locus-tag class description C3K23_RS00115 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS00180 ENOG410836F Transposase C3K23_RS00235 ENOG4108EHY type IV secretion system C3K23_RS00345 ENOG4105CDU Replicative dna helicase C3K23_RS00360 ENOG4105PWE CRISPR-associated protein cas2 C3K23_RS00365 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) C3K23_RS00380 ENOG41060M0 Crispr-associated protein, cse4 family C3K23_RS00445 ENOG4105BZU Histidine kinase C3K23_RS00450 ENOG4105K7N UPF0232 protein C3K23_RS00665 ENOG4105FA0 parb-like partition protein C3K23_RS00670 ENOG4107QJE Chromosome Partitioning Protein C3K23_RS00685 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K23_RS00690 ENOG4108Z40 Transcriptional regulator C3K23_RS00905 ENOG410836F Transposase C3K23_RS00970 ENOG4105CDU Replicative dna helicase C3K23_RS01025 ENOG4107RH8 nuclease SbcCD subunit D C3K23_RS01030 ENOG4105EYH Exonuclease C3K23_RS01045 ENOG4107RBB ABC transporter, permease C3K23_RS01050 ENOG4105C19 ABC transporter C3K23_RS01065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K23_RS01070 ENOG4105BZU Histidine kinase C3K23_RS01085 ENOG4108JQ1 Dehydrogenase C3K23_RS01095 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C3K23_RS01100 ENOG4105CHR reductase C3K23_RS01105 ENOG4106517 Short-chain dehydrogenase reductase Sdr C3K23_RS01145 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C3K23_RS01195 ENOG4105MXW flavin reductase domain protein, FMN-binding C3K23_RS01205 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3K23_RS01250 ENOG4105C8Y Acetylornithine aminotransferase C3K23_RS01270 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3K23_RS01275 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C3K23_RS01280 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C3K23_RS01305 ENOG4108JA1 polyketide synthase C3K23_RS01390 ENOG4107EEY synthase C3K23_RS01420 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K23_RS01430 ENOG41064MX Tetr family transcriptional regulator C3K23_RS01445 ENOG4108IG5 Transcriptional regulator C3K23_RS01455 ENOG41064MX Tetr family transcriptional regulator C3K23_RS01460 ENOG4105F0K SARP family transcriptional regulator C3K23_RS01495 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C3K23_RS01500 ENOG4105W1Y Transcriptional regulator C3K23_RS01515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS01525 ENOG410836F Transposase C3K23_RS01530 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C3K23_RS01550 ENOG4108R86 Transcriptional regulator C3K23_RS01570 ENOG4108IND Tetr family transcriptional regulator C3K23_RS01595 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) C3K23_RS01600 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme C3K23_RS01615 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K23_RS01645 ENOG4105CJA serine threonine protein kinase C3K23_RS01690 ENOG4105EMN RNA polymerase sigma factor C3K23_RS01700 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS01730 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit C3K23_RS01740 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit C3K23_RS01745 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit C3K23_RS01750 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C3K23_RS01755 ENOG4105CHR reductase C3K23_RS01760 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) C3K23_RS01790 ENOG4105C2J ABC transporter C3K23_RS01795 ENOG4108IV0 ABC, transporter C3K23_RS01800 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) C3K23_RS01835 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C3K23_RS01860 ENOG4108JA1 polyketide synthase C3K23_RS01860 ENOG4108JA1 polyketide synthase C3K23_RS01900 ENOG4105C0K Gdp-mannose 4,6-dehydratase C3K23_RS01935 ENOG4108R85 Short chain dehydrogenase C3K23_RS01940 ENOG4105C3F Signal peptidase i C3K23_RS01975 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) C3K23_RS01980 ENOG4105C3U ABC transporter C3K23_RS01985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS02000 ENOG4105D2B acyl-CoA dehydrogenase C3K23_RS02005 ENOG4105D2B acyl-CoA dehydrogenase C3K23_RS02010 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C3K23_RS02030 ENOG4108IJ8 ABC transporter C3K23_RS02040 ENOG4105E90 ABC transporter C3K23_RS02045 ENOG4105E90 ABC transporter C3K23_RS02050 ENOG4106A3M Cytochrome p-450 C3K23_RS02055 ENOG41065KQ synthase C3K23_RS02075 ENOG4105FB2 class II Aldolase C3K23_RS02080 ENOG4105G63 Type III effector Hrp-dependent C3K23_RS02090 ENOG4105C6Z Gluconate C3K23_RS02095 ENOG4105MVE transcriptional regulator C3K23_RS02105 ENOG41066UM arsR family transcriptional regulator C3K23_RS02145 ENOG4108UW5 maltose o-acetyltransferase C3K23_RS02155 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C3K23_RS02160 ENOG4105BZ1 (ABC) transporter C3K23_RS02165 ENOG4105BZ1 (ABC) transporter C3K23_RS02190 ENOG4105E0A ABC, transporter C3K23_RS02195 ENOG4105S6R Iron-hydroxamate transporter permease subunit C3K23_RS02200 ENOG4108U1V ABC transporter, permease C3K23_RS02215 ENOG4107R7A Allophanate hydrolase subunit 2 C3K23_RS02220 ENOG4105P4J Allophanate hydrolase, subunit 1 C3K23_RS02225 ENOG4105E7W lamb ycsf family protein C3K23_RS02235 ENOG4107QND Nitrite extrusion protein C3K23_RS02245 ENOG4107QZF nitrite reductase NADPH large subunit C3K23_RS02250 ENOG4108IFG nitrite reductase, (NAD(P)H) C3K23_RS02255 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C3K23_RS02260 ENOG4107NHD transcriptional regulator C3K23_RS02300 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C3K23_RS02305 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C3K23_RS02310 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C3K23_RS02335 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C3K23_RS02340 ENOG4107Y2X deaminase C3K23_RS02345 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C3K23_RS02350 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) C3K23_RS02355 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) C3K23_RS02360 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C3K23_RS02370 ENOG4105I82 acetyl xylan esterase C3K23_RS02380 ENOG4105DEF Extracellular solute-binding protein, family 5 C3K23_RS02385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K23_RS02395 ENOG4108JQ7 (ABC) transporter C3K23_RS02400 ENOG4105DIK (ABC) transporter C3K23_RS02405 ENOG4105CC5 ABC transporter C3K23_RS02415 ENOG4107XSR periplasmic solute binding protein C3K23_RS02425 ENOG4105VMP Transcriptional regulator C3K23_RS02440 ENOG4106F1P AAA ATPase, central domain protein C3K23_RS02520 ENOG4105CXK mandelate racemase muconate lactonizing C3K23_RS02575 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C3K23_RS02580 ENOG4105KDC 50s ribosomal protein l28 C3K23_RS02585 ENOG4105W0E 50S ribosomal protein L33 C3K23_RS02590 ENOG4105NRA 50s ribosomal protein l31 type b C3K23_RS02600 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C3K23_RS02620 ENOG4105CVN desaturase C3K23_RS02655 ENOG4105DCG PHP domain protein C3K23_RS02680 ENOG4107QN2 dihydrolipoyl dehydrogenase C3K23_RS02685 ENOG41080RH Thioredoxin C3K23_RS02705 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process C3K23_RS02710 ENOG4108V75 Glutamine amidotransferase C3K23_RS02715 ENOG41067HS methyltransferase C3K23_RS02725 ENOG4105WKW Pfam:DUF1458 C3K23_RS02735 ENOG4105DEN Luciferase family C3K23_RS02740 ENOG4105E33 succinate dehydrogenase C3K23_RS02755 ENOG4105C5Q Transcriptional regulator C3K23_RS02760 ENOG4105BZU Histidine kinase C3K23_RS02820 ENOG4108HRK Histidine kinase C3K23_RS02835 ENOG4105DY9 regulatoR C3K23_RS02870 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C3K23_RS02900 ENOG4105BZ1 (ABC) transporter C3K23_RS02905 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C3K23_RS02910 ENOG4108KPJ rna polymerase sigma factor C3K23_RS02920 ENOG4105CV8 reductase C3K23_RS02945 ENOG4105BZU Histidine kinase C3K23_RS02950 ENOG4108ZXC Two component transcriptional regulator, luxr family C3K23_RS02980 ENOG4106T9R serine protease C3K23_RS02985 ENOG4105D0M Protease HtpX homolog C3K23_RS03025 ENOG4105C5X domain protein C3K23_RS03045 ENOG4105C1G acyl-Coa dehydrogenase C3K23_RS03055 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C3K23_RS03065 ENOG4105F1K Glutamine amidotransferase C3K23_RS03070 ENOG4105CTQ phosphohexokinase C3K23_RS03085 ENOG4105SKE transcriptional Regulator LysR family C3K23_RS03105 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C3K23_RS03110 ENOG4105CHF Glutathione S-transferase C3K23_RS03165 ENOG4105F6E Acyl-transferase C3K23_RS03175 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) C3K23_RS03190 ENOG4105KI2 Urea amidohydrolase subunit beta C3K23_RS03195 ENOG4108YZ9 Urea amidohydrolase subunit gamma C3K23_RS03210 ENOG4105K4H Nlp p60 protein C3K23_RS03235 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C3K23_RS03240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3K23_RS03245 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C3K23_RS03265 ENOG4108R6G acetyltransferase C3K23_RS03290 ENOG4108VCA G U mismatch-specific DNA glycosylase C3K23_RS03305 ENOG4105DKQ ROK family C3K23_RS03310 ENOG4105FDP GntR family transcriptional regulator C3K23_RS03315 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 C3K23_RS03355 ENOG410836F Transposase C3K23_RS03375 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS03380 ENOG4105E39 Enoyl-CoA hydratase C3K23_RS03405 ENOG4105CZS beta-ketoacyl synthase C3K23_RS03470 ENOG4105F7P transcriptional regulator AsnC family C3K23_RS03475 ENOG4105EYH Exonuclease C3K23_RS03480 ENOG4107RH8 nuclease SbcCD subunit D C3K23_RS03505 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C3K23_RS03510 ENOG4105K4P CoA-binding domain protein C3K23_RS03530 ENOG4108UW5 maltose o-acetyltransferase C3K23_RS03535 ENOG4108Z0R Transferase C3K23_RS03570 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C3K23_RS03590 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C3K23_RS03610 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C3K23_RS03620 ENOG4105CXN decarboxylase C3K23_RS03640 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C3K23_RS03645 ENOG4105EP9 oxidoreductase C3K23_RS03670 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C3K23_RS03675 ENOG4108J59 Extracellular solute-binding protein, family 5 C3K23_RS03680 ENOG4105CHR reductase C3K23_RS03720 ENOG4105BZU Histidine kinase C3K23_RS03740 ENOG4108Q5Y Membrane C3K23_RS03745 ENOG4105CSW GntR family transcriptional regulator C3K23_RS03755 ENOG4108RNG Permease of the drug metabolite transporter C3K23_RS03775 ENOG4105JAB phenazine biosynthesis protein, phzf family C3K23_RS03805 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C3K23_RS03815 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C3K23_RS03835 ENOG4108UW8 fha domain-containing protein C3K23_RS03885 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C3K23_RS03895 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3K23_RS03915 ENOG4108UQS dipeptidase C3K23_RS03990 ENOG4105JXB ankyrin repeat-containing protein C3K23_RS04005 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3K23_RS04010 ENOG4108VW9 Membrane C3K23_RS04020 ENOG4105DEU major facilitator superfamily C3K23_RS04025 ENOG4105Q70 C3K23_RS04030 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 C3K23_RS04035 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) C3K23_RS04045 ENOG4105EW9 transcriptional regulator AsnC family C3K23_RS04055 ENOG4105C1G acyl-Coa dehydrogenase C3K23_RS04085 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C3K23_RS04090 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase C3K23_RS04095 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C3K23_RS04100 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C3K23_RS04120 ENOG4105ECP epimerase C3K23_RS04125 ENOG4105E2R ROK family C3K23_RS04140 ENOG4105C2W permease C3K23_RS04205 ENOG4105DKT Transcriptional regulator C3K23_RS04210 ENOG4105DJV ribulose-phosphate 3-epimerase C3K23_RS04230 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C3K23_RS04255 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) C3K23_RS04270 ENOG4105SKN orotidine 5''-phosphate decarboxylase C3K23_RS04275 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C3K23_RS04280 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C3K23_RS04285 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C3K23_RS04295 ENOG4105CD3 dihydroorotase C3K23_RS04300 ENOG4105CXT aspartate transcarbamylase C3K23_RS04305 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C3K23_RS04315 ENOG410803B Involved in the transcription termination process (By similarity) C3K23_RS04320 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C3K23_RS04325 ENOG4105DC7 peptidase M24 C3K23_RS04335 ENOG4105D49 3-dehydroquinate synthase C3K23_RS04340 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C3K23_RS04345 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C3K23_RS04350 ENOG4105E2X shikimate dehydrogenase C3K23_RS04355 ENOG4105HHA aminodeoxychorismate lyase C3K23_RS04360 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C3K23_RS04365 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C3K23_RS04380 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C3K23_RS04395 ENOG4105CUT histidyl-tRNA synthetase C3K23_RS04405 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) C3K23_RS04410 ENOG4105C99 atpase involved in dna repair C3K23_RS04420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C3K23_RS04425 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C3K23_RS04430 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C3K23_RS04435 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C3K23_RS04445 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C3K23_RS04450 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C3K23_RS04455 