locus-tag	class	description
C3K23_RS00115	COG2197	response regulator
C3K23_RS00180	COG3547	Transposase (IS116 IS110 IS902 family)
C3K23_RS00235	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C3K23_RS00345	COG0305	Participates in initiation and elongation during chromosome replication
C3K23_RS00360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3K23_RS00365	COG1518	maintenance of DNA repeat elements
C3K23_RS00380	COG1857	crispr-associated protein
C3K23_RS00445	COG2205	protein histidine kinase activity
C3K23_RS00450	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C3K23_RS00665	COG1475	DNA binding
C3K23_RS00670	COG1192	Involved in chromosome partitioning
C3K23_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS00690	COG1959	2 iron, 2 sulfur cluster binding
C3K23_RS00825	COG3335	DDE superfamily endonuclease
C3K23_RS00905	COG3547	Transposase (IS116 IS110 IS902 family)
C3K23_RS00970	COG0305	Participates in initiation and elongation during chromosome replication
C3K23_RS01025	COG0420	3'-5' exonuclease activity
C3K23_RS01030	COG0419	ATPase involved in DNA repair
C3K23_RS01045	COG0577	efflux transmembrane transporter activity
C3K23_RS01050	COG1136	(ABC) transporter
C3K23_RS01065	COG0745	RESPONSE REGULATOR receiver
C3K23_RS01070	COG5002	protein histidine kinase activity
C3K23_RS01085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3K23_RS01090	COG0066	3-isopropylmalate dehydratase activity
C3K23_RS01095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3K23_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS01105	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS01145	COG4106	trans-aconitate 2-methyltransferase activity
C3K23_RS01205	COG2814	Major facilitator Superfamily
C3K23_RS01240	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS01250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3K23_RS01270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3K23_RS01275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3K23_RS01280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3K23_RS01285	COG3629	intracellular signal transduction
C3K23_RS01295	COG0477	Major facilitator Superfamily
C3K23_RS01305	COG0604	alcohol dehydrogenase
C3K23_RS01305	COG3321	synthase
C3K23_RS01365	COG3629	intracellular signal transduction
C3K23_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS01495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3K23_RS01500	COG0789	Transcriptional regulator
C3K23_RS01515	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS01525	COG3547	Transposase (IS116 IS110 IS902 family)
C3K23_RS01530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3K23_RS01550	COG1309	transcriptional regulator
C3K23_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS01570	COG1309	transcriptional regulator
C3K23_RS01595	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS01600	COG3246	L-lysine catabolic process to acetate
C3K23_RS01615	COG1404	Belongs to the peptidase S8 family
C3K23_RS01645	COG0515	serine threonine protein kinase
C3K23_RS01700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K23_RS01710	COG0604	alcohol dehydrogenase
C3K23_RS01730	COG3396	Phenylacetate-CoA oxygenase
C3K23_RS01740	COG3396	Phenylacetate-CoA oxygenase
C3K23_RS01745	COG2151	metal-sulfur cluster biosynthetic enzyme
C3K23_RS01750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3K23_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS01760	COG3483	tryptophan 2,3-dioxygenase activity
C3K23_RS01790	COG1129	ABC transporter
C3K23_RS01800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3K23_RS01835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3K23_RS01860	COG0604	alcohol dehydrogenase
C3K23_RS01860	COG3321	synthase
C3K23_RS01860	COG0604	alcohol dehydrogenase
C3K23_RS01860	COG3321	synthase
C3K23_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS01975	COG1124	(ABC) transporter
C3K23_RS01980	COG0444	Belongs to the ABC transporter superfamily
C3K23_RS01985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K23_RS01990	COG0601	transmembrane transport
C3K23_RS02000	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS02005	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS02030	COG1125	glycine betaine transport
C3K23_RS02030	COG0517	IMP dehydrogenase activity
C3K23_RS02040	COG1174	glycine betaine transport
C3K23_RS02045	COG1174	glycine betaine transport
C3K23_RS02050	COG2124	cytochrome p450
C3K23_RS02075	COG0235	Class ii aldolase
C3K23_RS02080	COG3395	kinase activity
C3K23_RS02095	COG1349	DNA-binding transcription factor activity
C3K23_RS02105	COG0640	Transcriptional regulator
C3K23_RS02145	COG0110	maltose O-acetyltransferase activity
C3K23_RS02155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3K23_RS02160	COG1132	(ABC) transporter
C3K23_RS02165	COG1132	(ABC) transporter
C3K23_RS02190	COG1120	ATPase activity
C3K23_RS02200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS02215	COG1984	allophanate hydrolase subunit 2
C3K23_RS02220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C3K23_RS02225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3K23_RS02245	COG2146	nitrite reductase [NAD(P)H] activity
C3K23_RS02245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3K23_RS02250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3K23_RS02255	COG0243	molybdopterin cofactor binding
C3K23_RS02260	COG0745	RESPONSE REGULATOR receiver
C3K23_RS02305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3K23_RS02310	COG2201	protein-glutamate methylesterase activity
C3K23_RS02335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3K23_RS02340	COG0590	tRNA wobble adenosine to inosine editing
C3K23_RS02345	COG0363	glucosamine-6-phosphate deaminase activity
C3K23_RS02350	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C3K23_RS02360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3K23_RS02370	COG3458	cephalosporin-C deacetylase activity
C3K23_RS02380	COG0747	negative chemotaxis
C3K23_RS02385	COG0601	transmembrane transport
C3K23_RS02395	COG4608	Belongs to the ABC transporter superfamily
C3K23_RS02400	COG1121	(ABC) transporter
C3K23_RS02405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3K23_RS02415	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3K23_RS02425	COG3655	Transcriptional regulator
C3K23_RS02440	COG0464	growth
C3K23_RS02520	COG4948	Mandelate Racemase Muconate Lactonizing
C3K23_RS02575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3K23_RS02580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3K23_RS02585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3K23_RS02590	COG0254	rRNA binding
C3K23_RS02600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3K23_RS02620	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C3K23_RS02655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3K23_RS02655	COG1796	DNA polymerase
C3K23_RS02680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3K23_RS02685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K23_RS02705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C3K23_RS02710	COG0121	glutamine amidotransferase
C3K23_RS02715	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C3K23_RS02720	COG2182	Extracellular solute-binding protein
C3K23_RS02725	COG3360	Dodecin
C3K23_RS02735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K23_RS02740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3K23_RS02745	COG1053	succinate dehydrogenase
C3K23_RS02755	COG0583	DNA-binding transcription factor activity
C3K23_RS02820	COG3275	phosphorelay sensor kinase activity
C3K23_RS02825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K23_RS02835	COG3279	Response regulator of the LytR AlgR family
C3K23_RS02840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3K23_RS02870	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3K23_RS02875	COG3693	PFAM glycoside hydrolase, family 10
C3K23_RS02900	COG1132	(ABC) transporter
C3K23_RS02905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3K23_RS02910	COG1595	DNA-templated transcription, initiation
C3K23_RS02920	COG0656	L-ascorbic acid biosynthetic process
C3K23_RS02940	COG0784	Response regulator, receiver
C3K23_RS02945	COG4251	negative regulation of phosphorylation
C3K23_RS02950	COG4566	intracellular signal transduction
C3K23_RS02985	COG0501	Belongs to the peptidase M48B family
C3K23_RS02990	COG2723	6-phospho-beta-galactosidase activity
C3K23_RS02995	COG0395	ABC-type sugar transport system, permease component
C3K23_RS03000	COG1175	transmembrane transport
C3K23_RS03025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K23_RS03045	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS03055	COG0242	peptide deformylase activity
C3K23_RS03065	COG3442	glutamine amidotransferase
C3K23_RS03070	COG0205	6-phosphofructokinase activity
C3K23_RS03080	COG2208	phosphoserine phosphatase activity
C3K23_RS03080	COG2770	Histidine kinase
C3K23_RS03085	COG0583	DNA-binding transcription factor activity
C3K23_RS03090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3K23_RS03110	COG0435	Glutathione S-transferase
C3K23_RS03120	COG2175	clavaminate synthase activity
C3K23_RS03135	COG1132	(ABC) transporter
C3K23_RS03165	COG0204	Acyl-transferase
C3K23_RS03170	COG0829	nickel cation binding
C3K23_RS03175	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C3K23_RS03185	COG0804	urea catabolic process
C3K23_RS03190	COG0832	Belongs to the urease beta subunit family
C3K23_RS03195	COG0831	urea catabolic process
C3K23_RS03205	COG0740	serine-type endopeptidase activity
C3K23_RS03210	COG1388	LysM domain
C3K23_RS03210	COG3103	Sh3 type 3 domain protein
C3K23_RS03210	COG0791	NLP P60 protein
C3K23_RS03235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3K23_RS03240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3K23_RS03245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C3K23_RS03255	COG0488	(ABC) transporter
C3K23_RS03305	COG1940	carbohydrate kinase activity
C3K23_RS03310	COG2188	Transcriptional regulator
C3K23_RS03335	COG0626	cystathionine gamma-synthase activity
C3K23_RS03355	COG3547	Transposase (IS116 IS110 IS902 family)
C3K23_RS03375	COG0318	PFAM AMP-dependent synthetase and ligase
C3K23_RS03380	COG1024	Enoyl-CoA hydratase
C3K23_RS03405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3K23_RS03470	COG1522	sequence-specific DNA binding
C3K23_RS03475	COG0419	ATPase involved in DNA repair
C3K23_RS03480	COG0420	3'-5' exonuclease activity
C3K23_RS03505	COG1739	Uncharacterized protein family UPF0029
C3K23_RS03510	COG1832	CoA-binding protein
C3K23_RS03530	COG0110	maltose O-acetyltransferase activity
C3K23_RS03570	COG0583	DNA-binding transcription factor activity
C3K23_RS03590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3K23_RS03610	COG1968	undecaprenyl-diphosphatase activity
C3K23_RS03620	COG1982	Orn Lys Arg decarboxylase major
C3K23_RS03640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3K23_RS03670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3K23_RS03720	COG4251	negative regulation of phosphorylation
C3K23_RS03740	COG0697	spore germination
C3K23_RS03755	COG0697	spore germination
C3K23_RS03805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3K23_RS03805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3K23_RS03815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3K23_RS03835	COG1716	ATPase activity
C3K23_RS03855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3K23_RS03885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3K23_RS03895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3K23_RS03915	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C3K23_RS04005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K23_RS04010	COG2364	Membrane
C3K23_RS04020	COG2270	Major facilitator Superfamily
C3K23_RS04030	COG3030	protein affecting phage T7 exclusion by the F plasmid
C3K23_RS04035	COG0463	Glycosyl transferase, family 2
C3K23_RS04055	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS04085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3K23_RS04090	COG0140	phosphoribosyl-ATP diphosphatase activity
C3K23_RS04095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3K23_RS04100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3K23_RS04100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3K23_RS04105	COG3201	nicotinamide mononucleotide transporter
C3K23_RS04120	COG1090	epimerase
C3K23_RS04125	COG1846	Transcriptional regulator
C3K23_RS04125	COG1940	carbohydrate kinase activity
C3K23_RS04130	COG0738	Major facilitator superfamily
C3K23_RS04140	COG2233	PERMEase
C3K23_RS04165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3K23_RS04205	COG2390	Transcriptional regulator
C3K23_RS04210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3K23_RS04215	COG2318	DinB family
C3K23_RS04230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3K23_RS04255	COG1758	RNA polymerase activity
C3K23_RS04270	COG0284	orotidine-5'-phosphate decarboxylase activity
C3K23_RS04275	COG0167	dihydroorotate dehydrogenase activity
C3K23_RS04280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3K23_RS04285	COG0505	Belongs to the CarA family
C3K23_RS04295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3K23_RS04300	COG0540	Belongs to the ATCase OTCase family
C3K23_RS04305	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3K23_RS04315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3K23_RS04320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3K23_RS04325	COG0006	proline dipeptidase activity
C3K23_RS04335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3K23_RS04340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3K23_RS04345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3K23_RS04350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3K23_RS04355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3K23_RS04360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3K23_RS04365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3K23_RS04380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3K23_RS04395	COG0124	histidyl-tRNA synthetase
C3K23_RS04405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3K23_RS04410	COG1196	nuclear chromosome segregation
C3K23_RS04420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3K23_RS04425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3K23_RS04430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3K23_RS04435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3K23_RS04445	COG2255	four-way junction helicase activity
