	COG2072	flavoprotein involved in K transport
ASR50_RS19430	COG2267	carboxylic ester hydrolase activity
ASR50_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS19440	COG4946	Tricorn protease homolog
ASR50_RS19440	COG0793	Belongs to the peptidase S41A family
ASR50_RS19450	COG2409	Drug exporters of the RND superfamily
ASR50_RS19455	COG0442	prolyl-tRNA aminoacylation
ASR50_RS19480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASR50_RS19485	COG1122	ATPase activity
ASR50_RS19495	COG0310	cobalt ion transport
ASR50_RS19530	COG0084	hydrolase, TatD family'
ASR50_RS19540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASR50_RS19545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASR50_RS19550	COG0488	(ABC) transporter
ASR50_RS19590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASR50_RS19605	COG2197	response regulator
ASR50_RS19615	COG4106	trans-aconitate 2-methyltransferase activity
ASR50_RS19625	COG1309	transcriptional regulator
ASR50_RS19635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ASR50_RS19645	COG0193	aminoacyl-tRNA hydrolase activity
ASR50_RS19650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASR50_RS19655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASR50_RS19660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASR50_RS19675	COG4585	Histidine kinase
ASR50_RS19705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASR50_RS19715	COG1136	(ABC) transporter
ASR50_RS19720	COG0577	efflux transmembrane transporter activity
ASR50_RS19765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASR50_RS19775	COG2124	cytochrome p450
ASR50_RS19790	COG0148	phosphopyruvate hydratase activity
ASR50_RS19810	COG1252	NADH dehydrogenase
ASR50_RS19815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASR50_RS19820	COG1136	(ABC) transporter
ASR50_RS19820	COG0577	efflux transmembrane transporter activity
ASR50_RS19825	COG1136	(ABC) transporter
ASR50_RS19835	COG2197	response regulator
ASR50_RS19840	COG4585	Histidine kinase
ASR50_RS19890	COG0183	Belongs to the thiolase family
ASR50_RS19895	COG2755	lipolytic protein G-D-S-L family
ASR50_RS19910	COG1316	TRANSCRIPTIONal
ASR50_RS19930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ASR50_RS19940	COG0402	S-adenosylhomocysteine deaminase activity
ASR50_RS19945	COG1228	amidohydrolase
ASR50_RS19950	COG1191	sigma factor activity
ASR50_RS19955	COG1366	Belongs to the anti-sigma-factor antagonist family
ASR50_RS19965	COG3104	oligopeptide transport
ASR50_RS19970	COG0745	RESPONSE REGULATOR receiver
ASR50_RS19975	COG2205	protein histidine kinase activity
ASR50_RS20020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ASR50_RS20035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASR50_RS20045	COG1316	TRANSCRIPTIONal
ASR50_RS20070	COG1136	(ABC) transporter
ASR50_RS20075	COG0577	efflux transmembrane transporter activity
ASR50_RS20075	COG1136	(ABC) transporter
ASR50_RS20095	COG1316	TRANSCRIPTIONal
ASR50_RS20100	COG1316	TRANSCRIPTIONal
ASR50_RS20105	COG1316	TRANSCRIPTIONal
ASR50_RS20110	COG1316	TRANSCRIPTIONal
ASR50_RS20135	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ASR50_RS20135	COG0778	Nitroreductase
ASR50_RS20140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ASR50_RS20175	COG1620	l-lactate permease
ASR50_RS20180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASR50_RS20190	COG1482	cell wall glycoprotein biosynthetic process
ASR50_RS20200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ASR50_RS20235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASR50_RS20245	COG0123	including yeast histone deacetylase and acetoin utilization protein
ASR50_RS20290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ASR50_RS20295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASR50_RS20300	COG0181	hydroxymethylbilane synthase activity
ASR50_RS20305	COG1648	precorrin-2 dehydrogenase activity
ASR50_RS20305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASR50_RS20355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASR50_RS20380	COG0113	porphobilinogen synthase activity
ASR50_RS20400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASR50_RS20420	COG0018	arginyl-trna synthetase
ASR50_RS20425	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ASR50_RS20445	COG1690	Belongs to the RtcB family
ASR50_RS20450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ASR50_RS20465	COG1742	UPF0060 membrane protein
ASR50_RS20470	COG1846	Transcriptional regulator
ASR50_RS20475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS20490	COG2205	protein histidine kinase activity
ASR50_RS20495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASR50_RS20500	COG1116	anion transmembrane transporter activity
ASR50_RS20510	COG0659	secondary active sulfate transmembrane transporter activity
ASR50_RS20520	COG0596	Alpha beta hydrolase
ASR50_RS20540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASR50_RS20545	COG0406	alpha-ribazole phosphatase activity
ASR50_RS20555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASR50_RS20560	COG0785	Cytochrome C biogenesis protein
ASR50_RS20565	COG1333	cytochrome c biogenesis protein
ASR50_RS20570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASR50_RS20600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASR50_RS20605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASR50_RS20615	COG0163	prenyltransferase activity
ASR50_RS20625	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASR50_RS20630	COG1573	uracil-dna glycosylase
ASR50_RS20645	COG1301	dicarboxylic acid transport
ASR50_RS20660	COG1309	transcriptional regulator
ASR50_RS20670	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS20675	COG0183	Belongs to the thiolase family
ASR50_RS20690	COG1278	Cold shock
ASR50_RS20695	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ASR50_RS20790	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ASR50_RS20880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASR50_RS20890	COG3979	chitinase
ASR50_RS20895	COG2226	methyltransferase
ASR50_RS20930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASR50_RS20935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASR50_RS20940	COG0649	NAD binding
ASR50_RS20950	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ASR50_RS20955	COG1034	ATP synthesis coupled electron transport
ASR50_RS20960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASR50_RS20965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASR50_RS20970	COG0839	Belongs to the complex I subunit 6 family
ASR50_RS20975	COG0713	ATP synthesis coupled electron transport
ASR50_RS20980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASR50_RS20990	COG1007	ATP synthesis coupled electron transport
ASR50_RS21010	COG0561	phosphatase activity
ASR50_RS21020	COG0142	geranyltranstransferase activity
ASR50_RS21030	COG1131	(ABC) transporter
ASR50_RS21040	COG0655	NAD(P)H dehydrogenase (quinone) activity
ASR50_RS21070	COG0702	epimerase
ASR50_RS21075	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASR50_RS21080	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASR50_RS21080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASR50_RS21100	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASR50_RS21105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASR50_RS21110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASR50_RS21115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASR50_RS21120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASR50_RS21125	COG0839	Belongs to the complex I subunit 6 family
ASR50_RS21130	COG0713	ATP synthesis coupled electron transport
ASR50_RS21135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASR50_RS21145	COG1007	ATP synthesis coupled electron transport
ASR50_RS21150	COG0501	Belongs to the peptidase M48B family
ASR50_RS21155	COG3304	Inner membrane component domain
ASR50_RS21165	COG2261	transglycosylase associated protein
ASR50_RS21170	COG1666	GTP binding
ASR50_RS21190	COG0702	epimerase
ASR50_RS21210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASR50_RS21215	COG2030	dehydratase
ASR50_RS21225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASR50_RS21235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASR50_RS21240	COG0436	Aminotransferase
ASR50_RS21255	COG0250	Participates in transcription elongation, termination and antitermination
ASR50_RS21260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASR50_RS21265	COG0081	regulation of translation
