locus-tag	class	description
H7H31_RS00045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7H31_RS00055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7H31_RS00060	COG0076	glutamate decarboxylase activity
H7H31_RS00075	COG1846	Transcriptional regulator
H7H31_RS00105	COG0477	Major facilitator Superfamily
H7H31_RS00115	COG2084	Dehydrogenase
H7H31_RS00120	COG1309	transcriptional regulator
H7H31_RS00135	COG1695	Transcriptional regulator
H7H31_RS00150	COG0477	Major facilitator Superfamily
H7H31_RS00155	COG1063	alcohol dehydrogenase
H7H31_RS00160	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS00165	COG2207	Transcriptional regulator
H7H31_RS00195	COG0435	Glutathione S-transferase
H7H31_RS00205	COG1846	Transcriptional regulator
H7H31_RS00210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7H31_RS00215	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS00220	COG1309	transcriptional regulator
H7H31_RS00225	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7H31_RS00240	COG4689	acetoacetate decarboxylase
H7H31_RS00255	COG0174	glutamine synthetase
H7H31_RS00270	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS00280	COG4172	Belongs to the ABC transporter superfamily
H7H31_RS00285	COG0444	Belongs to the ABC transporter superfamily
H7H31_RS00295	COG0747	negative chemotaxis
H7H31_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS00320	COG2197	response regulator
H7H31_RS00345	COG0667	Aldo Keto reductase
H7H31_RS00350	COG0657	acetylesterase activity
H7H31_RS00355	COG2814	Major facilitator Superfamily
H7H31_RS00365	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS00370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7H31_RS00375	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7H31_RS00410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7H31_RS00430	COG1414	Transcriptional regulator
H7H31_RS00445	COG0183	Belongs to the thiolase family
H7H31_RS00450	COG3485	protocatechuate 3,4-dioxygenase
H7H31_RS00455	COG3485	protocatechuate 3,4-dioxygenase
H7H31_RS00460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7H31_RS00465	COG0596	Alpha beta hydrolase
H7H31_RS00500	COG0726	polysaccharide deacetylase
H7H31_RS00510	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS00515	COG0235	Class ii aldolase
H7H31_RS00545	COG2318	DinB family
H7H31_RS00550	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7H31_RS00555	COG2197	response regulator
H7H31_RS00555	COG3903	Transcriptional regulator
H7H31_RS00675	COG2945	thiolester hydrolase activity
H7H31_RS00675	COG0596	Alpha beta hydrolase
H7H31_RS00695	COG3321	synthase
H7H31_RS00695	COG0604	alcohol dehydrogenase
H7H31_RS00700	COG3321	synthase
H7H31_RS00700	COG0604	alcohol dehydrogenase
H7H31_RS00705	COG3321	synthase
H7H31_RS00705	COG0604	alcohol dehydrogenase
H7H31_RS00740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7H31_RS00745	COG1414	Transcriptional regulator
H7H31_RS00775	COG3012	SEC-C Motif Domain Protein
H7H31_RS00795	COG0583	DNA-binding transcription factor activity
H7H31_RS00825	COG2356	endonuclease I
H7H31_RS00835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7H31_RS00840	COG0019	diaminopimelate decarboxylase activity
H7H31_RS00865	COG2124	cytochrome p450
H7H31_RS00870	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS00875	COG0604	alcohol dehydrogenase
H7H31_RS00875	COG3321	synthase
H7H31_RS00910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS00940	COG0640	Transcriptional regulator
H7H31_RS00950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7H31_RS00975	COG1846	Transcriptional regulator
H7H31_RS00995	COG0662	Cupin 2, conserved barrel domain protein
H7H31_RS01050	COG0583	DNA-binding transcription factor activity
H7H31_RS01055	COG1063	alcohol dehydrogenase
H7H31_RS01060	COG0156	8-amino-7-oxononanoate synthase activity
H7H31_RS01080	COG2080	2 iron, 2 sulfur cluster binding
H7H31_RS01085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7H31_RS01090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7H31_RS01120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7H31_RS01145	COG0490	domain, Protein
H7H31_RS01150	COG1793	dna ligase
H7H31_RS01150	COG3285	dna ligase
H7H31_RS01160	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS01170	COG0242	peptide deformylase activity
H7H31_RS01180	COG1492	cobalamin metabolic process
H7H31_RS01185	COG0205	6-phosphofructokinase activity
H7H31_RS01225	COG2319	Wd-40 repeat
H7H31_RS01225	COG4249	Peptidase C14 caspase catalytic subunit p20
H7H31_RS01235	COG0740	serine-type endopeptidase activity
H7H31_RS01255	COG0156	8-amino-7-oxononanoate synthase activity
H7H31_RS01260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7H31_RS01265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7H31_RS01270	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7H31_RS01275	COG4221	oxidoreductase activity
H7H31_RS01280	COG1309	transcriptional regulator
H7H31_RS01315	COG2226	methyltransferase
H7H31_RS01345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7H31_RS01365	COG4585	Histidine kinase
H7H31_RS01370	COG2197	response regulator
H7H31_RS01375	COG1940	carbohydrate kinase activity
H7H31_RS01380	COG2188	Transcriptional regulator
H7H31_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS01435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7H31_RS01455	COG0419	ATPase involved in DNA repair
H7H31_RS01460	COG0420	3'-5' exonuclease activity
H7H31_RS01465	COG1739	Uncharacterized protein family UPF0029
H7H31_RS01470	COG1832	CoA-binding protein
H7H31_RS01480	COG0110	maltose O-acetyltransferase activity
H7H31_RS01505	COG2814	Major facilitator Superfamily
H7H31_RS01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7H31_RS01540	COG1968	undecaprenyl-diphosphatase activity
H7H31_RS01555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7H31_RS01565	COG2318	DinB family
H7H31_RS01575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7H31_RS01580	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS01610	COG0142	geranyltranstransferase activity
H7H31_RS01630	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H7H31_RS01665	COG0604	alcohol dehydrogenase
H7H31_RS01665	COG3321	synthase
H7H31_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS01685	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS01720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7H31_RS01730	COG2124	cytochrome p450
H7H31_RS01785	COG2318	DinB family
H7H31_RS01800	COG4948	Mandelate Racemase Muconate Lactonizing
H7H31_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS01845	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7H31_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS01885	COG3634	alkyl hydroperoxide reductase activity
H7H31_RS01895	COG0726	polysaccharide deacetylase
H7H31_RS01935	COG0697	spore germination
H7H31_RS01970	COG1695	Transcriptional regulator
H7H31_RS01985	COG0384	phenazine biosynthesis protein PhzF
H7H31_RS02010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7H31_RS02010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7H31_RS02020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7H31_RS02060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7H31_RS02090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7H31_RS02100	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H7H31_RS02110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7H31_RS02125	COG2018	Roadblock/LC7 domain
H7H31_RS02155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H7H31_RS02175	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7H31_RS02180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7H31_RS02185	COG1984	allophanate hydrolase subunit 2
H7H31_RS02190	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H7H31_RS02210	COG0438	transferase activity, transferring glycosyl groups
H7H31_RS02235	COG0510	thiamine kinase activity
H7H31_RS02270	COG0515	serine threonine protein kinase
H7H31_RS02295	COG3467	pyridoxamine 5'-phosphate
H7H31_RS02300	COG0515	serine threonine protein kinase
H7H31_RS02305	COG1309	transcriptional regulator
H7H31_RS02310	COG1064	alcohol dehydrogenase
H7H31_RS02320	COG1733	regulation of RNA biosynthetic process
H7H31_RS02330	COG1335	isochorismatase
H7H31_RS02340	COG0529	Catalyzes the synthesis of activated sulfate
H7H31_RS02355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7H31_RS02360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7H31_RS02385	COG4977	sequence-specific DNA binding
H7H31_RS02395	COG1366	Belongs to the anti-sigma-factor antagonist family
H7H31_RS02400	COG1366	Belongs to the anti-sigma-factor antagonist family
H7H31_RS02405	COG2172	sigma factor antagonist activity
H7H31_RS02415	COG2208	phosphoserine phosphatase activity
H7H31_RS02415	COG2770	Histidine kinase
H7H31_RS02420	COG1846	Transcriptional regulator
H7H31_RS02430	COG2376	Dihydroxyacetone kinase
H7H31_RS02435	COG1461	Dihydroxyacetone kinase
H7H31_RS02440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7H31_RS02440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7H31_RS02440	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7H31_RS02450	COG1132	(ABC) transporter
H7H31_RS02455	COG1132	(ABC) transporter
H7H31_RS02480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS02495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS02500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS02510	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H7H31_RS02530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7H31_RS02535	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS02610	COG0464	growth
H7H31_RS02620	COG1349	DNA-binding transcription factor activity
H7H31_RS02665	COG1940	carbohydrate kinase activity
H7H31_RS02685	COG2197	response regulator
H7H31_RS02690	COG4585	Histidine kinase
H7H31_RS02705	COG0445	tRNA wobble uridine modification
H7H31_RS02735	COG0494	nUDIX hydrolase
H7H31_RS02740	COG2815	serine threonine protein kinase
H7H31_RS02740	COG0515	serine threonine protein kinase
H7H31_RS02760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7H31_RS02770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7H31_RS02810	COG0584	glycerophosphoryl diester phosphodiesterase
H7H31_RS02830	COG0671	phosphoesterase, PA-phosphatase related
H7H31_RS02845	COG3424	synthase
H7H31_RS02850	COG2124	cytochrome p450
H7H31_RS02915	COG3547	Transposase (IS116 IS110 IS902 family)
H7H31_RS02920	COG2197	response regulator
H7H31_RS02955	COG2197	response regulator
H7H31_RS02980	COG0513	Belongs to the DEAD box helicase family
H7H31_RS02985	COG1278	Cold shock
H7H31_RS03025	COG2197	response regulator
H7H31_RS03040	COG0464	growth
H7H31_RS03170	COG0384	phenazine biosynthesis protein PhzF
H7H31_RS03190	COG0753	catalase activity
H7H31_RS03200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7H31_RS03200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7H31_RS03215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS03220	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS03225	COG1120	ATPase activity
H7H31_RS03230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7H31_RS03235	COG1132	(ABC) transporter
H7H31_RS03240	COG1132	(ABC) transporter
H7H31_RS03255	COG0515	serine threonine protein kinase
H7H31_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS03340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7H31_RS03360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7H31_RS03365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7H31_RS03375	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7H31_RS03385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7H31_RS03390	COG1120	ATPase activity
H7H31_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS03430	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H7H31_RS03435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7H31_RS03455	COG0475	glutathione-regulated potassium exporter activity
H7H31_RS03475	COG0657	acetylesterase activity
H7H31_RS03500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS03510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7H31_RS03555	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7H31_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS03595	COG0583	DNA-binding transcription factor activity
H7H31_RS03605	COG0326	Molecular chaperone. Has ATPase activity
H7H31_RS03640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7H31_RS03650	COG0531	amino acid
H7H31_RS03700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7H31_RS03705	COG0140	phosphoribosyl-ATP diphosphatase activity
H7H31_RS03710	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7H31_RS03715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7H31_RS03715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7H31_RS03720	COG3201	nicotinamide mononucleotide transporter
H7H31_RS03745	COG4977	sequence-specific DNA binding
H7H31_RS03750	COG1846	Transcriptional regulator
H7H31_RS03750	COG1940	carbohydrate kinase activity
H7H31_RS03755	COG2223	nitrite transmembrane transporter activity
H7H31_RS03760	COG2233	PERMEase
H7H31_RS03775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7H31_RS03830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS03860	COG2390	Transcriptional regulator
H7H31_RS03865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7H31_RS03875	COG2814	Major facilitator Superfamily
H7H31_RS03890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7H31_RS03905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7H31_RS03930	COG0284	orotidine-5'-phosphate decarboxylase activity
H7H31_RS03935	COG0167	dihydroorotate dehydrogenase activity
H7H31_RS03940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7H31_RS03945	COG0505	Belongs to the CarA family
H7H31_RS03955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7H31_RS03960	COG0540	Belongs to the ATCase OTCase family
H7H31_RS03965	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H7H31_RS03975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7H31_RS03980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7H31_RS03985	COG0006	proline dipeptidase activity
H7H31_RS03995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7H31_RS04005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7H31_RS04010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7H31_RS04020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7H31_RS04025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7H31_RS04045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7H31_RS04065	COG0124	histidyl-tRNA synthetase
H7H31_RS04075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7H31_RS04080	COG1196	nuclear chromosome segregation
H7H31_RS04085	COG1846	Transcriptional regulator
H7H31_RS04095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7H31_RS04100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7H31_RS04105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7H31_RS04110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7H31_RS04120	COG2255	four-way junction helicase activity
H7H31_RS04125	COG0632	four-way junction helicase activity
H7H31_RS04130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7H31_RS04135	COG0217	transcriptional regulatory protein
H7H31_RS04140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H7H31_RS04145	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H7H31_RS04160	COG0438	transferase activity, transferring glycosyl groups
H7H31_RS04165	COG1560	Kdo2-lipid A biosynthetic process
H7H31_RS04185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7H31_RS04240	COG0454	-acetyltransferase
H7H31_RS04240	COG0456	acetyltransferase
H7H31_RS04250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7H31_RS04295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7H31_RS04295	COG0515	serine threonine protein kinase
H7H31_RS04300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7H31_RS04305	COG1648	precorrin-2 dehydrogenase activity
H7H31_RS04305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7H31_RS04310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7H31_RS04325	COG1464	Belongs to the NlpA lipoprotein family
