locus-tag	class	description
HC362_RS00045	COG0577	efflux transmembrane transporter activity
HC362_RS00045	COG1136	(ABC) transporter
HC362_RS00170	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS00205	COG3655	Transcriptional regulator
HC362_RS00285	COG1472	Belongs to the glycosyl hydrolase 3 family
HC362_RS00290	COG0395	ABC-type sugar transport system, permease component
HC362_RS00295	COG1175	transmembrane transport
HC362_RS00365	COG1733	regulation of RNA biosynthetic process
HC362_RS00400	COG4213	ABC transporter substrate-binding protein
HC362_RS00410	COG4214	carbohydrate transport
HC362_RS00420	COG2124	cytochrome p450
HC362_RS00440	COG1609	Transcriptional regulator
HC362_RS00470	COG1621	beta-fructofuranosidase activity
HC362_RS00480	COG1595	DNA-templated transcription, initiation
HC362_RS00495	COG1966	Carbon starvation protein
HC362_RS00520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC362_RS00545	COG3655	Transcriptional regulator
HC362_RS00555	COG0235	Class ii aldolase
HC362_RS00575	COG2186	Transcriptional regulator
HC362_RS00580	COG0626	cystathionine gamma-synthase activity
HC362_RS00585	COG1757	Na H antiporter
HC362_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS00595	COG0656	L-ascorbic acid biosynthetic process
HC362_RS00600	COG2814	Major facilitator Superfamily
HC362_RS00615	COG0662	Cupin 2, conserved barrel domain protein
HC362_RS00645	COG1335	isochorismatase
HC362_RS00665	COG2318	DinB family
HC362_RS00755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC362_RS00785	COG1473	amidohydrolase
HC362_RS00790	COG1027	Aspartate ammonia-lyase
HC362_RS00800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HC362_RS00805	COG1309	transcriptional regulator
HC362_RS00825	COG1959	2 iron, 2 sulfur cluster binding
HC362_RS00830	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS00835	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC362_RS00840	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC362_RS00850	COG0395	ABC-type sugar transport system, permease component
HC362_RS00855	COG1175	transmembrane transport
HC362_RS00875	COG2340	Cysteine-rich secretory protein family
HC362_RS00905	COG0437	4 iron, 4 sulfur cluster binding
HC362_RS00910	COG3383	formate dehydrogenase (NAD+) activity
HC362_RS00910	COG0243	molybdopterin cofactor binding
HC362_RS00920	COG2192	nodulation
HC362_RS00925	COG0577	efflux transmembrane transporter activity
HC362_RS00930	COG0577	efflux transmembrane transporter activity
HC362_RS00930	COG1136	(ABC) transporter
HC362_RS00945	COG0745	RESPONSE REGULATOR receiver
HC362_RS00950	COG2205	protein histidine kinase activity
HC362_RS00985	COG1940	carbohydrate kinase activity
HC362_RS01010	COG1846	Transcriptional regulator
HC362_RS01010	COG1940	carbohydrate kinase activity
HC362_RS01030	COG0488	(ABC) transporter
HC362_RS01035	COG1959	2 iron, 2 sulfur cluster binding
HC362_RS01040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC362_RS01050	COG0596	Alpha beta hydrolase
HC362_RS01060	COG0539	negative regulation of cytoplasmic translation
HC362_RS01070	COG0557	exoribonuclease II activity
HC362_RS01085	COG0667	Aldo Keto reductase
HC362_RS01095	COG4552	Acetyltransferase involved in intracellular survival and related
HC362_RS01130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC362_RS01135	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HC362_RS01145	COG1461	Dihydroxyacetone kinase
HC362_RS01150	COG2376	Dihydroxyacetone kinase
HC362_RS01160	COG4977	sequence-specific DNA binding
HC362_RS01170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC362_RS01175	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC362_RS01185	COG1216	Glycosyl transferase, family 2
HC362_RS01195	COG4310	Domain of unknown function (DUF2172)
HC362_RS01210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC362_RS01245	COG0367	asparagine synthase
HC362_RS01265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC362_RS01275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC362_RS01280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC362_RS01295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC362_RS01360	COG0577	efflux transmembrane transporter activity
HC362_RS01360	COG1136	(ABC) transporter
HC362_RS01370	COG1653	transport
HC362_RS01375	COG0366	Alpha amylase catalytic
HC362_RS01380	COG1653	transport
HC362_RS01385	COG1175	transmembrane transport
HC362_RS01390	COG0395	ABC-type sugar transport system, permease component
HC362_RS01395	COG0596	Alpha beta hydrolase
HC362_RS01405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC362_RS01410	COG1309	transcriptional regulator
HC362_RS01435	COG0251	oxidation-reduction process
HC362_RS01445	COG0456	acetyltransferase
HC362_RS01475	COG1132	(ABC) transporter
HC362_RS01490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC362_RS01495	COG2226	methyltransferase
HC362_RS01500	COG0328	RNA-DNA hybrid ribonuclease activity
HC362_RS01545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC362_RS01560	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC362_RS01565	COG0596	Alpha beta hydrolase
HC362_RS01585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC362_RS01600	COG1335	isochorismatase
HC362_RS01605	COG2207	Transcriptional regulator
HC362_RS01630	COG1802	Transcriptional regulator
HC362_RS01640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC362_RS01645	COG2233	PERMEase
HC362_RS01650	COG0402	S-adenosylhomocysteine deaminase activity
HC362_RS01660	COG1609	Transcriptional regulator
HC362_RS01680	COG1595	DNA-templated transcription, initiation
HC362_RS01775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS01790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS01795	COG0151	Belongs to the GarS family
HC362_RS01800	COG0778	Nitroreductase
HC362_RS01825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC362_RS01840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC362_RS01850	COG2208	phosphoserine phosphatase activity
HC362_RS01850	COG2770	Histidine kinase
HC362_RS01855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC362_RS01890	COG0513	Belongs to the DEAD box helicase family
HC362_RS01925	COG0277	FAD linked oxidase domain protein
HC362_RS01990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC362_RS02005	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HC362_RS02020	COG0142	geranyltranstransferase activity
HC362_RS02030	COG0137	argininosuccinate synthase activity
HC362_RS02045	COG1609	Transcriptional regulator
HC362_RS02050	COG1278	Cold shock
HC362_RS02055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC362_RS02100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC362_RS02105	COG2124	cytochrome p450
HC362_RS02130	COG3896	Chloramphenicol phosphotransferase-like protein
HC362_RS02135	COG1470	cell adhesion involved in biofilm formation
HC362_RS02140	COG1764	response to oxidative stress
HC362_RS02145	COG1846	Transcriptional regulator
HC362_RS02170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC362_RS02180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC362_RS02185	COG2770	Histidine kinase
HC362_RS02185	COG2208	phosphoserine phosphatase activity
HC362_RS02195	COG2197	response regulator
HC362_RS02215	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC362_RS02225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC362_RS02235	COG1136	(ABC) transporter
HC362_RS02235	COG0577	efflux transmembrane transporter activity
HC362_RS02240	COG1136	(ABC) transporter
HC362_RS02240	COG0577	efflux transmembrane transporter activity
HC362_RS02325	COG1505	serine-type exopeptidase activity
HC362_RS02380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC362_RS02385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC362_RS02390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS02400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS02440	COG0583	DNA-binding transcription factor activity
HC362_RS02445	COG1271	oxidase subunit
HC362_RS02455	COG4988	ABC transporter
HC362_RS02460	COG1132	(ABC) transporter
HC362_RS02470	COG1115	amino acid carrier protein
HC362_RS02515	COG0569	domain protein
HC362_RS02520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC362_RS02530	COG0542	response to heat
HC362_RS02535	COG2755	lipolytic protein G-D-S-L family
HC362_RS02540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC362_RS02550	COG2226	methyltransferase
HC362_RS02560	COG0640	Transcriptional regulator
HC362_RS02570	COG0596	Alpha beta hydrolase
HC362_RS02585	COG2890	protein-(glutamine-N5) methyltransferase activity
HC362_RS02595	COG2124	cytochrome p450
HC362_RS02600	COG2124	cytochrome p450
HC362_RS02605	COG0577	efflux transmembrane transporter activity
HC362_RS02605	COG1136	(ABC) transporter
HC362_RS02610	COG1136	(ABC) transporter
HC362_RS02610	COG4591	ABC-type transport system involved in lipoprotein release permease component
HC362_RS02615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC362_RS02655	COG0346	lactoylglutathione lyase activity
HC362_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS02725	COG0671	phosphoesterase, PA-phosphatase related
HC362_RS02730	COG1309	transcriptional regulator
HC362_RS02755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC362_RS02760	COG2971	BadF BadG BcrA BcrD
HC362_RS02780	COG0546	phosphoglycolate phosphatase activity
HC362_RS02795	COG1309	transcriptional regulator
HC362_RS02805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC362_RS02845	COG1609	Transcriptional regulator
HC362_RS02850	COG1879	ABC-type sugar transport system periplasmic component
HC362_RS02865	COG1129	ABC transporter
HC362_RS02875	COG1070	Carbohydrate kinase
HC362_RS02880	COG0247	lactate metabolic process
HC362_RS02885	COG1139	Iron-sulfur cluster binding protein
HC362_RS02890	COG1556	Lactate utilization protein
HC362_RS02910	COG1119	ATPase activity
HC362_RS02925	COG3876	Protein conserved in bacteria
HC362_RS02930	COG1132	(ABC) transporter
HC362_RS02960	COG1132	(ABC) transporter
HC362_RS02965	COG1132	(ABC) transporter
HC362_RS02980	COG1946	Acyl-CoA thioesterase
HC362_RS02990	COG2018	Roadblock/LC7 domain
HC362_RS03020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC362_RS03065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC362_RS03070	COG0765	amino acid transport
HC362_RS03095	COG1940	carbohydrate kinase activity
HC362_RS03115	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS03120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS03125	COG2197	response regulator
HC362_RS03170	COG0596	Alpha beta hydrolase
HC362_RS03210	COG0745	RESPONSE REGULATOR receiver
HC362_RS03215	COG2205	protein histidine kinase activity
HC362_RS03230	COG0583	DNA-binding transcription factor activity
HC362_RS03285	COG1653	transport
HC362_RS03290	COG1175	transmembrane transport
HC362_RS03295	COG0395	ABC-type sugar transport system, permease component
HC362_RS03340	COG1609	Transcriptional regulator
HC362_RS03350	COG1653	transport
HC362_RS03365	COG0366	Alpha amylase catalytic
HC362_RS03370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC362_RS03375	COG1349	DNA-binding transcription factor activity
HC362_RS03380	COG1063	alcohol dehydrogenase
HC362_RS03385	COG1063	alcohol dehydrogenase
HC362_RS03390	COG0395	ABC-type sugar transport system, permease component
HC362_RS03465	COG2311	Membrane
HC362_RS03485	COG3903	Transcriptional regulator
HC362_RS03485	COG3629	intracellular signal transduction
HC362_RS03525	COG0741	lytic transglycosylase activity
HC362_RS03525	COG0739	heme binding
HC362_RS03525	COG1196	nuclear chromosome segregation
HC362_RS03565	COG0574	Belongs to the PEP-utilizing enzyme family
HC362_RS03565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC362_RS03580	COG2084	Dehydrogenase
HC362_RS03595	COG4977	sequence-specific DNA binding
HC362_RS03605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC362_RS03625	COG1309	transcriptional regulator
HC362_RS03665	COG4585	Histidine kinase
HC362_RS03670	COG2197	response regulator
HC362_RS03700	COG4106	trans-aconitate 2-methyltransferase activity
HC362_RS03720	COG0071	Belongs to the small heat shock protein (HSP20) family
HC362_RS03730	COG4221	oxidoreductase activity
HC362_RS03740	COG0726	polysaccharide deacetylase
HC362_RS03745	COG1070	Carbohydrate kinase
HC362_RS03755	COG0505	Belongs to the CarA family
HC362_RS03785	COG1278	Cold shock
HC362_RS03825	COG1063	alcohol dehydrogenase
HC362_RS03860	COG0301	tRNA thio-modification
HC362_RS03870	COG1024	Enoyl-CoA hydratase
HC362_RS03875	COG0515	serine threonine protein kinase
HC362_RS03885	COG1132	(ABC) transporter
HC362_RS03890	COG1132	(ABC) transporter
HC362_RS03895	COG2197	response regulator
HC362_RS03915	COG1982	Orn Lys Arg decarboxylase major
HC362_RS03940	COG2226	methyltransferase
HC362_RS03945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC362_RS03950	COG0737	Belongs to the 5'-nucleotidase family
HC362_RS03965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC362_RS03970	COG3387	PFAM Glycoside hydrolase 15-related
HC362_RS03975	COG0517	IMP dehydrogenase activity
HC362_RS04005	COG0435	Glutathione S-transferase
HC362_RS04055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC362_RS04060	COG1349	DNA-binding transcription factor activity
HC362_RS04125	COG2197	response regulator
HC362_RS04140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC362_RS04185	COG0492	ferredoxin-NADP+ reductase activity
HC362_RS04190	COG1501	Belongs to the glycosyl hydrolase 31 family
HC362_RS04200	COG0395	ABC-type sugar transport system, permease component
HC362_RS04205	COG1175	transmembrane transport
HC362_RS04210	COG1653	transport
HC362_RS04215	COG1472	Belongs to the glycosyl hydrolase 3 family
HC362_RS04220	COG1609	Transcriptional regulator
HC362_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS04245	COG0110	maltose O-acetyltransferase activity
HC362_RS04255	COG0662	Cupin 2, conserved barrel domain protein
HC362_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS04320	COG2146	nitrite reductase [NAD(P)H] activity
HC362_RS04325	COG1414	Transcriptional regulator
HC362_RS04340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC362_RS04350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC362_RS04360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC362_RS04365	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS04380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC362_RS04405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC362_RS04435	COG1175	transmembrane transport
HC362_RS04440	COG1653	transport
HC362_RS04445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS04450	COG1349	DNA-binding transcription factor activity
HC362_RS04455	COG1486	melibiose metabolic process
HC362_RS04470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC362_RS04570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HC362_RS04580	COG1127	ABC transporter
HC362_RS04610	COG1960	acyl-CoA dehydrogenase activity
HC362_RS04615	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC362_RS04620	COG0583	DNA-binding transcription factor activity
HC362_RS04625	COG0183	Belongs to the thiolase family
HC362_RS04650	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS04655	COG2197	response regulator
HC362_RS04670	COG0375	protein maturation
HC362_RS04675	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HC362_RS04685	COG0298	carbon dioxide binding
HC362_RS04695	COG0309	Hydrogenase expression formation protein (HypE)
HC362_RS04700	COG1024	Enoyl-CoA hydratase
HC362_RS04700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC362_RS04715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC362_RS04720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC362_RS04725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HC362_RS04730	COG0254	rRNA binding
HC362_RS04740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC362_RS04760	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HC362_RS04770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HC362_RS04795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC362_RS04810	COG1793	dna ligase
HC362_RS04815	COG1793	dna ligase
HC362_RS04825	COG0656	L-ascorbic acid biosynthetic process
HC362_RS04830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC362_RS04845	COG3973	AAA domain
HC362_RS04895	COG1960	acyl-CoA dehydrogenase activity
HC362_RS04900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC362_RS04900	COG0723	plastoquinol--plastocyanin reductase activity
HC362_RS04915	COG1124	(ABC) transporter
HC362_RS04920	COG0444	Belongs to the ABC transporter superfamily
HC362_RS04925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC362_RS04945	COG5001	Diguanylate cyclase
HC362_RS04975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC362_RS04995	COG1657	PFAM Prenyltransferase squalene oxidase
HC362_RS05005	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HC362_RS05015	COG1562	ergosterol biosynthetic process
HC362_RS05025	COG2409	Drug exporters of the RND superfamily
HC362_RS05030	COG1134	teichoic acid transport
