locus-tag	class	description
K5X85_RS00030	COG0300	oxidoreductase activity
K5X85_RS00060	COG0515	serine threonine protein kinase
K5X85_RS00060	COG2815	serine threonine protein kinase
K5X85_RS00085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5X85_RS00120	COG3629	intracellular signal transduction
K5X85_RS00120	COG3903	Transcriptional regulator
K5X85_RS00125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5X85_RS00165	COG0745	RESPONSE REGULATOR receiver
K5X85_RS00175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5X85_RS00185	COG0154	amidase activity
K5X85_RS00255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS00275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS00330	COG2867	negative regulation of translational initiation
K5X85_RS00340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS00345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS00375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5X85_RS00390	COG0702	epimerase
K5X85_RS00540	COG1518	maintenance of DNA repeat elements
K5X85_RS00545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5X85_RS00565	COG0477	Major facilitator Superfamily
K5X85_RS00585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5X85_RS00675	COG3033	Beta-eliminating lyase
K5X85_RS00695	COG2207	Transcriptional regulator
K5X85_RS00710	COG2272	Belongs to the type-B carboxylesterase lipase family
K5X85_RS00720	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K5X85_RS00720	COG1672	PFAM Archaeal ATPase
K5X85_RS00745	COG3046	protein related to deoxyribodipyrimidine photolyase
K5X85_RS00750	COG0142	geranyltranstransferase activity
K5X85_RS00770	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
K5X85_RS00775	COG2226	methyltransferase
K5X85_RS00785	COG0300	oxidoreductase activity
K5X85_RS00835	COG0517	IMP dehydrogenase activity
K5X85_RS00835	COG0516	GMP reductase activity
K5X85_RS00840	COG1063	alcohol dehydrogenase
K5X85_RS00880	COG0589	response to stress
K5X85_RS00935	COG2197	response regulator
K5X85_RS00940	COG4585	Histidine kinase
K5X85_RS00970	COG0149	triose-phosphate isomerase activity
K5X85_RS01035	COG0517	IMP dehydrogenase activity
K5X85_RS01045	COG1063	alcohol dehydrogenase
K5X85_RS01065	COG0517	IMP dehydrogenase activity
K5X85_RS01070	COG1042	CoA-binding domain protein
K5X85_RS01070	COG0045	succinate-CoA ligase (ADP-forming) activity
K5X85_RS01070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5X85_RS01110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5X85_RS01120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5X85_RS01135	COG0574	Belongs to the PEP-utilizing enzyme family
K5X85_RS01135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5X85_RS01145	COG0516	GMP reductase activity
K5X85_RS01145	COG0517	IMP dehydrogenase activity
K5X85_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS01150	COG1454	alcohol dehydrogenase
K5X85_RS01160	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
K5X85_RS01175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5X85_RS01175	COG4651	solute:proton antiporter activity
K5X85_RS01180	COG0490	domain, Protein
K5X85_RS01180	COG2985	domain, Protein
K5X85_RS01220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K5X85_RS01245	COG0655	NAD(P)H dehydrogenase (quinone) activity
K5X85_RS01270	COG2226	methyltransferase
K5X85_RS01290	COG3483	tryptophan 2,3-dioxygenase activity
K5X85_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS01300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5X85_RS01305	COG2151	metal-sulfur cluster biosynthetic enzyme
K5X85_RS01310	COG3396	Phenylacetate-CoA oxygenase
K5X85_RS01320	COG3396	Phenylacetate-CoA oxygenase
K5X85_RS01345	COG0604	alcohol dehydrogenase
K5X85_RS01355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K5X85_RS01360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K5X85_RS01365	COG1595	DNA-templated transcription, initiation
K5X85_RS01415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5X85_RS01425	COG3959	Transketolase, thiamine diphosphate binding domain
K5X85_RS01440	COG3321	synthase
K5X85_RS01440	COG0604	alcohol dehydrogenase
K5X85_RS01455	COG0604	alcohol dehydrogenase
K5X85_RS01455	COG3321	synthase
K5X85_RS01470	COG3321	synthase
K5X85_RS01470	COG0604	alcohol dehydrogenase
K5X85_RS01520	COG2124	cytochrome p450
K5X85_RS01530	COG0142	geranyltranstransferase activity
K5X85_RS01550	COG2770	Histidine kinase
K5X85_RS01550	COG2208	phosphoserine phosphatase activity
K5X85_RS01555	COG0596	Alpha beta hydrolase
K5X85_RS01560	COG3321	synthase
K5X85_RS01560	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS01560	COG0604	alcohol dehydrogenase
K5X85_RS01600	COG2267	carboxylic ester hydrolase activity
K5X85_RS01610	COG1309	transcriptional regulator
K5X85_RS01625	COG3631	Ketosteroid isomerase-related protein
K5X85_RS01630	COG0702	epimerase
K5X85_RS01635	COG2409	Drug exporters of the RND superfamily
K5X85_RS01640	COG4585	Histidine kinase
K5X85_RS01645	COG2197	response regulator
K5X85_RS01655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS01680	COG2353	YceI-like domain
K5X85_RS01685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K5X85_RS01690	COG2318	DinB family
K5X85_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS01725	COG1131	(ABC) transporter
K5X85_RS01770	COG0494	nUDIX hydrolase
K5X85_RS01785	COG0702	epimerase
K5X85_RS01805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5X85_RS01820	COG0789	Transcriptional regulator
K5X85_RS01835	COG1522	sequence-specific DNA binding
K5X85_RS01845	COG0477	Major facilitator Superfamily
K5X85_RS01855	COG1231	oxidoreductase activity
K5X85_RS01860	COG2132	Multicopper oxidase
K5X85_RS01875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5X85_RS01920	COG1289	transmembrane transporter activity
K5X85_RS01925	COG0583	DNA-binding transcription factor activity
K5X85_RS01940	COG0542	response to heat
K5X85_RS01955	COG1175	transmembrane transport
K5X85_RS01960	COG0395	ABC-type sugar transport system, permease component
K5X85_RS01970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X85_RS01975	COG0800	Aldolase
K5X85_RS01980	COG4948	Mandelate Racemase Muconate Lactonizing
K5X85_RS01990	COG2186	Transcriptional regulator
K5X85_RS02010	COG2188	Transcriptional regulator
K5X85_RS02040	COG0745	RESPONSE REGULATOR receiver
K5X85_RS02060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5X85_RS02060	COG1116	anion transmembrane transporter activity
K5X85_RS02065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5X85_RS02075	COG0431	NADPH-dependent FMN reductase
K5X85_RS02080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS02085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS02090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS02095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5X85_RS02105	COG1126	abc transporter atp-binding protein
K5X85_RS02110	COG0765	amino acid transport
K5X85_RS02125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS02130	COG0765	amino acid transport
K5X85_RS02140	COG3507	Belongs to the glycosyl hydrolase 43 family
K5X85_RS02150	COG0488	(ABC) transporter
K5X85_RS02155	COG0798	PFAM Bile acid sodium symporter
K5X85_RS02160	COG0640	Transcriptional regulator
K5X85_RS02165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5X85_RS02200	COG2226	methyltransferase
K5X85_RS02215	COG1619	proteins homologs of microcin C7 resistance protein MccF
K5X85_RS02230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5X85_RS02250	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5X85_RS02260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5X85_RS02265	COG1120	ATPase activity
K5X85_RS02285	COG0531	amino acid
K5X85_RS02330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS02345	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5X85_RS02380	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS02385	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS02390	COG2172	sigma factor antagonist activity
K5X85_RS02405	COG0667	Aldo Keto reductase
K5X85_RS02410	COG1733	regulation of RNA biosynthetic process
K5X85_RS02430	COG0477	Major facilitator Superfamily
K5X85_RS02440	COG4191	Histidine kinase
K5X85_RS02445	COG0572	uridine kinase
K5X85_RS02465	COG2072	flavoprotein involved in K transport
K5X85_RS02490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS02495	COG1120	ATPase activity
K5X85_RS02505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5X85_RS02510	COG0583	DNA-binding transcription factor activity
K5X85_RS02515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS02525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5X85_RS02540	COG4709	membrane
K5X85_RS02560	COG2814	Major facilitator Superfamily
K5X85_RS02570	COG1609	Transcriptional regulator
K5X85_RS02575	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K5X85_RS02580	COG0659	secondary active sulfate transmembrane transporter activity
K5X85_RS02585	COG0789	Transcriptional regulator
K5X85_RS02665	COG1309	transcriptional regulator
K5X85_RS02720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5X85_RS02720	COG2755	lipolytic protein G-D-S-L family
K5X85_RS02730	COG0666	response to abiotic stimulus
K5X85_RS02735	COG2208	phosphoserine phosphatase activity
K5X85_RS02775	COG0714	Associated with various cellular activities
K5X85_RS02785	COG1733	regulation of RNA biosynthetic process
K5X85_RS02830	COG4941	Belongs to the sigma-70 factor family
K5X85_RS02835	COG3795	YCII-related domain
K5X85_RS02850	COG1733	regulation of RNA biosynthetic process
K5X85_RS02855	COG5640	endopeptidase activity
K5X85_RS02870	COG2353	YceI-like domain
K5X85_RS02905	COG0154	amidase activity
K5X85_RS02910	COG1309	transcriptional regulator
K5X85_RS02990	COG0395	ABC-type sugar transport system, permease component
K5X85_RS03030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5X85_RS03035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5X85_RS03055	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K5X85_RS03070	COG2239	Acts as a magnesium transporter
K5X85_RS03080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K5X85_RS03085	COG2409	Drug exporters of the RND superfamily
K5X85_RS03125	COG3226	Transcriptional regulator
K5X85_RS03130	COG2391	methyltransferase activity
K5X85_RS03135	COG0326	Molecular chaperone. Has ATPase activity
K5X85_RS03150	COG2755	lipolytic protein G-D-S-L family
K5X85_RS03155	COG4977	sequence-specific DNA binding
K5X85_RS03200	COG2175	clavaminate synthase activity
K5X85_RS03210	COG0395	ABC-type sugar transport system, permease component
K5X85_RS03215	COG1175	transmembrane transport
K5X85_RS03235	COG1953	Uracil, thiamine, allantoin
K5X85_RS03260	COG3795	YCII-related domain
K5X85_RS03265	COG4941	Belongs to the sigma-70 factor family
K5X85_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS03305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5X85_RS03310	COG2151	metal-sulfur cluster biosynthetic enzyme
K5X85_RS03315	COG3396	Phenylacetate-CoA oxygenase
K5X85_RS03320	COG3460	Phenylacetate-CoA oxygenase
K5X85_RS03325	COG3396	Phenylacetate-CoA oxygenase
K5X85_RS03330	COG2050	protein possibly involved in aromatic compounds catabolism
K5X85_RS03380	COG5640	endopeptidase activity
K5X85_RS03385	COG1119	ATPase activity
K5X85_RS03400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5X85_RS03410	COG1335	isochorismatase
K5X85_RS03465	COG0583	DNA-binding transcription factor activity
K5X85_RS03470	COG2124	cytochrome p450
K5X85_RS03490	COG3340	Belongs to the peptidase S51 family
K5X85_RS03500	COG0583	DNA-binding transcription factor activity
K5X85_RS03515	COG2814	Major facilitator Superfamily
K5X85_RS03525	COG0583	DNA-binding transcription factor activity
K5X85_RS03530	COG5640	endopeptidase activity
K5X85_RS03550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5X85_RS03550	COG1017	nitric oxide dioxygenase activity
K5X85_RS03555	COG1959	2 iron, 2 sulfur cluster binding
K5X85_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS03615	COG0028	Belongs to the TPP enzyme family
K5X85_RS03625	COG4209	transmembrane transport
K5X85_RS03630	COG0395	ABC-type sugar transport system, permease component
K5X85_RS03650	COG0110	maltose O-acetyltransferase activity
K5X85_RS03670	COG1120	ATPase activity
K5X85_RS03745	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
K5X85_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS03775	COG0475	glutathione-regulated potassium exporter activity
K5X85_RS03805	COG0142	geranyltranstransferase activity
K5X85_RS03815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K5X85_RS03820	COG2124	cytochrome p450
K5X85_RS03825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5X85_RS03865	COG0456	acetyltransferase
K5X85_RS03870	COG0243	molybdopterin cofactor binding
K5X85_RS03925	COG0753	catalase activity
K5X85_RS03955	COG0009	L-threonylcarbamoyladenylate synthase
K5X85_RS04000	COG1793	dna ligase
K5X85_RS04000	COG3285	dna ligase
K5X85_RS04010	COG0181	hydroxymethylbilane synthase activity
K5X85_RS04020	COG1191	sigma factor activity
K5X85_RS04050	COG0366	Alpha amylase catalytic
K5X85_RS04065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K5X85_RS04070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K5X85_RS04100	COG5002	protein histidine kinase activity
K5X85_RS04100	COG2205	protein histidine kinase activity
K5X85_RS04100	COG0784	Response regulator, receiver
K5X85_RS04115	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS04120	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS04125	COG2172	sigma factor antagonist activity
K5X85_RS04235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5X85_RS04265	COG2197	response regulator
K5X85_RS04270	COG2340	Cysteine-rich secretory protein family
K5X85_RS04280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K5X85_RS04285	COG0515	serine threonine protein kinase
K5X85_RS04285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5X85_RS04290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS04310	COG0667	Aldo Keto reductase
K5X85_RS04320	COG0328	RNA-DNA hybrid ribonuclease activity
K5X85_RS04335	COG0740	serine-type endopeptidase activity
K5X85_RS04340	COG0740	serine-type endopeptidase activity
K5X85_RS04345	COG1396	sequence-specific DNA binding
K5X85_RS04350	COG1191	sigma factor activity
K5X85_RS04380	COG0667	Aldo Keto reductase
K5X85_RS04385	COG0583	DNA-binding transcription factor activity
K5X85_RS04395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5X85_RS04400	COG0346	lactoylglutathione lyase activity
K5X85_RS04410	COG0667	Aldo Keto reductase
K5X85_RS04420	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS04470	COG0673	inositol 2-dehydrogenase activity
K5X85_RS04510	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS04515	COG2366	antibiotic biosynthetic process
K5X85_RS04520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5X85_RS04535	COG0515	serine threonine protein kinase
K5X85_RS04565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K5X85_RS04575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K5X85_RS04580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K5X85_RS04595	COG2205	protein histidine kinase activity
K5X85_RS04600	COG0745	RESPONSE REGULATOR receiver
K5X85_RS04630	COG0154	amidase activity
K5X85_RS04640	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K5X85_RS04645	COG0515	serine threonine protein kinase
K5X85_RS04645	COG2815	serine threonine protein kinase
K5X85_RS04655	COG1228	amidohydrolase
K5X85_RS04660	COG1959	2 iron, 2 sulfur cluster binding
K5X85_RS04665	COG2326	polyphosphate kinase activity
K5X85_RS04670	COG1733	regulation of RNA biosynthetic process
K5X85_RS04700	COG0246	Mannitol dehydrogenase
K5X85_RS04705	COG0477	Major facilitator Superfamily
K5X85_RS04710	COG1063	alcohol dehydrogenase
K5X85_RS04775	COG1132	(ABC) transporter
K5X85_RS04780	COG1132	(ABC) transporter
K5X85_RS04805	COG1509	lysine 2,3-aminomutase activity
K5X85_RS04830	COG0673	inositol 2-dehydrogenase activity
K5X85_RS04835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K5X85_RS04840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5X85_RS04860	COG3173	Aminoglycoside phosphotransferase
K5X85_RS04900	COG2376	Dihydroxyacetone kinase
K5X85_RS04905	COG1461	Dihydroxyacetone kinase
K5X85_RS04910	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K5X85_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS04945	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5X85_RS04945	COG1902	pentaerythritol trinitrate reductase activity
K5X85_RS04965	COG2890	protein-(glutamine-N5) methyltransferase activity
K5X85_RS04980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K5X85_RS04995	COG3458	cephalosporin-C deacetylase activity
K5X85_RS05000	COG2188	Transcriptional regulator
K5X85_RS05010	COG1695	Transcriptional regulator
K5X85_RS05020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5X85_RS05025	COG1686	Belongs to the peptidase S11 family
K5X85_RS05030	COG2066	Belongs to the glutaminase family
K5X85_RS05040	COG1968	undecaprenyl-diphosphatase activity
K5X85_RS05060	COG1175	transmembrane transport
K5X85_RS05065	COG0395	ABC-type sugar transport system, permease component
K5X85_RS05075	COG1846	Transcriptional regulator
K5X85_RS05100	COG0137	argininosuccinate synthase activity
K5X85_RS05125	COG1175	transmembrane transport
K5X85_RS05130	COG1653	transport
K5X85_RS05135	COG1609	Transcriptional regulator
K5X85_RS05160	COG1309	transcriptional regulator
K5X85_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS05195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K5X85_RS05200	COG0463	Glycosyl transferase, family 2
K5X85_RS05235	COG1349	DNA-binding transcription factor activity
K5X85_RS05285	COG1940	carbohydrate kinase activity
K5X85_RS05295	COG2813	Specifically methylates the guanine in position
K5X85_RS05305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5X85_RS05350	COG0783	Belongs to the Dps family
K5X85_RS05365	COG1501	Belongs to the glycosyl hydrolase 31 family
K5X85_RS05375	COG1175	transmembrane transport
K5X85_RS05380	COG0395	ABC-type sugar transport system, permease component
K5X85_RS05385	COG2723	6-phospho-beta-galactosidase activity
K5X85_RS05415	COG2197	response regulator
K5X85_RS05420	COG4585	Histidine kinase
K5X85_RS05425	COG0445	tRNA wobble uridine modification
K5X85_RS05440	COG1660	Displays ATPase and GTPase activities
K5X85_RS05490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K5X85_RS05510	COG0204	Acyl-transferase
K5X85_RS05535	COG0584	glycerophosphoryl diester phosphodiesterase
