locus-tag	class	description
GZL_RS00015	COG1473	amidohydrolase
GZL_RS00025	COG3328	transposase activity
GZL_RS00095	COG1122	ATPase activity
GZL_RS00115	COG2814	Major facilitator Superfamily
GZL_RS00120	COG2267	carboxylic ester hydrolase activity
GZL_RS00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZL_RS00170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZL_RS00190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZL_RS00195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS00205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZL_RS00220	COG4555	ABC transporter
GZL_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS00310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS00345	COG3321	synthase
GZL_RS00345	COG0604	alcohol dehydrogenase
GZL_RS00345	COG3321	synthase
GZL_RS00345	COG0604	alcohol dehydrogenase
GZL_RS00350	COG3321	synthase
GZL_RS00350	COG0604	alcohol dehydrogenase
GZL_RS00355	COG3629	intracellular signal transduction
GZL_RS00360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZL_RS00380	COG0438	transferase activity, transferring glycosyl groups
GZL_RS00405	COG3321	synthase
GZL_RS00405	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS00405	COG0604	alcohol dehydrogenase
GZL_RS00485	COG2226	methyltransferase
GZL_RS00500	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZL_RS00545	COG1278	Cold shock
GZL_RS00630	COG3328	transposase activity
GZL_RS00690	COG0640	Transcriptional regulator
GZL_RS00695	COG2814	Major facilitator Superfamily
GZL_RS00785	COG0745	RESPONSE REGULATOR receiver
GZL_RS00840	COG3321	synthase
GZL_RS00840	COG0604	alcohol dehydrogenase
GZL_RS00905	COG2226	methyltransferase
GZL_RS00915	COG2770	Histidine kinase
GZL_RS00915	COG2208	phosphoserine phosphatase activity
GZL_RS00955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZL_RS00965	COG1309	transcriptional regulator
GZL_RS00970	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS00995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS01000	COG1309	transcriptional regulator
GZL_RS01065	COG2124	cytochrome p450
GZL_RS01085	COG2124	cytochrome p450
GZL_RS01090	COG3979	chitinase
GZL_RS01100	COG1335	isochorismatase
GZL_RS01115	COG2814	Major facilitator Superfamily
GZL_RS01125	COG4585	Histidine kinase
GZL_RS01140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZL_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS01200	COG0300	oxidoreductase activity
GZL_RS01220	COG3795	YCII-related domain
GZL_RS01230	COG2205	protein histidine kinase activity
GZL_RS01245	COG1683	Conserved Protein
GZL_RS01255	COG2197	response regulator
GZL_RS01270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS01310	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS01370	COG1309	transcriptional regulator
GZL_RS01390	COG1595	DNA-templated transcription, initiation
GZL_RS01420	COG0488	(ABC) transporter
GZL_RS01435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZL_RS01490	COG0516	GMP reductase activity
GZL_RS01490	COG0517	IMP dehydrogenase activity
GZL_RS01500	COG2326	polyphosphate kinase activity
GZL_RS01510	COG4249	Peptidase C14 caspase catalytic subunit p20
GZL_RS01510	COG2319	Wd-40 repeat
GZL_RS01535	COG2814	Major facilitator Superfamily
GZL_RS01560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZL_RS01570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GZL_RS01580	COG1309	transcriptional regulator
GZL_RS01610	COG1802	Transcriptional regulator
GZL_RS01615	COG0596	Alpha beta hydrolase
GZL_RS01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS01645	COG0702	epimerase
GZL_RS01655	COG1309	transcriptional regulator
GZL_RS01665	COG3963	phosphatidate phosphatase activity
GZL_RS01680	COG1121	(ABC) transporter
GZL_RS01685	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZL_RS01710	COG2197	response regulator
GZL_RS01715	COG4585	Histidine kinase
GZL_RS01725	COG1136	(ABC) transporter
GZL_RS01730	COG1078	dGTPase activity
GZL_RS01750	COG1309	transcriptional regulator
GZL_RS01755	COG1132	(ABC) transporter
GZL_RS01780	COG2957	Belongs to the agmatine deiminase family
GZL_RS01800	COG0831	urea catabolic process
GZL_RS01800	COG0832	Belongs to the urease beta subunit family
GZL_RS01805	COG0804	urea catabolic process
GZL_RS01810	COG2957	Belongs to the agmatine deiminase family
GZL_RS01815	COG0747	negative chemotaxis
GZL_RS01825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZL_RS01830	COG0444	Belongs to the ABC transporter superfamily
GZL_RS01850	COG1937	Protein conserved in bacteria
GZL_RS01855	COG0730	response to heat
GZL_RS01875	COG0483	inositol monophosphate 1-phosphatase activity
GZL_RS01910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZL_RS01920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZL_RS01930	COG3291	Pkd domain containing protein
GZL_RS01955	COG1216	Glycosyl transferase, family 2
GZL_RS01955	COG1442	glycosyl transferase family 8
GZL_RS01960	COG1316	TRANSCRIPTIONal
GZL_RS01965	COG1473	amidohydrolase
GZL_RS01975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GZL_RS01980	COG1846	Transcriptional regulator
GZL_RS01985	COG1902	pentaerythritol trinitrate reductase activity
GZL_RS02005	COG2267	carboxylic ester hydrolase activity
GZL_RS02020	COG0596	Alpha beta hydrolase
GZL_RS02035	COG4221	oxidoreductase activity
GZL_RS02045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZL_RS02050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZL_RS02080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS02145	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZL_RS02150	COG0640	Transcriptional regulator
GZL_RS02155	COG0038	chloride channel
GZL_RS02160	COG1618	nucleotide phosphatase activity, acting on free nucleotides
GZL_RS02165	COG2409	Drug exporters of the RND superfamily
GZL_RS02170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZL_RS02175	COG0156	8-amino-7-oxononanoate synthase activity
GZL_RS02205	COG1309	transcriptional regulator
GZL_RS02255	COG0492	ferredoxin-NADP+ reductase activity
GZL_RS02275	COG4221	oxidoreductase activity
GZL_RS02295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS02305	COG0667	Aldo Keto reductase
GZL_RS02340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GZL_RS02345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZL_RS02360	COG1333	cytochrome c biogenesis protein
GZL_RS02365	COG2814	Major facilitator Superfamily
GZL_RS02385	COG0688	phosphatidylethanolamine metabolic process
GZL_RS02415	COG0589	response to stress
GZL_RS02425	COG4585	Histidine kinase
GZL_RS02470	COG2070	2-Nitropropane dioxygenase
GZL_RS02480	COG1131	(ABC) transporter
GZL_RS02495	COG0142	geranyltranstransferase activity
GZL_RS02525	COG1733	regulation of RNA biosynthetic process
GZL_RS02530	COG0243	molybdopterin cofactor binding
GZL_RS02545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZL_RS02550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZL_RS02570	COG0515	serine threonine protein kinase
GZL_RS02570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZL_RS02585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZL_RS02605	COG3961	Belongs to the TPP enzyme family
GZL_RS02610	COG1846	Transcriptional regulator
GZL_RS02625	COG0477	Major facilitator Superfamily
GZL_RS02635	COG0477	Major facilitator Superfamily
GZL_RS02655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZL_RS02660	COG2226	methyltransferase
GZL_RS02665	COG2205	protein histidine kinase activity
GZL_RS02670	COG0745	RESPONSE REGULATOR receiver
GZL_RS02675	COG0577	efflux transmembrane transporter activity
GZL_RS02680	COG1136	(ABC) transporter
GZL_RS02690	COG0539	negative regulation of cytoplasmic translation
GZL_RS02710	COG0587	DNA-directed DNA polymerase activity
GZL_RS02740	COG4941	Belongs to the sigma-70 factor family
GZL_RS02770	COG0477	Major facilitator Superfamily
GZL_RS02800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GZL_RS02810	COG0577	efflux transmembrane transporter activity
GZL_RS02810	COG1136	(ABC) transporter
GZL_RS02815	COG0577	efflux transmembrane transporter activity
GZL_RS02815	COG1136	(ABC) transporter
GZL_RS02820	COG2197	response regulator
GZL_RS02825	COG4585	Histidine kinase
GZL_RS02830	COG2755	lipolytic protein G-D-S-L family
GZL_RS02845	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS02855	COG0393	Putative heavy-metal-binding
GZL_RS02945	COG1231	oxidoreductase activity
GZL_RS02995	COG0583	DNA-binding transcription factor activity
GZL_RS03065	COG1595	DNA-templated transcription, initiation
GZL_RS03085	COG2226	methyltransferase
GZL_RS03090	COG0488	(ABC) transporter
GZL_RS03100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZL_RS03110	COG2130	NADP-dependent
GZL_RS03195	COG0586	Pfam SNARE associated Golgi protein
GZL_RS03205	COG3851	Histidine kinase
GZL_RS03210	COG2197	response regulator
GZL_RS03220	COG4221	oxidoreductase activity
GZL_RS03260	COG0242	peptide deformylase activity
GZL_RS03265	COG0702	epimerase
GZL_RS03275	COG1473	amidohydrolase
GZL_RS03300	COG2197	response regulator
GZL_RS03315	COG3321	synthase
GZL_RS03315	COG0604	alcohol dehydrogenase
GZL_RS03325	COG3321	synthase
GZL_RS03325	COG0604	alcohol dehydrogenase
GZL_RS03335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZL_RS03400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZL_RS03420	COG3118	belongs to the thioredoxin family
GZL_RS03440	COG0504	CTP synthase activity
GZL_RS03455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZL_RS03490	COG2011	ABC-type metal ion transport system permease component
GZL_RS03500	COG1464	Belongs to the NlpA lipoprotein family
GZL_RS03530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZL_RS03565	COG3757	hydrolase, family 25
GZL_RS03565	COG3409	Peptidoglycan-binding domain 1 protein
GZL_RS03580	COG2084	Dehydrogenase
GZL_RS03585	COG1309	transcriptional regulator
GZL_RS03665	COG2205	protein histidine kinase activity
GZL_RS03775	COG0395	ABC-type sugar transport system, permease component
GZL_RS03780	COG1175	transmembrane transport
GZL_RS03805	COG2226	methyltransferase
GZL_RS03825	COG2132	Multicopper oxidase
GZL_RS03830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS03835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GZL_RS03855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GZL_RS03880	COG1191	sigma factor activity
GZL_RS03890	COG3631	Ketosteroid isomerase-related protein
GZL_RS03895	COG0702	epimerase
GZL_RS03900	COG2124	cytochrome p450
GZL_RS03905	COG2378	regulation of single-species biofilm formation
GZL_RS03925	COG0009	L-threonylcarbamoyladenylate synthase
GZL_RS03930	COG3469	chitinase activity
GZL_RS03935	COG2423	ornithine cyclodeaminase activity
GZL_RS03945	COG0367	asparagine synthase
GZL_RS03960	COG2226	methyltransferase
GZL_RS03965	COG0488	(ABC) transporter
GZL_RS03970	COG1216	Glycosyl transferase, family 2
GZL_RS03975	COG0301	tRNA thio-modification
GZL_RS03980	COG0640	Transcriptional regulator
GZL_RS04010	COG2239	Acts as a magnesium transporter
GZL_RS04025	COG2205	protein histidine kinase activity
GZL_RS04030	COG0745	RESPONSE REGULATOR receiver
GZL_RS04035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZL_RS04035	COG1017	nitric oxide dioxygenase activity
GZL_RS04065	COG0443	Heat shock 70 kDa protein
GZL_RS04070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GZL_RS04080	COG4585	Histidine kinase
GZL_RS04085	COG2197	response regulator
GZL_RS04110	COG0596	Alpha beta hydrolase
GZL_RS04160	COG1335	isochorismatase
GZL_RS04190	COG1169	isochorismate synthase
GZL_RS04215	COG2197	response regulator
GZL_RS04245	COG2267	carboxylic ester hydrolase activity
GZL_RS04260	COG1131	(ABC) transporter
GZL_RS04280	COG2197	response regulator
GZL_RS04285	COG4585	Histidine kinase
GZL_RS04305	COG2226	methyltransferase
GZL_RS04325	COG2197	response regulator
GZL_RS04330	COG4585	Histidine kinase
GZL_RS04345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GZL_RS04345	COG3291	Pkd domain containing protein
GZL_RS04350	COG0577	efflux transmembrane transporter activity
GZL_RS04485	COG4279	zinc finger
GZL_RS04490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZL_RS04580	COG0583	DNA-binding transcription factor activity
GZL_RS04635	COG0667	Aldo Keto reductase
GZL_RS04645	COG0583	DNA-binding transcription factor activity
GZL_RS04650	COG0789	Transcriptional regulator
GZL_RS04705	COG1116	anion transmembrane transporter activity
GZL_RS04720	COG0531	amino acid
GZL_RS04745	COG4977	sequence-specific DNA binding
GZL_RS04770	COG1902	pentaerythritol trinitrate reductase activity
GZL_RS04775	COG0477	Major facilitator Superfamily
GZL_RS04785	COG0583	DNA-binding transcription factor activity
GZL_RS04810	COG3848	Pyruvate phosphate dikinase
GZL_RS04810	COG0574	Belongs to the PEP-utilizing enzyme family
GZL_RS04865	COG1585	Membrane protein implicated in regulation of membrane protease activity
GZL_RS04870	COG2268	Band 7 protein
GZL_RS04880	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
GZL_RS04900	COG2837	iron assimilation
GZL_RS04920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZL_RS04925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZL_RS04965	COG0640	Transcriptional regulator
GZL_RS04980	COG1316	TRANSCRIPTIONal
GZL_RS04985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZL_RS05005	COG2261	transglycosylase associated protein
GZL_RS05065	COG3511	phospholipase C
GZL_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS05105	COG1024	Enoyl-CoA hydratase
GZL_RS05125	COG2365	Tyrosine phosphatase family
GZL_RS05150	COG0477	Major facilitator Superfamily
GZL_RS05155	COG0583	DNA-binding transcription factor activity
GZL_RS05180	COG0183	Belongs to the thiolase family
GZL_RS05185	COG1309	transcriptional regulator
GZL_RS05195	COG1960	acyl-CoA dehydrogenase activity
GZL_RS05200	COG1024	Enoyl-CoA hydratase
GZL_RS05205	COG1960	acyl-CoA dehydrogenase activity
GZL_RS05210	COG1960	acyl-CoA dehydrogenase activity
GZL_RS05215	COG1960	acyl-CoA dehydrogenase activity
GZL_RS05225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZL_RS05235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS05240	COG3547	Transposase (IS116 IS110 IS902 family)
GZL_RS05250	COG0657	acetylesterase activity
GZL_RS05325	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS05340	COG1793	dna ligase
GZL_RS05355	COG0531	amino acid
GZL_RS05360	COG0640	Transcriptional regulator
GZL_RS05380	COG2837	iron assimilation
GZL_RS05400	COG0309	Hydrogenase expression formation protein (HypE)
GZL_RS05410	COG0298	carbon dioxide binding
GZL_RS05420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GZL_RS05425	COG0375	protein maturation
GZL_RS05455	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GZL_RS05470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZL_RS05475	COG2186	Transcriptional regulator
GZL_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS05500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GZL_RS05515	COG2124	cytochrome p450
GZL_RS05520	COG2084	Dehydrogenase
GZL_RS05525	COG3622	Belongs to the hyi family
GZL_RS05530	COG3960	tartronate-semialdehyde synthase activity
GZL_RS05535	COG2205	protein histidine kinase activity
GZL_RS05550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZL_RS05570	COG2814	Major facilitator Superfamily
GZL_RS05610	COG1960	acyl-CoA dehydrogenase activity
GZL_RS05620	COG0242	peptide deformylase activity
GZL_RS05630	COG3442	glutamine amidotransferase
GZL_RS05635	COG0205	6-phosphofructokinase activity
GZL_RS05640	COG3336	cytochrome c oxidase
GZL_RS05660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZL_RS05690	COG0829	nickel cation binding
GZL_RS05695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GZL_RS05705	COG0804	urea catabolic process
GZL_RS05710	COG0832	Belongs to the urease beta subunit family
GZL_RS05715	COG0831	urea catabolic process
GZL_RS05730	COG0740	serine-type endopeptidase activity
GZL_RS05740	COG0791	NLP P60 protein
GZL_RS05755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GZL_RS05760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZL_RS05765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GZL_RS05795	COG0456	acetyltransferase
GZL_RS05855	COG1435	thymidine kinase activity
GZL_RS05865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZL_RS05935	COG3617	BRO family, N-terminal domain
GZL_RS06155	COG0456	acetyltransferase
GZL_RS06200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZL_RS06220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZL_RS06235	COG1940	carbohydrate kinase activity
GZL_RS06240	COG2188	Transcriptional regulator
GZL_RS06245	COG1595	DNA-templated transcription, initiation
GZL_RS06270	COG1522	sequence-specific DNA binding
GZL_RS06275	COG0419	ATPase involved in DNA repair
GZL_RS06280	COG0420	3'-5' exonuclease activity
GZL_RS06310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZL_RS06320	COG0531	amino acid
GZL_RS06325	COG1739	Uncharacterized protein family UPF0029
GZL_RS06335	COG1832	CoA-binding protein
GZL_RS06355	COG0110	maltose O-acetyltransferase activity
GZL_RS06365	COG1024	Enoyl-CoA hydratase
GZL_RS06440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZL_RS06500	COG1764	response to oxidative stress
GZL_RS06505	COG1846	Transcriptional regulator
GZL_RS06515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZL_RS06545	COG0739	heme binding
GZL_RS06550	COG2197	response regulator
GZL_RS06555	COG4585	Histidine kinase
GZL_RS06570	COG1609	Transcriptional regulator
GZL_RS06580	COG1175	transmembrane transport
GZL_RS06585	COG0395	ABC-type sugar transport system, permease component
GZL_RS06620	COG1278	Cold shock
GZL_RS06630	COG2814	Major facilitator Superfamily
GZL_RS06635	COG3285	dna ligase
GZL_RS06635	COG1793	dna ligase
GZL_RS06640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GZL_RS06650	COG3012	SEC-C Motif Domain Protein
GZL_RS06690	COG0463	Glycosyl transferase, family 2
GZL_RS06700	COG1228	amidohydrolase
GZL_RS06725	COG1960	acyl-CoA dehydrogenase activity
GZL_RS06735	COG1309	transcriptional regulator
GZL_RS06755	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS06790	COG2963	transposase activity
GZL_RS06795	COG2801	Transposase and inactivated derivatives
GZL_RS06805	COG0596	Alpha beta hydrolase
GZL_RS06835	COG1902	pentaerythritol trinitrate reductase activity
GZL_RS06850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZL_RS06865	COG0300	oxidoreductase activity
GZL_RS06875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZL_RS06890	COG0657	acetylesterase activity
GZL_RS06900	COG2837	iron assimilation
GZL_RS06910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GZL_RS06915	COG0583	DNA-binding transcription factor activity
GZL_RS06920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZL_RS06920	COG1796	DNA polymerase
GZL_RS06940	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GZL_RS06960	COG1609	Transcriptional regulator
GZL_RS06965	COG1957	nucleoside hydrolase
GZL_RS06970	COG0477	Major facilitator Superfamily
GZL_RS06985	COG2890	protein-(glutamine-N5) methyltransferase activity
GZL_RS07010	COG1285	pathogenesis
GZL_RS07080	COG1733	regulation of RNA biosynthetic process
GZL_RS07125	COG0583	DNA-binding transcription factor activity
