locus-tag	class	description
K2224_RS00030	COG1077	Cell shape determining protein MreB Mrl
K2224_RS00035	COG0588	phosphoglycerate mutase activity
K2224_RS00040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K2224_RS00095	COG1070	Carbohydrate kinase
K2224_RS00100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K2224_RS00105	COG0358	DNA primase activity
K2224_RS00120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K2224_RS00130	COG0243	molybdopterin cofactor binding
K2224_RS00135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K2224_RS00160	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K2224_RS00185	COG1473	amidohydrolase
K2224_RS00200	COG2146	nitrite reductase [NAD(P)H] activity
K2224_RS00200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K2224_RS00215	COG0531	amino acid
K2224_RS00225	COG2175	clavaminate synthase activity
K2224_RS00250	COG0535	radical SAM domain protein
K2224_RS00280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K2224_RS00280	COG0574	Belongs to the PEP-utilizing enzyme family
K2224_RS00285	COG0477	Major facilitator Superfamily
K2224_RS00310	COG0477	Major facilitator Superfamily
K2224_RS00315	COG0667	Aldo Keto reductase
K2224_RS00325	COG0423	glycine-tRNA ligase activity
K2224_RS00335	COG1121	(ABC) transporter
K2224_RS00340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K2224_RS00350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K2224_RS00355	COG1381	Involved in DNA repair and RecF pathway recombination
K2224_RS00415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K2224_RS00435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K2224_RS00450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K2224_RS00465	COG1486	melibiose metabolic process
K2224_RS00485	COG1234	tRNA 3'-trailer cleavage
K2224_RS00490	COG0537	adenosine 5'-monophosphoramidase activity
K2224_RS00510	COG0484	heat shock protein binding
K2224_RS00515	COG1420	regulation of RNA biosynthetic process
K2224_RS00550	COG0481	GTPase activity
K2224_RS00555	COG0268	Binds directly to 16S ribosomal RNA
K2224_RS00575	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K2224_RS00620	COG1307	EDD domain protein, DegV family
K2224_RS00630	COG0495	leucyl-tRNA aminoacylation
K2224_RS00670	COG0799	negative regulation of ribosome biogenesis
K2224_RS00680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K2224_RS00695	COG0501	Belongs to the peptidase M48B family
K2224_RS00710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K2224_RS00720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K2224_RS00730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K2224_RS00735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K2224_RS00740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K2224_RS00745	COG1530	ribonuclease E activity
K2224_RS00800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS00835	COG0772	Belongs to the SEDS family
K2224_RS00840	COG0768	penicillin binding
K2224_RS00855	COG1077	Cell shape determining protein MreB Mrl
K2224_RS00860	COG0105	UTP biosynthetic process
K2224_RS00870	COG0285	dihydrofolate synthase activity
K2224_RS00875	COG0768	penicillin binding
K2224_RS00885	COG0525	valine-tRNA ligase activity
K2224_RS00895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K2224_RS00900	COG0740	serine-type endopeptidase activity
K2224_RS00905	COG0740	serine-type endopeptidase activity
K2224_RS00910	COG0544	peptidyl-prolyl cis-trans isomerase activity
K2224_RS00935	COG0475	glutathione-regulated potassium exporter activity
K2224_RS00945	COG4552	Acetyltransferase involved in intracellular survival and related
K2224_RS00955	COG0698	ribose 5-phosphate isomerase
K2224_RS00960	COG1113	amino acid transport
K2224_RS00970	COG1113	amino acid transport
K2224_RS00975	COG1113	amino acid transport
K2224_RS00980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K2224_RS00985	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K2224_RS01005	COG2337	Toxic component of a toxin-antitoxin (TA) module
K2224_RS01020	COG4266	Belongs to the allantoicase family
K2224_RS01065	COG0668	transmembrane transport
K2224_RS01075	COG1940	carbohydrate kinase activity
K2224_RS01075	COG1846	Transcriptional regulator
K2224_RS01080	COG1653	transport
K2224_RS01085	COG1175	transmembrane transport
K2224_RS01090	COG0395	ABC-type sugar transport system, permease component
K2224_RS01095	COG1486	melibiose metabolic process
K2224_RS01110	COG2186	Transcriptional regulator
K2224_RS01120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K2224_RS01175	COG0629	single-stranded DNA binding
K2224_RS01260	COG3103	Sh3 type 3 domain protein
K2224_RS01260	COG1388	LysM domain
K2224_RS01260	COG0791	NLP P60 protein
K2224_RS01275	COG0584	glycerophosphoryl diester phosphodiesterase
K2224_RS01300	COG2255	four-way junction helicase activity
K2224_RS01415	COG1404	Belongs to the peptidase S8 family
K2224_RS01425	COG1404	Belongs to the peptidase S8 family
K2224_RS01440	COG1674	ftsk spoiiie
K2224_RS01455	COG0443	Heat shock 70 kDa protein
K2224_RS01470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2224_RS01480	COG1846	Transcriptional regulator
K2224_RS01505	COG1077	Cell shape determining protein MreB Mrl
K2224_RS01515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K2224_RS01525	COG1131	(ABC) transporter
K2224_RS01540	COG3962	Belongs to the TPP enzyme family
K2224_RS01545	COG3718	enzyme involved in inositol metabolism
K2224_RS01565	COG0673	inositol 2-dehydrogenase activity
K2224_RS01570	COG2814	Major facilitator Superfamily
K2224_RS01585	COG1609	Transcriptional regulator
K2224_RS01590	COG0673	inositol 2-dehydrogenase activity
K2224_RS01605	COG0586	Pfam SNARE associated Golgi protein
K2224_RS01610	COG2608	mercury ion transmembrane transporter activity
K2224_RS01620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K2224_RS01635	COG0673	inositol 2-dehydrogenase activity
K2224_RS01640	COG1609	Transcriptional regulator
K2224_RS01645	COG1082	Xylose isomerase domain protein TIM barrel
K2224_RS01650	COG1472	Belongs to the glycosyl hydrolase 3 family
K2224_RS01665	COG1554	hydrolase, family 65, central catalytic
K2224_RS01670	COG1129	ABC transporter
K2224_RS01670	COG0842	Transport permease protein
K2224_RS01680	COG1309	transcriptional regulator
K2224_RS01700	COG1946	Acyl-CoA thioesterase
K2224_RS01710	COG1309	transcriptional regulator
K2224_RS01715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K2224_RS01730	COG1960	acyl-CoA dehydrogenase activity
K2224_RS01755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2224_RS01760	COG0589	response to stress
K2224_RS01765	COG4977	sequence-specific DNA binding
K2224_RS01770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K2224_RS01780	COG2910	NAD(P)H-binding
K2224_RS01790	COG3979	chitinase
K2224_RS01805	COG0745	RESPONSE REGULATOR receiver
K2224_RS01835	COG0438	transferase activity, transferring glycosyl groups
K2224_RS01840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K2224_RS01905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS01915	COG3473	Maleate cis-trans isomerase
K2224_RS01920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2224_RS01925	COG0154	amidase activity
K2224_RS01940	COG0765	amino acid transport
K2224_RS01945	COG0765	amino acid transport
K2224_RS01950	COG1126	abc transporter atp-binding protein
K2224_RS02015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2224_RS02020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2224_RS02025	COG2188	Transcriptional regulator
K2224_RS02030	COG1846	Transcriptional regulator
K2224_RS02030	COG1940	carbohydrate kinase activity
K2224_RS02035	COG0673	inositol 2-dehydrogenase activity
K2224_RS02040	COG4702	Belongs to the UPF0303 family
K2224_RS02045	COG0179	Fumarylacetoacetate (FAA) hydrolase
K2224_RS02050	COG0706	membrane insertase activity
K2224_RS02060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K2224_RS02070	COG2733	membrane
K2224_RS02100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K2224_RS02110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K2224_RS02125	COG2205	protein histidine kinase activity
K2224_RS02135	COG0477	Major facilitator Superfamily
K2224_RS02155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K2224_RS02165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K2224_RS02170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K2224_RS02175	COG1263	PTS System
K2224_RS02180	COG1263	PTS System
K2224_RS02190	COG1132	(ABC) transporter
K2224_RS02200	COG1234	tRNA 3'-trailer cleavage
K2224_RS02225	COG1113	amino acid transport
K2224_RS02235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K2224_RS02245	COG1335	isochorismatase
K2224_RS02280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K2224_RS02285	COG0222	ribosome binding
K2224_RS02300	COG0277	FAD linked oxidase domain protein
K2224_RS02305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K2224_RS02315	COG1174	glycine betaine transport
K2224_RS02325	COG1174	glycine betaine transport
K2224_RS02370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K2224_RS02375	COG2080	2 iron, 2 sulfur cluster binding
K2224_RS02385	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K2224_RS02395	COG2814	Major facilitator Superfamily
K2224_RS02400	COG0583	DNA-binding transcription factor activity
K2224_RS02410	COG1678	Uncharacterized ACR, COG1678
K2224_RS02415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K2224_RS02420	COG0776	regulation of translation
K2224_RS02430	COG3973	AAA domain
K2224_RS02450	COG2223	nitrite transmembrane transporter activity
K2224_RS02465	COG0583	DNA-binding transcription factor activity
K2224_RS02480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K2224_RS02485	COG0793	Belongs to the peptidase S41A family
K2224_RS02490	COG2177	Part of the ABC transporter FtsEX involved in
K2224_RS02495	COG2884	Cell division ATP-binding protein ftsE
K2224_RS02510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K2224_RS02515	COG0515	serine threonine protein kinase
K2224_RS02520	COG0515	serine threonine protein kinase
K2224_RS02530	COG1653	transport
K2224_RS02535	COG1175	transmembrane transport
K2224_RS02540	COG0395	ABC-type sugar transport system, permease component
K2224_RS02615	COG0463	Glycosyl transferase, family 2
K2224_RS02635	COG1309	transcriptional regulator
K2224_RS02645	COG1134	teichoic acid transport
K2224_RS02645	COG1388	LysM domain
K2224_RS02650	COG2902	Dehydrogenase
K2224_RS02670	COG0653	protein targeting
K2224_RS02680	COG3214	Protein conserved in bacteria
K2224_RS02685	COG2197	response regulator
K2224_RS02690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K2224_RS02700	COG0823	Involved in the tonB-independent uptake of proteins
K2224_RS02705	COG5000	phosphorelay sensor kinase activity
K2224_RS02705	COG5002	protein histidine kinase activity
K2224_RS02710	COG0745	RESPONSE REGULATOR receiver
K2224_RS02715	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K2224_RS02735	COG0714	Associated with various cellular activities
K2224_RS02775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K2224_RS02785	COG1482	cell wall glycoprotein biosynthetic process
K2224_RS02795	COG2835	tetraacyldisaccharide 4'-kinase activity
K2224_RS02800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2224_RS02835	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K2224_RS02840	COG0778	Nitroreductase
K2224_RS02840	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
K2224_RS02870	COG1316	TRANSCRIPTIONal
K2224_RS02885	COG1316	TRANSCRIPTIONal
K2224_RS02905	COG1316	TRANSCRIPTIONal
K2224_RS02985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K2224_RS03015	COG2205	protein histidine kinase activity
K2224_RS03020	COG0745	RESPONSE REGULATOR receiver
K2224_RS03025	COG3104	oligopeptide transport
K2224_RS03055	COG1366	Belongs to the anti-sigma-factor antagonist family
K2224_RS03060	COG1191	sigma factor activity
K2224_RS03065	COG1228	amidohydrolase
K2224_RS03080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K2224_RS03115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K2224_RS03130	COG2755	lipolytic protein G-D-S-L family
K2224_RS03135	COG0183	Belongs to the thiolase family
K2224_RS03160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K2224_RS03165	COG0297	glycogen (starch) synthase activity
K2224_RS03175	COG1136	(ABC) transporter
K2224_RS03180	COG0577	efflux transmembrane transporter activity
K2224_RS03185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2224_RS03210	COG0148	phosphopyruvate hydratase activity
K2224_RS03225	COG2124	cytochrome p450
K2224_RS03235	COG2814	Major facilitator Superfamily
K2224_RS03270	COG0515	serine threonine protein kinase
K2224_RS03270	COG2815	serine threonine protein kinase
K2224_RS03305	COG2814	Major facilitator Superfamily
K2224_RS03335	COG4585	Histidine kinase
K2224_RS03350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K2224_RS03355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K2224_RS03360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K2224_RS03365	COG0193	aminoacyl-tRNA hydrolase activity
K2224_RS03370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K2224_RS03380	COG1309	transcriptional regulator
K2224_RS03385	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS03405	COG2197	response regulator
K2224_RS03410	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K2224_RS03425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K2224_RS03440	COG0488	(ABC) transporter
K2224_RS03485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K2224_RS03490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K2224_RS03495	COG3583	domain protein
K2224_RS03495	COG3584	3D domain protein
K2224_RS03500	COG0084	hydrolase, TatD family'
K2224_RS03525	COG0442	prolyl-tRNA aminoacylation
K2224_RS03550	COG0793	Belongs to the peptidase S41A family
K2224_RS03550	COG4946	Tricorn protease homolog
K2224_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS03565	COG2267	carboxylic ester hydrolase activity
K2224_RS03570	COG2072	flavoprotein involved in K transport
K2224_RS03605	COG1725	Transcriptional regulator
K2224_RS03610	COG2205	protein histidine kinase activity
K2224_RS03620	COG0789	Transcriptional regulator
K2224_RS03625	COG1819	glycosyl
K2224_RS03645	COG0521	Mo-molybdopterin cofactor biosynthetic process
K2224_RS03645	COG0315	cyclic pyranopterin monophosphate synthase activity
K2224_RS03650	COG0315	cyclic pyranopterin monophosphate synthase activity
K2224_RS03660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K2224_RS03665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K2224_RS03675	COG3263	regulation of cellular component size
K2224_RS03690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K2224_RS03700	COG1970	mechanosensitive ion channel activity
K2224_RS03710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K2224_RS03715	COG0477	Major facilitator Superfamily
K2224_RS03720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K2224_RS03725	COG2188	Transcriptional regulator
K2224_RS03740	COG0640	Transcriptional regulator
K2224_RS03750	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS03780	COG3191	aminopeptidase activity
K2224_RS03805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K2224_RS03810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K2224_RS03810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K2224_RS03810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2224_RS03815	COG1105	Belongs to the carbohydrate kinase PfkB family
K2224_RS03820	COG1349	DNA-binding transcription factor activity
K2224_RS03830	COG1247	-acetyltransferase
K2224_RS03855	COG1846	Transcriptional regulator
K2224_RS03875	COG1309	transcriptional regulator
K2224_RS03900	COG0514	ATP-dependent DNA helicase (RecQ)
K2224_RS03905	COG2205	protein histidine kinase activity
K2224_RS03925	COG0640	Transcriptional regulator
K2224_RS03935	COG1686	Belongs to the peptidase S11 family
K2224_RS03955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K2224_RS03970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2224_RS03980	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K2224_RS04010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K2224_RS04120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K2224_RS04135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2224_RS04135	COG0515	serine threonine protein kinase
K2224_RS04140	COG1309	transcriptional regulator
K2224_RS04160	COG0259	pyridoxamine-phosphate oxidase activity
K2224_RS04175	COG1024	Enoyl-CoA hydratase
K2224_RS04190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K2224_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS04215	COG1960	acyl-CoA dehydrogenase activity
K2224_RS04220	COG1960	acyl-CoA dehydrogenase activity
K2224_RS04250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K2224_RS04260	COG0516	GMP reductase activity
K2224_RS04270	COG1595	DNA-templated transcription, initiation
K2224_RS04285	COG0583	DNA-binding transcription factor activity
K2224_RS04295	COG4221	oxidoreductase activity
K2224_RS04310	COG0459	protein refolding
K2224_RS04315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K2224_RS04320	COG0772	Belongs to the SEDS family
K2224_RS04335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K2224_RS04360	COG0802	atpase or kinase
K2224_RS04370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K2224_RS04380	COG0736	holo-[acyl-carrier-protein] synthase activity
K2224_RS04385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2224_RS04395	COG1072	(Pantothenic acid kinase))
K2224_RS04400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2224_RS04405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K2224_RS04410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K2224_RS04420	COG0101	tRNA pseudouridine synthase activity
K2224_RS04425	COG0203	ribosomal protein L17
K2224_RS04430	COG0202	RNA polymerase activity
K2224_RS04435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K2224_RS04440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K2224_RS04445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K2224_RS04450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K2224_RS04455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K2224_RS04465	COG0563	adenylate kinase activity
K2224_RS04475	COG0200	Binds to the 23S rRNA
K2224_RS04480	COG1841	ribosomal large subunit assembly