C3K23_RS04450	COG0632	four-way junction helicase activity
C3K23_RS04455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3K23_RS04460	COG0217	transcriptional regulatory protein
C3K23_RS04465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3K23_RS04470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C3K23_RS04480	COG0438	transferase activity, transferring glycosyl groups
C3K23_RS04485	COG1560	Kdo2-lipid A biosynthetic process
C3K23_RS04490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3K23_RS04505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3K23_RS04510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3K23_RS04645	COG1648	precorrin-2 dehydrogenase activity
C3K23_RS04645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3K23_RS04650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3K23_RS04665	COG1464	Belongs to the NlpA lipoprotein family
C3K23_RS04670	COG1464	Belongs to the NlpA lipoprotein family
C3K23_RS04675	COG2011	ABC-type metal ion transport system permease component
C3K23_RS04680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3K23_RS04685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3K23_RS04710	COG0584	glycerophosphoryl diester phosphodiesterase
C3K23_RS04715	COG0204	Acyl-transferase
C3K23_RS04715	COG0318	PFAM AMP-dependent synthetase and ligase
C3K23_RS04720	COG0477	Major facilitator Superfamily
C3K23_RS04740	COG0165	Argininosuccinate lyase
C3K23_RS04750	COG0385	Bile acid
C3K23_RS04755	COG2409	Drug exporters of the RND superfamily
C3K23_RS04765	COG2197	response regulator
C3K23_RS04770	COG4585	Histidine kinase
C3K23_RS04775	COG1438	arginine binding
C3K23_RS04780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3K23_RS04785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3K23_RS04790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3K23_RS04795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3K23_RS04835	COG2838	Isocitrate dehydrogenase
C3K23_RS04865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K23_RS04870	COG0697	spore germination
C3K23_RS05035	COG0305	Participates in initiation and elongation during chromosome replication
C3K23_RS05195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3K23_RS05275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K23_RS05275	COG0072	phenylalanine-tRNA ligase activity
C3K23_RS05280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3K23_RS05285	COG5002	protein histidine kinase activity
C3K23_RS05295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3K23_RS05300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3K23_RS05305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3K23_RS05310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3K23_RS05320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3K23_RS05355	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS05360	COG0174	glutamine synthetase
C3K23_RS05365	COG2186	Transcriptional regulator
C3K23_RS05370	COG0531	amino acid
C3K23_RS05375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3K23_RS05400	COG0517	IMP dehydrogenase activity
C3K23_RS05400	COG4175	Glycine betaine
C3K23_RS05405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3K23_RS05415	COG1595	DNA-templated transcription, initiation
C3K23_RS05425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3K23_RS05435	COG0564	pseudouridine synthase activity
C3K23_RS05465	COG2124	cytochrome p450
C3K23_RS05480	COG0805	protein transport
C3K23_RS05485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3K23_RS05520	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3K23_RS05530	COG1609	Transcriptional regulator
C3K23_RS05535	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3K23_RS05540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3K23_RS05550	COG4122	O-methyltransferase activity
C3K23_RS05555	COG1222	aaa ATPase
C3K23_RS05575	COG0517	IMP dehydrogenase activity
C3K23_RS05575	COG1994	Peptidase M50
C3K23_RS05585	COG2197	response regulator
C3K23_RS05590	COG0747	negative chemotaxis
C3K23_RS05600	COG1410	methionine synthase
C3K23_RS05600	COG0646	methionine synthase
C3K23_RS05610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3K23_RS05615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3K23_RS05620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3K23_RS05635	COG0215	cysteine-tRNA ligase activity
C3K23_RS05655	COG0598	Magnesium transport protein CorA
C3K23_RS05665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K23_RS05670	COG0667	Aldo Keto reductase
C3K23_RS05705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K23_RS05715	COG3189	MarR family transcriptional regulator
C3K23_RS05720	COG3012	SEC-C Motif Domain Protein
C3K23_RS05730	COG3265	gluconokinase activity
C3K23_RS05755	COG3573	Dehydrogenase
C3K23_RS05770	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C3K23_RS05775	COG2149	membrane
C3K23_RS05795	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS05805	COG0318	PFAM AMP-dependent synthetase and ligase
C3K23_RS05820	COG0488	(ABC) transporter
C3K23_RS05830	COG3876	Protein conserved in bacteria
C3K23_RS05860	COG0436	Aminotransferase
C3K23_RS05895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3K23_RS05925	COG1309	transcriptional regulator
C3K23_RS05935	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C3K23_RS05940	COG2188	Transcriptional regulator
C3K23_RS05945	COG3973	AAA domain
C3K23_RS05960	COG0515	serine threonine protein kinase
C3K23_RS05965	COG2755	lipolytic protein G-D-S-L family
C3K23_RS05985	COG1216	Glycosyl transferase, family 2
C3K23_RS06060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3K23_RS06065	COG0587	DNA-directed DNA polymerase activity
C3K23_RS06080	COG0330	HflC and HflK could
C3K23_RS06105	COG1799	cell septum assembly
C3K23_RS06110	COG0477	Major facilitator Superfamily
C3K23_RS06120	COG0671	phosphoesterase, PA-phosphatase related
C3K23_RS06140	COG0438	transferase activity, transferring glycosyl groups
C3K23_RS06160	COG1160	GTP binding
C3K23_RS06170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3K23_RS06190	COG1397	ADP-ribosylglycohydrolase
C3K23_RS06200	COG1187	pseudouridine synthase activity
C3K23_RS06205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3K23_RS06210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C3K23_RS06225	COG0686	Belongs to the AlaDH PNT family
C3K23_RS06235	COG0494	nUDIX hydrolase
C3K23_RS06240	COG0504	CTP synthase activity
C3K23_RS06245	COG3387	PFAM Glycoside hydrolase 15-related
C3K23_RS06280	COG0497	DNA recombination
C3K23_RS06285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3K23_RS06305	COG0647	UMP catabolic process
C3K23_RS06340	COG2094	Belongs to the DNA glycosylase MPG family
C3K23_RS06350	COG1881	PFAM PEBP family protein
C3K23_RS06370	COG1119	ATPase activity
C3K23_RS06385	COG2197	response regulator
C3K23_RS06410	COG1716	ATPase activity
C3K23_RS06410	COG0842	Transport permease protein
C3K23_RS06410	COG1131	(ABC) transporter
C3K23_RS06415	COG0560	Phosphoserine phosphatase
C3K23_RS06415	COG3830	Belongs to the UPF0237 family
C3K23_RS06430	COG2807	transmembrane transport
C3K23_RS06435	COG2186	Transcriptional regulator
C3K23_RS06445	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3K23_RS06455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3K23_RS06460	COG2261	transglycosylase associated protein
C3K23_RS06480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C3K23_RS06490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3K23_RS06495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K23_RS06510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3K23_RS06530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3K23_RS06590	COG0488	(ABC) transporter
C3K23_RS06610	COG0235	Class ii aldolase
C3K23_RS06630	COG1492	cobalamin metabolic process
C3K23_RS06675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3K23_RS06680	COG0456	acetyltransferase
C3K23_RS06690	COG1917	Cupin 2, conserved barrel domain protein
C3K23_RS06700	COG1902	pentaerythritol trinitrate reductase activity
C3K23_RS06735	COG2197	response regulator
C3K23_RS06765	COG2171	N-acyltransferase activity
C3K23_RS06775	COG0822	iron-sulfur transferase activity
C3K23_RS06780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3K23_RS06785	COG0396	ATPase activity
C3K23_RS06795	COG0719	Fe-S assembly protein
C3K23_RS06810	COG1131	(ABC) transporter
C3K23_RS06835	COG0109	protoheme IX farnesyltransferase activity
C3K23_RS06840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3K23_RS06845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3K23_RS06860	COG0363	glucosamine-6-phosphate deaminase activity
C3K23_RS06865	COG0166	Belongs to the GPI family
C3K23_RS06875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3K23_RS06880	COG0149	triose-phosphate isomerase activity
C3K23_RS06885	COG0126	phosphoglycerate kinase activity
C3K23_RS06890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3K23_RS06895	COG1481	regulation of sporulation
C3K23_RS06905	COG1660	Displays ATPase and GTPase activities
C3K23_RS06910	COG0322	excinuclease ABC activity
C3K23_RS06925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3K23_RS06940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3K23_RS06960	COG0556	nucleotide-excision repair
C3K23_RS06970	COG0584	glycerophosphoryl diester phosphodiesterase
C3K23_RS06980	COG0477	Major facilitator Superfamily
C3K23_RS07030	COG1288	antiporter activity
C3K23_RS07045	COG0237	dephospho-CoA kinase activity
C3K23_RS07065	COG2226	methyltransferase
C3K23_RS07070	COG1643	Atp-dependent helicase
C3K23_RS07090	COG2050	protein possibly involved in aromatic compounds catabolism
C3K23_RS07105	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3K23_RS07145	COG0737	Belongs to the 5'-nucleotidase family
C3K23_RS07150	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C3K23_RS07180	COG0287	Prephenate dehydrogenase
C3K23_RS07180	COG1605	Chorismate mutase
C3K23_RS07190	COG0513	Belongs to the DEAD box helicase family
C3K23_RS07195	COG1278	Cold shock
C3K23_RS07210	COG0067	glutamate synthase
C3K23_RS07210	COG0069	glutamate synthase activity
C3K23_RS07210	COG0070	glutamate synthase
C3K23_RS07245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3K23_RS07255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3K23_RS07265	COG0159	tryptophan synthase activity
C3K23_RS07270	COG0133	tryptophan synthase activity
C3K23_RS07275	COG0134	indole-3-glycerol-phosphate synthase activity
C3K23_RS07295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3K23_RS07305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3K23_RS07315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C3K23_RS07320	COG0107	imidazoleglycerol-phosphate synthase activity
C3K23_RS07325	COG0251	oxidation-reduction process
C3K23_RS07330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3K23_RS07335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3K23_RS07340	COG0131	Imidazoleglycerol-phosphate dehydratase
C3K23_RS07345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3K23_RS07350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3K23_RS07370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3K23_RS07390	COG1432	Conserved Protein
C3K23_RS07395	COG0587	DNA-directed DNA polymerase activity
C3K23_RS07415	COG0515	serine threonine protein kinase
C3K23_RS07430	COG2153	protein acetylation
C3K23_RS07440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3K23_RS07450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3K23_RS07455	COG3599	regulation of cell shape
C3K23_RS07465	COG1799	cell septum assembly
C3K23_RS07470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3K23_RS07480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3K23_RS07485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3K23_RS07490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3K23_RS07500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3K23_RS07505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3K23_RS07515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3K23_RS07520	COG0768	penicillin binding
C3K23_RS07530	COG0275	rRNA processing
C3K23_RS07540	COG0714	Associated with various cellular activities
C3K23_RS07560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3K23_RS07565	COG1129	ABC transporter
C3K23_RS07575	COG1309	transcriptional regulator
C3K23_RS07595	COG0352	thiamine-phosphate diphosphorylase activity
C3K23_RS07605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3K23_RS07610	COG2022	thiamine diphosphate biosynthetic process
C3K23_RS07610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3K23_RS07620	COG2022	thiamine diphosphate biosynthetic process
C3K23_RS07625	COG0515	serine threonine protein kinase
C3K23_RS07625	COG2815	serine threonine protein kinase
C3K23_RS07630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C3K23_RS07635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3K23_RS07640	COG2193	ferroxidase activity
C3K23_RS07645	COG0243	molybdopterin cofactor binding
C3K23_RS07650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C3K23_RS07665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3K23_RS07670	COG2197	response regulator
C3K23_RS07675	COG4585	Histidine kinase
C3K23_RS07700	COG1940	carbohydrate kinase activity
C3K23_RS07710	COG0003	Pfam Anion-transporting ATPase
C3K23_RS07730	COG0438	transferase activity, transferring glycosyl groups
C3K23_RS07765	COG0705	Rhomboid family
C3K23_RS07780	COG5002	protein histidine kinase activity
C3K23_RS07785	COG0745	RESPONSE REGULATOR receiver
C3K23_RS07795	COG1929	Belongs to the glycerate kinase type-1 family
C3K23_RS07800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3K23_RS07805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3K23_RS07810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3K23_RS07815	COG0723	plastoquinol--plastocyanin reductase activity
C3K23_RS07820	COG2010	Cytochrome c
C3K23_RS07825	COG1845	cytochrome c oxidase, subunit III
C3K23_RS07835	COG1376	ErfK ybiS ycfS ynhG family protein
C3K23_RS07845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3K23_RS07850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3K23_RS07855	COG1104	cysteine desulfurase activity
