locus-tag	class	description
HYC88_RS00040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS00045	COG0601	transmembrane transport
HYC88_RS00055	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS00060	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS00080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYC88_RS00090	COG0517	IMP dehydrogenase activity
HYC88_RS00090	COG1125	glycine betaine transport
HYC88_RS00105	COG1174	glycine betaine transport
HYC88_RS00110	COG1174	glycine betaine transport
HYC88_RS00145	COG0297	glycogen (starch) synthase activity
HYC88_RS00145	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS00150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYC88_RS00165	COG0726	polysaccharide deacetylase
HYC88_RS00170	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS00190	COG2304	oxidoreductase activity
HYC88_RS00215	COG1132	(ABC) transporter
HYC88_RS00245	COG1120	ATPase activity
HYC88_RS00250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS00255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS00270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYC88_RS00275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYC88_RS00280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYC88_RS00285	COG0254	rRNA binding
HYC88_RS00295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYC88_RS00305	COG1120	ATPase activity
HYC88_RS00355	COG0156	8-amino-7-oxononanoate synthase activity
HYC88_RS00365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYC88_RS00370	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HYC88_RS00395	COG0577	efflux transmembrane transporter activity
HYC88_RS00400	COG0577	efflux transmembrane transporter activity
HYC88_RS00400	COG1136	(ABC) transporter
HYC88_RS00415	COG2814	Major facilitator Superfamily
HYC88_RS00435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS00440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS00455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS00460	COG1132	(ABC) transporter
HYC88_RS00465	COG1132	(ABC) transporter
HYC88_RS00485	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HYC88_RS00510	COG0563	adenylate kinase activity
HYC88_RS00520	COG0367	asparagine synthase
HYC88_RS00545	COG3959	Transketolase, thiamine diphosphate binding domain
HYC88_RS00550	COG3958	Transketolase
HYC88_RS00565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYC88_RS00570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYC88_RS00575	COG0656	L-ascorbic acid biosynthetic process
HYC88_RS00590	COG2192	nodulation
HYC88_RS00670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HYC88_RS00685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYC88_RS00690	COG1228	amidohydrolase
HYC88_RS00695	COG1834	amidinotransferase
HYC88_RS00705	COG0697	spore germination
HYC88_RS00715	COG2045	Belongs to the ComB family
HYC88_RS00725	COG0640	Transcriptional regulator
HYC88_RS00730	COG0492	ferredoxin-NADP+ reductase activity
HYC88_RS00750	COG1937	Protein conserved in bacteria
HYC88_RS00765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYC88_RS00765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYC88_RS00795	COG0604	alcohol dehydrogenase
HYC88_RS00795	COG3321	synthase
HYC88_RS00855	COG1733	regulation of RNA biosynthetic process
HYC88_RS00865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYC88_RS00890	COG1695	Transcriptional regulator
HYC88_RS00905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYC88_RS00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYC88_RS00920	COG1609	Transcriptional regulator
HYC88_RS00940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYC88_RS00945	COG0121	glutamine amidotransferase
HYC88_RS00950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HYC88_RS00965	COG2182	Extracellular solute-binding protein
HYC88_RS00970	COG3360	Dodecin
HYC88_RS00980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS00990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYC88_RS00995	COG1053	succinate dehydrogenase
HYC88_RS01005	COG0583	DNA-binding transcription factor activity
HYC88_RS01075	COG3275	phosphorelay sensor kinase activity
HYC88_RS01080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYC88_RS01095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYC88_RS01140	COG1191	sigma factor activity