K2224_RS04485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K2224_RS04490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K2224_RS04495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K2224_RS04500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K2224_RS04505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K2224_RS04510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K2224_RS04515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K2224_RS04520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K2224_RS04525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K2224_RS04530	COG0255	Belongs to the universal ribosomal protein uL29 family
K2224_RS04535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K2224_RS04540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K2224_RS04545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K2224_RS04550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K2224_RS04555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K2224_RS04560	COG0089	rRNA binding
K2224_RS04565	COG0088	Forms part of the polypeptide exit tunnel
K2224_RS04570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K2224_RS04575	COG0051	transcription antitermination factor activity, RNA binding
K2224_RS04580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K2224_RS04585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K2224_RS04590	COG0049	tRNA binding
K2224_RS04595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K2224_RS04605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K2224_RS04610	COG0085	RNA polymerase activity
K2224_RS04615	COG0222	ribosome binding
K2224_RS04620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K2224_RS04630	COG0081	regulation of translation
K2224_RS04635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K2224_RS04640	COG0250	Participates in transcription elongation, termination and antitermination
K2224_RS04655	COG0436	Aminotransferase
K2224_RS04660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K2224_RS04665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K2224_RS04675	COG2030	dehydratase
K2224_RS04680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K2224_RS04700	COG0702	epimerase
K2224_RS04710	COG1666	GTP binding
K2224_RS04725	COG3304	Inner membrane component domain
K2224_RS04730	COG0501	Belongs to the peptidase M48B family
K2224_RS04735	COG1007	ATP synthesis coupled electron transport
K2224_RS04745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K2224_RS04750	COG0713	ATP synthesis coupled electron transport
K2224_RS04760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2224_RS04765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K2224_RS04770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2224_RS04775	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2224_RS04780	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2224_RS04795	COG4585	Histidine kinase
K2224_RS04800	COG4585	Histidine kinase
K2224_RS04810	COG0674	pyruvate-flavodoxin oxidoreductase activity
K2224_RS04810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K2224_RS04815	COG1013	pyruvate-flavodoxin oxidoreductase activity
K2224_RS04840	COG0142	geranyltranstransferase activity
K2224_RS04855	COG1007	ATP synthesis coupled electron transport
K2224_RS04865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K2224_RS04870	COG0713	ATP synthesis coupled electron transport
K2224_RS04875	COG0839	Belongs to the complex I subunit 6 family
K2224_RS04880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2224_RS04885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K2224_RS04890	COG1034	ATP synthesis coupled electron transport
K2224_RS04895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K2224_RS04905	COG0649	NAD binding
K2224_RS04910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2224_RS04915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2224_RS04950	COG2226	methyltransferase
K2224_RS04960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K2224_RS04970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K2224_RS04975	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K2224_RS04980	COG1278	Cold shock
K2224_RS05000	COG1309	transcriptional regulator
K2224_RS05005	COG1301	dicarboxylic acid transport
K2224_RS05020	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K2224_RS05030	COG0163	prenyltransferase activity
K2224_RS05040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K2224_RS05045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K2224_RS05070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K2224_RS05075	COG1333	cytochrome c biogenesis protein
K2224_RS05080	COG0785	Cytochrome C biogenesis protein
K2224_RS05095	COG0406	alpha-ribazole phosphatase activity
K2224_RS05100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K2224_RS05135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2224_RS05140	COG1742	UPF0060 membrane protein
K2224_RS05155	COG1690	Belongs to the RtcB family
K2224_RS05175	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K2224_RS05180	COG0018	arginyl-trna synthetase
K2224_RS05190	COG0667	Aldo Keto reductase
K2224_RS05200	COG0113	porphobilinogen synthase activity
K2224_RS05205	COG1648	precorrin-2 dehydrogenase activity
K2224_RS05205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K2224_RS05210	COG0181	hydroxymethylbilane synthase activity
K2224_RS05215	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K2224_RS05220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K2224_RS05270	COG0123	including yeast histone deacetylase and acetoin utilization protein
K2224_RS05280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2224_RS05340	COG0579	oxidoreductase
K2224_RS05345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K2224_RS05390	COG0513	Belongs to the DEAD box helicase family
K2224_RS05430	COG1643	Atp-dependent helicase
K2224_RS05465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K2224_RS05490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K2224_RS05495	COG0047	phosphoribosylformylglycinamidine synthase activity
K2224_RS05500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K2224_RS05525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K2224_RS05535	COG0583	DNA-binding transcription factor activity
K2224_RS05550	COG0151	Belongs to the GarS family
K2224_RS05565	COG1802	Transcriptional regulator
K2224_RS05570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K2224_RS05580	COG0515	serine threonine protein kinase
K2224_RS05580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2224_RS05585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K2224_RS05600	COG1131	(ABC) transporter
K2224_RS05605	COG3559	Exporter of polyketide antibiotics
K2224_RS05610	COG2197	response regulator
K2224_RS05615	COG4585	Histidine kinase
K2224_RS05625	COG3844	kynureninase activity
K2224_RS05630	COG3483	tryptophan 2,3-dioxygenase activity
K2224_RS05640	COG0477	Major facilitator Superfamily
K2224_RS05645	COG0191	fructose-bisphosphate aldolase activity
K2224_RS05650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K2224_RS05665	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K2224_RS05690	COG0542	response to heat
K2224_RS05710	COG0789	Transcriptional regulator
K2224_RS05715	COG0484	heat shock protein binding
K2224_RS05720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K2224_RS05725	COG0443	Heat shock 70 kDa protein
K2224_RS05730	COG0247	lactate metabolic process
K2224_RS05730	COG2181	nitrate reductase activity
K2224_RS05750	COG0717	Belongs to the dCTP deaminase family
K2224_RS05765	COG2267	carboxylic ester hydrolase activity
K2224_RS05770	COG2814	Major facilitator Superfamily
K2224_RS05800	COG0745	RESPONSE REGULATOR receiver
K2224_RS05830	COG2301	Belongs to the HpcH HpaI aldolase family
K2224_RS05835	COG2301	Belongs to the HpcH HpaI aldolase family
K2224_RS05850	COG0662	Cupin 2, conserved barrel domain protein
K2224_RS05920	COG1316	TRANSCRIPTIONal
K2224_RS05965	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K2224_RS06010	COG1174	glycine betaine transport
K2224_RS06015	COG1174	glycine betaine transport
K2224_RS06035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2224_RS06040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K2224_RS06065	COG1960	acyl-CoA dehydrogenase activity
K2224_RS06070	COG1362	aminopeptidase activity
K2224_RS06075	COG3629	intracellular signal transduction
K2224_RS06075	COG3903	Transcriptional regulator
K2224_RS06135	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2224_RS06140	COG0022	dehydrogenase e1 component
K2224_RS06165	COG0515	serine threonine protein kinase
K2224_RS06170	COG0515	serine threonine protein kinase
K2224_RS06190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K2224_RS06220	COG1522	sequence-specific DNA binding
K2224_RS06225	COG1309	transcriptional regulator
K2224_RS06230	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS06255	COG3396	Phenylacetate-CoA oxygenase
K2224_RS06260	COG3460	Phenylacetate-CoA oxygenase
K2224_RS06265	COG3396	Phenylacetate-CoA oxygenase
K2224_RS06270	COG2151	metal-sulfur cluster biosynthetic enzyme
K2224_RS06275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K2224_RS06295	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS06315	COG1733	regulation of RNA biosynthetic process
K2224_RS06320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K2224_RS06330	COG0583	DNA-binding transcription factor activity
K2224_RS06340	COG1716	ATPase activity
K2224_RS06345	COG1716	ATPase activity
K2224_RS06360	COG0768	penicillin binding
K2224_RS06365	COG0515	serine threonine protein kinase
K2224_RS06375	COG3764	Sortase (surface protein transpeptidase)
K2224_RS06380	COG3764	Sortase (surface protein transpeptidase)
K2224_RS06395	COG3764	Sortase (surface protein transpeptidase)
K2224_RS06410	COG0705	Rhomboid family
K2224_RS06425	COG0583	DNA-binding transcription factor activity
K2224_RS06445	COG0515	serine threonine protein kinase
K2224_RS06470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K2224_RS06480	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
K2224_RS06485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K2224_RS06490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K2224_RS06495	COG0592	DNA-directed DNA polymerase activity
K2224_RS06505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K2224_RS06515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K2224_RS06520	COG0706	membrane insertase activity
K2224_RS06530	COG0357	Ribosomal RNA small subunit methyltransferase G
K2224_RS06535	COG1192	Involved in chromosome partitioning
K2224_RS06550	COG3118	belongs to the thioredoxin family
K2224_RS06555	COG0492	ferredoxin-NADP+ reductase activity
K2224_RS06565	COG1595	DNA-templated transcription, initiation
K2224_RS06570	COG0515	serine threonine protein kinase
K2224_RS06570	COG2815	serine threonine protein kinase
K2224_RS06585	COG0617	tRNA 3'-terminal CCA addition
K2224_RS06600	COG1260	myo-inositol-1-phosphate synthase
K2224_RS06610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K2224_RS06635	COG0360	Binds together with S18 to 16S ribosomal RNA
K2224_RS06640	COG0629	single-stranded DNA binding
K2224_RS06645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K2224_RS06650	COG0359	binds to the 23S rRNA
K2224_RS06665	COG0305	Participates in initiation and elongation during chromosome replication
K2224_RS06700	COG1309	transcriptional regulator
K2224_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS06710	COG0789	Transcriptional regulator
K2224_RS06710	COG4978	Transcriptional regulator
K2224_RS06720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K2224_RS06745	COG2814	Major facilitator Superfamily
K2224_RS06780	COG0626	cystathionine gamma-synthase activity
K2224_RS06785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K2224_RS06790	COG1950	PFAM Membrane protein of
K2224_RS06795	COG0662	Cupin 2, conserved barrel domain protein
K2224_RS06820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K2224_RS06835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K2224_RS06840	COG1609	Transcriptional regulator
K2224_RS06845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K2224_RS06855	COG1271	oxidase subunit
K2224_RS06860	COG1294	oxidase, subunit
K2224_RS06865	COG4988	ABC transporter
K2224_RS06880	COG0561	phosphatase activity
K2224_RS06890	COG0501	Belongs to the peptidase M48B family
K2224_RS06900	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
K2224_RS06915	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
K2224_RS06920	COG0789	Transcriptional regulator
K2224_RS06940	COG1131	(ABC) transporter
K2224_RS06960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K2224_RS06965	COG2807	transmembrane transport
K2224_RS06970	COG2186	Transcriptional regulator
K2224_RS07015	COG0561	phosphatase activity
K2224_RS07020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K2224_RS07030	COG2837	iron assimilation
K2224_RS07035	COG2372	response to copper ion
K2224_RS07090	COG0006	proline dipeptidase activity
K2224_RS07110	COG0653	protein targeting
K2224_RS07125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2224_RS07160	COG1595	DNA-templated transcription, initiation
K2224_RS07190	COG2318	DinB family
K2224_RS07195	COG3437	response regulator, receiver
K2224_RS07200	COG2205	protein histidine kinase activity
K2224_RS07200	COG3437	response regulator, receiver
K2224_RS07200	COG3850	Histidine kinase
K2224_RS07200	COG4999	Histidine kinase
K2224_RS07210	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS07215	COG5000	phosphorelay sensor kinase activity
K2224_RS07240	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS07255	COG0431	NADPH-dependent FMN reductase
K2224_RS07260	COG0745	RESPONSE REGULATOR receiver
K2224_RS07265	COG2205	protein histidine kinase activity
K2224_RS07275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K2224_RS07280	COG0477	Major facilitator Superfamily
K2224_RS07320	COG2353	YceI-like domain
K2224_RS07325	COG0477	Major facilitator Superfamily
K2224_RS07350	COG1191	sigma factor activity
K2224_RS07355	COG1191	sigma factor activity
K2224_RS07385	COG0583	DNA-binding transcription factor activity
K2224_RS07395	COG0590	tRNA wobble adenosine to inosine editing
K2224_RS07405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K2224_RS07440	COG0523	cobalamin synthesis protein
K2224_RS07450	COG1064	alcohol dehydrogenase
K2224_RS07480	COG2268	Band 7 protein
K2224_RS07490	COG0477	Major facilitator Superfamily
K2224_RS07515	COG1309	transcriptional regulator
K2224_RS07555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K2224_RS07560	COG1834	amidinotransferase
K2224_RS07570	COG2188	Transcriptional regulator
K2224_RS07580	COG0402	S-adenosylhomocysteine deaminase activity
K2224_RS07600	COG2208	phosphoserine phosphatase activity
K2224_RS07600	COG1366	Belongs to the anti-sigma-factor antagonist family
K2224_RS07600	COG2172	sigma factor antagonist activity
K2224_RS07615	COG1132	(ABC) transporter
K2224_RS07645	COG2188	Transcriptional regulator
K2224_RS07665	COG3403	YqcI/YcgG family
K2224_RS07715	COG2226	methyltransferase
K2224_RS07745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K2224_RS07750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K2224_RS07770	COG1595	DNA-templated transcription, initiation
K2224_RS07800	COG0339	signal peptide processing
K2224_RS07805	COG2319	Wd-40 repeat
K2224_RS07805	COG4249	Peptidase C14 caspase catalytic subunit p20
K2224_RS07815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2224_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS07955	COG1609	Transcriptional regulator
K2224_RS07980	COG1408	metallophosphoesterase
K2224_RS07990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K2224_RS08000	COG0003	Pfam Anion-transporting ATPase
K2224_RS08025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K2224_RS08055	COG2267	carboxylic ester hydrolase activity
K2224_RS08065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K2224_RS08070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K2224_RS08135	COG1111	helicase
K2224_RS08135	COG1205	dead DEAH box helicase
K2224_RS08140	COG1366	Belongs to the anti-sigma-factor antagonist family
K2224_RS08150	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K2224_RS08160	COG2890	protein-(glutamine-N5) methyltransferase activity
K2224_RS08180	COG1754	DNA topoisomerase type I activity
K2224_RS08180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K2224_RS08185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K2224_RS08190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K2224_RS08220	COG0584	glycerophosphoryl diester phosphodiesterase
K2224_RS08225	COG3594	Acyltransferase
K2224_RS08250	COG1309	transcriptional regulator
K2224_RS08255	COG0657	acetylesterase activity
K2224_RS08300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K2224_RS08300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K2224_RS08305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2224_RS08310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K2224_RS08315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K2224_RS08320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K2224_RS08325	COG0254	rRNA binding
K2224_RS08335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K2224_RS08340	COG0640	Transcriptional regulator
K2224_RS08365	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS08370	COG2318	DinB family
K2224_RS08380	COG0076	glutamate decarboxylase activity
K2224_RS08385	COG0655	NAD(P)H dehydrogenase (quinone) activity
K2224_RS08395	COG0789	Transcriptional regulator
K2224_RS08400	COG0393	Putative heavy-metal-binding
K2224_RS08405	COG0586	Pfam SNARE associated Golgi protein
K2224_RS08415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K2224_RS08420	COG2027	D-alanyl-D-alanine carboxypeptidase
K2224_RS08430	COG0037	tRNA processing
K2224_RS08445	COG0302	gtp cyclohydrolase
K2224_RS08470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K2224_RS08475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K2224_RS08485	COG0517	IMP dehydrogenase activity
K2224_RS08485	COG1125	glycine betaine transport
K2224_RS08490	COG1174	glycine betaine transport
K2224_RS08495	COG1174	glycine betaine transport
K2224_RS08510	COG0649	NAD binding
K2224_RS08525	COG2197	response regulator
K2224_RS08535	COG0640	Transcriptional regulator