ASR50_RS21280	COG0222	ribosome binding
ASR50_RS21285	COG0085	RNA polymerase activity
ASR50_RS21290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASR50_RS21300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ASR50_RS21305	COG0049	tRNA binding
ASR50_RS21310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASR50_RS21315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASR50_RS21325	COG0702	epimerase
ASR50_RS21335	COG0667	Aldo Keto reductase
ASR50_RS21370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASR50_RS21405	COG3209	COG3209 Rhs family protein
ASR50_RS21430	COG0051	transcription antitermination factor activity, RNA binding
ASR50_RS21435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASR50_RS21440	COG0088	Forms part of the polypeptide exit tunnel
ASR50_RS21445	COG0089	rRNA binding
ASR50_RS21450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASR50_RS21455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASR50_RS21460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASR50_RS21465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASR50_RS21470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASR50_RS21475	COG0255	Belongs to the universal ribosomal protein uL29 family
ASR50_RS21480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASR50_RS21485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASR50_RS21490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASR50_RS21495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASR50_RS21500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASR50_RS21505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASR50_RS21510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ASR50_RS21515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASR50_RS21520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASR50_RS21525	COG1841	ribosomal large subunit assembly
ASR50_RS21530	COG0200	Binds to the 23S rRNA
ASR50_RS21540	COG0563	adenylate kinase activity
ASR50_RS21550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASR50_RS21555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASR50_RS21560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASR50_RS21565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASR50_RS21570	COG0202	RNA polymerase activity
ASR50_RS21575	COG0203	ribosomal protein L17
ASR50_RS21580	COG0101	tRNA pseudouridine synthase activity
ASR50_RS21595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASR50_RS21600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASR50_RS21605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASR50_RS21610	COG1072	(Pantothenic acid kinase))
ASR50_RS21620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASR50_RS21625	COG0736	holo-[acyl-carrier-protein] synthase activity
ASR50_RS21630	COG1191	sigma factor activity
ASR50_RS21645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASR50_RS21655	COG0802	atpase or kinase
ASR50_RS21665	COG0456	acetyltransferase
ASR50_RS21665	COG1214	PFAM Peptidase M22, glycoprotease
ASR50_RS21675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASR50_RS21690	COG1316	TRANSCRIPTIONal
ASR50_RS21700	COG4941	Belongs to the sigma-70 factor family
ASR50_RS21710	COG0726	polysaccharide deacetylase
ASR50_RS21715	COG0726	polysaccharide deacetylase
ASR50_RS21720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASR50_RS21725	COG0459	protein refolding
ASR50_RS21780	COG4221	oxidoreductase activity
ASR50_RS21790	COG0583	DNA-binding transcription factor activity
ASR50_RS21805	COG1595	DNA-templated transcription, initiation
ASR50_RS21815	COG0516	GMP reductase activity
ASR50_RS21825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASR50_RS21840	COG0515	serine threonine protein kinase
ASR50_RS21845	COG0515	serine threonine protein kinase
ASR50_RS21850	COG0515	serine threonine protein kinase
ASR50_RS21855	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS21875	COG0519	Catalyzes the synthesis of GMP from XMP
ASR50_RS21875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASR50_RS21915	COG2197	response regulator
ASR50_RS21920	COG0791	NLP P60 protein
ASR50_RS21940	COG0739	heme binding
ASR50_RS21950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS21950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS21965	COG0714	Associated with various cellular activities
ASR50_RS21975	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ASR50_RS21985	COG0045	succinate-CoA ligase (ADP-forming) activity
ASR50_RS22015	COG0138	bifunctional purine biosynthesis protein purh
ASR50_RS22040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASR50_RS22055	COG0039	L-malate dehydrogenase activity
ASR50_RS22075	COG2801	Transposase and inactivated derivatives
ASR50_RS22075	COG3415	Transposase
ASR50_RS22080	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS22090	COG4175	Glycine betaine
ASR50_RS22090	COG0517	IMP dehydrogenase activity
ASR50_RS22095	COG4176	ABC-type proline glycine betaine transport system permease component
ASR50_RS22105	COG3415	Transposase
ASR50_RS22105	COG2801	Transposase and inactivated derivatives
ASR50_RS22110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ASR50_RS22115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASR50_RS22120	COG3415	Transposase
ASR50_RS22120	COG2801	Transposase and inactivated derivatives
ASR50_RS22130	COG0754	glutathionylspermidine amidase activity
ASR50_RS22135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASR50_RS22155	COG0180	Tryptophanyl-tRNA synthetase
ASR50_RS22175	COG0671	phosphoesterase, PA-phosphatase related
ASR50_RS22180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASR50_RS22195	COG1686	Belongs to the peptidase S11 family
ASR50_RS22205	COG1408	metallophosphoesterase
ASR50_RS22210	COG2205	protein histidine kinase activity
ASR50_RS22215	COG2409	Drug exporters of the RND superfamily
ASR50_RS22220	COG1309	transcriptional regulator
ASR50_RS22250	COG4585	Histidine kinase
ASR50_RS22260	COG1053	succinate dehydrogenase
ASR50_RS22270	COG2009	succinate dehydrogenase
ASR50_RS22325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS22325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS22350	COG1216	Glycosyl transferase, family 2
ASR50_RS22365	COG1216	Glycosyl transferase, family 2
ASR50_RS22385	COG2089	acid synthase
ASR50_RS22395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ASR50_RS22395	COG1473	amidohydrolase
ASR50_RS22400	COG1744	ABC transporter substrate-binding protein PnrA-like
ASR50_RS22405	COG1744	ABC transporter substrate-binding protein PnrA-like
ASR50_RS22410	COG3845	ABC transporter
ASR50_RS22415	COG4603	Belongs to the binding-protein-dependent transport system permease family
ASR50_RS22420	COG1079	Belongs to the binding-protein-dependent transport system permease family
ASR50_RS22450	COG2814	Major facilitator Superfamily
ASR50_RS22455	COG0583	DNA-binding transcription factor activity
ASR50_RS22465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASR50_RS22490	COG2205	protein histidine kinase activity
ASR50_RS22495	COG0745	RESPONSE REGULATOR receiver
ASR50_RS22500	COG1595	DNA-templated transcription, initiation
ASR50_RS22515	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS22520	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS22525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASR50_RS22535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASR50_RS22560	COG4770	biotin carboxylase activity
ASR50_RS22570	COG0424	maF-like protein
ASR50_RS22580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASR50_RS22590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ASR50_RS22595	COG1024	Enoyl-CoA hydratase
ASR50_RS22605	COG2986	histidine ammonia-lyase
ASR50_RS22625	COG1404	Belongs to the peptidase S8 family
ASR50_RS22635	COG1064	alcohol dehydrogenase
ASR50_RS22645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASR50_RS22645	COG0515	serine threonine protein kinase
ASR50_RS22670	COG2255	four-way junction helicase activity
ASR50_RS22675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASR50_RS22690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASR50_RS22700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ASR50_RS22715	COG1331	Highly conserved protein containing a thioredoxin domain
ASR50_RS22725	COG1309	transcriptional regulator
