locus-tag	class	description
IOD14_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IOD14_RS00010	COG0592	DNA-directed DNA polymerase activity
IOD14_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IOD14_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD14_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IOD14_RS00030	COG0187	DNA topoisomerase II activity
IOD14_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD14_RS00105	COG0705	Rhomboid family
IOD14_RS00120	COG3764	Sortase (surface protein transpeptidase)
IOD14_RS00135	COG3764	Sortase (surface protein transpeptidase)
IOD14_RS00140	COG3764	Sortase (surface protein transpeptidase)
IOD14_RS00145	COG0515	serine threonine protein kinase
IOD14_RS00150	COG0768	penicillin binding
IOD14_RS00165	COG1716	ATPase activity
IOD14_RS00170	COG1716	ATPase activity
IOD14_RS00180	COG0577	efflux transmembrane transporter activity
IOD14_RS00195	COG2197	response regulator
IOD14_RS00225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD14_RS00230	COG2151	metal-sulfur cluster biosynthetic enzyme
IOD14_RS00235	COG3396	Phenylacetate-CoA oxygenase
IOD14_RS00240	COG3460	Phenylacetate-CoA oxygenase
IOD14_RS00245	COG3396	Phenylacetate-CoA oxygenase
IOD14_RS00270	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS00275	COG1309	transcriptional regulator
IOD14_RS00280	COG1522	sequence-specific DNA binding
IOD14_RS00310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD14_RS00325	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS00325	COG3321	synthase
IOD14_RS00325	COG0604	alcohol dehydrogenase
IOD14_RS00340	COG0515	serine threonine protein kinase
IOD14_RS00365	COG0022	dehydrogenase e1 component
IOD14_RS00370	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD14_RS00440	COG1362	aminopeptidase activity
IOD14_RS00445	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS00460	COG1741	Belongs to the pirin family
IOD14_RS00475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IOD14_RS00495	COG3866	Pectate lyase
IOD14_RS00505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD14_RS00520	COG0583	DNA-binding transcription factor activity
IOD14_RS00540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD14_RS00580	COG1396	sequence-specific DNA binding
IOD14_RS00585	COG0701	Predicted permease
IOD14_RS00600	COG4552	Acetyltransferase involved in intracellular survival and related
IOD14_RS00630	COG0640	Transcriptional regulator
IOD14_RS00635	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD14_RS00640	COG1957	nucleoside hydrolase
IOD14_RS00650	COG1595	DNA-templated transcription, initiation
IOD14_RS00690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD14_RS00695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD14_RS00735	COG0366	Alpha amylase catalytic
IOD14_RS00780	COG4213	ABC transporter substrate-binding protein
IOD14_RS00790	COG4585	Histidine kinase
IOD14_RS00795	COG2197	response regulator
IOD14_RS00805	COG1595	DNA-templated transcription, initiation
IOD14_RS00820	COG3250	beta-galactosidase activity
IOD14_RS00825	COG0135	phosphoribosylanthranilate isomerase activity
IOD14_RS00845	COG2409	Drug exporters of the RND superfamily
IOD14_RS00850	COG4585	Histidine kinase
IOD14_RS00870	COG2755	lipolytic protein G-D-S-L family
IOD14_RS00870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IOD14_RS00890	COG0513	Belongs to the DEAD box helicase family
IOD14_RS00895	COG1278	Cold shock
IOD14_RS00920	COG0513	Belongs to the DEAD box helicase family
IOD14_RS00925	COG1278	Cold shock
IOD14_RS00960	COG2867	negative regulation of translational initiation
IOD14_RS00965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD14_RS00970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD14_RS00980	COG0662	Cupin 2, conserved barrel domain protein
IOD14_RS01010	COG4585	Histidine kinase
IOD14_RS01015	COG2197	response regulator
IOD14_RS01095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IOD14_RS01100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IOD14_RS01105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IOD14_RS01165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD14_RS01170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD14_RS01180	COG1408	metallophosphoesterase
IOD14_RS01280	COG1302	Protein conserved in bacteria
IOD14_RS01350	COG4656	Part of a membrane complex involved in electron transport
IOD14_RS01355	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IOD14_RS01370	COG2205	protein histidine kinase activity
IOD14_RS01375	COG0745	RESPONSE REGULATOR receiver
IOD14_RS01405	COG1404	Belongs to the peptidase S8 family
IOD14_RS01470	COG1609	Transcriptional regulator
IOD14_RS01525	COG0717	Belongs to the dCTP deaminase family
IOD14_RS01530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IOD14_RS01565	COG2181	nitrate reductase activity
IOD14_RS01565	COG0247	lactate metabolic process
IOD14_RS01570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD14_RS01575	COG0443	Heat shock 70 kDa protein
IOD14_RS01580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IOD14_RS01585	COG0484	heat shock protein binding
IOD14_RS01590	COG0789	Transcriptional regulator
IOD14_RS01600	COG4213	ABC transporter substrate-binding protein
IOD14_RS01605	COG1305	Transglutaminase-like
IOD14_RS01650	COG0542	response to heat
IOD14_RS01690	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IOD14_RS01705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IOD14_RS01710	COG0191	fructose-bisphosphate aldolase activity
IOD14_RS01715	COG0477	Major facilitator Superfamily
IOD14_RS01730	COG3844	kynureninase activity
IOD14_RS01755	COG4585	Histidine kinase
IOD14_RS01760	COG2197	response regulator
IOD14_RS01765	COG4585	Histidine kinase
IOD14_RS01770	COG2197	response regulator
IOD14_RS01775	COG0592	DNA-directed DNA polymerase activity
IOD14_RS01800	COG2124	cytochrome p450
IOD14_RS01810	COG3559	Exporter of polyketide antibiotics
IOD14_RS01815	COG1131	(ABC) transporter
IOD14_RS01830	COG4303	Ethanolamine ammonia lyase large subunit
IOD14_RS01835	COG4302	ethanolamine ammonia-lyase activity
IOD14_RS01845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOD14_RS01850	COG0737	Belongs to the 5'-nucleotidase family
IOD14_RS01870	COG1595	DNA-templated transcription, initiation
IOD14_RS01890	COG1802	Transcriptional regulator
IOD14_RS01895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD14_RS01900	COG0693	protein deglycase activity
IOD14_RS01920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IOD14_RS01925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOD14_RS01955	COG2205	protein histidine kinase activity
IOD14_RS01960	COG0745	RESPONSE REGULATOR receiver
IOD14_RS01975	COG1595	DNA-templated transcription, initiation
IOD14_RS02010	COG0701	Predicted permease
IOD14_RS02030	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD14_RS02030	COG2319	Wd-40 repeat
IOD14_RS02035	COG0640	Transcriptional regulator
IOD14_RS02040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IOD14_RS02050	COG0697	spore germination
IOD14_RS02055	COG0583	DNA-binding transcription factor activity
IOD14_RS02070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD14_RS02085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD14_RS02110	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS02195	COG1408	metallophosphoesterase
IOD14_RS02215	COG0003	Pfam Anion-transporting ATPase
IOD14_RS02240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD14_RS02270	COG2267	carboxylic ester hydrolase activity
IOD14_RS02280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOD14_RS02285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD14_RS02360	COG1111	helicase
IOD14_RS02360	COG1205	dead DEAH box helicase
IOD14_RS02365	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD14_RS02370	COG2172	sigma factor antagonist activity
IOD14_RS02375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IOD14_RS02400	COG1754	DNA topoisomerase type I activity
IOD14_RS02400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOD14_RS02405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IOD14_RS02445	COG3250	beta-galactosidase activity
IOD14_RS02475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD14_RS02475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD14_RS02500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOD14_RS02505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOD14_RS02510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD14_RS02515	COG0254	rRNA binding
IOD14_RS02525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOD14_RS02560	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS02565	COG2318	DinB family
IOD14_RS02585	COG0076	glutamate decarboxylase activity
IOD14_RS02595	COG0789	Transcriptional regulator
IOD14_RS02600	COG0393	Putative heavy-metal-binding
IOD14_RS02605	COG0586	Pfam SNARE associated Golgi protein
IOD14_RS02615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOD14_RS02620	COG2027	D-alanyl-D-alanine carboxypeptidase
IOD14_RS02630	COG0037	tRNA processing
IOD14_RS02645	COG0302	gtp cyclohydrolase
IOD14_RS02655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOD14_RS02660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD14_RS02700	COG0649	NAD binding
IOD14_RS02740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IOD14_RS02745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IOD14_RS02755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IOD14_RS02775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IOD14_RS02810	COG0739	heme binding
IOD14_RS02820	COG0477	Major facilitator Superfamily
IOD14_RS02835	COG2205	protein histidine kinase activity
IOD14_RS02840	COG0745	RESPONSE REGULATOR receiver
IOD14_RS02850	COG1595	DNA-templated transcription, initiation
IOD14_RS02855	COG1194	a g-specific adenine glycosylase
IOD14_RS02865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IOD14_RS02885	COG0248	Ppx GppA phosphatase
IOD14_RS02890	COG1082	Xylose isomerase domain protein TIM barrel
IOD14_RS02900	COG1309	transcriptional regulator
IOD14_RS02905	COG0129	dihydroxy-acid dehydratase activity
IOD14_RS02910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS02910	COG0515	serine threonine protein kinase
IOD14_RS02940	COG0842	Transport permease protein
IOD14_RS02940	COG1129	ABC transporter
IOD14_RS02950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOD14_RS02955	COG0180	Tryptophanyl-tRNA synthetase
IOD14_RS02975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD14_RS02985	COG0738	Major facilitator superfamily
IOD14_RS02990	COG0123	including yeast histone deacetylase and acetoin utilization protein
IOD14_RS03040	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IOD14_RS03045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IOD14_RS03050	COG0181	hydroxymethylbilane synthase activity
IOD14_RS03065	COG0113	porphobilinogen synthase activity
IOD14_RS03070	COG3152	Membrane
IOD14_RS03085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD14_RS03125	COG0018	arginyl-trna synthetase
IOD14_RS03130	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IOD14_RS03150	COG1690	Belongs to the RtcB family
IOD14_RS03165	COG1742	UPF0060 membrane protein
IOD14_RS03175	COG1733	regulation of RNA biosynthetic process
IOD14_RS03180	COG0604	alcohol dehydrogenase
IOD14_RS03190	COG2207	Transcriptional regulator
IOD14_RS03200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS03235	COG0477	Major facilitator Superfamily
IOD14_RS03250	COG1609	Transcriptional regulator
IOD14_RS03275	COG1940	carbohydrate kinase activity
IOD14_RS03280	COG2182	Extracellular solute-binding protein
IOD14_RS03285	COG1175	transmembrane transport
IOD14_RS03290	COG0395	ABC-type sugar transport system, permease component
IOD14_RS03295	COG2723	6-phospho-beta-galactosidase activity
IOD14_RS03305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IOD14_RS03310	COG0406	alpha-ribazole phosphatase activity
IOD14_RS03320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD14_RS03325	COG0785	Cytochrome C biogenesis protein
IOD14_RS03330	COG1333	cytochrome c biogenesis protein
IOD14_RS03335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD14_RS03390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD14_RS03400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOD14_RS03410	COG0163	prenyltransferase activity
IOD14_RS03420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IOD14_RS03435	COG1309	transcriptional regulator
IOD14_RS03450	COG0183	Belongs to the thiolase family
IOD14_RS03510	COG1053	succinate dehydrogenase
IOD14_RS03515	COG2226	methyltransferase
IOD14_RS03530	COG1396	sequence-specific DNA binding
IOD14_RS03535	COG1278	Cold shock
IOD14_RS03540	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IOD14_RS03545	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS03545	COG0515	serine threonine protein kinase
IOD14_RS03555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IOD14_RS03565	COG3979	chitinase
IOD14_RS03585	COG2226	methyltransferase
IOD14_RS03605	COG0242	peptide deformylase activity
IOD14_RS03620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD14_RS03625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD14_RS03630	COG0649	NAD binding
IOD14_RS03640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IOD14_RS03645	COG1034	ATP synthesis coupled electron transport
IOD14_RS03650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IOD14_RS03655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD14_RS03660	COG0839	Belongs to the complex I subunit 6 family
IOD14_RS03665	COG0713	ATP synthesis coupled electron transport
IOD14_RS03670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD14_RS03680	COG1007	ATP synthesis coupled electron transport
IOD14_RS03690	COG0514	ATP-dependent DNA helicase (RecQ)
IOD14_RS03730	COG1175	transmembrane transport
IOD14_RS03735	COG0395	ABC-type sugar transport system, permease component
IOD14_RS03745	COG0561	phosphatase activity
IOD14_RS03760	COG0142	geranyltranstransferase activity
IOD14_RS03785	COG0655	NAD(P)H dehydrogenase (quinone) activity
IOD14_RS03790	COG0154	amidase activity
IOD14_RS03820	COG0702	epimerase
IOD14_RS03825	COG1733	regulation of RNA biosynthetic process
IOD14_RS03845	COG1013	pyruvate-flavodoxin oxidoreductase activity
IOD14_RS03850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IOD14_RS03850	COG0674	pyruvate-flavodoxin oxidoreductase activity
IOD14_RS03870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD14_RS03875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD14_RS03880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IOD14_RS03885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD14_RS03890	COG0839	Belongs to the complex I subunit 6 family
IOD14_RS03895	COG0713	ATP synthesis coupled electron transport
IOD14_RS03900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD14_RS03910	COG1007	ATP synthesis coupled electron transport
IOD14_RS03915	COG0501	Belongs to the peptidase M48B family
IOD14_RS03920	COG3304	Inner membrane component domain
IOD14_RS03935	COG2261	transglycosylase associated protein
IOD14_RS03940	COG1666	GTP binding
IOD14_RS04010	COG0739	heme binding
IOD14_RS04010	COG0741	lytic transglycosylase activity
IOD14_RS04010	COG1196	nuclear chromosome segregation
IOD14_RS04110	COG0702	epimerase
IOD14_RS04130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD14_RS04135	COG2030	dehydratase
IOD14_RS04150	COG0477	Major facilitator Superfamily
IOD14_RS04155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IOD14_RS04175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD14_RS04180	COG0436	Aminotransferase
IOD14_RS04195	COG0250	Participates in transcription elongation, termination and antitermination
IOD14_RS04200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IOD14_RS04205	COG0081	regulation of translation
IOD14_RS04220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IOD14_RS04225	COG0222	ribosome binding
IOD14_RS04230	COG0085	RNA polymerase activity
IOD14_RS04235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IOD14_RS04245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IOD14_RS04250	COG0049	tRNA binding
IOD14_RS04255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD14_RS04260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD14_RS04270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IOD14_RS04270	COG2755	lipolytic protein G-D-S-L family
IOD14_RS04285	COG0051	transcription antitermination factor activity, RNA binding
IOD14_RS04290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IOD14_RS04295	COG0088	Forms part of the polypeptide exit tunnel
IOD14_RS04300	COG0089	rRNA binding
IOD14_RS04305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IOD14_RS04310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOD14_RS04315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IOD14_RS04320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IOD14_RS04325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IOD14_RS04330	COG0255	Belongs to the universal ribosomal protein uL29 family
IOD14_RS04335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IOD14_RS04340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IOD14_RS04345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IOD14_RS04350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IOD14_RS04355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOD14_RS04360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IOD14_RS04365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IOD14_RS04370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IOD14_RS04375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IOD14_RS04380	COG1841	ribosomal large subunit assembly
IOD14_RS04385	COG0200	Binds to the 23S rRNA
IOD14_RS04395	COG0563	adenylate kinase activity
IOD14_RS04405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IOD14_RS04410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOD14_RS04415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IOD14_RS04420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IOD14_RS04425	COG0202	RNA polymerase activity
IOD14_RS04430	COG0203	ribosomal protein L17
IOD14_RS04440	COG0101	tRNA pseudouridine synthase activity
IOD14_RS04445	COG2755	lipolytic protein G-D-S-L family
IOD14_RS04445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IOD14_RS04450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IOD14_RS04475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IOD14_RS04480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IOD14_RS04485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD14_RS04495	COG1072	(Pantothenic acid kinase))
IOD14_RS04505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD14_RS04515	COG0736	holo-[acyl-carrier-protein] synthase activity
IOD14_RS04530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD14_RS04540	COG0802	atpase or kinase
IOD14_RS04565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IOD14_RS04575	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD14_RS04580	COG1609	Transcriptional regulator
IOD14_RS04600	COG4941	Belongs to the sigma-70 factor family
IOD14_RS04615	COG0726	polysaccharide deacetylase
IOD14_RS04620	COG0726	polysaccharide deacetylase
IOD14_RS04625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IOD14_RS04630	COG0459	protein refolding
IOD14_RS04640	COG4221	oxidoreductase activity
IOD14_RS04650	COG0583	DNA-binding transcription factor activity
IOD14_RS04665	COG1595	DNA-templated transcription, initiation
IOD14_RS04675	COG0516	GMP reductase activity
IOD14_RS04685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD14_RS04700	COG0515	serine threonine protein kinase
IOD14_RS04700	COG2815	serine threonine protein kinase
IOD14_RS04705	COG0515	serine threonine protein kinase
IOD14_RS04710	COG0515	serine threonine protein kinase
IOD14_RS04715	COG0515	serine threonine protein kinase
IOD14_RS04730	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS04755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD14_RS04755	COG0519	Catalyzes the synthesis of GMP from XMP
IOD14_RS04800	COG2197	response regulator
IOD14_RS04805	COG0791	NLP P60 protein
IOD14_RS04830	COG0739	heme binding
IOD14_RS04840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS04840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS04855	COG0714	Associated with various cellular activities
IOD14_RS04860	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IOD14_RS04865	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IOD14_RS04875	COG0045	succinate-CoA ligase (ADP-forming) activity
IOD14_RS04905	COG0138	bifunctional purine biosynthesis protein purh
IOD14_RS04920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOD14_RS04940	COG0039	L-malate dehydrogenase activity
IOD14_RS04950	COG0454	-acetyltransferase
IOD14_RS04975	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS04985	COG0517	IMP dehydrogenase activity
IOD14_RS04985	COG4175	Glycine betaine
IOD14_RS04990	COG4176	ABC-type proline glycine betaine transport system permease component
IOD14_RS05005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS05010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS05015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD14_RS05020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS05040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD14_RS05050	COG3224	Antibiotic biosynthesis monooxygenase
