locus-tag	class	description
HRD51_RS00010	COG0556	nucleotide-excision repair
HRD51_RS00110	COG4585	Histidine kinase
HRD51_RS00195	COG0577	efflux transmembrane transporter activity
HRD51_RS00195	COG1136	(ABC) transporter
HRD51_RS00200	COG1136	(ABC) transporter
HRD51_RS00215	COG0745	RESPONSE REGULATOR receiver
HRD51_RS00220	COG2205	protein histidine kinase activity
HRD51_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS00315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD51_RS00330	COG0778	Nitroreductase
HRD51_RS00350	COG2318	DinB family
HRD51_RS00365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD51_RS00370	COG3170	Tfp pilus assembly protein FimV
HRD51_RS00375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS00390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD51_RS00405	COG3321	synthase
HRD51_RS00405	COG0604	alcohol dehydrogenase
HRD51_RS00415	COG0604	alcohol dehydrogenase
HRD51_RS00415	COG3321	synthase
HRD51_RS00420	COG0604	alcohol dehydrogenase
HRD51_RS00420	COG3321	synthase
HRD51_RS00430	COG3321	synthase
HRD51_RS00430	COG0604	alcohol dehydrogenase
HRD51_RS00480	COG2205	protein histidine kinase activity
HRD51_RS00485	COG0745	RESPONSE REGULATOR receiver
HRD51_RS00505	COG0531	amino acid
HRD51_RS00520	COG1129	ABC transporter
HRD51_RS00525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD51_RS00550	COG2205	protein histidine kinase activity
HRD51_RS00615	COG1088	dTDP-glucose 4,6-dehydratase activity
HRD51_RS00640	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HRD51_RS00640	COG0456	acetyltransferase
HRD51_RS00645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD51_RS00675	COG1116	anion transmembrane transporter activity
HRD51_RS00680	COG0640	Transcriptional regulator
HRD51_RS00690	COG0390	transport system, permease component
HRD51_RS00695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRD51_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS00715	COG0656	L-ascorbic acid biosynthetic process
HRD51_RS00725	COG2814	Major facilitator Superfamily
HRD51_RS00755	COG0488	(ABC) transporter
HRD51_RS00770	COG2814	Major facilitator Superfamily
HRD51_RS00780	COG1063	alcohol dehydrogenase
HRD51_RS00785	COG1070	Carbohydrate kinase
HRD51_RS00790	COG3485	protocatechuate 3,4-dioxygenase
HRD51_RS00795	COG1505	serine-type exopeptidase activity
HRD51_RS00800	COG0515	serine threonine protein kinase
HRD51_RS00810	COG1278	Cold shock
HRD51_RS00820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS00845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRD51_RS00855	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS00970	COG0667	Aldo Keto reductase
HRD51_RS00985	COG4638	Rieske (2fe-2S)
HRD51_RS00990	COG1063	alcohol dehydrogenase
HRD51_RS01000	COG0667	Aldo Keto reductase
HRD51_RS01060	COG0167	dihydroorotate dehydrogenase activity
HRD51_RS01070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS01075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD51_RS01090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS01100	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRD51_RS01105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS01115	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HRD51_RS01135	COG2318	DinB family
HRD51_RS01145	COG3795	YCII-related domain
HRD51_RS01150	COG4941	Belongs to the sigma-70 factor family
HRD51_RS01195	COG2124	cytochrome p450
HRD51_RS01230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD51_RS01235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS01240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS01245	COG1309	transcriptional regulator
HRD51_RS01265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRD51_RS01315	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRD51_RS01365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS01380	COG0561	phosphatase activity
HRD51_RS01385	COG2124	cytochrome p450
HRD51_RS01405	COG1309	transcriptional regulator
HRD51_RS01470	COG0154	amidase activity
HRD51_RS01475	COG2135	peptidase activity
HRD51_RS01505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRD51_RS01510	COG0142	geranyltranstransferase activity
HRD51_RS01530	COG0346	lactoylglutathione lyase activity
HRD51_RS01535	COG0640	Transcriptional regulator
HRD51_RS01545	COG2409	Drug exporters of the RND superfamily
HRD51_RS01645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRD51_RS01650	COG2201	protein-glutamate methylesterase activity
HRD51_RS01660	COG0586	Pfam SNARE associated Golgi protein
HRD51_RS01675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD51_RS01680	COG1280	lysine exporter protein (LysE YggA)
HRD51_RS01685	COG0477	Major facilitator Superfamily
HRD51_RS01730	COG3896	Chloramphenicol phosphotransferase-like protein
HRD51_RS01760	COG3973	AAA domain
HRD51_RS01790	COG0745	RESPONSE REGULATOR receiver
HRD51_RS01815	COG1846	Transcriptional regulator
HRD51_RS01850	COG4221	oxidoreductase activity
HRD51_RS01865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HRD51_RS01895	COG0714	Associated with various cellular activities
HRD51_RS01900	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HRD51_RS01910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD51_RS01920	COG0463	Glycosyl transferase, family 2
HRD51_RS01925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD51_RS01930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD51_RS01955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS01975	COG1309	transcriptional regulator
HRD51_RS02000	COG0477	Major facilitator Superfamily
HRD51_RS02005	COG1335	isochorismatase
HRD51_RS02050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRD51_RS02070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD51_RS02075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD51_RS02080	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HRD51_RS02135	COG1404	Belongs to the peptidase S8 family
HRD51_RS02205	COG1309	transcriptional regulator
HRD51_RS02210	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRD51_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS02275	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS02290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD51_RS02295	COG3485	protocatechuate 3,4-dioxygenase
HRD51_RS02365	COG2319	Wd-40 repeat
HRD51_RS02365	COG4249	Peptidase C14 caspase catalytic subunit p20
HRD51_RS02395	COG2197	response regulator
HRD51_RS02410	COG2272	Belongs to the type-B carboxylesterase lipase family
HRD51_RS02420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRD51_RS02430	COG1073	alpha beta
HRD51_RS02445	COG1024	Enoyl-CoA hydratase
HRD51_RS02490	COG0488	(ABC) transporter
HRD51_RS02495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS02500	COG2318	DinB family
HRD51_RS02505	COG0326	Molecular chaperone. Has ATPase activity
HRD51_RS02545	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HRD51_RS02560	COG2124	cytochrome p450
HRD51_RS02570	COG0596	Alpha beta hydrolase
HRD51_RS02590	COG1461	Dihydroxyacetone kinase
HRD51_RS02595	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HRD51_RS02615	COG0697	spore germination
HRD51_RS02630	COG1254	Belongs to the acylphosphatase family
HRD51_RS02650	COG3340	Belongs to the peptidase S51 family
HRD51_RS02680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRD51_RS02695	COG3226	Transcriptional regulator
HRD51_RS02700	COG2267	carboxylic ester hydrolase activity
HRD51_RS02765	COG0583	DNA-binding transcription factor activity
HRD51_RS02800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRD51_RS02805	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS02810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRD51_RS02815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS02820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS02875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD51_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS02920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD51_RS02930	COG1595	DNA-templated transcription, initiation
HRD51_RS02945	COG0583	DNA-binding transcription factor activity
HRD51_RS02960	COG0738	Major facilitator superfamily
HRD51_RS03015	COG2207	Transcriptional regulator
HRD51_RS03020	COG2223	nitrite transmembrane transporter activity
HRD51_RS03030	COG2124	cytochrome p450
HRD51_RS03040	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRD51_RS03055	COG2197	response regulator
HRD51_RS03075	COG1191	sigma factor activity
HRD51_RS03080	COG1819	glycosyl
HRD51_RS03115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRD51_RS03135	COG0701	Predicted permease
HRD51_RS03140	COG0745	RESPONSE REGULATOR receiver
HRD51_RS03155	COG1959	2 iron, 2 sulfur cluster binding
HRD51_RS03160	COG1017	nitric oxide dioxygenase activity
HRD51_RS03160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD51_RS03180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD51_RS03215	COG0154	amidase activity
HRD51_RS03240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS03245	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS03315	COG1940	carbohydrate kinase activity
HRD51_RS03325	COG2080	2 iron, 2 sulfur cluster binding
HRD51_RS03330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HRD51_RS03335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRD51_RS03340	COG0515	serine threonine protein kinase
HRD51_RS03340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD51_RS03370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRD51_RS03380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD51_RS03390	COG0542	response to heat
HRD51_RS03400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRD51_RS03405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS03410	COG2267	carboxylic ester hydrolase activity
HRD51_RS03430	COG3387	PFAM Glycoside hydrolase 15-related
HRD51_RS03450	COG2226	methyltransferase
HRD51_RS03470	COG4221	oxidoreductase activity
HRD51_RS03545	COG2132	Multicopper oxidase
HRD51_RS03565	COG2824	Alkylphosphonate utilization operon protein PhnA
HRD51_RS03615	COG0583	DNA-binding transcription factor activity
HRD51_RS03670	COG2205	protein histidine kinase activity
HRD51_RS03695	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS03705	COG0640	Transcriptional regulator
HRD51_RS03710	COG1476	TRANSCRIPTIONal
HRD51_RS03730	COG0667	Aldo Keto reductase
HRD51_RS03735	COG0657	acetylesterase activity
HRD51_RS03755	COG4585	Histidine kinase
HRD51_RS03760	COG2197	response regulator
HRD51_RS03790	COG0745	RESPONSE REGULATOR receiver
HRD51_RS03810	COG1309	transcriptional regulator
HRD51_RS03815	COG0596	Alpha beta hydrolase
HRD51_RS03820	COG1802	Transcriptional regulator
HRD51_RS03845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS03940	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD51_RS03945	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD51_RS03950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HRD51_RS03995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HRD51_RS04005	COG0330	HflC and HflK could
HRD51_RS04015	COG0589	response to stress
HRD51_RS04025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD51_RS04030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRD51_RS04035	COG0022	dehydrogenase e1 component
HRD51_RS04035	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD51_RS04040	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD51_RS04090	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HRD51_RS04140	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HRD51_RS04155	COG0589	response to stress
HRD51_RS04175	COG0574	Belongs to the PEP-utilizing enzyme family
HRD51_RS04175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD51_RS04205	COG2239	Acts as a magnesium transporter
HRD51_RS04225	COG1695	Transcriptional regulator
HRD51_RS04230	COG2259	Doxx family
HRD51_RS04260	COG3383	formate dehydrogenase (NAD+) activity
HRD51_RS04285	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HRD51_RS04290	COG0517	IMP dehydrogenase activity
HRD51_RS04290	COG0617	tRNA 3'-terminal CCA addition
HRD51_RS04290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRD51_RS04305	COG0589	response to stress
HRD51_RS04365	COG2205	protein histidine kinase activity
HRD51_RS04370	COG0745	RESPONSE REGULATOR receiver
HRD51_RS04390	COG0659	secondary active sulfate transmembrane transporter activity
HRD51_RS04420	COG3260	NADH ubiquinone oxidoreductase 20
HRD51_RS04440	COG0651	ATP synthesis coupled electron transport
HRD51_RS04515	COG0202	RNA polymerase activity
HRD51_RS04550	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD51_RS04555	COG0181	hydroxymethylbilane synthase activity
HRD51_RS04590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRD51_RS04600	COG1794	racemase activity, acting on amino acids and derivatives
HRD51_RS04630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD51_RS04655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRD51_RS04695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD51_RS04805	COG0805	protein transport
HRD51_RS04820	COG0513	Belongs to the DEAD box helicase family
HRD51_RS04830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD51_RS04850	COG1278	Cold shock
HRD51_RS04905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD51_RS05005	COG0285	dihydrofolate synthase activity
HRD51_RS05010	COG0746	molybdenum cofactor guanylyltransferase activity
HRD51_RS05030	COG3251	PFAM MbtH domain protein
HRD51_RS05040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRD51_RS05045	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HRD51_RS05065	COG0367	asparagine synthase
HRD51_RS05100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRD51_RS05115	COG4310	Domain of unknown function (DUF2172)
HRD51_RS05125	COG1215	transferase activity, transferring glycosyl groups
HRD51_RS05140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRD51_RS05165	COG2205	protein histidine kinase activity
HRD51_RS05170	COG0745	RESPONSE REGULATOR receiver
HRD51_RS05175	COG2815	serine threonine protein kinase
HRD51_RS05175	COG0515	serine threonine protein kinase
HRD51_RS05220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD51_RS05225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRD51_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS05350	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS05360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRD51_RS05370	COG0301	tRNA thio-modification
HRD51_RS05375	COG3959	Transketolase, thiamine diphosphate binding domain
HRD51_RS05380	COG3903	Transcriptional regulator
HRD51_RS05380	COG3629	intracellular signal transduction
HRD51_RS05385	COG1120	ATPase activity
HRD51_RS05390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS05395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD51_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS05440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS05440	COG3321	synthase
HRD51_RS05440	COG4221	oxidoreductase activity
HRD51_RS05440	COG0300	oxidoreductase activity
HRD51_RS05445	COG0367	asparagine synthase
HRD51_RS05460	COG0583	DNA-binding transcription factor activity
HRD51_RS05505	COG0584	glycerophosphoryl diester phosphodiesterase
HRD51_RS05600	COG1982	Orn Lys Arg decarboxylase major
HRD51_RS05615	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HRD51_RS05630	COG0583	DNA-binding transcription factor activity
HRD51_RS05655	COG2267	carboxylic ester hydrolase activity
HRD51_RS05755	COG4585	Histidine kinase
HRD51_RS05760	COG2197	response regulator
HRD51_RS05820	COG0456	acetyltransferase
HRD51_RS05845	COG1484	DNA-dependent DNA replication
HRD51_RS05900	COG0513	Belongs to the DEAD box helicase family
HRD51_RS05905	COG1278	Cold shock
HRD51_RS05930	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HRD51_RS05975	COG1024	Enoyl-CoA hydratase
HRD51_RS05980	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS06015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HRD51_RS06025	COG0154	amidase activity
HRD51_RS06030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD51_RS06040	COG0456	acetyltransferase
HRD51_RS06040	COG1846	Transcriptional regulator
HRD51_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS06085	COG0739	heme binding
HRD51_RS06110	COG3629	intracellular signal transduction
HRD51_RS06110	COG3903	Transcriptional regulator
HRD51_RS06205	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HRD51_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS06225	COG2814	Major facilitator Superfamily
HRD51_RS06255	COG3321	synthase
HRD51_RS06255	COG0604	alcohol dehydrogenase
HRD51_RS06255	COG0604	alcohol dehydrogenase
HRD51_RS06255	COG3321	synthase
HRD51_RS06260	COG3321	synthase
HRD51_RS06260	COG0604	alcohol dehydrogenase
HRD51_RS06265	COG2197	response regulator
HRD51_RS06285	COG1228	amidohydrolase
HRD51_RS06290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HRD51_RS06305	COG3655	Transcriptional regulator
HRD51_RS06310	COG0644	oxidoreductase
HRD51_RS06330	COG0456	acetyltransferase
HRD51_RS06385	COG0583	DNA-binding transcription factor activity
HRD51_RS06390	COG4221	oxidoreductase activity
HRD51_RS06395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD51_RS06410	COG3186	Phenylalanine-4-hydroxylase
HRD51_RS06420	COG1231	oxidoreductase activity
HRD51_RS06425	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD51_RS06430	COG2192	nodulation
HRD51_RS06435	COG3293	Transposase
HRD51_RS06455	COG2197	response regulator
HRD51_RS06460	COG4585	Histidine kinase
HRD51_RS06475	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HRD51_RS06480	COG2197	response regulator
HRD51_RS06480	COG3903	Transcriptional regulator
HRD51_RS06525	COG1819	glycosyl
HRD51_RS06535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS06545	COG1846	Transcriptional regulator
HRD51_RS06580	COG0702	epimerase
HRD51_RS06585	COG1733	regulation of RNA biosynthetic process
HRD51_RS06605	COG0697	spore germination
HRD51_RS06615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD51_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS06690	COG4585	Histidine kinase
HRD51_RS06700	COG0590	tRNA wobble adenosine to inosine editing
HRD51_RS06715	COG0583	DNA-binding transcription factor activity
HRD51_RS06775	COG2815	serine threonine protein kinase
HRD51_RS06775	COG0515	serine threonine protein kinase
HRD51_RS06780	COG2391	methyltransferase activity
HRD51_RS06800	COG1595	DNA-templated transcription, initiation
HRD51_RS06830	COG0596	Alpha beta hydrolase
HRD51_RS06870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD51_RS06895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD51_RS06915	COG1902	pentaerythritol trinitrate reductase activity
HRD51_RS06925	COG3979	chitinase
HRD51_RS06945	COG3387	PFAM Glycoside hydrolase 15-related
HRD51_RS06985	COG0300	oxidoreductase activity
HRD51_RS07025	COG2124	cytochrome p450