HC362_RS05070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HC362_RS05080	COG1024	Enoyl-CoA hydratase
HC362_RS05090	COG2183	response to ionizing radiation
HC362_RS05105	COG0488	(ABC) transporter
HC362_RS05110	COG1940	carbohydrate kinase activity
HC362_RS05115	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HC362_RS05140	COG0642	Histidine kinase
HC362_RS05180	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC362_RS05180	COG1024	Enoyl-CoA hydratase
HC362_RS05185	COG0183	Belongs to the thiolase family
HC362_RS05190	COG1960	acyl-CoA dehydrogenase activity
HC362_RS05195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HC362_RS05205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC362_RS05210	COG0191	fructose-bisphosphate aldolase activity
HC362_RS05215	COG1349	DNA-binding transcription factor activity
HC362_RS05240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HC362_RS05250	COG3409	Peptidoglycan-binding domain 1 protein
HC362_RS05250	COG3757	hydrolase, family 25
HC362_RS05260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC362_RS05265	COG3268	Saccharopine dehydrogenase
HC362_RS05275	COG3012	SEC-C Motif Domain Protein
HC362_RS05280	COG1278	Cold shock
HC362_RS05310	COG2409	Drug exporters of the RND superfamily
HC362_RS05320	COG2197	response regulator
HC362_RS05325	COG4585	Histidine kinase
HC362_RS05340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS05345	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC362_RS05360	COG2050	protein possibly involved in aromatic compounds catabolism
HC362_RS05415	COG1515	deoxyribonuclease V activity
HC362_RS05435	COG2610	gluconate transmembrane transporter activity
HC362_RS05460	COG0142	geranyltranstransferase activity
HC362_RS05465	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC362_RS05490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC362_RS05505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC362_RS05515	COG0714	Associated with various cellular activities
HC362_RS05545	COG1674	ftsk spoiiie
HC362_RS05580	COG1295	ribonuclease BN
HC362_RS05605	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HC362_RS05630	COG2890	protein-(glutamine-N5) methyltransferase activity
HC362_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS05660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC362_RS05670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC362_RS05675	COG0247	lactate metabolic process
HC362_RS05675	COG0277	FAD linked oxidase domain protein
HC362_RS05680	COG4948	Mandelate Racemase Muconate Lactonizing
HC362_RS05685	COG0028	Belongs to the TPP enzyme family
HC362_RS05710	COG2837	iron assimilation
HC362_RS05715	COG0672	)-iron permease
HC362_RS05745	COG1007	ATP synthesis coupled electron transport
HC362_RS05760	COG0713	ATP synthesis coupled electron transport
HC362_RS05770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HC362_RS05780	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS05840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC362_RS05845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC362_RS05855	COG3290	protein histidine kinase activity
HC362_RS05860	COG4565	transcriptional regulatory protein
HC362_RS05880	COG4585	Histidine kinase
HC362_RS05910	COG2205	protein histidine kinase activity
HC362_RS05910	COG3437	response regulator, receiver
HC362_RS05910	COG3850	Histidine kinase
HC362_RS05910	COG4999	Histidine kinase
HC362_RS05925	COG0697	spore germination
HC362_RS05985	COG0582	viral genome integration into host DNA
HC362_RS06020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC362_RS06105	COG1674	ftsk spoiiie
HC362_RS06195	COG0673	inositol 2-dehydrogenase activity
HC362_RS06200	COG1879	ABC-type sugar transport system periplasmic component
HC362_RS06205	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC362_RS06210	COG1129	ABC transporter
HC362_RS06215	COG1940	carbohydrate kinase activity
HC362_RS06220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC362_RS06230	COG0656	L-ascorbic acid biosynthetic process
HC362_RS06235	COG2154	pterin-4-alpha-carbinolamine dehydratase
HC362_RS06285	COG0516	GMP reductase activity
HC362_RS06285	COG0517	IMP dehydrogenase activity
HC362_RS06290	COG4106	trans-aconitate 2-methyltransferase activity
HC362_RS06300	COG2197	response regulator
HC362_RS06305	COG4585	Histidine kinase
HC362_RS06310	COG0586	Pfam SNARE associated Golgi protein
HC362_RS06335	COG1506	peptidase
HC362_RS06335	COG0823	Involved in the tonB-independent uptake of proteins
HC362_RS06335	COG4946	Tricorn protease homolog
HC362_RS06340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC362_RS06345	COG2362	D-Aminopeptidase
HC362_RS06375	COG1032	radical SAM domain protein
HC362_RS06390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC362_RS06400	COG0531	amino acid
HC362_RS06410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HC362_RS06410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HC362_RS06415	COG2301	Belongs to the HpcH HpaI aldolase family
HC362_RS06425	COG1960	acyl-CoA dehydrogenase activity
HC362_RS06430	COG0688	phosphatidylethanolamine metabolic process
HC362_RS06440	COG1929	Belongs to the glycerate kinase type-1 family
HC362_RS06450	COG0483	inositol monophosphate 1-phosphatase activity
HC362_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS06480	COG0702	epimerase
HC362_RS06495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC362_RS06500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC362_RS06520	COG0405	Gamma-glutamyltransferase
HC362_RS06530	COG0765	amino acid transport
HC362_RS06535	COG0765	amino acid transport
HC362_RS06540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC362_RS06545	COG1126	abc transporter atp-binding protein
HC362_RS06570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC362_RS06580	COG1940	carbohydrate kinase activity
HC362_RS06600	COG2188	Transcriptional regulator
HC362_RS06620	COG0800	Aldolase
HC362_RS06625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS06635	COG4266	Belongs to the allantoicase family
HC362_RS06640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC362_RS06645	COG1414	Transcriptional regulator
HC362_RS06660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HC362_RS06680	COG1733	regulation of RNA biosynthetic process
HC362_RS06685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC362_RS06705	COG2233	PERMEase
HC362_RS06720	COG2351	hydroxyisourate hydrolase activity
HC362_RS06745	COG3622	Belongs to the hyi family
HC362_RS06750	COG2084	Dehydrogenase
HC362_RS06755	COG3960	tartronate-semialdehyde synthase activity
HC362_RS06775	COG0753	catalase activity
HC362_RS06785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC362_RS06800	COG2252	PERMEase
HC362_RS06805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC362_RS06820	COG3835	regulator
HC362_RS06825	COG2201	protein-glutamate methylesterase activity
HC362_RS06835	COG0438	transferase activity, transferring glycosyl groups
HC362_RS06865	COG2814	Major facilitator Superfamily
HC362_RS06890	COG1162	GTPase activity
HC362_RS06900	COG1960	acyl-CoA dehydrogenase activity
HC362_RS06915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS06920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS06935	COG0477	Major facilitator Superfamily
HC362_RS06965	COG0789	Transcriptional regulator
HC362_RS06970	COG3467	pyridoxamine 5'-phosphate
HC362_RS06985	COG1254	Belongs to the acylphosphatase family
HC362_RS07030	COG0175	sulfate reduction
HC362_RS07035	COG0529	Catalyzes the synthesis of activated sulfate
HC362_RS07060	COG1116	anion transmembrane transporter activity
HC362_RS07065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC362_RS07100	COG0583	DNA-binding transcription factor activity
HC362_RS07110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC362_RS07125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC362_RS07130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC362_RS07160	COG1116	anion transmembrane transporter activity
HC362_RS07180	COG3253	May function as heme-dependent peroxidase
HC362_RS07185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HC362_RS07190	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC362_RS07195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC362_RS07215	COG0183	Belongs to the thiolase family
HC362_RS07220	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC362_RS07220	COG1024	Enoyl-CoA hydratase
HC362_RS07240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC362_RS07250	COG4214	carbohydrate transport
HC362_RS07260	COG4213	ABC transporter substrate-binding protein
HC362_RS07265	COG1940	carbohydrate kinase activity
HC362_RS07270	COG0395	ABC-type sugar transport system, permease component
HC362_RS07285	COG0395	ABC-type sugar transport system, permease component
HC362_RS07290	COG1175	transmembrane transport
HC362_RS07310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC362_RS07320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC362_RS07365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC362_RS07385	COG1960	acyl-CoA dehydrogenase activity
HC362_RS07410	COG1902	pentaerythritol trinitrate reductase activity
HC362_RS07415	COG1024	Enoyl-CoA hydratase
HC362_RS07450	COG2040	homocysteine
HC362_RS07460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC362_RS07465	COG0531	amino acid
HC362_RS07495	COG0656	L-ascorbic acid biosynthetic process
HC362_RS07500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC362_RS07505	COG3457	Alanine racemase
HC362_RS07510	COG0626	cystathionine gamma-synthase activity
HC362_RS07515	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HC362_RS07535	COG2188	Transcriptional regulator
HC362_RS07545	COG0019	diaminopimelate decarboxylase activity
HC362_RS07610	COG0745	RESPONSE REGULATOR receiver
HC362_RS07615	COG2205	protein histidine kinase activity
HC362_RS07645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC362_RS07650	COG0531	amino acid
HC362_RS07655	COG0569	domain protein
HC362_RS07665	COG1470	cell adhesion involved in biofilm formation
HC362_RS07695	COG0756	dUTP diphosphatase activity
HC362_RS07720	COG2205	protein histidine kinase activity
HC362_RS07725	COG0745	RESPONSE REGULATOR receiver
HC362_RS07740	COG0483	inositol monophosphate 1-phosphatase activity
HC362_RS07745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HC362_RS07775	COG1435	thymidine kinase activity
HC362_RS07790	COG0045	succinate-CoA ligase (ADP-forming) activity
HC362_RS07790	COG1042	CoA-binding domain protein
HC362_RS07790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC362_RS07795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC362_RS07800	COG0739	heme binding
HC362_RS07810	COG0612	Peptidase, M16
HC362_RS07815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC362_RS07830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC362_RS07840	COG0187	DNA topoisomerase II activity
HC362_RS07855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC362_RS07865	COG1131	(ABC) transporter
HC362_RS07890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC362_RS07900	COG0588	phosphoglycerate mutase activity
HC362_RS07910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC362_RS07915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC362_RS07920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC362_RS07955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC362_RS07965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC362_RS07970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC362_RS07980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC362_RS08000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC362_RS08010	COG2358	TRAP transporter, solute receptor (TAXI family
HC362_RS08020	COG2205	protein histidine kinase activity
HC362_RS08025	COG0745	RESPONSE REGULATOR receiver
HC362_RS08030	COG1126	abc transporter atp-binding protein
HC362_RS08035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC362_RS08040	COG0765	amino acid transport
HC362_RS08045	COG0765	amino acid transport
HC362_RS08065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HC362_RS08095	COG1201	RNA secondary structure unwinding
HC362_RS08105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC362_RS08120	COG1396	sequence-specific DNA binding
HC362_RS08125	COG1546	Belongs to the CinA family
HC362_RS08125	COG1058	Belongs to the CinA family
HC362_RS08135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC362_RS08145	COG1674	ftsk spoiiie
HC362_RS08155	COG2205	protein histidine kinase activity
HC362_RS08155	COG3437	response regulator, receiver
HC362_RS08155	COG3850	Histidine kinase
HC362_RS08155	COG4999	Histidine kinase
HC362_RS08160	COG2770	Histidine kinase
HC362_RS08160	COG2208	phosphoserine phosphatase activity
HC362_RS08190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC362_RS08195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC362_RS08200	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HC362_RS08225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC362_RS08230	COG0612	Peptidase, M16
HC362_RS08235	COG1185	polyribonucleotide nucleotidyltransferase activity
HC362_RS08240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HC362_RS08250	COG1674	ftsk spoiiie
HC362_RS08265	COG0515	serine threonine protein kinase
HC362_RS08265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC362_RS08290	COG1404	Belongs to the peptidase S8 family
HC362_RS08310	COG3266	domain, Protein
HC362_RS08325	COG0455	bacterial-type flagellum organization
HC362_RS08340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC362_RS08345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC362_RS08355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC362_RS08370	COG0779	Required for maturation of 30S ribosomal subunits
HC362_RS08385	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HC362_RS08390	COG0442	prolyl-tRNA aminoacylation
HC362_RS08405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC362_RS08410	COG0750	zinc metalloprotease
HC362_RS08415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC362_RS08435	COG2197	response regulator
HC362_RS08440	COG4585	Histidine kinase
HC362_RS08465	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS08470	COG2508	Transcriptional regulator
HC362_RS08490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC362_RS08500	COG1176	ABC-type spermidine putrescine transport system, permease component I
HC362_RS08505	COG3842	ATPase activity
HC362_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS08525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HC362_RS08540	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS08550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC362_RS08555	COG1136	(ABC) transporter
HC362_RS08565	COG3842	ATPase activity
HC362_RS08580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC362_RS08585	COG0575	Belongs to the CDS family
HC362_RS08590	COG0233	cytoplasmic translational termination
HC362_RS08595	COG0528	UMP kinase activity
HC362_RS08600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC362_RS08605	COG0052	Belongs to the universal ribosomal protein uS2 family
HC362_RS08620	COG1191	sigma factor activity
HC362_RS08635	COG0792	nuclease activity
HC362_RS08645	COG0681	Belongs to the peptidase S26 family
HC362_RS08650	COG0681	Belongs to the peptidase S26 family
HC362_RS08655	COG0681	Belongs to the peptidase S26 family
HC362_RS08665	COG0335	large ribosomal subunit rRNA binding
HC362_RS08670	COG0336	Belongs to the RNA methyltransferase TrmD family
HC362_RS08675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC362_RS08680	COG1837	Belongs to the UPF0109 family
HC362_RS08685	COG0228	four-way junction DNA binding
HC362_RS08710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HC362_RS08745	COG0477	Major facilitator Superfamily
HC362_RS08750	COG1196	nuclear chromosome segregation
HC362_RS08760	COG1254	Belongs to the acylphosphatase family
HC362_RS08770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC362_RS08775	COG0571	ribonuclease III activity
HC362_RS08780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HC362_RS08795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC362_RS08800	COG0742	ribosomal rna small subunit methyltransferase
HC362_RS08815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC362_RS08820	COG0351	phosphomethylpyrimidine kinase
HC362_RS08840	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC362_RS08845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC362_RS08855	COG1920	GTP binding
HC362_RS08865	COG0776	regulation of translation
HC362_RS08875	COG0066	3-isopropylmalate dehydratase activity
HC362_RS08880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC362_RS08885	COG1414	Transcriptional regulator
HC362_RS08915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC362_RS08920	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC362_RS08935	COG2018	Roadblock/LC7 domain
HC362_RS08955	COG2018	Roadblock/LC7 domain