HYC88_RS01145	COG2201	protein-glutamate methylesterase activity
HYC88_RS01150	COG4251	negative regulation of phosphorylation
HYC88_RS01155	COG0784	Response regulator, receiver
HYC88_RS01200	COG1652	LysM domain
HYC88_RS01215	COG1940	carbohydrate kinase activity
HYC88_RS01225	COG1175	transmembrane transport
HYC88_RS01230	COG0395	ABC-type sugar transport system, permease component
HYC88_RS01235	COG2723	6-phospho-beta-galactosidase activity
HYC88_RS01245	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HYC88_RS01310	COG2267	carboxylic ester hydrolase activity
HYC88_RS01315	COG0789	Transcriptional regulator
HYC88_RS01350	COG2197	response regulator
HYC88_RS01370	COG1119	ATPase activity
HYC88_RS01395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYC88_RS01405	COG2837	iron assimilation
HYC88_RS01415	COG0019	diaminopimelate decarboxylase activity
HYC88_RS01425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYC88_RS01455	COG0640	Transcriptional regulator
HYC88_RS01465	COG2072	flavoprotein involved in K transport
HYC88_RS01485	COG2072	flavoprotein involved in K transport
HYC88_RS01495	COG0798	PFAM Bile acid sodium symporter
HYC88_RS01505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYC88_RS01510	COG0492	ferredoxin-NADP+ reductase activity
HYC88_RS01525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYC88_RS01530	COG0745	RESPONSE REGULATOR receiver
HYC88_RS01535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYC88_RS01540	COG0581	inorganic phosphate transmembrane transporter activity
HYC88_RS01545	COG0573	inorganic phosphate transmembrane transporter activity
HYC88_RS01550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYC88_RS01800	COG1228	amidohydrolase
HYC88_RS01830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYC88_RS01845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYC88_RS01915	COG2319	Wd-40 repeat
HYC88_RS01915	COG4249	Peptidase C14 caspase catalytic subunit p20
HYC88_RS01950	COG0300	oxidoreductase activity
HYC88_RS01950	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS01950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS01950	COG3321	synthase
HYC88_RS01970	COG2197	response regulator
HYC88_RS01975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYC88_RS01980	COG3403	YqcI/YcgG family
HYC88_RS01985	COG2124	cytochrome p450
HYC88_RS02050	COG2124	cytochrome p450
HYC88_RS02115	COG2124	cytochrome p450
HYC88_RS02120	COG2130	NADP-dependent
HYC88_RS02125	COG1233	COG1233 Phytoene dehydrogenase and related
HYC88_RS02170	COG1846	Transcriptional regulator
HYC88_RS02175	COG2409	Drug exporters of the RND superfamily
HYC88_RS02190	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYC88_RS02190	COG1902	pentaerythritol trinitrate reductase activity
HYC88_RS02225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYC88_RS02255	COG1414	Transcriptional regulator
HYC88_RS02260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYC88_RS02270	COG3833	ABC-type maltose transport systems, permease component
HYC88_RS02325	COG1482	cell wall glycoprotein biosynthetic process
HYC88_RS02335	COG1609	Transcriptional regulator
HYC88_RS02350	COG1175	transmembrane transport
HYC88_RS02355	COG3833	ABC-type maltose transport systems, permease component
HYC88_RS02395	COG1556	Lactate utilization protein
HYC88_RS02400	COG1139	Iron-sulfur cluster binding protein
HYC88_RS02405	COG0247	lactate metabolic process
HYC88_RS02410	COG2186	Transcriptional regulator
HYC88_RS02420	COG3851	Histidine kinase
HYC88_RS02425	COG2197	response regulator
HYC88_RS02435	COG3511	phospholipase C
HYC88_RS02455	COG0714	Associated with various cellular activities
HYC88_RS02475	COG0477	Major facilitator Superfamily
HYC88_RS02485	COG3959	Transketolase, thiamine diphosphate binding domain
HYC88_RS02490	COG3958	Transketolase
HYC88_RS02500	COG3507	Belongs to the glycosyl hydrolase 43 family
HYC88_RS02520	COG1116	anion transmembrane transporter activity
HYC88_RS02530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYC88_RS02535	COG1609	Transcriptional regulator
HYC88_RS02590	COG0789	Transcriptional regulator
HYC88_RS02655	COG3467	pyridoxamine 5'-phosphate