IOD14_RS05065	COG0754	glutathionylspermidine amidase activity
IOD14_RS05075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD14_RS05100	COG0180	Tryptophanyl-tRNA synthetase
IOD14_RS05125	COG1295	ribonuclease BN
IOD14_RS05130	COG1686	Belongs to the peptidase S11 family
IOD14_RS05135	COG1408	metallophosphoesterase
IOD14_RS05150	COG2205	protein histidine kinase activity
IOD14_RS05155	COG0745	RESPONSE REGULATOR receiver
IOD14_RS05160	COG2409	Drug exporters of the RND superfamily
IOD14_RS05165	COG1309	transcriptional regulator
IOD14_RS05235	COG1053	succinate dehydrogenase
IOD14_RS05245	COG2009	succinate dehydrogenase
IOD14_RS05300	COG3903	Transcriptional regulator
IOD14_RS05300	COG3629	intracellular signal transduction
IOD14_RS05360	COG2311	Membrane
IOD14_RS05400	COG3903	Transcriptional regulator
IOD14_RS05400	COG3629	intracellular signal transduction
IOD14_RS05410	COG1595	DNA-templated transcription, initiation
IOD14_RS05425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS05425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS05450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IOD14_RS05460	COG1216	Glycosyl transferase, family 2
IOD14_RS05475	COG2089	acid synthase
IOD14_RS05495	COG3209	COG3209 Rhs family protein
IOD14_RS05520	COG2226	methyltransferase
IOD14_RS05530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD14_RS05530	COG1473	amidohydrolase
IOD14_RS05535	COG1744	ABC transporter substrate-binding protein PnrA-like
IOD14_RS05540	COG3845	ABC transporter
IOD14_RS05545	COG4603	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS05550	COG1079	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS05585	COG2814	Major facilitator Superfamily
IOD14_RS05590	COG0583	DNA-binding transcription factor activity
IOD14_RS05600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD14_RS05625	COG2205	protein histidine kinase activity
IOD14_RS05630	COG0745	RESPONSE REGULATOR receiver
IOD14_RS05635	COG1595	DNA-templated transcription, initiation
IOD14_RS05655	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS05660	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS05685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD14_RS05710	COG4770	biotin carboxylase activity
IOD14_RS05720	COG0424	maF-like protein
IOD14_RS05735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD14_RS05745	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD14_RS05755	COG1024	Enoyl-CoA hydratase
IOD14_RS05765	COG2986	histidine ammonia-lyase
IOD14_RS05800	COG1136	(ABC) transporter
IOD14_RS05805	COG1404	Belongs to the peptidase S8 family
IOD14_RS05810	COG1595	DNA-templated transcription, initiation
IOD14_RS05825	COG1064	alcohol dehydrogenase
IOD14_RS05845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD14_RS05875	COG2255	four-way junction helicase activity
IOD14_RS05880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD14_RS05895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD14_RS05905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD14_RS05920	COG2255	four-way junction helicase activity
IOD14_RS05925	COG1331	Highly conserved protein containing a thioredoxin domain
IOD14_RS05935	COG1309	transcriptional regulator
IOD14_RS05940	COG0477	Major facilitator Superfamily
IOD14_RS05950	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IOD14_RS05985	COG0436	Aminotransferase
IOD14_RS06000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IOD14_RS06015	COG1414	Transcriptional regulator
IOD14_RS06020	COG0251	oxidation-reduction process
IOD14_RS06025	COG2610	gluconate transmembrane transporter activity
IOD14_RS06065	COG2894	cell division
IOD14_RS06095	COG3850	Histidine kinase
IOD14_RS06135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOD14_RS06150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOD14_RS06155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IOD14_RS06160	COG0741	lytic transglycosylase activity
IOD14_RS06210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD14_RS06225	COG0114	fumarate hydratase activity
IOD14_RS06230	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD14_RS06230	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD14_RS06255	COG0778	Nitroreductase
IOD14_RS06260	COG1722	exodeoxyribonuclease VII activity
IOD14_RS06265	COG1570	exodeoxyribonuclease VII activity
IOD14_RS06275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IOD14_RS06290	COG0012	GTP binding
IOD14_RS06295	COG0583	DNA-binding transcription factor activity
IOD14_RS06365	COG1053	succinate dehydrogenase
IOD14_RS06385	COG1217	gtp-binding protein TYPA
IOD14_RS06390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS06395	COG0747	negative chemotaxis
IOD14_RS06400	COG0601	transmembrane transport
IOD14_RS06405	COG0444	Belongs to the ABC transporter superfamily
IOD14_RS06410	COG4608	Belongs to the ABC transporter superfamily
IOD14_RS06420	COG0601	transmembrane transport
IOD14_RS06425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS06435	COG4608	Belongs to the ABC transporter superfamily
IOD14_RS06450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD14_RS06465	COG1131	(ABC) transporter
IOD14_RS06475	COG4585	Histidine kinase
IOD14_RS06480	COG2197	response regulator
IOD14_RS06515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD14_RS06525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD14_RS06535	COG2818	Glycosylase
IOD14_RS06540	COG1024	Enoyl-CoA hydratase
IOD14_RS06555	COG1595	DNA-templated transcription, initiation
IOD14_RS06570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD14_RS06635	COG0598	Magnesium transport protein CorA
IOD14_RS06645	COG2814	Major facilitator Superfamily
IOD14_RS06660	COG2095	MarC family integral membrane protein
IOD14_RS06670	COG1432	Conserved Protein
IOD14_RS06680	COG0513	Belongs to the DEAD box helicase family
IOD14_RS06720	COG0747	negative chemotaxis
IOD14_RS06725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS06790	COG0210	DNA helicase
IOD14_RS06795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD14_RS06800	COG2816	NAD+ diphosphatase activity
IOD14_RS06840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOD14_RS06895	COG3480	Lon protease (S16) C-terminal proteolytic domain
IOD14_RS06905	COG1615	UPF0182 protein
IOD14_RS06950	COG0483	inositol monophosphate 1-phosphatase activity
IOD14_RS06970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOD14_RS06980	COG2135	peptidase activity
IOD14_RS06990	COG1595	DNA-templated transcription, initiation
IOD14_RS06995	COG5662	AntiSigma factor
IOD14_RS07020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IOD14_RS07020	COG2199	diguanylate cyclase activity
IOD14_RS07035	COG0242	peptide deformylase activity
IOD14_RS07045	COG2124	cytochrome p450
IOD14_RS07065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD14_RS07095	COG1966	Carbon starvation protein
IOD14_RS07100	COG2188	Transcriptional regulator
IOD14_RS07105	COG2182	Extracellular solute-binding protein
IOD14_RS07110	COG1175	transmembrane transport
IOD14_RS07115	COG0395	ABC-type sugar transport system, permease component
IOD14_RS07120	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD14_RS07125	COG0363	glucosamine-6-phosphate deaminase activity
IOD14_RS07130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD14_RS07160	COG1597	lipid kinase activity
IOD14_RS07190	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IOD14_RS07200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD14_RS07205	COG0142	geranyltranstransferase activity
IOD14_RS07210	COG0456	acetyltransferase
IOD14_RS07225	COG4941	Belongs to the sigma-70 factor family
IOD14_RS07265	COG2326	polyphosphate kinase activity
IOD14_RS07285	COG4106	trans-aconitate 2-methyltransferase activity
IOD14_RS07290	COG1126	abc transporter atp-binding protein
IOD14_RS07295	COG0765	amino acid transport
IOD14_RS07305	COG0281	malic enzyme
IOD14_RS07310	COG0604	alcohol dehydrogenase
IOD14_RS07320	COG0542	response to heat
IOD14_RS07345	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD14_RS07345	COG0567	Dehydrogenase, E1 component
IOD14_RS07350	COG2205	protein histidine kinase activity
IOD14_RS07355	COG0745	RESPONSE REGULATOR receiver
IOD14_RS07380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD14_RS07470	COG2205	protein histidine kinase activity
IOD14_RS07490	COG3285	dna ligase
IOD14_RS07490	COG1793	dna ligase
IOD14_RS07495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IOD14_RS07510	COG1595	DNA-templated transcription, initiation
IOD14_RS07520	COG3594	Acyltransferase
IOD14_RS07555	COG0018	arginyl-trna synthetase
IOD14_RS07555	COG0018	arginyl-trna synthetase
IOD14_RS07560	COG0019	diaminopimelate decarboxylase activity
IOD14_RS07565	COG0460	homoserine dehydrogenase
IOD14_RS07570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD14_RS07575	COG0083	homoserine kinase activity
IOD14_RS07595	COG0254	rRNA binding
IOD14_RS07600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IOD14_RS07605	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD14_RS07615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOD14_RS07620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD14_RS07625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD14_RS07640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD14_RS07645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IOD14_RS07650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD14_RS07655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IOD14_RS07660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IOD14_RS07665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IOD14_RS07670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IOD14_RS07685	COG2197	response regulator
IOD14_RS07690	COG4585	Histidine kinase
IOD14_RS07710	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS07725	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IOD14_RS07760	COG1131	(ABC) transporter
IOD14_RS07775	COG0346	lactoylglutathione lyase activity
IOD14_RS07780	COG0183	Belongs to the thiolase family
IOD14_RS07800	COG0745	RESPONSE REGULATOR receiver
IOD14_RS07855	COG3386	PFAM SMP-30 Gluconolaconase
IOD14_RS07885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS07885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS07935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOD14_RS07940	COG0280	phosphate acetyltransferase
IOD14_RS07940	COG0857	belongs to the CobB CobQ family
IOD14_RS07945	COG0205	6-phosphofructokinase activity
IOD14_RS07960	COG4565	transcriptional regulatory protein
IOD14_RS07965	COG3290	protein histidine kinase activity
IOD14_RS07970	COG1301	dicarboxylic acid transport
IOD14_RS07995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD14_RS08005	COG1522	sequence-specific DNA binding
IOD14_RS08030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IOD14_RS08035	COG3281	Trehalose synthase
IOD14_RS08045	COG0366	Alpha amylase catalytic
IOD14_RS08055	COG0058	SHG alpha-glucan phosphorylase activity
IOD14_RS08075	COG1132	(ABC) transporter
IOD14_RS08080	COG1132	(ABC) transporter
IOD14_RS08085	COG1132	(ABC) transporter
IOD14_RS08090	COG1132	(ABC) transporter
IOD14_RS08095	COG1131	(ABC) transporter
IOD14_RS08105	COG4585	Histidine kinase
IOD14_RS08110	COG2197	response regulator
IOD14_RS08115	COG3119	arylsulfatase activity
IOD14_RS08125	COG1376	ErfK ybiS ycfS ynhG family protein
IOD14_RS08130	COG1376	ErfK ybiS ycfS ynhG family protein
IOD14_RS08205	COG1760	l-serine dehydratase
IOD14_RS08210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD14_RS08215	COG0509	glycine decarboxylation via glycine cleavage system
IOD14_RS08220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IOD14_RS08240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS08245	COG0747	negative chemotaxis
IOD14_RS08255	COG0444	Belongs to the ABC transporter superfamily
IOD14_RS08260	COG4608	Belongs to the ABC transporter superfamily
IOD14_RS08270	COG2860	membrane
IOD14_RS08285	COG2378	regulation of single-species biofilm formation
IOD14_RS08295	COG1309	transcriptional regulator
IOD14_RS08315	COG2132	Multicopper oxidase
IOD14_RS08320	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD14_RS08325	COG0482	sulfurtransferase activity
IOD14_RS08340	COG1611	Belongs to the LOG family
IOD14_RS08345	COG4221	oxidoreductase activity
IOD14_RS08355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD14_RS08365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD14_RS08370	COG0154	amidase activity
IOD14_RS08380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD14_RS08395	COG2409	Drug exporters of the RND superfamily
IOD14_RS08400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD14_RS08415	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD14_RS08415	COG1672	PFAM Archaeal ATPase
IOD14_RS08425	COG2133	pyrroloquinoline quinone binding
IOD14_RS08430	COG0667	Aldo Keto reductase
IOD14_RS08440	COG5001	Diguanylate cyclase
IOD14_RS08450	COG0440	acetolactate synthase activity
IOD14_RS08455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOD14_RS08460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD14_RS08465	COG0477	Major facilitator Superfamily
IOD14_RS08475	COG3835	regulator
IOD14_RS08480	COG0506	proline dehydrogenase activity
IOD14_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS08495	COG0473	3-isopropylmalate dehydrogenase activity
IOD14_RS08500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD14_RS08505	COG0831	urea catabolic process
IOD14_RS08505	COG0832	Belongs to the urease beta subunit family
IOD14_RS08510	COG0804	urea catabolic process
IOD14_RS08515	COG2957	Belongs to the agmatine deiminase family
IOD14_RS08540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD14_RS08570	COG2319	Wd-40 repeat
IOD14_RS08570	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD14_RS08575	COG2353	YceI-like domain
IOD14_RS08585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD14_RS08605	COG2018	Roadblock/LC7 domain
IOD14_RS08625	COG2018	Roadblock/LC7 domain
IOD14_RS08630	COG5002	protein histidine kinase activity
IOD14_RS08650	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD14_RS08655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD14_RS08705	COG1414	Transcriptional regulator
IOD14_RS08710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IOD14_RS08715	COG0066	3-isopropylmalate dehydratase activity
IOD14_RS08725	COG0776	regulation of translation
IOD14_RS08735	COG1920	GTP binding
IOD14_RS08745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOD14_RS08750	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD14_RS08770	COG0351	phosphomethylpyrimidine kinase
IOD14_RS08775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOD14_RS08790	COG0326	Molecular chaperone. Has ATPase activity
IOD14_RS08800	COG0742	ribosomal rna small subunit methyltransferase
IOD14_RS08805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IOD14_RS08820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IOD14_RS08825	COG0571	ribonuclease III activity
IOD14_RS08830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD14_RS08835	COG1733	regulation of RNA biosynthetic process
IOD14_RS08840	COG2340	Cysteine-rich secretory protein family
IOD14_RS08845	COG1254	Belongs to the acylphosphatase family
IOD14_RS08860	COG0477	Major facilitator Superfamily
IOD14_RS08900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IOD14_RS08920	COG0442	prolyl-tRNA aminoacylation
IOD14_RS08930	COG0228	four-way junction DNA binding
IOD14_RS08935	COG1837	Belongs to the UPF0109 family
IOD14_RS08940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOD14_RS08945	COG0336	Belongs to the RNA methyltransferase TrmD family
IOD14_RS08950	COG0335	large ribosomal subunit rRNA binding
IOD14_RS08960	COG0681	Belongs to the peptidase S26 family
IOD14_RS08965	COG0681	Belongs to the peptidase S26 family
IOD14_RS08970	COG0681	Belongs to the peptidase S26 family
IOD14_RS08985	COG0792	nuclease activity
IOD14_RS09000	COG1191	sigma factor activity
IOD14_RS09015	COG0052	Belongs to the universal ribosomal protein uS2 family
IOD14_RS09020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IOD14_RS09025	COG0528	UMP kinase activity
IOD14_RS09030	COG0233	cytoplasmic translational termination
IOD14_RS09035	COG0575	Belongs to the CDS family
IOD14_RS09060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IOD14_RS09070	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IOD14_RS09075	COG3842	ATPase activity
IOD14_RS09110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD14_RS09120	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS09140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS09150	COG1733	regulation of RNA biosynthetic process
IOD14_RS09155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOD14_RS09160	COG0584	glycerophosphoryl diester phosphodiesterase
IOD14_RS09165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD14_RS09190	COG3842	ATPase activity
IOD14_RS09200	COG1177	transmembrane transport
IOD14_RS09205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD14_RS09230	COG2508	Transcriptional regulator
IOD14_RS09230	COG2508	Transcriptional regulator
IOD14_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS09250	COG4209	transmembrane transport
IOD14_RS09255	COG0395	ABC-type sugar transport system, permease component
IOD14_RS09280	COG1605	Chorismate mutase
IOD14_RS09300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IOD14_RS09305	COG0750	zinc metalloprotease
IOD14_RS09315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IOD14_RS09330	COG0442	prolyl-tRNA aminoacylation
IOD14_RS09350	COG0779	Required for maturation of 30S ribosomal subunits
IOD14_RS09365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IOD14_RS09375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IOD14_RS09380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOD14_RS09400	COG0455	bacterial-type flagellum organization
IOD14_RS09435	COG1404	Belongs to the peptidase S8 family
IOD14_RS09450	COG1404	Belongs to the peptidase S8 family
IOD14_RS09550	COG1674	ftsk spoiiie
IOD14_RS09560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IOD14_RS09565	COG1185	polyribonucleotide nucleotidyltransferase activity
IOD14_RS09570	COG0612	Peptidase, M16
IOD14_RS09575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IOD14_RS09595	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IOD14_RS09600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS09605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IOD14_RS09635	COG2770	Histidine kinase
IOD14_RS09635	COG2208	phosphoserine phosphatase activity
IOD14_RS09640	COG3850	Histidine kinase
IOD14_RS09640	COG3437	response regulator, receiver
IOD14_RS09640	COG4999	Histidine kinase
IOD14_RS09640	COG2205	protein histidine kinase activity
IOD14_RS09650	COG1674	ftsk spoiiie
IOD14_RS09660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD14_RS09670	COG1546	Belongs to the CinA family
IOD14_RS09670	COG1058	Belongs to the CinA family
IOD14_RS09675	COG1396	sequence-specific DNA binding
IOD14_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS09685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD14_RS09690	COG1201	RNA secondary structure unwinding
IOD14_RS09720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IOD14_RS09745	COG0765	amino acid transport
IOD14_RS09750	COG0765	amino acid transport
IOD14_RS09755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD14_RS09760	COG1126	abc transporter atp-binding protein
IOD14_RS09765	COG0745	RESPONSE REGULATOR receiver
IOD14_RS09770	COG2205	protein histidine kinase activity
IOD14_RS09775	COG2358	TRAP transporter, solute receptor (TAXI family
IOD14_RS09790	COG4585	Histidine kinase
IOD14_RS09795	COG2197	response regulator
IOD14_RS09810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS09815	COG0137	argininosuccinate synthase activity
IOD14_RS09820	COG2197	response regulator
IOD14_RS09825	COG4585	Histidine kinase
IOD14_RS09880	COG2843	Capsule synthesis protein
IOD14_RS09885	COG2197	response regulator
IOD14_RS09890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD14_RS09915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IOD14_RS09925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IOD14_RS09930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD14_RS09940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD14_RS09970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD14_RS09975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IOD14_RS09980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD14_RS10000	COG0588	phosphoglycerate mutase activity
IOD14_RS10020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOD14_RS10035	COG0514	ATP-dependent DNA helicase (RecQ)
IOD14_RS10060	COG2186	Transcriptional regulator
IOD14_RS10065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD14_RS10080	COG0187	DNA topoisomerase II activity
IOD14_RS10095	COG2197	response regulator
IOD14_RS10105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD14_RS10110	COG4565	transcriptional regulatory protein
IOD14_RS10120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD14_RS10130	COG4565	transcriptional regulatory protein
IOD14_RS10135	COG3290	protein histidine kinase activity
IOD14_RS10150	COG0372	Belongs to the citrate synthase family