HRD51_RS07040	COG0542	response to heat
HRD51_RS07110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD51_RS07120	COG3290	protein histidine kinase activity
HRD51_RS07125	COG4565	transcriptional regulatory protein
HRD51_RS07135	COG2267	carboxylic ester hydrolase activity
HRD51_RS07140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRD51_RS07145	COG0076	glutamate decarboxylase activity
HRD51_RS07160	COG0789	Transcriptional regulator
HRD51_RS07175	COG2186	Transcriptional regulator
HRD51_RS07195	COG0640	Transcriptional regulator
HRD51_RS07200	COG0531	amino acid
HRD51_RS07210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD51_RS07240	COG0529	Catalyzes the synthesis of activated sulfate
HRD51_RS07310	COG2197	response regulator
HRD51_RS07315	COG4585	Histidine kinase
HRD51_RS07345	COG0494	nUDIX hydrolase
HRD51_RS07375	COG0531	amino acid
HRD51_RS07385	COG0772	Belongs to the SEDS family
HRD51_RS07405	COG0076	glutamate decarboxylase activity
HRD51_RS07455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRD51_RS07490	COG2309	aminopeptidase activity
HRD51_RS07520	COG1335	isochorismatase
HRD51_RS07525	COG0596	Alpha beta hydrolase
HRD51_RS07535	COG2226	methyltransferase
HRD51_RS07585	COG2274	protein secretion by the type I secretion system
HRD51_RS07600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HRD51_RS07600	COG1796	DNA polymerase
HRD51_RS07605	COG0583	DNA-binding transcription factor activity
HRD51_RS07610	COG0156	8-amino-7-oxononanoate synthase activity
HRD51_RS07615	COG1063	alcohol dehydrogenase
HRD51_RS07640	COG2318	DinB family
HRD51_RS07660	COG1522	sequence-specific DNA binding
HRD51_RS07670	COG1687	branched-chain amino acid
HRD51_RS07695	COG0745	RESPONSE REGULATOR receiver
HRD51_RS07700	COG1024	Enoyl-CoA hydratase
HRD51_RS07700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD51_RS07720	COG0477	Major facilitator Superfamily
HRD51_RS07755	COG3585	molybdate ion transport
HRD51_RS07770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRD51_RS07770	COG2080	2 iron, 2 sulfur cluster binding
HRD51_RS07775	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HRD51_RS07780	COG3835	regulator
HRD51_RS07830	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HRD51_RS07845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD51_RS07870	COG0297	glycogen (starch) synthase activity
HRD51_RS07925	COG2226	methyltransferase
HRD51_RS07940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS07945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS08000	COG0154	amidase activity
HRD51_RS08020	COG0386	Belongs to the glutathione peroxidase family
HRD51_RS08045	COG1132	(ABC) transporter
HRD51_RS08055	COG0673	inositol 2-dehydrogenase activity
HRD51_RS08075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRD51_RS08080	COG0667	Aldo Keto reductase
HRD51_RS08105	COG1562	ergosterol biosynthetic process
HRD51_RS08110	COG0142	geranyltranstransferase activity
HRD51_RS08155	COG0367	asparagine synthase
HRD51_RS08160	COG0477	Major facilitator Superfamily
HRD51_RS08165	COG2608	mercury ion transmembrane transporter activity
HRD51_RS08170	COG1120	ATPase activity
HRD51_RS08175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS08200	COG0477	Major facilitator Superfamily
HRD51_RS08215	COG0640	Transcriptional regulator
HRD51_RS08225	COG2843	Capsule synthesis protein
HRD51_RS08230	COG4106	trans-aconitate 2-methyltransferase activity
HRD51_RS08235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD51_RS08250	COG0667	Aldo Keto reductase
HRD51_RS08260	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS08280	COG0477	Major facilitator Superfamily
HRD51_RS08310	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS08320	COG0583	DNA-binding transcription factor activity
HRD51_RS08325	COG0697	spore germination
HRD51_RS08345	COG0492	ferredoxin-NADP+ reductase activity
HRD51_RS08390	COG1695	Transcriptional regulator
HRD51_RS08425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD51_RS08425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD51_RS08435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD51_RS08455	COG1716	ATPase activity
HRD51_RS08475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRD51_RS08505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD51_RS08515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD51_RS08525	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HRD51_RS08535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD51_RS08540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD51_RS08550	COG0596	Alpha beta hydrolase
HRD51_RS08590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HRD51_RS08610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRD51_RS08615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRD51_RS08620	COG1984	allophanate hydrolase subunit 2
HRD51_RS08640	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS08720	COG1024	Enoyl-CoA hydratase
HRD51_RS08730	COG1605	Chorismate mutase
HRD51_RS08750	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS08770	COG2070	2-Nitropropane dioxygenase
HRD51_RS08785	COG0515	serine threonine protein kinase
HRD51_RS08795	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS08815	COG2226	methyltransferase
HRD51_RS08830	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HRD51_RS08840	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HRD51_RS08860	COG0454	-acetyltransferase
HRD51_RS08860	COG0456	acetyltransferase
HRD51_RS08875	COG2267	carboxylic ester hydrolase activity
HRD51_RS08900	COG0604	alcohol dehydrogenase
HRD51_RS08905	COG2376	Dihydroxyacetone kinase
HRD51_RS08910	COG1461	Dihydroxyacetone kinase
HRD51_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS08950	COG0583	DNA-binding transcription factor activity
HRD51_RS08975	COG0395	ABC-type sugar transport system, permease component
HRD51_RS09020	COG2816	NAD+ diphosphatase activity
HRD51_RS09030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRD51_RS09035	COG0463	Glycosyl transferase, family 2
HRD51_RS09050	COG3217	Mosc domain protein beta barrel domain protein
HRD51_RS09050	COG0633	Ferredoxin
HRD51_RS09090	COG2318	DinB family
HRD51_RS09120	COG0464	growth
HRD51_RS09130	COG1349	DNA-binding transcription factor activity
HRD51_RS09175	COG1940	carbohydrate kinase activity
HRD51_RS09180	COG2223	nitrite transmembrane transporter activity
HRD51_RS09190	COG2197	response regulator
HRD51_RS09195	COG4585	Histidine kinase
HRD51_RS09200	COG0445	tRNA wobble uridine modification
HRD51_RS09235	COG0477	Major facilitator Superfamily
HRD51_RS09245	COG2318	DinB family
HRD51_RS09250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRD51_RS09295	COG0584	glycerophosphoryl diester phosphodiesterase
HRD51_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS09375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRD51_RS09380	COG0140	phosphoribosyl-ATP diphosphatase activity
HRD51_RS09385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRD51_RS09390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD51_RS09390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD51_RS09395	COG3201	nicotinamide mononucleotide transporter
HRD51_RS09410	COG1090	epimerase
HRD51_RS09415	COG1940	carbohydrate kinase activity
HRD51_RS09415	COG1846	Transcriptional regulator
HRD51_RS09420	COG2223	nitrite transmembrane transporter activity
HRD51_RS09430	COG2233	PERMEase
HRD51_RS09445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS09455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD51_RS09475	COG0531	amino acid
HRD51_RS09495	COG2390	Transcriptional regulator
HRD51_RS09500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD51_RS09505	COG2838	Isocitrate dehydrogenase
HRD51_RS09515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD51_RS09530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRD51_RS09555	COG0284	orotidine-5'-phosphate decarboxylase activity
HRD51_RS09560	COG0167	dihydroorotate dehydrogenase activity
HRD51_RS09565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRD51_RS09570	COG0505	Belongs to the CarA family
HRD51_RS09580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRD51_RS09585	COG0540	Belongs to the ATCase OTCase family
HRD51_RS09590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRD51_RS09600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD51_RS09605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD51_RS09610	COG0006	proline dipeptidase activity
HRD51_RS09620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRD51_RS09625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRD51_RS09630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD51_RS09635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRD51_RS09640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD51_RS09650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRD51_RS09655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRD51_RS09670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRD51_RS09690	COG0124	histidyl-tRNA synthetase
HRD51_RS09700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD51_RS09705	COG1196	nuclear chromosome segregation
HRD51_RS09720	COG0515	serine threonine protein kinase
HRD51_RS09725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD51_RS09730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRD51_RS09735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD51_RS09740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD51_RS09750	COG2255	four-way junction helicase activity
HRD51_RS09755	COG0632	four-way junction helicase activity
HRD51_RS09760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRD51_RS09765	COG0217	transcriptional regulatory protein
HRD51_RS09770	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HRD51_RS09775	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HRD51_RS09785	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS09790	COG1560	Kdo2-lipid A biosynthetic process
HRD51_RS09795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRD51_RS09825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRD51_RS09840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD51_RS09895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRD51_RS09940	COG1648	precorrin-2 dehydrogenase activity
HRD51_RS09940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD51_RS09945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRD51_RS09960	COG1464	Belongs to the NlpA lipoprotein family
HRD51_RS09965	COG2011	ABC-type metal ion transport system permease component
HRD51_RS09970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD51_RS09990	COG0584	glycerophosphoryl diester phosphodiesterase
HRD51_RS10005	COG0477	Major facilitator Superfamily
HRD51_RS10015	COG0165	Argininosuccinate lyase
HRD51_RS10020	COG0137	argininosuccinate synthase activity
HRD51_RS10040	COG1438	arginine binding
HRD51_RS10045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD51_RS10050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD51_RS10055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRD51_RS10065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRD51_RS10080	COG1309	transcriptional regulator
HRD51_RS10090	COG4106	trans-aconitate 2-methyltransferase activity
HRD51_RS10105	COG0456	acetyltransferase
HRD51_RS10115	COG0697	spore germination
HRD51_RS10125	COG1649	PFAM Uncharacterised BCR, COG1649
HRD51_RS10220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRD51_RS10225	COG0583	DNA-binding transcription factor activity
HRD51_RS10270	COG3629	intracellular signal transduction
HRD51_RS10270	COG3903	Transcriptional regulator
HRD51_RS10275	COG3903	Transcriptional regulator
HRD51_RS10275	COG3629	intracellular signal transduction
HRD51_RS10295	COG0494	nUDIX hydrolase
HRD51_RS10305	COG0072	phenylalanine-tRNA ligase activity
HRD51_RS10305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD51_RS10310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRD51_RS10315	COG5002	protein histidine kinase activity
HRD51_RS10320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD51_RS10325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRD51_RS10330	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRD51_RS10335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRD51_RS10345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD51_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS10380	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS10390	COG2186	Transcriptional regulator
HRD51_RS10395	COG1113	amino acid transport
HRD51_RS10400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HRD51_RS10420	COG2233	PERMEase
HRD51_RS10445	COG4176	ABC-type proline glycine betaine transport system permease component
HRD51_RS10450	COG4175	Glycine betaine
HRD51_RS10450	COG0517	IMP dehydrogenase activity
HRD51_RS10455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD51_RS10475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS10485	COG0805	protein transport
HRD51_RS10490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD51_RS10520	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRD51_RS10525	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HRD51_RS10535	COG1609	Transcriptional regulator
HRD51_RS10540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HRD51_RS10545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HRD51_RS10560	COG4122	O-methyltransferase activity
HRD51_RS10565	COG1222	aaa ATPase
HRD51_RS10585	COG0517	IMP dehydrogenase activity
HRD51_RS10585	COG1994	Peptidase M50
HRD51_RS10595	COG2197	response regulator
HRD51_RS10605	COG0747	negative chemotaxis
HRD51_RS10610	COG0546	phosphoglycolate phosphatase activity
HRD51_RS10615	COG0646	methionine synthase
HRD51_RS10615	COG1410	methionine synthase
HRD51_RS10620	COG1414	Transcriptional regulator
HRD51_RS10625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD51_RS10630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD51_RS10635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD51_RS10640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS10645	COG2186	Transcriptional regulator
HRD51_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS10655	COG3618	amidohydrolase
HRD51_RS10665	COG4214	carbohydrate transport
HRD51_RS10670	COG1129	ABC transporter
HRD51_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS10685	COG4948	Mandelate Racemase Muconate Lactonizing
HRD51_RS10695	COG0215	cysteine-tRNA ligase activity
HRD51_RS10715	COG0598	Magnesium transport protein CorA
HRD51_RS10725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS10730	COG0667	Aldo Keto reductase
HRD51_RS10760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD51_RS10775	COG0488	(ABC) transporter
HRD51_RS10780	COG2124	cytochrome p450
HRD51_RS10790	COG0745	RESPONSE REGULATOR receiver
HRD51_RS10820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD51_RS10825	COG2149	membrane
HRD51_RS10845	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS10850	COG1309	transcriptional regulator
HRD51_RS10855	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS10875	COG3876	Protein conserved in bacteria
HRD51_RS10880	COG0477	Major facilitator Superfamily
HRD51_RS10930	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS10940	COG4413	Urea transporter
HRD51_RS10955	COG1309	transcriptional regulator
HRD51_RS10960	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HRD51_RS10965	COG2188	Transcriptional regulator
HRD51_RS10970	COG2814	Major facilitator Superfamily
HRD51_RS10970	COG0477	Major facilitator Superfamily
HRD51_RS11015	COG1834	amidinotransferase
HRD51_RS11020	COG1725	Transcriptional regulator
HRD51_RS11025	COG0367	asparagine synthase
HRD51_RS11035	COG2226	methyltransferase
HRD51_RS11050	COG1522	sequence-specific DNA binding
HRD51_RS11055	COG0531	amino acid
HRD51_RS11065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD51_RS11070	COG0587	DNA-directed DNA polymerase activity
HRD51_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS11100	COG0330	HflC and HflK could
HRD51_RS11115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS11125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD51_RS11130	COG1126	abc transporter atp-binding protein
HRD51_RS11145	COG0765	amino acid transport
HRD51_RS11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD51_RS11160	COG1799	cell septum assembly
HRD51_RS11165	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS11170	COG0477	Major facilitator Superfamily
HRD51_RS11180	COG0671	phosphoesterase, PA-phosphatase related
HRD51_RS11190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD51_RS11195	COG0789	Transcriptional regulator
HRD51_RS11205	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS11210	COG3583	domain protein
HRD51_RS11225	COG1160	GTP binding
HRD51_RS11235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRD51_RS11255	COG3541	Predicted nucleotidyltransferase
HRD51_RS11265	COG1187	pseudouridine synthase activity
HRD51_RS11270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRD51_RS11275	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HRD51_RS11290	COG0686	Belongs to the AlaDH PNT family
HRD51_RS11300	COG0494	nUDIX hydrolase
HRD51_RS11305	COG0504	CTP synthase activity
HRD51_RS11310	COG3387	PFAM Glycoside hydrolase 15-related
HRD51_RS11330	COG0497	DNA recombination
HRD51_RS11340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRD51_RS11360	COG1120	ATPase activity
HRD51_RS11365	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS11370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS11385	COG0647	UMP catabolic process
HRD51_RS11400	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HRD51_RS11440	COG2094	Belongs to the DNA glycosylase MPG family
HRD51_RS11450	COG1881	PFAM PEBP family protein
HRD51_RS11475	COG1119	ATPase activity
HRD51_RS11495	COG2197	response regulator
HRD51_RS11500	COG4585	Histidine kinase
HRD51_RS11510	COG3953	SLT domain
HRD51_RS11510	COG5280	Phage tail tape measure protein TP901
HRD51_RS11515	COG0842	Transport permease protein
HRD51_RS11515	COG1131	(ABC) transporter
HRD51_RS11515	COG1716	ATPase activity
HRD51_RS11520	COG0560	Phosphoserine phosphatase
HRD51_RS11520	COG3830	Belongs to the UPF0237 family
HRD51_RS11540	COG2186	Transcriptional regulator
HRD51_RS11545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRD51_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS11565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRD51_RS11580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRD51_RS11585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD51_RS11600	COG1404	Belongs to the peptidase S8 family
HRD51_RS11630	COG0300	oxidoreductase activity
HRD51_RS11660	COG3387	PFAM Glycoside hydrolase 15-related
HRD51_RS11690	COG1302	Protein conserved in bacteria
HRD51_RS11700	COG1024	Enoyl-CoA hydratase