HC362_RS08975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC362_RS08985	COG0832	Belongs to the urease beta subunit family
HC362_RS08985	COG0831	urea catabolic process
HC362_RS08990	COG0804	urea catabolic process
HC362_RS08995	COG2957	Belongs to the agmatine deiminase family
HC362_RS09005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC362_RS09025	COG3540	Alkaline phosphatase
HC362_RS09030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC362_RS09035	COG0473	3-isopropylmalate dehydrogenase activity
HC362_RS09045	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS09050	COG0506	proline dehydrogenase activity
HC362_RS09055	COG3835	regulator
HC362_RS09065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC362_RS09070	COG0440	acetolactate synthase activity
HC362_RS09090	COG0667	Aldo Keto reductase
HC362_RS09095	COG2133	pyrroloquinoline quinone binding
HC362_RS09105	COG2197	response regulator
HC362_RS09120	COG2409	Drug exporters of the RND superfamily
HC362_RS09150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC362_RS09160	COG0154	amidase activity
HC362_RS09165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC362_RS09200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC362_RS09210	COG4221	oxidoreductase activity
HC362_RS09215	COG1077	Cell shape determining protein MreB Mrl
HC362_RS09230	COG1611	Belongs to the LOG family
HC362_RS09235	COG0482	sulfurtransferase activity
HC362_RS09250	COG0783	Belongs to the Dps family
HC362_RS09260	COG2860	membrane
HC362_RS09265	COG4608	Belongs to the ABC transporter superfamily
HC362_RS09280	COG4166	transmembrane transport
HC362_RS09285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC362_RS09310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC362_RS09315	COG0509	glycine decarboxylation via glycine cleavage system
HC362_RS09320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC362_RS09325	COG1760	l-serine dehydratase
HC362_RS09330	COG1595	DNA-templated transcription, initiation
HC362_RS09335	COG1090	epimerase
HC362_RS09345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC362_RS09360	COG0783	Belongs to the Dps family
HC362_RS09415	COG0366	Alpha amylase catalytic
HC362_RS09430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC362_RS09435	COG1301	dicarboxylic acid transport
HC362_RS09440	COG3290	protein histidine kinase activity
HC362_RS09445	COG4565	transcriptional regulatory protein
HC362_RS09465	COG0395	ABC-type sugar transport system, permease component
HC362_RS09475	COG2814	Major facilitator Superfamily
HC362_RS09480	COG0205	6-phosphofructokinase activity
HC362_RS09485	COG0280	phosphate acetyltransferase
HC362_RS09485	COG0857	belongs to the CobB CobQ family
HC362_RS09490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC362_RS09530	COG2205	protein histidine kinase activity
HC362_RS09535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HC362_RS09535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HC362_RS09585	COG5002	protein histidine kinase activity
HC362_RS09590	COG0745	RESPONSE REGULATOR receiver
HC362_RS09605	COG0183	Belongs to the thiolase family
HC362_RS09625	COG1131	(ABC) transporter
HC362_RS09660	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HC362_RS09680	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC362_RS09730	COG2197	response regulator
HC362_RS09740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HC362_RS09745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC362_RS09750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC362_RS09755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC362_RS09760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC362_RS09765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC362_RS09770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC362_RS09790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC362_RS09800	COG2890	protein-(glutamine-N5) methyltransferase activity
HC362_RS09805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC362_RS09810	COG0254	rRNA binding
HC362_RS09825	COG0083	homoserine kinase activity
HC362_RS09830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC362_RS09840	COG0019	diaminopimelate decarboxylase activity
HC362_RS09845	COG0018	arginyl-trna synthetase
HC362_RS09880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC362_RS09935	COG0443	Heat shock 70 kDa protein
HC362_RS09970	COG0791	NLP P60 protein
HC362_RS10000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC362_RS10010	COG0745	RESPONSE REGULATOR receiver
HC362_RS10015	COG2205	protein histidine kinase activity
HC362_RS10020	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC362_RS10020	COG0567	Dehydrogenase, E1 component
HC362_RS10040	COG2255	four-way junction helicase activity
HC362_RS10075	COG4585	Histidine kinase
HC362_RS10090	COG1695	Transcriptional regulator
HC362_RS10105	COG1960	acyl-CoA dehydrogenase activity
HC362_RS10110	COG1960	acyl-CoA dehydrogenase activity
HC362_RS10115	COG1024	Enoyl-CoA hydratase
HC362_RS10125	COG1309	transcriptional regulator
HC362_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS10145	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS10150	COG1024	Enoyl-CoA hydratase
HC362_RS10165	COG2070	2-Nitropropane dioxygenase
HC362_RS10180	COG0604	alcohol dehydrogenase
HC362_RS10195	COG1126	abc transporter atp-binding protein
HC362_RS10200	COG0765	amino acid transport
HC362_RS10205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC362_RS10210	COG0281	malic enzyme
HC362_RS10215	COG4106	trans-aconitate 2-methyltransferase activity
HC362_RS10235	COG2124	cytochrome p450
HC362_RS10245	COG3424	synthase
HC362_RS10345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HC362_RS10365	COG1597	lipid kinase activity
HC362_RS10380	COG0235	Class ii aldolase
HC362_RS10385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC362_RS10390	COG1472	Belongs to the glycosyl hydrolase 3 family
HC362_RS10395	COG0395	ABC-type sugar transport system, permease component
HC362_RS10400	COG1175	transmembrane transport
HC362_RS10405	COG2182	Extracellular solute-binding protein
HC362_RS10410	COG2188	Transcriptional regulator
HC362_RS10415	COG1966	Carbon starvation protein
HC362_RS10435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC362_RS10440	COG0242	peptide deformylase activity
HC362_RS10460	COG5662	AntiSigma factor
HC362_RS10465	COG1595	DNA-templated transcription, initiation
HC362_RS10475	COG2135	peptidase activity
HC362_RS10485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC362_RS10490	COG1162	GTPase activity
HC362_RS10495	COG2076	Multidrug Resistance protein
HC362_RS10505	COG0483	inositol monophosphate 1-phosphatase activity
HC362_RS10515	COG0753	catalase activity
HC362_RS10540	COG1615	UPF0182 protein
HC362_RS10550	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC362_RS10590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HC362_RS10625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC362_RS10630	COG0210	DNA helicase
HC362_RS10720	COG0596	Alpha beta hydrolase
HC362_RS10725	COG2095	MarC family integral membrane protein
HC362_RS10730	COG0613	PHP domain protein
HC362_RS10740	COG2814	Major facilitator Superfamily
HC362_RS10750	COG0598	Magnesium transport protein CorA
HC362_RS10765	COG2239	Acts as a magnesium transporter
HC362_RS10785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC362_RS10790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC362_RS10800	COG1595	DNA-templated transcription, initiation
HC362_RS10815	COG1024	Enoyl-CoA hydratase
HC362_RS10820	COG0519	Catalyzes the synthesis of GMP from XMP
HC362_RS10830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC362_RS10835	COG1611	Belongs to the LOG family
HC362_RS10840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC362_RS10860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC362_RS10885	COG2197	response regulator
HC362_RS10890	COG4585	Histidine kinase
HC362_RS10900	COG1131	(ABC) transporter
HC362_RS10915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC362_RS10930	COG4608	Belongs to the ABC transporter superfamily
HC362_RS10935	COG0444	Belongs to the ABC transporter superfamily
HC362_RS10940	COG0601	transmembrane transport
HC362_RS10945	COG4166	transmembrane transport
HC362_RS10950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC362_RS10960	COG4608	Belongs to the ABC transporter superfamily
HC362_RS10965	COG0444	Belongs to the ABC transporter superfamily
HC362_RS10970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC362_RS10975	COG0601	transmembrane transport
HC362_RS10980	COG0747	negative chemotaxis
HC362_RS10985	COG4608	Belongs to the ABC transporter superfamily
HC362_RS10990	COG0444	Belongs to the ABC transporter superfamily
HC362_RS10995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC362_RS11000	COG0601	transmembrane transport
HC362_RS11010	COG1217	gtp-binding protein TYPA
HC362_RS11035	COG1053	succinate dehydrogenase
HC362_RS11045	COG4585	Histidine kinase
HC362_RS11055	COG0671	phosphoesterase, PA-phosphatase related
HC362_RS11100	COG4585	Histidine kinase
HC362_RS11105	COG2197	response regulator
HC362_RS11110	COG2197	response regulator
HC362_RS11190	COG0012	GTP binding
HC362_RS11200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC362_RS11210	COG1570	exodeoxyribonuclease VII activity
HC362_RS11215	COG1722	exodeoxyribonuclease VII activity
HC362_RS11220	COG0778	Nitroreductase
HC362_RS11245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HC362_RS11245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HC362_RS11260	COG0114	fumarate hydratase activity
HC362_RS11270	COG2226	methyltransferase
HC362_RS11280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC362_RS11285	COG0450	alkyl hydroperoxide reductase
HC362_RS11325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC362_RS11330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC362_RS11335	COG0667	Aldo Keto reductase
HC362_RS11360	COG2885	chlorophyll binding
HC362_RS11400	COG2894	cell division
HC362_RS11435	COG2610	gluconate transmembrane transporter activity
HC362_RS11440	COG0251	oxidation-reduction process
HC362_RS11445	COG1414	Transcriptional regulator
HC362_RS11460	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HC362_RS11475	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HC362_RS11485	COG0436	Aminotransferase
HC362_RS11490	COG1309	transcriptional regulator
HC362_RS11495	COG1331	Highly conserved protein containing a thioredoxin domain
HC362_RS11530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC362_RS11545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC362_RS11555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC362_RS11565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC362_RS11595	COG2018	Roadblock/LC7 domain
HC362_RS11615	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC362_RS11620	COG3415	Transposase
HC362_RS11620	COG2801	Transposase and inactivated derivatives
HC362_RS11625	COG1733	regulation of RNA biosynthetic process
HC362_RS11670	COG1024	Enoyl-CoA hydratase
HC362_RS11675	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HC362_RS11685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC362_RS11700	COG0424	maF-like protein
HC362_RS11710	COG4770	biotin carboxylase activity
HC362_RS11740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC362_RS11790	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS11795	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS11805	COG1733	regulation of RNA biosynthetic process
HC362_RS11845	COG1595	DNA-templated transcription, initiation
HC362_RS11850	COG0745	RESPONSE REGULATOR receiver
HC362_RS11860	COG2205	protein histidine kinase activity
HC362_RS11885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HC362_RS11895	COG4106	trans-aconitate 2-methyltransferase activity
HC362_RS11900	COG0583	DNA-binding transcription factor activity
HC362_RS11905	COG2814	Major facilitator Superfamily
HC362_RS11910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS11925	COG1079	Belongs to the binding-protein-dependent transport system permease family
HC362_RS11930	COG4603	Belongs to the binding-protein-dependent transport system permease family
HC362_RS11935	COG3845	ABC transporter
HC362_RS11945	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HC362_RS11945	COG1473	amidohydrolase
HC362_RS11950	COG1733	regulation of RNA biosynthetic process
HC362_RS11980	COG2089	acid synthase
HC362_RS11995	COG1216	Glycosyl transferase, family 2
HC362_RS12010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HC362_RS12010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HC362_RS12025	COG1595	DNA-templated transcription, initiation
HC362_RS12035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HC362_RS12045	COG2009	succinate dehydrogenase
HC362_RS12055	COG1053	succinate dehydrogenase
HC362_RS12065	COG2801	Transposase and inactivated derivatives
HC362_RS12065	COG3415	Transposase
HC362_RS12070	COG0657	acetylesterase activity
HC362_RS12080	COG1408	metallophosphoesterase
HC362_RS12105	COG0180	Tryptophanyl-tRNA synthetase
HC362_RS12110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC362_RS12115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC362_RS12135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC362_RS12140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC362_RS12160	COG4176	ABC-type proline glycine betaine transport system permease component
HC362_RS12165	COG0517	IMP dehydrogenase activity
HC362_RS12165	COG4175	Glycine betaine
HC362_RS12175	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS12210	COG1846	Transcriptional regulator
HC362_RS12215	COG0039	L-malate dehydrogenase activity
HC362_RS12230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC362_RS12245	COG0138	bifunctional purine biosynthesis protein purh
HC362_RS12275	COG0045	succinate-CoA ligase (ADP-forming) activity
HC362_RS12280	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HC362_RS12285	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HC362_RS12290	COG0714	Associated with various cellular activities
HC362_RS12305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HC362_RS12325	COG0791	NLP P60 protein
HC362_RS12355	COG2197	response regulator
HC362_RS12370	COG1476	TRANSCRIPTIONal
HC362_RS12395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC362_RS12395	COG0519	Catalyzes the synthesis of GMP from XMP
HC362_RS12400	COG0077	Prephenate dehydratase
HC362_RS12400	COG1605	Chorismate mutase
HC362_RS12410	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS12425	COG0515	serine threonine protein kinase
HC362_RS12425	COG2815	serine threonine protein kinase
HC362_RS12430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC362_RS12440	COG0516	GMP reductase activity
HC362_RS12450	COG1595	DNA-templated transcription, initiation
HC362_RS12475	COG4221	oxidoreductase activity
HC362_RS12485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HC362_RS12510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC362_RS12520	COG0456	acetyltransferase
HC362_RS12520	COG1214	PFAM Peptidase M22, glycoprotease
HC362_RS12540	COG0802	atpase or kinase
HC362_RS12550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC362_RS12555	COG2318	DinB family
HC362_RS12570	COG0736	holo-[acyl-carrier-protein] synthase activity
HC362_RS12580	COG1072	(Pantothenic acid kinase))
HC362_RS12585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC362_RS12590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HC362_RS12595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC362_RS12605	COG0101	tRNA pseudouridine synthase activity
HC362_RS12610	COG0203	ribosomal protein L17
HC362_RS12615	COG0202	RNA polymerase activity
HC362_RS12620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC362_RS12625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC362_RS12630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC362_RS12635	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC362_RS12640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HC362_RS12650	COG0563	adenylate kinase activity
HC362_RS12660	COG0200	Binds to the 23S rRNA
HC362_RS12665	COG1841	ribosomal large subunit assembly
HC362_RS12670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HC362_RS12675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC362_RS12680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC362_RS12685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC362_RS12690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC362_RS12695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC362_RS12700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HC362_RS12705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC362_RS12710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC362_RS12715	COG0255	Belongs to the universal ribosomal protein uL29 family
HC362_RS12720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC362_RS12725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HC362_RS12730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HC362_RS12735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HC362_RS12740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC362_RS12745	COG0089	rRNA binding