IOD14_RS10165	COG0523	cobalamin synthesis protein
IOD14_RS10170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD14_RS10175	COG0612	Peptidase, M16
IOD14_RS10190	COG1802	Transcriptional regulator
IOD14_RS10195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD14_RS10200	COG1042	CoA-binding domain protein
IOD14_RS10200	COG0045	succinate-CoA ligase (ADP-forming) activity
IOD14_RS10200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD14_RS10215	COG1435	thymidine kinase activity
IOD14_RS10245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IOD14_RS10250	COG0483	inositol monophosphate 1-phosphatase activity
IOD14_RS10260	COG0745	RESPONSE REGULATOR receiver
IOD14_RS10265	COG2205	protein histidine kinase activity
IOD14_RS10290	COG0756	dUTP diphosphatase activity
IOD14_RS10305	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD14_RS10305	COG1136	(ABC) transporter
IOD14_RS10335	COG0569	domain protein
IOD14_RS10340	COG0531	amino acid
IOD14_RS10345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD14_RS10355	COG1131	(ABC) transporter
IOD14_RS10360	COG1725	Transcriptional regulator
IOD14_RS10380	COG1113	amino acid transport
IOD14_RS10385	COG0069	glutamate synthase activity
IOD14_RS10390	COG0028	Belongs to the TPP enzyme family
IOD14_RS10395	COG1191	sigma factor activity
IOD14_RS10400	COG1295	ribonuclease BN
IOD14_RS10405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD14_RS10410	COG0436	Aminotransferase
IOD14_RS10425	COG0243	molybdopterin cofactor binding
IOD14_RS10465	COG1799	cell septum assembly
IOD14_RS10500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOD14_RS10515	COG2235	arginine
IOD14_RS10520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IOD14_RS10530	COG1024	Enoyl-CoA hydratase
IOD14_RS10585	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD14_RS10605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOD14_RS10615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOD14_RS10620	COG2205	protein histidine kinase activity
IOD14_RS10640	COG3537	Alpha-1,2-mannosidase
IOD14_RS10645	COG3458	cephalosporin-C deacetylase activity
IOD14_RS10650	COG4209	transmembrane transport
IOD14_RS10655	COG0395	ABC-type sugar transport system, permease component
IOD14_RS10690	COG1653	transport
IOD14_RS10695	COG1175	transmembrane transport
IOD14_RS10700	COG0395	ABC-type sugar transport system, permease component
IOD14_RS10705	COG1940	carbohydrate kinase activity
IOD14_RS10710	COG4213	ABC transporter substrate-binding protein
IOD14_RS10720	COG4214	carbohydrate transport
IOD14_RS10725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IOD14_RS10730	COG0531	amino acid
IOD14_RS10750	COG1024	Enoyl-CoA hydratase
IOD14_RS10750	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS10755	COG0183	Belongs to the thiolase family
IOD14_RS10760	COG1609	Transcriptional regulator
IOD14_RS10765	COG3250	beta-galactosidase activity
IOD14_RS10775	COG1175	transmembrane transport
IOD14_RS10780	COG0395	ABC-type sugar transport system, permease component
IOD14_RS10785	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IOD14_RS10800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IOD14_RS10815	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD14_RS10830	COG3253	May function as heme-dependent peroxidase
IOD14_RS10850	COG3220	belongs to the UPF0276 family
IOD14_RS10870	COG0723	plastoquinol--plastocyanin reductase activity
IOD14_RS10870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD14_RS10875	COG2326	polyphosphate kinase activity
IOD14_RS10885	COG0330	HflC and HflK could
IOD14_RS10920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD14_RS10925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD14_RS10930	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD14_RS10950	COG0395	ABC-type sugar transport system, permease component
IOD14_RS10955	COG1175	transmembrane transport
IOD14_RS10975	COG1737	Transcriptional regulator
IOD14_RS10980	COG4821	SIS domain
IOD14_RS10985	COG3291	Pkd domain containing protein
IOD14_RS10985	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IOD14_RS11005	COG3903	Transcriptional regulator
IOD14_RS11005	COG3629	intracellular signal transduction
IOD14_RS11015	COG1595	DNA-templated transcription, initiation
IOD14_RS11020	COG3883	PFAM NLP P60 protein
IOD14_RS11020	COG0791	NLP P60 protein
IOD14_RS11035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD14_RS11040	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS11055	COG0747	negative chemotaxis
IOD14_RS11060	COG0601	transmembrane transport
IOD14_RS11100	COG0745	RESPONSE REGULATOR receiver
IOD14_RS11105	COG5002	protein histidine kinase activity
IOD14_RS11110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD14_RS11115	COG2205	protein histidine kinase activity
IOD14_RS11120	COG0745	RESPONSE REGULATOR receiver
IOD14_RS11135	COG1477	protein flavinylation
IOD14_RS11150	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IOD14_RS11160	COG1174	glycine betaine transport
IOD14_RS11165	COG1174	glycine betaine transport
IOD14_RS11180	COG2018	Roadblock/LC7 domain
IOD14_RS11185	COG5002	protein histidine kinase activity
IOD14_RS11195	COG1940	carbohydrate kinase activity
IOD14_RS11195	COG1846	Transcriptional regulator
IOD14_RS11220	COG1940	carbohydrate kinase activity
IOD14_RS11260	COG3340	Belongs to the peptidase S51 family
IOD14_RS11285	COG1404	Belongs to the peptidase S8 family
IOD14_RS11300	COG1309	transcriptional regulator
IOD14_RS11315	COG3903	Transcriptional regulator
IOD14_RS11315	COG3629	intracellular signal transduction
IOD14_RS11325	COG0504	CTP synthase activity
IOD14_RS11335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD14_RS11340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD14_RS11345	COG1280	lysine exporter protein (LysE YggA)
IOD14_RS11430	COG0662	Cupin 2, conserved barrel domain protein
IOD14_RS11440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD14_RS11445	COG2867	negative regulation of translational initiation
IOD14_RS11455	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS11480	COG0300	oxidoreductase activity
IOD14_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS11495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS11500	COG1819	glycosyl
IOD14_RS11505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS11510	COG2867	negative regulation of translational initiation
IOD14_RS11510	COG2226	methyltransferase
IOD14_RS11515	COG0367	asparagine synthase
IOD14_RS11520	COG0477	Major facilitator Superfamily
IOD14_RS11530	COG2409	Drug exporters of the RND superfamily
IOD14_RS11540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD14_RS11550	COG2197	response regulator
IOD14_RS11590	COG0583	DNA-binding transcription factor activity
IOD14_RS11600	COG1175	transmembrane transport
IOD14_RS11615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD14_RS11625	COG2409	Drug exporters of the RND superfamily
IOD14_RS11640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IOD14_RS11655	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IOD14_RS11680	COG0529	Catalyzes the synthesis of activated sulfate
IOD14_RS11685	COG0175	sulfate reduction
IOD14_RS11715	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS11720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD14_RS11725	COG2423	ornithine cyclodeaminase activity
IOD14_RS11740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD14_RS11795	COG1609	Transcriptional regulator
IOD14_RS11815	COG1609	Transcriptional regulator
IOD14_RS11825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS11835	COG2326	polyphosphate kinase activity
IOD14_RS11840	COG2040	homocysteine
IOD14_RS11865	COG2755	lipolytic protein G-D-S-L family
IOD14_RS11905	COG1131	(ABC) transporter
IOD14_RS11915	COG0395	ABC-type sugar transport system, permease component
IOD14_RS11940	COG0277	FAD linked oxidase domain protein
IOD14_RS11965	COG5297	Belongs to the glycosyl hydrolase family 6
IOD14_RS11975	COG3938	Belongs to the proline racemase family
IOD14_RS11980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS11995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD14_RS12005	COG1162	GTPase activity
IOD14_RS12015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD14_RS12035	COG0028	Belongs to the TPP enzyme family
IOD14_RS12075	COG1802	Transcriptional regulator
IOD14_RS12085	COG3835	regulator
IOD14_RS12100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IOD14_RS12105	COG2252	PERMEase
IOD14_RS12110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IOD14_RS12110	COG3608	succinylglutamate desuccinylase aspartoacylase
IOD14_RS12190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD14_RS12210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD14_RS12215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IOD14_RS12245	COG1136	(ABC) transporter
IOD14_RS12280	COG2197	response regulator
IOD14_RS12285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD14_RS12290	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS12305	COG3960	tartronate-semialdehyde synthase activity
IOD14_RS12315	COG2084	Dehydrogenase
IOD14_RS12320	COG3622	Belongs to the hyi family
IOD14_RS12340	COG2351	hydroxyisourate hydrolase activity
IOD14_RS12355	COG2233	PERMEase
IOD14_RS12380	COG1733	regulation of RNA biosynthetic process
IOD14_RS12395	COG0406	alpha-ribazole phosphatase activity
IOD14_RS12410	COG0436	Aminotransferase
IOD14_RS12415	COG1733	regulation of RNA biosynthetic process
IOD14_RS12430	COG4264	IucA IucC family
IOD14_RS12460	COG0515	serine threonine protein kinase
IOD14_RS12460	COG2815	serine threonine protein kinase
IOD14_RS12480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IOD14_RS12500	COG1414	Transcriptional regulator
IOD14_RS12505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOD14_RS12510	COG4266	Belongs to the allantoicase family
IOD14_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS12535	COG2197	response regulator
IOD14_RS12545	COG0673	inositol 2-dehydrogenase activity
IOD14_RS12550	COG2188	Transcriptional regulator
IOD14_RS12555	COG1940	carbohydrate kinase activity
IOD14_RS12565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD14_RS12575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS12580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IOD14_RS12600	COG1126	abc transporter atp-binding protein
IOD14_RS12615	COG0405	Gamma-glutamyltransferase
IOD14_RS12620	COG0542	response to heat
IOD14_RS12645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD14_RS12660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOD14_RS12670	COG1953	Uracil, thiamine, allantoin
IOD14_RS12685	COG3851	Histidine kinase
IOD14_RS12690	COG2197	response regulator
IOD14_RS12695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD14_RS12710	COG0483	inositol monophosphate 1-phosphatase activity
IOD14_RS12720	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IOD14_RS12735	COG2814	Major facilitator Superfamily
IOD14_RS12740	COG0640	Transcriptional regulator
IOD14_RS12745	COG2217	Heavy metal translocating P-type atpase
IOD14_RS12770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD14_RS12775	COG0494	nUDIX hydrolase
IOD14_RS12795	COG2124	cytochrome p450
IOD14_RS12810	COG2018	Roadblock/LC7 domain
IOD14_RS12825	COG1929	Belongs to the glycerate kinase type-1 family
IOD14_RS12845	COG0559	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS12850	COG0559	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS12865	COG0688	phosphatidylethanolamine metabolic process
IOD14_RS12870	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS12885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS12885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS12890	COG0604	alcohol dehydrogenase
IOD14_RS12900	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS12945	COG2226	methyltransferase
IOD14_RS12950	COG3594	Acyltransferase
IOD14_RS12955	COG2362	D-Aminopeptidase
IOD14_RS12960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD14_RS12965	COG0823	Involved in the tonB-independent uptake of proteins
IOD14_RS12965	COG1506	peptidase
IOD14_RS12965	COG4946	Tricorn protease homolog
IOD14_RS12970	COG1619	proteins homologs of microcin C7 resistance protein MccF
IOD14_RS13010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS13020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD14_RS13025	COG3285	dna ligase
IOD14_RS13025	COG1793	dna ligase
IOD14_RS13090	COG1597	lipid kinase activity
IOD14_RS13095	COG0488	(ABC) transporter
IOD14_RS13205	COG0443	Heat shock 70 kDa protein
IOD14_RS13235	COG2154	pterin-4-alpha-carbinolamine dehydratase
IOD14_RS13240	COG2226	methyltransferase
IOD14_RS13255	COG2378	regulation of single-species biofilm formation
IOD14_RS13260	COG3401	FG-GAP repeat protein
IOD14_RS13270	COG4733	cellulase activity
IOD14_RS13270	COG5297	Belongs to the glycosyl hydrolase family 6
IOD14_RS13275	COG5297	Belongs to the glycosyl hydrolase family 6
IOD14_RS13275	COG4733	cellulase activity
IOD14_RS13280	COG5297	Belongs to the glycosyl hydrolase family 6
IOD14_RS13300	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD14_RS13300	COG2319	Wd-40 repeat
IOD14_RS13310	COG0656	L-ascorbic acid biosynthetic process
IOD14_RS13315	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IOD14_RS13330	COG3469	chitinase activity
IOD14_RS13335	COG3250	beta-galactosidase activity
IOD14_RS13365	COG1846	Transcriptional regulator
IOD14_RS13370	COG1335	isochorismatase
IOD14_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS13380	COG0583	DNA-binding transcription factor activity
IOD14_RS13385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOD14_RS13405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD14_RS13420	COG1940	carbohydrate kinase activity
IOD14_RS13425	COG1129	ABC transporter
IOD14_RS13430	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS13440	COG0673	inositol 2-dehydrogenase activity
IOD14_RS13475	COG0084	hydrolase, TatD family'
IOD14_RS13505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IOD14_RS13520	COG2223	nitrite transmembrane transporter activity
IOD14_RS13525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS13530	COG0045	succinate-CoA ligase (ADP-forming) activity
IOD14_RS13540	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS13545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS13570	COG1802	Transcriptional regulator
IOD14_RS13585	COG3383	formate dehydrogenase (NAD+) activity
IOD14_RS13595	COG0583	DNA-binding transcription factor activity
IOD14_RS13600	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS13605	COG0028	Belongs to the TPP enzyme family
IOD14_RS13610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS13625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS13630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD14_RS13650	COG0747	negative chemotaxis
IOD14_RS13655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS13670	COG1183	phosphatidylcholine synthase activity
IOD14_RS13685	COG0438	transferase activity, transferring glycosyl groups
IOD14_RS13700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD14_RS13730	COG3467	pyridoxamine 5'-phosphate
IOD14_RS13735	COG0477	Major facilitator Superfamily
IOD14_RS13745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD14_RS13755	COG0588	phosphoglycerate mutase activity
IOD14_RS13760	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IOD14_RS13765	COG0166	Belongs to the GPI family
IOD14_RS13780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD14_RS13800	COG3511	phospholipase C
IOD14_RS13820	COG2409	Drug exporters of the RND superfamily
IOD14_RS13830	COG2197	response regulator
IOD14_RS13835	COG3850	Histidine kinase
IOD14_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS13880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD14_RS13885	COG3250	beta-galactosidase activity
IOD14_RS13890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IOD14_RS13895	COG0395	ABC-type sugar transport system, permease component
IOD14_RS13910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS13915	COG1349	DNA-binding transcription factor activity
IOD14_RS13920	COG1486	melibiose metabolic process
IOD14_RS13935	COG3469	chitinase activity
IOD14_RS13945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD14_RS13985	COG1653	transport
IOD14_RS13990	COG1175	transmembrane transport
IOD14_RS13995	COG0395	ABC-type sugar transport system, permease component
IOD14_RS14000	COG0366	Alpha amylase catalytic
IOD14_RS14015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD14_RS14020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD14_RS14030	COG1414	Transcriptional regulator
IOD14_RS14060	COG1175	transmembrane transport
IOD14_RS14065	COG0395	ABC-type sugar transport system, permease component
IOD14_RS14070	COG2272	Belongs to the type-B carboxylesterase lipase family
IOD14_RS14075	COG1940	carbohydrate kinase activity
IOD14_RS14095	COG0477	Major facilitator Superfamily
IOD14_RS14100	COG3511	phospholipase C
IOD14_RS14130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOD14_RS14140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS14145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD14_RS14150	COG3485	protocatechuate 3,4-dioxygenase
IOD14_RS14155	COG3485	protocatechuate 3,4-dioxygenase
IOD14_RS14160	COG1846	Transcriptional regulator
IOD14_RS14175	COG1793	dna ligase
IOD14_RS14265	COG1834	amidinotransferase
IOD14_RS14280	COG0488	(ABC) transporter
IOD14_RS14290	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IOD14_RS14315	COG1515	deoxyribonuclease V activity
IOD14_RS14325	COG3268	Saccharopine dehydrogenase
IOD14_RS14335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS14340	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS14345	COG0183	Belongs to the thiolase family
IOD14_RS14350	COG1024	Enoyl-CoA hydratase
IOD14_RS14350	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS14360	COG1113	amino acid transport
IOD14_RS14375	COG2936	dipeptidyl-peptidase activity
IOD14_RS14385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD14_RS14395	COG0488	(ABC) transporter
IOD14_RS14410	COG4977	sequence-specific DNA binding
IOD14_RS14420	COG1024	Enoyl-CoA hydratase
IOD14_RS14430	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IOD14_RS14475	COG1388	LysM domain
IOD14_RS14475	COG1134	teichoic acid transport
IOD14_RS14480	COG1562	ergosterol biosynthetic process
IOD14_RS14490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IOD14_RS14500	COG1657	PFAM Prenyltransferase squalene oxidase
IOD14_RS14515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IOD14_RS14520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IOD14_RS14540	COG2365	Tyrosine phosphatase family
IOD14_RS14560	COG2755	lipolytic protein G-D-S-L family
IOD14_RS14605	COG1309	transcriptional regulator
IOD14_RS14615	COG0477	Major facilitator Superfamily
IOD14_RS14625	COG0583	DNA-binding transcription factor activity
IOD14_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS14645	COG0156	8-amino-7-oxononanoate synthase activity
IOD14_RS14650	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS14655	COG0477	Major facilitator Superfamily
IOD14_RS14665	COG2030	dehydratase
IOD14_RS14670	COG2030	dehydratase
IOD14_RS14675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD14_RS14690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD14_RS14700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD14_RS14710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD14_RS14720	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS14730	COG2050	protein possibly involved in aromatic compounds catabolism
IOD14_RS14740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD14_RS14745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD14_RS14750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD14_RS14755	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS14770	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD14_RS14770	COG1902	pentaerythritol trinitrate reductase activity
IOD14_RS14780	COG2197	response regulator
IOD14_RS14790	COG1063	alcohol dehydrogenase
IOD14_RS14795	COG0156	8-amino-7-oxononanoate synthase activity
IOD14_RS14800	COG0583	DNA-binding transcription factor activity
IOD14_RS14825	COG3958	Transketolase
IOD14_RS14830	COG3959	Transketolase, thiamine diphosphate binding domain
IOD14_RS14865	COG0488	(ABC) transporter
IOD14_RS14870	COG0488	(ABC) transporter
IOD14_RS14875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IOD14_RS14900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD14_RS14955	COG0174	glutamine synthetase
IOD14_RS14965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD14_RS14980	COG1396	sequence-specific DNA binding
IOD14_RS14985	COG0006	proline dipeptidase activity
IOD14_RS14990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOD14_RS14995	COG0022	dehydrogenase e1 component
IOD14_RS15000	COG0402	S-adenosylhomocysteine deaminase activity
IOD14_RS15005	COG1917	Cupin 2, conserved barrel domain protein
IOD14_RS15035	COG2267	carboxylic ester hydrolase activity
IOD14_RS15080	COG0494	nUDIX hydrolase
IOD14_RS15095	COG1086	Polysaccharide biosynthesis protein
IOD14_RS15100	COG1316	TRANSCRIPTIONal
IOD14_RS15125	COG2244	polysaccharide biosynthetic process