C3K23_RS07860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K23_RS07885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3K23_RS07890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3K23_RS07895	COG2197	response regulator
C3K23_RS07940	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3K23_RS07950	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C3K23_RS07955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3K23_RS07960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3K23_RS07965	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3K23_RS07975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3K23_RS08025	COG0321	lipoyl(octanoyl) transferase activity
C3K23_RS08030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3K23_RS08065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3K23_RS08075	COG2376	Dihydroxyacetone kinase
C3K23_RS08085	COG2326	polyphosphate kinase activity
C3K23_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS08185	COG0745	RESPONSE REGULATOR receiver
C3K23_RS08210	COG1309	transcriptional regulator
C3K23_RS08230	COG0366	Alpha amylase catalytic
C3K23_RS08235	COG0395	ABC-type sugar transport system, permease component
C3K23_RS08240	COG1175	transmembrane transport
C3K23_RS08245	COG2182	Extracellular solute-binding protein
C3K23_RS08250	COG1609	Transcriptional regulator
C3K23_RS08280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3K23_RS08300	COG0174	glutamine synthetase
C3K23_RS08320	COG2132	Multicopper oxidase
C3K23_RS08325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3K23_RS08325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3K23_RS08335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3K23_RS08340	COG1994	Peptidase M50
C3K23_RS08390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS08395	COG1120	ATPase activity
C3K23_RS08415	COG1834	amidinotransferase
C3K23_RS08425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3K23_RS08430	COG2814	Major facilitator Superfamily
C3K23_RS08440	COG0076	glutamate decarboxylase activity
C3K23_RS08450	COG0300	oxidoreductase activity
C3K23_RS08455	COG0384	phenazine biosynthesis protein PhzF
C3K23_RS08515	COG3022	response to hydroperoxide
C3K23_RS08520	COG0800	Aldolase
C3K23_RS08535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3K23_RS08560	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS08570	COG0477	Major facilitator Superfamily
C3K23_RS08600	COG0438	transferase activity, transferring glycosyl groups
C3K23_RS08620	COG3845	ABC transporter
C3K23_RS08725	COG0586	Pfam SNARE associated Golgi protein
C3K23_RS08740	COG1358	cellular component organization or biogenesis
C3K23_RS08790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3K23_RS08810	COG4585	Histidine kinase
C3K23_RS08815	COG2197	response regulator
C3K23_RS08830	COG0667	Aldo Keto reductase
C3K23_RS08835	COG0789	Transcriptional regulator
C3K23_RS08845	COG1741	Belongs to the pirin family
C3K23_RS08860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3K23_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3K23_RS08870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3K23_RS08900	COG1764	response to oxidative stress
C3K23_RS08905	COG2130	NADP-dependent
C3K23_RS08930	COG1077	Cell shape determining protein MreB Mrl
C3K23_RS08945	COG2890	protein-(glutamine-N5) methyltransferase activity
C3K23_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS08965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3K23_RS08990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K23_RS09005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C3K23_RS09015	COG2851	Citrate transporter
C3K23_RS09020	COG4565	transcriptional regulatory protein
C3K23_RS09025	COG3290	protein histidine kinase activity
C3K23_RS09035	COG0358	DNA primase activity
C3K23_RS09040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3K23_RS09060	COG1070	Carbohydrate kinase
C3K23_RS09085	COG2226	methyltransferase
C3K23_RS09095	COG1324	tolerance protein
C3K23_RS09110	COG0574	Belongs to the PEP-utilizing enzyme family
C3K23_RS09110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3K23_RS09115	COG1846	Transcriptional regulator
C3K23_RS09115	COG1940	carbohydrate kinase activity
C3K23_RS09135	COG3467	pyridoxamine 5'-phosphate
C3K23_RS09210	COG0423	glycine-tRNA ligase activity
C3K23_RS09220	COG1121	(ABC) transporter
C3K23_RS09225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3K23_RS09235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3K23_RS09240	COG1381	Involved in DNA repair and RecF pathway recombination
C3K23_RS09250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3K23_RS09265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3K23_RS09275	COG2315	Protein conserved in bacteria
C3K23_RS09285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3K23_RS09305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K23_RS09310	COG1486	melibiose metabolic process
C3K23_RS09335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3K23_RS09340	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C3K23_RS09360	COG1234	tRNA 3'-trailer cleavage
C3K23_RS09365	COG0537	adenosine 5'-monophosphoramidase activity
C3K23_RS09370	COG4946	Tricorn protease homolog
C3K23_RS09370	COG0793	Belongs to the peptidase S41A family
C3K23_RS09385	COG0484	heat shock protein binding
C3K23_RS09415	COG0481	GTPase activity
C3K23_RS09420	COG0268	Binds directly to 16S ribosomal RNA
C3K23_RS09435	COG2353	YceI-like domain
C3K23_RS09450	COG1307	EDD domain protein, DegV family
C3K23_RS09460	COG0495	leucyl-tRNA aminoacylation
C3K23_RS09485	COG0588	phosphoglycerate mutase activity
C3K23_RS09490	COG0799	negative regulation of ribosome biogenesis
C3K23_RS09500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3K23_RS09505	COG0501	Belongs to the peptidase M48B family
C3K23_RS09525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3K23_RS09535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3K23_RS09555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3K23_RS09560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3K23_RS09565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3K23_RS09570	COG1530	ribonuclease E activity
C3K23_RS09600	COG0772	Belongs to the SEDS family
C3K23_RS09620	COG1077	Cell shape determining protein MreB Mrl
C3K23_RS09625	COG0105	UTP biosynthetic process
C3K23_RS09635	COG0285	dihydrofolate synthase activity
C3K23_RS09640	COG0525	valine-tRNA ligase activity
C3K23_RS09650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3K23_RS09655	COG0740	serine-type endopeptidase activity
C3K23_RS09660	COG0740	serine-type endopeptidase activity
C3K23_RS09665	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3K23_RS09685	COG3594	Acyltransferase
C3K23_RS09690	COG0475	glutathione-regulated potassium exporter activity
C3K23_RS09700	COG4552	Acetyltransferase involved in intracellular survival and related
C3K23_RS09715	COG1113	amino acid transport
C3K23_RS09720	COG1268	BioY protein
C3K23_RS09725	COG1113	amino acid transport
C3K23_RS09730	COG1113	amino acid transport
C3K23_RS09735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3K23_RS09740	COG0076	glutamate decarboxylase activity
C3K23_RS09745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3K23_RS09770	COG4266	Belongs to the allantoicase family
C3K23_RS09775	COG0583	DNA-binding transcription factor activity
C3K23_RS09785	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C3K23_RS09800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K23_RS09800	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C3K23_RS09815	COG3321	synthase
C3K23_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS09815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K23_RS09815	COG4221	oxidoreductase activity
C3K23_RS09825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K23_RS09850	COG1819	glycosyl
C3K23_RS09855	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS09860	COG0318	PFAM AMP-dependent synthetase and ligase
C3K23_RS09875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3K23_RS09885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3K23_RS09910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3K23_RS09930	COG3291	Pkd domain containing protein
C3K23_RS09930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3K23_RS09945	COG0668	transmembrane transport
C3K23_RS09955	COG1486	melibiose metabolic process
C3K23_RS09975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K23_RS10005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3K23_RS10010	COG0667	Aldo Keto reductase
C3K23_RS10030	COG1136	(ABC) transporter
C3K23_RS10105	COG0483	inositol monophosphate 1-phosphatase activity
C3K23_RS10135	COG3629	intracellular signal transduction
C3K23_RS10135	COG3903	Transcriptional regulator
C3K23_RS10165	COG1131	(ABC) transporter
C3K23_RS10185	COG3962	Belongs to the TPP enzyme family
C3K23_RS10190	COG3718	enzyme involved in inositol metabolism
C3K23_RS10230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3K23_RS10235	COG1472	Belongs to the glycosyl hydrolase 3 family
C3K23_RS10255	COG3960	tartronate-semialdehyde synthase activity
C3K23_RS10265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K23_RS10290	COG1946	Acyl-CoA thioesterase
C3K23_RS10300	COG1309	transcriptional regulator
C3K23_RS10305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3K23_RS10320	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS10355	COG3655	Transcriptional regulator
C3K23_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS10390	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C3K23_RS10415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3K23_RS10430	COG4977	sequence-specific DNA binding
C3K23_RS10435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C3K23_RS10485	COG0745	RESPONSE REGULATOR receiver
C3K23_RS10510	COG0406	alpha-ribazole phosphatase activity
C3K23_RS10625	COG0012	GTP binding
C3K23_RS10640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3K23_RS10650	COG1570	exodeoxyribonuclease VII activity
C3K23_RS10655	COG1722	exodeoxyribonuclease VII activity
C3K23_RS10660	COG0778	Nitroreductase
C3K23_RS10685	COG0515	serine threonine protein kinase
C3K23_RS10690	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C3K23_RS10690	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C3K23_RS10700	COG0114	fumarate hydratase activity
C3K23_RS10710	COG4106	trans-aconitate 2-methyltransferase activity
C3K23_RS10710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C3K23_RS10725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3K23_RS10745	COG1136	(ABC) transporter
C3K23_RS10755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3K23_RS10760	COG0450	alkyl hydroperoxide reductase
C3K23_RS10780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3K23_RS10785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3K23_RS10790	COG0667	Aldo Keto reductase
C3K23_RS10800	COG3548	integral membrane protein
C3K23_RS10815	COG0656	L-ascorbic acid biosynthetic process
C3K23_RS10820	COG2814	Major facilitator Superfamily
C3K23_RS10855	COG2197	response regulator
C3K23_RS10885	COG2894	cell division
C3K23_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS10940	COG0300	oxidoreductase activity
C3K23_RS10955	COG0251	oxidation-reduction process
C3K23_RS10960	COG1414	Transcriptional regulator
C3K23_RS10975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C3K23_RS11005	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3K23_RS11025	COG1331	Highly conserved protein containing a thioredoxin domain
C3K23_RS11075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3K23_RS11085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3K23_RS11120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3K23_RS11130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3K23_RS11145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3K23_RS11150	COG2255	four-way junction helicase activity
C3K23_RS11175	COG2318	DinB family
C3K23_RS11195	COG2986	histidine ammonia-lyase
C3K23_RS11205	COG1024	Enoyl-CoA hydratase
C3K23_RS11210	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3K23_RS11220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3K23_RS11230	COG0424	maF-like protein
C3K23_RS11240	COG4770	biotin carboxylase activity
C3K23_RS11275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3K23_RS11295	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS11320	COG1595	DNA-templated transcription, initiation
C3K23_RS11325	COG0745	RESPONSE REGULATOR receiver
C3K23_RS11330	COG2205	protein histidine kinase activity
C3K23_RS11355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3K23_RS11365	COG0583	DNA-binding transcription factor activity
C3K23_RS11370	COG2814	Major facilitator Superfamily
C3K23_RS11455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C3K23_RS11465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3K23_RS11465	COG1473	amidohydrolase
C3K23_RS11475	COG2089	acid synthase
C3K23_RS11480	COG1083	cytidylyl-transferase
C3K23_RS11490	COG1216	Glycosyl transferase, family 2
C3K23_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS11565	COG1595	DNA-templated transcription, initiation
C3K23_RS11570	COG1215	transferase activity, transferring glycosyl groups
C3K23_RS11610	COG2009	succinate dehydrogenase
C3K23_RS11620	COG1053	succinate dehydrogenase
C3K23_RS11625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3K23_RS11640	COG1309	transcriptional regulator
C3K23_RS11660	COG1937	Protein conserved in bacteria
C3K23_RS11670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3K23_RS11670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3K23_RS11685	COG0730	response to heat
C3K23_RS11710	COG1408	metallophosphoesterase
C3K23_RS11725	COG1295	ribonuclease BN
C3K23_RS11770	COG0180	Tryptophanyl-tRNA synthetase
C3K23_RS11800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3K23_RS11810	COG0754	glutathionylspermidine amidase activity
C3K23_RS11820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K23_RS11825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3K23_RS11855	COG0517	IMP dehydrogenase activity
C3K23_RS11855	COG4175	Glycine betaine
C3K23_RS11865	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS11885	COG0039	L-malate dehydrogenase activity
C3K23_RS11905	COG2197	response regulator
C3K23_RS11915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3K23_RS11925	COG0138	bifunctional purine biosynthesis protein purh