K5X85_RS05575	COG0671	phosphoesterase, PA-phosphatase related
K5X85_RS05600	COG0640	Transcriptional regulator
K5X85_RS05605	COG1902	pentaerythritol trinitrate reductase activity
K5X85_RS05620	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS05630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K5X85_RS05645	COG2706	6-phosphogluconolactonase activity
K5X85_RS05660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X85_RS05695	COG4221	oxidoreductase activity
K5X85_RS05705	COG0726	polysaccharide deacetylase
K5X85_RS05715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K5X85_RS05720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K5X85_RS05725	COG2080	2 iron, 2 sulfur cluster binding
K5X85_RS05735	COG4565	transcriptional regulatory protein
K5X85_RS05740	COG3290	protein histidine kinase activity
K5X85_RS05775	COG1063	alcohol dehydrogenase
K5X85_RS05785	COG0432	Pfam Uncharacterised protein family UPF0047
K5X85_RS05790	COG2072	flavoprotein involved in K transport
K5X85_RS05800	COG1132	(ABC) transporter
K5X85_RS05815	COG1132	(ABC) transporter
K5X85_RS05820	COG1132	(ABC) transporter
K5X85_RS05830	COG0254	rRNA binding
K5X85_RS05845	COG1946	Acyl-CoA thioesterase
K5X85_RS05855	COG2018	Roadblock/LC7 domain
K5X85_RS05920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5X85_RS05930	COG2115	Belongs to the xylose isomerase family
K5X85_RS05935	COG1070	Carbohydrate kinase
K5X85_RS05940	COG1846	Transcriptional regulator
K5X85_RS05940	COG1940	carbohydrate kinase activity
K5X85_RS05955	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS05960	COG1472	Belongs to the glycosyl hydrolase 3 family
K5X85_RS05970	COG0592	DNA-directed DNA polymerase activity
K5X85_RS05985	COG0714	Associated with various cellular activities
K5X85_RS06035	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS06040	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS06050	COG1396	sequence-specific DNA binding
K5X85_RS06050	COG3800	Transcriptional regulator
K5X85_RS06060	COG1793	dna ligase
K5X85_RS06070	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS06080	COG3424	synthase
K5X85_RS06085	COG2124	cytochrome p450
K5X85_RS06095	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS06105	COG0242	peptide deformylase activity
K5X85_RS06110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5X85_RS06115	COG3442	glutamine amidotransferase
K5X85_RS06120	COG0205	6-phosphofructokinase activity
K5X85_RS06135	COG3275	phosphorelay sensor kinase activity
K5X85_RS06140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5X85_RS06150	COG3279	Response regulator of the LytR AlgR family
K5X85_RS06155	COG1522	sequence-specific DNA binding
K5X85_RS06160	COG1834	amidinotransferase
K5X85_RS06165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5X85_RS06175	COG0477	Major facilitator Superfamily
K5X85_RS06195	COG0829	nickel cation binding
K5X85_RS06200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K5X85_RS06210	COG0804	urea catabolic process
K5X85_RS06215	COG0832	Belongs to the urease beta subunit family
K5X85_RS06220	COG0831	urea catabolic process
K5X85_RS06225	COG1309	transcriptional regulator
K5X85_RS06240	COG0740	serine-type endopeptidase activity
K5X85_RS06275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K5X85_RS06280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5X85_RS06285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K5X85_RS06290	COG2226	methyltransferase
K5X85_RS06310	COG0456	acetyltransferase
K5X85_RS06330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5X85_RS06335	COG3663	DNA glycosylase
K5X85_RS06355	COG4585	Histidine kinase
K5X85_RS06360	COG2197	response regulator
K5X85_RS06365	COG1940	carbohydrate kinase activity
K5X85_RS06370	COG2188	Transcriptional regulator
K5X85_RS06375	COG1595	DNA-templated transcription, initiation
K5X85_RS06380	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X85_RS06380	COG0596	Alpha beta hydrolase
K5X85_RS06410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5X85_RS06415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K5X85_RS06425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS06425	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K5X85_RS06465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5X85_RS06480	COG0626	cystathionine gamma-synthase activity
K5X85_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS06505	COG1522	sequence-specific DNA binding
K5X85_RS06510	COG0419	ATPase involved in DNA repair
K5X85_RS06515	COG0420	3'-5' exonuclease activity
K5X85_RS06520	COG1739	Uncharacterized protein family UPF0029
K5X85_RS06530	COG1832	CoA-binding protein
K5X85_RS06540	COG0640	Transcriptional regulator
K5X85_RS06560	COG0110	maltose O-acetyltransferase activity
K5X85_RS06595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5X85_RS06610	COG1968	undecaprenyl-diphosphatase activity
K5X85_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS06625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K5X85_RS06645	COG2318	DinB family
K5X85_RS06660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K5X85_RS06695	COG0723	plastoquinol--plastocyanin reductase activity
K5X85_RS06710	COG0697	spore germination
K5X85_RS06750	COG0384	phenazine biosynthesis protein PhzF
K5X85_RS06775	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K5X85_RS06780	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K5X85_RS06785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K5X85_RS06800	COG0725	ABC transporter, periplasmic molybdate-binding protein
K5X85_RS06820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5X85_RS06820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5X85_RS06830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5X85_RS06870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5X85_RS06900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5X85_RS06910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5X85_RS06915	COG1501	Belongs to the glycosyl hydrolase 31 family
K5X85_RS06925	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K5X85_RS06930	COG3706	GGDEF domain
K5X85_RS06935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5X85_RS06940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5X85_RS06955	COG2018	Roadblock/LC7 domain
K5X85_RS06980	COG1414	Transcriptional regulator
K5X85_RS06995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS07025	COG2814	Major facilitator Superfamily
K5X85_RS07030	COG4336	lyase activity
K5X85_RS07035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K5X85_RS07040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K5X85_RS07045	COG1984	allophanate hydrolase subunit 2
K5X85_RS07055	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS07060	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS07090	COG2364	Membrane
K5X85_RS07100	COG2270	Major facilitator Superfamily
K5X85_RS07115	COG1216	Glycosyl transferase, family 2
K5X85_RS07140	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS07190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K5X85_RS07195	COG0140	phosphoribosyl-ATP diphosphatase activity
K5X85_RS07200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K5X85_RS07205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5X85_RS07205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5X85_RS07210	COG3201	nicotinamide mononucleotide transporter
K5X85_RS07230	COG2223	nitrite transmembrane transporter activity
K5X85_RS07240	COG2233	PERMEase
K5X85_RS07265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5X85_RS07285	COG0531	amino acid
K5X85_RS07300	COG2390	Transcriptional regulator
K5X85_RS07305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5X85_RS07315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5X85_RS07330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5X85_RS07340	COG1758	RNA polymerase activity
K5X85_RS07345	COG0194	GDP metabolic process
K5X85_RS07355	COG0284	orotidine-5'-phosphate decarboxylase activity
K5X85_RS07360	COG0167	dihydroorotate dehydrogenase activity
K5X85_RS07365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5X85_RS07370	COG0505	Belongs to the CarA family
K5X85_RS07380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5X85_RS07385	COG0540	Belongs to the ATCase OTCase family
K5X85_RS07390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K5X85_RS07400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5X85_RS07405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5X85_RS07410	COG0006	proline dipeptidase activity
K5X85_RS07420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K5X85_RS07425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5X85_RS07430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5X85_RS07435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5X85_RS07445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5X85_RS07450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5X85_RS07470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5X85_RS07485	COG0124	histidyl-tRNA synthetase
K5X85_RS07495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5X85_RS07500	COG1196	nuclear chromosome segregation
K5X85_RS07505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5X85_RS07510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5X85_RS07515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5X85_RS07520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5X85_RS07530	COG2255	four-way junction helicase activity
K5X85_RS07535	COG0632	four-way junction helicase activity
K5X85_RS07540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K5X85_RS07545	COG0217	transcriptional regulatory protein
K5X85_RS07550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K5X85_RS07555	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K5X85_RS07565	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS07570	COG1560	Kdo2-lipid A biosynthetic process
K5X85_RS07575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5X85_RS07595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5X85_RS07610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5X85_RS07635	COG0395	ABC-type sugar transport system, permease component
K5X85_RS07640	COG1175	transmembrane transport
K5X85_RS07695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5X85_RS07750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5X85_RS07750	COG1648	precorrin-2 dehydrogenase activity
K5X85_RS07755	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K5X85_RS07775	COG2011	ABC-type metal ion transport system permease component
K5X85_RS07780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5X85_RS07805	COG0584	glycerophosphoryl diester phosphodiesterase
K5X85_RS07810	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS07810	COG0204	Acyl-transferase
K5X85_RS07815	COG0477	Major facilitator Superfamily
K5X85_RS07830	COG0165	Argininosuccinate lyase
K5X85_RS07860	COG1438	arginine binding
K5X85_RS07865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5X85_RS07870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5X85_RS07875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K5X85_RS07880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K5X85_RS07910	COG0697	spore germination
K5X85_RS07920	COG1649	PFAM Uncharacterised BCR, COG1649
K5X85_RS07945	COG0072	phenylalanine-tRNA ligase activity
K5X85_RS07945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5X85_RS07950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5X85_RS07955	COG5002	protein histidine kinase activity
K5X85_RS07960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5X85_RS07965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5X85_RS07970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5X85_RS07975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5X85_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS08020	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS08025	COG0174	glutamine synthetase
K5X85_RS08035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5X85_RS08060	COG4176	ABC-type proline glycine betaine transport system permease component
K5X85_RS08065	COG0517	IMP dehydrogenase activity
K5X85_RS08065	COG4175	Glycine betaine
K5X85_RS08070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5X85_RS08085	COG0564	pseudouridine synthase activity
K5X85_RS08120	COG0805	protein transport
K5X85_RS08125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5X85_RS08155	COG0545	Peptidyl-prolyl cis-trans isomerase
K5X85_RS08160	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K5X85_RS08170	COG1609	Transcriptional regulator
K5X85_RS08175	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K5X85_RS08180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K5X85_RS08195	COG4122	O-methyltransferase activity
K5X85_RS08200	COG1222	aaa ATPase
K5X85_RS08220	COG1994	Peptidase M50
K5X85_RS08220	COG0517	IMP dehydrogenase activity
K5X85_RS08230	COG2197	response regulator
K5X85_RS08235	COG4166	transmembrane transport
K5X85_RS08240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X85_RS08245	COG1410	methionine synthase
K5X85_RS08245	COG0646	methionine synthase
K5X85_RS08250	COG1414	Transcriptional regulator
K5X85_RS08255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5X85_RS08260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5X85_RS08265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5X85_RS08275	COG0215	cysteine-tRNA ligase activity
K5X85_RS08290	COG0588	phosphoglycerate mutase activity
K5X85_RS08295	COG0598	Magnesium transport protein CorA
K5X85_RS08305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS08310	COG0667	Aldo Keto reductase
K5X85_RS08340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X85_RS08350	COG3012	SEC-C Motif Domain Protein
K5X85_RS08355	COG2186	Transcriptional regulator
K5X85_RS08360	COG3265	gluconokinase activity
K5X85_RS08385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K5X85_RS08390	COG2149	membrane
K5X85_RS08430	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS08440	COG3876	Protein conserved in bacteria
K5X85_RS08460	COG0789	Transcriptional regulator
K5X85_RS08480	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS08490	COG0640	Transcriptional regulator
K5X85_RS08495	COG0697	spore germination
K5X85_RS08510	COG3842	ATPase activity
K5X85_RS08525	COG2851	Citrate transporter
K5X85_RS08530	COG0243	molybdopterin cofactor binding
K5X85_RS08535	COG1309	transcriptional regulator
K5X85_RS08545	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K5X85_RS08550	COG2188	Transcriptional regulator
K5X85_RS08585	COG1595	DNA-templated transcription, initiation
K5X85_RS08590	COG0515	serine threonine protein kinase
K5X85_RS08590	COG2815	serine threonine protein kinase
K5X85_RS08595	COG2755	lipolytic protein G-D-S-L family
K5X85_RS08600	COG0463	Glycosyl transferase, family 2
K5X85_RS08610	COG1649	PFAM Uncharacterised BCR, COG1649
K5X85_RS08610	COG0726	polysaccharide deacetylase
K5X85_RS08625	COG1725	Transcriptional regulator
K5X85_RS08640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K5X85_RS08640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5X85_RS08655	COG0662	Cupin 2, conserved barrel domain protein
K5X85_RS08655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5X85_RS08665	COG0587	DNA-directed DNA polymerase activity
K5X85_RS08690	COG1799	cell septum assembly
K5X85_RS08695	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS08700	COG0477	Major facilitator Superfamily
K5X85_RS08710	COG0671	phosphoesterase, PA-phosphatase related
K5X85_RS08735	COG1160	GTP binding
K5X85_RS08745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5X85_RS08760	COG0723	plastoquinol--plastocyanin reductase activity
K5X85_RS08795	COG1187	pseudouridine synthase activity
K5X85_RS08800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5X85_RS08805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5X85_RS08820	COG0686	Belongs to the AlaDH PNT family
K5X85_RS08830	COG0494	nUDIX hydrolase
K5X85_RS08835	COG0504	CTP synthase activity
K5X85_RS08840	COG3387	PFAM Glycoside hydrolase 15-related
K5X85_RS08850	COG0297	glycogen (starch) synthase activity
K5X85_RS08860	COG0497	DNA recombination
K5X85_RS08865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5X85_RS08885	COG1120	ATPase activity
K5X85_RS08890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS08895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS08900	COG0647	UMP catabolic process
K5X85_RS08935	COG2094	Belongs to the DNA glycosylase MPG family
K5X85_RS08945	COG1881	PFAM PEBP family protein
K5X85_RS08965	COG1119	ATPase activity
K5X85_RS08980	COG2197	response regulator
K5X85_RS08985	COG4585	Histidine kinase
K5X85_RS08990	COG4221	oxidoreductase activity
K5X85_RS09005	COG0842	Transport permease protein
K5X85_RS09005	COG1716	ATPase activity
K5X85_RS09005	COG1131	(ABC) transporter
K5X85_RS09015	COG0560	Phosphoserine phosphatase
K5X85_RS09015	COG3830	Belongs to the UPF0237 family
K5X85_RS09025	COG0588	phosphoglycerate mutase activity
K5X85_RS09040	COG2186	Transcriptional regulator
K5X85_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS09070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5X85_RS09090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K5X85_RS09095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5X85_RS09115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K5X85_RS09125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5X85_RS09140	COG3387	PFAM Glycoside hydrolase 15-related
K5X85_RS09180	COG1024	Enoyl-CoA hydratase
K5X85_RS09190	COG0488	(ABC) transporter
K5X85_RS09210	COG0235	Class ii aldolase
K5X85_RS09225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K5X85_RS09230	COG1492	cobalamin metabolic process
K5X85_RS09250	COG1797	cobyrinic acid a,c-diamide synthase activity
K5X85_RS09285	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
K5X85_RS09310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K5X85_RS09315	COG0456	acetyltransferase
K5X85_RS09320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K5X85_RS09325	COG1917	Cupin 2, conserved barrel domain protein
K5X85_RS09330	COG5285	phytanoyl-CoA dioxygenase
K5X85_RS09360	COG1414	Transcriptional regulator
K5X85_RS09375	COG4585	Histidine kinase
K5X85_RS09380	COG2197	response regulator
K5X85_RS09390	COG1595	DNA-templated transcription, initiation
K5X85_RS09415	COG4677	pectinesterase activity
K5X85_RS09420	COG3866	Pectate lyase
K5X85_RS09425	COG2755	lipolytic protein G-D-S-L family
