locus-tag	class	description
LGI35_RS00100	COG2226	methyltransferase
LGI35_RS00105	COG0583	DNA-binding transcription factor activity
LGI35_RS00155	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS00175	COG0583	DNA-binding transcription factor activity
LGI35_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS00190	COG0531	amino acid
LGI35_RS00225	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS00230	COG3268	Saccharopine dehydrogenase
LGI35_RS00235	COG0113	porphobilinogen synthase activity
LGI35_RS00245	COG0477	Major facilitator Superfamily
LGI35_RS00255	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS00260	COG1309	transcriptional regulator
LGI35_RS00280	COG2409	Drug exporters of the RND superfamily
LGI35_RS00295	COG0446	pyridine nucleotide-disulphide oxidoreductase
LGI35_RS00295	COG1902	pentaerythritol trinitrate reductase activity
LGI35_RS00315	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS00330	COG1902	pentaerythritol trinitrate reductase activity
LGI35_RS00330	COG0446	pyridine nucleotide-disulphide oxidoreductase
LGI35_RS00335	COG1309	transcriptional regulator
LGI35_RS00355	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS00365	COG1309	transcriptional regulator
LGI35_RS00375	COG1846	Transcriptional regulator
LGI35_RS00415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS00420	COG0601	transmembrane transport
LGI35_RS00425	COG0747	negative chemotaxis
LGI35_RS00430	COG1082	Xylose isomerase domain protein TIM barrel
LGI35_RS00435	COG0673	inositol 2-dehydrogenase activity
LGI35_RS00440	COG1940	carbohydrate kinase activity
LGI35_RS00480	COG1113	amino acid transport
LGI35_RS00490	COG1027	Aspartate ammonia-lyase
LGI35_RS00495	COG2066	Belongs to the glutaminase family
LGI35_RS00560	COG0667	Aldo Keto reductase
LGI35_RS00635	COG2936	dipeptidyl-peptidase activity
LGI35_RS00725	COG0745	RESPONSE REGULATOR receiver
LGI35_RS00730	COG2205	protein histidine kinase activity
LGI35_RS00845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LGI35_RS00885	COG0542	response to heat
LGI35_RS00900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LGI35_RS00905	COG0443	Heat shock 70 kDa protein
LGI35_RS00915	COG3835	regulator
LGI35_RS00920	COG0583	DNA-binding transcription factor activity
LGI35_RS01115	COG3547	Transposase (IS116 IS110 IS902 family)
LGI35_RS01145	COG0675	Transposase, IS605 OrfB family
LGI35_RS01155	COG1073	alpha beta
LGI35_RS01165	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LGI35_RS01180	COG2271	Major facilitator Superfamily
LGI35_RS01185	COG0129	dihydroxy-acid dehydratase activity
LGI35_RS01190	COG3573	Dehydrogenase
LGI35_RS01255	COG1309	transcriptional regulator
LGI35_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS01335	COG2271	Major facilitator Superfamily
LGI35_RS01340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LGI35_RS01340	COG2508	Transcriptional regulator
LGI35_RS01435	COG0577	efflux transmembrane transporter activity
LGI35_RS01435	COG1136	(ABC) transporter
LGI35_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS01550	COG0604	alcohol dehydrogenase
LGI35_RS01560	COG0604	alcohol dehydrogenase
LGI35_RS01590	COG1404	Belongs to the peptidase S8 family
LGI35_RS01665	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LGI35_RS01700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LGI35_RS01705	COG1309	transcriptional regulator
LGI35_RS01710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS01725	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LGI35_RS01795	COG0583	DNA-binding transcription factor activity
LGI35_RS01800	COG4221	oxidoreductase activity
LGI35_RS01815	COG2132	Multicopper oxidase
LGI35_RS01835	COG1191	sigma factor activity
LGI35_RS02010	COG0745	RESPONSE REGULATOR receiver
LGI35_RS02015	COG2205	protein histidine kinase activity
LGI35_RS02030	COG0642	Histidine kinase
LGI35_RS02040	COG1136	(ABC) transporter
LGI35_RS02045	COG1136	(ABC) transporter
LGI35_RS02070	COG0672	)-iron permease
LGI35_RS02090	COG4172	Belongs to the ABC transporter superfamily
LGI35_RS02095	COG4171	peptide transport system, permease
LGI35_RS02105	COG4166	transmembrane transport
LGI35_RS02120	COG0019	diaminopimelate decarboxylase activity
LGI35_RS02125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LGI35_RS02240	COG1408	metallophosphoesterase
LGI35_RS02265	COG0596	Alpha beta hydrolase
LGI35_RS02275	COG2801	Transposase and inactivated derivatives
LGI35_RS02325	COG1595	DNA-templated transcription, initiation
LGI35_RS02340	COG0515	serine threonine protein kinase
LGI35_RS02340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LGI35_RS02365	COG0604	alcohol dehydrogenase
LGI35_RS02405	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LGI35_RS02405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LGI35_RS02405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LGI35_RS02415	COG1349	DNA-binding transcription factor activity
LGI35_RS02645	COG2208	phosphoserine phosphatase activity
LGI35_RS02645	COG2770	Histidine kinase
LGI35_RS02665	COG5640	endopeptidase activity
LGI35_RS02685	COG0675	Transposase, IS605 OrfB family
LGI35_RS02735	COG0477	Major facilitator Superfamily
LGI35_RS02755	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS02760	COG0675	Transposase, IS605 OrfB family
LGI35_RS02790	COG1309	transcriptional regulator
LGI35_RS02800	COG0583	DNA-binding transcription factor activity
LGI35_RS02805	COG0702	epimerase
LGI35_RS02825	COG4733	cellulase activity
LGI35_RS02825	COG4447	cellulose binding
LGI35_RS02830	COG5297	Belongs to the glycosyl hydrolase family 6
LGI35_RS02845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LGI35_RS02855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LGI35_RS02895	COG1175	transmembrane transport
LGI35_RS02900	COG0395	ABC-type sugar transport system, permease component
LGI35_RS02920	COG1609	Transcriptional regulator
LGI35_RS02930	COG3848	Pyruvate phosphate dikinase
LGI35_RS02930	COG0574	Belongs to the PEP-utilizing enzyme family
LGI35_RS02955	COG4948	Mandelate Racemase Muconate Lactonizing
LGI35_RS02980	COG4977	sequence-specific DNA binding
LGI35_RS03000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LGI35_RS03030	COG3387	PFAM Glycoside hydrolase 15-related
LGI35_RS03065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LGI35_RS03080	COG1215	transferase activity, transferring glycosyl groups
LGI35_RS03090	COG4310	Domain of unknown function (DUF2172)
LGI35_RS03105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LGI35_RS03160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LGI35_RS03185	COG0789	Transcriptional regulator
LGI35_RS03195	COG2080	2 iron, 2 sulfur cluster binding
LGI35_RS03200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LGI35_RS03205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LGI35_RS03210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LGI35_RS03240	COG1881	PFAM PEBP family protein
LGI35_RS03290	COG0395	ABC-type sugar transport system, permease component
LGI35_RS03300	COG1609	Transcriptional regulator
LGI35_RS03335	COG1522	sequence-specific DNA binding
LGI35_RS03350	COG0473	3-isopropylmalate dehydrogenase activity
LGI35_RS03355	COG0747	negative chemotaxis
LGI35_RS03365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS03375	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS03380	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS03415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LGI35_RS03430	COG3507	Belongs to the glycosyl hydrolase 43 family
LGI35_RS03435	COG1501	Belongs to the glycosyl hydrolase 31 family
LGI35_RS03450	COG4209	transmembrane transport
LGI35_RS03455	COG0395	ABC-type sugar transport system, permease component
LGI35_RS03480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS03485	COG0589	response to stress
LGI35_RS03505	COG2175	clavaminate synthase activity
LGI35_RS03515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LGI35_RS03520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LGI35_RS03530	COG0577	efflux transmembrane transporter activity
LGI35_RS03530	COG1136	(ABC) transporter
LGI35_RS03535	COG4585	Histidine kinase
LGI35_RS03540	COG2197	response regulator
LGI35_RS03545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LGI35_RS03550	COG3135	benzoate transporter
LGI35_RS03600	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS03625	COG2318	DinB family
LGI35_RS03655	COG0156	8-amino-7-oxononanoate synthase activity
LGI35_RS03660	COG0531	amino acid
LGI35_RS03675	COG0587	DNA-directed DNA polymerase activity
LGI35_RS03715	COG1063	alcohol dehydrogenase
LGI35_RS03720	COG0667	Aldo Keto reductase
LGI35_RS03735	COG1073	alpha beta
LGI35_RS03760	COG1764	response to oxidative stress
LGI35_RS03810	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LGI35_RS03850	COG0516	GMP reductase activity
LGI35_RS03850	COG0517	IMP dehydrogenase activity
LGI35_RS03855	COG0517	IMP dehydrogenase activity
LGI35_RS03855	COG0516	GMP reductase activity
LGI35_RS03925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LGI35_RS03935	COG1063	alcohol dehydrogenase
LGI35_RS03945	COG3293	Transposase
LGI35_RS03955	COG2205	protein histidine kinase activity
LGI35_RS03960	COG0745	RESPONSE REGULATOR receiver
LGI35_RS03965	COG1017	nitric oxide dioxygenase activity
LGI35_RS03965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LGI35_RS03970	COG1053	succinate dehydrogenase
LGI35_RS03970	COG3976	FMN-binding domain protein
LGI35_RS03970	COG0431	NADPH-dependent FMN reductase
LGI35_RS03985	COG3655	Transcriptional regulator
LGI35_RS04010	COG0154	amidase activity
LGI35_RS04020	COG1366	Belongs to the anti-sigma-factor antagonist family
LGI35_RS04020	COG2172	sigma factor antagonist activity
LGI35_RS04020	COG2208	phosphoserine phosphatase activity
LGI35_RS04070	COG2271	Major facilitator Superfamily
LGI35_RS04085	COG1309	transcriptional regulator
LGI35_RS04095	COG3665	Urea carboxylase-associated protein
LGI35_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS04120	COG1024	Enoyl-CoA hydratase
LGI35_RS04155	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LGI35_RS04175	COG0574	Belongs to the PEP-utilizing enzyme family
LGI35_RS04175	COG3848	Pyruvate phosphate dikinase
LGI35_RS04195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS04200	COG0601	transmembrane transport
LGI35_RS04205	COG4166	transmembrane transport
LGI35_RS04230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LGI35_RS04245	COG2188	Transcriptional regulator
LGI35_RS04265	COG0477	Major facilitator Superfamily
LGI35_RS04320	COG0456	acetyltransferase
LGI35_RS04320	COG1846	Transcriptional regulator
LGI35_RS04330	COG1917	Cupin 2, conserved barrel domain protein
LGI35_RS04330	COG4977	sequence-specific DNA binding
LGI35_RS04350	COG1175	transmembrane transport
LGI35_RS04355	COG0395	ABC-type sugar transport system, permease component
LGI35_RS04370	COG3119	arylsulfatase activity
LGI35_RS04380	COG0366	Alpha amylase catalytic
LGI35_RS04390	COG1472	Belongs to the glycosyl hydrolase 3 family
LGI35_RS04395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LGI35_RS04405	COG1472	Belongs to the glycosyl hydrolase 3 family
LGI35_RS04420	COG1737	Transcriptional regulator
LGI35_RS04425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LGI35_RS04435	COG0601	transmembrane transport
LGI35_RS04440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS04445	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS04450	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS04455	COG3103	Sh3 type 3 domain protein
LGI35_RS04455	COG0791	NLP P60 protein
LGI35_RS04455	COG1388	LysM domain
LGI35_RS04495	COG1175	transmembrane transport
LGI35_RS04500	COG0395	ABC-type sugar transport system, permease component
LGI35_RS04505	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
LGI35_RS04510	COG0673	inositol 2-dehydrogenase activity
LGI35_RS04515	COG0366	Alpha amylase catalytic
LGI35_RS04520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LGI35_RS04550	COG4585	Histidine kinase
LGI35_RS04560	COG1454	alcohol dehydrogenase
LGI35_RS04565	COG3485	protocatechuate 3,4-dioxygenase
LGI35_RS04585	COG0154	amidase activity
LGI35_RS04595	COG2132	Multicopper oxidase
LGI35_RS04650	COG0640	Transcriptional regulator
LGI35_RS04665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LGI35_RS04680	COG2508	Transcriptional regulator
LGI35_RS04680	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LGI35_RS04690	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS04695	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS04725	COG2271	Major facilitator Superfamily
LGI35_RS04735	COG4948	Mandelate Racemase Muconate Lactonizing
LGI35_RS04750	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LGI35_RS04755	COG1522	sequence-specific DNA binding
LGI35_RS04775	COG0789	Transcriptional regulator
LGI35_RS04800	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LGI35_RS04805	COG2188	Transcriptional regulator
LGI35_RS04820	COG2986	histidine ammonia-lyase
LGI35_RS04840	COG0028	Belongs to the TPP enzyme family
LGI35_RS04845	COG1522	sequence-specific DNA binding
LGI35_RS04865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LGI35_RS04900	COG5006	permease, DMT superfamily
LGI35_RS04905	COG0583	DNA-binding transcription factor activity
LGI35_RS04910	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS04930	COG2175	clavaminate synthase activity
LGI35_RS04945	COG0475	glutathione-regulated potassium exporter activity
LGI35_RS04945	COG0569	domain protein
LGI35_RS04950	COG4941	Belongs to the sigma-70 factor family
LGI35_RS04955	COG3795	YCII-related domain
LGI35_RS04965	COG0730	response to heat
LGI35_RS04970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LGI35_RS04970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LGI35_RS04975	COG1937	Protein conserved in bacteria
LGI35_RS05000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LGI35_RS05005	COG2318	DinB family
LGI35_RS05020	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS05030	COG0747	negative chemotaxis
LGI35_RS05040	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS05045	COG0601	transmembrane transport
LGI35_RS05050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS05060	COG2188	Transcriptional regulator
LGI35_RS05070	COG0515	serine threonine protein kinase
LGI35_RS05100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS05100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS05105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LGI35_RS05115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS05120	COG4770	biotin carboxylase activity
LGI35_RS05135	COG2814	Major facilitator Superfamily
LGI35_RS05145	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS05180	COG0583	DNA-binding transcription factor activity
LGI35_RS05190	COG2070	2-Nitropropane dioxygenase
LGI35_RS05240	COG1335	isochorismatase
LGI35_RS05250	COG4977	sequence-specific DNA binding
LGI35_RS05260	COG0477	Major facilitator Superfamily
LGI35_RS05280	COG4941	Belongs to the sigma-70 factor family
LGI35_RS05285	COG3795	YCII-related domain
LGI35_RS05305	COG0640	Transcriptional regulator
LGI35_RS05310	COG0346	lactoylglutathione lyase activity
LGI35_RS05375	COG4106	trans-aconitate 2-methyltransferase activity
LGI35_RS05380	COG1088	dTDP-glucose 4,6-dehydratase activity
LGI35_RS05385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LGI35_RS05390	COG0745	RESPONSE REGULATOR receiver
LGI35_RS05395	COG2205	protein histidine kinase activity
LGI35_RS05405	COG1280	lysine exporter protein (LysE YggA)
LGI35_RS05415	COG0477	Major facilitator Superfamily
LGI35_RS05420	COG1228	amidohydrolase
LGI35_RS05460	COG4585	Histidine kinase
LGI35_RS05465	COG2197	response regulator
LGI35_RS05485	COG0243	molybdopterin cofactor binding
LGI35_RS05560	COG0009	L-threonylcarbamoyladenylate synthase
LGI35_RS05610	COG2197	response regulator
LGI35_RS05620	COG0076	glutamate decarboxylase activity
LGI35_RS05630	COG2208	phosphoserine phosphatase activity
LGI35_RS05630	COG2770	Histidine kinase
LGI35_RS05650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LGI35_RS05655	COG2124	cytochrome p450
LGI35_RS05670	COG3903	Transcriptional regulator
LGI35_RS05670	COG3629	intracellular signal transduction
LGI35_RS05685	COG2070	2-Nitropropane dioxygenase
LGI35_RS05700	COG2304	oxidoreductase activity
LGI35_RS05835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS05840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LGI35_RS05845	COG1556	Lactate utilization protein
LGI35_RS05850	COG1139	Iron-sulfur cluster binding protein
LGI35_RS05860	COG2186	Transcriptional regulator
LGI35_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS05870	COG0179	Fumarylacetoacetate (FAA) hydrolase
LGI35_RS05875	COG0477	Major facilitator Superfamily
LGI35_RS05880	COG4948	Mandelate Racemase Muconate Lactonizing
LGI35_RS05900	COG2814	Major facilitator Superfamily
LGI35_RS05985	COG1302	Protein conserved in bacteria
LGI35_RS05990	COG1595	DNA-templated transcription, initiation
LGI35_RS06060	COG2890	protein-(glutamine-N5) methyltransferase activity
LGI35_RS06135	COG2409	Drug exporters of the RND superfamily
LGI35_RS06140	COG0483	inositol monophosphate 1-phosphatase activity
LGI35_RS06145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS06150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS06170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS06175	COG2957	Belongs to the agmatine deiminase family
LGI35_RS06180	COG2957	Belongs to the agmatine deiminase family
LGI35_RS06200	COG0832	Belongs to the urease beta subunit family
LGI35_RS06200	COG0831	urea catabolic process
LGI35_RS06205	COG0804	urea catabolic process
LGI35_RS06210	COG2957	Belongs to the agmatine deiminase family
LGI35_RS06215	COG0747	negative chemotaxis
LGI35_RS06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS06230	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS06235	COG4172	Belongs to the ABC transporter superfamily
LGI35_RS06240	COG2957	Belongs to the agmatine deiminase family
LGI35_RS06270	COG1090	epimerase
LGI35_RS06310	COG1686	Belongs to the peptidase S11 family
LGI35_RS06320	COG0531	amino acid
LGI35_RS06325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LGI35_RS06335	COG1309	transcriptional regulator
LGI35_RS06350	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS06360	COG3511	phospholipase C
LGI35_RS06370	COG0531	amino acid
LGI35_RS06375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LGI35_RS06405	COG0477	Major facilitator Superfamily
LGI35_RS06410	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS06420	COG1191	sigma factor activity
LGI35_RS06455	COG2723	6-phospho-beta-galactosidase activity
LGI35_RS06460	COG0395	ABC-type sugar transport system, permease component
LGI35_RS06465	COG1175	transmembrane transport
LGI35_RS06470	COG1653	transport
LGI35_RS06475	COG1940	carbohydrate kinase activity
LGI35_RS06500	COG0019	diaminopimelate decarboxylase activity
LGI35_RS06510	COG0531	amino acid
LGI35_RS06530	COG4106	trans-aconitate 2-methyltransferase activity
LGI35_RS06545	COG3835	regulator
LGI35_RS06550	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS06590	COG0583	DNA-binding transcription factor activity
LGI35_RS06670	COG1609	Transcriptional regulator
LGI35_RS06675	COG2017	converts alpha-aldose to the beta-anomer
LGI35_RS06680	COG1879	ABC-type sugar transport system periplasmic component
LGI35_RS06685	COG1129	ABC transporter
LGI35_RS06690	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS06695	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS06710	COG0666	response to abiotic stimulus
LGI35_RS06745	COG0477	Major facilitator Superfamily
LGI35_RS06750	COG2030	dehydratase
LGI35_RS06755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS06770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LGI35_RS06770	COG0723	plastoquinol--plastocyanin reductase activity
LGI35_RS06790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS06805	COG0583	DNA-binding transcription factor activity
LGI35_RS06820	COG0590	tRNA wobble adenosine to inosine editing
LGI35_RS06835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LGI35_RS06870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LGI35_RS06875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LGI35_RS06880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LGI35_RS06890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LGI35_RS06940	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LGI35_RS06940	COG2066	Belongs to the glutaminase family
LGI35_RS06945	COG1177	transmembrane transport
LGI35_RS06950	COG1176	ABC-type spermidine putrescine transport system, permease component I
LGI35_RS06955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LGI35_RS06960	COG3842	ATPase activity
LGI35_RS06985	COG2267	carboxylic ester hydrolase activity
LGI35_RS07045	COG0725	ABC transporter, periplasmic molybdate-binding protein
LGI35_RS07090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS07100	COG1309	transcriptional regulator
LGI35_RS07105	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS07110	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS07115	COG0477	Major facilitator Superfamily
LGI35_RS07120	COG1473	amidohydrolase
LGI35_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS07145	COG0242	peptide deformylase activity
LGI35_RS07160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LGI35_RS07170	COG0277	FAD linked oxidase domain protein
LGI35_RS07175	COG1609	Transcriptional regulator
LGI35_RS07185	COG1175	transmembrane transport
LGI35_RS07190	COG0395	ABC-type sugar transport system, permease component
LGI35_RS07195	COG1472	Belongs to the glycosyl hydrolase 3 family
LGI35_RS07215	COG2353	YceI-like domain
LGI35_RS07225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LGI35_RS07230	COG0675	Transposase, IS605 OrfB family
LGI35_RS07265	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS07270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LGI35_RS07270	COG2010	Cytochrome c