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C3K23_RS04460 ENOG4105CDY transcriptional regulatory protein C3K23_RS04465 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C3K23_RS04470 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C3K23_RS04480 ENOG4105E2K Glycosyl transferase (Group 1 C3K23_RS04485 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase C3K23_RS04505 ENOG4105EYW Ion transport protein C3K23_RS04510 ENOG4105C22 threonyL-tRNA synthetase C3K23_RS04545 ENOG4105KF0 sporulation and cell division protein, SsgA C3K23_RS04575 ENOG4105CRQ synthase (Component I) C3K23_RS04645 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C3K23_RS04650 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) C3K23_RS04665 ENOG4105D01 (LipO)protein C3K23_RS04670 ENOG4105D01 (LipO)protein C3K23_RS04675 ENOG4108UMI ABC transporter, permease C3K23_RS04680 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C3K23_RS04685 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 C3K23_RS04710 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase C3K23_RS04715 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS04720 ENOG4105C57 major facilitator superfamily C3K23_RS04725 ENOG4105RJZ Transcriptional regulator C3K23_RS04740 ENOG4105CH7 arginosuccinase C3K23_RS04750 ENOG4105C09 Bile acid C3K23_RS04755 ENOG4105EYF MMPL domain protein C3K23_RS04765 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS04770 ENOG4105BZU Histidine kinase C3K23_RS04775 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C3K23_RS04780 ENOG4105C8Y Acetylornithine aminotransferase C3K23_RS04785 ENOG4105CAS nag kinase C3K23_RS04790 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C3K23_RS04795 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C3K23_RS04805 ENOG4108Z6Z Transcriptional regulator C3K23_RS04835 ENOG4105E9K Isocitrate dehydrogenase C3K23_RS04870 ENOG4105T38 integral membrane protein C3K23_RS05035 ENOG4105CDU Replicative dna helicase C3K23_RS05195 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C3K23_RS05275 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C3K23_RS05280 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C3K23_RS05285 ENOG4105BZU Histidine kinase C3K23_RS05295 ENOG4108RWN rrna methyltransferase C3K23_RS05300 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C3K23_RS05305 ENOG41084BS 50S ribosomal protein L35 C3K23_RS05310 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C3K23_RS05320 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C3K23_RS05355 ENOG4105C26 Dehydrogenase C3K23_RS05360 ENOG4105C5F glutamine synthetase C3K23_RS05365 ENOG41073TP transcriptional regulator C3K23_RS05370 ENOG4105CUB amino acid C3K23_RS05375 ENOG4108Z86 Glutamine amidotransferase C3K23_RS05400 ENOG4108IJ7 Glycine betaine C3K23_RS05405 ENOG4105HFS 5'-3' exonuclease C3K23_RS05415 ENOG4105K6V RNA polymerase C3K23_RS05420 ENOG4105RNG membrane C3K23_RS05425 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) C3K23_RS05465 ENOG4105JZI cytochrome P450 C3K23_RS05480 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C3K23_RS05485 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C3K23_RS05520 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) C3K23_RS05530 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS05535 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) C3K23_RS05540 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) C3K23_RS05550 ENOG4105E5F proteasome C3K23_RS05555 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) C3K23_RS05585 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS05590 ENOG4105DEF Extracellular solute-binding protein, family 5 C3K23_RS05595 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C3K23_RS05600 ENOG4105C3R Methionine synthase C3K23_RS05610 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C3K23_RS05615 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C3K23_RS05620 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C3K23_RS05635 ENOG4105C8N cysteinyl-tRNA synthetase C3K23_RS05655 ENOG4105D7N magnesium and cobalt transport protein CorA C3K23_RS05665 ENOG4105DYW oxidoreductase C3K23_RS05670 ENOG4105CPC Aldo Keto reductase C3K23_RS05705 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C3K23_RS05715 ENOG4105K78 MarR family Transcriptional regulator C3K23_RS05720 ENOG4105K5B UPF0225 protein C3K23_RS05730 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family C3K23_RS05735 ENOG4105C6Z Gluconate C3K23_RS05755 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein C3K23_RS05770 ENOG4105PTV Nudix Hydrolase C3K23_RS05775 ENOG4105VG5 Membrane C3K23_RS05780 ENOG4105JP4 Inner membrane protein yidG C3K23_RS05785 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C3K23_RS05795 ENOG4105C1G acyl-Coa dehydrogenase C3K23_RS05800 ENOG4108IG5 Transcriptional regulator C3K23_RS05805 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS05830 ENOG4105EHZ conserved protein UCP016719 C3K23_RS05860 ENOG4105CHM Aminotransferase C3K23_RS05905 ENOG4108Z4X TRANSCRIPTIONal C3K23_RS05925 ENOG4108SGK Tetr family transcriptional regulator C3K23_RS05935 ENOG4105F1J Homogentisate 1,2-dioxygenase C3K23_RS05945 ENOG4105EEM helicase C3K23_RS05960 ENOG4107TPY serine threonine protein kinase C3K23_RS05965 ENOG4108TCJ secreted hydrolase C3K23_RS05985 ENOG4105K64 Glycosyl transferase, family 2 C3K23_RS06055 ENOG4107IFA Lipase (EC 3.1.1.3) C3K23_RS06060 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C3K23_RS06065 ENOG4105C0B DNA polymerase III (alpha subunit) C3K23_RS06085 ENOG4106NMR serine protease C3K23_RS06105 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C3K23_RS06110 ENOG4105C57 major facilitator superfamily C3K23_RS06120 ENOG410841Q phosphoesterase PA-phosphatase related protein C3K23_RS06140 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) C3K23_RS06160 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C3K23_RS06170 ENOG4105CAT Cytidine monophosphate kinase C3K23_RS06190 ENOG41065RQ ADP-ribosylation crystallin J1 C3K23_RS06200 ENOG4105FE9 pseudouridine synthase C3K23_RS06205 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C3K23_RS06210 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C3K23_RS06225 ENOG4105DCF alanine dehydrogenase C3K23_RS06235 ENOG4108YZ4 nudix hydrolase C3K23_RS06240 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C3K23_RS06245 ENOG4105BZP glycoside hydrolase 15-related C3K23_RS06280 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C3K23_RS06285 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C3K23_RS06305 ENOG4105DSU hydrolase C3K23_RS06340 ENOG4108VX5 3-methyladenine DNA glycosylase C3K23_RS06350 ENOG4108V1U phospholipid-binding protein C3K23_RS06370 ENOG4105DKW ABC transporter C3K23_RS06385 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS06410 ENOG4105IDI abc transporter atp-binding protein C3K23_RS06415 ENOG4105EAC phosphoserine phosphatase C3K23_RS06430 ENOG4105DJ2 Major Facilitator Superfamily C3K23_RS06435 ENOG4107YCY Transcriptional regulator C3K23_RS06445 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C3K23_RS06455 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C3K23_RS06460 ENOG4105Y3U Transglycosylase-associated protein C3K23_RS06480 ENOG4105CFC Transporter C3K23_RS06490 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3K23_RS06495 ENOG4107QN1 sodium solute C3K23_RS06510 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F C3K23_RS06530 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C3K23_RS06540 ENOG4105CHR reductase C3K23_RS06565 ENOG4105VBF alkaline shock protein C3K23_RS06590 ENOG4105C5H ABC transporter C3K23_RS06610 ENOG4107W7X Aldolase C3K23_RS06630 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C3K23_RS06675 ENOG4105C5R Aminotransferase C3K23_RS06680 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase C3K23_RS06700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C3K23_RS06735 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS06765 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) C3K23_RS06775 ENOG4108UNV SUF system FeS assembly protein, NifU family C3K23_RS06780 ENOG4105C9B Cysteine desulfurase C3K23_RS06785 ENOG4105C3K feS assembly ATPase SufC C3K23_RS06795 ENOG4105JRK feS assembly protein SufD C3K23_RS06810 ENOG4105CJ1 ABC, transporter C3K23_RS06835 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C3K23_RS06840 ENOG4105CV1 Transketolase (EC 2.2.1.1) C3K23_RS06845 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C3K23_RS06860 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) C3K23_RS06865 ENOG4107QP8 phosphohexose isomerase C3K23_RS06880 ENOG4105CP7 Triose-phosphate isomerase C3K23_RS06885 ENOG4105BZA Phosphoglycerate kinase C3K23_RS06890 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C3K23_RS06895 ENOG4105CIE May be required for sporulation (By similarity) C3K23_RS06905 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C3K23_RS06910 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C3K23_RS06925 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C3K23_RS06940 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C3K23_RS06960 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C3K23_RS06965 ENOG4105BZU Histidine kinase C3K23_RS06970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3K23_RS06975 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3K23_RS06980 ENOG4105DXI Major Facilitator superfamily C3K23_RS07030 ENOG4105CSX c4-dicarboxylate anaerobic carrier C3K23_RS07045 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C3K23_RS07065 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C3K23_RS07070 ENOG4105CQ7 ATP-dependent helicase C3K23_RS07090 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) C3K23_RS07105 ENOG4105C32 Amino acid ABC transporter (Permease) C3K23_RS07110 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C3K23_RS07115 ENOG4105C0Z ABC transporter C3K23_RS07120 ENOG4108IV0 ABC, transporter C3K23_RS07145 ENOG4105CGH 5'-nucleotidase C3K23_RS07150 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) C3K23_RS07180 ENOG4105EHE chorismate mutase- prephenate dehydrogenase C3K23_RS07190 ENOG4105C1J atp-dependent rna helicase C3K23_RS07195 ENOG4105VEQ Cold shock protein C3K23_RS07210 ENOG4105CBC glutamate synthase C3K23_RS07245 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C3K23_RS07255 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C3K23_RS07265 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C3K23_RS07270 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C3K23_RS07275 ENOG4105DK0 Indole-3-glycerol phosphate synthase C3K23_RS07295 ENOG4105CRQ synthase (Component I) C3K23_RS07305 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C3K23_RS07315 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C3K23_RS07320 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C3K23_RS07325 ENOG4108176 endoribonuclease L-psp C3K23_RS07330 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C3K23_RS07335 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C3K23_RS07340 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C3K23_RS07345 ENOG4105CIH Imidazole acetol-phosphate transaminase C3K23_RS07350 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C3K23_RS07370 ENOG4108Z66 YbaK ebsC protein C3K23_RS07395 ENOG4105C0B DNA polymerase III (alpha subunit) C3K23_RS07415 ENOG4108UGD Serine Threonine protein kinase C3K23_RS07430 ENOG41082BV acetyltransferase C3K23_RS07440 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C3K23_RS07450 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C3K23_RS07455 ENOG4107VQS DivIVA family C3K23_RS07465 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C3K23_RS07470 ENOG4105DFA alanine racemase domain protein C3K23_RS07475 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C3K23_RS07480 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C3K23_RS07490 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C3K23_RS07500 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C3K23_RS07505 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C3K23_RS07515 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C3K23_RS07520 ENOG4105CJN penicillin-binding protein C3K23_RS07530 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C3K23_RS07540 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3K23_RS07560 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C3K23_RS07565 ENOG4105C2J ABC transporter C3K23_RS07575 ENOG4107Z3H Transcriptional regulator, TetR family C3K23_RS07595 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C3K23_RS07605 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase C3K23_RS07620 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C3K23_RS07630 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C3K23_RS07640 ENOG4108UQY Iron-storage protein C3K23_RS07650 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase C3K23_RS07665 ENOG4105C5I Dehydrogenase C3K23_RS07670 ENOG4108WQH regulatoR C3K23_RS07675 ENOG4105ENE Histidine kinase C3K23_RS07700 ENOG4105DKQ ROK family C3K23_RS07710 ENOG4105D0U Arsenite-activated ATPase (ArsA) C3K23_RS07730 ENOG4105JNK Glycosyl transferase (Group 1 C3K23_RS07765 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) C3K23_RS07780 ENOG4105BZU Histidine kinase C3K23_RS07785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K23_RS07795 ENOG4105BZW Glycerate kinase C3K23_RS07800 ENOG4105C9B Cysteine desulfurase C3K23_RS07805 ENOG4108I0Q anthranilate phosphoribosyltransferase C3K23_RS07810 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C3K23_RS07815 ENOG4107EUI c reductase, iron-sulfur C3K23_RS07820 ENOG4107UDY cytochrome C C3K23_RS07825 ENOG4105CCU oxidase (Subunit III) C3K23_RS07835 ENOG4107UBC ErfK ybiS ycfS ynhG family protein