HRD51_RS11710	COG0488	(ABC) transporter
HRD51_RS11730	COG0235	Class ii aldolase
HRD51_RS11770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRD51_RS11775	COG1492	cobalamin metabolic process
HRD51_RS11790	COG1797	cobyrinic acid a,c-diamide synthase activity
HRD51_RS11820	COG0456	acetyltransferase
HRD51_RS11825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRD51_RS11830	COG1917	Cupin 2, conserved barrel domain protein
HRD51_RS11840	COG1902	pentaerythritol trinitrate reductase activity
HRD51_RS11870	COG1414	Transcriptional regulator
HRD51_RS11890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD51_RS11895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD51_RS11900	COG2261	transglycosylase associated protein
HRD51_RS11915	COG2226	methyltransferase
HRD51_RS11935	COG0675	Transposase, IS605 OrfB family
HRD51_RS11950	COG2171	N-acyltransferase activity
HRD51_RS11955	COG3226	Transcriptional regulator
HRD51_RS11960	COG2076	Multidrug Resistance protein
HRD51_RS11965	COG2151	metal-sulfur cluster biosynthetic enzyme
HRD51_RS11970	COG0822	iron-sulfur transferase activity
HRD51_RS11975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD51_RS11980	COG0396	ATPase activity
HRD51_RS11990	COG0719	Fe-S assembly protein
HRD51_RS12005	COG1131	(ABC) transporter
HRD51_RS12015	COG1612	heme a metabolic process
HRD51_RS12030	COG0109	protoheme IX farnesyltransferase activity
HRD51_RS12035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRD51_RS12040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD51_RS12055	COG0363	glucosamine-6-phosphate deaminase activity
HRD51_RS12060	COG0166	Belongs to the GPI family
HRD51_RS12070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRD51_RS12075	COG0149	triose-phosphate isomerase activity
HRD51_RS12080	COG0126	phosphoglycerate kinase activity
HRD51_RS12085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRD51_RS12090	COG1481	regulation of sporulation
HRD51_RS12095	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRD51_RS12100	COG1660	Displays ATPase and GTPase activities
HRD51_RS12105	COG0322	excinuclease ABC activity
HRD51_RS12130	COG2814	Major facilitator Superfamily
HRD51_RS12135	COG1063	alcohol dehydrogenase
HRD51_RS12140	COG1609	Transcriptional regulator
HRD51_RS12150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRD51_RS12185	COG0556	nucleotide-excision repair
HRD51_RS12190	COG0584	glycerophosphoryl diester phosphodiesterase
HRD51_RS12195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD51_RS12245	COG3903	Transcriptional regulator
HRD51_RS12245	COG3629	intracellular signal transduction
HRD51_RS12265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRD51_RS12290	COG0237	dephospho-CoA kinase activity
HRD51_RS12305	COG0539	negative regulation of cytoplasmic translation
HRD51_RS12310	COG1073	alpha beta
HRD51_RS12310	COG2226	methyltransferase
HRD51_RS12370	COG0411	ABC transporter
HRD51_RS12410	COG0737	Belongs to the 5'-nucleotidase family
HRD51_RS12440	COG0366	Alpha amylase catalytic
HRD51_RS12440	COG1470	cell adhesion involved in biofilm formation
HRD51_RS12450	COG2197	response regulator
HRD51_RS12485	COG3467	pyridoxamine 5'-phosphate
HRD51_RS12500	COG0640	Transcriptional regulator
HRD51_RS12515	COG0067	glutamate synthase
HRD51_RS12515	COG0069	glutamate synthase activity
HRD51_RS12515	COG0070	glutamate synthase
HRD51_RS12530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRD51_RS12540	COG0159	tryptophan synthase activity
HRD51_RS12545	COG0133	tryptophan synthase activity
HRD51_RS12550	COG0134	indole-3-glycerol-phosphate synthase activity
HRD51_RS12575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRD51_RS12590	COG0583	DNA-binding transcription factor activity
HRD51_RS12600	COG1053	succinate dehydrogenase
HRD51_RS12605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD51_RS12610	COG0107	imidazoleglycerol-phosphate synthase activity
HRD51_RS12615	COG0251	oxidation-reduction process
HRD51_RS12620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRD51_RS12625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRD51_RS12635	COG0131	Imidazoleglycerol-phosphate dehydratase
HRD51_RS12640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD51_RS12645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRD51_RS12660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRD51_RS12680	COG1432	Conserved Protein
HRD51_RS12690	COG0587	DNA-directed DNA polymerase activity
HRD51_RS12735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRD51_RS12745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRD51_RS12760	COG1799	cell septum assembly
HRD51_RS12785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRD51_RS12795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRD51_RS12800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD51_RS12810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRD51_RS12815	COG0768	penicillin binding
HRD51_RS12825	COG0275	rRNA processing
HRD51_RS12835	COG0714	Associated with various cellular activities
HRD51_RS12855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD51_RS12875	COG1309	transcriptional regulator
HRD51_RS12885	COG1233	COG1233 Phytoene dehydrogenase and related
HRD51_RS12900	COG0352	thiamine-phosphate diphosphorylase activity
HRD51_RS12915	COG2022	thiamine diphosphate biosynthetic process
HRD51_RS12915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD51_RS12925	COG2022	thiamine diphosphate biosynthetic process
HRD51_RS12935	COG2815	serine threonine protein kinase
HRD51_RS12935	COG0515	serine threonine protein kinase
HRD51_RS12940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRD51_RS12945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HRD51_RS12950	COG2193	ferroxidase activity
HRD51_RS12955	COG0243	molybdopterin cofactor binding
HRD51_RS12960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRD51_RS12970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD51_RS12975	COG0205	6-phosphofructokinase activity
HRD51_RS12980	COG2197	response regulator
HRD51_RS13010	COG1940	carbohydrate kinase activity
HRD51_RS13020	COG0003	Pfam Anion-transporting ATPase
HRD51_RS13040	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS13085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD51_RS13090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD51_RS13095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRD51_RS13100	COG0723	plastoquinol--plastocyanin reductase activity
HRD51_RS13105	COG2010	Cytochrome c
HRD51_RS13110	COG1845	cytochrome c oxidase, subunit III
HRD51_RS13120	COG1376	ErfK ybiS ycfS ynhG family protein
HRD51_RS13130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD51_RS13135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRD51_RS13145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD51_RS13160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HRD51_RS13165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD51_RS13170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HRD51_RS13175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD51_RS13180	COG2197	response regulator
HRD51_RS13185	COG4585	Histidine kinase
HRD51_RS13220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRD51_RS13225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HRD51_RS13225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRD51_RS13240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRD51_RS13245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD51_RS13250	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD51_RS13260	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRD51_RS13285	COG1090	epimerase
HRD51_RS13300	COG0321	lipoyl(octanoyl) transferase activity
HRD51_RS13305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRD51_RS13415	COG0745	RESPONSE REGULATOR receiver
HRD51_RS13495	COG0366	Alpha amylase catalytic
HRD51_RS13500	COG3833	ABC-type maltose transport systems, permease component
HRD51_RS13505	COG1175	transmembrane transport
HRD51_RS13515	COG0366	Alpha amylase catalytic
HRD51_RS13520	COG1609	Transcriptional regulator
HRD51_RS13530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRD51_RS13535	COG0174	glutamine synthetase
HRD51_RS13550	COG2132	Multicopper oxidase
HRD51_RS13555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD51_RS13555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD51_RS13560	COG2814	Major facilitator Superfamily
HRD51_RS13570	COG1309	transcriptional regulator
HRD51_RS13575	COG0477	Major facilitator Superfamily
HRD51_RS13580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRD51_RS13600	COG1994	Peptidase M50
HRD51_RS13620	COG1175	transmembrane transport
HRD51_RS13630	COG2186	Transcriptional regulator
HRD51_RS13635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD51_RS13655	COG5398	heme oxygenase
HRD51_RS13685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD51_RS13690	COG2814	Major facilitator Superfamily
HRD51_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS13735	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS13765	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS13770	COG1316	TRANSCRIPTIONal
HRD51_RS13835	COG3022	response to hydroperoxide
HRD51_RS13840	COG0800	Aldolase
HRD51_RS13855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRD51_RS13860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD51_RS13885	COG2030	dehydratase
HRD51_RS13890	COG1131	(ABC) transporter
HRD51_RS13900	COG4585	Histidine kinase
HRD51_RS13905	COG2197	response regulator
HRD51_RS13915	COG0183	Belongs to the thiolase family
HRD51_RS13920	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS13940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS13965	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS14025	COG3845	ABC transporter
HRD51_RS14040	COG1476	TRANSCRIPTIONal
HRD51_RS14045	COG0183	Belongs to the thiolase family
HRD51_RS14050	COG2124	cytochrome p450
HRD51_RS14060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD51_RS14115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD51_RS14160	COG1072	(Pantothenic acid kinase))
HRD51_RS14175	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD51_RS14220	COG2186	Transcriptional regulator
HRD51_RS14225	COG4948	Mandelate Racemase Muconate Lactonizing
HRD51_RS14250	COG1358	cellular component organization or biogenesis
HRD51_RS14295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRD51_RS14305	COG0477	Major facilitator Superfamily
HRD51_RS14310	COG1309	transcriptional regulator
HRD51_RS14325	COG4585	Histidine kinase
HRD51_RS14330	COG2197	response regulator
HRD51_RS14345	COG0667	Aldo Keto reductase
HRD51_RS14350	COG0789	Transcriptional regulator
HRD51_RS14375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRD51_RS14380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS14385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS14425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD51_RS14435	COG1129	ABC transporter
HRD51_RS14440	COG1609	Transcriptional regulator
HRD51_RS14445	COG1764	response to oxidative stress
HRD51_RS14455	COG2130	NADP-dependent
HRD51_RS14465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HRD51_RS14470	COG0477	Major facilitator Superfamily
HRD51_RS14500	COG0500	methyltransferase
HRD51_RS14505	COG4981	capsule polysaccharide biosynthetic process
HRD51_RS14540	COG1077	Cell shape determining protein MreB Mrl
HRD51_RS14545	COG0588	phosphoglycerate mutase activity
HRD51_RS14550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD51_RS14600	COG0477	Major facilitator Superfamily
HRD51_RS14605	COG2378	regulation of single-species biofilm formation
HRD51_RS14635	COG2814	Major facilitator Superfamily
HRD51_RS14650	COG3547	Transposase (IS116 IS110 IS902 family)
HRD51_RS14685	COG1309	transcriptional regulator
HRD51_RS14725	COG1070	Carbohydrate kinase
HRD51_RS14735	COG0358	DNA primase activity
HRD51_RS14750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRD51_RS14760	COG0243	molybdopterin cofactor binding
HRD51_RS14765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD51_RS14780	COG2949	membrane
HRD51_RS14800	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HRD51_RS14810	COG0667	Aldo Keto reductase
HRD51_RS14835	COG1473	amidohydrolase
HRD51_RS14845	COG2197	response regulator
HRD51_RS14855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD51_RS14860	COG2146	nitrite reductase [NAD(P)H] activity
HRD51_RS14860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD51_RS14875	COG0531	amino acid
HRD51_RS14885	COG2182	Extracellular solute-binding protein
HRD51_RS14890	COG1175	transmembrane transport
HRD51_RS14895	COG0395	ABC-type sugar transport system, permease component
HRD51_RS14930	COG2175	clavaminate synthase activity
HRD51_RS14945	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS14955	COG0535	radical SAM domain protein
HRD51_RS14975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD51_RS14975	COG0574	Belongs to the PEP-utilizing enzyme family
HRD51_RS14985	COG0477	Major facilitator Superfamily
HRD51_RS15010	COG0477	Major facilitator Superfamily
HRD51_RS15015	COG0667	Aldo Keto reductase
HRD51_RS15025	COG0423	glycine-tRNA ligase activity
HRD51_RS15030	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD51_RS15030	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRD51_RS15035	COG1121	(ABC) transporter
HRD51_RS15040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD51_RS15050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRD51_RS15055	COG1381	Involved in DNA repair and RecF pathway recombination
HRD51_RS15115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD51_RS15135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRD51_RS15150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRD51_RS15165	COG1486	melibiose metabolic process
HRD51_RS15180	COG4948	Mandelate Racemase Muconate Lactonizing
HRD51_RS15190	COG1234	tRNA 3'-trailer cleavage
HRD51_RS15195	COG0537	adenosine 5'-monophosphoramidase activity
HRD51_RS15215	COG0484	heat shock protein binding
HRD51_RS15220	COG1420	regulation of RNA biosynthetic process
HRD51_RS15250	COG1022	Amp-dependent synthetase and ligase
HRD51_RS15255	COG0481	GTPase activity
HRD51_RS15260	COG0268	Binds directly to 16S ribosomal RNA
HRD51_RS15280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HRD51_RS15285	COG1234	tRNA 3'-trailer cleavage
HRD51_RS15290	COG1555	photosystem II stabilization
HRD51_RS15295	COG1307	EDD domain protein, DegV family
HRD51_RS15305	COG0495	leucyl-tRNA aminoacylation
HRD51_RS15335	COG0588	phosphoglycerate mutase activity
HRD51_RS15340	COG0799	negative regulation of ribosome biogenesis
HRD51_RS15350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRD51_RS15365	COG0501	Belongs to the peptidase M48B family
HRD51_RS15380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRD51_RS15390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRD51_RS15400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRD51_RS15405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRD51_RS15410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRD51_RS15415	COG1530	ribonuclease E activity
HRD51_RS15440	COG0772	Belongs to the SEDS family
HRD51_RS15445	COG0768	penicillin binding
HRD51_RS15460	COG1077	Cell shape determining protein MreB Mrl
HRD51_RS15465	COG0105	UTP biosynthetic process
HRD51_RS15475	COG0285	dihydrofolate synthase activity
HRD51_RS15480	COG0768	penicillin binding
HRD51_RS15490	COG0525	valine-tRNA ligase activity
HRD51_RS15500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRD51_RS15505	COG0740	serine-type endopeptidase activity
HRD51_RS15510	COG0740	serine-type endopeptidase activity
HRD51_RS15515	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRD51_RS15540	COG0475	glutathione-regulated potassium exporter activity
HRD51_RS15550	COG4552	Acetyltransferase involved in intracellular survival and related
HRD51_RS15565	COG1113	amino acid transport
HRD51_RS15575	COG1113	amino acid transport
HRD51_RS15580	COG1113	amino acid transport
HRD51_RS15585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRD51_RS15590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HRD51_RS15620	COG4266	Belongs to the allantoicase family
HRD51_RS15625	COG0583	DNA-binding transcription factor activity
HRD51_RS15665	COG0668	transmembrane transport
HRD51_RS15675	COG1940	carbohydrate kinase activity
HRD51_RS15675	COG1846	Transcriptional regulator
HRD51_RS15680	COG1653	transport
HRD51_RS15685	COG1175	transmembrane transport
HRD51_RS15690	COG0395	ABC-type sugar transport system, permease component
HRD51_RS15710	COG2186	Transcriptional regulator
HRD51_RS15720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD51_RS15805	COG0629	single-stranded DNA binding
HRD51_RS15875	COG4585	Histidine kinase
HRD51_RS15880	COG2197	response regulator
HRD51_RS15885	COG0745	RESPONSE REGULATOR receiver
HRD51_RS15890	COG2205	protein histidine kinase activity
HRD51_RS15895	COG1136	(ABC) transporter
HRD51_RS15900	COG0577	efflux transmembrane transporter activity
HRD51_RS15900	COG1136	(ABC) transporter
HRD51_RS15910	COG1136	(ABC) transporter
HRD51_RS15910	COG0577	efflux transmembrane transporter activity
HRD51_RS15920	COG4585	Histidine kinase
HRD51_RS15925	COG2226	methyltransferase
HRD51_RS15930	COG2197	response regulator
HRD51_RS15940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS15980	COG1077	Cell shape determining protein MreB Mrl
HRD51_RS15990	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HRD51_RS16005	COG1131	(ABC) transporter
HRD51_RS16020	COG3962	Belongs to the TPP enzyme family
HRD51_RS16025	COG3718	enzyme involved in inositol metabolism
HRD51_RS16045	COG0673	inositol 2-dehydrogenase activity
HRD51_RS16050	COG2814	Major facilitator Superfamily
HRD51_RS16070	COG0673	inositol 2-dehydrogenase activity
HRD51_RS16090	COG2608	mercury ion transmembrane transporter activity
HRD51_RS16100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRD51_RS16115	COG0673	inositol 2-dehydrogenase activity
HRD51_RS16125	COG1472	Belongs to the glycosyl hydrolase 3 family
HRD51_RS16155	COG0488	(ABC) transporter
HRD51_RS16175	COG1554	hydrolase, family 65, central catalytic
HRD51_RS16190	COG1309	transcriptional regulator
HRD51_RS16240	COG1946	Acyl-CoA thioesterase
HRD51_RS16245	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS16250	COG1309	transcriptional regulator
HRD51_RS16255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRD51_RS16270	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS16305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRD51_RS16320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRD51_RS16325	COG0589	response to stress
HRD51_RS16330	COG4977	sequence-specific DNA binding
HRD51_RS16335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRD51_RS16345	COG2910	NAD(P)H-binding