K5X85_RS09440	COG3507	Belongs to the glycosyl hydrolase 43 family
K5X85_RS09455	COG0395	ABC-type sugar transport system, permease component
K5X85_RS09475	COG1802	Transcriptional regulator
K5X85_RS09495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5X85_RS09500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5X85_RS09505	COG1349	DNA-binding transcription factor activity
K5X85_RS09525	COG1063	alcohol dehydrogenase
K5X85_RS09535	COG1309	transcriptional regulator
K5X85_RS09545	COG1802	Transcriptional regulator
K5X85_RS09585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5X85_RS09600	COG2171	N-acyltransferase activity
K5X85_RS09605	COG3226	Transcriptional regulator
K5X85_RS09615	COG2151	metal-sulfur cluster biosynthetic enzyme
K5X85_RS09620	COG0822	iron-sulfur transferase activity
K5X85_RS09625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5X85_RS09630	COG0396	ATPase activity
K5X85_RS09640	COG0719	Fe-S assembly protein
K5X85_RS09655	COG2746	aminoglycoside 3-N-acetyltransferase activity
K5X85_RS09660	COG1131	(ABC) transporter
K5X85_RS09685	COG0109	protoheme IX farnesyltransferase activity
K5X85_RS09695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K5X85_RS09710	COG0363	glucosamine-6-phosphate deaminase activity
K5X85_RS09720	COG0148	phosphopyruvate hydratase activity
K5X85_RS09725	COG0395	ABC-type sugar transport system, permease component
K5X85_RS09730	COG1175	transmembrane transport
K5X85_RS09735	COG1653	transport
K5X85_RS09740	COG0366	Alpha amylase catalytic
K5X85_RS09745	COG1653	transport
K5X85_RS09750	COG1695	Transcriptional regulator
K5X85_RS09755	COG1136	(ABC) transporter
K5X85_RS09765	COG0166	Belongs to the GPI family
K5X85_RS09775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5X85_RS09780	COG0149	triose-phosphate isomerase activity
K5X85_RS09785	COG0126	phosphoglycerate kinase activity
K5X85_RS09790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5X85_RS09800	COG1481	regulation of sporulation
K5X85_RS09805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K5X85_RS09810	COG1660	Displays ATPase and GTPase activities
K5X85_RS09815	COG0322	excinuclease ABC activity
K5X85_RS09840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5X85_RS09855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K5X85_RS09860	COG1619	proteins homologs of microcin C7 resistance protein MccF
K5X85_RS09865	COG0387	Pfam Sodium calcium exchanger
K5X85_RS09885	COG0556	nucleotide-excision repair
K5X85_RS09895	COG0584	glycerophosphoryl diester phosphodiesterase
K5X85_RS09900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5X85_RS09910	COG2313	pseudouridylate synthase activity
K5X85_RS09920	COG2226	methyltransferase
K5X85_RS09925	COG0598	Magnesium transport protein CorA
K5X85_RS09975	COG0402	S-adenosylhomocysteine deaminase activity
K5X85_RS09995	COG2267	carboxylic ester hydrolase activity
K5X85_RS10010	COG2226	methyltransferase
K5X85_RS10025	COG0237	dephospho-CoA kinase activity
K5X85_RS10035	COG0539	negative regulation of cytoplasmic translation
K5X85_RS10040	COG2226	methyltransferase
K5X85_RS10045	COG1643	Atp-dependent helicase
K5X85_RS10075	COG2050	protein possibly involved in aromatic compounds catabolism
K5X85_RS10135	COG0737	Belongs to the 5'-nucleotidase family
K5X85_RS10155	COG0287	Prephenate dehydrogenase
K5X85_RS10155	COG1605	Chorismate mutase
K5X85_RS10170	COG2304	oxidoreductase activity
K5X85_RS10190	COG0067	glutamate synthase
K5X85_RS10190	COG0070	glutamate synthase
K5X85_RS10190	COG0069	glutamate synthase activity
K5X85_RS10220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K5X85_RS10225	COG2301	Belongs to the HpcH HpaI aldolase family
K5X85_RS10230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5X85_RS10240	COG0159	tryptophan synthase activity
K5X85_RS10245	COG0133	tryptophan synthase activity
K5X85_RS10255	COG0134	indole-3-glycerol-phosphate synthase activity
K5X85_RS10280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K5X85_RS10295	COG0107	imidazoleglycerol-phosphate synthase activity
K5X85_RS10300	COG0251	oxidation-reduction process
K5X85_RS10305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K5X85_RS10310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K5X85_RS10320	COG0131	Imidazoleglycerol-phosphate dehydratase
K5X85_RS10325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5X85_RS10330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5X85_RS10355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5X85_RS10375	COG1432	Conserved Protein
K5X85_RS10385	COG0587	DNA-directed DNA polymerase activity
K5X85_RS10435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5X85_RS10445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5X85_RS10450	COG3599	regulation of cell shape
K5X85_RS10460	COG1799	cell septum assembly
K5X85_RS10470	COG1496	oxidoreductase activity
K5X85_RS10475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5X85_RS10480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5X85_RS10485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5X85_RS10495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5X85_RS10500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5X85_RS10510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5X85_RS10515	COG0768	penicillin binding
K5X85_RS10525	COG0275	rRNA processing
K5X85_RS10535	COG0714	Associated with various cellular activities
K5X85_RS10555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5X85_RS10565	COG1129	ABC transporter
K5X85_RS10575	COG1309	transcriptional regulator
K5X85_RS10595	COG0352	thiamine-phosphate diphosphorylase activity
K5X85_RS10615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS10615	COG2022	thiamine diphosphate biosynthetic process
K5X85_RS10625	COG2022	thiamine diphosphate biosynthetic process
K5X85_RS10630	COG0515	serine threonine protein kinase
K5X85_RS10630	COG2815	serine threonine protein kinase
K5X85_RS10635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5X85_RS10640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K5X85_RS10645	COG2193	ferroxidase activity
K5X85_RS10655	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K5X85_RS10670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5X85_RS10675	COG0205	6-phosphofructokinase activity
K5X85_RS10680	COG2197	response regulator
K5X85_RS10685	COG4585	Histidine kinase
K5X85_RS10710	COG1940	carbohydrate kinase activity
K5X85_RS10720	COG0003	Pfam Anion-transporting ATPase
K5X85_RS10740	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS10760	COG3103	Sh3 type 3 domain protein
K5X85_RS10760	COG0791	NLP P60 protein
K5X85_RS10760	COG1388	LysM domain
K5X85_RS10790	COG2205	protein histidine kinase activity
K5X85_RS10795	COG0745	RESPONSE REGULATOR receiver
K5X85_RS10805	COG1929	Belongs to the glycerate kinase type-1 family
K5X85_RS10810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5X85_RS10815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5X85_RS10820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K5X85_RS10825	COG0723	plastoquinol--plastocyanin reductase activity
K5X85_RS10830	COG2010	Cytochrome c
K5X85_RS10835	COG1845	cytochrome c oxidase, subunit III
K5X85_RS10845	COG1376	ErfK ybiS ycfS ynhG family protein
K5X85_RS10855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K5X85_RS10860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K5X85_RS10870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X85_RS10890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K5X85_RS10900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5X85_RS10905	COG2197	response regulator
K5X85_RS10910	COG4585	Histidine kinase
K5X85_RS10930	COG2226	methyltransferase
K5X85_RS10935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5X85_RS10955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K5X85_RS10965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K5X85_RS10975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K5X85_RS10980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5X85_RS10985	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X85_RS10995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5X85_RS11015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5X85_RS11025	COG1090	epimerase
K5X85_RS11040	COG0321	lipoyl(octanoyl) transferase activity
K5X85_RS11045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K5X85_RS11065	COG0174	glutamine synthetase
K5X85_RS11100	COG0745	RESPONSE REGULATOR receiver
K5X85_RS11115	COG2197	response regulator
K5X85_RS11165	COG0366	Alpha amylase catalytic
K5X85_RS11170	COG3833	ABC-type maltose transport systems, permease component
K5X85_RS11175	COG1175	transmembrane transport
K5X85_RS11180	COG1653	transport
K5X85_RS11185	COG1609	Transcriptional regulator
K5X85_RS11195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5X85_RS11200	COG2161	toxin-antitoxin pair type II binding
K5X85_RS11205	COG4115	mRNA cleavage
K5X85_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS11220	COG3321	synthase
K5X85_RS11220	COG0604	alcohol dehydrogenase
K5X85_RS11225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5X85_RS11225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5X85_RS11240	COG0174	glutamine synthetase
K5X85_RS11265	COG2814	Major facilitator Superfamily
K5X85_RS11275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K5X85_RS11295	COG1994	Peptidase M50
K5X85_RS11355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS11360	COG1120	ATPase activity
K5X85_RS11385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5X85_RS11390	COG2814	Major facilitator Superfamily
K5X85_RS11400	COG3540	Alkaline phosphatase
K5X85_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS11455	COG0789	Transcriptional regulator
K5X85_RS11465	COG3022	response to hydroperoxide
K5X85_RS11470	COG0800	Aldolase
K5X85_RS11485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5X85_RS11500	COG2030	dehydratase
K5X85_RS11505	COG1131	(ABC) transporter
K5X85_RS11515	COG4585	Histidine kinase
K5X85_RS11520	COG2197	response regulator
K5X85_RS11530	COG0477	Major facilitator Superfamily
K5X85_RS11540	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5X85_RS11540	COG2247	cell wall binding repeat
K5X85_RS11565	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS11570	COG1309	transcriptional regulator
K5X85_RS11590	COG3845	ABC transporter
K5X85_RS11625	COG0477	Major facilitator Superfamily
K5X85_RS11630	COG4122	O-methyltransferase activity
K5X85_RS11670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X85_RS11740	COG4585	Histidine kinase
K5X85_RS11745	COG0586	Pfam SNARE associated Golgi protein
K5X85_RS11755	COG1358	cellular component organization or biogenesis
K5X85_RS11800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5X85_RS11805	COG0477	Major facilitator Superfamily
K5X85_RS11820	COG0667	Aldo Keto reductase
K5X85_RS11825	COG0789	Transcriptional regulator
K5X85_RS11865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5X85_RS11870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5X85_RS11875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS11915	COG1764	response to oxidative stress
K5X85_RS11920	COG2130	NADP-dependent
K5X85_RS11955	COG1129	ABC transporter
K5X85_RS11960	COG4214	carbohydrate transport
K5X85_RS11970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5X85_RS11975	COG3507	Belongs to the glycosyl hydrolase 43 family
K5X85_RS11980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5X85_RS12000	COG0395	ABC-type sugar transport system, permease component
K5X85_RS12005	COG1175	transmembrane transport
K5X85_RS12035	COG3386	PFAM SMP-30 Gluconolaconase
K5X85_RS12040	COG1414	Transcriptional regulator
K5X85_RS12055	COG2186	Transcriptional regulator
K5X85_RS12065	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS12070	COG0825	malonyl-CoA metabolic process
K5X85_RS12070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5X85_RS12075	COG1404	Belongs to the peptidase S8 family
K5X85_RS12105	COG1077	Cell shape determining protein MreB Mrl
K5X85_RS12145	COG1070	Carbohydrate kinase
K5X85_RS12170	COG0358	DNA primase activity
K5X85_RS12180	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K5X85_RS12190	COG2949	membrane
K5X85_RS12195	COG0243	molybdopterin cofactor binding
K5X85_RS12225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5X85_RS12230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5X85_RS12230	COG2146	nitrite reductase [NAD(P)H] activity
K5X85_RS12250	COG0574	Belongs to the PEP-utilizing enzyme family
K5X85_RS12250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5X85_RS12285	COG0477	Major facilitator Superfamily
K5X85_RS12295	COG0423	glycine-tRNA ligase activity
K5X85_RS12300	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5X85_RS12300	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5X85_RS12305	COG1121	(ABC) transporter
K5X85_RS12310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5X85_RS12320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5X85_RS12325	COG1381	Involved in DNA repair and RecF pathway recombination
K5X85_RS12360	COG2197	response regulator
K5X85_RS12365	COG4585	Histidine kinase
K5X85_RS12370	COG2409	Drug exporters of the RND superfamily
K5X85_RS12420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5X85_RS12445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5X85_RS12455	COG2315	Protein conserved in bacteria
K5X85_RS12490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5X85_RS12495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X85_RS12505	COG4948	Mandelate Racemase Muconate Lactonizing
K5X85_RS12510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5X85_RS12515	COG1414	Transcriptional regulator
K5X85_RS12525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5X85_RS12530	COG1234	tRNA 3'-trailer cleavage
K5X85_RS12535	COG0537	adenosine 5'-monophosphoramidase activity
K5X85_RS12540	COG4946	Tricorn protease homolog
K5X85_RS12540	COG0793	Belongs to the peptidase S41A family
K5X85_RS12560	COG0484	heat shock protein binding
K5X85_RS12565	COG1420	regulation of RNA biosynthetic process
K5X85_RS12585	COG3293	Transposase
K5X85_RS12605	COG0481	GTPase activity
K5X85_RS12610	COG0268	Binds directly to 16S ribosomal RNA
K5X85_RS12625	COG2353	YceI-like domain
K5X85_RS12635	COG1234	tRNA 3'-trailer cleavage
K5X85_RS12640	COG1555	photosystem II stabilization
K5X85_RS12645	COG1307	EDD domain protein, DegV family
K5X85_RS12655	COG0495	leucyl-tRNA aminoacylation
K5X85_RS12665	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K5X85_RS12690	COG0588	phosphoglycerate mutase activity
K5X85_RS12695	COG0799	negative regulation of ribosome biogenesis
K5X85_RS12705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5X85_RS12720	COG0501	Belongs to the peptidase M48B family
K5X85_RS12735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5X85_RS12745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5X85_RS12760	COG1216	Glycosyl transferase, family 2
K5X85_RS12765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X85_RS12765	COG0463	Glycosyl transferase, family 2
K5X85_RS12770	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS12775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5X85_RS12780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5X85_RS12785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5X85_RS12790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5X85_RS12795	COG0371	Dehydrogenase
K5X85_RS12800	COG1530	ribonuclease E activity
K5X85_RS12820	COG0772	Belongs to the SEDS family
K5X85_RS12825	COG0768	penicillin binding
K5X85_RS12840	COG1077	Cell shape determining protein MreB Mrl
K5X85_RS12845	COG0105	UTP biosynthetic process
K5X85_RS12855	COG0285	dihydrofolate synthase activity
K5X85_RS12860	COG0525	valine-tRNA ligase activity
K5X85_RS12870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5X85_RS12875	COG0740	serine-type endopeptidase activity
K5X85_RS12880	COG0740	serine-type endopeptidase activity
K5X85_RS12885	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5X85_RS12905	COG3594	Acyltransferase
K5X85_RS12920	COG4552	Acetyltransferase involved in intracellular survival and related
K5X85_RS12935	COG1113	amino acid transport
K5X85_RS12940	COG1268	BioY protein
K5X85_RS12945	COG1113	amino acid transport
K5X85_RS12950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5X85_RS12960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5X85_RS13020	COG0697	spore germination
K5X85_RS13025	COG1846	Transcriptional regulator
K5X85_RS13050	COG0668	transmembrane transport
K5X85_RS13070	COG1486	melibiose metabolic process
K5X85_RS13085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5X85_RS13115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K5X85_RS13135	COG1136	(ABC) transporter
K5X85_RS13135	COG0577	efflux transmembrane transporter activity
K5X85_RS13160	COG0629	single-stranded DNA binding
K5X85_RS13180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5X85_RS13195	COG2304	oxidoreductase activity
K5X85_RS13225	COG0297	glycogen (starch) synthase activity
K5X85_RS13230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5X85_RS13240	COG0728	peptidoglycan biosynthetic process
K5X85_RS13250	COG0297	glycogen (starch) synthase activity
K5X85_RS13270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5X85_RS13340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5X85_RS13365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5X85_RS13375	COG0640	Transcriptional regulator
K5X85_RS13380	COG1595	DNA-templated transcription, initiation
K5X85_RS13390	COG1609	Transcriptional regulator
K5X85_RS13395	COG1129	ABC transporter
K5X85_RS13405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X85_RS13410	COG1869	D-ribose catabolic process
K5X85_RS13425	COG0673	inositol 2-dehydrogenase activity
K5X85_RS13430	COG1609	Transcriptional regulator
K5X85_RS13440	COG0488	(ABC) transporter
K5X85_RS13455	COG1472	Belongs to the glycosyl hydrolase 3 family
K5X85_RS13510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K5X85_RS13515	COG2356	endonuclease I
K5X85_RS13520	COG0028	Belongs to the TPP enzyme family
K5X85_RS13550	COG1946	Acyl-CoA thioesterase
K5X85_RS13560	COG1309	transcriptional regulator
K5X85_RS13565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5X85_RS13580	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS13600	COG3486	L-lysine 6-monooxygenase (NADPH) activity
K5X85_RS13630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5X85_RS13635	COG0589	response to stress