ASR50_RS22735	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ASR50_RS22780	COG0436	Aminotransferase
ASR50_RS22790	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ASR50_RS22805	COG1414	Transcriptional regulator
ASR50_RS22810	COG0251	oxidation-reduction process
ASR50_RS22815	COG2610	gluconate transmembrane transporter activity
ASR50_RS22850	COG2894	cell division
ASR50_RS22885	COG2197	response regulator
ASR50_RS22905	COG2885	chlorophyll binding
ASR50_RS22935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS22945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASR50_RS22950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASR50_RS22965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ASR50_RS22970	COG0450	alkyl hydroperoxide reductase
ASR50_RS22985	COG1136	(ABC) transporter
ASR50_RS23005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASR50_RS23020	COG0114	fumarate hydratase activity
ASR50_RS23030	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ASR50_RS23030	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ASR50_RS23055	COG0778	Nitroreductase
ASR50_RS23060	COG1722	exodeoxyribonuclease VII activity
ASR50_RS23065	COG1570	exodeoxyribonuclease VII activity
ASR50_RS23070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASR50_RS23080	COG0012	GTP binding
ASR50_RS23140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASR50_RS23145	COG1053	succinate dehydrogenase
ASR50_RS23160	COG0747	negative chemotaxis
ASR50_RS23165	COG1217	gtp-binding protein TYPA
ASR50_RS23170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASR50_RS23175	COG0747	negative chemotaxis
ASR50_RS23180	COG0601	transmembrane transport
ASR50_RS23185	COG0444	Belongs to the ABC transporter superfamily
ASR50_RS23190	COG4608	Belongs to the ABC transporter superfamily
ASR50_RS23200	COG0601	transmembrane transport
ASR50_RS23205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASR50_RS23215	COG4608	Belongs to the ABC transporter superfamily
ASR50_RS23230	COG0154	amidase activity
ASR50_RS23270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ASR50_RS23285	COG1131	(ABC) transporter
ASR50_RS23295	COG4585	Histidine kinase
ASR50_RS23300	COG2197	response regulator
ASR50_RS23335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASR50_RS23360	COG2818	Glycosylase
ASR50_RS23365	COG1024	Enoyl-CoA hydratase
ASR50_RS23375	COG1595	DNA-templated transcription, initiation
ASR50_RS23385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASR50_RS23390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASR50_RS23435	COG0598	Magnesium transport protein CorA
ASR50_RS23445	COG2814	Major facilitator Superfamily
ASR50_RS23455	COG0613	PHP domain protein
ASR50_RS23460	COG2095	MarC family integral membrane protein
ASR50_RS23465	COG1432	Conserved Protein
ASR50_RS23480	COG0513	Belongs to the DEAD box helicase family
ASR50_RS23545	COG0596	Alpha beta hydrolase
ASR50_RS23570	COG0210	DNA helicase
ASR50_RS23575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASR50_RS23580	COG2816	NAD+ diphosphatase activity
ASR50_RS23610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASR50_RS23660	COG3480	Lon protease (S16) C-terminal proteolytic domain
ASR50_RS23670	COG1615	UPF0182 protein
ASR50_RS23695	COG0753	catalase activity
ASR50_RS23750	COG0483	inositol monophosphate 1-phosphatase activity
ASR50_RS23760	COG2076	Multidrug Resistance protein
ASR50_RS23765	COG1162	GTPase activity
ASR50_RS23770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ASR50_RS23780	COG2135	peptidase activity
ASR50_RS23790	COG1595	DNA-templated transcription, initiation
ASR50_RS23795	COG5662	AntiSigma factor
ASR50_RS23800	COG2199	diguanylate cyclase activity
ASR50_RS23800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ASR50_RS23815	COG0242	peptide deformylase activity
ASR50_RS23825	COG2124	cytochrome p450
ASR50_RS23865	COG2188	Transcriptional regulator
ASR50_RS23870	COG0363	glucosamine-6-phosphate deaminase activity
ASR50_RS23885	COG1597	lipid kinase activity
ASR50_RS23925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASR50_RS23930	COG0142	geranyltranstransferase activity
ASR50_RS23935	COG0456	acetyltransferase
ASR50_RS23945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ASR50_RS23975	COG4106	trans-aconitate 2-methyltransferase activity
ASR50_RS23980	COG1126	abc transporter atp-binding protein
ASR50_RS23985	COG0765	amino acid transport
ASR50_RS23995	COG0281	malic enzyme
ASR50_RS24000	COG0604	alcohol dehydrogenase
ASR50_RS24030	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASR50_RS24030	COG0567	Dehydrogenase, E1 component
ASR50_RS24035	COG2205	protein histidine kinase activity
ASR50_RS24040	COG0745	RESPONSE REGULATOR receiver
ASR50_RS24050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ASR50_RS24095	COG3883	PFAM NLP P60 protein
ASR50_RS24095	COG0791	NLP P60 protein
ASR50_RS24105	COG1309	transcriptional regulator
ASR50_RS24120	COG0768	penicillin binding
ASR50_RS24145	COG1793	dna ligase
ASR50_RS24145	COG3285	dna ligase
ASR50_RS24150	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ASR50_RS24155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASR50_RS24160	COG1595	DNA-templated transcription, initiation
ASR50_RS24170	COG2197	response regulator
ASR50_RS24175	COG4585	Histidine kinase
ASR50_RS24185	COG0395	ABC-type sugar transport system, permease component
ASR50_RS24190	COG4209	transmembrane transport
ASR50_RS24195	COG1653	transport
ASR50_RS24225	COG0745	RESPONSE REGULATOR receiver
ASR50_RS24230	COG0018	arginyl-trna synthetase
ASR50_RS24230	COG0018	arginyl-trna synthetase
ASR50_RS24235	COG0019	diaminopimelate decarboxylase activity
ASR50_RS24240	COG0460	homoserine dehydrogenase
ASR50_RS24245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASR50_RS24250	COG0083	homoserine kinase activity
ASR50_RS24265	COG0254	rRNA binding
ASR50_RS24270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASR50_RS24275	COG2890	protein-(glutamine-N5) methyltransferase activity
ASR50_RS24285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASR50_RS24290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASR50_RS24295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASR50_RS24310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASR50_RS24315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASR50_RS24320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASR50_RS24325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASR50_RS24330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASR50_RS24335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASR50_RS24340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASR50_RS24355	COG2197	response regulator
ASR50_RS24360	COG4585	Histidine kinase
ASR50_RS24385	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASR50_RS24400	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ASR50_RS24420	COG3415	Transposase
ASR50_RS24420	COG2801	Transposase and inactivated derivatives
ASR50_RS24440	COG1131	(ABC) transporter
ASR50_RS24460	COG0183	Belongs to the thiolase family
ASR50_RS24525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS24525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS24565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ASR50_RS24570	COG0857	belongs to the CobB CobQ family
ASR50_RS24570	COG0280	phosphate acetyltransferase
ASR50_RS24575	COG0205	6-phosphofructokinase activity
ASR50_RS24585	COG3833	ABC-type maltose transport systems, permease component
ASR50_RS24590	COG4565	transcriptional regulatory protein
ASR50_RS24595	COG3290	protein histidine kinase activity
ASR50_RS24600	COG1301	dicarboxylic acid transport
ASR50_RS24610	COG3118	belongs to the thioredoxin family
ASR50_RS24620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ASR50_RS24625	COG3281	Trehalose synthase
ASR50_RS24635	COG0366	Alpha amylase catalytic
ASR50_RS24640	COG0058	SHG alpha-glucan phosphorylase activity
ASR50_RS24660	COG1132	(ABC) transporter
ASR50_RS24670	COG1132	(ABC) transporter
ASR50_RS24680	COG1132	(ABC) transporter
ASR50_RS24685	COG1132	(ABC) transporter
ASR50_RS24690	COG1131	(ABC) transporter
ASR50_RS24700	COG4585	Histidine kinase
ASR50_RS24705	COG2197	response regulator
ASR50_RS24735	COG0789	Transcriptional regulator
ASR50_RS24745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASR50_RS24750	COG3409	Peptidoglycan-binding domain 1 protein
ASR50_RS24750	COG3757	hydrolase, family 25
ASR50_RS24755	COG1760	l-serine dehydratase