K2224_RS08545	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K2224_RS08555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K2224_RS08560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K2224_RS08570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K2224_RS08590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K2224_RS08650	COG2205	protein histidine kinase activity
K2224_RS08655	COG0745	RESPONSE REGULATOR receiver
K2224_RS08665	COG1595	DNA-templated transcription, initiation
K2224_RS08670	COG1194	a g-specific adenine glycosylase
K2224_RS08690	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K2224_RS08710	COG0248	Ppx GppA phosphatase
K2224_RS08715	COG1082	Xylose isomerase domain protein TIM barrel
K2224_RS08720	COG0129	dihydroxy-acid dehydratase activity
K2224_RS08780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K2224_RS08830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS08835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS08845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS08905	COG0739	heme binding
K2224_RS08905	COG0741	lytic transglycosylase activity
K2224_RS08905	COG1196	nuclear chromosome segregation
K2224_RS08910	COG0671	phosphoesterase, PA-phosphatase related
K2224_RS08915	COG0277	FAD linked oxidase domain protein
K2224_RS08935	COG1937	Protein conserved in bacteria
K2224_RS08945	COG0306	phosphate transporter
K2224_RS09005	COG0754	glutathionylspermidine amidase activity
K2224_RS09010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K2224_RS09020	COG2890	protein-(glutamine-N5) methyltransferase activity
K2224_RS09035	COG0667	Aldo Keto reductase
K2224_RS09055	COG1733	regulation of RNA biosynthetic process
K2224_RS09060	COG0431	NADPH-dependent FMN reductase
K2224_RS09080	COG1490	D-aminoacyl-tRNA deacylase activity
K2224_RS09100	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K2224_RS09105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K2224_RS09110	COG3485	protocatechuate 3,4-dioxygenase
K2224_RS09130	COG2897	thiosulfate sulfurtransferase activity
K2224_RS09165	COG0745	RESPONSE REGULATOR receiver
K2224_RS09170	COG1609	Transcriptional regulator
K2224_RS09180	COG0745	RESPONSE REGULATOR receiver
K2224_RS09185	COG2205	protein histidine kinase activity
K2224_RS09215	COG0737	Belongs to the 5'-nucleotidase family
K2224_RS09220	COG0456	acetyltransferase
K2224_RS09230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K2224_RS09240	COG0494	nUDIX hydrolase
K2224_RS09240	COG0406	alpha-ribazole phosphatase activity
K2224_RS09255	COG0438	transferase activity, transferring glycosyl groups
K2224_RS09270	COG0588	phosphoglycerate mutase activity
K2224_RS09280	COG5002	protein histidine kinase activity
K2224_RS09295	COG1329	Transcriptional regulator
K2224_RS09300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K2224_RS09305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K2224_RS09310	COG3467	pyridoxamine 5'-phosphate
K2224_RS09315	COG0215	cysteine-tRNA ligase activity
K2224_RS09320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2224_RS09330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K2224_RS09340	COG3842	ATPase activity
K2224_RS09435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K2224_RS09475	COG0463	Glycosyl transferase, family 2
K2224_RS09480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K2224_RS09490	COG1278	Cold shock
K2224_RS09505	COG1263	PTS System
K2224_RS09505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K2224_RS09510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K2224_RS09545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K2224_RS09570	COG3973	AAA domain
K2224_RS09585	COG1061	Type III restriction enzyme res subunit
K2224_RS09590	COG0702	epimerase
K2224_RS09615	COG1960	acyl-CoA dehydrogenase activity
K2224_RS09620	COG1960	acyl-CoA dehydrogenase activity
K2224_RS09630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS09640	COG0583	DNA-binding transcription factor activity
K2224_RS09655	COG1120	ATPase activity
K2224_RS09675	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K2224_RS09680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K2224_RS09690	COG2814	Major facilitator Superfamily
K2224_RS09705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K2224_RS09715	COG2252	PERMEase
K2224_RS09725	COG1846	Transcriptional regulator
K2224_RS09740	COG0667	Aldo Keto reductase
K2224_RS09755	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K2224_RS09770	COG0277	FAD linked oxidase domain protein
K2224_RS09770	COG0247	lactate metabolic process
K2224_RS09775	COG0583	DNA-binding transcription factor activity
K2224_RS09820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K2224_RS09855	COG0259	pyridoxamine-phosphate oxidase activity
K2224_RS09865	COG4821	SIS domain
K2224_RS09875	COG0596	Alpha beta hydrolase
K2224_RS09875	COG2945	thiolester hydrolase activity
K2224_RS09900	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS09910	COG1131	(ABC) transporter
K2224_RS09985	COG0515	serine threonine protein kinase
K2224_RS09985	COG2815	serine threonine protein kinase
K2224_RS10005	COG0519	Catalyzes the synthesis of GMP from XMP
K2224_RS10005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K2224_RS10010	COG2084	Dehydrogenase
K2224_RS10050	COG0515	serine threonine protein kinase
K2224_RS10060	COG2197	response regulator
K2224_RS10105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K2224_RS10120	COG0714	Associated with various cellular activities
K2224_RS10130	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K2224_RS10145	COG0045	succinate-CoA ligase (ADP-forming) activity
K2224_RS10175	COG0138	bifunctional purine biosynthesis protein purh
K2224_RS10190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K2224_RS10200	COG0538	isocitrate dehydrogenase activity
K2224_RS10205	COG0039	L-malate dehydrogenase activity
K2224_RS10240	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS10250	COG4175	Glycine betaine
K2224_RS10250	COG0517	IMP dehydrogenase activity
K2224_RS10285	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K2224_RS10350	COG1295	ribonuclease BN
K2224_RS10360	COG0180	Tryptophanyl-tRNA synthetase
K2224_RS10365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2224_RS10370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K2224_RS10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K2224_RS10385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K2224_RS10390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K2224_RS10425	COG0789	Transcriptional regulator
K2224_RS10430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K2224_RS10445	COG2009	succinate dehydrogenase
K2224_RS10475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K2224_RS10475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K2224_RS10490	COG3265	gluconokinase activity
K2224_RS10510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K2224_RS10520	COG1216	Glycosyl transferase, family 2
K2224_RS10535	COG2089	acid synthase
K2224_RS10545	COG1473	amidohydrolase
K2224_RS10545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K2224_RS10550	COG1744	ABC transporter substrate-binding protein PnrA-like
K2224_RS10555	COG3845	ABC transporter
K2224_RS10560	COG4603	Belongs to the binding-protein-dependent transport system permease family
K2224_RS10565	COG1079	Belongs to the binding-protein-dependent transport system permease family
K2224_RS10585	COG2814	Major facilitator Superfamily
K2224_RS10590	COG0583	DNA-binding transcription factor activity
K2224_RS10600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K2224_RS10625	COG2205	protein histidine kinase activity
K2224_RS10630	COG0745	RESPONSE REGULATOR receiver
K2224_RS10635	COG1595	DNA-templated transcription, initiation
K2224_RS10650	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS10655	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS10690	COG3344	reverse transcriptase
K2224_RS10695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K2224_RS10730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2224_RS10765	COG4770	biotin carboxylase activity
K2224_RS10785	COG0424	maF-like protein
K2224_RS10790	COG0768	penicillin binding
K2224_RS10800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K2224_RS10810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K2224_RS10815	COG1024	Enoyl-CoA hydratase
K2224_RS10825	COG2986	histidine ammonia-lyase
K2224_RS10840	COG1376	ErfK ybiS ycfS ynhG family protein
K2224_RS10855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K2224_RS10885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K2224_RS10900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K2224_RS10910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K2224_RS10945	COG0745	RESPONSE REGULATOR receiver
K2224_RS10970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS10975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS11015	COG0667	Aldo Keto reductase
K2224_RS11045	COG2124	cytochrome p450
K2224_RS11050	COG1819	glycosyl
K2224_RS11090	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K2224_RS11120	COG1331	Highly conserved protein containing a thioredoxin domain
K2224_RS11155	COG1331	Highly conserved protein containing a thioredoxin domain
K2224_RS11170	COG0789	Transcriptional regulator
K2224_RS11185	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
K2224_RS11200	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K2224_RS11215	COG1414	Transcriptional regulator
K2224_RS11220	COG0251	oxidation-reduction process
K2224_RS11225	COG2610	gluconate transmembrane transporter activity
K2224_RS11320	COG0667	Aldo Keto reductase
K2224_RS11325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K2224_RS11330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K2224_RS11345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K2224_RS11350	COG0450	alkyl hydroperoxide reductase
K2224_RS11370	COG1136	(ABC) transporter
K2224_RS11385	COG1136	(ABC) transporter
K2224_RS11400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K2224_RS11415	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS11425	COG0114	fumarate hydratase activity
K2224_RS11445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K2224_RS11445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K2224_RS11470	COG0778	Nitroreductase
K2224_RS11475	COG1722	exodeoxyribonuclease VII activity
K2224_RS11480	COG1570	exodeoxyribonuclease VII activity
K2224_RS11485	COG1113	amino acid transport
K2224_RS11490	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K2224_RS11500	COG0012	GTP binding
K2224_RS11575	COG3903	Transcriptional regulator
K2224_RS11575	COG3629	intracellular signal transduction
K2224_RS11605	COG1473	amidohydrolase
K2224_RS11620	COG0531	amino acid
K2224_RS11650	COG0402	S-adenosylhomocysteine deaminase activity
K2224_RS11660	COG1053	succinate dehydrogenase
K2224_RS11675	COG4166	transmembrane transport
K2224_RS11680	COG1217	gtp-binding protein TYPA
K2224_RS11690	COG0601	transmembrane transport
K2224_RS11695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K2224_RS11700	COG0444	Belongs to the ABC transporter superfamily
K2224_RS11705	COG4608	Belongs to the ABC transporter superfamily
K2224_RS11710	COG4608	Belongs to the ABC transporter superfamily
K2224_RS11715	COG0444	Belongs to the ABC transporter superfamily
K2224_RS11725	COG0747	negative chemotaxis
K2224_RS11730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K2224_RS11750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K2224_RS11765	COG1131	(ABC) transporter
K2224_RS11775	COG4585	Histidine kinase
K2224_RS11780	COG2197	response regulator
K2224_RS11820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2224_RS11825	COG1611	Belongs to the LOG family
K2224_RS11830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K2224_RS11840	COG0519	Catalyzes the synthesis of GMP from XMP
K2224_RS11845	COG1024	Enoyl-CoA hydratase
K2224_RS11855	COG4122	O-methyltransferase activity
K2224_RS11860	COG1595	DNA-templated transcription, initiation
K2224_RS11870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2224_RS11875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2224_RS11910	COG0598	Magnesium transport protein CorA
K2224_RS11930	COG2095	MarC family integral membrane protein
K2224_RS11940	COG1432	Conserved Protein
K2224_RS11980	COG0596	Alpha beta hydrolase
K2224_RS11980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2224_RS12025	COG0210	DNA helicase
K2224_RS12030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2224_RS12070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K2224_RS12115	COG3480	Lon protease (S16) C-terminal proteolytic domain
K2224_RS12125	COG1615	UPF0182 protein
K2224_RS12150	COG0753	catalase activity
K2224_RS12160	COG0483	inositol monophosphate 1-phosphatase activity
K2224_RS12170	COG2076	Multidrug Resistance protein
K2224_RS12180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K2224_RS12190	COG2135	peptidase activity
K2224_RS12200	COG1595	DNA-templated transcription, initiation
K2224_RS12205	COG5662	AntiSigma factor
K2224_RS12225	COG0242	peptide deformylase activity
K2224_RS12230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K2224_RS12265	COG2188	Transcriptional regulator
K2224_RS12270	COG2182	Extracellular solute-binding protein
K2224_RS12275	COG1175	transmembrane transport
K2224_RS12280	COG0395	ABC-type sugar transport system, permease component
K2224_RS12285	COG1472	Belongs to the glycosyl hydrolase 3 family
K2224_RS12290	COG0363	glucosamine-6-phosphate deaminase activity
K2224_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS12300	COG1309	transcriptional regulator
K2224_RS12315	COG1597	lipid kinase activity
K2224_RS12395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K2224_RS12410	COG2066	Belongs to the glutaminase family
K2224_RS12425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2224_RS12440	COG0598	Magnesium transport protein CorA
K2224_RS12445	COG2807	transmembrane transport
K2224_RS12450	COG2186	Transcriptional regulator
K2224_RS12455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K2224_RS12460	COG1993	acr, cog1993
K2224_RS12465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K2224_RS12485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K2224_RS12520	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS12525	COG1126	abc transporter atp-binding protein
K2224_RS12530	COG0765	amino acid transport
K2224_RS12540	COG0281	malic enzyme
K2224_RS12545	COG0604	alcohol dehydrogenase
K2224_RS12575	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2224_RS12575	COG0567	Dehydrogenase, E1 component
K2224_RS12580	COG2205	protein histidine kinase activity
K2224_RS12585	COG0745	RESPONSE REGULATOR receiver
K2224_RS12600	COG1357	PFAM Pentapeptide repeats (8 copies)
K2224_RS12605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K2224_RS12685	COG1119	ATPase activity
K2224_RS12695	COG0768	penicillin binding
K2224_RS12705	COG2124	cytochrome p450
K2224_RS12725	COG0018	arginyl-trna synthetase
K2224_RS12730	COG0019	diaminopimelate decarboxylase activity
K2224_RS12735	COG0460	homoserine dehydrogenase
K2224_RS12740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K2224_RS12745	COG0083	homoserine kinase activity
K2224_RS12760	COG0254	rRNA binding
K2224_RS12765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K2224_RS12770	COG2890	protein-(glutamine-N5) methyltransferase activity
K2224_RS12780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K2224_RS12785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2224_RS12805	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K2224_RS12810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K2224_RS12815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K2224_RS12820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K2224_RS12825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K2224_RS12830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K2224_RS12835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K2224_RS12845	COG2197	response regulator
K2224_RS12850	COG4585	Histidine kinase
K2224_RS12865	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS12880	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
K2224_RS12915	COG1131	(ABC) transporter
K2224_RS12935	COG0183	Belongs to the thiolase family
K2224_RS12995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K2224_RS12995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K2224_RS13000	COG2205	protein histidine kinase activity
K2224_RS13005	COG0745	RESPONSE REGULATOR receiver
K2224_RS13010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K2224_RS13050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K2224_RS13055	COG0857	belongs to the CobB CobQ family
K2224_RS13055	COG0280	phosphate acetyltransferase
K2224_RS13060	COG0205	6-phosphofructokinase activity
K2224_RS13070	COG0577	efflux transmembrane transporter activity
K2224_RS13075	COG1136	(ABC) transporter
K2224_RS13075	COG0577	efflux transmembrane transporter activity
K2224_RS13095	COG4565	transcriptional regulatory protein
K2224_RS13100	COG3290	protein histidine kinase activity
K2224_RS13105	COG1301	dicarboxylic acid transport
K2224_RS13110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K2224_RS13120	COG0366	Alpha amylase catalytic
K2224_RS13125	COG0366	Alpha amylase catalytic
K2224_RS13145	COG1132	(ABC) transporter
K2224_RS13150	COG1132	(ABC) transporter
K2224_RS13165	COG1376	ErfK ybiS ycfS ynhG family protein
K2224_RS13185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K2224_RS13185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K2224_RS13190	COG0785	Cytochrome C biogenesis protein
K2224_RS13200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K2224_RS13205	COG3757	hydrolase, family 25
K2224_RS13205	COG3409	Peptidoglycan-binding domain 1 protein
K2224_RS13210	COG0438	transferase activity, transferring glycosyl groups
K2224_RS13235	COG0586	Pfam SNARE associated Golgi protein
K2224_RS13240	COG0671	phosphoesterase, PA-phosphatase related
K2224_RS13255	COG1760	l-serine dehydratase
K2224_RS13260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2224_RS13265	COG0509	glycine decarboxylation via glycine cleavage system
K2224_RS13270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K2224_RS13275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K2224_RS13305	COG0444	Belongs to the ABC transporter superfamily
K2224_RS13310	COG4608	Belongs to the ABC transporter superfamily
K2224_RS13320	COG2860	membrane