K5X85_RS13645	COG4977	sequence-specific DNA binding
K5X85_RS13650	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K5X85_RS13675	COG0395	ABC-type sugar transport system, permease component
K5X85_RS13690	COG0745	RESPONSE REGULATOR receiver
K5X85_RS13700	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K5X85_RS13740	COG1846	Transcriptional regulator
K5X85_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS13780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5X85_RS13780	COG0596	Alpha beta hydrolase
K5X85_RS13800	COG0477	Major facilitator Superfamily
K5X85_RS13815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS13860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5X85_RS13870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5X85_RS13875	COG0765	amino acid transport
K5X85_RS13880	COG0765	amino acid transport
K5X85_RS13885	COG1126	abc transporter atp-binding protein
K5X85_RS13900	COG3397	chitin binding
K5X85_RS13970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X85_RS13975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS13980	COG2188	Transcriptional regulator
K5X85_RS14000	COG0673	inositol 2-dehydrogenase activity
K5X85_RS14005	COG4702	Belongs to the UPF0303 family
K5X85_RS14080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5X85_RS14100	COG2814	Major facilitator Superfamily
K5X85_RS14105	COG2733	membrane
K5X85_RS14135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K5X85_RS14175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K5X85_RS14185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5X85_RS14190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5X85_RS14195	COG1263	PTS System
K5X85_RS14200	COG1263	PTS System
K5X85_RS14205	COG1234	tRNA 3'-trailer cleavage
K5X85_RS14230	COG1113	amino acid transport
K5X85_RS14240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K5X85_RS14250	COG1335	isochorismatase
K5X85_RS14275	COG1714	RDD family
K5X85_RS14290	COG0277	FAD linked oxidase domain protein
K5X85_RS14300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K5X85_RS14310	COG1174	glycine betaine transport
K5X85_RS14320	COG1174	glycine betaine transport
K5X85_RS14330	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5X85_RS14360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K5X85_RS14375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K5X85_RS14380	COG0395	ABC-type sugar transport system, permease component
K5X85_RS14400	COG1678	Uncharacterized ACR, COG1678
K5X85_RS14405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5X85_RS14410	COG0776	regulation of translation
K5X85_RS14420	COG3973	AAA domain
K5X85_RS14445	COG2223	nitrite transmembrane transporter activity
K5X85_RS14480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5X85_RS14485	COG0793	Belongs to the peptidase S41A family
K5X85_RS14495	COG2884	Cell division ATP-binding protein ftsE
K5X85_RS14510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K5X85_RS14515	COG0515	serine threonine protein kinase
K5X85_RS14520	COG0515	serine threonine protein kinase
K5X85_RS14535	COG1175	transmembrane transport
K5X85_RS14540	COG0395	ABC-type sugar transport system, permease component
K5X85_RS14545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X85_RS14550	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X85_RS14570	COG1764	response to oxidative stress
K5X85_RS14575	COG1846	Transcriptional regulator
K5X85_RS14600	COG1134	teichoic acid transport
K5X85_RS14605	COG2902	Dehydrogenase
K5X85_RS14625	COG0653	protein targeting
K5X85_RS14635	COG3214	Protein conserved in bacteria
K5X85_RS14640	COG2197	response regulator
K5X85_RS14645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5X85_RS14655	COG0823	Involved in the tonB-independent uptake of proteins
K5X85_RS14660	COG5000	phosphorelay sensor kinase activity
K5X85_RS14660	COG5002	protein histidine kinase activity
K5X85_RS14665	COG0745	RESPONSE REGULATOR receiver
K5X85_RS14670	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5X85_RS14690	COG0714	Associated with various cellular activities
K5X85_RS14730	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K5X85_RS14740	COG1482	cell wall glycoprotein biosynthetic process
K5X85_RS14750	COG2835	tetraacyldisaccharide 4'-kinase activity
K5X85_RS14755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5X85_RS14760	COG1620	l-lactate permease
K5X85_RS14795	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K5X85_RS14800	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
K5X85_RS14800	COG0778	Nitroreductase
K5X85_RS14825	COG1316	TRANSCRIPTIONal
K5X85_RS14830	COG1316	TRANSCRIPTIONal
K5X85_RS14835	COG1316	TRANSCRIPTIONal
K5X85_RS14840	COG1316	TRANSCRIPTIONal
K5X85_RS14855	COG1316	TRANSCRIPTIONal
K5X85_RS14860	COG1316	TRANSCRIPTIONal
K5X85_RS14875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K5X85_RS14910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5X85_RS14925	COG2205	protein histidine kinase activity
K5X85_RS14930	COG0745	RESPONSE REGULATOR receiver
K5X85_RS14935	COG3104	oligopeptide transport
K5X85_RS14945	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS14950	COG1191	sigma factor activity
K5X85_RS14960	COG1228	amidohydrolase
K5X85_RS14970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X85_RS14975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5X85_RS15005	COG2755	lipolytic protein G-D-S-L family
K5X85_RS15010	COG0183	Belongs to the thiolase family
K5X85_RS15045	COG1136	(ABC) transporter
K5X85_RS15050	COG0577	efflux transmembrane transporter activity
K5X85_RS15055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5X85_RS15060	COG1252	NADH dehydrogenase
K5X85_RS15080	COG0148	phosphopyruvate hydratase activity
K5X85_RS15155	COG0577	efflux transmembrane transporter activity
K5X85_RS15160	COG1136	(ABC) transporter
K5X85_RS15165	COG0477	Major facilitator Superfamily
K5X85_RS15175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5X85_RS15205	COG4585	Histidine kinase
K5X85_RS15210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K5X85_RS15215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5X85_RS15220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5X85_RS15225	COG0193	aminoacyl-tRNA hydrolase activity
K5X85_RS15235	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K5X85_RS15245	COG1309	transcriptional regulator
K5X85_RS15255	COG4106	trans-aconitate 2-methyltransferase activity
K5X85_RS15265	COG2197	response regulator
K5X85_RS15275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5X85_RS15315	COG0488	(ABC) transporter
K5X85_RS15320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5X85_RS15325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5X85_RS15335	COG0084	hydrolase, TatD family'
K5X85_RS15370	COG0310	cobalt ion transport
K5X85_RS15380	COG1122	ATPase activity
K5X85_RS15385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5X85_RS15395	COG0442	prolyl-tRNA aminoacylation
K5X85_RS15400	COG2409	Drug exporters of the RND superfamily
K5X85_RS15410	COG0793	Belongs to the peptidase S41A family
K5X85_RS15410	COG4946	Tricorn protease homolog
K5X85_RS15425	COG2267	carboxylic ester hydrolase activity
K5X85_RS15430	COG2072	flavoprotein involved in K transport
K5X85_RS15460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5X85_RS15465	COG0315	cyclic pyranopterin monophosphate synthase activity
K5X85_RS15465	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5X85_RS15470	COG0315	cyclic pyranopterin monophosphate synthase activity
K5X85_RS15480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5X85_RS15485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5X85_RS15510	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K5X85_RS15520	COG1970	mechanosensitive ion channel activity
K5X85_RS15535	COG3191	aminopeptidase activity
K5X85_RS15560	COG1349	DNA-binding transcription factor activity
K5X85_RS15565	COG0477	Major facilitator Superfamily
K5X85_RS15580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5X85_RS15585	COG1247	-acetyltransferase
K5X85_RS15590	COG3384	dioxygenase
K5X85_RS15595	COG1846	Transcriptional regulator
K5X85_RS15615	COG1414	Transcriptional regulator
K5X85_RS15630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5X85_RS15645	COG2188	Transcriptional regulator
K5X85_RS15665	COG1309	transcriptional regulator
K5X85_RS15670	COG4257	antibiotic catabolic process
K5X85_RS15680	COG2208	phosphoserine phosphatase activity
K5X85_RS15695	COG0386	Belongs to the glutathione peroxidase family
K5X85_RS15720	COG1686	Belongs to the peptidase S11 family
K5X85_RS15735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5X85_RS15735	COG0515	serine threonine protein kinase
K5X85_RS15740	COG0515	serine threonine protein kinase
K5X85_RS15740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5X85_RS15755	COG0583	DNA-binding transcription factor activity
K5X85_RS15785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K5X85_RS15805	COG3903	Transcriptional regulator
K5X85_RS15805	COG3629	intracellular signal transduction
K5X85_RS15815	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5X85_RS15815	COG0515	serine threonine protein kinase
K5X85_RS15825	COG1309	transcriptional regulator
K5X85_RS15845	COG0259	pyridoxamine-phosphate oxidase activity
K5X85_RS15855	COG2072	flavoprotein involved in K transport
K5X85_RS15860	COG2271	Major facilitator Superfamily
K5X85_RS15880	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS15945	COG0596	Alpha beta hydrolase
K5X85_RS15945	COG2945	thiolester hydrolase activity
K5X85_RS15955	COG4821	SIS domain
K5X85_RS15975	COG0259	pyridoxamine-phosphate oxidase activity
K5X85_RS15990	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS16005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5X85_RS16020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5X85_RS16020	COG0515	serine threonine protein kinase
K5X85_RS16045	COG0247	lactate metabolic process
K5X85_RS16045	COG0277	FAD linked oxidase domain protein
K5X85_RS16050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K5X85_RS16090	COG0667	Aldo Keto reductase
K5X85_RS16115	COG2252	PERMEase
K5X85_RS16130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5X85_RS16145	COG2814	Major facilitator Superfamily
K5X85_RS16155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5X85_RS16160	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K5X85_RS16195	COG1061	Type III restriction enzyme res subunit
K5X85_RS16205	COG3973	AAA domain
K5X85_RS16245	COG1737	Transcriptional regulator
K5X85_RS16250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K5X85_RS16280	COG0459	protein refolding
K5X85_RS16285	COG1278	Cold shock
K5X85_RS16300	COG0463	Glycosyl transferase, family 2
K5X85_RS16330	COG1940	carbohydrate kinase activity
K5X85_RS16340	COG1105	Belongs to the carbohydrate kinase PfkB family
K5X85_RS16350	COG3300	MHYT domain
K5X85_RS16350	COG5001	Diguanylate cyclase
K5X85_RS16375	COG2197	response regulator
K5X85_RS16380	COG4585	Histidine kinase
K5X85_RS16420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS16420	COG0723	plastoquinol--plastocyanin reductase activity
K5X85_RS16445	COG0464	growth
K5X85_RS16540	COG3842	ATPase activity
K5X85_RS16565	COG0215	cysteine-tRNA ligase activity
K5X85_RS16570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K5X85_RS16575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K5X85_RS16580	COG1329	Transcriptional regulator
K5X85_RS16595	COG5002	protein histidine kinase activity
K5X85_RS16630	COG2318	DinB family
K5X85_RS16635	COG0222	ribosome binding
K5X85_RS16640	COG0588	phosphoglycerate mutase activity
K5X85_RS16665	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS16700	COG0515	serine threonine protein kinase
K5X85_RS16700	COG2815	serine threonine protein kinase
K5X85_RS16705	COG1733	regulation of RNA biosynthetic process
K5X85_RS16710	COG2084	Dehydrogenase
K5X85_RS16725	COG0546	phosphoglycolate phosphatase activity
K5X85_RS16730	COG0546	phosphoglycolate phosphatase activity
K5X85_RS16735	COG2186	Transcriptional regulator
K5X85_RS16750	COG4552	Acetyltransferase involved in intracellular survival and related
K5X85_RS16765	COG1490	D-aminoacyl-tRNA deacylase activity
K5X85_RS16775	COG0735	belongs to the Fur family
K5X85_RS16780	COG3485	protocatechuate 3,4-dioxygenase
K5X85_RS16795	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS16815	COG2897	thiosulfate sulfurtransferase activity
K5X85_RS16840	COG0745	RESPONSE REGULATOR receiver
K5X85_RS16845	COG1609	Transcriptional regulator
K5X85_RS16850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5X85_RS16855	COG0745	RESPONSE REGULATOR receiver
K5X85_RS16885	COG0737	Belongs to the 5'-nucleotidase family
K5X85_RS16890	COG0456	acetyltransferase
K5X85_RS16905	COG1131	(ABC) transporter
K5X85_RS16920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K5X85_RS16930	COG0494	nUDIX hydrolase
K5X85_RS16930	COG0406	alpha-ribazole phosphatase activity
K5X85_RS16950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5X85_RS16955	COG0306	phosphate transporter
K5X85_RS16965	COG1937	Protein conserved in bacteria
K5X85_RS16985	COG0671	phosphoesterase, PA-phosphatase related
K5X85_RS16990	COG0739	heme binding
K5X85_RS16990	COG0741	lytic transglycosylase activity
K5X85_RS16990	COG1196	nuclear chromosome segregation
K5X85_RS17030	COG4585	Histidine kinase
K5X85_RS17035	COG2197	response regulator
K5X85_RS17070	COG1252	NADH dehydrogenase
K5X85_RS17095	COG0579	oxidoreductase
K5X85_RS17100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5X85_RS17130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5X85_RS17130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5X85_RS17145	COG0513	Belongs to the DEAD box helicase family
K5X85_RS17180	COG1643	Atp-dependent helicase
K5X85_RS17215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5X85_RS17255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5X85_RS17260	COG0047	phosphoribosylformylglycinamidine synthase activity
K5X85_RS17265	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5X85_RS17295	COG3851	Histidine kinase
K5X85_RS17300	COG2197	response regulator
K5X85_RS17310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5X85_RS17325	COG0151	Belongs to the GarS family
K5X85_RS17345	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS17350	COG0583	DNA-binding transcription factor activity
K5X85_RS17360	COG1276	copper resistance
K5X85_RS17360	COG2372	response to copper ion
K5X85_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS17420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5X85_RS17455	COG1191	sigma factor activity
K5X85_RS17460	COG1191	sigma factor activity
K5X85_RS17480	COG2353	YceI-like domain
K5X85_RS17500	COG3467	pyridoxamine 5'-phosphate
K5X85_RS17510	COG0477	Major facilitator Superfamily
K5X85_RS17515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K5X85_RS17525	COG2205	protein histidine kinase activity
K5X85_RS17530	COG0745	RESPONSE REGULATOR receiver
K5X85_RS17545	COG1733	regulation of RNA biosynthetic process
K5X85_RS17550	COG0768	penicillin binding
K5X85_RS17575	COG0784	Response regulator, receiver
K5X85_RS17580	COG1309	transcriptional regulator
K5X85_RS17585	COG2814	Major facilitator Superfamily
K5X85_RS17590	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS17595	COG1595	DNA-templated transcription, initiation
K5X85_RS17625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5X85_RS17635	COG2188	Transcriptional regulator
K5X85_RS17710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5X85_RS17745	COG0006	proline dipeptidase activity
K5X85_RS17765	COG1999	signal sequence binding
K5X85_RS17780	COG2837	iron assimilation
K5X85_RS17785	COG0077	Prephenate dehydratase
K5X85_RS17790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5X85_RS17795	COG0561	phosphatase activity
K5X85_RS17835	COG0561	phosphatase activity
K5X85_RS17840	COG0739	heme binding
K5X85_RS17850	COG4988	ABC transporter
K5X85_RS17855	COG1294	oxidase, subunit
K5X85_RS17860	COG1271	oxidase subunit
K5X85_RS17870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5X85_RS17875	COG1609	Transcriptional regulator
K5X85_RS17890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K5X85_RS17915	COG0662	Cupin 2, conserved barrel domain protein
K5X85_RS17920	COG1950	PFAM Membrane protein of
K5X85_RS17925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5X85_RS17930	COG0626	cystathionine gamma-synthase activity
K5X85_RS17955	COG2814	Major facilitator Superfamily
K5X85_RS17975	COG0305	Participates in initiation and elongation during chromosome replication
K5X85_RS17985	COG0359	binds to the 23S rRNA
K5X85_RS17990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5X85_RS17995	COG0629	single-stranded DNA binding
K5X85_RS18000	COG0360	Binds together with S18 to 16S ribosomal RNA
K5X85_RS18025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5X85_RS18050	COG0617	tRNA 3'-terminal CCA addition
K5X85_RS18070	COG1595	DNA-templated transcription, initiation
K5X85_RS18080	COG0492	ferredoxin-NADP+ reductase activity
K5X85_RS18085	COG3118	belongs to the thioredoxin family
K5X85_RS18100	COG1192	Involved in chromosome partitioning
K5X85_RS18105	COG0357	Ribosomal RNA small subunit methyltransferase G
K5X85_RS18115	COG0706	membrane insertase activity
K5X85_RS18120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5X85_RS18125	COG0594	ribonuclease P activity
K5X85_RS18130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5X85_RS18135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5X85_RS18140	COG0592	DNA-directed DNA polymerase activity
K5X85_RS18145	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5X85_RS18150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5X85_RS18155	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
K5X85_RS18160	COG0187	DNA topoisomerase II activity
K5X85_RS18165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5X85_RS18180	COG0582	viral genome integration into host DNA
K5X85_RS18235	COG2188	Transcriptional regulator
K5X85_RS18240	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5X85_RS18250	COG4249	Peptidase C14 caspase catalytic subunit p20
K5X85_RS18250	COG2319	Wd-40 repeat
K5X85_RS18295	COG0515	serine threonine protein kinase
K5X85_RS18310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K5X85_RS18315	COG0431	NADPH-dependent FMN reductase
K5X85_RS18320	COG1045	serine acetyltransferase
K5X85_RS18335	COG0151	Belongs to the GarS family