C3K23_RS07840 ENOG4105MCD Part of cytochrome c oxidase, its function is C3K23_RS07845 ENOG4105BZ9 Cytochrome C oxidase, subunit I C3K23_RS07850 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) C3K23_RS07855 ENOG4105C3J Cysteine desulfurase C3K23_RS07860 ENOG4107T4Z adenosine kinase C3K23_RS07885 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C3K23_RS07895 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS07900 ENOG4105BZU Histidine kinase C3K23_RS07930 ENOG4108YZT Adenosylcobinamide kinase C3K23_RS07940 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) C3K23_RS07950 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) C3K23_RS07955 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C3K23_RS07975 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C3K23_RS08025 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) C3K23_RS08030 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C3K23_RS08060 ENOG41064MX Tetr family transcriptional regulator C3K23_RS08065 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 C3K23_RS08075 ENOG4105CMT Dihydroxyacetone kinase C3K23_RS08085 ENOG4105CSR polyphosphate kinase 2 C3K23_RS08090 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3K23_RS08100 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase C3K23_RS08120 ENOG41081F0 Precorrin-8x methylmutase C3K23_RS08130 ENOG4105CTK cobaltochelatase, cobn subunit C3K23_RS08150 ENOG4105C26 Dehydrogenase C3K23_RS08160 ENOG4108222 arsenate reductase C3K23_RS08180 ENOG4107R5B glutamine synthetase C3K23_RS08185 ENOG4107NHD transcriptional regulator C3K23_RS08210 ENOG41060BG Tetr family transcriptional regulator C3K23_RS08230 ENOG4105CG3 alpha amylase, catalytic region C3K23_RS08235 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C3K23_RS08240 ENOG4105D56 permease protein C3K23_RS08245 ENOG4107FKK extracellular solute-binding protein family 1 C3K23_RS08250 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS08280 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) C3K23_RS08300 ENOG4105C5F glutamine synthetase C3K23_RS08320 ENOG4107R16 Multicopper oxidase C3K23_RS08325 ENOG4105C4K Nad synthetase C3K23_RS08335 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C3K23_RS08340 ENOG4107XZ0 Peptidase M50 C3K23_RS08370 ENOG4105JAB phenazine biosynthesis protein, phzf family C3K23_RS08390 ENOG4105EHG Permease protein C3K23_RS08395 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) C3K23_RS08400 ENOG4106A0S C3K23_RS08415 ENOG4105CIK Amidinotransferase C3K23_RS08425 ENOG4105FQP Beta-lactamase C3K23_RS08430 ENOG4105C2C drug resistance transporter, Bcr CflA C3K23_RS08440 ENOG4105CVK Glutamate decarboxylase C3K23_RS08455 ENOG4105JAB phenazine biosynthesis protein, phzf family C3K23_RS08465 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3K23_RS08515 ENOG4107XFJ UPF0246 protein C3K23_RS08520 ENOG4108UHU Aldolase C3K23_RS08535 ENOG4105EGD dinuclear metal center protein, YbgI family C3K23_RS08560 ENOG4105C1G acyl-Coa dehydrogenase C3K23_RS08595 ENOG4107QVI Methyltransferase, type 11 C3K23_RS08600 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C3K23_RS08620 ENOG4105BZ1 (ABC) transporter C3K23_RS08725 ENOG4107T5V SNARE associated Golgi C3K23_RS08740 ENOG4105DAX Pfam:DUF2983 C3K23_RS08790 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C3K23_RS08810 ENOG4108ZGX Histidine kinase C3K23_RS08815 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS08830 ENOG4105CPC Aldo Keto reductase C3K23_RS08835 ENOG4105VUF Transcriptional regulator C3K23_RS08845 ENOG4105C2I pirin domain protein C3K23_RS08865 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C3K23_RS08885 ENOG4107QK4 glycoside hydrolase, family 3 domain protein C3K23_RS08900 ENOG4108ZHJ Organic hydroperoxide resistance protein C3K23_RS08905 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C3K23_RS08925 ENOG4105E8G Major facilitator Superfamily C3K23_RS08930 ENOG4105DFF Rod shape-determining protein mreb C3K23_RS08945 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3K23_RS08960 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K23_RS08965 ENOG4105C1B dTDP-glucose 4-6-dehydratase C3K23_RS08980 ENOG4105CH6 catalase C3K23_RS08990 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone C3K23_RS09005 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein C3K23_RS09015 ENOG4105D4T Citrate transporter C3K23_RS09020 ENOG4108MRH transcriptional regulatory protein C3K23_RS09035 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C3K23_RS09040 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K23_RS09085 ENOG4105DXX methyltransferase C3K23_RS09095 ENOG4105VF7 tolerance protein C3K23_RS09110 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C3K23_RS09115 ENOG4105E2R ROK family C3K23_RS09135 ENOG410905P Pyridoxamine 5-phosphate C3K23_RS09150 ENOG4108XNA Gas vesicle C3K23_RS09210 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) C3K23_RS09220 ENOG4105FDK ABC transporter C3K23_RS09235 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C3K23_RS09240 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) C3K23_RS09250 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C3K23_RS09255 ENOG4105D4Y metalloprotease C3K23_RS09265 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C3K23_RS09275 ENOG4105MSB protein, conserved in bacteria C3K23_RS09285 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C3K23_RS09305 ENOG4107T4Z adenosine kinase C3K23_RS09310 ENOG4105F8D glycoside hydrolase family 4 C3K23_RS09340 ENOG4105K6H D-cysteine desulfhydrase C3K23_RS09360 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C3K23_RS09365 ENOG4107YU2 histidine triad (hIT) protein C3K23_RS09370 ENOG4107RE3 peptidase, S41 C3K23_RS09380 ENOG4107QWG 2-Nitropropane dioxygenase C3K23_RS09385 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C3K23_RS09415 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C3K23_RS09420 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) C3K23_RS09435 ENOG4108YYC ycei family C3K23_RS09450 ENOG4105EPR degv family C3K23_RS09460 ENOG4105C8T Leucyl-tRNA synthetase C3K23_RS09485 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C3K23_RS09500 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C3K23_RS09505 ENOG4105D0M Protease HtpX homolog C3K23_RS09525 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C3K23_RS09535 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C3K23_RS09555 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C3K23_RS09560 ENOG4105K46 50S ribosomal protein l27 C3K23_RS09565 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C3K23_RS09570 ENOG4105C03 ribonuclease C3K23_RS09600 ENOG4105CNI cell division protein FtsW C3K23_RS09620 ENOG4105DFF Rod shape-determining protein mreb C3K23_RS09625 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C3K23_RS09635 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C3K23_RS09640 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C3K23_RS09650 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C3K23_RS09655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C3K23_RS09660 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C3K23_RS09665 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C3K23_RS09685 ENOG4108TGC Acyltransferase C3K23_RS09690 ENOG4107S91 Sodium hydrogen exchanger C3K23_RS09715 ENOG4105C85 amino acid C3K23_RS09725 ENOG4105C85 amino acid C3K23_RS09730 ENOG4105C85 amino acid C3K23_RS09735 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3K23_RS09740 ENOG4105CVK Glutamate decarboxylase C3K23_RS09745 ENOG4105MC2 DSBA oxidoreductase C3K23_RS09775 ENOG4106NZI LysR family Transcriptional regulator C3K23_RS09785 ENOG4105DK7 lysyl-tRNA synthetase C3K23_RS09815 ENOG4105C0W non-ribosomal peptide synthetase C3K23_RS09825 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone C3K23_RS09850 ENOG41087PP glycosyltransferase MGT family C3K23_RS09855 ENOG4105C26 Dehydrogenase C3K23_RS09860 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS09875 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C3K23_RS09885 ENOG4105CIH Imidazole acetol-phosphate transaminase C3K23_RS09910 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C3K23_RS09930 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 C3K23_RS09945 ENOG4105D8X mechanosensitive ion channel C3K23_RS09955 ENOG4105F8D glycoside hydrolase family 4 C3K23_RS09975 ENOG4105CT1 (ABC) transporter C3K23_RS10005 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C3K23_RS10010 ENOG4107SET aldo keto reductase C3K23_RS10030 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C3K23_RS10105 ENOG4108MWI inositol mono-phosphatase C3K23_RS10165 ENOG4105CJ1 ABC, transporter C3K23_RS10180 ENOG4105C26 Dehydrogenase C3K23_RS10185 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) C3K23_RS10190 ENOG4105DH8 myo-inositol catabolism C3K23_RS10200 ENOG4105D7K pfkb domain protein C3K23_RS10230 ENOG4105C7H Helicase, RecD TraA family C3K23_RS10235 ENOG4105D17 glycoside hydrolase, family 3 domain protein C3K23_RS10255 ENOG41060W2 glyoxylate carboligase C3K23_RS10275 ENOG4108XFF C3K23_RS10290 ENOG4105C29 acyl-CoA thioesterase C3K23_RS10305 ENOG4107QX3 carboxylase C3K23_RS10315 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C3K23_RS10320 ENOG4105C1G acyl-Coa dehydrogenase C3K23_RS10355 ENOG4105VMP Transcriptional regulator C3K23_RS10365 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C3K23_RS10390 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) C3K23_RS10400 ENOG4105DUU IucA IucC family protein C3K23_RS10415 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C3K23_RS10430 ENOG4105ECQ AraC Family Transcriptional Regulator C3K23_RS10435 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) C3K23_RS10455 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS10480 ENOG410804D Sensor Signal Transduction Histidine Kinase C3K23_RS10485 ENOG4108RQS Two component transcriptional regulator (Winged helix family C3K23_RS10510 ENOG4108ZM9 phosphoglycerate mutase C3K23_RS10605 ENOG4107ZVI PhiRv2 prophage protein C3K23_RS10625 ENOG4105C3G gtp-binding protein C3K23_RS10640 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C3K23_RS10650 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C3K23_RS10655 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C3K23_RS10660 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) C3K23_RS10675 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) C3K23_RS10685 ENOG4107TPY serine threonine protein kinase C3K23_RS10690 ENOG4107GFK fumarate C3K23_RS10700 ENOG4105C9Q fumarate hydratase class II C3K23_RS10710 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C3K23_RS10720 ENOG4105CH6 catalase C3K23_RS10725 ENOG4105BZ4 penicillin-binding protein C3K23_RS10745 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C3K23_RS10755 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C3K23_RS10760 ENOG4105D3R alkyl hydroperoxide reductase C3K23_RS10780 ENOG4108IAB Phoh family C3K23_RS10785 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C3K23_RS10790 ENOG4105CPC Aldo Keto reductase C3K23_RS10815 ENOG4105CV8 reductase C3K23_RS10820 ENOG4105F27 Major Facilitator C3K23_RS10855 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS10860 ENOG4105BZU Histidine kinase C3K23_RS10935 ENOG4107JEE Short-chain dehydrogenase reductase Sdr C3K23_RS10940 ENOG4105E1F short-chain dehydrogenase reductase C3K23_RS10955 ENOG4105KME endoribonuclease L-psp C3K23_RS10960 ENOG4108FUF Transcriptional regulator, IclR family C3K23_RS10985 ENOG4106T9R serine protease C3K23_RS11005 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) C3K23_RS11025 ENOG4105C7Z Conserved Protein C3K23_RS11080 ENOG4105WMR Protein CrcB homolog C3K23_RS11085 ENOG41083YR Protein CrcB homolog C3K23_RS11120 ENOG4105T1M mycothiol conjugate amidase mca C3K23_RS11130 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C3K23_RS11145 ENOG4105C7B Threonine dehydratase C3K23_RS11150 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C3K23_RS11195 ENOG4105C84 Histidine ammonia-lyase C3K23_RS11200 ENOG4105KDM Diguanylate cyclase with gaf sensor C3K23_RS11205 ENOG4105E39 Enoyl-CoA hydratase C3K23_RS11210 ENOG4108QER Adenylate cyclase C3K23_RS11220 ENOG4105D8K carboxyl transferase C3K23_RS11230 ENOG4107WR6 Maf-like protein C3K23_RS11240 ENOG4108JIK carboxylase C3K23_RS11275 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain C3K23_RS11290 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C3K23_RS11295 ENOG4105C26 Dehydrogenase C3K23_RS11320 ENOG4105NAF rna polymerase sigma factor C3K23_RS11325 ENOG4108KXV response regulator C3K23_RS11330 ENOG41065SU Two-component system sensor kinase C3K23_RS11355 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C3K23_RS11365 ENOG4107RSM transcriptional regulator C3K23_RS11370 ENOG4105D94 Major Facilitator Superfamily C3K23_RS11415 ENOG4105UIB (ABC) transporter C3K23_RS11420 ENOG4108JQ9 ABC transporter C3K23_RS11425 ENOG4105DIH basic membrane C3K23_RS11455 ENOG4105E6M Sulphatase-modifying factor protein C3K23_RS11465 ENOG4107RM1 amidohydrolase C3K23_RS11480 ENOG4105F0R Cytidylyltransferase C3K23_RS11490 ENOG4105K64 Glycosyl transferase, family 2 C3K23_RS11500 ENOG4108NIW Leucine export protein LeuE C3K23_RS11540 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C3K23_RS11565 ENOG4108MMM RNA Polymerase C3K23_RS11600 ENOG4105E2D ec 3.2.1.52 C3K23_RS11620 ENOG4108J01 L-aspartate oxidase C3K23_RS11640 ENOG4105U5Y Transcriptional regulator C3K23_RS11660 ENOG4105VPX protein, conserved in bacteria C3K23_RS11670 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C3K23_RS11675 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C3K23_RS11685 ENOG4108VCT Sulfite exporter TauE/SafE C3K23_RS11710 ENOG4107RN3 metallophosphoesterase