K2224_RS13345	COG0482	sulfurtransferase activity
K2224_RS13355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K2224_RS13360	COG1611	Belongs to the LOG family
K2224_RS13365	COG4221	oxidoreductase activity
K2224_RS13375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K2224_RS13385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K2224_RS13390	COG0154	amidase activity
K2224_RS13400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K2224_RS13435	COG2409	Drug exporters of the RND superfamily
K2224_RS13450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K2224_RS13450	COG1672	PFAM Archaeal ATPase
K2224_RS13460	COG2133	pyrroloquinoline quinone binding
K2224_RS13465	COG0667	Aldo Keto reductase
K2224_RS13475	COG3300	MHYT domain
K2224_RS13475	COG5001	Diguanylate cyclase
K2224_RS13485	COG0440	acetolactate synthase activity
K2224_RS13490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K2224_RS13495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K2224_RS13510	COG3835	regulator
K2224_RS13515	COG0506	proline dehydrogenase activity
K2224_RS13520	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS13525	COG0473	3-isopropylmalate dehydrogenase activity
K2224_RS13530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K2224_RS13540	COG0832	Belongs to the urease beta subunit family
K2224_RS13540	COG0831	urea catabolic process
K2224_RS13545	COG0804	urea catabolic process
K2224_RS13550	COG2957	Belongs to the agmatine deiminase family
K2224_RS13555	COG1309	transcriptional regulator
K2224_RS13560	COG0477	Major facilitator Superfamily
K2224_RS13565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K2224_RS13570	COG5492	domain, Protein
K2224_RS13575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K2224_RS13610	COG2018	Roadblock/LC7 domain
K2224_RS13630	COG2018	Roadblock/LC7 domain
K2224_RS13645	COG0179	Fumarylacetoacetate (FAA) hydrolase
K2224_RS13650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K2224_RS13685	COG1414	Transcriptional regulator
K2224_RS13690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K2224_RS13695	COG0066	3-isopropylmalate dehydratase activity
K2224_RS13705	COG0776	regulation of translation
K2224_RS13715	COG1920	GTP binding
K2224_RS13725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K2224_RS13730	COG1181	Belongs to the D-alanine--D-alanine ligase family
K2224_RS13750	COG0351	phosphomethylpyrimidine kinase
K2224_RS13755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K2224_RS13760	COG1461	Dihydroxyacetone kinase
K2224_RS13770	COG0742	ribosomal rna small subunit methyltransferase
K2224_RS13775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K2224_RS13790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K2224_RS13795	COG0571	ribonuclease III activity
K2224_RS13800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K2224_RS13810	COG1254	Belongs to the acylphosphatase family
K2224_RS13825	COG0477	Major facilitator Superfamily
K2224_RS13840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K2224_RS13875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K2224_RS13895	COG0228	four-way junction DNA binding
K2224_RS13900	COG1837	Belongs to the UPF0109 family
K2224_RS13905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K2224_RS13910	COG0336	Belongs to the RNA methyltransferase TrmD family
K2224_RS13915	COG0335	large ribosomal subunit rRNA binding
K2224_RS13920	COG0681	Belongs to the peptidase S26 family
K2224_RS13925	COG0681	Belongs to the peptidase S26 family
K2224_RS13930	COG0681	Belongs to the peptidase S26 family
K2224_RS13935	COG0681	Belongs to the peptidase S26 family
K2224_RS13965	COG1191	sigma factor activity
K2224_RS13980	COG0052	Belongs to the universal ribosomal protein uS2 family
K2224_RS13985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K2224_RS13990	COG0528	UMP kinase activity
K2224_RS13995	COG0233	cytoplasmic translational termination
K2224_RS14005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K2224_RS14015	COG4208	sulfate ABC transporter
K2224_RS14020	COG3842	ATPase activity
K2224_RS14025	COG2197	response regulator
K2224_RS14030	COG4585	Histidine kinase
K2224_RS14065	COG4181	ATPase activity
K2224_RS14070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K2224_RS14080	COG0419	ATPase involved in DNA repair
K2224_RS14085	COG0420	3'-5' exonuclease activity
K2224_RS14100	COG3209	COG3209 Rhs family protein
K2224_RS14120	COG1309	transcriptional regulator
K2224_RS14135	COG4865	methylaspartate mutase activity
K2224_RS14165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS14190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K2224_RS14210	COG3629	intracellular signal transduction
K2224_RS14400	COG0789	Transcriptional regulator
K2224_RS14555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K2224_RS14615	COG3344	reverse transcriptase
K2224_RS14650	COG0477	Major facilitator Superfamily
K2224_RS14700	COG2226	methyltransferase
K2224_RS14710	COG3979	chitinase
K2224_RS14765	COG0492	ferredoxin-NADP+ reductase activity
K2224_RS14805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2224_RS14810	COG0805	protein transport
K2224_RS14840	COG0688	phosphatidylethanolamine metabolic process
K2224_RS14850	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS14880	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS14900	COG0640	Transcriptional regulator
K2224_RS14935	COG2205	protein histidine kinase activity
K2224_RS14940	COG0745	RESPONSE REGULATOR receiver
K2224_RS14955	COG0154	amidase activity
K2224_RS14970	COG4977	sequence-specific DNA binding
K2224_RS15045	COG2124	cytochrome p450
K2224_RS15085	COG0583	DNA-binding transcription factor activity
K2224_RS15090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2224_RS15110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K2224_RS15130	COG1169	isochorismate synthase
K2224_RS15170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS15185	COG2197	response regulator
K2224_RS15190	COG0604	alcohol dehydrogenase
K2224_RS15220	COG1231	oxidoreductase activity
K2224_RS15235	COG2018	Roadblock/LC7 domain
K2224_RS15245	COG2223	nitrite transmembrane transporter activity
K2224_RS15255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K2224_RS15410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K2224_RS15455	COG0657	acetylesterase activity
K2224_RS15460	COG0667	Aldo Keto reductase
K2224_RS15485	COG0667	Aldo Keto reductase
K2224_RS15495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K2224_RS15500	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K2224_RS15505	COG1120	ATPase activity
K2224_RS15510	COG4607	ABC-type enterochelin transport system periplasmic component
K2224_RS15515	COG0174	glutamine synthetase
K2224_RS15550	COG0019	diaminopimelate decarboxylase activity
K2224_RS15575	COG0477	Major facilitator Superfamily
K2224_RS15605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS15610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS15670	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS15670	COG3321	synthase
K2224_RS15670	COG0604	alcohol dehydrogenase
K2224_RS15680	COG1129	ABC transporter
K2224_RS15695	COG1132	(ABC) transporter
K2224_RS15700	COG1132	(ABC) transporter
K2224_RS15700	COG2375	cellular response to nickel ion
K2224_RS15720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS15720	COG2226	methyltransferase
K2224_RS15720	COG3433	isochorismatase activity
K2224_RS15725	COG2226	methyltransferase
K2224_RS15725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS15725	COG3433	isochorismatase activity
K2224_RS15755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2224_RS15765	COG2409	Drug exporters of the RND superfamily
K2224_RS15775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K2224_RS15780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K2224_RS15780	COG2070	2-Nitropropane dioxygenase
K2224_RS15805	COG0626	cystathionine gamma-synthase activity
K2224_RS15810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K2224_RS15850	COG3903	Transcriptional regulator
K2224_RS15850	COG3629	intracellular signal transduction
K2224_RS15910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K2224_RS15915	COG1120	ATPase activity
K2224_RS15925	COG0477	Major facilitator Superfamily
K2224_RS15930	COG0367	asparagine synthase
K2224_RS16000	COG1846	Transcriptional regulator
K2224_RS16015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2224_RS16020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2224_RS16040	COG0596	Alpha beta hydrolase
K2224_RS16045	COG1802	Transcriptional regulator
K2224_RS16050	COG0285	dihydrofolate synthase activity
K2224_RS16070	COG0640	Transcriptional regulator
K2224_RS16080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2224_RS16095	COG0202	RNA polymerase activity
K2224_RS16110	COG4221	oxidoreductase activity
K2224_RS16195	COG0517	IMP dehydrogenase activity
K2224_RS16195	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K2224_RS16200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K2224_RS16235	COG2814	Major facilitator Superfamily
K2224_RS16250	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS16255	COG4608	Belongs to the ABC transporter superfamily
K2224_RS16265	COG0601	transmembrane transport
K2224_RS16270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K2224_RS16275	COG0747	negative chemotaxis
K2224_RS16280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2224_RS16300	COG3938	Belongs to the proline racemase family
K2224_RS16310	COG1802	Transcriptional regulator
K2224_RS16330	COG1136	(ABC) transporter
K2224_RS16330	COG0577	efflux transmembrane transporter activity
K2224_RS16335	COG0577	efflux transmembrane transporter activity
K2224_RS16335	COG1136	(ABC) transporter
K2224_RS16340	COG2197	response regulator
K2224_RS16345	COG4585	Histidine kinase
K2224_RS16385	COG0148	phosphopyruvate hydratase activity
K2224_RS16400	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS16410	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS16435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2224_RS16440	COG1280	lysine exporter protein (LysE YggA)
K2224_RS16450	COG0515	serine threonine protein kinase
K2224_RS16450	COG2815	serine threonine protein kinase
K2224_RS16460	COG3186	Phenylalanine-4-hydroxylase
K2224_RS16475	COG1231	oxidoreductase activity
K2224_RS16485	COG2192	nodulation
K2224_RS16495	COG1309	transcriptional regulator
K2224_RS16530	COG0651	ATP synthesis coupled electron transport
K2224_RS16565	COG1573	uracil-dna glycosylase
K2224_RS16605	COG3842	ATPase activity
K2224_RS16645	COG2124	cytochrome p450
K2224_RS16665	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K2224_RS16670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K2224_RS16675	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K2224_RS16685	COG0531	amino acid
K2224_RS16690	COG0025	NhaP-type Na H and K H
K2224_RS16715	COG2814	Major facilitator Superfamily
K2224_RS16720	COG1309	transcriptional regulator
K2224_RS16740	COG1473	amidohydrolase
K2224_RS16770	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS16790	COG1846	Transcriptional regulator
K2224_RS16795	COG0438	transferase activity, transferring glycosyl groups
K2224_RS16810	COG2824	Alkylphosphonate utilization operon protein PhnA
K2224_RS16820	COG0659	secondary active sulfate transmembrane transporter activity
K2224_RS16900	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS16915	COG0494	nUDIX hydrolase
K2224_RS16920	COG0590	tRNA wobble adenosine to inosine editing
K2224_RS16935	COG0583	DNA-binding transcription factor activity
K2224_RS16940	COG0596	Alpha beta hydrolase
K2224_RS16955	COG2945	thiolester hydrolase activity
K2224_RS16955	COG0596	Alpha beta hydrolase
K2224_RS17080	COG0535	radical SAM domain protein
K2224_RS17105	COG3629	intracellular signal transduction
K2224_RS17105	COG3903	Transcriptional regulator
K2224_RS17110	COG2770	Histidine kinase
K2224_RS17110	COG2208	phosphoserine phosphatase activity
K2224_RS17155	COG1733	regulation of RNA biosynthetic process
K2224_RS17175	COG0789	Transcriptional regulator
K2224_RS17240	COG0275	rRNA processing
K2224_RS17250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K2224_RS17275	COG0535	radical SAM domain protein
K2224_RS17285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2224_RS17320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS17330	COG1051	belongs to the nudix hydrolase family
K2224_RS17360	COG1476	TRANSCRIPTIONal
K2224_RS17390	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K2224_RS17395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K2224_RS17420	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS17460	COG0640	Transcriptional regulator
K2224_RS17485	COG1116	anion transmembrane transporter activity
K2224_RS17490	COG0640	Transcriptional regulator
K2224_RS17495	COG0739	heme binding
K2224_RS17495	COG0741	lytic transglycosylase activity
K2224_RS17495	COG1196	nuclear chromosome segregation
K2224_RS17500	COG2239	Acts as a magnesium transporter
K2224_RS17505	COG1914	H( )-stimulated, divalent metal cation uptake system
K2224_RS17550	COG2175	clavaminate synthase activity
K2224_RS17565	COG3963	phosphatidate phosphatase activity
K2224_RS17595	COG0456	acetyltransferase
K2224_RS17595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K2224_RS17635	COG1309	transcriptional regulator
K2224_RS17640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K2224_RS17645	COG2205	protein histidine kinase activity
K2224_RS17685	COG3511	phospholipase C
K2224_RS17690	COG2186	Transcriptional regulator
K2224_RS17695	COG1879	ABC-type sugar transport system periplasmic component
K2224_RS17700	COG1129	ABC transporter
K2224_RS17710	COG4948	Mandelate Racemase Muconate Lactonizing
K2224_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS17750	COG0640	Transcriptional regulator
K2224_RS17790	COG2169	Transcriptional regulator
K2224_RS17790	COG1917	Cupin 2, conserved barrel domain protein
K2224_RS17795	COG2986	histidine ammonia-lyase
K2224_RS17805	COG2084	Dehydrogenase
K2224_RS17815	COG3321	synthase
K2224_RS17815	COG0604	alcohol dehydrogenase
K2224_RS17880	COG1960	acyl-CoA dehydrogenase activity
K2224_RS17920	COG0604	alcohol dehydrogenase
K2224_RS17920	COG3321	synthase
K2224_RS17935	COG4585	Histidine kinase
K2224_RS17940	COG2197	response regulator
K2224_RS17970	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K2224_RS17975	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K2224_RS17980	COG0235	Class ii aldolase
K2224_RS17980	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K2224_RS17985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K2224_RS17990	COG0235	Class ii aldolase
K2224_RS17990	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K2224_RS18015	COG0596	Alpha beta hydrolase
K2224_RS18035	COG3795	YCII-related domain
K2224_RS18040	COG0154	amidase activity
K2224_RS18075	COG0583	DNA-binding transcription factor activity
K2224_RS18110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K2224_RS18135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K2224_RS18170	COG2226	methyltransferase
K2224_RS18175	COG0477	Major facilitator Superfamily
K2224_RS18225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K2224_RS18230	COG1937	Protein conserved in bacteria
K2224_RS18235	COG0730	response to heat
K2224_RS18245	COG0583	DNA-binding transcription factor activity
K2224_RS18250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K2224_RS18255	COG1024	Enoyl-CoA hydratase
K2224_RS18265	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS18270	COG1960	acyl-CoA dehydrogenase activity
K2224_RS18295	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS18315	COG0346	lactoylglutathione lyase activity
K2224_RS18320	COG0583	DNA-binding transcription factor activity
K2224_RS18330	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS18375	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS18400	COG2814	Major facilitator Superfamily
K2224_RS18405	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K2224_RS18430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS18435	COG1595	DNA-templated transcription, initiation
K2224_RS18440	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS18510	COG0667	Aldo Keto reductase
K2224_RS18520	COG1132	(ABC) transporter
K2224_RS18540	COG0393	Putative heavy-metal-binding
K2224_RS18595	COG0745	RESPONSE REGULATOR receiver
K2224_RS18610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K2224_RS18630	COG1846	Transcriptional regulator
K2224_RS18650	COG2159	amidohydrolase
K2224_RS18655	COG1846	Transcriptional regulator
K2224_RS18695	COG3340	Belongs to the peptidase S51 family
K2224_RS18710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS18720	COG0640	Transcriptional regulator
K2224_RS18775	COG5006	permease, DMT superfamily
K2224_RS18785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K2224_RS18805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K2224_RS18815	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K2224_RS18850	COG1404	Belongs to the peptidase S8 family
K2224_RS18910	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS18940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K2224_RS18945	COG3485	protocatechuate 3,4-dioxygenase
K2224_RS18990	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS19005	COG2197	response regulator
K2224_RS19015	COG1073	alpha beta
K2224_RS19060	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS19070	COG0488	(ABC) transporter
K2224_RS19080	COG2318	DinB family
K2224_RS19085	COG0326	Molecular chaperone. Has ATPase activity
K2224_RS19095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K2224_RS19100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K2224_RS19105	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K2224_RS19110	COG0110	maltose O-acetyltransferase activity
K2224_RS19145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K2224_RS19175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K2224_RS19185	COG1473	amidohydrolase
K2224_RS19190	COG0596	Alpha beta hydrolase
K2224_RS19235	COG2124	cytochrome p450
K2224_RS19260	COG1254	Belongs to the acylphosphatase family
K2224_RS19295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K2224_RS19330	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS19350	COG1309	transcriptional regulator
K2224_RS19365	COG0583	DNA-binding transcription factor activity