GZL_RS07165	COG1522	sequence-specific DNA binding
GZL_RS07190	COG0697	spore germination
GZL_RS07195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZL_RS07225	COG0583	DNA-binding transcription factor activity
GZL_RS07245	COG0110	maltose O-acetyltransferase activity
GZL_RS07250	COG4257	antibiotic catabolic process
GZL_RS07260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS07275	COG2815	serine threonine protein kinase
GZL_RS07275	COG0515	serine threonine protein kinase
GZL_RS07330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZL_RS07340	COG1309	transcriptional regulator
GZL_RS07360	COG0740	serine-type endopeptidase activity
GZL_RS07365	COG0740	serine-type endopeptidase activity
GZL_RS07370	COG2124	cytochrome p450
GZL_RS07380	COG1902	pentaerythritol trinitrate reductase activity
GZL_RS07390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZL_RS07400	COG2971	BadF BadG BcrA BcrD
GZL_RS07415	COG2706	6-phosphogluconolactonase activity
GZL_RS07420	COG0829	nickel cation binding
GZL_RS07425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GZL_RS07435	COG0804	urea catabolic process
GZL_RS07440	COG0831	urea catabolic process
GZL_RS07440	COG0832	Belongs to the urease beta subunit family
GZL_RS07465	COG4213	ABC transporter substrate-binding protein
GZL_RS07480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZL_RS07485	COG0019	diaminopimelate decarboxylase activity
GZL_RS07500	COG4166	transmembrane transport
GZL_RS07505	COG0601	transmembrane transport
GZL_RS07510	COG3547	Transposase (IS116 IS110 IS902 family)
GZL_RS07515	COG4171	peptide transport system, permease
GZL_RS07555	COG1309	transcriptional regulator
GZL_RS07570	COG0789	Transcriptional regulator
GZL_RS07585	COG1309	transcriptional regulator
GZL_RS07610	COG3467	pyridoxamine 5'-phosphate
GZL_RS07625	COG2304	oxidoreductase activity
GZL_RS07635	COG0477	Major facilitator Superfamily
GZL_RS07640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS07690	COG0583	DNA-binding transcription factor activity
GZL_RS07695	COG4608	Belongs to the ABC transporter superfamily
GZL_RS07705	COG0601	transmembrane transport
GZL_RS07710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZL_RS07720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZL_RS07740	COG3938	Belongs to the proline racemase family
GZL_RS07755	COG1802	Transcriptional regulator
GZL_RS07830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZL_RS07835	COG1116	anion transmembrane transporter activity
GZL_RS07855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZL_RS07865	COG0477	Major facilitator Superfamily
GZL_RS07870	COG0247	lactate metabolic process
GZL_RS07875	COG1139	Iron-sulfur cluster binding protein
GZL_RS07880	COG1556	Lactate utilization protein
GZL_RS07890	COG1132	(ABC) transporter
GZL_RS07925	COG1132	(ABC) transporter
GZL_RS07930	COG1132	(ABC) transporter
GZL_RS07945	COG1946	Acyl-CoA thioesterase
GZL_RS07960	COG2018	Roadblock/LC7 domain
GZL_RS08005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZL_RS08020	COG2040	homocysteine
GZL_RS08030	COG0765	amino acid transport
GZL_RS08035	COG1126	abc transporter atp-binding protein
GZL_RS08045	COG3458	cephalosporin-C deacetylase activity
GZL_RS08050	COG1070	Carbohydrate kinase
GZL_RS08055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZL_RS08060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZL_RS08085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GZL_RS08085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GZL_RS08090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZL_RS08095	COG0588	phosphoglycerate mutase activity
GZL_RS08100	COG1070	Carbohydrate kinase
GZL_RS08110	COG2814	Major facilitator Superfamily
GZL_RS08130	COG0444	Belongs to the ABC transporter superfamily
GZL_RS08135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZL_RS08140	COG0601	transmembrane transport
GZL_RS08180	COG0202	RNA polymerase activity
GZL_RS08215	COG1960	acyl-CoA dehydrogenase activity
GZL_RS08220	COG1960	acyl-CoA dehydrogenase activity
GZL_RS08250	COG3572	ergothioneine biosynthetic process
GZL_RS08255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GZL_RS08265	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GZL_RS08290	COG2124	cytochrome p450
GZL_RS08290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GZL_RS08305	COG3360	Dodecin
GZL_RS08310	COG0531	amino acid
GZL_RS08330	COG3537	Alpha-1,2-mannosidase
GZL_RS08390	COG0596	Alpha beta hydrolase
GZL_RS08430	COG2706	6-phosphogluconolactonase activity
GZL_RS08435	COG1113	amino acid transport
GZL_RS08440	COG1652	LysM domain
GZL_RS08450	COG1960	acyl-CoA dehydrogenase activity
GZL_RS08455	COG1024	Enoyl-CoA hydratase
GZL_RS08490	COG0477	Major facilitator Superfamily
GZL_RS08500	COG0174	glutamine synthetase
GZL_RS08520	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS08545	COG1686	Belongs to the peptidase S11 family
GZL_RS08550	COG2124	cytochrome p450
GZL_RS08585	COG3959	Transketolase, thiamine diphosphate binding domain
GZL_RS08590	COG3958	Transketolase
GZL_RS08595	COG2267	carboxylic ester hydrolase activity
GZL_RS08600	COG0402	S-adenosylhomocysteine deaminase activity
GZL_RS08625	COG2018	Roadblock/LC7 domain
GZL_RS08645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZL_RS08670	COG2755	lipolytic protein G-D-S-L family
GZL_RS08675	COG2365	Tyrosine phosphatase family
GZL_RS08695	COG1657	PFAM Prenyltransferase squalene oxidase
GZL_RS08705	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GZL_RS08715	COG1562	ergosterol biosynthetic process
GZL_RS08720	COG1134	teichoic acid transport
GZL_RS08755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GZL_RS08790	COG4977	sequence-specific DNA binding
GZL_RS08800	COG2183	response to ionizing radiation
GZL_RS08825	COG2936	dipeptidyl-peptidase activity
GZL_RS08860	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS08870	COG3568	Endonuclease Exonuclease Phosphatase
GZL_RS08880	COG1113	amino acid transport
GZL_RS08890	COG0789	Transcriptional regulator
GZL_RS08895	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS08895	COG1024	Enoyl-CoA hydratase
GZL_RS08900	COG0183	Belongs to the thiolase family
GZL_RS08905	COG1960	acyl-CoA dehydrogenase activity
GZL_RS08910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZL_RS08915	COG1285	pathogenesis
GZL_RS08925	COG3268	Saccharopine dehydrogenase
GZL_RS08930	COG1515	deoxyribonuclease V activity
GZL_RS08940	COG2814	Major facilitator Superfamily
GZL_RS08945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZL_RS08955	COG1349	DNA-binding transcription factor activity
GZL_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS08965	COG1309	transcriptional regulator
GZL_RS08975	COG1309	transcriptional regulator
GZL_RS08985	COG1846	Transcriptional regulator
GZL_RS08995	COG3226	Transcriptional regulator
GZL_RS09005	COG3547	Transposase (IS116 IS110 IS902 family)
GZL_RS09025	COG0745	RESPONSE REGULATOR receiver
GZL_RS09030	COG2205	protein histidine kinase activity
GZL_RS09080	COG0583	DNA-binding transcription factor activity
GZL_RS09105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZL_RS09120	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS09135	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GZL_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS09190	COG0667	Aldo Keto reductase
GZL_RS09195	COG0789	Transcriptional regulator
GZL_RS09265	COG2208	phosphoserine phosphatase activity
GZL_RS09265	COG2770	Histidine kinase
GZL_RS09275	COG0137	argininosuccinate synthase activity
GZL_RS09280	COG1113	amino acid transport
GZL_RS09285	COG0477	Major facilitator Superfamily
GZL_RS09290	COG2226	methyltransferase
GZL_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS09315	COG2197	response regulator
GZL_RS09330	COG0583	DNA-binding transcription factor activity
GZL_RS09365	COG2814	Major facilitator Superfamily
GZL_RS09380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZL_RS09395	COG0431	NADPH-dependent FMN reductase
GZL_RS09460	COG0640	Transcriptional regulator
GZL_RS09485	COG1280	lysine exporter protein (LysE YggA)
GZL_RS09495	COG0513	Belongs to the DEAD box helicase family
GZL_RS09500	COG1278	Cold shock
GZL_RS09515	COG1733	regulation of RNA biosynthetic process
GZL_RS09590	COG1335	isochorismatase
GZL_RS09615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZL_RS09620	COG0583	DNA-binding transcription factor activity
GZL_RS09630	COG2815	serine threonine protein kinase
GZL_RS09630	COG0515	serine threonine protein kinase
GZL_RS09660	COG1011	Hydrolase
GZL_RS09710	COG0789	Transcriptional regulator
GZL_RS09740	COG2197	response regulator
GZL_RS09750	COG0510	thiamine kinase activity
GZL_RS09755	COG1285	pathogenesis
GZL_RS09770	COG2826	transposase and inactivated derivatives, IS30 family
GZL_RS09800	COG1309	transcriptional regulator
GZL_RS09805	COG2197	response regulator
GZL_RS09810	COG0076	glutamate decarboxylase activity
GZL_RS09830	COG1113	amino acid transport
GZL_RS09845	COG0745	RESPONSE REGULATOR receiver
GZL_RS09850	COG2205	protein histidine kinase activity
GZL_RS09860	COG2755	lipolytic protein G-D-S-L family
GZL_RS09860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GZL_RS09920	COG0667	Aldo Keto reductase
GZL_RS09940	COG1063	alcohol dehydrogenase
GZL_RS09950	COG0667	Aldo Keto reductase
GZL_RS10000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZL_RS10020	COG0287	Prephenate dehydrogenase
GZL_RS10020	COG1605	Chorismate mutase
GZL_RS10030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GZL_RS10055	COG0583	DNA-binding transcription factor activity
GZL_RS10065	COG0656	L-ascorbic acid biosynthetic process
GZL_RS10075	COG4106	trans-aconitate 2-methyltransferase activity
GZL_RS10090	COG2154	pterin-4-alpha-carbinolamine dehydratase
GZL_RS10105	COG0531	amino acid
GZL_RS10140	COG1597	lipid kinase activity
GZL_RS10185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZL_RS10200	COG2124	cytochrome p450
GZL_RS10215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZL_RS10220	COG2362	D-Aminopeptidase
GZL_RS10230	COG0366	Alpha amylase catalytic
GZL_RS10245	COG4106	trans-aconitate 2-methyltransferase activity
GZL_RS10250	COG2208	phosphoserine phosphatase activity
GZL_RS10250	COG2172	sigma factor antagonist activity
GZL_RS10250	COG1366	Belongs to the anti-sigma-factor antagonist family
GZL_RS10275	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS10295	COG0604	alcohol dehydrogenase
GZL_RS10300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZL_RS10300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZL_RS10305	COG2301	Belongs to the HpcH HpaI aldolase family
GZL_RS10315	COG1960	acyl-CoA dehydrogenase activity
GZL_RS10320	COG0688	phosphatidylethanolamine metabolic process
GZL_RS10330	COG1929	Belongs to the glycerate kinase type-1 family
GZL_RS10335	COG0494	nUDIX hydrolase
GZL_RS10345	COG0667	Aldo Keto reductase
GZL_RS10420	COG1674	ftsk spoiiie
GZL_RS10465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZL_RS10470	COG0667	Aldo Keto reductase
GZL_RS10475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZL_RS10485	COG2815	serine threonine protein kinase
GZL_RS10485	COG0515	serine threonine protein kinase
GZL_RS10540	COG3387	PFAM Glycoside hydrolase 15-related
GZL_RS10550	COG0531	amino acid
GZL_RS10650	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GZL_RS10740	COG0438	transferase activity, transferring glycosyl groups
GZL_RS10780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GZL_RS10855	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZL_RS11215	COG1203	CRISPR-associated helicase, Cas3
GZL_RS11270	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GZL_RS11280	COG0483	inositol monophosphate 1-phosphatase activity
GZL_RS11290	COG4221	oxidoreductase activity
GZL_RS11300	COG0095	Lipoate-protein ligase
GZL_RS11305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS11310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZL_RS11325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GZL_RS11340	COG0477	Major facilitator Superfamily
GZL_RS11345	COG1335	isochorismatase
GZL_RS11355	COG0405	Gamma-glutamyltransferase
GZL_RS11365	COG0387	Pfam Sodium calcium exchanger
GZL_RS11370	COG2409	Drug exporters of the RND superfamily
GZL_RS11375	COG3285	dna ligase
GZL_RS11375	COG1793	dna ligase
GZL_RS11380	COG0435	Glutathione S-transferase
GZL_RS11385	COG3708	Transcriptional regulator
GZL_RS11385	COG2207	Transcriptional regulator
GZL_RS11390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZL_RS11415	COG0765	amino acid transport
GZL_RS11420	COG0765	amino acid transport
GZL_RS11425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZL_RS11440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZL_RS11445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZL_RS11455	COG1940	carbohydrate kinase activity
GZL_RS11465	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZL_RS11475	COG2188	Transcriptional regulator
GZL_RS11490	COG0800	Aldolase
GZL_RS11520	COG4266	Belongs to the allantoicase family
GZL_RS11525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZL_RS11530	COG1953	Uracil, thiamine, allantoin
GZL_RS11540	COG1414	Transcriptional regulator
GZL_RS11560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GZL_RS11575	COG1288	antiporter activity
GZL_RS11595	COG2233	PERMEase
GZL_RS11605	COG2233	PERMEase
GZL_RS11615	COG2351	hydroxyisourate hydrolase activity
GZL_RS11635	COG3622	Belongs to the hyi family
GZL_RS11640	COG2084	Dehydrogenase
GZL_RS11645	COG0028	Belongs to the TPP enzyme family
GZL_RS11650	COG0753	catalase activity
GZL_RS11665	COG2315	Protein conserved in bacteria
GZL_RS11675	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS11690	COG0667	Aldo Keto reductase
GZL_RS11705	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS11750	COG1733	regulation of RNA biosynthetic process
GZL_RS11770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GZL_RS11785	COG3835	regulator
GZL_RS11800	COG1802	Transcriptional regulator
GZL_RS11825	COG0028	Belongs to the TPP enzyme family
GZL_RS11840	COG1162	GTPase activity
GZL_RS11850	COG0745	RESPONSE REGULATOR receiver
GZL_RS11855	COG0640	Transcriptional regulator
GZL_RS11870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZL_RS11875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZL_RS11875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZL_RS11925	COG2233	PERMEase
GZL_RS11930	COG1716	ATPase activity
GZL_RS11930	COG1131	(ABC) transporter
GZL_RS11930	COG0842	Transport permease protein
GZL_RS11955	COG1376	ErfK ybiS ycfS ynhG family protein
GZL_RS11960	COG3511	phospholipase C
GZL_RS11970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GZL_RS11975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GZL_RS11980	COG2080	2 iron, 2 sulfur cluster binding
GZL_RS12030	COG3485	protocatechuate 3,4-dioxygenase
GZL_RS12035	COG3485	protocatechuate 3,4-dioxygenase
GZL_RS12040	COG1414	Transcriptional regulator
GZL_RS12050	COG1960	acyl-CoA dehydrogenase activity
GZL_RS12075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZL_RS12080	COG0175	sulfate reduction
GZL_RS12085	COG0529	Catalyzes the synthesis of activated sulfate
GZL_RS12105	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GZL_RS12110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZL_RS12165	COG0583	DNA-binding transcription factor activity
GZL_RS12170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZL_RS12185	COG0693	protein deglycase activity
GZL_RS12190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZL_RS12200	COG0596	Alpha beta hydrolase
GZL_RS12215	COG1231	oxidoreductase activity
GZL_RS12230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GZL_RS12270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZL_RS12275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZL_RS12280	COG2197	response regulator
GZL_RS12295	COG0577	efflux transmembrane transporter activity
GZL_RS12295	COG1136	(ABC) transporter
GZL_RS12330	COG1116	anion transmembrane transporter activity
GZL_RS12345	COG1280	lysine exporter protein (LysE YggA)
GZL_RS12350	COG3220	belongs to the UPF0276 family
GZL_RS12355	COG3220	belongs to the UPF0276 family
GZL_RS12375	COG3253	May function as heme-dependent peroxidase
GZL_RS12380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GZL_RS12390	COG0183	Belongs to the thiolase family
GZL_RS12400	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZL_RS12405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GZL_RS12420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GZL_RS12425	COG0183	Belongs to the thiolase family
GZL_RS12430	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS12430	COG1024	Enoyl-CoA hydratase
GZL_RS12440	COG0531	amino acid
GZL_RS12445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZL_RS12450	COG4214	carbohydrate transport
GZL_RS12460	COG4213	ABC transporter substrate-binding protein
GZL_RS12465	COG1940	carbohydrate kinase activity
GZL_RS12470	COG0395	ABC-type sugar transport system, permease component
GZL_RS12475	COG1175	transmembrane transport
GZL_RS12480	COG1653	transport
GZL_RS12495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GZL_RS12520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZL_RS12525	COG1960	acyl-CoA dehydrogenase activity
GZL_RS12540	COG0546	phosphoglycolate phosphatase activity
GZL_RS12560	COG1024	Enoyl-CoA hydratase
GZL_RS12570	COG0531	amino acid
GZL_RS12575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GZL_RS12580	COG2235	arginine
GZL_RS12590	COG4977	sequence-specific DNA binding
GZL_RS12595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZL_RS12625	COG1799	cell septum assembly
GZL_RS12645	COG1309	transcriptional regulator
GZL_RS12670	COG3424	synthase
GZL_RS12695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZL_RS12700	COG0531	amino acid
GZL_RS12710	COG0569	domain protein
GZL_RS12745	COG1136	(ABC) transporter
GZL_RS12750	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GZL_RS12755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GZL_RS12760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GZL_RS12775	COG0756	dUTP diphosphatase activity
GZL_RS12800	COG2205	protein histidine kinase activity
GZL_RS12805	COG0745	RESPONSE REGULATOR receiver
GZL_RS12810	COG0483	inositol monophosphate 1-phosphatase activity
GZL_RS12815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZL_RS12850	COG1435	thymidine kinase activity
GZL_RS12870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZL_RS12875	COG1802	Transcriptional regulator
GZL_RS12890	COG0612	Peptidase, M16
GZL_RS12895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZL_RS12910	COG2197	response regulator
GZL_RS12915	COG4585	Histidine kinase
GZL_RS12925	COG0187	DNA topoisomerase II activity
GZL_RS12940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZL_RS12945	COG2186	Transcriptional regulator
GZL_RS12970	COG0066	3-isopropylmalate dehydratase activity
GZL_RS12975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GZL_RS12990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GZL_RS13000	COG0512	Glutamine amidotransferase of anthranilate synthase