IOD14_RS15155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOD14_RS15160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD14_RS15185	COG3387	PFAM Glycoside hydrolase 15-related
IOD14_RS15190	COG2188	Transcriptional regulator
IOD14_RS15195	COG3962	Belongs to the TPP enzyme family
IOD14_RS15200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS15225	COG0673	inositol 2-dehydrogenase activity
IOD14_RS15240	COG0673	inositol 2-dehydrogenase activity
IOD14_RS15245	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS15260	COG0673	inositol 2-dehydrogenase activity
IOD14_RS15265	COG1609	Transcriptional regulator
IOD14_RS15290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD14_RS15295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD14_RS15310	COG2814	Major facilitator Superfamily
IOD14_RS15320	COG0477	Major facilitator Superfamily
IOD14_RS15340	COG1672	PFAM Archaeal ATPase
IOD14_RS15340	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD14_RS15365	COG1222	aaa ATPase
IOD14_RS15455	COG3387	PFAM Glycoside hydrolase 15-related
IOD14_RS15500	COG1597	lipid kinase activity
IOD14_RS15530	COG1132	(ABC) transporter
IOD14_RS15550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOD14_RS15560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOD14_RS15565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD14_RS15605	COG0463	Glycosyl transferase, family 2
IOD14_RS15635	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IOD14_RS15650	COG1063	alcohol dehydrogenase
IOD14_RS15655	COG1414	Transcriptional regulator
IOD14_RS15660	COG0129	dihydroxy-acid dehydratase activity
IOD14_RS15665	COG0435	Glutathione S-transferase
IOD14_RS15675	COG1126	abc transporter atp-binding protein
IOD14_RS15690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS15695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS15720	COG1404	Belongs to the peptidase S8 family
IOD14_RS15735	COG2124	cytochrome p450
IOD14_RS15750	COG2838	Isocitrate dehydrogenase
IOD14_RS15760	COG0668	transmembrane transport
IOD14_RS15770	COG1132	(ABC) transporter
IOD14_RS15800	COG2132	Multicopper oxidase
IOD14_RS15805	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IOD14_RS15815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IOD14_RS15835	COG0297	glycogen (starch) synthase activity
IOD14_RS15840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IOD14_RS15870	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS15905	COG1609	Transcriptional regulator
IOD14_RS15910	COG1653	transport
IOD14_RS15915	COG1175	transmembrane transport
IOD14_RS15920	COG0395	ABC-type sugar transport system, permease component
IOD14_RS15940	COG2186	Transcriptional regulator
IOD14_RS15945	COG1879	ABC-type sugar transport system periplasmic component
IOD14_RS15950	COG1129	ABC transporter
IOD14_RS15955	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS15960	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS15980	COG3618	amidohydrolase
IOD14_RS16000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD14_RS16030	COG0596	Alpha beta hydrolase
IOD14_RS16045	COG0726	polysaccharide deacetylase
IOD14_RS16090	COG0583	DNA-binding transcription factor activity
IOD14_RS16100	COG1053	succinate dehydrogenase
IOD14_RS16105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD14_RS16125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS16135	COG0523	cobalamin synthesis protein
IOD14_RS16160	COG3360	Dodecin
IOD14_RS16165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IOD14_RS16170	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IOD14_RS16175	COG0121	glutamine amidotransferase
IOD14_RS16180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOD14_RS16185	COG3572	ergothioneine biosynthetic process
IOD14_RS16205	COG2268	Band 7 protein
IOD14_RS16220	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD14_RS16225	COG5520	Belongs to the glycosyl hydrolase 30 family
IOD14_RS16250	COG2755	lipolytic protein G-D-S-L family
IOD14_RS16275	COG0281	malic enzyme
IOD14_RS16280	COG1609	Transcriptional regulator
IOD14_RS16285	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD14_RS16335	COG1595	DNA-templated transcription, initiation
IOD14_RS16345	COG3284	Transcriptional regulator
IOD14_RS16355	COG3485	protocatechuate 3,4-dioxygenase
IOD14_RS16360	COG1454	alcohol dehydrogenase
IOD14_RS16365	COG2353	YceI-like domain
IOD14_RS16380	COG0531	amino acid
IOD14_RS16385	COG1228	amidohydrolase
IOD14_RS16395	COG2197	response regulator
IOD14_RS16405	COG1609	Transcriptional regulator
IOD14_RS16415	COG1175	transmembrane transport
IOD14_RS16420	COG0395	ABC-type sugar transport system, permease component
IOD14_RS16435	COG0300	oxidoreductase activity
IOD14_RS16445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS16500	COG1609	Transcriptional regulator
IOD14_RS16515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD14_RS16525	COG0242	peptide deformylase activity
IOD14_RS16570	COG2814	Major facilitator Superfamily
IOD14_RS16575	COG0745	RESPONSE REGULATOR receiver
IOD14_RS16580	COG4770	biotin carboxylase activity
IOD14_RS16600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD14_RS16630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD14_RS16655	COG2124	cytochrome p450
IOD14_RS16700	COG1522	sequence-specific DNA binding
IOD14_RS16710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD14_RS16740	COG1295	ribonuclease BN
IOD14_RS16750	COG1609	Transcriptional regulator
IOD14_RS16755	COG1609	Transcriptional regulator
IOD14_RS16805	COG0542	response to heat
IOD14_RS16815	COG1136	(ABC) transporter
IOD14_RS16815	COG0577	efflux transmembrane transporter activity
IOD14_RS16830	COG3250	beta-galactosidase activity
IOD14_RS16835	COG1556	Lactate utilization protein
IOD14_RS16840	COG1139	Iron-sulfur cluster binding protein
IOD14_RS16845	COG0247	lactate metabolic process
IOD14_RS16850	COG1070	Carbohydrate kinase
IOD14_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS16855	COG3347	Dehydrogenase
IOD14_RS16865	COG1129	ABC transporter
IOD14_RS16870	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS16875	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS16880	COG1879	ABC-type sugar transport system periplasmic component
IOD14_RS16895	COG1609	Transcriptional regulator
IOD14_RS16915	COG1357	PFAM Pentapeptide repeats (8 copies)
IOD14_RS16925	COG1309	transcriptional regulator
IOD14_RS16935	COG2706	6-phosphogluconolactonase activity
IOD14_RS17015	COG1796	DNA polymerase
IOD14_RS17015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IOD14_RS17050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOD14_RS17060	COG1846	Transcriptional regulator
IOD14_RS17065	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS17120	COG0435	Glutathione S-transferase
IOD14_RS17135	COG2124	cytochrome p450
IOD14_RS17185	COG0667	Aldo Keto reductase
IOD14_RS17220	COG3250	beta-galactosidase activity
IOD14_RS17230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IOD14_RS17295	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD14_RS17310	COG0248	Ppx GppA phosphatase
IOD14_RS17325	COG3832	glyoxalase III activity
IOD14_RS17365	COG2197	response regulator
IOD14_RS17375	COG1132	(ABC) transporter
IOD14_RS17385	COG0515	serine threonine protein kinase
IOD14_RS17395	COG0517	IMP dehydrogenase activity
IOD14_RS17425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IOD14_RS17485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOD14_RS17510	COG0019	diaminopimelate decarboxylase activity
IOD14_RS17515	COG4264	IucA IucC family
IOD14_RS17520	COG2814	Major facilitator Superfamily
IOD14_RS17535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD14_RS17540	COG1120	ATPase activity
IOD14_RS17545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD14_RS17550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD14_RS17560	COG1132	(ABC) transporter
IOD14_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS17595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD14_RS17615	COG0395	ABC-type sugar transport system, permease component
IOD14_RS17620	COG1175	transmembrane transport
IOD14_RS17625	COG1846	Transcriptional regulator
IOD14_RS17625	COG1940	carbohydrate kinase activity
IOD14_RS17720	COG1940	carbohydrate kinase activity
IOD14_RS17735	COG0395	ABC-type sugar transport system, permease component
IOD14_RS17750	COG1072	(Pantothenic acid kinase))
IOD14_RS17780	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD14_RS17815	COG2409	Drug exporters of the RND superfamily
IOD14_RS17840	COG0673	inositol 2-dehydrogenase activity
IOD14_RS17845	COG0667	Aldo Keto reductase
IOD14_RS17875	COG1132	(ABC) transporter
IOD14_RS17950	COG2755	lipolytic protein G-D-S-L family
IOD14_RS17975	COG1846	Transcriptional regulator
IOD14_RS17990	COG3290	protein histidine kinase activity
IOD14_RS18020	COG0640	Transcriptional regulator
IOD14_RS18050	COG1473	amidohydrolase
IOD14_RS18080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS18120	COG1765	OsmC-like protein
IOD14_RS18125	COG4977	sequence-specific DNA binding
IOD14_RS18135	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS18145	COG1082	Xylose isomerase domain protein TIM barrel
IOD14_RS18185	COG1073	alpha beta
IOD14_RS18195	COG1063	alcohol dehydrogenase
IOD14_RS18230	COG0583	DNA-binding transcription factor activity
IOD14_RS18255	COG3655	Transcriptional regulator
IOD14_RS18300	COG3345	alpha-galactosidase
IOD14_RS18305	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD14_RS18325	COG2186	Transcriptional regulator
IOD14_RS18335	COG0531	amino acid
IOD14_RS18340	COG1940	carbohydrate kinase activity
IOD14_RS18355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD14_RS18370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS18375	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS18385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IOD14_RS18395	COG0583	DNA-binding transcription factor activity
IOD14_RS18415	COG0148	phosphopyruvate hydratase activity
IOD14_RS18425	COG1609	Transcriptional regulator
IOD14_RS18430	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD14_RS18435	COG2814	Major facilitator Superfamily
IOD14_RS18470	COG1733	regulation of RNA biosynthetic process
IOD14_RS18485	COG0183	Belongs to the thiolase family
IOD14_RS18500	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS18515	COG1063	alcohol dehydrogenase
IOD14_RS18525	COG1129	ABC transporter
IOD14_RS18535	COG4638	Rieske (2fe-2S)
IOD14_RS18550	COG2130	NADP-dependent
IOD14_RS18570	COG4638	Rieske (2fe-2S)
IOD14_RS18580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOD14_RS18585	COG0022	dehydrogenase e1 component
IOD14_RS18590	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD14_RS18595	COG3467	pyridoxamine 5'-phosphate
IOD14_RS18610	COG0183	Belongs to the thiolase family
IOD14_RS18620	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS18625	COG0574	Belongs to the PEP-utilizing enzyme family
IOD14_RS18625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD14_RS18635	COG1024	Enoyl-CoA hydratase
IOD14_RS18675	COG0667	Aldo Keto reductase
IOD14_RS18780	COG1595	DNA-templated transcription, initiation
IOD14_RS18785	COG0300	oxidoreductase activity
IOD14_RS18800	COG0667	Aldo Keto reductase
IOD14_RS18805	COG1309	transcriptional regulator
IOD14_RS18860	COG2197	response regulator
IOD14_RS18880	COG0395	ABC-type sugar transport system, permease component
IOD14_RS18940	COG0745	RESPONSE REGULATOR receiver
IOD14_RS18945	COG2205	protein histidine kinase activity
IOD14_RS18950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD14_RS18955	COG1011	Hydrolase
IOD14_RS18960	COG0738	Major facilitator superfamily
IOD14_RS18975	COG3220	belongs to the UPF0276 family
IOD14_RS19015	COG1136	(ABC) transporter
IOD14_RS19030	COG0673	inositol 2-dehydrogenase activity
IOD14_RS19045	COG1595	DNA-templated transcription, initiation
IOD14_RS19050	COG1252	NADH dehydrogenase
IOD14_RS19055	COG0500	methyltransferase
IOD14_RS19060	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS19085	COG0583	DNA-binding transcription factor activity
IOD14_RS19090	COG2124	cytochrome p450
IOD14_RS19095	COG3409	Peptidoglycan-binding domain 1 protein
IOD14_RS19115	COG2318	DinB family
IOD14_RS19145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOD14_RS19190	COG1940	carbohydrate kinase activity
IOD14_RS19195	COG1129	ABC transporter
IOD14_RS19200	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS19210	COG0673	inositol 2-dehydrogenase activity
IOD14_RS19245	COG2319	Wd-40 repeat
IOD14_RS19245	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD14_RS19295	COG3693	PFAM glycoside hydrolase, family 10
IOD14_RS19400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD14_RS19405	COG0247	lactate metabolic process
IOD14_RS19405	COG0277	FAD linked oxidase domain protein
IOD14_RS19415	COG1414	Transcriptional regulator
IOD14_RS19420	COG1414	Transcriptional regulator
IOD14_RS19440	COG3842	ATPase activity
IOD14_RS19455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD14_RS19460	COG3608	succinylglutamate desuccinylase aspartoacylase
IOD14_RS19465	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS19470	COG0667	Aldo Keto reductase
IOD14_RS19480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD14_RS19480	COG0723	plastoquinol--plastocyanin reductase activity
IOD14_RS19495	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS19500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOD14_RS19510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD14_RS19530	COG0640	Transcriptional regulator
IOD14_RS19585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS19590	COG1595	DNA-templated transcription, initiation
IOD14_RS19690	COG0583	DNA-binding transcription factor activity
IOD14_RS19725	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS19755	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS19765	COG3485	protocatechuate 3,4-dioxygenase
IOD14_RS19770	COG1454	alcohol dehydrogenase
IOD14_RS19800	COG1309	transcriptional regulator
IOD14_RS19850	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IOD14_RS19875	COG2508	Transcriptional regulator
IOD14_RS19885	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS19925	COG3971	2-oxopent-4-enoate hydratase activity
IOD14_RS19930	COG3485	protocatechuate 3,4-dioxygenase
IOD14_RS19950	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IOD14_RS19960	COG0187	DNA topoisomerase II activity
IOD14_RS20075	COG3469	chitinase activity
IOD14_RS20090	COG2197	response regulator
IOD14_RS20095	COG4585	Histidine kinase
IOD14_RS20105	COG1131	(ABC) transporter
IOD14_RS20110	COG2226	methyltransferase
IOD14_RS20160	COG1595	DNA-templated transcription, initiation
IOD14_RS20195	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IOD14_RS20200	COG0714	Associated with various cellular activities
IOD14_RS20220	COG4989	oxidoreductase activity
IOD14_RS20250	COG0300	oxidoreductase activity
IOD14_RS20255	COG3345	alpha-galactosidase
IOD14_RS20265	COG1175	transmembrane transport
IOD14_RS20270	COG0395	ABC-type sugar transport system, permease component
IOD14_RS20285	COG2186	Transcriptional regulator
IOD14_RS20290	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS20300	COG0800	Aldolase
IOD14_RS20385	COG0456	acetyltransferase
IOD14_RS20390	COG2318	DinB family
IOD14_RS20415	COG1902	pentaerythritol trinitrate reductase activity
IOD14_RS20440	COG1024	Enoyl-CoA hydratase
IOD14_RS20440	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS20450	COG1309	transcriptional regulator
IOD14_RS20455	COG3321	synthase
IOD14_RS20455	COG0604	alcohol dehydrogenase
IOD14_RS20470	COG1024	Enoyl-CoA hydratase
IOD14_RS20470	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS20480	COG1309	transcriptional regulator
IOD14_RS20570	COG3158	transport of potassium into the cell
IOD14_RS20585	COG0156	8-amino-7-oxononanoate synthase activity
IOD14_RS20625	COG0531	amino acid
IOD14_RS20640	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IOD14_RS20645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IOD14_RS20650	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IOD14_RS20685	COG1116	anion transmembrane transporter activity
IOD14_RS20695	COG0640	Transcriptional regulator
IOD14_RS20700	COG0598	Magnesium transport protein CorA
IOD14_RS20705	COG0598	Magnesium transport protein CorA
IOD14_RS20760	COG0494	nUDIX hydrolase
IOD14_RS20800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD14_RS20800	COG1473	amidohydrolase
IOD14_RS20835	COG3321	synthase
IOD14_RS20835	COG0604	alcohol dehydrogenase
IOD14_RS20860	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS20895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS20915	COG0154	amidase activity
IOD14_RS20925	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS20995	COG1506	peptidase
IOD14_RS20995	COG0823	Involved in the tonB-independent uptake of proteins
IOD14_RS21010	COG2197	response regulator
IOD14_RS21015	COG4585	Histidine kinase
IOD14_RS21045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOD14_RS21050	COG3835	regulator
IOD14_RS21060	COG0443	Heat shock 70 kDa protein
IOD14_RS21065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IOD14_RS21080	COG0542	response to heat
IOD14_RS21095	COG3634	alkyl hydroperoxide reductase activity
IOD14_RS21125	COG1349	DNA-binding transcription factor activity
IOD14_RS21140	COG0673	inositol 2-dehydrogenase activity
IOD14_RS21145	COG1609	Transcriptional regulator
IOD14_RS21150	COG2409	Drug exporters of the RND superfamily
IOD14_RS21155	COG4585	Histidine kinase
IOD14_RS21160	COG2197	response regulator
IOD14_RS21170	COG1082	Xylose isomerase domain protein TIM barrel
IOD14_RS21175	COG0673	inositol 2-dehydrogenase activity
IOD14_RS21180	COG2814	Major facilitator Superfamily
IOD14_RS21185	COG1082	Xylose isomerase domain protein TIM barrel
IOD14_RS21195	COG3962	Belongs to the TPP enzyme family
IOD14_RS21200	COG3718	enzyme involved in inositol metabolism
IOD14_RS21210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS21215	COG1609	Transcriptional regulator
IOD14_RS21220	COG0673	inositol 2-dehydrogenase activity
IOD14_RS21225	COG0673	inositol 2-dehydrogenase activity
IOD14_RS21250	COG1309	transcriptional regulator
IOD14_RS21265	COG2814	Major facilitator Superfamily
IOD14_RS21270	COG1309	transcriptional regulator
IOD14_RS21290	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS21295	COG2508	Transcriptional regulator
IOD14_RS21325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS21330	COG4172	Belongs to the ABC transporter superfamily
IOD14_RS21335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS21355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS21360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS21365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS21370	COG2175	clavaminate synthase activity
IOD14_RS21400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS21405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS21410	COG2130	NADP-dependent
IOD14_RS21415	COG0583	DNA-binding transcription factor activity
IOD14_RS21440	COG0745	RESPONSE REGULATOR receiver
IOD14_RS21460	COG1174	glycine betaine transport
IOD14_RS21480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IOD14_RS21485	COG1802	Transcriptional regulator
IOD14_RS21490	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD14_RS21495	COG2986	histidine ammonia-lyase
IOD14_RS21505	COG0789	Transcriptional regulator
IOD14_RS21510	COG2130	NADP-dependent
IOD14_RS21650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS21660	COG2755	lipolytic protein G-D-S-L family
IOD14_RS21680	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS21715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IOD14_RS21720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IOD14_RS21725	COG2080	2 iron, 2 sulfur cluster binding
IOD14_RS21780	COG2182	Extracellular solute-binding protein
IOD14_RS21785	COG1175	transmembrane transport
IOD14_RS21790	COG0395	ABC-type sugar transport system, permease component
IOD14_RS21820	COG0402	S-adenosylhomocysteine deaminase activity
IOD14_RS21835	COG1063	alcohol dehydrogenase
IOD14_RS21845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS21900	COG2409	Drug exporters of the RND superfamily
IOD14_RS21905	COG2205	protein histidine kinase activity
IOD14_RS21910	COG0745	RESPONSE REGULATOR receiver
IOD14_RS21945	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS21950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD14_RS21955	COG0765	amino acid transport
IOD14_RS21960	COG1126	abc transporter atp-binding protein
IOD14_RS21980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD14_RS22000	COG0251	oxidation-reduction process
IOD14_RS22005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD14_RS22025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD14_RS22050	COG2072	flavoprotein involved in K transport
IOD14_RS22065	COG0739	heme binding
IOD14_RS22070	COG0515	serine threonine protein kinase
IOD14_RS22080	COG1414	Transcriptional regulator
IOD14_RS22085	COG3971	2-oxopent-4-enoate hydratase activity
IOD14_RS22095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD14_RS22115	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS22120	COG0039	L-malate dehydrogenase activity
IOD14_RS22130	COG1414	Transcriptional regulator
IOD14_RS22135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD14_RS22150	COG1137	ATPase activity
IOD14_RS22170	COG0604	alcohol dehydrogenase