H7H31_RS04330	COG2011	ABC-type metal ion transport system permease component
H7H31_RS04335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7H31_RS04340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7H31_RS04375	COG0584	glycerophosphoryl diester phosphodiesterase
H7H31_RS04380	COG0204	Acyl-transferase
H7H31_RS04380	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS04395	COG0477	Major facilitator Superfamily
H7H31_RS04405	COG0165	Argininosuccinate lyase
H7H31_RS04410	COG0137	argininosuccinate synthase activity
H7H31_RS04450	COG3903	Transcriptional regulator
H7H31_RS04450	COG3629	intracellular signal transduction
H7H31_RS04465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7H31_RS04480	COG0077	Prephenate dehydratase
H7H31_RS04485	COG1438	arginine binding
H7H31_RS04490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7H31_RS04495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7H31_RS04500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7H31_RS04505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7H31_RS04560	COG1280	lysine exporter protein (LysE YggA)
H7H31_RS04580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7H31_RS04595	COG1649	PFAM Uncharacterised BCR, COG1649
H7H31_RS04655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7H31_RS04655	COG0072	phenylalanine-tRNA ligase activity
H7H31_RS04660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7H31_RS04665	COG5002	protein histidine kinase activity
H7H31_RS04670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7H31_RS04675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7H31_RS04680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7H31_RS04695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7H31_RS04745	COG0531	amino acid
H7H31_RS04785	COG4175	Glycine betaine
H7H31_RS04785	COG3448	diguanylate cyclase activity
H7H31_RS04790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7H31_RS04810	COG0805	protein transport
H7H31_RS04815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7H31_RS04845	COG0545	Peptidyl-prolyl cis-trans isomerase
H7H31_RS04850	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H7H31_RS04860	COG1609	Transcriptional regulator
H7H31_RS04870	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H7H31_RS04880	COG4122	O-methyltransferase activity
H7H31_RS04885	COG1222	aaa ATPase
H7H31_RS04905	COG0517	IMP dehydrogenase activity
H7H31_RS04905	COG1994	Peptidase M50
H7H31_RS04915	COG2197	response regulator
H7H31_RS04930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7H31_RS04935	COG1410	methionine synthase
H7H31_RS04935	COG0646	methionine synthase
H7H31_RS04940	COG1414	Transcriptional regulator
H7H31_RS04945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7H31_RS04950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7H31_RS04955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7H31_RS04970	COG0215	cysteine-tRNA ligase activity
H7H31_RS04990	COG0598	Magnesium transport protein CorA
H7H31_RS05000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS05005	COG0667	Aldo Keto reductase
H7H31_RS05010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7H31_RS05035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7H31_RS05085	COG0297	glycogen (starch) synthase activity
H7H31_RS05095	COG0728	peptidoglycan biosynthetic process
H7H31_RS05105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7H31_RS05110	COG0297	glycogen (starch) synthase activity
H7H31_RS05160	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H7H31_RS05165	COG2149	membrane
H7H31_RS05185	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS05195	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS05225	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS05265	COG2851	Citrate transporter
H7H31_RS05270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7H31_RS05275	COG2188	Transcriptional regulator
H7H31_RS05310	COG1725	Transcriptional regulator
H7H31_RS05315	COG0456	acetyltransferase
H7H31_RS05345	COG0778	Nitroreductase
H7H31_RS05355	COG0745	RESPONSE REGULATOR receiver
H7H31_RS05365	COG0019	diaminopimelate decarboxylase activity
H7H31_RS05400	COG1959	2 iron, 2 sulfur cluster binding
H7H31_RS05405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7H31_RS05410	COG0587	DNA-directed DNA polymerase activity
H7H31_RS05430	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS05445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7H31_RS05445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7H31_RS05450	COG2301	Belongs to the HpcH HpaI aldolase family
H7H31_RS05460	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS05465	COG0688	phosphatidylethanolamine metabolic process
H7H31_RS05475	COG1929	Belongs to the glycerate kinase type-1 family
H7H31_RS05480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7H31_RS05505	COG1652	LysM domain
H7H31_RS05535	COG0483	inositol monophosphate 1-phosphatase activity
H7H31_RS05555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7H31_RS05575	COG0405	Gamma-glutamyltransferase
H7H31_RS05585	COG0765	amino acid transport
H7H31_RS05590	COG0765	amino acid transport
H7H31_RS05595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7H31_RS05600	COG1126	abc transporter atp-binding protein
H7H31_RS05620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7H31_RS05625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7H31_RS05650	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS05655	COG3321	synthase
H7H31_RS05655	COG0604	alcohol dehydrogenase
H7H31_RS05660	COG0604	alcohol dehydrogenase
H7H31_RS05660	COG3321	synthase
H7H31_RS05685	COG3321	synthase
H7H31_RS05685	COG0604	alcohol dehydrogenase
H7H31_RS05720	COG0789	Transcriptional regulator
H7H31_RS05735	COG1940	carbohydrate kinase activity
H7H31_RS05755	COG2188	Transcriptional regulator
H7H31_RS05760	COG0800	Aldolase
H7H31_RS05785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7H31_RS05790	COG1414	Transcriptional regulator
H7H31_RS05800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7H31_RS05800	COG0515	serine threonine protein kinase
H7H31_RS05820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7H31_RS05840	COG2233	PERMEase
H7H31_RS05855	COG2351	hydroxyisourate hydrolase activity
H7H31_RS05880	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS05885	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS05890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7H31_RS05895	COG2197	response regulator
H7H31_RS05905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS05910	COG0598	Magnesium transport protein CorA
H7H31_RS05940	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7H31_RS05945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7H31_RS05950	COG2192	nodulation
H7H31_RS05965	COG0859	PFAM glycosyl transferase family 9
H7H31_RS05975	COG0297	glycogen (starch) synthase activity
H7H31_RS05980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7H31_RS05985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7H31_RS05985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7H31_RS05990	COG0859	PFAM glycosyl transferase family 9
H7H31_RS06015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS06025	COG3540	Alkaline phosphatase
H7H31_RS06040	COG3220	belongs to the UPF0276 family
H7H31_RS06055	COG2252	PERMEase
H7H31_RS06060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7H31_RS06075	COG3835	regulator
H7H31_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS06115	COG0028	Belongs to the TPP enzyme family
H7H31_RS06135	COG1278	Cold shock
H7H31_RS06140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7H31_RS06185	COG1162	GTPase activity
H7H31_RS06215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7H31_RS06225	COG0175	sulfate reduction
H7H31_RS06230	COG0529	Catalyzes the synthesis of activated sulfate
H7H31_RS06250	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7H31_RS06255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7H31_RS06280	COG1247	-acetyltransferase
H7H31_RS06310	COG1175	transmembrane transport
H7H31_RS06340	COG0583	DNA-binding transcription factor activity
H7H31_RS06345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7H31_RS06360	COG2197	response regulator
H7H31_RS06370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7H31_RS06375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7H31_RS06420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7H31_RS06425	COG3220	belongs to the UPF0276 family
H7H31_RS06440	COG3253	May function as heme-dependent peroxidase
H7H31_RS06445	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7H31_RS06465	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7H31_RS06470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7H31_RS06490	COG0183	Belongs to the thiolase family
H7H31_RS06495	COG1024	Enoyl-CoA hydratase
H7H31_RS06495	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS06515	COG0531	amino acid
H7H31_RS06520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7H31_RS06525	COG4214	carbohydrate transport
H7H31_RS06535	COG4213	ABC transporter substrate-binding protein
H7H31_RS06540	COG1940	carbohydrate kinase activity
H7H31_RS06545	COG0395	ABC-type sugar transport system, permease component
H7H31_RS06550	COG1175	transmembrane transport
H7H31_RS06555	COG1653	transport
H7H31_RS06560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7H31_RS06580	COG2226	methyltransferase
H7H31_RS06590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7H31_RS06595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7H31_RS06600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS06605	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS06615	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS06635	COG0477	Major facilitator Superfamily
H7H31_RS06650	COG1024	Enoyl-CoA hydratase
H7H31_RS06655	COG0531	amino acid
H7H31_RS06660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7H31_RS06670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7H31_RS06680	COG2040	homocysteine
H7H31_RS06710	COG1799	cell septum assembly
H7H31_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS06725	COG2264	protein methyltransferase activity
H7H31_RS06735	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H7H31_RS06760	COG0583	DNA-binding transcription factor activity
H7H31_RS06765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS06775	COG0494	nUDIX hydrolase
H7H31_RS06785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7H31_RS06790	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7H31_RS06800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7H31_RS06820	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
H7H31_RS06870	COG1201	RNA secondary structure unwinding
H7H31_RS06875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7H31_RS06880	COG0531	amino acid
H7H31_RS06915	COG0569	domain protein
H7H31_RS06965	COG1136	(ABC) transporter
H7H31_RS06965	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7H31_RS06970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H7H31_RS06975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7H31_RS06980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7H31_RS06995	COG0756	dUTP diphosphatase activity
H7H31_RS07020	COG2205	protein histidine kinase activity
H7H31_RS07025	COG0745	RESPONSE REGULATOR receiver
H7H31_RS07035	COG0483	inositol monophosphate 1-phosphatase activity
H7H31_RS07040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7H31_RS07075	COG1435	thymidine kinase activity
H7H31_RS07090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS07090	COG0045	succinate-CoA ligase (ADP-forming) activity
H7H31_RS07090	COG1042	CoA-binding domain protein
H7H31_RS07095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7H31_RS07110	COG0612	Peptidase, M16
H7H31_RS07115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7H31_RS07125	COG0372	Belongs to the citrate synthase family
H7H31_RS07130	COG0372	Belongs to the citrate synthase family
H7H31_RS07140	COG3290	protein histidine kinase activity
H7H31_RS07145	COG4565	transcriptional regulatory protein
H7H31_RS07150	COG0187	DNA topoisomerase II activity
H7H31_RS07165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7H31_RS07170	COG2186	Transcriptional regulator
H7H31_RS07175	COG1131	(ABC) transporter
H7H31_RS07190	COG0514	ATP-dependent DNA helicase (RecQ)
H7H31_RS07205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7H31_RS07220	COG0488	(ABC) transporter
H7H31_RS07245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7H31_RS07250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7H31_RS07255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7H31_RS07285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7H31_RS07300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7H31_RS07310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7H31_RS07330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7H31_RS07335	COG2358	TRAP transporter, solute receptor (TAXI family
H7H31_RS07350	COG2205	protein histidine kinase activity
H7H31_RS07360	COG1126	abc transporter atp-binding protein
H7H31_RS07365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7H31_RS07370	COG0765	amino acid transport
H7H31_RS07375	COG0765	amino acid transport
H7H31_RS07380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7H31_RS07390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7H31_RS07395	COG2137	regulation of response to DNA damage stimulus
H7H31_RS07405	COG0628	permease
H7H31_RS07435	COG1201	RNA secondary structure unwinding
H7H31_RS07440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7H31_RS07445	COG0783	Belongs to the Dps family
H7H31_RS07450	COG1396	sequence-specific DNA binding
H7H31_RS07455	COG1058	Belongs to the CinA family
H7H31_RS07455	COG1546	Belongs to the CinA family
H7H31_RS07465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7H31_RS07475	COG1674	ftsk spoiiie
H7H31_RS07485	COG3437	response regulator, receiver
H7H31_RS07485	COG3850	Histidine kinase
H7H31_RS07485	COG4999	Histidine kinase
H7H31_RS07485	COG2205	protein histidine kinase activity
H7H31_RS07520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7H31_RS07525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7H31_RS07530	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H7H31_RS07550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7H31_RS07555	COG0612	Peptidase, M16
H7H31_RS07560	COG1185	polyribonucleotide nucleotidyltransferase activity
H7H31_RS07565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7H31_RS07575	COG1674	ftsk spoiiie
H7H31_RS07590	COG1404	Belongs to the peptidase S8 family
H7H31_RS07605	COG1404	Belongs to the peptidase S8 family
H7H31_RS07610	COG3266	domain, Protein
H7H31_RS07635	COG0455	bacterial-type flagellum organization
H7H31_RS07645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7H31_RS07650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7H31_RS07660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7H31_RS07675	COG0779	Required for maturation of 30S ribosomal subunits
H7H31_RS07695	COG0442	prolyl-tRNA aminoacylation
H7H31_RS07710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7H31_RS07715	COG0750	zinc metalloprotease
H7H31_RS07720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7H31_RS07730	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS07735	COG2508	Transcriptional regulator
H7H31_RS07770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7H31_RS07780	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS07790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7H31_RS07795	COG1136	(ABC) transporter
H7H31_RS07805	COG3842	ATPase activity
H7H31_RS07820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7H31_RS07830	COG0233	cytoplasmic translational termination
H7H31_RS07835	COG0528	UMP kinase activity
H7H31_RS07840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7H31_RS07845	COG0052	Belongs to the universal ribosomal protein uS2 family
H7H31_RS07860	COG1191	sigma factor activity