GZL_RS13005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZL_RS13010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZL_RS13015	COG0134	indole-3-glycerol-phosphate synthase activity
GZL_RS13020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZL_RS13025	COG1834	amidinotransferase
GZL_RS13035	COG0475	glutathione-regulated potassium exporter activity
GZL_RS13050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZL_RS13095	COG0577	efflux transmembrane transporter activity
GZL_RS13095	COG1136	(ABC) transporter
GZL_RS13105	COG2197	response regulator
GZL_RS13135	COG0514	ATP-dependent DNA helicase (RecQ)
GZL_RS13150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZL_RS13160	COG0588	phosphoglycerate mutase activity
GZL_RS13165	COG0488	(ABC) transporter
GZL_RS13190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZL_RS13195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GZL_RS13200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZL_RS13235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZL_RS13265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GZL_RS13275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GZL_RS13285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZL_RS13305	COG2205	protein histidine kinase activity
GZL_RS13315	COG1126	abc transporter atp-binding protein
GZL_RS13325	COG4597	amino acid ABC transporter
GZL_RS13330	COG0765	amino acid transport
GZL_RS13335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS13345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZL_RS13360	COG0628	permease
GZL_RS13375	COG1316	TRANSCRIPTIONal
GZL_RS13380	COG0640	Transcriptional regulator
GZL_RS13425	COG1201	RNA secondary structure unwinding
GZL_RS13430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZL_RS13440	COG0783	Belongs to the Dps family
GZL_RS13445	COG1396	sequence-specific DNA binding
GZL_RS13450	COG1058	Belongs to the CinA family
GZL_RS13450	COG1546	Belongs to the CinA family
GZL_RS13460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZL_RS13470	COG1674	ftsk spoiiie
GZL_RS13480	COG4999	Histidine kinase
GZL_RS13480	COG3850	Histidine kinase
GZL_RS13480	COG3437	response regulator, receiver
GZL_RS13480	COG2205	protein histidine kinase activity
GZL_RS13515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GZL_RS13520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZL_RS13525	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GZL_RS13545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GZL_RS13550	COG0612	Peptidase, M16
GZL_RS13555	COG1185	polyribonucleotide nucleotidyltransferase activity
GZL_RS13560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZL_RS13570	COG1674	ftsk spoiiie
GZL_RS13690	COG1404	Belongs to the peptidase S8 family
GZL_RS13720	COG0455	bacterial-type flagellum organization
GZL_RS13735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZL_RS13740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZL_RS13750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZL_RS13770	COG0779	Required for maturation of 30S ribosomal subunits
GZL_RS13785	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GZL_RS13790	COG0442	prolyl-tRNA aminoacylation
GZL_RS13805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZL_RS13810	COG0750	zinc metalloprotease
GZL_RS13815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZL_RS13815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZL_RS13825	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS13830	COG2508	Transcriptional regulator
GZL_RS13855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZL_RS13860	COG1177	transmembrane transport
GZL_RS13865	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZL_RS13870	COG3547	Transposase (IS116 IS110 IS902 family)
GZL_RS13875	COG3842	ATPase activity
GZL_RS13885	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS13895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZL_RS13910	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS13920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZL_RS13955	COG0438	transferase activity, transferring glycosyl groups
GZL_RS13965	COG4585	Histidine kinase
GZL_RS13970	COG2197	response regulator
GZL_RS13975	COG3842	ATPase activity
GZL_RS13980	COG4208	sulfate ABC transporter
GZL_RS13990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GZL_RS14000	COG0233	cytoplasmic translational termination
GZL_RS14005	COG0528	UMP kinase activity
GZL_RS14010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZL_RS14015	COG0052	Belongs to the universal ribosomal protein uS2 family
GZL_RS14025	COG1191	sigma factor activity
GZL_RS14040	COG0792	nuclease activity
GZL_RS14055	COG0681	Belongs to the peptidase S26 family
GZL_RS14060	COG0681	Belongs to the peptidase S26 family
GZL_RS14070	COG0681	Belongs to the peptidase S26 family
GZL_RS14075	COG0335	large ribosomal subunit rRNA binding
GZL_RS14080	COG0336	Belongs to the RNA methyltransferase TrmD family
GZL_RS14085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZL_RS14090	COG1837	Belongs to the UPF0109 family
GZL_RS14095	COG0228	four-way junction DNA binding
GZL_RS14150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZL_RS14165	COG0477	Major facilitator Superfamily
GZL_RS14170	COG1196	nuclear chromosome segregation
GZL_RS14180	COG1254	Belongs to the acylphosphatase family
GZL_RS14190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZL_RS14195	COG0571	ribonuclease III activity
GZL_RS14200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GZL_RS14215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GZL_RS14220	COG0742	ribosomal rna small subunit methyltransferase
GZL_RS14230	COG1461	Dihydroxyacetone kinase
GZL_RS14235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZL_RS14240	COG0351	phosphomethylpyrimidine kinase
GZL_RS14260	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZL_RS14265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZL_RS14275	COG1920	GTP binding
GZL_RS14285	COG0776	regulation of translation
GZL_RS14295	COG0066	3-isopropylmalate dehydratase activity
GZL_RS14300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GZL_RS14305	COG1414	Transcriptional regulator
GZL_RS14330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZL_RS14335	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZL_RS14350	COG2018	Roadblock/LC7 domain
GZL_RS14370	COG2018	Roadblock/LC7 domain
GZL_RS14395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZL_RS14400	COG5492	domain, Protein
GZL_RS14405	COG2353	YceI-like domain
GZL_RS14410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZL_RS14415	COG0477	Major facilitator Superfamily
GZL_RS14420	COG1309	transcriptional regulator
GZL_RS14425	COG2957	Belongs to the agmatine deiminase family
GZL_RS14430	COG0804	urea catabolic process
GZL_RS14435	COG0831	urea catabolic process
GZL_RS14435	COG0832	Belongs to the urease beta subunit family
GZL_RS14445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZL_RS14450	COG0473	3-isopropylmalate dehydrogenase activity
GZL_RS14460	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS14465	COG0506	proline dehydrogenase activity
GZL_RS14470	COG3835	regulator
GZL_RS14490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZL_RS14495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZL_RS14500	COG0440	acetolactate synthase activity
GZL_RS14520	COG0667	Aldo Keto reductase
GZL_RS14525	COG2133	pyrroloquinoline quinone binding
GZL_RS14530	COG1672	PFAM Archaeal ATPase
GZL_RS14530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GZL_RS14545	COG2409	Drug exporters of the RND superfamily
GZL_RS14550	COG3511	phospholipase C
GZL_RS14570	COG0667	Aldo Keto reductase
GZL_RS14580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZL_RS14590	COG0154	amidase activity
GZL_RS14595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZL_RS14605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZL_RS14615	COG0477	Major facilitator Superfamily
GZL_RS14625	COG4221	oxidoreductase activity
GZL_RS14630	COG1611	Belongs to the LOG family
GZL_RS14635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GZL_RS14660	COG0482	sulfurtransferase activity
GZL_RS14680	COG2860	membrane
GZL_RS14685	COG0308	aminopeptidase N
GZL_RS14690	COG4608	Belongs to the ABC transporter superfamily
GZL_RS14695	COG0444	Belongs to the ABC transporter superfamily
GZL_RS14700	COG0601	transmembrane transport
GZL_RS14705	COG0747	negative chemotaxis
GZL_RS14730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GZL_RS14735	COG0509	glycine decarboxylation via glycine cleavage system
GZL_RS14740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZL_RS14745	COG1760	l-serine dehydratase
GZL_RS14755	COG0671	phosphoesterase, PA-phosphatase related
GZL_RS14765	COG0586	Pfam SNARE associated Golgi protein
GZL_RS14780	COG2205	protein histidine kinase activity
GZL_RS14785	COG0745	RESPONSE REGULATOR receiver
GZL_RS14800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GZL_RS14810	COG0785	Cytochrome C biogenesis protein
GZL_RS14815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GZL_RS14815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZL_RS14835	COG1376	ErfK ybiS ycfS ynhG family protein
GZL_RS14850	COG1132	(ABC) transporter
GZL_RS14855	COG1132	(ABC) transporter
GZL_RS14870	COG0366	Alpha amylase catalytic
GZL_RS14875	COG0366	Alpha amylase catalytic
GZL_RS14885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GZL_RS14890	COG1301	dicarboxylic acid transport
GZL_RS14895	COG3290	protein histidine kinase activity
GZL_RS14900	COG4565	transcriptional regulatory protein
GZL_RS14910	COG1175	transmembrane transport
GZL_RS14915	COG0395	ABC-type sugar transport system, permease component
GZL_RS14925	COG0577	efflux transmembrane transporter activity
GZL_RS14925	COG1136	(ABC) transporter
GZL_RS14930	COG0577	efflux transmembrane transporter activity
GZL_RS14940	COG0205	6-phosphofructokinase activity
GZL_RS14945	COG0280	phosphate acetyltransferase
GZL_RS14945	COG0857	belongs to the CobB CobQ family
GZL_RS14950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZL_RS14990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZL_RS14995	COG0745	RESPONSE REGULATOR receiver
GZL_RS15005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZL_RS15005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZL_RS15065	COG0183	Belongs to the thiolase family
GZL_RS15085	COG1131	(ABC) transporter
GZL_RS15120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GZL_RS15135	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS15150	COG4585	Histidine kinase
GZL_RS15155	COG2197	response regulator
GZL_RS15165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZL_RS15170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZL_RS15175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZL_RS15180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZL_RS15185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZL_RS15190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GZL_RS15195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZL_RS15215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZL_RS15220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZL_RS15230	COG2890	protein-(glutamine-N5) methyltransferase activity
GZL_RS15235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GZL_RS15240	COG0254	rRNA binding
GZL_RS15255	COG0083	homoserine kinase activity
GZL_RS15260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GZL_RS15265	COG0460	homoserine dehydrogenase
GZL_RS15270	COG0019	diaminopimelate decarboxylase activity
GZL_RS15275	COG0018	arginyl-trna synthetase
GZL_RS15290	COG2124	cytochrome p450
GZL_RS15300	COG0768	penicillin binding
GZL_RS15310	COG1119	ATPase activity
GZL_RS15390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GZL_RS15395	COG1357	PFAM Pentapeptide repeats (8 copies)
GZL_RS15410	COG0745	RESPONSE REGULATOR receiver
GZL_RS15415	COG2205	protein histidine kinase activity
GZL_RS15420	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZL_RS15420	COG0567	Dehydrogenase, E1 component
GZL_RS15465	COG0604	alcohol dehydrogenase
GZL_RS15470	COG0281	malic enzyme
GZL_RS15475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZL_RS15480	COG0765	amino acid transport
GZL_RS15485	COG1126	abc transporter atp-binding protein
GZL_RS15515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZL_RS15520	COG1993	acr, cog1993
GZL_RS15525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZL_RS15530	COG2186	Transcriptional regulator
GZL_RS15535	COG2807	transmembrane transport
GZL_RS15540	COG0598	Magnesium transport protein CorA
GZL_RS15545	COG0477	Major facilitator Superfamily
GZL_RS15560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS15575	COG2066	Belongs to the glutaminase family
GZL_RS15590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GZL_RS15625	COG1597	lipid kinase activity
GZL_RS15640	COG1309	transcriptional regulator
GZL_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS15650	COG0363	glucosamine-6-phosphate deaminase activity
GZL_RS15655	COG1472	Belongs to the glycosyl hydrolase 3 family
GZL_RS15660	COG0395	ABC-type sugar transport system, permease component
GZL_RS15665	COG1175	transmembrane transport
GZL_RS15670	COG2182	Extracellular solute-binding protein
GZL_RS15675	COG2188	Transcriptional regulator
GZL_RS15700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZL_RS15705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZL_RS15710	COG0242	peptide deformylase activity
GZL_RS15725	COG5662	AntiSigma factor
GZL_RS15730	COG1595	DNA-templated transcription, initiation
GZL_RS15740	COG2135	peptidase activity
GZL_RS15750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GZL_RS15755	COG1162	GTPase activity
GZL_RS15760	COG2076	Multidrug Resistance protein
GZL_RS15770	COG0483	inositol monophosphate 1-phosphatase activity
GZL_RS15780	COG0753	catalase activity
GZL_RS15810	COG1615	UPF0182 protein
GZL_RS15820	COG3480	Lon protease (S16) C-terminal proteolytic domain
GZL_RS15865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZL_RS15905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZL_RS15910	COG0210	DNA helicase
GZL_RS15915	COG0210	DNA helicase
GZL_RS15955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GZL_RS15955	COG0596	Alpha beta hydrolase
GZL_RS15985	COG0513	Belongs to the DEAD box helicase family
GZL_RS15995	COG1432	Conserved Protein
GZL_RS16000	COG2095	MarC family integral membrane protein
GZL_RS16020	COG0598	Magnesium transport protein CorA
GZL_RS16055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZL_RS16060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZL_RS16070	COG1595	DNA-templated transcription, initiation
GZL_RS16075	COG4122	O-methyltransferase activity
GZL_RS16080	COG1024	Enoyl-CoA hydratase
GZL_RS16085	COG0519	Catalyzes the synthesis of GMP from XMP
GZL_RS16095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZL_RS16100	COG1611	Belongs to the LOG family
GZL_RS16105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZL_RS16145	COG2197	response regulator
GZL_RS16150	COG4585	Histidine kinase
GZL_RS16160	COG1131	(ABC) transporter
GZL_RS16175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZL_RS16190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZL_RS16195	COG0747	negative chemotaxis
GZL_RS16205	COG0444	Belongs to the ABC transporter superfamily
GZL_RS16210	COG4608	Belongs to the ABC transporter superfamily
GZL_RS16215	COG4608	Belongs to the ABC transporter superfamily
GZL_RS16220	COG0444	Belongs to the ABC transporter superfamily
GZL_RS16225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZL_RS16230	COG0601	transmembrane transport
GZL_RS16235	COG0747	negative chemotaxis
GZL_RS16240	COG1217	gtp-binding protein TYPA
GZL_RS16260	COG1053	succinate dehydrogenase
GZL_RS16270	COG0402	S-adenosylhomocysteine deaminase activity
GZL_RS16295	COG0531	amino acid
GZL_RS16325	COG0012	GTP binding
GZL_RS16340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZL_RS16345	COG1113	amino acid transport
GZL_RS16350	COG1570	exodeoxyribonuclease VII activity
GZL_RS16355	COG1722	exodeoxyribonuclease VII activity
GZL_RS16360	COG0778	Nitroreductase
GZL_RS16385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GZL_RS16385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GZL_RS16415	COG0114	fumarate hydratase activity
GZL_RS16435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZL_RS16450	COG1136	(ABC) transporter
GZL_RS16465	COG1136	(ABC) transporter
GZL_RS16485	COG0450	alkyl hydroperoxide reductase
GZL_RS16490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZL_RS16500	COG0741	lytic transglycosylase activity
GZL_RS16505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GZL_RS16510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZL_RS16515	COG0667	Aldo Keto reductase
GZL_RS16620	COG2610	gluconate transmembrane transporter activity
GZL_RS16625	COG0251	oxidation-reduction process
GZL_RS16630	COG1414	Transcriptional regulator
GZL_RS16645	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GZL_RS16660	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GZL_RS16680	COG0154	amidase activity
GZL_RS16685	COG2130	NADP-dependent
GZL_RS16690	COG1331	Highly conserved protein containing a thioredoxin domain
GZL_RS16700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GZL_RS16705	COG0022	dehydrogenase e1 component
GZL_RS16710	COG0667	Aldo Keto reductase
GZL_RS16715	COG1472	Belongs to the glycosyl hydrolase 3 family
GZL_RS16820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZL_RS16830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZL_RS16845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GZL_RS16865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZL_RS16910	COG2986	histidine ammonia-lyase
GZL_RS16920	COG1024	Enoyl-CoA hydratase
GZL_RS16925	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GZL_RS16935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZL_RS16945	COG0768	penicillin binding
GZL_RS16955	COG0424	maF-like protein
GZL_RS16975	COG4770	biotin carboxylase activity
GZL_RS17010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZL_RS17030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GZL_RS17035	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS17040	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS17055	COG1595	DNA-templated transcription, initiation
GZL_RS17060	COG0745	RESPONSE REGULATOR receiver
GZL_RS17065	COG2205	protein histidine kinase activity
GZL_RS17090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZL_RS17100	COG0583	DNA-binding transcription factor activity
GZL_RS17105	COG2814	Major facilitator Superfamily
GZL_RS17155	COG1079	Belongs to the binding-protein-dependent transport system permease family
GZL_RS17160	COG4603	Belongs to the binding-protein-dependent transport system permease family
GZL_RS17165	COG3845	ABC transporter
GZL_RS17170	COG1744	ABC transporter substrate-binding protein PnrA-like
GZL_RS17175	COG1473	amidohydrolase
GZL_RS17175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GZL_RS17185	COG2089	acid synthase