LGI35_RS07295	COG0181	hydroxymethylbilane synthase activity
LGI35_RS07315	COG3634	alkyl hydroperoxide reductase activity
LGI35_RS07330	COG0477	Major facilitator Superfamily
LGI35_RS07360	COG2271	Major facilitator Superfamily
LGI35_RS07365	COG1802	Transcriptional regulator
LGI35_RS07385	COG1737	Transcriptional regulator
LGI35_RS07395	COG1126	abc transporter atp-binding protein
LGI35_RS07400	COG0765	amino acid transport
LGI35_RS07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGI35_RS07415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LGI35_RS07450	COG2182	Extracellular solute-binding protein
LGI35_RS07460	COG1175	transmembrane transport
LGI35_RS07465	COG1846	Transcriptional regulator
LGI35_RS07465	COG1940	carbohydrate kinase activity
LGI35_RS07470	COG1051	belongs to the nudix hydrolase family
LGI35_RS07475	COG0501	Belongs to the peptidase M48B family
LGI35_RS07495	COG2837	iron assimilation
LGI35_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS07570	COG1653	transport
LGI35_RS07575	COG1175	transmembrane transport
LGI35_RS07585	COG0366	Alpha amylase catalytic
LGI35_RS07625	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS07630	COG1129	ABC transporter
LGI35_RS07635	COG1846	Transcriptional regulator
LGI35_RS07635	COG1940	carbohydrate kinase activity
LGI35_RS07670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LGI35_RS07685	COG1024	Enoyl-CoA hydratase
LGI35_RS07705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LGI35_RS07710	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS07720	COG2070	2-Nitropropane dioxygenase
LGI35_RS07725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LGI35_RS07735	COG1609	Transcriptional regulator
LGI35_RS07745	COG1175	transmembrane transport
LGI35_RS07750	COG0395	ABC-type sugar transport system, permease component
LGI35_RS07785	COG3458	cephalosporin-C deacetylase activity
LGI35_RS07795	COG0515	serine threonine protein kinase
LGI35_RS07805	COG2814	Major facilitator Superfamily
LGI35_RS07815	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS07820	COG0454	-acetyltransferase
LGI35_RS07820	COG0456	acetyltransferase
LGI35_RS07835	COG3189	MarR family transcriptional regulator
LGI35_RS07840	COG0531	amino acid
LGI35_RS07855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LGI35_RS07865	COG1309	transcriptional regulator
LGI35_RS07870	COG1946	Acyl-CoA thioesterase
LGI35_RS07890	COG2318	DinB family
LGI35_RS07900	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS07905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LGI35_RS07910	COG1309	transcriptional regulator
LGI35_RS07925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LGI35_RS07930	COG1295	ribonuclease BN
LGI35_RS07940	COG3226	Transcriptional regulator
LGI35_RS08005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LGI35_RS08045	COG2376	Dihydroxyacetone kinase
LGI35_RS08050	COG1461	Dihydroxyacetone kinase
LGI35_RS08060	COG4733	cellulase activity
LGI35_RS08060	COG5297	Belongs to the glycosyl hydrolase family 6
LGI35_RS08075	COG0446	pyridine nucleotide-disulphide oxidoreductase
LGI35_RS08075	COG1902	pentaerythritol trinitrate reductase activity
LGI35_RS08095	COG0242	peptide deformylase activity
LGI35_RS08105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LGI35_RS08110	COG5002	protein histidine kinase activity
LGI35_RS08170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LGI35_RS08180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LGI35_RS08185	COG0640	Transcriptional regulator
LGI35_RS08190	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LGI35_RS08275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LGI35_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS08350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LGI35_RS08355	COG1215	transferase activity, transferring glycosyl groups
LGI35_RS08380	COG0464	growth
LGI35_RS08390	COG1349	DNA-binding transcription factor activity
LGI35_RS08415	COG0577	efflux transmembrane transporter activity
LGI35_RS08420	COG1136	(ABC) transporter
LGI35_RS08450	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS08460	COG0549	Belongs to the carbamate kinase family
LGI35_RS08465	COG2508	Transcriptional regulator
LGI35_RS08470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LGI35_RS08475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LGI35_RS08490	COG1940	carbohydrate kinase activity
LGI35_RS08505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LGI35_RS08510	COG1349	DNA-binding transcription factor activity
LGI35_RS08515	COG2223	nitrite transmembrane transporter activity
LGI35_RS08535	COG2197	response regulator
LGI35_RS08540	COG4585	Histidine kinase
LGI35_RS08555	COG0445	tRNA wobble uridine modification
LGI35_RS08570	COG1660	Displays ATPase and GTPase activities
LGI35_RS08585	COG0395	ABC-type sugar transport system, permease component
LGI35_RS08590	COG1175	transmembrane transport
LGI35_RS08600	COG3345	alpha-galactosidase
LGI35_RS08620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LGI35_RS08645	COG0204	Acyl-transferase
LGI35_RS08675	COG0657	acetylesterase activity
LGI35_RS08680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS08690	COG0584	glycerophosphoryl diester phosphodiesterase
LGI35_RS08705	COG0446	pyridine nucleotide-disulphide oxidoreductase
LGI35_RS08750	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LGI35_RS08755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LGI35_RS08770	COG1846	Transcriptional regulator
LGI35_RS08790	COG0671	phosphoesterase, PA-phosphatase related
LGI35_RS08805	COG1309	transcriptional regulator
LGI35_RS08825	COG2233	PERMEase
LGI35_RS08830	COG0640	Transcriptional regulator
LGI35_RS08835	COG1902	pentaerythritol trinitrate reductase activity
LGI35_RS08840	COG0254	rRNA binding
LGI35_RS08850	COG1940	carbohydrate kinase activity
LGI35_RS08855	COG4166	transmembrane transport
LGI35_RS08865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS08880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LGI35_RS08900	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
LGI35_RS08910	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS08930	COG2838	Isocitrate dehydrogenase
LGI35_RS08935	COG1522	sequence-specific DNA binding
LGI35_RS08940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LGI35_RS08970	COG2235	arginine
LGI35_RS08995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LGI35_RS09000	COG0513	Belongs to the DEAD box helicase family
LGI35_RS09005	COG1278	Cold shock
LGI35_RS09010	COG1902	pentaerythritol trinitrate reductase activity
LGI35_RS09025	COG3608	succinylglutamate desuccinylase aspartoacylase
LGI35_RS09025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LGI35_RS09030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LGI35_RS09035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LGI35_RS09040	COG2080	2 iron, 2 sulfur cluster binding
LGI35_RS09115	COG2271	Major facilitator Superfamily
LGI35_RS09120	COG1063	alcohol dehydrogenase
LGI35_RS09125	COG0246	Mannitol dehydrogenase
LGI35_RS09160	COG0432	Pfam Uncharacterised protein family UPF0047
LGI35_RS09165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LGI35_RS09170	COG1116	anion transmembrane transporter activity
LGI35_RS09195	COG1132	(ABC) transporter
LGI35_RS09200	COG1846	Transcriptional regulator
LGI35_RS09215	COG1301	dicarboxylic acid transport
LGI35_RS09230	COG1132	(ABC) transporter
LGI35_RS09235	COG1132	(ABC) transporter
LGI35_RS09250	COG1946	Acyl-CoA thioesterase
LGI35_RS09265	COG2018	Roadblock/LC7 domain
LGI35_RS09335	COG3239	Fatty acid desaturase
LGI35_RS09340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LGI35_RS09355	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS09365	COG0242	peptide deformylase activity
LGI35_RS09375	COG1492	cobalamin metabolic process
LGI35_RS09380	COG0205	6-phosphofructokinase activity
LGI35_RS09400	COG0204	Acyl-transferase
LGI35_RS09410	COG0829	nickel cation binding
LGI35_RS09415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LGI35_RS09420	COG0830	nickel cation binding
LGI35_RS09425	COG0804	urea catabolic process
LGI35_RS09430	COG0832	Belongs to the urease beta subunit family
LGI35_RS09435	COG0831	urea catabolic process
LGI35_RS09450	COG0740	serine-type endopeptidase activity
LGI35_RS09490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LGI35_RS09495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LGI35_RS09500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LGI35_RS09515	COG1136	(ABC) transporter
LGI35_RS09520	COG0577	efflux transmembrane transporter activity
LGI35_RS09530	COG0456	acetyltransferase
LGI35_RS09550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LGI35_RS09555	COG3663	DNA glycosylase
LGI35_RS09580	COG4585	Histidine kinase
LGI35_RS09585	COG2197	response regulator
LGI35_RS09590	COG1940	carbohydrate kinase activity
LGI35_RS09595	COG2188	Transcriptional regulator
LGI35_RS09600	COG1595	DNA-templated transcription, initiation
LGI35_RS09615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS09630	COG0626	cystathionine gamma-synthase activity
LGI35_RS09650	COG1522	sequence-specific DNA binding
LGI35_RS09655	COG0419	ATPase involved in DNA repair
LGI35_RS09660	COG0420	3'-5' exonuclease activity
LGI35_RS09665	COG1739	Uncharacterized protein family UPF0029
LGI35_RS09685	COG1832	CoA-binding protein
LGI35_RS09715	COG0110	maltose O-acetyltransferase activity
LGI35_RS09765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LGI35_RS09780	COG0183	Belongs to the thiolase family
LGI35_RS09790	COG1968	undecaprenyl-diphosphatase activity
LGI35_RS09815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LGI35_RS09840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LGI35_RS09850	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS09890	COG0697	spore germination
LGI35_RS09965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LGI35_RS09965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LGI35_RS09975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LGI35_RS10015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LGI35_RS10045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LGI35_RS10055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LGI35_RS10070	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LGI35_RS10080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LGI35_RS10090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LGI35_RS10095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LGI35_RS10130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LGI35_RS10135	COG2146	nitrite reductase [NAD(P)H] activity
LGI35_RS10140	COG1414	Transcriptional regulator
LGI35_RS10150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LGI35_RS10160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LGI35_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS10175	COG0531	amino acid
LGI35_RS10205	COG2814	Major facilitator Superfamily
LGI35_RS10210	COG4336	lyase activity
LGI35_RS10215	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LGI35_RS10220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LGI35_RS10225	COG1984	allophanate hydrolase subunit 2
LGI35_RS10235	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS10265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS10270	COG2364	Membrane
LGI35_RS10280	COG2270	Major facilitator Superfamily
LGI35_RS10290	COG3030	protein affecting phage T7 exclusion by the F plasmid
LGI35_RS10295	COG0463	Glycosyl transferase, family 2
LGI35_RS10330	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS10380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LGI35_RS10385	COG0140	phosphoribosyl-ATP diphosphatase activity
LGI35_RS10390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LGI35_RS10395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LGI35_RS10395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LGI35_RS10400	COG3201	nicotinamide mononucleotide transporter
LGI35_RS10415	COG1846	Transcriptional regulator
LGI35_RS10415	COG1940	carbohydrate kinase activity
LGI35_RS10420	COG0738	Major facilitator superfamily
LGI35_RS10435	COG2233	PERMEase
LGI35_RS10460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LGI35_RS10470	COG0531	amino acid
LGI35_RS10490	COG2390	Transcriptional regulator
LGI35_RS10495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LGI35_RS10505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LGI35_RS10520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LGI35_RS10535	COG0194	GDP metabolic process
LGI35_RS10545	COG0284	orotidine-5'-phosphate decarboxylase activity
LGI35_RS10550	COG0167	dihydroorotate dehydrogenase activity
LGI35_RS10555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LGI35_RS10560	COG0505	Belongs to the CarA family
LGI35_RS10570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LGI35_RS10575	COG0540	Belongs to the ATCase OTCase family
LGI35_RS10580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LGI35_RS10590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LGI35_RS10595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LGI35_RS10600	COG0006	proline dipeptidase activity
LGI35_RS10610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LGI35_RS10615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LGI35_RS10620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LGI35_RS10625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LGI35_RS10635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LGI35_RS10640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LGI35_RS10660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LGI35_RS10675	COG0124	histidyl-tRNA synthetase
LGI35_RS10685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LGI35_RS10690	COG1196	nuclear chromosome segregation
LGI35_RS10695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LGI35_RS10700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LGI35_RS10705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LGI35_RS10710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LGI35_RS10720	COG2255	four-way junction helicase activity
LGI35_RS10725	COG0632	four-way junction helicase activity
LGI35_RS10730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LGI35_RS10735	COG0217	transcriptional regulatory protein
LGI35_RS10740	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LGI35_RS10745	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LGI35_RS10755	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS10760	COG1560	Kdo2-lipid A biosynthetic process
LGI35_RS10765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LGI35_RS10785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LGI35_RS10790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LGI35_RS10805	COG2176	DNA-directed DNA polymerase activity
LGI35_RS10805	COG5002	protein histidine kinase activity
LGI35_RS10925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LGI35_RS10925	COG1648	precorrin-2 dehydrogenase activity
LGI35_RS10930	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LGI35_RS10945	COG1464	Belongs to the NlpA lipoprotein family
LGI35_RS10950	COG1464	Belongs to the NlpA lipoprotein family
LGI35_RS10955	COG2011	ABC-type metal ion transport system permease component
LGI35_RS10960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LGI35_RS10985	COG0584	glycerophosphoryl diester phosphodiesterase
LGI35_RS10995	COG0477	Major facilitator Superfamily
LGI35_RS11015	COG0714	Associated with various cellular activities
LGI35_RS11030	COG0165	Argininosuccinate lyase
LGI35_RS11045	COG0385	Bile acid
LGI35_RS11050	COG1438	arginine binding
LGI35_RS11055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LGI35_RS11060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LGI35_RS11065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LGI35_RS11070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LGI35_RS11090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS11095	COG0697	spore germination
LGI35_RS11105	COG1649	PFAM Uncharacterised BCR, COG1649
LGI35_RS11135	COG0072	phenylalanine-tRNA ligase activity
LGI35_RS11135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LGI35_RS11140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LGI35_RS11145	COG5002	protein histidine kinase activity
LGI35_RS11150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LGI35_RS11155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LGI35_RS11160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LGI35_RS11165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LGI35_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS11215	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS11220	COG0174	glutamine synthetase
LGI35_RS11230	COG0531	amino acid
LGI35_RS11235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LGI35_RS11250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LGI35_RS11265	COG0517	IMP dehydrogenase activity
LGI35_RS11265	COG4175	Glycine betaine
LGI35_RS11270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LGI35_RS11340	COG0805	protein transport
LGI35_RS11345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LGI35_RS11365	COG2378	regulation of single-species biofilm formation
LGI35_RS11380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LGI35_RS11390	COG1609	Transcriptional regulator
LGI35_RS11395	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LGI35_RS11400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LGI35_RS11415	COG4122	O-methyltransferase activity
LGI35_RS11420	COG1222	aaa ATPase
LGI35_RS11440	COG1994	Peptidase M50
LGI35_RS11440	COG0517	IMP dehydrogenase activity
LGI35_RS11450	COG2197	response regulator
LGI35_RS11460	COG4166	transmembrane transport
LGI35_RS11465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LGI35_RS11470	COG1410	methionine synthase
LGI35_RS11470	COG0646	methionine synthase
LGI35_RS11475	COG1414	Transcriptional regulator
LGI35_RS11480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LGI35_RS11485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LGI35_RS11490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LGI35_RS11495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS11500	COG1846	Transcriptional regulator
LGI35_RS11525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LGI35_RS11535	COG2814	Major facilitator Superfamily
LGI35_RS11540	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS11565	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS11600	COG2186	Transcriptional regulator
LGI35_RS11610	COG0215	cysteine-tRNA ligase activity
LGI35_RS11630	COG0406	alpha-ribazole phosphatase activity
LGI35_RS11635	COG0598	Magnesium transport protein CorA
LGI35_RS11645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS11650	COG0667	Aldo Keto reductase
LGI35_RS11680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LGI35_RS11690	COG1940	carbohydrate kinase activity
LGI35_RS11695	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS11700	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS11710	COG0601	transmembrane transport
LGI35_RS11715	COG4166	transmembrane transport
LGI35_RS11725	COG3469	chitinase activity
LGI35_RS11730	COG0588	phosphoglycerate mutase activity
LGI35_RS11735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LGI35_RS11740	COG0166	Belongs to the GPI family
LGI35_RS11755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LGI35_RS11775	COG1175	transmembrane transport
LGI35_RS11780	COG0395	ABC-type sugar transport system, permease component
LGI35_RS11785	COG1609	Transcriptional regulator
LGI35_RS11800	COG3012	SEC-C Motif Domain Protein
LGI35_RS11805	COG2186	Transcriptional regulator
LGI35_RS11810	COG3265	gluconokinase activity
LGI35_RS11820	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS11825	COG1063	alcohol dehydrogenase
LGI35_RS11850	COG3573	Dehydrogenase
LGI35_RS11860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LGI35_RS11865	COG2149	membrane
LGI35_RS11890	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS11900	COG3876	Protein conserved in bacteria
LGI35_RS11905	COG0477	Major facilitator Superfamily
LGI35_RS11930	COG1131	(ABC) transporter
LGI35_RS11935	COG4585	Histidine kinase
LGI35_RS11940	COG2197	response regulator
LGI35_RS11955	COG1309	transcriptional regulator
LGI35_RS11965	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS11975	COG0640	Transcriptional regulator
LGI35_RS11985	COG0477	Major facilitator Superfamily
LGI35_RS12000	COG1404	Belongs to the peptidase S8 family
LGI35_RS12000	COG4412	M6 family metalloprotease domain protein
LGI35_RS12010	COG1404	Belongs to the peptidase S8 family
LGI35_RS12010	COG4412	M6 family metalloprotease domain protein
LGI35_RS12030	COG2851	Citrate transporter
LGI35_RS12035	COG1309	transcriptional regulator
LGI35_RS12040	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LGI35_RS12045	COG2188	Transcriptional regulator
LGI35_RS12080	COG0515	serine threonine protein kinase
LGI35_RS12085	COG2755	lipolytic protein G-D-S-L family
LGI35_RS12110	COG1649	PFAM Uncharacterised BCR, COG1649
LGI35_RS12110	COG0726	polysaccharide deacetylase
LGI35_RS12130	COG1725	Transcriptional regulator
LGI35_RS12195	COG0587	DNA-directed DNA polymerase activity
LGI35_RS12230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS12235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGI35_RS12240	COG1126	abc transporter atp-binding protein
LGI35_RS12255	COG0765	amino acid transport
LGI35_RS12260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGI35_RS12270	COG1799	cell septum assembly
LGI35_RS12275	COG0477	Major facilitator Superfamily
LGI35_RS12285	COG0671	phosphoesterase, PA-phosphatase related
LGI35_RS12310	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS12315	COG3583	domain protein
LGI35_RS12330	COG1160	GTP binding
LGI35_RS12340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LGI35_RS12365	COG3541	Predicted nucleotidyltransferase
LGI35_RS12380	COG1187	pseudouridine synthase activity