H7H31_RS07895	COG0792	nuclease activity
H7H31_RS07915	COG0681	Belongs to the peptidase S26 family
H7H31_RS07920	COG0681	Belongs to the peptidase S26 family
H7H31_RS07930	COG0335	large ribosomal subunit rRNA binding
H7H31_RS07935	COG0336	Belongs to the RNA methyltransferase TrmD family
H7H31_RS07940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7H31_RS07945	COG1837	Belongs to the UPF0109 family
H7H31_RS07950	COG0228	four-way junction DNA binding
H7H31_RS07960	COG0442	prolyl-tRNA aminoacylation
H7H31_RS07970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7H31_RS08015	COG0477	Major facilitator Superfamily
H7H31_RS08030	COG1254	Belongs to the acylphosphatase family
H7H31_RS08035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7H31_RS08040	COG0571	ribonuclease III activity
H7H31_RS08045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7H31_RS08060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7H31_RS08065	COG0742	ribosomal rna small subunit methyltransferase
H7H31_RS08075	COG1461	Dihydroxyacetone kinase
H7H31_RS08080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7H31_RS08085	COG0351	phosphomethylpyrimidine kinase
H7H31_RS08105	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7H31_RS08110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7H31_RS08120	COG1920	GTP binding
H7H31_RS08130	COG0776	regulation of translation
H7H31_RS08140	COG0066	3-isopropylmalate dehydratase activity
H7H31_RS08145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7H31_RS08150	COG1414	Transcriptional regulator
H7H31_RS08180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7H31_RS08185	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7H31_RS08195	COG5002	protein histidine kinase activity
H7H31_RS08200	COG2018	Roadblock/LC7 domain
H7H31_RS08220	COG2018	Roadblock/LC7 domain
H7H31_RS08240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7H31_RS08250	COG2353	YceI-like domain
H7H31_RS08255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7H31_RS08260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7H31_RS08265	COG0473	3-isopropylmalate dehydrogenase activity
H7H31_RS08275	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS08280	COG0506	proline dehydrogenase activity
H7H31_RS08295	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7H31_RS08310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7H31_RS08315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7H31_RS08320	COG0440	acetolactate synthase activity
H7H31_RS08340	COG0667	Aldo Keto reductase
H7H31_RS08350	COG2133	pyrroloquinoline quinone binding
H7H31_RS08355	COG2197	response regulator
H7H31_RS08365	COG1078	dGTPase activity
H7H31_RS08370	COG2409	Drug exporters of the RND superfamily
H7H31_RS08375	COG3511	phospholipase C
H7H31_RS08385	COG2814	Major facilitator Superfamily
H7H31_RS08400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7H31_RS08410	COG0154	amidase activity
H7H31_RS08415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7H31_RS08430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7H31_RS08445	COG1611	Belongs to the LOG family
H7H31_RS08450	COG0482	sulfurtransferase activity
H7H31_RS08470	COG3903	Transcriptional regulator
H7H31_RS08470	COG3629	intracellular signal transduction
H7H31_RS08495	COG2860	membrane
H7H31_RS08500	COG4608	Belongs to the ABC transporter superfamily
H7H31_RS08505	COG0444	Belongs to the ABC transporter superfamily
H7H31_RS08540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7H31_RS08545	COG0509	glycine decarboxylation via glycine cleavage system
H7H31_RS08550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7H31_RS08555	COG1760	l-serine dehydratase
H7H31_RS08580	COG4941	Belongs to the sigma-70 factor family
H7H31_RS08595	COG2814	Major facilitator Superfamily
H7H31_RS08615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7H31_RS08615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7H31_RS08635	COG0492	ferredoxin-NADP+ reductase activity
H7H31_RS08645	COG3118	belongs to the thioredoxin family
H7H31_RS08715	COG1132	(ABC) transporter
H7H31_RS08720	COG1132	(ABC) transporter
H7H31_RS08740	COG4221	oxidoreductase activity
H7H31_RS08770	COG0058	SHG alpha-glucan phosphorylase activity
H7H31_RS08790	COG0596	Alpha beta hydrolase
H7H31_RS08795	COG1733	regulation of RNA biosynthetic process
H7H31_RS08800	COG0366	Alpha amylase catalytic
H7H31_RS08815	COG3281	Trehalose synthase
H7H31_RS08820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7H31_RS08825	COG1301	dicarboxylic acid transport
H7H31_RS08830	COG3290	protein histidine kinase activity
H7H31_RS08835	COG4565	transcriptional regulatory protein
H7H31_RS08850	COG1175	transmembrane transport
H7H31_RS08855	COG3833	ABC-type maltose transport systems, permease component
H7H31_RS08865	COG0702	epimerase
H7H31_RS08905	COG0205	6-phosphofructokinase activity
H7H31_RS08910	COG0857	belongs to the CobB CobQ family
H7H31_RS08910	COG0280	phosphate acetyltransferase
H7H31_RS08915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7H31_RS08960	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7H31_RS08960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7H31_RS09015	COG2205	protein histidine kinase activity
H7H31_RS09020	COG0745	RESPONSE REGULATOR receiver
H7H31_RS09035	COG0183	Belongs to the thiolase family
H7H31_RS09090	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H7H31_RS09105	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS09135	COG4585	Histidine kinase
H7H31_RS09140	COG2197	response regulator
H7H31_RS09160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7H31_RS09165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7H31_RS09170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7H31_RS09175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7H31_RS09180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7H31_RS09185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7H31_RS09190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7H31_RS09210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7H31_RS09215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7H31_RS09225	COG2890	protein-(glutamine-N5) methyltransferase activity
H7H31_RS09230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7H31_RS09235	COG0254	rRNA binding
H7H31_RS09240	COG1316	TRANSCRIPTIONal
H7H31_RS09250	COG0083	homoserine kinase activity
H7H31_RS09255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7H31_RS09260	COG0460	homoserine dehydrogenase
H7H31_RS09265	COG0019	diaminopimelate decarboxylase activity
H7H31_RS09270	COG0018	arginyl-trna synthetase
H7H31_RS09310	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7H31_RS09330	COG1674	ftsk spoiiie
H7H31_RS09370	COG1051	belongs to the nudix hydrolase family
H7H31_RS09380	COG2186	Transcriptional regulator
H7H31_RS09420	COG0477	Major facilitator Superfamily
H7H31_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS09430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7H31_RS09470	COG0667	Aldo Keto reductase
H7H31_RS09500	COG1309	transcriptional regulator
H7H31_RS09505	COG2409	Drug exporters of the RND superfamily
H7H31_RS09540	COG0604	alcohol dehydrogenase
H7H31_RS09540	COG3321	synthase
H7H31_RS09560	COG2197	response regulator
H7H31_RS09575	COG3540	Alkaline phosphatase
H7H31_RS09590	COG0583	DNA-binding transcription factor activity
H7H31_RS09605	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7H31_RS09610	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7H31_RS09610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7H31_RS09635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7H31_RS09655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7H31_RS09670	COG2226	methyltransferase
H7H31_RS09680	COG2409	Drug exporters of the RND superfamily
H7H31_RS09685	COG0702	epimerase
H7H31_RS09690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7H31_RS09755	COG2318	DinB family
H7H31_RS09830	COG2409	Drug exporters of the RND superfamily
H7H31_RS09845	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7H31_RS09850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7H31_RS09855	COG2409	Drug exporters of the RND superfamily
H7H31_RS09860	COG4585	Histidine kinase
H7H31_RS09865	COG2197	response regulator
H7H31_RS09875	COG1733	regulation of RNA biosynthetic process
H7H31_RS09900	COG0745	RESPONSE REGULATOR receiver
H7H31_RS09905	COG2205	protein histidine kinase activity
H7H31_RS09910	COG0567	Dehydrogenase, E1 component
H7H31_RS09910	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7H31_RS09950	COG2255	four-way junction helicase activity
H7H31_RS09985	COG0778	Nitroreductase
H7H31_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS10000	COG3321	synthase
H7H31_RS10000	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS10000	COG0300	oxidoreductase activity
H7H31_RS10000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS10040	COG0604	alcohol dehydrogenase
H7H31_RS10045	COG0281	malic enzyme
H7H31_RS10055	COG0765	amino acid transport
H7H31_RS10060	COG1126	abc transporter atp-binding protein
H7H31_RS10065	COG4106	trans-aconitate 2-methyltransferase activity
H7H31_RS10110	COG0326	Molecular chaperone. Has ATPase activity
H7H31_RS10125	COG0598	Magnesium transport protein CorA
H7H31_RS10135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7H31_RS10140	COG2066	Belongs to the glutaminase family
H7H31_RS10185	COG1597	lipid kinase activity
H7H31_RS10200	COG1309	transcriptional regulator
H7H31_RS10205	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS10210	COG1472	Belongs to the glycosyl hydrolase 3 family
H7H31_RS10215	COG0395	ABC-type sugar transport system, permease component
H7H31_RS10220	COG1175	transmembrane transport
H7H31_RS10225	COG2182	Extracellular solute-binding protein
H7H31_RS10230	COG2188	Transcriptional regulator
H7H31_RS10240	COG1966	Carbon starvation protein
H7H31_RS10255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7H31_RS10265	COG0242	peptide deformylase activity
H7H31_RS10280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7H31_RS10280	COG2199	diguanylate cyclase activity
H7H31_RS10290	COG1595	DNA-templated transcription, initiation
H7H31_RS10300	COG2135	peptidase activity
H7H31_RS10310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7H31_RS10330	COG0483	inositol monophosphate 1-phosphatase activity
H7H31_RS10340	COG0753	catalase activity
H7H31_RS10370	COG1615	UPF0182 protein
H7H31_RS10380	COG3480	Lon protease (S16) C-terminal proteolytic domain
H7H31_RS10435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7H31_RS10470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7H31_RS10475	COG1074	ATP-dependent DNA helicase activity
H7H31_RS10555	COG4172	Belongs to the ABC transporter superfamily
H7H31_RS10615	COG0596	Alpha beta hydrolase
H7H31_RS10625	COG1432	Conserved Protein
H7H31_RS10635	COG2095	MarC family integral membrane protein
H7H31_RS10640	COG0613	PHP domain protein
H7H31_RS10650	COG2814	Major facilitator Superfamily
H7H31_RS10660	COG0598	Magnesium transport protein CorA
H7H31_RS10705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7H31_RS10710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7H31_RS10720	COG1595	DNA-templated transcription, initiation
H7H31_RS10735	COG1024	Enoyl-CoA hydratase
H7H31_RS10740	COG0519	Catalyzes the synthesis of GMP from XMP
H7H31_RS10750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7H31_RS10755	COG1611	Belongs to the LOG family
H7H31_RS10760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7H31_RS10805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7H31_RS10830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7H31_RS10835	COG0747	negative chemotaxis
H7H31_RS10850	COG4608	Belongs to the ABC transporter superfamily
H7H31_RS10865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS10920	COG4608	Belongs to the ABC transporter superfamily
H7H31_RS10925	COG0444	Belongs to the ABC transporter superfamily
H7H31_RS10930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7H31_RS10935	COG0601	transmembrane transport
H7H31_RS10995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS11000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS11035	COG4608	Belongs to the ABC transporter superfamily
H7H31_RS11040	COG0444	Belongs to the ABC transporter superfamily
H7H31_RS11045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7H31_RS11050	COG0601	transmembrane transport
H7H31_RS11060	COG1217	gtp-binding protein TYPA
H7H31_RS11125	COG0142	geranyltranstransferase activity
H7H31_RS11130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7H31_RS11145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7H31_RS11165	COG4941	Belongs to the sigma-70 factor family
H7H31_RS11180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7H31_RS11200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7H31_RS11215	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS11225	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS11245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7H31_RS11255	COG2814	Major facilitator Superfamily
H7H31_RS11280	COG0012	GTP binding
H7H31_RS11295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7H31_RS11310	COG1570	exodeoxyribonuclease VII activity
H7H31_RS11320	COG1722	exodeoxyribonuclease VII activity
H7H31_RS11325	COG0778	Nitroreductase
H7H31_RS11350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H7H31_RS11350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H7H31_RS11360	COG0114	fumarate hydratase activity
H7H31_RS11370	COG2264	protein methyltransferase activity
H7H31_RS11400	COG1136	(ABC) transporter
H7H31_RS11420	COG0450	alkyl hydroperoxide reductase
H7H31_RS11425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7H31_RS11440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7H31_RS11445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7H31_RS11450	COG0667	Aldo Keto reductase
H7H31_RS11455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7H31_RS11515	COG2894	cell division
H7H31_RS11555	COG1473	amidohydrolase
H7H31_RS11580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7H31_RS11625	COG1309	transcriptional regulator
H7H31_RS11660	COG2610	gluconate transmembrane transporter activity
H7H31_RS11665	COG0251	oxidation-reduction process
H7H31_RS11670	COG1414	Transcriptional regulator
H7H31_RS11685	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H7H31_RS11715	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H7H31_RS11725	COG2814	Major facilitator Superfamily
H7H31_RS11735	COG1063	alcohol dehydrogenase
H7H31_RS11740	COG1331	Highly conserved protein containing a thioredoxin domain
H7H31_RS11770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7H31_RS11780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7H31_RS11795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7H31_RS11825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7H31_RS11870	COG2161	toxin-antitoxin pair type II binding
H7H31_RS11890	COG0577	efflux transmembrane transporter activity
H7H31_RS11895	COG1136	(ABC) transporter
H7H31_RS11900	COG0477	Major facilitator Superfamily
H7H31_RS11955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7H31_RS11960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7H31_RS11970	COG0583	DNA-binding transcription factor activity
H7H31_RS11980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7H31_RS11985	COG0193	aminoacyl-tRNA hydrolase activity
H7H31_RS12000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7H31_RS12010	COG1309	transcriptional regulator
H7H31_RS12025	COG4106	trans-aconitate 2-methyltransferase activity
H7H31_RS12030	COG1846	Transcriptional regulator
H7H31_RS12035	COG2197	response regulator
H7H31_RS12045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7H31_RS12080	COG0488	(ABC) transporter
H7H31_RS12085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7H31_RS12090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7H31_RS12095	COG0084	hydrolase, TatD family'
H7H31_RS12125	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