GZL_RS17200	COG1216	Glycosyl transferase, family 2
GZL_RS17210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GZL_RS17240	COG3265	gluconokinase activity
GZL_RS17255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZL_RS17255	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZL_RS17280	COG2009	succinate dehydrogenase
GZL_RS17290	COG1053	succinate dehydrogenase
GZL_RS17295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZL_RS17335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZL_RS17340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZL_RS17345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZL_RS17355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZL_RS17360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZL_RS17365	COG0180	Tryptophanyl-tRNA synthetase
GZL_RS17375	COG1295	ribonuclease BN
GZL_RS17395	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZL_RS17450	COG4176	ABC-type proline glycine betaine transport system permease component
GZL_RS17455	COG0517	IMP dehydrogenase activity
GZL_RS17455	COG4175	Glycine betaine
GZL_RS17465	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS17500	COG0039	L-malate dehydrogenase activity
GZL_RS17505	COG0538	isocitrate dehydrogenase activity
GZL_RS17515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZL_RS17530	COG0138	bifunctional purine biosynthesis protein purh
GZL_RS17560	COG0045	succinate-CoA ligase (ADP-forming) activity
GZL_RS17670	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GZL_RS17680	COG0714	Associated with various cellular activities
GZL_RS17695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZL_RS17705	COG0739	heme binding
GZL_RS17735	COG2197	response regulator
GZL_RS17745	COG0515	serine threonine protein kinase
GZL_RS17790	COG0519	Catalyzes the synthesis of GMP from XMP
GZL_RS17790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZL_RS17810	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS17815	COG0515	serine threonine protein kinase
GZL_RS17895	COG1131	(ABC) transporter
GZL_RS17905	COG0477	Major facilitator Superfamily
GZL_RS17925	COG2945	thiolester hydrolase activity
GZL_RS17925	COG0596	Alpha beta hydrolase
GZL_RS17935	COG4821	SIS domain
GZL_RS17945	COG0259	pyridoxamine-phosphate oxidase activity
GZL_RS17955	COG1309	transcriptional regulator
GZL_RS17965	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS17980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZL_RS18020	COG5006	permease, DMT superfamily
GZL_RS18025	COG0583	DNA-binding transcription factor activity
GZL_RS18035	COG0277	FAD linked oxidase domain protein
GZL_RS18035	COG0247	lactate metabolic process
GZL_RS18055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GZL_RS18075	COG0667	Aldo Keto reductase
GZL_RS18100	COG2252	PERMEase
GZL_RS18110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GZL_RS18115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZL_RS18135	COG2814	Major facilitator Superfamily
GZL_RS18145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZL_RS18150	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GZL_RS18155	COG1278	Cold shock
GZL_RS18170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS18175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS18180	COG1120	ATPase activity
GZL_RS18185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZL_RS18200	COG1061	Type III restriction enzyme res subunit
GZL_RS18215	COG3973	AAA domain
GZL_RS18230	COG3142	Participates in the control of copper homeostasis
GZL_RS18245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZL_RS18275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZL_RS18280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZL_RS18280	COG1263	PTS System
GZL_RS18315	COG1278	Cold shock
GZL_RS18330	COG0463	Glycosyl transferase, family 2
GZL_RS18340	COG3336	cytochrome c oxidase
GZL_RS18370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZL_RS18395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GZL_RS18515	COG3842	ATPase activity
GZL_RS18525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZL_RS18540	COG0215	cysteine-tRNA ligase activity
GZL_RS18545	COG3467	pyridoxamine 5'-phosphate
GZL_RS18550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GZL_RS18555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZL_RS18560	COG1329	Transcriptional regulator
GZL_RS18575	COG5002	protein histidine kinase activity
GZL_RS18585	COG0588	phosphoglycerate mutase activity
GZL_RS18615	COG0438	transferase activity, transferring glycosyl groups
GZL_RS18630	COG0494	nUDIX hydrolase
GZL_RS18630	COG0406	alpha-ribazole phosphatase activity
GZL_RS18640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GZL_RS18645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZL_RS18650	COG0456	acetyltransferase
GZL_RS18655	COG0737	Belongs to the 5'-nucleotidase family
GZL_RS18710	COG2205	protein histidine kinase activity
GZL_RS18715	COG0745	RESPONSE REGULATOR receiver
GZL_RS18720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZL_RS18725	COG1609	Transcriptional regulator
GZL_RS18730	COG0745	RESPONSE REGULATOR receiver
GZL_RS18760	COG2897	thiosulfate sulfurtransferase activity
GZL_RS18785	COG3485	protocatechuate 3,4-dioxygenase
GZL_RS18790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS18795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GZL_RS18815	COG1490	D-aminoacyl-tRNA deacylase activity
GZL_RS18835	COG0431	NADPH-dependent FMN reductase
GZL_RS18840	COG1733	regulation of RNA biosynthetic process
GZL_RS18845	COG0346	lactoylglutathione lyase activity
GZL_RS18860	COG0667	Aldo Keto reductase
GZL_RS18875	COG2890	protein-(glutamine-N5) methyltransferase activity
GZL_RS18890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZL_RS18895	COG0754	glutathionylspermidine amidase activity
GZL_RS18925	COG0791	NLP P60 protein
GZL_RS18930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GZL_RS18950	COG0306	phosphate transporter
GZL_RS18960	COG1937	Protein conserved in bacteria
GZL_RS18980	COG0277	FAD linked oxidase domain protein
GZL_RS18985	COG0671	phosphoesterase, PA-phosphatase related
GZL_RS18990	COG0739	heme binding
GZL_RS18990	COG0741	lytic transglycosylase activity
GZL_RS18990	COG1196	nuclear chromosome segregation
GZL_RS19060	COG0180	Tryptophanyl-tRNA synthetase
GZL_RS19065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZL_RS19070	COG0308	aminopeptidase N
GZL_RS19075	COG1595	DNA-templated transcription, initiation
GZL_RS19100	COG0515	serine threonine protein kinase
GZL_RS19100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZL_RS19125	COG0129	dihydroxy-acid dehydratase activity
GZL_RS19130	COG1082	Xylose isomerase domain protein TIM barrel
GZL_RS19135	COG0248	Ppx GppA phosphatase
GZL_RS19155	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GZL_RS19175	COG1194	a g-specific adenine glycosylase
GZL_RS19180	COG1595	DNA-templated transcription, initiation
GZL_RS19190	COG0745	RESPONSE REGULATOR receiver
GZL_RS19195	COG2205	protein histidine kinase activity
GZL_RS19230	COG0739	heme binding
GZL_RS19250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GZL_RS19270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GZL_RS19280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GZL_RS19285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GZL_RS19295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GZL_RS19305	COG0640	Transcriptional regulator
GZL_RS19330	COG0649	NAD binding
GZL_RS19345	COG1174	glycine betaine transport
GZL_RS19350	COG1174	glycine betaine transport
GZL_RS19365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZL_RS19370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GZL_RS19395	COG0302	gtp cyclohydrolase
GZL_RS19410	COG0037	tRNA processing
GZL_RS19420	COG2027	D-alanyl-D-alanine carboxypeptidase
GZL_RS19425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GZL_RS19460	COG2226	methyltransferase
GZL_RS19470	COG1132	(ABC) transporter
GZL_RS19480	COG0586	Pfam SNARE associated Golgi protein
GZL_RS19485	COG0393	Putative heavy-metal-binding
GZL_RS19495	COG0655	NAD(P)H dehydrogenase (quinone) activity
GZL_RS19500	COG0076	glutamate decarboxylase activity
GZL_RS19510	COG2318	DinB family
GZL_RS19515	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS19545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GZL_RS19555	COG0254	rRNA binding
GZL_RS19560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZL_RS19565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZL_RS19570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZL_RS19580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GZL_RS19580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZL_RS19625	COG0657	acetylesterase activity
GZL_RS19645	COG3594	Acyltransferase
GZL_RS19650	COG0584	glycerophosphoryl diester phosphodiesterase
GZL_RS19660	COG2124	cytochrome p450
GZL_RS19695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZL_RS19700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZL_RS19705	COG1754	DNA topoisomerase type I activity
GZL_RS19705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZL_RS19725	COG2890	protein-(glutamine-N5) methyltransferase activity
GZL_RS19735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GZL_RS19745	COG1366	Belongs to the anti-sigma-factor antagonist family
GZL_RS19750	COG1205	dead DEAH box helicase
GZL_RS19750	COG1111	helicase
GZL_RS19810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZL_RS19815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GZL_RS19825	COG2267	carboxylic ester hydrolase activity
GZL_RS19855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZL_RS19875	COG0003	Pfam Anion-transporting ATPase
GZL_RS19885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GZL_RS19895	COG1408	metallophosphoesterase
GZL_RS19910	COG0339	signal peptide processing
GZL_RS19940	COG1595	DNA-templated transcription, initiation
GZL_RS19960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZL_RS19965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZL_RS20035	COG0105	UTP biosynthetic process
GZL_RS20125	COG2188	Transcriptional regulator
GZL_RS20160	COG1132	(ABC) transporter
GZL_RS20170	COG2208	phosphoserine phosphatase activity
GZL_RS20170	COG2172	sigma factor antagonist activity
GZL_RS20170	COG1366	Belongs to the anti-sigma-factor antagonist family
GZL_RS20195	COG0477	Major facilitator Superfamily
GZL_RS20200	COG2188	Transcriptional regulator
GZL_RS20210	COG1834	amidinotransferase
GZL_RS20215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZL_RS20240	COG3209	COG3209 Rhs family protein
GZL_RS20280	COG0477	Major facilitator Superfamily
GZL_RS20290	COG2268	Band 7 protein
GZL_RS20320	COG1064	alcohol dehydrogenase
GZL_RS20330	COG0523	cobalamin synthesis protein
GZL_RS20365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GZL_RS20375	COG0590	tRNA wobble adenosine to inosine editing
GZL_RS20400	COG1191	sigma factor activity
GZL_RS20405	COG1191	sigma factor activity
GZL_RS20435	COG2353	YceI-like domain
GZL_RS20455	COG0477	Major facilitator Superfamily
GZL_RS20460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GZL_RS20470	COG2205	protein histidine kinase activity
GZL_RS20475	COG0745	RESPONSE REGULATOR receiver
GZL_RS20480	COG1053	succinate dehydrogenase
GZL_RS20480	COG0431	NADPH-dependent FMN reductase
GZL_RS20480	COG3976	FMN-binding domain protein
GZL_RS20530	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS20540	COG2205	protein histidine kinase activity
GZL_RS20540	COG3850	Histidine kinase
GZL_RS20540	COG4999	Histidine kinase
GZL_RS20540	COG3437	response regulator, receiver
GZL_RS20545	COG3437	response regulator, receiver
GZL_RS20550	COG2318	DinB family
GZL_RS20580	COG1595	DNA-templated transcription, initiation
GZL_RS20605	COG1960	acyl-CoA dehydrogenase activity
GZL_RS20615	COG1960	acyl-CoA dehydrogenase activity
GZL_RS20655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZL_RS20670	COG0653	protein targeting
GZL_RS20690	COG0006	proline dipeptidase activity
GZL_RS20780	COG2372	response to copper ion
GZL_RS20785	COG2837	iron assimilation
GZL_RS20795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZL_RS20800	COG0561	phosphatase activity
GZL_RS20840	COG2186	Transcriptional regulator
GZL_RS20845	COG2807	transmembrane transport
GZL_RS20890	COG0789	Transcriptional regulator
GZL_RS20895	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GZL_RS20910	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GZL_RS20920	COG0501	Belongs to the peptidase M48B family
GZL_RS20930	COG0561	phosphatase activity
GZL_RS20940	COG4988	ABC transporter
GZL_RS20945	COG1294	oxidase, subunit
GZL_RS20950	COG1271	oxidase subunit
GZL_RS20960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZL_RS20965	COG1609	Transcriptional regulator
GZL_RS20970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZL_RS20980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GZL_RS21005	COG0662	Cupin 2, conserved barrel domain protein
GZL_RS21010	COG1950	PFAM Membrane protein of
GZL_RS21015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZL_RS21020	COG0626	cystathionine gamma-synthase activity
GZL_RS21055	COG2814	Major facilitator Superfamily
GZL_RS21085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZL_RS21095	COG4978	Transcriptional regulator
GZL_RS21095	COG0789	Transcriptional regulator
GZL_RS21105	COG1309	transcriptional regulator
GZL_RS21110	COG0305	Participates in initiation and elongation during chromosome replication
GZL_RS21115	COG0534	Mate efflux family protein
GZL_RS21125	COG0359	binds to the 23S rRNA
GZL_RS21130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GZL_RS21135	COG0629	single-stranded DNA binding
GZL_RS21140	COG0360	Binds together with S18 to 16S ribosomal RNA
GZL_RS21165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GZL_RS21175	COG1260	myo-inositol-1-phosphate synthase
GZL_RS21185	COG0617	tRNA 3'-terminal CCA addition
GZL_RS21195	COG0728	peptidoglycan biosynthetic process
GZL_RS21200	COG2815	serine threonine protein kinase
GZL_RS21200	COG0515	serine threonine protein kinase
GZL_RS21205	COG1595	DNA-templated transcription, initiation
GZL_RS21215	COG0492	ferredoxin-NADP+ reductase activity
GZL_RS21220	COG3118	belongs to the thioredoxin family
GZL_RS21235	COG1192	Involved in chromosome partitioning
GZL_RS21240	COG0357	Ribosomal RNA small subunit methyltransferase G
GZL_RS21250	COG0706	membrane insertase activity
GZL_RS21255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GZL_RS21260	COG0594	ribonuclease P activity
GZL_RS21265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GZL_RS21275	COG0592	DNA-directed DNA polymerase activity
GZL_RS21280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GZL_RS21285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZL_RS21290	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GZL_RS21295	COG0187	DNA topoisomerase II activity
GZL_RS21300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZL_RS21320	COG0515	serine threonine protein kinase
GZL_RS21340	COG0583	DNA-binding transcription factor activity
GZL_RS21355	COG0705	Rhomboid family
GZL_RS21370	COG3764	Sortase (surface protein transpeptidase)
GZL_RS21385	COG3764	Sortase (surface protein transpeptidase)
GZL_RS21390	COG3764	Sortase (surface protein transpeptidase)
GZL_RS21395	COG0515	serine threonine protein kinase
GZL_RS21400	COG0768	penicillin binding
GZL_RS21415	COG1716	ATPase activity
GZL_RS21420	COG1716	ATPase activity
GZL_RS21430	COG0583	DNA-binding transcription factor activity
GZL_RS21435	COG2814	Major facilitator Superfamily
GZL_RS21440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZL_RS21445	COG1733	regulation of RNA biosynthetic process
GZL_RS21480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZL_RS21485	COG2151	metal-sulfur cluster biosynthetic enzyme
GZL_RS21490	COG3396	Phenylacetate-CoA oxygenase
GZL_RS21495	COG3460	Phenylacetate-CoA oxygenase
GZL_RS21500	COG3396	Phenylacetate-CoA oxygenase
GZL_RS21525	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS21530	COG1309	transcriptional regulator
GZL_RS21535	COG1522	sequence-specific DNA binding
GZL_RS21555	COG0746	molybdenum cofactor guanylyltransferase activity
GZL_RS21565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GZL_RS21585	COG0515	serine threonine protein kinase
GZL_RS21590	COG0515	serine threonine protein kinase
GZL_RS21615	COG0022	dehydrogenase e1 component
GZL_RS21620	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZL_RS21640	COG2271	Major facilitator Superfamily
GZL_RS21680	COG3903	Transcriptional regulator
GZL_RS21680	COG3629	intracellular signal transduction
GZL_RS21685	COG1362	aminopeptidase activity
GZL_RS21690	COG1960	acyl-CoA dehydrogenase activity
GZL_RS21715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZL_RS21720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZL_RS21740	COG1174	glycine betaine transport
GZL_RS21745	COG3547	Transposase (IS116 IS110 IS902 family)
GZL_RS21750	COG1174	glycine betaine transport
GZL_RS21760	COG1125	glycine betaine transport
GZL_RS21760	COG0517	IMP dehydrogenase activity
GZL_RS21785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZL_RS21850	COG1316	TRANSCRIPTIONal
GZL_RS21925	COG0662	Cupin 2, conserved barrel domain protein
GZL_RS21945	COG2301	Belongs to the HpcH HpaI aldolase family
GZL_RS21955	COG0717	Belongs to the dCTP deaminase family
GZL_RS21975	COG0247	lactate metabolic process
GZL_RS21975	COG2181	nitrate reductase activity
GZL_RS21980	COG0443	Heat shock 70 kDa protein
GZL_RS21985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GZL_RS21990	COG0484	heat shock protein binding
GZL_RS21995	COG0789	Transcriptional regulator
GZL_RS22015	COG0542	response to heat
GZL_RS22040	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GZL_RS22055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZL_RS22060	COG0191	fructose-bisphosphate aldolase activity
GZL_RS22065	COG0477	Major facilitator Superfamily
GZL_RS22080	COG3844	kynureninase activity
GZL_RS22090	COG4585	Histidine kinase
GZL_RS22095	COG2197	response regulator
GZL_RS22100	COG3559	Exporter of polyketide antibiotics
GZL_RS22105	COG1131	(ABC) transporter
GZL_RS22120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZL_RS22125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZL_RS22125	COG0515	serine threonine protein kinase
GZL_RS22135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GZL_RS22140	COG1802	Transcriptional regulator
GZL_RS22155	COG0151	Belongs to the GarS family
GZL_RS22175	COG0583	DNA-binding transcription factor activity
GZL_RS22185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZL_RS22210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZL_RS22215	COG0047	phosphoribosylformylglycinamidine synthase activity
GZL_RS22220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZL_RS22235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZL_RS22270	COG1643	Atp-dependent helicase
GZL_RS22310	COG0513	Belongs to the DEAD box helicase family
GZL_RS22320	COG2814	Major facilitator Superfamily