LGI35_RS12385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LGI35_RS12390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LGI35_RS12405	COG0686	Belongs to the AlaDH PNT family
LGI35_RS12415	COG0494	nUDIX hydrolase
LGI35_RS12420	COG0504	CTP synthase activity
LGI35_RS12425	COG3387	PFAM Glycoside hydrolase 15-related
LGI35_RS12435	COG0297	glycogen (starch) synthase activity
LGI35_RS12445	COG0497	DNA recombination
LGI35_RS12455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LGI35_RS12475	COG1120	ATPase activity
LGI35_RS12480	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LGI35_RS12485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LGI35_RS12490	COG0647	UMP catabolic process
LGI35_RS12525	COG2094	Belongs to the DNA glycosylase MPG family
LGI35_RS12535	COG1881	PFAM PEBP family protein
LGI35_RS12555	COG1119	ATPase activity
LGI35_RS12575	COG2197	response regulator
LGI35_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS12590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LGI35_RS12600	COG1131	(ABC) transporter
LGI35_RS12600	COG0842	Transport permease protein
LGI35_RS12600	COG1716	ATPase activity
LGI35_RS12610	COG3830	Belongs to the UPF0237 family
LGI35_RS12610	COG0560	Phosphoserine phosphatase
LGI35_RS12630	COG2186	Transcriptional regulator
LGI35_RS12640	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LGI35_RS12660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LGI35_RS12665	COG2261	transglycosylase associated protein
LGI35_RS12680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LGI35_RS12685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LGI35_RS12705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS12715	COG1063	alcohol dehydrogenase
LGI35_RS12760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LGI35_RS12775	COG3387	PFAM Glycoside hydrolase 15-related
LGI35_RS12825	COG0488	(ABC) transporter
LGI35_RS12845	COG2267	carboxylic ester hydrolase activity
LGI35_RS12850	COG0235	Class ii aldolase
LGI35_RS12870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LGI35_RS12875	COG1492	cobalamin metabolic process
LGI35_RS12895	COG1797	cobyrinic acid a,c-diamide synthase activity
LGI35_RS12945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LGI35_RS12950	COG0456	acetyltransferase
LGI35_RS12955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LGI35_RS12960	COG1917	Cupin 2, conserved barrel domain protein
LGI35_RS12970	COG1902	pentaerythritol trinitrate reductase activity
LGI35_RS12975	COG1846	Transcriptional regulator
LGI35_RS13005	COG1414	Transcriptional regulator
LGI35_RS13015	COG4585	Histidine kinase
LGI35_RS13020	COG2197	response regulator
LGI35_RS13025	COG0768	penicillin binding
LGI35_RS13035	COG2252	PERMEase
LGI35_RS13070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS13075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LGI35_RS13090	COG1349	DNA-binding transcription factor activity
LGI35_RS13105	COG0395	ABC-type sugar transport system, permease component
LGI35_RS13110	COG1063	alcohol dehydrogenase
LGI35_RS13125	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LGI35_RS13130	COG1802	Transcriptional regulator
LGI35_RS13135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LGI35_RS13135	COG0515	serine threonine protein kinase
LGI35_RS13190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS13200	COG1595	DNA-templated transcription, initiation
LGI35_RS13215	COG2171	N-acyltransferase activity
LGI35_RS13220	COG3226	Transcriptional regulator
LGI35_RS13225	COG2076	Multidrug Resistance protein
LGI35_RS13250	COG0822	iron-sulfur transferase activity
LGI35_RS13255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LGI35_RS13260	COG0396	ATPase activity
LGI35_RS13270	COG0719	Fe-S assembly protein
LGI35_RS13285	COG1131	(ABC) transporter
LGI35_RS13295	COG1612	heme a metabolic process
LGI35_RS13310	COG0109	protoheme IX farnesyltransferase activity
LGI35_RS13320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LGI35_RS13335	COG0363	glucosamine-6-phosphate deaminase activity
LGI35_RS13345	COG0166	Belongs to the GPI family
LGI35_RS13355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LGI35_RS13360	COG0149	triose-phosphate isomerase activity
LGI35_RS13365	COG0126	phosphoglycerate kinase activity
LGI35_RS13370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LGI35_RS13380	COG1481	regulation of sporulation
LGI35_RS13385	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LGI35_RS13390	COG1660	Displays ATPase and GTPase activities
LGI35_RS13395	COG0322	excinuclease ABC activity
LGI35_RS13405	COG0723	plastoquinol--plastocyanin reductase activity
LGI35_RS13425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LGI35_RS13435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LGI35_RS13445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LGI35_RS13450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LGI35_RS13455	COG0387	Pfam Sodium calcium exchanger
LGI35_RS13475	COG0556	nucleotide-excision repair
LGI35_RS13485	COG0584	glycerophosphoryl diester phosphodiesterase
LGI35_RS13490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LGI35_RS13510	COG2313	pseudouridylate synthase activity
LGI35_RS13515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LGI35_RS13515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LGI35_RS13520	COG2226	methyltransferase
LGI35_RS13525	COG0598	Magnesium transport protein CorA
LGI35_RS13555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LGI35_RS13560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS13620	COG1288	antiporter activity
LGI35_RS13640	COG2226	methyltransferase
LGI35_RS13665	COG0237	dephospho-CoA kinase activity
LGI35_RS13685	COG2226	methyltransferase
LGI35_RS13690	COG1643	Atp-dependent helicase
LGI35_RS13725	COG2050	protein possibly involved in aromatic compounds catabolism
LGI35_RS13780	COG0737	Belongs to the 5'-nucleotidase family
LGI35_RS13800	COG1605	Chorismate mutase
LGI35_RS13800	COG0287	Prephenate dehydrogenase
LGI35_RS13825	COG1053	succinate dehydrogenase
LGI35_RS13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LGI35_RS13840	COG2267	carboxylic ester hydrolase activity
LGI35_RS13845	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS13880	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LGI35_RS13885	COG3971	2-oxopent-4-enoate hydratase activity
LGI35_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS13900	COG1024	Enoyl-CoA hydratase
LGI35_RS13915	COG2070	2-Nitropropane dioxygenase
LGI35_RS13920	COG2365	Tyrosine phosphatase family
LGI35_RS13925	COG0513	Belongs to the DEAD box helicase family
LGI35_RS13930	COG1278	Cold shock
LGI35_RS13935	COG0183	Belongs to the thiolase family
LGI35_RS13940	COG1309	transcriptional regulator
LGI35_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS13950	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS13955	COG1024	Enoyl-CoA hydratase
LGI35_RS13960	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS13975	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS13980	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS13985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LGI35_RS13995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS14005	COG0657	acetylesterase activity
LGI35_RS14030	COG0070	glutamate synthase
LGI35_RS14030	COG0069	glutamate synthase activity
LGI35_RS14030	COG0067	glutamate synthase
LGI35_RS14060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS14065	COG2301	Belongs to the HpcH HpaI aldolase family
LGI35_RS14070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LGI35_RS14080	COG0159	tryptophan synthase activity
LGI35_RS14085	COG0133	tryptophan synthase activity
LGI35_RS14090	COG0134	indole-3-glycerol-phosphate synthase activity
LGI35_RS14115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LGI35_RS14135	COG0107	imidazoleglycerol-phosphate synthase activity
LGI35_RS14140	COG0251	oxidation-reduction process
LGI35_RS14145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LGI35_RS14150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LGI35_RS14160	COG0131	Imidazoleglycerol-phosphate dehydratase
LGI35_RS14165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LGI35_RS14170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LGI35_RS14190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LGI35_RS14210	COG1432	Conserved Protein
LGI35_RS14220	COG0587	DNA-directed DNA polymerase activity
LGI35_RS14270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LGI35_RS14285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LGI35_RS14300	COG1799	cell septum assembly
LGI35_RS14310	COG1496	oxidoreductase activity
LGI35_RS14315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LGI35_RS14320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LGI35_RS14325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LGI35_RS14335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LGI35_RS14340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LGI35_RS14350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LGI35_RS14365	COG0275	rRNA processing
LGI35_RS14375	COG0714	Associated with various cellular activities
LGI35_RS14405	COG1126	abc transporter atp-binding protein
LGI35_RS14415	COG1309	transcriptional regulator
LGI35_RS14440	COG0352	thiamine-phosphate diphosphorylase activity
LGI35_RS14460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LGI35_RS14460	COG2022	thiamine diphosphate biosynthetic process
LGI35_RS14470	COG2022	thiamine diphosphate biosynthetic process
LGI35_RS14475	COG0515	serine threonine protein kinase
LGI35_RS14475	COG2815	serine threonine protein kinase
LGI35_RS14480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LGI35_RS14490	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LGI35_RS14495	COG2193	ferroxidase activity
LGI35_RS14500	COG0243	molybdopterin cofactor binding
LGI35_RS14505	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LGI35_RS14520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LGI35_RS14525	COG0205	6-phosphofructokinase activity
LGI35_RS14535	COG4585	Histidine kinase
LGI35_RS14560	COG1940	carbohydrate kinase activity
LGI35_RS14570	COG0003	Pfam Anion-transporting ATPase
LGI35_RS14590	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS14610	COG0791	NLP P60 protein
LGI35_RS14635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LGI35_RS14640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LGI35_RS14645	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LGI35_RS14650	COG0723	plastoquinol--plastocyanin reductase activity
LGI35_RS14655	COG2010	Cytochrome c
LGI35_RS14660	COG1845	cytochrome c oxidase, subunit III
LGI35_RS14670	COG1376	ErfK ybiS ycfS ynhG family protein
LGI35_RS14680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LGI35_RS14685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LGI35_RS14695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LGI35_RS14715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LGI35_RS14720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LGI35_RS14725	COG2197	response regulator
LGI35_RS14730	COG4585	Histidine kinase
LGI35_RS14750	COG2226	methyltransferase
LGI35_RS14770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LGI35_RS14790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LGI35_RS14795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LGI35_RS14800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LGI35_RS14805	COG0508	dehydrogenase complex catalyzes the overall conversion of
LGI35_RS14815	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LGI35_RS14845	COG2208	phosphoserine phosphatase activity
LGI35_RS14845	COG2770	Histidine kinase
LGI35_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS14880	COG0321	lipoyl(octanoyl) transferase activity
LGI35_RS14885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LGI35_RS14960	COG0745	RESPONSE REGULATOR receiver
LGI35_RS14975	COG2197	response regulator
LGI35_RS14995	COG2365	Tyrosine phosphatase family
LGI35_RS15040	COG0366	Alpha amylase catalytic
LGI35_RS15045	COG3833	ABC-type maltose transport systems, permease component
LGI35_RS15060	COG1609	Transcriptional regulator
LGI35_RS15070	COG1228	amidohydrolase
LGI35_RS15085	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LGI35_RS15095	COG3511	phospholipase C
LGI35_RS15110	COG0346	lactoylglutathione lyase activity
LGI35_RS15130	COG0174	glutamine synthetase
LGI35_RS15155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LGI35_RS15160	COG4209	transmembrane transport
LGI35_RS15165	COG0395	ABC-type sugar transport system, permease component
LGI35_RS15175	COG1609	Transcriptional regulator
LGI35_RS15180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LGI35_RS15180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LGI35_RS15185	COG2814	Major facilitator Superfamily
LGI35_RS15195	COG1309	transcriptional regulator
LGI35_RS15200	COG0477	Major facilitator Superfamily
LGI35_RS15205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LGI35_RS15225	COG1994	Peptidase M50
LGI35_RS15260	COG5398	heme oxygenase
LGI35_RS15265	COG0384	phenazine biosynthesis protein PhzF
LGI35_RS15275	COG2837	iron assimilation
LGI35_RS15280	COG0672	)-iron permease
LGI35_RS15310	COG1834	amidinotransferase
LGI35_RS15320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LGI35_RS15325	COG2814	Major facilitator Superfamily
LGI35_RS15335	COG3540	Alkaline phosphatase
LGI35_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS15350	COG0384	phenazine biosynthesis protein PhzF
LGI35_RS15360	COG2259	Doxx family
LGI35_RS15395	COG0557	exoribonuclease II activity
LGI35_RS15400	COG3022	response to hydroperoxide
LGI35_RS15405	COG0800	Aldolase
LGI35_RS15420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LGI35_RS15425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LGI35_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS15450	COG2030	dehydratase
LGI35_RS15455	COG1131	(ABC) transporter
LGI35_RS15465	COG4585	Histidine kinase
LGI35_RS15470	COG2197	response regulator
LGI35_RS15480	COG0183	Belongs to the thiolase family
LGI35_RS15485	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS15490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS15495	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS15500	COG0477	Major facilitator Superfamily
LGI35_RS15505	COG0583	DNA-binding transcription factor activity
LGI35_RS15510	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS15515	COG0477	Major facilitator Superfamily
LGI35_RS15520	COG3340	Belongs to the peptidase S51 family
LGI35_RS15525	COG1414	Transcriptional regulator
LGI35_RS15535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS15540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LGI35_RS15550	COG0860	N-Acetylmuramoyl-L-alanine amidase
LGI35_RS15550	COG2247	cell wall binding repeat
LGI35_RS15560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS15585	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS15590	COG1309	transcriptional regulator
LGI35_RS15605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LGI35_RS15615	COG2268	Band 7 protein
LGI35_RS15635	COG3845	ABC transporter
LGI35_RS15650	COG0183	Belongs to the thiolase family
LGI35_RS15655	COG2124	cytochrome p450
LGI35_RS15675	COG4122	O-methyltransferase activity
LGI35_RS15800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LGI35_RS15830	COG2186	Transcriptional regulator
LGI35_RS15840	COG0800	Aldolase
LGI35_RS15860	COG1358	cellular component organization or biogenesis
LGI35_RS15905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LGI35_RS15915	COG0477	Major facilitator Superfamily
LGI35_RS15920	COG1309	transcriptional regulator
LGI35_RS15935	COG4585	Histidine kinase
LGI35_RS15940	COG2197	response regulator
LGI35_RS15955	COG0667	Aldo Keto reductase
LGI35_RS15960	COG0789	Transcriptional regulator
LGI35_RS15970	COG1741	Belongs to the pirin family
LGI35_RS15985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LGI35_RS15990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LGI35_RS15995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LGI35_RS16040	COG1764	response to oxidative stress
LGI35_RS16045	COG2130	NADP-dependent
LGI35_RS16075	COG4213	ABC transporter substrate-binding protein
LGI35_RS16085	COG4214	carbohydrate transport
LGI35_RS16095	COG0395	ABC-type sugar transport system, permease component
LGI35_RS16100	COG1175	transmembrane transport
LGI35_RS16110	COG3386	PFAM SMP-30 Gluconolaconase
LGI35_RS16115	COG1414	Transcriptional regulator
LGI35_RS16125	COG1595	DNA-templated transcription, initiation
LGI35_RS16155	COG4981	capsule polysaccharide biosynthetic process
LGI35_RS16190	COG2186	Transcriptional regulator
LGI35_RS16195	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS16200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LGI35_RS16200	COG0825	malonyl-CoA metabolic process
LGI35_RS16205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS16210	COG1404	Belongs to the peptidase S8 family
LGI35_RS16220	COG0477	Major facilitator Superfamily
LGI35_RS16225	COG1077	Cell shape determining protein MreB Mrl
LGI35_RS16305	COG1070	Carbohydrate kinase
LGI35_RS16320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LGI35_RS16325	COG0358	DNA primase activity
LGI35_RS16335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LGI35_RS16345	COG2949	membrane
LGI35_RS16350	COG0243	molybdopterin cofactor binding
LGI35_RS16355	COG2259	Doxx family
LGI35_RS16385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LGI35_RS16390	COG2146	nitrite reductase [NAD(P)H] activity
LGI35_RS16390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LGI35_RS16400	COG1309	transcriptional regulator
LGI35_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS16410	COG0395	ABC-type sugar transport system, permease component
LGI35_RS16420	COG1653	transport
LGI35_RS16440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LGI35_RS16440	COG0574	Belongs to the PEP-utilizing enzyme family
LGI35_RS16450	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LGI35_RS16475	COG0477	Major facilitator Superfamily
LGI35_RS16480	COG0667	Aldo Keto reductase
LGI35_RS16510	COG0423	glycine-tRNA ligase activity
LGI35_RS16515	COG0803	Belongs to the bacterial solute-binding protein 9 family
LGI35_RS16515	COG3443	Belongs to the bacterial solute-binding protein 9 family
LGI35_RS16520	COG1121	(ABC) transporter
LGI35_RS16525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LGI35_RS16535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LGI35_RS16540	COG1381	Involved in DNA repair and RecF pathway recombination
LGI35_RS16545	COG1381	Involved in DNA repair and RecF pathway recombination
LGI35_RS16560	COG0747	negative chemotaxis
LGI35_RS16565	COG0601	transmembrane transport
LGI35_RS16575	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS16580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS16585	COG2197	response regulator
LGI35_RS16590	COG4585	Histidine kinase
LGI35_RS16595	COG2409	Drug exporters of the RND superfamily
LGI35_RS16605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LGI35_RS16640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LGI35_RS16660	COG2315	Protein conserved in bacteria
LGI35_RS16670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LGI35_RS16680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LGI35_RS16690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LGI35_RS16695	COG1234	tRNA 3'-trailer cleavage
LGI35_RS16700	COG0537	adenosine 5'-monophosphoramidase activity
LGI35_RS16705	COG4946	Tricorn protease homolog
LGI35_RS16705	COG0793	Belongs to the peptidase S41A family
LGI35_RS16725	COG0484	heat shock protein binding
LGI35_RS16730	COG1420	regulation of RNA biosynthetic process
LGI35_RS16770	COG0481	GTPase activity
LGI35_RS16775	COG0268	Binds directly to 16S ribosomal RNA
LGI35_RS16790	COG2353	YceI-like domain
LGI35_RS16795	COG1234	tRNA 3'-trailer cleavage
LGI35_RS16800	COG1555	photosystem II stabilization
LGI35_RS16805	COG1307	EDD domain protein, DegV family
LGI35_RS16815	COG0495	leucyl-tRNA aminoacylation
LGI35_RS16825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LGI35_RS16850	COG0588	phosphoglycerate mutase activity
LGI35_RS16855	COG0799	negative regulation of ribosome biogenesis
LGI35_RS16865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LGI35_RS16880	COG0501	Belongs to the peptidase M48B family
LGI35_RS16895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LGI35_RS16905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LGI35_RS16915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LGI35_RS16920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LGI35_RS16925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LGI35_RS16935	COG1530	ribonuclease E activity
LGI35_RS16965	COG0772	Belongs to the SEDS family
LGI35_RS16970	COG0768	penicillin binding
LGI35_RS16985	COG1077	Cell shape determining protein MreB Mrl
LGI35_RS16990	COG0105	UTP biosynthetic process
LGI35_RS17000	COG0285	dihydrofolate synthase activity
LGI35_RS17005	COG1077	Cell shape determining protein MreB Mrl
LGI35_RS17015	COG0525	valine-tRNA ligase activity
LGI35_RS17025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LGI35_RS17030	COG0740	serine-type endopeptidase activity
LGI35_RS17035	COG0740	serine-type endopeptidase activity
LGI35_RS17040	COG0544	peptidyl-prolyl cis-trans isomerase activity
LGI35_RS17060	COG3594	Acyltransferase
LGI35_RS17075	COG1136	(ABC) transporter
LGI35_RS17080	COG0475	glutathione-regulated potassium exporter activity
LGI35_RS17090	COG4552	Acetyltransferase involved in intracellular survival and related
LGI35_RS17105	COG1113	amino acid transport
LGI35_RS17115	COG1268	BioY protein
LGI35_RS17120	COG1113	amino acid transport
LGI35_RS17125	COG1113	amino acid transport
LGI35_RS17130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LGI35_RS17140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LGI35_RS17200	COG4266	Belongs to the allantoicase family
LGI35_RS17215	COG0697	spore germination