H7H31_RS12145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS12170	COG0747	negative chemotaxis
H7H31_RS12200	COG2409	Drug exporters of the RND superfamily
H7H31_RS12210	COG0793	Belongs to the peptidase S41A family
H7H31_RS12210	COG4946	Tricorn protease homolog
H7H31_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS12225	COG2267	carboxylic ester hydrolase activity
H7H31_RS12230	COG2072	flavoprotein involved in K transport
H7H31_RS12240	COG0708	Exodeoxyribonuclease III
H7H31_RS12255	COG3173	Aminoglycoside phosphotransferase
H7H31_RS12275	COG0583	DNA-binding transcription factor activity
H7H31_RS12285	COG0154	amidase activity
H7H31_RS12290	COG3795	YCII-related domain
H7H31_RS12295	COG4941	Belongs to the sigma-70 factor family
H7H31_RS12315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS12320	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7H31_RS12325	COG0315	cyclic pyranopterin monophosphate synthase activity
H7H31_RS12335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7H31_RS12340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7H31_RS12350	COG3263	regulation of cellular component size
H7H31_RS12365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7H31_RS12375	COG1970	mechanosensitive ion channel activity
H7H31_RS12385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7H31_RS12390	COG3191	aminopeptidase activity
H7H31_RS12405	COG1846	Transcriptional regulator
H7H31_RS12425	COG1309	transcriptional regulator
H7H31_RS12455	COG2226	methyltransferase
H7H31_RS12460	COG0798	PFAM Bile acid sodium symporter
H7H31_RS12465	COG0640	Transcriptional regulator
H7H31_RS12470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7H31_RS12485	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7H31_RS12495	COG0514	ATP-dependent DNA helicase (RecQ)
H7H31_RS12505	COG0789	Transcriptional regulator
H7H31_RS12525	COG1686	Belongs to the peptidase S11 family
H7H31_RS12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7H31_RS12560	COG3708	Transcriptional regulator
H7H31_RS12560	COG2207	Transcriptional regulator
H7H31_RS12565	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H7H31_RS12580	COG0531	amino acid
H7H31_RS12625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7H31_RS12625	COG0515	serine threonine protein kinase
H7H31_RS12655	COG2197	response regulator
H7H31_RS12665	COG1309	transcriptional regulator
H7H31_RS12690	COG2072	flavoprotein involved in K transport
H7H31_RS12715	COG0515	serine threonine protein kinase
H7H31_RS12750	COG1077	Cell shape determining protein MreB Mrl
H7H31_RS12760	COG0516	GMP reductase activity
H7H31_RS12775	COG1595	DNA-templated transcription, initiation
H7H31_RS12780	COG2197	response regulator
H7H31_RS12790	COG0583	DNA-binding transcription factor activity
H7H31_RS12800	COG4221	oxidoreductase activity
H7H31_RS12810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7H31_RS12855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7H31_RS12875	COG0802	atpase or kinase
H7H31_RS12885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7H31_RS12895	COG0736	holo-[acyl-carrier-protein] synthase activity
H7H31_RS12900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7H31_RS12905	COG1072	(Pantothenic acid kinase))
H7H31_RS12995	COG0702	epimerase
H7H31_RS13020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7H31_RS13025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7H31_RS13030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7H31_RS13035	COG0488	(ABC) transporter
H7H31_RS13045	COG0438	transferase activity, transferring glycosyl groups
H7H31_RS13050	COG0101	tRNA pseudouridine synthase activity
H7H31_RS13055	COG0203	ribosomal protein L17
H7H31_RS13060	COG0202	RNA polymerase activity
H7H31_RS13065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7H31_RS13070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7H31_RS13075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7H31_RS13080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7H31_RS13090	COG0563	adenylate kinase activity
H7H31_RS13100	COG0200	Binds to the 23S rRNA
H7H31_RS13110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7H31_RS13115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7H31_RS13120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7H31_RS13125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7H31_RS13130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7H31_RS13135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7H31_RS13140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7H31_RS13145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7H31_RS13150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7H31_RS13155	COG0255	Belongs to the universal ribosomal protein uL29 family
H7H31_RS13160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7H31_RS13165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7H31_RS13170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7H31_RS13175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7H31_RS13180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7H31_RS13185	COG0089	rRNA binding
H7H31_RS13190	COG0088	Forms part of the polypeptide exit tunnel
H7H31_RS13195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7H31_RS13200	COG0051	transcription antitermination factor activity, RNA binding
H7H31_RS13215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7H31_RS13220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7H31_RS13225	COG0049	tRNA binding
H7H31_RS13230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7H31_RS13240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7H31_RS13245	COG0085	RNA polymerase activity
H7H31_RS13250	COG0222	ribosome binding
H7H31_RS13255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7H31_RS13265	COG0081	regulation of translation
H7H31_RS13270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7H31_RS13275	COG0250	Participates in transcription elongation, termination and antitermination
H7H31_RS13290	COG0436	Aminotransferase
H7H31_RS13295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7H31_RS13310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7H31_RS13330	COG2030	dehydratase
H7H31_RS13335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7H31_RS13350	COG0402	S-adenosylhomocysteine deaminase activity
H7H31_RS13360	COG0702	epimerase
H7H31_RS13380	COG1666	GTP binding
H7H31_RS13390	COG3304	Inner membrane component domain
H7H31_RS13395	COG0501	Belongs to the peptidase M48B family
H7H31_RS13400	COG1007	ATP synthesis coupled electron transport
H7H31_RS13410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7H31_RS13415	COG0713	ATP synthesis coupled electron transport
H7H31_RS13425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7H31_RS13430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7H31_RS13435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7H31_RS13440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7H31_RS13450	COG4585	Histidine kinase
H7H31_RS13455	COG4585	Histidine kinase
H7H31_RS13465	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7H31_RS13465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7H31_RS13470	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7H31_RS13475	COG1733	regulation of RNA biosynthetic process
H7H31_RS13480	COG0702	epimerase
H7H31_RS13515	COG2234	aminopeptidase activity
H7H31_RS13515	COG4935	Belongs to the peptidase S8 family
H7H31_RS13540	COG0142	geranyltranstransferase activity
H7H31_RS13545	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7H31_RS13560	COG1007	ATP synthesis coupled electron transport
H7H31_RS13570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7H31_RS13575	COG0713	ATP synthesis coupled electron transport
H7H31_RS13580	COG0839	Belongs to the complex I subunit 6 family
H7H31_RS13585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7H31_RS13590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7H31_RS13595	COG1034	ATP synthesis coupled electron transport
H7H31_RS13600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H7H31_RS13610	COG0649	NAD binding
H7H31_RS13615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7H31_RS13620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7H31_RS13690	COG2226	methyltransferase
H7H31_RS13700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H7H31_RS13710	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H7H31_RS13715	COG1278	Cold shock
H7H31_RS13725	COG1309	transcriptional regulator
H7H31_RS13730	COG1301	dicarboxylic acid transport
H7H31_RS13745	COG1573	uracil-dna glycosylase
H7H31_RS13750	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H7H31_RS13760	COG0163	prenyltransferase activity
H7H31_RS13765	COG0109	protoheme IX farnesyltransferase activity
H7H31_RS13770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7H31_RS13795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7H31_RS13800	COG1333	cytochrome c biogenesis protein
H7H31_RS13820	COG0406	alpha-ribazole phosphatase activity
H7H31_RS13825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7H31_RS13845	COG0248	Ppx GppA phosphatase
H7H31_RS13860	COG1131	(ABC) transporter
H7H31_RS13910	COG3629	intracellular signal transduction
H7H31_RS13910	COG3903	Transcriptional regulator
H7H31_RS13915	COG0596	Alpha beta hydrolase
H7H31_RS13975	COG1742	UPF0060 membrane protein
H7H31_RS13985	COG0667	Aldo Keto reductase
H7H31_RS14000	COG1733	regulation of RNA biosynthetic process
H7H31_RS14015	COG1690	Belongs to the RtcB family
H7H31_RS14040	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H7H31_RS14045	COG0018	arginyl-trna synthetase
H7H31_RS14080	COG1595	DNA-templated transcription, initiation
H7H31_RS14085	COG1228	amidohydrolase
H7H31_RS14125	COG0113	porphobilinogen synthase activity
H7H31_RS14130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7H31_RS14130	COG1648	precorrin-2 dehydrogenase activity
H7H31_RS14135	COG0181	hydroxymethylbilane synthase activity
H7H31_RS14140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7H31_RS14145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H7H31_RS14195	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7H31_RS14200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7H31_RS14220	COG1846	Transcriptional regulator
H7H31_RS14240	COG1252	NADH dehydrogenase
H7H31_RS14255	COG0584	glycerophosphoryl diester phosphodiesterase
H7H31_RS14280	COG0579	oxidoreductase
H7H31_RS14300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7H31_RS14310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS14375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7H31_RS14395	COG0667	Aldo Keto reductase
H7H31_RS14435	COG1733	regulation of RNA biosynthetic process
H7H31_RS14445	COG1302	Protein conserved in bacteria
H7H31_RS14480	COG0513	Belongs to the DEAD box helicase family
H7H31_RS14555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7H31_RS14565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7H31_RS14575	COG1051	belongs to the nudix hydrolase family
H7H31_RS14620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS14630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7H31_RS14635	COG1595	DNA-templated transcription, initiation
H7H31_RS14655	COG0583	DNA-binding transcription factor activity
H7H31_RS14665	COG3119	arylsulfatase activity
H7H31_RS14675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7H31_RS14680	COG0047	phosphoribosylformylglycinamidine synthase activity
H7H31_RS14685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7H31_RS14710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7H31_RS14725	COG0151	Belongs to the GarS family
H7H31_RS14740	COG1802	Transcriptional regulator
H7H31_RS14745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7H31_RS14755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7H31_RS14770	COG1131	(ABC) transporter
H7H31_RS14775	COG3559	Exporter of polyketide antibiotics
H7H31_RS14790	COG3844	kynureninase activity
H7H31_RS14805	COG0477	Major facilitator Superfamily
H7H31_RS14810	COG0191	fructose-bisphosphate aldolase activity
H7H31_RS14815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7H31_RS14845	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7H31_RS14875	COG0542	response to heat
H7H31_RS14910	COG0789	Transcriptional regulator
H7H31_RS14915	COG0484	heat shock protein binding
H7H31_RS14920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7H31_RS14925	COG0443	Heat shock 70 kDa protein
H7H31_RS14930	COG0247	lactate metabolic process
H7H31_RS14930	COG2181	nitrate reductase activity
H7H31_RS14945	COG4552	Acetyltransferase involved in intracellular survival and related
H7H31_RS14960	COG0717	Belongs to the dCTP deaminase family
H7H31_RS14980	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS14990	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS14995	COG0583	DNA-binding transcription factor activity
H7H31_RS15010	COG0702	epimerase
H7H31_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS15045	COG0604	alcohol dehydrogenase
H7H31_RS15055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H7H31_RS15070	COG1120	ATPase activity
H7H31_RS15075	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS15080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS15090	COG2207	Transcriptional regulator
H7H31_RS15125	COG1401	restriction endodeoxyribonuclease activity
H7H31_RS15135	COG0667	Aldo Keto reductase
H7H31_RS15255	COG1674	ftsk spoiiie
H7H31_RS15310	COG1857	crispr-associated protein
H7H31_RS15390	COG2255	four-way junction helicase activity
H7H31_RS15450	COG3226	Transcriptional regulator
H7H31_RS15480	COG1917	Cupin 2, conserved barrel domain protein
H7H31_RS15480	COG4977	sequence-specific DNA binding
H7H31_RS15490	COG1595	DNA-templated transcription, initiation
H7H31_RS15535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7H31_RS15550	COG0640	Transcriptional regulator
H7H31_RS15610	COG0583	DNA-binding transcription factor activity
H7H31_RS15620	COG2340	Cysteine-rich secretory protein family
H7H31_RS15640	COG3285	dna ligase
H7H31_RS15640	COG1793	dna ligase
H7H31_RS15655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS15675	COG1396	sequence-specific DNA binding
H7H31_RS15675	COG3800	Transcriptional regulator
H7H31_RS15690	COG2226	methyltransferase
H7H31_RS15710	COG2304	oxidoreductase activity
H7H31_RS15715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7H31_RS15740	COG1522	sequence-specific DNA binding
H7H31_RS15750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7H31_RS15775	COG1741	Belongs to the pirin family
H7H31_RS15790	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS15795	COG1362	aminopeptidase activity
H7H31_RS15805	COG3629	intracellular signal transduction
H7H31_RS15805	COG3903	Transcriptional regulator
H7H31_RS15820	COG1595	DNA-templated transcription, initiation
H7H31_RS15865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7H31_RS15885	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7H31_RS15890	COG0022	dehydrogenase e1 component
H7H31_RS15915	COG0515	serine threonine protein kinase
H7H31_RS15920	COG0515	serine threonine protein kinase
H7H31_RS15935	COG3321	synthase
H7H31_RS15935	COG0604	alcohol dehydrogenase
H7H31_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS15940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7H31_RS15975	COG1522	sequence-specific DNA binding
H7H31_RS15985	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS16005	COG2076	Multidrug Resistance protein
H7H31_RS16030	COG3396	Phenylacetate-CoA oxygenase
H7H31_RS16035	COG3460	Phenylacetate-CoA oxygenase
H7H31_RS16040	COG3396	Phenylacetate-CoA oxygenase
H7H31_RS16045	COG2151	metal-sulfur cluster biosynthetic enzyme
H7H31_RS16050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7H31_RS16075	COG1733	regulation of RNA biosynthetic process
H7H31_RS16080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7H31_RS16090	COG1716	ATPase activity
H7H31_RS16095	COG1716	ATPase activity
H7H31_RS16105	COG0772	Belongs to the SEDS family
H7H31_RS16110	COG0768	penicillin binding