K2224_RS19395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2224_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS19405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2224_RS19415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS19430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2224_RS19450	COG5002	protein histidine kinase activity
K2224_RS19490	COG2132	Multicopper oxidase
K2224_RS19515	COG0738	Major facilitator superfamily
K2224_RS19545	COG0583	DNA-binding transcription factor activity
K2224_RS19550	COG0473	3-isopropylmalate dehydrogenase activity
K2224_RS19565	COG2223	nitrite transmembrane transporter activity
K2224_RS19575	COG2124	cytochrome p450
K2224_RS19585	COG3850	Histidine kinase
K2224_RS19605	COG1191	sigma factor activity
K2224_RS19610	COG1819	glycosyl
K2224_RS19650	COG2264	protein methyltransferase activity
K2224_RS19685	COG1959	2 iron, 2 sulfur cluster binding
K2224_RS19690	COG1017	nitric oxide dioxygenase activity
K2224_RS19690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K2224_RS19735	COG2080	2 iron, 2 sulfur cluster binding
K2224_RS19740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K2224_RS19745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K2224_RS19770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K2224_RS19780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K2224_RS19795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2224_RS19800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS19805	COG2267	carboxylic ester hydrolase activity
K2224_RS19825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K2224_RS19835	COG1960	acyl-CoA dehydrogenase activity
K2224_RS19850	COG3387	PFAM Glycoside hydrolase 15-related
K2224_RS19855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K2224_RS19890	COG4221	oxidoreductase activity
K2224_RS19965	COG0181	hydroxymethylbilane synthase activity
K2224_RS20005	COG1794	racemase activity, acting on amino acids and derivatives
K2224_RS20040	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS20060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K2224_RS20070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K2224_RS20090	COG0367	asparagine synthase
K2224_RS20125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K2224_RS20140	COG4310	Domain of unknown function (DUF2172)
K2224_RS20150	COG1215	transferase activity, transferring glycosyl groups
K2224_RS20160	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K2224_RS20165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K2224_RS20190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K2224_RS20200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K2224_RS20210	COG0583	DNA-binding transcription factor activity
K2224_RS20235	COG1316	TRANSCRIPTIONal
K2224_RS20240	COG1442	glycosyl transferase family 8
K2224_RS20240	COG1216	Glycosyl transferase, family 2
K2224_RS20265	COG2197	response regulator
K2224_RS20275	COG4195	phage-related replication protein
K2224_RS20295	COG0154	amidase activity
K2224_RS20300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2224_RS20305	COG1309	transcriptional regulator
K2224_RS20335	COG1309	transcriptional regulator
K2224_RS20365	COG3903	Transcriptional regulator
K2224_RS20365	COG3629	intracellular signal transduction
K2224_RS20440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K2224_RS20445	COG1136	(ABC) transporter
K2224_RS20455	COG4585	Histidine kinase
K2224_RS20460	COG2197	response regulator
K2224_RS20505	COG0483	inositol monophosphate 1-phosphatase activity
K2224_RS20520	COG3979	chitinase
K2224_RS20525	COG1472	Belongs to the glycosyl hydrolase 3 family
K2224_RS20545	COG2124	cytochrome p450
K2224_RS20580	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS20585	COG0300	oxidoreductase activity
K2224_RS20590	COG0189	ligase activity
K2224_RS20610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS20620	COG0583	DNA-binding transcription factor activity
K2224_RS20705	COG0542	response to heat
K2224_RS20750	COG1864	DNA RNA non-specific endonuclease
K2224_RS20750	COG3591	Belongs to the peptidase S1B family
K2224_RS20770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K2224_RS20780	COG3290	protein histidine kinase activity
K2224_RS20785	COG4565	transcriptional regulatory protein
K2224_RS20795	COG0583	DNA-binding transcription factor activity
K2224_RS20810	COG0076	glutamate decarboxylase activity
K2224_RS20830	COG2186	Transcriptional regulator
K2224_RS20860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2224_RS20895	COG0529	Catalyzes the synthesis of activated sulfate
K2224_RS20945	COG0494	nUDIX hydrolase
K2224_RS20980	COG0531	amino acid
K2224_RS21010	COG0076	glutamate decarboxylase activity
K2224_RS21055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K2224_RS21135	COG2274	protein secretion by the type I secretion system
K2224_RS21150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K2224_RS21150	COG1796	DNA polymerase
K2224_RS21155	COG0583	DNA-binding transcription factor activity
K2224_RS21160	COG0156	8-amino-7-oxononanoate synthase activity
K2224_RS21165	COG1063	alcohol dehydrogenase
K2224_RS21185	COG2318	DinB family
K2224_RS21205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2224_RS21220	COG1687	branched-chain amino acid
K2224_RS21260	COG0745	RESPONSE REGULATOR receiver
K2224_RS21265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K2224_RS21265	COG1024	Enoyl-CoA hydratase
K2224_RS21295	COG0659	secondary active sulfate transmembrane transporter activity
K2224_RS21310	COG3585	molybdate ion transport
K2224_RS21320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K2224_RS21320	COG2080	2 iron, 2 sulfur cluster binding
K2224_RS21325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K2224_RS21330	COG3835	regulator
K2224_RS21385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K2224_RS21410	COG0438	transferase activity, transferring glycosyl groups
K2224_RS21450	COG2226	methyltransferase
K2224_RS21465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS21470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS21495	COG0386	Belongs to the glutathione peroxidase family
K2224_RS21510	COG1132	(ABC) transporter
K2224_RS21540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K2224_RS21590	COG1846	Transcriptional regulator
K2224_RS21625	COG4946	Tricorn protease homolog
K2224_RS21625	COG1506	peptidase
K2224_RS21625	COG0823	Involved in the tonB-independent uptake of proteins
K2224_RS21640	COG1309	transcriptional regulator
K2224_RS21670	COG0477	Major facilitator Superfamily
K2224_RS21685	COG0640	Transcriptional regulator
K2224_RS21695	COG2843	Capsule synthesis protein
K2224_RS21700	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS21720	COG0667	Aldo Keto reductase
K2224_RS21730	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS21760	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS21765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K2224_RS21765	COG0825	malonyl-CoA metabolic process
K2224_RS21775	COG0697	spore germination
K2224_RS21830	COG1695	Transcriptional regulator
K2224_RS21865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K2224_RS21865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K2224_RS21875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K2224_RS21915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K2224_RS21945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K2224_RS21955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K2224_RS21965	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K2224_RS21975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K2224_RS21985	COG2267	carboxylic ester hydrolase activity
K2224_RS22010	COG1414	Transcriptional regulator
K2224_RS22030	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K2224_RS22050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K2224_RS22055	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K2224_RS22060	COG1984	allophanate hydrolase subunit 2
K2224_RS22080	COG0438	transferase activity, transferring glycosyl groups
K2224_RS22085	COG0438	transferase activity, transferring glycosyl groups
K2224_RS22135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS22135	COG0604	alcohol dehydrogenase
K2224_RS22135	COG4221	oxidoreductase activity
K2224_RS22135	COG3321	synthase
K2224_RS22145	COG2345	Transcriptional regulator
K2224_RS22160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K2224_RS22165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS22170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS22175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS22180	COG1960	acyl-CoA dehydrogenase activity
K2224_RS22200	COG3629	intracellular signal transduction
K2224_RS22230	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS22255	COG1024	Enoyl-CoA hydratase
K2224_RS22270	COG1605	Chorismate mutase
K2224_RS22290	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS22300	COG2070	2-Nitropropane dioxygenase
K2224_RS22315	COG0515	serine threonine protein kinase
K2224_RS22325	COG1960	acyl-CoA dehydrogenase activity
K2224_RS22355	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
K2224_RS22360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K2224_RS22390	COG0587	DNA-directed DNA polymerase activity
K2224_RS22425	COG4585	Histidine kinase
K2224_RS22430	COG2197	response regulator
K2224_RS22450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K2224_RS22455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K2224_RS22510	COG0463	Glycosyl transferase, family 2
K2224_RS22525	COG2376	Dihydroxyacetone kinase
K2224_RS22530	COG1461	Dihydroxyacetone kinase
K2224_RS22555	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS22570	COG0583	DNA-binding transcription factor activity
K2224_RS22585	COG1793	dna ligase
K2224_RS22635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K2224_RS22640	COG0463	Glycosyl transferase, family 2
K2224_RS22650	COG0633	Ferredoxin
K2224_RS22650	COG3217	Mosc domain protein beta barrel domain protein
K2224_RS22670	COG0464	growth
K2224_RS22680	COG1349	DNA-binding transcription factor activity
K2224_RS22720	COG1940	carbohydrate kinase activity
K2224_RS22725	COG2223	nitrite transmembrane transporter activity
K2224_RS22735	COG2197	response regulator
K2224_RS22740	COG4585	Histidine kinase
K2224_RS22745	COG0445	tRNA wobble uridine modification
K2224_RS22755	COG0494	nUDIX hydrolase
K2224_RS22780	COG2318	DinB family
K2224_RS22785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K2224_RS22830	COG0584	glycerophosphoryl diester phosphodiesterase
K2224_RS22880	COG3103	Sh3 type 3 domain protein
K2224_RS22880	COG1388	LysM domain
K2224_RS22880	COG0791	NLP P60 protein
K2224_RS22980	COG0667	Aldo Keto reductase
K2224_RS23020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K2224_RS23025	COG0140	phosphoribosyl-ATP diphosphatase activity
K2224_RS23030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K2224_RS23035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K2224_RS23035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K2224_RS23040	COG3201	nicotinamide mononucleotide transporter
K2224_RS23055	COG0702	epimerase
K2224_RS23060	COG1940	carbohydrate kinase activity
K2224_RS23060	COG1846	Transcriptional regulator
K2224_RS23065	COG0738	Major facilitator superfamily
K2224_RS23075	COG2233	PERMEase
K2224_RS23085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS23095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K2224_RS23110	COG0531	amino acid
K2224_RS23130	COG2390	Transcriptional regulator
K2224_RS23135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K2224_RS23140	COG2838	Isocitrate dehydrogenase
K2224_RS23155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K2224_RS23170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K2224_RS23195	COG0284	orotidine-5'-phosphate decarboxylase activity
K2224_RS23200	COG0167	dihydroorotate dehydrogenase activity
K2224_RS23205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K2224_RS23210	COG0505	Belongs to the CarA family
K2224_RS23220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K2224_RS23225	COG0540	Belongs to the ATCase OTCase family
K2224_RS23230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K2224_RS23240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K2224_RS23245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K2224_RS23250	COG0006	proline dipeptidase activity
K2224_RS23260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K2224_RS23265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K2224_RS23270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K2224_RS23275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K2224_RS23280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K2224_RS23290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K2224_RS23295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K2224_RS23310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K2224_RS23330	COG0124	histidyl-tRNA synthetase
K2224_RS23340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K2224_RS23345	COG1196	nuclear chromosome segregation
K2224_RS23350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K2224_RS23355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K2224_RS23360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K2224_RS23365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K2224_RS23375	COG2255	four-way junction helicase activity
K2224_RS23380	COG0632	four-way junction helicase activity
K2224_RS23385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K2224_RS23390	COG0217	transcriptional regulatory protein
K2224_RS23395	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K2224_RS23400	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K2224_RS23410	COG0438	transferase activity, transferring glycosyl groups
K2224_RS23415	COG1560	Kdo2-lipid A biosynthetic process
K2224_RS23420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K2224_RS23450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K2224_RS23465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K2224_RS23510	COG0456	acetyltransferase
K2224_RS23520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K2224_RS23565	COG1648	precorrin-2 dehydrogenase activity
K2224_RS23565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K2224_RS23570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K2224_RS23585	COG1464	Belongs to the NlpA lipoprotein family
K2224_RS23590	COG2011	ABC-type metal ion transport system permease component
K2224_RS23595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K2224_RS23615	COG0584	glycerophosphoryl diester phosphodiesterase
K2224_RS23630	COG0477	Major facilitator Superfamily
K2224_RS23640	COG0165	Argininosuccinate lyase
K2224_RS23645	COG0137	argininosuccinate synthase activity
K2224_RS23665	COG1438	arginine binding
K2224_RS23670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K2224_RS23675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K2224_RS23680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K2224_RS23685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K2224_RS23695	COG1309	transcriptional regulator
K2224_RS23710	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS23730	COG0697	spore germination
K2224_RS23740	COG1649	PFAM Uncharacterised BCR, COG1649
K2224_RS23755	COG1051	belongs to the nudix hydrolase family
K2224_RS23765	COG0072	phenylalanine-tRNA ligase activity
K2224_RS23765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2224_RS23770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K2224_RS23775	COG5002	protein histidine kinase activity
K2224_RS23780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2224_RS23785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K2224_RS23790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K2224_RS23795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K2224_RS23805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K2224_RS23835	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS23840	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS23850	COG2186	Transcriptional regulator
K2224_RS23855	COG0531	amino acid
K2224_RS23860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K2224_RS23875	COG2233	PERMEase
K2224_RS23900	COG4176	ABC-type proline glycine betaine transport system permease component
K2224_RS23905	COG0517	IMP dehydrogenase activity
K2224_RS23905	COG4175	Glycine betaine
K2224_RS23910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K2224_RS23920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS23930	COG0805	protein transport
K2224_RS23935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2224_RS23965	COG0544	peptidyl-prolyl cis-trans isomerase activity
K2224_RS23970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K2224_RS23980	COG1609	Transcriptional regulator
K2224_RS23985	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K2224_RS23990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K2224_RS24005	COG4122	O-methyltransferase activity
K2224_RS24010	COG1222	aaa ATPase
K2224_RS24030	COG0517	IMP dehydrogenase activity
K2224_RS24030	COG1994	Peptidase M50
K2224_RS24040	COG2197	response regulator
K2224_RS24050	COG0747	negative chemotaxis
K2224_RS24055	COG0546	phosphoglycolate phosphatase activity
K2224_RS24060	COG0646	methionine synthase
K2224_RS24060	COG1410	methionine synthase
K2224_RS24065	COG1414	Transcriptional regulator
K2224_RS24070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K2224_RS24075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K2224_RS24080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K2224_RS24090	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS24100	COG0215	cysteine-tRNA ligase activity
K2224_RS24120	COG0598	Magnesium transport protein CorA
K2224_RS24130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS24135	COG0667	Aldo Keto reductase
K2224_RS24165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2224_RS24210	COG0488	(ABC) transporter
K2224_RS24215	COG2124	cytochrome p450
K2224_RS24225	COG0745	RESPONSE REGULATOR receiver
K2224_RS24255	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K2224_RS24270	COG1960	acyl-CoA dehydrogenase activity
K2224_RS24280	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS24290	COG3876	Protein conserved in bacteria
K2224_RS24295	COG0477	Major facilitator Superfamily
K2224_RS24350	COG1960	acyl-CoA dehydrogenase activity
K2224_RS24375	COG1309	transcriptional regulator