K5X85_RS18345	COG1942	4-Oxalocrotonate Tautomerase
K5X85_RS18380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5X85_RS18395	COG0705	Rhomboid family
K5X85_RS18420	COG3764	Sortase (surface protein transpeptidase)
K5X85_RS18425	COG3764	Sortase (surface protein transpeptidase)
K5X85_RS18430	COG0515	serine threonine protein kinase
K5X85_RS18435	COG0768	penicillin binding
K5X85_RS18450	COG1716	ATPase activity
K5X85_RS18455	COG1716	ATPase activity
K5X85_RS18505	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5X85_RS18510	COG1309	transcriptional regulator
K5X85_RS18515	COG1522	sequence-specific DNA binding
K5X85_RS18560	COG0604	alcohol dehydrogenase
K5X85_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS18560	COG3321	synthase
K5X85_RS18575	COG0515	serine threonine protein kinase
K5X85_RS18580	COG0515	serine threonine protein kinase
K5X85_RS18600	COG0022	dehydrogenase e1 component
K5X85_RS18605	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X85_RS18625	COG2186	Transcriptional regulator
K5X85_RS18660	COG1362	aminopeptidase activity
K5X85_RS18665	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS18675	COG1741	Belongs to the pirin family
K5X85_RS18690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5X85_RS18710	COG0326	Molecular chaperone. Has ATPase activity
K5X85_RS18720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5X85_RS18770	COG1653	transport
K5X85_RS18795	COG0366	Alpha amylase catalytic
K5X85_RS18820	COG0583	DNA-binding transcription factor activity
K5X85_RS18880	COG0513	Belongs to the DEAD box helicase family
K5X85_RS18885	COG1278	Cold shock
K5X85_RS18920	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS18920	COG2172	sigma factor antagonist activity
K5X85_RS18920	COG2208	phosphoserine phosphatase activity
K5X85_RS18925	COG0475	glutathione-regulated potassium exporter activity
K5X85_RS18925	COG0569	domain protein
K5X85_RS18945	COG0640	Transcriptional regulator
K5X85_RS18995	COG0717	Belongs to the dCTP deaminase family
K5X85_RS19000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K5X85_RS19010	COG2181	nitrate reductase activity
K5X85_RS19010	COG0247	lactate metabolic process
K5X85_RS19015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5X85_RS19020	COG0443	Heat shock 70 kDa protein
K5X85_RS19025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5X85_RS19030	COG0484	heat shock protein binding
K5X85_RS19035	COG0789	Transcriptional regulator
K5X85_RS19065	COG1132	(ABC) transporter
K5X85_RS19095	COG2226	methyltransferase
K5X85_RS19100	COG0612	Peptidase, M16
K5X85_RS19115	COG4213	ABC transporter substrate-binding protein
K5X85_RS19140	COG0542	response to heat
K5X85_RS19160	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K5X85_RS19165	COG4585	Histidine kinase
K5X85_RS19170	COG2197	response regulator
K5X85_RS19185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K5X85_RS19190	COG0191	fructose-bisphosphate aldolase activity
K5X85_RS19195	COG0477	Major facilitator Superfamily
K5X85_RS19210	COG3844	kynureninase activity
K5X85_RS19235	COG4585	Histidine kinase
K5X85_RS19240	COG2197	response regulator
K5X85_RS19245	COG4585	Histidine kinase
K5X85_RS19250	COG2197	response regulator
K5X85_RS19260	COG3559	Exporter of polyketide antibiotics
K5X85_RS19265	COG1131	(ABC) transporter
K5X85_RS19280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5X85_RS19295	COG1595	DNA-templated transcription, initiation
K5X85_RS19310	COG1802	Transcriptional regulator
K5X85_RS19320	COG0693	protein deglycase activity
K5X85_RS19335	COG2319	Wd-40 repeat
K5X85_RS19335	COG4249	Peptidase C14 caspase catalytic subunit p20
K5X85_RS19350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5X85_RS19355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5X85_RS19375	COG1595	DNA-templated transcription, initiation
K5X85_RS19400	COG1585	Membrane protein implicated in regulation of membrane protease activity
K5X85_RS19420	COG3655	Transcriptional regulator
K5X85_RS19440	COG3263	regulation of cellular component size
K5X85_RS19455	COG0515	serine threonine protein kinase
K5X85_RS19470	COG1132	(ABC) transporter
K5X85_RS19475	COG1132	(ABC) transporter
K5X85_RS19480	COG2197	response regulator
K5X85_RS19485	COG1115	amino acid carrier protein
K5X85_RS19505	COG2255	four-way junction helicase activity
K5X85_RS19535	COG1408	metallophosphoesterase
K5X85_RS19545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5X85_RS19555	COG0003	Pfam Anion-transporting ATPase
K5X85_RS19570	COG0251	oxidation-reduction process
K5X85_RS19575	COG0596	Alpha beta hydrolase
K5X85_RS19585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5X85_RS19615	COG2267	carboxylic ester hydrolase activity
K5X85_RS19625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5X85_RS19630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5X85_RS19635	COG0659	secondary active sulfate transmembrane transporter activity
K5X85_RS19695	COG1205	dead DEAH box helicase
K5X85_RS19695	COG1111	helicase
K5X85_RS19700	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS19705	COG2172	sigma factor antagonist activity
K5X85_RS19710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K5X85_RS19720	COG2264	protein methyltransferase activity
K5X85_RS19730	COG1754	DNA topoisomerase type I activity
K5X85_RS19730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5X85_RS19735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5X85_RS19740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5X85_RS19760	COG3629	intracellular signal transduction
K5X85_RS19760	COG3903	Transcriptional regulator
K5X85_RS19785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5X85_RS19790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5X85_RS19795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5X85_RS19800	COG0254	rRNA binding
K5X85_RS19810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5X85_RS19830	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS19850	COG0076	glutamate decarboxylase activity
K5X85_RS19855	COG0789	Transcriptional regulator
K5X85_RS19860	COG0393	Putative heavy-metal-binding
K5X85_RS19865	COG0586	Pfam SNARE associated Golgi protein
K5X85_RS19875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K5X85_RS19880	COG2027	D-alanyl-D-alanine carboxypeptidase
K5X85_RS19890	COG0037	tRNA processing
K5X85_RS19905	COG0302	gtp cyclohydrolase
K5X85_RS19920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5X85_RS19935	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K5X85_RS19935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5X85_RS19960	COG0649	NAD binding
K5X85_RS19975	COG2197	response regulator
K5X85_RS19980	COG1660	Displays ATPase and GTPase activities
K5X85_RS20005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K5X85_RS20010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K5X85_RS20020	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K5X85_RS20040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K5X85_RS20070	COG0739	heme binding
K5X85_RS20085	COG2205	protein histidine kinase activity
K5X85_RS20090	COG0745	RESPONSE REGULATOR receiver
K5X85_RS20100	COG1595	DNA-templated transcription, initiation
K5X85_RS20105	COG1194	a g-specific adenine glycosylase
K5X85_RS20110	COG4585	Histidine kinase
K5X85_RS20120	COG0671	phosphoesterase, PA-phosphatase related
K5X85_RS20130	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K5X85_RS20150	COG0248	Ppx GppA phosphatase
K5X85_RS20155	COG1082	Xylose isomerase domain protein TIM barrel
K5X85_RS20160	COG1309	transcriptional regulator
K5X85_RS20165	COG0129	dihydroxy-acid dehydratase activity
K5X85_RS20170	COG0515	serine threonine protein kinase
K5X85_RS20170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5X85_RS20195	COG0842	Transport permease protein
K5X85_RS20195	COG1129	ABC transporter
K5X85_RS20205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5X85_RS20215	COG0180	Tryptophanyl-tRNA synthetase
K5X85_RS20235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5X85_RS20245	COG2223	nitrite transmembrane transporter activity
K5X85_RS20250	COG0123	including yeast histone deacetylase and acetoin utilization protein
K5X85_RS20300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5X85_RS20305	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K5X85_RS20310	COG0181	hydroxymethylbilane synthase activity
K5X85_RS20315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5X85_RS20315	COG1648	precorrin-2 dehydrogenase activity
K5X85_RS20330	COG0113	porphobilinogen synthase activity
K5X85_RS20350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5X85_RS20360	COG0018	arginyl-trna synthetase
K5X85_RS20365	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K5X85_RS20385	COG1690	Belongs to the RtcB family
K5X85_RS20395	COG1742	UPF0060 membrane protein
K5X85_RS20400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS20405	COG0431	NADPH-dependent FMN reductase
K5X85_RS20410	COG0745	RESPONSE REGULATOR receiver
K5X85_RS20470	COG1695	Transcriptional regulator
K5X85_RS20475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K5X85_RS20480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K5X85_RS20490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5X85_RS20495	COG0406	alpha-ribazole phosphatase activity
K5X85_RS20505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5X85_RS20510	COG0785	Cytochrome C biogenesis protein
K5X85_RS20515	COG1333	cytochrome c biogenesis protein
K5X85_RS20520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5X85_RS20530	COG0789	Transcriptional regulator
K5X85_RS20565	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K5X85_RS20570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K5X85_RS20575	COG0163	prenyltransferase activity
K5X85_RS20585	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K5X85_RS20590	COG1573	uracil-dna glycosylase
K5X85_RS20605	COG1301	dicarboxylic acid transport
K5X85_RS20615	COG1309	transcriptional regulator
K5X85_RS20620	COG1309	transcriptional regulator
K5X85_RS20635	COG0183	Belongs to the thiolase family
K5X85_RS20650	COG1278	Cold shock
K5X85_RS20655	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K5X85_RS20665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5X85_RS20665	COG0515	serine threonine protein kinase
K5X85_RS20670	COG1674	ftsk spoiiie
K5X85_RS20760	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K5X85_RS20845	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K5X85_RS20875	COG2226	methyltransferase
K5X85_RS20890	COG0242	peptide deformylase activity
K5X85_RS20895	COG3103	Sh3 type 3 domain protein
K5X85_RS20895	COG1388	LysM domain
K5X85_RS20895	COG0791	NLP P60 protein
K5X85_RS20905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5X85_RS20910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5X85_RS20915	COG0649	NAD binding
K5X85_RS20925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K5X85_RS20930	COG1034	ATP synthesis coupled electron transport
K5X85_RS20935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K5X85_RS20940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5X85_RS20950	COG0713	ATP synthesis coupled electron transport
K5X85_RS20955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K5X85_RS20965	COG1007	ATP synthesis coupled electron transport
K5X85_RS20975	COG0514	ATP-dependent DNA helicase (RecQ)
K5X85_RS20990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5X85_RS21030	COG0561	phosphatase activity
K5X85_RS21040	COG0142	geranyltranstransferase activity
K5X85_RS21090	COG0702	epimerase
K5X85_RS21095	COG1013	pyruvate-flavodoxin oxidoreductase activity
K5X85_RS21100	COG0674	pyruvate-flavodoxin oxidoreductase activity
K5X85_RS21100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K5X85_RS21120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5X85_RS21125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5X85_RS21130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5X85_RS21135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K5X85_RS21140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5X85_RS21150	COG0713	ATP synthesis coupled electron transport
K5X85_RS21155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K5X85_RS21165	COG1007	ATP synthesis coupled electron transport
K5X85_RS21170	COG0501	Belongs to the peptidase M48B family
K5X85_RS21175	COG3304	Inner membrane component domain
K5X85_RS21180	COG2261	transglycosylase associated protein
K5X85_RS21185	COG1666	GTP binding
K5X85_RS21200	COG0702	epimerase
K5X85_RS21205	COG0402	S-adenosylhomocysteine deaminase activity
K5X85_RS21220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5X85_RS21225	COG2030	dehydratase
K5X85_RS21240	COG0477	Major facilitator Superfamily
K5X85_RS21250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5X85_RS21255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5X85_RS21265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5X85_RS21270	COG0436	Aminotransferase
K5X85_RS21285	COG0250	Participates in transcription elongation, termination and antitermination
K5X85_RS21290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5X85_RS21295	COG0081	regulation of translation
K5X85_RS21310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5X85_RS21315	COG0222	ribosome binding
K5X85_RS21320	COG0085	RNA polymerase activity
K5X85_RS21325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5X85_RS21335	COG0463	Glycosyl transferase, family 2
K5X85_RS21340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5X85_RS21345	COG0049	tRNA binding
K5X85_RS21350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5X85_RS21355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5X85_RS21370	COG0577	efflux transmembrane transporter activity
K5X85_RS21375	COG1136	(ABC) transporter
K5X85_RS21380	COG4585	Histidine kinase
K5X85_RS21385	COG2197	response regulator
K5X85_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS21440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5X85_RS21445	COG1278	Cold shock
K5X85_RS21450	COG0513	Belongs to the DEAD box helicase family
K5X85_RS21490	COG0051	transcription antitermination factor activity, RNA binding
K5X85_RS21495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5X85_RS21500	COG0088	Forms part of the polypeptide exit tunnel
K5X85_RS21505	COG0089	rRNA binding
K5X85_RS21510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5X85_RS21515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5X85_RS21520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5X85_RS21525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5X85_RS21530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5X85_RS21535	COG0255	Belongs to the universal ribosomal protein uL29 family
K5X85_RS21540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5X85_RS21545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5X85_RS21550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5X85_RS21555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5X85_RS21560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5X85_RS21565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5X85_RS21570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5X85_RS21575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K5X85_RS21580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5X85_RS21585	COG1841	ribosomal large subunit assembly
K5X85_RS21590	COG0200	Binds to the 23S rRNA
K5X85_RS21595	COG0201	protein transport
K5X85_RS21600	COG0563	adenylate kinase activity
K5X85_RS21620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5X85_RS21625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5X85_RS21630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5X85_RS21635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5X85_RS21640	COG0202	RNA polymerase activity
K5X85_RS21645	COG0203	ribosomal protein L17
K5X85_RS21650	COG0101	tRNA pseudouridine synthase activity
K5X85_RS21665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5X85_RS21670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5X85_RS21675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5X85_RS21685	COG1072	(Pantothenic acid kinase))
K5X85_RS21695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5X85_RS21705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K5X85_RS21705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K5X85_RS21715	COG0736	holo-[acyl-carrier-protein] synthase activity
K5X85_RS21720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5X85_RS21730	COG0802	atpase or kinase
K5X85_RS21745	COG0456	acetyltransferase
K5X85_RS21745	COG1214	PFAM Peptidase M22, glycoprotease
K5X85_RS21755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5X85_RS21775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5X85_RS21775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K5X85_RS21785	COG1609	Transcriptional regulator
K5X85_RS21790	COG1316	TRANSCRIPTIONal
K5X85_RS21800	COG0726	polysaccharide deacetylase
K5X85_RS21805	COG0726	polysaccharide deacetylase
K5X85_RS21810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K5X85_RS21815	COG0459	protein refolding
K5X85_RS21820	COG1278	Cold shock
K5X85_RS21825	COG4221	oxidoreductase activity
K5X85_RS21835	COG0583	DNA-binding transcription factor activity
K5X85_RS21850	COG1595	DNA-templated transcription, initiation
K5X85_RS21860	COG0516	GMP reductase activity
K5X85_RS21870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5X85_RS21880	COG0515	serine threonine protein kinase
K5X85_RS21880	COG2815	serine threonine protein kinase
K5X85_RS21885	COG0515	serine threonine protein kinase
K5X85_RS21895	COG0515	serine threonine protein kinase
K5X85_RS21905	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS21925	COG0519	Catalyzes the synthesis of GMP from XMP
K5X85_RS21925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5X85_RS21960	COG2197	response regulator
K5X85_RS21965	COG0791	NLP P60 protein
K5X85_RS21990	COG0739	heme binding
K5X85_RS22000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS22000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS22015	COG0714	Associated with various cellular activities
K5X85_RS22020	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K5X85_RS22025	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K5X85_RS22040	COG0045	succinate-CoA ligase (ADP-forming) activity
K5X85_RS22070	COG0138	bifunctional purine biosynthesis protein purh
K5X85_RS22095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5X85_RS22110	COG0039	L-malate dehydrogenase activity