H7H31_RS16115	COG0515	serine threonine protein kinase
H7H31_RS16120	COG3764	Sortase (surface protein transpeptidase)
H7H31_RS16125	COG3764	Sortase (surface protein transpeptidase)
H7H31_RS16150	COG0705	Rhomboid family
H7H31_RS16170	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H7H31_RS16175	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7H31_RS16185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7H31_RS16195	COG0745	RESPONSE REGULATOR receiver
H7H31_RS16200	COG2205	protein histidine kinase activity
H7H31_RS16245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7H31_RS16255	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H7H31_RS16260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7H31_RS16265	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7H31_RS16270	COG0592	DNA-directed DNA polymerase activity
H7H31_RS16280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7H31_RS16290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7H31_RS16295	COG0706	membrane insertase activity
H7H31_RS16305	COG0357	Ribosomal RNA small subunit methyltransferase G
H7H31_RS16310	COG1192	Involved in chromosome partitioning
H7H31_RS16325	COG3118	belongs to the thioredoxin family
H7H31_RS16330	COG0492	ferredoxin-NADP+ reductase activity
H7H31_RS16340	COG1595	DNA-templated transcription, initiation
H7H31_RS16345	COG0515	serine threonine protein kinase
H7H31_RS16345	COG2815	serine threonine protein kinase
H7H31_RS16360	COG0617	tRNA 3'-terminal CCA addition
H7H31_RS16380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7H31_RS16405	COG0360	Binds together with S18 to 16S ribosomal RNA
H7H31_RS16410	COG0629	single-stranded DNA binding
H7H31_RS16415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7H31_RS16420	COG0359	binds to the 23S rRNA
H7H31_RS16425	COG0534	Mate efflux family protein
H7H31_RS16430	COG0305	Participates in initiation and elongation during chromosome replication
H7H31_RS16515	COG2814	Major facilitator Superfamily
H7H31_RS16550	COG0626	cystathionine gamma-synthase activity
H7H31_RS16555	COG1950	PFAM Membrane protein of
H7H31_RS16560	COG0662	Cupin 2, conserved barrel domain protein
H7H31_RS16585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7H31_RS16605	COG0504	CTP synthase activity
H7H31_RS16620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7H31_RS16625	COG1609	Transcriptional regulator
H7H31_RS16630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7H31_RS16635	COG1271	oxidase subunit
H7H31_RS16640	COG1294	oxidase, subunit
H7H31_RS16645	COG4988	ABC transporter
H7H31_RS16665	COG0561	phosphatase activity
H7H31_RS16685	COG0501	Belongs to the peptidase M48B family
H7H31_RS16700	COG0789	Transcriptional regulator
H7H31_RS16745	COG1396	sequence-specific DNA binding
H7H31_RS16755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7H31_RS16765	COG2807	transmembrane transport
H7H31_RS16770	COG2186	Transcriptional regulator
H7H31_RS16795	COG1819	glycosyl
H7H31_RS16825	COG0561	phosphatase activity
H7H31_RS16830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7H31_RS16840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7H31_RS16860	COG4209	transmembrane transport
H7H31_RS16865	COG0395	ABC-type sugar transport system, permease component
H7H31_RS16875	COG0673	inositol 2-dehydrogenase activity
H7H31_RS16880	COG2837	iron assimilation
H7H31_RS16885	COG2372	response to copper ion
H7H31_RS16895	COG1999	signal sequence binding
H7H31_RS16930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7H31_RS16940	COG0006	proline dipeptidase activity
H7H31_RS16955	COG0653	protein targeting
H7H31_RS16970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7H31_RS17060	COG2188	Transcriptional regulator
H7H31_RS17065	COG2226	methyltransferase
H7H31_RS17100	COG1595	DNA-templated transcription, initiation
H7H31_RS17120	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS17130	COG0488	(ABC) transporter
H7H31_RS17135	COG0784	Response regulator, receiver
H7H31_RS17190	COG0745	RESPONSE REGULATOR receiver
H7H31_RS17195	COG0477	Major facilitator Superfamily
H7H31_RS17205	COG2353	YceI-like domain
H7H31_RS17225	COG1191	sigma factor activity
H7H31_RS17230	COG1191	sigma factor activity
H7H31_RS17270	COG2226	methyltransferase
H7H31_RS17275	COG3896	Chloramphenicol phosphotransferase-like protein
H7H31_RS17315	COG2197	response regulator
H7H31_RS17325	COG2409	Drug exporters of the RND superfamily
H7H31_RS17345	COG0697	spore germination
H7H31_RS17400	COG0531	amino acid
H7H31_RS17435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7H31_RS17475	COG2084	Dehydrogenase
H7H31_RS17510	COG2362	D-Aminopeptidase
H7H31_RS17565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7H31_RS17585	COG0488	(ABC) transporter
H7H31_RS17600	COG0076	glutamate decarboxylase activity
H7H31_RS17645	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
H7H31_RS17680	COG2318	DinB family
H7H31_RS17705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7H31_RS17710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7H31_RS17730	COG1595	DNA-templated transcription, initiation
H7H31_RS17750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7H31_RS17755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7H31_RS17770	COG1408	metallophosphoesterase
H7H31_RS17790	COG0003	Pfam Anion-transporting ATPase
H7H31_RS17825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7H31_RS17855	COG0596	Alpha beta hydrolase
H7H31_RS17865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7H31_RS17870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7H31_RS17875	COG0659	secondary active sulfate transmembrane transporter activity
H7H31_RS17935	COG1111	helicase
H7H31_RS17935	COG1205	dead DEAH box helicase
H7H31_RS17940	COG1366	Belongs to the anti-sigma-factor antagonist family
H7H31_RS17950	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7H31_RS17960	COG2890	protein-(glutamine-N5) methyltransferase activity
H7H31_RS17970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7H31_RS17970	COG1754	DNA topoisomerase type I activity
H7H31_RS17975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7H31_RS17980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7H31_RS18025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7H31_RS18110	COG0019	diaminopimelate decarboxylase activity
H7H31_RS18125	COG1472	Belongs to the glycosyl hydrolase 3 family
H7H31_RS18130	COG2409	Drug exporters of the RND superfamily
H7H31_RS18135	COG4585	Histidine kinase
H7H31_RS18140	COG2197	response regulator
H7H31_RS18215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS18220	COG2318	DinB family
H7H31_RS18225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7H31_RS18230	COG1595	DNA-templated transcription, initiation
H7H31_RS18250	COG1733	regulation of RNA biosynthetic process
H7H31_RS18275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7H31_RS18285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS18300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7H31_RS18335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7H31_RS18340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7H31_RS18355	COG0477	Major facilitator Superfamily
H7H31_RS18360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7H31_RS18365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7H31_RS18375	COG4770	biotin carboxylase activity
H7H31_RS18400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS18420	COG1077	Cell shape determining protein MreB Mrl
H7H31_RS18425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7H31_RS18425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7H31_RS18435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7H31_RS18440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7H31_RS18445	COG0254	rRNA binding
H7H31_RS18455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7H31_RS18475	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS18480	COG2318	DinB family
H7H31_RS18505	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7H31_RS18515	COG0181	hydroxymethylbilane synthase activity
H7H31_RS18540	COG0789	Transcriptional regulator
H7H31_RS18545	COG0393	Putative heavy-metal-binding
H7H31_RS18560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7H31_RS18565	COG2027	D-alanyl-D-alanine carboxypeptidase
H7H31_RS18595	COG0302	gtp cyclohydrolase
H7H31_RS18620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7H31_RS18625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7H31_RS18635	COG1125	glycine betaine transport
H7H31_RS18635	COG0517	IMP dehydrogenase activity
H7H31_RS18650	COG1732	Glycine betaine
H7H31_RS18660	COG0649	NAD binding
H7H31_RS18675	COG2197	response regulator
H7H31_RS18695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7H31_RS18700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7H31_RS18710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7H31_RS18730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7H31_RS18760	COG0739	heme binding
H7H31_RS18790	COG2205	protein histidine kinase activity
H7H31_RS18795	COG0745	RESPONSE REGULATOR receiver
H7H31_RS18820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7H31_RS18830	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H7H31_RS18855	COG0248	Ppx GppA phosphatase
H7H31_RS18860	COG1082	Xylose isomerase domain protein TIM barrel
H7H31_RS18870	COG0129	dihydroxy-acid dehydratase activity
H7H31_RS18900	COG1324	tolerance protein
H7H31_RS18905	COG1324	tolerance protein
H7H31_RS18965	COG2409	Drug exporters of the RND superfamily
H7H31_RS18970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7H31_RS18975	COG0180	Tryptophanyl-tRNA synthetase
H7H31_RS19035	COG0741	lytic transglycosylase activity
H7H31_RS19040	COG0671	phosphoesterase, PA-phosphatase related
H7H31_RS19045	COG0277	FAD linked oxidase domain protein
H7H31_RS19060	COG1937	Protein conserved in bacteria
H7H31_RS19070	COG0306	phosphate transporter
H7H31_RS19075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7H31_RS19150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7H31_RS19170	COG4977	sequence-specific DNA binding
H7H31_RS19190	COG1595	DNA-templated transcription, initiation
H7H31_RS19195	COG1902	pentaerythritol trinitrate reductase activity
H7H31_RS19205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7H31_RS19225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7H31_RS19240	COG2378	regulation of single-species biofilm formation
H7H31_RS19245	COG1733	regulation of RNA biosynthetic process
H7H31_RS19250	COG2084	Dehydrogenase
H7H31_RS19265	COG4552	Acetyltransferase involved in intracellular survival and related
H7H31_RS19280	COG1490	D-aminoacyl-tRNA deacylase activity
H7H31_RS19285	COG1192	Involved in chromosome partitioning
H7H31_RS19290	COG0354	folic acid binding
H7H31_RS19295	COG0735	belongs to the Fur family
H7H31_RS19305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H7H31_RS19310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS19315	COG3485	protocatechuate 3,4-dioxygenase
H7H31_RS19335	COG2897	thiosulfate sulfurtransferase activity
H7H31_RS19365	COG0745	RESPONSE REGULATOR receiver
H7H31_RS19370	COG1609	Transcriptional regulator
H7H31_RS19375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS19395	COG0583	DNA-binding transcription factor activity
H7H31_RS19430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS19435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7H31_RS19445	COG2205	protein histidine kinase activity
H7H31_RS19455	COG1309	transcriptional regulator
H7H31_RS19475	COG1357	PFAM Pentapeptide repeats (8 copies)
H7H31_RS19500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7H31_RS19505	COG0737	Belongs to the 5'-nucleotidase family
H7H31_RS19510	COG0456	acetyltransferase
H7H31_RS19515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7H31_RS19525	COG0406	alpha-ribazole phosphatase activity
H7H31_RS19525	COG0494	nUDIX hydrolase
H7H31_RS19565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7H31_RS19580	COG0438	transferase activity, transferring glycosyl groups
H7H31_RS19605	COG0588	phosphoglycerate mutase activity
H7H31_RS19625	COG5002	protein histidine kinase activity
H7H31_RS19640	COG1329	Transcriptional regulator
H7H31_RS19645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7H31_RS19650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7H31_RS19660	COG0215	cysteine-tRNA ligase activity
H7H31_RS19665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7H31_RS19675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7H31_RS19685	COG3842	ATPase activity
H7H31_RS19715	COG2188	Transcriptional regulator
H7H31_RS19795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7H31_RS19800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7H31_RS19850	COG0477	Major facilitator Superfamily
H7H31_RS19860	COG0477	Major facilitator Superfamily
H7H31_RS19865	COG0640	Transcriptional regulator
H7H31_RS19890	COG1846	Transcriptional regulator
H7H31_RS19910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7H31_RS19925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS19935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H7H31_RS19940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7H31_RS19960	COG1105	Belongs to the carbohydrate kinase PfkB family
H7H31_RS19995	COG0463	Glycosyl transferase, family 2
H7H31_RS20000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7H31_RS20010	COG1278	Cold shock
H7H31_RS20015	COG0459	protein refolding
H7H31_RS20020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7H31_RS20025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7H31_RS20050	COG3142	Participates in the control of copper homeostasis
H7H31_RS20055	COG0456	acetyltransferase
H7H31_RS20080	COG3973	AAA domain
H7H31_RS20090	COG1061	Type III restriction enzyme res subunit
H7H31_RS20140	COG1120	ATPase activity
H7H31_RS20145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS20150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS20165	COG1278	Cold shock
H7H31_RS20180	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H7H31_RS20185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7H31_RS20195	COG2814	Major facilitator Superfamily
H7H31_RS20225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7H31_RS20235	COG2252	PERMEase
H7H31_RS20280	COG0667	Aldo Keto reductase
H7H31_RS20300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7H31_RS20305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7H31_RS20310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7H31_RS20335	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS20380	COG1487	ribonuclease activity
H7H31_RS20390	COG2890	protein-(glutamine-N5) methyltransferase activity
H7H31_RS20410	COG0247	lactate metabolic process
H7H31_RS20410	COG0277	FAD linked oxidase domain protein
H7H31_RS20440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7H31_RS20455	COG1024	Enoyl-CoA hydratase
H7H31_RS20585	COG1309	transcriptional regulator
H7H31_RS20605	COG0259	pyridoxamine-phosphate oxidase activity
H7H31_RS20620	COG4821	SIS domain
H7H31_RS20630	COG2945	thiolester hydrolase activity
H7H31_RS20630	COG0596	Alpha beta hydrolase
H7H31_RS20640	COG1674	ftsk spoiiie
H7H31_RS20850	COG0515	serine threonine protein kinase
H7H31_RS20850	COG2815	serine threonine protein kinase
H7H31_RS20855	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS20875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7H31_RS20875	COG0519	Catalyzes the synthesis of GMP from XMP
H7H31_RS20920	COG2197	response regulator
H7H31_RS20925	COG0726	polysaccharide deacetylase
H7H31_RS20940	COG1959	2 iron, 2 sulfur cluster binding
H7H31_RS20960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7H31_RS20960	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7H31_RS20975	COG0714	Associated with various cellular activities
H7H31_RS20990	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H7H31_RS20995	COG0045	succinate-CoA ligase (ADP-forming) activity
H7H31_RS21025	COG0138	bifunctional purine biosynthesis protein purh
H7H31_RS21030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7H31_RS21050	COG0039	L-malate dehydrogenase activity