HC362_RS12750	COG0088	Forms part of the polypeptide exit tunnel
HC362_RS12755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC362_RS12760	COG0051	transcription antitermination factor activity, RNA binding
HC362_RS12875	COG2070	2-Nitropropane dioxygenase
HC362_RS12880	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC362_RS12885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC362_RS12890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC362_RS12895	COG0049	tRNA binding
HC362_RS12900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC362_RS12910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC362_RS12915	COG0085	RNA polymerase activity
HC362_RS12920	COG0222	ribosome binding
HC362_RS12925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC362_RS12935	COG0081	regulation of translation
HC362_RS12940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HC362_RS12945	COG0250	Participates in transcription elongation, termination and antitermination
HC362_RS12960	COG0436	Aminotransferase
HC362_RS12965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HC362_RS12980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC362_RS12990	COG2030	dehydratase
HC362_RS12995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HC362_RS13015	COG0702	epimerase
HC362_RS13025	COG1666	GTP binding
HC362_RS13030	COG3304	Inner membrane component domain
HC362_RS13035	COG0501	Belongs to the peptidase M48B family
HC362_RS13040	COG1007	ATP synthesis coupled electron transport
HC362_RS13050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC362_RS13055	COG0713	ATP synthesis coupled electron transport
HC362_RS13060	COG0839	Belongs to the complex I subunit 6 family
HC362_RS13065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS13070	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HC362_RS13075	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS13080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS13085	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS13090	COG0674	pyruvate-flavodoxin oxidoreductase activity
HC362_RS13090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HC362_RS13095	COG1013	pyruvate-flavodoxin oxidoreductase activity
HC362_RS13120	COG0142	geranyltranstransferase activity
HC362_RS13125	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC362_RS13150	COG1007	ATP synthesis coupled electron transport
HC362_RS13160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC362_RS13165	COG0713	ATP synthesis coupled electron transport
HC362_RS13170	COG0839	Belongs to the complex I subunit 6 family
HC362_RS13175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS13180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HC362_RS13185	COG1034	ATP synthesis coupled electron transport
HC362_RS13190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HC362_RS13200	COG0649	NAD binding
HC362_RS13205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS13210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC362_RS13235	COG2226	methyltransferase
HC362_RS13240	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HC362_RS13245	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HC362_RS13250	COG1278	Cold shock
HC362_RS13255	COG0698	ribose 5-phosphate isomerase
HC362_RS13260	COG2376	Dihydroxyacetone kinase
HC362_RS13265	COG1070	Carbohydrate kinase
HC362_RS13275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC362_RS13285	COG2814	Major facilitator Superfamily
HC362_RS13295	COG2378	regulation of single-species biofilm formation
HC362_RS13300	COG2197	response regulator
HC362_RS13320	COG3246	L-lysine catabolic process to acetate
HC362_RS13325	COG3415	Transposase
HC362_RS13325	COG2801	Transposase and inactivated derivatives
HC362_RS13330	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC362_RS13340	COG2175	clavaminate synthase activity
HC362_RS13365	COG1301	dicarboxylic acid transport
HC362_RS13375	COG1573	uracil-dna glycosylase
HC362_RS13380	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HC362_RS13390	COG0163	prenyltransferase activity
HC362_RS13415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC362_RS13430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC362_RS13435	COG1333	cytochrome c biogenesis protein
HC362_RS13445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC362_RS13450	COG0406	alpha-ribazole phosphatase activity
HC362_RS13455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC362_RS13465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC362_RS13485	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HC362_RS13490	COG0018	arginyl-trna synthetase
HC362_RS13510	COG2018	Roadblock/LC7 domain
HC362_RS13525	COG0113	porphobilinogen synthase activity
HC362_RS13530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC362_RS13530	COG1648	precorrin-2 dehydrogenase activity
HC362_RS13535	COG0181	hydroxymethylbilane synthase activity
HC362_RS13540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC362_RS13545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC362_RS13590	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC362_RS13610	COG4585	Histidine kinase
HC362_RS13620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC362_RS13630	COG0842	Transport permease protein
HC362_RS13630	COG1129	ABC transporter
HC362_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS13650	COG2409	Drug exporters of the RND superfamily
HC362_RS13670	COG0129	dihydroxy-acid dehydratase activity
HC362_RS13680	COG1082	Xylose isomerase domain protein TIM barrel
HC362_RS13685	COG0248	Ppx GppA phosphatase
HC362_RS13705	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC362_RS13725	COG1309	transcriptional regulator
HC362_RS13730	COG0739	heme binding
HC362_RS13755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC362_RS13775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC362_RS13780	COG0157	Belongs to the NadC ModD family
HC362_RS13785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC362_RS13790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC362_RS13800	COG0640	Transcriptional regulator
HC362_RS13805	COG2197	response regulator
HC362_RS13820	COG1125	glycine betaine transport
HC362_RS13820	COG0517	IMP dehydrogenase activity
HC362_RS13830	COG1174	glycine betaine transport
HC362_RS13835	COG1732	Glycine betaine
HC362_RS13845	COG0649	NAD binding
HC362_RS13870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC362_RS13875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC362_RS13885	COG0302	gtp cyclohydrolase
HC362_RS13900	COG0037	tRNA processing
HC362_RS13910	COG2027	D-alanyl-D-alanine carboxypeptidase
HC362_RS13915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HC362_RS13925	COG0789	Transcriptional regulator
HC362_RS13935	COG2318	DinB family
HC362_RS13940	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS13965	COG1132	(ABC) transporter
HC362_RS13985	COG1846	Transcriptional regulator
HC362_RS14005	COG3415	Transposase
HC362_RS14005	COG2801	Transposase and inactivated derivatives
HC362_RS14010	COG4565	transcriptional regulatory protein
HC362_RS14015	COG3290	protein histidine kinase activity
HC362_RS14020	COG2851	Citrate transporter
HC362_RS14055	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HC362_RS14120	COG2188	Transcriptional regulator
HC362_RS14150	COG1201	RNA secondary structure unwinding
HC362_RS14170	COG2226	methyltransferase
HC362_RS14175	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HC362_RS14210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC362_RS14215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC362_RS14215	COG1754	DNA topoisomerase type I activity
HC362_RS14230	COG2264	protein methyltransferase activity
HC362_RS14240	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HC362_RS14245	COG2172	sigma factor antagonist activity
HC362_RS14250	COG1366	Belongs to the anti-sigma-factor antagonist family
HC362_RS14255	COG1111	helicase
HC362_RS14255	COG1205	dead DEAH box helicase
HC362_RS14425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC362_RS14430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HC362_RS14440	COG2267	carboxylic ester hydrolase activity
HC362_RS14470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC362_RS14495	COG0003	Pfam Anion-transporting ATPase
HC362_RS14505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC362_RS14510	COG1610	YqeY-like protein
HC362_RS14515	COG1408	metallophosphoesterase
HC362_RS14560	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC362_RS14580	COG0222	ribosome binding
HC362_RS14605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC362_RS14605	COG0515	serine threonine protein kinase
HC362_RS14610	COG2124	cytochrome p450
HC362_RS14625	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HC362_RS14655	COG1595	DNA-templated transcription, initiation
HC362_RS14675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC362_RS14680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC362_RS14700	COG3594	Acyltransferase
HC362_RS14720	COG1253	flavin adenine dinucleotide binding
HC362_RS14740	COG1316	TRANSCRIPTIONal
HC362_RS14770	COG1595	DNA-templated transcription, initiation
HC362_RS14780	COG0531	amino acid
HC362_RS14805	COG0659	secondary active sulfate transmembrane transporter activity
HC362_RS14830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HC362_RS14835	COG0640	Transcriptional regulator
HC362_RS14850	COG2197	response regulator
HC362_RS14860	COG0671	phosphoesterase, PA-phosphatase related
HC362_RS14890	COG3290	protein histidine kinase activity
HC362_RS14900	COG2261	transglycosylase associated protein
HC362_RS14910	COG3795	YCII-related domain
HC362_RS14915	COG4941	Belongs to the sigma-70 factor family
HC362_RS14925	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HC362_RS14930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HC362_RS14935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HC362_RS14955	COG1051	belongs to the nudix hydrolase family
HC362_RS14980	COG0326	Molecular chaperone. Has ATPase activity
HC362_RS15025	COG0513	Belongs to the DEAD box helicase family
HC362_RS15050	COG0582	viral genome integration into host DNA
HC362_RS15090	COG0640	Transcriptional regulator
HC362_RS15095	COG0798	PFAM Bile acid sodium symporter
HC362_RS15100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC362_RS15145	COG1484	DNA-dependent DNA replication
HC362_RS15175	COG3883	PFAM NLP P60 protein
HC362_RS15175	COG0791	NLP P60 protein
HC362_RS15285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC362_RS15410	COG1309	transcriptional regulator
HC362_RS15425	COG0667	Aldo Keto reductase
HC362_RS15440	COG3842	ATPase activity
HC362_RS15445	COG4149	molybdate abc transporter
HC362_RS15455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC362_RS15465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HC362_RS15495	COG0785	Cytochrome C biogenesis protein
HC362_RS15500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC362_RS15500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HC362_RS15515	COG2949	membrane
HC362_RS15520	COG1643	Atp-dependent helicase
HC362_RS15545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC362_RS15555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC362_RS15570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC362_RS15575	COG0047	phosphoribosylformylglycinamidine synthase activity
HC362_RS15580	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC362_RS15615	COG1131	(ABC) transporter
HC362_RS15630	COG2197	response regulator
HC362_RS15640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC362_RS15650	COG0596	Alpha beta hydrolase
HC362_RS15665	COG0151	Belongs to the GarS family
HC362_RS15680	COG1802	Transcriptional regulator
HC362_RS15690	COG1280	lysine exporter protein (LysE YggA)
HC362_RS15695	COG1522	sequence-specific DNA binding
HC362_RS15700	COG0693	protein deglycase activity
HC362_RS15710	COG3559	Exporter of polyketide antibiotics
HC362_RS15715	COG1131	(ABC) transporter
HC362_RS15730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HC362_RS15760	COG3483	tryptophan 2,3-dioxygenase activity
HC362_RS15770	COG2364	Membrane
HC362_RS15785	COG3844	kynureninase activity
HC362_RS15790	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS15800	COG0191	fructose-bisphosphate aldolase activity
HC362_RS15805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC362_RS15820	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC362_RS15845	COG0542	response to heat
HC362_RS15855	COG0789	Transcriptional regulator
HC362_RS15860	COG0484	heat shock protein binding
HC362_RS15865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC362_RS15870	COG0443	Heat shock 70 kDa protein
HC362_RS15875	COG0247	lactate metabolic process
HC362_RS15875	COG2181	nitrate reductase activity
HC362_RS15900	COG0717	Belongs to the dCTP deaminase family
HC362_RS15960	COG0590	tRNA wobble adenosine to inosine editing
HC362_RS15995	COG0667	Aldo Keto reductase
HC362_RS16000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC362_RS16020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC362_RS16025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC362_RS16030	COG2080	2 iron, 2 sulfur cluster binding
HC362_RS16075	COG2186	Transcriptional regulator
HC362_RS16080	COG3265	gluconokinase activity
HC362_RS16105	COG1136	(ABC) transporter
HC362_RS16105	COG0577	efflux transmembrane transporter activity
HC362_RS16110	COG0598	Magnesium transport protein CorA
HC362_RS16130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC362_RS16140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC362_RS16155	COG1960	acyl-CoA dehydrogenase activity
HC362_RS16160	COG1362	aminopeptidase activity
HC362_RS16195	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC362_RS16200	COG0022	dehydrogenase e1 component
HC362_RS16220	COG0515	serine threonine protein kinase
HC362_RS16225	COG0515	serine threonine protein kinase
HC362_RS16235	COG1309	transcriptional regulator
HC362_RS16240	COG1522	sequence-specific DNA binding
HC362_RS16270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC362_RS16280	COG0604	alcohol dehydrogenase
HC362_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS16280	COG3321	synthase
HC362_RS16310	COG3396	Phenylacetate-CoA oxygenase
HC362_RS16315	COG3460	Phenylacetate-CoA oxygenase
HC362_RS16320	COG3396	Phenylacetate-CoA oxygenase
HC362_RS16325	COG2151	metal-sulfur cluster biosynthetic enzyme
HC362_RS16330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC362_RS16335	COG1960	acyl-CoA dehydrogenase activity
HC362_RS16350	COG1733	regulation of RNA biosynthetic process
HC362_RS16355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC362_RS16365	COG1716	ATPase activity
HC362_RS16370	COG1716	ATPase activity
HC362_RS16380	COG0772	Belongs to the SEDS family
HC362_RS16385	COG0768	penicillin binding
HC362_RS16390	COG0515	serine threonine protein kinase
HC362_RS16395	COG3764	Sortase (surface protein transpeptidase)
HC362_RS16400	COG3764	Sortase (surface protein transpeptidase)
HC362_RS16405	COG0512	Glutamine amidotransferase of anthranilate synthase
HC362_RS16415	COG3764	Sortase (surface protein transpeptidase)
HC362_RS16430	COG0705	Rhomboid family
HC362_RS16455	COG1595	DNA-templated transcription, initiation
HC362_RS16475	COG0515	serine threonine protein kinase
HC362_RS16495	COG1295	ribonuclease BN
HC362_RS16515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC362_RS16525	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HC362_RS16530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC362_RS16535	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HC362_RS16540	COG0592	DNA-directed DNA polymerase activity
HC362_RS16545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC362_RS16550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HC362_RS16555	COG0594	ribonuclease P activity
HC362_RS16560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC362_RS16565	COG0706	membrane insertase activity
HC362_RS16575	COG0357	Ribosomal RNA small subunit methyltransferase G
HC362_RS16580	COG1192	Involved in chromosome partitioning
HC362_RS16595	COG3118	belongs to the thioredoxin family
HC362_RS16600	COG0492	ferredoxin-NADP+ reductase activity
HC362_RS16630	COG0617	tRNA 3'-terminal CCA addition
HC362_RS16645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC362_RS16675	COG0360	Binds together with S18 to 16S ribosomal RNA
HC362_RS16680	COG0629	single-stranded DNA binding
HC362_RS16685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC362_RS16690	COG0359	binds to the 23S rRNA
HC362_RS16695	COG0534	Mate efflux family protein
HC362_RS16740	COG0596	Alpha beta hydrolase
HC362_RS16755	COG1846	Transcriptional regulator
HC362_RS16785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC362_RS16800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC362_RS16815	COG0662	Cupin 2, conserved barrel domain protein