C3K23_RS11725 ENOG4107H3J ribonuclease C3K23_RS11770 ENOG4105C31 Tryptophanyl-tRNA synthetase C3K23_RS11800 ENOG4105C8Y Acetylornithine aminotransferase C3K23_RS11810 ENOG4106032 Glutathionylspermidine synthase C3K23_RS11820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3K23_RS11825 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C3K23_RS11850 ENOG4108HQS Glycine betaine C3K23_RS11855 ENOG4108IJ7 Glycine betaine C3K23_RS11885 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3K23_RS11905 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS11915 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C3K23_RS11925 ENOG4105DC1 bifunctional purine biosynthesis protein purh C3K23_RS11955 ENOG4105CMV Succinyl-CoA synthetase subunit beta C3K23_RS11960 ENOG4105DEG Vwa containing coxe family protein C3K23_RS11965 ENOG4105RD5 C3K23_RS11970 ENOG4105KKX ATPase associated with various cellular activities aaa_5 C3K23_RS11990 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C3K23_RS11995 ENOG4105E4C Lytic transglycosylase catalytic C3K23_RS12000 ENOG4105CSV Glutaminase C3K23_RS12025 ENOG4105K4H Nlp p60 protein C3K23_RS12045 ENOG4105CD3 dihydroorotase C3K23_RS12105 ENOG4105C94 Transporter C3K23_RS12110 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS12135 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K23_RS12145 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C3K23_RS12165 ENOG4105C26 Dehydrogenase C3K23_RS12225 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C3K23_RS12230 ENOG4107QQG Dehydrogenase C3K23_RS12235 ENOG4107QVP Dehydrogenase C3K23_RS12245 ENOG4108MMM RNA Polymerase C3K23_RS12250 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS12255 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) C3K23_RS12260 ENOG4105DND Transcriptional regulator C3K23_RS12265 ENOG4105EMU Dehydrogenase C3K23_RS12315 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C3K23_RS12340 ENOG4108097 ATP-binding protein C3K23_RS12345 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 C3K23_RS12350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C3K23_RS12415 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C3K23_RS12425 ENOG4105ECQ AraC Family Transcriptional Regulator C3K23_RS12435 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C3K23_RS12450 ENOG4105CS9 pantothenic acid kinase C3K23_RS12455 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C3K23_RS12460 ENOG4108UJD 30S ribosomal protein S9 C3K23_RS12465 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C3K23_RS12475 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C3K23_RS12480 ENOG4108ZT0 50S ribosomal protein l17 C3K23_RS12490 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C3K23_RS12495 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C3K23_RS12500 ENOG41067V7 50S ribosomal protein L36 C3K23_RS12505 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C3K23_RS12515 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C3K23_RS12520 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C3K23_RS12525 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C3K23_RS12530 ENOG410849U 50S ribosomal protein L30 C3K23_RS12535 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C3K23_RS12540 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C3K23_RS12545 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C3K23_RS12550 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C3K23_RS12560 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C3K23_RS12565 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C3K23_RS12570 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C3K23_RS12575 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C3K23_RS12580 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C3K23_RS12585 ENOG41082SA 50s ribosomal protein l29 C3K23_RS12590 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C3K23_RS12595 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C3K23_RS12600 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C3K23_RS12605 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C3K23_RS12610 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C3K23_RS12615 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C3K23_RS12620 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C3K23_RS12625 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C3K23_RS12630 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C3K23_RS12640 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C3K23_RS12660 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C3K23_RS12665 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C3K23_RS12670 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C3K23_RS12705 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C3K23_RS12710 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C3K23_RS12715 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C3K23_RS12720 ENOG4108VZM 50s ribosomal protein L10 C3K23_RS12725 ENOG4105QCJ Lipoprotein C3K23_RS12740 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C3K23_RS12770 ENOG4107R4N Cell wall formation (By similarity) C3K23_RS12780 ENOG410900P UPF0336 protein C3K23_RS12785 ENOG4105WDJ 50S ribosomal protein L33 C3K23_RS12800 ENOG4105DZC cytosine deaminase C3K23_RS12845 ENOG4107YCY Transcriptional regulator C3K23_RS12920 ENOG4108VPT UPF0234 protein C3K23_RS12925 ENOG4105Y3U Transglycosylase-associated protein C3K23_RS12930 ENOG410901E Membrane C3K23_RS12935 ENOG4105D0M Protease HtpX homolog C3K23_RS12940 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS12945 ENOG4105C8S subunit m C3K23_RS12950 ENOG4105D65 subunit l C3K23_RS12955 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS12960 ENOG4107YX3 NADH dehydrogenase subunit j C3K23_RS12965 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS12970 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) C3K23_RS12975 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3K23_RS12980 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS12985 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3K23_RS13000 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS13005 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein C3K23_RS13010 ENOG4105DQU oxidoreductase, subunit beta C3K23_RS13015 ENOG4105KVH Transcriptional regulator C3K23_RS13020 ENOG4105ECR NmrA family C3K23_RS13055 ENOG4105DUX Transporter C3K23_RS13075 ENOG410667J hydrolase C3K23_RS13085 ENOG4105C9U ATP-dependent DNA helicase RecQ C3K23_RS13090 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS13100 ENOG4105D65 subunit l C3K23_RS13105 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS13110 ENOG41087XN oxidoreductase C3K23_RS13115 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS13120 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) C3K23_RS13125 ENOG4108IEH NADH dehydrogenase subunit g C3K23_RS13130 ENOG4107QIZ NADH dehydrogenase C3K23_RS13140 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS13145 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3K23_RS13150 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS13175 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C3K23_RS13185 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) C3K23_RS13230 ENOG4108EHY type IV secretion system C3K23_RS13340 ENOG4105EC2 ftsk spoIIIe C3K23_RS13345 ENOG4105EV6 Pfam:DUF178 C3K23_RS13350 ENOG4105VEQ Cold shock protein C3K23_RS13360 ENOG4105CHU acetyl-coa acetyltransferase C3K23_RS13365 ENOG4105CHR reductase C3K23_RS13430 ENOG4105CK2 sodium dicarboxylate symporter C3K23_RS13445 ENOG4105DVY radical SAM domain protein C3K23_RS13455 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C3K23_RS13460 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C3K23_RS13465 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C3K23_RS13480 ENOG4105CRE cytochrome C C3K23_RS13490 ENOG4107QIV Cytochrome c biogenesis protein C3K23_RS13495 ENOG4107ZT5 Thiol disulfide interchange protein C3K23_RS13505 ENOG4108RH7 phosphoglycerate mutase C3K23_RS13510 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C3K23_RS13530 ENOG4108UZX fmn reductase C3K23_RS13555 ENOG4105CHH sulfate transporter C3K23_RS13560 ENOG4105E0Y RtcB Protein C3K23_RS13585 ENOG4105DK7 lysyl-tRNA synthetase C3K23_RS13590 ENOG4105C75 arginyL-tRNA synthetase C3K23_RS13595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3K23_RS13615 ENOG4105D52 delta-aminolevulinic acid dehydratase C3K23_RS13620 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C3K23_RS13625 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C3K23_RS13630 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C3K23_RS13635 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C3K23_RS13685 ENOG4105DGU Histone deacetylase C3K23_RS13690 ENOG4106UW1 Major Facilitator superfamily C3K23_RS13715 ENOG4105C31 Tryptophanyl-tRNA synthetase C3K23_RS13720 ENOG4105II7 pyrroline-5-carboxylate reductase C3K23_RS13730 ENOG4105CJ1 ABC, transporter C3K23_RS13760 ENOG4105C01 Dihydroxy-acid dehydratase C3K23_RS13770 ENOG4105EY0 Xylose isomerase domain protein TIM barrel C3K23_RS13780 ENOG4107R33 ppx gppa phosphatase C3K23_RS13785 ENOG4108JWX C3K23_RS13795 ENOG4108KQ5 Integrase catalytic subunit C3K23_RS13820 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C3K23_RS13830 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C3K23_RS13840 ENOG4105NAF rna polymerase sigma factor C3K23_RS13845 ENOG41075QH Lipoprotein CseA C3K23_RS13850 ENOG4108PYU two-component system response regulator C3K23_RS13855 ENOG4108FKE two-component system sensor kinase C3K23_RS13860 ENOG4105DR5 peptidase C3K23_RS13905 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C3K23_RS13915 ENOG4108IYU L-aspartate oxidase C3K23_RS13920 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C3K23_RS13935 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS13950 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS13975 ENOG4105BZU Histidine kinase C3K23_RS13990 ENOG4108EKI Dehydrogenase C3K23_RS14030 ENOG41066YJ Beta-lactamase C3K23_RS14065 ENOG4105C57 major facilitator superfamily C3K23_RS14080 ENOG4105E90 ABC transporter C3K23_RS14085 ENOG4105E90 ABC transporter C3K23_RS14090 ENOG4108IJ8 ABC transporter C3K23_RS14110 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C3K23_RS14120 ENOG4105EUJ GTP cyclohydrolase i C3K23_RS14135 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C3K23_RS14150 ENOG4105F0N pyrophosphate phospho-hydrolase C3K23_RS14160 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN C3K23_RS14165 ENOG4107TXC Transcriptional regulator C3K23_RS14170 ENOG4105CS1 NAD(P)H quinone oxidoreductase C3K23_RS14185 ENOG4105C26 Dehydrogenase C3K23_RS14210 ENOG4105EM2 membrane C3K23_RS14235 ENOG4105C2M dna polymerase I C3K23_RS14255 ENOG4105D0M Protease HtpX homolog C3K23_RS14275 ENOG4105C57 major facilitator superfamily C3K23_RS14295 ENOG4105DR5 peptidase C3K23_RS14300 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C3K23_RS14320 ENOG4108YZJ Pfam:DUF2596 C3K23_RS14325 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C3K23_RS14335 ENOG4105K4H Nlp p60 protein C3K23_RS14360 ENOG4105MKU Transcriptional regulator C3K23_RS14475 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C3K23_RS14480 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C3K23_RS14485 ENOG41090R7 Ferric uptake C3K23_RS14490 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands C3K23_RS14520 ENOG4105PKJ carbohydrate binding C3K23_RS14525 ENOG4105KHC sulfurtransferase C3K23_RS14550 ENOG4107NHD transcriptional regulator C3K23_RS14555 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS14560 ENOG4105CZN Potassium uptake protein C3K23_RS14565 ENOG4107ZYR domain protein C3K23_RS14570 ENOG4105C0H protease C3K23_RS14590 ENOG4108HWW ABC transporter C3K23_RS14595 ENOG4105C2J ABC transporter C3K23_RS14605 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS14615 ENOG4105EF1 ribulokinase C3K23_RS14620 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) C3K23_RS14625 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase C3K23_RS14630 ENOG4105CGH 5'-nucleotidase C3K23_RS14635 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C3K23_RS14685 ENOG4105CHP RNA polymerase C3K23_RS14690 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C3K23_RS14700 ENOG4108M15 ABC transporter C3K23_RS14720 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C3K23_RS14765 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3K23_RS14805 ENOG4105EBM Alpha Beta Hydrolase Fold protein C3K23_RS14875 ENOG4107R37 Glutamate dehydrogenase C3K23_RS14900 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C3K23_RS14905 ENOG4105CJ3 phosphate transporter C3K23_RS14915 ENOG4105VPX protein, conserved in bacteria C3K23_RS14925 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C3K23_RS14935 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C3K23_RS14940 ENOG4105E4C Lytic transglycosylase catalytic C3K23_RS14975 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C3K23_RS15000 ENOG4106JUT Streptomycin 3''-adenylyltransferase C3K23_RS15025 ENOG4106IBS oxygenase C3K23_RS15030 ENOG4105WQT MbtH domain protein C3K23_RS15035 ENOG4105CIH Imidazole acetol-phosphate transaminase C3K23_RS15055 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3K23_RS15110 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C3K23_RS15125 ENOG4105CHJ isochorismatase hydrolase C3K23_RS15130 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS15135 ENOG4105BZU Histidine kinase C3K23_RS15150 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) C3K23_RS15175 ENOG4105C87 Aminotransferase class I and II C3K23_RS15180 ENOG4107RCW fructose-bisphosphate aldolase C3K23_RS15185 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C3K23_RS15200 