H7H31_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS21075	COG4175	Glycine betaine
H7H31_RS21075	COG0517	IMP dehydrogenase activity
H7H31_RS21080	COG4176	ABC-type proline glycine betaine transport system permease component
H7H31_RS21095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7H31_RS21100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7H31_RS21105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7H31_RS21110	COG0180	Tryptophanyl-tRNA synthetase
H7H31_RS21125	COG3973	AAA domain
H7H31_RS21130	COG1295	ribonuclease BN
H7H31_RS21145	COG1408	metallophosphoesterase
H7H31_RS21160	COG0789	Transcriptional regulator
H7H31_RS21165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7H31_RS21180	COG2009	succinate dehydrogenase
H7H31_RS21450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7H31_RS21450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7H31_RS21480	COG1595	DNA-templated transcription, initiation
H7H31_RS21505	COG2226	methyltransferase
H7H31_RS21510	COG2186	Transcriptional regulator
H7H31_RS21515	COG3265	gluconokinase activity
H7H31_RS21545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7H31_RS21555	COG1216	Glycosyl transferase, family 2
H7H31_RS21570	COG2089	acid synthase
H7H31_RS21580	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H7H31_RS21580	COG1473	amidohydrolase
H7H31_RS21585	COG1744	ABC transporter substrate-binding protein PnrA-like
H7H31_RS21590	COG3845	ABC transporter
H7H31_RS21595	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7H31_RS21600	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7H31_RS21620	COG2814	Major facilitator Superfamily
H7H31_RS21625	COG0583	DNA-binding transcription factor activity
H7H31_RS21640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7H31_RS21665	COG2205	protein histidine kinase activity
H7H31_RS21670	COG0745	RESPONSE REGULATOR receiver
H7H31_RS21675	COG1595	DNA-templated transcription, initiation
H7H31_RS21685	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS21690	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS21705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7H31_RS21735	COG4770	biotin carboxylase activity
H7H31_RS21745	COG0424	maF-like protein
H7H31_RS21755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7H31_RS21765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7H31_RS21770	COG1024	Enoyl-CoA hydratase
H7H31_RS21785	COG2986	histidine ammonia-lyase
H7H31_RS21835	COG2814	Major facilitator Superfamily
H7H31_RS21845	COG2124	cytochrome p450
H7H31_RS21860	COG0148	phosphopyruvate hydratase activity
H7H31_RS21885	COG4977	sequence-specific DNA binding
H7H31_RS21935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7H31_RS21940	COG0577	efflux transmembrane transporter activity
H7H31_RS21945	COG1136	(ABC) transporter
H7H31_RS21955	COG5006	permease, DMT superfamily
H7H31_RS21960	COG0583	DNA-binding transcription factor activity
H7H31_RS22000	COG0183	Belongs to the thiolase family
H7H31_RS22005	COG2755	lipolytic protein G-D-S-L family
H7H31_RS22015	COG0148	phosphopyruvate hydratase activity
H7H31_RS22040	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS22090	COG1476	TRANSCRIPTIONal
H7H31_RS22095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7H31_RS22095	COG2022	thiamine diphosphate biosynthetic process
H7H31_RS22100	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7H31_RS22120	COG2814	Major facilitator Superfamily
H7H31_RS22130	COG2264	protein methyltransferase activity
H7H31_RS22135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7H31_RS22150	COG1228	amidohydrolase
H7H31_RS22180	COG1191	sigma factor activity
H7H31_RS22185	COG1366	Belongs to the anti-sigma-factor antagonist family
H7H31_RS22195	COG3104	oligopeptide transport
H7H31_RS22200	COG0745	RESPONSE REGULATOR receiver
H7H31_RS22205	COG2205	protein histidine kinase activity
H7H31_RS22230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS22265	COG1131	(ABC) transporter
H7H31_RS22280	COG2197	response regulator
H7H31_RS22285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7H31_RS22305	COG1316	TRANSCRIPTIONal
H7H31_RS22320	COG1316	TRANSCRIPTIONal
H7H31_RS22335	COG1316	TRANSCRIPTIONal
H7H31_RS22340	COG1316	TRANSCRIPTIONal
H7H31_RS22365	COG0778	Nitroreductase
H7H31_RS22365	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H7H31_RS22370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7H31_RS22405	COG2340	Cysteine-rich secretory protein family
H7H31_RS22410	COG1620	l-lactate permease
H7H31_RS22415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7H31_RS22420	COG2835	tetraacyldisaccharide 4'-kinase activity
H7H31_RS22430	COG1482	cell wall glycoprotein biosynthetic process
H7H31_RS22440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7H31_RS22440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7H31_RS22440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7H31_RS22445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7H31_RS22470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7H31_RS22475	COG0745	RESPONSE REGULATOR receiver
H7H31_RS22480	COG5000	phosphorelay sensor kinase activity
H7H31_RS22480	COG5002	protein histidine kinase activity
H7H31_RS22485	COG0823	Involved in the tonB-independent uptake of proteins
H7H31_RS22490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7H31_RS22495	COG2197	response regulator
H7H31_RS22500	COG3214	Protein conserved in bacteria
H7H31_RS22505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS22510	COG0653	protein targeting
H7H31_RS22535	COG2902	Dehydrogenase
H7H31_RS22540	COG1595	DNA-templated transcription, initiation
H7H31_RS22550	COG0395	ABC-type sugar transport system, permease component
H7H31_RS22555	COG1175	transmembrane transport
H7H31_RS22560	COG1653	transport
H7H31_RS22570	COG0515	serine threonine protein kinase
H7H31_RS22575	COG0515	serine threonine protein kinase
H7H31_RS22580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H7H31_RS22595	COG2884	Cell division ATP-binding protein ftsE
H7H31_RS22610	COG0793	Belongs to the peptidase S41A family
H7H31_RS22615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7H31_RS22640	COG3973	AAA domain
H7H31_RS22640	COG3973	AAA domain
H7H31_RS22650	COG0776	regulation of translation
H7H31_RS22655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7H31_RS22660	COG1678	Uncharacterized ACR, COG1678
H7H31_RS22670	COG0583	DNA-binding transcription factor activity
H7H31_RS22675	COG2814	Major facilitator Superfamily
H7H31_RS22695	COG1175	transmembrane transport
H7H31_RS22700	COG0395	ABC-type sugar transport system, permease component
H7H31_RS22715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7H31_RS22735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS22735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS22745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS22780	COG0583	DNA-binding transcription factor activity
H7H31_RS22790	COG2855	membrane
H7H31_RS22795	COG0477	Major facilitator Superfamily
H7H31_RS22805	COG3654	unkown
H7H31_RS22820	COG3480	Lon protease (S16) C-terminal proteolytic domain
H7H31_RS22835	COG1174	glycine betaine transport
H7H31_RS22845	COG1174	glycine betaine transport
H7H31_RS22855	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H7H31_RS22865	COG0277	FAD linked oxidase domain protein
H7H31_RS22925	COG1335	isochorismatase
H7H31_RS22935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7H31_RS22945	COG1113	amino acid transport
H7H31_RS22975	COG1234	tRNA 3'-trailer cleavage
H7H31_RS22980	COG1263	PTS System
H7H31_RS22985	COG1263	PTS System
H7H31_RS22990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7H31_RS22995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7H31_RS23005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7H31_RS23030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7H31_RS23035	COG2076	Multidrug Resistance protein
H7H31_RS23040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7H31_RS23055	COG4555	ABC transporter
H7H31_RS23070	COG2733	membrane
H7H31_RS23115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7H31_RS23120	COG0673	inositol 2-dehydrogenase activity
H7H31_RS23140	COG2188	Transcriptional regulator
H7H31_RS23200	COG2186	Transcriptional regulator
H7H31_RS23225	COG1072	(Pantothenic acid kinase))
H7H31_RS23230	COG3397	chitin binding
H7H31_RS23245	COG1126	abc transporter atp-binding protein
H7H31_RS23250	COG0765	amino acid transport
H7H31_RS23255	COG0765	amino acid transport
H7H31_RS23270	COG0154	amidase activity
H7H31_RS23290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS23335	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS23360	COG0406	alpha-ribazole phosphatase activity
H7H31_RS23400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7H31_RS23405	COG4977	sequence-specific DNA binding
H7H31_RS23410	COG0589	response to stress
H7H31_RS23415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7H31_RS23430	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS23445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7H31_RS23450	COG1309	transcriptional regulator
H7H31_RS23475	COG1946	Acyl-CoA thioesterase
H7H31_RS23530	COG0583	DNA-binding transcription factor activity
H7H31_RS23535	COG0697	spore germination
H7H31_RS23545	COG1609	Transcriptional regulator
H7H31_RS23585	COG0673	inositol 2-dehydrogenase activity
H7H31_RS23595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7H31_RS23605	COG3718	enzyme involved in inositol metabolism
H7H31_RS23610	COG3962	Belongs to the TPP enzyme family
H7H31_RS23715	COG1289	transmembrane transporter activity
H7H31_RS23725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7H31_RS23730	COG1053	succinate dehydrogenase
H7H31_RS23740	COG0583	DNA-binding transcription factor activity
H7H31_RS23760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7H31_RS23760	COG1672	PFAM Archaeal ATPase
H7H31_RS23775	COG0723	plastoquinol--plastocyanin reductase activity
H7H31_RS23775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7H31_RS23805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7H31_RS23820	COG0640	Transcriptional regulator
H7H31_RS23835	COG1902	pentaerythritol trinitrate reductase activity
H7H31_RS23855	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H7H31_RS23860	COG1140	nitrate reductase beta subunit
H7H31_RS23895	COG4977	sequence-specific DNA binding
H7H31_RS23965	COG4221	oxidoreductase activity
H7H31_RS24035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7H31_RS24050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7H31_RS24090	COG0477	Major facilitator Superfamily
H7H31_RS24095	COG0629	single-stranded DNA binding
H7H31_RS24125	COG0577	efflux transmembrane transporter activity
H7H31_RS24125	COG1136	(ABC) transporter
H7H31_RS24150	COG2304	oxidoreductase activity
H7H31_RS24170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7H31_RS24200	COG1486	melibiose metabolic process
H7H31_RS24205	COG0395	ABC-type sugar transport system, permease component
H7H31_RS24210	COG1175	transmembrane transport
H7H31_RS24220	COG1940	carbohydrate kinase activity
H7H31_RS24220	COG1846	Transcriptional regulator
H7H31_RS24225	COG0668	transmembrane transport
H7H31_RS24255	COG4266	Belongs to the allantoicase family
H7H31_RS24270	COG1335	isochorismatase
H7H31_RS24310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7H31_RS24315	COG1113	amino acid transport
H7H31_RS24320	COG1113	amino acid transport
H7H31_RS24325	COG1268	BioY protein
H7H31_RS24330	COG1113	amino acid transport
H7H31_RS24350	COG0475	glutathione-regulated potassium exporter activity
H7H31_RS24355	COG1136	(ABC) transporter
H7H31_RS24390	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7H31_RS24395	COG0740	serine-type endopeptidase activity
H7H31_RS24400	COG0740	serine-type endopeptidase activity
H7H31_RS24405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7H31_RS24420	COG0525	valine-tRNA ligase activity
H7H31_RS24425	COG0285	dihydrofolate synthase activity
H7H31_RS24435	COG0105	UTP biosynthetic process
H7H31_RS24440	COG1077	Cell shape determining protein MreB Mrl
H7H31_RS24455	COG0768	penicillin binding
H7H31_RS24460	COG0772	Belongs to the SEDS family
H7H31_RS24500	COG1530	ribonuclease E activity
H7H31_RS24505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7H31_RS24510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7H31_RS24515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7H31_RS24525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7H31_RS24535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7H31_RS24550	COG0501	Belongs to the peptidase M48B family
H7H31_RS24565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7H31_RS24575	COG0799	negative regulation of ribosome biogenesis
H7H31_RS24580	COG0588	phosphoglycerate mutase activity
H7H31_RS24605	COG0577	efflux transmembrane transporter activity
H7H31_RS24605	COG1136	(ABC) transporter
H7H31_RS24610	COG0577	efflux transmembrane transporter activity
H7H31_RS24610	COG1136	(ABC) transporter
H7H31_RS24625	COG0745	RESPONSE REGULATOR receiver
H7H31_RS24630	COG2205	protein histidine kinase activity
H7H31_RS24640	COG0495	leucyl-tRNA aminoacylation
H7H31_RS24650	COG1307	EDD domain protein, DegV family
H7H31_RS24660	COG1555	photosystem II stabilization
H7H31_RS24695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7H31_RS24730	COG0268	Binds directly to 16S ribosomal RNA
H7H31_RS24735	COG0481	GTPase activity
H7H31_RS24740	COG1022	Amp-dependent synthetase and ligase
H7H31_RS24770	COG1420	regulation of RNA biosynthetic process
H7H31_RS24775	COG0484	heat shock protein binding
H7H31_RS24795	COG0537	adenosine 5'-monophosphoramidase activity
H7H31_RS24800	COG1234	tRNA 3'-trailer cleavage
H7H31_RS24815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7H31_RS24825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7H31_RS24860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7H31_RS24880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7H31_RS24890	COG2409	Drug exporters of the RND superfamily
H7H31_RS24900	COG2197	response regulator
H7H31_RS24920	COG1381	Involved in DNA repair and RecF pathway recombination
H7H31_RS24925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7H31_RS24930	COG2186	Transcriptional regulator
H7H31_RS24945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7H31_RS24950	COG1121	(ABC) transporter
H7H31_RS24955	COG3443	Belongs to the bacterial solute-binding protein 9 family
H7H31_RS24955	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7H31_RS24960	COG0423	glycine-tRNA ligase activity
H7H31_RS24965	COG0477	Major facilitator Superfamily
H7H31_RS24980	COG0574	Belongs to the PEP-utilizing enzyme family
H7H31_RS24980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7H31_RS24995	COG0531	amino acid
H7H31_RS25065	COG0702	epimerase
H7H31_RS25105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7H31_RS25115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7H31_RS25125	COG2153	protein acetylation
H7H31_RS25130	COG0358	DNA primase activity
H7H31_RS25135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7H31_RS25140	COG1070	Carbohydrate kinase
H7H31_RS25185	COG2801	Transposase and inactivated derivatives
H7H31_RS25185	COG3415	Transposase
H7H31_RS25195	COG0419	ATPase involved in DNA repair
H7H31_RS25225	COG0402	S-adenosylhomocysteine deaminase activity
H7H31_RS25230	COG2197	response regulator
H7H31_RS25270	COG0702	epimerase
H7H31_RS25285	COG3629	intracellular signal transduction
H7H31_RS25285	COG3903	Transcriptional regulator
H7H31_RS25295	COG2267	carboxylic ester hydrolase activity
H7H31_RS25320	COG2409	Drug exporters of the RND superfamily
H7H31_RS25345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7H31_RS25355	COG2030	dehydratase
H7H31_RS25365	COG0583	DNA-binding transcription factor activity
H7H31_RS25370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7H31_RS25375	COG0588	phosphoglycerate mutase activity
H7H31_RS25385	COG1309	transcriptional regulator