GZL_RS22335	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GZL_RS22400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZL_RS22405	COG0579	oxidoreductase
GZL_RS22430	COG1252	NADH dehydrogenase
GZL_RS22465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZL_RS22475	COG0123	including yeast histone deacetylase and acetoin utilization protein
GZL_RS22520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GZL_RS22525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GZL_RS22530	COG0181	hydroxymethylbilane synthase activity
GZL_RS22535	COG1648	precorrin-2 dehydrogenase activity
GZL_RS22535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZL_RS22540	COG0113	porphobilinogen synthase activity
GZL_RS22570	COG0018	arginyl-trna synthetase
GZL_RS22575	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GZL_RS22600	COG1690	Belongs to the RtcB family
GZL_RS22605	COG1846	Transcriptional regulator
GZL_RS22625	COG1742	UPF0060 membrane protein
GZL_RS22630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS22650	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS22660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GZL_RS22665	COG0406	alpha-ribazole phosphatase activity
GZL_RS22680	COG0785	Cytochrome C biogenesis protein
GZL_RS22685	COG1333	cytochrome c biogenesis protein
GZL_RS22690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZL_RS22720	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GZL_RS22725	COG0109	protoheme IX farnesyltransferase activity
GZL_RS22740	COG0163	prenyltransferase activity
GZL_RS22750	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GZL_RS22765	COG1301	dicarboxylic acid transport
GZL_RS22775	COG1309	transcriptional regulator
GZL_RS22790	COG1278	Cold shock
GZL_RS22795	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GZL_RS22800	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GZL_RS22810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GZL_RS22820	COG2226	methyltransferase
GZL_RS22865	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZL_RS22870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZL_RS22875	COG0649	NAD binding
GZL_RS22885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GZL_RS22890	COG1034	ATP synthesis coupled electron transport
GZL_RS22895	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GZL_RS22900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZL_RS22905	COG0839	Belongs to the complex I subunit 6 family
GZL_RS22910	COG0713	ATP synthesis coupled electron transport
GZL_RS22915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZL_RS22925	COG1007	ATP synthesis coupled electron transport
GZL_RS22940	COG0142	geranyltranstransferase activity
GZL_RS22965	COG1013	pyruvate-flavodoxin oxidoreductase activity
GZL_RS22970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GZL_RS22970	COG0674	pyruvate-flavodoxin oxidoreductase activity
GZL_RS22980	COG4585	Histidine kinase
GZL_RS22985	COG4585	Histidine kinase
GZL_RS23010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GZL_RS23015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZL_RS23025	COG0713	ATP synthesis coupled electron transport
GZL_RS23040	COG1007	ATP synthesis coupled electron transport
GZL_RS23045	COG0501	Belongs to the peptidase M48B family
GZL_RS23050	COG3304	Inner membrane component domain
GZL_RS23060	COG1666	GTP binding
GZL_RS23080	COG0702	epimerase
GZL_RS23100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZL_RS23105	COG2030	dehydratase
GZL_RS23115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZL_RS23120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZL_RS23125	COG0436	Aminotransferase
GZL_RS23140	COG0250	Participates in transcription elongation, termination and antitermination
GZL_RS23145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZL_RS23150	COG0081	regulation of translation
GZL_RS23165	COG0222	ribosome binding
GZL_RS23170	COG0085	RNA polymerase activity
GZL_RS23175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZL_RS23185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZL_RS23190	COG0049	tRNA binding
GZL_RS23195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZL_RS23200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZL_RS23205	COG0051	transcription antitermination factor activity, RNA binding
GZL_RS23210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZL_RS23215	COG0088	Forms part of the polypeptide exit tunnel
GZL_RS23220	COG0089	rRNA binding
GZL_RS23225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZL_RS23230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZL_RS23235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZL_RS23240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZL_RS23245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZL_RS23250	COG0255	Belongs to the universal ribosomal protein uL29 family
GZL_RS23255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GZL_RS23260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZL_RS23265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZL_RS23270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZL_RS23275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZL_RS23280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZL_RS23285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZL_RS23290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GZL_RS23295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZL_RS23300	COG1841	ribosomal large subunit assembly
GZL_RS23305	COG0200	Binds to the 23S rRNA
GZL_RS23315	COG0563	adenylate kinase activity
GZL_RS23325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZL_RS23330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZL_RS23335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZL_RS23340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZL_RS23345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZL_RS23350	COG0202	RNA polymerase activity
GZL_RS23355	COG0203	ribosomal protein L17
GZL_RS23360	COG0101	tRNA pseudouridine synthase activity
GZL_RS23370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZL_RS23375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GZL_RS23380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZL_RS23385	COG1072	(Pantothenic acid kinase))
GZL_RS23395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZL_RS23400	COG0736	holo-[acyl-carrier-protein] synthase activity
GZL_RS23410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZL_RS23420	COG0802	atpase or kinase
GZL_RS23435	COG0456	acetyltransferase
GZL_RS23435	COG1214	PFAM Peptidase M22, glycoprotease
GZL_RS23445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZL_RS23460	COG0772	Belongs to the SEDS family
GZL_RS23465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZL_RS23470	COG0459	protein refolding
GZL_RS23475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZL_RS23480	COG4221	oxidoreductase activity
GZL_RS23490	COG0583	DNA-binding transcription factor activity
GZL_RS23500	COG2197	response regulator
GZL_RS23505	COG1595	DNA-templated transcription, initiation
GZL_RS23515	COG0516	GMP reductase activity
GZL_RS23525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GZL_RS23545	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS23550	COG1960	acyl-CoA dehydrogenase activity
GZL_RS23555	COG1960	acyl-CoA dehydrogenase activity
GZL_RS23570	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS23575	COG1960	acyl-CoA dehydrogenase activity
GZL_RS23600	COG1024	Enoyl-CoA hydratase
GZL_RS23605	COG0045	succinate-CoA ligase (ADP-forming) activity
GZL_RS23605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZL_RS23605	COG1042	CoA-binding domain protein
GZL_RS23620	COG0259	pyridoxamine-phosphate oxidase activity
GZL_RS23630	COG1960	acyl-CoA dehydrogenase activity
GZL_RS23640	COG1309	transcriptional regulator
GZL_RS23645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZL_RS23645	COG0515	serine threonine protein kinase
GZL_RS23665	COG1024	Enoyl-CoA hydratase
GZL_RS23695	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS23765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GZL_RS23785	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS23795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZL_RS23820	COG1686	Belongs to the peptidase S11 family
GZL_RS23830	COG0640	Transcriptional regulator
GZL_RS23850	COG2205	protein histidine kinase activity
GZL_RS23855	COG0514	ATP-dependent DNA helicase (RecQ)
GZL_RS23880	COG1309	transcriptional regulator
GZL_RS23900	COG1846	Transcriptional regulator
GZL_RS23920	COG1247	-acetyltransferase
GZL_RS23930	COG1349	DNA-binding transcription factor activity
GZL_RS23940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZL_RS23940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZL_RS23965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZL_RS23965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZL_RS23965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZL_RS23980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZL_RS24000	COG3191	aminopeptidase activity
GZL_RS24040	COG2188	Transcriptional regulator
GZL_RS24050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZL_RS24060	COG1970	mechanosensitive ion channel activity
GZL_RS24065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GZL_RS24080	COG3263	regulation of cellular component size
GZL_RS24090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZL_RS24095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZL_RS24105	COG0315	cyclic pyranopterin monophosphate synthase activity
GZL_RS24110	COG0315	cyclic pyranopterin monophosphate synthase activity
GZL_RS24110	COG0521	Mo-molybdopterin cofactor biosynthetic process
GZL_RS24115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZL_RS24155	COG1819	glycosyl
GZL_RS24160	COG0789	Transcriptional regulator
GZL_RS24170	COG2205	protein histidine kinase activity
GZL_RS24175	COG1725	Transcriptional regulator
GZL_RS24185	COG3547	Transposase (IS116 IS110 IS902 family)
GZL_RS24205	COG0708	Exodeoxyribonuclease III
GZL_RS24220	COG2072	flavoprotein involved in K transport
GZL_RS24225	COG2267	carboxylic ester hydrolase activity
GZL_RS24230	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS24240	COG0793	Belongs to the peptidase S41A family
GZL_RS24240	COG4946	Tricorn protease homolog
GZL_RS24300	COG0084	hydrolase, TatD family'
GZL_RS24310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZL_RS24315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GZL_RS24350	COG0488	(ABC) transporter
GZL_RS24380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GZL_RS24385	COG2197	response regulator
GZL_RS24405	COG4106	trans-aconitate 2-methyltransferase activity
GZL_RS24410	COG1309	transcriptional regulator
GZL_RS24420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GZL_RS24425	COG0193	aminoacyl-tRNA hydrolase activity
GZL_RS24430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GZL_RS24435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZL_RS24440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GZL_RS24450	COG4585	Histidine kinase
GZL_RS24480	COG2814	Major facilitator Superfamily
GZL_RS24515	COG2815	serine threonine protein kinase
GZL_RS24515	COG0515	serine threonine protein kinase
GZL_RS24560	COG2814	Major facilitator Superfamily
GZL_RS24565	COG0583	DNA-binding transcription factor activity
GZL_RS24570	COG2124	cytochrome p450
GZL_RS24585	COG0148	phosphopyruvate hydratase activity
GZL_RS24610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GZL_RS24615	COG0577	efflux transmembrane transporter activity
GZL_RS24620	COG0577	efflux transmembrane transporter activity
GZL_RS24620	COG1136	(ABC) transporter
GZL_RS24630	COG0297	glycogen (starch) synthase activity
GZL_RS24635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZL_RS24660	COG0183	Belongs to the thiolase family
GZL_RS24665	COG2755	lipolytic protein G-D-S-L family
GZL_RS24680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZL_RS24700	COG1131	(ABC) transporter
GZL_RS24715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GZL_RS24720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZL_RS24730	COG1228	amidohydrolase
GZL_RS24735	COG1191	sigma factor activity
GZL_RS24740	COG1366	Belongs to the anti-sigma-factor antagonist family
GZL_RS24770	COG3104	oligopeptide transport
GZL_RS24775	COG0745	RESPONSE REGULATOR receiver
GZL_RS24780	COG2205	protein histidine kinase activity
GZL_RS24810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GZL_RS24820	COG1316	TRANSCRIPTIONal
GZL_RS24840	COG1316	TRANSCRIPTIONal
GZL_RS24850	COG1316	TRANSCRIPTIONal
GZL_RS24885	COG0778	Nitroreductase
GZL_RS24885	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GZL_RS24890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZL_RS24925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZL_RS24930	COG2835	tetraacyldisaccharide 4'-kinase activity
GZL_RS24940	COG1482	cell wall glycoprotein biosynthetic process
GZL_RS24950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GZL_RS24990	COG0714	Associated with various cellular activities
GZL_RS25010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GZL_RS25015	COG0745	RESPONSE REGULATOR receiver
GZL_RS25020	COG5002	protein histidine kinase activity
GZL_RS25020	COG5000	phosphorelay sensor kinase activity
GZL_RS25025	COG0823	Involved in the tonB-independent uptake of proteins
GZL_RS25035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZL_RS25040	COG2197	response regulator
GZL_RS25045	COG3214	Protein conserved in bacteria
GZL_RS25055	COG0653	protein targeting
GZL_RS25070	COG0546	phosphoglycolate phosphatase activity
GZL_RS25075	COG2902	Dehydrogenase
GZL_RS25080	COG1134	teichoic acid transport
GZL_RS25080	COG1388	LysM domain
GZL_RS25090	COG1309	transcriptional regulator
GZL_RS25110	COG0463	Glycosyl transferase, family 2
GZL_RS25130	COG2188	Transcriptional regulator
GZL_RS25175	COG0395	ABC-type sugar transport system, permease component
GZL_RS25180	COG1175	transmembrane transport
GZL_RS25185	COG1653	transport
GZL_RS25195	COG0515	serine threonine protein kinase
GZL_RS25200	COG0515	serine threonine protein kinase
GZL_RS25205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GZL_RS25220	COG2884	Cell division ATP-binding protein ftsE
GZL_RS25225	COG2177	Part of the ABC transporter FtsEX involved in
GZL_RS25230	COG0793	Belongs to the peptidase S41A family
GZL_RS25235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZL_RS25255	COG2223	nitrite transmembrane transporter activity
GZL_RS25265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GZL_RS25275	COG3973	AAA domain
GZL_RS25285	COG0776	regulation of translation
GZL_RS25290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZL_RS25295	COG1678	Uncharacterized ACR, COG1678
GZL_RS25305	COG0583	DNA-binding transcription factor activity
GZL_RS25310	COG2814	Major facilitator Superfamily
GZL_RS25320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GZL_RS25330	COG2080	2 iron, 2 sulfur cluster binding
GZL_RS25335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GZL_RS25375	COG1174	glycine betaine transport
GZL_RS25380	COG1125	glycine betaine transport
GZL_RS25380	COG0517	IMP dehydrogenase activity
GZL_RS25385	COG1174	glycine betaine transport
GZL_RS25395	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GZL_RS25400	COG0277	FAD linked oxidase domain protein
GZL_RS25450	COG0222	ribosome binding
GZL_RS25455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZL_RS25490	COG1335	isochorismatase
GZL_RS25500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GZL_RS25510	COG1113	amino acid transport
GZL_RS25535	COG1234	tRNA 3'-trailer cleavage
GZL_RS25540	COG1263	PTS System
GZL_RS25545	COG1263	PTS System
GZL_RS25550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZL_RS25555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GZL_RS25565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZL_RS25595	COG2205	protein histidine kinase activity
GZL_RS25610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZL_RS25620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZL_RS25635	COG1131	(ABC) transporter
GZL_RS25650	COG2733	membrane
GZL_RS25660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZL_RS25670	COG0706	membrane insertase activity
GZL_RS25675	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZL_RS25680	COG4702	Belongs to the UPF0303 family
GZL_RS25685	COG0673	inositol 2-dehydrogenase activity
GZL_RS25695	COG2188	Transcriptional regulator
GZL_RS25700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZL_RS25705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZL_RS25760	COG2318	DinB family
GZL_RS25765	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS25780	COG1126	abc transporter atp-binding protein
GZL_RS25785	COG0765	amino acid transport
GZL_RS25790	COG0765	amino acid transport
GZL_RS25805	COG0154	amidase activity
GZL_RS25825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS25885	COG0438	transferase activity, transferring glycosyl groups
GZL_RS25890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZL_RS25895	COG0438	transferase activity, transferring glycosyl groups
GZL_RS25920	COG0745	RESPONSE REGULATOR receiver
GZL_RS25930	COG3979	chitinase
GZL_RS25940	COG2910	NAD(P)H-binding
GZL_RS25950	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GZL_RS25955	COG4977	sequence-specific DNA binding
GZL_RS25960	COG0589	response to stress
GZL_RS25965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZL_RS25980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GZL_RS26015	COG1960	acyl-CoA dehydrogenase activity
GZL_RS26030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZL_RS26035	COG1309	transcriptional regulator
GZL_RS26040	COG1960	acyl-CoA dehydrogenase activity
GZL_RS26045	COG1946	Acyl-CoA thioesterase
GZL_RS26075	COG1309	transcriptional regulator
GZL_RS26085	COG1131	(ABC) transporter
GZL_RS26090	COG1554	hydrolase, family 65, central catalytic
GZL_RS26105	COG0488	(ABC) transporter
GZL_RS26115	COG1472	Belongs to the glycosyl hydrolase 3 family
GZL_RS26125	COG0673	inositol 2-dehydrogenase activity
GZL_RS26140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GZL_RS26150	COG2608	mercury ion transmembrane transporter activity
GZL_RS26155	COG0586	Pfam SNARE associated Golgi protein
GZL_RS26170	COG0673	inositol 2-dehydrogenase activity
GZL_RS26190	COG2814	Major facilitator Superfamily
GZL_RS26195	COG0673	inositol 2-dehydrogenase activity
GZL_RS26215	COG3718	enzyme involved in inositol metabolism
GZL_RS26220	COG3962	Belongs to the TPP enzyme family
GZL_RS26240	COG1131	(ABC) transporter
GZL_RS26255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GZL_RS26265	COG1077	Cell shape determining protein MreB Mrl
GZL_RS26305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS26315	COG2197	response regulator
GZL_RS26320	COG2226	methyltransferase
GZL_RS26325	COG4585	Histidine kinase
GZL_RS26345	COG0629	single-stranded DNA binding
GZL_RS26370	COG1136	(ABC) transporter
GZL_RS26420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZL_RS26430	COG2186	Transcriptional regulator