IOD14_RS22200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS22205	COG1024	Enoyl-CoA hydratase
IOD14_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS22220	COG2267	carboxylic ester hydrolase activity
IOD14_RS22245	COG3384	dioxygenase
IOD14_RS22255	COG0492	ferredoxin-NADP+ reductase activity
IOD14_RS22265	COG3971	2-oxopent-4-enoate hydratase activity
IOD14_RS22285	COG2046	Belongs to the sulfate adenylyltransferase family
IOD14_RS22285	COG0529	Catalyzes the synthesis of activated sulfate
IOD14_RS22295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOD14_RS22300	COG5297	Belongs to the glycosyl hydrolase family 6
IOD14_RS22305	COG5297	Belongs to the glycosyl hydrolase family 6
IOD14_RS22305	COG4733	cellulase activity
IOD14_RS22335	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS22375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD14_RS22420	COG0577	efflux transmembrane transporter activity
IOD14_RS22420	COG1136	(ABC) transporter
IOD14_RS22480	COG2326	polyphosphate kinase activity
IOD14_RS22490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS22500	COG1595	DNA-templated transcription, initiation
IOD14_RS22540	COG0596	Alpha beta hydrolase
IOD14_RS22610	COG0789	Transcriptional regulator
IOD14_RS22635	COG2272	Belongs to the type-B carboxylesterase lipase family
IOD14_RS22700	COG2272	Belongs to the type-B carboxylesterase lipase family
IOD14_RS22705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IOD14_RS22775	COG0745	RESPONSE REGULATOR receiver
IOD14_RS22795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD14_RS22810	COG2920	part of a sulfur-relay system
IOD14_RS22815	COG1252	NADH dehydrogenase
IOD14_RS22830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD14_RS22835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD14_RS22840	COG1937	Protein conserved in bacteria
IOD14_RS22845	COG0730	response to heat
IOD14_RS22850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD14_RS22855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD14_RS22855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD14_RS22870	COG0205	6-phosphofructokinase activity
IOD14_RS22875	COG1830	Aldolase
IOD14_RS22940	COG1309	transcriptional regulator
IOD14_RS22955	COG1846	Transcriptional regulator
IOD14_RS22975	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD14_RS22990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD14_RS23035	COG0604	alcohol dehydrogenase
IOD14_RS23050	COG1609	Transcriptional regulator
IOD14_RS23120	COG2814	Major facilitator Superfamily
IOD14_RS23125	COG3903	Transcriptional regulator
IOD14_RS23125	COG3629	intracellular signal transduction
IOD14_RS23140	COG3345	alpha-galactosidase
IOD14_RS23145	COG1609	Transcriptional regulator
IOD14_RS23155	COG1175	transmembrane transport
IOD14_RS23160	COG0395	ABC-type sugar transport system, permease component
IOD14_RS23175	COG2186	Transcriptional regulator
IOD14_RS23185	COG1175	transmembrane transport
IOD14_RS23190	COG0395	ABC-type sugar transport system, permease component
IOD14_RS23205	COG3618	amidohydrolase
IOD14_RS23210	COG1063	alcohol dehydrogenase
IOD14_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS23220	COG0800	Aldolase
IOD14_RS23240	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD14_RS23255	COG1606	tRNA processing
IOD14_RS23260	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IOD14_RS23265	COG1691	(AIR) carboxylase
IOD14_RS23270	COG3875	lactate racemase activity
IOD14_RS23285	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD14_RS23295	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS23300	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS23310	COG1129	ABC transporter
IOD14_RS23315	COG4214	carbohydrate transport
IOD14_RS23335	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD14_RS23345	COG1609	Transcriptional regulator
IOD14_RS23355	COG4977	sequence-specific DNA binding
IOD14_RS23390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD14_RS23405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD14_RS23440	COG0583	DNA-binding transcription factor activity
IOD14_RS23445	COG0183	Belongs to the thiolase family
IOD14_RS23455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD14_RS23515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD14_RS23525	COG2197	response regulator
IOD14_RS23530	COG4585	Histidine kinase
IOD14_RS23555	COG0640	Transcriptional regulator
IOD14_RS23565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOD14_RS23585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD14_RS23640	COG2226	methyltransferase
IOD14_RS23645	COG1011	Hydrolase
IOD14_RS23650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOD14_RS23660	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD14_RS23665	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IOD14_RS23670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IOD14_RS23675	COG0456	acetyltransferase
IOD14_RS23685	COG0076	glutamate decarboxylase activity
IOD14_RS23725	COG0583	DNA-binding transcription factor activity
IOD14_RS23730	COG1191	sigma factor activity
IOD14_RS23800	COG2329	Antibiotic biosynthesis monooxygenase
IOD14_RS23825	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD14_RS23830	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD14_RS23835	COG2172	sigma factor antagonist activity
IOD14_RS23860	COG3848	Pyruvate phosphate dikinase
IOD14_RS23860	COG0574	Belongs to the PEP-utilizing enzyme family
IOD14_RS23870	COG2208	phosphoserine phosphatase activity
IOD14_RS23870	COG2770	Histidine kinase
IOD14_RS23875	COG0596	Alpha beta hydrolase
IOD14_RS23880	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IOD14_RS23900	COG0142	geranyltranstransferase activity
IOD14_RS23920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD14_RS23930	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS23960	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD14_RS23965	COG5002	protein histidine kinase activity
IOD14_RS23965	COG2205	protein histidine kinase activity
IOD14_RS23965	COG0784	Response regulator, receiver
IOD14_RS23975	COG1982	Orn Lys Arg decarboxylase major
IOD14_RS23985	COG0367	asparagine synthase
IOD14_RS23990	COG2308	Evidence 4 Homologs of previously reported genes of
IOD14_RS23990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD14_RS24010	COG1597	lipid kinase activity
IOD14_RS24015	COG0753	catalase activity
IOD14_RS24060	COG0789	Transcriptional regulator
IOD14_RS24065	COG0784	Response regulator, receiver
IOD14_RS24070	COG4251	negative regulation of phosphorylation
IOD14_RS24095	COG0667	Aldo Keto reductase
IOD14_RS24105	COG2378	regulation of single-species biofilm formation
IOD14_RS24110	COG3903	Transcriptional regulator
IOD14_RS24110	COG3629	intracellular signal transduction
IOD14_RS24200	COG4585	Histidine kinase
IOD14_RS24205	COG2409	Drug exporters of the RND superfamily
IOD14_RS24210	COG1940	carbohydrate kinase activity
IOD14_RS24215	COG1653	transport
IOD14_RS24225	COG3833	ABC-type maltose transport systems, permease component
IOD14_RS24275	COG2124	cytochrome p450
IOD14_RS24280	COG2353	YceI-like domain
IOD14_RS24285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD14_RS24295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD14_RS24300	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS24305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD14_RS24305	COG3321	synthase
IOD14_RS24340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IOD14_RS24350	COG1136	(ABC) transporter
IOD14_RS24350	COG0577	efflux transmembrane transporter activity
IOD14_RS24355	COG4585	Histidine kinase
IOD14_RS24360	COG2197	response regulator
IOD14_RS24410	COG0009	L-threonylcarbamoyladenylate synthase
IOD14_RS24425	COG0513	Belongs to the DEAD box helicase family
IOD14_RS24445	COG2045	Belongs to the ComB family
IOD14_RS24450	COG2267	carboxylic ester hydrolase activity
IOD14_RS24455	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS24460	COG3300	MHYT domain
IOD14_RS24460	COG5001	Diguanylate cyclase
IOD14_RS24480	COG1621	beta-fructofuranosidase activity
IOD14_RS24490	COG1175	transmembrane transport
IOD14_RS24495	COG0395	ABC-type sugar transport system, permease component
IOD14_RS24500	COG1621	beta-fructofuranosidase activity
IOD14_RS24505	COG1609	Transcriptional regulator
IOD14_RS24510	COG0656	L-ascorbic acid biosynthetic process
IOD14_RS24565	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS24570	COG1793	dna ligase
IOD14_RS24590	COG2814	Major facilitator Superfamily
IOD14_RS24605	COG0181	hydroxymethylbilane synthase activity
IOD14_RS24615	COG0842	Transport permease protein
IOD14_RS24660	COG0366	Alpha amylase catalytic
IOD14_RS24675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IOD14_RS24680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IOD14_RS24700	COG1252	NADH dehydrogenase
IOD14_RS24775	COG5002	protein histidine kinase activity
IOD14_RS24795	COG3189	MarR family transcriptional regulator
IOD14_RS24815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD14_RS24835	COG0492	ferredoxin-NADP+ reductase activity
IOD14_RS24850	COG1672	PFAM Archaeal ATPase
IOD14_RS24850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IOD14_RS24865	COG3345	alpha-galactosidase
IOD14_RS24870	COG1940	carbohydrate kinase activity
IOD14_RS24870	COG1846	Transcriptional regulator
IOD14_RS24880	COG2340	Cysteine-rich secretory protein family
IOD14_RS24895	COG0142	geranyltranstransferase activity
IOD14_RS24900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD14_RS24905	COG0515	serine threonine protein kinase
IOD14_RS24905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS24930	COG3647	Membrane
IOD14_RS24940	COG0667	Aldo Keto reductase
IOD14_RS24955	COG0477	Major facilitator Superfamily
IOD14_RS24970	COG2304	oxidoreductase activity
IOD14_RS24980	COG0328	RNA-DNA hybrid ribonuclease activity
IOD14_RS25000	COG0745	RESPONSE REGULATOR receiver
IOD14_RS25020	COG0596	Alpha beta hydrolase
IOD14_RS25025	COG0740	serine-type endopeptidase activity
IOD14_RS25030	COG0740	serine-type endopeptidase activity
IOD14_RS25035	COG1396	sequence-specific DNA binding
IOD14_RS25045	COG1191	sigma factor activity
IOD14_RS25080	COG1716	ATPase activity
IOD14_RS25080	COG1131	(ABC) transporter
IOD14_RS25080	COG0842	Transport permease protein
IOD14_RS25100	COG0667	Aldo Keto reductase
IOD14_RS25105	COG0583	DNA-binding transcription factor activity
IOD14_RS25120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD14_RS25125	COG0346	lactoylglutathione lyase activity
IOD14_RS25135	COG0667	Aldo Keto reductase
IOD14_RS25140	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IOD14_RS25140	COG1082	Xylose isomerase domain protein TIM barrel
IOD14_RS25145	COG1063	alcohol dehydrogenase
IOD14_RS25150	COG0477	Major facilitator Superfamily
IOD14_RS25165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOD14_RS25185	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS25190	COG4941	Belongs to the sigma-70 factor family
IOD14_RS25205	COG2267	carboxylic ester hydrolase activity
IOD14_RS25220	COG0431	NADPH-dependent FMN reductase
IOD14_RS25235	COG0583	DNA-binding transcription factor activity
IOD14_RS25245	COG2409	Drug exporters of the RND superfamily
IOD14_RS25250	COG1846	Transcriptional regulator
IOD14_RS25255	COG0702	epimerase
IOD14_RS25305	COG0456	acetyltransferase
IOD14_RS25390	COG4249	Peptidase C14 caspase catalytic subunit p20
IOD14_RS25390	COG2319	Wd-40 repeat
IOD14_RS25435	COG1024	Enoyl-CoA hydratase
IOD14_RS25465	COG1733	regulation of RNA biosynthetic process
IOD14_RS25470	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS25475	COG2366	antibiotic biosynthetic process
IOD14_RS25485	COG2070	2-Nitropropane dioxygenase
IOD14_RS25490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS25500	COG2815	serine threonine protein kinase
IOD14_RS25500	COG0515	serine threonine protein kinase
IOD14_RS25510	COG2205	protein histidine kinase activity
IOD14_RS25515	COG0745	RESPONSE REGULATOR receiver
IOD14_RS25520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IOD14_RS25530	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS25550	COG0672	)-iron permease
IOD14_RS25560	COG1473	amidohydrolase
IOD14_RS25575	COG2376	Dihydroxyacetone kinase
IOD14_RS25580	COG1461	Dihydroxyacetone kinase
IOD14_RS25610	COG1902	pentaerythritol trinitrate reductase activity
IOD14_RS25610	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD14_RS25635	COG0475	glutathione-regulated potassium exporter activity
IOD14_RS25650	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD14_RS25670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IOD14_RS25685	COG3458	cephalosporin-C deacetylase activity
IOD14_RS25690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS25700	COG2226	methyltransferase
IOD14_RS25705	COG4941	Belongs to the sigma-70 factor family
IOD14_RS25715	COG3795	YCII-related domain
IOD14_RS25725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOD14_RS25735	COG1126	abc transporter atp-binding protein
IOD14_RS25740	COG0765	amino acid transport
IOD14_RS25745	COG0765	amino acid transport
IOD14_RS25775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IOD14_RS25780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOD14_RS25790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD14_RS25805	COG1113	amino acid transport
IOD14_RS25810	COG2186	Transcriptional regulator
IOD14_RS25815	COG1968	undecaprenyl-diphosphatase activity
IOD14_RS25820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD14_RS25825	COG1993	acr, cog1993
IOD14_RS25830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD14_RS25860	COG1846	Transcriptional regulator
IOD14_RS25890	COG0667	Aldo Keto reductase
IOD14_RS25910	COG2409	Drug exporters of the RND superfamily
IOD14_RS25920	COG2197	response regulator
IOD14_RS25930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD14_RS25935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS25950	COG1129	ABC transporter
IOD14_RS25960	COG2197	response regulator
IOD14_RS25965	COG0574	Belongs to the PEP-utilizing enzyme family
IOD14_RS25965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD14_RS25980	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOD14_RS26015	COG0516	GMP reductase activity
IOD14_RS26015	COG0517	IMP dehydrogenase activity
IOD14_RS26020	COG0409	Hydrogenase expression formation protein
IOD14_RS26025	COG0309	Hydrogenase expression formation protein (HypE)
IOD14_RS26040	COG0517	IMP dehydrogenase activity
IOD14_RS26040	COG0516	GMP reductase activity
IOD14_RS26060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IOD14_RS26080	COG1131	(ABC) transporter
IOD14_RS26095	COG0549	Belongs to the carbamate kinase family
IOD14_RS26100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IOD14_RS26110	COG0531	amino acid
IOD14_RS26135	COG0517	IMP dehydrogenase activity
IOD14_RS26135	COG0516	GMP reductase activity
IOD14_RS26150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IOD14_RS26190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IOD14_RS26195	COG0674	pyruvate-flavodoxin oxidoreductase activity
IOD14_RS26200	COG1013	pyruvate-flavodoxin oxidoreductase activity
IOD14_RS26205	COG0493	'glutamate synthase
IOD14_RS26215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOD14_RS26235	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS26250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD14_RS26270	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IOD14_RS26275	COG0589	response to stress
IOD14_RS26290	COG1063	alcohol dehydrogenase
IOD14_RS26315	COG1394	ATPase activity, coupled to movement of substances
IOD14_RS26320	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
IOD14_RS26325	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IOD14_RS26345	COG1269	ATP hydrolysis coupled proton transport
IOD14_RS26365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IOD14_RS26370	COG0569	domain protein
IOD14_RS26385	COG1335	isochorismatase
IOD14_RS26435	COG3842	ATPase activity
IOD14_RS26455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD14_RS26455	COG1017	nitric oxide dioxygenase activity
IOD14_RS26470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD14_RS26515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD14_RS26520	COG1316	TRANSCRIPTIONal
IOD14_RS26525	COG0640	Transcriptional regulator
IOD14_RS26555	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS26585	COG0463	Glycosyl transferase, family 2
IOD14_RS26600	COG0633	Ferredoxin
IOD14_RS26600	COG3217	Mosc domain protein beta barrel domain protein
IOD14_RS26620	COG1349	DNA-binding transcription factor activity
IOD14_RS26645	COG0577	efflux transmembrane transporter activity
IOD14_RS26650	COG0577	efflux transmembrane transporter activity
IOD14_RS26650	COG1136	(ABC) transporter
IOD14_RS26685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOD14_RS26710	COG1940	carbohydrate kinase activity
IOD14_RS26720	COG2813	Specifically methylates the guanine in position
IOD14_RS26725	COG2226	methyltransferase
IOD14_RS26730	COG0191	fructose-bisphosphate aldolase activity
IOD14_RS26735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD14_RS26740	COG1349	DNA-binding transcription factor activity
IOD14_RS26745	COG3387	PFAM Glycoside hydrolase 15-related
IOD14_RS26750	COG0384	phenazine biosynthesis protein PhzF
IOD14_RS26770	COG0395	ABC-type sugar transport system, permease component
IOD14_RS26775	COG1175	transmembrane transport
IOD14_RS26780	COG1653	transport
IOD14_RS26795	COG0673	inositol 2-dehydrogenase activity
IOD14_RS26815	COG2197	response regulator
IOD14_RS26845	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IOD14_RS26870	COG1609	Transcriptional regulator
IOD14_RS26880	COG2814	Major facilitator Superfamily
IOD14_RS26890	COG2186	Transcriptional regulator
IOD14_RS26895	COG2267	carboxylic ester hydrolase activity
IOD14_RS26905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS26915	COG0444	Belongs to the ABC transporter superfamily
IOD14_RS26920	COG4608	Belongs to the ABC transporter superfamily
IOD14_RS26925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS26940	COG1609	Transcriptional regulator
IOD14_RS26955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS26955	COG1703	isobutyryl-CoA mutase activity
IOD14_RS26955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IOD14_RS26965	COG2207	Transcriptional regulator
IOD14_RS26970	COG0667	Aldo Keto reductase
IOD14_RS26975	COG2409	Drug exporters of the RND superfamily
IOD14_RS27005	COG1653	transport
IOD14_RS27020	COG0515	serine threonine protein kinase
IOD14_RS27020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS27035	COG0673	inositol 2-dehydrogenase activity
IOD14_RS27045	COG1501	Belongs to the glycosyl hydrolase 31 family
IOD14_RS27050	COG0395	ABC-type sugar transport system, permease component
IOD14_RS27070	COG2208	phosphoserine phosphatase activity
IOD14_RS27085	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS27090	COG2610	gluconate transmembrane transporter activity
IOD14_RS27105	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS27115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD14_RS27145	COG1024	Enoyl-CoA hydratase
IOD14_RS27150	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS27155	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS27160	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS27170	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS27175	COG0183	Belongs to the thiolase family
IOD14_RS27190	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS27195	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS27220	COG2223	nitrite transmembrane transporter activity
IOD14_RS27275	COG2197	response regulator
IOD14_RS27280	COG4585	Histidine kinase
IOD14_RS27295	COG0445	tRNA wobble uridine modification
IOD14_RS27310	COG4608	Belongs to the ABC transporter superfamily
IOD14_RS27315	COG0444	Belongs to the ABC transporter superfamily
IOD14_RS27320	COG0601	transmembrane transport
IOD14_RS27325	COG0747	negative chemotaxis
IOD14_RS27330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD14_RS27335	COG1660	Displays ATPase and GTPase activities
IOD14_RS27345	COG3345	alpha-galactosidase
IOD14_RS27365	COG0515	serine threonine protein kinase
IOD14_RS27380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IOD14_RS27405	COG0204	Acyl-transferase
IOD14_RS27440	COG0584	glycerophosphoryl diester phosphodiesterase
IOD14_RS27490	COG1309	transcriptional regulator
IOD14_RS27520	COG0640	Transcriptional regulator
IOD14_RS27525	COG1902	pentaerythritol trinitrate reductase activity
IOD14_RS27530	COG3509	depolymerase
IOD14_RS27550	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS27570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IOD14_RS27575	COG2971	BadF BadG BcrA BcrD
IOD14_RS27585	COG2706	6-phosphogluconolactonase activity
IOD14_RS27600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD14_RS27610	COG2197	response regulator
IOD14_RS27650	COG1653	transport
IOD14_RS27655	COG1175	transmembrane transport
IOD14_RS27660	COG0395	ABC-type sugar transport system, permease component
IOD14_RS27665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS27670	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS27715	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IOD14_RS27735	COG0789	Transcriptional regulator
IOD14_RS27745	COG0438	transferase activity, transferring glycosyl groups
IOD14_RS27755	COG2124	cytochrome p450