H7H31_RS25390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS25405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7H31_RS25415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7H31_RS25420	COG1045	serine acetyltransferase
H7H31_RS25435	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H7H31_RS25440	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H7H31_RS25450	COG0583	DNA-binding transcription factor activity
H7H31_RS25455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS25475	COG0076	glutamate decarboxylase activity
H7H31_RS25480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7H31_RS25490	COG2130	NADP-dependent
H7H31_RS25495	COG1764	response to oxidative stress
H7H31_RS25515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7H31_RS25520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS25525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7H31_RS25550	COG0789	Transcriptional regulator
H7H31_RS25555	COG0667	Aldo Keto reductase
H7H31_RS25570	COG2197	response regulator
H7H31_RS25575	COG4585	Histidine kinase
H7H31_RS25590	COG1309	transcriptional regulator
H7H31_RS25595	COG0477	Major facilitator Superfamily
H7H31_RS25605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7H31_RS25650	COG1358	cellular component organization or biogenesis
H7H31_RS25660	COG0586	Pfam SNARE associated Golgi protein
H7H31_RS25675	COG2197	response regulator
H7H31_RS25685	COG2188	Transcriptional regulator
H7H31_RS25710	COG0583	DNA-binding transcription factor activity
H7H31_RS25715	COG5640	endopeptidase activity
H7H31_RS25740	COG1196	nuclear chromosome segregation
H7H31_RS25740	COG0741	lytic transglycosylase activity
H7H31_RS25740	COG0739	heme binding
H7H31_RS25750	COG2259	Doxx family
H7H31_RS25840	COG2409	Drug exporters of the RND superfamily
H7H31_RS25865	COG0183	Belongs to the thiolase family
H7H31_RS25880	COG3845	ABC transporter
H7H31_RS25910	COG1309	transcriptional regulator
H7H31_RS25915	COG0438	transferase activity, transferring glycosyl groups
H7H31_RS25960	COG2197	response regulator
H7H31_RS25970	COG4585	Histidine kinase
H7H31_RS25980	COG1131	(ABC) transporter
H7H31_RS25990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7H31_RS25995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7H31_RS26010	COG0800	Aldolase
H7H31_RS26015	COG3022	response to hydroperoxide
H7H31_RS26045	COG0384	phenazine biosynthesis protein PhzF
H7H31_RS26050	COG3540	Alkaline phosphatase
H7H31_RS26060	COG2814	Major facilitator Superfamily
H7H31_RS26075	COG1834	amidinotransferase
H7H31_RS26085	COG1309	transcriptional regulator
H7H31_RS26100	COG1120	ATPase activity
H7H31_RS26105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS26110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7H31_RS26125	COG5398	heme oxygenase
H7H31_RS26180	COG1175	transmembrane transport
H7H31_RS26185	COG0395	ABC-type sugar transport system, permease component
H7H31_RS26200	COG1994	Peptidase M50
H7H31_RS26220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7H31_RS26225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7H31_RS26230	COG0477	Major facilitator Superfamily
H7H31_RS26235	COG1309	transcriptional regulator
H7H31_RS26245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7H31_RS26285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7H31_RS26285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7H31_RS26300	COG2132	Multicopper oxidase
H7H31_RS26315	COG3291	Pkd domain containing protein
H7H31_RS26320	COG0174	glutamine synthetase
H7H31_RS26340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7H31_RS26350	COG1609	Transcriptional regulator
H7H31_RS26355	COG0366	Alpha amylase catalytic
H7H31_RS26395	COG2197	response regulator
H7H31_RS26420	COG0745	RESPONSE REGULATOR receiver
H7H31_RS26450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS26465	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS26475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS26485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS26490	COG1120	ATPase activity
H7H31_RS26520	COG0438	transferase activity, transferring glycosyl groups
H7H31_RS26555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7H31_RS26560	COG0321	lipoyl(octanoyl) transferase activity
H7H31_RS26600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7H31_RS26610	COG4585	Histidine kinase
H7H31_RS26625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7H31_RS26630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7H31_RS26650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7H31_RS26650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7H31_RS26655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7H31_RS26670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7H31_RS26675	COG1132	(ABC) transporter
H7H31_RS26680	COG2226	methyltransferase
H7H31_RS26700	COG4585	Histidine kinase
H7H31_RS26705	COG2197	response regulator
H7H31_RS26710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7H31_RS26730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7H31_RS26735	COG1104	cysteine desulfurase activity
H7H31_RS26740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7H31_RS26745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7H31_RS26755	COG1376	ErfK ybiS ycfS ynhG family protein
H7H31_RS26765	COG1845	cytochrome c oxidase, subunit III
H7H31_RS26770	COG2010	Cytochrome c
H7H31_RS26775	COG0723	plastoquinol--plastocyanin reductase activity
H7H31_RS26780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7H31_RS26785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7H31_RS26790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7H31_RS26810	COG0705	Rhomboid family
H7H31_RS26860	COG0003	Pfam Anion-transporting ATPase
H7H31_RS26870	COG1940	carbohydrate kinase activity
H7H31_RS26900	COG2197	response regulator
H7H31_RS26905	COG0205	6-phosphofructokinase activity
H7H31_RS26915	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7H31_RS26920	COG0243	molybdopterin cofactor binding
H7H31_RS26925	COG2193	ferroxidase activity
H7H31_RS26930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7H31_RS26935	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7H31_RS26940	COG0515	serine threonine protein kinase
H7H31_RS26940	COG2815	serine threonine protein kinase
H7H31_RS26945	COG2022	thiamine diphosphate biosynthetic process
H7H31_RS26970	COG0352	thiamine-phosphate diphosphorylase activity
H7H31_RS26990	COG1309	transcriptional regulator
H7H31_RS27000	COG1129	ABC transporter
H7H31_RS27010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7H31_RS27030	COG0714	Associated with various cellular activities
H7H31_RS27040	COG0275	rRNA processing
H7H31_RS27050	COG0768	penicillin binding
H7H31_RS27055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7H31_RS27060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7H31_RS27065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7H31_RS27070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7H31_RS27080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7H31_RS27085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7H31_RS27090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7H31_RS27105	COG1799	cell septum assembly
H7H31_RS27115	COG3599	regulation of cell shape
H7H31_RS27120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7H31_RS27130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7H31_RS27180	COG0587	DNA-directed DNA polymerase activity
H7H31_RS27190	COG1432	Conserved Protein
H7H31_RS27210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7H31_RS27215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7H31_RS27225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7H31_RS27230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7H31_RS27235	COG0131	Imidazoleglycerol-phosphate dehydratase
H7H31_RS27245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7H31_RS27250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7H31_RS27255	COG0251	oxidation-reduction process
H7H31_RS27260	COG0107	imidazoleglycerol-phosphate synthase activity
H7H31_RS27300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7H31_RS27330	COG0134	indole-3-glycerol-phosphate synthase activity
H7H31_RS27335	COG0133	tryptophan synthase activity
H7H31_RS27340	COG0159	tryptophan synthase activity
H7H31_RS27360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7H31_RS27370	COG0069	glutamate synthase activity
H7H31_RS27370	COG0070	glutamate synthase
H7H31_RS27370	COG0067	glutamate synthase
H7H31_RS27395	COG1725	Transcriptional regulator
H7H31_RS27400	COG3842	ATPase activity
H7H31_RS27415	COG2267	carboxylic ester hydrolase activity
H7H31_RS27445	COG0028	Belongs to the TPP enzyme family
H7H31_RS27450	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS27460	COG0366	Alpha amylase catalytic
H7H31_RS27460	COG1470	cell adhesion involved in biofilm formation
H7H31_RS27470	COG0596	Alpha beta hydrolase
H7H31_RS27510	COG1605	Chorismate mutase
H7H31_RS27510	COG0287	Prephenate dehydrogenase
H7H31_RS27525	COG0702	epimerase
H7H31_RS27540	COG0737	Belongs to the 5'-nucleotidase family
H7H31_RS27565	COG2050	protein possibly involved in aromatic compounds catabolism
H7H31_RS27585	COG1643	Atp-dependent helicase
H7H31_RS27595	COG2226	methyltransferase
H7H31_RS27615	COG0237	dephospho-CoA kinase activity
H7H31_RS27650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7H31_RS27655	COG0584	glycerophosphoryl diester phosphodiesterase
H7H31_RS27670	COG0556	nucleotide-excision repair
H7H31_RS27700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7H31_RS27740	COG0322	excinuclease ABC activity
H7H31_RS27745	COG1660	Displays ATPase and GTPase activities
H7H31_RS27750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7H31_RS27755	COG1481	regulation of sporulation
H7H31_RS27760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7H31_RS27765	COG0126	phosphoglycerate kinase activity
H7H31_RS27770	COG0149	triose-phosphate isomerase activity
H7H31_RS27775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7H31_RS27785	COG0166	Belongs to the GPI family
H7H31_RS27790	COG0363	glucosamine-6-phosphate deaminase activity
H7H31_RS27805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7H31_RS27815	COG0109	protoheme IX farnesyltransferase activity
H7H31_RS27830	COG1612	heme a metabolic process
H7H31_RS27840	COG1131	(ABC) transporter
H7H31_RS27865	COG0396	ATPase activity
H7H31_RS27870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7H31_RS27875	COG0822	iron-sulfur transferase activity
H7H31_RS27890	COG2318	DinB family
H7H31_RS27895	COG2076	Multidrug Resistance protein
H7H31_RS27900	COG3226	Transcriptional regulator
H7H31_RS27905	COG2171	N-acyltransferase activity
H7H31_RS27925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS27950	COG1309	transcriptional regulator
H7H31_RS27960	COG1104	cysteine desulfurase activity
H7H31_RS27965	COG5285	phytanoyl-CoA dioxygenase
H7H31_RS27970	COG1917	Cupin 2, conserved barrel domain protein
H7H31_RS27975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7H31_RS28010	COG1797	cobyrinic acid a,c-diamide synthase activity
H7H31_RS28030	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H7H31_RS28045	COG0235	Class ii aldolase
H7H31_RS28075	COG0488	(ABC) transporter
H7H31_RS28095	COG1302	Protein conserved in bacteria
H7H31_RS28125	COG3387	PFAM Glycoside hydrolase 15-related
H7H31_RS28135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7H31_RS28160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7H31_RS28165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7H31_RS28185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7H31_RS28200	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS28205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7H31_RS28215	COG2186	Transcriptional regulator
H7H31_RS28220	COG2807	transmembrane transport
H7H31_RS28235	COG3830	Belongs to the UPF0237 family
H7H31_RS28235	COG0560	Phosphoserine phosphatase
H7H31_RS28240	COG1716	ATPase activity
H7H31_RS28240	COG0842	Transport permease protein
H7H31_RS28240	COG1131	(ABC) transporter
H7H31_RS28260	COG2197	response regulator
H7H31_RS28275	COG1119	ATPase activity
H7H31_RS28295	COG1881	PFAM PEBP family protein
H7H31_RS28310	COG2094	Belongs to the DNA glycosylase MPG family
H7H31_RS28350	COG0154	amidase activity
H7H31_RS28355	COG1309	transcriptional regulator
H7H31_RS28365	COG0647	UMP catabolic process
H7H31_RS28380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS28385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS28405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7H31_RS28410	COG0497	DNA recombination
H7H31_RS28425	COG3387	PFAM Glycoside hydrolase 15-related
H7H31_RS28430	COG0504	CTP synthase activity
H7H31_RS28435	COG0494	nUDIX hydrolase
H7H31_RS28445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7H31_RS28455	COG1959	2 iron, 2 sulfur cluster binding
H7H31_RS28460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7H31_RS28470	COG0686	Belongs to the AlaDH PNT family
H7H31_RS28490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7H31_RS28495	COG1187	pseudouridine synthase activity
H7H31_RS28515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7H31_RS28520	COG0204	Acyl-transferase
H7H31_RS28525	COG1160	GTP binding
H7H31_RS28540	COG0438	transferase activity, transferring glycosyl groups
H7H31_RS28560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7H31_RS28570	COG0671	phosphoesterase, PA-phosphatase related
H7H31_RS28575	COG0477	Major facilitator Superfamily
H7H31_RS28580	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS28585	COG1799	cell septum assembly
H7H31_RS28600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS28605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS28620	COG0330	HflC and HflK could
H7H31_RS28635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7H31_RS28680	COG2226	methyltransferase
H7H31_RS28685	COG2409	Drug exporters of the RND superfamily
H7H31_RS28690	COG2362	D-Aminopeptidase
H7H31_RS28695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7H31_RS28715	COG1120	ATPase activity
H7H31_RS28720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS28725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS28730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7H31_RS28735	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS28740	COG1169	isochorismate synthase
H7H31_RS28745	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7H31_RS28750	COG3433	isochorismatase activity
H7H31_RS28750	COG1535	isochorismatase
H7H31_RS28755	COG3433	isochorismatase activity
H7H31_RS28755	COG1535	isochorismatase
H7H31_RS28760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS28760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS28785	COG1595	DNA-templated transcription, initiation
H7H31_RS28795	COG0789	Transcriptional regulator
H7H31_RS28825	COG2208	phosphoserine phosphatase activity
H7H31_RS28825	COG2770	Histidine kinase
H7H31_RS28830	COG0596	Alpha beta hydrolase
H7H31_RS28835	COG2267	carboxylic ester hydrolase activity
H7H31_RS28855	COG2814	Major facilitator Superfamily
H7H31_RS28880	COG3629	intracellular signal transduction
H7H31_RS28880	COG3903	Transcriptional regulator
H7H31_RS28925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS28940	COG2382	esterase
H7H31_RS28950	COG0789	Transcriptional regulator
H7H31_RS28955	COG0300	oxidoreductase activity
H7H31_RS28975	COG1597	lipid kinase activity
H7H31_RS28980	COG0517	IMP dehydrogenase activity
H7H31_RS28995	COG0693	protein deglycase activity
H7H31_RS29050	COG0596	Alpha beta hydrolase
H7H31_RS29065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7H31_RS29080	COG0531	amino acid
H7H31_RS29095	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS29100	COG1309	transcriptional regulator
H7H31_RS29120	COG5492	domain, Protein
H7H31_RS29150	COG4585	Histidine kinase
H7H31_RS29155	COG2409	Drug exporters of the RND superfamily
H7H31_RS29165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7H31_RS29180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7H31_RS29185	COG1191	sigma factor activity