ASR50_RS24760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASR50_RS24765	COG0509	glycine decarboxylation via glycine cleavage system
ASR50_RS24770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASR50_RS24790	COG0747	negative chemotaxis
ASR50_RS24795	COG0601	transmembrane transport
ASR50_RS24800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASR50_RS24805	COG0444	Belongs to the ABC transporter superfamily
ASR50_RS24810	COG4608	Belongs to the ABC transporter superfamily
ASR50_RS24815	COG2860	membrane
ASR50_RS24845	COG0482	sulfurtransferase activity
ASR50_RS24860	COG1611	Belongs to the LOG family
ASR50_RS24865	COG4221	oxidoreductase activity
ASR50_RS24875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASR50_RS24885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASR50_RS24890	COG0154	amidase activity
ASR50_RS24900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASR50_RS24905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASR50_RS24915	COG2409	Drug exporters of the RND superfamily
ASR50_RS24920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASR50_RS24935	COG2197	response regulator
ASR50_RS24945	COG2133	pyrroloquinoline quinone binding
ASR50_RS24950	COG0667	Aldo Keto reductase
ASR50_RS24960	COG5001	Diguanylate cyclase
ASR50_RS24970	COG0440	acetolactate synthase activity
ASR50_RS24975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASR50_RS24980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASR50_RS24995	COG3835	regulator
ASR50_RS25000	COG0506	proline dehydrogenase activity
ASR50_RS25005	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS25010	COG0473	3-isopropylmalate dehydrogenase activity
ASR50_RS25015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASR50_RS25025	COG0832	Belongs to the urease beta subunit family
ASR50_RS25025	COG0831	urea catabolic process
ASR50_RS25030	COG0804	urea catabolic process
ASR50_RS25035	COG2957	Belongs to the agmatine deiminase family
ASR50_RS25050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASR50_RS25060	COG2353	YceI-like domain
ASR50_RS25065	COG1032	radical SAM domain protein
ASR50_RS25070	COG0300	oxidoreductase activity
ASR50_RS25075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASR50_RS25095	COG2018	Roadblock/LC7 domain
ASR50_RS25115	COG2018	Roadblock/LC7 domain
ASR50_RS25120	COG5002	protein histidine kinase activity
ASR50_RS25130	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASR50_RS25135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASR50_RS25170	COG0789	Transcriptional regulator
ASR50_RS25180	COG1414	Transcriptional regulator
ASR50_RS25185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASR50_RS25190	COG0066	3-isopropylmalate dehydratase activity
ASR50_RS25200	COG0776	regulation of translation
ASR50_RS25210	COG1920	GTP binding
ASR50_RS25220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASR50_RS25225	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASR50_RS25245	COG0351	phosphomethylpyrimidine kinase
ASR50_RS25250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASR50_RS25255	COG1461	Dihydroxyacetone kinase
ASR50_RS25265	COG0742	ribosomal rna small subunit methyltransferase
ASR50_RS25270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASR50_RS25285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASR50_RS25290	COG0571	ribonuclease III activity
ASR50_RS25295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASR50_RS25300	COG1733	regulation of RNA biosynthetic process
ASR50_RS25315	COG2340	Cysteine-rich secretory protein family
ASR50_RS25320	COG1254	Belongs to the acylphosphatase family
ASR50_RS25330	COG1196	nuclear chromosome segregation
ASR50_RS25335	COG0477	Major facilitator Superfamily
ASR50_RS25365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ASR50_RS25375	COG4106	trans-aconitate 2-methyltransferase activity
ASR50_RS25385	COG0228	four-way junction DNA binding
ASR50_RS25390	COG1837	Belongs to the UPF0109 family
ASR50_RS25395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASR50_RS25400	COG0336	Belongs to the RNA methyltransferase TrmD family
ASR50_RS25405	COG0335	large ribosomal subunit rRNA binding
ASR50_RS25410	COG0681	Belongs to the peptidase S26 family
ASR50_RS25420	COG0681	Belongs to the peptidase S26 family
ASR50_RS25440	COG0792	nuclease activity
ASR50_RS25455	COG1191	sigma factor activity
ASR50_RS25465	COG4942	peptidase
ASR50_RS25470	COG0052	Belongs to the universal ribosomal protein uS2 family
ASR50_RS25475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASR50_RS25480	COG0528	UMP kinase activity
ASR50_RS25485	COG0233	cytoplasmic translational termination
ASR50_RS25505	COG0442	prolyl-tRNA aminoacylation
ASR50_RS25510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ASR50_RS25520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ASR50_RS25525	COG3842	ATPase activity
ASR50_RS25550	COG1136	(ABC) transporter
ASR50_RS25555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASR50_RS25565	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS25580	COG0584	glycerophosphoryl diester phosphodiesterase
ASR50_RS25585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASR50_RS25600	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS25610	COG3842	ATPase activity
ASR50_RS25615	COG1176	ABC-type spermidine putrescine transport system, permease component I
ASR50_RS25620	COG1177	transmembrane transport
ASR50_RS25625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASR50_RS25640	COG1401	restriction endodeoxyribonuclease activity
ASR50_RS25660	COG2508	Transcriptional regulator
ASR50_RS25665	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS25670	COG1472	Belongs to the glycosyl hydrolase 3 family
ASR50_RS25680	COG4209	transmembrane transport
ASR50_RS25685	COG0395	ABC-type sugar transport system, permease component
ASR50_RS25715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASR50_RS25720	COG0750	zinc metalloprotease
ASR50_RS25725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASR50_RS25740	COG0442	prolyl-tRNA aminoacylation
ASR50_RS25785	COG0779	Required for maturation of 30S ribosomal subunits
ASR50_RS25795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASR50_RS25805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASR50_RS25810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ASR50_RS25830	COG4608	Belongs to the ABC transporter superfamily
ASR50_RS25835	COG0444	Belongs to the ABC transporter superfamily
ASR50_RS25840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASR50_RS25845	COG0601	transmembrane transport
ASR50_RS25850	COG0747	negative chemotaxis
ASR50_RS25855	COG0455	bacterial-type flagellum organization
ASR50_RS25875	COG1404	Belongs to the peptidase S8 family
ASR50_RS25890	COG1404	Belongs to the peptidase S8 family
ASR50_RS25920	COG1674	ftsk spoiiie
ASR50_RS25935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASR50_RS25940	COG1185	polyribonucleotide nucleotidyltransferase activity
ASR50_RS25945	COG0612	Peptidase, M16
ASR50_RS25950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASR50_RS25965	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ASR50_RS25970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASR50_RS25975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ASR50_RS26010	COG2770	Histidine kinase
ASR50_RS26010	COG2208	phosphoserine phosphatase activity
ASR50_RS26015	COG3850	Histidine kinase
ASR50_RS26015	COG3437	response regulator, receiver
ASR50_RS26015	COG2205	protein histidine kinase activity
ASR50_RS26015	COG4999	Histidine kinase
ASR50_RS26025	COG1674	ftsk spoiiie
ASR50_RS26035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASR50_RS26045	COG1058	Belongs to the CinA family
ASR50_RS26045	COG1546	Belongs to the CinA family
ASR50_RS26050	COG1396	sequence-specific DNA binding
ASR50_RS26055	COG0783	Belongs to the Dps family
ASR50_RS26065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASR50_RS26070	COG1201	RNA secondary structure unwinding
ASR50_RS26095	COG0628	permease
ASR50_RS26110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASR50_RS26125	COG0765	amino acid transport
ASR50_RS26130	COG0765	amino acid transport
ASR50_RS26135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASR50_RS26140	COG1126	abc transporter atp-binding protein
ASR50_RS26145	COG0745	RESPONSE REGULATOR receiver
ASR50_RS26150	COG2205	protein histidine kinase activity