C3K23_RS11955	COG0045	succinate-CoA ligase (ADP-forming) activity
C3K23_RS11960	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C3K23_RS11965	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C3K23_RS11970	COG0714	Associated with various cellular activities
C3K23_RS11985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3K23_RS11985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3K23_RS11990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C3K23_RS11995	COG1196	nuclear chromosome segregation
C3K23_RS11995	COG0741	lytic transglycosylase activity
C3K23_RS11995	COG0739	heme binding
C3K23_RS12000	COG2066	Belongs to the glutaminase family
C3K23_RS12025	COG0791	NLP P60 protein
C3K23_RS12045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3K23_RS12105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C3K23_RS12110	COG2197	response regulator
C3K23_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS12145	COG0519	Catalyzes the synthesis of GMP from XMP
C3K23_RS12145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3K23_RS12165	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS12225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3K23_RS12235	COG0516	GMP reductase activity
C3K23_RS12245	COG1595	DNA-templated transcription, initiation
C3K23_RS12250	COG2197	response regulator
C3K23_RS12260	COG0583	DNA-binding transcription factor activity
C3K23_RS12265	COG4221	oxidoreductase activity
C3K23_RS12280	COG0726	polysaccharide deacetylase
C3K23_RS12315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3K23_RS12340	COG0802	atpase or kinase
C3K23_RS12350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3K23_RS12415	COG0736	holo-[acyl-carrier-protein] synthase activity
C3K23_RS12425	COG4977	sequence-specific DNA binding
C3K23_RS12435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3K23_RS12450	COG1072	(Pantothenic acid kinase))
C3K23_RS12455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3K23_RS12460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3K23_RS12465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3K23_RS12475	COG0101	tRNA pseudouridine synthase activity
C3K23_RS12480	COG0203	ribosomal protein L17
C3K23_RS12490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3K23_RS12495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3K23_RS12500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3K23_RS12505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3K23_RS12515	COG0563	adenylate kinase activity
C3K23_RS12520	COG0201	protein transport
C3K23_RS12525	COG0200	Binds to the 23S rRNA
C3K23_RS12530	COG1841	ribosomal large subunit assembly
C3K23_RS12535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3K23_RS12540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3K23_RS12545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3K23_RS12550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3K23_RS12560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3K23_RS12565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3K23_RS12570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3K23_RS12575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3K23_RS12580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3K23_RS12585	COG0255	Belongs to the universal ribosomal protein uL29 family
C3K23_RS12590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3K23_RS12595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3K23_RS12600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3K23_RS12605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3K23_RS12610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3K23_RS12615	COG0089	rRNA binding
C3K23_RS12620	COG0088	Forms part of the polypeptide exit tunnel
C3K23_RS12625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3K23_RS12630	COG0051	transcription antitermination factor activity, RNA binding
C3K23_RS12640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3K23_RS12660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3K23_RS12665	COG0049	tRNA binding
C3K23_RS12670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3K23_RS12705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3K23_RS12710	COG0085	RNA polymerase activity
C3K23_RS12715	COG0222	ribosome binding
C3K23_RS12720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3K23_RS12730	COG0081	regulation of translation
C3K23_RS12755	COG0436	Aminotransferase
C3K23_RS12760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3K23_RS12770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3K23_RS12780	COG2030	dehydratase
C3K23_RS12785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3K23_RS12800	COG0402	S-adenosylhomocysteine deaminase activity
C3K23_RS12805	COG0702	epimerase
C3K23_RS12845	COG2186	Transcriptional regulator
C3K23_RS12920	COG1666	GTP binding
C3K23_RS12925	COG2261	transglycosylase associated protein
C3K23_RS12930	COG3304	Inner membrane component domain
C3K23_RS12935	COG0501	Belongs to the peptidase M48B family
C3K23_RS12940	COG1007	ATP synthesis coupled electron transport
C3K23_RS12950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3K23_RS12955	COG0713	ATP synthesis coupled electron transport
C3K23_RS12960	COG0839	Belongs to the complex I subunit 6 family
C3K23_RS12965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS12970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3K23_RS12975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS12980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS12985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS12995	COG4585	Histidine kinase
C3K23_RS13000	COG2197	response regulator
C3K23_RS13005	COG0674	pyruvate-flavodoxin oxidoreductase activity
C3K23_RS13005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C3K23_RS13010	COG1013	pyruvate-flavodoxin oxidoreductase activity
C3K23_RS13015	COG1733	regulation of RNA biosynthetic process
C3K23_RS13020	COG0702	epimerase
C3K23_RS13030	COG0488	(ABC) transporter
C3K23_RS13055	COG3104	oligopeptide transport
C3K23_RS13075	COG0561	phosphatase activity
C3K23_RS13085	COG0514	ATP-dependent DNA helicase (RecQ)
C3K23_RS13090	COG1007	ATP synthesis coupled electron transport
C3K23_RS13100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3K23_RS13105	COG0713	ATP synthesis coupled electron transport
C3K23_RS13110	COG0839	Belongs to the complex I subunit 6 family
C3K23_RS13115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS13120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3K23_RS13125	COG1034	ATP synthesis coupled electron transport
C3K23_RS13130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3K23_RS13140	COG0649	NAD binding
C3K23_RS13145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS13150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS13175	COG2226	methyltransferase
C3K23_RS13185	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C3K23_RS13230	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C3K23_RS13340	COG1674	ftsk spoiiie
C3K23_RS13345	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C3K23_RS13360	COG0183	Belongs to the thiolase family
C3K23_RS13430	COG1301	dicarboxylic acid transport
C3K23_RS13445	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C3K23_RS13455	COG0163	prenyltransferase activity
C3K23_RS13460	COG0109	protoheme IX farnesyltransferase activity
C3K23_RS13465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C3K23_RS13480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3K23_RS13490	COG0785	Cytochrome C biogenesis protein
C3K23_RS13495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K23_RS13505	COG0406	alpha-ribazole phosphatase activity
C3K23_RS13510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3K23_RS13555	COG0659	secondary active sulfate transmembrane transporter activity
C3K23_RS13560	COG1690	Belongs to the RtcB family
C3K23_RS13585	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C3K23_RS13590	COG0018	arginyl-trna synthetase
C3K23_RS13595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K23_RS13615	COG0113	porphobilinogen synthase activity
C3K23_RS13620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3K23_RS13620	COG1648	precorrin-2 dehydrogenase activity
C3K23_RS13625	COG0181	hydroxymethylbilane synthase activity
C3K23_RS13630	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3K23_RS13635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3K23_RS13685	COG0123	including yeast histone deacetylase and acetoin utilization protein
C3K23_RS13690	COG2223	nitrite transmembrane transporter activity
C3K23_RS13715	COG0180	Tryptophanyl-tRNA synthetase
C3K23_RS13720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3K23_RS13730	COG0842	Transport permease protein
C3K23_RS13730	COG1129	ABC transporter
C3K23_RS13760	COG0129	dihydroxy-acid dehydratase activity
C3K23_RS13770	COG1082	Xylose isomerase domain protein TIM barrel
C3K23_RS13780	COG0248	Ppx GppA phosphatase
C3K23_RS13795	COG2801	Transposase and inactivated derivatives
C3K23_RS13795	COG3415	Transposase
C3K23_RS13820	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C3K23_RS13830	COG0671	phosphoesterase, PA-phosphatase related
C3K23_RS13840	COG1595	DNA-templated transcription, initiation
C3K23_RS13850	COG0745	RESPONSE REGULATOR receiver
C3K23_RS13855	COG2205	protein histidine kinase activity
C3K23_RS13860	COG0739	heme binding
C3K23_RS13885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C3K23_RS13905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3K23_RS13915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3K23_RS13920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3K23_RS13935	COG2197	response regulator
C3K23_RS13950	COG0649	NAD binding
C3K23_RS13970	COG2197	response regulator
C3K23_RS13975	COG4585	Histidine kinase
C3K23_RS13990	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS14065	COG0477	Major facilitator Superfamily
C3K23_RS14080	COG1174	glycine betaine transport
C3K23_RS14085	COG1174	glycine betaine transport
C3K23_RS14090	COG0517	IMP dehydrogenase activity
C3K23_RS14090	COG1125	glycine betaine transport
C3K23_RS14105	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3K23_RS14120	COG0302	gtp cyclohydrolase
C3K23_RS14135	COG0037	tRNA processing
C3K23_RS14145	COG2027	D-alanyl-D-alanine carboxypeptidase
C3K23_RS14150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3K23_RS14160	COG0586	Pfam SNARE associated Golgi protein
C3K23_RS14165	COG0789	Transcriptional regulator
C3K23_RS14170	COG0655	NAD(P)H dehydrogenase (quinone) activity
C3K23_RS14180	COG2318	DinB family
C3K23_RS14185	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS14210	COG1289	transmembrane transporter activity
C3K23_RS14235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3K23_RS14235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3K23_RS14255	COG0501	Belongs to the peptidase M48B family
C3K23_RS14295	COG0739	heme binding
C3K23_RS14300	COG0588	phosphoglycerate mutase activity
C3K23_RS14325	COG0438	transferase activity, transferring glycosyl groups
C3K23_RS14335	COG1388	LysM domain
C3K23_RS14335	COG3103	Sh3 type 3 domain protein
C3K23_RS14335	COG0791	NLP P60 protein
C3K23_RS14360	COG1309	transcriptional regulator
C3K23_RS14385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3K23_RS14460	COG0789	Transcriptional regulator
C3K23_RS14475	COG1490	D-aminoacyl-tRNA deacylase activity
C3K23_RS14480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3K23_RS14485	COG0735	belongs to the Fur family
C3K23_RS14490	COG3485	protocatechuate 3,4-dioxygenase
C3K23_RS14525	COG2897	thiosulfate sulfurtransferase activity
C3K23_RS14550	COG0745	RESPONSE REGULATOR receiver
C3K23_RS14555	COG1609	Transcriptional regulator
C3K23_RS14560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3K23_RS14565	COG0569	domain protein
C3K23_RS14570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3K23_RS14575	COG0745	RESPONSE REGULATOR receiver
C3K23_RS14590	COG4214	carbohydrate transport
C3K23_RS14595	COG1129	ABC transporter
C3K23_RS14605	COG1609	Transcriptional regulator
C3K23_RS14620	COG2160	L-arabinose isomerase activity
C3K23_RS14625	COG0235	Class ii aldolase
C3K23_RS14630	COG0737	Belongs to the 5'-nucleotidase family
C3K23_RS14635	COG0456	acetyltransferase
C3K23_RS14685	COG4941	Belongs to the sigma-70 factor family
C3K23_RS14690	COG1725	Transcriptional regulator
C3K23_RS14700	COG1131	(ABC) transporter
C3K23_RS14720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3K23_RS14800	COG3903	Transcriptional regulator
C3K23_RS14800	COG3629	intracellular signal transduction
C3K23_RS14805	COG0596	Alpha beta hydrolase
C3K23_RS14815	COG2770	Histidine kinase
C3K23_RS14815	COG2208	phosphoserine phosphatase activity
C3K23_RS14855	COG2318	DinB family
C3K23_RS14875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3K23_RS14900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3K23_RS14905	COG0306	phosphate transporter
C3K23_RS14915	COG1937	Protein conserved in bacteria
C3K23_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS14935	COG0671	phosphoesterase, PA-phosphatase related
C3K23_RS14940	COG1196	nuclear chromosome segregation
C3K23_RS14940	COG0739	heme binding
C3K23_RS14940	COG0741	lytic transglycosylase activity
C3K23_RS14965	COG2318	DinB family
C3K23_RS14975	COG0509	glycine decarboxylation via glycine cleavage system
C3K23_RS15025	COG2175	clavaminate synthase activity
C3K23_RS15030	COG3251	PFAM MbtH domain protein
C3K23_RS15035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3K23_RS15055	COG1136	(ABC) transporter
C3K23_RS15055	COG0577	efflux transmembrane transporter activity
C3K23_RS15095	COG2124	cytochrome p450
C3K23_RS15110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3K23_RS15125	COG1335	isochorismatase
C3K23_RS15130	COG2197	response regulator
C3K23_RS15135	COG4585	Histidine kinase
C3K23_RS15150	COG3844	kynureninase activity
C3K23_RS15170	COG0477	Major facilitator Superfamily
C3K23_RS15175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3K23_RS15180	COG0191	fructose-bisphosphate aldolase activity
C3K23_RS15185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3K23_RS15200	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C3K23_RS15240	COG0477	Major facilitator Superfamily
C3K23_RS15265	COG0789	Transcriptional regulator
C3K23_RS15270	COG0484	heat shock protein binding