IOD14_RS27770	COG0714	Associated with various cellular activities
IOD14_RS27790	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IOD14_RS27800	COG1609	Transcriptional regulator
IOD14_RS27800	COG2207	Transcriptional regulator
IOD14_RS27835	COG2205	protein histidine kinase activity
IOD14_RS27840	COG0745	RESPONSE REGULATOR receiver
IOD14_RS27850	COG1404	Belongs to the peptidase S8 family
IOD14_RS27870	COG0432	Pfam Uncharacterised protein family UPF0047
IOD14_RS27875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD14_RS27880	COG1116	anion transmembrane transporter activity
IOD14_RS27900	COG1132	(ABC) transporter
IOD14_RS27910	COG1301	dicarboxylic acid transport
IOD14_RS27925	COG1132	(ABC) transporter
IOD14_RS27930	COG1132	(ABC) transporter
IOD14_RS27940	COG0254	rRNA binding
IOD14_RS27955	COG1946	Acyl-CoA thioesterase
IOD14_RS27965	COG2018	Roadblock/LC7 domain
IOD14_RS28040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD14_RS28060	COG1309	transcriptional regulator
IOD14_RS28085	COG1940	carbohydrate kinase activity
IOD14_RS28105	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS28120	COG0309	Hydrogenase expression formation protein (HypE)
IOD14_RS28125	COG0409	Hydrogenase expression formation protein
IOD14_RS28130	COG0298	carbon dioxide binding
IOD14_RS28135	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOD14_RS28140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD14_RS28145	COG0375	protein maturation
IOD14_RS28185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IOD14_RS28185	COG1024	Enoyl-CoA hydratase
IOD14_RS28200	COG1408	metallophosphoesterase
IOD14_RS28205	COG0800	Aldolase
IOD14_RS28220	COG0326	Molecular chaperone. Has ATPase activity
IOD14_RS28230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IOD14_RS28235	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS28240	COG0519	Catalyzes the synthesis of GMP from XMP
IOD14_RS28240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD14_RS28250	COG1309	transcriptional regulator
IOD14_RS28255	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD14_RS28270	COG4689	acetoacetate decarboxylase
IOD14_RS28285	COG0174	glutamine synthetase
IOD14_RS28310	COG2182	Extracellular solute-binding protein
IOD14_RS28345	COG1414	Transcriptional regulator
IOD14_RS28360	COG4176	ABC-type proline glycine betaine transport system permease component
IOD14_RS28365	COG0517	IMP dehydrogenase activity
IOD14_RS28365	COG4175	Glycine betaine
IOD14_RS28370	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS28375	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IOD14_RS28385	COG4638	Rieske (2fe-2S)
IOD14_RS28390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD14_RS28395	COG2146	nitrite reductase [NAD(P)H] activity
IOD14_RS28405	COG4191	Histidine kinase
IOD14_RS28410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD14_RS28460	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS28465	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS28490	COG0077	Prephenate dehydratase
IOD14_RS28490	COG1605	Chorismate mutase
IOD14_RS28505	COG3634	alkyl hydroperoxide reductase activity
IOD14_RS28510	COG1793	dna ligase
IOD14_RS28530	COG3424	synthase
IOD14_RS28535	COG2124	cytochrome p450
IOD14_RS28545	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS28555	COG0242	peptide deformylase activity
IOD14_RS28565	COG3442	glutamine amidotransferase
IOD14_RS28570	COG0205	6-phosphofructokinase activity
IOD14_RS28585	COG0515	serine threonine protein kinase
IOD14_RS28585	COG2815	serine threonine protein kinase
IOD14_RS28595	COG3275	phosphorelay sensor kinase activity
IOD14_RS28600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD14_RS28610	COG3279	Response regulator of the LytR AlgR family
IOD14_RS28615	COG1522	sequence-specific DNA binding
IOD14_RS28620	COG1834	amidinotransferase
IOD14_RS28625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD14_RS28655	COG0829	nickel cation binding
IOD14_RS28660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD14_RS28670	COG0804	urea catabolic process
IOD14_RS28675	COG0832	Belongs to the urease beta subunit family
IOD14_RS28680	COG0831	urea catabolic process
IOD14_RS28685	COG1309	transcriptional regulator
IOD14_RS28700	COG0740	serine-type endopeptidase activity
IOD14_RS28735	COG0156	8-amino-7-oxononanoate synthase activity
IOD14_RS28740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOD14_RS28745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD14_RS28750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD14_RS28760	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IOD14_RS28765	COG2226	methyltransferase
IOD14_RS28780	COG1136	(ABC) transporter
IOD14_RS28785	COG1136	(ABC) transporter
IOD14_RS28785	COG0577	efflux transmembrane transporter activity
IOD14_RS28795	COG0456	acetyltransferase
IOD14_RS28820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD14_RS28825	COG3663	DNA glycosylase
IOD14_RS28845	COG4585	Histidine kinase
IOD14_RS28850	COG2197	response regulator
IOD14_RS28855	COG1940	carbohydrate kinase activity
IOD14_RS28860	COG2188	Transcriptional regulator
IOD14_RS28865	COG1595	DNA-templated transcription, initiation
IOD14_RS28870	COG0596	Alpha beta hydrolase
IOD14_RS28880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD14_RS28895	COG0626	cystathionine gamma-synthase activity
IOD14_RS28920	COG1522	sequence-specific DNA binding
IOD14_RS28925	COG0419	ATPase involved in DNA repair
IOD14_RS28930	COG0420	3'-5' exonuclease activity
IOD14_RS28935	COG1739	Uncharacterized protein family UPF0029
IOD14_RS28960	COG0589	response to stress
IOD14_RS28975	COG2326	polyphosphate kinase activity
IOD14_RS28985	COG1832	CoA-binding protein
IOD14_RS28990	COG0531	amino acid
IOD14_RS29000	COG0640	Transcriptional regulator
IOD14_RS29025	COG0110	maltose O-acetyltransferase activity
IOD14_RS29045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD14_RS29065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD14_RS29075	COG0183	Belongs to the thiolase family
IOD14_RS29085	COG1968	undecaprenyl-diphosphatase activity
IOD14_RS29095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD14_RS29105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IOD14_RS29115	COG2318	DinB family
IOD14_RS29130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IOD14_RS29135	COG4166	transmembrane transport
IOD14_RS29235	COG0657	acetylesterase activity
IOD14_RS29270	COG1609	Transcriptional regulator
IOD14_RS29280	COG0395	ABC-type sugar transport system, permease component
IOD14_RS29285	COG1175	transmembrane transport
IOD14_RS29315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IOD14_RS29315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IOD14_RS29325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD14_RS29345	COG1716	ATPase activity
IOD14_RS29365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IOD14_RS29395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD14_RS29410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD14_RS29415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD14_RS29435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD14_RS29440	COG3706	GGDEF domain
IOD14_RS29445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD14_RS29450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD14_RS29505	COG2814	Major facilitator Superfamily
IOD14_RS29510	COG4336	lyase activity
IOD14_RS29515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IOD14_RS29520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IOD14_RS29525	COG1984	allophanate hydrolase subunit 2
IOD14_RS29530	COG2755	lipolytic protein G-D-S-L family
IOD14_RS29535	COG0438	transferase activity, transferring glycosyl groups
IOD14_RS29570	COG2364	Membrane
IOD14_RS29580	COG2270	Major facilitator Superfamily
IOD14_RS29595	COG1216	Glycosyl transferase, family 2
IOD14_RS29625	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS29675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOD14_RS29680	COG0140	phosphoribosyl-ATP diphosphatase activity
IOD14_RS29685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IOD14_RS29690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD14_RS29690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD14_RS29695	COG3201	nicotinamide mononucleotide transporter
IOD14_RS29705	COG1940	carbohydrate kinase activity
IOD14_RS29705	COG1846	Transcriptional regulator
IOD14_RS29710	COG0738	Major facilitator superfamily
IOD14_RS29735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD14_RS29745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD14_RS29755	COG3842	ATPase activity
IOD14_RS29775	COG2188	Transcriptional regulator
IOD14_RS29790	COG0531	amino acid
IOD14_RS29815	COG2390	Transcriptional regulator
IOD14_RS29820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD14_RS29825	COG2409	Drug exporters of the RND superfamily
IOD14_RS29835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IOD14_RS29850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IOD14_RS29860	COG1758	RNA polymerase activity
IOD14_RS29865	COG0194	GDP metabolic process
IOD14_RS29875	COG0284	orotidine-5'-phosphate decarboxylase activity
IOD14_RS29880	COG0167	dihydroorotate dehydrogenase activity
IOD14_RS29885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IOD14_RS29890	COG0505	Belongs to the CarA family
IOD14_RS29900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOD14_RS29905	COG0540	Belongs to the ATCase OTCase family
IOD14_RS29910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IOD14_RS29925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IOD14_RS29930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IOD14_RS29935	COG0006	proline dipeptidase activity
IOD14_RS29945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IOD14_RS29950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD14_RS29955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IOD14_RS29960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD14_RS29965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOD14_RS29970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOD14_RS29975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IOD14_RS29995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IOD14_RS30010	COG1131	(ABC) transporter
IOD14_RS30020	COG4585	Histidine kinase
IOD14_RS30025	COG2197	response regulator
IOD14_RS30035	COG0124	histidyl-tRNA synthetase
IOD14_RS30045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD14_RS30050	COG1196	nuclear chromosome segregation
IOD14_RS30055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD14_RS30060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD14_RS30065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD14_RS30070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD14_RS30080	COG2255	four-way junction helicase activity
IOD14_RS30085	COG0632	four-way junction helicase activity
IOD14_RS30090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IOD14_RS30095	COG0217	transcriptional regulatory protein
IOD14_RS30100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IOD14_RS30105	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IOD14_RS30115	COG0438	transferase activity, transferring glycosyl groups
IOD14_RS30120	COG1560	Kdo2-lipid A biosynthetic process
IOD14_RS30125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOD14_RS30145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD14_RS30150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IOD14_RS30165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD14_RS30195	COG0395	ABC-type sugar transport system, permease component
IOD14_RS30200	COG1175	transmembrane transport
IOD14_RS30205	COG1653	transport
IOD14_RS30255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD14_RS30315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IOD14_RS30315	COG1648	precorrin-2 dehydrogenase activity
IOD14_RS30320	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IOD14_RS30335	COG1464	Belongs to the NlpA lipoprotein family
IOD14_RS30340	COG2011	ABC-type metal ion transport system permease component
IOD14_RS30345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD14_RS30375	COG0584	glycerophosphoryl diester phosphodiesterase
IOD14_RS30385	COG0477	Major facilitator Superfamily
IOD14_RS30400	COG0165	Argininosuccinate lyase
IOD14_RS30415	COG2205	protein histidine kinase activity
IOD14_RS30420	COG0745	RESPONSE REGULATOR receiver
IOD14_RS30450	COG1438	arginine binding
IOD14_RS30455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD14_RS30460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD14_RS30465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IOD14_RS30470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IOD14_RS30510	COG0697	spore germination
IOD14_RS30520	COG1649	PFAM Uncharacterised BCR, COG1649
IOD14_RS30550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD14_RS30550	COG0072	phenylalanine-tRNA ligase activity
IOD14_RS30555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IOD14_RS30560	COG5002	protein histidine kinase activity
IOD14_RS30565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD14_RS30570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IOD14_RS30575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IOD14_RS30580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IOD14_RS30630	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS30635	COG0174	glutamine synthetase
IOD14_RS30645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IOD14_RS30660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD14_RS30670	COG4176	ABC-type proline glycine betaine transport system permease component
IOD14_RS30675	COG4175	Glycine betaine
IOD14_RS30675	COG0517	IMP dehydrogenase activity
IOD14_RS30680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD14_RS30710	COG2124	cytochrome p450
IOD14_RS30785	COG0805	protein transport
IOD14_RS30790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD14_RS30820	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD14_RS30825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IOD14_RS30835	COG1609	Transcriptional regulator
IOD14_RS30840	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IOD14_RS30845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IOD14_RS30860	COG4122	O-methyltransferase activity
IOD14_RS30865	COG1222	aaa ATPase
IOD14_RS30885	COG0517	IMP dehydrogenase activity
IOD14_RS30885	COG1994	Peptidase M50
IOD14_RS30895	COG2197	response regulator
IOD14_RS30900	COG4166	transmembrane transport
IOD14_RS30905	COG4166	transmembrane transport
IOD14_RS30915	COG0646	methionine synthase
IOD14_RS30915	COG1410	methionine synthase
IOD14_RS30920	COG1414	Transcriptional regulator
IOD14_RS30925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD14_RS30930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD14_RS30935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD14_RS30940	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IOD14_RS30950	COG1129	ABC transporter
IOD14_RS30960	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IOD14_RS30965	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IOD14_RS30970	COG0235	Class ii aldolase
IOD14_RS30975	COG0235	Class ii aldolase
IOD14_RS30975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IOD14_RS30980	COG2186	Transcriptional regulator
IOD14_RS31000	COG1404	Belongs to the peptidase S8 family
IOD14_RS31010	COG0215	cysteine-tRNA ligase activity
IOD14_RS31025	COG0406	alpha-ribazole phosphatase activity
IOD14_RS31030	COG0598	Magnesium transport protein CorA
IOD14_RS31040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS31045	COG0667	Aldo Keto reductase
IOD14_RS31075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD14_RS31090	COG0308	aminopeptidase N
IOD14_RS31095	COG3012	SEC-C Motif Domain Protein
IOD14_RS31100	COG2186	Transcriptional regulator
IOD14_RS31105	COG3265	gluconokinase activity
IOD14_RS31140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IOD14_RS31145	COG2149	membrane
IOD14_RS31165	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS31175	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS31180	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS31185	COG3876	Protein conserved in bacteria
IOD14_RS31235	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS31245	COG0640	Transcriptional regulator
IOD14_RS31255	COG0477	Major facilitator Superfamily
IOD14_RS31295	COG2851	Citrate transporter
IOD14_RS31300	COG0243	molybdopterin cofactor binding
IOD14_RS31305	COG1309	transcriptional regulator
IOD14_RS31315	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IOD14_RS31320	COG2188	Transcriptional regulator
IOD14_RS31355	COG1595	DNA-templated transcription, initiation
IOD14_RS31370	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD14_RS31375	COG2815	serine threonine protein kinase
IOD14_RS31375	COG0515	serine threonine protein kinase
IOD14_RS31380	COG2755	lipolytic protein G-D-S-L family
IOD14_RS31400	COG0463	Glycosyl transferase, family 2
IOD14_RS31410	COG0726	polysaccharide deacetylase
IOD14_RS31410	COG1649	PFAM Uncharacterised BCR, COG1649
IOD14_RS31435	COG1725	Transcriptional regulator
IOD14_RS31480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD14_RS31485	COG0587	DNA-directed DNA polymerase activity
IOD14_RS31550	COG0330	HflC and HflK could
IOD14_RS31575	COG1126	abc transporter atp-binding protein
IOD14_RS31585	COG0765	amino acid transport
IOD14_RS31590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD14_RS31595	COG1799	cell septum assembly
IOD14_RS31600	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS31605	COG0477	Major facilitator Superfamily
IOD14_RS31620	COG0671	phosphoesterase, PA-phosphatase related
IOD14_RS31630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD14_RS31640	COG0596	Alpha beta hydrolase
IOD14_RS31665	COG0411	ABC transporter
IOD14_RS31675	COG3583	domain protein
IOD14_RS31690	COG1160	GTP binding
IOD14_RS31700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IOD14_RS31745	COG1187	pseudouridine synthase activity
IOD14_RS31750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IOD14_RS31755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IOD14_RS31770	COG0686	Belongs to the AlaDH PNT family
IOD14_RS31780	COG0494	nUDIX hydrolase
IOD14_RS31785	COG0504	CTP synthase activity
IOD14_RS31790	COG3387	PFAM Glycoside hydrolase 15-related
IOD14_RS31815	COG0497	DNA recombination
IOD14_RS31820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOD14_RS31840	COG1120	ATPase activity
IOD14_RS31845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD14_RS31850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD14_RS31855	COG0647	UMP catabolic process
IOD14_RS31885	COG2094	Belongs to the DNA glycosylase MPG family
IOD14_RS31895	COG1881	PFAM PEBP family protein
IOD14_RS31915	COG1119	ATPase activity
IOD14_RS31935	COG2197	response regulator
IOD14_RS31945	COG4221	oxidoreductase activity
IOD14_RS31950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IOD14_RS31960	COG0842	Transport permease protein
IOD14_RS31960	COG1716	ATPase activity
IOD14_RS31960	COG1131	(ABC) transporter
IOD14_RS31970	COG0560	Phosphoserine phosphatase
IOD14_RS31970	COG3830	Belongs to the UPF0237 family
IOD14_RS31975	COG0588	phosphoglycerate mutase activity
IOD14_RS31990	COG2186	Transcriptional regulator
IOD14_RS32010	COG0312	modulator of DNA gyrase
IOD14_RS32020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOD14_RS32040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOD14_RS32045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD14_RS32065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS32075	COG1063	alcohol dehydrogenase
IOD14_RS32095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD14_RS32120	COG1966	Carbon starvation protein
IOD14_RS32145	COG3387	PFAM Glycoside hydrolase 15-related
IOD14_RS32185	COG1024	Enoyl-CoA hydratase
IOD14_RS32195	COG0488	(ABC) transporter
IOD14_RS32220	COG0235	Class ii aldolase
IOD14_RS32240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IOD14_RS32245	COG1492	cobalamin metabolic process
IOD14_RS32265	COG1797	cobyrinic acid a,c-diamide synthase activity
IOD14_RS32300	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IOD14_RS32330	COG1126	abc transporter atp-binding protein
IOD14_RS32335	COG0765	amino acid transport
IOD14_RS32340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD14_RS32345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOD14_RS32350	COG0456	acetyltransferase
IOD14_RS32355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD14_RS32360	COG1917	Cupin 2, conserved barrel domain protein
IOD14_RS32365	COG5285	phytanoyl-CoA dioxygenase
IOD14_RS32380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD14_RS32400	COG1414	Transcriptional regulator
IOD14_RS32415	COG2252	PERMEase
IOD14_RS32420	COG1595	DNA-templated transcription, initiation
IOD14_RS32450	COG4677	pectinesterase activity
IOD14_RS32455	COG4677	pectinesterase activity
IOD14_RS32460	COG3866	Pectate lyase
IOD14_RS32465	COG2755	lipolytic protein G-D-S-L family
IOD14_RS32475	COG4677	pectinesterase activity
IOD14_RS32480	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD14_RS32500	COG0395	ABC-type sugar transport system, permease component
IOD14_RS32515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS32520	COG1802	Transcriptional regulator