ASR50_RS26155	COG2358	TRAP transporter, solute receptor (TAXI family
ASR50_RS26165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASR50_RS26185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASR50_RS26195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ASR50_RS26200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASR50_RS26210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASR50_RS26230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ASR50_RS26235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASR50_RS26240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASR50_RS26255	COG0588	phosphoglycerate mutase activity
ASR50_RS26275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASR50_RS26305	COG1129	ABC transporter
ASR50_RS26310	COG1802	Transcriptional regulator
ASR50_RS26315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASR50_RS26330	COG0187	DNA topoisomerase II activity
ASR50_RS26340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASR50_RS26345	COG4565	transcriptional regulatory protein
ASR50_RS26350	COG3290	protein histidine kinase activity
ASR50_RS26375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASR50_RS26380	COG0612	Peptidase, M16
ASR50_RS26395	COG1802	Transcriptional regulator
ASR50_RS26400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASR50_RS26420	COG1435	thymidine kinase activity
ASR50_RS26435	COG0666	response to abiotic stimulus
ASR50_RS26445	COG3864	Putative metallopeptidase domain
ASR50_RS26455	COG1733	regulation of RNA biosynthetic process
ASR50_RS26500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASR50_RS26510	COG0745	RESPONSE REGULATOR receiver
ASR50_RS26515	COG2205	protein histidine kinase activity
ASR50_RS26540	COG0756	dUTP diphosphatase activity
ASR50_RS26555	COG1136	(ABC) transporter
ASR50_RS26555	COG0577	efflux transmembrane transporter activity
ASR50_RS26585	COG0569	domain protein
ASR50_RS26590	COG0531	amino acid
ASR50_RS26595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASR50_RS26615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASR50_RS26615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASR50_RS26640	COG4585	Histidine kinase
ASR50_RS26645	COG1136	(ABC) transporter
ASR50_RS26645	COG0577	efflux transmembrane transporter activity
ASR50_RS26660	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS26695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ASR50_RS26705	COG2091	lysine biosynthetic process via aminoadipic acid
ASR50_RS26710	COG3903	Transcriptional regulator
ASR50_RS26710	COG3629	intracellular signal transduction
ASR50_RS26730	COG0463	Glycosyl transferase, family 2
ASR50_RS26730	COG1216	Glycosyl transferase, family 2
ASR50_RS26740	COG0789	Transcriptional regulator
ASR50_RS26765	COG0726	polysaccharide deacetylase
ASR50_RS26820	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS26835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASR50_RS26840	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ASR50_RS26850	COG1215	transferase activity, transferring glycosyl groups
ASR50_RS26860	COG4310	Domain of unknown function (DUF2172)
ASR50_RS26875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ASR50_RS26910	COG0367	asparagine synthase
ASR50_RS26930	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ASR50_RS26935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASR50_RS26940	COG3209	COG3209 Rhs family protein
ASR50_RS26950	COG2188	Transcriptional regulator
ASR50_RS26955	COG2182	Extracellular solute-binding protein
ASR50_RS26960	COG1175	transmembrane transport
ASR50_RS26965	COG0395	ABC-type sugar transport system, permease component
ASR50_RS26970	COG1472	Belongs to the glycosyl hydrolase 3 family
ASR50_RS26980	COG1799	cell septum assembly
ASR50_RS27015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASR50_RS27020	COG2235	arginine
ASR50_RS27025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASR50_RS27035	COG1024	Enoyl-CoA hydratase
ASR50_RS27095	COG2255	four-way junction helicase activity
ASR50_RS27100	COG2755	lipolytic protein G-D-S-L family
ASR50_RS27110	COG0738	Major facilitator superfamily
ASR50_RS27115	COG3415	Transposase
ASR50_RS27115	COG2801	Transposase and inactivated derivatives
ASR50_RS27120	COG1122	ATPase activity
ASR50_RS27130	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
ASR50_RS27135	COG0310	cobalt ion transport
ASR50_RS27145	COG0601	transmembrane transport
ASR50_RS27150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASR50_RS27160	COG0444	Belongs to the ABC transporter superfamily
ASR50_RS27165	COG1124	(ABC) transporter
ASR50_RS27215	COG4221	oxidoreductase activity
ASR50_RS27230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASR50_RS27240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASR50_RS27255	COG4209	transmembrane transport
ASR50_RS27260	COG0395	ABC-type sugar transport system, permease component
ASR50_RS27290	COG1653	transport
ASR50_RS27295	COG1175	transmembrane transport
ASR50_RS27300	COG0395	ABC-type sugar transport system, permease component
ASR50_RS27305	COG1940	carbohydrate kinase activity
ASR50_RS27310	COG4213	ABC transporter substrate-binding protein
ASR50_RS27320	COG4214	carbohydrate transport
ASR50_RS27325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASR50_RS27330	COG0531	amino acid
ASR50_RS27350	COG1316	TRANSCRIPTIONal
ASR50_RS27355	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS27360	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS27365	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS27370	COG0438	transferase activity, transferring glycosyl groups
ASR50_RS27380	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASR50_RS27380	COG1024	Enoyl-CoA hydratase
ASR50_RS27385	COG0183	Belongs to the thiolase family
ASR50_RS27395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASR50_RS27400	COG0569	domain protein
ASR50_RS27420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASR50_RS27430	COG1175	transmembrane transport
ASR50_RS27435	COG0395	ABC-type sugar transport system, permease component
ASR50_RS27450	COG3507	Belongs to the glycosyl hydrolase 43 family
ASR50_RS27465	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASR50_RS27475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ASR50_RS27480	COG3253	May function as heme-dependent peroxidase
ASR50_RS27500	COG3220	belongs to the UPF0276 family
ASR50_RS27510	COG0596	Alpha beta hydrolase
ASR50_RS27535	COG0723	plastoquinol--plastocyanin reductase activity
ASR50_RS27535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASR50_RS27565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASR50_RS27570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASR50_RS27600	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS27605	COG0477	Major facilitator Superfamily
ASR50_RS27610	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS27620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ASR50_RS27645	COG0745	RESPONSE REGULATOR receiver
ASR50_RS27650	COG5002	protein histidine kinase activity
ASR50_RS27660	COG2205	protein histidine kinase activity
ASR50_RS27665	COG0745	RESPONSE REGULATOR receiver
ASR50_RS27675	COG1174	glycine betaine transport
ASR50_RS27680	COG1174	glycine betaine transport
ASR50_RS27835	COG1116	anion transmembrane transporter activity
ASR50_RS27835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ASR50_RS27855	COG0529	Catalyzes the synthesis of activated sulfate
ASR50_RS27860	COG0175	sulfate reduction
ASR50_RS27890	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS27905	COG4977	sequence-specific DNA binding
ASR50_RS27905	COG1917	Cupin 2, conserved barrel domain protein
ASR50_RS27925	COG0583	DNA-binding transcription factor activity
ASR50_RS27965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ASR50_RS27970	COG2040	homocysteine
ASR50_RS28005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASR50_RS28020	COG0277	FAD linked oxidase domain protein
ASR50_RS28080	COG3293	Transposase
ASR50_RS28100	COG0596	Alpha beta hydrolase
ASR50_RS28105	COG2814	Major facilitator Superfamily
ASR50_RS28120	COG0488	(ABC) transporter
ASR50_RS28130	COG1051	belongs to the nudix hydrolase family
ASR50_RS28145	COG1162	GTPase activity
ASR50_RS28185	COG0028	Belongs to the TPP enzyme family
ASR50_RS28215	COG1802	Transcriptional regulator
ASR50_RS28225	COG3835	regulator
ASR50_RS28240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ASR50_RS28245	COG2252	PERMEase