HRD51_RS16355	COG3979	chitinase
HRD51_RS16365	COG0745	RESPONSE REGULATOR receiver
HRD51_RS16395	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS16400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRD51_RS16405	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS16465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS16485	COG0154	amidase activity
HRD51_RS16495	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRD51_RS16500	COG0765	amino acid transport
HRD51_RS16505	COG0765	amino acid transport
HRD51_RS16510	COG1126	abc transporter atp-binding protein
HRD51_RS16525	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS16530	COG2318	DinB family
HRD51_RS16590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD51_RS16595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD51_RS16600	COG2188	Transcriptional regulator
HRD51_RS16605	COG1940	carbohydrate kinase activity
HRD51_RS16610	COG0673	inositol 2-dehydrogenase activity
HRD51_RS16615	COG4702	Belongs to the UPF0303 family
HRD51_RS16620	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRD51_RS16625	COG0706	membrane insertase activity
HRD51_RS16635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD51_RS16645	COG2733	membrane
HRD51_RS16660	COG1131	(ABC) transporter
HRD51_RS16675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD51_RS16685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRD51_RS16700	COG2205	protein histidine kinase activity
HRD51_RS16730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRD51_RS16740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRD51_RS16745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD51_RS16750	COG1263	PTS System
HRD51_RS16755	COG1263	PTS System
HRD51_RS16765	COG1234	tRNA 3'-trailer cleavage
HRD51_RS16790	COG1113	amino acid transport
HRD51_RS16800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRD51_RS16810	COG1335	isochorismatase
HRD51_RS16845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD51_RS16850	COG0222	ribosome binding
HRD51_RS16890	COG0277	FAD linked oxidase domain protein
HRD51_RS16895	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HRD51_RS16905	COG1174	glycine betaine transport
HRD51_RS16910	COG1125	glycine betaine transport
HRD51_RS16910	COG0517	IMP dehydrogenase activity
HRD51_RS16915	COG1174	glycine betaine transport
HRD51_RS16955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRD51_RS16960	COG2080	2 iron, 2 sulfur cluster binding
HRD51_RS16980	COG2814	Major facilitator Superfamily
HRD51_RS16985	COG0583	DNA-binding transcription factor activity
HRD51_RS16995	COG1678	Uncharacterized ACR, COG1678
HRD51_RS17000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRD51_RS17005	COG0776	regulation of translation
HRD51_RS17015	COG3973	AAA domain
HRD51_RS17025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD51_RS17035	COG2223	nitrite transmembrane transporter activity
HRD51_RS17060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRD51_RS17065	COG0793	Belongs to the peptidase S41A family
HRD51_RS17070	COG2177	Part of the ABC transporter FtsEX involved in
HRD51_RS17075	COG2884	Cell division ATP-binding protein ftsE
HRD51_RS17090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HRD51_RS17095	COG0515	serine threonine protein kinase
HRD51_RS17100	COG0515	serine threonine protein kinase
HRD51_RS17110	COG1653	transport
HRD51_RS17115	COG1175	transmembrane transport
HRD51_RS17120	COG0395	ABC-type sugar transport system, permease component
HRD51_RS17165	COG2188	Transcriptional regulator
HRD51_RS17185	COG0463	Glycosyl transferase, family 2
HRD51_RS17205	COG1309	transcriptional regulator
HRD51_RS17215	COG1134	teichoic acid transport
HRD51_RS17215	COG1388	LysM domain
HRD51_RS17220	COG2902	Dehydrogenase
HRD51_RS17225	COG0546	phosphoglycolate phosphatase activity
HRD51_RS17240	COG0653	protein targeting
HRD51_RS17250	COG3214	Protein conserved in bacteria
HRD51_RS17255	COG2197	response regulator
HRD51_RS17260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRD51_RS17270	COG0823	Involved in the tonB-independent uptake of proteins
HRD51_RS17275	COG5002	protein histidine kinase activity
HRD51_RS17275	COG5000	phosphorelay sensor kinase activity
HRD51_RS17280	COG0745	RESPONSE REGULATOR receiver
HRD51_RS17285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRD51_RS17305	COG0714	Associated with various cellular activities
HRD51_RS17345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRD51_RS17355	COG1482	cell wall glycoprotein biosynthetic process
HRD51_RS17365	COG2835	tetraacyldisaccharide 4'-kinase activity
HRD51_RS17370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRD51_RS17405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRD51_RS17410	COG0778	Nitroreductase
HRD51_RS17410	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HRD51_RS17445	COG1316	TRANSCRIPTIONal
HRD51_RS17455	COG1316	TRANSCRIPTIONal
HRD51_RS17475	COG1316	TRANSCRIPTIONal
HRD51_RS17485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HRD51_RS17515	COG2205	protein histidine kinase activity
HRD51_RS17520	COG0745	RESPONSE REGULATOR receiver
HRD51_RS17525	COG3104	oligopeptide transport
HRD51_RS17555	COG1366	Belongs to the anti-sigma-factor antagonist family
HRD51_RS17560	COG1191	sigma factor activity
HRD51_RS17565	COG1228	amidohydrolase
HRD51_RS17575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD51_RS17580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRD51_RS17595	COG1131	(ABC) transporter
HRD51_RS17615	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HRD51_RS17630	COG2755	lipolytic protein G-D-S-L family
HRD51_RS17635	COG0183	Belongs to the thiolase family
HRD51_RS17660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HRD51_RS17665	COG0297	glycogen (starch) synthase activity
HRD51_RS17675	COG1136	(ABC) transporter
HRD51_RS17680	COG0577	efflux transmembrane transporter activity
HRD51_RS17685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD51_RS17710	COG0148	phosphopyruvate hydratase activity
HRD51_RS17715	COG1652	LysM domain
HRD51_RS17725	COG2124	cytochrome p450
HRD51_RS17730	COG0583	DNA-binding transcription factor activity
HRD51_RS17735	COG2814	Major facilitator Superfamily
HRD51_RS17815	COG2814	Major facilitator Superfamily
HRD51_RS17845	COG4585	Histidine kinase
HRD51_RS17855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRD51_RS17860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRD51_RS17865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRD51_RS17870	COG0193	aminoacyl-tRNA hydrolase activity
HRD51_RS17875	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRD51_RS17885	COG1309	transcriptional regulator
HRD51_RS17890	COG4106	trans-aconitate 2-methyltransferase activity
HRD51_RS17910	COG2197	response regulator
HRD51_RS17915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRD51_RS17945	COG0488	(ABC) transporter
HRD51_RS17975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRD51_RS17980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRD51_RS17990	COG0084	hydrolase, TatD family'
HRD51_RS18035	COG1122	ATPase activity
HRD51_RS18045	COG0310	cobalt ion transport
HRD51_RS18050	COG0793	Belongs to the peptidase S41A family
HRD51_RS18050	COG4946	Tricorn protease homolog
HRD51_RS18060	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS18065	COG2267	carboxylic ester hydrolase activity
HRD51_RS18070	COG2072	flavoprotein involved in K transport
HRD51_RS18090	COG0708	Exodeoxyribonuclease III
HRD51_RS18115	COG1725	Transcriptional regulator
HRD51_RS18120	COG2205	protein histidine kinase activity
HRD51_RS18130	COG0789	Transcriptional regulator
HRD51_RS18135	COG1819	glycosyl
HRD51_RS18170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD51_RS18175	COG0315	cyclic pyranopterin monophosphate synthase activity
HRD51_RS18175	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRD51_RS18180	COG0315	cyclic pyranopterin monophosphate synthase activity
HRD51_RS18190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD51_RS18195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRD51_RS18205	COG3263	regulation of cellular component size
HRD51_RS18220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRD51_RS18230	COG1970	mechanosensitive ion channel activity
HRD51_RS18240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD51_RS18250	COG2188	Transcriptional regulator
HRD51_RS18290	COG3191	aminopeptidase activity
HRD51_RS18310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRD51_RS18320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD51_RS18335	COG1349	DNA-binding transcription factor activity
HRD51_RS18345	COG1247	-acetyltransferase
HRD51_RS18365	COG1846	Transcriptional regulator
HRD51_RS18385	COG1309	transcriptional regulator
HRD51_RS18410	COG0514	ATP-dependent DNA helicase (RecQ)
HRD51_RS18415	COG2205	protein histidine kinase activity
HRD51_RS18435	COG0640	Transcriptional regulator
HRD51_RS18445	COG1686	Belongs to the peptidase S11 family
HRD51_RS18465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD51_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS18495	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HRD51_RS18565	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS18590	COG1024	Enoyl-CoA hydratase
HRD51_RS18610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD51_RS18610	COG0515	serine threonine protein kinase
HRD51_RS18615	COG1309	transcriptional regulator
HRD51_RS18625	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS18640	COG0259	pyridoxamine-phosphate oxidase activity
HRD51_RS18655	COG1042	CoA-binding domain protein
HRD51_RS18655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD51_RS18655	COG0045	succinate-CoA ligase (ADP-forming) activity
HRD51_RS18660	COG1024	Enoyl-CoA hydratase
HRD51_RS18675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRD51_RS18690	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS18705	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS18710	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS18715	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS18735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD51_RS18745	COG0516	GMP reductase activity
HRD51_RS18755	COG1595	DNA-templated transcription, initiation
HRD51_RS18760	COG2197	response regulator
HRD51_RS18770	COG0583	DNA-binding transcription factor activity
HRD51_RS18780	COG4221	oxidoreductase activity
HRD51_RS18785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD51_RS18790	COG0459	protein refolding
HRD51_RS18795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRD51_RS18800	COG0772	Belongs to the SEDS family
HRD51_RS18815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRD51_RS18840	COG0802	atpase or kinase
HRD51_RS18850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRD51_RS18860	COG0736	holo-[acyl-carrier-protein] synthase activity
HRD51_RS18865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRD51_RS18875	COG1072	(Pantothenic acid kinase))
HRD51_RS18880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRD51_RS18885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRD51_RS18890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRD51_RS18900	COG0101	tRNA pseudouridine synthase activity
HRD51_RS18905	COG0203	ribosomal protein L17
HRD51_RS18910	COG0202	RNA polymerase activity
HRD51_RS18915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRD51_RS18920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRD51_RS18925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRD51_RS18930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD51_RS18935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRD51_RS18945	COG0563	adenylate kinase activity
HRD51_RS18955	COG0200	Binds to the 23S rRNA
HRD51_RS18960	COG1841	ribosomal large subunit assembly
HRD51_RS18965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRD51_RS18970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRD51_RS18975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRD51_RS18980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRD51_RS18985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRD51_RS18990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRD51_RS18995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRD51_RS19000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRD51_RS19005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRD51_RS19010	COG0255	Belongs to the universal ribosomal protein uL29 family
HRD51_RS19015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRD51_RS19020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRD51_RS19025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRD51_RS19030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRD51_RS19035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRD51_RS19040	COG0089	rRNA binding
HRD51_RS19045	COG0088	Forms part of the polypeptide exit tunnel
HRD51_RS19050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRD51_RS19055	COG0051	transcription antitermination factor activity, RNA binding
HRD51_RS19060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD51_RS19065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRD51_RS19070	COG0049	tRNA binding
HRD51_RS19075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRD51_RS19085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRD51_RS19090	COG0085	RNA polymerase activity
HRD51_RS19095	COG0222	ribosome binding
HRD51_RS19110	COG0081	regulation of translation
HRD51_RS19115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRD51_RS19120	COG0250	Participates in transcription elongation, termination and antitermination
HRD51_RS19135	COG0436	Aminotransferase
HRD51_RS19140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD51_RS19145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRD51_RS19155	COG2030	dehydratase
HRD51_RS19160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRD51_RS19180	COG0702	epimerase
HRD51_RS19195	COG1666	GTP binding
HRD51_RS19205	COG3304	Inner membrane component domain
HRD51_RS19210	COG0501	Belongs to the peptidase M48B family
HRD51_RS19215	COG1007	ATP synthesis coupled electron transport
HRD51_RS19230	COG0713	ATP synthesis coupled electron transport
HRD51_RS19240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD51_RS19245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRD51_RS19250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD51_RS19255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD51_RS19260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD51_RS19280	COG4585	Histidine kinase
HRD51_RS19290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRD51_RS19290	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRD51_RS19295	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRD51_RS19320	COG0142	geranyltranstransferase activity
HRD51_RS19335	COG1007	ATP synthesis coupled electron transport
HRD51_RS19345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD51_RS19350	COG0713	ATP synthesis coupled electron transport
HRD51_RS19355	COG0839	Belongs to the complex I subunit 6 family
HRD51_RS19360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD51_RS19365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRD51_RS19370	COG1034	ATP synthesis coupled electron transport
HRD51_RS19375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HRD51_RS19385	COG0649	NAD binding
HRD51_RS19390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD51_RS19395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD51_RS19440	COG2226	methyltransferase
HRD51_RS19450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HRD51_RS19460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HRD51_RS19465	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HRD51_RS19470	COG1278	Cold shock
HRD51_RS19490	COG1309	transcriptional regulator
HRD51_RS19500	COG1301	dicarboxylic acid transport
HRD51_RS19515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HRD51_RS19525	COG0163	prenyltransferase activity
HRD51_RS19540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRD51_RS19545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRD51_RS19575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD51_RS19580	COG1333	cytochrome c biogenesis protein
HRD51_RS19585	COG0785	Cytochrome C biogenesis protein
HRD51_RS19600	COG0406	alpha-ribazole phosphatase activity
HRD51_RS19605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRD51_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS19635	COG1742	UPF0060 membrane protein
HRD51_RS19660	COG1846	Transcriptional regulator
HRD51_RS19665	COG1690	Belongs to the RtcB family
HRD51_RS19690	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HRD51_RS19695	COG0018	arginyl-trna synthetase
HRD51_RS19705	COG0667	Aldo Keto reductase
HRD51_RS19715	COG0113	porphobilinogen synthase activity
HRD51_RS19720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD51_RS19720	COG1648	precorrin-2 dehydrogenase activity
HRD51_RS19725	COG0181	hydroxymethylbilane synthase activity
HRD51_RS19730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRD51_RS19735	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HRD51_RS19785	COG0123	including yeast histone deacetylase and acetoin utilization protein
HRD51_RS19795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD51_RS19855	COG0579	oxidoreductase
HRD51_RS19860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRD51_RS19935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRD51_RS19950	COG2814	Major facilitator Superfamily
HRD51_RS19965	COG0513	Belongs to the DEAD box helicase family
HRD51_RS20000	COG1643	Atp-dependent helicase
HRD51_RS20035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRD51_RS20050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRD51_RS20055	COG0047	phosphoribosylformylglycinamidine synthase activity
HRD51_RS20060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRD51_RS20085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRD51_RS20095	COG0583	DNA-binding transcription factor activity
HRD51_RS20110	COG0151	Belongs to the GarS family
HRD51_RS20125	COG1802	Transcriptional regulator
HRD51_RS20130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRD51_RS20140	COG0515	serine threonine protein kinase
HRD51_RS20140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD51_RS20145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRD51_RS20160	COG1131	(ABC) transporter
HRD51_RS20165	COG3559	Exporter of polyketide antibiotics
HRD51_RS20170	COG2197	response regulator
HRD51_RS20175	COG4585	Histidine kinase
HRD51_RS20185	COG3844	kynureninase activity
HRD51_RS20200	COG0477	Major facilitator Superfamily
HRD51_RS20205	COG0191	fructose-bisphosphate aldolase activity