HC362_RS16820	COG1950	PFAM Membrane protein of
HC362_RS16825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC362_RS16835	COG0626	cystathionine gamma-synthase activity
HC362_RS16845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC362_RS16850	COG1609	Transcriptional regulator
HC362_RS16855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC362_RS16860	COG1271	oxidase subunit
HC362_RS16865	COG1294	oxidase, subunit
HC362_RS16870	COG4988	ABC transporter
HC362_RS16890	COG0561	phosphatase activity
HC362_RS16895	COG0501	Belongs to the peptidase M48B family
HC362_RS16910	COG1393	Belongs to the ArsC family
HC362_RS16915	COG0535	radical SAM domain protein
HC362_RS16945	COG0789	Transcriptional regulator
HC362_RS16960	COG1131	(ABC) transporter
HC362_RS16970	COG1131	(ABC) transporter
HC362_RS16995	COG2378	regulation of single-species biofilm formation
HC362_RS17010	COG0561	phosphatase activity
HC362_RS17015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC362_RS17025	COG2837	iron assimilation
HC362_RS17030	COG2372	response to copper ion
HC362_RS17040	COG1999	signal sequence binding
HC362_RS17060	COG2770	Histidine kinase
HC362_RS17060	COG2208	phosphoserine phosphatase activity
HC362_RS17065	COG0006	proline dipeptidase activity
HC362_RS17085	COG0653	protein targeting
HC362_RS17100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC362_RS17145	COG1595	DNA-templated transcription, initiation
HC362_RS17150	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS17175	COG0582	viral genome integration into host DNA
HC362_RS17205	COG2188	Transcriptional regulator
HC362_RS17220	COG0494	nUDIX hydrolase
HC362_RS17260	COG0477	Major facilitator Superfamily
HC362_RS17265	COG1846	Transcriptional regulator
HC362_RS17280	COG1191	sigma factor activity
HC362_RS17295	COG1063	alcohol dehydrogenase
HC362_RS17300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC362_RS17310	COG0590	tRNA wobble adenosine to inosine editing
HC362_RS17320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC362_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS17370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC362_RS17405	COG0745	RESPONSE REGULATOR receiver
HC362_RS17410	COG5002	protein histidine kinase activity
HC362_RS17425	COG0667	Aldo Keto reductase
HC362_RS17430	COG0702	epimerase
HC362_RS17435	COG1595	DNA-templated transcription, initiation
HC362_RS17455	COG1196	nuclear chromosome segregation
HC362_RS17455	COG0739	heme binding
HC362_RS17455	COG0741	lytic transglycosylase activity
HC362_RS17460	COG0667	Aldo Keto reductase
HC362_RS17465	COG3467	pyridoxamine 5'-phosphate
HC362_RS17505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC362_RS17515	COG0579	oxidoreductase
HC362_RS17560	COG1846	Transcriptional regulator
HC362_RS17620	COG0739	heme binding
HC362_RS17620	COG1196	nuclear chromosome segregation
HC362_RS17620	COG0741	lytic transglycosylase activity
HC362_RS17625	COG0671	phosphoesterase, PA-phosphatase related
HC362_RS17645	COG1937	Protein conserved in bacteria
HC362_RS17655	COG0306	phosphate transporter
HC362_RS17660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC362_RS17705	COG1733	regulation of RNA biosynthetic process
HC362_RS17720	COG1902	pentaerythritol trinitrate reductase activity
HC362_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS17740	COG0488	(ABC) transporter
HC362_RS17745	COG4257	antibiotic catabolic process
HC362_RS17750	COG2226	methyltransferase
HC362_RS17775	COG2188	Transcriptional regulator
HC362_RS17785	COG4552	Acetyltransferase involved in intracellular survival and related
HC362_RS17800	COG1490	D-aminoacyl-tRNA deacylase activity
HC362_RS17805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC362_RS17810	COG0735	belongs to the Fur family
HC362_RS17820	COG3485	protocatechuate 3,4-dioxygenase
HC362_RS17835	COG2897	thiosulfate sulfurtransferase activity
HC362_RS17860	COG0745	RESPONSE REGULATOR receiver
HC362_RS17865	COG1609	Transcriptional regulator
HC362_RS17875	COG0745	RESPONSE REGULATOR receiver
HC362_RS17885	COG0456	acetyltransferase
HC362_RS17895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HC362_RS17910	COG0438	transferase activity, transferring glycosyl groups
HC362_RS17975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC362_RS17995	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS18010	COG0588	phosphoglycerate mutase activity
HC362_RS18035	COG5002	protein histidine kinase activity
HC362_RS18050	COG1329	Transcriptional regulator
HC362_RS18055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC362_RS18060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC362_RS18065	COG3467	pyridoxamine 5'-phosphate
HC362_RS18070	COG0215	cysteine-tRNA ligase activity
HC362_RS18085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC362_RS18095	COG3842	ATPase activity
HC362_RS18180	COG1105	Belongs to the carbohydrate kinase PfkB family
HC362_RS18185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC362_RS18195	COG1653	transport
HC362_RS18215	COG0463	Glycosyl transferase, family 2
HC362_RS18230	COG1278	Cold shock
HC362_RS18285	COG1309	transcriptional regulator
HC362_RS18300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC362_RS18305	COG1737	Transcriptional regulator
HC362_RS18330	COG3142	Participates in the control of copper homeostasis
HC362_RS18335	COG2814	Major facilitator Superfamily
HC362_RS18340	COG0640	Transcriptional regulator
HC362_RS18345	COG3347	Dehydrogenase
HC362_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS18360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC362_RS18365	COG3973	AAA domain
HC362_RS18370	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS18375	COG1061	Type III restriction enzyme res subunit
HC362_RS18395	COG1802	Transcriptional regulator
HC362_RS18440	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HC362_RS18445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC362_RS18455	COG2814	Major facilitator Superfamily
HC362_RS18480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC362_RS18490	COG2252	PERMEase
HC362_RS18500	COG1846	Transcriptional regulator
HC362_RS18515	COG0667	Aldo Keto reductase
HC362_RS18560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC362_RS18570	COG0277	FAD linked oxidase domain protein
HC362_RS18590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC362_RS18605	COG1024	Enoyl-CoA hydratase
HC362_RS18655	COG0259	pyridoxamine-phosphate oxidase activity
HC362_RS18665	COG4821	SIS domain
HC362_RS18675	COG2945	thiolester hydrolase activity
HC362_RS18675	COG0596	Alpha beta hydrolase
HC362_RS18720	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS18730	COG1960	acyl-CoA dehydrogenase activity
HC362_RS18735	COG1960	acyl-CoA dehydrogenase activity
HC362_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS18755	COG1960	acyl-CoA dehydrogenase activity
HC362_RS18760	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS18765	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HC362_RS18770	COG4977	sequence-specific DNA binding
HC362_RS18795	COG1024	Enoyl-CoA hydratase
HC362_RS18805	COG2072	flavoprotein involved in K transport
HC362_RS18825	COG1960	acyl-CoA dehydrogenase activity
HC362_RS18835	COG1309	transcriptional regulator
HC362_RS18840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC362_RS18840	COG0515	serine threonine protein kinase
HC362_RS18895	COG2124	cytochrome p450
HC362_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS18945	COG0667	Aldo Keto reductase
HC362_RS18960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HC362_RS18980	COG0583	DNA-binding transcription factor activity
HC362_RS19010	COG1686	Belongs to the peptidase S11 family
HC362_RS19030	COG0702	epimerase
HC362_RS19070	COG0789	Transcriptional regulator
HC362_RS19075	COG5504	Zn-dependent protease
HC362_RS19085	COG1472	Belongs to the glycosyl hydrolase 3 family
HC362_RS19090	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC362_RS19110	COG1349	DNA-binding transcription factor activity
HC362_RS19120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC362_RS19120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC362_RS19120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC362_RS19125	COG3191	aminopeptidase activity
HC362_RS19135	COG1970	mechanosensitive ion channel activity
HC362_RS19145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC362_RS19160	COG3263	regulation of cellular component size
HC362_RS19170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC362_RS19175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC362_RS19185	COG0315	cyclic pyranopterin monophosphate synthase activity
HC362_RS19190	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC362_RS19195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC362_RS19210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC362_RS19215	COG3634	alkyl hydroperoxide reductase activity
HC362_RS19230	COG0583	DNA-binding transcription factor activity
HC362_RS19245	COG0789	Transcriptional regulator
HC362_RS19260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC362_RS19315	COG2188	Transcriptional regulator
HC362_RS19480	COG0629	single-stranded DNA binding
HC362_RS19560	COG0708	Exodeoxyribonuclease III
HC362_RS19580	COG2072	flavoprotein involved in K transport
HC362_RS19585	COG2267	carboxylic ester hydrolase activity
HC362_RS19590	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS19600	COG4946	Tricorn protease homolog
HC362_RS19600	COG0793	Belongs to the peptidase S41A family
HC362_RS19605	COG2409	Drug exporters of the RND superfamily
HC362_RS19615	COG0310	cobalt ion transport
HC362_RS19625	COG1122	ATPase activity
HC362_RS19635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC362_RS19640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC362_RS19645	COG0084	hydrolase, TatD family'
HC362_RS19675	COG0488	(ABC) transporter
HC362_RS19715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC362_RS19720	COG2197	response regulator
HC362_RS19740	COG4106	trans-aconitate 2-methyltransferase activity
HC362_RS19745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC362_RS19750	COG1309	transcriptional regulator
HC362_RS19760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HC362_RS19780	COG2409	Drug exporters of the RND superfamily
HC362_RS19785	COG2323	membrane
HC362_RS19790	COG0193	aminoacyl-tRNA hydrolase activity
HC362_RS19795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC362_RS19800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC362_RS19805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC362_RS19820	COG4585	Histidine kinase
HC362_RS19850	COG1316	TRANSCRIPTIONal
HC362_RS19885	COG0515	serine threonine protein kinase
HC362_RS19930	COG0148	phosphopyruvate hydratase activity
HC362_RS19940	COG2124	cytochrome p450
HC362_RS19955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC362_RS19960	COG0577	efflux transmembrane transporter activity
HC362_RS19965	COG1136	(ABC) transporter
HC362_RS19985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC362_RS19995	COG2259	Doxx family
HC362_RS20020	COG0183	Belongs to the thiolase family
HC362_RS20025	COG2755	lipolytic protein G-D-S-L family
HC362_RS20065	COG0667	Aldo Keto reductase
HC362_RS20075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC362_RS20090	COG1228	amidohydrolase
HC362_RS20100	COG1191	sigma factor activity
HC362_RS20105	COG1366	Belongs to the anti-sigma-factor antagonist family
HC362_RS20130	COG3104	oligopeptide transport
HC362_RS20135	COG0745	RESPONSE REGULATOR receiver
HC362_RS20140	COG2205	protein histidine kinase activity
HC362_RS20155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC362_RS20165	COG0402	S-adenosylhomocysteine deaminase activity
HC362_RS20175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC362_RS20190	COG1316	TRANSCRIPTIONal
HC362_RS20200	COG1316	TRANSCRIPTIONal
HC362_RS20220	COG1316	TRANSCRIPTIONal
HC362_RS20245	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HC362_RS20245	COG0778	Nitroreductase
HC362_RS20250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC362_RS20285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC362_RS20290	COG2835	tetraacyldisaccharide 4'-kinase activity
HC362_RS20300	COG1482	cell wall glycoprotein biosynthetic process
HC362_RS20310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC362_RS20310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC362_RS20310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC362_RS20315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HC362_RS20355	COG0714	Associated with various cellular activities
HC362_RS20375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC362_RS20380	COG0745	RESPONSE REGULATOR receiver
HC362_RS20385	COG5000	phosphorelay sensor kinase activity
HC362_RS20385	COG5002	protein histidine kinase activity
HC362_RS20390	COG0823	Involved in the tonB-independent uptake of proteins
HC362_RS20400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC362_RS20405	COG2197	response regulator
HC362_RS20410	COG3214	Protein conserved in bacteria
HC362_RS20420	COG0653	protein targeting
HC362_RS20455	COG0438	transferase activity, transferring glycosyl groups
HC362_RS20460	COG3594	Acyltransferase
HC362_RS20465	COG3594	Acyltransferase
HC362_RS20495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC362_RS20500	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC362_RS20510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC362_RS20535	COG1216	Glycosyl transferase, family 2
HC362_RS20540	COG1595	DNA-templated transcription, initiation
HC362_RS20580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC362_RS20585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC362_RS20590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC362_RS20610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HC362_RS20620	COG0395	ABC-type sugar transport system, permease component
HC362_RS20625	COG1175	transmembrane transport
HC362_RS20630	COG1653	transport
HC362_RS20640	COG0515	serine threonine protein kinase
HC362_RS20645	COG0515	serine threonine protein kinase
HC362_RS20660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC362_RS20675	COG2884	Cell division ATP-binding protein ftsE
HC362_RS20680	COG2177	Part of the ABC transporter FtsEX involved in
HC362_RS20685	COG0793	Belongs to the peptidase S41A family
HC362_RS20690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC362_RS20710	COG0583	DNA-binding transcription factor activity
HC362_RS20720	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS20725	COG1309	transcriptional regulator
HC362_RS20730	COG1881	PFAM PEBP family protein
HC362_RS20785	COG3973	AAA domain
HC362_RS20790	COG1278	Cold shock
HC362_RS20800	COG0776	regulation of translation
HC362_RS20825	COG1178	ABC-type Fe3 transport system permease component
HC362_RS20830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HC362_RS20835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HC362_RS20840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC362_RS20875	COG0531	amino acid
HC362_RS20880	COG2362	D-Aminopeptidase
HC362_RS20890	COG3321	synthase
HC362_RS20890	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS20890	COG0604	alcohol dehydrogenase
HC362_RS20915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HC362_RS20930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC362_RS20955	COG2855	membrane
HC362_RS20965	COG0583	DNA-binding transcription factor activity
HC362_RS21010	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HC362_RS21015	COG2801	Transposase and inactivated derivatives
HC362_RS21015	COG3415	Transposase
HC362_RS21020	COG0277	FAD linked oxidase domain protein
HC362_RS21055	COG1335	isochorismatase
HC362_RS21065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HC362_RS21075	COG1113	amino acid transport
HC362_RS21100	COG1234	tRNA 3'-trailer cleavage
HC362_RS21105	COG1263	PTS System
HC362_RS21110	COG1263	PTS System
HC362_RS21115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC362_RS21120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC362_RS21130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC362_RS21155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HC362_RS21175	COG1131	(ABC) transporter
HC362_RS21185	COG2733	membrane
HC362_RS21190	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC362_RS21195	COG0515	serine threonine protein kinase
HC362_RS21195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC362_RS21200	COG0673	inositol 2-dehydrogenase activity
HC362_RS21240	COG2186	Transcriptional regulator
HC362_RS21265	COG1126	abc transporter atp-binding protein
HC362_RS21270	COG0765	amino acid transport
HC362_RS21275	COG0765	amino acid transport
HC362_RS21280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC362_RS21290	COG0154	amidase activity
HC362_RS21305	COG3473	Maleate cis-trans isomerase
HC362_RS21310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS21360	COG0588	phosphoglycerate mutase activity
HC362_RS21390	COG0745	RESPONSE REGULATOR receiver