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C3K23_RS15240 ENOG4105CSH Transporter C3K23_RS15265 ENOG4105KNI merR family transcriptional Regulator C3K23_RS15270 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C3K23_RS15275 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C3K23_RS15280 ENOG4105CFG Acts as a chaperone (By similarity) C3K23_RS15305 ENOG4105K59 histidine triad (HIT) protein C3K23_RS15315 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C3K23_RS15320 ENOG4108M15 ABC transporter C3K23_RS15335 ENOG4108HUF Transporter C3K23_RS15340 ENOG4105E0A ABC, transporter C3K23_RS15345 ENOG4108U1V ABC transporter, permease C3K23_RS15350 ENOG4105DQ5 transport system permease protein C3K23_RS15365 ENOG4105KWG Pfam:DUF1696 C3K23_RS15395 ENOG4105F27 Major Facilitator C3K23_RS15435 ENOG4105DHP deoxycytidine triphosphate deaminase C3K23_RS15465 ENOG4105DF6 Fe-S oxidoreductase C3K23_RS15505 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C3K23_RS15545 ENOG4105XTG Pfam:DUF156 C3K23_RS15550 ENOG4105DZ6 Band 7 protein C3K23_RS15565 ENOG4108KGH TRANSCRIPTIONal C3K23_RS15600 ENOG41068WN C3K23_RS15610 ENOG4105C9M aspartyl-trna synthetase C3K23_RS15625 ENOG4105EUB pirin domain protein C3K23_RS15635 ENOG4105CSU acyl-Coa dehydrogenase C3K23_RS15645 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C3K23_RS15655 ENOG4105DFM M18 family aminopeptidase C3K23_RS15695 ENOG4105DJB Major Facilitator Superfamily C3K23_RS15710 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 C3K23_RS15715 ENOG4105CPP Dehydrogenase, E1 component C3K23_RS15735 ENOG4107QPV Serine Threonine protein kinase C3K23_RS15760 ENOG4107SVH Potassium channel protein C3K23_RS15765 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3K23_RS15775 ENOG4107QSN dihydrolipoamide acetyltransferase C3K23_RS15835 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C3K23_RS15845 ENOG4105TV9 FHA Domain-Containing protein C3K23_RS15850 ENOG4105HZM Fha domain containing protein C3K23_RS15875 ENOG4108RN7 integral membrane protein C3K23_RS15880 ENOG4108U4N (sortase) family C3K23_RS15895 ENOG4105ZJT Cell division protein CrgA C3K23_RS15925 ENOG4105VEQ Cold shock protein C3K23_RS15955 ENOG4108UGD Serine Threonine protein kinase C3K23_RS15995 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3K23_RS16000 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3K23_RS16005 ENOG4105K7N UPF0232 protein C3K23_RS16010 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C3K23_RS16015 ENOG4108J5G 6-phosphogluconate dehydrogenase C3K23_RS16020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C3K23_RS16025 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C3K23_RS16030 ENOG41084CH 50S ribosomal protein l34 C3K23_RS16035 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C3K23_RS16040 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C3K23_RS16045 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C3K23_RS16055 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C3K23_RS16060 ENOG4107QJE Chromosome Partitioning Protein C3K23_RS16075 ENOG4105K63 Thioredoxin C3K23_RS16080 ENOG4105C3M thioredoxin reductase C3K23_RS16095 ENOG4105D9P serine threonine protein kinase C3K23_RS16110 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C3K23_RS16135 ENOG4105BZ4 penicillin-binding protein C3K23_RS16160 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) C3K23_RS16165 ENOG4107YH6 single-stranded DNA-binding protein C3K23_RS16170 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C3K23_RS16175 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C3K23_RS16185 ENOG4105CDU Replicative dna helicase C3K23_RS16240 ENOG4105NAE bifunctional deaminase-reductase domain protein C3K23_RS16245 ENOG4108UW5 maltose o-acetyltransferase C3K23_RS16260 ENOG410849A acetyltransferase, (GNAT) family C3K23_RS16285 ENOG4105C28 cystathionine C3K23_RS16290 ENOG41082T9 Membrane C3K23_RS16295 ENOG4106048 Cupin 2, conserved barrel domain protein C3K23_RS16310 ENOG4105KF0 sporulation and cell division protein, SsgA C3K23_RS16320 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C3K23_RS16335 ENOG4107P2S Transcriptional regulator C3K23_RS16340 ENOG4105CIH Imidazole acetol-phosphate transaminase C3K23_RS16345 ENOG4105C4M (Ubiquinol oxidase) subunit I C3K23_RS16350 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C3K23_RS16355 ENOG4108JJ9 ABC, transporter C3K23_RS16370 ENOG410667J hydrolase C3K23_RS16390 ENOG4105DA5 (ABC) transporter C3K23_RS16410 ENOG410667J hydrolase C3K23_RS16415 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C3K23_RS16420 ENOG4105CQC Prephenate dehydratase C3K23_RS16425 ENOG4105DBE peroxidase C3K23_RS16460 ENOG4107T6F Xaa-Pro aminopeptidase C3K23_RS16475 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C3K23_RS16490 ENOG4105C0H protease C3K23_RS16510 ENOG4105NAF rna polymerase sigma factor C3K23_RS16515 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS16550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K23_RS16560 ENOG4105C57 major facilitator superfamily C3K23_RS16580 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3K23_RS16585 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C3K23_RS16595 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K23_RS16600 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K23_RS16615 ENOG4108Z6B deaminase C3K23_RS16630 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C3K23_RS16655 ENOG4105CHR reductase C3K23_RS16690 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C3K23_RS16715 ENOG4105C12 Phosphoribosylglycinamide synthetase C3K23_RS16730 ENOG4105C8V SAICAR synthetase C3K23_RS16775 ENOG410839H phosphoribosylformylglycinamidine synthase C3K23_RS16780 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C3K23_RS16785 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C3K23_RS16800 ENOG4105CXB phosphoribosylaminoimidazole synthetase C3K23_RS16815 ENOG4108TAC C3K23_RS16835 ENOG4105CQ7 ATP-dependent helicase C3K23_RS16870 ENOG4105C1J atp-dependent rna helicase C3K23_RS16910 ENOG4105Y3U Transglycosylase-associated protein C3K23_RS16930 ENOG4105CPC Aldo Keto reductase C3K23_RS16940 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C3K23_RS16945 ENOG4105D5U fad dependent oxidoreductase C3K23_RS16960 ENOG4105ESP cell wall surface anchor family protein C3K23_RS17035 ENOG41082A2 Alpha beta hydrolase C3K23_RS17045 ENOG4105CVA phosphate C3K23_RS17055 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS17060 ENOG4105ENE Histidine kinase C3K23_RS17070 ENOG4107SNB ankyrin repeat protein YahD C3K23_RS17120 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3K23_RS17140 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C3K23_RS17145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C3K23_RS17155 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C3K23_RS17165 ENOG4105CFH Aspartokinase C3K23_RS17195 ENOG4105D9P serine threonine protein kinase C3K23_RS17240 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3K23_RS17270 ENOG4105BZ4 penicillin-binding protein C3K23_RS17290 ENOG4105KME endoribonuclease L-psp C3K23_RS17300 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C3K23_RS17315 ENOG4105P8F nudix hydrolase C3K23_RS17330 ENOG4105D74 hydrolase C3K23_RS17340 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C3K23_RS17345 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3K23_RS17350 ENOG4105CHH sulfate transporter C3K23_RS17410 ENOG4108I5C dEAD DEAH box helicase C3K23_RS17415 ENOG4105WN5 stage II sporulation protein C3K23_RS17430 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3K23_RS17440 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C3K23_RS17445 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C3K23_RS17520 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C3K23_RS17670 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS17675 ENOG4107FKK extracellular solute-binding protein family 1 C3K23_RS17680 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C3K23_RS17685 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C3K23_RS17690 ENOG4105CHR reductase C3K23_RS17875 ENOG4105H3G oxidoreductase C3K23_RS17880 ENOG41082YX Transcriptional regulator, arsr family C3K23_RS17890 ENOG4105H3G oxidoreductase C3K23_RS17900 ENOG4107YCR Transcriptional regulator, ARSR family C3K23_RS17910 ENOG4105HS2 Arsenate reductase C3K23_RS17915 ENOG4105C3M thioredoxin reductase C3K23_RS17925 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3K23_RS17930 ENOG4107QJZ Glycosyl transferase, family 2 C3K23_RS17955 ENOG4107QN2 dihydrolipoyl dehydrogenase C3K23_RS18100 ENOG4105CHR reductase C3K23_RS18110 ENOG4107TXC Transcriptional regulator C3K23_RS18120 ENOG4106JDR secreted C3K23_RS18135 ENOG4108JQ1 Dehydrogenase C3K23_RS18165 ENOG4108DUX Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C3K23_RS18180 ENOG4105C6F GntR Family Transcriptional Regulator C3K23_RS18230 ENOG4105CEP NADH dehydrogenase C3K23_RS18245 ENOG41082SX arsR family transcriptional regulator C3K23_RS18255 ENOG4107TB5 TRANSCRIPTIONal C3K23_RS18260 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C3K23_RS18285 ENOG4105CGP Urocanate hydratase C3K23_RS18320 ENOG4105EHG Permease protein C3K23_RS18325 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) C3K23_RS18330 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction C3K23_RS18335 ENOG4105KAV tspo and mbr like protein C3K23_RS18350 ENOG4105PTV Nudix Hydrolase C3K23_RS18365 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C3K23_RS18370 ENOG4107UJ9 cyclopropane-fatty-acyl-phospholipid synthase C3K23_RS18390 ENOG4108QER Adenylate cyclase C3K23_RS18420 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) C3K23_RS18490 ENOG410814C multidrug resistance protein C3K23_RS18500 ENOG4105BZU Histidine kinase C3K23_RS18505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K23_RS18520 ENOG4108VJ1 Transcriptional regulator (CarD family C3K23_RS18525 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C3K23_RS18530 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C3K23_RS18550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS18565 ENOG4105C8N cysteinyl-tRNA synthetase C3K23_RS18570 ENOG4105C2N RNA methyltransferase TrmH family group 3 C3K23_RS18580 ENOG4105C37 (CBS) domain C3K23_RS18590 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C3K23_RS18625 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3K23_RS18640 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) C3K23_RS18650 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C3K23_RS18655 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C3K23_RS18660 ENOG4105CIK Amidinotransferase C3K23_RS18680 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C3K23_RS18685 ENOG4105EV4 Multidrug resistance protein mdtH C3K23_RS18705 ENOG4105DVH amino acid C3K23_RS18730 ENOG4107B2H carbonic anhydrase C3K23_RS18745 ENOG4108IG5 Transcriptional regulator C3K23_RS18810 ENOG4105VEQ Cold shock protein C3K23_RS18815 ENOG4105C1J atp-dependent rna helicase C3K23_RS18835 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C3K23_RS18850 ENOG41083YR Protein CrcB homolog C3K23_RS18855 ENOG41083TI Protein CrcB homolog C3K23_RS18860 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS18865 ENOG4105ENE Histidine kinase C3K23_RS18890 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) C3K23_RS18895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3K23_RS18910 ENOG4105BZU Histidine kinase C3K23_RS18920 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C3K23_RS18925 ENOG4105FUA antagonist C3K23_RS18930 ENOG4107MMM Anti-sigma-factor antagonist C3K23_RS19045 ENOG4105CJP fad dependent oxidoreductase C3K23_RS19080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3K23_RS19095 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) C3K23_RS19120 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C3K23_RS19130 ENOG4105BZU Histidine kinase C3K23_RS19145 ENOG4106VEM tagatose-6-phosphate kinase C3K23_RS19150 ENOG4105CE4 GlcNAc 6-P deacetylase C3K23_RS19160 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C3K23_RS19175 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth C3K23_RS19210 ENOG4107ETC gas vesicle protein C3K23_RS19240 ENOG4105C3Q Glycosyl transferase, family 2 C3K23_RS19255 ENOG4105VEQ Cold shock protein C3K23_RS19280 ENOG4105D9U N-acetyltransferase C3K23_RS19290 ENOG4107S5I aldo keto reductase C3K23_RS19295 ENOG4105C5Y PTS System C3K23_RS19300 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C3K23_RS19305 ENOG4105QEK Transcriptional regulator C3K23_RS19310 ENOG4105CVJ phosphoglycerate mutase C3K23_RS19360 ENOG4105EEM helicase C3K23_RS19425 ENOG4105CFI type iii restriction protein res subunit C3K23_RS19470 ENOG4106A3M Cytochrome p-450 C3K23_RS19480 ENOG4107U9T Pfam:Ribonuclease_BN C3K23_RS19495 ENOG4105DQ5 transport system permease protein C3K23_RS19500 ENOG4105TVJ transport system, permease C3K23_RS19505 ENOG4105E0A ABC, transporter C3K23_RS19510 ENOG4108MES Periplasmic binding protein C3K23_RS19515 ENOG4105CJA serine threonine protein kinase C3K23_RS19545 ENOG4105VEQ Cold shock protein C3K23_RS19550 ENOG4105E63 Pfam:DUF178 C3K23_RS19555 ENOG4108UIH futalosine nucleosidase C3K23_RS19565 ENOG4108N0W Major Facilitator superfamily C3K23_RS19590 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C3K23_RS19600 ENOG4105C7N Xanthine uracil vitamin C permease C3K23_RS19625 ENOG4105CPC Aldo Keto reductase C3K23_RS19750 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C3K23_RS19760 ENOG4106A3M Cytochrome p-450 C3K23_RS19780 ENOG4108TQ9 Histidine kinase C3K23_RS19785 ENOG4105CQB FAD linked oxidase domain protein C3K23_RS19795 ENOG4106NZI LysR family Transcriptional regulator C3K23_RS19825 ENOG4107QX3 carboxylase C3K23_RS19840 ENOG4108UKI Enoyl-CoA hydratase C3K23_RS19860 