LGI35_RS17220	COG1846	Transcriptional regulator
LGI35_RS17225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LGI35_RS17250	COG3291	Pkd domain containing protein
LGI35_RS17250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LGI35_RS17255	COG0668	transmembrane transport
LGI35_RS17275	COG1131	(ABC) transporter
LGI35_RS17285	COG1595	DNA-templated transcription, initiation
LGI35_RS17290	COG1940	carbohydrate kinase activity
LGI35_RS17290	COG1846	Transcriptional regulator
LGI35_RS17300	COG1175	transmembrane transport
LGI35_RS17305	COG0395	ABC-type sugar transport system, permease component
LGI35_RS17310	COG1486	melibiose metabolic process
LGI35_RS17325	COG1595	DNA-templated transcription, initiation
LGI35_RS17340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGI35_RS17370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LGI35_RS17390	COG0577	efflux transmembrane transporter activity
LGI35_RS17390	COG1136	(ABC) transporter
LGI35_RS17420	COG0629	single-stranded DNA binding
LGI35_RS17425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LGI35_RS17460	COG3629	intracellular signal transduction
LGI35_RS17480	COG2409	Drug exporters of the RND superfamily
LGI35_RS17490	COG3963	phosphatidate phosphatase activity
LGI35_RS17530	COG2030	dehydratase
LGI35_RS17540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LGI35_RS17550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LGI35_RS17570	COG1309	transcriptional regulator
LGI35_RS17580	COG4989	oxidoreductase activity
LGI35_RS17585	COG1132	(ABC) transporter
LGI35_RS17605	COG1131	(ABC) transporter
LGI35_RS17625	COG3962	Belongs to the TPP enzyme family
LGI35_RS17630	COG3718	enzyme involved in inositol metabolism
LGI35_RS17640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LGI35_RS17655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LGI35_RS17685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LGI35_RS17700	COG1129	ABC transporter
LGI35_RS17705	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS17710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LGI35_RS17715	COG1869	D-ribose catabolic process
LGI35_RS17735	COG0673	inositol 2-dehydrogenase activity
LGI35_RS17740	COG1609	Transcriptional regulator
LGI35_RS17750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LGI35_RS17765	COG1472	Belongs to the glycosyl hydrolase 3 family
LGI35_RS17795	COG0028	Belongs to the TPP enzyme family
LGI35_RS17805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LGI35_RS17825	COG1946	Acyl-CoA thioesterase
LGI35_RS17835	COG1309	transcriptional regulator
LGI35_RS17840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LGI35_RS17855	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS17870	COG0076	glutamate decarboxylase activity
LGI35_RS17875	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LGI35_RS17905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LGI35_RS17925	COG4977	sequence-specific DNA binding
LGI35_RS17940	COG0582	viral genome integration into host DNA
LGI35_RS18000	COG5377	YqaJ viral recombinase family
LGI35_RS18010	COG5002	protein histidine kinase activity
LGI35_RS18010	COG2176	DNA-directed DNA polymerase activity
LGI35_RS18335	COG4106	trans-aconitate 2-methyltransferase activity
LGI35_RS18370	COG3979	chitinase
LGI35_RS18380	COG0745	RESPONSE REGULATOR receiver
LGI35_RS18405	COG0588	phosphoglycerate mutase activity
LGI35_RS18455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS18475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LGI35_RS18480	COG0154	amidase activity
LGI35_RS18495	COG0765	amino acid transport
LGI35_RS18500	COG0765	amino acid transport
LGI35_RS18505	COG1126	abc transporter atp-binding protein
LGI35_RS18520	COG2197	response regulator
LGI35_RS18535	COG0702	epimerase
LGI35_RS18540	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS18555	COG3397	chitin binding
LGI35_RS18560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LGI35_RS18560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LGI35_RS18580	COG2186	Transcriptional regulator
LGI35_RS18635	COG2188	Transcriptional regulator
LGI35_RS18645	COG1940	carbohydrate kinase activity
LGI35_RS18650	COG0673	inositol 2-dehydrogenase activity
LGI35_RS18655	COG4702	Belongs to the UPF0303 family
LGI35_RS18665	COG0706	membrane insertase activity
LGI35_RS18675	COG3764	Sortase (surface protein transpeptidase)
LGI35_RS18770	COG2271	Major facilitator Superfamily
LGI35_RS18775	COG2733	membrane
LGI35_RS18790	COG1131	(ABC) transporter
LGI35_RS18805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LGI35_RS18830	COG0477	Major facilitator Superfamily
LGI35_RS18850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LGI35_RS18860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LGI35_RS18865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGI35_RS18870	COG1263	PTS System
LGI35_RS18875	COG1263	PTS System
LGI35_RS18880	COG1234	tRNA 3'-trailer cleavage
LGI35_RS18905	COG1113	amino acid transport
LGI35_RS18915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LGI35_RS18925	COG1335	isochorismatase
LGI35_RS18960	COG0277	FAD linked oxidase domain protein
LGI35_RS18980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LGI35_RS18990	COG1174	glycine betaine transport
LGI35_RS18995	COG0517	IMP dehydrogenase activity
LGI35_RS18995	COG1125	glycine betaine transport
LGI35_RS19000	COG1174	glycine betaine transport
LGI35_RS19090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LGI35_RS19105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LGI35_RS19110	COG0395	ABC-type sugar transport system, permease component
LGI35_RS19130	COG1678	Uncharacterized ACR, COG1678
LGI35_RS19135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LGI35_RS19140	COG0776	regulation of translation
LGI35_RS19150	COG3973	AAA domain
LGI35_RS19200	COG0583	DNA-binding transcription factor activity
LGI35_RS19210	COG2027	D-alanyl-D-alanine carboxypeptidase
LGI35_RS19225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LGI35_RS19230	COG0793	Belongs to the peptidase S41A family
LGI35_RS19240	COG2884	Cell division ATP-binding protein ftsE
LGI35_RS19255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LGI35_RS19260	COG0515	serine threonine protein kinase
LGI35_RS19265	COG0515	serine threonine protein kinase
LGI35_RS19270	COG1674	ftsk spoiiie
LGI35_RS19275	COG1653	transport
LGI35_RS19280	COG1175	transmembrane transport
LGI35_RS19285	COG0395	ABC-type sugar transport system, permease component
LGI35_RS19290	COG0463	Glycosyl transferase, family 2
LGI35_RS19290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS19295	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS19300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS19305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS19310	COG4122	O-methyltransferase activity
LGI35_RS19335	COG1764	response to oxidative stress
LGI35_RS19340	COG1846	Transcriptional regulator
LGI35_RS19350	COG1215	transferase activity, transferring glycosyl groups
LGI35_RS19360	COG1309	transcriptional regulator
LGI35_RS19370	COG1388	LysM domain
LGI35_RS19370	COG1134	teichoic acid transport
LGI35_RS19375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS19380	COG1216	Glycosyl transferase, family 2
LGI35_RS19395	COG1216	Glycosyl transferase, family 2
LGI35_RS19405	COG2902	Dehydrogenase
LGI35_RS19410	COG0693	protein deglycase activity
LGI35_RS19435	COG0653	protein targeting
LGI35_RS19445	COG3214	Protein conserved in bacteria
LGI35_RS19450	COG2197	response regulator
LGI35_RS19455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LGI35_RS19465	COG0823	Involved in the tonB-independent uptake of proteins
LGI35_RS19470	COG5002	protein histidine kinase activity
LGI35_RS19470	COG5000	phosphorelay sensor kinase activity
LGI35_RS19475	COG0745	RESPONSE REGULATOR receiver
LGI35_RS19480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LGI35_RS19500	COG0714	Associated with various cellular activities
LGI35_RS19540	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LGI35_RS19550	COG1482	cell wall glycoprotein biosynthetic process
LGI35_RS19560	COG2835	tetraacyldisaccharide 4'-kinase activity
LGI35_RS19565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LGI35_RS19570	COG1620	l-lactate permease
LGI35_RS19605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LGI35_RS19610	COG0778	Nitroreductase
LGI35_RS19610	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LGI35_RS19635	COG1316	TRANSCRIPTIONal
LGI35_RS19655	COG1316	TRANSCRIPTIONal
LGI35_RS19660	COG1607	acyl-coa hydrolase
LGI35_RS19665	COG1316	TRANSCRIPTIONal
LGI35_RS19700	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LGI35_RS19725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LGI35_RS19740	COG2205	protein histidine kinase activity
LGI35_RS19745	COG0745	RESPONSE REGULATOR receiver
LGI35_RS19750	COG3104	oligopeptide transport
LGI35_RS19780	COG1366	Belongs to the anti-sigma-factor antagonist family
LGI35_RS19785	COG1191	sigma factor activity
LGI35_RS19790	COG1228	amidohydrolase
LGI35_RS19805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LGI35_RS19840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS19850	COG1174	glycine betaine transport
LGI35_RS19855	COG1174	glycine betaine transport
LGI35_RS19860	COG1125	glycine betaine transport
LGI35_RS19860	COG0517	IMP dehydrogenase activity
LGI35_RS19865	COG2986	histidine ammonia-lyase
LGI35_RS19880	COG2755	lipolytic protein G-D-S-L family
LGI35_RS19885	COG0183	Belongs to the thiolase family
LGI35_RS19910	COG2814	Major facilitator Superfamily
LGI35_RS19925	COG1136	(ABC) transporter
LGI35_RS19930	COG0577	efflux transmembrane transporter activity
LGI35_RS19935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LGI35_RS19960	COG0148	phosphopyruvate hydratase activity
LGI35_RS19970	COG1652	LysM domain
LGI35_RS19975	COG2124	cytochrome p450
LGI35_RS20030	COG0577	efflux transmembrane transporter activity
LGI35_RS20035	COG1136	(ABC) transporter
LGI35_RS20040	COG2814	Major facilitator Superfamily
LGI35_RS20050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LGI35_RS20080	COG4585	Histidine kinase
LGI35_RS20095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LGI35_RS20100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LGI35_RS20105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LGI35_RS20110	COG0193	aminoacyl-tRNA hydrolase activity
LGI35_RS20120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LGI35_RS20130	COG1309	transcriptional regulator
LGI35_RS20140	COG4106	trans-aconitate 2-methyltransferase activity
LGI35_RS20145	COG1846	Transcriptional regulator
LGI35_RS20150	COG2197	response regulator
LGI35_RS20160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LGI35_RS20200	COG0488	(ABC) transporter
LGI35_RS20215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LGI35_RS20220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LGI35_RS20230	COG0084	hydrolase, TatD family'
LGI35_RS20250	COG0768	penicillin binding
LGI35_RS20280	COG1122	ATPase activity
LGI35_RS20290	COG0310	cobalt ion transport
LGI35_RS20300	COG2409	Drug exporters of the RND superfamily
LGI35_RS20310	COG0793	Belongs to the peptidase S41A family
LGI35_RS20310	COG4946	Tricorn protease homolog
LGI35_RS20320	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS20325	COG2267	carboxylic ester hydrolase activity
LGI35_RS20330	COG2072	flavoprotein involved in K transport
LGI35_RS20345	COG0708	Exodeoxyribonuclease III
LGI35_RS20365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LGI35_RS20370	COG0315	cyclic pyranopterin monophosphate synthase activity
LGI35_RS20370	COG0521	Mo-molybdopterin cofactor biosynthetic process
LGI35_RS20375	COG0315	cyclic pyranopterin monophosphate synthase activity
LGI35_RS20385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LGI35_RS20390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LGI35_RS20400	COG3263	regulation of cellular component size
LGI35_RS20415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LGI35_RS20425	COG1970	mechanosensitive ion channel activity
LGI35_RS20435	COG3191	aminopeptidase activity
LGI35_RS20440	COG1376	ErfK ybiS ycfS ynhG family protein
LGI35_RS20480	COG1653	transport
LGI35_RS20485	COG0477	Major facilitator Superfamily
LGI35_RS20500	COG1247	-acetyltransferase
LGI35_RS20505	COG3384	dioxygenase
LGI35_RS20510	COG1846	Transcriptional regulator
LGI35_RS20640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LGI35_RS20655	COG1473	amidohydrolase
LGI35_RS20670	COG2267	carboxylic ester hydrolase activity
LGI35_RS20685	COG0277	FAD linked oxidase domain protein
LGI35_RS20690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LGI35_RS20695	COG1017	nitric oxide dioxygenase activity
LGI35_RS20695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LGI35_RS20710	COG1653	transport
LGI35_RS20720	COG1686	Belongs to the peptidase S11 family
LGI35_RS20760	COG2365	Tyrosine phosphatase family
LGI35_RS20770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LGI35_RS20805	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS20820	COG3629	intracellular signal transduction
LGI35_RS20820	COG3903	Transcriptional regulator
LGI35_RS20875	COG1024	Enoyl-CoA hydratase
LGI35_RS20890	COG0515	serine threonine protein kinase
LGI35_RS20890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LGI35_RS20900	COG1309	transcriptional regulator
LGI35_RS20910	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS20915	COG0183	Belongs to the thiolase family
LGI35_RS20955	COG2072	flavoprotein involved in K transport
LGI35_RS20965	COG1024	Enoyl-CoA hydratase
LGI35_RS20975	COG2814	Major facilitator Superfamily
LGI35_RS20985	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LGI35_RS20990	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS20995	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS21010	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS21015	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS21025	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS21095	COG4821	SIS domain
LGI35_RS21105	COG2945	thiolester hydrolase activity
LGI35_RS21105	COG0596	Alpha beta hydrolase
LGI35_RS21110	COG0259	pyridoxamine-phosphate oxidase activity
LGI35_RS21150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LGI35_RS21170	COG0583	DNA-binding transcription factor activity
LGI35_RS21175	COG0247	lactate metabolic process
LGI35_RS21175	COG0277	FAD linked oxidase domain protein
LGI35_RS21180	COG2124	cytochrome p450
LGI35_RS21185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LGI35_RS21200	COG0667	Aldo Keto reductase
LGI35_RS21230	COG2252	PERMEase
LGI35_RS21240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGI35_RS21260	COG2814	Major facilitator Superfamily
LGI35_RS21270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LGI35_RS21275	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LGI35_RS21295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LGI35_RS21300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LGI35_RS21305	COG1120	ATPase activity
LGI35_RS21310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LGI35_RS21325	COG1061	Type III restriction enzyme res subunit
LGI35_RS21345	COG3973	AAA domain
LGI35_RS21380	COG1737	Transcriptional regulator
LGI35_RS21385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LGI35_RS21390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGI35_RS21390	COG1263	PTS System
LGI35_RS21435	COG0459	protein refolding
LGI35_RS21455	COG0463	Glycosyl transferase, family 2
LGI35_RS21495	COG1105	Belongs to the carbohydrate kinase PfkB family
LGI35_RS21515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LGI35_RS21545	COG2197	response regulator
LGI35_RS21585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LGI35_RS21585	COG0723	plastoquinol--plastocyanin reductase activity
LGI35_RS21595	COG3842	ATPase activity
LGI35_RS21605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LGI35_RS21615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LGI35_RS21620	COG0215	cysteine-tRNA ligase activity
LGI35_RS21625	COG3467	pyridoxamine 5'-phosphate
LGI35_RS21630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LGI35_RS21635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LGI35_RS21640	COG1329	Transcriptional regulator
LGI35_RS21660	COG5002	protein histidine kinase activity
LGI35_RS21685	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS21705	COG0251	oxidation-reduction process
LGI35_RS21710	COG2368	4-hydroxyphenylacetate
LGI35_RS21715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LGI35_RS21725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS21740	COG0598	Magnesium transport protein CorA
LGI35_RS21745	COG0588	phosphoglycerate mutase activity
LGI35_RS21750	COG2814	Major facilitator Superfamily
LGI35_RS21765	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS21775	COG0791	NLP P60 protein
LGI35_RS21805	COG1595	DNA-templated transcription, initiation
LGI35_RS21810	COG0702	epimerase
LGI35_RS21825	COG3467	pyridoxamine 5'-phosphate
LGI35_RS21830	COG3973	AAA domain
LGI35_RS21860	COG2188	Transcriptional regulator
LGI35_RS21870	COG2188	Transcriptional regulator
LGI35_RS21880	COG4552	Acetyltransferase involved in intracellular survival and related
LGI35_RS21895	COG1490	D-aminoacyl-tRNA deacylase activity
LGI35_RS21900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LGI35_RS21905	COG0735	belongs to the Fur family
LGI35_RS21910	COG3485	protocatechuate 3,4-dioxygenase
LGI35_RS21965	COG2897	thiosulfate sulfurtransferase activity
LGI35_RS21990	COG0745	RESPONSE REGULATOR receiver
LGI35_RS21995	COG1609	Transcriptional regulator
LGI35_RS22005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LGI35_RS22010	COG0745	RESPONSE REGULATOR receiver
LGI35_RS22015	COG2205	protein histidine kinase activity
LGI35_RS22015	COG2972	Histidine kinase
LGI35_RS22025	COG0737	Belongs to the 5'-nucleotidase family
LGI35_RS22030	COG0456	acetyltransferase
LGI35_RS22035	COG1725	Transcriptional regulator
LGI35_RS22040	COG3842	ATPase activity
LGI35_RS22055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LGI35_RS22065	COG0494	nUDIX hydrolase
LGI35_RS22065	COG0406	alpha-ribazole phosphatase activity
LGI35_RS22070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LGI35_RS22085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LGI35_RS22090	COG0306	phosphate transporter
LGI35_RS22100	COG1937	Protein conserved in bacteria
LGI35_RS22120	COG0277	FAD linked oxidase domain protein
LGI35_RS22125	COG0671	phosphoesterase, PA-phosphatase related
LGI35_RS22130	COG1196	nuclear chromosome segregation
LGI35_RS22130	COG0739	heme binding
LGI35_RS22130	COG0741	lytic transglycosylase activity
LGI35_RS22170	COG1131	(ABC) transporter
LGI35_RS22180	COG4585	Histidine kinase
LGI35_RS22185	COG2197	response regulator
LGI35_RS22220	COG1252	NADH dehydrogenase
LGI35_RS22250	COG0579	oxidoreductase
LGI35_RS22255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LGI35_RS22265	COG0667	Aldo Keto reductase
LGI35_RS22290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGI35_RS22305	COG0513	Belongs to the DEAD box helicase family
LGI35_RS22345	COG1643	Atp-dependent helicase
LGI35_RS22370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LGI35_RS22380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LGI35_RS22400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LGI35_RS22405	COG0047	phosphoribosylformylglycinamidine synthase activity
LGI35_RS22410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LGI35_RS22445	COG2197	response regulator
LGI35_RS22455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LGI35_RS22470	COG0151	Belongs to the GarS family
LGI35_RS22525	COG0583	DNA-binding transcription factor activity
LGI35_RS22555	COG0433	COG0433 Predicted ATPase
LGI35_RS22570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LGI35_RS22605	COG1191	sigma factor activity
LGI35_RS22610	COG1191	sigma factor activity
LGI35_RS22635	COG2353	YceI-like domain
LGI35_RS22640	COG3467	pyridoxamine 5'-phosphate
LGI35_RS22660	COG0477	Major facilitator Superfamily
LGI35_RS22670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LGI35_RS22680	COG2205	protein histidine kinase activity
LGI35_RS22685	COG0745	RESPONSE REGULATOR receiver
LGI35_RS22695	COG2329	Antibiotic biosynthesis monooxygenase
LGI35_RS22730	COG0784	Response regulator, receiver
LGI35_RS22735	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS22740	COG1595	DNA-templated transcription, initiation
LGI35_RS22760	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS22770	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS22790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LGI35_RS22805	COG0653	protein targeting
LGI35_RS22825	COG0006	proline dipeptidase activity
LGI35_RS22845	COG1999	signal sequence binding
LGI35_RS22860	COG2837	iron assimilation
LGI35_RS22870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LGI35_RS22875	COG0561	phosphatase activity
LGI35_RS22900	COG1131	(ABC) transporter
LGI35_RS22920	COG0789	Transcriptional regulator
LGI35_RS22925	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LGI35_RS22935	COG0561	phosphatase activity
LGI35_RS22950	COG4988	ABC transporter
LGI35_RS22955	COG1294	oxidase, subunit
LGI35_RS22960	COG1271	oxidase subunit
LGI35_RS22965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LGI35_RS22970	COG1609	Transcriptional regulator
LGI35_RS22985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LGI35_RS23010	COG0662	Cupin 2, conserved barrel domain protein
LGI35_RS23015	COG1950	PFAM Membrane protein of
LGI35_RS23020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LGI35_RS23025	COG0626	cystathionine gamma-synthase activity
LGI35_RS23065	COG2814	Major facilitator Superfamily
LGI35_RS23085	COG0305	Participates in initiation and elongation during chromosome replication
LGI35_RS23090	COG0534	Mate efflux family protein
LGI35_RS23095	COG0359	binds to the 23S rRNA
LGI35_RS23100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LGI35_RS23105	COG0629	single-stranded DNA binding