HRD51_RS20210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRD51_RS20225	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRD51_RS20250	COG0542	response to heat
HRD51_RS20270	COG0789	Transcriptional regulator
HRD51_RS20275	COG0484	heat shock protein binding
HRD51_RS20280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRD51_RS20285	COG0443	Heat shock 70 kDa protein
HRD51_RS20290	COG0247	lactate metabolic process
HRD51_RS20290	COG2181	nitrate reductase activity
HRD51_RS20310	COG0717	Belongs to the dCTP deaminase family
HRD51_RS20360	COG0477	Major facilitator Superfamily
HRD51_RS20380	COG2301	Belongs to the HpcH HpaI aldolase family
HRD51_RS20400	COG0662	Cupin 2, conserved barrel domain protein
HRD51_RS20480	COG1316	TRANSCRIPTIONal
HRD51_RS20545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRD51_RS20570	COG0517	IMP dehydrogenase activity
HRD51_RS20570	COG1125	glycine betaine transport
HRD51_RS20580	COG1174	glycine betaine transport
HRD51_RS20585	COG1174	glycine betaine transport
HRD51_RS20605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD51_RS20610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRD51_RS20635	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS20640	COG1362	aminopeptidase activity
HRD51_RS20645	COG3903	Transcriptional regulator
HRD51_RS20645	COG3629	intracellular signal transduction
HRD51_RS20690	COG0494	nUDIX hydrolase
HRD51_RS20720	COG0022	dehydrogenase e1 component
HRD51_RS20745	COG0515	serine threonine protein kinase
HRD51_RS20750	COG0515	serine threonine protein kinase
HRD51_RS20770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD51_RS20780	COG0746	molybdenum cofactor guanylyltransferase activity
HRD51_RS20800	COG1522	sequence-specific DNA binding
HRD51_RS20805	COG1309	transcriptional regulator
HRD51_RS20810	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD51_RS20850	COG3396	Phenylacetate-CoA oxygenase
HRD51_RS20855	COG3460	Phenylacetate-CoA oxygenase
HRD51_RS20860	COG3396	Phenylacetate-CoA oxygenase
HRD51_RS20865	COG2151	metal-sulfur cluster biosynthetic enzyme
HRD51_RS20870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD51_RS20905	COG1733	regulation of RNA biosynthetic process
HRD51_RS20910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRD51_RS20915	COG2814	Major facilitator Superfamily
HRD51_RS20920	COG0583	DNA-binding transcription factor activity
HRD51_RS20930	COG1716	ATPase activity
HRD51_RS20935	COG1716	ATPase activity
HRD51_RS20950	COG0768	penicillin binding
HRD51_RS20955	COG0515	serine threonine protein kinase
HRD51_RS20960	COG3764	Sortase (surface protein transpeptidase)
HRD51_RS20980	COG3764	Sortase (surface protein transpeptidase)
HRD51_RS20995	COG0705	Rhomboid family
HRD51_RS21010	COG0583	DNA-binding transcription factor activity
HRD51_RS21030	COG0515	serine threonine protein kinase
HRD51_RS21055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRD51_RS21060	COG0187	DNA topoisomerase II activity
HRD51_RS21065	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HRD51_RS21070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRD51_RS21075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HRD51_RS21080	COG0592	DNA-directed DNA polymerase activity
HRD51_RS21090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRD51_RS21095	COG0594	ribonuclease P activity
HRD51_RS21100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRD51_RS21105	COG0706	membrane insertase activity
HRD51_RS21115	COG0357	Ribosomal RNA small subunit methyltransferase G
HRD51_RS21120	COG1192	Involved in chromosome partitioning
HRD51_RS21135	COG3118	belongs to the thioredoxin family
HRD51_RS21140	COG0492	ferredoxin-NADP+ reductase activity
HRD51_RS21150	COG1595	DNA-templated transcription, initiation
HRD51_RS21155	COG2815	serine threonine protein kinase
HRD51_RS21155	COG0515	serine threonine protein kinase
HRD51_RS21160	COG0728	peptidoglycan biosynthetic process
HRD51_RS21170	COG0617	tRNA 3'-terminal CCA addition
HRD51_RS21185	COG1260	myo-inositol-1-phosphate synthase
HRD51_RS21195	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRD51_RS21220	COG0360	Binds together with S18 to 16S ribosomal RNA
HRD51_RS21225	COG0629	single-stranded DNA binding
HRD51_RS21230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRD51_RS21235	COG0359	binds to the 23S rRNA
HRD51_RS21245	COG0534	Mate efflux family protein
HRD51_RS21250	COG0305	Participates in initiation and elongation during chromosome replication
HRD51_RS21255	COG1309	transcriptional regulator
HRD51_RS21265	COG0789	Transcriptional regulator
HRD51_RS21265	COG4978	Transcriptional regulator
HRD51_RS21275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD51_RS21280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HRD51_RS21300	COG2814	Major facilitator Superfamily
HRD51_RS21335	COG0626	cystathionine gamma-synthase activity
HRD51_RS21340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRD51_RS21345	COG1950	PFAM Membrane protein of
HRD51_RS21350	COG0662	Cupin 2, conserved barrel domain protein
HRD51_RS21375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRD51_RS21385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD51_RS21390	COG1609	Transcriptional regulator
HRD51_RS21395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD51_RS21405	COG1271	oxidase subunit
HRD51_RS21410	COG1294	oxidase, subunit
HRD51_RS21415	COG4988	ABC transporter
HRD51_RS21425	COG0561	phosphatase activity
HRD51_RS21435	COG0501	Belongs to the peptidase M48B family
HRD51_RS21445	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HRD51_RS21460	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HRD51_RS21465	COG0789	Transcriptional regulator
HRD51_RS21510	COG2807	transmembrane transport
HRD51_RS21515	COG2186	Transcriptional regulator
HRD51_RS21555	COG0561	phosphatase activity
HRD51_RS21560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRD51_RS21570	COG2837	iron assimilation
HRD51_RS21575	COG2372	response to copper ion
HRD51_RS21605	COG0582	viral genome integration into host DNA
HRD51_RS21635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD51_RS21665	COG0242	peptide deformylase activity
HRD51_RS21710	COG0006	proline dipeptidase activity
HRD51_RS21730	COG0653	protein targeting
HRD51_RS21745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD51_RS21755	COG0494	nUDIX hydrolase
HRD51_RS21810	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS21820	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS21845	COG1595	DNA-templated transcription, initiation
HRD51_RS21870	COG2318	DinB family
HRD51_RS21875	COG3437	response regulator, receiver
HRD51_RS21890	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS21895	COG5000	phosphorelay sensor kinase activity
HRD51_RS21915	COG4977	sequence-specific DNA binding
HRD51_RS21955	COG1053	succinate dehydrogenase
HRD51_RS21955	COG3976	FMN-binding domain protein
HRD51_RS21955	COG0431	NADPH-dependent FMN reductase
HRD51_RS21960	COG0745	RESPONSE REGULATOR receiver
HRD51_RS21965	COG2205	protein histidine kinase activity
HRD51_RS21975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD51_RS21980	COG0477	Major facilitator Superfamily
HRD51_RS22000	COG2353	YceI-like domain
HRD51_RS22035	COG1191	sigma factor activity
HRD51_RS22040	COG1191	sigma factor activity
HRD51_RS22070	COG0590	tRNA wobble adenosine to inosine editing
HRD51_RS22080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRD51_RS22110	COG0523	cobalamin synthesis protein
HRD51_RS22120	COG1064	alcohol dehydrogenase
HRD51_RS22145	COG2268	Band 7 protein
HRD51_RS22155	COG0477	Major facilitator Superfamily
HRD51_RS22235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD51_RS22240	COG1834	amidinotransferase
HRD51_RS22250	COG2188	Transcriptional regulator
HRD51_RS22255	COG0477	Major facilitator Superfamily
HRD51_RS22260	COG0402	S-adenosylhomocysteine deaminase activity
HRD51_RS22280	COG2172	sigma factor antagonist activity
HRD51_RS22280	COG2208	phosphoserine phosphatase activity
HRD51_RS22280	COG1366	Belongs to the anti-sigma-factor antagonist family
HRD51_RS22295	COG1132	(ABC) transporter
HRD51_RS22330	COG2188	Transcriptional regulator
HRD51_RS22340	COG3328	transposase activity
HRD51_RS22370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRD51_RS22380	COG2217	Heavy metal translocating P-type atpase
HRD51_RS22440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRD51_RS22445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRD51_RS22465	COG1595	DNA-templated transcription, initiation
HRD51_RS22495	COG0339	signal peptide processing
HRD51_RS22510	COG1408	metallophosphoesterase
HRD51_RS22520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD51_RS22530	COG0003	Pfam Anion-transporting ATPase
HRD51_RS22555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD51_RS22590	COG2267	carboxylic ester hydrolase activity
HRD51_RS22600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD51_RS22605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD51_RS22670	COG1205	dead DEAH box helicase
HRD51_RS22670	COG1111	helicase
HRD51_RS22675	COG1366	Belongs to the anti-sigma-factor antagonist family
HRD51_RS22685	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HRD51_RS22695	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD51_RS22715	COG1754	DNA topoisomerase type I activity
HRD51_RS22715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD51_RS22720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRD51_RS22725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRD51_RS22815	COG2226	methyltransferase
HRD51_RS22820	COG2124	cytochrome p450
HRD51_RS22835	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS22860	COG0584	glycerophosphoryl diester phosphodiesterase
HRD51_RS22865	COG3594	Acyltransferase
HRD51_RS22880	COG1349	DNA-binding transcription factor activity
HRD51_RS22930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD51_RS22930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD51_RS22940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRD51_RS22945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRD51_RS22950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRD51_RS22955	COG0254	rRNA binding
HRD51_RS22965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRD51_RS22970	COG0640	Transcriptional regulator
HRD51_RS22995	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS23000	COG2318	DinB family
HRD51_RS23010	COG0076	glutamate decarboxylase activity
HRD51_RS23015	COG0655	NAD(P)H dehydrogenase (quinone) activity
HRD51_RS23025	COG0393	Putative heavy-metal-binding
HRD51_RS23040	COG1132	(ABC) transporter
HRD51_RS23050	COG2226	methyltransferase
HRD51_RS23085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRD51_RS23090	COG2027	D-alanyl-D-alanine carboxypeptidase
HRD51_RS23100	COG0037	tRNA processing
HRD51_RS23115	COG0302	gtp cyclohydrolase
HRD51_RS23140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRD51_RS23145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRD51_RS23160	COG1174	glycine betaine transport
HRD51_RS23165	COG1174	glycine betaine transport
HRD51_RS23180	COG0649	NAD binding
HRD51_RS23195	COG2197	response regulator
HRD51_RS23205	COG0640	Transcriptional regulator
HRD51_RS23215	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HRD51_RS23225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRD51_RS23230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRD51_RS23240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRD51_RS23260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRD51_RS23320	COG2205	protein histidine kinase activity
HRD51_RS23325	COG0745	RESPONSE REGULATOR receiver
HRD51_RS23335	COG1595	DNA-templated transcription, initiation
HRD51_RS23340	COG1194	a g-specific adenine glycosylase
HRD51_RS23360	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HRD51_RS23380	COG0248	Ppx GppA phosphatase
HRD51_RS23385	COG1082	Xylose isomerase domain protein TIM barrel
HRD51_RS23390	COG0129	dihydroxy-acid dehydratase activity
HRD51_RS23405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD51_RS23405	COG0515	serine threonine protein kinase
HRD51_RS23430	COG1595	DNA-templated transcription, initiation
HRD51_RS23435	COG0308	aminopeptidase N
HRD51_RS23440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRD51_RS23445	COG0180	Tryptophanyl-tRNA synthetase
HRD51_RS23485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD51_RS23490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS23495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS23505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS23520	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS23565	COG0739	heme binding
HRD51_RS23565	COG1196	nuclear chromosome segregation
HRD51_RS23565	COG0741	lytic transglycosylase activity
HRD51_RS23570	COG0671	phosphoesterase, PA-phosphatase related
HRD51_RS23575	COG0277	FAD linked oxidase domain protein
HRD51_RS23595	COG1937	Protein conserved in bacteria
HRD51_RS23605	COG0306	phosphate transporter
HRD51_RS23625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRD51_RS23660	COG0754	glutathionylspermidine amidase activity
HRD51_RS23665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRD51_RS23675	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD51_RS23690	COG0667	Aldo Keto reductase
HRD51_RS23710	COG1733	regulation of RNA biosynthetic process
HRD51_RS23715	COG0431	NADPH-dependent FMN reductase
HRD51_RS23735	COG1490	D-aminoacyl-tRNA deacylase activity
HRD51_RS23755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD51_RS23760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS23765	COG3485	protocatechuate 3,4-dioxygenase
HRD51_RS23785	COG2897	thiosulfate sulfurtransferase activity
HRD51_RS23815	COG0745	RESPONSE REGULATOR receiver
HRD51_RS23820	COG1609	Transcriptional regulator
HRD51_RS23825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD51_RS23830	COG0745	RESPONSE REGULATOR receiver
HRD51_RS23835	COG2205	protein histidine kinase activity
HRD51_RS23865	COG0737	Belongs to the 5'-nucleotidase family
HRD51_RS23870	COG0456	acetyltransferase
HRD51_RS23875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD51_RS23880	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRD51_RS23890	COG0406	alpha-ribazole phosphatase activity
HRD51_RS23890	COG0494	nUDIX hydrolase
HRD51_RS23905	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS23935	COG0588	phosphoglycerate mutase activity
HRD51_RS23945	COG5002	protein histidine kinase activity
HRD51_RS23960	COG1329	Transcriptional regulator
HRD51_RS23965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRD51_RS23970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRD51_RS23980	COG0215	cysteine-tRNA ligase activity
HRD51_RS23995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRD51_RS24005	COG3842	ATPase activity
HRD51_RS24065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRD51_RS24090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD51_RS24120	COG3336	cytochrome c oxidase
HRD51_RS24130	COG0463	Glycosyl transferase, family 2
HRD51_RS24145	COG1278	Cold shock
HRD51_RS24165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD51_RS24165	COG1263	PTS System
HRD51_RS24170	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRD51_RS24200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD51_RS24215	COG3142	Participates in the control of copper homeostasis
HRD51_RS24230	COG3973	AAA domain
HRD51_RS24245	COG1061	Type III restriction enzyme res subunit
HRD51_RS24250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRD51_RS24270	COG3328	transposase activity
HRD51_RS24290	COG1278	Cold shock
HRD51_RS24320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD51_RS24325	COG1120	ATPase activity
HRD51_RS24330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS24335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD51_RS24355	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HRD51_RS24360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD51_RS24370	COG2814	Major facilitator Superfamily
HRD51_RS24390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD51_RS24395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRD51_RS24405	COG2252	PERMEase
HRD51_RS24430	COG0667	Aldo Keto reductase
HRD51_RS24455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRD51_RS24475	COG0277	FAD linked oxidase domain protein
HRD51_RS24475	COG0247	lactate metabolic process
HRD51_RS24485	COG5006	permease, DMT superfamily
HRD51_RS24515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRD51_RS24530	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS24540	COG1309	transcriptional regulator
HRD51_RS24550	COG0259	pyridoxamine-phosphate oxidase activity
HRD51_RS24560	COG4821	SIS domain
HRD51_RS24570	COG2945	thiolester hydrolase activity
HRD51_RS24570	COG0596	Alpha beta hydrolase
HRD51_RS24590	COG0477	Major facilitator Superfamily
HRD51_RS24600	COG1131	(ABC) transporter
HRD51_RS24685	COG0515	serine threonine protein kinase
HRD51_RS24710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRD51_RS24710	COG0519	Catalyzes the synthesis of GMP from XMP
HRD51_RS24755	COG0515	serine threonine protein kinase
HRD51_RS24765	COG2197	response regulator
HRD51_RS24795	COG0739	heme binding
HRD51_RS24805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD51_RS24820	COG0714	Associated with various cellular activities
HRD51_RS24830	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HRD51_RS24950	COG0045	succinate-CoA ligase (ADP-forming) activity
HRD51_RS24980	COG0138	bifunctional purine biosynthesis protein purh
HRD51_RS24995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRD51_RS25005	COG0538	isocitrate dehydrogenase activity
HRD51_RS25010	COG0039	L-malate dehydrogenase activity
HRD51_RS25045	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS25055	COG4175	Glycine betaine
HRD51_RS25055	COG0517	IMP dehydrogenase activity
HRD51_RS25065	COG4176	ABC-type proline glycine betaine transport system permease component
HRD51_RS25105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRD51_RS25125	COG1295	ribonuclease BN
HRD51_RS25135	COG0180	Tryptophanyl-tRNA synthetase
HRD51_RS25140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRD51_RS25145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD51_RS25270	COG1388	LysM domain
HRD51_RS25270	COG3942	CHAP domain
HRD51_RS25350	COG2188	Transcriptional regulator
HRD51_RS25375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD51_RS25380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD51_RS25385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD51_RS25425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD51_RS25430	COG1053	succinate dehydrogenase
HRD51_RS25440	COG2009	succinate dehydrogenase
HRD51_RS25465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD51_RS25465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD51_RS25480	COG3265	gluconokinase activity