C3K23_RS15275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3K23_RS15280	COG0443	Heat shock 70 kDa protein
C3K23_RS15315	COG1725	Transcriptional regulator
C3K23_RS15320	COG1131	(ABC) transporter
C3K23_RS15335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C3K23_RS15340	COG1120	ATPase activity
C3K23_RS15345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS15350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS15385	COG1695	Transcriptional regulator
C3K23_RS15395	COG2814	Major facilitator Superfamily
C3K23_RS15435	COG0717	Belongs to the dCTP deaminase family
C3K23_RS15465	COG0247	lactate metabolic process
C3K23_RS15465	COG2181	nitrate reductase activity
C3K23_RS15495	COG0477	Major facilitator Superfamily
C3K23_RS15505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K23_RS15535	COG2208	phosphoserine phosphatase activity
C3K23_RS15535	COG2770	Histidine kinase
C3K23_RS15540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C3K23_RS15545	COG1937	Protein conserved in bacteria
C3K23_RS15550	COG2268	Band 7 protein
C3K23_RS15565	COG1316	TRANSCRIPTIONal
C3K23_RS15600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K23_RS15610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3K23_RS15625	COG1741	Belongs to the pirin family
C3K23_RS15635	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS15655	COG1362	aminopeptidase activity
C3K23_RS15695	COG2271	Major facilitator Superfamily
C3K23_RS15710	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3K23_RS15715	COG0022	dehydrogenase e1 component
C3K23_RS15730	COG0515	serine threonine protein kinase
C3K23_RS15735	COG0515	serine threonine protein kinase
C3K23_RS15760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3K23_RS15765	COG0303	'Molybdopterin
C3K23_RS15790	COG1522	sequence-specific DNA binding
C3K23_RS15830	COG1733	regulation of RNA biosynthetic process
C3K23_RS15835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3K23_RS15845	COG1716	ATPase activity
C3K23_RS15850	COG1716	ATPase activity
C3K23_RS15870	COG0515	serine threonine protein kinase
C3K23_RS15875	COG3764	Sortase (surface protein transpeptidase)
C3K23_RS15880	COG3764	Sortase (surface protein transpeptidase)
C3K23_RS15900	COG0705	Rhomboid family
C3K23_RS15925	COG1278	Cold shock
C3K23_RS15955	COG0515	serine threonine protein kinase
C3K23_RS15995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3K23_RS16000	COG0187	DNA topoisomerase II activity
C3K23_RS16005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C3K23_RS16010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3K23_RS16015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C3K23_RS16020	COG0592	DNA-directed DNA polymerase activity
C3K23_RS16025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3K23_RS16030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3K23_RS16035	COG0594	ribonuclease P activity
C3K23_RS16040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3K23_RS16045	COG0706	membrane insertase activity
C3K23_RS16055	COG0357	Ribosomal RNA small subunit methyltransferase G
C3K23_RS16060	COG1192	Involved in chromosome partitioning
C3K23_RS16075	COG3118	belongs to the thioredoxin family
C3K23_RS16080	COG0492	ferredoxin-NADP+ reductase activity
C3K23_RS16090	COG1595	DNA-templated transcription, initiation
C3K23_RS16095	COG0515	serine threonine protein kinase
C3K23_RS16095	COG2815	serine threonine protein kinase
C3K23_RS16110	COG0617	tRNA 3'-terminal CCA addition
C3K23_RS16135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3K23_RS16160	COG0360	Binds together with S18 to 16S ribosomal RNA
C3K23_RS16165	COG0629	single-stranded DNA binding
C3K23_RS16170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3K23_RS16175	COG0359	binds to the 23S rRNA
C3K23_RS16185	COG0305	Participates in initiation and elongation during chromosome replication
C3K23_RS16240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3K23_RS16245	COG0110	maltose O-acetyltransferase activity
C3K23_RS16260	COG0456	acetyltransferase
C3K23_RS16285	COG0626	cystathionine gamma-synthase activity
C3K23_RS16290	COG1950	PFAM Membrane protein of
C3K23_RS16295	COG0662	Cupin 2, conserved barrel domain protein
C3K23_RS16320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3K23_RS16335	COG1609	Transcriptional regulator
C3K23_RS16340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3K23_RS16345	COG1271	oxidase subunit
C3K23_RS16350	COG1294	oxidase, subunit
C3K23_RS16355	COG4988	ABC transporter
C3K23_RS16370	COG0561	phosphatase activity
C3K23_RS16390	COG1131	(ABC) transporter
C3K23_RS16410	COG0561	phosphatase activity
C3K23_RS16415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3K23_RS16420	COG0077	Prephenate dehydratase
C3K23_RS16425	COG2837	iron assimilation
C3K23_RS16440	COG1999	signal sequence binding
C3K23_RS16460	COG0006	proline dipeptidase activity
C3K23_RS16475	COG0653	protein targeting
C3K23_RS16490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3K23_RS16510	COG1595	DNA-templated transcription, initiation
C3K23_RS16515	COG0318	PFAM AMP-dependent synthetase and ligase
C3K23_RS16550	COG0745	RESPONSE REGULATOR receiver
C3K23_RS16560	COG0477	Major facilitator Superfamily
C3K23_RS16580	COG0477	Major facilitator Superfamily
C3K23_RS16595	COG1191	sigma factor activity
C3K23_RS16600	COG1191	sigma factor activity
C3K23_RS16630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3K23_RS16690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3K23_RS16715	COG0151	Belongs to the GarS family
C3K23_RS16730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3K23_RS16740	COG2197	response regulator
C3K23_RS16775	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3K23_RS16780	COG0047	phosphoribosylformylglycinamidine synthase activity
C3K23_RS16785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3K23_RS16800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3K23_RS16835	COG1643	Atp-dependent helicase
C3K23_RS16870	COG0513	Belongs to the DEAD box helicase family
C3K23_RS16900	COG0542	response to heat
C3K23_RS16910	COG2261	transglycosylase associated protein
C3K23_RS16930	COG0667	Aldo Keto reductase
C3K23_RS16940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3K23_RS16945	COG0579	oxidoreductase
C3K23_RS16960	COG1470	cell adhesion involved in biofilm formation
C3K23_RS16960	COG0366	Alpha amylase catalytic
C3K23_RS17045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3K23_RS17055	COG2197	response regulator
C3K23_RS17060	COG4585	Histidine kinase
C3K23_RS17070	COG0666	response to abiotic stimulus
C3K23_RS17140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3K23_RS17145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3K23_RS17155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3K23_RS17225	COG2318	DinB family
C3K23_RS17240	COG1136	(ABC) transporter
C3K23_RS17240	COG0577	efflux transmembrane transporter activity
C3K23_RS17260	COG1408	metallophosphoesterase
C3K23_RS17280	COG0003	Pfam Anion-transporting ATPase
C3K23_RS17290	COG0251	oxidation-reduction process
C3K23_RS17300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K23_RS17330	COG2267	carboxylic ester hydrolase activity
C3K23_RS17340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3K23_RS17345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3K23_RS17350	COG0659	secondary active sulfate transmembrane transporter activity
C3K23_RS17410	COG1205	dead DEAH box helicase
C3K23_RS17410	COG1111	helicase
C3K23_RS17415	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K23_RS17430	COG2890	protein-(glutamine-N5) methyltransferase activity
C3K23_RS17440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3K23_RS17440	COG1754	DNA topoisomerase type I activity
C3K23_RS17445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3K23_RS17520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3K23_RS17670	COG1609	Transcriptional regulator
C3K23_RS17675	COG2182	Extracellular solute-binding protein
C3K23_RS17680	COG1175	transmembrane transport
C3K23_RS17685	COG0395	ABC-type sugar transport system, permease component
C3K23_RS17690	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS17875	COG2072	flavoprotein involved in K transport
C3K23_RS17880	COG0640	Transcriptional regulator
C3K23_RS17890	COG2072	flavoprotein involved in K transport
C3K23_RS17895	COG0798	PFAM Bile acid sodium symporter
C3K23_RS17900	COG0640	Transcriptional regulator
C3K23_RS17910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3K23_RS17925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3K23_RS17955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3K23_RS17965	COG0398	Pfam SNARE associated Golgi protein
C3K23_RS17975	COG2226	methyltransferase
C3K23_RS18100	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS18110	COG0789	Transcriptional regulator
C3K23_RS18120	COG0596	Alpha beta hydrolase
C3K23_RS18135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3K23_RS18165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3K23_RS18165	COG0825	malonyl-CoA metabolic process
C3K23_RS18180	COG2186	Transcriptional regulator
C3K23_RS18195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3K23_RS18205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C3K23_RS18230	COG1252	NADH dehydrogenase
C3K23_RS18245	COG0640	Transcriptional regulator
C3K23_RS18255	COG1316	TRANSCRIPTIONal
C3K23_RS18260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3K23_RS18285	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C3K23_RS18320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS18325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C3K23_RS18330	COG0783	Belongs to the Dps family
C3K23_RS18335	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C3K23_RS18350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C3K23_RS18365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3K23_RS18370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3K23_RS18390	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3K23_RS18420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3K23_RS18490	COG2076	Multidrug Resistance protein
C3K23_RS18500	COG5002	protein histidine kinase activity
C3K23_RS18505	COG0745	RESPONSE REGULATOR receiver
C3K23_RS18520	COG1329	Transcriptional regulator
C3K23_RS18525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3K23_RS18530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3K23_RS18550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K23_RS18565	COG0215	cysteine-tRNA ligase activity
C3K23_RS18580	COG1253	flavin adenine dinucleotide binding
C3K23_RS18590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3K23_RS18600	COG3842	ATPase activity
C3K23_RS18625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3K23_RS18650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K23_RS18655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3K23_RS18660	COG1834	amidinotransferase
C3K23_RS18675	COG0475	glutathione-regulated potassium exporter activity
C3K23_RS18680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3K23_RS18685	COG0477	Major facilitator Superfamily
C3K23_RS18700	COG4977	sequence-specific DNA binding
C3K23_RS18705	COG0531	amino acid
C3K23_RS18745	COG1309	transcriptional regulator
C3K23_RS18780	COG2770	Histidine kinase
C3K23_RS18780	COG2208	phosphoserine phosphatase activity
C3K23_RS18810	COG1278	Cold shock
C3K23_RS18815	COG0513	Belongs to the DEAD box helicase family
C3K23_RS18835	COG0301	tRNA thio-modification
C3K23_RS18850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3K23_RS18855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3K23_RS18860	COG2197	response regulator
C3K23_RS18865	COG4585	Histidine kinase
C3K23_RS18890	COG0577	efflux transmembrane transporter activity
C3K23_RS18895	COG1136	(ABC) transporter
C3K23_RS18895	COG0577	efflux transmembrane transporter activity
C3K23_RS18920	COG2172	sigma factor antagonist activity
C3K23_RS18925	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K23_RS18930	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K23_RS19045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3K23_RS19080	COG0577	efflux transmembrane transporter activity
C3K23_RS19080	COG1136	(ABC) transporter
C3K23_RS19095	COG1309	transcriptional regulator
C3K23_RS19120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3K23_RS19145	COG1105	Belongs to the carbohydrate kinase PfkB family
C3K23_RS19160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3K23_RS19240	COG0463	Glycosyl transferase, family 2
C3K23_RS19255	COG1278	Cold shock
C3K23_RS19280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K23_RS19290	COG0667	Aldo Keto reductase
C3K23_RS19295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K23_RS19295	COG1263	PTS System
C3K23_RS19300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C3K23_RS19305	COG1737	Transcriptional regulator
C3K23_RS19310	COG0406	alpha-ribazole phosphatase activity
C3K23_RS19360	COG3973	AAA domain
C3K23_RS19425	COG1061	Type III restriction enzyme res subunit
C3K23_RS19470	COG2124	cytochrome p450
C3K23_RS19480	COG1295	ribonuclease BN
C3K23_RS19495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS19500	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS19505	COG1120	ATPase activity
C3K23_RS19510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3K23_RS19515	COG0515	serine threonine protein kinase
C3K23_RS19525	COG1132	(ABC) transporter
C3K23_RS19535	COG2197	response regulator
C3K23_RS19545	COG1278	Cold shock
C3K23_RS19550	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C3K23_RS19555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3K23_RS19565	COG2814	Major facilitator Superfamily
C3K23_RS19590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3K23_RS19600	COG2252	PERMEase
C3K23_RS19625	COG0667	Aldo Keto reductase
C3K23_RS19655	COG3293	Transposase
C3K23_RS19750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C3K23_RS19760	COG2124	cytochrome p450
C3K23_RS19780	COG2205	protein histidine kinase activity
C3K23_RS19785	COG0277	FAD linked oxidase domain protein
C3K23_RS19785	COG0247	lactate metabolic process
C3K23_RS19795	COG0583	DNA-binding transcription factor activity
C3K23_RS19825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3K23_RS19840	COG1024	Enoyl-CoA hydratase
C3K23_RS19860	COG0259	pyridoxamine-phosphate oxidase activity
C3K23_RS19870	COG4821	SIS domain