ASR50_RS28270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASR50_RS28285	COG0859	PFAM glycosyl transferase family 9
ASR50_RS28320	COG4133	protoheme IX ABC transporter activity
ASR50_RS28325	COG2197	response regulator
ASR50_RS28330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASR50_RS28335	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS28340	COG0583	DNA-binding transcription factor activity
ASR50_RS28345	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS28355	COG3960	tartronate-semialdehyde synthase activity
ASR50_RS28370	COG2084	Dehydrogenase
ASR50_RS28375	COG3622	Belongs to the hyi family
ASR50_RS28395	COG2351	hydroxyisourate hydrolase activity
ASR50_RS28410	COG2233	PERMEase
ASR50_RS28430	COG1733	regulation of RNA biosynthetic process
ASR50_RS28490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASR50_RS28495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASR50_RS28505	COG0483	inositol monophosphate 1-phosphatase activity
ASR50_RS28515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASR50_RS28540	COG0789	Transcriptional regulator
ASR50_RS28560	COG0436	Aminotransferase
ASR50_RS28565	COG1733	regulation of RNA biosynthetic process
ASR50_RS28585	COG2304	oxidoreductase activity
ASR50_RS28590	COG4264	IucA IucC family
ASR50_RS28620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASR50_RS28635	COG1414	Transcriptional regulator
ASR50_RS28640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASR50_RS28645	COG4266	Belongs to the allantoicase family
ASR50_RS28650	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS28685	COG2188	Transcriptional regulator
ASR50_RS28690	COG1940	carbohydrate kinase activity
ASR50_RS28750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ASR50_RS28755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASR50_RS28760	COG0708	Exodeoxyribonuclease III
ASR50_RS28775	COG0405	Gamma-glutamyltransferase
ASR50_RS28810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASR50_RS28825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASR50_RS28835	COG1953	Uracil, thiamine, allantoin
ASR50_RS28850	COG0095	Lipoate-protein ligase
ASR50_RS28860	COG2226	methyltransferase
ASR50_RS28865	COG4608	Belongs to the ABC transporter superfamily
ASR50_RS28870	COG0444	Belongs to the ABC transporter superfamily
ASR50_RS28880	COG0747	negative chemotaxis
ASR50_RS28890	COG3458	cephalosporin-C deacetylase activity
ASR50_RS28900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASR50_RS28910	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ASR50_RS28935	COG0483	inositol monophosphate 1-phosphatase activity
ASR50_RS28945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ASR50_RS28960	COG3263	regulation of cellular component size
ASR50_RS28985	COG3415	Transposase
ASR50_RS28985	COG2801	Transposase and inactivated derivatives
ASR50_RS28990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASR50_RS29005	COG1929	Belongs to the glycerate kinase type-1 family
ASR50_RS29015	COG0688	phosphatidylethanolamine metabolic process
ASR50_RS29020	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS29035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS29035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASR50_RS29040	COG0604	alcohol dehydrogenase
ASR50_RS29050	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASR50_RS29115	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS29120	COG2362	D-Aminopeptidase
ASR50_RS29125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASR50_RS29135	COG1619	proteins homologs of microcin C7 resistance protein MccF
ASR50_RS29140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASR50_RS29165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ASR50_RS29225	COG2226	methyltransferase
ASR50_RS29230	COG0488	(ABC) transporter
ASR50_RS29240	COG0693	protein deglycase activity
ASR50_RS29245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASR50_RS29245	COG0517	IMP dehydrogenase activity
ASR50_RS29315	COG0443	Heat shock 70 kDa protein
ASR50_RS29335	COG2154	pterin-4-alpha-carbinolamine dehydratase
ASR50_RS29340	COG2226	methyltransferase
ASR50_RS29345	COG3340	Belongs to the peptidase S51 family
ASR50_RS29350	COG3896	Chloramphenicol phosphotransferase-like protein
ASR50_RS29360	COG5297	Belongs to the glycosyl hydrolase family 6
ASR50_RS29360	COG4733	cellulase activity
ASR50_RS29365	COG5297	Belongs to the glycosyl hydrolase family 6
ASR50_RS29370	COG4106	trans-aconitate 2-methyltransferase activity
ASR50_RS29375	COG4221	oxidoreductase activity
ASR50_RS29380	COG0656	L-ascorbic acid biosynthetic process
ASR50_RS29390	COG0583	DNA-binding transcription factor activity
ASR50_RS29405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASR50_RS29420	COG3383	formate dehydrogenase (NAD+) activity
ASR50_RS29425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASR50_RS29435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASR50_RS29445	COG1940	carbohydrate kinase activity
ASR50_RS29455	COG1129	ABC transporter
ASR50_RS29460	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASR50_RS29470	COG0673	inositol 2-dehydrogenase activity
ASR50_RS29490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASR50_RS29525	COG2223	nitrite transmembrane transporter activity
ASR50_RS29535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS29545	COG0045	succinate-CoA ligase (ADP-forming) activity
ASR50_RS29555	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS29585	COG0477	Major facilitator Superfamily
ASR50_RS29590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASR50_RS29600	COG2182	Extracellular solute-binding protein
ASR50_RS29605	COG1175	transmembrane transport
ASR50_RS29610	COG0395	ABC-type sugar transport system, permease component
ASR50_RS29615	COG2723	6-phospho-beta-galactosidase activity
ASR50_RS29625	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS29640	COG2318	DinB family
ASR50_RS29660	COG0714	Associated with various cellular activities
ASR50_RS29665	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ASR50_RS29690	COG0789	Transcriptional regulator
ASR50_RS29730	COG0210	DNA helicase
ASR50_RS29805	COG0515	serine threonine protein kinase
ASR50_RS29805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASR50_RS29815	COG1846	Transcriptional regulator
ASR50_RS29855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASR50_RS29870	COG1012	belongs to the aldehyde dehydrogenase family
ASR50_RS29880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ASR50_RS29910	COG0297	glycogen (starch) synthase activity
ASR50_RS29930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASR50_RS29940	COG3467	pyridoxamine 5'-phosphate
ASR50_RS29945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASR50_RS29950	COG0406	alpha-ribazole phosphatase activity
ASR50_RS29955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ASR50_RS29960	COG0166	Belongs to the GPI family
ASR50_RS29990	COG2409	Drug exporters of the RND superfamily
ASR50_RS29995	COG2197	response regulator
ASR50_RS30000	COG4585	Histidine kinase
ASR50_RS30005	COG1486	melibiose metabolic process
ASR50_RS30015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ASR50_RS30065	COG3938	Belongs to the proline racemase family
ASR50_RS30080	COG1653	transport
ASR50_RS30085	COG1175	transmembrane transport
ASR50_RS30090	COG0395	ABC-type sugar transport system, permease component
ASR50_RS30095	COG0366	Alpha amylase catalytic
ASR50_RS30105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASR50_RS30135	COG0745	RESPONSE REGULATOR receiver
ASR50_RS30145	COG0435	Glutathione S-transferase
ASR50_RS30175	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ASR50_RS30175	COG1672	PFAM Archaeal ATPase
ASR50_RS30180	COG0477	Major facilitator Superfamily
ASR50_RS30185	COG3415	Transposase
ASR50_RS30185	COG2801	Transposase and inactivated derivatives
ASR50_RS30190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ASR50_RS30195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASR50_RS30200	COG3485	protocatechuate 3,4-dioxygenase
ASR50_RS30205	COG3485	protocatechuate 3,4-dioxygenase
ASR50_RS30215	COG1470	cell adhesion involved in biofilm formation
ASR50_RS30225	COG1793	dna ligase
ASR50_RS30270	COG1834	amidinotransferase
ASR50_RS30275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASR50_RS30280	COG0488	(ABC) transporter