K5X85_RS22115	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS22125	COG0517	IMP dehydrogenase activity
K5X85_RS22125	COG4175	Glycine betaine
K5X85_RS22145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5X85_RS22150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5X85_RS22160	COG0754	glutathionylspermidine amidase activity
K5X85_RS22165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5X85_RS22170	COG0180	Tryptophanyl-tRNA synthetase
K5X85_RS22190	COG0671	phosphoesterase, PA-phosphatase related
K5X85_RS22205	COG1295	ribonuclease BN
K5X85_RS22210	COG1686	Belongs to the peptidase S11 family
K5X85_RS22220	COG1408	metallophosphoesterase
K5X85_RS22225	COG1309	transcriptional regulator
K5X85_RS22265	COG1053	succinate dehydrogenase
K5X85_RS22275	COG2009	succinate dehydrogenase
K5X85_RS22315	COG1595	DNA-templated transcription, initiation
K5X85_RS22330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS22330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS22360	COG1216	Glycosyl transferase, family 2
K5X85_RS22370	COG1216	Glycosyl transferase, family 2
K5X85_RS22385	COG2089	acid synthase
K5X85_RS22395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K5X85_RS22395	COG1473	amidohydrolase
K5X85_RS22400	COG1744	ABC transporter substrate-binding protein PnrA-like
K5X85_RS22405	COG1744	ABC transporter substrate-binding protein PnrA-like
K5X85_RS22410	COG3845	ABC transporter
K5X85_RS22415	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5X85_RS22420	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5X85_RS22455	COG2814	Major facilitator Superfamily
K5X85_RS22460	COG0583	DNA-binding transcription factor activity
K5X85_RS22470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5X85_RS22495	COG2205	protein histidine kinase activity
K5X85_RS22500	COG0745	RESPONSE REGULATOR receiver
K5X85_RS22505	COG1595	DNA-templated transcription, initiation
K5X85_RS22520	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS22525	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS22545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5X85_RS22570	COG4770	biotin carboxylase activity
K5X85_RS22580	COG0424	maF-like protein
K5X85_RS22590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5X85_RS22600	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K5X85_RS22610	COG1024	Enoyl-CoA hydratase
K5X85_RS22620	COG2986	histidine ammonia-lyase
K5X85_RS22645	COG1064	alcohol dehydrogenase
K5X85_RS22650	COG1090	epimerase
K5X85_RS22655	COG0667	Aldo Keto reductase
K5X85_RS22665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5X85_RS22690	COG2255	four-way junction helicase activity
K5X85_RS22695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K5X85_RS22710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5X85_RS22720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K5X85_RS22750	COG0590	tRNA wobble adenosine to inosine editing
K5X85_RS22755	COG1331	Highly conserved protein containing a thioredoxin domain
K5X85_RS22790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
K5X85_RS22825	COG0436	Aminotransferase
K5X85_RS22830	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K5X85_RS22845	COG1414	Transcriptional regulator
K5X85_RS22850	COG0251	oxidation-reduction process
K5X85_RS22855	COG2610	gluconate transmembrane transporter activity
K5X85_RS22910	COG2894	cell division
K5X85_RS22940	COG3920	Histidine kinase
K5X85_RS22945	COG2197	response regulator
K5X85_RS23015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K5X85_RS23030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5X85_RS23035	COG0450	alkyl hydroperoxide reductase
K5X85_RS23050	COG1136	(ABC) transporter
K5X85_RS23060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5X85_RS23075	COG0114	fumarate hydratase activity
K5X85_RS23080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K5X85_RS23080	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K5X85_RS23105	COG0778	Nitroreductase
K5X85_RS23115	COG1722	exodeoxyribonuclease VII activity
K5X85_RS23120	COG1570	exodeoxyribonuclease VII activity
K5X85_RS23130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K5X85_RS23145	COG0012	GTP binding
K5X85_RS23150	COG1201	RNA secondary structure unwinding
K5X85_RS23225	COG2318	DinB family
K5X85_RS23285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5X85_RS23290	COG1053	succinate dehydrogenase
K5X85_RS23310	COG1217	gtp-binding protein TYPA
K5X85_RS23315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS23320	COG4166	transmembrane transport
K5X85_RS23325	COG0601	transmembrane transport
K5X85_RS23330	COG0444	Belongs to the ABC transporter superfamily
K5X85_RS23335	COG4608	Belongs to the ABC transporter superfamily
K5X85_RS23340	COG4608	Belongs to the ABC transporter superfamily
K5X85_RS23345	COG0444	Belongs to the ABC transporter superfamily
K5X85_RS23350	COG0601	transmembrane transport
K5X85_RS23355	COG0747	negative chemotaxis
K5X85_RS23360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS23370	COG0601	transmembrane transport
K5X85_RS23375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS23380	COG0444	Belongs to the ABC transporter superfamily
K5X85_RS23385	COG4608	Belongs to the ABC transporter superfamily
K5X85_RS23400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K5X85_RS23420	COG0456	acetyltransferase
K5X85_RS23420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5X85_RS23445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X85_RS23455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K5X85_RS23465	COG0519	Catalyzes the synthesis of GMP from XMP
K5X85_RS23470	COG1024	Enoyl-CoA hydratase
K5X85_RS23485	COG1595	DNA-templated transcription, initiation
K5X85_RS23495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5X85_RS23500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5X85_RS23525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5X85_RS23535	COG0598	Magnesium transport protein CorA
K5X85_RS23545	COG2814	Major facilitator Superfamily
K5X85_RS23560	COG2095	MarC family integral membrane protein
K5X85_RS23570	COG1432	Conserved Protein
K5X85_RS23580	COG0513	Belongs to the DEAD box helicase family
K5X85_RS23645	COG0596	Alpha beta hydrolase
K5X85_RS23670	COG0210	DNA helicase
K5X85_RS23680	COG2816	NAD+ diphosphatase activity
K5X85_RS23710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5X85_RS23765	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5X85_RS23775	COG1615	UPF0182 protein
K5X85_RS23800	COG0753	catalase activity
K5X85_RS23810	COG0483	inositol monophosphate 1-phosphatase activity
K5X85_RS23825	COG1162	GTPase activity
K5X85_RS23830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K5X85_RS23840	COG2135	peptidase activity
K5X85_RS23850	COG1595	DNA-templated transcription, initiation
K5X85_RS23855	COG5662	AntiSigma factor
K5X85_RS23875	COG0242	peptide deformylase activity
K5X85_RS23885	COG2124	cytochrome p450
K5X85_RS23925	COG2188	Transcriptional regulator
K5X85_RS23930	COG2182	Extracellular solute-binding protein
K5X85_RS23935	COG1175	transmembrane transport
K5X85_RS23940	COG0395	ABC-type sugar transport system, permease component
K5X85_RS23945	COG1472	Belongs to the glycosyl hydrolase 3 family
K5X85_RS23950	COG0363	glucosamine-6-phosphate deaminase activity
K5X85_RS23955	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS23975	COG1597	lipid kinase activity
K5X85_RS24005	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K5X85_RS24015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5X85_RS24020	COG0142	geranyltranstransferase activity
K5X85_RS24045	COG4106	trans-aconitate 2-methyltransferase activity
K5X85_RS24050	COG1126	abc transporter atp-binding protein
K5X85_RS24065	COG0281	malic enzyme
K5X85_RS24070	COG0604	alcohol dehydrogenase
K5X85_RS24080	COG0542	response to heat
K5X85_RS24105	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5X85_RS24105	COG0567	Dehydrogenase, E1 component
K5X85_RS24110	COG2205	protein histidine kinase activity
K5X85_RS24115	COG0745	RESPONSE REGULATOR receiver
K5X85_RS24125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K5X85_RS24170	COG3883	PFAM NLP P60 protein
K5X85_RS24170	COG0791	NLP P60 protein
K5X85_RS24180	COG1309	transcriptional regulator
K5X85_RS24210	COG2205	protein histidine kinase activity
K5X85_RS24230	COG1793	dna ligase
K5X85_RS24230	COG3285	dna ligase
K5X85_RS24235	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K5X85_RS24255	COG3467	pyridoxamine 5'-phosphate
K5X85_RS24270	COG2867	negative regulation of translational initiation
K5X85_RS24275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5X85_RS24280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS24285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS24290	COG0662	Cupin 2, conserved barrel domain protein
K5X85_RS24295	COG2329	Antibiotic biosynthesis monooxygenase
K5X85_RS24300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS24355	COG2188	Transcriptional regulator
K5X85_RS24365	COG2188	Transcriptional regulator
K5X85_RS24435	COG0018	arginyl-trna synthetase
K5X85_RS24440	COG0019	diaminopimelate decarboxylase activity
K5X85_RS24445	COG0460	homoserine dehydrogenase
K5X85_RS24450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K5X85_RS24455	COG0083	homoserine kinase activity
K5X85_RS24470	COG1316	TRANSCRIPTIONal
K5X85_RS24475	COG0254	rRNA binding
K5X85_RS24480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5X85_RS24485	COG2890	protein-(glutamine-N5) methyltransferase activity
K5X85_RS24495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5X85_RS24500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5X85_RS24520	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5X85_RS24525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5X85_RS24530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5X85_RS24535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5X85_RS24540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5X85_RS24545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5X85_RS24550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5X85_RS24565	COG2197	response regulator
K5X85_RS24570	COG4585	Histidine kinase
K5X85_RS24600	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5X85_RS24615	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
K5X85_RS24650	COG1131	(ABC) transporter
K5X85_RS24670	COG0183	Belongs to the thiolase family
K5X85_RS24690	COG0745	RESPONSE REGULATOR receiver
K5X85_RS24695	COG2205	protein histidine kinase activity
K5X85_RS24740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS24740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS24775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5X85_RS24780	COG0280	phosphate acetyltransferase
K5X85_RS24780	COG0857	belongs to the CobB CobQ family
K5X85_RS24785	COG0205	6-phosphofructokinase activity
K5X85_RS24795	COG0395	ABC-type sugar transport system, permease component
K5X85_RS24805	COG1653	transport
K5X85_RS24810	COG4565	transcriptional regulatory protein
K5X85_RS24815	COG2205	protein histidine kinase activity
K5X85_RS24815	COG0745	RESPONSE REGULATOR receiver
K5X85_RS24815	COG4191	Histidine kinase
K5X85_RS24820	COG1301	dicarboxylic acid transport
K5X85_RS24830	COG3118	belongs to the thioredoxin family
K5X85_RS24830	COG0492	ferredoxin-NADP+ reductase activity
K5X85_RS24840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K5X85_RS24845	COG3281	Trehalose synthase
K5X85_RS24855	COG0366	Alpha amylase catalytic
K5X85_RS24860	COG0058	SHG alpha-glucan phosphorylase activity
K5X85_RS24875	COG1132	(ABC) transporter
K5X85_RS24880	COG1132	(ABC) transporter
K5X85_RS24885	COG1132	(ABC) transporter
K5X85_RS24890	COG1132	(ABC) transporter
K5X85_RS24895	COG3119	arylsulfatase activity
K5X85_RS24910	COG1376	ErfK ybiS ycfS ynhG family protein
K5X85_RS24940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5X85_RS24945	COG3757	hydrolase, family 25
K5X85_RS24945	COG3409	Peptidoglycan-binding domain 1 protein
K5X85_RS24950	COG0477	Major facilitator Superfamily
K5X85_RS24955	COG4977	sequence-specific DNA binding
K5X85_RS24980	COG1760	l-serine dehydratase
K5X85_RS24985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5X85_RS24990	COG0509	glycine decarboxylation via glycine cleavage system
K5X85_RS24995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5X85_RS25015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS25020	COG4166	transmembrane transport
K5X85_RS25030	COG0444	Belongs to the ABC transporter superfamily
K5X85_RS25035	COG4608	Belongs to the ABC transporter superfamily
K5X85_RS25040	COG2860	membrane
K5X85_RS25050	COG0789	Transcriptional regulator
K5X85_RS25060	COG1309	transcriptional regulator
K5X85_RS25085	COG0482	sulfurtransferase activity
K5X85_RS25100	COG1611	Belongs to the LOG family
K5X85_RS25115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5X85_RS25125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5X85_RS25130	COG0154	amidase activity
K5X85_RS25140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5X85_RS25145	COG2409	Drug exporters of the RND superfamily
K5X85_RS25150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5X85_RS25165	COG2197	response regulator
K5X85_RS25175	COG2133	pyrroloquinoline quinone binding
K5X85_RS25180	COG0667	Aldo Keto reductase
K5X85_RS25190	COG5001	Diguanylate cyclase
K5X85_RS25200	COG0440	acetolactate synthase activity
K5X85_RS25205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K5X85_RS25210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5X85_RS25220	COG0506	proline dehydrogenase activity
K5X85_RS25225	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS25230	COG0473	3-isopropylmalate dehydrogenase activity
K5X85_RS25235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5X85_RS25245	COG0832	Belongs to the urease beta subunit family
K5X85_RS25245	COG0831	urea catabolic process
K5X85_RS25250	COG0804	urea catabolic process
K5X85_RS25255	COG2957	Belongs to the agmatine deiminase family
K5X85_RS25265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5X85_RS25290	COG1335	isochorismatase
K5X85_RS25300	COG1032	radical SAM domain protein
K5X85_RS25305	COG5492	domain, Protein
K5X85_RS25310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5X85_RS25330	COG2018	Roadblock/LC7 domain
K5X85_RS25350	COG2018	Roadblock/LC7 domain
K5X85_RS25355	COG5002	protein histidine kinase activity
K5X85_RS25365	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5X85_RS25370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5X85_RS25375	COG1011	Hydrolase
K5X85_RS25410	COG1414	Transcriptional regulator
K5X85_RS25415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K5X85_RS25420	COG0066	3-isopropylmalate dehydratase activity
K5X85_RS25430	COG0776	regulation of translation
K5X85_RS25440	COG1920	GTP binding
K5X85_RS25450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5X85_RS25455	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5X85_RS25470	COG0351	phosphomethylpyrimidine kinase
K5X85_RS25475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5X85_RS25480	COG1461	Dihydroxyacetone kinase
K5X85_RS25490	COG0742	ribosomal rna small subunit methyltransferase
K5X85_RS25495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5X85_RS25510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5X85_RS25515	COG0571	ribonuclease III activity
K5X85_RS25520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5X85_RS25525	COG1733	regulation of RNA biosynthetic process
K5X85_RS25530	COG2340	Cysteine-rich secretory protein family
K5X85_RS25535	COG1254	Belongs to the acylphosphatase family
K5X85_RS25545	COG1196	nuclear chromosome segregation
K5X85_RS25550	COG0477	Major facilitator Superfamily
K5X85_RS25585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K5X85_RS25595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5X85_RS25615	COG0228	four-way junction DNA binding
K5X85_RS25620	COG1837	Belongs to the UPF0109 family
K5X85_RS25625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5X85_RS25630	COG0336	Belongs to the RNA methyltransferase TrmD family
K5X85_RS25635	COG0335	large ribosomal subunit rRNA binding
K5X85_RS25640	COG0681	Belongs to the peptidase S26 family
K5X85_RS25650	COG0681	Belongs to the peptidase S26 family
K5X85_RS25655	COG0681	Belongs to the peptidase S26 family
K5X85_RS25670	COG0792	nuclease activity
K5X85_RS25685	COG1191	sigma factor activity
K5X85_RS25700	COG0052	Belongs to the universal ribosomal protein uS2 family
K5X85_RS25705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5X85_RS25710	COG0528	UMP kinase activity
K5X85_RS25715	COG0233	cytoplasmic translational termination
K5X85_RS25720	COG0575	Belongs to the CDS family
K5X85_RS25725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5X85_RS25735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K5X85_RS25740	COG3842	ATPase activity
K5X85_RS25775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5X85_RS25785	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS25805	COG0584	glycerophosphoryl diester phosphodiesterase
K5X85_RS25810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5X85_RS25835	COG3842	ATPase activity
K5X85_RS25840	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5X85_RS25845	COG1177	transmembrane transport
K5X85_RS25850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS25890	COG2508	Transcriptional regulator
K5X85_RS25895	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS25905	COG2226	methyltransferase
K5X85_RS25910	COG1472	Belongs to the glycosyl hydrolase 3 family
K5X85_RS25920	COG4209	transmembrane transport
K5X85_RS25925	COG0395	ABC-type sugar transport system, permease component
K5X85_RS25960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K5X85_RS25965	COG0750	zinc metalloprotease
K5X85_RS25970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5X85_RS25985	COG0442	prolyl-tRNA aminoacylation
K5X85_RS26005	COG0779	Required for maturation of 30S ribosomal subunits
K5X85_RS26020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K5X85_RS26030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5X85_RS26035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5X85_RS26050	COG0455	bacterial-type flagellum organization
K5X85_RS26065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5X85_RS26070	COG1185	polyribonucleotide nucleotidyltransferase activity
K5X85_RS26075	COG0612	Peptidase, M16