HC362_RS21430	COG0025	NhaP-type Na H and K H
HC362_RS21440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HC362_RS21445	COG4977	sequence-specific DNA binding
HC362_RS21450	COG0589	response to stress
HC362_RS21455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC362_RS21475	COG1960	acyl-CoA dehydrogenase activity
HC362_RS21490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC362_RS21495	COG1309	transcriptional regulator
HC362_RS21505	COG1946	Acyl-CoA thioesterase
HC362_RS21530	COG1051	belongs to the nudix hydrolase family
HC362_RS21545	COG1609	Transcriptional regulator
HC362_RS21550	COG0673	inositol 2-dehydrogenase activity
HC362_RS21565	COG1869	D-ribose catabolic process
HC362_RS21570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS21580	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC362_RS21585	COG1129	ABC transporter
HC362_RS21590	COG1609	Transcriptional regulator
HC362_RS21595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC362_RS21635	COG3718	enzyme involved in inositol metabolism
HC362_RS21640	COG3962	Belongs to the TPP enzyme family
HC362_RS21650	COG1289	transmembrane transporter activity
HC362_RS21700	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS21795	COG2356	endonuclease I
HC362_RS21800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC362_RS21805	COG1993	acr, cog1993
HC362_RS21810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC362_RS21840	COG2208	phosphoserine phosphatase activity
HC362_RS21840	COG2770	Histidine kinase
HC362_RS21850	COG0038	chloride channel
HC362_RS21885	COG0693	protein deglycase activity
HC362_RS21900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC362_RS21900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HC362_RS21905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HC362_RS21910	COG0438	transferase activity, transferring glycosyl groups
HC362_RS21925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HC362_RS21935	COG2192	nodulation
HC362_RS21940	COG1088	dTDP-glucose 4,6-dehydratase activity
HC362_RS22010	COG0629	single-stranded DNA binding
HC362_RS22035	COG2346	COG2346, Truncated hemoglobins
HC362_RS22040	COG0842	Transport permease protein
HC362_RS22055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC362_RS22085	COG0668	transmembrane transport
HC362_RS22095	COG3291	Pkd domain containing protein
HC362_RS22095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HC362_RS22150	COG0583	DNA-binding transcription factor activity
HC362_RS22160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC362_RS22165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC362_RS22170	COG1215	transferase activity, transferring glycosyl groups
HC362_RS22175	COG1316	TRANSCRIPTIONal
HC362_RS22180	COG1113	amino acid transport
HC362_RS22190	COG1113	amino acid transport
HC362_RS22205	COG4552	Acetyltransferase involved in intracellular survival and related
HC362_RS22215	COG3594	Acyltransferase
HC362_RS22235	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC362_RS22240	COG0740	serine-type endopeptidase activity
HC362_RS22245	COG0740	serine-type endopeptidase activity
HC362_RS22250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC362_RS22270	COG0525	valine-tRNA ligase activity
HC362_RS22275	COG0285	dihydrofolate synthase activity
HC362_RS22285	COG0105	UTP biosynthetic process
HC362_RS22290	COG1077	Cell shape determining protein MreB Mrl
HC362_RS22305	COG0768	penicillin binding
HC362_RS22310	COG0772	Belongs to the SEDS family
HC362_RS22330	COG1530	ribonuclease E activity
HC362_RS22335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC362_RS22340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC362_RS22345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC362_RS22360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC362_RS22370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC362_RS22385	COG0501	Belongs to the peptidase M48B family
HC362_RS22395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC362_RS22410	COG0588	phosphoglycerate mutase activity
HC362_RS22425	COG0477	Major facilitator Superfamily
HC362_RS22445	COG0495	leucyl-tRNA aminoacylation
HC362_RS22455	COG1307	EDD domain protein, DegV family
HC362_RS22480	COG0268	Binds directly to 16S ribosomal RNA
HC362_RS22485	COG0481	GTPase activity
HC362_RS22495	COG0745	RESPONSE REGULATOR receiver
HC362_RS22520	COG1420	regulation of RNA biosynthetic process
HC362_RS22525	COG0484	heat shock protein binding
HC362_RS22530	COG2070	2-Nitropropane dioxygenase
HC362_RS22540	COG0537	adenosine 5'-monophosphoramidase activity
HC362_RS22545	COG1234	tRNA 3'-trailer cleavage
HC362_RS22550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC362_RS22575	COG2315	Protein conserved in bacteria
HC362_RS22585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC362_RS22595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS22615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC362_RS22625	COG2723	6-phospho-beta-galactosidase activity
HC362_RS22645	COG1381	Involved in DNA repair and RecF pathway recombination
HC362_RS22650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC362_RS22665	COG1309	transcriptional regulator
HC362_RS22690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC362_RS22695	COG1121	(ABC) transporter
HC362_RS22705	COG0423	glycine-tRNA ligase activity
HC362_RS22710	COG2890	protein-(glutamine-N5) methyltransferase activity
HC362_RS22725	COG1902	pentaerythritol trinitrate reductase activity
HC362_RS22785	COG0477	Major facilitator Superfamily
HC362_RS22805	COG0574	Belongs to the PEP-utilizing enzyme family
HC362_RS22805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC362_RS22815	COG0789	Transcriptional regulator
HC362_RS22820	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS22825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC362_RS22860	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HC362_RS22870	COG0028	Belongs to the TPP enzyme family
HC362_RS22875	COG0358	DNA primase activity
HC362_RS22880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC362_RS22900	COG1070	Carbohydrate kinase
HC362_RS22915	COG0542	response to heat
HC362_RS22940	COG1793	dna ligase
HC362_RS22940	COG3285	dna ligase
HC362_RS22945	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC362_RS22965	COG2226	methyltransferase
HC362_RS22975	COG4981	capsule polysaccharide biosynthetic process
HC362_RS22985	COG0438	transferase activity, transferring glycosyl groups
HC362_RS23020	COG2130	NADP-dependent
HC362_RS23025	COG1764	response to oxidative stress
HC362_RS23045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC362_RS23050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC362_RS23055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS23080	COG0789	Transcriptional regulator
HC362_RS23095	COG2197	response regulator
HC362_RS23100	COG4585	Histidine kinase
HC362_RS23115	COG1309	transcriptional regulator
HC362_RS23120	COG0477	Major facilitator Superfamily
HC362_RS23130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HC362_RS23175	COG1358	cellular component organization or biogenesis
HC362_RS23200	COG3469	chitinase activity
HC362_RS23240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC362_RS23255	COG2124	cytochrome p450
HC362_RS23260	COG0183	Belongs to the thiolase family
HC362_RS23275	COG3845	ABC transporter
HC362_RS23320	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC362_RS23340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC362_RS23345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC362_RS23350	COG1984	allophanate hydrolase subunit 2
HC362_RS23355	COG1309	transcriptional regulator
HC362_RS23360	COG0438	transferase activity, transferring glycosyl groups
HC362_RS23375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS23385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC362_RS23390	COG3510	cephalosporin hydroxylase
HC362_RS23410	COG2030	dehydratase
HC362_RS23415	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HC362_RS23430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC362_RS23445	COG0800	Aldolase
HC362_RS23450	COG3022	response to hydroperoxide
HC362_RS23455	COG0277	FAD linked oxidase domain protein
HC362_RS23465	COG2318	DinB family
HC362_RS23510	COG0300	oxidoreductase activity
HC362_RS23515	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HC362_RS23530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS23535	COG3321	synthase
HC362_RS23535	COG0604	alcohol dehydrogenase
HC362_RS23545	COG2267	carboxylic ester hydrolase activity
HC362_RS23555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC362_RS23560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC362_RS23580	COG2197	response regulator
HC362_RS23585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS23605	COG2154	pterin-4-alpha-carbinolamine dehydratase
HC362_RS23650	COG2814	Major facilitator Superfamily
HC362_RS23665	COG1834	amidinotransferase
HC362_RS23705	COG0297	glycogen (starch) synthase activity
HC362_RS23710	COG0489	protein tyrosine kinase activity
HC362_RS23725	COG0438	transferase activity, transferring glycosyl groups
HC362_RS23730	COG0463	Glycosyl transferase, family 2
HC362_RS23745	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HC362_RS23750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC362_RS23755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC362_RS23770	COG0789	Transcriptional regulator
HC362_RS23775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC362_RS23795	COG1690	Belongs to the RtcB family
HC362_RS23845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC362_RS23850	COG0395	ABC-type sugar transport system, permease component
HC362_RS23855	COG1175	transmembrane transport
HC362_RS23870	COG2274	protein secretion by the type I secretion system
HC362_RS23920	COG1994	Peptidase M50
HC362_RS23955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC362_RS23960	COG0477	Major facilitator Superfamily
HC362_RS23975	COG2814	Major facilitator Superfamily
HC362_RS23985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC362_RS23985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC362_RS23990	COG2132	Multicopper oxidase
HC362_RS24015	COG2197	response regulator
HC362_RS24020	COG4585	Histidine kinase
HC362_RS24030	COG1725	Transcriptional regulator
HC362_RS24035	COG1131	(ABC) transporter
HC362_RS24065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC362_RS24105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS24110	COG0174	glutamine synthetase
HC362_RS24115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HC362_RS24130	COG0366	Alpha amylase catalytic
HC362_RS24140	COG1175	transmembrane transport
HC362_RS24150	COG0366	Alpha amylase catalytic
HC362_RS24170	COG4585	Histidine kinase
HC362_RS24180	COG2197	response regulator
HC362_RS24190	COG2890	protein-(glutamine-N5) methyltransferase activity
HC362_RS24210	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS24235	COG0321	lipoyl(octanoyl) transferase activity
HC362_RS24240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC362_RS24270	COG2226	methyltransferase
HC362_RS24290	COG2838	Isocitrate dehydrogenase
HC362_RS24310	COG3903	Transcriptional regulator
HC362_RS24310	COG3629	intracellular signal transduction
HC362_RS24330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HC362_RS24335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC362_RS24360	COG0697	spore germination
HC362_RS24370	COG1233	COG1233 Phytoene dehydrogenase and related
HC362_RS24405	COG0733	neurotransmitter:sodium symporter activity
HC362_RS24415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HC362_RS24440	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC362_RS24445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC362_RS24450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC362_RS24455	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HC362_RS24460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HC362_RS24475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC362_RS24495	COG4585	Histidine kinase
HC362_RS24500	COG2197	response regulator
HC362_RS24505	COG2801	Transposase and inactivated derivatives
HC362_RS24505	COG3415	Transposase
HC362_RS24510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS24530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC362_RS24545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC362_RS24550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC362_RS24560	COG1376	ErfK ybiS ycfS ynhG family protein
HC362_RS24570	COG1845	cytochrome c oxidase, subunit III
HC362_RS24575	COG2010	Cytochrome c
HC362_RS24580	COG0723	plastoquinol--plastocyanin reductase activity
HC362_RS24585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC362_RS24590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC362_RS24615	COG2223	nitrite transmembrane transporter activity
HC362_RS24620	COG0243	molybdopterin cofactor binding
HC362_RS24625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC362_RS24630	COG2146	nitrite reductase [NAD(P)H] activity
HC362_RS24630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC362_RS24650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC362_RS24705	COG1595	DNA-templated transcription, initiation
HC362_RS24710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC362_RS24715	COG1022	Amp-dependent synthetase and ligase
HC362_RS24730	COG0003	Pfam Anion-transporting ATPase
HC362_RS24740	COG1940	carbohydrate kinase activity
HC362_RS24770	COG2197	response regulator
HC362_RS24775	COG0205	6-phosphofructokinase activity
HC362_RS24785	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HC362_RS24795	COG2193	ferroxidase activity
HC362_RS24800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC362_RS24810	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC362_RS24820	COG0515	serine threonine protein kinase
HC362_RS24820	COG2815	serine threonine protein kinase
HC362_RS24825	COG2022	thiamine diphosphate biosynthetic process
HC362_RS24835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC362_RS24835	COG2022	thiamine diphosphate biosynthetic process
HC362_RS24840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC362_RS24850	COG0352	thiamine-phosphate diphosphorylase activity
HC362_RS24870	COG1309	transcriptional regulator
HC362_RS24875	COG1511	domain protein
HC362_RS24880	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HC362_RS24890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC362_RS24910	COG0714	Associated with various cellular activities
HC362_RS24920	COG0275	rRNA processing
HC362_RS24935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC362_RS24945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC362_RS24950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC362_RS24960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC362_RS24965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC362_RS24970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC362_RS24980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC362_RS24985	COG1799	cell septum assembly
HC362_RS24995	COG3599	regulation of cell shape
HC362_RS25000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC362_RS25010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC362_RS25025	COG0025	NhaP-type Na H and K H
HC362_RS25060	COG0587	DNA-directed DNA polymerase activity
HC362_RS25070	COG1432	Conserved Protein
HC362_RS25090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC362_RS25105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC362_RS25110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC362_RS25115	COG0131	Imidazoleglycerol-phosphate dehydratase
HC362_RS25125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC362_RS25130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC362_RS25135	COG0251	oxidation-reduction process
HC362_RS25140	COG0107	imidazoleglycerol-phosphate synthase activity
HC362_RS25165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC362_RS25170	COG1053	succinate dehydrogenase
HC362_RS25190	COG2076	Multidrug Resistance protein
HC362_RS25210	COG0789	Transcriptional regulator
HC362_RS25220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC362_RS25245	COG0134	indole-3-glycerol-phosphate synthase activity
HC362_RS25250	COG0133	tryptophan synthase activity
HC362_RS25255	COG0159	tryptophan synthase activity
HC362_RS25265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC362_RS25270	COG2111	Na H antiporter
HC362_RS25270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC362_RS25275	COG1006	Multisubunit Na H antiporter MnhC subunit
HC362_RS25280	COG0651	ATP synthesis coupled electron transport
HC362_RS25295	COG1320	monovalent cation:proton antiporter activity
HC362_RS25315	COG0069	glutamate synthase activity
HC362_RS25315	COG0067	glutamate synthase
HC362_RS25315	COG0070	glutamate synthase
HC362_RS25355	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS25360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC362_RS25370	COG0702	epimerase