GZL_RS26445	COG1486	melibiose metabolic process
GZL_RS26450	COG0395	ABC-type sugar transport system, permease component
GZL_RS26455	COG1175	transmembrane transport
GZL_RS26460	COG1653	transport
GZL_RS26465	COG1846	Transcriptional regulator
GZL_RS26465	COG1940	carbohydrate kinase activity
GZL_RS26475	COG0668	transmembrane transport
GZL_RS26515	COG0583	DNA-binding transcription factor activity
GZL_RS26520	COG4266	Belongs to the allantoicase family
GZL_RS26550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GZL_RS26555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GZL_RS26560	COG1113	amino acid transport
GZL_RS26565	COG1113	amino acid transport
GZL_RS26575	COG1113	amino acid transport
GZL_RS26580	COG0698	ribose 5-phosphate isomerase
GZL_RS26590	COG4552	Acetyltransferase involved in intracellular survival and related
GZL_RS26600	COG0475	glutathione-regulated potassium exporter activity
GZL_RS26625	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZL_RS26630	COG0740	serine-type endopeptidase activity
GZL_RS26635	COG0740	serine-type endopeptidase activity
GZL_RS26640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZL_RS26650	COG0525	valine-tRNA ligase activity
GZL_RS26660	COG0768	penicillin binding
GZL_RS26665	COG0285	dihydrofolate synthase activity
GZL_RS26675	COG0105	UTP biosynthetic process
GZL_RS26680	COG1077	Cell shape determining protein MreB Mrl
GZL_RS26695	COG0768	penicillin binding
GZL_RS26700	COG0772	Belongs to the SEDS family
GZL_RS26725	COG1530	ribonuclease E activity
GZL_RS26730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZL_RS26735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZL_RS26740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZL_RS26750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GZL_RS26760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GZL_RS26775	COG0501	Belongs to the peptidase M48B family
GZL_RS26785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZL_RS26795	COG0799	negative regulation of ribosome biogenesis
GZL_RS26830	COG0495	leucyl-tRNA aminoacylation
GZL_RS26840	COG1307	EDD domain protein, DegV family
GZL_RS26850	COG1234	tRNA 3'-trailer cleavage
GZL_RS26855	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GZL_RS26875	COG0268	Binds directly to 16S ribosomal RNA
GZL_RS26880	COG0481	GTPase activity
GZL_RS26885	COG1022	Amp-dependent synthetase and ligase
GZL_RS26915	COG1420	regulation of RNA biosynthetic process
GZL_RS26920	COG0484	heat shock protein binding
GZL_RS26940	COG0537	adenosine 5'-monophosphoramidase activity
GZL_RS26945	COG1234	tRNA 3'-trailer cleavage
GZL_RS26955	COG4948	Mandelate Racemase Muconate Lactonizing
GZL_RS26970	COG1486	melibiose metabolic process
GZL_RS26985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZL_RS27000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZL_RS27005	COG2723	6-phospho-beta-galactosidase activity
GZL_RS27020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZL_RS27080	COG1381	Involved in DNA repair and RecF pathway recombination
GZL_RS27085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZL_RS27095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZL_RS27100	COG1121	(ABC) transporter
GZL_RS27105	COG3443	Belongs to the bacterial solute-binding protein 9 family
GZL_RS27105	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZL_RS27110	COG0423	glycine-tRNA ligase activity
GZL_RS27120	COG0667	Aldo Keto reductase
GZL_RS27125	COG0477	Major facilitator Superfamily
GZL_RS27150	COG0477	Major facilitator Superfamily
GZL_RS27160	COG0574	Belongs to the PEP-utilizing enzyme family
GZL_RS27160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZL_RS27225	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS27240	COG2175	clavaminate synthase activity
GZL_RS27245	COG0395	ABC-type sugar transport system, permease component
GZL_RS27250	COG1175	transmembrane transport
GZL_RS27255	COG2182	Extracellular solute-binding protein
GZL_RS27265	COG0531	amino acid
GZL_RS27280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZL_RS27280	COG2146	nitrite reductase [NAD(P)H] activity
GZL_RS27285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZL_RS27295	COG2197	response regulator
GZL_RS27325	COG1473	amidohydrolase
GZL_RS27350	COG0667	Aldo Keto reductase
GZL_RS27360	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GZL_RS27380	COG2949	membrane
GZL_RS27390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZL_RS27395	COG0243	molybdopterin cofactor binding
GZL_RS27405	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GZL_RS27420	COG0358	DNA primase activity
GZL_RS27430	COG1070	Carbohydrate kinase
GZL_RS27585	COG0124	histidyl-tRNA synthetase
GZL_RS27650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GZL_RS27670	COG0494	nUDIX hydrolase
GZL_RS27675	COG0494	nUDIX hydrolase
GZL_RS27805	COG0776	regulation of translation
GZL_RS27895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZL_RS27900	COG0588	phosphoglycerate mutase activity
GZL_RS27905	COG1077	Cell shape determining protein MreB Mrl
GZL_RS27940	COG4981	capsule polysaccharide biosynthetic process
GZL_RS27945	COG0500	methyltransferase
GZL_RS27970	COG0477	Major facilitator Superfamily
GZL_RS27975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GZL_RS27985	COG2130	NADP-dependent
GZL_RS27995	COG1764	response to oxidative stress
GZL_RS28000	COG1609	Transcriptional regulator
GZL_RS28005	COG1129	ABC transporter
GZL_RS28010	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZL_RS28015	COG1879	ABC-type sugar transport system periplasmic component
GZL_RS28020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZL_RS28030	COG1309	transcriptional regulator
GZL_RS28055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZL_RS28060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZL_RS28065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZL_RS28070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS28090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZL_RS28095	COG0789	Transcriptional regulator
GZL_RS28100	COG0667	Aldo Keto reductase
GZL_RS28115	COG2197	response regulator
GZL_RS28120	COG4585	Histidine kinase
GZL_RS28135	COG1309	transcriptional regulator
GZL_RS28140	COG0477	Major facilitator Superfamily
GZL_RS28150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GZL_RS28195	COG1358	cellular component organization or biogenesis
GZL_RS28220	COG4948	Mandelate Racemase Muconate Lactonizing
GZL_RS28225	COG2186	Transcriptional regulator
GZL_RS28250	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZL_RS28265	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GZL_RS28280	COG1072	(Pantothenic acid kinase))
GZL_RS28330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZL_RS28380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZL_RS28390	COG2124	cytochrome p450
GZL_RS28395	COG0183	Belongs to the thiolase family
GZL_RS28415	COG3845	ABC transporter
GZL_RS28475	COG1309	transcriptional regulator
GZL_RS28480	COG0438	transferase activity, transferring glycosyl groups
GZL_RS28505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS28525	COG1960	acyl-CoA dehydrogenase activity
GZL_RS28530	COG0183	Belongs to the thiolase family
GZL_RS28535	COG0251	oxidation-reduction process
GZL_RS28545	COG2197	response regulator
GZL_RS28550	COG4585	Histidine kinase
GZL_RS28560	COG1131	(ABC) transporter
GZL_RS28565	COG2030	dehydratase
GZL_RS28585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZL_RS28590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZL_RS28605	COG0800	Aldolase
GZL_RS28610	COG3022	response to hydroperoxide
GZL_RS28615	COG0557	exoribonuclease II activity
GZL_RS28625	COG0789	Transcriptional regulator
GZL_RS28665	COG1316	TRANSCRIPTIONal
GZL_RS28670	COG0438	transferase activity, transferring glycosyl groups
GZL_RS28695	COG0438	transferase activity, transferring glycosyl groups
GZL_RS28705	COG0438	transferase activity, transferring glycosyl groups
GZL_RS28730	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS28735	COG2814	Major facilitator Superfamily
GZL_RS28740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZL_RS28770	COG5398	heme oxygenase
GZL_RS28790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZL_RS28795	COG2186	Transcriptional regulator
GZL_RS28805	COG1175	transmembrane transport
GZL_RS28825	COG1994	Peptidase M50
GZL_RS28845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GZL_RS28850	COG0477	Major facilitator Superfamily
GZL_RS28855	COG1309	transcriptional regulator
GZL_RS28875	COG2814	Major facilitator Superfamily
GZL_RS28880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZL_RS28880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GZL_RS28885	COG2132	Multicopper oxidase
GZL_RS28900	COG0174	glutamine synthetase
GZL_RS28905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GZL_RS28915	COG1609	Transcriptional regulator
GZL_RS28920	COG0366	Alpha amylase catalytic
GZL_RS28925	COG2182	Extracellular solute-binding protein
GZL_RS28930	COG1175	transmembrane transport
GZL_RS28935	COG3833	ABC-type maltose transport systems, permease component
GZL_RS28940	COG0366	Alpha amylase catalytic
GZL_RS29030	COG0745	RESPONSE REGULATOR receiver
GZL_RS29045	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS29090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GZL_RS29095	COG0321	lipoyl(octanoyl) transferase activity
GZL_RS29135	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GZL_RS29145	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZL_RS29150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZL_RS29155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GZL_RS29170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GZL_RS29170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GZL_RS29175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GZL_RS29210	COG4585	Histidine kinase
GZL_RS29215	COG2197	response regulator
GZL_RS29220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZL_RS29225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GZL_RS29230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZL_RS29235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GZL_RS29250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZL_RS29260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GZL_RS29265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZL_RS29275	COG1376	ErfK ybiS ycfS ynhG family protein
GZL_RS29285	COG1845	cytochrome c oxidase, subunit III
GZL_RS29290	COG2010	Cytochrome c
GZL_RS29295	COG0723	plastoquinol--plastocyanin reductase activity
GZL_RS29300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZL_RS29305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZL_RS29310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZL_RS29355	COG0438	transferase activity, transferring glycosyl groups
GZL_RS29375	COG0003	Pfam Anion-transporting ATPase
GZL_RS29385	COG1940	carbohydrate kinase activity
GZL_RS29415	COG2197	response regulator
GZL_RS29420	COG0205	6-phosphofructokinase activity
GZL_RS29425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZL_RS29435	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GZL_RS29440	COG0243	molybdopterin cofactor binding
GZL_RS29445	COG2193	ferroxidase activity
GZL_RS29450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GZL_RS29455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GZL_RS29460	COG0515	serine threonine protein kinase
GZL_RS29460	COG2815	serine threonine protein kinase
GZL_RS29470	COG2022	thiamine diphosphate biosynthetic process
GZL_RS29480	COG2022	thiamine diphosphate biosynthetic process
GZL_RS29480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZL_RS29495	COG0352	thiamine-phosphate diphosphorylase activity
GZL_RS29520	COG1309	transcriptional regulator
GZL_RS29530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GZL_RS29540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZL_RS29560	COG0714	Associated with various cellular activities
GZL_RS29570	COG0275	rRNA processing
GZL_RS29580	COG0768	penicillin binding
GZL_RS29585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GZL_RS29595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZL_RS29600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZL_RS29610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZL_RS29615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GZL_RS29635	COG1799	cell septum assembly
GZL_RS29650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GZL_RS29660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZL_RS29705	COG0587	DNA-directed DNA polymerase activity
GZL_RS29710	COG1432	Conserved Protein
GZL_RS29730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZL_RS29745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GZL_RS29750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZL_RS29755	COG0131	Imidazoleglycerol-phosphate dehydratase
GZL_RS29765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GZL_RS29770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GZL_RS29775	COG0251	oxidation-reduction process
GZL_RS29780	COG0107	imidazoleglycerol-phosphate synthase activity
GZL_RS29785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZL_RS29790	COG1053	succinate dehydrogenase
GZL_RS29800	COG0583	DNA-binding transcription factor activity
GZL_RS29815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GZL_RS29840	COG0134	indole-3-glycerol-phosphate synthase activity
GZL_RS29845	COG0133	tryptophan synthase activity
GZL_RS29850	COG0159	tryptophan synthase activity
GZL_RS29860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GZL_RS29875	COG0067	glutamate synthase
GZL_RS29875	COG0070	glutamate synthase
GZL_RS29875	COG0069	glutamate synthase activity
GZL_RS29890	COG0640	Transcriptional regulator
GZL_RS29905	COG3467	pyridoxamine 5'-phosphate
GZL_RS29935	COG2197	response regulator
GZL_RS29945	COG1470	cell adhesion involved in biofilm formation
GZL_RS29945	COG0366	Alpha amylase catalytic
GZL_RS30005	COG0737	Belongs to the 5'-nucleotidase family
GZL_RS30040	COG0411	ABC transporter
GZL_RS30090	COG1643	Atp-dependent helicase
GZL_RS30095	COG1073	alpha beta
GZL_RS30095	COG2226	methyltransferase
GZL_RS30120	COG0237	dephospho-CoA kinase activity
GZL_RS30145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZL_RS30215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GZL_RS30220	COG0584	glycerophosphoryl diester phosphodiesterase
GZL_RS30225	COG0556	nucleotide-excision repair
GZL_RS30260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZL_RS30270	COG1609	Transcriptional regulator
GZL_RS30275	COG1063	alcohol dehydrogenase
GZL_RS30280	COG2814	Major facilitator Superfamily
GZL_RS30305	COG0322	excinuclease ABC activity
GZL_RS30310	COG1660	Displays ATPase and GTPase activities
GZL_RS30315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZL_RS30320	COG1481	regulation of sporulation
GZL_RS30325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZL_RS30330	COG0126	phosphoglycerate kinase activity
GZL_RS30335	COG0149	triose-phosphate isomerase activity
GZL_RS30340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZL_RS30355	COG0166	Belongs to the GPI family
GZL_RS30360	COG0363	glucosamine-6-phosphate deaminase activity
GZL_RS30375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GZL_RS30380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZL_RS30385	COG0109	protoheme IX farnesyltransferase activity
GZL_RS30400	COG1612	heme a metabolic process
GZL_RS30410	COG1131	(ABC) transporter
GZL_RS30425	COG0719	Fe-S assembly protein
GZL_RS30435	COG0396	ATPase activity
GZL_RS30440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZL_RS30445	COG0822	iron-sulfur transferase activity
GZL_RS30450	COG2151	metal-sulfur cluster biosynthetic enzyme
GZL_RS30460	COG3226	Transcriptional regulator
GZL_RS30465	COG2171	N-acyltransferase activity
GZL_RS30485	COG2226	methyltransferase
GZL_RS30495	COG2261	transglycosylase associated protein
GZL_RS30500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZL_RS30505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZL_RS30525	COG1414	Transcriptional regulator
GZL_RS30555	COG1902	pentaerythritol trinitrate reductase activity
GZL_RS30565	COG1917	Cupin 2, conserved barrel domain protein
GZL_RS30570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GZL_RS30575	COG0456	acetyltransferase
GZL_RS30605	COG1797	cobyrinic acid a,c-diamide synthase activity
GZL_RS30620	COG1492	cobalamin metabolic process
GZL_RS30625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GZL_RS30640	COG1653	transport
GZL_RS30660	COG0235	Class ii aldolase
GZL_RS30680	COG0488	(ABC) transporter
GZL_RS30690	COG1024	Enoyl-CoA hydratase
GZL_RS30695	COG1302	Protein conserved in bacteria
GZL_RS30725	COG3387	PFAM Glycoside hydrolase 15-related
GZL_RS30755	COG0300	oxidoreductase activity
GZL_RS30810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZL_RS30815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GZL_RS30830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZL_RS30845	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS30850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZL_RS30855	COG2186	Transcriptional regulator
GZL_RS30875	COG0560	Phosphoserine phosphatase
GZL_RS30875	COG3830	Belongs to the UPF0237 family
GZL_RS30880	COG0842	Transport permease protein
GZL_RS30880	COG1716	ATPase activity
GZL_RS30880	COG1131	(ABC) transporter
GZL_RS30885	COG3953	SLT domain
GZL_RS30885	COG5280	Phage tail tape measure protein TP901
GZL_RS30895	COG4585	Histidine kinase
GZL_RS30900	COG2197	response regulator
GZL_RS30920	COG1119	ATPase activity
GZL_RS30945	COG1881	PFAM PEBP family protein
GZL_RS30955	COG2094	Belongs to the DNA glycosylase MPG family
GZL_RS30995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GZL_RS31010	COG0647	UMP catabolic process
GZL_RS31025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS31030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS31035	COG1120	ATPase activity
GZL_RS31055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZL_RS31065	COG0497	DNA recombination
GZL_RS31090	COG3387	PFAM Glycoside hydrolase 15-related
GZL_RS31095	COG0504	CTP synthase activity
GZL_RS31100	COG0494	nUDIX hydrolase
GZL_RS31110	COG0686	Belongs to the AlaDH PNT family
GZL_RS31125	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GZL_RS31130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GZL_RS31135	COG1187	pseudouridine synthase activity
GZL_RS31145	COG3541	Predicted nucleotidyltransferase
GZL_RS31165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GZL_RS31175	COG1160	GTP binding
GZL_RS31190	COG3583	domain protein
GZL_RS31195	COG0438	transferase activity, transferring glycosyl groups
GZL_RS31205	COG0789	Transcriptional regulator
GZL_RS31210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZL_RS31220	COG0671	phosphoesterase, PA-phosphatase related
GZL_RS31230	COG0477	Major facilitator Superfamily
GZL_RS31235	COG1960	acyl-CoA dehydrogenase activity
GZL_RS31240	COG1799	cell septum assembly