IOD14_RS32545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS32550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD14_RS32555	COG1349	DNA-binding transcription factor activity
IOD14_RS32570	COG0395	ABC-type sugar transport system, permease component
IOD14_RS32575	COG1063	alcohol dehydrogenase
IOD14_RS32585	COG1309	transcriptional regulator
IOD14_RS32595	COG1802	Transcriptional regulator
IOD14_RS32650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS32660	COG1595	DNA-templated transcription, initiation
IOD14_RS32670	COG2171	N-acyltransferase activity
IOD14_RS32675	COG3226	Transcriptional regulator
IOD14_RS32690	COG2151	metal-sulfur cluster biosynthetic enzyme
IOD14_RS32695	COG0822	iron-sulfur transferase activity
IOD14_RS32700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD14_RS32705	COG0396	ATPase activity
IOD14_RS32715	COG0719	Fe-S assembly protein
IOD14_RS32730	COG2746	aminoglycoside 3-N-acetyltransferase activity
IOD14_RS32735	COG1131	(ABC) transporter
IOD14_RS32750	COG0438	transferase activity, transferring glycosyl groups
IOD14_RS32760	COG1612	heme a metabolic process
IOD14_RS32780	COG0109	protoheme IX farnesyltransferase activity
IOD14_RS32790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD14_RS32805	COG0363	glucosamine-6-phosphate deaminase activity
IOD14_RS32815	COG0166	Belongs to the GPI family
IOD14_RS32825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD14_RS32830	COG0149	triose-phosphate isomerase activity
IOD14_RS32835	COG0126	phosphoglycerate kinase activity
IOD14_RS32840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD14_RS32850	COG1481	regulation of sporulation
IOD14_RS32855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IOD14_RS32860	COG1660	Displays ATPase and GTPase activities
IOD14_RS32865	COG0322	excinuclease ABC activity
IOD14_RS32870	COG2197	response regulator
IOD14_RS32880	COG4585	Histidine kinase
IOD14_RS32885	COG2201	protein-glutamate methylesterase activity
IOD14_RS32895	COG1609	Transcriptional regulator
IOD14_RS32905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD14_RS32915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD14_RS32920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD14_RS32925	COG0765	amino acid transport
IOD14_RS32935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IOD14_RS32940	COG1619	proteins homologs of microcin C7 resistance protein MccF
IOD14_RS32945	COG0477	Major facilitator Superfamily
IOD14_RS32950	COG0387	Pfam Sodium calcium exchanger
IOD14_RS32975	COG0556	nucleotide-excision repair
IOD14_RS32985	COG0584	glycerophosphoryl diester phosphodiesterase
IOD14_RS32990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD14_RS32995	COG1063	alcohol dehydrogenase
IOD14_RS33005	COG2313	pseudouridylate synthase activity
IOD14_RS33010	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IOD14_RS33010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IOD14_RS33015	COG2226	methyltransferase
IOD14_RS33020	COG0598	Magnesium transport protein CorA
IOD14_RS33050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD14_RS33055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD14_RS33080	COG1132	(ABC) transporter
IOD14_RS33090	COG2124	cytochrome p450
IOD14_RS33095	COG0402	S-adenosylhomocysteine deaminase activity
IOD14_RS33120	COG0251	oxidation-reduction process
IOD14_RS33135	COG1953	Uracil, thiamine, allantoin
IOD14_RS33140	COG1802	Transcriptional regulator
IOD14_RS33145	COG2267	carboxylic ester hydrolase activity
IOD14_RS33180	COG0237	dephospho-CoA kinase activity
IOD14_RS33200	COG1643	Atp-dependent helicase
IOD14_RS33240	COG2050	protein possibly involved in aromatic compounds catabolism
IOD14_RS33300	COG0737	Belongs to the 5'-nucleotidase family
IOD14_RS33325	COG4566	intracellular signal transduction
IOD14_RS33330	COG1605	Chorismate mutase
IOD14_RS33330	COG0287	Prephenate dehydrogenase
IOD14_RS33350	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS33360	COG1024	Enoyl-CoA hydratase
IOD14_RS33380	COG0183	Belongs to the thiolase family
IOD14_RS33385	COG1309	transcriptional regulator
IOD14_RS33390	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS33395	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS33405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IOD14_RS33440	COG0070	glutamate synthase
IOD14_RS33440	COG0067	glutamate synthase
IOD14_RS33440	COG0069	glutamate synthase activity
IOD14_RS33470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS33475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD14_RS33485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IOD14_RS33495	COG0159	tryptophan synthase activity
IOD14_RS33500	COG0133	tryptophan synthase activity
IOD14_RS33505	COG0134	indole-3-glycerol-phosphate synthase activity
IOD14_RS33525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD14_RS33530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOD14_RS33550	COG0107	imidazoleglycerol-phosphate synthase activity
IOD14_RS33555	COG0251	oxidation-reduction process
IOD14_RS33560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IOD14_RS33565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOD14_RS33575	COG0131	Imidazoleglycerol-phosphate dehydratase
IOD14_RS33580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD14_RS33585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IOD14_RS33600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD14_RS33625	COG1432	Conserved Protein
IOD14_RS33635	COG0587	DNA-directed DNA polymerase activity
IOD14_RS33690	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IOD14_RS33700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOD14_RS33705	COG3599	regulation of cell shape
IOD14_RS33715	COG1799	cell septum assembly
IOD14_RS33725	COG1496	oxidoreductase activity
IOD14_RS33730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOD14_RS33735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IOD14_RS33740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IOD14_RS33750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IOD14_RS33755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD14_RS33765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOD14_RS33780	COG0275	rRNA processing
IOD14_RS33790	COG0714	Associated with various cellular activities
IOD14_RS33820	COG1716	ATPase activity
IOD14_RS33820	COG1131	(ABC) transporter
IOD14_RS33820	COG0842	Transport permease protein
IOD14_RS33830	COG1309	transcriptional regulator
IOD14_RS33855	COG0352	thiamine-phosphate diphosphorylase activity
IOD14_RS33875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD14_RS33875	COG2022	thiamine diphosphate biosynthetic process
IOD14_RS33885	COG2022	thiamine diphosphate biosynthetic process
IOD14_RS33890	COG2815	serine threonine protein kinase
IOD14_RS33890	COG0515	serine threonine protein kinase
IOD14_RS33895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IOD14_RS33905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IOD14_RS33910	COG2193	ferroxidase activity
IOD14_RS33915	COG0243	molybdopterin cofactor binding
IOD14_RS33920	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IOD14_RS33935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD14_RS33940	COG0205	6-phosphofructokinase activity
IOD14_RS33975	COG1940	carbohydrate kinase activity
IOD14_RS33985	COG0003	Pfam Anion-transporting ATPase
IOD14_RS34055	COG0515	serine threonine protein kinase
IOD14_RS34055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS34060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD14_RS34065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD14_RS34070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IOD14_RS34075	COG0723	plastoquinol--plastocyanin reductase activity
IOD14_RS34080	COG2010	Cytochrome c
IOD14_RS34085	COG1845	cytochrome c oxidase, subunit III
IOD14_RS34095	COG1376	ErfK ybiS ycfS ynhG family protein
IOD14_RS34105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD14_RS34110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IOD14_RS34120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS34140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IOD14_RS34145	COG0515	serine threonine protein kinase
IOD14_RS34145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS34150	COG4941	Belongs to the sigma-70 factor family
IOD14_RS34155	COG3795	YCII-related domain
IOD14_RS34160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD14_RS34165	COG2197	response regulator
IOD14_RS34190	COG2226	methyltransferase
IOD14_RS34210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IOD14_RS34215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IOD14_RS34215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IOD14_RS34230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IOD14_RS34240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IOD14_RS34245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD14_RS34250	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD14_RS34265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IOD14_RS34305	COG1090	epimerase
IOD14_RS34320	COG0321	lipoyl(octanoyl) transferase activity
IOD14_RS34325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOD14_RS34350	COG0174	glutamine synthetase
IOD14_RS34365	COG0501	Belongs to the peptidase M48B family
IOD14_RS34430	COG0745	RESPONSE REGULATOR receiver
IOD14_RS34445	COG2197	response regulator
IOD14_RS34500	COG0366	Alpha amylase catalytic
IOD14_RS34505	COG3833	ABC-type maltose transport systems, permease component
IOD14_RS34510	COG1175	transmembrane transport
IOD14_RS34515	COG2182	Extracellular solute-binding protein
IOD14_RS34520	COG1609	Transcriptional regulator
IOD14_RS34530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IOD14_RS34580	COG0174	glutamine synthetase
IOD14_RS34615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IOD14_RS34620	COG0477	Major facilitator Superfamily
IOD14_RS34635	COG2814	Major facilitator Superfamily
IOD14_RS34655	COG1994	Peptidase M50
IOD14_RS34705	COG2837	iron assimilation
IOD14_RS34710	COG0672	)-iron permease
IOD14_RS34740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS34745	COG2814	Major facilitator Superfamily
IOD14_RS34765	COG1136	(ABC) transporter
IOD14_RS34790	COG0006	proline dipeptidase activity
IOD14_RS34795	COG0235	Class ii aldolase
IOD14_RS34800	COG2160	L-arabinose isomerase activity
IOD14_RS34810	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS34815	COG1129	ABC transporter
IOD14_RS34870	COG1201	RNA secondary structure unwinding
IOD14_RS34990	COG0557	exoribonuclease II activity
IOD14_RS34995	COG3022	response to hydroperoxide
IOD14_RS35000	COG0800	Aldolase
IOD14_RS35015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOD14_RS35030	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS35040	COG2030	dehydratase
IOD14_RS35050	COG2197	response regulator
IOD14_RS35070	COG0477	Major facilitator Superfamily
IOD14_RS35085	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD14_RS35095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS35120	COG1309	transcriptional regulator
IOD14_RS35140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD14_RS35160	COG3845	ABC transporter
IOD14_RS35180	COG3619	membrane
IOD14_RS35185	COG2267	carboxylic ester hydrolase activity
IOD14_RS35190	COG1396	sequence-specific DNA binding
IOD14_RS35210	COG0183	Belongs to the thiolase family
IOD14_RS35215	COG2124	cytochrome p450
IOD14_RS35230	COG4122	O-methyltransferase activity
IOD14_RS35310	COG2267	carboxylic ester hydrolase activity
IOD14_RS35315	COG2814	Major facilitator Superfamily
IOD14_RS35365	COG3540	Alkaline phosphatase
IOD14_RS35385	COG1358	cellular component organization or biogenesis
IOD14_RS35430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IOD14_RS35435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD14_RS35450	COG0477	Major facilitator Superfamily
IOD14_RS35455	COG1309	transcriptional regulator
IOD14_RS35470	COG0667	Aldo Keto reductase
IOD14_RS35475	COG0789	Transcriptional regulator
IOD14_RS35490	COG1741	Belongs to the pirin family
IOD14_RS35505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD14_RS35510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD14_RS35515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD14_RS35555	COG0583	DNA-binding transcription factor activity
IOD14_RS35580	COG1764	response to oxidative stress
IOD14_RS35585	COG2130	NADP-dependent
IOD14_RS35600	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS35605	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD14_RS35615	COG1879	ABC-type sugar transport system periplasmic component
IOD14_RS35620	COG1609	Transcriptional regulator
IOD14_RS35625	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS35645	COG1129	ABC transporter
IOD14_RS35650	COG4214	carbohydrate transport
IOD14_RS35660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD14_RS35665	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD14_RS35725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS35725	COG0515	serine threonine protein kinase
IOD14_RS35735	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD14_RS35740	COG0395	ABC-type sugar transport system, permease component
IOD14_RS35745	COG1175	transmembrane transport
IOD14_RS35770	COG3386	PFAM SMP-30 Gluconolaconase
IOD14_RS35775	COG1414	Transcriptional regulator
IOD14_RS35805	COG4981	capsule polysaccharide biosynthetic process
IOD14_RS35825	COG2835	tetraacyldisaccharide 4'-kinase activity
IOD14_RS35855	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS35865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IOD14_RS35865	COG0825	malonyl-CoA metabolic process
IOD14_RS35870	COG1077	Cell shape determining protein MreB Mrl
IOD14_RS35915	COG3629	intracellular signal transduction
IOD14_RS35915	COG3903	Transcriptional regulator
IOD14_RS35920	COG0596	Alpha beta hydrolase
IOD14_RS35940	COG0531	amino acid
IOD14_RS35950	COG2223	nitrite transmembrane transporter activity
IOD14_RS35960	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS35965	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS35970	COG2072	flavoprotein involved in K transport
IOD14_RS35975	COG1301	dicarboxylic acid transport
IOD14_RS35980	COG2828	Protein conserved in bacteria
IOD14_RS35990	COG0121	glutamine amidotransferase
IOD14_RS36020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD14_RS36050	COG1132	(ABC) transporter
IOD14_RS36055	COG4585	Histidine kinase
IOD14_RS36060	COG2197	response regulator
IOD14_RS36075	COG4565	transcriptional regulatory protein
IOD14_RS36080	COG3290	protein histidine kinase activity
IOD14_RS36100	COG2197	response regulator
IOD14_RS36120	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS36130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD14_RS36145	COG0583	DNA-binding transcription factor activity
IOD14_RS36165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS36205	COG1070	Carbohydrate kinase
IOD14_RS36220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD14_RS36225	COG0358	DNA primase activity
IOD14_RS36235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IOD14_RS36245	COG2949	membrane
IOD14_RS36265	COG0243	molybdopterin cofactor binding
IOD14_RS36305	COG3896	Chloramphenicol phosphotransferase-like protein
IOD14_RS36310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD14_RS36315	COG2146	nitrite reductase [NAD(P)H] activity
IOD14_RS36315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD14_RS36350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD14_RS36350	COG0574	Belongs to the PEP-utilizing enzyme family
IOD14_RS36355	COG1940	carbohydrate kinase activity
IOD14_RS36355	COG1846	Transcriptional regulator
IOD14_RS36360	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IOD14_RS36390	COG2814	Major facilitator Superfamily
IOD14_RS36405	COG0156	8-amino-7-oxononanoate synthase activity
IOD14_RS36415	COG0477	Major facilitator Superfamily
IOD14_RS36430	COG0667	Aldo Keto reductase
IOD14_RS36440	COG0423	glycine-tRNA ligase activity
IOD14_RS36445	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD14_RS36445	COG3443	Belongs to the bacterial solute-binding protein 9 family
IOD14_RS36450	COG1121	(ABC) transporter
IOD14_RS36455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD14_RS36470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOD14_RS36475	COG1381	Involved in DNA repair and RecF pathway recombination
IOD14_RS36500	COG1595	DNA-templated transcription, initiation
IOD14_RS36510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS36515	COG2197	response regulator
IOD14_RS36520	COG4585	Histidine kinase
IOD14_RS36525	COG2409	Drug exporters of the RND superfamily
IOD14_RS36535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD14_RS36550	COG2723	6-phospho-beta-galactosidase activity
IOD14_RS36570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOD14_RS36635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS36640	COG2867	negative regulation of translational initiation
IOD14_RS36640	COG2226	methyltransferase
IOD14_RS36645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD14_RS36650	COG0736	holo-[acyl-carrier-protein] synthase activity
IOD14_RS36655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD14_RS36690	COG2315	Protein conserved in bacteria
IOD14_RS36700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IOD14_RS36715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS36720	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS36725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD14_RS36740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD14_RS36745	COG1234	tRNA 3'-trailer cleavage
IOD14_RS36750	COG0537	adenosine 5'-monophosphoramidase activity
IOD14_RS36755	COG4946	Tricorn protease homolog
IOD14_RS36755	COG0793	Belongs to the peptidase S41A family
IOD14_RS36780	COG0484	heat shock protein binding
IOD14_RS36785	COG1420	regulation of RNA biosynthetic process
IOD14_RS36825	COG0481	GTPase activity
IOD14_RS36830	COG0268	Binds directly to 16S ribosomal RNA
IOD14_RS36855	COG1234	tRNA 3'-trailer cleavage
IOD14_RS36860	COG1555	photosystem II stabilization
IOD14_RS36860	COG1596	polysaccharide export
IOD14_RS36870	COG1307	EDD domain protein, DegV family
IOD14_RS36880	COG0495	leucyl-tRNA aminoacylation
IOD14_RS36890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IOD14_RS36910	COG0477	Major facilitator Superfamily
IOD14_RS36925	COG0588	phosphoglycerate mutase activity
IOD14_RS36930	COG0799	negative regulation of ribosome biogenesis
IOD14_RS36940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IOD14_RS36955	COG0501	Belongs to the peptidase M48B family
IOD14_RS36970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IOD14_RS36980	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IOD14_RS36995	COG1215	transferase activity, transferring glycosyl groups
IOD14_RS37015	COG3540	Alkaline phosphatase
IOD14_RS37025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IOD14_RS37030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IOD14_RS37035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IOD14_RS37065	COG1530	ribonuclease E activity
IOD14_RS37165	COG1074	ATP-dependent DNA helicase activity
IOD14_RS37215	COG0772	Belongs to the SEDS family
IOD14_RS37235	COG1077	Cell shape determining protein MreB Mrl
IOD14_RS37240	COG0105	UTP biosynthetic process
IOD14_RS37250	COG0285	dihydrofolate synthase activity
IOD14_RS37255	COG0525	valine-tRNA ligase activity
IOD14_RS37265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IOD14_RS37270	COG0740	serine-type endopeptidase activity
IOD14_RS37275	COG0740	serine-type endopeptidase activity
IOD14_RS37280	COG0544	peptidyl-prolyl cis-trans isomerase activity
IOD14_RS37300	COG3594	Acyltransferase
IOD14_RS37315	COG0577	efflux transmembrane transporter activity
IOD14_RS37315	COG1136	(ABC) transporter
IOD14_RS37325	COG4552	Acetyltransferase involved in intracellular survival and related
IOD14_RS37335	COG0698	ribose 5-phosphate isomerase
IOD14_RS37340	COG1113	amino acid transport
IOD14_RS37375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD14_RS37380	COG1116	anion transmembrane transporter activity
IOD14_RS37385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS37395	COG1113	amino acid transport
IOD14_RS37400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOD14_RS37410	COG0588	phosphoglycerate mutase activity
IOD14_RS37425	COG1070	Carbohydrate kinase
IOD14_RS37435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOD14_RS37465	COG1051	belongs to the nudix hydrolase family
IOD14_RS37540	COG0697	spore germination
IOD14_RS37545	COG1846	Transcriptional regulator
IOD14_RS37550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD14_RS37580	COG1136	(ABC) transporter
IOD14_RS37595	COG0668	transmembrane transport
IOD14_RS37605	COG1940	carbohydrate kinase activity
IOD14_RS37610	COG1653	transport
IOD14_RS37615	COG1175	transmembrane transport
IOD14_RS37620	COG0395	ABC-type sugar transport system, permease component
IOD14_RS37625	COG1486	melibiose metabolic process
IOD14_RS37675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOD14_RS37680	COG2346	COG2346, Truncated hemoglobins
IOD14_RS37695	COG0577	efflux transmembrane transporter activity
IOD14_RS37695	COG1136	(ABC) transporter
IOD14_RS37730	COG3903	Transcriptional regulator