K2224_RS24380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K2224_RS24385	COG2188	Transcriptional regulator
K2224_RS24390	COG0477	Major facilitator Superfamily
K2224_RS24390	COG2814	Major facilitator Superfamily
K2224_RS24415	COG3619	membrane
K2224_RS24425	COG1834	amidinotransferase
K2224_RS24430	COG1725	Transcriptional regulator
K2224_RS24435	COG0367	asparagine synthase
K2224_RS24440	COG2226	methyltransferase
K2224_RS24455	COG1522	sequence-specific DNA binding
K2224_RS24460	COG0531	amino acid
K2224_RS24470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K2224_RS24475	COG0587	DNA-directed DNA polymerase activity
K2224_RS24505	COG0330	HflC and HflK could
K2224_RS24520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS24525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K2224_RS24530	COG1126	abc transporter atp-binding protein
K2224_RS24545	COG0765	amino acid transport
K2224_RS24555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K2224_RS24560	COG1799	cell septum assembly
K2224_RS24565	COG1960	acyl-CoA dehydrogenase activity
K2224_RS24570	COG0477	Major facilitator Superfamily
K2224_RS24580	COG0671	phosphoesterase, PA-phosphatase related
K2224_RS24590	COG0789	Transcriptional regulator
K2224_RS24600	COG0438	transferase activity, transferring glycosyl groups
K2224_RS24605	COG3583	domain protein
K2224_RS24620	COG1160	GTP binding
K2224_RS24630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K2224_RS24655	COG1187	pseudouridine synthase activity
K2224_RS24660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K2224_RS24665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K2224_RS24680	COG0686	Belongs to the AlaDH PNT family
K2224_RS24690	COG0494	nUDIX hydrolase
K2224_RS24695	COG0504	CTP synthase activity
K2224_RS24700	COG3387	PFAM Glycoside hydrolase 15-related
K2224_RS24715	COG0438	transferase activity, transferring glycosyl groups
K2224_RS24725	COG0497	DNA recombination
K2224_RS24735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K2224_RS24755	COG1120	ATPase activity
K2224_RS24760	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K2224_RS24765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K2224_RS24780	COG0647	UMP catabolic process
K2224_RS24795	COG3486	L-lysine 6-monooxygenase (NADPH) activity
K2224_RS24835	COG2094	Belongs to the DNA glycosylase MPG family
K2224_RS24845	COG1881	PFAM PEBP family protein
K2224_RS24870	COG1119	ATPase activity
K2224_RS24890	COG2197	response regulator
K2224_RS24910	COG1131	(ABC) transporter
K2224_RS24910	COG1716	ATPase activity
K2224_RS24910	COG0842	Transport permease protein
K2224_RS24915	COG0560	Phosphoserine phosphatase
K2224_RS24915	COG3830	Belongs to the UPF0237 family
K2224_RS24935	COG2186	Transcriptional regulator
K2224_RS24940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K2224_RS24945	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS24960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K2224_RS24975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K2224_RS24980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K2224_RS25015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K2224_RS25030	COG3387	PFAM Glycoside hydrolase 15-related
K2224_RS25060	COG1302	Protein conserved in bacteria
K2224_RS25070	COG1024	Enoyl-CoA hydratase
K2224_RS25080	COG0488	(ABC) transporter
K2224_RS25100	COG0235	Class ii aldolase
K2224_RS25115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K2224_RS25120	COG1492	cobalamin metabolic process
K2224_RS25135	COG1797	cobyrinic acid a,c-diamide synthase activity
K2224_RS25170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K2224_RS25175	COG1917	Cupin 2, conserved barrel domain protein
K2224_RS25185	COG1902	pentaerythritol trinitrate reductase activity
K2224_RS25195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K2224_RS25200	COG2226	methyltransferase
K2224_RS25225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K2224_RS25230	COG2261	transglycosylase associated protein
K2224_RS25240	COG2226	methyltransferase
K2224_RS25265	COG2171	N-acyltransferase activity
K2224_RS25270	COG3226	Transcriptional regulator
K2224_RS25285	COG0822	iron-sulfur transferase activity
K2224_RS25290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K2224_RS25295	COG0396	ATPase activity
K2224_RS25305	COG0719	Fe-S assembly protein
K2224_RS25320	COG1131	(ABC) transporter
K2224_RS25345	COG0109	protoheme IX farnesyltransferase activity
K2224_RS25350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K2224_RS25355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K2224_RS25370	COG0363	glucosamine-6-phosphate deaminase activity
K2224_RS25375	COG0166	Belongs to the GPI family
K2224_RS25390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K2224_RS25395	COG0149	triose-phosphate isomerase activity
K2224_RS25400	COG0126	phosphoglycerate kinase activity
K2224_RS25405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K2224_RS25410	COG1481	regulation of sporulation
K2224_RS25415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K2224_RS25420	COG1660	Displays ATPase and GTPase activities
K2224_RS25425	COG0322	excinuclease ABC activity
K2224_RS25450	COG2814	Major facilitator Superfamily
K2224_RS25455	COG1063	alcohol dehydrogenase
K2224_RS25460	COG1609	Transcriptional regulator
K2224_RS25470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K2224_RS25505	COG0556	nucleotide-excision repair
K2224_RS25510	COG0584	glycerophosphoryl diester phosphodiesterase
K2224_RS25575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K2224_RS25600	COG0237	dephospho-CoA kinase activity
K2224_RS25615	COG0539	negative regulation of cytoplasmic translation
K2224_RS25620	COG2226	methyltransferase
K2224_RS25625	COG1643	Atp-dependent helicase
K2224_RS25690	COG0737	Belongs to the 5'-nucleotidase family
K2224_RS25715	COG1470	cell adhesion involved in biofilm formation
K2224_RS25715	COG0366	Alpha amylase catalytic
K2224_RS25725	COG2197	response regulator
K2224_RS25760	COG0640	Transcriptional regulator
K2224_RS25780	COG0069	glutamate synthase activity
K2224_RS25780	COG0067	glutamate synthase
K2224_RS25780	COG0070	glutamate synthase
K2224_RS25795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K2224_RS25805	COG0159	tryptophan synthase activity
K2224_RS25810	COG0133	tryptophan synthase activity
K2224_RS25815	COG0134	indole-3-glycerol-phosphate synthase activity
K2224_RS25835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K2224_RS25840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K2224_RS25855	COG0583	DNA-binding transcription factor activity
K2224_RS25865	COG1053	succinate dehydrogenase
K2224_RS25870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K2224_RS25875	COG0107	imidazoleglycerol-phosphate synthase activity
K2224_RS25880	COG0251	oxidation-reduction process
K2224_RS25885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K2224_RS25890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K2224_RS25900	COG0131	Imidazoleglycerol-phosphate dehydratase
K2224_RS25905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K2224_RS25910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K2224_RS25925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K2224_RS25945	COG1432	Conserved Protein
K2224_RS25955	COG0587	DNA-directed DNA polymerase activity
K2224_RS26000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K2224_RS26010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K2224_RS26015	COG3599	regulation of cell shape
K2224_RS26025	COG1799	cell septum assembly
K2224_RS26035	COG1496	oxidoreductase activity
K2224_RS26040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K2224_RS26045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K2224_RS26050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K2224_RS26060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K2224_RS26065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K2224_RS26070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K2224_RS26075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K2224_RS26090	COG0275	rRNA processing
K2224_RS26100	COG0714	Associated with various cellular activities
K2224_RS26120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2224_RS26135	COG1309	transcriptional regulator
K2224_RS26145	COG1233	COG1233 Phytoene dehydrogenase and related
K2224_RS26160	COG0352	thiamine-phosphate diphosphorylase activity
K2224_RS26175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2224_RS26175	COG2022	thiamine diphosphate biosynthetic process
K2224_RS26185	COG2022	thiamine diphosphate biosynthetic process
K2224_RS26195	COG0515	serine threonine protein kinase
K2224_RS26195	COG2815	serine threonine protein kinase
K2224_RS26200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K2224_RS26205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K2224_RS26210	COG2193	ferroxidase activity
K2224_RS26220	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K2224_RS26230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2224_RS26235	COG0205	6-phosphofructokinase activity
K2224_RS26240	COG2197	response regulator
K2224_RS26270	COG1940	carbohydrate kinase activity
K2224_RS26280	COG0003	Pfam Anion-transporting ATPase
K2224_RS26300	COG0438	transferase activity, transferring glycosyl groups
K2224_RS26345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K2224_RS26350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K2224_RS26355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K2224_RS26360	COG0723	plastoquinol--plastocyanin reductase activity
K2224_RS26365	COG2010	Cytochrome c
K2224_RS26370	COG1845	cytochrome c oxidase, subunit III
K2224_RS26380	COG1376	ErfK ybiS ycfS ynhG family protein
K2224_RS26390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K2224_RS26395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K2224_RS26405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2224_RS26420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K2224_RS26430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K2224_RS26435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2224_RS26440	COG2197	response regulator
K2224_RS26445	COG4585	Histidine kinase
K2224_RS26480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K2224_RS26485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K2224_RS26485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K2224_RS26495	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K2224_RS26500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K2224_RS26505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K2224_RS26510	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2224_RS26520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K2224_RS26545	COG1090	epimerase
K2224_RS26560	COG0321	lipoyl(octanoyl) transferase activity
K2224_RS26565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K2224_RS26615	COG2226	methyltransferase
K2224_RS26640	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS26655	COG0745	RESPONSE REGULATOR receiver
K2224_RS26675	COG2197	response regulator
K2224_RS26740	COG0366	Alpha amylase catalytic
K2224_RS26745	COG3833	ABC-type maltose transport systems, permease component
K2224_RS26750	COG1175	transmembrane transport
K2224_RS26760	COG0366	Alpha amylase catalytic
K2224_RS26765	COG1609	Transcriptional regulator
K2224_RS26775	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K2224_RS26780	COG0174	glutamine synthetase
K2224_RS26795	COG2132	Multicopper oxidase
K2224_RS26800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K2224_RS26800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K2224_RS26805	COG2814	Major facilitator Superfamily
K2224_RS26815	COG1309	transcriptional regulator
K2224_RS26820	COG0477	Major facilitator Superfamily
K2224_RS26825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K2224_RS26845	COG1994	Peptidase M50
K2224_RS26865	COG1175	transmembrane transport
K2224_RS26875	COG2186	Transcriptional regulator
K2224_RS26880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2224_RS26900	COG5398	heme oxygenase
K2224_RS26935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K2224_RS26940	COG2814	Major facilitator Superfamily
K2224_RS26945	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS27035	COG3963	phosphatidate phosphatase activity
K2224_RS27040	COG4585	Histidine kinase
K2224_RS27045	COG2197	response regulator
K2224_RS27150	COG1169	isochorismate synthase
K2224_RS27175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS27185	COG0736	holo-[acyl-carrier-protein] synthase activity
K2224_RS27215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2224_RS27235	COG2226	methyltransferase
K2224_RS27245	COG0702	epimerase
K2224_RS27255	COG1131	(ABC) transporter
K2224_RS27280	COG2345	Transcriptional regulator
K2224_RS27285	COG0500	methyltransferase
K2224_RS27295	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K2224_RS27315	COG0789	Transcriptional regulator
K2224_RS27325	COG0557	exoribonuclease II activity
K2224_RS27330	COG3022	response to hydroperoxide
K2224_RS27335	COG0800	Aldolase
K2224_RS27350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K2224_RS27355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K2224_RS27370	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS27380	COG2030	dehydratase
K2224_RS27390	COG4585	Histidine kinase
K2224_RS27395	COG2197	response regulator
K2224_RS27405	COG0183	Belongs to the thiolase family
K2224_RS27410	COG1960	acyl-CoA dehydrogenase activity
K2224_RS27420	COG0860	N-Acetylmuramoyl-L-alanine amidase
K2224_RS27430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS27455	COG0438	transferase activity, transferring glycosyl groups
K2224_RS27460	COG1309	transcriptional regulator
K2224_RS27505	COG3845	ABC transporter
K2224_RS27515	COG0183	Belongs to the thiolase family
K2224_RS27520	COG2124	cytochrome p450
K2224_RS27530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K2224_RS27570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2224_RS27600	COG1072	(Pantothenic acid kinase))
K2224_RS27610	COG0596	Alpha beta hydrolase
K2224_RS27615	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K2224_RS27645	COG2186	Transcriptional regulator
K2224_RS27650	COG4948	Mandelate Racemase Muconate Lactonizing
K2224_RS27675	COG1358	cellular component organization or biogenesis
K2224_RS27720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K2224_RS27730	COG0477	Major facilitator Superfamily
K2224_RS27735	COG1309	transcriptional regulator
K2224_RS27750	COG4585	Histidine kinase
K2224_RS27755	COG2197	response regulator
K2224_RS27770	COG0667	Aldo Keto reductase
K2224_RS27775	COG0789	Transcriptional regulator
K2224_RS27800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2224_RS27805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS27810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS27840	COG1309	transcriptional regulator
K2224_RS27850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2224_RS27865	COG1129	ABC transporter
K2224_RS27870	COG1609	Transcriptional regulator
K2224_RS27875	COG1764	response to oxidative stress
K2224_RS27885	COG2130	NADP-dependent
K2224_RS27895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K2224_RS27900	COG0477	Major facilitator Superfamily
K2224_RS27910	COG3973	AAA domain
K2224_RS27935	COG0500	methyltransferase
K2224_RS27940	COG4981	capsule polysaccharide biosynthetic process
K2224_RS27950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2224_RS27970	COG2018	Roadblock/LC7 domain
K2224_RS27990	COG1960	acyl-CoA dehydrogenase activity
K2224_RS27995	COG1228	amidohydrolase
K2224_RS28000	COG2267	carboxylic ester hydrolase activity
K2224_RS28005	COG3958	Transketolase
K2224_RS28010	COG3959	Transketolase, thiamine diphosphate binding domain
K2224_RS28035	COG2124	cytochrome p450
K2224_RS28040	COG1686	Belongs to the peptidase S11 family
K2224_RS28065	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS28070	COG3246	L-lysine catabolic process to acetate
K2224_RS28085	COG0174	glutamine synthetase
K2224_RS28095	COG0477	Major facilitator Superfamily
K2224_RS28115	COG1024	Enoyl-CoA hydratase
K2224_RS28120	COG1960	acyl-CoA dehydrogenase activity
K2224_RS28135	COG1113	amino acid transport
K2224_RS28140	COG2706	6-phosphogluconolactonase activity
K2224_RS28225	COG3537	Alpha-1,2-mannosidase
K2224_RS28230	COG0531	amino acid
K2224_RS28235	COG3360	Dodecin
K2224_RS28275	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K2224_RS28285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2224_RS28290	COG3572	ergothioneine biosynthetic process
K2224_RS28325	COG1960	acyl-CoA dehydrogenase activity
K2224_RS28330	COG1960	acyl-CoA dehydrogenase activity
K2224_RS28365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K2224_RS28370	COG0444	Belongs to the ABC transporter superfamily
K2224_RS28375	COG1124	(ABC) transporter
K2224_RS28385	COG1349	DNA-binding transcription factor activity
K2224_RS28390	COG2814	Major facilitator Superfamily
K2224_RS28400	COG1070	Carbohydrate kinase
K2224_RS28405	COG0588	phosphoglycerate mutase activity
K2224_RS28410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2224_RS28415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K2224_RS28415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K2224_RS28440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS28440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS28445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS28450	COG1070	Carbohydrate kinase
K2224_RS28455	COG3458	cephalosporin-C deacetylase activity
K2224_RS28465	COG2040	homocysteine
K2224_RS28470	COG2353	YceI-like domain
K2224_RS28480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K2224_RS28520	COG2018	Roadblock/LC7 domain
K2224_RS28535	COG1946	Acyl-CoA thioesterase
K2224_RS28550	COG1132	(ABC) transporter
K2224_RS28555	COG1132	(ABC) transporter
K2224_RS28590	COG1132	(ABC) transporter
K2224_RS28600	COG1556	Lactate utilization protein
K2224_RS28605	COG1139	Iron-sulfur cluster binding protein
K2224_RS28610	COG0247	lactate metabolic process
K2224_RS28615	COG0477	Major facilitator Superfamily
K2224_RS28625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K2224_RS28630	COG0492	ferredoxin-NADP+ reductase activity
K2224_RS28635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS28645	COG1116	anion transmembrane transporter activity
K2224_RS28650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K2224_RS28655	COG0432	Pfam Uncharacterised protein family UPF0047