GZL_RS31245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZL_RS31255	COG0765	amino acid transport
GZL_RS31270	COG1126	abc transporter atp-binding protein
GZL_RS31275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZL_RS31280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS31285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS31300	COG0330	HflC and HflK could
GZL_RS31320	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS31330	COG0587	DNA-directed DNA polymerase activity
GZL_RS31335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZL_RS31345	COG0531	amino acid
GZL_RS31365	COG2226	methyltransferase
GZL_RS31375	COG0367	asparagine synthase
GZL_RS31380	COG1725	Transcriptional regulator
GZL_RS31400	COG3619	membrane
GZL_RS31425	COG0477	Major facilitator Superfamily
GZL_RS31425	COG2814	Major facilitator Superfamily
GZL_RS31430	COG2188	Transcriptional regulator
GZL_RS31435	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GZL_RS31440	COG1309	transcriptional regulator
GZL_RS31455	COG4413	Urea transporter
GZL_RS31465	COG1960	acyl-CoA dehydrogenase activity
GZL_RS31515	COG0477	Major facilitator Superfamily
GZL_RS31520	COG3876	Protein conserved in bacteria
GZL_RS31540	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS31545	COG1309	transcriptional regulator
GZL_RS31570	COG2149	membrane
GZL_RS31575	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GZL_RS31605	COG0745	RESPONSE REGULATOR receiver
GZL_RS31615	COG2124	cytochrome p450
GZL_RS31620	COG0488	(ABC) transporter
GZL_RS31635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZL_RS31645	COG3425	synthase
GZL_RS31655	COG1024	Enoyl-CoA hydratase
GZL_RS31860	COG1674	ftsk spoiiie
GZL_RS31925	COG3328	transposase activity
GZL_RS32005	COG2255	four-way junction helicase activity
GZL_RS32055	COG4974	Belongs to the 'phage' integrase family
GZL_RS32065	COG1388	LysM domain
GZL_RS32065	COG0791	NLP P60 protein
GZL_RS32125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZL_RS32155	COG0667	Aldo Keto reductase
GZL_RS32160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS32170	COG0598	Magnesium transport protein CorA
GZL_RS32190	COG0215	cysteine-tRNA ligase activity
GZL_RS32200	COG4948	Mandelate Racemase Muconate Lactonizing
GZL_RS32205	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS32215	COG1129	ABC transporter
GZL_RS32220	COG4211	Belongs to the binding-protein-dependent transport system permease family
GZL_RS32230	COG3618	amidohydrolase
GZL_RS32235	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS32240	COG2186	Transcriptional regulator
GZL_RS32245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS32250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GZL_RS32255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZL_RS32260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZL_RS32265	COG1414	Transcriptional regulator
GZL_RS32270	COG0646	methionine synthase
GZL_RS32270	COG1410	methionine synthase
GZL_RS32275	COG0546	phosphoglycolate phosphatase activity
GZL_RS32280	COG0747	negative chemotaxis
GZL_RS32290	COG2197	response regulator
GZL_RS32300	COG1994	Peptidase M50
GZL_RS32300	COG0517	IMP dehydrogenase activity
GZL_RS32320	COG1222	aaa ATPase
GZL_RS32325	COG4122	O-methyltransferase activity
GZL_RS32335	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GZL_RS32340	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GZL_RS32345	COG1609	Transcriptional regulator
GZL_RS32355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GZL_RS32360	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZL_RS32390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZL_RS32395	COG0805	protein transport
GZL_RS32405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS32430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZL_RS32435	COG0517	IMP dehydrogenase activity
GZL_RS32435	COG4175	Glycine betaine
GZL_RS32455	COG2186	Transcriptional regulator
GZL_RS32495	COG2233	PERMEase
GZL_RS32510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GZL_RS32515	COG1113	amino acid transport
GZL_RS32520	COG2186	Transcriptional regulator
GZL_RS32530	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS32535	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS32565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZL_RS32575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZL_RS32580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZL_RS32585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GZL_RS32590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZL_RS32595	COG5002	protein histidine kinase activity
GZL_RS32600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZL_RS32605	COG0072	phenylalanine-tRNA ligase activity
GZL_RS32605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZL_RS32615	COG0494	nUDIX hydrolase
GZL_RS32635	COG3629	intracellular signal transduction
GZL_RS32635	COG3903	Transcriptional regulator
GZL_RS32640	COG3903	Transcriptional regulator
GZL_RS32640	COG3629	intracellular signal transduction
GZL_RS32660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GZL_RS32665	COG0583	DNA-binding transcription factor activity
GZL_RS32675	COG1846	Transcriptional regulator
GZL_RS32680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GZL_RS32685	COG0163	prenyltransferase activity
GZL_RS32700	COG1649	PFAM Uncharacterised BCR, COG1649
GZL_RS32710	COG0697	spore germination
GZL_RS32720	COG0456	acetyltransferase
GZL_RS32730	COG4106	trans-aconitate 2-methyltransferase activity
GZL_RS32745	COG1309	transcriptional regulator
GZL_RS32760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GZL_RS32765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GZL_RS32770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GZL_RS32775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZL_RS32780	COG1438	arginine binding
GZL_RS32800	COG0137	argininosuccinate synthase activity
GZL_RS32805	COG0165	Argininosuccinate lyase
GZL_RS32815	COG0477	Major facilitator Superfamily
GZL_RS32830	COG0584	glycerophosphoryl diester phosphodiesterase
GZL_RS32855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZL_RS32860	COG2011	ABC-type metal ion transport system permease component
GZL_RS32865	COG1464	Belongs to the NlpA lipoprotein family
GZL_RS32880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GZL_RS32885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZL_RS32885	COG1648	precorrin-2 dehydrogenase activity
GZL_RS32935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZL_RS32985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZL_RS33000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZL_RS33030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZL_RS33035	COG1560	Kdo2-lipid A biosynthetic process
GZL_RS33040	COG0438	transferase activity, transferring glycosyl groups
GZL_RS33050	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GZL_RS33055	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GZL_RS33060	COG0217	transcriptional regulatory protein
GZL_RS33065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GZL_RS33070	COG0632	four-way junction helicase activity
GZL_RS33075	COG2255	four-way junction helicase activity
GZL_RS33085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZL_RS33090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZL_RS33095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZL_RS33100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZL_RS33120	COG1196	nuclear chromosome segregation
GZL_RS33125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZL_RS33135	COG0124	histidyl-tRNA synthetase
GZL_RS33155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZL_RS33170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZL_RS33175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GZL_RS33185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZL_RS33190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZL_RS33195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZL_RS33200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GZL_RS33205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GZL_RS33215	COG0006	proline dipeptidase activity
GZL_RS33220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZL_RS33225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZL_RS33235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GZL_RS33240	COG0540	Belongs to the ATCase OTCase family
GZL_RS33245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZL_RS33255	COG0505	Belongs to the CarA family
GZL_RS33260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZL_RS33265	COG0167	dihydroorotate dehydrogenase activity
GZL_RS33270	COG0284	orotidine-5'-phosphate decarboxylase activity
GZL_RS33295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZL_RS33310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZL_RS33320	COG2838	Isocitrate dehydrogenase
GZL_RS33325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZL_RS33330	COG2390	Transcriptional regulator
GZL_RS33350	COG0531	amino acid
GZL_RS33370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZL_RS33395	COG2233	PERMEase
GZL_RS33405	COG0738	Major facilitator superfamily
GZL_RS33410	COG1846	Transcriptional regulator
GZL_RS33410	COG1940	carbohydrate kinase activity
GZL_RS33415	COG1090	epimerase
GZL_RS33430	COG3201	nicotinamide mononucleotide transporter
GZL_RS33435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZL_RS33435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZL_RS33440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GZL_RS33445	COG0140	phosphoribosyl-ATP diphosphatase activity
GZL_RS33450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GZL_RS33510	COG0326	Molecular chaperone. Has ATPase activity
GZL_RS33530	COG0667	Aldo Keto reductase
GZL_RS33545	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS33580	COG0475	glutathione-regulated potassium exporter activity
GZL_RS33585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZL_RS33610	COG3251	PFAM MbtH domain protein
GZL_RS33625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZL_RS33635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GZL_RS33645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZL_RS33660	COG0584	glycerophosphoryl diester phosphodiesterase
GZL_RS33705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GZL_RS33710	COG2318	DinB family
GZL_RS33720	COG0477	Major facilitator Superfamily
GZL_RS33755	COG0445	tRNA wobble uridine modification
GZL_RS33760	COG4585	Histidine kinase
GZL_RS33765	COG2197	response regulator
GZL_RS33775	COG2223	nitrite transmembrane transporter activity
GZL_RS33780	COG1940	carbohydrate kinase activity
GZL_RS33825	COG1349	DNA-binding transcription factor activity
GZL_RS33835	COG0464	growth
GZL_RS33855	COG0633	Ferredoxin
GZL_RS33855	COG3217	Mosc domain protein beta barrel domain protein
GZL_RS33870	COG0463	Glycosyl transferase, family 2
GZL_RS33875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GZL_RS33885	COG2816	NAD+ diphosphatase activity
GZL_RS33920	COG1793	dna ligase
GZL_RS33930	COG0395	ABC-type sugar transport system, permease component
GZL_RS33955	COG0583	DNA-binding transcription factor activity
GZL_RS33970	COG1012	belongs to the aldehyde dehydrogenase family
GZL_RS33990	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GZL_RS33990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZL_RS33990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZL_RS33995	COG1461	Dihydroxyacetone kinase
GZL_RS34000	COG2376	Dihydroxyacetone kinase
GZL_RS34010	COG0604	alcohol dehydrogenase
GZL_RS34040	COG2267	carboxylic ester hydrolase activity
GZL_RS34050	COG0456	acetyltransferase
GZL_RS34070	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GZL_RS34080	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GZL_RS34095	COG2226	methyltransferase
GZL_RS34115	COG1960	acyl-CoA dehydrogenase activity
GZL_RS34125	COG0515	serine threonine protein kinase
GZL_RS34140	COG2070	2-Nitropropane dioxygenase
GZL_RS34160	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS34190	COG1024	Enoyl-CoA hydratase
GZL_RS34265	COG0438	transferase activity, transferring glycosyl groups
GZL_RS34280	COG1984	allophanate hydrolase subunit 2
GZL_RS34285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GZL_RS34290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GZL_RS34310	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GZL_RS34355	COG0596	Alpha beta hydrolase
GZL_RS34365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZL_RS34370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZL_RS34380	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GZL_RS34390	COG1309	transcriptional regulator
GZL_RS34395	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS34405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZL_RS34415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZL_RS34445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GZL_RS34470	COG1716	ATPase activity
GZL_RS34490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZL_RS34500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GZL_RS34500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GZL_RS34535	COG1695	Transcriptional regulator
GZL_RS34575	COG0492	ferredoxin-NADP+ reductase activity
GZL_RS34595	COG0697	spore germination
GZL_RS34600	COG0583	DNA-binding transcription factor activity
GZL_RS34605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GZL_RS34605	COG0825	malonyl-CoA metabolic process
GZL_RS34610	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS34665	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS34675	COG0667	Aldo Keto reductase
GZL_RS34690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZL_RS34695	COG4106	trans-aconitate 2-methyltransferase activity
GZL_RS34700	COG2843	Capsule synthesis protein
GZL_RS34710	COG0640	Transcriptional regulator
GZL_RS34725	COG0477	Major facilitator Superfamily
GZL_RS34745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS34750	COG1120	ATPase activity
GZL_RS34755	COG2608	mercury ion transmembrane transporter activity
GZL_RS34760	COG2814	Major facilitator Superfamily
GZL_RS34765	COG0367	asparagine synthase
GZL_RS34845	COG0667	Aldo Keto reductase
GZL_RS34850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZL_RS34880	COG1132	(ABC) transporter
GZL_RS34940	COG1388	LysM domain
GZL_RS34940	COG3942	CHAP domain
GZL_RS35115	COG1278	Cold shock
GZL_RS35175	COG3422	double-strand break repair
GZL_RS35180	COG0629	single-stranded DNA binding
GZL_RS35235	COG0386	Belongs to the glutathione peroxidase family
GZL_RS35250	COG2318	DinB family
GZL_RS35265	COG0154	amidase activity
GZL_RS35290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZL_RS35295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZL_RS35310	COG2226	methyltransferase
GZL_RS35325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZL_RS35385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZL_RS35400	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GZL_RS35435	COG2814	Major facilitator Superfamily
GZL_RS35450	COG3835	regulator
GZL_RS35455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GZL_RS35460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GZL_RS35460	COG2080	2 iron, 2 sulfur cluster binding
GZL_RS35475	COG3585	molybdate ion transport
GZL_RS35510	COG0477	Major facilitator Superfamily
GZL_RS35530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZL_RS35530	COG1024	Enoyl-CoA hydratase
GZL_RS35535	COG0745	RESPONSE REGULATOR receiver
GZL_RS35560	COG1687	branched-chain amino acid
GZL_RS35570	COG1522	sequence-specific DNA binding
GZL_RS35575	COG4977	sequence-specific DNA binding
GZL_RS35610	COG2318	DinB family
GZL_RS35635	COG1063	alcohol dehydrogenase
GZL_RS35640	COG0156	8-amino-7-oxononanoate synthase activity
GZL_RS35645	COG0583	DNA-binding transcription factor activity
GZL_RS35650	COG1796	DNA polymerase
GZL_RS35650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZL_RS35665	COG2274	protein secretion by the type I secretion system
GZL_RS35715	COG2226	methyltransferase
GZL_RS35725	COG0596	Alpha beta hydrolase
GZL_RS35730	COG1335	isochorismatase
GZL_RS35760	COG2309	aminopeptidase activity
GZL_RS35795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZL_RS35845	COG0076	glutamate decarboxylase activity
GZL_RS35865	COG0772	Belongs to the SEDS family
GZL_RS35875	COG0531	amino acid
GZL_RS35905	COG0494	nUDIX hydrolase
GZL_RS35925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZL_RS35935	COG4585	Histidine kinase
GZL_RS35940	COG2197	response regulator
GZL_RS36000	COG0529	Catalyzes the synthesis of activated sulfate
GZL_RS36030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZL_RS36040	COG0531	amino acid
GZL_RS36045	COG0640	Transcriptional regulator
GZL_RS36065	COG2186	Transcriptional regulator
GZL_RS36080	COG0789	Transcriptional regulator
GZL_RS36095	COG0076	glutamate decarboxylase activity
GZL_RS36105	COG2267	carboxylic ester hydrolase activity
GZL_RS36115	COG4565	transcriptional regulatory protein
GZL_RS36120	COG3290	protein histidine kinase activity
GZL_RS36130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZL_RS36220	COG0542	response to heat
GZL_RS36225	COG0477	Major facilitator Superfamily
GZL_RS36235	COG2124	cytochrome p450
GZL_RS36250	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS36275	COG0300	oxidoreductase activity
GZL_RS36310	COG3387	PFAM Glycoside hydrolase 15-related
GZL_RS36320	COG3979	chitinase
GZL_RS36335	COG1309	transcriptional regulator
GZL_RS36355	COG0583	DNA-binding transcription factor activity
GZL_RS36395	COG1695	Transcriptional regulator
GZL_RS36405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZL_RS36410	COG1902	pentaerythritol trinitrate reductase activity
GZL_RS36430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZL_RS36455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZL_RS36480	COG0596	Alpha beta hydrolase
GZL_RS36505	COG1595	DNA-templated transcription, initiation
GZL_RS36525	COG2391	methyltransferase activity
GZL_RS36530	COG0515	serine threonine protein kinase
GZL_RS36530	COG2815	serine threonine protein kinase
GZL_RS36590	COG0583	DNA-binding transcription factor activity
GZL_RS36605	COG0590	tRNA wobble adenosine to inosine editing
GZL_RS36610	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZL_RS36620	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS36665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZL_RS36675	COG0697	spore germination
GZL_RS36690	COG1733	regulation of RNA biosynthetic process
GZL_RS36695	COG0702	epimerase
GZL_RS36745	COG1819	glycosyl
GZL_RS36760	COG0477	Major facilitator Superfamily
GZL_RS36775	COG1063	alcohol dehydrogenase
GZL_RS36780	COG0657	acetylesterase activity
GZL_RS36795	COG3903	Transcriptional regulator
GZL_RS36795	COG2197	response regulator
GZL_RS36800	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GZL_RS36830	COG4585	Histidine kinase
GZL_RS36835	COG2197	response regulator
GZL_RS36850	COG2192	nodulation
GZL_RS36855	COG2890	protein-(glutamine-N5) methyltransferase activity
GZL_RS36870	COG3186	Phenylalanine-4-hydroxylase