HC362_RS25395	COG3938	Belongs to the proline racemase family
HC362_RS25445	COG2197	response regulator
HC362_RS25455	COG1136	(ABC) transporter
HC362_RS25495	COG3387	PFAM Glycoside hydrolase 15-related
HC362_RS25500	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS25525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS25560	COG0667	Aldo Keto reductase
HC362_RS25570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC362_RS25580	COG2197	response regulator
HC362_RS25605	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC362_RS25665	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS25670	COG1802	Transcriptional regulator
HC362_RS25685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC362_RS25690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC362_RS25695	COG2867	negative regulation of translational initiation
HC362_RS25720	COG0825	malonyl-CoA metabolic process
HC362_RS25720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC362_RS25725	COG0511	ligase activity, forming carbon-carbon bonds
HC362_RS25730	COG0439	Biotin carboxylase
HC362_RS25735	COG0477	Major facilitator Superfamily
HC362_RS25750	COG0346	lactoylglutathione lyase activity
HC362_RS25760	COG2132	Multicopper oxidase
HC362_RS25775	COG3104	oligopeptide transport
HC362_RS25780	COG2345	Transcriptional regulator
HC362_RS25785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS25810	COG0475	glutathione-regulated potassium exporter activity
HC362_RS25820	COG1846	Transcriptional regulator
HC362_RS25840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC362_RS25845	COG2345	Transcriptional regulator
HC362_RS25865	COG0754	glutathionylspermidine amidase activity
HC362_RS25875	COG2124	cytochrome p450
HC362_RS25885	COG0367	asparagine synthase
HC362_RS25890	COG1819	glycosyl
HC362_RS25895	COG2132	Multicopper oxidase
HC362_RS25915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS25935	COG0248	Ppx GppA phosphatase
HC362_RS25945	COG1605	Chorismate mutase
HC362_RS25945	COG0287	Prephenate dehydrogenase
HC362_RS26025	COG2050	protein possibly involved in aromatic compounds catabolism
HC362_RS26060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC362_RS26075	COG0237	dephospho-CoA kinase activity
HC362_RS26100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC362_RS26125	COG2814	Major facilitator Superfamily
HC362_RS26130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC362_RS26135	COG0584	glycerophosphoryl diester phosphodiesterase
HC362_RS26140	COG0556	nucleotide-excision repair
HC362_RS26170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC362_RS26185	COG0322	excinuclease ABC activity
HC362_RS26190	COG1660	Displays ATPase and GTPase activities
HC362_RS26195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC362_RS26200	COG1481	regulation of sporulation
HC362_RS26205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC362_RS26210	COG0126	phosphoglycerate kinase activity
HC362_RS26215	COG0149	triose-phosphate isomerase activity
HC362_RS26220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC362_RS26235	COG0166	Belongs to the GPI family
HC362_RS26240	COG0363	glucosamine-6-phosphate deaminase activity
HC362_RS26255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC362_RS26265	COG0109	protoheme IX farnesyltransferase activity
HC362_RS26285	COG1131	(ABC) transporter
HC362_RS26300	COG0719	Fe-S assembly protein
HC362_RS26310	COG0396	ATPase activity
HC362_RS26315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC362_RS26320	COG0822	iron-sulfur transferase activity
HC362_RS26335	COG3226	Transcriptional regulator
HC362_RS26340	COG2171	N-acyltransferase activity
HC362_RS26360	COG0477	Major facilitator Superfamily
HC362_RS26375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC362_RS26400	COG2261	transglycosylase associated protein
HC362_RS26405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC362_RS26410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC362_RS26420	COG0768	penicillin binding
HC362_RS26425	COG1414	Transcriptional regulator
HC362_RS26440	COG5285	phytanoyl-CoA dioxygenase
HC362_RS26445	COG1917	Cupin 2, conserved barrel domain protein
HC362_RS26450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC362_RS26465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC362_RS26465	COG0825	malonyl-CoA metabolic process
HC362_RS26500	COG1797	cobyrinic acid a,c-diamide synthase activity
HC362_RS26515	COG1492	cobalamin metabolic process
HC362_RS26520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HC362_RS26550	COG0488	(ABC) transporter
HC362_RS26595	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS26605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC362_RS26620	COG0300	oxidoreductase activity
HC362_RS26640	COG1404	Belongs to the peptidase S8 family
HC362_RS26650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC362_RS26655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC362_RS26670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC362_RS26675	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS26680	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC362_RS26685	COG2186	Transcriptional regulator
HC362_RS26690	COG2807	transmembrane transport
HC362_RS26710	COG0560	Phosphoserine phosphatase
HC362_RS26710	COG3830	Belongs to the UPF0237 family
HC362_RS26715	COG1716	ATPase activity
HC362_RS26715	COG1131	(ABC) transporter
HC362_RS26715	COG0842	Transport permease protein
HC362_RS26730	COG2197	response regulator
HC362_RS26745	COG1119	ATPase activity
HC362_RS26770	COG1881	PFAM PEBP family protein
HC362_RS26785	COG2094	Belongs to the DNA glycosylase MPG family
HC362_RS26820	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HC362_RS26825	COG0076	glutamate decarboxylase activity
HC362_RS26835	COG0647	UMP catabolic process
HC362_RS26850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC362_RS26855	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC362_RS26860	COG1120	ATPase activity
HC362_RS26875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC362_RS26880	COG0497	DNA recombination
HC362_RS26890	COG3387	PFAM Glycoside hydrolase 15-related
HC362_RS26895	COG0504	CTP synthase activity
HC362_RS26900	COG0494	nUDIX hydrolase
HC362_RS26910	COG0686	Belongs to the AlaDH PNT family
HC362_RS26925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC362_RS26930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC362_RS26935	COG1187	pseudouridine synthase activity
HC362_RS26955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC362_RS26965	COG1160	GTP binding
HC362_RS26980	COG1652	LysM domain
HC362_RS26985	COG0438	transferase activity, transferring glycosyl groups
HC362_RS27005	COG0671	phosphoesterase, PA-phosphatase related
HC362_RS27015	COG0477	Major facilitator Superfamily
HC362_RS27020	COG1960	acyl-CoA dehydrogenase activity
HC362_RS27025	COG1799	cell septum assembly
HC362_RS27045	COG0587	DNA-directed DNA polymerase activity
HC362_RS27050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC362_RS27090	COG1725	Transcriptional regulator
HC362_RS27110	COG2188	Transcriptional regulator
HC362_RS27115	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HC362_RS27150	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS27170	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HC362_RS27175	COG2149	membrane
HC362_RS27185	COG3265	gluconokinase activity
HC362_RS27295	COG1285	pathogenesis
HC362_RS27305	COG0739	heme binding
HC362_RS27340	COG1234	tRNA 3'-trailer cleavage
HC362_RS27385	COG4214	carbohydrate transport
HC362_RS27390	COG3386	PFAM SMP-30 Gluconolaconase
HC362_RS27395	COG1414	Transcriptional regulator
HC362_RS27420	COG2124	cytochrome p450
HC362_RS27430	COG0583	DNA-binding transcription factor activity
HC362_RS27435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC362_RS27440	COG2186	Transcriptional regulator
HC362_RS27450	COG1653	transport
HC362_RS27455	COG1175	transmembrane transport
HC362_RS27460	COG0395	ABC-type sugar transport system, permease component
HC362_RS27465	COG4948	Mandelate Racemase Muconate Lactonizing
HC362_RS27475	COG0515	serine threonine protein kinase
HC362_RS27485	COG0477	Major facilitator Superfamily
HC362_RS27490	COG0583	DNA-binding transcription factor activity
HC362_RS27495	COG0156	8-amino-7-oxononanoate synthase activity
HC362_RS27500	COG1063	alcohol dehydrogenase
HC362_RS27545	COG3511	phospholipase C
HC362_RS27560	COG0667	Aldo Keto reductase
HC362_RS27590	COG0438	transferase activity, transferring glycosyl groups
HC362_RS27605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC362_RS27605	COG0515	serine threonine protein kinase
HC362_RS27625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC362_RS27655	COG0667	Aldo Keto reductase
HC362_RS27660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS27670	COG0598	Magnesium transport protein CorA
HC362_RS27690	COG0215	cysteine-tRNA ligase activity
HC362_RS27700	COG2186	Transcriptional regulator
HC362_RS27710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC362_RS27715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC362_RS27720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC362_RS27725	COG1414	Transcriptional regulator
HC362_RS27730	COG0646	methionine synthase
HC362_RS27730	COG1410	methionine synthase
HC362_RS27735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC362_RS27740	COG0747	negative chemotaxis
HC362_RS27745	COG2197	response regulator
HC362_RS27755	COG0517	IMP dehydrogenase activity
HC362_RS27755	COG1994	Peptidase M50
HC362_RS27770	COG1222	aaa ATPase
HC362_RS27775	COG4122	O-methyltransferase activity
HC362_RS27790	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HC362_RS27795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HC362_RS27800	COG1609	Transcriptional regulator
HC362_RS27810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HC362_RS27815	COG0545	Peptidyl-prolyl cis-trans isomerase
HC362_RS27840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC362_RS27845	COG0805	protein transport
HC362_RS27865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC362_RS27875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS27890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HC362_RS27895	COG0531	amino acid
HC362_RS27905	COG0174	glutamine synthetase
HC362_RS27910	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS27955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC362_RS27965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC362_RS27970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC362_RS27975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC362_RS27980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC362_RS27985	COG5002	protein histidine kinase activity
HC362_RS27990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC362_RS27995	COG0072	phenylalanine-tRNA ligase activity
HC362_RS27995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC362_RS28000	COG0477	Major facilitator Superfamily
HC362_RS28015	COG0697	spore germination
HC362_RS28020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC362_RS28035	COG0667	Aldo Keto reductase
HC362_RS28045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC362_RS28050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC362_RS28055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HC362_RS28060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC362_RS28065	COG1438	arginine binding
HC362_RS28070	COG0385	Bile acid
HC362_RS28085	COG0165	Argininosuccinate lyase
HC362_RS28100	COG0477	Major facilitator Superfamily
HC362_RS28105	COG0204	Acyl-transferase
HC362_RS28105	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS28110	COG0584	glycerophosphoryl diester phosphodiesterase
HC362_RS28140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC362_RS28150	COG1464	Belongs to the NlpA lipoprotein family
HC362_RS28165	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HC362_RS28170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC362_RS28170	COG1648	precorrin-2 dehydrogenase activity
HC362_RS28180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC362_RS28180	COG0515	serine threonine protein kinase
HC362_RS28290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC362_RS28310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC362_RS28315	COG1560	Kdo2-lipid A biosynthetic process
HC362_RS28320	COG0438	transferase activity, transferring glycosyl groups
HC362_RS28330	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HC362_RS28335	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC362_RS28340	COG0217	transcriptional regulatory protein
HC362_RS28345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HC362_RS28350	COG0632	four-way junction helicase activity
HC362_RS28355	COG2255	four-way junction helicase activity
HC362_RS28365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC362_RS28370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC362_RS28375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC362_RS28380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC362_RS28385	COG1196	nuclear chromosome segregation
HC362_RS28390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC362_RS28400	COG0124	histidyl-tRNA synthetase
HC362_RS28420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC362_RS28435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC362_RS28440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC362_RS28450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC362_RS28455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC362_RS28460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC362_RS28465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC362_RS28475	COG0006	proline dipeptidase activity
HC362_RS28480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC362_RS28485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC362_RS28495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC362_RS28500	COG0540	Belongs to the ATCase OTCase family
HC362_RS28505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC362_RS28515	COG0505	Belongs to the CarA family
HC362_RS28520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC362_RS28525	COG0167	dihydroorotate dehydrogenase activity
HC362_RS28530	COG0284	orotidine-5'-phosphate decarboxylase activity
HC362_RS28540	COG0194	GDP metabolic process
HC362_RS28545	COG1758	RNA polymerase activity
HC362_RS28555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC362_RS28585	COG2814	Major facilitator Superfamily
HC362_RS28600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC362_RS28610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC362_RS28615	COG2390	Transcriptional regulator
HC362_RS28625	COG0475	glutathione-regulated potassium exporter activity
HC362_RS28645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC362_RS28660	COG2233	PERMEase
HC362_RS28665	COG2223	nitrite transmembrane transporter activity
HC362_RS28680	COG3201	nicotinamide mononucleotide transporter
HC362_RS28685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC362_RS28685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC362_RS28690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HC362_RS28695	COG0140	phosphoribosyl-ATP diphosphatase activity
HC362_RS28700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC362_RS28725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC362_RS28725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC362_RS28745	COG0730	response to heat
HC362_RS28750	COG1937	Protein conserved in bacteria
HC362_RS28755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC362_RS28785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC362_RS28840	COG1215	transferase activity, transferring glycosyl groups
HC362_RS28905	COG0431	NADPH-dependent FMN reductase
HC362_RS28940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC362_RS28945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC362_RS28950	COG2124	cytochrome p450
HC362_RS28960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC362_RS28980	COG2197	response regulator
HC362_RS28995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC362_RS29000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC362_RS29000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC362_RS29005	COG1309	transcriptional regulator
HC362_RS29020	COG1960	acyl-CoA dehydrogenase activity
HC362_RS29055	COG0463	Glycosyl transferase, family 2
HC362_RS29070	COG2270	Major facilitator Superfamily
HC362_RS29075	COG0584	glycerophosphoryl diester phosphodiesterase
HC362_RS29085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC362_RS29105	COG1960	acyl-CoA dehydrogenase activity
HC362_RS29115	COG2070	2-Nitropropane dioxygenase
HC362_RS29125	COG0531	amino acid
HC362_RS29140	COG1024	Enoyl-CoA hydratase
HC362_RS29235	COG2018	Roadblock/LC7 domain
HC362_RS29250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC362_RS29255	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HC362_RS29270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC362_RS29275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC362_RS29305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC362_RS29325	COG1716	ATPase activity