K2224_RS28725	COG0438	transferase activity, transferring glycosyl groups
K2224_RS28730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K2224_RS28780	COG0702	epimerase
K2224_RS28790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K2224_RS28885	COG1136	(ABC) transporter
K2224_RS29015	COG0596	Alpha beta hydrolase
K2224_RS29030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K2224_RS29070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K2224_RS29080	COG2304	oxidoreductase activity
K2224_RS29085	COG3467	pyridoxamine 5'-phosphate
K2224_RS29110	COG1309	transcriptional regulator
K2224_RS29125	COG0789	Transcriptional regulator
K2224_RS29150	COG1309	transcriptional regulator
K2224_RS29190	COG4213	ABC transporter substrate-binding protein
K2224_RS29220	COG2706	6-phosphogluconolactonase activity
K2224_RS29245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K2224_RS29255	COG1902	pentaerythritol trinitrate reductase activity
K2224_RS29275	COG1309	transcriptional regulator
K2224_RS29285	COG2826	transposase and inactivated derivatives, IS30 family
K2224_RS29290	COG1285	pathogenesis
K2224_RS29300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS29310	COG2890	protein-(glutamine-N5) methyltransferase activity
K2224_RS29325	COG0477	Major facilitator Superfamily
K2224_RS29330	COG1957	nucleoside hydrolase
K2224_RS29335	COG1609	Transcriptional regulator
K2224_RS29355	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
K2224_RS29360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2224_RS29375	COG1796	DNA polymerase
K2224_RS29375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K2224_RS29385	COG0596	Alpha beta hydrolase
K2224_RS29390	COG2070	2-Nitropropane dioxygenase
K2224_RS29395	COG0583	DNA-binding transcription factor activity
K2224_RS29405	COG0156	8-amino-7-oxononanoate synthase activity
K2224_RS29410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS29415	COG2409	Drug exporters of the RND superfamily
K2224_RS29420	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS29440	COG1309	transcriptional regulator
K2224_RS29450	COG1960	acyl-CoA dehydrogenase activity
K2224_RS29475	COG1228	amidohydrolase
K2224_RS29485	COG0463	Glycosyl transferase, family 2
K2224_RS29525	COG3012	SEC-C Motif Domain Protein
K2224_RS29535	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K2224_RS29540	COG1793	dna ligase
K2224_RS29540	COG3285	dna ligase
K2224_RS29545	COG2814	Major facilitator Superfamily
K2224_RS29550	COG1686	Belongs to the peptidase S11 family
K2224_RS29555	COG1278	Cold shock
K2224_RS29595	COG0395	ABC-type sugar transport system, permease component
K2224_RS29600	COG1175	transmembrane transport
K2224_RS29610	COG1609	Transcriptional regulator
K2224_RS29625	COG4585	Histidine kinase
K2224_RS29630	COG2197	response regulator
K2224_RS29635	COG0739	heme binding
K2224_RS29665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS29675	COG1846	Transcriptional regulator
K2224_RS29680	COG1764	response to oxidative stress
K2224_RS29685	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS29690	COG2208	phosphoserine phosphatase activity
K2224_RS29690	COG2770	Histidine kinase
K2224_RS29730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K2224_RS29790	COG2124	cytochrome p450
K2224_RS29795	COG2124	cytochrome p450
K2224_RS29810	COG0110	maltose O-acetyltransferase activity
K2224_RS29825	COG1832	CoA-binding protein
K2224_RS29835	COG1739	Uncharacterized protein family UPF0029
K2224_RS29850	COG0531	amino acid
K2224_RS29885	COG0583	DNA-binding transcription factor activity
K2224_RS29890	COG0006	proline dipeptidase activity
K2224_RS29895	COG0420	3'-5' exonuclease activity
K2224_RS29900	COG0419	ATPase involved in DNA repair
K2224_RS29920	COG1522	sequence-specific DNA binding
K2224_RS29940	COG0346	lactoylglutathione lyase activity
K2224_RS29945	COG1595	DNA-templated transcription, initiation
K2224_RS29955	COG2188	Transcriptional regulator
K2224_RS29960	COG1940	carbohydrate kinase activity
K2224_RS29970	COG3663	DNA glycosylase
K2224_RS29975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K2224_RS29985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K2224_RS30055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K2224_RS30060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K2224_RS30065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K2224_RS30090	COG0740	serine-type endopeptidase activity
K2224_RS30105	COG0831	urea catabolic process
K2224_RS30115	COG0804	urea catabolic process
K2224_RS30120	COG0830	nickel cation binding
K2224_RS30125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K2224_RS30130	COG0829	nickel cation binding
K2224_RS30185	COG0205	6-phosphofructokinase activity
K2224_RS30190	COG3442	glutamine amidotransferase
K2224_RS30200	COG0242	peptide deformylase activity
K2224_RS30210	COG1960	acyl-CoA dehydrogenase activity
K2224_RS30225	COG3960	tartronate-semialdehyde synthase activity
K2224_RS30230	COG2084	Dehydrogenase
K2224_RS30250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K2224_RS30255	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS30280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K2224_RS30295	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
K2224_RS30325	COG0375	protein maturation
K2224_RS30330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K2224_RS30340	COG0298	carbon dioxide binding
K2224_RS30350	COG0309	Hydrogenase expression formation protein (HypE)
K2224_RS30370	COG2837	iron assimilation
K2224_RS30390	COG0640	Transcriptional regulator
K2224_RS30395	COG0531	amino acid
K2224_RS30410	COG1793	dna ligase
K2224_RS30425	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS30465	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS30495	COG1960	acyl-CoA dehydrogenase activity
K2224_RS30500	COG1960	acyl-CoA dehydrogenase activity
K2224_RS30505	COG1960	acyl-CoA dehydrogenase activity
K2224_RS30510	COG1024	Enoyl-CoA hydratase
K2224_RS30515	COG1960	acyl-CoA dehydrogenase activity
K2224_RS30525	COG1309	transcriptional regulator
K2224_RS30530	COG0183	Belongs to the thiolase family
K2224_RS30560	COG1024	Enoyl-CoA hydratase
K2224_RS30595	COG3511	phospholipase C
K2224_RS30640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K2224_RS30640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K2224_RS30670	COG2261	transglycosylase associated protein
K2224_RS30685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2224_RS30700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K2224_RS30705	COG0640	Transcriptional regulator
K2224_RS30750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K2224_RS30775	COG2837	iron assimilation
K2224_RS30805	COG2268	Band 7 protein
K2224_RS30810	COG1585	Membrane protein implicated in regulation of membrane protease activity
K2224_RS30815	COG0672	)-iron permease
K2224_RS30820	COG2837	iron assimilation
K2224_RS30845	COG2197	response regulator
K2224_RS30860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K2224_RS30865	COG0443	Heat shock 70 kDa protein
K2224_RS30880	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS30895	COG1073	alpha beta
K2224_RS30905	COG2239	Acts as a magnesium transporter
K2224_RS30935	COG0640	Transcriptional regulator
K2224_RS30940	COG0301	tRNA thio-modification
K2224_RS30945	COG1216	Glycosyl transferase, family 2
K2224_RS30950	COG0488	(ABC) transporter
K2224_RS30955	COG2226	methyltransferase
K2224_RS30960	COG2423	ornithine cyclodeaminase activity
K2224_RS30990	COG0367	asparagine synthase
K2224_RS31000	COG2423	ornithine cyclodeaminase activity
K2224_RS31005	COG3469	chitinase activity
K2224_RS31010	COG0009	L-threonylcarbamoyladenylate synthase
K2224_RS31030	COG2378	regulation of single-species biofilm formation
K2224_RS31035	COG1070	Carbohydrate kinase
K2224_RS31040	COG1063	alcohol dehydrogenase
K2224_RS31050	COG2814	Major facilitator Superfamily
K2224_RS31055	COG1191	sigma factor activity
K2224_RS31085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2224_RS31090	COG2132	Multicopper oxidase
K2224_RS31120	COG2226	methyltransferase
K2224_RS31145	COG1175	transmembrane transport
K2224_RS31150	COG0395	ABC-type sugar transport system, permease component
K2224_RS31260	COG2205	protein histidine kinase activity
K2224_RS31325	COG1309	transcriptional regulator
K2224_RS31330	COG2084	Dehydrogenase
K2224_RS31375	COG0657	acetylesterase activity
K2224_RS31380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K2224_RS31400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K2224_RS31435	COG0504	CTP synthase activity
K2224_RS31495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K2224_RS31520	COG1473	amidohydrolase
K2224_RS31535	COG0242	peptide deformylase activity
K2224_RS31580	COG1309	transcriptional regulator
K2224_RS31665	COG2130	NADP-dependent
K2224_RS31705	COG0604	alcohol dehydrogenase
K2224_RS31705	COG3321	synthase
K2224_RS31730	COG2226	methyltransferase
K2224_RS31750	COG1595	DNA-templated transcription, initiation
K2224_RS31760	COG0789	Transcriptional regulator
K2224_RS31780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2224_RS31785	COG0596	Alpha beta hydrolase
K2224_RS31790	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS31795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K2224_RS31820	COG0477	Major facilitator Superfamily
K2224_RS31890	COG0515	serine threonine protein kinase
K2224_RS31890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2224_RS31900	COG0513	Belongs to the DEAD box helicase family
K2224_RS31905	COG1278	Cold shock
K2224_RS31920	COG2135	peptidase activity
K2224_RS31970	COG0326	Molecular chaperone. Has ATPase activity
K2224_RS31980	COG0477	Major facilitator Superfamily
K2224_RS32000	COG0667	Aldo Keto reductase
K2224_RS32035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K2224_RS32045	COG0583	DNA-binding transcription factor activity
K2224_RS32080	COG4585	Histidine kinase
K2224_RS32085	COG2197	response regulator
K2224_RS32090	COG0577	efflux transmembrane transporter activity
K2224_RS32090	COG1136	(ABC) transporter
K2224_RS32120	COG0243	molybdopterin cofactor binding
K2224_RS32125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS32135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2224_RS32155	COG4941	Belongs to the sigma-70 factor family
K2224_RS32165	COG3795	YCII-related domain
K2224_RS32215	COG2318	DinB family
K2224_RS32240	COG0745	RESPONSE REGULATOR receiver
K2224_RS32250	COG0019	diaminopimelate decarboxylase activity
K2224_RS32270	COG4977	sequence-specific DNA binding
K2224_RS32285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K2224_RS32300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K2224_RS32360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS32400	COG2205	protein histidine kinase activity
K2224_RS32405	COG0745	RESPONSE REGULATOR receiver
K2224_RS32410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K2224_RS32410	COG1017	nitric oxide dioxygenase activity
K2224_RS32430	COG2205	protein histidine kinase activity
K2224_RS32440	COG4181	ATPase activity
K2224_RS32455	COG0488	(ABC) transporter
K2224_RS32475	COG2326	polyphosphate kinase activity
K2224_RS32525	COG1309	transcriptional regulator
K2224_RS32545	COG0596	Alpha beta hydrolase
K2224_RS32555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K2224_RS32560	COG2814	Major facilitator Superfamily
K2224_RS32610	COG0432	Pfam Uncharacterised protein family UPF0047
K2224_RS32650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2224_RS32660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS32685	COG0500	methyltransferase
K2224_RS32710	COG0438	transferase activity, transferring glycosyl groups
K2224_RS32715	COG0297	glycogen (starch) synthase activity
K2224_RS32730	COG0772	Belongs to the SEDS family
K2224_RS32740	COG1131	(ABC) transporter
K2224_RS32760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K2224_RS32770	COG2205	protein histidine kinase activity
K2224_RS32795	COG1172	Belongs to the binding-protein-dependent transport system permease family
K2224_RS32800	COG1129	ABC transporter
K2224_RS32815	COG0531	amino acid
K2224_RS32825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K2224_RS32830	COG0604	alcohol dehydrogenase
K2224_RS32850	COG2207	Transcriptional regulator
K2224_RS32855	COG1960	acyl-CoA dehydrogenase activity
K2224_RS32860	COG1960	acyl-CoA dehydrogenase activity
K2224_RS32870	COG0745	RESPONSE REGULATOR receiver
K2224_RS32875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K2224_RS32885	COG2223	nitrite transmembrane transporter activity
K2224_RS32890	COG1228	amidohydrolase
K2224_RS32895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K2224_RS32950	COG0531	amino acid
K2224_RS32955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K2224_RS32995	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS33015	COG0142	geranyltranstransferase activity
K2224_RS33025	COG1105	Belongs to the carbohydrate kinase PfkB family
K2224_RS33040	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2224_RS33045	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2224_RS33045	COG0022	dehydrogenase e1 component
K2224_RS33050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K2224_RS33055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K2224_RS33065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K2224_RS33075	COG2815	serine threonine protein kinase
K2224_RS33075	COG0515	serine threonine protein kinase
K2224_RS33080	COG2409	Drug exporters of the RND superfamily
K2224_RS33130	COG3291	Pkd domain containing protein
K2224_RS33145	COG1021	2,3-dihydroxybenzoate-AMP ligase
K2224_RS33205	COG0366	Alpha amylase catalytic
K2224_RS33225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K2224_RS33225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K2224_RS33230	COG0515	serine threonine protein kinase
K2224_RS33230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2224_RS33255	COG2252	PERMEase
K2224_RS33280	COG1819	glycosyl
K2224_RS33295	COG1309	transcriptional regulator
K2224_RS33300	COG0596	Alpha beta hydrolase
K2224_RS33335	COG4585	Histidine kinase
K2224_RS33370	COG1819	glycosyl
K2224_RS33380	COG2249	NAD(P)H dehydrogenase (quinone) activity
K2224_RS33415	COG0488	(ABC) transporter
K2224_RS33435	COG0577	efflux transmembrane transporter activity
K2224_RS33435	COG1136	(ABC) transporter
K2224_RS33440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K2224_RS33450	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS33455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K2224_RS33475	COG1595	DNA-templated transcription, initiation
K2224_RS33500	COG0673	inositol 2-dehydrogenase activity
K2224_RS33505	COG0640	Transcriptional regulator
K2224_RS33540	COG1683	Conserved Protein
K2224_RS33545	COG2124	cytochrome p450
K2224_RS33575	COG0730	response to heat
K2224_RS33585	COG3321	synthase
K2224_RS33585	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS33585	COG0604	alcohol dehydrogenase
K2224_RS33590	COG1309	transcriptional regulator
K2224_RS33660	COG0667	Aldo Keto reductase
K2224_RS33745	COG1309	transcriptional regulator
K2224_RS33750	COG0154	amidase activity
K2224_RS33775	COG4221	oxidoreductase activity
K2224_RS33810	COG2124	cytochrome p450
K2224_RS33855	COG2828	Protein conserved in bacteria
K2224_RS33955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2224_RS33980	COG1733	regulation of RNA biosynthetic process
K2224_RS34110	COG3629	intracellular signal transduction
K2224_RS34130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K2224_RS34155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2224_RS34170	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS34185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K2224_RS34205	COG3842	ATPase activity
K2224_RS34210	COG1176	ABC-type spermidine putrescine transport system, permease component I
K2224_RS34215	COG1177	transmembrane transport
K2224_RS34220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2224_RS34245	COG2508	Transcriptional regulator
K2224_RS34250	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS34260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K2224_RS34265	COG0750	zinc metalloprotease
K2224_RS34270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K2224_RS34285	COG0442	prolyl-tRNA aminoacylation
K2224_RS34305	COG0779	Required for maturation of 30S ribosomal subunits
K2224_RS34320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K2224_RS34330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K2224_RS34335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K2224_RS34350	COG0455	bacterial-type flagellum organization
K2224_RS34365	COG3266	domain, Protein
K2224_RS34395	COG1404	Belongs to the peptidase S8 family
K2224_RS34495	COG1674	ftsk spoiiie
K2224_RS34505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K2224_RS34510	COG1185	polyribonucleotide nucleotidyltransferase activity
K2224_RS34515	COG0612	Peptidase, M16
K2224_RS34520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K2224_RS34540	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K2224_RS34545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2224_RS34550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K2224_RS34580	COG2770	Histidine kinase
K2224_RS34580	COG2208	phosphoserine phosphatase activity
K2224_RS34585	COG4999	Histidine kinase
K2224_RS34585	COG2205	protein histidine kinase activity
K2224_RS34585	COG3437	response regulator, receiver
K2224_RS34585	COG3850	Histidine kinase
K2224_RS34595	COG1674	ftsk spoiiie
K2224_RS34605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K2224_RS34615	COG1546	Belongs to the CinA family
K2224_RS34615	COG1058	Belongs to the CinA family
K2224_RS34620	COG1396	sequence-specific DNA binding
K2224_RS34625	COG0783	Belongs to the Dps family
K2224_RS34635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K2224_RS34640	COG1201	RNA secondary structure unwinding
K2224_RS34680	COG0640	Transcriptional regulator
K2224_RS34685	COG1316	TRANSCRIPTIONal
K2224_RS34700	COG0628	permease
K2224_RS34705	COG0477	Major facilitator Superfamily
K2224_RS34720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K2224_RS34730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2224_RS34735	COG0765	amino acid transport
K2224_RS34740	COG0765	amino acid transport
K2224_RS34745	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K2224_RS34750	COG1126	abc transporter atp-binding protein
K2224_RS34760	COG2205	protein histidine kinase activity