LGI35_RS23110	COG0360	Binds together with S18 to 16S ribosomal RNA
LGI35_RS23135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LGI35_RS23145	COG1260	myo-inositol-1-phosphate synthase
LGI35_RS23160	COG0617	tRNA 3'-terminal CCA addition
LGI35_RS23175	COG2815	serine threonine protein kinase
LGI35_RS23175	COG0515	serine threonine protein kinase
LGI35_RS23180	COG1595	DNA-templated transcription, initiation
LGI35_RS23190	COG0492	ferredoxin-NADP+ reductase activity
LGI35_RS23195	COG3118	belongs to the thioredoxin family
LGI35_RS23210	COG1192	Involved in chromosome partitioning
LGI35_RS23215	COG0357	Ribosomal RNA small subunit methyltransferase G
LGI35_RS23225	COG0706	membrane insertase activity
LGI35_RS23230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LGI35_RS23235	COG0594	ribonuclease P activity
LGI35_RS23240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LGI35_RS23245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LGI35_RS23250	COG0592	DNA-directed DNA polymerase activity
LGI35_RS23255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LGI35_RS23260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LGI35_RS23265	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LGI35_RS23270	COG0187	DNA topoisomerase II activity
LGI35_RS23275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LGI35_RS23305	COG0515	serine threonine protein kinase
LGI35_RS23330	COG0457	Tetratricopeptide repeat
LGI35_RS23330	COG0705	Rhomboid family
LGI35_RS23345	COG3764	Sortase (surface protein transpeptidase)
LGI35_RS23360	COG3764	Sortase (surface protein transpeptidase)
LGI35_RS23365	COG3764	Sortase (surface protein transpeptidase)
LGI35_RS23370	COG0515	serine threonine protein kinase
LGI35_RS23390	COG1716	ATPase activity
LGI35_RS23395	COG1716	ATPase activity
LGI35_RS23405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LGI35_RS23410	COG1733	regulation of RNA biosynthetic process
LGI35_RS23435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LGI35_RS23440	COG2151	metal-sulfur cluster biosynthetic enzyme
LGI35_RS23445	COG3396	Phenylacetate-CoA oxygenase
LGI35_RS23450	COG3460	Phenylacetate-CoA oxygenase
LGI35_RS23455	COG3396	Phenylacetate-CoA oxygenase
LGI35_RS23480	COG1250	3-hydroxyacyl-CoA dehydrogenase
LGI35_RS23485	COG1309	transcriptional regulator
LGI35_RS23490	COG1522	sequence-specific DNA binding
LGI35_RS23510	COG0746	molybdenum cofactor guanylyltransferase activity
LGI35_RS23525	COG0604	alcohol dehydrogenase
LGI35_RS23540	COG0515	serine threonine protein kinase
LGI35_RS23545	COG0515	serine threonine protein kinase
LGI35_RS23570	COG0022	dehydrogenase e1 component
LGI35_RS23575	COG0508	dehydrogenase complex catalyzes the overall conversion of
LGI35_RS23620	COG0662	Cupin 2, conserved barrel domain protein
LGI35_RS23635	COG3903	Transcriptional regulator
LGI35_RS23635	COG3629	intracellular signal transduction
LGI35_RS23640	COG1362	aminopeptidase activity
LGI35_RS23645	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS23655	COG1741	Belongs to the pirin family
LGI35_RS23670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LGI35_RS23685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LGI35_RS23705	COG0583	DNA-binding transcription factor activity
LGI35_RS23715	COG1289	transmembrane transporter activity
LGI35_RS23740	COG1414	Transcriptional regulator
LGI35_RS23745	COG1475	DNA binding
LGI35_RS23750	COG1192	Involved in chromosome partitioning
LGI35_RS23760	COG0154	amidase activity
LGI35_RS23765	COG0477	Major facilitator Superfamily
LGI35_RS23770	COG1228	amidohydrolase
LGI35_RS23775	COG0668	transmembrane transport
LGI35_RS23815	COG0583	DNA-binding transcription factor activity
LGI35_RS23860	COG1250	3-hydroxyacyl-CoA dehydrogenase
LGI35_RS23865	COG0667	Aldo Keto reductase
LGI35_RS23870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LGI35_RS23875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LGI35_RS23905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LGI35_RS23910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LGI35_RS23935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGI35_RS23940	COG2326	polyphosphate kinase activity
LGI35_RS23960	COG0717	Belongs to the dCTP deaminase family
LGI35_RS23970	COG0477	Major facilitator Superfamily
LGI35_RS24015	COG2181	nitrate reductase activity
LGI35_RS24015	COG0247	lactate metabolic process
LGI35_RS24020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LGI35_RS24025	COG0443	Heat shock 70 kDa protein
LGI35_RS24030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LGI35_RS24035	COG0484	heat shock protein binding
LGI35_RS24040	COG0789	Transcriptional regulator
LGI35_RS24045	COG4213	ABC transporter substrate-binding protein
LGI35_RS24070	COG0542	response to heat
LGI35_RS24100	COG2255	four-way junction helicase activity
LGI35_RS24125	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LGI35_RS24140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LGI35_RS24145	COG0191	fructose-bisphosphate aldolase activity
LGI35_RS24150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LGI35_RS24160	COG3483	tryptophan 2,3-dioxygenase activity
LGI35_RS24165	COG3844	kynureninase activity
LGI35_RS24180	COG4585	Histidine kinase
LGI35_RS24185	COG2197	response regulator
LGI35_RS24195	COG1131	(ABC) transporter
LGI35_RS24200	COG3559	Exporter of polyketide antibiotics
LGI35_RS24210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LGI35_RS24220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LGI35_RS24235	COG0693	protein deglycase activity
LGI35_RS24245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LGI35_RS24250	COG1802	Transcriptional regulator
LGI35_RS24255	COG0463	Glycosyl transferase, family 2
LGI35_RS24270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LGI35_RS24275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LGI35_RS24295	COG1595	DNA-templated transcription, initiation
LGI35_RS24335	COG0586	Pfam SNARE associated Golgi protein
LGI35_RS24345	COG2268	Band 7 protein
LGI35_RS24350	COG1585	Membrane protein implicated in regulation of membrane protease activity
LGI35_RS24355	COG2770	Histidine kinase
LGI35_RS24355	COG2208	phosphoserine phosphatase activity
LGI35_RS24420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LGI35_RS24540	COG1408	metallophosphoesterase
LGI35_RS24550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LGI35_RS24560	COG0003	Pfam Anion-transporting ATPase
LGI35_RS24575	COG0251	oxidation-reduction process
LGI35_RS24590	COG1595	DNA-templated transcription, initiation
LGI35_RS24625	COG2267	carboxylic ester hydrolase activity
LGI35_RS24635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LGI35_RS24640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LGI35_RS24645	COG0659	secondary active sulfate transmembrane transporter activity
LGI35_RS24705	COG1111	helicase
LGI35_RS24705	COG1205	dead DEAH box helicase
LGI35_RS24710	COG1366	Belongs to the anti-sigma-factor antagonist family
LGI35_RS24715	COG2172	sigma factor antagonist activity
LGI35_RS24720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LGI35_RS24730	COG2890	protein-(glutamine-N5) methyltransferase activity
LGI35_RS24740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LGI35_RS24740	COG1754	DNA topoisomerase type I activity
LGI35_RS24745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LGI35_RS24750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LGI35_RS24840	COG1725	Transcriptional regulator
LGI35_RS24870	COG3903	Transcriptional regulator
LGI35_RS24870	COG3629	intracellular signal transduction
LGI35_RS24895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LGI35_RS24895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LGI35_RS24900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LGI35_RS24900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LGI35_RS24940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LGI35_RS24945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LGI35_RS24950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LGI35_RS24955	COG0254	rRNA binding
LGI35_RS24960	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS24995	COG2318	DinB family
LGI35_RS25015	COG0076	glutamate decarboxylase activity
LGI35_RS25025	COG0789	Transcriptional regulator
LGI35_RS25030	COG0393	Putative heavy-metal-binding
LGI35_RS25045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LGI35_RS25050	COG2027	D-alanyl-D-alanine carboxypeptidase
LGI35_RS25060	COG0037	tRNA processing
LGI35_RS25075	COG0302	gtp cyclohydrolase
LGI35_RS25090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LGI35_RS25105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LGI35_RS25105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LGI35_RS25120	COG1174	glycine betaine transport
LGI35_RS25125	COG1174	glycine betaine transport
LGI35_RS25150	COG0649	NAD binding
LGI35_RS25165	COG2197	response regulator
LGI35_RS25195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LGI35_RS25205	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LGI35_RS25230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LGI35_RS25255	COG0739	heme binding
LGI35_RS25275	COG0346	lactoylglutathione lyase activity
LGI35_RS25280	COG2205	protein histidine kinase activity
LGI35_RS25285	COG0745	RESPONSE REGULATOR receiver
LGI35_RS25295	COG1595	DNA-templated transcription, initiation
LGI35_RS25305	COG4585	Histidine kinase
LGI35_RS25310	COG2197	response regulator
LGI35_RS25315	COG0671	phosphoesterase, PA-phosphatase related
LGI35_RS25325	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LGI35_RS25345	COG0248	Ppx GppA phosphatase
LGI35_RS25350	COG1082	Xylose isomerase domain protein TIM barrel
LGI35_RS25360	COG0129	dihydroxy-acid dehydratase activity
LGI35_RS25370	COG4991	sh3 domain protein
LGI35_RS25400	COG0842	Transport permease protein
LGI35_RS25400	COG1129	ABC transporter
LGI35_RS25410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LGI35_RS25415	COG1335	isochorismatase
LGI35_RS25425	COG0180	Tryptophanyl-tRNA synthetase
LGI35_RS25445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LGI35_RS25460	COG0123	including yeast histone deacetylase and acetoin utilization protein
LGI35_RS25510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LGI35_RS25515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LGI35_RS25520	COG0181	hydroxymethylbilane synthase activity
LGI35_RS25525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LGI35_RS25525	COG1648	precorrin-2 dehydrogenase activity
LGI35_RS25530	COG0113	porphobilinogen synthase activity
LGI35_RS25545	COG0018	arginyl-trna synthetase
LGI35_RS25550	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LGI35_RS25570	COG1690	Belongs to the RtcB family
LGI35_RS25585	COG1742	UPF0060 membrane protein
LGI35_RS25615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS25620	COG0431	NADPH-dependent FMN reductase
LGI35_RS25635	COG0745	RESPONSE REGULATOR receiver
LGI35_RS25640	COG2205	protein histidine kinase activity
LGI35_RS25650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LGI35_RS25655	COG0406	alpha-ribazole phosphatase activity
LGI35_RS25670	COG0785	Cytochrome C biogenesis protein
LGI35_RS25675	COG1333	cytochrome c biogenesis protein
LGI35_RS25680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LGI35_RS25705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LGI35_RS25710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LGI35_RS25715	COG0163	prenyltransferase activity
LGI35_RS25725	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LGI35_RS25745	COG1309	transcriptional regulator
LGI35_RS25760	COG0183	Belongs to the thiolase family
LGI35_RS25790	COG1396	sequence-specific DNA binding
LGI35_RS25795	COG1278	Cold shock
LGI35_RS25800	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LGI35_RS25820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LGI35_RS25830	COG2226	methyltransferase
LGI35_RS25870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS25875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS25880	COG0649	NAD binding
LGI35_RS25890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LGI35_RS25895	COG1034	ATP synthesis coupled electron transport
LGI35_RS25900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LGI35_RS25905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS25915	COG0713	ATP synthesis coupled electron transport
LGI35_RS25920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LGI35_RS25930	COG1007	ATP synthesis coupled electron transport
LGI35_RS25935	COG0514	ATP-dependent DNA helicase (RecQ)
LGI35_RS25950	COG0492	ferredoxin-NADP+ reductase activity
LGI35_RS25955	COG0561	phosphatase activity
LGI35_RS25965	COG3104	oligopeptide transport
LGI35_RS25970	COG0142	geranyltranstransferase activity
LGI35_RS25990	COG0655	NAD(P)H dehydrogenase (quinone) activity
LGI35_RS25995	COG1733	regulation of RNA biosynthetic process
LGI35_RS26010	COG0702	epimerase
LGI35_RS26015	COG1733	regulation of RNA biosynthetic process
LGI35_RS26020	COG1013	pyruvate-flavodoxin oxidoreductase activity
LGI35_RS26025	COG0674	pyruvate-flavodoxin oxidoreductase activity
LGI35_RS26025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LGI35_RS26045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS26050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS26055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS26060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LGI35_RS26065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS26070	COG0839	Belongs to the complex I subunit 6 family
LGI35_RS26075	COG0713	ATP synthesis coupled electron transport
LGI35_RS26080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LGI35_RS26085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LGI35_RS26090	COG1007	ATP synthesis coupled electron transport
LGI35_RS26095	COG1970	mechanosensitive ion channel activity
LGI35_RS26100	COG0501	Belongs to the peptidase M48B family
LGI35_RS26105	COG3304	Inner membrane component domain
LGI35_RS26110	COG0542	response to heat
LGI35_RS26115	COG2815	serine threonine protein kinase
LGI35_RS26115	COG0515	serine threonine protein kinase
LGI35_RS26135	COG0443	Heat shock 70 kDa protein
LGI35_RS26150	COG1666	GTP binding
LGI35_RS26175	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LGI35_RS26195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LGI35_RS26205	COG0702	epimerase
LGI35_RS26230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LGI35_RS26235	COG2030	dehydratase
LGI35_RS26250	COG0477	Major facilitator Superfamily
LGI35_RS26260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LGI35_RS26265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LGI35_RS26280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LGI35_RS26285	COG0436	Aminotransferase
LGI35_RS26295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LGI35_RS26300	COG0250	Participates in transcription elongation, termination and antitermination
LGI35_RS26310	COG0081	regulation of translation
LGI35_RS26325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LGI35_RS26330	COG0222	ribosome binding
LGI35_RS26335	COG0085	RNA polymerase activity
LGI35_RS26340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LGI35_RS26375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LGI35_RS26380	COG0049	tRNA binding
LGI35_RS26385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LGI35_RS26405	COG0051	transcription antitermination factor activity, RNA binding
LGI35_RS26410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LGI35_RS26415	COG0088	Forms part of the polypeptide exit tunnel
LGI35_RS26420	COG0089	rRNA binding
LGI35_RS26425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LGI35_RS26430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LGI35_RS26435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LGI35_RS26440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LGI35_RS26445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LGI35_RS26450	COG0255	Belongs to the universal ribosomal protein uL29 family
LGI35_RS26455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LGI35_RS26460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LGI35_RS26465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LGI35_RS26470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LGI35_RS26475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LGI35_RS26480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LGI35_RS26485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LGI35_RS26490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LGI35_RS26495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LGI35_RS26500	COG1841	ribosomal large subunit assembly
LGI35_RS26505	COG0200	Binds to the 23S rRNA
LGI35_RS26515	COG0563	adenylate kinase activity
LGI35_RS26525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LGI35_RS26530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LGI35_RS26535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LGI35_RS26540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LGI35_RS26545	COG0202	RNA polymerase activity
LGI35_RS26550	COG0203	ribosomal protein L17
LGI35_RS26555	COG0101	tRNA pseudouridine synthase activity
LGI35_RS26565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LGI35_RS26570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LGI35_RS26575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LGI35_RS26585	COG1072	(Pantothenic acid kinase))
LGI35_RS26595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LGI35_RS26600	COG0736	holo-[acyl-carrier-protein] synthase activity
LGI35_RS26610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LGI35_RS26620	COG0802	atpase or kinase
LGI35_RS26640	COG0456	acetyltransferase
LGI35_RS26645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LGI35_RS26655	COG1316	TRANSCRIPTIONal
LGI35_RS26670	COG4941	Belongs to the sigma-70 factor family
LGI35_RS26680	COG0823	Involved in the tonB-independent uptake of proteins
LGI35_RS26690	COG0726	polysaccharide deacetylase
LGI35_RS26695	COG0726	polysaccharide deacetylase
LGI35_RS26700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LGI35_RS26705	COG0459	protein refolding
LGI35_RS26715	COG4221	oxidoreductase activity
LGI35_RS26725	COG0583	DNA-binding transcription factor activity
LGI35_RS26740	COG1595	DNA-templated transcription, initiation
LGI35_RS26750	COG0516	GMP reductase activity
LGI35_RS26760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LGI35_RS26780	COG0515	serine threonine protein kinase
LGI35_RS26785	COG0515	serine threonine protein kinase
LGI35_RS26795	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS26820	COG0519	Catalyzes the synthesis of GMP from XMP
LGI35_RS26820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LGI35_RS26860	COG2197	response regulator
LGI35_RS26905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS26920	COG0714	Associated with various cellular activities
LGI35_RS26925	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LGI35_RS26930	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LGI35_RS26945	COG0045	succinate-CoA ligase (ADP-forming) activity
LGI35_RS26975	COG0138	bifunctional purine biosynthesis protein purh
LGI35_RS26985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LGI35_RS27000	COG0039	L-malate dehydrogenase activity
LGI35_RS27005	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS27015	COG0517	IMP dehydrogenase activity
LGI35_RS27015	COG4175	Glycine betaine
LGI35_RS27020	COG4176	ABC-type proline glycine betaine transport system permease component
LGI35_RS27030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LGI35_RS27035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LGI35_RS27040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS27050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LGI35_RS27055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LGI35_RS27075	COG0180	Tryptophanyl-tRNA synthetase
LGI35_RS27115	COG1686	Belongs to the peptidase S11 family
LGI35_RS27125	COG1408	metallophosphoesterase
LGI35_RS27135	COG2205	protein histidine kinase activity
LGI35_RS27140	COG0745	RESPONSE REGULATOR receiver
LGI35_RS27150	COG2409	Drug exporters of the RND superfamily
LGI35_RS27155	COG2814	Major facilitator Superfamily
LGI35_RS27165	COG1686	Belongs to the peptidase S11 family
LGI35_RS27170	COG1309	transcriptional regulator
LGI35_RS27205	COG1053	succinate dehydrogenase
LGI35_RS27215	COG2009	succinate dehydrogenase
LGI35_RS27225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LGI35_RS27270	COG2318	DinB family
LGI35_RS27315	COG1595	DNA-templated transcription, initiation
LGI35_RS27325	COG1595	DNA-templated transcription, initiation
LGI35_RS27340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS27340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS27355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LGI35_RS27365	COG1216	Glycosyl transferase, family 2
LGI35_RS27380	COG2089	acid synthase
LGI35_RS27395	COG1473	amidohydrolase
LGI35_RS27395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LGI35_RS27400	COG1744	ABC transporter substrate-binding protein PnrA-like
LGI35_RS27405	COG3845	ABC transporter
LGI35_RS27410	COG4603	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS27415	COG1079	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS27445	COG2814	Major facilitator Superfamily
LGI35_RS27450	COG0583	DNA-binding transcription factor activity
LGI35_RS27460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LGI35_RS27485	COG2205	protein histidine kinase activity
LGI35_RS27490	COG0745	RESPONSE REGULATOR receiver
LGI35_RS27495	COG1595	DNA-templated transcription, initiation
LGI35_RS27510	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS27515	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS27520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LGI35_RS27530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LGI35_RS27560	COG4770	biotin carboxylase activity