IOD14_RS37730	COG3629	intracellular signal transduction
IOD14_RS37755	COG0629	single-stranded DNA binding
IOD14_RS37875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD14_RS37890	COG2304	oxidoreductase activity
IOD14_RS37945	COG0728	peptidoglycan biosynthetic process
IOD14_RS37955	COG0438	transferase activity, transferring glycosyl groups
IOD14_RS38045	COG3962	Belongs to the TPP enzyme family
IOD14_RS38050	COG3718	enzyme involved in inositol metabolism
IOD14_RS38060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS38085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD14_RS38095	COG2409	Drug exporters of the RND superfamily
IOD14_RS38120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD14_RS38130	COG1129	ABC transporter
IOD14_RS38140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD14_RS38145	COG1869	D-ribose catabolic process
IOD14_RS38175	COG0673	inositol 2-dehydrogenase activity
IOD14_RS38205	COG1846	Transcriptional regulator
IOD14_RS38205	COG0456	acetyltransferase
IOD14_RS38230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOD14_RS38240	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD14_RS38275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IOD14_RS38280	COG2356	endonuclease I
IOD14_RS38285	COG0028	Belongs to the TPP enzyme family
IOD14_RS38295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD14_RS38310	COG1946	Acyl-CoA thioesterase
IOD14_RS38320	COG1309	transcriptional regulator
IOD14_RS38325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD14_RS38340	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS38360	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IOD14_RS38395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD14_RS38400	COG0589	response to stress
IOD14_RS38410	COG4977	sequence-specific DNA binding
IOD14_RS38415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IOD14_RS38425	COG0583	DNA-binding transcription factor activity
IOD14_RS38445	COG1175	transmembrane transport
IOD14_RS38470	COG3345	alpha-galactosidase
IOD14_RS38475	COG0395	ABC-type sugar transport system, permease component
IOD14_RS38480	COG1175	transmembrane transport
IOD14_RS38485	COG1653	transport
IOD14_RS38490	COG3979	chitinase
IOD14_RS38500	COG0745	RESPONSE REGULATOR receiver
IOD14_RS38525	COG0406	alpha-ribazole phosphatase activity
IOD14_RS38575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD14_RS38600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD14_RS38615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD14_RS38620	COG0765	amino acid transport
IOD14_RS38625	COG0765	amino acid transport
IOD14_RS38630	COG1126	abc transporter atp-binding protein
IOD14_RS38645	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS38655	COG3397	chitin binding
IOD14_RS38725	COG0673	inositol 2-dehydrogenase activity
IOD14_RS38730	COG4702	Belongs to the UPF0303 family
IOD14_RS38765	COG3764	Sortase (surface protein transpeptidase)
IOD14_RS38890	COG2733	membrane
IOD14_RS38905	COG4555	ABC transporter
IOD14_RS38920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD14_RS38925	COG2076	Multidrug Resistance protein
IOD14_RS38960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IOD14_RS38970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IOD14_RS38975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD14_RS38980	COG1263	PTS System
IOD14_RS38985	COG1263	PTS System
IOD14_RS38990	COG1234	tRNA 3'-trailer cleavage
IOD14_RS39015	COG1113	amino acid transport
IOD14_RS39025	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IOD14_RS39035	COG1335	isochorismatase
IOD14_RS39070	COG0277	FAD linked oxidase domain protein
IOD14_RS39095	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IOD14_RS39120	COG4948	Mandelate Racemase Muconate Lactonizing
IOD14_RS39185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IOD14_RS39190	COG0395	ABC-type sugar transport system, permease component
IOD14_RS39195	COG1175	transmembrane transport
IOD14_RS39210	COG1678	Uncharacterized ACR, COG1678
IOD14_RS39215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOD14_RS39220	COG0776	regulation of translation
IOD14_RS39230	COG3973	AAA domain
IOD14_RS39260	COG2223	nitrite transmembrane transporter activity
IOD14_RS39310	COG0583	DNA-binding transcription factor activity
IOD14_RS39330	COG0395	ABC-type sugar transport system, permease component
IOD14_RS39335	COG1501	Belongs to the glycosyl hydrolase 31 family
IOD14_RS39350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IOD14_RS39355	COG0793	Belongs to the peptidase S41A family
IOD14_RS39360	COG2177	Part of the ABC transporter FtsEX involved in
IOD14_RS39365	COG2884	Cell division ATP-binding protein ftsE
IOD14_RS39380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IOD14_RS39385	COG0515	serine threonine protein kinase
IOD14_RS39390	COG0515	serine threonine protein kinase
IOD14_RS39400	COG1653	transport
IOD14_RS39405	COG1175	transmembrane transport
IOD14_RS39410	COG0395	ABC-type sugar transport system, permease component
IOD14_RS39415	COG1216	Glycosyl transferase, family 2
IOD14_RS39425	COG1846	Transcriptional regulator
IOD14_RS39430	COG1764	response to oxidative stress
IOD14_RS39455	COG1134	teichoic acid transport
IOD14_RS39460	COG2902	Dehydrogenase
IOD14_RS39485	COG0653	protein targeting
IOD14_RS39490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD14_RS39495	COG3214	Protein conserved in bacteria
IOD14_RS39500	COG2197	response regulator
IOD14_RS39505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD14_RS39510	COG0823	Involved in the tonB-independent uptake of proteins
IOD14_RS39515	COG5002	protein histidine kinase activity
IOD14_RS39520	COG0745	RESPONSE REGULATOR receiver
IOD14_RS39525	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IOD14_RS39545	COG0714	Associated with various cellular activities
IOD14_RS39585	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IOD14_RS39590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD14_RS39590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD14_RS39590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD14_RS39600	COG1482	cell wall glycoprotein biosynthetic process
IOD14_RS39610	COG2835	tetraacyldisaccharide 4'-kinase activity
IOD14_RS39620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD14_RS39625	COG1620	l-lactate permease
IOD14_RS39660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IOD14_RS39665	COG0778	Nitroreductase
IOD14_RS39665	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IOD14_RS39690	COG1316	TRANSCRIPTIONal
IOD14_RS39695	COG1316	TRANSCRIPTIONal
IOD14_RS39700	COG1316	TRANSCRIPTIONal
IOD14_RS39705	COG1316	TRANSCRIPTIONal
IOD14_RS39720	COG1316	TRANSCRIPTIONal
IOD14_RS39730	COG1316	TRANSCRIPTIONal
IOD14_RS39750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IOD14_RS39795	COG2205	protein histidine kinase activity
IOD14_RS39800	COG0745	RESPONSE REGULATOR receiver
IOD14_RS39805	COG3104	oligopeptide transport
IOD14_RS39830	COG1366	Belongs to the anti-sigma-factor antagonist family
IOD14_RS39835	COG1191	sigma factor activity
IOD14_RS39865	COG1228	amidohydrolase
IOD14_RS39875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD14_RS39880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IOD14_RS39930	COG1174	glycine betaine transport
IOD14_RS39935	COG1174	glycine betaine transport
IOD14_RS39965	COG2755	lipolytic protein G-D-S-L family
IOD14_RS39970	COG0183	Belongs to the thiolase family
IOD14_RS40035	COG1136	(ABC) transporter
IOD14_RS40040	COG0577	efflux transmembrane transporter activity
IOD14_RS40045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD14_RS40050	COG1252	NADH dehydrogenase
IOD14_RS40070	COG0148	phosphopyruvate hydratase activity
IOD14_RS40180	COG0577	efflux transmembrane transporter activity
IOD14_RS40185	COG1136	(ABC) transporter
IOD14_RS40190	COG0477	Major facilitator Superfamily
IOD14_RS40200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD14_RS40230	COG4585	Histidine kinase
IOD14_RS40240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOD14_RS40245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOD14_RS40250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IOD14_RS40255	COG0193	aminoacyl-tRNA hydrolase activity
IOD14_RS40270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IOD14_RS40280	COG1309	transcriptional regulator
IOD14_RS40315	COG4106	trans-aconitate 2-methyltransferase activity
IOD14_RS40325	COG2197	response regulator
IOD14_RS40340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IOD14_RS40370	COG0488	(ABC) transporter
IOD14_RS40375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IOD14_RS40380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD14_RS40385	COG3583	domain protein
IOD14_RS40385	COG3584	3D domain protein
IOD14_RS40390	COG0084	hydrolase, TatD family'
IOD14_RS40415	COG0768	penicillin binding
IOD14_RS40425	COG0310	cobalt ion transport
IOD14_RS40435	COG1122	ATPase activity
IOD14_RS40440	COG1846	Transcriptional regulator
IOD14_RS40445	COG1764	response to oxidative stress
IOD14_RS40450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD14_RS40480	COG0442	prolyl-tRNA aminoacylation
IOD14_RS40485	COG0456	acetyltransferase
IOD14_RS40490	COG2409	Drug exporters of the RND superfamily
IOD14_RS40500	COG0793	Belongs to the peptidase S41A family
IOD14_RS40500	COG4946	Tricorn protease homolog
IOD14_RS40510	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS40515	COG2267	carboxylic ester hydrolase activity
IOD14_RS40520	COG2072	flavoprotein involved in K transport
IOD14_RS40530	COG0708	Exodeoxyribonuclease III
IOD14_RS40555	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD14_RS40555	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD14_RS40560	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD14_RS40570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD14_RS40575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD14_RS40600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IOD14_RS40610	COG1970	mechanosensitive ion channel activity
IOD14_RS40625	COG3191	aminopeptidase activity
IOD14_RS40630	COG1376	ErfK ybiS ycfS ynhG family protein
IOD14_RS40645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD14_RS40645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD14_RS40655	COG1349	DNA-binding transcription factor activity
IOD14_RS40660	COG0477	Major facilitator Superfamily
IOD14_RS40670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD14_RS40675	COG1247	-acetyltransferase
IOD14_RS40680	COG3384	dioxygenase
IOD14_RS40685	COG1846	Transcriptional regulator
IOD14_RS40705	COG1414	Transcriptional regulator
IOD14_RS40775	COG3973	AAA domain
IOD14_RS40815	COG0386	Belongs to the glutathione peroxidase family
IOD14_RS40835	COG1686	Belongs to the peptidase S11 family
IOD14_RS40880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IOD14_RS40950	COG1012	belongs to the aldehyde dehydrogenase family
IOD14_RS40955	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IOD14_RS40965	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS40985	COG3629	intracellular signal transduction
IOD14_RS40985	COG3903	Transcriptional regulator
IOD14_RS40995	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS41010	COG1024	Enoyl-CoA hydratase
IOD14_RS41015	COG0596	Alpha beta hydrolase
IOD14_RS41025	COG0515	serine threonine protein kinase
IOD14_RS41025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD14_RS41035	COG1309	transcriptional regulator
IOD14_RS41045	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS41055	COG1404	Belongs to the peptidase S8 family
IOD14_RS41070	COG0259	pyridoxamine-phosphate oxidase activity
IOD14_RS41100	COG2072	flavoprotein involved in K transport
IOD14_RS41105	COG1231	oxidoreductase activity
IOD14_RS41115	COG1024	Enoyl-CoA hydratase
IOD14_RS41140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IOD14_RS41145	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS41150	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS41165	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS41170	COG1960	acyl-CoA dehydrogenase activity
IOD14_RS41175	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS41240	COG0596	Alpha beta hydrolase
IOD14_RS41240	COG2945	thiolester hydrolase activity
IOD14_RS41250	COG4821	SIS domain
IOD14_RS41265	COG0259	pyridoxamine-phosphate oxidase activity
IOD14_RS41285	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS41300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD14_RS41325	COG5006	permease, DMT superfamily
IOD14_RS41335	COG0247	lactate metabolic process
IOD14_RS41335	COG0277	FAD linked oxidase domain protein
IOD14_RS41340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IOD14_RS41345	COG0596	Alpha beta hydrolase
IOD14_RS41350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IOD14_RS41415	COG1595	DNA-templated transcription, initiation
IOD14_RS41420	COG0154	amidase activity
IOD14_RS41425	COG0667	Aldo Keto reductase
IOD14_RS41455	COG2252	PERMEase
IOD14_RS41465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IOD14_RS41485	COG1595	DNA-templated transcription, initiation
IOD14_RS41500	COG2814	Major facilitator Superfamily
IOD14_RS41510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD14_RS41515	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IOD14_RS41560	COG1061	Type III restriction enzyme res subunit
IOD14_RS41570	COG3973	AAA domain
IOD14_RS41600	COG1737	Transcriptional regulator
IOD14_RS41605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IOD14_RS41615	COG4106	trans-aconitate 2-methyltransferase activity
IOD14_RS41640	COG0459	protein refolding
IOD14_RS41645	COG1278	Cold shock
IOD14_RS41660	COG0463	Glycosyl transferase, family 2
IOD14_RS41695	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD14_RS41705	COG5001	Diguanylate cyclase
IOD14_RS41705	COG3300	MHYT domain
IOD14_RS41820	COG0745	RESPONSE REGULATOR receiver
IOD14_RS41825	COG2205	protein histidine kinase activity
IOD14_RS41835	COG3842	ATPase activity
IOD14_RS41845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IOD14_RS41855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD14_RS41860	COG0215	cysteine-tRNA ligase activity
IOD14_RS41865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IOD14_RS41870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IOD14_RS41875	COG1329	Transcriptional regulator
IOD14_RS41890	COG5002	protein histidine kinase activity
IOD14_RS41915	COG0076	glutamate decarboxylase activity
IOD14_RS41920	COG0588	phosphoglycerate mutase activity
IOD14_RS41950	COG0438	transferase activity, transferring glycosyl groups
IOD14_RS42015	COG2226	methyltransferase
IOD14_RS42025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD14_RS42035	COG3973	AAA domain
IOD14_RS42055	COG2186	Transcriptional regulator
IOD14_RS42065	COG2188	Transcriptional regulator
IOD14_RS42075	COG2188	Transcriptional regulator
IOD14_RS42085	COG4552	Acetyltransferase involved in intracellular survival and related
IOD14_RS42095	COG1490	D-aminoacyl-tRNA deacylase activity
IOD14_RS42120	COG3485	protocatechuate 3,4-dioxygenase
IOD14_RS42160	COG2897	thiosulfate sulfurtransferase activity
IOD14_RS42195	COG0745	RESPONSE REGULATOR receiver
IOD14_RS42200	COG1609	Transcriptional regulator
IOD14_RS42205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD14_RS42215	COG0745	RESPONSE REGULATOR receiver
IOD14_RS42240	COG1132	(ABC) transporter
IOD14_RS42250	COG0737	Belongs to the 5'-nucleotidase family
IOD14_RS42255	COG0456	acetyltransferase
IOD14_RS42290	COG1725	Transcriptional regulator
IOD14_RS42295	COG1131	(ABC) transporter
IOD14_RS42310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IOD14_RS42335	COG1937	Protein conserved in bacteria
IOD14_RS42345	COG0306	phosphate transporter
IOD14_RS42350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOD14_RS42370	COG0277	FAD linked oxidase domain protein
IOD14_RS42375	COG0671	phosphoesterase, PA-phosphatase related
IOD14_RS42380	COG0741	lytic transglycosylase activity
IOD14_RS42380	COG0739	heme binding
IOD14_RS42380	COG1196	nuclear chromosome segregation
IOD14_RS42440	COG1131	(ABC) transporter
IOD14_RS42450	COG4585	Histidine kinase
IOD14_RS42455	COG2197	response regulator
IOD14_RS42490	COG1252	NADH dehydrogenase
IOD14_RS42520	COG0579	oxidoreductase
IOD14_RS42525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOD14_RS42535	COG0667	Aldo Keto reductase
IOD14_RS42575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD14_RS42585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD14_RS42585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD14_RS42665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOD14_RS42740	COG0513	Belongs to the DEAD box helicase family
IOD14_RS42775	COG1643	Atp-dependent helicase
IOD14_RS42810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IOD14_RS42830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD14_RS42835	COG0047	phosphoribosylformylglycinamidine synthase activity
IOD14_RS42840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD14_RS42860	COG1131	(ABC) transporter
IOD14_RS42875	COG2197	response regulator
IOD14_RS42885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IOD14_RS42900	COG0151	Belongs to the GarS family
IOD14_RS42985	COG2188	Transcriptional regulator
IOD14_RS42990	COG0456	acetyltransferase
IOD14_RS43070	COG2188	Transcriptional regulator
IOD14_RS43075	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD14_RS43110	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IOD14_RS43175	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS43180	COG1801	Protein of unknown function DUF72
IOD14_RS43190	COG1028	Short-chain dehydrogenase reductase Sdr
IOD14_RS43230	COG0433	COG0433 Predicted ATPase
IOD14_RS43245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IOD14_RS43280	COG1191	sigma factor activity
IOD14_RS43285	COG1191	sigma factor activity
IOD14_RS43300	COG0477	Major facilitator Superfamily
IOD14_RS43305	COG2353	YceI-like domain
IOD14_RS43310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOD14_RS43315	COG3467	pyridoxamine 5'-phosphate
IOD14_RS43325	COG0477	Major facilitator Superfamily
IOD14_RS43330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IOD14_RS43340	COG2205	protein histidine kinase activity
IOD14_RS43345	COG0745	RESPONSE REGULATOR receiver
IOD14_RS43365	COG1846	Transcriptional regulator
IOD14_RS43400	COG1309	transcriptional regulator
IOD14_RS43405	COG2814	Major facilitator Superfamily
IOD14_RS43410	COG0318	PFAM AMP-dependent synthetase and ligase
IOD14_RS43415	COG1595	DNA-templated transcription, initiation
IOD14_RS43460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD14_RS43475	COG0653	protein targeting
IOD14_RS43495	COG0006	proline dipeptidase activity
IOD14_RS43500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD14_RS43510	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IOD14_RS43535	COG1999	signal sequence binding
IOD14_RS43550	COG2837	iron assimilation
IOD14_RS43560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IOD14_RS43565	COG0561	phosphatase activity
IOD14_RS43595	COG1131	(ABC) transporter
IOD14_RS43615	COG0789	Transcriptional regulator
IOD14_RS43620	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IOD14_RS43635	COG0561	phosphatase activity
IOD14_RS43640	COG1196	nuclear chromosome segregation
IOD14_RS43640	COG0741	lytic transglycosylase activity
IOD14_RS43640	COG0739	heme binding
IOD14_RS43650	COG4988	ABC transporter
IOD14_RS43655	COG1294	oxidase, subunit
IOD14_RS43660	COG1271	oxidase subunit
IOD14_RS43665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD14_RS43670	COG1609	Transcriptional regulator
IOD14_RS43685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IOD14_RS43710	COG0662	Cupin 2, conserved barrel domain protein
IOD14_RS43715	COG1950	PFAM Membrane protein of
IOD14_RS43720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOD14_RS43725	COG0626	cystathionine gamma-synthase activity
IOD14_RS43755	COG2814	Major facilitator Superfamily
IOD14_RS43770	COG0305	Participates in initiation and elongation during chromosome replication
IOD14_RS43775	COG0534	Mate efflux family protein
IOD14_RS43780	COG0359	binds to the 23S rRNA
IOD14_RS43785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOD14_RS43790	COG0629	single-stranded DNA binding
IOD14_RS43795	COG0360	Binds together with S18 to 16S ribosomal RNA
IOD14_RS43820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD14_RS43840	COG0617	tRNA 3'-terminal CCA addition
IOD14_RS43860	COG1595	DNA-templated transcription, initiation
IOD14_RS43870	COG0492	ferredoxin-NADP+ reductase activity
IOD14_RS43875	COG3118	belongs to the thioredoxin family
IOD14_RS43890	COG1192	Involved in chromosome partitioning
IOD14_RS43895	COG0357	Ribosomal RNA small subunit methyltransferase G
IOD14_RS43905	COG0706	membrane insertase activity
IOD14_RS43910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD14_RS43915	COG0594	ribonuclease P activity
IOD14_RS44140	COG3629	intracellular signal transduction
IOD14_RS44140	COG3903	Transcriptional regulator
IOD14_RS44155	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD14_RS44195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD14_RS44215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD14_RS44315	COG3293	Transposase
IOD14_RS44585	COG0174	glutamine synthetase
IOD14_RS44630	COG0515	serine threonine protein kinase