ASR50_RS30305	COG1515	deoxyribonuclease V activity
ASR50_RS30310	COG3268	Saccharopine dehydrogenase
ASR50_RS30320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS30325	COG0183	Belongs to the thiolase family
ASR50_RS30330	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASR50_RS30330	COG1024	Enoyl-CoA hydratase
ASR50_RS30340	COG1113	amino acid transport
ASR50_RS30350	COG2936	dipeptidyl-peptidase activity
ASR50_RS30360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ASR50_RS30375	COG0488	(ABC) transporter
ASR50_RS30385	COG2183	response to ionizing radiation
ASR50_RS30390	COG1024	Enoyl-CoA hydratase
ASR50_RS30405	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ASR50_RS30450	COG1134	teichoic acid transport
ASR50_RS30450	COG1388	LysM domain
ASR50_RS30455	COG1562	ergosterol biosynthetic process
ASR50_RS30465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ASR50_RS30475	COG1657	PFAM Prenyltransferase squalene oxidase
ASR50_RS30490	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASR50_RS30495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASR50_RS30515	COG2365	Tyrosine phosphatase family
ASR50_RS30525	COG2755	lipolytic protein G-D-S-L family
ASR50_RS30545	COG2814	Major facilitator Superfamily
ASR50_RS30545	COG0477	Major facilitator Superfamily
ASR50_RS30560	COG2159	amidohydrolase
ASR50_RS30565	COG2828	Protein conserved in bacteria
ASR50_RS30600	COG1063	alcohol dehydrogenase
ASR50_RS30605	COG0156	8-amino-7-oxononanoate synthase activity
ASR50_RS30615	COG1309	transcriptional regulator
ASR50_RS30620	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS30640	COG3958	Transketolase
ASR50_RS30645	COG3959	Transketolase, thiamine diphosphate binding domain
ASR50_RS30705	COG0183	Belongs to the thiolase family
ASR50_RS30745	COG2188	Transcriptional regulator
ASR50_RS30750	COG3962	Belongs to the TPP enzyme family
ASR50_RS30755	COG3718	enzyme involved in inositol metabolism
ASR50_RS30765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASR50_RS30790	COG0673	inositol 2-dehydrogenase activity
ASR50_RS30820	COG0673	inositol 2-dehydrogenase activity
ASR50_RS30825	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS30835	COG1609	Transcriptional regulator
ASR50_RS30840	COG3548	integral membrane protein
ASR50_RS30845	COG0673	inositol 2-dehydrogenase activity
ASR50_RS30880	COG1404	Belongs to the peptidase S8 family
ASR50_RS30900	COG2838	Isocitrate dehydrogenase
ASR50_RS30905	COG0668	transmembrane transport
ASR50_RS30910	COG1024	Enoyl-CoA hydratase
ASR50_RS30920	COG1132	(ABC) transporter
ASR50_RS30925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASR50_RS30935	COG2197	response regulator
ASR50_RS30940	COG3851	Histidine kinase
ASR50_RS30990	COG1653	transport
ASR50_RS30995	COG1175	transmembrane transport
ASR50_RS31005	COG1472	Belongs to the glycosyl hydrolase 3 family
ASR50_RS31015	COG1874	Beta-galactosidase
ASR50_RS31015	COG0366	Alpha amylase catalytic
ASR50_RS31065	COG1309	transcriptional regulator
ASR50_RS31085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS31090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS31095	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS31100	COG0183	Belongs to the thiolase family
ASR50_RS31110	COG1022	Amp-dependent synthetase and ligase
ASR50_RS31135	COG0513	Belongs to the DEAD box helicase family
ASR50_RS31175	COG2319	Wd-40 repeat
ASR50_RS31180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASR50_RS31205	COG1595	DNA-templated transcription, initiation
ASR50_RS31220	COG0765	amino acid transport
ASR50_RS31230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASR50_RS31240	COG1126	abc transporter atp-binding protein
ASR50_RS31245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASR50_RS31250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS31255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS31260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS31275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASR50_RS31285	COG0431	NADPH-dependent FMN reductase
ASR50_RS31290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS31295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASR50_RS31300	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS31305	COG0475	glutathione-regulated potassium exporter activity
ASR50_RS31320	COG0492	ferredoxin-NADP+ reductase activity
ASR50_RS31325	COG2986	histidine ammonia-lyase
ASR50_RS31330	COG5002	protein histidine kinase activity
ASR50_RS31335	COG0745	RESPONSE REGULATOR receiver
ASR50_RS31350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASR50_RS31360	COG0798	PFAM Bile acid sodium symporter
ASR50_RS31365	COG2072	flavoprotein involved in K transport
ASR50_RS31380	COG0640	Transcriptional regulator
ASR50_RS31385	COG2072	flavoprotein involved in K transport
ASR50_RS31405	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS31410	COG1309	transcriptional regulator
ASR50_RS31430	COG3971	2-oxopent-4-enoate hydratase activity
ASR50_RS31450	COG0577	efflux transmembrane transporter activity
ASR50_RS31455	COG1136	(ABC) transporter
ASR50_RS31465	COG3693	PFAM glycoside hydrolase, family 10
ASR50_RS31475	COG2391	methyltransferase activity
ASR50_RS31490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ASR50_RS31500	COG2801	Transposase and inactivated derivatives
ASR50_RS31500	COG3415	Transposase
ASR50_RS31525	COG2801	Transposase and inactivated derivatives
ASR50_RS31525	COG3415	Transposase
ASR50_RS31535	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ASR50_RS31540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASR50_RS31545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASR50_RS31550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASR50_RS31560	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASR50_RS31565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASR50_RS31590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASR50_RS31595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASR50_RS31605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASR50_RS31625	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ASR50_RS31645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASR50_RS31660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ASR50_RS31665	COG1136	(ABC) transporter
ASR50_RS31665	COG0577	efflux transmembrane transporter activity
ASR50_RS31670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASR50_RS31680	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS31685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS31740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ASR50_RS31750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ASR50_RS31770	COG0297	glycogen (starch) synthase activity
ASR50_RS31775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASR50_RS31830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASR50_RS31860	COG3619	membrane
ASR50_RS31870	COG2267	carboxylic ester hydrolase activity
ASR50_RS31880	COG0531	amino acid
ASR50_RS31890	COG0726	polysaccharide deacetylase
ASR50_RS31940	COG0583	DNA-binding transcription factor activity
ASR50_RS31950	COG1053	succinate dehydrogenase
ASR50_RS31955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASR50_RS31960	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ASR50_RS31965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASR50_RS31975	COG3360	Dodecin
ASR50_RS31985	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ASR50_RS31990	COG0121	glutamine amidotransferase
ASR50_RS31995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ASR50_RS32000	COG3572	ergothioneine biosynthetic process
ASR50_RS32020	COG1335	isochorismatase
ASR50_RS32035	COG4221	oxidoreductase activity
ASR50_RS32060	COG0667	Aldo Keto reductase
ASR50_RS32075	COG0517	IMP dehydrogenase activity
ASR50_RS32090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS32100	COG0583	DNA-binding transcription factor activity
ASR50_RS32110	COG2080	2 iron, 2 sulfur cluster binding
ASR50_RS32115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ASR50_RS32120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ASR50_RS32145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASR50_RS32155	COG0242	peptide deformylase activity
ASR50_RS32195	COG0542	response to heat
ASR50_RS32205	COG0577	efflux transmembrane transporter activity
ASR50_RS32205	COG1136	(ABC) transporter
ASR50_RS32210	COG1556	Lactate utilization protein