HRD51_RS25520	COG1216	Glycosyl transferase, family 2
HRD51_RS25535	COG2089	acid synthase
HRD51_RS25545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HRD51_RS25545	COG1473	amidohydrolase
HRD51_RS25550	COG1744	ABC transporter substrate-binding protein PnrA-like
HRD51_RS25555	COG3845	ABC transporter
HRD51_RS25560	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRD51_RS25565	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRD51_RS25595	COG2814	Major facilitator Superfamily
HRD51_RS25600	COG0583	DNA-binding transcription factor activity
HRD51_RS25610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD51_RS25635	COG2205	protein histidine kinase activity
HRD51_RS25640	COG0745	RESPONSE REGULATOR receiver
HRD51_RS25645	COG1595	DNA-templated transcription, initiation
HRD51_RS25660	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS25665	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS25680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRD51_RS25715	COG4770	biotin carboxylase activity
HRD51_RS25725	COG0693	protein deglycase activity
HRD51_RS25730	COG0424	maF-like protein
HRD51_RS25735	COG0768	penicillin binding
HRD51_RS25745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRD51_RS25755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRD51_RS25760	COG1024	Enoyl-CoA hydratase
HRD51_RS25770	COG2986	histidine ammonia-lyase
HRD51_RS25840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD51_RS25860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD51_RS25875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD51_RS25885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HRD51_RS26000	COG1472	Belongs to the glycosyl hydrolase 3 family
HRD51_RS26005	COG0667	Aldo Keto reductase
HRD51_RS26010	COG0022	dehydrogenase e1 component
HRD51_RS26015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRD51_RS26030	COG1331	Highly conserved protein containing a thioredoxin domain
HRD51_RS26035	COG2130	NADP-dependent
HRD51_RS26040	COG0154	amidase activity
HRD51_RS26045	COG0789	Transcriptional regulator
HRD51_RS26050	COG1309	transcriptional regulator
HRD51_RS26060	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HRD51_RS26075	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HRD51_RS26090	COG1414	Transcriptional regulator
HRD51_RS26095	COG0251	oxidation-reduction process
HRD51_RS26100	COG2610	gluconate transmembrane transporter activity
HRD51_RS26205	COG0667	Aldo Keto reductase
HRD51_RS26210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRD51_RS26215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HRD51_RS26220	COG0741	lytic transglycosylase activity
HRD51_RS26230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD51_RS26235	COG0450	alkyl hydroperoxide reductase
HRD51_RS26255	COG1136	(ABC) transporter
HRD51_RS26270	COG1136	(ABC) transporter
HRD51_RS26285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD51_RS26310	COG0114	fumarate hydratase activity
HRD51_RS26355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD51_RS26355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD51_RS26380	COG0778	Nitroreductase
HRD51_RS26385	COG1722	exodeoxyribonuclease VII activity
HRD51_RS26390	COG1570	exodeoxyribonuclease VII activity
HRD51_RS26395	COG1113	amino acid transport
HRD51_RS26400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRD51_RS26415	COG0012	GTP binding
HRD51_RS26425	COG1201	RNA secondary structure unwinding
HRD51_RS26480	COG0531	amino acid
HRD51_RS26505	COG0402	S-adenosylhomocysteine deaminase activity
HRD51_RS26515	COG1053	succinate dehydrogenase
HRD51_RS26535	COG1217	gtp-binding protein TYPA
HRD51_RS26540	COG4166	transmembrane transport
HRD51_RS26545	COG0601	transmembrane transport
HRD51_RS26550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD51_RS26555	COG0444	Belongs to the ABC transporter superfamily
HRD51_RS26560	COG4608	Belongs to the ABC transporter superfamily
HRD51_RS26565	COG4608	Belongs to the ABC transporter superfamily
HRD51_RS26570	COG0444	Belongs to the ABC transporter superfamily
HRD51_RS26580	COG0747	negative chemotaxis
HRD51_RS26585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD51_RS26600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HRD51_RS26615	COG1131	(ABC) transporter
HRD51_RS26625	COG4585	Histidine kinase
HRD51_RS26630	COG2197	response regulator
HRD51_RS26670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD51_RS26675	COG1611	Belongs to the LOG family
HRD51_RS26680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRD51_RS26690	COG0519	Catalyzes the synthesis of GMP from XMP
HRD51_RS26695	COG1024	Enoyl-CoA hydratase
HRD51_RS26705	COG4122	O-methyltransferase activity
HRD51_RS26710	COG1595	DNA-templated transcription, initiation
HRD51_RS26720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD51_RS26725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD51_RS26760	COG0598	Magnesium transport protein CorA
HRD51_RS26780	COG2095	MarC family integral membrane protein
HRD51_RS26790	COG1432	Conserved Protein
HRD51_RS26800	COG0513	Belongs to the DEAD box helicase family
HRD51_RS26830	COG0596	Alpha beta hydrolase
HRD51_RS26830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRD51_RS26880	COG0210	DNA helicase
HRD51_RS26890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD51_RS26930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRD51_RS26975	COG3480	Lon protease (S16) C-terminal proteolytic domain
HRD51_RS26985	COG1615	UPF0182 protein
HRD51_RS27010	COG0753	catalase activity
HRD51_RS27020	COG0483	inositol monophosphate 1-phosphatase activity
HRD51_RS27030	COG2076	Multidrug Resistance protein
HRD51_RS27035	COG1162	GTPase activity
HRD51_RS27040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRD51_RS27050	COG2135	peptidase activity
HRD51_RS27060	COG1595	DNA-templated transcription, initiation
HRD51_RS27065	COG5662	AntiSigma factor
HRD51_RS27085	COG0242	peptide deformylase activity
HRD51_RS27090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD51_RS27095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD51_RS27125	COG2188	Transcriptional regulator
HRD51_RS27130	COG2182	Extracellular solute-binding protein
HRD51_RS27135	COG1175	transmembrane transport
HRD51_RS27140	COG0395	ABC-type sugar transport system, permease component
HRD51_RS27150	COG0363	glucosamine-6-phosphate deaminase activity
HRD51_RS27155	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS27160	COG1309	transcriptional regulator
HRD51_RS27175	COG1597	lipid kinase activity
HRD51_RS27210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HRD51_RS27225	COG2066	Belongs to the glutaminase family
HRD51_RS27240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRD51_RS27255	COG0477	Major facilitator Superfamily
HRD51_RS27260	COG0598	Magnesium transport protein CorA
HRD51_RS27265	COG2807	transmembrane transport
HRD51_RS27270	COG2186	Transcriptional regulator
HRD51_RS27275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRD51_RS27280	COG1993	acr, cog1993
HRD51_RS27285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRD51_RS27305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD51_RS27335	COG1126	abc transporter atp-binding protein
HRD51_RS27340	COG0765	amino acid transport
HRD51_RS27345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD51_RS27350	COG0281	malic enzyme
HRD51_RS27355	COG0604	alcohol dehydrogenase
HRD51_RS27390	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD51_RS27390	COG0567	Dehydrogenase, E1 component
HRD51_RS27395	COG2205	protein histidine kinase activity
HRD51_RS27400	COG0745	RESPONSE REGULATOR receiver
HRD51_RS27415	COG1357	PFAM Pentapeptide repeats (8 copies)
HRD51_RS27420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRD51_RS27500	COG1119	ATPase activity
HRD51_RS27505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD51_RS27510	COG0768	penicillin binding
HRD51_RS27520	COG2124	cytochrome p450
HRD51_RS27570	COG0018	arginyl-trna synthetase
HRD51_RS27575	COG0019	diaminopimelate decarboxylase activity
HRD51_RS27580	COG0460	homoserine dehydrogenase
HRD51_RS27585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRD51_RS27590	COG0083	homoserine kinase activity
HRD51_RS27605	COG0254	rRNA binding
HRD51_RS27610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRD51_RS27615	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD51_RS27625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRD51_RS27630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRD51_RS27650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRD51_RS27655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRD51_RS27660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRD51_RS27665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRD51_RS27670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRD51_RS27675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRD51_RS27680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRD51_RS27690	COG2197	response regulator
HRD51_RS27695	COG4585	Histidine kinase
HRD51_RS27710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD51_RS27725	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HRD51_RS27760	COG1131	(ABC) transporter
HRD51_RS27780	COG0183	Belongs to the thiolase family
HRD51_RS27840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD51_RS27840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD51_RS27845	COG2205	protein histidine kinase activity
HRD51_RS27850	COG0745	RESPONSE REGULATOR receiver
HRD51_RS27855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRD51_RS27895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRD51_RS27900	COG0280	phosphate acetyltransferase
HRD51_RS27900	COG0857	belongs to the CobB CobQ family
HRD51_RS27905	COG0205	6-phosphofructokinase activity
HRD51_RS27915	COG0577	efflux transmembrane transporter activity
HRD51_RS27930	COG0395	ABC-type sugar transport system, permease component
HRD51_RS27935	COG1175	transmembrane transport
HRD51_RS27945	COG4565	transcriptional regulatory protein
HRD51_RS27950	COG3290	protein histidine kinase activity
HRD51_RS27955	COG1301	dicarboxylic acid transport
HRD51_RS27965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRD51_RS27975	COG0366	Alpha amylase catalytic
HRD51_RS27980	COG0366	Alpha amylase catalytic
HRD51_RS27995	COG1132	(ABC) transporter
HRD51_RS28000	COG1132	(ABC) transporter
HRD51_RS28015	COG1376	ErfK ybiS ycfS ynhG family protein
HRD51_RS28035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD51_RS28035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD51_RS28040	COG0785	Cytochrome C biogenesis protein
HRD51_RS28050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD51_RS28065	COG0745	RESPONSE REGULATOR receiver
HRD51_RS28085	COG0586	Pfam SNARE associated Golgi protein
HRD51_RS28090	COG0671	phosphoesterase, PA-phosphatase related
HRD51_RS28105	COG1760	l-serine dehydratase
HRD51_RS28110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRD51_RS28115	COG0509	glycine decarboxylation via glycine cleavage system
HRD51_RS28120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRD51_RS28145	COG0747	negative chemotaxis
HRD51_RS28150	COG0601	transmembrane transport
HRD51_RS28155	COG0444	Belongs to the ABC transporter superfamily
HRD51_RS28160	COG4608	Belongs to the ABC transporter superfamily
HRD51_RS28165	COG0308	aminopeptidase N
HRD51_RS28170	COG2860	membrane
HRD51_RS28190	COG0482	sulfurtransferase activity
HRD51_RS28215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRD51_RS28220	COG1611	Belongs to the LOG family
HRD51_RS28225	COG4221	oxidoreductase activity
HRD51_RS28235	COG0477	Major facilitator Superfamily
HRD51_RS28245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD51_RS28255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRD51_RS28260	COG0154	amidase activity
HRD51_RS28270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRD51_RS28280	COG0667	Aldo Keto reductase
HRD51_RS28305	COG2409	Drug exporters of the RND superfamily
HRD51_RS28320	COG1672	PFAM Archaeal ATPase
HRD51_RS28320	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRD51_RS28325	COG2133	pyrroloquinoline quinone binding
HRD51_RS28330	COG0667	Aldo Keto reductase
HRD51_RS28340	COG3300	MHYT domain
HRD51_RS28340	COG5001	Diguanylate cyclase
HRD51_RS28350	COG0440	acetolactate synthase activity
HRD51_RS28355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRD51_RS28360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD51_RS28380	COG3835	regulator
HRD51_RS28385	COG0506	proline dehydrogenase activity
HRD51_RS28390	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS28400	COG0473	3-isopropylmalate dehydrogenase activity
HRD51_RS28405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD51_RS28415	COG0832	Belongs to the urease beta subunit family
HRD51_RS28415	COG0831	urea catabolic process
HRD51_RS28420	COG0804	urea catabolic process
HRD51_RS28425	COG2957	Belongs to the agmatine deiminase family
HRD51_RS28430	COG1309	transcriptional regulator
HRD51_RS28435	COG0477	Major facilitator Superfamily
HRD51_RS28440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD51_RS28455	COG2353	YceI-like domain
HRD51_RS28460	COG5492	domain, Protein
HRD51_RS28465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRD51_RS28480	COG2376	Dihydroxyacetone kinase
HRD51_RS28495	COG2018	Roadblock/LC7 domain
HRD51_RS28515	COG2018	Roadblock/LC7 domain
HRD51_RS28530	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRD51_RS28535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD51_RS28570	COG1414	Transcriptional regulator
HRD51_RS28575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRD51_RS28580	COG0066	3-isopropylmalate dehydratase activity
HRD51_RS28590	COG0776	regulation of translation
HRD51_RS28600	COG1920	GTP binding
HRD51_RS28610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD51_RS28615	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRD51_RS28635	COG0351	phosphomethylpyrimidine kinase
HRD51_RS28640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRD51_RS28645	COG1461	Dihydroxyacetone kinase
HRD51_RS28655	COG0742	ribosomal rna small subunit methyltransferase
HRD51_RS28660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRD51_RS28675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRD51_RS28680	COG0571	ribonuclease III activity
HRD51_RS28685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRD51_RS28695	COG1254	Belongs to the acylphosphatase family
HRD51_RS28710	COG0477	Major facilitator Superfamily
HRD51_RS28725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HRD51_RS28760	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRD51_RS28780	COG0228	four-way junction DNA binding
HRD51_RS28785	COG1837	Belongs to the UPF0109 family
HRD51_RS28790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRD51_RS28795	COG0336	Belongs to the RNA methyltransferase TrmD family
HRD51_RS28800	COG0335	large ribosomal subunit rRNA binding
HRD51_RS28815	COG0681	Belongs to the peptidase S26 family
HRD51_RS28835	COG0792	nuclease activity
HRD51_RS28850	COG1191	sigma factor activity
HRD51_RS28865	COG0052	Belongs to the universal ribosomal protein uS2 family
HRD51_RS28870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRD51_RS28875	COG0528	UMP kinase activity
HRD51_RS28880	COG0233	cytoplasmic translational termination
HRD51_RS28890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRD51_RS28900	COG4208	sulfate ABC transporter
HRD51_RS28905	COG3842	ATPase activity
HRD51_RS28910	COG2197	response regulator
HRD51_RS28915	COG4585	Histidine kinase
HRD51_RS28925	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS28960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRD51_RS28970	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS28985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD51_RS28995	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS29005	COG3842	ATPase activity
HRD51_RS29010	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRD51_RS29015	COG1177	transmembrane transport
HRD51_RS29020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD51_RS29050	COG2508	Transcriptional regulator
HRD51_RS29055	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS29065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRD51_RS29065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRD51_RS29070	COG0750	zinc metalloprotease
HRD51_RS29075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRD51_RS29090	COG0442	prolyl-tRNA aminoacylation
HRD51_RS29095	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HRD51_RS29110	COG0779	Required for maturation of 30S ribosomal subunits
HRD51_RS29125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRD51_RS29135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRD51_RS29140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRD51_RS29155	COG0455	bacterial-type flagellum organization
HRD51_RS29185	COG1404	Belongs to the peptidase S8 family
HRD51_RS29205	COG1404	Belongs to the peptidase S8 family
HRD51_RS29315	COG1674	ftsk spoiiie
HRD51_RS29325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRD51_RS29330	COG1185	polyribonucleotide nucleotidyltransferase activity
HRD51_RS29335	COG0612	Peptidase, M16
HRD51_RS29340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRD51_RS29360	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HRD51_RS29365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD51_RS29370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HRD51_RS29405	COG3437	response regulator, receiver
HRD51_RS29405	COG2205	protein histidine kinase activity
HRD51_RS29405	COG4999	Histidine kinase
HRD51_RS29405	COG3850	Histidine kinase
HRD51_RS29415	COG1674	ftsk spoiiie
HRD51_RS29425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD51_RS29435	COG1546	Belongs to the CinA family
HRD51_RS29435	COG1058	Belongs to the CinA family
HRD51_RS29440	COG1396	sequence-specific DNA binding
HRD51_RS29445	COG0783	Belongs to the Dps family
HRD51_RS29455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRD51_RS29460	COG1201	RNA secondary structure unwinding
HRD51_RS29505	COG0640	Transcriptional regulator
HRD51_RS29510	COG1316	TRANSCRIPTIONal
HRD51_RS29525	COG0628	permease
HRD51_RS29540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD51_RS29555	COG0765	amino acid transport
HRD51_RS29560	COG4597	amino acid ABC transporter
HRD51_RS29570	COG1126	abc transporter atp-binding protein
HRD51_RS29580	COG2205	protein histidine kinase activity