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) C3K23_RS19870 ENOG4108SU4 UPF0309 protein C3K23_RS19950 ENOG4105WN5 stage II sporulation protein C3K23_RS19970 ENOG4105H3G oxidoreductase C3K23_RS19995 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) C3K23_RS20000 ENOG4108762 serine threonine protein kinase C3K23_RS20020 ENOG4105F0K SARP family transcriptional regulator C3K23_RS20050 ENOG4105CSH Transporter C3K23_RS20055 ENOG4105CNV Aldolase C3K23_RS20085 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C3K23_RS20095 ENOG4105CG3 alpha amylase, catalytic region C3K23_RS20115 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS20140 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) C3K23_RS20170 ENOG41065HY 1,4-beta-cellobiosidase C3K23_RS20290 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C3K23_RS20295 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit C3K23_RS20300 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit C3K23_RS20305 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit C3K23_RS20310 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit C3K23_RS20315 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS20320 ENOG4105E39 Enoyl-CoA hydratase C3K23_RS20325 ENOG4105CHU acetyl-coa acetyltransferase C3K23_RS20335 ENOG4108ZJI phenylacetic acid degradation protein C3K23_RS20395 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C3K23_RS20415 ENOG4105KXX peptidase s58 dmpa C3K23_RS20435 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) C3K23_RS20450 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) C3K23_RS20460 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase C3K23_RS20465 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C3K23_RS20475 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3K23_RS20480 ENOG4108RIR Molybdenum cofactor biosynthesis protein C3K23_RS20520 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS20540 ENOG4105F2Z 3-oxoadipate enol-lactonase C3K23_RS20550 ENOG4105CGK Exodeoxyribonuclease III C3K23_RS20560 ENOG4105F95 Monooxygenase C3K23_RS20570 ENOG4105EMU Dehydrogenase C3K23_RS20590 ENOG4105EYF MMPL domain protein C3K23_RS20660 ENOG4105F8V Hydrolase, tatD family C3K23_RS20665 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C3K23_RS20670 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C3K23_RS20675 ENOG4105C5H ABC transporter C3K23_RS20720 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C3K23_RS20725 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS20730 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C3K23_RS20735 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C3K23_RS20755 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) C3K23_RS20765 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C3K23_RS20770 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C3K23_RS20795 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C3K23_RS20800 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C3K23_RS20810 ENOG4105BZU Histidine kinase C3K23_RS20835 ENOG4107TXC Transcriptional regulator C3K23_RS20855 ENOG4108KGH TRANSCRIPTIONal C3K23_RS20890 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3K23_RS20955 ENOG4105CH2 amidohydrolase C3K23_RS20965 ENOG4105W1N transcriptional regulator C3K23_RS20970 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3K23_RS21010 ENOG4105KVH Transcriptional regulator C3K23_RS21050 ENOG4106A3M Cytochrome p-450 C3K23_RS21065 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C3K23_RS21095 ENOG4105CEP NADH dehydrogenase C3K23_RS21100 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C3K23_RS21105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3K23_RS21110 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3K23_RS21135 ENOG4105VZ8 Transcriptional regulator C3K23_RS21160 ENOG4105CHU acetyl-coa acetyltransferase C3K23_RS21210 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS21225 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component C3K23_RS21255 ENOG4105CI2 imidazolone-5-propionate hydrolase C3K23_RS21260 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K23_RS21275 ENOG4105DUX Transporter C3K23_RS21280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K23_RS21285 ENOG41065SU Two-component system sensor kinase C3K23_RS21335 ENOG4105C6Y Udp-glucose 6-dehydrogenase C3K23_RS21345 ENOG4105CH6 catalase C3K23_RS21350 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein C3K23_RS21355 ENOG4108KGH TRANSCRIPTIONal C3K23_RS21375 ENOG4108KGH TRANSCRIPTIONal C3K23_RS21395 ENOG4107V9E glucose-1-phosphate thymidylyltransferase C3K23_RS21405 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) C3K23_RS21420 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) C3K23_RS21425 ENOG4106BQ7 Glycosyl Transferase C3K23_RS21445 ENOG4105DAA L-lactate C3K23_RS21450 ENOG4107QKV phosphomannomutase C3K23_RS21460 ENOG4105W49 UPF0434 protein C3K23_RS21470 ENOG4105EIP mannose-6-phosphate isomerase C3K23_RS21480 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C3K23_RS21535 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C3K23_RS21540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K23_RS21545 ENOG4105BZU Histidine kinase C3K23_RS21550 ENOG4105G3P Lipoprotein lpqB C3K23_RS21560 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea C3K23_RS21565 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS21570 ENOG4105T0Z Conserved Protein C3K23_RS21580 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C3K23_RS21610 ENOG4106NZI LysR family Transcriptional regulator C3K23_RS21630 ENOG4105C7I Dehydrogenase C3K23_RS21655 ENOG4107SJB teichoic acid biosynthesis C3K23_RS21660 ENOG4107SJB teichoic acid biosynthesis C3K23_RS21665 ENOG4108I69 Glycosyl transferases group 1 C3K23_RS21670 ENOG4107SJB teichoic acid biosynthesis C3K23_RS21675 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component C3K23_RS21690 ENOG4105TV9 FHA Domain-Containing protein C3K23_RS21695 ENOG4108UGD Serine Threonine protein kinase C3K23_RS21700 ENOG4108QVN serine threonine protein kinase C3K23_RS21705 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C3K23_RS21720 ENOG4105CAK Cell division ATP-binding protein ftsE C3K23_RS21730 ENOG4105CN1 protease C3K23_RS21735 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C3K23_RS21750 ENOG4106NZI LysR family Transcriptional regulator C3K23_RS21795 ENOG4105EEM helicase C3K23_RS21795 ENOG4105EEM helicase C3K23_RS21805 ENOG4108426 dNA-binding protein C3K23_RS21810 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C3K23_RS21815 ENOG4108UJU UPF0301 protein C3K23_RS21840 ENOG4105E2D ec 3.2.1.52 C3K23_RS21855 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C3K23_RS21875 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C3K23_RS21910 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C3K23_RS21945 ENOG4105E90 ABC transporter C3K23_RS21950 ENOG4108IJ8 ABC transporter C3K23_RS21955 ENOG4105E90 ABC transporter C3K23_RS21965 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase C3K23_RS21975 ENOG4105CQB FAD linked oxidase domain protein C3K23_RS21980 ENOG4105KF0 sporulation and cell division protein, SsgA C3K23_RS22010 ENOG4108RWI nicotinamidase C3K23_RS22020 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) C3K23_RS22035 ENOG4105C85 amino acid C3K23_RS22055 ENOG4108RQ5 Beta-lactamase domain-containing protein C3K23_RS22075 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C3K23_RS22085 ENOG4108M15 ABC transporter C3K23_RS22095 ENOG4105BZU Histidine kinase C3K23_RS22100 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS22105 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C3K23_RS22115 ENOG4105CSH Transporter C3K23_RS22130 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C3K23_RS22140 ENOG4105BZ4 penicillin-binding protein C3K23_RS22170 ENOG4106BRA Membrane C3K23_RS22200 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C3K23_RS22205 ENOG4105ERH Fumarylacetoacetate hydrolase C3K23_RS22210 ENOG4105D9R oxidoreductase C3K23_RS22235 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) C3K23_RS22265 ENOG4108M1A Chitin-binding protein C3K23_RS22310 ENOG4105DV0 amidase (EC 3.5.1.4 C3K23_RS22315 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase C3K23_RS22330 ENOG4105DEN Luciferase family C3K23_RS22345 ENOG4105BZU Histidine kinase C3K23_RS22390 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K23_RS22445 ENOG4105CI3 gtp-binding protein typa C3K23_RS22450 ENOG4107QSI ABC, transporter C3K23_RS22455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K23_RS22460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS22470 ENOG4108JQ7 (ABC) transporter C3K23_RS22480 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K23_RS22485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS22490 ENOG4105C3U ABC transporter C3K23_RS22495 ENOG4108JQ7 (ABC) transporter C3K23_RS22520 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) C3K23_RS22550 ENOG4105CNN ABC, transporter C3K23_RS22555 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS22560 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) C3K23_RS22565 ENOG41063JG Transcriptional regulator C3K23_RS22570 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C3K23_RS22575 ENOG4108Z4U Ferredoxin C3K23_RS22600 ENOG4107R4C succinyl-diaminopimelate desuccinylase C3K23_RS22605 ENOG4108URH decarboxylase C3K23_RS22610 ENOG41075H3 AraC family transcriptional regulator C3K23_RS22635 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C3K23_RS22645 ENOG4105CGU Enoyl-CoA hydratase C3K23_RS22660 ENOG4105DU6 RNA polymerase C3K23_RS22670 ENOG4105C0H protease C3K23_RS22675 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) C3K23_RS22715 ENOG4105D7N magnesium and cobalt transport protein CorA C3K23_RS22730 ENOG4105DXB Major Facilitator superfamily C3K23_RS22735 ENOG4105DB7 PHP domain protein C3K23_RS22740 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C3K23_RS22755 ENOG4105C1J atp-dependent rna helicase C3K23_RS22850 ENOG4105C4R Atp-dependent dna helicase C3K23_RS22880 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) C3K23_RS22945 ENOG41063PX domain protein C3K23_RS22955 ENOG4105DJZ UPF0182 protein C3K23_RS22985 ENOG4107TK4 histidinol-phosphate phosphatase C3K23_RS22995 ENOG4105KPY Small multidrug resistance protein C3K23_RS23005 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C3K23_RS23015 ENOG4108RAV Conserved protein C3K23_RS23025 ENOG4105EMN RNA polymerase sigma factor C3K23_RS23030 ENOG4105WMN AntiSigma factor C3K23_RS23040 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C3K23_RS23050 ENOG41068W2 Cytochrome p-450 C3K23_RS23055 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3K23_RS23060 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3K23_RS23070 ENOG4105D22 carbon starvation protein C3K23_RS23075 ENOG4105FDP GntR family transcriptional regulator C3K23_RS23095 ENOG4105D17 glycoside hydrolase, family 3 domain protein C3K23_RS23100 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C3K23_RS23115 ENOG4105CBD Diacylglycerol kinase C3K23_RS23130 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C3K23_RS23145 ENOG4105K6H D-cysteine desulfhydrase C3K23_RS23165 ENOG41081JD Transcriptional regulator C3K23_RS23170 ENOG4105ESN nucleotide-binding protein C3K23_RS23210 ENOG4108VEQ Superoxide dismutase C3K23_RS23225 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3K23_RS23230 ENOG4105CDA abc transporter atp-binding protein C3K23_RS23240 ENOG4108HW3 (ABC) transporter C3K23_RS23245 ENOG4105C6K Malic enzyme C3K23_RS23250 ENOG4105CB2 alcohol dehydrogenase C3K23_RS23290 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C3K23_RS23320 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C3K23_RS23325 ENOG4105EB3 Histidine kinase C3K23_RS23330 ENOG4108PYU two-component system response regulator C3K23_RS23350 ENOG4105CJ1 ABC, transporter C3K23_RS23375 ENOG4105C57 major facilitator superfamily C3K23_RS23380 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C3K23_RS23385 ENOG4108ZJ4 polysaccharide deacetylase C3K23_RS23455 ENOG4105CJN penicillin-binding protein C3K23_RS23460 ENOG4107QHZ cell cycle protein C3K23_RS23475 ENOG4105FDF Could be involved in DNA repair (By similarity) C3K23_RS23480 ENOG4105E8V Alpha Beta Hydrolase Fold protein C3K23_RS23490 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C3K23_RS23495 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K23_RS23505 ENOG4105C26 Dehydrogenase C3K23_RS23520 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K23_RS23545 ENOG4105C75 arginyL-tRNA synthetase C3K23_RS23550 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C3K23_RS23555 ENOG4105D6E homoserine dehydrogenase C3K23_RS23560 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C3K23_RS23565 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C3K23_RS23575 ENOG4108KGH TRANSCRIPTIONal C3K23_RS23580 ENOG4105VFB Binds the 23S rRNA (By similarity) C3K23_RS23585 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C3K23_RS23590 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3K23_RS23600 ENOG4107ZF2 Phosphatase C3K23_RS23605 ENOG4105ESV Glycosyl transferase, family 4 C3K23_RS23620 ENOG4105ZA1 atp synthase C3K23_RS23625 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) C3K23_RS23630 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C3K23_RS23635 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C3K23_RS23640 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C3K23_RS23645 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C3K23_RS23650 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C3K23_RS23670 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS23675 ENOG4105ENE Histidine kinase C3K23_RS23680 ENOG4105IIP Membrane