LGI35_RS27570	COG0424	maF-like protein
LGI35_RS27580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LGI35_RS27590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LGI35_RS27595	COG1024	Enoyl-CoA hydratase
LGI35_RS27620	COG1376	ErfK ybiS ycfS ynhG family protein
LGI35_RS27630	COG1136	(ABC) transporter
LGI35_RS27635	COG1404	Belongs to the peptidase S8 family
LGI35_RS27650	COG1064	alcohol dehydrogenase
LGI35_RS27675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LGI35_RS27700	COG2255	four-way junction helicase activity
LGI35_RS27705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LGI35_RS27720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LGI35_RS27730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LGI35_RS27745	COG1331	Highly conserved protein containing a thioredoxin domain
LGI35_RS27750	COG1309	transcriptional regulator
LGI35_RS27755	COG0477	Major facilitator Superfamily
LGI35_RS27765	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LGI35_RS27790	COG0436	Aminotransferase
LGI35_RS27795	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LGI35_RS27810	COG1414	Transcriptional regulator
LGI35_RS27815	COG0251	oxidation-reduction process
LGI35_RS27820	COG2610	gluconate transmembrane transporter activity
LGI35_RS27905	COG2894	cell division
LGI35_RS27960	COG2885	chlorophyll binding
LGI35_RS27965	COG2124	cytochrome p450
LGI35_RS27970	COG2318	DinB family
LGI35_RS27990	COG0667	Aldo Keto reductase
LGI35_RS27995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LGI35_RS28000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LGI35_RS28015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LGI35_RS28020	COG0450	alkyl hydroperoxide reductase
LGI35_RS28035	COG1136	(ABC) transporter
LGI35_RS28055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LGI35_RS28065	COG2226	methyltransferase
LGI35_RS28075	COG0114	fumarate hydratase activity
LGI35_RS28080	COG2755	lipolytic protein G-D-S-L family
LGI35_RS28085	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LGI35_RS28085	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LGI35_RS28110	COG0778	Nitroreductase
LGI35_RS28115	COG1722	exodeoxyribonuclease VII activity
LGI35_RS28120	COG1570	exodeoxyribonuclease VII activity
LGI35_RS28125	COG1113	amino acid transport
LGI35_RS28130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LGI35_RS28145	COG0012	GTP binding
LGI35_RS28185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LGI35_RS28225	COG1842	Phage shock protein A
LGI35_RS28240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LGI35_RS28245	COG1053	succinate dehydrogenase
LGI35_RS28265	COG1217	gtp-binding protein TYPA
LGI35_RS28270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS28275	COG4166	transmembrane transport
LGI35_RS28285	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS28290	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS28305	COG0601	transmembrane transport
LGI35_RS28310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS28320	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS28335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LGI35_RS28350	COG1131	(ABC) transporter
LGI35_RS28360	COG4585	Histidine kinase
LGI35_RS28365	COG2197	response regulator
LGI35_RS28400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LGI35_RS28420	COG0519	Catalyzes the synthesis of GMP from XMP
LGI35_RS28425	COG1024	Enoyl-CoA hydratase
LGI35_RS28440	COG1595	DNA-templated transcription, initiation
LGI35_RS28450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LGI35_RS28455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LGI35_RS28490	COG0598	Magnesium transport protein CorA
LGI35_RS28500	COG2814	Major facilitator Superfamily
LGI35_RS28515	COG2095	MarC family integral membrane protein
LGI35_RS28525	COG1432	Conserved Protein
LGI35_RS28535	COG0513	Belongs to the DEAD box helicase family
LGI35_RS28575	COG0747	negative chemotaxis
LGI35_RS28580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS28585	COG0601	transmembrane transport
LGI35_RS28590	COG4172	Belongs to the ABC transporter superfamily
LGI35_RS28650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LGI35_RS28690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LGI35_RS28745	COG3480	Lon protease (S16) C-terminal proteolytic domain
LGI35_RS28755	COG1615	UPF0182 protein
LGI35_RS28795	COG0753	catalase activity
LGI35_RS28805	COG0483	inositol monophosphate 1-phosphatase activity
LGI35_RS28820	COG1162	GTPase activity
LGI35_RS28825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LGI35_RS28835	COG2135	peptidase activity
LGI35_RS28845	COG1595	DNA-templated transcription, initiation
LGI35_RS28850	COG5662	AntiSigma factor
LGI35_RS28855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LGI35_RS28855	COG2199	diguanylate cyclase activity
LGI35_RS28870	COG0242	peptide deformylase activity
LGI35_RS28880	COG2124	cytochrome p450
LGI35_RS28895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LGI35_RS28920	COG2188	Transcriptional regulator
LGI35_RS28925	COG2182	Extracellular solute-binding protein
LGI35_RS28930	COG1175	transmembrane transport
LGI35_RS28935	COG0395	ABC-type sugar transport system, permease component
LGI35_RS28940	COG1472	Belongs to the glycosyl hydrolase 3 family
LGI35_RS28945	COG0363	glucosamine-6-phosphate deaminase activity
LGI35_RS28950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LGI35_RS28955	COG1309	transcriptional regulator
LGI35_RS28970	COG1597	lipid kinase activity
LGI35_RS28985	COG2172	sigma factor antagonist activity
LGI35_RS29015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LGI35_RS29020	COG0142	geranyltranstransferase activity
LGI35_RS29025	COG0456	acetyltransferase
LGI35_RS29045	COG4941	Belongs to the sigma-70 factor family
LGI35_RS29085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LGI35_RS29115	COG4106	trans-aconitate 2-methyltransferase activity
LGI35_RS29120	COG1126	abc transporter atp-binding protein
LGI35_RS29135	COG0281	malic enzyme
LGI35_RS29140	COG0604	alcohol dehydrogenase
LGI35_RS29165	COG0567	Dehydrogenase, E1 component
LGI35_RS29165	COG0508	dehydrogenase complex catalyzes the overall conversion of
LGI35_RS29170	COG2205	protein histidine kinase activity
LGI35_RS29175	COG0745	RESPONSE REGULATOR receiver
LGI35_RS29190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LGI35_RS29250	COG0791	NLP P60 protein
LGI35_RS29250	COG3883	PFAM NLP P60 protein
LGI35_RS29285	COG0768	penicillin binding
LGI35_RS29295	COG2205	protein histidine kinase activity
LGI35_RS29325	COG1793	dna ligase
LGI35_RS29325	COG3285	dna ligase
LGI35_RS29330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LGI35_RS29340	COG2226	methyltransferase
LGI35_RS29375	COG0018	arginyl-trna synthetase
LGI35_RS29375	COG0018	arginyl-trna synthetase
LGI35_RS29380	COG0019	diaminopimelate decarboxylase activity
LGI35_RS29385	COG0460	homoserine dehydrogenase
LGI35_RS29390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LGI35_RS29395	COG0083	homoserine kinase activity
LGI35_RS29415	COG0254	rRNA binding
LGI35_RS29420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LGI35_RS29425	COG2890	protein-(glutamine-N5) methyltransferase activity
LGI35_RS29435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LGI35_RS29440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LGI35_RS29445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LGI35_RS29460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LGI35_RS29465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LGI35_RS29470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LGI35_RS29475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LGI35_RS29480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LGI35_RS29485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LGI35_RS29490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LGI35_RS29505	COG2197	response regulator
LGI35_RS29510	COG4585	Histidine kinase
LGI35_RS29535	COG1250	3-hydroxyacyl-CoA dehydrogenase
LGI35_RS29550	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LGI35_RS29585	COG1131	(ABC) transporter
LGI35_RS29605	COG0183	Belongs to the thiolase family
LGI35_RS29625	COG0745	RESPONSE REGULATOR receiver
LGI35_RS29675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS29675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS29715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LGI35_RS29720	COG0857	belongs to the CobB CobQ family
LGI35_RS29720	COG0280	phosphate acetyltransferase
LGI35_RS29725	COG0205	6-phosphofructokinase activity
LGI35_RS29735	COG1802	Transcriptional regulator
LGI35_RS29755	COG0395	ABC-type sugar transport system, permease component
LGI35_RS29760	COG1175	transmembrane transport
LGI35_RS29770	COG4565	transcriptional regulatory protein
LGI35_RS29775	COG3290	protein histidine kinase activity
LGI35_RS29780	COG1301	dicarboxylic acid transport
LGI35_RS29790	COG0477	Major facilitator Superfamily
LGI35_RS29810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LGI35_RS29820	COG0366	Alpha amylase catalytic
LGI35_RS29825	COG0366	Alpha amylase catalytic
LGI35_RS29835	COG0515	serine threonine protein kinase
LGI35_RS29835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LGI35_RS29840	COG0515	serine threonine protein kinase
LGI35_RS29840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LGI35_RS29845	COG0058	SHG alpha-glucan phosphorylase activity
LGI35_RS29850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LGI35_RS29865	COG1132	(ABC) transporter
LGI35_RS29870	COG1132	(ABC) transporter
LGI35_RS29875	COG1131	(ABC) transporter
LGI35_RS29885	COG4585	Histidine kinase
LGI35_RS29890	COG2197	response regulator
LGI35_RS29945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LGI35_RS29950	COG2186	Transcriptional regulator
LGI35_RS29970	COG1760	l-serine dehydratase
LGI35_RS29975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LGI35_RS29980	COG0509	glycine decarboxylation via glycine cleavage system
LGI35_RS29985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LGI35_RS30005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS30010	COG4166	transmembrane transport
LGI35_RS30015	COG0601	transmembrane transport
LGI35_RS30020	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS30025	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS30030	COG0308	aminopeptidase N
LGI35_RS30035	COG2860	membrane
LGI35_RS30045	COG2378	regulation of single-species biofilm formation
LGI35_RS30080	COG0482	sulfurtransferase activity
LGI35_RS30100	COG4221	oxidoreductase activity
LGI35_RS30110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LGI35_RS30120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LGI35_RS30125	COG0154	amidase activity
LGI35_RS30135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LGI35_RS30140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LGI35_RS30145	COG2409	Drug exporters of the RND superfamily
LGI35_RS30175	COG0842	Transport permease protein
LGI35_RS30175	COG1716	ATPase activity
LGI35_RS30175	COG1131	(ABC) transporter
LGI35_RS30190	COG2197	response regulator
LGI35_RS30205	COG0667	Aldo Keto reductase
LGI35_RS30225	COG0440	acetolactate synthase activity
LGI35_RS30230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LGI35_RS30235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LGI35_RS30240	COG0477	Major facilitator Superfamily
LGI35_RS30250	COG2508	Transcriptional regulator
LGI35_RS30255	COG0506	proline dehydrogenase activity
LGI35_RS30260	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS30300	COG0473	3-isopropylmalate dehydrogenase activity
LGI35_RS30305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LGI35_RS30315	COG0832	Belongs to the urease beta subunit family
LGI35_RS30315	COG0831	urea catabolic process
LGI35_RS30320	COG0804	urea catabolic process
LGI35_RS30325	COG2957	Belongs to the agmatine deiminase family
LGI35_RS30335	COG0477	Major facilitator Superfamily
LGI35_RS30340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LGI35_RS30350	COG1472	Belongs to the glycosyl hydrolase 3 family
LGI35_RS30365	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LGI35_RS30375	COG0531	amino acid
LGI35_RS30390	COG0366	Alpha amylase catalytic
LGI35_RS30390	COG1470	cell adhesion involved in biofilm formation
LGI35_RS30400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LGI35_RS30420	COG2018	Roadblock/LC7 domain
LGI35_RS30440	COG2018	Roadblock/LC7 domain
LGI35_RS30445	COG5002	protein histidine kinase activity
LGI35_RS30455	COG0179	Fumarylacetoacetate (FAA) hydrolase
LGI35_RS30460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LGI35_RS30495	COG1414	Transcriptional regulator
LGI35_RS30500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LGI35_RS30505	COG0066	3-isopropylmalate dehydratase activity
LGI35_RS30515	COG0776	regulation of translation
LGI35_RS30525	COG1920	GTP binding
LGI35_RS30535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LGI35_RS30540	COG1181	Belongs to the D-alanine--D-alanine ligase family
LGI35_RS30570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LGI35_RS30575	COG1461	Dihydroxyacetone kinase
LGI35_RS30580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LGI35_RS30585	COG0742	ribosomal rna small subunit methyltransferase
LGI35_RS30590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LGI35_RS30605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LGI35_RS30610	COG0571	ribonuclease III activity
LGI35_RS30615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LGI35_RS30620	COG1733	regulation of RNA biosynthetic process
LGI35_RS30625	COG2340	Cysteine-rich secretory protein family
LGI35_RS30630	COG1254	Belongs to the acylphosphatase family
LGI35_RS30640	COG1196	nuclear chromosome segregation
LGI35_RS30645	COG0477	Major facilitator Superfamily
LGI35_RS30685	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LGI35_RS30695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LGI35_RS30700	COG3457	Alanine racemase
LGI35_RS30705	COG0626	cystathionine gamma-synthase activity
LGI35_RS30710	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LGI35_RS30730	COG2188	Transcriptional regulator
LGI35_RS30735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LGI35_RS30745	COG0442	prolyl-tRNA aminoacylation
LGI35_RS30755	COG0228	four-way junction DNA binding
LGI35_RS30760	COG1837	Belongs to the UPF0109 family
LGI35_RS30765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LGI35_RS30770	COG0336	Belongs to the RNA methyltransferase TrmD family
LGI35_RS30775	COG0335	large ribosomal subunit rRNA binding
LGI35_RS30780	COG0681	Belongs to the peptidase S26 family
LGI35_RS30785	COG0681	Belongs to the peptidase S26 family
LGI35_RS30790	COG0681	Belongs to the peptidase S26 family
LGI35_RS30795	COG0681	Belongs to the peptidase S26 family
LGI35_RS30800	COG1051	belongs to the nudix hydrolase family
LGI35_RS30810	COG0792	nuclease activity
LGI35_RS30825	COG1191	sigma factor activity
LGI35_RS30840	COG0052	Belongs to the universal ribosomal protein uS2 family
LGI35_RS30845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LGI35_RS30850	COG0528	UMP kinase activity
LGI35_RS30855	COG0233	cytoplasmic translational termination
LGI35_RS30860	COG0575	Belongs to the CDS family
LGI35_RS30880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LGI35_RS30890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LGI35_RS30905	COG3842	ATPase activity
LGI35_RS30930	COG4181	ATPase activity
LGI35_RS30935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LGI35_RS30945	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS30960	COG0584	glycerophosphoryl diester phosphodiesterase
LGI35_RS30965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LGI35_RS30980	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS30990	COG3842	ATPase activity
LGI35_RS30995	COG1176	ABC-type spermidine putrescine transport system, permease component I
LGI35_RS31000	COG1177	transmembrane transport
LGI35_RS31005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LGI35_RS31030	COG2508	Transcriptional regulator
LGI35_RS31035	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS31050	COG0653	protein targeting
LGI35_RS31055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LGI35_RS31060	COG0750	zinc metalloprotease
LGI35_RS31065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LGI35_RS31080	COG0747	negative chemotaxis
LGI35_RS31085	COG0601	transmembrane transport
LGI35_RS31090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS31095	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS31110	COG0442	prolyl-tRNA aminoacylation
LGI35_RS31130	COG0779	Required for maturation of 30S ribosomal subunits
LGI35_RS31145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LGI35_RS31155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LGI35_RS31160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LGI35_RS31175	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS31185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS31190	COG0601	transmembrane transport
LGI35_RS31195	COG0747	negative chemotaxis
LGI35_RS31200	COG0455	bacterial-type flagellum organization
LGI35_RS31220	COG1404	Belongs to the peptidase S8 family
LGI35_RS31320	COG1674	ftsk spoiiie
LGI35_RS31330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LGI35_RS31335	COG1185	polyribonucleotide nucleotidyltransferase activity
LGI35_RS31340	COG0612	Peptidase, M16
LGI35_RS31345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LGI35_RS31365	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LGI35_RS31370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS31375	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LGI35_RS31405	COG2770	Histidine kinase
LGI35_RS31405	COG2208	phosphoserine phosphatase activity
LGI35_RS31410	COG2205	protein histidine kinase activity
LGI35_RS31410	COG4999	Histidine kinase
LGI35_RS31410	COG3437	response regulator, receiver
LGI35_RS31410	COG3850	Histidine kinase
LGI35_RS31420	COG1674	ftsk spoiiie
LGI35_RS31425	COG1426	Protein conserved in bacteria
LGI35_RS31430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LGI35_RS31440	COG1546	Belongs to the CinA family
LGI35_RS31440	COG1058	Belongs to the CinA family
LGI35_RS31445	COG1396	sequence-specific DNA binding
LGI35_RS31455	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS31460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LGI35_RS31465	COG1201	RNA secondary structure unwinding
LGI35_RS31470	COG1917	Cupin 2, conserved barrel domain protein
LGI35_RS31470	COG2207	Transcriptional regulator
LGI35_RS31510	COG0628	permease
LGI35_RS31535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LGI35_RS31555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LGI35_RS31570	COG0765	amino acid transport
LGI35_RS31575	COG0765	amino acid transport
LGI35_RS31580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LGI35_RS31585	COG1126	abc transporter atp-binding protein
LGI35_RS31590	COG0745	RESPONSE REGULATOR receiver
LGI35_RS31595	COG2205	protein histidine kinase activity
LGI35_RS31635	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS31640	COG2124	cytochrome p450
LGI35_RS31665	COG0477	Major facilitator Superfamily
LGI35_RS31710	COG2130	NADP-dependent
LGI35_RS31750	COG2318	DinB family
LGI35_RS31760	COG0596	Alpha beta hydrolase
LGI35_RS31770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS31775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LGI35_RS31780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LGI35_RS31810	COG0604	alcohol dehydrogenase
LGI35_RS31810	COG3321	synthase
LGI35_RS31820	COG2197	response regulator
LGI35_RS31845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LGI35_RS31855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LGI35_RS31870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LGI35_RS31870	COG0674	pyruvate-flavodoxin oxidoreductase activity
LGI35_RS31875	COG1013	pyruvate-flavodoxin oxidoreductase activity
LGI35_RS31880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LGI35_RS31900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LGI35_RS31910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LGI35_RS31915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LGI35_RS31925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LGI35_RS31965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LGI35_RS31970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LGI35_RS31975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LGI35_RS32015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LGI35_RS32060	COG2186	Transcriptional regulator
LGI35_RS32065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LGI35_RS32080	COG0187	DNA topoisomerase II activity
LGI35_RS32090	COG4585	Histidine kinase
LGI35_RS32095	COG2197	response regulator
LGI35_RS32105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LGI35_RS32120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LGI35_RS32125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LGI35_RS32130	COG4565	transcriptional regulatory protein
LGI35_RS32135	COG3290	protein histidine kinase activity
LGI35_RS32150	COG0372	Belongs to the citrate synthase family
LGI35_RS32170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LGI35_RS32175	COG0612	Peptidase, M16
LGI35_RS32190	COG1802	Transcriptional regulator
LGI35_RS32195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LGI35_RS32215	COG1435	thymidine kinase activity
LGI35_RS32250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LGI35_RS32265	COG0745	RESPONSE REGULATOR receiver
LGI35_RS32270	COG2205	protein histidine kinase activity
LGI35_RS32295	COG0756	dUTP diphosphatase activity
LGI35_RS32320	COG1136	(ABC) transporter
LGI35_RS32320	COG4591	ABC-type transport system involved in lipoprotein release permease component
LGI35_RS32350	COG0569	domain protein
LGI35_RS32355	COG3594	Acyltransferase
LGI35_RS32360	COG0640	Transcriptional regulator
LGI35_RS32370	COG0531	amino acid