HRD51_RS29600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD51_RS29615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRD51_RS29625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRD51_RS29630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD51_RS29640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRD51_RS29675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD51_RS29680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRD51_RS29685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD51_RS29710	COG0488	(ABC) transporter
HRD51_RS29715	COG0588	phosphoglycerate mutase activity
HRD51_RS29725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRD51_RS29740	COG0514	ATP-dependent DNA helicase (RecQ)
HRD51_RS29745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD51_RS29770	COG2197	response regulator
HRD51_RS29780	COG1136	(ABC) transporter
HRD51_RS29780	COG0577	efflux transmembrane transporter activity
HRD51_RS29825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD51_RS29840	COG0475	glutathione-regulated potassium exporter activity
HRD51_RS29850	COG1834	amidinotransferase
HRD51_RS29855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD51_RS29860	COG0134	indole-3-glycerol-phosphate synthase activity
HRD51_RS29865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD51_RS29875	COG0512	Glutamine amidotransferase of anthranilate synthase
HRD51_RS29875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD51_RS29885	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRD51_RS29900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRD51_RS29905	COG0066	3-isopropylmalate dehydratase activity
HRD51_RS29930	COG2186	Transcriptional regulator
HRD51_RS29935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRD51_RS29950	COG0187	DNA topoisomerase II activity
HRD51_RS29960	COG4585	Histidine kinase
HRD51_RS29965	COG2197	response regulator
HRD51_RS29980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRD51_RS29985	COG0612	Peptidase, M16
HRD51_RS29995	COG0739	heme binding
HRD51_RS30000	COG1802	Transcriptional regulator
HRD51_RS30005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD51_RS30030	COG1435	thymidine kinase activity
HRD51_RS30070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRD51_RS30075	COG0483	inositol monophosphate 1-phosphatase activity
HRD51_RS30085	COG0745	RESPONSE REGULATOR receiver
HRD51_RS30090	COG2205	protein histidine kinase activity
HRD51_RS30115	COG0756	dUTP diphosphatase activity
HRD51_RS30130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD51_RS30135	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD51_RS30140	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HRD51_RS30150	COG1136	(ABC) transporter
HRD51_RS30150	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD51_RS30185	COG0569	domain protein
HRD51_RS30195	COG0531	amino acid
HRD51_RS30200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD51_RS30225	COG3424	synthase
HRD51_RS30255	COG1309	transcriptional regulator
HRD51_RS30275	COG1799	cell septum assembly
HRD51_RS30305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD51_RS30310	COG4977	sequence-specific DNA binding
HRD51_RS30320	COG2235	arginine
HRD51_RS30325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRD51_RS30330	COG0531	amino acid
HRD51_RS30340	COG1024	Enoyl-CoA hydratase
HRD51_RS30360	COG0546	phosphoglycolate phosphatase activity
HRD51_RS30375	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS30390	COG2226	methyltransferase
HRD51_RS30395	COG2059	Chromate
HRD51_RS30405	COG2205	protein histidine kinase activity
HRD51_RS30415	COG0745	RESPONSE REGULATOR receiver
HRD51_RS30480	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HRD51_RS30620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRD51_RS30645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRD51_RS30660	COG1653	transport
HRD51_RS30665	COG1175	transmembrane transport
HRD51_RS30670	COG0395	ABC-type sugar transport system, permease component
HRD51_RS30675	COG1940	carbohydrate kinase activity
HRD51_RS30680	COG4213	ABC transporter substrate-binding protein
HRD51_RS30690	COG4214	carbohydrate transport
HRD51_RS30695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRD51_RS30700	COG0531	amino acid
HRD51_RS30710	COG1024	Enoyl-CoA hydratase
HRD51_RS30710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD51_RS30715	COG0183	Belongs to the thiolase family
HRD51_RS30720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRD51_RS30735	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRD51_RS30740	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRD51_RS30750	COG0183	Belongs to the thiolase family
HRD51_RS30760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HRD51_RS30765	COG3253	May function as heme-dependent peroxidase
HRD51_RS30810	COG1116	anion transmembrane transporter activity
HRD51_RS30845	COG1136	(ABC) transporter
HRD51_RS30845	COG0577	efflux transmembrane transporter activity
HRD51_RS30860	COG2197	response regulator
HRD51_RS30865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD51_RS30870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD51_RS30915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRD51_RS30945	COG0667	Aldo Keto reductase
HRD51_RS30990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HRD51_RS30995	COG0693	protein deglycase activity
HRD51_RS31010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD51_RS31015	COG0583	DNA-binding transcription factor activity
HRD51_RS31070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD51_RS31075	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HRD51_RS31095	COG0529	Catalyzes the synthesis of activated sulfate
HRD51_RS31100	COG0175	sulfate reduction
HRD51_RS31110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD51_RS31130	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS31140	COG1414	Transcriptional regulator
HRD51_RS31145	COG3485	protocatechuate 3,4-dioxygenase
HRD51_RS31150	COG3485	protocatechuate 3,4-dioxygenase
HRD51_RS31200	COG2080	2 iron, 2 sulfur cluster binding
HRD51_RS31205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HRD51_RS31210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRD51_RS31220	COG3511	phospholipase C
HRD51_RS31225	COG1376	ErfK ybiS ycfS ynhG family protein
HRD51_RS31250	COG1716	ATPase activity
HRD51_RS31250	COG0842	Transport permease protein
HRD51_RS31250	COG1131	(ABC) transporter
HRD51_RS31255	COG2233	PERMEase
HRD51_RS31305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS31305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS31310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD51_RS31325	COG0640	Transcriptional regulator
HRD51_RS31330	COG0745	RESPONSE REGULATOR receiver
HRD51_RS31340	COG1162	GTPase activity
HRD51_RS31355	COG0028	Belongs to the TPP enzyme family
HRD51_RS31380	COG1802	Transcriptional regulator
HRD51_RS31395	COG3835	regulator
HRD51_RS31410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRD51_RS31430	COG1733	regulation of RNA biosynthetic process
HRD51_RS31475	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS31490	COG2340	Cysteine-rich secretory protein family
HRD51_RS31500	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS31510	COG2315	Protein conserved in bacteria
HRD51_RS31525	COG0753	catalase activity
HRD51_RS31530	COG0028	Belongs to the TPP enzyme family
HRD51_RS31540	COG3622	Belongs to the hyi family
HRD51_RS31560	COG2351	hydroxyisourate hydrolase activity
HRD51_RS31570	COG2233	PERMEase
HRD51_RS31580	COG2233	PERMEase
HRD51_RS31605	COG1288	antiporter activity
HRD51_RS31620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRD51_RS31640	COG1414	Transcriptional regulator
HRD51_RS31650	COG1953	Uracil, thiamine, allantoin
HRD51_RS31655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRD51_RS31660	COG4266	Belongs to the allantoicase family
HRD51_RS31690	COG0800	Aldolase
HRD51_RS31705	COG2188	Transcriptional regulator
HRD51_RS31715	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD51_RS31725	COG1940	carbohydrate kinase activity
HRD51_RS31735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD51_RS31740	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HRD51_RS31755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD51_RS31760	COG0765	amino acid transport
HRD51_RS31765	COG0765	amino acid transport
HRD51_RS31790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD51_RS31795	COG2207	Transcriptional regulator
HRD51_RS31795	COG3708	Transcriptional regulator
HRD51_RS31800	COG0435	Glutathione S-transferase
HRD51_RS31810	COG2409	Drug exporters of the RND superfamily
HRD51_RS31815	COG0387	Pfam Sodium calcium exchanger
HRD51_RS31825	COG0405	Gamma-glutamyltransferase
HRD51_RS31835	COG1335	isochorismatase
HRD51_RS31840	COG0477	Major facilitator Superfamily
HRD51_RS31875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRD51_RS31890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRD51_RS31895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS31900	COG0095	Lipoate-protein ligase
HRD51_RS31910	COG4221	oxidoreductase activity
HRD51_RS31920	COG0483	inositol monophosphate 1-phosphatase activity
HRD51_RS31930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRD51_RS31960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRD51_RS31995	COG0667	Aldo Keto reductase
HRD51_RS32005	COG0494	nUDIX hydrolase
HRD51_RS32010	COG1929	Belongs to the glycerate kinase type-1 family
HRD51_RS32020	COG0688	phosphatidylethanolamine metabolic process
HRD51_RS32025	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS32035	COG2301	Belongs to the HpcH HpaI aldolase family
HRD51_RS32040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD51_RS32040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD51_RS32045	COG0604	alcohol dehydrogenase
HRD51_RS32060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD51_RS32110	COG0366	Alpha amylase catalytic
HRD51_RS32120	COG2362	D-Aminopeptidase
HRD51_RS32125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD51_RS32140	COG2124	cytochrome p450
HRD51_RS32155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRD51_RS32195	COG0251	oxidation-reduction process
HRD51_RS32210	COG1597	lipid kinase activity
HRD51_RS32245	COG0531	amino acid
HRD51_RS32260	COG2154	pterin-4-alpha-carbinolamine dehydratase
HRD51_RS32275	COG4106	trans-aconitate 2-methyltransferase activity
HRD51_RS32285	COG0656	L-ascorbic acid biosynthetic process
HRD51_RS32295	COG0583	DNA-binding transcription factor activity
HRD51_RS32310	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS32310	COG3321	synthase
HRD51_RS32310	COG0604	alcohol dehydrogenase
HRD51_RS32320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRD51_RS32330	COG1605	Chorismate mutase
HRD51_RS32330	COG0287	Prephenate dehydrogenase
HRD51_RS32350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRD51_RS32390	COG2801	Transposase and inactivated derivatives
HRD51_RS32410	COG2226	methyltransferase
HRD51_RS32435	COG2070	2-Nitropropane dioxygenase
HRD51_RS32435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRD51_RS32450	COG2409	Drug exporters of the RND superfamily
HRD51_RS32465	COG3209	COG3209 Rhs family protein
HRD51_RS32510	COG1484	DNA-dependent DNA replication
HRD51_RS32595	COG4977	sequence-specific DNA binding
HRD51_RS32615	COG1215	transferase activity, transferring glycosyl groups
HRD51_RS32675	COG1132	(ABC) transporter
HRD51_RS32710	COG1131	(ABC) transporter
HRD51_RS32725	COG2197	response regulator
HRD51_RS32780	COG0702	epimerase
HRD51_RS32785	COG1733	regulation of RNA biosynthetic process
HRD51_RS32805	COG1113	amino acid transport
HRD51_RS32825	COG0076	glutamate decarboxylase activity
HRD51_RS32830	COG2197	response regulator
HRD51_RS32870	COG1285	pathogenesis
HRD51_RS32875	COG0510	thiamine kinase activity
HRD51_RS32890	COG0789	Transcriptional regulator
HRD51_RS32945	COG1011	Hydrolase
HRD51_RS32980	COG2815	serine threonine protein kinase
HRD51_RS32980	COG0515	serine threonine protein kinase
HRD51_RS32985	COG0288	reversible hydration of carbon dioxide
HRD51_RS32990	COG0583	DNA-binding transcription factor activity
HRD51_RS32995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRD51_RS33020	COG1335	isochorismatase
HRD51_RS33080	COG1733	regulation of RNA biosynthetic process
HRD51_RS33095	COG1278	Cold shock
HRD51_RS33100	COG0513	Belongs to the DEAD box helicase family
HRD51_RS33110	COG1280	lysine exporter protein (LysE YggA)
HRD51_RS33145	COG0640	Transcriptional regulator
HRD51_RS33170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS33180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS33185	COG2409	Drug exporters of the RND superfamily
HRD51_RS33205	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS33245	COG0431	NADPH-dependent FMN reductase
HRD51_RS33255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS33260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD51_RS33275	COG2814	Major facilitator Superfamily
HRD51_RS33310	COG0583	DNA-binding transcription factor activity
HRD51_RS33320	COG2197	response regulator
HRD51_RS33340	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS33355	COG1113	amino acid transport
HRD51_RS33360	COG0137	argininosuccinate synthase activity
HRD51_RS33445	COG0789	Transcriptional regulator
HRD51_RS33450	COG0667	Aldo Keto reductase
HRD51_RS33475	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRD51_RS33480	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS33500	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD51_RS33515	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS33530	COG1136	(ABC) transporter
HRD51_RS33555	COG0583	DNA-binding transcription factor activity
HRD51_RS33600	COG2205	protein histidine kinase activity
HRD51_RS33605	COG0745	RESPONSE REGULATOR receiver
HRD51_RS33630	COG3226	Transcriptional regulator
HRD51_RS33640	COG1846	Transcriptional regulator
HRD51_RS33650	COG1309	transcriptional regulator
HRD51_RS33660	COG1309	transcriptional regulator
HRD51_RS33665	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS33670	COG1349	DNA-binding transcription factor activity
HRD51_RS33680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRD51_RS33685	COG2814	Major facilitator Superfamily
HRD51_RS33695	COG1515	deoxyribonuclease V activity
HRD51_RS33700	COG3268	Saccharopine dehydrogenase
HRD51_RS33710	COG1285	pathogenesis
HRD51_RS33720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRD51_RS33725	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS33730	COG0183	Belongs to the thiolase family
HRD51_RS33735	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD51_RS33735	COG1024	Enoyl-CoA hydratase
HRD51_RS33740	COG0789	Transcriptional regulator
HRD51_RS33750	COG1113	amino acid transport
HRD51_RS33770	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS33800	COG0308	aminopeptidase N
HRD51_RS33805	COG2936	dipeptidyl-peptidase activity
HRD51_RS33830	COG2183	response to ionizing radiation
HRD51_RS33875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD51_RS33910	COG1134	teichoic acid transport
HRD51_RS33915	COG1562	ergosterol biosynthetic process
HRD51_RS33925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HRD51_RS33935	COG1657	PFAM Prenyltransferase squalene oxidase
HRD51_RS33955	COG2365	Tyrosine phosphatase family
HRD51_RS33960	COG2755	lipolytic protein G-D-S-L family
HRD51_RS33985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD51_RS34005	COG2018	Roadblock/LC7 domain
HRD51_RS34025	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS34030	COG0402	S-adenosylhomocysteine deaminase activity
HRD51_RS34035	COG2267	carboxylic ester hydrolase activity
HRD51_RS34040	COG3958	Transketolase
HRD51_RS34045	COG3959	Transketolase, thiamine diphosphate binding domain
HRD51_RS34075	COG2124	cytochrome p450
HRD51_RS34080	COG1686	Belongs to the peptidase S11 family
HRD51_RS34115	COG3246	L-lysine catabolic process to acetate
HRD51_RS34130	COG0174	glutamine synthetase
HRD51_RS34140	COG0477	Major facilitator Superfamily
HRD51_RS34170	COG1024	Enoyl-CoA hydratase
HRD51_RS34175	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS34195	COG1113	amino acid transport
HRD51_RS34200	COG2706	6-phosphogluconolactonase activity
HRD51_RS34235	COG0149	triose-phosphate isomerase activity
HRD51_RS34245	COG0596	Alpha beta hydrolase
HRD51_RS34300	COG3537	Alpha-1,2-mannosidase
HRD51_RS34320	COG0531	amino acid
HRD51_RS34325	COG3360	Dodecin
HRD51_RS34340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRD51_RS34340	COG2124	cytochrome p450
HRD51_RS34365	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HRD51_RS34370	COG0121	glutamine amidotransferase
HRD51_RS34375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRD51_RS34380	COG3572	ergothioneine biosynthetic process
HRD51_RS34415	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS34420	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS34450	COG0601	transmembrane transport
HRD51_RS34455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD51_RS34460	COG0444	Belongs to the ABC transporter superfamily
HRD51_RS34480	COG2814	Major facilitator Superfamily
HRD51_RS34490	COG1070	Carbohydrate kinase
HRD51_RS34500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD51_RS34505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HRD51_RS34505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRD51_RS34530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS34530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS34535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS34540	COG1070	Carbohydrate kinase
HRD51_RS34545	COG3458	cephalosporin-C deacetylase activity
HRD51_RS34555	COG1126	abc transporter atp-binding protein
HRD51_RS34560	COG0765	amino acid transport
HRD51_RS34570	COG2040	homocysteine
HRD51_RS34585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRD51_RS34630	COG2018	Roadblock/LC7 domain
HRD51_RS34645	COG1946	Acyl-CoA thioesterase
HRD51_RS34660	COG1132	(ABC) transporter
HRD51_RS34665	COG1132	(ABC) transporter
HRD51_RS34675	COG1301	dicarboxylic acid transport
HRD51_RS34700	COG1132	(ABC) transporter
HRD51_RS34710	COG1556	Lactate utilization protein
HRD51_RS34715	COG1139	Iron-sulfur cluster binding protein
HRD51_RS34720	COG0247	lactate metabolic process
HRD51_RS34725	COG0477	Major facilitator Superfamily
HRD51_RS34735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD51_RS34740	COG0492	ferredoxin-NADP+ reductase activity
HRD51_RS34745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD51_RS34755	COG1116	anion transmembrane transporter activity
HRD51_RS34760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD51_RS34780	COG1802	Transcriptional regulator
HRD51_RS34790	COG3938	Belongs to the proline racemase family
HRD51_RS34810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD51_RS34895	COG0505	Belongs to the CarA family
HRD51_RS34900	COG2192	nodulation
HRD51_RS34925	COG0477	Major facilitator Superfamily
HRD51_RS34930	COG0667	Aldo Keto reductase
HRD51_RS34940	COG2271	Major facilitator Superfamily