C3K23_RS23690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS23705 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) C3K23_RS23740 ENOG4105CJ1 ABC, transporter C3K23_RS23760 ENOG4105CHU acetyl-coa acetyltransferase C3K23_RS23785 ENOG41062D9 Histidine kinase C3K23_RS23790 ENOG4105CHJ isochorismatase hydrolase C3K23_RS23830 ENOG4108XEP Alpha Beta Hydrolase Fold protein C3K23_RS23845 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) C3K23_RS23855 ENOG4105WX6 Membrane C3K23_RS23905 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C3K23_RS23910 ENOG4105C6K Malic enzyme C3K23_RS23915 ENOG4105CTQ phosphohexokinase C3K23_RS23920 ENOG4108MRH transcriptional regulatory protein C3K23_RS23925 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C3K23_RS23930 ENOG4107QJT sodium dicarboxylate symporter C3K23_RS23945 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C3K23_RS23965 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C3K23_RS23970 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) C3K23_RS23975 ENOG4105CG3 alpha amylase, catalytic region C3K23_RS23980 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) C3K23_RS23985 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K23_RS24010 ENOG4105BZ1 (ABC) transporter C3K23_RS24015 ENOG4105BZ1 (ABC) transporter C3K23_RS24040 ENOG4107UBC ErfK ybiS ycfS ynhG family protein C3K23_RS24085 ENOG4105VBF alkaline shock protein C3K23_RS24090 ENOG4105ES4 Nitrilase C3K23_RS24105 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) C3K23_RS24110 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C3K23_RS24115 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C3K23_RS24130 ENOG4105EJQ L-serine dehydratase C3K23_RS24135 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C3K23_RS24140 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C3K23_RS24145 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C3K23_RS24165 ENOG4108J59 Extracellular solute-binding protein, family 5 C3K23_RS24170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K23_RS24175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS24180 ENOG4105C3U ABC transporter C3K23_RS24185 ENOG4108JQ7 (ABC) transporter C3K23_RS24190 ENOG4105EN6 Membrane C3K23_RS24215 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C3K23_RS24235 ENOG4105EMU Dehydrogenase C3K23_RS24245 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C3K23_RS24250 ENOG4105BZU Histidine kinase C3K23_RS24255 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C3K23_RS24260 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3K23_RS24270 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C3K23_RS24275 ENOG4105EYF MMPL domain protein C3K23_RS24290 ENOG4107SM8 Adenylate Guanylate cyclase C3K23_RS24300 ENOG4105CPC Aldo Keto reductase C3K23_RS24310 ENOG4105BZU Histidine kinase C3K23_RS24320 ENOG4108ZP8 Acetolactate synthase small subunit C3K23_RS24325 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C3K23_RS24335 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3K23_RS24355 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR C3K23_RS24365 ENOG4105C26 Dehydrogenase C3K23_RS24380 ENOG4105KNE Phosphatidate cytidylyltransferase C3K23_RS24390 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C3K23_RS24395 ENOG4105CM2 brancheD-chain amino acid aminotransferase C3K23_RS24405 ENOG4105CQM Urea amidohydrolase subunit alpha C3K23_RS24410 ENOG4105DWY Agmatine deiminase C3K23_RS24420 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C3K23_RS24430 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein C3K23_RS24460 ENOG4107TXC Transcriptional regulator C3K23_RS24480 ENOG4108YYC ycei family C3K23_RS24490 ENOG4105D8K carboxyl transferase C3K23_RS24510 ENOG4105GWZ Roadblock lc7 family protein C3K23_RS24530 ENOG4105GWZ Roadblock lc7 family protein C3K23_RS24545 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase C3K23_RS24550 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C3K23_RS24595 ENOG41069M3 Transcriptional regulator C3K23_RS24600 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C3K23_RS24605 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C3K23_RS24615 ENOG4105K70 DNA-binding protein C3K23_RS24635 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C3K23_RS24640 ENOG4105CPF Cell wall formation (By similarity) C3K23_RS24660 ENOG4105DWF phosphomethylpyrimidine kinase C3K23_RS24665 ENOG4105VB9 50S ribosomal protein l28 C3K23_RS24670 ENOG4105DP4 dak2 domain fusion protein ylov C3K23_RS24680 ENOG4106H78 methyltransferase C3K23_RS24685 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C3K23_RS24700 ENOG41084BZ 50S ribosomal protein L32 C3K23_RS24705 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C3K23_RS24710 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C3K23_RS24715 ENOG4105K4I Scp-like extracellular C3K23_RS24720 ENOG4108375 Acylphosphatase (EC 3.6.1.7) C3K23_RS24730 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C3K23_RS24765 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) C3K23_RS24775 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C3K23_RS24790 ENOG4105K5M 30s ribosomal protein S16 C3K23_RS24795 ENOG41082KU UPF0109 protein C3K23_RS24800 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C3K23_RS24805 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C3K23_RS24810 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C3K23_RS24815 ENOG4105C3F Signal peptidase i C3K23_RS24825 ENOG4107QYR Signal peptidase i C3K23_RS24830 ENOG4107QYR Signal peptidase i C3K23_RS24845 ENOG41080R2 UPF0102 protein C3K23_RS24860 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K23_RS24870 ENOG4108K5P (LipO)protein C3K23_RS24875 ENOG4105CE9 30S ribosomal protein S2 C3K23_RS24880 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C3K23_RS24885 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C3K23_RS24890 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C3K23_RS24900 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C3K23_RS24910 ENOG4108I5D sulfate abc transporter C3K23_RS24915 ENOG4108UCS ABC, transporter C3K23_RS24940 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3K23_RS24950 ENOG4105C26 Dehydrogenase C3K23_RS24965 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3K23_RS24970 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C3K23_RS24985 ENOG4105C26 Dehydrogenase C3K23_RS24995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C3K23_RS25000 ENOG4105F38 ABC transporter, permease C3K23_RS25005 ENOG4105D38 putrescine abc transporter C3K23_RS25010 ENOG4105CJP fad dependent oxidoreductase C3K23_RS25040 ENOG4105G9B Transcriptional regulator C3K23_RS25050 ENOG4105DKQ ROK family C3K23_RS25055 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C3K23_RS25060 ENOG4105DZP Membrane-associated zinc metalloprotease C3K23_RS25065 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C3K23_RS25080 ENOG4105DEF Extracellular solute-binding protein, family 5 C3K23_RS25085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K23_RS25090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS25110 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C3K23_RS25130 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) C3K23_RS25145 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C3K23_RS25155 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C3K23_RS25160 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C3K23_RS25175 ENOG4105DDN Pentapeptide repeat-containing protein C3K23_RS25180 ENOG4108JQ7 (ABC) transporter C3K23_RS25190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS25195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K23_RS25215 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C3K23_RS25220 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C3K23_RS25225 ENOG4105C1V Peptidase, M16 C3K23_RS25230 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C3K23_RS25255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C3K23_RS25260 ENOG4105CN5 Metallo-Beta-Lactamase C3K23_RS25280 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C3K23_RS25300 ENOG4105BZU Histidine kinase C3K23_RS25305 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C3K23_RS25310 ENOG4107QZI cell division protein FtsK C3K23_RS25320 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) C3K23_RS25330 ENOG4105CEV competence damage-inducible protein C3K23_RS25335 ENOG4105WBV Transcriptional regulator C3K23_RS25340 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction C3K23_RS25350 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) C3K23_RS25370 ENOG4105CIR epoxide hydrolase C3K23_RS25375 ENOG4107QRT dEAD DEAH box helicase C3K23_RS25400 ENOG4105DSF transport protein C3K23_RS25425 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C3K23_RS25430 ENOG4105KC9 Modulates RecA activity (By similarity) C3K23_RS25435 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) C3K23_RS25445 ENOG4107SCK Monooxygenase C3K23_RS25450 ENOG4105DRP amino acid AbC transporter C3K23_RS25455 ENOG4108Q1T ABC transporter C3K23_RS25460 ENOG4107UBR Extracellular solute-binding protein family 3 C3K23_RS25465 ENOG4105CDA abc transporter atp-binding protein C3K23_RS25470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K23_RS25475 ENOG4105EB3 Histidine kinase C3K23_RS25485 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C3K23_RS25505 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C3K23_RS25515 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C3K23_RS25520 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C3K23_RS25530 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C3K23_RS25570 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C3K23_RS25575 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C3K23_RS25580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3K23_RS25605 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C3K23_RS25620 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C3K23_RS25635 ENOG4105C9U ATP-dependent DNA helicase RecQ C3K23_RS25660 ENOG4105DRR Transcriptional regulator, GntR family C3K23_RS25665 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K23_RS25670 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap C3K23_RS25685 ENOG4105YIP Tetr family transcriptional regulator C3K23_RS25700 ENOG4107QN1 sodium solute C3K23_RS25715 ENOG4107QRP cobalamin biosynthesis protein CobW C3K23_RS25720 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3K23_RS25740 ENOG4105DRR Transcriptional regulator, GntR family C3K23_RS25745 ENOG410849S phosphocarrier protein (HPr) C3K23_RS25795 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C3K23_RS25805 ENOG4105F44 Two component transcriptional regulator, winged helix family C3K23_RS25810 ENOG4106F60 Histidine kinase C3K23_RS25835 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C3K23_RS25855 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C3K23_RS25885 ENOG4107VEG TrkA-N domain protein C3K23_RS25890 ENOG4105C0X amino acid C3K23_RS25895 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C3K23_RS25900 ENOG4107QRT dEAD DEAH box helicase C3K23_RS25955 ENOG4105CPQ Dehydrogenase C3K23_RS25960 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component C3K23_RS26055 ENOG4105DHJ ABC, transporter C3K23_RS26125 ENOG4105CV8 reductase C3K23_RS26140 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C3K23_RS26150 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) C3K23_RS26160 ENOG4105E2A Dehydrogenase C3K23_RS26200 ENOG4107RB3 L-asparaginase C3K23_RS26205 ENOG4106UW1 Major Facilitator superfamily C3K23_RS26210 ENOG4108RFG Tetr family transcriptional regulator C3K23_RS26230 ENOG4105EGE secreted protein C3K23_RS26235 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) C3K23_RS26250 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C3K23_RS26270 ENOG4108ZHR arsR family transcriptional regulator C3K23_RS26275 ENOG4108Z6Z Transcriptional regulator C3K23_RS26290 ENOG4105KA0 thioesterase Superfamily protein C3K23_RS26300 ENOG4105DGI Alkaline phosphatase C3K23_RS26345 ENOG4105KVH Transcriptional regulator C3K23_RS26355 ENOG4105DQ5 transport system permease protein C3K23_RS26360 ENOG4105TVJ transport system, permease C3K23_RS26365 ENOG4105E0A ABC, transporter C3K23_RS26380 ENOG4105W0E 50S ribosomal protein L33 C3K23_RS26425 ENOG4105DAA L-lactate C3K23_RS26430 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C3K23_RS26440 ENOG41080R8 Conserved Protein C3K23_RS26455 ENOG4107QRI Phosphoketolase C3K23_RS26500 ENOG4107S1Q Phosphatase C3K23_RS26515 ENOG4105CEU Arginine dihydrolase C3K23_RS26520 ENOG4105DBV ornithine carbamoyltransferase C3K23_RS26525 ENOG4105CUB amino acid C3K23_RS26555 ENOG4106A3M Cytochrome p-450 C3K23_RS26565 ENOG4105D65 subunit l C3K23_RS26570 ENOG4105MKQ Monovalent cation H antiporter subunit C C3K23_RS26575 ENOG4108JPZ Monovalent cation H antiporter subunit D C3K23_RS26590 ENOG4105KJM monovalent cation h antiporter subunit g C3K23_RS26630 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C3K23_RS26660 ENOG4107QM5 aconitate hydratase C3K23_RS26690 ENOG4105C2J ABC transporter C3K23_RS26695 ENOG4108HWW ABC transporter C3K23_RS26700 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C3K23_RS26705 ENOG4105CUB amino acid C3K23_RS26725 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS26730 ENOG4105CHU acetyl-coa acetyltransferase C3K23_RS26750 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C3K23_RS26755 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C3K23_RS26765 ENOG4105C1Q protoporphyrinogen oxidase C3K23_RS26770 ENOG4107JTW chlorite dismutase C3K23_RS26780 ENOG4105E18 UPF0276 protein C3K23_RS26790 ENOG4108ZJ4 polysaccharide deacetylase C3K23_RS26805 ENOG4108KPJ rna polymerase sigma factor C3K23_RS26830 ENOG4105DFU Cell wall formation (By