HYC88_RS02695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYC88_RS02705	COG2755	lipolytic protein G-D-S-L family
HYC88_RS02710	COG0739	heme binding
HYC88_RS02745	COG1657	PFAM Prenyltransferase squalene oxidase
HYC88_RS02755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HYC88_RS02765	COG1562	ergosterol biosynthetic process
HYC88_RS02770	COG1134	teichoic acid transport
HYC88_RS02790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYC88_RS02805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYC88_RS02820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYC88_RS02835	COG1024	Enoyl-CoA hydratase
HYC88_RS02845	COG4977	sequence-specific DNA binding
HYC88_RS02855	COG2183	response to ionizing radiation
HYC88_RS02860	COG0488	(ABC) transporter
HYC88_RS02870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYC88_RS02895	COG0789	Transcriptional regulator
HYC88_RS02900	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYC88_RS02900	COG1024	Enoyl-CoA hydratase
HYC88_RS02905	COG0183	Belongs to the thiolase family
HYC88_RS02910	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS02915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYC88_RS02920	COG3268	Saccharopine dehydrogenase
HYC88_RS02930	COG1515	deoxyribonuclease V activity
HYC88_RS02950	COG0488	(ABC) transporter
HYC88_RS02955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYC88_RS02985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYC88_RS02990	COG1116	anion transmembrane transporter activity
HYC88_RS02995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYC88_RS03045	COG1793	dna ligase
HYC88_RS03080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HYC88_RS03105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYC88_RS03150	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS03170	COG3012	SEC-C Motif Domain Protein
HYC88_RS03200	COG1486	melibiose metabolic process
HYC88_RS03205	COG2124	cytochrome p450
HYC88_RS03230	COG1846	Transcriptional regulator
HYC88_RS03255	COG1940	carbohydrate kinase activity
HYC88_RS03265	COG1070	Carbohydrate kinase
HYC88_RS03275	COG0488	(ABC) transporter
HYC88_RS03305	COG0569	domain protein
HYC88_RS03305	COG2985	domain, Protein
HYC88_RS03325	COG4176	ABC-type proline glycine betaine transport system permease component
HYC88_RS03330	COG4175	Glycine betaine
HYC88_RS03330	COG0517	IMP dehydrogenase activity
HYC88_RS03340	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS03395	COG0745	RESPONSE REGULATOR receiver
HYC88_RS03400	COG5002	protein histidine kinase activity
HYC88_RS03425	COG3629	intracellular signal transduction
HYC88_RS03425	COG3903	Transcriptional regulator
HYC88_RS03440	COG0714	Associated with various cellular activities
HYC88_RS03450	COG1869	D-ribose catabolic process
HYC88_RS03455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYC88_RS03465	COG1129	ABC transporter
HYC88_RS03520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYC88_RS03540	COG0673	inositol 2-dehydrogenase activity
HYC88_RS03545	COG1879	ABC-type sugar transport system periplasmic component
HYC88_RS03550	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYC88_RS03555	COG1129	ABC transporter
HYC88_RS03565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYC88_RS03570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYC88_RS03590	COG0656	L-ascorbic acid biosynthetic process
HYC88_RS03615	COG4106	trans-aconitate 2-methyltransferase activity
HYC88_RS03625	COG0702	epimerase
HYC88_RS03635	COG2154	pterin-4-alpha-carbinolamine dehydratase
HYC88_RS03645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYC88_RS03645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYC88_RS03660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYC88_RS03730	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYC88_RS03740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYC88_RS03745	COG2362	D-Aminopeptidase
HYC88_RS03750	COG0667	Aldo Keto reductase
HYC88_RS03755	COG0583	DNA-binding transcription factor activity
HYC88_RS03785	COG0596	Alpha beta hydrolase
HYC88_RS03795	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYC88_RS03810	COG0604	alcohol dehydrogenase