HRD51_RS34945	COG2124	cytochrome p450
HRD51_RS34950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRD51_RS34955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD51_RS34960	COG0747	negative chemotaxis
HRD51_RS34970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD51_RS34975	COG4172	Belongs to the ABC transporter superfamily
HRD51_RS34985	COG0596	Alpha beta hydrolase
HRD51_RS34990	COG0154	amidase activity
HRD51_RS34995	COG0445	tRNA wobble uridine modification
HRD51_RS35000	COG0367	asparagine synthase
HRD51_RS35005	COG0367	asparagine synthase
HRD51_RS35015	COG2188	Transcriptional regulator
HRD51_RS35025	COG2304	oxidoreductase activity
HRD51_RS35030	COG3467	pyridoxamine 5'-phosphate
HRD51_RS35055	COG1309	transcriptional regulator
HRD51_RS35075	COG0789	Transcriptional regulator
HRD51_RS35090	COG1309	transcriptional regulator
HRD51_RS35125	COG4172	Belongs to the ABC transporter superfamily
HRD51_RS35130	COG4171	peptide transport system, permease
HRD51_RS35135	COG0601	transmembrane transport
HRD51_RS35140	COG4166	transmembrane transport
HRD51_RS35155	COG0019	diaminopimelate decarboxylase activity
HRD51_RS35160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRD51_RS35175	COG4213	ABC transporter substrate-binding protein
HRD51_RS35215	COG0831	urea catabolic process
HRD51_RS35215	COG0832	Belongs to the urease beta subunit family
HRD51_RS35220	COG0804	urea catabolic process
HRD51_RS35230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD51_RS35235	COG0829	nickel cation binding
HRD51_RS35240	COG2706	6-phosphogluconolactonase activity
HRD51_RS35255	COG2971	BadF BadG BcrA BcrD
HRD51_RS35265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRD51_RS35275	COG1902	pentaerythritol trinitrate reductase activity
HRD51_RS35285	COG3547	Transposase (IS116 IS110 IS902 family)
HRD51_RS35355	COG0740	serine-type endopeptidase activity
HRD51_RS35360	COG0740	serine-type endopeptidase activity
HRD51_RS35380	COG1309	transcriptional regulator
HRD51_RS35435	COG0583	DNA-binding transcription factor activity
HRD51_RS35445	COG1285	pathogenesis
HRD51_RS35470	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD51_RS35485	COG0477	Major facilitator Superfamily
HRD51_RS35490	COG1957	nucleoside hydrolase
HRD51_RS35495	COG1609	Transcriptional regulator
HRD51_RS35515	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HRD51_RS35535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HRD51_RS35535	COG1796	DNA polymerase
HRD51_RS35555	COG0657	acetylesterase activity
HRD51_RS35575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HRD51_RS35620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD51_RS35635	COG1902	pentaerythritol trinitrate reductase activity
HRD51_RS35650	COG2226	methyltransferase
HRD51_RS35705	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS35725	COG1309	transcriptional regulator
HRD51_RS35735	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS35760	COG1228	amidohydrolase
HRD51_RS35770	COG0463	Glycosyl transferase, family 2
HRD51_RS35815	COG3012	SEC-C Motif Domain Protein
HRD51_RS35825	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HRD51_RS35830	COG1793	dna ligase
HRD51_RS35830	COG3285	dna ligase
HRD51_RS35835	COG2814	Major facilitator Superfamily
HRD51_RS35845	COG1278	Cold shock
HRD51_RS35880	COG0395	ABC-type sugar transport system, permease component
HRD51_RS35885	COG1175	transmembrane transport
HRD51_RS35895	COG1609	Transcriptional regulator
HRD51_RS35910	COG4585	Histidine kinase
HRD51_RS35915	COG2197	response regulator
HRD51_RS35920	COG0739	heme binding
HRD51_RS35950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS35960	COG1846	Transcriptional regulator
HRD51_RS35965	COG1764	response to oxidative stress
HRD51_RS35970	COG2770	Histidine kinase
HRD51_RS35970	COG2208	phosphoserine phosphatase activity
HRD51_RS36020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD51_RS36090	COG2124	cytochrome p450
HRD51_RS36095	COG1024	Enoyl-CoA hydratase
HRD51_RS36105	COG0110	maltose O-acetyltransferase activity
HRD51_RS36125	COG1832	CoA-binding protein
HRD51_RS36135	COG1739	Uncharacterized protein family UPF0029
HRD51_RS36140	COG0531	amino acid
HRD51_RS36150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD51_RS36185	COG0420	3'-5' exonuclease activity
HRD51_RS36195	COG1522	sequence-specific DNA binding
HRD51_RS36220	COG0346	lactoylglutathione lyase activity
HRD51_RS36225	COG1595	DNA-templated transcription, initiation
HRD51_RS36230	COG2188	Transcriptional regulator
HRD51_RS36235	COG1940	carbohydrate kinase activity
HRD51_RS36250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD51_RS36275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRD51_RS36365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRD51_RS36370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRD51_RS36375	COG0156	8-amino-7-oxononanoate synthase activity
HRD51_RS36385	COG0791	NLP P60 protein
HRD51_RS36395	COG0740	serine-type endopeptidase activity
HRD51_RS36410	COG0831	urea catabolic process
HRD51_RS36420	COG0804	urea catabolic process
HRD51_RS36430	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD51_RS36435	COG0829	nickel cation binding
HRD51_RS36465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRD51_RS36490	COG3336	cytochrome c oxidase
HRD51_RS36495	COG0205	6-phosphofructokinase activity
HRD51_RS36500	COG3442	glutamine amidotransferase
HRD51_RS36510	COG0242	peptide deformylase activity
HRD51_RS36520	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS36585	COG2814	Major facilitator Superfamily
HRD51_RS36605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD51_RS36640	COG3960	tartronate-semialdehyde synthase activity
HRD51_RS36645	COG3622	Belongs to the hyi family
HRD51_RS36650	COG2084	Dehydrogenase
HRD51_RS36655	COG2124	cytochrome p450
HRD51_RS36670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD51_RS36675	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS36695	COG2186	Transcriptional regulator
HRD51_RS36700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD51_RS36715	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HRD51_RS36745	COG0375	protein maturation
HRD51_RS36750	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD51_RS36760	COG0298	carbon dioxide binding
HRD51_RS36770	COG0309	Hydrogenase expression formation protein (HypE)
HRD51_RS36790	COG2837	iron assimilation
HRD51_RS36810	COG0640	Transcriptional regulator
HRD51_RS36815	COG0531	amino acid
HRD51_RS36830	COG1793	dna ligase
HRD51_RS36845	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS36895	COG2233	PERMEase
HRD51_RS36920	COG0657	acetylesterase activity
HRD51_RS36950	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS36955	COG1960	acyl-CoA dehydrogenase activity
HRD51_RS36960	COG1024	Enoyl-CoA hydratase
HRD51_RS36975	COG1309	transcriptional regulator
HRD51_RS36980	COG0183	Belongs to the thiolase family
HRD51_RS37005	COG2365	Tyrosine phosphatase family
HRD51_RS37035	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS37065	COG3511	phospholipase C
HRD51_RS37125	COG2261	transglycosylase associated protein
HRD51_RS37145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD51_RS37150	COG1316	TRANSCRIPTIONal
HRD51_RS37165	COG0640	Transcriptional regulator
HRD51_RS37205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRD51_RS37210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD51_RS37230	COG2837	iron assimilation
HRD51_RS37255	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
HRD51_RS37265	COG2268	Band 7 protein
HRD51_RS37270	COG1585	Membrane protein implicated in regulation of membrane protease activity
HRD51_RS37330	COG3848	Pyruvate phosphate dikinase
HRD51_RS37330	COG0574	Belongs to the PEP-utilizing enzyme family
HRD51_RS37360	COG0583	DNA-binding transcription factor activity
HRD51_RS37370	COG0477	Major facilitator Superfamily
HRD51_RS37395	COG4977	sequence-specific DNA binding
HRD51_RS37420	COG0531	amino acid
HRD51_RS37440	COG1116	anion transmembrane transporter activity
HRD51_RS37505	COG0789	Transcriptional regulator
HRD51_RS37510	COG0583	DNA-binding transcription factor activity
HRD51_RS37520	COG0667	Aldo Keto reductase
HRD51_RS37565	COG2197	response regulator
HRD51_RS37570	COG4585	Histidine kinase
HRD51_RS37580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRD51_RS37585	COG0443	Heat shock 70 kDa protein
HRD51_RS37615	COG1017	nitric oxide dioxygenase activity
HRD51_RS37615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD51_RS37620	COG0745	RESPONSE REGULATOR receiver
HRD51_RS37625	COG2205	protein histidine kinase activity
HRD51_RS37635	COG1733	regulation of RNA biosynthetic process
HRD51_RS37645	COG2239	Acts as a magnesium transporter
HRD51_RS37675	COG0640	Transcriptional regulator
HRD51_RS37680	COG0301	tRNA thio-modification
HRD51_RS37685	COG1216	Glycosyl transferase, family 2
HRD51_RS37690	COG0488	(ABC) transporter
HRD51_RS37695	COG2226	methyltransferase
HRD51_RS37710	COG0367	asparagine synthase
HRD51_RS37720	COG2423	ornithine cyclodeaminase activity
HRD51_RS37725	COG3469	chitinase activity
HRD51_RS37730	COG0009	L-threonylcarbamoyladenylate synthase
HRD51_RS37750	COG2378	regulation of single-species biofilm formation
HRD51_RS37770	COG3631	Ketosteroid isomerase-related protein
HRD51_RS37780	COG1191	sigma factor activity
HRD51_RS37805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD51_RS37825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD51_RS37835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS37840	COG2132	Multicopper oxidase
HRD51_RS37855	COG2226	methyltransferase
HRD51_RS37880	COG1175	transmembrane transport
HRD51_RS37885	COG0395	ABC-type sugar transport system, permease component
HRD51_RS37905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRD51_RS38000	COG2205	protein histidine kinase activity
HRD51_RS38180	COG1309	transcriptional regulator
HRD51_RS38200	COG3757	hydrolase, family 25
HRD51_RS38200	COG3409	Peptidoglycan-binding domain 1 protein
HRD51_RS38230	COG0657	acetylesterase activity
HRD51_RS38235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD51_RS38265	COG1464	Belongs to the NlpA lipoprotein family
HRD51_RS38275	COG2011	ABC-type metal ion transport system permease component
HRD51_RS38310	COG0504	CTP synthase activity
HRD51_RS38335	COG0789	Transcriptional regulator
HRD51_RS38340	COG3118	belongs to the thioredoxin family
HRD51_RS38340	COG0492	ferredoxin-NADP+ reductase activity
HRD51_RS38360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRD51_RS38425	COG0604	alcohol dehydrogenase
HRD51_RS38425	COG3321	synthase
HRD51_RS38450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD51_RS38480	COG0604	alcohol dehydrogenase
HRD51_RS38480	COG3321	synthase
HRD51_RS38525	COG1473	amidohydrolase
HRD51_RS38540	COG0242	peptide deformylase activity
HRD51_RS38560	COG4221	oxidoreductase activity
HRD51_RS38570	COG2197	response regulator
HRD51_RS38575	COG3851	Histidine kinase
HRD51_RS38670	COG1484	DNA-dependent DNA replication
HRD51_RS38685	COG2130	NADP-dependent
HRD51_RS38695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRD51_RS38715	COG2226	methyltransferase
HRD51_RS38750	COG1595	DNA-templated transcription, initiation
HRD51_RS38850	COG1231	oxidoreductase activity
HRD51_RS38940	COG0393	Putative heavy-metal-binding
HRD51_RS38950	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS38965	COG2755	lipolytic protein G-D-S-L family
HRD51_RS38980	COG0577	efflux transmembrane transporter activity
HRD51_RS38980	COG1136	(ABC) transporter
HRD51_RS38990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HRD51_RS39020	COG0477	Major facilitator Superfamily
HRD51_RS39055	COG4941	Belongs to the sigma-70 factor family
HRD51_RS39105	COG0587	DNA-directed DNA polymerase activity
HRD51_RS39120	COG0539	negative regulation of cytoplasmic translation
HRD51_RS39135	COG1136	(ABC) transporter
HRD51_RS39140	COG0577	efflux transmembrane transporter activity
HRD51_RS39145	COG0745	RESPONSE REGULATOR receiver
HRD51_RS39150	COG2205	protein histidine kinase activity
HRD51_RS39155	COG2226	methyltransferase
HRD51_RS39160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HRD51_RS39185	COG0477	Major facilitator Superfamily
HRD51_RS39195	COG2226	methyltransferase
HRD51_RS39200	COG1846	Transcriptional regulator
HRD51_RS39205	COG3961	Belongs to the TPP enzyme family
HRD51_RS39225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD51_RS39235	COG0515	serine threonine protein kinase
HRD51_RS39235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD51_RS39260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRD51_RS39280	COG0243	molybdopterin cofactor binding
HRD51_RS39315	COG0142	geranyltranstransferase activity
HRD51_RS39330	COG1131	(ABC) transporter
HRD51_RS39365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD51_RS39370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD51_RS39385	COG1611	Belongs to the LOG family
HRD51_RS39390	COG0463	Glycosyl transferase, family 2
HRD51_RS39405	COG2070	2-Nitropropane dioxygenase
HRD51_RS39410	COG2226	methyltransferase
HRD51_RS39465	COG4585	Histidine kinase
HRD51_RS39500	COG2409	Drug exporters of the RND superfamily
HRD51_RS39595	COG0202	RNA polymerase activity
HRD51_RS39635	COG4221	oxidoreductase activity
HRD51_RS39640	COG2197	response regulator
HRD51_RS39655	COG2814	Major facilitator Superfamily
HRD51_RS39665	COG1333	cytochrome c biogenesis protein
HRD51_RS39715	COG0667	Aldo Keto reductase
HRD51_RS39725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS39730	COG0667	Aldo Keto reductase
HRD51_RS39750	COG0477	Major facilitator Superfamily
HRD51_RS39770	COG0156	8-amino-7-oxononanoate synthase activity
HRD51_RS39775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS39780	COG2409	Drug exporters of the RND superfamily
HRD51_RS39785	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HRD51_RS39810	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS39835	COG0038	chloride channel
HRD51_RS39840	COG0640	Transcriptional regulator
HRD51_RS39845	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD51_RS39905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS39915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS39945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRD51_RS39950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRD51_RS39960	COG4221	oxidoreductase activity
HRD51_RS39975	COG0596	Alpha beta hydrolase
HRD51_RS39990	COG2267	carboxylic ester hydrolase activity
HRD51_RS40010	COG3328	transposase activity
HRD51_RS40015	COG1902	pentaerythritol trinitrate reductase activity
HRD51_RS40020	COG1846	Transcriptional regulator
HRD51_RS40025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRD51_RS40040	COG1316	TRANSCRIPTIONal
HRD51_RS40045	COG1215	transferase activity, transferring glycosyl groups
HRD51_RS40070	COG3291	Pkd domain containing protein
HRD51_RS40075	COG0583	DNA-binding transcription factor activity
HRD51_RS40110	COG0483	inositol monophosphate 1-phosphatase activity
HRD51_RS40130	COG0730	response to heat
HRD51_RS40135	COG1937	Protein conserved in bacteria
HRD51_RS40155	COG0444	Belongs to the ABC transporter superfamily
HRD51_RS40170	COG2957	Belongs to the agmatine deiminase family
HRD51_RS40190	COG1132	(ABC) transporter
HRD51_RS40195	COG1309	transcriptional regulator
HRD51_RS40215	COG1136	(ABC) transporter
HRD51_RS40225	COG4585	Histidine kinase
HRD51_RS40230	COG2197	response regulator
HRD51_RS40250	COG4257	antibiotic catabolic process
HRD51_RS40275	COG1309	transcriptional regulator
HRD51_RS40285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD51_RS40295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD51_RS40310	COG2814	Major facilitator Superfamily
HRD51_RS40320	COG0583	DNA-binding transcription factor activity
HRD51_RS40345	COG2326	polyphosphate kinase activity
HRD51_RS40355	COG0517	IMP dehydrogenase activity
HRD51_RS40355	COG0516	GMP reductase activity
HRD51_RS40455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRD51_RS40470	COG0488	(ABC) transporter
HRD51_RS40485	COG1595	DNA-templated transcription, initiation
HRD51_RS40495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRD51_RS40510	COG1309	transcriptional regulator
HRD51_RS40585	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS40610	COG2197	response regulator
HRD51_RS40625	COG1683	Conserved Protein
HRD51_RS40640	COG2205	protein histidine kinase activity
HRD51_RS40650	COG3795	YCII-related domain
HRD51_RS40655	COG4941	Belongs to the sigma-70 factor family
HRD51_RS40670	COG4221	oxidoreductase activity
HRD51_RS40710	COG1454	alcohol dehydrogenase
HRD51_RS40715	COG1012	belongs to the aldehyde dehydrogenase family
HRD51_RS40720	COG2197	response regulator
HRD51_RS40730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD51_RS40745	COG4585	Histidine kinase
HRD51_RS40755	COG2814	Major facilitator Superfamily
HRD51_RS40775	COG1335	isochorismatase
HRD51_RS40790	COG3979	chitinase
HRD51_RS40820	COG2124	cytochrome p450
HRD51_RS40890	COG0604	alcohol dehydrogenase
HRD51_RS40890	COG3321	synthase
HRD51_RS40905	COG1309	transcriptional regulator
HRD51_RS40910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD51_RS40930	COG0318	PFAM AMP-dependent synthetase and ligase
HRD51_RS40935	COG0010	Belongs to the arginase family
HRD51_RS40945	COG0515	serine threonine protein kinase
HRD51_RS40955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS40965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD51_RS40975	COG0028	Belongs to the TPP enzyme family
HRD51_RS41005	COG1028	Short-chain dehydrogenase reductase Sdr
HRD51_RS41015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD51_RS41065	COG2208	phosphoserine phosphatase activity
HRD51_RS41065	COG2770	Histidine kinase
HRD51_RS41135	COG0583	DNA-binding transcription factor activity
HRD51_RS41170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HRD51_RS41225	COG3328	transposase activity
HRD51_RS41240	COG0477	Major facilitator Superfamily
HRD51_RS41320	COG4584	PFAM Integrase catalytic
HRD51_RS41325	COG1484	DNA-dependent DNA replication
HRD51_RS41340	COG1309	transcriptional regulator
HRD51_RS41370	COG0009	L-threonylcarbamoyladenylate synthase
HRD51_RS41375	COG4974	Belongs to the 'phage' integrase family
HRD51_RS41385	COG0667	Aldo Keto reductase
HRD51_RS41390	COG1309	transcriptional regulator
HRD51_RS41435	COG0431	NADPH-dependent FMN reductase
HRD51_RS41505	COG3328	transposase activity
HRD51_RS41555	COG4585	Histidine kinase
HRD51_RS41665	COG2197	response regulator
HRD51_RS41675	COG0556	nucleotide-excision repair
HRD51_RS41805	COG0438	transferase activity, transferring glycosyl groups
HRD51_RS41855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD51_RS41865	COG3209	COG3209 Rhs family protein
HRD51_RS41900	COG0671	phosphoesterase, PA-phosphatase related
HRD51_RS41990	COG2197	response regulator