LGI35_RS32375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LGI35_RS32440	COG2723	6-phospho-beta-galactosidase activity
LGI35_RS32445	COG1309	transcriptional regulator
LGI35_RS32450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LGI35_RS32455	COG1472	Belongs to the glycosyl hydrolase 3 family
LGI35_RS32460	COG2755	lipolytic protein G-D-S-L family
LGI35_RS32475	COG4172	Belongs to the ABC transporter superfamily
LGI35_RS32490	COG1278	Cold shock
LGI35_RS32495	COG0513	Belongs to the DEAD box helicase family
LGI35_RS32530	COG2197	response regulator
LGI35_RS32550	COG2132	Multicopper oxidase
LGI35_RS32630	COG1136	(ABC) transporter
LGI35_RS32640	COG1799	cell septum assembly
LGI35_RS32675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LGI35_RS32680	COG2235	arginine
LGI35_RS32685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LGI35_RS32695	COG1024	Enoyl-CoA hydratase
LGI35_RS32725	COG1064	alcohol dehydrogenase
LGI35_RS32730	COG1414	Transcriptional regulator
LGI35_RS32745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LGI35_RS32750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LGI35_RS32770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LGI35_RS32785	COG1653	transport
LGI35_RS32790	COG1175	transmembrane transport
LGI35_RS32795	COG0395	ABC-type sugar transport system, permease component
LGI35_RS32800	COG1940	carbohydrate kinase activity
LGI35_RS32805	COG4213	ABC transporter substrate-binding protein
LGI35_RS32815	COG4214	carbohydrate transport
LGI35_RS32820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LGI35_RS32825	COG0531	amino acid
LGI35_RS32840	COG0438	transferase activity, transferring glycosyl groups
LGI35_RS32845	COG1215	transferase activity, transferring glycosyl groups
LGI35_RS32845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS32855	COG1215	transferase activity, transferring glycosyl groups
LGI35_RS32855	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS32865	COG1250	3-hydroxyacyl-CoA dehydrogenase
LGI35_RS32865	COG1024	Enoyl-CoA hydratase
LGI35_RS32870	COG0183	Belongs to the thiolase family
LGI35_RS32880	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LGI35_RS32895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LGI35_RS32905	COG0446	pyridine nucleotide-disulphide oxidoreductase
LGI35_RS32915	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LGI35_RS32920	COG3253	May function as heme-dependent peroxidase
LGI35_RS32940	COG3220	belongs to the UPF0276 family
LGI35_RS32970	COG1222	aaa ATPase
LGI35_RS33070	COG2326	polyphosphate kinase activity
LGI35_RS33095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LGI35_RS33100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LGI35_RS33120	COG1357	PFAM Pentapeptide repeats (8 copies)
LGI35_RS33145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LGI35_RS33150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LGI35_RS33160	COG3173	Aminoglycoside phosphotransferase
LGI35_RS33255	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS33260	COG1252	NADH dehydrogenase
LGI35_RS33265	COG1271	oxidase subunit
LGI35_RS33270	COG1294	oxidase, subunit
LGI35_RS33285	COG3387	PFAM Glycoside hydrolase 15-related
LGI35_RS33290	COG2017	converts alpha-aldose to the beta-anomer
LGI35_RS33310	COG2409	Drug exporters of the RND superfamily
LGI35_RS33335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LGI35_RS33350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LGI35_RS33355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LGI35_RS33375	COG0529	Catalyzes the synthesis of activated sulfate
LGI35_RS33380	COG0175	sulfate reduction
LGI35_RS33415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LGI35_RS33420	COG4209	transmembrane transport
LGI35_RS33425	COG0395	ABC-type sugar transport system, permease component
LGI35_RS33440	COG1349	DNA-binding transcription factor activity
LGI35_RS33460	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS33475	COG1522	sequence-specific DNA binding
LGI35_RS33480	COG2814	Major facilitator Superfamily
LGI35_RS33500	COG0583	DNA-binding transcription factor activity
LGI35_RS33505	COG2040	homocysteine
LGI35_RS33525	COG1940	carbohydrate kinase activity
LGI35_RS33580	COG1162	GTPase activity
LGI35_RS33590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LGI35_RS33625	COG1404	Belongs to the peptidase S8 family
LGI35_RS33635	COG0028	Belongs to the TPP enzyme family
LGI35_RS33655	COG1802	Transcriptional regulator
LGI35_RS33665	COG3835	regulator
LGI35_RS33680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LGI35_RS33685	COG2252	PERMEase
LGI35_RS33715	COG0726	polysaccharide deacetylase
LGI35_RS33730	COG0477	Major facilitator Superfamily
LGI35_RS33735	COG1309	transcriptional regulator
LGI35_RS33740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LGI35_RS33745	COG1082	Xylose isomerase domain protein TIM barrel
LGI35_RS33745	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LGI35_RS33755	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LGI35_RS33760	COG2080	2 iron, 2 sulfur cluster binding
LGI35_RS33760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LGI35_RS33770	COG1597	lipid kinase activity
LGI35_RS33785	COG0598	Magnesium transport protein CorA
LGI35_RS33795	COG2197	response regulator
LGI35_RS33800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LGI35_RS33805	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS33815	COG3960	tartronate-semialdehyde synthase activity
LGI35_RS33825	COG0753	catalase activity
LGI35_RS33830	COG2084	Dehydrogenase
LGI35_RS33835	COG3622	Belongs to the hyi family
LGI35_RS33855	COG2351	hydroxyisourate hydrolase activity
LGI35_RS33865	COG2233	PERMEase
LGI35_RS33875	COG2233	PERMEase
LGI35_RS33880	COG2233	PERMEase
LGI35_RS33885	COG2223	nitrite transmembrane transporter activity
LGI35_RS33890	COG2207	Transcriptional regulator
LGI35_RS33920	COG0588	phosphoglycerate mutase activity
LGI35_RS33925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LGI35_RS33955	COG0436	Aminotransferase
LGI35_RS33985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LGI35_RS34000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS34010	COG2197	response regulator
LGI35_RS34020	COG0577	efflux transmembrane transporter activity
LGI35_RS34030	COG1414	Transcriptional regulator
LGI35_RS34035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LGI35_RS34040	COG4266	Belongs to the allantoicase family
LGI35_RS34045	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS34070	COG2197	response regulator
LGI35_RS34075	COG1940	carbohydrate kinase activity
LGI35_RS34100	COG2309	aminopeptidase activity
LGI35_RS34110	COG0673	inositol 2-dehydrogenase activity
LGI35_RS34115	COG2188	Transcriptional regulator
LGI35_RS34130	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS34140	COG1940	carbohydrate kinase activity
LGI35_RS34150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LGI35_RS34155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LGI35_RS34160	COG1335	isochorismatase
LGI35_RS34180	COG1126	abc transporter atp-binding protein
LGI35_RS34185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGI35_RS34190	COG0765	amino acid transport
LGI35_RS34195	COG0765	amino acid transport
LGI35_RS34210	COG0405	Gamma-glutamyltransferase
LGI35_RS34240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LGI35_RS34255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LGI35_RS34260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS34265	COG1953	Uracil, thiamine, allantoin
LGI35_RS34285	COG2197	response regulator
LGI35_RS34290	COG3708	Transcriptional regulator
LGI35_RS34290	COG2207	Transcriptional regulator
LGI35_RS34305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS34315	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS34325	COG0483	inositol monophosphate 1-phosphatase activity
LGI35_RS34335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LGI35_RS34345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LGI35_RS34355	COG3548	integral membrane protein
LGI35_RS34370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LGI35_RS34380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LGI35_RS34395	COG1929	Belongs to the glycerate kinase type-1 family
LGI35_RS34415	COG1063	alcohol dehydrogenase
LGI35_RS34425	COG0688	phosphatidylethanolamine metabolic process
LGI35_RS34430	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS34445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS34445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LGI35_RS34450	COG0604	alcohol dehydrogenase
LGI35_RS34460	COG1250	3-hydroxyacyl-CoA dehydrogenase
LGI35_RS34475	COG0596	Alpha beta hydrolase
LGI35_RS34495	COG2172	sigma factor antagonist activity
LGI35_RS34495	COG1366	Belongs to the anti-sigma-factor antagonist family
LGI35_RS34495	COG2208	phosphoserine phosphatase activity
LGI35_RS34510	COG2261	transglycosylase associated protein
LGI35_RS34520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LGI35_RS34525	COG2362	D-Aminopeptidase
LGI35_RS34530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LGI35_RS34535	COG1506	peptidase
LGI35_RS34535	COG4946	Tricorn protease homolog
LGI35_RS34535	COG0823	Involved in the tonB-independent uptake of proteins
LGI35_RS34540	COG1619	proteins homologs of microcin C7 resistance protein MccF
LGI35_RS34560	COG0457	Tetratricopeptide repeat
LGI35_RS34565	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS34570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LGI35_RS34585	COG2226	methyltransferase
LGI35_RS34590	COG1597	lipid kinase activity
LGI35_RS34595	COG0488	(ABC) transporter
LGI35_RS34630	COG0531	amino acid
LGI35_RS34650	COG2154	pterin-4-alpha-carbinolamine dehydratase
LGI35_RS34680	COG2378	regulation of single-species biofilm formation
LGI35_RS34720	COG0583	DNA-binding transcription factor activity
LGI35_RS34745	COG1846	Transcriptional regulator
LGI35_RS34750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LGI35_RS34760	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LGI35_RS34765	COG3383	formate dehydrogenase (NAD+) activity
LGI35_RS34770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LGI35_RS34785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LGI35_RS34800	COG1940	carbohydrate kinase activity
LGI35_RS34805	COG1129	ABC transporter
LGI35_RS34810	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS34815	COG1879	ABC-type sugar transport system periplasmic component
LGI35_RS34820	COG0673	inositol 2-dehydrogenase activity
LGI35_RS34845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LGI35_RS34850	COG1082	Xylose isomerase domain protein TIM barrel
LGI35_RS34885	COG2223	nitrite transmembrane transporter activity
LGI35_RS34895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS34905	COG0045	succinate-CoA ligase (ADP-forming) activity
LGI35_RS34915	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS34945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LGI35_RS34950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LGI35_RS34955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LGI35_RS34975	COG1309	transcriptional regulator
LGI35_RS34980	COG1902	pentaerythritol trinitrate reductase activity
LGI35_RS34980	COG0446	pyridine nucleotide-disulphide oxidoreductase
LGI35_RS34985	COG2188	Transcriptional regulator
LGI35_RS34990	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS35005	COG0477	Major facilitator Superfamily
LGI35_RS35005	COG2814	Major facilitator Superfamily
LGI35_RS35010	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LGI35_RS35015	COG2301	Belongs to the HpcH HpaI aldolase family
LGI35_RS35020	COG0583	DNA-binding transcription factor activity
LGI35_RS35025	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS35040	COG0183	Belongs to the thiolase family
LGI35_RS35065	COG2807	transmembrane transport
LGI35_RS35105	COG2706	6-phosphogluconolactonase activity
LGI35_RS35110	COG0477	Major facilitator Superfamily
LGI35_RS35120	COG1486	melibiose metabolic process
LGI35_RS35125	COG0383	alpha-mannosidase activity
LGI35_RS35130	COG3511	phospholipase C
LGI35_RS35140	COG0477	Major facilitator Superfamily
LGI35_RS35170	COG1672	PFAM Archaeal ATPase
LGI35_RS35170	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LGI35_RS35175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LGI35_RS35180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LGI35_RS35185	COG3485	protocatechuate 3,4-dioxygenase
LGI35_RS35190	COG3485	protocatechuate 3,4-dioxygenase
LGI35_RS35210	COG1846	Transcriptional regulator
LGI35_RS35220	COG1793	dna ligase
LGI35_RS35270	COG1834	amidinotransferase
LGI35_RS35275	COG0488	(ABC) transporter
LGI35_RS35305	COG1515	deoxyribonuclease V activity
LGI35_RS35310	COG3268	Saccharopine dehydrogenase
LGI35_RS35320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS35325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS35330	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS35335	COG0183	Belongs to the thiolase family
LGI35_RS35340	COG1250	3-hydroxyacyl-CoA dehydrogenase
LGI35_RS35340	COG1024	Enoyl-CoA hydratase
LGI35_RS35345	COG0789	Transcriptional regulator
LGI35_RS35350	COG1113	amino acid transport
LGI35_RS35375	COG2936	dipeptidyl-peptidase activity
LGI35_RS35385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LGI35_RS35400	COG0488	(ABC) transporter
LGI35_RS35405	COG2183	response to ionizing radiation
LGI35_RS35415	COG4977	sequence-specific DNA binding
LGI35_RS35425	COG1024	Enoyl-CoA hydratase
LGI35_RS35435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LGI35_RS35445	COG1230	cation diffusion facilitator family transporter
LGI35_RS35485	COG1134	teichoic acid transport
LGI35_RS35490	COG1562	ergosterol biosynthetic process
LGI35_RS35500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LGI35_RS35510	COG1657	PFAM Prenyltransferase squalene oxidase
LGI35_RS35525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LGI35_RS35530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LGI35_RS35560	COG2755	lipolytic protein G-D-S-L family
LGI35_RS35570	COG0531	amino acid
LGI35_RS35590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LGI35_RS35600	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS35650	COG1609	Transcriptional regulator
LGI35_RS35660	COG4209	transmembrane transport
LGI35_RS35665	COG0395	ABC-type sugar transport system, permease component
LGI35_RS35685	COG1063	alcohol dehydrogenase
LGI35_RS35690	COG0156	8-amino-7-oxononanoate synthase activity
LGI35_RS35695	COG0583	DNA-binding transcription factor activity
LGI35_RS35705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LGI35_RS35715	COG1116	anion transmembrane transporter activity
LGI35_RS35735	COG3507	Belongs to the glycosyl hydrolase 43 family
LGI35_RS35750	COG3958	Transketolase
LGI35_RS35755	COG3959	Transketolase, thiamine diphosphate binding domain
LGI35_RS35770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LGI35_RS35780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LGI35_RS35785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LGI35_RS35840	COG2319	Wd-40 repeat
LGI35_RS35840	COG4249	Peptidase C14 caspase catalytic subunit p20
LGI35_RS35975	COG2255	four-way junction helicase activity
LGI35_RS36050	COG0741	lytic transglycosylase activity
LGI35_RS36050	COG0791	NLP P60 protein
LGI35_RS36130	COG0582	viral genome integration into host DNA
LGI35_RS36350	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS36375	COG2124	cytochrome p450
LGI35_RS36385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS36460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LGI35_RS36475	COG0798	PFAM Bile acid sodium symporter
LGI35_RS36485	COG0640	Transcriptional regulator
LGI35_RS36550	COG2197	response regulator
LGI35_RS36560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LGI35_RS36610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS36620	COG0583	DNA-binding transcription factor activity
LGI35_RS36665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LGI35_RS36845	COG1704	LemA family
LGI35_RS36855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LGI35_RS36860	COG0673	inositol 2-dehydrogenase activity
LGI35_RS36910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS36915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGI35_RS36920	COG1216	Glycosyl transferase, family 2
LGI35_RS37045	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS37050	COG1309	transcriptional regulator
LGI35_RS37060	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS37070	COG2175	clavaminate synthase activity
LGI35_RS37075	COG1113	amino acid transport
LGI35_RS37080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LGI35_RS37110	COG1609	Transcriptional regulator
LGI35_RS37115	COG2211	Major facilitator Superfamily
LGI35_RS37125	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LGI35_RS37140	COG1414	Transcriptional regulator
LGI35_RS37145	COG3964	amidohydrolase
LGI35_RS37180	COG0800	Aldolase
LGI35_RS37190	COG0006	proline dipeptidase activity
LGI35_RS37210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS37215	COG3938	Belongs to the proline racemase family
LGI35_RS37230	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS37240	COG0537	adenosine 5'-monophosphoramidase activity
LGI35_RS37270	COG1250	3-hydroxyacyl-CoA dehydrogenase
LGI35_RS37275	COG3246	L-lysine catabolic process to acetate
LGI35_RS37280	COG1309	transcriptional regulator
LGI35_RS37295	COG1609	Transcriptional regulator
LGI35_RS37305	COG0601	transmembrane transport
LGI35_RS37310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS37315	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS37320	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS37370	COG0183	Belongs to the thiolase family
LGI35_RS37375	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS37380	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS37430	COG0668	transmembrane transport
LGI35_RS37435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LGI35_RS37455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LGI35_RS37480	COG2353	YceI-like domain
LGI35_RS37525	COG1024	Enoyl-CoA hydratase
LGI35_RS37530	COG1132	(ABC) transporter
LGI35_RS37535	COG0137	argininosuccinate synthase activity
LGI35_RS37550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LGI35_RS37550	COG2080	2 iron, 2 sulfur cluster binding
LGI35_RS37560	COG3224	Antibiotic biosynthesis monooxygenase
LGI35_RS37590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LGI35_RS37610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LGI35_RS37615	COG3458	cephalosporin-C deacetylase activity
LGI35_RS37640	COG0297	glycogen (starch) synthase activity
LGI35_RS37645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LGI35_RS37650	COG3537	Alpha-1,2-mannosidase
LGI35_RS37665	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS37675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LGI35_RS37680	COG1993	acr, cog1993
LGI35_RS37685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LGI35_RS37710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LGI35_RS37720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LGI35_RS37740	COG2186	Transcriptional regulator
LGI35_RS37745	COG1879	ABC-type sugar transport system periplasmic component
LGI35_RS37750	COG1129	ABC transporter
LGI35_RS37760	COG4948	Mandelate Racemase Muconate Lactonizing
LGI35_RS37765	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS37780	COG3618	amidohydrolase
LGI35_RS37800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LGI35_RS37810	COG3279	Response regulator of the LytR AlgR family
LGI35_RS37820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LGI35_RS37825	COG3275	phosphorelay sensor kinase activity
LGI35_RS37850	COG0726	polysaccharide deacetylase
LGI35_RS37910	COG1053	succinate dehydrogenase
LGI35_RS37915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LGI35_RS37940	COG2182	Extracellular solute-binding protein
LGI35_RS37945	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LGI35_RS37950	COG0121	glutamine amidotransferase
LGI35_RS37955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LGI35_RS37960	COG3572	ergothioneine biosynthetic process
LGI35_RS37975	COG3858	chitin binding
LGI35_RS37975	COG1388	LysM domain
LGI35_RS37985	COG1609	Transcriptional regulator
LGI35_RS37995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LGI35_RS38000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LGI35_RS38005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LGI35_RS38015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LGI35_RS38020	COG1120	ATPase activity
LGI35_RS38045	COG2813	Specifically methylates the guanine in position
LGI35_RS38060	COG2186	Transcriptional regulator
LGI35_RS38065	COG4948	Mandelate Racemase Muconate Lactonizing
LGI35_RS38070	COG0395	ABC-type sugar transport system, permease component
LGI35_RS38075	COG1175	transmembrane transport
LGI35_RS38090	COG1946	Acyl-CoA thioesterase
LGI35_RS38105	COG2186	Transcriptional regulator
LGI35_RS38125	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LGI35_RS38145	COG1174	glycine betaine transport
LGI35_RS38150	COG1174	glycine betaine transport
LGI35_RS38165	COG1556	Lactate utilization protein
LGI35_RS38170	COG1139	Iron-sulfur cluster binding protein
LGI35_RS38175	COG0247	lactate metabolic process
LGI35_RS38180	COG1070	Carbohydrate kinase
LGI35_RS38185	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS38185	COG3347	Dehydrogenase
LGI35_RS38200	COG3250	beta-galactosidase activity
LGI35_RS38205	COG1129	ABC transporter
LGI35_RS38210	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS38215	COG1172	Belongs to the binding-protein-dependent transport system permease family
LGI35_RS38220	COG1879	ABC-type sugar transport system periplasmic component
LGI35_RS38225	COG1609	Transcriptional regulator
LGI35_RS38240	COG1024	Enoyl-CoA hydratase
LGI35_RS38245	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS38255	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS38260	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS38270	COG0601	transmembrane transport