C3K23_RS19950	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K23_RS19970	COG2072	flavoprotein involved in K transport
C3K23_RS19995	COG1309	transcriptional regulator
C3K23_RS20000	COG0515	serine threonine protein kinase
C3K23_RS20000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3K23_RS20050	COG0477	Major facilitator Superfamily
C3K23_RS20060	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS20065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3K23_RS20085	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3K23_RS20095	COG0366	Alpha amylase catalytic
C3K23_RS20140	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C3K23_RS20170	COG5297	Belongs to the glycosyl hydrolase family 6
C3K23_RS20245	COG1278	Cold shock
C3K23_RS20290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3K23_RS20295	COG2151	metal-sulfur cluster biosynthetic enzyme
C3K23_RS20300	COG3396	Phenylacetate-CoA oxygenase
C3K23_RS20305	COG3460	Phenylacetate-CoA oxygenase
C3K23_RS20310	COG3396	Phenylacetate-CoA oxygenase
C3K23_RS20315	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS20320	COG1024	Enoyl-CoA hydratase
C3K23_RS20325	COG0183	Belongs to the thiolase family
C3K23_RS20335	COG2050	protein possibly involved in aromatic compounds catabolism
C3K23_RS20390	COG1846	Transcriptional regulator
C3K23_RS20395	COG3384	dioxygenase
C3K23_RS20415	COG3191	aminopeptidase activity
C3K23_RS20425	COG1970	mechanosensitive ion channel activity
C3K23_RS20435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C3K23_RS20450	COG3263	regulation of cellular component size
C3K23_RS20460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3K23_RS20465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3K23_RS20475	COG0315	cyclic pyranopterin monophosphate synthase activity
C3K23_RS20480	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3K23_RS20520	COG2197	response regulator
C3K23_RS20540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3K23_RS20550	COG0708	Exodeoxyribonuclease III
C3K23_RS20560	COG2072	flavoprotein involved in K transport
C3K23_RS20570	COG4221	oxidoreductase activity
C3K23_RS20580	COG4946	Tricorn protease homolog
C3K23_RS20580	COG0793	Belongs to the peptidase S41A family
C3K23_RS20590	COG2409	Drug exporters of the RND superfamily
C3K23_RS20660	COG0084	hydrolase, TatD family'
C3K23_RS20665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3K23_RS20670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3K23_RS20675	COG0488	(ABC) transporter
C3K23_RS20720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3K23_RS20725	COG2197	response regulator
C3K23_RS20735	COG4106	trans-aconitate 2-methyltransferase activity
C3K23_RS20755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C3K23_RS20765	COG0193	aminoacyl-tRNA hydrolase activity
C3K23_RS20770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3K23_RS20795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3K23_RS20800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3K23_RS20810	COG4585	Histidine kinase
C3K23_RS20835	COG0789	Transcriptional regulator
C3K23_RS20855	COG1316	TRANSCRIPTIONal
C3K23_RS20865	COG2267	carboxylic ester hydrolase activity
C3K23_RS20890	COG0477	Major facilitator Superfamily
C3K23_RS20900	COG3903	Transcriptional regulator
C3K23_RS20900	COG3629	intracellular signal transduction
C3K23_RS20955	COG1473	amidohydrolase
C3K23_RS20965	COG3226	Transcriptional regulator
C3K23_RS20970	COG0154	amidase activity
C3K23_RS21010	COG1733	regulation of RNA biosynthetic process
C3K23_RS21050	COG2124	cytochrome p450
C3K23_RS21065	COG0148	phosphopyruvate hydratase activity
C3K23_RS21095	COG1252	NADH dehydrogenase
C3K23_RS21100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3K23_RS21105	COG0577	efflux transmembrane transporter activity
C3K23_RS21105	COG1136	(ABC) transporter
C3K23_RS21110	COG1136	(ABC) transporter
C3K23_RS21135	COG1476	TRANSCRIPTIONal
C3K23_RS21160	COG0183	Belongs to the thiolase family
C3K23_RS21165	COG2755	lipolytic protein G-D-S-L family
C3K23_RS21225	COG0395	ABC-type sugar transport system, permease component
C3K23_RS21255	COG1228	amidohydrolase
C3K23_RS21260	COG1191	sigma factor activity
C3K23_RS21265	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K23_RS21275	COG3104	oligopeptide transport
C3K23_RS21280	COG0745	RESPONSE REGULATOR receiver
C3K23_RS21285	COG2205	protein histidine kinase activity
C3K23_RS21325	COG2072	flavoprotein involved in K transport
C3K23_RS21335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3K23_RS21345	COG0753	catalase activity
C3K23_RS21350	COG3046	protein related to deoxyribodipyrimidine photolyase
C3K23_RS21355	COG1316	TRANSCRIPTIONal
C3K23_RS21365	COG1316	TRANSCRIPTIONal
C3K23_RS21375	COG1316	TRANSCRIPTIONal
C3K23_RS21405	COG0778	Nitroreductase
C3K23_RS21405	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C3K23_RS21410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C3K23_RS21445	COG1620	l-lactate permease
C3K23_RS21450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3K23_RS21460	COG2835	tetraacyldisaccharide 4'-kinase activity
C3K23_RS21470	COG1482	cell wall glycoprotein biosynthetic process
C3K23_RS21480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C3K23_RS21535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C3K23_RS21540	COG0745	RESPONSE REGULATOR receiver
C3K23_RS21545	COG5002	protein histidine kinase activity
C3K23_RS21550	COG0823	Involved in the tonB-independent uptake of proteins
C3K23_RS21560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3K23_RS21565	COG2197	response regulator
C3K23_RS21570	COG3214	Protein conserved in bacteria
C3K23_RS21575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K23_RS21580	COG0653	protein targeting
C3K23_RS21610	COG0583	DNA-binding transcription factor activity
C3K23_RS21630	COG2902	Dehydrogenase
C3K23_RS21655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3K23_RS21660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3K23_RS21665	COG0438	transferase activity, transferring glycosyl groups
C3K23_RS21670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3K23_RS21675	COG0395	ABC-type sugar transport system, permease component
C3K23_RS21690	COG1716	ATPase activity
C3K23_RS21695	COG0515	serine threonine protein kinase
C3K23_RS21700	COG0515	serine threonine protein kinase
C3K23_RS21705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3K23_RS21720	COG2884	Cell division ATP-binding protein ftsE
C3K23_RS21730	COG0793	Belongs to the peptidase S41A family
C3K23_RS21735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3K23_RS21750	COG0583	DNA-binding transcription factor activity
C3K23_RS21795	COG3973	AAA domain
C3K23_RS21795	COG3973	AAA domain
C3K23_RS21805	COG0776	regulation of translation
C3K23_RS21810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3K23_RS21815	COG1678	Uncharacterized ACR, COG1678
C3K23_RS21835	COG0395	ABC-type sugar transport system, permease component
C3K23_RS21840	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3K23_RS21855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3K23_RS21875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3K23_RS21900	COG2318	DinB family
C3K23_RS21910	COG1136	(ABC) transporter
C3K23_RS21945	COG1174	glycine betaine transport
C3K23_RS21950	COG0517	IMP dehydrogenase activity
C3K23_RS21950	COG1125	glycine betaine transport
C3K23_RS21955	COG1174	glycine betaine transport
C3K23_RS21965	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C3K23_RS21975	COG0277	FAD linked oxidase domain protein
C3K23_RS22010	COG1335	isochorismatase
C3K23_RS22020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3K23_RS22035	COG1113	amino acid transport
C3K23_RS22055	COG1234	tRNA 3'-trailer cleavage
C3K23_RS22065	COG1263	PTS System
C3K23_RS22070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K23_RS22075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3K23_RS22085	COG1131	(ABC) transporter
C3K23_RS22095	COG3851	Histidine kinase
C3K23_RS22100	COG2197	response regulator
C3K23_RS22105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3K23_RS22130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3K23_RS22140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3K23_RS22170	COG2733	membrane
C3K23_RS22200	COG0706	membrane insertase activity
C3K23_RS22205	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3K23_RS22210	COG0673	inositol 2-dehydrogenase activity
C3K23_RS22265	COG3397	chitin binding
C3K23_RS22285	COG1126	abc transporter atp-binding protein
C3K23_RS22290	COG0765	amino acid transport
C3K23_RS22295	COG0765	amino acid transport
C3K23_RS22300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K23_RS22330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K23_RS22335	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS22455	COG0601	transmembrane transport
C3K23_RS22460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K23_RS22465	COG0444	Belongs to the ABC transporter superfamily
C3K23_RS22470	COG4608	Belongs to the ABC transporter superfamily
C3K23_RS22480	COG0601	transmembrane transport
C3K23_RS22485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K23_RS22495	COG4608	Belongs to the ABC transporter superfamily
C3K23_RS22520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3K23_RS22550	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3K23_RS22555	COG1609	Transcriptional regulator
C3K23_RS22565	COG2912	Transglutaminase-like superfamily
C3K23_RS22570	COG0456	acetyltransferase
C3K23_RS22600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K23_RS22610	COG2207	Transcriptional regulator
C3K23_RS22635	COG0519	Catalyzes the synthesis of GMP from XMP
C3K23_RS22645	COG1024	Enoyl-CoA hydratase
C3K23_RS22660	COG1595	DNA-templated transcription, initiation
C3K23_RS22670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3K23_RS22675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3K23_RS22715	COG0598	Magnesium transport protein CorA
C3K23_RS22730	COG2814	Major facilitator Superfamily
C3K23_RS22735	COG0613	PHP domain protein
C3K23_RS22740	COG2095	MarC family integral membrane protein
C3K23_RS22745	COG1432	Conserved Protein
C3K23_RS22755	COG0513	Belongs to the DEAD box helicase family
C3K23_RS22850	COG0210	DNA helicase
C3K23_RS22855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K23_RS22890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3K23_RS22945	COG3480	Lon protease (S16) C-terminal proteolytic domain
C3K23_RS22955	COG1615	UPF0182 protein
C3K23_RS22980	COG0753	catalase activity
C3K23_RS22985	COG0483	inositol monophosphate 1-phosphatase activity
C3K23_RS22995	COG2076	Multidrug Resistance protein
C3K23_RS23005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3K23_RS23015	COG2135	peptidase activity
C3K23_RS23025	COG1595	DNA-templated transcription, initiation
C3K23_RS23030	COG5662	AntiSigma factor
C3K23_RS23040	COG0242	peptide deformylase activity
C3K23_RS23050	COG2124	cytochrome p450
C3K23_RS23070	COG1966	Carbon starvation protein
C3K23_RS23075	COG2188	Transcriptional regulator
C3K23_RS23080	COG2182	Extracellular solute-binding protein
C3K23_RS23085	COG1175	transmembrane transport
C3K23_RS23090	COG0395	ABC-type sugar transport system, permease component
C3K23_RS23095	COG1472	Belongs to the glycosyl hydrolase 3 family
C3K23_RS23100	COG0363	glucosamine-6-phosphate deaminase activity
C3K23_RS23115	COG1597	lipid kinase activity
C3K23_RS23130	COG2172	sigma factor antagonist activity
C3K23_RS23145	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C3K23_RS23165	COG1959	2 iron, 2 sulfur cluster binding
C3K23_RS23170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3K23_RS23225	COG4106	trans-aconitate 2-methyltransferase activity
C3K23_RS23230	COG1126	abc transporter atp-binding protein
C3K23_RS23240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K23_RS23245	COG0281	malic enzyme
C3K23_RS23250	COG0604	alcohol dehydrogenase
C3K23_RS23290	COG2255	four-way junction helicase activity
C3K23_RS23320	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3K23_RS23320	COG0567	Dehydrogenase, E1 component
C3K23_RS23325	COG2205	protein histidine kinase activity
C3K23_RS23330	COG0745	RESPONSE REGULATOR receiver
C3K23_RS23350	COG1131	(ABC) transporter
C3K23_RS23360	COG1595	DNA-templated transcription, initiation
C3K23_RS23375	COG0477	Major facilitator Superfamily
C3K23_RS23380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3K23_RS23385	COG0726	polysaccharide deacetylase
C3K23_RS23455	COG0768	penicillin binding
C3K23_RS23460	COG0772	Belongs to the SEDS family
C3K23_RS23475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3K23_RS23480	COG2267	carboxylic ester hydrolase activity
C3K23_RS23490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3K23_RS23490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3K23_RS23495	COG1191	sigma factor activity
C3K23_RS23505	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS23520	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS23545	COG0018	arginyl-trna synthetase
C3K23_RS23550	COG0019	diaminopimelate decarboxylase activity
C3K23_RS23555	COG0460	homoserine dehydrogenase
C3K23_RS23560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3K23_RS23565	COG0083	homoserine kinase activity
C3K23_RS23575	COG1316	TRANSCRIPTIONal
C3K23_RS23580	COG0254	rRNA binding
C3K23_RS23585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3K23_RS23590	COG2890	protein-(glutamine-N5) methyltransferase activity
C3K23_RS23600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3K23_RS23605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3K23_RS23620	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3K23_RS23625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3K23_RS23630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3K23_RS23635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3K23_RS23640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3K23_RS23645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3K23_RS23650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3K23_RS23670	COG2197	response regulator
C3K23_RS23675	COG4585	Histidine kinase
C3K23_RS23690	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS23705	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C3K23_RS23740	COG1131	(ABC) transporter
C3K23_RS23760	COG0183	Belongs to the thiolase family
C3K23_RS23785	COG2205	protein histidine kinase activity
C3K23_RS23790	COG1335	isochorismatase