similarity) C3K23_RS26835 ENOG4105E0X reductase C3K23_RS26900 ENOG4108IRC dna polymerase iii C3K23_RS26930 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K23_RS26935 ENOG4108V06 Glutathione peroxidase C3K23_RS26950 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C3K23_RS26955 ENOG4105D7T ABC transporter C3K23_RS26980 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) C3K23_RS26985 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C3K23_RS26995 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C3K23_RS27005 ENOG4107RR1 TRANSCRIPTIONal C3K23_RS27025 ENOG4105CSU acyl-Coa dehydrogenase C3K23_RS27045 ENOG4108J5H Homocysteine s-methyltransferase C3K23_RS27070 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C3K23_RS27080 ENOG4105E0A ABC, transporter C3K23_RS27085 ENOG4105EHG Permease protein C3K23_RS27105 ENOG4105CGD Nad-dependent epimerase dehydratase C3K23_RS27110 ENOG4105CVP deoxyribo-dipyrimidine photolyase C3K23_RS27120 ENOG4105K6V RNA polymerase C3K23_RS27155 ENOG4105M2Z protein tyrosine serine phosphatase C3K23_RS27165 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C3K23_RS27170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3K23_RS27190 ENOG4105C7K acetolactate synthase C3K23_RS27210 ENOG4105DRR Transcriptional regulator, GntR family C3K23_RS27240 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C3K23_RS27245 ENOG4105C7N Xanthine uracil vitamin C permease C3K23_RS27275 ENOG4105ENX hydrolase C3K23_RS27310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3K23_RS27315 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS27325 ENOG41060W2 glyoxylate carboligase C3K23_RS27335 ENOG4105CH6 catalase C3K23_RS27340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C3K23_RS27345 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C3K23_RS27365 ENOG4105VT2 5-hydroxyisourate hydrolase C3K23_RS27375 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C3K23_RS27420 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) C3K23_RS27425 ENOG4108HKT sucrose-6-phosphate hydrolase C3K23_RS27430 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS27450 ENOG4108HKT sucrose-6-phosphate hydrolase C3K23_RS27455 ENOG4105BZ9 Cytochrome C oxidase, subunit I C3K23_RS27460 ENOG4105GRZ Ycii-related protein C3K23_RS27465 ENOG4105CHP RNA polymerase C3K23_RS27480 ENOG4107R9S Malate synthase C3K23_RS27485 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit C3K23_RS27490 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding C3K23_RS27495 ENOG4105C7W Xanthine dehydrogenase C3K23_RS27510 ENOG4107HP6 Transcriptional regulator C3K23_RS27530 ENOG4105BZU Histidine kinase C3K23_RS27535 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS27545 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C3K23_RS27550 ENOG4105FDP GntR family transcriptional regulator C3K23_RS27560 ENOG41062B0 ABC transporter, permease C3K23_RS27565 ENOG4105C2J ABC transporter C3K23_RS27570 ENOG4105DKQ ROK family C3K23_RS27580 ENOG4105C0D helicase C3K23_RS27670 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS27700 ENOG4105BZ1 (ABC) transporter C3K23_RS27715 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C3K23_RS27745 ENOG4105CDA abc transporter atp-binding protein C3K23_RS27750 ENOG4107UBR Extracellular solute-binding protein family 3 C3K23_RS27755 ENOG4105EAD ABC transporter C3K23_RS27760 ENOG4105DRP amino acid AbC transporter C3K23_RS27785 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C3K23_RS27810 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) C3K23_RS27830 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C3K23_RS27835 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C3K23_RS27840 ENOG4105ECY inositol monophosphatase C3K23_RS27865 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C3K23_RS27890 ENOG4107T0D ABC, transporter C3K23_RS27895 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C3K23_RS27905 ENOG4105C5H ABC transporter C3K23_RS27910 ENOG4105BZW Glycerate kinase C3K23_RS27925 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme C3K23_RS27930 ENOG4105C1G acyl-Coa dehydrogenase C3K23_RS27940 ENOG4105CI0 Citrate lyase C3K23_RS27960 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS27965 ENOG4105E0A ABC, transporter C3K23_RS27970 ENOG4105TVJ transport system, permease C3K23_RS27975 ENOG4105DQ5 transport system permease protein C3K23_RS28035 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C3K23_RS28045 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C3K23_RS28060 ENOG4105MKU Transcriptional regulator C3K23_RS28075 ENOG4105D9U N-acetyltransferase C3K23_RS28095 ENOG4105W1N transcriptional regulator C3K23_RS28110 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C3K23_RS28125 ENOG4108Z0Z intracellular protease Pfpi family C3K23_RS28205 ENOG410842T Pterin carbinolamine dehydratase C3K23_RS28220 ENOG4105CV8 reductase C3K23_RS28230 ENOG4105BZG amino acid carrier protein C3K23_RS28235 ENOG4107NQ8 LysR family Transcriptional regulator C3K23_RS28240 ENOG4105DHU Bile acid C3K23_RS28245 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C3K23_RS28255 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3K23_RS28260 ENOG4105DKQ ROK family C3K23_RS28265 ENOG4105C2J ABC transporter C3K23_RS28270 ENOG4105CNN ABC, transporter C3K23_RS28275 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C3K23_RS28345 ENOG4107U9T Pfam:Ribonuclease_BN C3K23_RS28365 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS28370 ENOG4105C2J ABC transporter C3K23_RS28375 ENOG4105CNN ABC, transporter C3K23_RS28380 ENOG4108RVA ribokinase C3K23_RS28385 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C3K23_RS28405 ENOG4108JJA ABC, transporter C3K23_RS28410 ENOG4108JJA ABC, transporter C3K23_RS28425 ENOG4105XYF acetyltransferase C3K23_RS28445 ENOG4108Z6Z Transcriptional regulator C3K23_RS28480 ENOG4105E39 Enoyl-CoA hydratase C3K23_RS28490 ENOG4105DQE DNA ligase C3K23_RS28515 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS28525 ENOG4105JNK Glycosyl transferase (Group 1 C3K23_RS28540 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS28550 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) C3K23_RS28560 ENOG4105C5H ABC transporter C3K23_RS28565 ENOG4105KF0 sporulation and cell division protein, SsgA C3K23_RS28570 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C3K23_RS28580 ENOG4106ETB IIa component C3K23_RS28600 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) C3K23_RS28610 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C3K23_RS28620 ENOG4105CHU acetyl-coa acetyltransferase C3K23_RS28625 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS28630 ENOG4108Z6Z Transcriptional regulator C3K23_RS28635 ENOG4105C94 Transporter C3K23_RS28655 ENOG4105DZC cytosine deaminase C3K23_RS28660 ENOG4105CD3 dihydroorotase C3K23_RS28665 ENOG4108WYP Transcriptional regulator C3K23_RS28680 ENOG4105BZM domain protein C3K23_RS28695 ENOG4105E39 Enoyl-CoA hydratase C3K23_RS28710 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) C3K23_RS28725 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C3K23_RS28750 ENOG4105EY8 ABC transporter C3K23_RS28755 ENOG4105FBD synthase C3K23_RS28765 ENOG4107S11 squalene-associated FAD-dependent desaturase C3K23_RS28775 ENOG4105EWU Squalene--hopene cyclase C3K23_RS28810 ENOG41090WU lipolytic protein G-D-S-L family C3K23_RS28900 ENOG41082YX Transcriptional regulator, arsr family C3K23_RS28905 ENOG4105W1Y Transcriptional regulator C3K23_RS28910 ENOG4105CHH sulfate transporter C3K23_RS28915 ENOG4105H3G oxidoreductase C3K23_RS28930 ENOG4105HS2 Arsenate reductase C3K23_RS28955 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C3K23_RS28960 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C3K23_RS28985 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C3K23_RS29005 ENOG4105CUC YeeE YedE family protein C3K23_RS29010 ENOG4105C1G acyl-Coa dehydrogenase C3K23_RS29015 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS29030 ENOG4107RSM transcriptional regulator C3K23_RS29035 ENOG4105CHU acetyl-coa acetyltransferase C3K23_RS29040 ENOG4105CSH Transporter C3K23_RS29110 ENOG4105EWK phytoene C3K23_RS29115 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C3K23_RS29120 ENOG4106A3M Cytochrome p-450 C3K23_RS29155 ENOG4105C0D helicase C3K23_RS29200 ENOG4105GWZ Roadblock lc7 family protein C3K23_RS29215 ENOG4105C29 acyl-CoA thioesterase C3K23_RS29230 ENOG4105BZ1 (ABC) transporter C3K23_RS29235 ENOG4105BZ1 (ABC) transporter C3K23_RS29260 ENOG4105BZ1 (ABC) transporter C3K23_RS29280 ENOG4107ZED Uncharacterised protein family UPF0047 C3K23_RS29325 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS29335 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C3K23_RS29390 ENOG4107VXZ Hydrolase C3K23_RS29420 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C3K23_RS29435 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C3K23_RS29465 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C3K23_RS29470 ENOG4105YVS arsR family transcriptional regulator C3K23_RS29625 ENOG4105CH7 arginosuccinase C3K23_RS29630 ENOG4105JZC GHMP kinase C3K23_RS29650 ENOG410880H cysteine synthase C3K23_RS29670 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr C3K23_RS29675 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3K23_RS29720 ENOG410841Q phosphoesterase PA-phosphatase related protein C3K23_RS29755 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3K23_RS29770 ENOG4105C5W Aldolase C3K23_RS29800 ENOG4105C10 Electron transfer flavoprotein C3K23_RS29810 ENOG41060NJ transcriptional regulator C3K23_RS29835 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C3K23_RS29845 ENOG4106UW1 Major Facilitator superfamily C3K23_RS29855 ENOG4105E2R ROK family C3K23_RS29875 ENOG4105MVE transcriptional regulator C3K23_RS29910 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C3K23_RS29920 ENOG4105C1J atp-dependent rna helicase C3K23_RS29930 ENOG4108JW7 Maf-like protein C3K23_RS29965 ENOG4105NTW Transcriptional regulator C3K23_RS29975 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C3K23_RS29980 ENOG41068HZ 50S ribosomal protein L32 C3K23_RS29995 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C3K23_RS30020 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C3K23_RS30025 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C3K23_RS30030 ENOG4105DM4 PTS System C3K23_RS30035 ENOG4105DE4 1-phosphofructokinase C3K23_RS30040 ENOG410804X Transcriptional regulator C3K23_RS30060 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS30065 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K23_RS30085 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3K23_RS30090 ENOG4105E0A ABC, transporter C3K23_RS30095 ENOG4105J76 Periplasmic binding protein C3K23_RS30100 ENOG4105S6R Iron-hydroxamate transporter permease subunit C3K23_RS30105 ENOG4105NPE arsR family transcriptional regulator C3K23_RS30110 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase C3K23_RS30155 ENOG4105CJ1 ABC, transporter C3K23_RS30160 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C3K23_RS30165 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C3K23_RS30180 ENOG4105E0T Short-chain dehydrogenase reductase Sdr C3K23_RS30220 ENOG4105NAF rna polymerase sigma factor C3K23_RS30260 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C3K23_RS30275 ENOG4105CSH Transporter C3K23_RS30290 ENOG4108X07 Tetr family transcriptional regulator C3K23_RS30295 ENOG4105CIG ABC transporter C3K23_RS30300 ENOG4105DIM ABC transporter C3K23_RS30315 ENOG4105EUB pirin domain protein C3K23_RS30320 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C3K23_RS30330 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS30350 ENOG4107S91 Sodium hydrogen exchanger C3K23_RS30390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C3K23_RS30400 ENOG4105CYP glycoside hydrolase, family C3K23_RS30410 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3K23_RS30420 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) C3K23_RS30435 ENOG4105D65 subunit l C3K23_RS30440 ENOG4105C8S subunit m C3K23_RS30445 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3K23_RS30480 ENOG4106KE4 Dehydrogenase C3K23_RS30530 ENOG4108K8S endonuclease I C3K23_RS30540 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) C3K23_RS30545 ENOG4107S1E Beta-lactamase C3K23_RS30550 ENOG4108YV4 Universal stress protein C3K23_RS30555 ENOG4105CEY Amp-dependent synthetase and ligase C3K23_RS30600 ENOG4105CQB FAD linked oxidase domain protein C3K23_RS30615 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) C3K23_RS30650 ENOG4107S1E Beta-lactamase C3K23_RS30665 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K23_RS30670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K23_RS30680 ENOG4108JQ7 (ABC) transporter C3K23_RS30695 ENOG4105DTQ mandelate racemase muconate lactonizing C3K23_RS30725 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C3K23_RS30780 ENOG4105CSH Transporter C3K23_RS30790 ENOG4105CHR reductase C3K23_RS30805 ENOG4105BZU Histidine kinase C3K23_RS30810 ENOG4105WH1 Two component transcriptional regulator luxr family C3K23_RS30820 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit C3K23_RS30825 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding C3K23_RS30830 ENOG4105C7W Xanthine dehydrogenase C3K23_RS30855 ENOG4105CSH Transporter C3K23_RS30860 ENOG4108KEZ Dehydrogenase C3K23_RS30880 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C3K23_RS30885 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C3K23_RS30890 ENOG4105ETE Transcriptional regulator (LacI family C3K23_RS30895 ENOG4105C4C beta-galactosidase C3K23_RS30935 ENOG4105F0K SARP family transcriptional regulator C3K23_RS30940 ENOG41064MX Tetr family transcriptional regulator C3K23_RS30950 ENOG4108IG5 Transcriptional regulator