K5X85_RS26080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5X85_RS26100	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K5X85_RS26105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5X85_RS26110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K5X85_RS26140	COG2208	phosphoserine phosphatase activity
K5X85_RS26140	COG2770	Histidine kinase
K5X85_RS26145	COG4999	Histidine kinase
K5X85_RS26145	COG3850	Histidine kinase
K5X85_RS26145	COG2205	protein histidine kinase activity
K5X85_RS26145	COG3437	response regulator, receiver
K5X85_RS26155	COG1674	ftsk spoiiie
K5X85_RS26165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5X85_RS26175	COG1058	Belongs to the CinA family
K5X85_RS26175	COG1546	Belongs to the CinA family
K5X85_RS26180	COG1396	sequence-specific DNA binding
K5X85_RS26185	COG0783	Belongs to the Dps family
K5X85_RS26205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5X85_RS26210	COG1201	RNA secondary structure unwinding
K5X85_RS26215	COG1917	Cupin 2, conserved barrel domain protein
K5X85_RS26215	COG2207	Transcriptional regulator
K5X85_RS26240	COG0628	permease
K5X85_RS26260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5X85_RS26275	COG0765	amino acid transport
K5X85_RS26280	COG0765	amino acid transport
K5X85_RS26285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5X85_RS26290	COG1126	abc transporter atp-binding protein
K5X85_RS26295	COG0745	RESPONSE REGULATOR receiver
K5X85_RS26300	COG2205	protein histidine kinase activity
K5X85_RS26335	COG2197	response regulator
K5X85_RS26340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5X85_RS26360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5X85_RS26370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K5X85_RS26375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5X85_RS26385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5X85_RS26420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5X85_RS26425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5X85_RS26430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5X85_RS26445	COG0588	phosphoglycerate mutase activity
K5X85_RS26465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5X85_RS26505	COG2186	Transcriptional regulator
K5X85_RS26510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5X85_RS26525	COG0187	DNA topoisomerase II activity
K5X85_RS26535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5X85_RS26540	COG4565	transcriptional regulatory protein
K5X85_RS26545	COG3290	protein histidine kinase activity
K5X85_RS26570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5X85_RS26575	COG0612	Peptidase, M16
K5X85_RS26590	COG1802	Transcriptional regulator
K5X85_RS26595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5X85_RS26615	COG1435	thymidine kinase activity
K5X85_RS26650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5X85_RS26665	COG0745	RESPONSE REGULATOR receiver
K5X85_RS26670	COG2205	protein histidine kinase activity
K5X85_RS26695	COG0756	dUTP diphosphatase activity
K5X85_RS26705	COG1136	(ABC) transporter
K5X85_RS26705	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5X85_RS26735	COG0569	domain protein
K5X85_RS26740	COG0531	amino acid
K5X85_RS26745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5X85_RS26760	COG3693	PFAM glycoside hydrolase, family 10
K5X85_RS26790	COG0456	acetyltransferase
K5X85_RS26800	COG0531	amino acid
K5X85_RS26810	COG0477	Major facilitator Superfamily
K5X85_RS26815	COG1122	ATPase activity
K5X85_RS26825	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
K5X85_RS26830	COG0310	cobalt ion transport
K5X85_RS26835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5X85_RS26850	COG1799	cell septum assembly
K5X85_RS26855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5X85_RS26885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5X85_RS26895	COG2255	four-way junction helicase activity
K5X85_RS26905	COG0475	glutathione-regulated potassium exporter activity
K5X85_RS26930	COG2235	arginine
K5X85_RS26935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5X85_RS26940	COG0531	amino acid
K5X85_RS26950	COG1024	Enoyl-CoA hydratase
K5X85_RS27040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5X85_RS27050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K5X85_RS27065	COG1653	transport
K5X85_RS27070	COG1175	transmembrane transport
K5X85_RS27075	COG0395	ABC-type sugar transport system, permease component
K5X85_RS27080	COG1940	carbohydrate kinase activity
K5X85_RS27085	COG4213	ABC transporter substrate-binding protein
K5X85_RS27095	COG4214	carbohydrate transport
K5X85_RS27100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5X85_RS27105	COG0531	amino acid
K5X85_RS27140	COG1215	transferase activity, transferring glycosyl groups
K5X85_RS27140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5X85_RS27145	COG2755	lipolytic protein G-D-S-L family
K5X85_RS27165	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5X85_RS27165	COG1024	Enoyl-CoA hydratase
K5X85_RS27170	COG0183	Belongs to the thiolase family
K5X85_RS27175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K5X85_RS27190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K5X85_RS27205	COG4555	ABC transporter
K5X85_RS27220	COG0076	glutamate decarboxylase activity
K5X85_RS27245	COG1472	Belongs to the glycosyl hydrolase 3 family
K5X85_RS27260	COG0019	diaminopimelate decarboxylase activity
K5X85_RS27285	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5X85_RS27295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K5X85_RS27300	COG3253	May function as heme-dependent peroxidase
K5X85_RS27315	COG3220	belongs to the UPF0276 family
K5X85_RS27340	COG0723	plastoquinol--plastocyanin reductase activity
K5X85_RS27340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS27350	COG0330	HflC and HflK could
K5X85_RS27385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5X85_RS27390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5X85_RS27400	COG0745	RESPONSE REGULATOR receiver
K5X85_RS27410	COG1174	glycine betaine transport
K5X85_RS27415	COG1174	glycine betaine transport
K5X85_RS27420	COG1732	Glycine betaine
K5X85_RS27470	COG1309	transcriptional regulator
K5X85_RS27485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5X85_RS27570	COG2409	Drug exporters of the RND superfamily
K5X85_RS27590	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K5X85_RS27610	COG0529	Catalyzes the synthesis of activated sulfate
K5X85_RS27615	COG0175	sulfate reduction
K5X85_RS27645	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS27660	COG4977	sequence-specific DNA binding
K5X85_RS27660	COG1917	Cupin 2, conserved barrel domain protein
K5X85_RS27680	COG0326	Molecular chaperone. Has ATPase activity
K5X85_RS27700	COG1131	(ABC) transporter
K5X85_RS27740	COG0714	Associated with various cellular activities
K5X85_RS27755	COG2040	homocysteine
K5X85_RS27770	COG2197	response regulator
K5X85_RS27780	COG2755	lipolytic protein G-D-S-L family
K5X85_RS27795	COG1309	transcriptional regulator
K5X85_RS27815	COG0277	FAD linked oxidase domain protein
K5X85_RS27830	COG0542	response to heat
K5X85_RS27895	COG1162	GTPase activity
K5X85_RS27905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5X85_RS27925	COG0028	Belongs to the TPP enzyme family
K5X85_RS27945	COG1802	Transcriptional regulator
K5X85_RS27950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5X85_RS27960	COG2197	response regulator
K5X85_RS27965	COG3851	Histidine kinase
K5X85_RS28000	COG3835	regulator
K5X85_RS28005	COG2252	PERMEase
K5X85_RS28025	COG0726	polysaccharide deacetylase
K5X85_RS28035	COG2192	nodulation
K5X85_RS28045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5X85_RS28050	COG0859	PFAM glycosyl transferase family 9
K5X85_RS28055	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS28060	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS28065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K5X85_RS28070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5X85_RS28070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K5X85_RS28110	COG2197	response regulator
K5X85_RS28115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5X85_RS28120	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS28130	COG3960	tartronate-semialdehyde synthase activity
K5X85_RS28145	COG0753	catalase activity
K5X85_RS28150	COG2084	Dehydrogenase
K5X85_RS28155	COG3622	Belongs to the hyi family
K5X85_RS28175	COG2351	hydroxyisourate hydrolase activity
K5X85_RS28185	COG2233	PERMEase
K5X85_RS28195	COG2233	PERMEase
K5X85_RS28210	COG0406	alpha-ribazole phosphatase activity
K5X85_RS28235	COG4264	IucA IucC family
K5X85_RS28250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K5X85_RS28265	COG1414	Transcriptional regulator
K5X85_RS28270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5X85_RS28275	COG4266	Belongs to the allantoicase family
K5X85_RS28280	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS28300	COG2197	response regulator
K5X85_RS28305	COG0673	inositol 2-dehydrogenase activity
K5X85_RS28310	COG2188	Transcriptional regulator
K5X85_RS28330	COG1940	carbohydrate kinase activity
K5X85_RS28340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5X85_RS28355	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5X85_RS28360	COG3246	L-lysine catabolic process to acetate
K5X85_RS28380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS28390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5X85_RS28405	COG2175	clavaminate synthase activity
K5X85_RS28410	COG1132	(ABC) transporter
K5X85_RS28415	COG0510	thiamine kinase activity
K5X85_RS28425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K5X85_RS28455	COG2197	response regulator
K5X85_RS28460	COG4585	Histidine kinase
K5X85_RS28500	COG3903	Transcriptional regulator
K5X85_RS28500	COG3629	intracellular signal transduction
K5X85_RS28505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5X85_RS28510	COG4122	O-methyltransferase activity
K5X85_RS28515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5X85_RS28520	COG0512	Glutamine amidotransferase of anthranilate synthase
K5X85_RS28520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5X85_RS28525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5X85_RS28530	COG0134	indole-3-glycerol-phosphate synthase activity
K5X85_RS28535	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K5X85_RS28580	COG1301	dicarboxylic acid transport
K5X85_RS28585	COG4948	Mandelate Racemase Muconate Lactonizing
K5X85_RS28600	COG1621	beta-fructofuranosidase activity
K5X85_RS28605	COG1609	Transcriptional regulator
K5X85_RS28615	COG1175	transmembrane transport
K5X85_RS28620	COG0395	ABC-type sugar transport system, permease component
K5X85_RS28625	COG1621	beta-fructofuranosidase activity
K5X85_RS28635	COG0778	Nitroreductase
K5X85_RS28640	COG0477	Major facilitator Superfamily
K5X85_RS28645	COG1309	transcriptional regulator
K5X85_RS28650	COG2084	Dehydrogenase
K5X85_RS28660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5X85_RS28665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS28675	COG2814	Major facilitator Superfamily
K5X85_RS28680	COG1414	Transcriptional regulator
K5X85_RS28685	COG1846	Transcriptional regulator
K5X85_RS28690	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5X85_RS28700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS28725	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5X85_RS28730	COG1234	tRNA 3'-trailer cleavage
K5X85_RS28745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS28765	COG1609	Transcriptional regulator
K5X85_RS28775	COG2182	Extracellular solute-binding protein
K5X85_RS28785	COG0395	ABC-type sugar transport system, permease component
K5X85_RS28790	COG3250	beta-galactosidase activity
K5X85_RS28820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5X85_RS28825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5X85_RS28845	COG0405	Gamma-glutamyltransferase
K5X85_RS28850	COG0542	response to heat
K5X85_RS28870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5X85_RS28885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5X85_RS28895	COG1953	Uracil, thiamine, allantoin
K5X85_RS28915	COG3851	Histidine kinase
K5X85_RS28920	COG2197	response regulator
K5X85_RS28925	COG0095	Lipoate-protein ligase
K5X85_RS28945	COG0483	inositol monophosphate 1-phosphatase activity
K5X85_RS28950	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5X85_RS28965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K5X85_RS28980	COG0601	transmembrane transport
K5X85_RS28985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS28990	COG0444	Belongs to the ABC transporter superfamily
K5X85_RS29000	COG3540	Alkaline phosphatase
K5X85_RS29015	COG0640	Transcriptional regulator
K5X85_RS29035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5X85_RS29045	COG1929	Belongs to the glycerate kinase type-1 family
K5X85_RS29055	COG0688	phosphatidylethanolamine metabolic process
K5X85_RS29060	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS29070	COG2301	Belongs to the HpcH HpaI aldolase family
K5X85_RS29075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS29075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K5X85_RS29080	COG0604	alcohol dehydrogenase
K5X85_RS29090	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5X85_RS29105	COG0596	Alpha beta hydrolase
K5X85_RS29140	COG3293	Transposase
K5X85_RS29405	COG2208	phosphoserine phosphatase activity
K5X85_RS29405	COG2172	sigma factor antagonist activity
K5X85_RS29405	COG1366	Belongs to the anti-sigma-factor antagonist family
K5X85_RS29410	COG2226	methyltransferase
K5X85_RS29415	COG2362	D-Aminopeptidase
K5X85_RS29420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X85_RS29425	COG0823	Involved in the tonB-independent uptake of proteins
K5X85_RS29425	COG1506	peptidase
K5X85_RS29425	COG4946	Tricorn protease homolog
K5X85_RS29430	COG1619	proteins homologs of microcin C7 resistance protein MccF
K5X85_RS29460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS29475	COG1793	dna ligase
K5X85_RS29475	COG3285	dna ligase
K5X85_RS29540	COG1597	lipid kinase activity
K5X85_RS29545	COG0488	(ABC) transporter
K5X85_RS29560	COG0693	protein deglycase activity
K5X85_RS29575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5X85_RS29630	COG0531	amino acid
K5X85_RS29660	COG1140	nitrate reductase beta subunit
K5X85_RS29690	COG2154	pterin-4-alpha-carbinolamine dehydratase
K5X85_RS29695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K5X85_RS29695	COG4106	trans-aconitate 2-methyltransferase activity
K5X85_RS29700	COG3401	FG-GAP repeat protein
K5X85_RS29715	COG5297	Belongs to the glycosyl hydrolase family 6
K5X85_RS29715	COG4733	cellulase activity
K5X85_RS29720	COG5297	Belongs to the glycosyl hydrolase family 6
K5X85_RS29730	COG0656	L-ascorbic acid biosynthetic process
K5X85_RS29755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K5X85_RS29765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K5X85_RS29770	COG3383	formate dehydrogenase (NAD+) activity
K5X85_RS29775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5X85_RS29790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5X85_RS29805	COG1129	ABC transporter
K5X85_RS29810	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5X85_RS29820	COG0673	inositol 2-dehydrogenase activity
K5X85_RS29840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K5X85_RS29875	COG2223	nitrite transmembrane transporter activity
K5X85_RS29885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K5X85_RS29895	COG0045	succinate-CoA ligase (ADP-forming) activity
K5X85_RS29905	COG1012	belongs to the aldehyde dehydrogenase family
K5X85_RS29920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5X85_RS29940	COG0714	Associated with various cellular activities
K5X85_RS29945	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K5X85_RS29980	COG0210	DNA helicase
K5X85_RS29995	COG0747	negative chemotaxis
K5X85_RS30000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS30025	COG0297	glycogen (starch) synthase activity
K5X85_RS30045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5X85_RS30065	COG0477	Major facilitator Superfamily
K5X85_RS30075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5X85_RS30080	COG1082	Xylose isomerase domain protein TIM barrel
K5X85_RS30080	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K5X85_RS30090	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5X85_RS30095	COG0166	Belongs to the GPI family
K5X85_RS30110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K5X85_RS30140	COG1486	melibiose metabolic process
K5X85_RS30150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K5X85_RS30180	COG0477	Major facilitator Superfamily
K5X85_RS30185	COG3511	phospholipase C
K5X85_RS30215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5X85_RS30220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5X85_RS30225	COG3485	protocatechuate 3,4-dioxygenase
K5X85_RS30230	COG3485	protocatechuate 3,4-dioxygenase
K5X85_RS30235	COG0183	Belongs to the thiolase family
K5X85_RS30255	COG1470	cell adhesion involved in biofilm formation
K5X85_RS30265	COG1793	dna ligase
K5X85_RS30270	COG0488	(ABC) transporter
K5X85_RS30310	COG1834	amidinotransferase
K5X85_RS30315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5X85_RS30320	COG0488	(ABC) transporter
K5X85_RS30345	COG1515	deoxyribonuclease V activity
K5X85_RS30360	COG3268	Saccharopine dehydrogenase
K5X85_RS30365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K5X85_RS30370	COG0183	Belongs to the thiolase family
K5X85_RS30375	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5X85_RS30375	COG1024	Enoyl-CoA hydratase
K5X85_RS30385	COG1113	amino acid transport
K5X85_RS30400	COG2936	dipeptidyl-peptidase activity
K5X85_RS30410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5X85_RS30425	COG0488	(ABC) transporter
K5X85_RS30450	COG1024	Enoyl-CoA hydratase
K5X85_RS30460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K5X85_RS30500	COG1134	teichoic acid transport
K5X85_RS30505	COG1562	ergosterol biosynthetic process
K5X85_RS30520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K5X85_RS30530	COG1657	PFAM Prenyltransferase squalene oxidase
K5X85_RS30545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5X85_RS30550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5X85_RS30570	COG2365	Tyrosine phosphatase family
K5X85_RS30580	COG2755	lipolytic protein G-D-S-L family
K5X85_RS30625	COG1063	alcohol dehydrogenase
K5X85_RS30630	COG0156	8-amino-7-oxononanoate synthase activity