C3K23_RS23830	COG2945	thiolester hydrolase activity
C3K23_RS23830	COG0596	Alpha beta hydrolase
C3K23_RS23860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3K23_RS23860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3K23_RS23905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3K23_RS23910	COG0280	phosphate acetyltransferase
C3K23_RS23910	COG0857	belongs to the CobB CobQ family
C3K23_RS23915	COG0205	6-phosphofructokinase activity
C3K23_RS23920	COG4565	transcriptional regulatory protein
C3K23_RS23925	COG3290	protein histidine kinase activity
C3K23_RS23930	COG1301	dicarboxylic acid transport
C3K23_RS23945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3K23_RS23965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3K23_RS23970	COG3281	Trehalose synthase
C3K23_RS23975	COG0366	Alpha amylase catalytic
C3K23_RS23980	COG0366	Alpha amylase catalytic
C3K23_RS24000	COG3629	intracellular signal transduction
C3K23_RS24000	COG3903	Transcriptional regulator
C3K23_RS24010	COG1132	(ABC) transporter
C3K23_RS24015	COG1132	(ABC) transporter
C3K23_RS24040	COG1376	ErfK ybiS ycfS ynhG family protein
C3K23_RS24065	COG2085	NADP oxidoreductase coenzyme F420-dependent
C3K23_RS24090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3K23_RS24105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C3K23_RS24110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C3K23_RS24115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C3K23_RS24130	COG1760	l-serine dehydratase
C3K23_RS24135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3K23_RS24140	COG0509	glycine decarboxylation via glycine cleavage system
C3K23_RS24145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3K23_RS24165	COG4166	transmembrane transport
C3K23_RS24180	COG0444	Belongs to the ABC transporter superfamily
C3K23_RS24185	COG4608	Belongs to the ABC transporter superfamily
C3K23_RS24190	COG2860	membrane
C3K23_RS24215	COG0482	sulfurtransferase activity
C3K23_RS24235	COG4221	oxidoreductase activity
C3K23_RS24245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3K23_RS24255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3K23_RS24260	COG0154	amidase activity
C3K23_RS24270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3K23_RS24275	COG2409	Drug exporters of the RND superfamily
C3K23_RS24290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3K23_RS24290	COG1672	PFAM Archaeal ATPase
C3K23_RS24295	COG2133	pyrroloquinoline quinone binding
C3K23_RS24300	COG0667	Aldo Keto reductase
C3K23_RS24320	COG0440	acetolactate synthase activity
C3K23_RS24325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3K23_RS24335	COG2890	protein-(glutamine-N5) methyltransferase activity
C3K23_RS24355	COG3835	regulator
C3K23_RS24360	COG0506	proline dehydrogenase activity
C3K23_RS24365	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS24380	COG0575	Belongs to the CDS family
C3K23_RS24390	COG0473	3-isopropylmalate dehydrogenase activity
C3K23_RS24395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3K23_RS24400	COG0831	urea catabolic process
C3K23_RS24400	COG0832	Belongs to the urease beta subunit family
C3K23_RS24405	COG0804	urea catabolic process
C3K23_RS24410	COG2957	Belongs to the agmatine deiminase family
C3K23_RS24420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3K23_RS24460	COG0789	Transcriptional regulator
C3K23_RS24480	COG2353	YceI-like domain
C3K23_RS24490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3K23_RS24510	COG2018	Roadblock/LC7 domain
C3K23_RS24530	COG2018	Roadblock/LC7 domain
C3K23_RS24545	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3K23_RS24550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3K23_RS24585	COG0789	Transcriptional regulator
C3K23_RS24595	COG1414	Transcriptional regulator
C3K23_RS24600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3K23_RS24605	COG0066	3-isopropylmalate dehydratase activity
C3K23_RS24615	COG0776	regulation of translation
C3K23_RS24625	COG1920	GTP binding
C3K23_RS24635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3K23_RS24640	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3K23_RS24660	COG0351	phosphomethylpyrimidine kinase
C3K23_RS24665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3K23_RS24670	COG1461	Dihydroxyacetone kinase
C3K23_RS24680	COG0742	ribosomal rna small subunit methyltransferase
C3K23_RS24685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3K23_RS24700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3K23_RS24705	COG0571	ribonuclease III activity
C3K23_RS24710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3K23_RS24715	COG2340	Cysteine-rich secretory protein family
C3K23_RS24720	COG1254	Belongs to the acylphosphatase family
C3K23_RS24730	COG1196	nuclear chromosome segregation
C3K23_RS24735	COG0477	Major facilitator Superfamily
C3K23_RS24765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C3K23_RS24775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3K23_RS24790	COG0228	four-way junction DNA binding
C3K23_RS24795	COG1837	Belongs to the UPF0109 family
C3K23_RS24800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3K23_RS24805	COG0336	Belongs to the RNA methyltransferase TrmD family
C3K23_RS24810	COG0335	large ribosomal subunit rRNA binding
C3K23_RS24815	COG0681	Belongs to the peptidase S26 family
C3K23_RS24825	COG0681	Belongs to the peptidase S26 family
C3K23_RS24830	COG0681	Belongs to the peptidase S26 family
C3K23_RS24845	COG0792	nuclease activity
C3K23_RS24860	COG1191	sigma factor activity
C3K23_RS24870	COG1388	LysM domain
C3K23_RS24870	COG4942	peptidase
C3K23_RS24875	COG0052	Belongs to the universal ribosomal protein uS2 family
C3K23_RS24880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3K23_RS24885	COG0528	UMP kinase activity
C3K23_RS24890	COG0233	cytoplasmic translational termination
C3K23_RS24900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3K23_RS24915	COG3842	ATPase activity
C3K23_RS24940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3K23_RS24950	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS24965	COG0584	glycerophosphoryl diester phosphodiesterase
C3K23_RS24970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3K23_RS24985	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS24995	COG3842	ATPase activity
C3K23_RS25000	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3K23_RS25005	COG1177	transmembrane transport
C3K23_RS25010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3K23_RS25040	COG2508	Transcriptional regulator
C3K23_RS25045	COG1012	belongs to the aldehyde dehydrogenase family
C3K23_RS25050	COG1940	carbohydrate kinase activity
C3K23_RS25055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3K23_RS25060	COG0750	zinc metalloprotease
C3K23_RS25065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3K23_RS25080	COG0747	negative chemotaxis
C3K23_RS25085	COG0601	transmembrane transport
C3K23_RS25110	COG0442	prolyl-tRNA aminoacylation
C3K23_RS25130	COG0779	Required for maturation of 30S ribosomal subunits
C3K23_RS25145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3K23_RS25155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3K23_RS25160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3K23_RS25175	COG1357	PFAM Pentapeptide repeats (8 copies)
C3K23_RS25180	COG4608	Belongs to the ABC transporter superfamily
C3K23_RS25185	COG0444	Belongs to the ABC transporter superfamily
C3K23_RS25190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K23_RS25195	COG0601	transmembrane transport
C3K23_RS25200	COG4166	transmembrane transport
C3K23_RS25205	COG0455	bacterial-type flagellum organization
C3K23_RS25215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3K23_RS25220	COG1185	polyribonucleotide nucleotidyltransferase activity
C3K23_RS25225	COG0612	Peptidase, M16
C3K23_RS25230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3K23_RS25250	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C3K23_RS25255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3K23_RS25260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3K23_RS25280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3K23_RS25290	COG2770	Histidine kinase
C3K23_RS25290	COG2208	phosphoserine phosphatase activity
C3K23_RS25300	COG2205	protein histidine kinase activity
C3K23_RS25300	COG4999	Histidine kinase
C3K23_RS25300	COG3850	Histidine kinase
C3K23_RS25300	COG3437	response regulator, receiver
C3K23_RS25310	COG1674	ftsk spoiiie
C3K23_RS25320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3K23_RS25330	COG1546	Belongs to the CinA family
C3K23_RS25330	COG1058	Belongs to the CinA family
C3K23_RS25335	COG1396	sequence-specific DNA binding
C3K23_RS25340	COG0783	Belongs to the Dps family
C3K23_RS25350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3K23_RS25370	COG0596	Alpha beta hydrolase
C3K23_RS25375	COG1201	RNA secondary structure unwinding
C3K23_RS25400	COG0628	permease
C3K23_RS25425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3K23_RS25430	COG2137	regulation of response to DNA damage stimulus
C3K23_RS25435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3K23_RS25445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3K23_RS25450	COG0765	amino acid transport
C3K23_RS25455	COG0765	amino acid transport
C3K23_RS25460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K23_RS25465	COG1126	abc transporter atp-binding protein
C3K23_RS25470	COG0745	RESPONSE REGULATOR receiver
C3K23_RS25475	COG2205	protein histidine kinase activity
C3K23_RS25485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3K23_RS25505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3K23_RS25515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3K23_RS25520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3K23_RS25530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3K23_RS25575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3K23_RS25580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3K23_RS25605	COG0588	phosphoglycerate mutase activity
C3K23_RS25620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3K23_RS25660	COG1802	Transcriptional regulator
C3K23_RS25665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3K23_RS25685	COG1309	transcriptional regulator
C3K23_RS25700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K23_RS25720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3K23_RS25725	COG0612	Peptidase, M16
C3K23_RS25740	COG1802	Transcriptional regulator
C3K23_RS25745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K23_RS25800	COG0483	inositol monophosphate 1-phosphatase activity
C3K23_RS25805	COG0745	RESPONSE REGULATOR receiver
C3K23_RS25810	COG2205	protein histidine kinase activity
C3K23_RS25835	COG0756	dUTP diphosphatase activity
C3K23_RS25855	COG1136	(ABC) transporter
C3K23_RS25885	COG0569	domain protein
C3K23_RS25890	COG0531	amino acid
C3K23_RS25895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3K23_RS25900	COG1201	RNA secondary structure unwinding
C3K23_RS25955	COG1063	alcohol dehydrogenase
C3K23_RS25960	COG0395	ABC-type sugar transport system, permease component
C3K23_RS26055	COG1127	ABC transporter
C3K23_RS26065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3K23_RS26090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C3K23_RS26125	COG0656	L-ascorbic acid biosynthetic process
C3K23_RS26140	COG0473	3-isopropylmalate dehydrogenase activity
C3K23_RS26150	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C3K23_RS26200	COG0252	asparaginase activity
C3K23_RS26205	COG0738	Major facilitator superfamily
C3K23_RS26210	COG3226	Transcriptional regulator
C3K23_RS26250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3K23_RS26270	COG0640	Transcriptional regulator
C3K23_RS26275	COG0789	Transcriptional regulator
C3K23_RS26290	COG2050	protein possibly involved in aromatic compounds catabolism
C3K23_RS26300	COG3540	Alkaline phosphatase
C3K23_RS26345	COG1733	regulation of RNA biosynthetic process
C3K23_RS26355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS26360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS26365	COG1120	ATPase activity
C3K23_RS26380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3K23_RS26425	COG1620	l-lactate permease
C3K23_RS26430	COG0247	lactate metabolic process
C3K23_RS26435	COG1139	Iron-sulfur cluster binding protein
C3K23_RS26440	COG1556	Lactate utilization protein
C3K23_RS26455	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C3K23_RS26465	COG1799	cell septum assembly
C3K23_RS26500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C3K23_RS26520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3K23_RS26525	COG0531	amino acid
C3K23_RS26555	COG2124	cytochrome p450
C3K23_RS26565	COG2111	Na H antiporter
C3K23_RS26565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3K23_RS26590	COG1320	monovalent cation:proton antiporter activity
C3K23_RS26630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3K23_RS26660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3K23_RS26665	COG1653	transport
C3K23_RS26670	COG1175	transmembrane transport
C3K23_RS26675	COG0395	ABC-type sugar transport system, permease component
C3K23_RS26685	COG4213	ABC transporter substrate-binding protein
C3K23_RS26695	COG4214	carbohydrate transport
C3K23_RS26700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3K23_RS26705	COG0531	amino acid
C3K23_RS26725	COG1024	Enoyl-CoA hydratase
C3K23_RS26725	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS26730	COG0183	Belongs to the thiolase family
C3K23_RS26750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3K23_RS26755	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3K23_RS26780	COG3220	belongs to the UPF0276 family
C3K23_RS26790	COG0726	polysaccharide deacetylase
C3K23_RS26805	COG1595	DNA-templated transcription, initiation
C3K23_RS26830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3K23_RS26835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3K23_RS26900	COG2176	DNA-directed DNA polymerase activity
C3K23_RS26900	COG5002	protein histidine kinase activity
C3K23_RS26935	COG0386	Belongs to the glutathione peroxidase family
C3K23_RS26950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3K23_RS26955	COG1116	anion transmembrane transporter activity
C3K23_RS26980	COG0529	Catalyzes the synthesis of activated sulfate
C3K23_RS26985	COG0175	sulfate reduction