HC362_RS29345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC362_RS29355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC362_RS29355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC362_RS29395	COG0542	response to heat
HC362_RS29455	COG0514	ATP-dependent DNA helicase (RecQ)
HC362_RS29485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC362_RS29500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HC362_RS29650	COG0305	Participates in initiation and elongation during chromosome replication
HC362_RS29700	COG0242	peptide deformylase activity
HC362_RS29725	COG1660	Displays ATPase and GTPase activities
HC362_RS29890	COG0584	glycerophosphoryl diester phosphodiesterase
HC362_RS29985	COG1968	undecaprenyl-diphosphatase activity
HC362_RS29995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC362_RS30025	COG0110	maltose O-acetyltransferase activity
HC362_RS30050	COG1832	CoA-binding protein
HC362_RS30055	COG1739	Uncharacterized protein family UPF0029
HC362_RS30060	COG0420	3'-5' exonuclease activity
HC362_RS30065	COG0419	ATPase involved in DNA repair
HC362_RS30095	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC362_RS30095	COG0596	Alpha beta hydrolase
HC362_RS30100	COG1595	DNA-templated transcription, initiation
HC362_RS30105	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS30110	COG2188	Transcriptional regulator
HC362_RS30115	COG1940	carbohydrate kinase activity
HC362_RS30130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC362_RS30160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HC362_RS30165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC362_RS30170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HC362_RS30175	COG0156	8-amino-7-oxononanoate synthase activity
HC362_RS30200	COG0740	serine-type endopeptidase activity
HC362_RS30210	COG2234	aminopeptidase activity
HC362_RS30210	COG4935	Belongs to the peptidase S8 family
HC362_RS30215	COG0831	urea catabolic process
HC362_RS30220	COG0832	Belongs to the urease beta subunit family
HC362_RS30225	COG0804	urea catabolic process
HC362_RS30230	COG0830	nickel cation binding
HC362_RS30235	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HC362_RS30240	COG0829	nickel cation binding
HC362_RS30250	COG0204	Acyl-transferase
HC362_RS30255	COG3629	intracellular signal transduction
HC362_RS30260	COG3321	synthase
HC362_RS30265	COG1960	acyl-CoA dehydrogenase activity
HC362_RS30275	COG2197	response regulator
HC362_RS30295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC362_RS30300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC362_RS30305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC362_RS30310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC362_RS30315	COG0156	8-amino-7-oxononanoate synthase activity
HC362_RS30320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS30330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS30340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC362_RS30345	COG0574	Belongs to the PEP-utilizing enzyme family
HC362_RS30345	COG3848	Pyruvate phosphate dikinase
HC362_RS30375	COG3559	Exporter of polyketide antibiotics
HC362_RS30380	COG1131	(ABC) transporter
HC362_RS30385	COG1309	transcriptional regulator
HC362_RS30400	COG0693	protein deglycase activity
HC362_RS30415	COG3442	glutamine amidotransferase
HC362_RS30425	COG0242	peptide deformylase activity
HC362_RS30465	COG0584	glycerophosphoryl diester phosphodiesterase
HC362_RS30490	COG0367	asparagine synthase
HC362_RS30510	COG2086	electron transfer activity
HC362_RS30515	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC362_RS30545	COG1609	Transcriptional regulator
HC362_RS30560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC362_RS30575	COG1660	Displays ATPase and GTPase activities
HC362_RS30600	COG4585	Histidine kinase
HC362_RS30605	COG2197	response regulator
HC362_RS30620	COG2223	nitrite transmembrane transporter activity
HC362_RS30625	COG1940	carbohydrate kinase activity
HC362_RS30650	COG1136	(ABC) transporter
HC362_RS30655	COG0577	efflux transmembrane transporter activity
HC362_RS30680	COG1349	DNA-binding transcription factor activity
HC362_RS30690	COG0464	growth
HC362_RS30700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC362_RS30705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC362_RS30710	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HC362_RS30720	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS30740	COG0463	Glycosyl transferase, family 2
HC362_RS30745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC362_RS30765	COG1461	Dihydroxyacetone kinase
HC362_RS30770	COG2376	Dihydroxyacetone kinase
HC362_RS30800	COG0583	DNA-binding transcription factor activity
HC362_RS30810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC362_RS30860	COG1486	melibiose metabolic process
HC362_RS30865	COG0395	ABC-type sugar transport system, permease component
HC362_RS30870	COG1175	transmembrane transport
HC362_RS30880	COG1940	carbohydrate kinase activity
HC362_RS30880	COG1846	Transcriptional regulator
HC362_RS30885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC362_RS30900	COG2208	phosphoserine phosphatase activity
HC362_RS30900	COG2172	sigma factor antagonist activity
HC362_RS30900	COG1366	Belongs to the anti-sigma-factor antagonist family
HC362_RS30915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC362_RS30940	COG0492	ferredoxin-NADP+ reductase activity
HC362_RS30955	COG0395	ABC-type sugar transport system, permease component
HC362_RS30980	COG1742	UPF0060 membrane protein
HC362_RS30995	COG0454	-acetyltransferase
HC362_RS31010	COG2755	lipolytic protein G-D-S-L family
HC362_RS31015	COG0640	Transcriptional regulator
HC362_RS31020	COG0604	alcohol dehydrogenase
HC362_RS31030	COG0667	Aldo Keto reductase
HC362_RS31035	COG1116	anion transmembrane transporter activity
HC362_RS31065	COG1115	amino acid carrier protein
HC362_RS31100	COG0395	ABC-type sugar transport system, permease component
HC362_RS31105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS31125	COG0009	L-threonylcarbamoyladenylate synthase
HC362_RS31130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS31190	COG1309	transcriptional regulator
HC362_RS31195	COG0702	epimerase
HC362_RS31205	COG1012	belongs to the aldehyde dehydrogenase family
HC362_RS31235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC362_RS31240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC362_RS31245	COG2080	2 iron, 2 sulfur cluster binding
HC362_RS31260	COG1082	Xylose isomerase domain protein TIM barrel
HC362_RS31265	COG0673	inositol 2-dehydrogenase activity
HC362_RS31270	COG2814	Major facilitator Superfamily
HC362_RS31285	COG3962	Belongs to the TPP enzyme family
HC362_RS31290	COG3718	enzyme involved in inositol metabolism
HC362_RS31300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS31305	COG1609	Transcriptional regulator
HC362_RS31310	COG2066	Belongs to the glutaminase family
HC362_RS31325	COG3387	PFAM Glycoside hydrolase 15-related
HC362_RS31330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC362_RS31345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC362_RS31350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC362_RS31365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS31375	COG1796	DNA polymerase
HC362_RS31375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC362_RS31380	COG0330	HflC and HflK could
HC362_RS31395	COG3321	synthase
HC362_RS31395	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS31395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS31395	COG0318	PFAM AMP-dependent synthetase and ligase
HC362_RS31395	COG0300	oxidoreductase activity
HC362_RS31405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC362_RS31435	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC362_RS31445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC362_RS31485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC362_RS31515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC362_RS31525	COG0583	DNA-binding transcription factor activity
HC362_RS31530	COG5006	permease, DMT superfamily
HC362_RS31540	COG0789	Transcriptional regulator
HC362_RS31620	COG4948	Mandelate Racemase Muconate Lactonizing
HC362_RS31625	COG1733	regulation of RNA biosynthetic process
HC362_RS31655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC362_RS31660	COG0800	Aldolase
HC362_RS31675	COG2610	gluconate transmembrane transporter activity
HC362_RS31680	COG3395	kinase activity
HC362_RS31685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HC362_RS31690	COG1349	DNA-binding transcription factor activity
HC362_RS31710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC362_RS31745	COG0531	amino acid
HC362_RS31750	COG0583	DNA-binding transcription factor activity
HC362_RS31755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC362_RS31775	COG0589	response to stress
HC362_RS31795	COG3387	PFAM Glycoside hydrolase 15-related
HC362_RS31810	COG0110	maltose O-acetyltransferase activity
HC362_RS31820	COG0640	Transcriptional regulator
HC362_RS31850	COG2814	Major facilitator Superfamily
HC362_RS31870	COG1309	transcriptional regulator
HC362_RS31880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC362_RS31885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC362_RS31890	COG1280	lysine exporter protein (LysE YggA)
HC362_RS31945	COG1309	transcriptional regulator
HC362_RS31955	COG2318	DinB family
HC362_RS31965	COG1396	sequence-specific DNA binding
HC362_RS31970	COG0475	glutathione-regulated potassium exporter activity
HC362_RS31990	COG1595	DNA-templated transcription, initiation
HC362_RS32015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS32030	COG2353	YceI-like domain
HC362_RS32040	COG1846	Transcriptional regulator
HC362_RS32050	COG2814	Major facilitator Superfamily
HC362_RS32080	COG0009	L-threonylcarbamoyladenylate synthase
HC362_RS32100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC362_RS32115	COG1309	transcriptional regulator
HC362_RS32120	COG1090	epimerase
HC362_RS32150	COG0488	(ABC) transporter
HC362_RS32155	COG0697	spore germination
HC362_RS32160	COG0438	transferase activity, transferring glycosyl groups
HC362_RS32170	COG2124	cytochrome p450
HC362_RS32180	COG0142	geranyltranstransferase activity
HC362_RS32190	COG2124	cytochrome p450
HC362_RS32200	COG2124	cytochrome p450
HC362_RS32220	COG2226	methyltransferase
HC362_RS32220	COG2867	negative regulation of translational initiation
HC362_RS32225	COG1132	(ABC) transporter
HC362_RS32230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC362_RS32265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC362_RS32270	COG0662	Cupin 2, conserved barrel domain protein
HC362_RS32285	COG2318	DinB family
HC362_RS32295	COG4172	Belongs to the ABC transporter superfamily
HC362_RS32300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC362_RS32310	COG0747	negative chemotaxis
HC362_RS32325	COG4948	Mandelate Racemase Muconate Lactonizing
HC362_RS32330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC362_RS32340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC362_RS32345	COG0596	Alpha beta hydrolase
HC362_RS32355	COG0789	Transcriptional regulator
HC362_RS32360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC362_RS32370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC362_RS32375	COG0640	Transcriptional regulator
HC362_RS32380	COG0798	PFAM Bile acid sodium symporter
HC362_RS32385	COG2226	methyltransferase
HC362_RS32420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC362_RS32425	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC362_RS32430	COG1120	ATPase activity
HC362_RS32435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC362_RS32440	COG0174	glutamine synthetase
HC362_RS32480	COG0019	diaminopimelate decarboxylase activity
HC362_RS32490	COG0477	Major facilitator Superfamily
HC362_RS32520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC362_RS32520	COG0574	Belongs to the PEP-utilizing enzyme family
HC362_RS32535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC362_RS32560	COG2267	carboxylic ester hydrolase activity
HC362_RS32570	COG1595	DNA-templated transcription, initiation
HC362_RS32585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC362_RS32600	COG1320	monovalent cation:proton antiporter activity
HC362_RS32615	COG2111	Na H antiporter
HC362_RS32615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC362_RS32625	COG2197	response regulator
HC362_RS32645	COG0583	DNA-binding transcription factor activity
HC362_RS32660	COG3903	Transcriptional regulator
HC362_RS32660	COG3629	intracellular signal transduction
HC362_RS32675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC362_RS32680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC362_RS32720	COG1309	transcriptional regulator
HC362_RS32730	COG0346	lactoylglutathione lyase activity
HC362_RS32735	COG0640	Transcriptional regulator
HC362_RS32740	COG0793	Belongs to the peptidase S41A family
HC362_RS32740	COG3409	Peptidoglycan-binding domain 1 protein
HC362_RS32780	COG2146	nitrite reductase [NAD(P)H] activity
HC362_RS32815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC362_RS32845	COG3290	protein histidine kinase activity
HC362_RS32860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC362_RS32865	COG1760	l-serine dehydratase
HC362_RS32870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC362_RS32880	COG1131	(ABC) transporter
HC362_RS32970	COG1309	transcriptional regulator
HC362_RS33020	COG1733	regulation of RNA biosynthetic process
HC362_RS33110	COG0644	oxidoreductase
HC362_RS33125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC362_RS33130	COG1309	transcriptional regulator
HC362_RS33135	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS33140	COG1028	Short-chain dehydrogenase reductase Sdr
HC362_RS33165	COG2318	DinB family
HC362_RS33170	COG1846	Transcriptional regulator
HC362_RS33185	COG0395	ABC-type sugar transport system, permease component
HC362_RS33190	COG1175	transmembrane transport
HC362_RS33200	COG1609	Transcriptional regulator
HC362_RS33230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC362_RS33250	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC362_RS33255	COG1140	nitrate reductase beta subunit
HC362_RS33315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC362_RS33330	COG2986	histidine ammonia-lyase
HC362_RS33335	COG4122	O-methyltransferase activity
HC362_RS33345	COG3479	Phenolic acid decarboxylase
HC362_RS33360	COG1620	l-lactate permease
HC362_RS33365	COG0247	lactate metabolic process
HC362_RS33370	COG1139	Iron-sulfur cluster binding protein
HC362_RS33375	COG1556	Lactate utilization protein
HC362_RS33380	COG3548	integral membrane protein
HC362_RS33430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC362_RS33435	COG4977	sequence-specific DNA binding
HC362_RS33475	COG0159	tryptophan synthase activity
HC362_RS33530	COG0477	Major facilitator Superfamily
HC362_RS33540	COG4585	Histidine kinase
HC362_RS33545	COG2409	Drug exporters of the RND superfamily
HC362_RS33555	COG4335	DNA alkylation repair
HC362_RS33575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC362_RS33585	COG0142	geranyltranstransferase activity
HC362_RS33590	COG1562	ergosterol biosynthetic process
HC362_RS33600	COG1131	(ABC) transporter
HC362_RS33630	COG0596	Alpha beta hydrolase
HC362_RS33690	COG2197	response regulator
HC362_RS33695	COG4585	Histidine kinase
HC362_RS33705	COG0577	efflux transmembrane transporter activity
HC362_RS33705	COG1136	(ABC) transporter
HC362_RS33710	COG0515	serine threonine protein kinase
HC362_RS33710	COG2815	serine threonine protein kinase
HC362_RS33830	COG1309	transcriptional regulator
HC362_RS33845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC362_RS33850	COG1051	belongs to the nudix hydrolase family
HC362_RS33915	COG1011	Hydrolase
HC362_RS33940	COG1794	racemase activity, acting on amino acids and derivatives
HC362_RS34035	COG0789	Transcriptional regulator
HC362_RS34050	COG3547	Transposase (IS116 IS110 IS902 family)
HC362_RS34090	COG1309	transcriptional regulator
HC362_RS34180	COG4974	Belongs to the 'phage' integrase family
HC362_RS34225	COG1518	maintenance of DNA repeat elements
HC362_RS34230	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HC362_RS34235	COG3547	Transposase (IS116 IS110 IS902 family)
HC362_RS34275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC362_RS34325	COG1051	belongs to the nudix hydrolase family
HC362_RS34345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC362_RS34360	COG0302	gtp cyclohydrolase
HC362_RS34365	COG0602	queuosine metabolic process
HC362_RS34405	COG0305	Participates in initiation and elongation during chromosome replication
HC362_RS34450	COG0494	nUDIX hydrolase
HC362_RS34495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC362_RS34575	COG3883	PFAM NLP P60 protein
HC362_RS34575	COG0791	NLP P60 protein
HC362_RS34680	COG1674	ftsk spoiiie