K5X85_RS30635	COG0583	DNA-binding transcription factor activity
K5X85_RS30665	COG2111	Na H antiporter
K5X85_RS30665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K5X85_RS30670	COG1006	Multisubunit Na H antiporter MnhC subunit
K5X85_RS30675	COG0651	ATP synthesis coupled electron transport
K5X85_RS30690	COG1320	monovalent cation:proton antiporter activity
K5X85_RS30705	COG0174	glutamine synthetase
K5X85_RS30725	COG2267	carboxylic ester hydrolase activity
K5X85_RS30730	COG0183	Belongs to the thiolase family
K5X85_RS30735	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS30775	COG0494	nUDIX hydrolase
K5X85_RS30780	COG2188	Transcriptional regulator
K5X85_RS30785	COG3962	Belongs to the TPP enzyme family
K5X85_RS30790	COG3718	enzyme involved in inositol metabolism
K5X85_RS30800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5X85_RS30825	COG2764	glyoxalase bleomycin resistance protein dioxygenase
K5X85_RS30830	COG0673	inositol 2-dehydrogenase activity
K5X85_RS30835	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS30845	COG1609	Transcriptional regulator
K5X85_RS30850	COG3548	integral membrane protein
K5X85_RS30855	COG0673	inositol 2-dehydrogenase activity
K5X85_RS30865	COG0385	Bile acid
K5X85_RS30880	COG2197	response regulator
K5X85_RS30905	COG2124	cytochrome p450
K5X85_RS30915	COG2838	Isocitrate dehydrogenase
K5X85_RS30920	COG0668	transmembrane transport
K5X85_RS30930	COG1132	(ABC) transporter
K5X85_RS30940	COG0366	Alpha amylase catalytic
K5X85_RS30945	COG0395	ABC-type sugar transport system, permease component
K5X85_RS30950	COG1175	transmembrane transport
K5X85_RS30955	COG1653	transport
K5X85_RS30980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5X85_RS31000	COG3938	Belongs to the proline racemase family
K5X85_RS31005	COG1802	Transcriptional regulator
K5X85_RS31010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS31015	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K5X85_RS31025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5X85_RS31030	COG4106	trans-aconitate 2-methyltransferase activity
K5X85_RS31040	COG2267	carboxylic ester hydrolase activity
K5X85_RS31045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5X85_RS31055	COG0019	diaminopimelate decarboxylase activity
K5X85_RS31065	COG4865	methylaspartate mutase activity
K5X85_RS31075	COG0477	Major facilitator Superfamily
K5X85_RS31105	COG0667	Aldo Keto reductase
K5X85_RS31120	COG3321	synthase
K5X85_RS31120	COG0604	alcohol dehydrogenase
K5X85_RS31130	COG3321	synthase
K5X85_RS31130	COG0604	alcohol dehydrogenase
K5X85_RS31135	COG0604	alcohol dehydrogenase
K5X85_RS31135	COG3321	synthase
K5X85_RS31150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K5X85_RS31165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5X85_RS31185	COG0297	glycogen (starch) synthase activity
K5X85_RS31190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5X85_RS31230	COG1609	Transcriptional regulator
K5X85_RS31235	COG1653	transport
K5X85_RS31240	COG1175	transmembrane transport
K5X85_RS31245	COG0395	ABC-type sugar transport system, permease component
K5X85_RS31275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5X85_RS31310	COG0531	amino acid
K5X85_RS31320	COG0726	polysaccharide deacetylase
K5X85_RS31360	COG0583	DNA-binding transcription factor activity
K5X85_RS31370	COG1053	succinate dehydrogenase
K5X85_RS31375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5X85_RS31400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS31410	COG3360	Dodecin
K5X85_RS31420	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K5X85_RS31425	COG0121	glutamine amidotransferase
K5X85_RS31430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5X85_RS31435	COG3572	ergothioneine biosynthetic process
K5X85_RS31450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5X85_RS31475	COG0596	Alpha beta hydrolase
K5X85_RS31480	COG3903	Transcriptional regulator
K5X85_RS31480	COG3629	intracellular signal transduction
K5X85_RS31500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5X85_RS31505	COG1053	succinate dehydrogenase
K5X85_RS31505	COG3976	FMN-binding domain protein
K5X85_RS31525	COG0583	DNA-binding transcription factor activity
K5X85_RS31540	COG1609	Transcriptional regulator
K5X85_RS31545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5X85_RS31555	COG0242	peptide deformylase activity
K5X85_RS31570	COG1683	Conserved Protein
K5X85_RS31610	COG1846	Transcriptional regulator
K5X85_RS31615	COG2409	Drug exporters of the RND superfamily
K5X85_RS31630	COG0668	transmembrane transport
K5X85_RS31670	COG3540	Alkaline phosphatase
K5X85_RS31695	COG0577	efflux transmembrane transporter activity
K5X85_RS31695	COG1136	(ABC) transporter
K5X85_RS31700	COG1556	Lactate utilization protein
K5X85_RS31705	COG1139	Iron-sulfur cluster binding protein
K5X85_RS31710	COG0247	lactate metabolic process
K5X85_RS31715	COG1070	Carbohydrate kinase
K5X85_RS31720	COG3347	Dehydrogenase
K5X85_RS31720	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS31725	COG4952	isomerase
K5X85_RS31730	COG1129	ABC transporter
K5X85_RS31735	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5X85_RS31740	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5X85_RS31755	COG1609	Transcriptional regulator
K5X85_RS31770	COG1357	PFAM Pentapeptide repeats (8 copies)
K5X85_RS31780	COG1309	transcriptional regulator
K5X85_RS31820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K5X85_RS31820	COG1796	DNA polymerase
K5X85_RS31825	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS31855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5X85_RS31915	COG0435	Glutathione S-transferase
K5X85_RS31935	COG0667	Aldo Keto reductase
K5X85_RS31970	COG1304	FMN binding
K5X85_RS31985	COG2890	protein-(glutamine-N5) methyltransferase activity
K5X85_RS32000	COG0248	Ppx GppA phosphatase
K5X85_RS32080	COG1132	(ABC) transporter
K5X85_RS32110	COG2182	Extracellular solute-binding protein
K5X85_RS32115	COG0395	ABC-type sugar transport system, permease component
K5X85_RS32120	COG1175	transmembrane transport
K5X85_RS32125	COG1846	Transcriptional regulator
K5X85_RS32125	COG1940	carbohydrate kinase activity
K5X85_RS32155	COG1309	transcriptional regulator
K5X85_RS32185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5X85_RS32235	COG0673	inositol 2-dehydrogenase activity
K5X85_RS32250	COG2508	Transcriptional regulator
K5X85_RS32255	COG0410	ABC transporter
K5X85_RS32260	COG0411	ABC transporter
K5X85_RS32305	COG1132	(ABC) transporter
K5X85_RS32350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K5X85_RS32355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K5X85_RS32360	COG2080	2 iron, 2 sulfur cluster binding
K5X85_RS32370	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS32375	COG1295	ribonuclease BN
K5X85_RS32405	COG0477	Major facilitator Superfamily
K5X85_RS32420	COG3290	protein histidine kinase activity
K5X85_RS32460	COG0277	FAD linked oxidase domain protein
K5X85_RS32465	COG1597	lipid kinase activity
K5X85_RS32490	COG0395	ABC-type sugar transport system, permease component
K5X85_RS32495	COG1175	transmembrane transport
K5X85_RS32505	COG1609	Transcriptional regulator
K5X85_RS32560	COG2264	protein methyltransferase activity
K5X85_RS32565	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS32595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS32605	COG4608	Belongs to the ABC transporter superfamily
K5X85_RS32625	COG3397	chitin binding
K5X85_RS32675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5X85_RS32680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5X85_RS32695	COG1595	DNA-templated transcription, initiation
K5X85_RS32715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5X85_RS32720	COG1937	Protein conserved in bacteria
K5X85_RS32725	COG0730	response to heat
K5X85_RS32735	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
K5X85_RS32765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5X85_RS32775	COG2235	arginine
K5X85_RS32830	COG0505	Belongs to the CarA family
K5X85_RS32860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K5X85_RS32865	COG1191	sigma factor activity
K5X85_RS32885	COG0783	Belongs to the Dps family
K5X85_RS32890	COG0655	NAD(P)H dehydrogenase (quinone) activity
K5X85_RS32930	COG4232	protein-disulfide reductase activity
K5X85_RS32935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5X85_RS32935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5X85_RS32955	COG2018	Roadblock/LC7 domain
K5X85_RS32970	COG2124	cytochrome p450
K5X85_RS32975	COG2124	cytochrome p450
K5X85_RS32985	COG2186	Transcriptional regulator
K5X85_RS32995	COG2376	Dihydroxyacetone kinase
K5X85_RS33000	COG0698	ribose 5-phosphate isomerase
K5X85_RS33005	COG0149	triose-phosphate isomerase activity
K5X85_RS33010	COG1082	Xylose isomerase domain protein TIM barrel
K5X85_RS33015	COG2084	Dehydrogenase
K5X85_RS33020	COG3340	Belongs to the peptidase S51 family
K5X85_RS33035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K5X85_RS33040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5X85_RS33045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5X85_RS33050	COG0142	geranyltranstransferase activity
K5X85_RS33060	COG0142	geranyltranstransferase activity
K5X85_RS33100	COG0789	Transcriptional regulator
K5X85_RS33140	COG0745	RESPONSE REGULATOR receiver
K5X85_RS33145	COG2205	protein histidine kinase activity
K5X85_RS33150	COG2340	Cysteine-rich secretory protein family
K5X85_RS33155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5X85_RS33160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS33175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K5X85_RS33200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5X85_RS33205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5X85_RS33215	COG0438	transferase activity, transferring glycosyl groups
K5X85_RS33235	COG0667	Aldo Keto reductase
K5X85_RS33250	COG1196	nuclear chromosome segregation
K5X85_RS33250	COG0741	lytic transglycosylase activity
K5X85_RS33250	COG0739	heme binding
K5X85_RS33260	COG1309	transcriptional regulator
K5X85_RS33265	COG0318	PFAM AMP-dependent synthetase and ligase
K5X85_RS33270	COG1960	acyl-CoA dehydrogenase activity
K5X85_RS33275	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K5X85_RS33295	COG0673	inositol 2-dehydrogenase activity
K5X85_RS33305	COG1278	Cold shock
K5X85_RS33320	COG3386	PFAM SMP-30 Gluconolaconase
K5X85_RS33335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5X85_RS33345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5X85_RS33375	COG3486	L-lysine 6-monooxygenase (NADPH) activity
K5X85_RS33380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS33385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS33390	COG1120	ATPase activity
K5X85_RS33395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K5X85_RS33400	COG1132	(ABC) transporter
K5X85_RS33410	COG1132	(ABC) transporter
K5X85_RS33415	COG2382	esterase
K5X85_RS33440	COG4106	trans-aconitate 2-methyltransferase activity
K5X85_RS33450	COG0477	Major facilitator Superfamily
K5X85_RS33465	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K5X85_RS33480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5X85_RS33495	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS33500	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS33515	COG0028	Belongs to the TPP enzyme family
K5X85_RS33520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K5X85_RS33535	COG0604	alcohol dehydrogenase
K5X85_RS33535	COG3321	synthase
K5X85_RS33555	COG2124	cytochrome p450
K5X85_RS33560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5X85_RS33565	COG0604	alcohol dehydrogenase
K5X85_RS33575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS33660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K5X85_RS33670	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS33675	COG0667	Aldo Keto reductase
K5X85_RS33680	COG0366	Alpha amylase catalytic
K5X85_RS33680	COG1470	cell adhesion involved in biofilm formation
K5X85_RS33685	COG1609	Transcriptional regulator
K5X85_RS33710	COG2375	cellular response to nickel ion
K5X85_RS33735	COG1984	allophanate hydrolase subunit 2
K5X85_RS33740	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K5X85_RS33745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K5X85_RS33760	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K5X85_RS33770	COG0667	Aldo Keto reductase
K5X85_RS33775	COG2770	Histidine kinase
K5X85_RS33775	COG2208	phosphoserine phosphatase activity
K5X85_RS33795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5X85_RS33800	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
K5X85_RS33810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS33820	COG2814	Major facilitator Superfamily
K5X85_RS33825	COG0384	phenazine biosynthesis protein PhzF
K5X85_RS33830	COG1609	Transcriptional regulator
K5X85_RS33840	COG0402	S-adenosylhomocysteine deaminase activity
K5X85_RS33865	COG4221	oxidoreductase activity
K5X85_RS33895	COG1595	DNA-templated transcription, initiation
K5X85_RS33925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS33930	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K5X85_RS33960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5X85_RS33970	COG0302	gtp cyclohydrolase
K5X85_RS33985	COG0667	Aldo Keto reductase
K5X85_RS34005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5X85_RS34010	COG0739	heme binding
K5X85_RS34030	COG0583	DNA-binding transcription factor activity
K5X85_RS34055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS34060	COG0747	negative chemotaxis
K5X85_RS34075	COG0747	negative chemotaxis
K5X85_RS34085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5X85_RS34090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5X85_RS34095	COG1021	2,3-dihydroxybenzoate-AMP ligase
K5X85_RS34100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K5X85_RS34100	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
K5X85_RS34105	COG2226	methyltransferase
K5X85_RS34105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K5X85_RS34105	COG3433	isochorismatase activity
K5X85_RS34125	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
K5X85_RS34135	COG1132	(ABC) transporter
K5X85_RS34135	COG2375	cellular response to nickel ion
K5X85_RS34140	COG1132	(ABC) transporter
K5X85_RS34145	COG1169	isochorismate synthase
K5X85_RS34155	COG0523	cobalamin synthesis protein
K5X85_RS34165	COG0778	Nitroreductase
K5X85_RS34230	COG1252	NADH dehydrogenase
K5X85_RS34235	COG1595	DNA-templated transcription, initiation
K5X85_RS34285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5X85_RS34300	COG2723	6-phospho-beta-galactosidase activity
K5X85_RS34305	COG3833	ABC-type maltose transport systems, permease component
K5X85_RS34310	COG1175	transmembrane transport
K5X85_RS34315	COG2182	Extracellular solute-binding protein
K5X85_RS34370	COG2197	response regulator
K5X85_RS34375	COG1132	(ABC) transporter
K5X85_RS34380	COG1132	(ABC) transporter
K5X85_RS34390	COG0515	serine threonine protein kinase
K5X85_RS34435	COG3226	Transcriptional regulator
K5X85_RS34440	COG0738	Major facilitator superfamily
K5X85_RS34455	COG4221	oxidoreductase activity
K5X85_RS34460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5X85_RS34490	COG0583	DNA-binding transcription factor activity
K5X85_RS34495	COG1136	(ABC) transporter
K5X85_RS34540	COG2814	Major facilitator Superfamily
K5X85_RS34545	COG4585	Histidine kinase
K5X85_RS34550	COG2197	response regulator
K5X85_RS34560	COG0745	RESPONSE REGULATOR receiver
K5X85_RS34565	COG5002	protein histidine kinase activity
K5X85_RS34580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K5X85_RS34600	COG1309	transcriptional regulator
K5X85_RS34610	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS34655	COG2223	nitrite transmembrane transporter activity
K5X85_RS34670	COG2205	protein histidine kinase activity
K5X85_RS34675	COG0745	RESPONSE REGULATOR receiver
K5X85_RS34685	COG1131	(ABC) transporter
K5X85_RS34700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS34705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5X85_RS34710	COG1120	ATPase activity
K5X85_RS34715	COG1132	(ABC) transporter
K5X85_RS34720	COG1132	(ABC) transporter
K5X85_RS34780	COG3293	Transposase
K5X85_RS34800	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5X85_RS34830	COG0583	DNA-binding transcription factor activity
K5X85_RS34850	COG1959	2 iron, 2 sulfur cluster binding
K5X85_RS34870	COG2197	response regulator
K5X85_RS34875	COG4585	Histidine kinase
K5X85_RS34885	COG1136	(ABC) transporter
K5X85_RS34900	COG0477	Major facilitator Superfamily
K5X85_RS34910	COG1609	Transcriptional regulator
K5X85_RS34930	COG4585	Histidine kinase
K5X85_RS34935	COG2197	response regulator
K5X85_RS34945	COG1132	(ABC) transporter
K5X85_RS34975	COG3250	beta-galactosidase activity
K5X85_RS34980	COG0395	ABC-type sugar transport system, permease component
K5X85_RS34985	COG1175	transmembrane transport
K5X85_RS34995	COG1609	Transcriptional regulator
K5X85_RS35000	COG1028	Short-chain dehydrogenase reductase Sdr
K5X85_RS35005	COG1802	Transcriptional regulator
K5X85_RS35010	COG4948	Mandelate Racemase Muconate Lactonizing
K5X85_RS35040	COG1309	transcriptional regulator
K5X85_RS35055	COG1309	transcriptional regulator
K5X85_RS35060	COG0300	oxidoreductase activity
K5X85_RS35080	COG0583	DNA-binding transcription factor activity
K5X85_RS35090	COG0604	alcohol dehydrogenase
K5X85_RS35185	COG2226	methyltransferase
K5X85_RS35205	COG1063	alcohol dehydrogenase
K5X85_RS35310	COG0702	epimerase
K5X85_RS35325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5X85_RS35355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5X85_RS35590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5X85_RS35655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5X85_RS35665	COG2197	response regulator
K5X85_RS35675	COG2409	Drug exporters of the RND superfamily
K5X85_RS35690	COG4974	Belongs to the 'phage' integrase family
K5X85_RS35740	COG1192	Involved in chromosome partitioning
K5X85_RS35760	COG0592	DNA-directed DNA polymerase activity
K5X85_RS35830	COG1674	ftsk spoiiie
K5X85_RS35890	COG2186	Transcriptional regulator
K5X85_RS36015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5X85_RS36105	COG4221	oxidoreductase activity
K5X85_RS36140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5X85_RS36145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5X85_RS36150	COG0431	NADPH-dependent FMN reductase
K5X85_RS36155	COG0477	Major facilitator Superfamily
K5X85_RS36330	COG2124	cytochrome p450