K2224_RS34770	COG0583	DNA-binding transcription factor activity
K2224_RS34780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K2224_RS34795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K2224_RS34805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K2224_RS34810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K2224_RS34820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K2224_RS34855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K2224_RS34860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K2224_RS34865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K2224_RS34880	COG3226	Transcriptional regulator
K2224_RS34905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K2224_RS34920	COG0514	ATP-dependent DNA helicase (RecQ)
K2224_RS34930	COG1278	Cold shock
K2224_RS34955	COG2186	Transcriptional regulator
K2224_RS34960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K2224_RS34975	COG0187	DNA topoisomerase II activity
K2224_RS34985	COG4585	Histidine kinase
K2224_RS34990	COG2197	response regulator
K2224_RS35005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K2224_RS35010	COG0612	Peptidase, M16
K2224_RS35020	COG0739	heme binding
K2224_RS35025	COG1802	Transcriptional regulator
K2224_RS35030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2224_RS35050	COG1435	thymidine kinase activity
K2224_RS35085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K2224_RS35090	COG0483	inositol monophosphate 1-phosphatase activity
K2224_RS35100	COG0745	RESPONSE REGULATOR receiver
K2224_RS35105	COG2205	protein histidine kinase activity
K2224_RS35130	COG0756	dUTP diphosphatase activity
K2224_RS35145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K2224_RS35150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K2224_RS35155	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K2224_RS35190	COG0569	domain protein
K2224_RS35200	COG0531	amino acid
K2224_RS35205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K2224_RS35210	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS35225	COG0210	DNA helicase
K2224_RS35235	COG1401	restriction endodeoxyribonuclease activity
K2224_RS35240	COG0443	Heat shock 70 kDa protein
K2224_RS35275	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K2224_RS35285	COG0515	serine threonine protein kinase
K2224_RS35285	COG2815	serine threonine protein kinase
K2224_RS35340	COG3424	synthase
K2224_RS35345	COG2124	cytochrome p450
K2224_RS35360	COG1309	transcriptional regulator
K2224_RS35365	COG1846	Transcriptional regulator
K2224_RS35380	COG1799	cell septum assembly
K2224_RS35410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K2224_RS35415	COG4977	sequence-specific DNA binding
K2224_RS35425	COG2235	arginine
K2224_RS35430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K2224_RS35435	COG0531	amino acid
K2224_RS35440	COG1024	Enoyl-CoA hydratase
K2224_RS35455	COG0546	phosphoglycolate phosphatase activity
K2224_RS35485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K2224_RS35510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K2224_RS35530	COG1653	transport
K2224_RS35535	COG1175	transmembrane transport
K2224_RS35540	COG0395	ABC-type sugar transport system, permease component
K2224_RS35545	COG1940	carbohydrate kinase activity
K2224_RS35550	COG4213	ABC transporter substrate-binding protein
K2224_RS35560	COG4214	carbohydrate transport
K2224_RS35565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K2224_RS35570	COG0531	amino acid
K2224_RS35580	COG1024	Enoyl-CoA hydratase
K2224_RS35580	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS35585	COG0183	Belongs to the thiolase family
K2224_RS35595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K2224_RS35610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K2224_RS35615	COG0446	pyridine nucleotide-disulphide oxidoreductase
K2224_RS35625	COG0183	Belongs to the thiolase family
K2224_RS35630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K2224_RS35635	COG3253	May function as heme-dependent peroxidase
K2224_RS35660	COG1116	anion transmembrane transporter activity
K2224_RS35695	COG1136	(ABC) transporter
K2224_RS35695	COG0577	efflux transmembrane transporter activity
K2224_RS35705	COG4585	Histidine kinase
K2224_RS35710	COG2197	response regulator
K2224_RS35715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K2224_RS35720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K2224_RS35735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K2224_RS35745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K2224_RS35750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K2224_RS35765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K2224_RS35770	COG0583	DNA-binding transcription factor activity
K2224_RS35820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K2224_RS35825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K2224_RS35845	COG0529	Catalyzes the synthesis of activated sulfate
K2224_RS35850	COG0175	sulfate reduction
K2224_RS35860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K2224_RS35880	COG1960	acyl-CoA dehydrogenase activity
K2224_RS35890	COG1414	Transcriptional regulator
K2224_RS35895	COG3485	protocatechuate 3,4-dioxygenase
K2224_RS35900	COG3485	protocatechuate 3,4-dioxygenase
K2224_RS35920	COG2208	phosphoserine phosphatase activity
K2224_RS35920	COG2770	Histidine kinase
K2224_RS35930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K2224_RS35950	COG2080	2 iron, 2 sulfur cluster binding
K2224_RS35955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K2224_RS35960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K2224_RS35970	COG3511	phospholipase C
K2224_RS35975	COG0667	Aldo Keto reductase
K2224_RS35980	COG1376	ErfK ybiS ycfS ynhG family protein
K2224_RS36005	COG1131	(ABC) transporter
K2224_RS36005	COG0842	Transport permease protein
K2224_RS36005	COG1716	ATPase activity
K2224_RS36010	COG2233	PERMEase
K2224_RS36025	COG2755	lipolytic protein G-D-S-L family
K2224_RS36025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K2224_RS36055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS36055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS36060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K2224_RS36075	COG0640	Transcriptional regulator
K2224_RS36085	COG0789	Transcriptional regulator
K2224_RS36090	COG1162	GTPase activity
K2224_RS36105	COG0028	Belongs to the TPP enzyme family
K2224_RS36130	COG1802	Transcriptional regulator
K2224_RS36145	COG3835	regulator
K2224_RS36160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K2224_RS36180	COG1733	regulation of RNA biosynthetic process
K2224_RS36200	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS36210	COG2814	Major facilitator Superfamily
K2224_RS36215	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS36225	COG2315	Protein conserved in bacteria
K2224_RS36240	COG0753	catalase activity
K2224_RS36245	COG0028	Belongs to the TPP enzyme family
K2224_RS36250	COG2084	Dehydrogenase
K2224_RS36255	COG3622	Belongs to the hyi family
K2224_RS36295	COG2351	hydroxyisourate hydrolase activity
K2224_RS36305	COG2233	PERMEase
K2224_RS36315	COG2233	PERMEase
K2224_RS36335	COG1288	antiporter activity
K2224_RS36350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K2224_RS36370	COG1414	Transcriptional regulator
K2224_RS36380	COG1953	Uracil, thiamine, allantoin
K2224_RS36385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K2224_RS36390	COG4266	Belongs to the allantoicase family
K2224_RS36420	COG0800	Aldolase
K2224_RS36435	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS36440	COG2188	Transcriptional regulator
K2224_RS36450	COG1172	Belongs to the binding-protein-dependent transport system permease family
K2224_RS36460	COG1940	carbohydrate kinase activity
K2224_RS36475	COG0488	(ABC) transporter
K2224_RS36480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K2224_RS36485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K2224_RS36500	COG1126	abc transporter atp-binding protein
K2224_RS36505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K2224_RS36510	COG0765	amino acid transport
K2224_RS36515	COG0765	amino acid transport
K2224_RS36530	COG2226	methyltransferase
K2224_RS36555	COG2409	Drug exporters of the RND superfamily
K2224_RS36560	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS36565	COG0387	Pfam Sodium calcium exchanger
K2224_RS36575	COG0405	Gamma-glutamyltransferase
K2224_RS36585	COG1335	isochorismatase
K2224_RS36590	COG0477	Major facilitator Superfamily
K2224_RS36620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K2224_RS36635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K2224_RS36650	COG1595	DNA-templated transcription, initiation
K2224_RS36655	COG0180	Tryptophanyl-tRNA synthetase
K2224_RS36665	COG0243	molybdopterin cofactor binding
K2224_RS36690	COG0095	Lipoate-protein ligase
K2224_RS36700	COG4221	oxidoreductase activity
K2224_RS36705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K2224_RS36715	COG0483	inositol monophosphate 1-phosphatase activity
K2224_RS36730	COG3848	Pyruvate phosphate dikinase
K2224_RS36730	COG0574	Belongs to the PEP-utilizing enzyme family
K2224_RS36780	COG0494	nUDIX hydrolase
K2224_RS36785	COG1929	Belongs to the glycerate kinase type-1 family
K2224_RS36795	COG0688	phosphatidylethanolamine metabolic process
K2224_RS36800	COG1960	acyl-CoA dehydrogenase activity
K2224_RS36810	COG2301	Belongs to the HpcH HpaI aldolase family
K2224_RS36815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K2224_RS36815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K2224_RS36835	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS36880	COG0366	Alpha amylase catalytic
K2224_RS36890	COG2362	D-Aminopeptidase
K2224_RS36895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2224_RS36925	COG2124	cytochrome p450
K2224_RS36940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K2224_RS37015	COG0010	Belongs to the arginase family
K2224_RS37025	COG0604	alcohol dehydrogenase
K2224_RS37030	COG1278	Cold shock
K2224_RS37040	COG0515	serine threonine protein kinase
K2224_RS37045	COG1505	serine-type exopeptidase activity
K2224_RS37090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K2224_RS37100	COG0531	amino acid
K2224_RS37135	COG2154	pterin-4-alpha-carbinolamine dehydratase
K2224_RS37150	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS37160	COG0656	L-ascorbic acid biosynthetic process
K2224_RS37260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K2224_RS37270	COG0287	Prephenate dehydrogenase
K2224_RS37270	COG1605	Chorismate mutase
K2224_RS37290	COG1793	dna ligase
K2224_RS37290	COG3285	dna ligase
K2224_RS37300	COG2207	Transcriptional regulator
K2224_RS37300	COG3708	Transcriptional regulator
K2224_RS37335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K2224_RS37410	COG0791	NLP P60 protein
K2224_RS37410	COG1388	LysM domain
K2224_RS37455	COG2255	four-way junction helicase activity
K2224_RS37600	COG1404	Belongs to the peptidase S8 family
K2224_RS37605	COG3266	domain, Protein
K2224_RS37615	COG1674	ftsk spoiiie
K2224_RS37630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2224_RS37635	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K2224_RS37645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K2224_RS37650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K2224_RS37680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2224_RS37680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2224_RS37775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K2224_RS37810	COG4104	PAAR repeat-containing protein
K2224_RS37810	COG4104	PAAR repeat-containing protein
K2224_RS37810	COG3209	COG3209 Rhs family protein
K2224_RS37810	COG3209	COG3209 Rhs family protein
K2224_RS37840	COG1333	cytochrome c biogenesis protein
K2224_RS37845	COG2814	Major facilitator Superfamily
K2224_RS37950	COG0464	growth
K2224_RS38035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K2224_RS38070	COG3226	Transcriptional regulator
K2224_RS38080	COG0251	oxidation-reduction process
K2224_RS38150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K2224_RS38205	COG1285	pathogenesis
K2224_RS38210	COG2409	Drug exporters of the RND superfamily
K2224_RS38215	COG1562	ergosterol biosynthetic process
K2224_RS38220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K2224_RS38260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2224_RS38260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2224_RS38280	COG1834	amidinotransferase
K2224_RS38295	COG0475	glutathione-regulated potassium exporter activity
K2224_RS38300	COG2175	clavaminate synthase activity
K2224_RS38315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K2224_RS38335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2224_RS38350	COG0583	DNA-binding transcription factor activity
K2224_RS38395	COG0589	response to stress
K2224_RS38405	COG0516	GMP reductase activity
K2224_RS38405	COG0517	IMP dehydrogenase activity
K2224_RS38415	COG4109	DRTGG domain
K2224_RS38475	COG0589	response to stress
K2224_RS38490	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K2224_RS38510	COG1269	ATP hydrolysis coupled proton transport
K2224_RS38545	COG0517	IMP dehydrogenase activity
K2224_RS38595	COG1278	Cold shock
K2224_RS38605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2224_RS38620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2224_RS38655	COG3655	Transcriptional regulator
K2224_RS38665	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS38680	COG1960	acyl-CoA dehydrogenase activity
K2224_RS38705	COG1733	regulation of RNA biosynthetic process
K2224_RS38715	COG0492	ferredoxin-NADP+ reductase activity
K2224_RS38750	COG0110	maltose O-acetyltransferase activity
K2224_RS38770	COG1028	Short-chain dehydrogenase reductase Sdr
K2224_RS38815	COG1132	(ABC) transporter
K2224_RS38820	COG4106	trans-aconitate 2-methyltransferase activity
K2224_RS38845	COG1131	(ABC) transporter
K2224_RS38860	COG2197	response regulator
K2224_RS38900	COG4585	Histidine kinase
K2224_RS38905	COG2197	response regulator
K2224_RS38995	COG4585	Histidine kinase
K2224_RS39020	COG0667	Aldo Keto reductase
K2224_RS39040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K2224_RS39045	COG0390	transport system, permease component
K2224_RS39070	COG1473	amidohydrolase
K2224_RS39090	COG1733	regulation of RNA biosynthetic process
K2224_RS39115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS39125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K2224_RS39165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2224_RS39185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K2224_RS39215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K2224_RS39280	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS39310	COG3629	intracellular signal transduction
K2224_RS39310	COG3903	Transcriptional regulator
K2224_RS39315	COG3629	intracellular signal transduction
K2224_RS39315	COG3903	Transcriptional regulator
K2224_RS39325	COG1113	amino acid transport
K2224_RS39345	COG0076	glutamate decarboxylase activity
K2224_RS39350	COG2197	response regulator
K2224_RS39380	COG0583	DNA-binding transcription factor activity
K2224_RS39385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2224_RS39405	COG1510	regulation of RNA biosynthetic process
K2224_RS39415	COG2815	serine threonine protein kinase
K2224_RS39415	COG0515	serine threonine protein kinase
K2224_RS39445	COG2814	Major facilitator Superfamily
K2224_RS39455	COG3547	Transposase (IS116 IS110 IS902 family)
K2224_RS39490	COG2197	response regulator
K2224_RS39525	COG0477	Major facilitator Superfamily
K2224_RS39530	COG1113	amino acid transport
K2224_RS39535	COG0137	argininosuccinate synthase activity
K2224_RS39645	COG1309	transcriptional regulator
K2224_RS39665	COG1846	Transcriptional regulator
K2224_RS39670	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K2224_RS39685	COG1012	belongs to the aldehyde dehydrogenase family
K2224_RS39700	COG1136	(ABC) transporter
K2224_RS39760	COG2205	protein histidine kinase activity
K2224_RS39765	COG0745	RESPONSE REGULATOR receiver
K2224_RS39790	COG3226	Transcriptional regulator
K2224_RS39800	COG1846	Transcriptional regulator
K2224_RS39810	COG1309	transcriptional regulator
K2224_RS39820	COG1309	transcriptional regulator
K2224_RS39830	COG1349	DNA-binding transcription factor activity
K2224_RS39840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2224_RS39845	COG2814	Major facilitator Superfamily
K2224_RS39855	COG1515	deoxyribonuclease V activity
K2224_RS39860	COG3268	Saccharopine dehydrogenase
K2224_RS39870	COG1285	pathogenesis
K2224_RS39875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K2224_RS39880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2224_RS39885	COG1960	acyl-CoA dehydrogenase activity
K2224_RS39890	COG0183	Belongs to the thiolase family
K2224_RS39895	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2224_RS39895	COG1024	Enoyl-CoA hydratase
K2224_RS39900	COG0789	Transcriptional regulator
K2224_RS39910	COG1113	amino acid transport
K2224_RS39915	COG3568	Endonuclease Exonuclease Phosphatase
K2224_RS39940	COG2936	dipeptidyl-peptidase activity
K2224_RS39965	COG2183	response to ionizing radiation
K2224_RS39975	COG4977	sequence-specific DNA binding
K2224_RS39990	COG0488	(ABC) transporter
K2224_RS40010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K2224_RS40045	COG1134	teichoic acid transport
K2224_RS40050	COG1562	ergosterol biosynthetic process
K2224_RS40060	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K2224_RS40070	COG1657	PFAM Prenyltransferase squalene oxidase
K2224_RS40090	COG2365	Tyrosine phosphatase family
K2224_RS40095	COG2755	lipolytic protein G-D-S-L family
K2224_RS40120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2224_RS40175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K2224_RS40230	COG2205	protein histidine kinase activity
K2224_RS40250	COG0494	nUDIX hydrolase
K2224_RS40305	COG3209	COG3209 Rhs family protein
K2224_RS40440	COG0792	nuclease activity
K2224_RS40470	COG4974	Belongs to the 'phage' integrase family
K2224_RS40545	COG0604	alcohol dehydrogenase
K2224_RS40545	COG3321	synthase
K2224_RS40550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K2224_RS40745	COG1960	acyl-CoA dehydrogenase activity
K2224_RS40910	COG0318	PFAM AMP-dependent synthetase and ligase
K2224_RS40915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K2224_RS40940	COG4257	antibiotic catabolic process