ASR50_RS32215	COG1139	Iron-sulfur cluster binding protein
ASR50_RS32220	COG0247	lactate metabolic process
ASR50_RS32225	COG1070	Carbohydrate kinase
ASR50_RS32230	COG3347	Dehydrogenase
ASR50_RS32230	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS32240	COG1129	ABC transporter
ASR50_RS32245	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASR50_RS32265	COG1609	Transcriptional regulator
ASR50_RS32280	COG1595	DNA-templated transcription, initiation
ASR50_RS32285	COG1234	tRNA 3'-trailer cleavage
ASR50_RS32295	COG1309	transcriptional regulator
ASR50_RS32305	COG2706	6-phosphogluconolactonase activity
ASR50_RS32345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASR50_RS32350	COG1796	DNA polymerase
ASR50_RS32350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ASR50_RS32355	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS32390	COG0435	Glutathione S-transferase
ASR50_RS32420	COG0667	Aldo Keto reductase
ASR50_RS32465	COG2264	protein methyltransferase activity
ASR50_RS32485	COG0248	Ppx GppA phosphatase
ASR50_RS32525	COG0517	IMP dehydrogenase activity
ASR50_RS32545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ASR50_RS32605	COG0583	DNA-binding transcription factor activity
ASR50_RS32615	COG1132	(ABC) transporter
ASR50_RS32630	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS32635	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS32685	COG0745	RESPONSE REGULATOR receiver
ASR50_RS32690	COG2205	protein histidine kinase activity
ASR50_RS32695	COG1686	Belongs to the peptidase S11 family
ASR50_RS32720	COG2208	phosphoserine phosphatase activity
ASR50_RS32780	COG0673	inositol 2-dehydrogenase activity
ASR50_RS32785	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ASR50_RS32790	COG0667	Aldo Keto reductase
ASR50_RS32795	COG1132	(ABC) transporter
ASR50_RS32880	COG3290	protein histidine kinase activity
ASR50_RS32910	COG0243	molybdopterin cofactor binding
ASR50_RS32935	COG0583	DNA-binding transcription factor activity
ASR50_RS32955	COG2508	Transcriptional regulator
ASR50_RS32960	COG0410	ABC transporter
ASR50_RS32990	COG0667	Aldo Keto reductase
ASR50_RS33030	COG0326	Molecular chaperone. Has ATPase activity
ASR50_RS33045	COG0596	Alpha beta hydrolase
ASR50_RS33050	COG2770	Histidine kinase
ASR50_RS33050	COG2208	phosphoserine phosphatase activity
ASR50_RS33060	COG2308	Evidence 4 Homologs of previously reported genes of
ASR50_RS33060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ASR50_RS33065	COG0367	asparagine synthase
ASR50_RS33085	COG1940	carbohydrate kinase activity
ASR50_RS33085	COG1846	Transcriptional regulator
ASR50_RS33095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASR50_RS33105	COG1940	carbohydrate kinase activity
ASR50_RS33105	COG1846	Transcriptional regulator
ASR50_RS33110	COG0395	ABC-type sugar transport system, permease component
ASR50_RS33115	COG1175	transmembrane transport
ASR50_RS33125	COG1063	alcohol dehydrogenase
ASR50_RS33130	COG1082	Xylose isomerase domain protein TIM barrel
ASR50_RS33135	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ASR50_RS33165	COG1120	ATPase activity
ASR50_RS33175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASR50_RS33190	COG0714	Associated with various cellular activities
ASR50_RS33220	COG1609	Transcriptional regulator
ASR50_RS33240	COG0513	Belongs to the DEAD box helicase family
ASR50_RS33265	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS33270	COG2326	polyphosphate kinase activity
ASR50_RS33275	COG1501	Belongs to the glycosyl hydrolase 31 family
ASR50_RS33280	COG2182	Extracellular solute-binding protein
ASR50_RS33285	COG1175	transmembrane transport
ASR50_RS33290	COG0395	ABC-type sugar transport system, permease component
ASR50_RS33305	COG3537	Alpha-1,2-mannosidase
ASR50_RS33315	COG2188	Transcriptional regulator
ASR50_RS33325	COG0628	permease
ASR50_RS33370	COG1090	epimerase
ASR50_RS33375	COG0346	lactoylglutathione lyase activity
ASR50_RS33380	COG0640	Transcriptional regulator
ASR50_RS33385	COG2259	Doxx family
ASR50_RS33490	COG0395	ABC-type sugar transport system, permease component
ASR50_RS33520	COG1757	Na H antiporter
ASR50_RS33565	COG1733	regulation of RNA biosynthetic process
ASR50_RS33580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASR50_RS33615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ASR50_RS33620	COG1017	nitric oxide dioxygenase activity
ASR50_RS33620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASR50_RS33645	COG0531	amino acid
ASR50_RS33720	COG3537	Alpha-1,2-mannosidase
ASR50_RS33725	COG2045	Belongs to the ComB family
ASR50_RS33765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASR50_RS33770	COG0601	transmembrane transport
ASR50_RS33775	COG4166	transmembrane transport
ASR50_RS33790	COG4948	Mandelate Racemase Muconate Lactonizing
ASR50_RS33795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASR50_RS33810	COG1846	Transcriptional regulator
ASR50_RS33815	COG2409	Drug exporters of the RND superfamily
ASR50_RS33825	COG2814	Major facilitator Superfamily
ASR50_RS33830	COG0191	fructose-bisphosphate aldolase activity
ASR50_RS33840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASR50_RS33845	COG0395	ABC-type sugar transport system, permease component
ASR50_RS33860	COG1349	DNA-binding transcription factor activity
ASR50_RS33870	COG0673	inositol 2-dehydrogenase activity
ASR50_RS33890	COG3708	Transcriptional regulator
ASR50_RS33890	COG2207	Transcriptional regulator
ASR50_RS33915	COG0488	(ABC) transporter
ASR50_RS33920	COG3250	beta-galactosidase activity
ASR50_RS33925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASR50_RS33955	COG0640	Transcriptional regulator
ASR50_RS33965	COG1309	transcriptional regulator
ASR50_RS33970	COG0488	(ABC) transporter
ASR50_RS33975	COG2197	response regulator
ASR50_RS33980	COG4585	Histidine kinase
ASR50_RS34005	COG1349	DNA-binding transcription factor activity
ASR50_RS34010	COG2223	nitrite transmembrane transporter activity
ASR50_RS34030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASR50_RS34055	COG2801	Transposase and inactivated derivatives
ASR50_RS34065	COG3293	Transposase
ASR50_RS34080	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ASR50_RS34095	COG2801	Transposase and inactivated derivatives
ASR50_RS34135	COG2801	Transposase and inactivated derivatives
ASR50_RS34195	COG2130	NADP-dependent
ASR50_RS34200	COG1960	acyl-CoA dehydrogenase activity
ASR50_RS34210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASR50_RS34215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASR50_RS34220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASR50_RS34235	COG0318	PFAM AMP-dependent synthetase and ligase
ASR50_RS34245	COG3321	synthase
ASR50_RS34245	COG0604	alcohol dehydrogenase
ASR50_RS34260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASR50_RS34265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASR50_RS34270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASR50_RS34280	COG3321	synthase
ASR50_RS34280	COG0604	alcohol dehydrogenase
ASR50_RS34300	COG4585	Histidine kinase
ASR50_RS34305	COG2197	response regulator
ASR50_RS34315	COG0596	Alpha beta hydrolase
ASR50_RS34330	COG4106	trans-aconitate 2-methyltransferase activity
ASR50_RS34335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASR50_RS34340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASR50_RS34345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASR50_RS34355	COG0778	Nitroreductase
ASR50_RS34360	COG0477	Major facilitator Superfamily
ASR50_RS34365	COG1028	Short-chain dehydrogenase reductase Sdr
ASR50_RS34370	COG2801	Transposase and inactivated derivatives
ASR50_RS34505	COG0583	DNA-binding transcription factor activity
ASR50_RS34540	COG4221	oxidoreductase activity
ASR50_RS34585	COG4974	Belongs to the 'phage' integrase family
ASR50_RS34605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASR50_RS34610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASR50_RS34615	COG0640	Transcriptional regulator
ASR50_RS34620	COG1316	TRANSCRIPTIONal
ASR50_RS34625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASR50_RS34900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASR50_RS34905	COG3293	Transposase
ASR50_RS35005	COG0791	NLP P60 protein
ASR50_RS35005	COG3883	PFAM NLP P60 protein
ASR50_RS35335	COG3293	Transposase
ASR50_RS35395	COG0420	3'-5' exonuclease activity
ASR50_RS35400	COG0419	ATPase involved in DNA repair
ASR50_RS35410	COG3293	Transposase