C3K23_RS26995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3K23_RS27020	COG0604	alcohol dehydrogenase
C3K23_RS27025	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS27045	COG2040	homocysteine
C3K23_RS27070	COG2255	four-way junction helicase activity
C3K23_RS27080	COG1120	ATPase activity
C3K23_RS27085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS27095	COG2409	Drug exporters of the RND superfamily
C3K23_RS27100	COG1846	Transcriptional regulator
C3K23_RS27105	COG0702	epimerase
C3K23_RS27120	COG1595	DNA-templated transcription, initiation
C3K23_RS27155	COG2365	Tyrosine phosphatase family
C3K23_RS27165	COG1162	GTPase activity
C3K23_RS27170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3K23_RS27190	COG0028	Belongs to the TPP enzyme family
C3K23_RS27210	COG1802	Transcriptional regulator
C3K23_RS27225	COG3835	regulator
C3K23_RS27240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3K23_RS27245	COG2252	PERMEase
C3K23_RS27275	COG1073	alpha beta
C3K23_RS27305	COG2197	response regulator
C3K23_RS27310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3K23_RS27315	COG0318	PFAM AMP-dependent synthetase and ligase
C3K23_RS27325	COG3960	tartronate-semialdehyde synthase activity
C3K23_RS27335	COG0753	catalase activity
C3K23_RS27340	COG2084	Dehydrogenase
C3K23_RS27345	COG3622	Belongs to the hyi family
C3K23_RS27365	COG2351	hydroxyisourate hydrolase activity
C3K23_RS27380	COG2233	PERMEase
C3K23_RS27430	COG1609	Transcriptional regulator
C3K23_RS27445	COG1609	Transcriptional regulator
C3K23_RS27450	COG1621	beta-fructofuranosidase activity
C3K23_RS27455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3K23_RS27460	COG3795	YCII-related domain
C3K23_RS27465	COG4941	Belongs to the sigma-70 factor family
C3K23_RS27485	COG2080	2 iron, 2 sulfur cluster binding
C3K23_RS27490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3K23_RS27495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3K23_RS27510	COG1414	Transcriptional regulator
C3K23_RS27515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3K23_RS27530	COG4585	Histidine kinase
C3K23_RS27535	COG2197	response regulator
C3K23_RS27545	COG0673	inositol 2-dehydrogenase activity
C3K23_RS27550	COG2188	Transcriptional regulator
C3K23_RS27560	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3K23_RS27570	COG1940	carbohydrate kinase activity
C3K23_RS27580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3K23_RS27660	COG0464	growth
C3K23_RS27670	COG2197	response regulator
C3K23_RS27700	COG1132	(ABC) transporter
C3K23_RS27705	COG2133	pyrroloquinoline quinone binding
C3K23_RS27705	COG5183	chlorophyll binding
C3K23_RS27715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3K23_RS27745	COG1126	abc transporter atp-binding protein
C3K23_RS27750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K23_RS27755	COG0765	amino acid transport
C3K23_RS27760	COG0765	amino acid transport
C3K23_RS27785	COG0405	Gamma-glutamyltransferase
C3K23_RS27810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3K23_RS27830	COG0095	Lipoate-protein ligase
C3K23_RS27840	COG0483	inositol monophosphate 1-phosphatase activity
C3K23_RS27865	COG0159	tryptophan synthase activity
C3K23_RS27890	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C3K23_RS27895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C3K23_RS27905	COG0488	(ABC) transporter
C3K23_RS27910	COG1929	Belongs to the glycerate kinase type-1 family
C3K23_RS27925	COG0688	phosphatidylethanolamine metabolic process
C3K23_RS27940	COG2301	Belongs to the HpcH HpaI aldolase family
C3K23_RS27945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3K23_RS27945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3K23_RS27950	COG0604	alcohol dehydrogenase
C3K23_RS27960	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS27965	COG1120	ATPase activity
C3K23_RS27970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS27975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K23_RS28035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K23_RS28045	COG1619	proteins homologs of microcin C7 resistance protein MccF
C3K23_RS28060	COG1309	transcriptional regulator
C3K23_RS28075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K23_RS28095	COG3226	Transcriptional regulator
C3K23_RS28110	COG4106	trans-aconitate 2-methyltransferase activity
C3K23_RS28115	COG1597	lipid kinase activity
C3K23_RS28125	COG0693	protein deglycase activity
C3K23_RS28205	COG2154	pterin-4-alpha-carbinolamine dehydratase
C3K23_RS28220	COG0656	L-ascorbic acid biosynthetic process
C3K23_RS28230	COG1115	amino acid carrier protein
C3K23_RS28235	COG0583	DNA-binding transcription factor activity
C3K23_RS28245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3K23_RS28255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3K23_RS28260	COG1940	carbohydrate kinase activity
C3K23_RS28265	COG1129	ABC transporter
C3K23_RS28270	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3K23_RS28275	COG1879	ABC-type sugar transport system periplasmic component
C3K23_RS28280	COG0673	inositol 2-dehydrogenase activity
C3K23_RS28345	COG1295	ribonuclease BN
C3K23_RS28365	COG1609	Transcriptional regulator
C3K23_RS28370	COG1129	ABC transporter
C3K23_RS28375	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3K23_RS28380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K23_RS28385	COG1869	D-ribose catabolic process
C3K23_RS28395	COG2259	Doxx family
C3K23_RS28405	COG2274	protein secretion by the type I secretion system
C3K23_RS28410	COG2274	protein secretion by the type I secretion system
C3K23_RS28445	COG0789	Transcriptional regulator
C3K23_RS28480	COG1024	Enoyl-CoA hydratase
C3K23_RS28485	COG1793	dna ligase
C3K23_RS28495	COG0254	rRNA binding
C3K23_RS28525	COG0438	transferase activity, transferring glycosyl groups
C3K23_RS28540	COG2197	response regulator
C3K23_RS28560	COG0488	(ABC) transporter
C3K23_RS28570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3K23_RS28570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3K23_RS28580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K23_RS28600	COG1515	deoxyribonuclease V activity
C3K23_RS28610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3K23_RS28620	COG0183	Belongs to the thiolase family
C3K23_RS28625	COG1024	Enoyl-CoA hydratase
C3K23_RS28625	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS28630	COG0789	Transcriptional regulator
C3K23_RS28635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C3K23_RS28655	COG0402	S-adenosylhomocysteine deaminase activity
C3K23_RS28660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3K23_RS28665	COG1802	Transcriptional regulator
C3K23_RS28695	COG1024	Enoyl-CoA hydratase
C3K23_RS28710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C3K23_RS28725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3K23_RS28750	COG1388	LysM domain
C3K23_RS28750	COG1134	teichoic acid transport
C3K23_RS28755	COG1562	ergosterol biosynthetic process
C3K23_RS28765	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C3K23_RS28775	COG1657	PFAM Prenyltransferase squalene oxidase
C3K23_RS28810	COG2755	lipolytic protein G-D-S-L family
C3K23_RS28875	COG3958	Transketolase
C3K23_RS28880	COG3959	Transketolase, thiamine diphosphate binding domain
C3K23_RS28900	COG0640	Transcriptional regulator
C3K23_RS28905	COG0789	Transcriptional regulator
C3K23_RS28910	COG0659	secondary active sulfate transmembrane transporter activity
C3K23_RS28915	COG2072	flavoprotein involved in K transport
C3K23_RS28920	COG0798	PFAM Bile acid sodium symporter
C3K23_RS28930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3K23_RS28955	COG0740	serine-type endopeptidase activity
C3K23_RS28960	COG0740	serine-type endopeptidase activity
C3K23_RS29005	COG2391	methyltransferase activity
C3K23_RS29010	COG1960	acyl-CoA dehydrogenase activity
C3K23_RS29015	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS29020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3K23_RS29025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C3K23_RS29030	COG0583	DNA-binding transcription factor activity
C3K23_RS29040	COG0477	Major facilitator Superfamily
C3K23_RS29110	COG1233	COG1233 Phytoene dehydrogenase and related
C3K23_RS29115	COG2130	NADP-dependent
C3K23_RS29120	COG2124	cytochrome p450
C3K23_RS29155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3K23_RS29200	COG2018	Roadblock/LC7 domain
C3K23_RS29215	COG1946	Acyl-CoA thioesterase
C3K23_RS29230	COG1132	(ABC) transporter
C3K23_RS29235	COG1132	(ABC) transporter
C3K23_RS29260	COG1132	(ABC) transporter
C3K23_RS29265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3K23_RS29280	COG0432	Pfam Uncharacterised protein family UPF0047
C3K23_RS29335	COG1175	transmembrane transport
C3K23_RS29340	COG0395	ABC-type sugar transport system, permease component
C3K23_RS29345	COG1472	Belongs to the glycosyl hydrolase 3 family
C3K23_RS29390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3K23_RS29420	COG2706	6-phosphogluconolactonase activity
C3K23_RS29435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3K23_RS29465	COG1902	pentaerythritol trinitrate reductase activity
C3K23_RS29470	COG0640	Transcriptional regulator
C3K23_RS29580	COG2175	clavaminate synthase activity
C3K23_RS29585	COG3424	synthase
C3K23_RS29590	COG1024	Enoyl-CoA hydratase
C3K23_RS29595	COG1024	Enoyl-CoA hydratase
C3K23_RS29605	COG1834	amidinotransferase
C3K23_RS29625	COG0165	Argininosuccinate lyase
C3K23_RS29650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3K23_RS29675	COG1136	(ABC) transporter
C3K23_RS29675	COG0577	efflux transmembrane transporter activity
C3K23_RS29720	COG0671	phosphoesterase, PA-phosphatase related
C3K23_RS29740	COG1846	Transcriptional regulator
C3K23_RS29755	COG0584	glycerophosphoryl diester phosphodiesterase
C3K23_RS29800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3K23_RS29810	COG1609	Transcriptional regulator
C3K23_RS29835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K23_RS29845	COG2223	nitrite transmembrane transporter activity
C3K23_RS29855	COG1940	carbohydrate kinase activity
C3K23_RS29875	COG1349	DNA-binding transcription factor activity
C3K23_RS29910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3K23_RS29920	COG0513	Belongs to the DEAD box helicase family
C3K23_RS29935	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS29965	COG1695	Transcriptional regulator
C3K23_RS29975	COG0275	rRNA processing
C3K23_RS29995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3K23_RS30020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3K23_RS30025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K23_RS30025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3K23_RS30030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C3K23_RS30030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3K23_RS30030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3K23_RS30040	COG1349	DNA-binding transcription factor activity
C3K23_RS30060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K23_RS30065	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K23_RS30090	COG1120	ATPase activity
C3K23_RS30105	COG0640	Transcriptional regulator
C3K23_RS30110	COG0346	lactoylglutathione lyase activity
C3K23_RS30135	COG0326	Molecular chaperone. Has ATPase activity
C3K23_RS30155	COG1131	(ABC) transporter
C3K23_RS30160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3K23_RS30165	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS30180	COG0300	oxidoreductase activity
C3K23_RS30185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3K23_RS30220	COG1595	DNA-templated transcription, initiation
C3K23_RS30260	COG0328	RNA-DNA hybrid ribonuclease activity
C3K23_RS30275	COG0477	Major facilitator Superfamily
C3K23_RS30290	COG1309	transcriptional regulator
C3K23_RS30295	COG1131	(ABC) transporter
C3K23_RS30300	COG3559	Exporter of polyketide antibiotics
C3K23_RS30320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3K23_RS30330	COG2197	response regulator
C3K23_RS30350	COG0475	glutathione-regulated potassium exporter activity
C3K23_RS30380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3K23_RS30390	COG1902	pentaerythritol trinitrate reductase activity
C3K23_RS30390	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3K23_RS30400	COG5297	Belongs to the glycosyl hydrolase family 6
C3K23_RS30400	COG4733	cellulase activity
C3K23_RS30410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS30420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3K23_RS30430	COG0713	ATP synthesis coupled electron transport
C3K23_RS30435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3K23_RS30440	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3K23_RS30445	COG1007	ATP synthesis coupled electron transport
C3K23_RS30480	COG2084	Dehydrogenase
C3K23_RS30530	COG2356	endonuclease I
C3K23_RS30540	COG2813	Specifically methylates the guanine in position
C3K23_RS30545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3K23_RS30550	COG0589	response to stress
C3K23_RS30555	COG0318	PFAM AMP-dependent synthetase and ligase
C3K23_RS30600	COG0277	FAD linked oxidase domain protein
C3K23_RS30615	COG1793	dna ligase
C3K23_RS30650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3K23_RS30665	COG0601	transmembrane transport
C3K23_RS30670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K23_RS30675	COG0444	Belongs to the ABC transporter superfamily
C3K23_RS30680	COG4608	Belongs to the ABC transporter superfamily
C3K23_RS30725	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3K23_RS30725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3K23_RS30780	COG0477	Major facilitator Superfamily
C3K23_RS30790	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS30800	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C3K23_RS30805	COG4585	Histidine kinase
C3K23_RS30810	COG2197	response regulator
C3K23_RS30820	COG2080	2 iron, 2 sulfur cluster binding
C3K23_RS30825	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3K23_RS30830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3K23_RS30855	COG0477	Major facilitator Superfamily
C3K23_RS30860	COG1028	Short-chain dehydrogenase reductase Sdr
C3K23_RS30880	COG1175	transmembrane transport
C3K23_RS30885	COG0395	ABC-type sugar transport system, permease component
C3K23_RS30890	COG1609	Transcriptional regulator
C3K23_RS30895	COG1874	Beta-galactosidase
C3K23_RS30900	COG1472	Belongs to the glycosyl hydrolase 3 family