GZL_RS36895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZL_RS36900	COG4221	oxidoreductase activity
GZL_RS36905	COG0583	DNA-binding transcription factor activity
GZL_RS36940	COG0456	acetyltransferase
GZL_RS36960	COG0644	oxidoreductase
GZL_RS36965	COG3655	Transcriptional regulator
GZL_RS36990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GZL_RS37010	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS37020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GZL_RS37085	COG3903	Transcriptional regulator
GZL_RS37085	COG3629	intracellular signal transduction
GZL_RS37100	COG1968	undecaprenyl-diphosphatase activity
GZL_RS37115	COG0739	heme binding
GZL_RS37135	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS37155	COG0456	acetyltransferase
GZL_RS37155	COG1846	Transcriptional regulator
GZL_RS37170	COG0154	amidase activity
GZL_RS37215	COG1024	Enoyl-CoA hydratase
GZL_RS37250	COG3800	Transcriptional regulator
GZL_RS37250	COG1396	sequence-specific DNA binding
GZL_RS37260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GZL_RS37315	COG0459	protein refolding
GZL_RS37340	COG1278	Cold shock
GZL_RS37345	COG0513	Belongs to the DEAD box helicase family
GZL_RS37390	COG3321	synthase
GZL_RS37390	COG0604	alcohol dehydrogenase
GZL_RS37390	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS37405	COG2409	Drug exporters of the RND superfamily
GZL_RS37425	COG1595	DNA-templated transcription, initiation
GZL_RS37450	COG2226	methyltransferase
GZL_RS37465	COG0640	Transcriptional regulator
GZL_RS37470	COG2059	Chromate
GZL_RS37490	COG2205	protein histidine kinase activity
GZL_RS37495	COG0745	RESPONSE REGULATOR receiver
GZL_RS37545	COG2267	carboxylic ester hydrolase activity
GZL_RS37595	COG0583	DNA-binding transcription factor activity
GZL_RS37620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZL_RS37625	COG1113	amino acid transport
GZL_RS37640	COG0583	DNA-binding transcription factor activity
GZL_RS37645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GZL_RS37645	COG2070	2-Nitropropane dioxygenase
GZL_RS37655	COG0367	asparagine synthase
GZL_RS37660	COG0300	oxidoreductase activity
GZL_RS37660	COG3321	synthase
GZL_RS37660	COG4221	oxidoreductase activity
GZL_RS37660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZL_RS37670	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS37710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZL_RS37715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS37720	COG1120	ATPase activity
GZL_RS37730	COG3903	Transcriptional regulator
GZL_RS37730	COG3629	intracellular signal transduction
GZL_RS37735	COG3959	Transketolase, thiamine diphosphate binding domain
GZL_RS37740	COG0301	tRNA thio-modification
GZL_RS37750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GZL_RS37760	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS37785	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS37800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZL_RS37855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZL_RS37860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZL_RS37905	COG0745	RESPONSE REGULATOR receiver
GZL_RS37930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GZL_RS37945	COG1215	transferase activity, transferring glycosyl groups
GZL_RS37955	COG4310	Domain of unknown function (DUF2172)
GZL_RS37970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GZL_RS38005	COG0367	asparagine synthase
GZL_RS38025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GZL_RS38035	COG3251	PFAM MbtH domain protein
GZL_RS38065	COG0285	dihydrofolate synthase activity
GZL_RS38145	COG1136	(ABC) transporter
GZL_RS38145	COG0577	efflux transmembrane transporter activity
GZL_RS38165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZL_RS38195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GZL_RS38215	COG1278	Cold shock
GZL_RS38220	COG1196	nuclear chromosome segregation
GZL_RS38220	COG0741	lytic transglycosylase activity
GZL_RS38220	COG0739	heme binding
GZL_RS38240	COG2226	methyltransferase
GZL_RS38245	COG0513	Belongs to the DEAD box helicase family
GZL_RS38255	COG0805	protein transport
GZL_RS38340	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS38375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZL_RS38405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GZL_RS38430	COG1794	racemase activity, acting on amino acids and derivatives
GZL_RS38465	COG0181	hydroxymethylbilane synthase activity
GZL_RS38470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZL_RS38500	COG0515	serine threonine protein kinase
GZL_RS38505	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GZL_RS38510	COG0517	IMP dehydrogenase activity
GZL_RS38510	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GZL_RS38525	COG2197	response regulator
GZL_RS38530	COG4585	Histidine kinase
GZL_RS38550	COG0789	Transcriptional regulator
GZL_RS38565	COG1819	glycosyl
GZL_RS38570	COG0789	Transcriptional regulator
GZL_RS38585	COG0657	acetylesterase activity
GZL_RS38590	COG0667	Aldo Keto reductase
GZL_RS38610	COG1476	TRANSCRIPTIONal
GZL_RS38615	COG0640	Transcriptional regulator
GZL_RS38625	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS38655	COG2205	protein histidine kinase activity
GZL_RS38710	COG0640	Transcriptional regulator
GZL_RS38750	COG2824	Alkylphosphonate utilization operon protein PhnA
GZL_RS38770	COG2132	Multicopper oxidase
GZL_RS38790	COG2124	cytochrome p450
GZL_RS38840	COG4221	oxidoreductase activity
GZL_RS38860	COG2226	methyltransferase
GZL_RS38880	COG3387	PFAM Glycoside hydrolase 15-related
GZL_RS38900	COG2267	carboxylic ester hydrolase activity
GZL_RS38905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZL_RS38910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS38920	COG0542	response to heat
GZL_RS38930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZL_RS38940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GZL_RS38965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZL_RS38965	COG0515	serine threonine protein kinase
GZL_RS38970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GZL_RS38975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GZL_RS38980	COG2080	2 iron, 2 sulfur cluster binding
GZL_RS39070	COG1960	acyl-CoA dehydrogenase activity
GZL_RS39075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS39110	COG0154	amidase activity
GZL_RS39115	COG3226	Transcriptional regulator
GZL_RS39145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZL_RS39160	COG1017	nitric oxide dioxygenase activity
GZL_RS39160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZL_RS39165	COG1959	2 iron, 2 sulfur cluster binding
GZL_RS39175	COG0745	RESPONSE REGULATOR receiver
GZL_RS39180	COG0701	Predicted permease
GZL_RS39235	COG1819	glycosyl
GZL_RS39240	COG1191	sigma factor activity
GZL_RS39260	COG2197	response regulator
GZL_RS39275	COG1021	2,3-dihydroxybenzoate-AMP ligase
GZL_RS39290	COG2223	nitrite transmembrane transporter activity
GZL_RS39295	COG2207	Transcriptional regulator
GZL_RS39360	COG0583	DNA-binding transcription factor activity
GZL_RS39375	COG1595	DNA-templated transcription, initiation
GZL_RS39380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZL_RS39400	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS39425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZL_RS39480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZL_RS39490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS39495	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS39500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS39535	COG0583	DNA-binding transcription factor activity
GZL_RS39595	COG2267	carboxylic ester hydrolase activity
GZL_RS39600	COG3226	Transcriptional regulator
GZL_RS39615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZL_RS39645	COG3340	Belongs to the peptidase S51 family
GZL_RS39665	COG1254	Belongs to the acylphosphatase family
GZL_RS39680	COG0697	spore germination
GZL_RS39700	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GZL_RS39705	COG1461	Dihydroxyacetone kinase
GZL_RS39730	COG0596	Alpha beta hydrolase
GZL_RS39735	COG2124	cytochrome p450
GZL_RS39750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GZL_RS39755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZL_RS39790	COG0326	Molecular chaperone. Has ATPase activity
GZL_RS39795	COG2318	DinB family
GZL_RS39800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS39805	COG0488	(ABC) transporter
GZL_RS39850	COG1024	Enoyl-CoA hydratase
GZL_RS39855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GZL_RS39865	COG2272	Belongs to the type-B carboxylesterase lipase family
GZL_RS39875	COG2197	response regulator
GZL_RS39890	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS39905	COG4249	Peptidase C14 caspase catalytic subunit p20
GZL_RS39905	COG2319	Wd-40 repeat
GZL_RS39975	COG3485	protocatechuate 3,4-dioxygenase
GZL_RS39980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZL_RS39995	COG0318	PFAM AMP-dependent synthetase and ligase
GZL_RS40005	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS40065	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZL_RS40070	COG1309	transcriptional regulator
GZL_RS40135	COG1404	Belongs to the peptidase S8 family
GZL_RS40180	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GZL_RS40190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GZL_RS40210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZL_RS40255	COG1335	isochorismatase
GZL_RS40260	COG0477	Major facilitator Superfamily
GZL_RS40290	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZL_RS40305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS40365	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GZL_RS40400	COG1846	Transcriptional regulator
GZL_RS40420	COG1846	Transcriptional regulator
GZL_RS40450	COG0745	RESPONSE REGULATOR receiver
GZL_RS40475	COG3973	AAA domain
GZL_RS40495	COG1252	NADH dehydrogenase
GZL_RS40500	COG1595	DNA-templated transcription, initiation
GZL_RS40505	COG3896	Chloramphenicol phosphotransferase-like protein
GZL_RS40530	COG1960	acyl-CoA dehydrogenase activity
GZL_RS40555	COG0477	Major facilitator Superfamily
GZL_RS40560	COG1280	lysine exporter protein (LysE YggA)
GZL_RS40565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZL_RS40575	COG1335	isochorismatase
GZL_RS40590	COG0586	Pfam SNARE associated Golgi protein
GZL_RS40600	COG2201	protein-glutamate methylesterase activity
GZL_RS40605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GZL_RS40695	COG2409	Drug exporters of the RND superfamily
GZL_RS40705	COG0640	Transcriptional regulator
GZL_RS40710	COG0346	lactoylglutathione lyase activity
GZL_RS40720	COG0477	Major facilitator Superfamily
GZL_RS40735	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS40745	COG0142	geranyltranstransferase activity
GZL_RS40750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZL_RS40780	COG2135	peptidase activity
GZL_RS40785	COG0154	amidase activity
GZL_RS40840	COG2124	cytochrome p450
GZL_RS40850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS40855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS40865	COG2815	serine threonine protein kinase
GZL_RS40865	COG0515	serine threonine protein kinase
GZL_RS40875	COG0477	Major facilitator Superfamily
GZL_RS40950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZL_RS40965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS40970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZL_RS40975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZL_RS40990	COG2197	response regulator
GZL_RS41035	COG3321	synthase
GZL_RS41035	COG0604	alcohol dehydrogenase
GZL_RS41035	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS41065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZL_RS41075	COG0456	acetyltransferase
GZL_RS41105	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GZL_RS41105	COG3261	NADH dehydrogenase
GZL_RS41110	COG0651	ATP synthesis coupled electron transport
GZL_RS41120	COG0650	Formate hydrogenlyase subunit 4
GZL_RS41130	COG3260	NADH ubiquinone oxidoreductase 20
GZL_RS41160	COG0659	secondary active sulfate transmembrane transporter activity
GZL_RS41170	COG2824	Alkylphosphonate utilization operon protein PhnA
GZL_RS41190	COG4941	Belongs to the sigma-70 factor family
GZL_RS41195	COG3795	YCII-related domain
GZL_RS41205	COG2318	DinB family
GZL_RS41225	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GZL_RS41235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS41240	COG1021	2,3-dihydroxybenzoate-AMP ligase
GZL_RS41250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZL_RS41265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZL_RS41270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZL_RS41280	COG0167	dihydroorotate dehydrogenase activity
GZL_RS41355	COG3433	isochorismatase activity
GZL_RS41355	COG2226	methyltransferase
GZL_RS41355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZL_RS41380	COG1960	acyl-CoA dehydrogenase activity
GZL_RS41390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS41425	COG1278	Cold shock
GZL_RS41435	COG0515	serine threonine protein kinase
GZL_RS41440	COG1505	serine-type exopeptidase activity
GZL_RS41445	COG3485	protocatechuate 3,4-dioxygenase
GZL_RS41450	COG1070	Carbohydrate kinase
GZL_RS41455	COG1063	alcohol dehydrogenase
GZL_RS41465	COG2814	Major facilitator Superfamily
GZL_RS41480	COG0488	(ABC) transporter
GZL_RS41490	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS41495	COG1309	transcriptional regulator
GZL_RS41510	COG2814	Major facilitator Superfamily
GZL_RS41520	COG0656	L-ascorbic acid biosynthetic process
GZL_RS41525	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS41540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZL_RS41545	COG0390	transport system, permease component
GZL_RS41555	COG0640	Transcriptional regulator
GZL_RS41560	COG1116	anion transmembrane transporter activity
GZL_RS41585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZL_RS41600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZL_RS41605	COG0456	acetyltransferase
GZL_RS41605	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GZL_RS41630	COG1132	(ABC) transporter
GZL_RS41645	COG3320	Male sterility
GZL_RS41645	COG1022	Amp-dependent synthetase and ligase
GZL_RS41715	COG2205	protein histidine kinase activity
GZL_RS41740	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZL_RS41745	COG1129	ABC transporter
GZL_RS41760	COG0531	amino acid
GZL_RS41845	COG2132	Multicopper oxidase
GZL_RS41880	COG3328	transposase activity
GZL_RS41895	COG2239	Acts as a magnesium transporter
GZL_RS41900	COG1116	anion transmembrane transporter activity
GZL_RS41920	COG0745	RESPONSE REGULATOR receiver
GZL_RS41965	COG0789	Transcriptional regulator
GZL_RS41980	COG0495	leucyl-tRNA aminoacylation
GZL_RS41995	COG2205	protein histidine kinase activity
GZL_RS42010	COG0477	Major facilitator Superfamily
GZL_RS42060	COG3321	synthase
GZL_RS42060	COG0604	alcohol dehydrogenase
GZL_RS42060	COG0604	alcohol dehydrogenase
GZL_RS42060	COG3321	synthase
GZL_RS42065	COG3321	synthase
GZL_RS42065	COG0604	alcohol dehydrogenase
GZL_RS42070	COG0604	alcohol dehydrogenase
GZL_RS42070	COG3321	synthase
GZL_RS42080	COG3321	synthase
GZL_RS42080	COG0604	alcohol dehydrogenase
GZL_RS42095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZL_RS42110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZL_RS42115	COG3170	Tfp pilus assembly protein FimV
GZL_RS42120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GZL_RS42135	COG2318	DinB family
GZL_RS42215	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS42240	COG2205	protein histidine kinase activity
GZL_RS42245	COG0745	RESPONSE REGULATOR receiver
GZL_RS42260	COG0577	efflux transmembrane transporter activity
GZL_RS42260	COG1136	(ABC) transporter
GZL_RS42265	COG1136	(ABC) transporter
GZL_RS42265	COG0577	efflux transmembrane transporter activity
GZL_RS42285	COG2208	phosphoserine phosphatase activity
GZL_RS42285	COG2770	Histidine kinase
GZL_RS42355	COG0583	DNA-binding transcription factor activity
GZL_RS42385	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GZL_RS42530	COG3321	synthase
GZL_RS42530	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS42530	COG0604	alcohol dehydrogenase
GZL_RS42555	COG0438	transferase activity, transferring glycosyl groups
GZL_RS42575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZL_RS42580	COG3629	intracellular signal transduction
GZL_RS42585	COG3321	synthase
GZL_RS42585	COG0604	alcohol dehydrogenase
GZL_RS42590	COG3321	synthase
GZL_RS42590	COG0604	alcohol dehydrogenase
GZL_RS42590	COG0604	alcohol dehydrogenase
GZL_RS42590	COG3321	synthase
GZL_RS42625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZL_RS42645	COG1028	Short-chain dehydrogenase reductase Sdr
GZL_RS42715	COG4555	ABC transporter
GZL_RS42730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZL_RS42740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS42745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZL_RS42765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZL_RS42770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZL_RS42815	COG2267	carboxylic ester hydrolase activity
GZL_RS42820	COG2814	Major facilitator Superfamily
GZL_RS42840	COG1122	ATPase activity
GZL_RS42910	COG3328	transposase activity
GZL_RS42920	COG1473	amidohydrolase
GZL_RS43550	COG3321	synthase
GZL_RS43550	COG0604	alcohol dehydrogenase
GZL_RS44100	COG3629	intracellular signal transduction
GZL_RS44100	COG3903	Transcriptional regulator
GZL_RS44120	COG3321	synthase
GZL_RS44120	COG0604	alcohol dehydrogenase
GZL_RS44125	COG3321	synthase
GZL_RS44125	COG0604	alcohol dehydrogenase
GZL_RS44135	COG2197	response regulator
GZL_RS44140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GZL_RS44150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZL_RS44150	COG0515	serine threonine protein kinase
GZL_RS44165	COG0431	NADPH-dependent FMN reductase
GZL_RS44175	COG2226	methyltransferase
GZL_RS44260	COG0739	heme binding
GZL_RS44290	COG5280	Phage tail tape measure protein TP901
GZL_RS44290	COG3953	SLT domain
GZL_RS44305	COG2192	nodulation
GZL_RS44335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZL_RS44375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZL_RS44390	COG1136	(ABC) transporter
GZL_RS44435	COG2340	Cysteine-rich secretory protein family
GZL_RS44450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZL_RS44460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZL_RS44535	COG0456	acetyltransferase
GZL_RS44565	COG1555	photosystem II stabilization
GZL_RS44685	COG0515	serine threonine protein kinase
GZL_RS44750	COG1414	Transcriptional regulator
GZL_RS44760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZL_RS44800	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GZL_RS44815	COG2124	cytochrome p450
GZL_RS44820	COG0515	serine threonine protein kinase
GZL_RS44820	COG2815	serine threonine protein kinase
GZL_RS44875	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZL_RS44880	COG4585	Histidine kinase
GZL_RS44955	COG3903	Transcriptional regulator
GZL_RS44955	COG3629	intracellular signal transduction