LGI35_RS38275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS38280	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS38350	COG0477	Major facilitator Superfamily
LGI35_RS38355	COG1802	Transcriptional regulator
LGI35_RS38385	COG1289	transmembrane transporter activity
LGI35_RS38405	COG0542	response to heat
LGI35_RS38415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LGI35_RS38420	COG0583	DNA-binding transcription factor activity
LGI35_RS38425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LGI35_RS38440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LGI35_RS38560	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LGI35_RS38565	COG2271	Major facilitator Superfamily
LGI35_RS38570	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS38575	COG0277	FAD linked oxidase domain protein
LGI35_RS38580	COG1070	Carbohydrate kinase
LGI35_RS38610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LGI35_RS38620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LGI35_RS38625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LGI35_RS38635	COG2188	Transcriptional regulator
LGI35_RS38645	COG3647	Membrane
LGI35_RS38655	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS38670	COG3246	L-lysine catabolic process to acetate
LGI35_RS38680	COG2175	clavaminate synthase activity
LGI35_RS38685	COG2814	Major facilitator Superfamily
LGI35_RS38695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LGI35_RS38710	COG1175	transmembrane transport
LGI35_RS38715	COG0395	ABC-type sugar transport system, permease component
LGI35_RS38725	COG1609	Transcriptional regulator
LGI35_RS38740	COG1404	Belongs to the peptidase S8 family
LGI35_RS38765	COG1113	amino acid transport
LGI35_RS38770	COG0019	diaminopimelate decarboxylase activity
LGI35_RS38780	COG0702	epimerase
LGI35_RS38795	COG2226	methyltransferase
LGI35_RS38805	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS38825	COG1113	amino acid transport
LGI35_RS38830	COG1846	Transcriptional regulator
LGI35_RS38830	COG1940	carbohydrate kinase activity
LGI35_RS38835	COG1070	Carbohydrate kinase
LGI35_RS38875	COG1793	dna ligase
LGI35_RS38880	COG0431	NADPH-dependent FMN reductase
LGI35_RS38895	COG0386	Belongs to the glutathione peroxidase family
LGI35_RS38935	COG3594	Acyltransferase
LGI35_RS38940	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS38955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LGI35_RS38985	COG0697	spore germination
LGI35_RS38990	COG0583	DNA-binding transcription factor activity
LGI35_RS39030	COG1309	transcriptional regulator
LGI35_RS39045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LGI35_RS39070	COG1595	DNA-templated transcription, initiation
LGI35_RS39080	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LGI35_RS39085	COG1940	carbohydrate kinase activity
LGI35_RS39090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS39110	COG0330	HflC and HflK could
LGI35_RS39115	COG2890	protein-(glutamine-N5) methyltransferase activity
LGI35_RS39120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LGI35_RS39120	COG1796	DNA polymerase
LGI35_RS39170	COG0367	asparagine synthase
LGI35_RS39265	COG0277	FAD linked oxidase domain protein
LGI35_RS39285	COG2124	cytochrome p450
LGI35_RS39310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS39320	COG0328	RNA-DNA hybrid ribonuclease activity
LGI35_RS39325	COG0736	holo-[acyl-carrier-protein] synthase activity
LGI35_RS39335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LGI35_RS39350	COG0702	epimerase
LGI35_RS39355	COG2188	Transcriptional regulator
LGI35_RS39365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LGI35_RS39390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LGI35_RS39470	COG0235	Class ii aldolase
LGI35_RS39480	COG1522	sequence-specific DNA binding
LGI35_RS39490	COG0477	Major facilitator Superfamily
LGI35_RS39500	COG3119	arylsulfatase activity
LGI35_RS39585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS39600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LGI35_RS39605	COG1834	amidinotransferase
LGI35_RS39620	COG0831	urea catabolic process
LGI35_RS39620	COG0832	Belongs to the urease beta subunit family
LGI35_RS39625	COG0804	urea catabolic process
LGI35_RS39630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LGI35_RS39635	COG0477	Major facilitator Superfamily
LGI35_RS39670	COG3537	Alpha-1,2-mannosidase
LGI35_RS39675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LGI35_RS39675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LGI35_RS39685	COG0515	serine threonine protein kinase
LGI35_RS39695	COG0351	phosphomethylpyrimidine kinase
LGI35_RS39700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS39735	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS39745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS39750	COG0183	Belongs to the thiolase family
LGI35_RS39770	COG1024	Enoyl-CoA hydratase
LGI35_RS39775	COG1960	acyl-CoA dehydrogenase activity
LGI35_RS39785	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LGI35_RS39790	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS39795	COG1024	Enoyl-CoA hydratase
LGI35_RS39800	COG1946	Acyl-CoA thioesterase
LGI35_RS39805	COG0183	Belongs to the thiolase family
LGI35_RS39835	COG0129	dihydroxy-acid dehydratase activity
LGI35_RS39870	COG0601	transmembrane transport
LGI35_RS39875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS39890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LGI35_RS39900	COG0366	Alpha amylase catalytic
LGI35_RS39905	COG0366	Alpha amylase catalytic
LGI35_RS39935	COG0395	ABC-type sugar transport system, permease component
LGI35_RS39940	COG1175	transmembrane transport
LGI35_RS39975	COG0789	Transcriptional regulator
LGI35_RS39985	COG3293	Transposase
LGI35_RS39995	COG1846	Transcriptional regulator
LGI35_RS40005	COG1174	glycine betaine transport
LGI35_RS40010	COG1174	glycine betaine transport
LGI35_RS40020	COG1732	Glycine betaine
LGI35_RS40035	COG0596	Alpha beta hydrolase
LGI35_RS40060	COG2890	protein-(glutamine-N5) methyltransferase activity
LGI35_RS40065	COG2267	carboxylic ester hydrolase activity
LGI35_RS40075	COG0488	(ABC) transporter
LGI35_RS40095	COG1280	lysine exporter protein (LysE YggA)
LGI35_RS40100	COG0009	L-threonylcarbamoyladenylate synthase
LGI35_RS40105	COG0596	Alpha beta hydrolase
LGI35_RS40160	COG3852	Histidine kinase
LGI35_RS40170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LGI35_RS40175	COG2409	Drug exporters of the RND superfamily
LGI35_RS40180	COG1119	ATPase activity
LGI35_RS40215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LGI35_RS40250	COG0583	DNA-binding transcription factor activity
LGI35_RS40265	COG2364	Membrane
LGI35_RS40280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LGI35_RS40290	COG1090	epimerase
LGI35_RS40295	COG4221	oxidoreductase activity
LGI35_RS40300	COG4977	sequence-specific DNA binding
LGI35_RS40315	COG2124	cytochrome p450
LGI35_RS40330	COG2986	histidine ammonia-lyase
LGI35_RS40345	COG4221	oxidoreductase activity
LGI35_RS40395	COG3467	pyridoxamine 5'-phosphate
LGI35_RS40445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LGI35_RS40445	COG2755	lipolytic protein G-D-S-L family
LGI35_RS40460	COG4977	sequence-specific DNA binding
LGI35_RS40485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LGI35_RS40505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS40515	COG0583	DNA-binding transcription factor activity
LGI35_RS40525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LGI35_RS40530	COG2610	gluconate transmembrane transporter activity
LGI35_RS40535	COG4948	Mandelate Racemase Muconate Lactonizing
LGI35_RS40570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LGI35_RS40585	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS40600	COG1609	Transcriptional regulator
LGI35_RS40620	COG0667	Aldo Keto reductase
LGI35_RS40645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LGI35_RS40685	COG0531	amino acid
LGI35_RS40690	COG1725	Transcriptional regulator
LGI35_RS40695	COG1131	(ABC) transporter
LGI35_RS40715	COG0174	glutamine synthetase
LGI35_RS40730	COG4689	acetoacetate decarboxylase
LGI35_RS40745	COG0179	Fumarylacetoacetate (FAA) hydrolase
LGI35_RS40760	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS40765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LGI35_RS40770	COG1846	Transcriptional regulator
LGI35_RS40785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LGI35_RS40840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS40845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LGI35_RS40850	COG4521	taurine ABC transporter
LGI35_RS40855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LGI35_RS40870	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS40875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS40885	COG0601	transmembrane transport
LGI35_RS40890	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS40895	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS40900	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS40905	COG1802	Transcriptional regulator
LGI35_RS40935	COG2226	methyltransferase
LGI35_RS40950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LGI35_RS40950	COG0512	Glutamine amidotransferase of anthranilate synthase
LGI35_RS40965	COG2318	DinB family
LGI35_RS40970	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS40975	COG3896	Chloramphenicol phosphotransferase-like protein
LGI35_RS40980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LGI35_RS41005	COG0243	molybdopterin cofactor binding
LGI35_RS41010	COG4988	ABC transporter
LGI35_RS41015	COG1294	oxidase, subunit
LGI35_RS41020	COG1271	oxidase subunit
LGI35_RS41045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LGI35_RS41055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LGI35_RS41075	COG2252	PERMEase
LGI35_RS41080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LGI35_RS41085	COG4608	Belongs to the ABC transporter superfamily
LGI35_RS41090	COG0444	Belongs to the ABC transporter superfamily
LGI35_RS41095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGI35_RS41100	COG0601	transmembrane transport
LGI35_RS41105	COG4166	transmembrane transport
LGI35_RS41110	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS41115	COG2186	Transcriptional regulator
LGI35_RS41125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LGI35_RS41130	COG1304	FMN binding
LGI35_RS41135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LGI35_RS41145	COG0549	Belongs to the carbamate kinase family
LGI35_RS41155	COG1953	Uracil, thiamine, allantoin
LGI35_RS41175	COG0640	Transcriptional regulator
LGI35_RS41185	COG1309	transcriptional regulator
LGI35_RS41190	COG0702	epimerase
LGI35_RS41235	COG1819	glycosyl
LGI35_RS41255	COG2186	Transcriptional regulator
LGI35_RS41260	COG4948	Mandelate Racemase Muconate Lactonizing
LGI35_RS41310	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS41320	COG4565	transcriptional regulatory protein
LGI35_RS41325	COG3290	protein histidine kinase activity
LGI35_RS41340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LGI35_RS41370	COG0531	amino acid
LGI35_RS41375	COG2814	Major facilitator Superfamily
LGI35_RS41400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LGI35_RS41415	COG1595	DNA-templated transcription, initiation
LGI35_RS41445	COG1414	Transcriptional regulator
LGI35_RS41450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS41470	COG3437	response regulator, receiver
LGI35_RS41470	COG4999	Histidine kinase
LGI35_RS41470	COG2205	protein histidine kinase activity
LGI35_RS41470	COG3850	Histidine kinase
LGI35_RS41505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LGI35_RS41515	COG1309	transcriptional regulator
LGI35_RS41525	COG0765	amino acid transport
LGI35_RS41530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LGI35_RS41545	COG0477	Major facilitator Superfamily
LGI35_RS41550	COG1309	transcriptional regulator
LGI35_RS41555	COG1473	amidohydrolase
LGI35_RS41585	COG0395	ABC-type sugar transport system, permease component
LGI35_RS41590	COG1175	transmembrane transport
LGI35_RS41615	COG1609	Transcriptional regulator
LGI35_RS41630	COG0395	ABC-type sugar transport system, permease component
LGI35_RS41645	COG1609	Transcriptional regulator
LGI35_RS41655	COG0583	DNA-binding transcription factor activity
LGI35_RS41670	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LGI35_RS41680	COG1609	Transcriptional regulator
LGI35_RS41690	COG2182	Extracellular solute-binding protein
LGI35_RS41695	COG1175	transmembrane transport
LGI35_RS41700	COG0395	ABC-type sugar transport system, permease component
LGI35_RS41715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LGI35_RS41720	COG0739	heme binding
LGI35_RS41730	COG2197	response regulator
LGI35_RS41735	COG4585	Histidine kinase
LGI35_RS41765	COG2186	Transcriptional regulator
LGI35_RS41770	COG1501	Belongs to the glycosyl hydrolase 31 family
LGI35_RS41780	COG0395	ABC-type sugar transport system, permease component
LGI35_RS41795	COG1609	Transcriptional regulator
LGI35_RS41825	COG0842	Transport permease protein
LGI35_RS41855	COG2267	carboxylic ester hydrolase activity
LGI35_RS41860	COG1024	Enoyl-CoA hydratase
LGI35_RS41865	COG0318	PFAM AMP-dependent synthetase and ligase
LGI35_RS41875	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS41890	COG0183	Belongs to the thiolase family
LGI35_RS41920	COG3903	Transcriptional regulator
LGI35_RS41920	COG3629	intracellular signal transduction
LGI35_RS41950	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
LGI35_RS41960	COG1012	belongs to the aldehyde dehydrogenase family
LGI35_RS41965	COG0477	Major facilitator Superfamily
LGI35_RS41985	COG0583	DNA-binding transcription factor activity
LGI35_RS41990	COG1301	dicarboxylic acid transport
LGI35_RS42010	COG1396	sequence-specific DNA binding
LGI35_RS42015	COG1247	-acetyltransferase
LGI35_RS42025	COG1024	Enoyl-CoA hydratase
LGI35_RS42025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LGI35_RS42065	COG0375	protein maturation
LGI35_RS42070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LGI35_RS42075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LGI35_RS42090	COG0309	Hydrogenase expression formation protein (HypE)
LGI35_RS42115	COG1595	DNA-templated transcription, initiation
LGI35_RS42135	COG1914	H( )-stimulated, divalent metal cation uptake system
LGI35_RS42140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LGI35_RS42150	COG0667	Aldo Keto reductase
LGI35_RS42160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LGI35_RS42165	COG1349	DNA-binding transcription factor activity
LGI35_RS42170	COG0604	alcohol dehydrogenase
LGI35_RS42180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LGI35_RS42180	COG1116	anion transmembrane transporter activity
LGI35_RS42200	COG1414	Transcriptional regulator
LGI35_RS42205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGI35_RS42210	COG1024	Enoyl-CoA hydratase
LGI35_RS42225	COG2267	carboxylic ester hydrolase activity
LGI35_RS42250	COG3384	dioxygenase
LGI35_RS42260	COG0492	ferredoxin-NADP+ reductase activity
LGI35_RS42270	COG3971	2-oxopent-4-enoate hydratase activity
LGI35_RS42275	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LGI35_RS42280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LGI35_RS42290	COG0596	Alpha beta hydrolase
LGI35_RS42295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LGI35_RS42300	COG1228	amidohydrolase
LGI35_RS42320	COG0745	RESPONSE REGULATOR receiver
LGI35_RS42340	COG0671	phosphoesterase, PA-phosphatase related
LGI35_RS42345	COG1968	undecaprenyl-diphosphatase activity
LGI35_RS42365	COG4585	Histidine kinase
LGI35_RS42370	COG2197	response regulator
LGI35_RS42390	COG0640	Transcriptional regulator
LGI35_RS42440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LGI35_RS42470	COG2353	YceI-like domain
LGI35_RS42480	COG1366	Belongs to the anti-sigma-factor antagonist family
LGI35_RS42480	COG2172	sigma factor antagonist activity
LGI35_RS42480	COG2208	phosphoserine phosphatase activity
LGI35_RS42505	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS42510	COG2072	flavoprotein involved in K transport
LGI35_RS42515	COG2271	Major facilitator Superfamily
LGI35_RS42520	COG1021	2,3-dihydroxybenzoate-AMP ligase
LGI35_RS42555	COG3250	beta-galactosidase activity
LGI35_RS42580	COG1653	transport
LGI35_RS42585	COG0395	ABC-type sugar transport system, permease component
LGI35_RS42590	COG4209	transmembrane transport
LGI35_RS42595	COG3458	cephalosporin-C deacetylase activity
LGI35_RS42600	COG1609	Transcriptional regulator
LGI35_RS42640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LGI35_RS42690	COG2945	thiolester hydrolase activity
LGI35_RS42690	COG0596	Alpha beta hydrolase
LGI35_RS42715	COG3424	synthase
LGI35_RS42730	COG3104	oligopeptide transport
LGI35_RS42735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LGI35_RS42745	COG2233	PERMEase
LGI35_RS42750	COG0402	S-adenosylhomocysteine deaminase activity
LGI35_RS42760	COG1609	Transcriptional regulator
LGI35_RS42790	COG0702	epimerase
LGI35_RS42800	COG3046	protein related to deoxyribodipyrimidine photolyase
LGI35_RS42810	COG1846	Transcriptional regulator
LGI35_RS42815	COG2409	Drug exporters of the RND superfamily
LGI35_RS42845	COG1028	Short-chain dehydrogenase reductase Sdr
LGI35_RS42855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LGI35_RS42880	COG1595	DNA-templated transcription, initiation
LGI35_RS42935	COG0596	Alpha beta hydrolase
LGI35_RS42995	COG0596	Alpha beta hydrolase
LGI35_RS43005	COG2264	protein methyltransferase activity
LGI35_RS43030	COG2045	Belongs to the ComB family
LGI35_RS43050	COG0277	FAD linked oxidase domain protein
LGI35_RS43065	COG0604	alcohol dehydrogenase
LGI35_RS43070	COG1309	transcriptional regulator
LGI35_RS43095	COG0326	Molecular chaperone. Has ATPase activity
LGI35_RS43120	COG0714	Associated with various cellular activities
LGI35_RS43170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LGI35_RS43175	COG3622	Belongs to the hyi family
LGI35_RS43180	COG2271	Major facilitator Superfamily
LGI35_RS43185	COG0235	Class ii aldolase
LGI35_RS43190	COG3395	kinase activity
LGI35_RS43195	COG2084	Dehydrogenase
LGI35_RS43215	COG3293	Transposase
LGI35_RS43275	COG1959	2 iron, 2 sulfur cluster binding
LGI35_RS43280	COG1017	nitric oxide dioxygenase activity
LGI35_RS43280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LGI35_RS43295	COG0701	Predicted permease
LGI35_RS43320	COG1940	carbohydrate kinase activity
LGI35_RS43330	COG1175	transmembrane transport
LGI35_RS43335	COG0395	ABC-type sugar transport system, permease component
LGI35_RS43340	COG3345	alpha-galactosidase
LGI35_RS43405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LGI35_RS43420	COG0596	Alpha beta hydrolase
LGI35_RS43425	COG1335	isochorismatase
LGI35_RS43450	COG0477	Major facilitator Superfamily
LGI35_RS43460	COG2309	aminopeptidase activity
LGI35_RS43555	COG3387	PFAM Glycoside hydrolase 15-related
LGI35_RS43580	COG0628	permease
LGI35_RS43595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LGI35_RS43600	COG0443	Heat shock 70 kDa protein
LGI35_RS43635	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LGI35_RS43665	COG0596	Alpha beta hydrolase
LGI35_RS43675	COG2318	DinB family
LGI35_RS43685	COG1278	Cold shock
LGI35_RS43695	COG2318	DinB family
LGI35_RS43725	COG2770	Histidine kinase
LGI35_RS43725	COG2208	phosphoserine phosphatase activity
LGI35_RS43735	COG1476	TRANSCRIPTIONal
LGI35_RS43765	COG1649	PFAM Uncharacterised BCR, COG1649
LGI35_RS43780	COG0583	DNA-binding transcription factor activity
LGI35_RS43965	COG0431	NADPH-dependent FMN reductase
LGI35_RS43970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LGI35_RS43985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LGI35_RS44175	COG3209	COG3209 Rhs family protein
LGI35_RS44190	COG0069	glutamate synthase activity
LGI35_RS44195	COG1366	Belongs to the anti-sigma-factor antagonist family
LGI35_RS44240	COG2208	phosphoserine phosphatase activity
LGI35_RS44240	COG2770	Histidine kinase
LGI35_RS44270	COG1404	Belongs to the peptidase S8 family
LGI35_RS44270	COG1404	Belongs to the peptidase S8 family
LGI35_RS44350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LGI35_RS44365	COG0583	DNA-binding transcription factor activity
LGI35_RS44415	COG2828	Protein conserved in bacteria
LGI35_RS44430	COG4249	Peptidase C14 caspase catalytic subunit p20
LGI35_RS44430	COG2319	Wd-40 repeat
LGI35_RS44530	COG1595	DNA-templated transcription, initiation
LGI35_RS44590	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LGI35_RS44620	COG3209	COG3209 Rhs family protein
LGI35_RS44620	COG4104	PAAR repeat-containing protein
LGI35_RS44705	COG1215	transferase activity, transferring glycosyl groups
LGI35_RS44725	COG2267	carboxylic ester hydrolase activity
LGI35_RS44810	COG2801	Transposase and inactivated derivatives
LGI35_RS44840	COG0501	Belongs to the peptidase M48B family
LGI35_RS44880	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LGI35_RS44965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LGI35_RS45060	COG2205	protein histidine kinase activity
LGI35_RS45165	COG3293	Transposase
LGI35_RS45205	COG2755	lipolytic protein G-D-S-L family
LGI35_RS45250	COG0693	protein deglycase activity
LGI35_RS45260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LGI35_RS45285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LGI35_RS45370	COG1595	DNA-templated transcription, initiation
LGI35_RS45415	COG0693	protein deglycase activity
LGI35_RS45440	COG0656	L-ascorbic acid biosynthetic process
LGI35_RS45485	COG0587	DNA-directed DNA polymerase activity
LGI35_RS45640	COG2205	protein histidine kinase activity
LGI35_RS45670	COG2205	protein histidine kinase activity
LGI35_RS45905	COG1192	Involved in chromosome partitioning
LGI35_RS45950	COG1793	dna ligase
LGI35_RS46220	COG1940	carbohydrate kinase activity
LGI35_RS46225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LGI35_RS46250	COG0697	spore germination