H7H31_RS29210	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7H31_RS29215	COG1302	Protein conserved in bacteria
H7H31_RS29220	COG1595	DNA-templated transcription, initiation
H7H31_RS29250	COG0583	DNA-binding transcription factor activity
H7H31_RS29255	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS29260	COG0656	L-ascorbic acid biosynthetic process
H7H31_RS29290	COG0583	DNA-binding transcription factor activity
H7H31_RS29315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7H31_RS29350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7H31_RS29365	COG0187	DNA topoisomerase II activity
H7H31_RS29380	COG1404	Belongs to the peptidase S8 family
H7H31_RS29390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7H31_RS29395	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7H31_RS29405	COG1215	transferase activity, transferring glycosyl groups
H7H31_RS29415	COG4310	Domain of unknown function (DUF2172)
H7H31_RS29430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7H31_RS29465	COG0367	asparagine synthase
H7H31_RS29485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7H31_RS29490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7H31_RS29495	COG3540	Alkaline phosphatase
H7H31_RS29530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS29545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7H31_RS29605	COG1073	alpha beta
H7H31_RS29650	COG1522	sequence-specific DNA binding
H7H31_RS29655	COG0697	spore germination
H7H31_RS29680	COG1595	DNA-templated transcription, initiation
H7H31_RS29685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS29690	COG0431	NADPH-dependent FMN reductase
H7H31_RS29700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7H31_RS29705	COG1126	abc transporter atp-binding protein
H7H31_RS29710	COG0765	amino acid transport
H7H31_RS29720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS29725	COG0235	Class ii aldolase
H7H31_RS29725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7H31_RS29730	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7H31_RS29730	COG0235	Class ii aldolase
H7H31_RS29735	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7H31_RS29740	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H7H31_RS29755	COG0640	Transcriptional regulator
H7H31_RS29760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7H31_RS29790	COG4585	Histidine kinase
H7H31_RS29810	COG4172	Belongs to the ABC transporter superfamily
H7H31_RS29815	COG4171	peptide transport system, permease
H7H31_RS29835	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7H31_RS29865	COG1515	deoxyribonuclease V activity
H7H31_RS29880	COG3268	Saccharopine dehydrogenase
H7H31_RS29885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7H31_RS29910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7H31_RS29920	COG0183	Belongs to the thiolase family
H7H31_RS29925	COG1024	Enoyl-CoA hydratase
H7H31_RS29925	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS29945	COG1113	amino acid transport
H7H31_RS29960	COG2936	dipeptidyl-peptidase activity
H7H31_RS29965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7H31_RS29990	COG0488	(ABC) transporter
H7H31_RS30000	COG0488	(ABC) transporter
H7H31_RS30005	COG0596	Alpha beta hydrolase
H7H31_RS30010	COG2183	response to ionizing radiation
H7H31_RS30020	COG1024	Enoyl-CoA hydratase
H7H31_RS30030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H7H31_RS30075	COG1134	teichoic acid transport
H7H31_RS30085	COG1562	ergosterol biosynthetic process
H7H31_RS30095	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7H31_RS30105	COG1657	PFAM Prenyltransferase squalene oxidase
H7H31_RS30130	COG2755	lipolytic protein G-D-S-L family
H7H31_RS30160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7H31_RS30205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7H31_RS30210	COG2364	Membrane
H7H31_RS30225	COG3958	Transketolase
H7H31_RS30230	COG3959	Transketolase, thiamine diphosphate binding domain
H7H31_RS30240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7H31_RS30245	COG3469	chitinase activity
H7H31_RS30260	COG1902	pentaerythritol trinitrate reductase activity
H7H31_RS30275	COG2197	response regulator
H7H31_RS30290	COG0464	growth
H7H31_RS30410	COG2746	aminoglycoside 3-N-acetyltransferase activity
H7H31_RS30455	COG0659	secondary active sulfate transmembrane transporter activity
H7H31_RS30460	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7H31_RS30465	COG2936	dipeptidyl-peptidase activity
H7H31_RS30475	COG1309	transcriptional regulator
H7H31_RS30485	COG0515	serine threonine protein kinase
H7H31_RS30505	COG0477	Major facilitator Superfamily
H7H31_RS30515	COG0745	RESPONSE REGULATOR receiver
H7H31_RS30520	COG2205	protein histidine kinase activity
H7H31_RS30555	COG1129	ABC transporter
H7H31_RS30560	COG1879	ABC-type sugar transport system periplasmic component
H7H31_RS30565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7H31_RS30575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7H31_RS30605	COG0463	Glycosyl transferase, family 2
H7H31_RS30635	COG1131	(ABC) transporter
H7H31_RS30645	COG0745	RESPONSE REGULATOR receiver
H7H31_RS30650	COG2205	protein histidine kinase activity
H7H31_RS30655	COG1309	transcriptional regulator
H7H31_RS30660	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS30675	COG0789	Transcriptional regulator
H7H31_RS30690	COG0312	modulator of DNA gyrase
H7H31_RS30695	COG0312	modulator of DNA gyrase
H7H31_RS30705	COG2022	thiamine diphosphate biosynthetic process
H7H31_RS30705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7H31_RS30745	COG0431	NADPH-dependent FMN reductase
H7H31_RS30750	COG1725	Transcriptional regulator
H7H31_RS30755	COG1131	(ABC) transporter
H7H31_RS30765	COG1404	Belongs to the peptidase S8 family
H7H31_RS30795	COG0328	RNA-DNA hybrid ribonuclease activity
H7H31_RS30810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7H31_RS30820	COG2070	2-Nitropropane dioxygenase
H7H31_RS30820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7H31_RS30825	COG1024	Enoyl-CoA hydratase
H7H31_RS30835	COG0300	oxidoreductase activity
H7H31_RS30835	COG3321	synthase
H7H31_RS30835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS30835	COG4221	oxidoreductase activity
H7H31_RS30840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS30840	COG0300	oxidoreductase activity
H7H31_RS30840	COG3321	synthase
H7H31_RS30840	COG4221	oxidoreductase activity
H7H31_RS30845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS30845	COG4221	oxidoreductase activity
H7H31_RS30845	COG3321	synthase
H7H31_RS30845	COG0300	oxidoreductase activity
H7H31_RS30850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS30850	COG3321	synthase
H7H31_RS30850	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS30850	COG4221	oxidoreductase activity
H7H31_RS30855	COG4221	oxidoreductase activity
H7H31_RS30855	COG3321	synthase
H7H31_RS30855	COG0300	oxidoreductase activity
H7H31_RS30855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS30860	COG3321	synthase
H7H31_RS30860	COG0604	alcohol dehydrogenase
H7H31_RS30865	COG3425	synthase
H7H31_RS30870	COG1024	Enoyl-CoA hydratase
H7H31_RS30875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS30880	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS30890	COG0793	Belongs to the peptidase S41A family
H7H31_RS30890	COG3409	Peptidoglycan-binding domain 1 protein
H7H31_RS30945	COG4044	May play a role in the intracellular transport of hydrophobic ligands
H7H31_RS30960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7H31_RS30965	COG1595	DNA-templated transcription, initiation
H7H31_RS30985	COG1335	isochorismatase
H7H31_RS30990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7H31_RS30995	COG1454	alcohol dehydrogenase
H7H31_RS31000	COG1090	epimerase
H7H31_RS31005	COG2226	methyltransferase
H7H31_RS31015	COG2375	cellular response to nickel ion
H7H31_RS31025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS31030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7H31_RS31035	COG1120	ATPase activity
H7H31_RS31050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7H31_RS31060	COG4251	negative regulation of phosphorylation
H7H31_RS31065	COG0784	Response regulator, receiver
H7H31_RS31075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7H31_RS31080	COG0367	asparagine synthase
H7H31_RS31140	COG2318	DinB family
H7H31_RS31200	COG1404	Belongs to the peptidase S8 family
H7H31_RS31235	COG2197	response regulator
H7H31_RS31240	COG4585	Histidine kinase
H7H31_RS31270	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS31340	COG1309	transcriptional regulator
H7H31_RS31350	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS31380	COG0463	Glycosyl transferase, family 2
H7H31_RS31400	COG2186	Transcriptional regulator
H7H31_RS31420	COG0154	amidase activity
H7H31_RS31425	COG1556	Lactate utilization protein
H7H31_RS31430	COG1139	Iron-sulfur cluster binding protein
H7H31_RS31435	COG0247	lactate metabolic process
H7H31_RS31445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS31460	COG1116	anion transmembrane transporter activity
H7H31_RS31465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7H31_RS31485	COG1295	ribonuclease BN
H7H31_RS31485	COG1959	2 iron, 2 sulfur cluster binding
H7H31_RS31490	COG0432	Pfam Uncharacterised protein family UPF0047
H7H31_RS31500	COG1672	PFAM Archaeal ATPase
H7H31_RS31500	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7H31_RS31535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7H31_RS31545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7H31_RS31550	COG1881	PFAM PEBP family protein
H7H31_RS31565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7H31_RS31595	COG0386	Belongs to the glutathione peroxidase family
H7H31_RS31610	COG3973	AAA domain
H7H31_RS31620	COG3795	YCII-related domain
H7H31_RS31625	COG4941	Belongs to the sigma-70 factor family
H7H31_RS31630	COG0242	peptide deformylase activity
H7H31_RS31645	COG0590	tRNA wobble adenosine to inosine editing
H7H31_RS31665	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H7H31_RS31680	COG0546	phosphoglycolate phosphatase activity
H7H31_RS31685	COG1522	sequence-specific DNA binding
H7H31_RS31705	COG3795	YCII-related domain
H7H31_RS31710	COG2706	6-phosphogluconolactonase activity
H7H31_RS31730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7H31_RS31735	COG1902	pentaerythritol trinitrate reductase activity
H7H31_RS31750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7H31_RS31755	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H7H31_RS31760	COG1691	(AIR) carboxylase
H7H31_RS31765	COG1606	tRNA processing
H7H31_RS31770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS31775	COG0640	Transcriptional regulator
H7H31_RS31800	COG1309	transcriptional regulator
H7H31_RS31830	COG2197	response regulator
H7H31_RS31835	COG4585	Histidine kinase
H7H31_RS31860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7H31_RS31865	COG0318	PFAM AMP-dependent synthetase and ligase
H7H31_RS31875	COG2197	response regulator
H7H31_RS31880	COG4585	Histidine kinase
H7H31_RS31890	COG4249	Peptidase C14 caspase catalytic subunit p20
H7H31_RS31890	COG2319	Wd-40 repeat
H7H31_RS31955	COG2814	Major facilitator Superfamily
H7H31_RS31965	COG2340	Cysteine-rich secretory protein family
H7H31_RS31970	COG1472	Belongs to the glycosyl hydrolase 3 family
H7H31_RS31980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7H31_RS31990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7H31_RS32000	COG1278	Cold shock
H7H31_RS32005	COG0513	Belongs to the DEAD box helicase family
H7H31_RS32010	COG1959	2 iron, 2 sulfur cluster binding
H7H31_RS32015	COG2207	Transcriptional regulator
H7H31_RS32020	COG2223	nitrite transmembrane transporter activity
H7H31_RS32025	COG5640	endopeptidase activity
H7H31_RS32040	COG2755	lipolytic protein G-D-S-L family
H7H31_RS32065	COG0596	Alpha beta hydrolase
H7H31_RS32075	COG1309	transcriptional regulator
H7H31_RS32085	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7H31_RS32090	COG3246	L-lysine catabolic process to acetate
H7H31_RS32100	COG0673	inositol 2-dehydrogenase activity
H7H31_RS32130	COG1486	melibiose metabolic process
H7H31_RS32150	COG1175	transmembrane transport
H7H31_RS32160	COG1653	transport
H7H31_RS32165	COG1175	transmembrane transport
H7H31_RS32170	COG0395	ABC-type sugar transport system, permease component
H7H31_RS32175	COG1278	Cold shock
H7H31_RS32185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS32210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7H31_RS32210	COG1028	Short-chain dehydrogenase reductase Sdr
H7H31_RS32210	COG3321	synthase
H7H31_RS32210	COG4221	oxidoreductase activity
H7H31_RS32255	COG2207	Transcriptional regulator
H7H31_RS32275	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H7H31_RS32280	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS32285	COG1982	Orn Lys Arg decarboxylase major
H7H31_RS32375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7H31_RS32430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7H31_RS32440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7H31_RS32460	COG0640	Transcriptional regulator
H7H31_RS32480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7H31_RS32515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7H31_RS32520	COG4948	Mandelate Racemase Muconate Lactonizing
H7H31_RS32535	COG0747	negative chemotaxis
H7H31_RS32550	COG4172	Belongs to the ABC transporter superfamily
H7H31_RS32555	COG1132	(ABC) transporter
H7H31_RS32565	COG0492	ferredoxin-NADP+ reductase activity
H7H31_RS32580	COG0531	amino acid
H7H31_RS32590	COG2124	cytochrome p450
H7H31_RS32590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7H31_RS32610	COG3360	Dodecin
H7H31_RS32625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7H31_RS32630	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7H31_RS32640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7H31_RS32665	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS32730	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS32740	COG1960	acyl-CoA dehydrogenase activity
H7H31_RS32750	COG0601	transmembrane transport
H7H31_RS32755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7H31_RS32770	COG1124	(ABC) transporter
H7H31_RS32775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7H31_RS32780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7H31_RS32810	COG2353	YceI-like domain
H7H31_RS32820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7H31_RS32850	COG2018	Roadblock/LC7 domain
H7H31_RS32860	COG1946	Acyl-CoA thioesterase
H7H31_RS32890	COG1132	(ABC) transporter
H7H31_RS32910	COG1349	DNA-binding transcription factor activity
H7H31_RS32925	COG0395	ABC-type sugar transport system, permease component
H7H31_RS32930	COG1063	alcohol dehydrogenase
H7H31_RS32935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7H31_RS32940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7H31_RS32940	COG1796	DNA polymerase
H7H31_RS32950	COG1793	dna ligase
H7H31_RS32995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7H31_RS33000	COG1196	nuclear chromosome segregation
H7H31_RS33000	COG0739	heme binding
H7H31_RS33000	COG0741	lytic transglycosylase activity
H7H31_RS33030	COG0142	geranyltranstransferase activity
H7H31_RS33040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7H31_RS33055	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H7H31_RS33060	COG2409	Drug exporters of the RND superfamily
H7H31_RS33130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7H31_RS33155	COG0596	Alpha beta hydrolase
H7H31_RS33175	COG0583	DNA-binding transcription factor activity
H7H31_RS33190	COG1012	belongs to the aldehyde dehydrogenase family
H7H31_RS33195	COG0367	asparagine synthase
H7H31_RS33240	COG2706	6-phosphogluconolactonase activity
H7H31_RS33250	COG3979	chitinase
H7H31_RS33260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7H31_RS33260	COG0515	serine threonine protein kinase
H7H31_RS33330	COG1309	transcriptional regulator
H7H31_RS33385	COG2801	Transposase and inactivated derivatives
H7H31_RS33385	COG3415	Transposase