HYC88_RS03815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYC88_RS03815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYC88_RS03820	COG2301	Belongs to the HpcH HpaI aldolase family
HYC88_RS03830	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS03835	COG0688	phosphatidylethanolamine metabolic process
HYC88_RS03880	COG0559	Belongs to the binding-protein-dependent transport system permease family
HYC88_RS03900	COG1929	Belongs to the glycerate kinase type-1 family
HYC88_RS03935	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS03960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYC88_RS03990	COG1024	Enoyl-CoA hydratase
HYC88_RS03995	COG1131	(ABC) transporter
HYC88_RS04005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS04015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYC88_RS04020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYC88_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS04060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS04065	COG1024	Enoyl-CoA hydratase
HYC88_RS04070	COG2267	carboxylic ester hydrolase activity
HYC88_RS04095	COG1309	transcriptional regulator
HYC88_RS04105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYC88_RS04125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYC88_RS04140	COG0095	Lipoate-protein ligase
HYC88_RS04155	COG2838	Isocitrate dehydrogenase
HYC88_RS04160	COG2197	response regulator
HYC88_RS04225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYC88_RS04230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYC88_RS04265	COG0405	Gamma-glutamyltransferase
HYC88_RS04285	COG0640	Transcriptional regulator
HYC88_RS04295	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HYC88_RS04330	COG0765	amino acid transport
HYC88_RS04335	COG0765	amino acid transport
HYC88_RS04340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS04345	COG1126	abc transporter atp-binding protein
HYC88_RS04355	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS04370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYC88_RS04375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYC88_RS04480	COG0187	DNA topoisomerase II activity
HYC88_RS04505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYC88_RS04515	COG1940	carbohydrate kinase activity
HYC88_RS04520	COG1129	ABC transporter
HYC88_RS04530	COG1879	ABC-type sugar transport system periplasmic component
HYC88_RS04535	COG2188	Transcriptional regulator
HYC88_RS04540	COG0673	inositol 2-dehydrogenase activity
HYC88_RS04555	COG2197	response regulator
HYC88_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS04585	COG0656	L-ascorbic acid biosynthetic process
HYC88_RS04595	COG4266	Belongs to the allantoicase family
HYC88_RS04600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYC88_RS04605	COG1414	Transcriptional regulator
HYC88_RS04610	COG1136	(ABC) transporter
HYC88_RS04625	COG2197	response regulator
HYC88_RS04640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HYC88_RS04645	COG1288	antiporter activity
HYC88_RS04680	COG2233	PERMEase
HYC88_RS04690	COG2233	PERMEase
HYC88_RS04700	COG2351	hydroxyisourate hydrolase activity
HYC88_RS04720	COG2706	6-phosphogluconolactonase activity
HYC88_RS04725	COG3622	Belongs to the hyi family
HYC88_RS04730	COG2084	Dehydrogenase
HYC88_RS04735	COG0753	catalase activity
HYC88_RS04740	COG3960	tartronate-semialdehyde synthase activity
HYC88_RS04760	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS04765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYC88_RS04770	COG2197	response regulator
HYC88_RS04785	COG0435	Glutathione S-transferase
HYC88_RS04815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS04835	COG1309	transcriptional regulator
HYC88_RS04860	COG1404	Belongs to the peptidase S8 family
HYC88_RS04865	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYC88_RS04865	COG3608	succinylglutamate desuccinylase aspartoacylase
HYC88_RS04870	COG2252	PERMEase
HYC88_RS04875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYC88_RS04900	COG1802	Transcriptional regulator
HYC88_RS04925	COG0028	Belongs to the TPP enzyme family
HYC88_RS04935	COG1404	Belongs to the peptidase S8 family
HYC88_RS04955	COG1162	GTPase activity
HYC88_RS05005	COG0183	Belongs to the thiolase family
HYC88_RS05015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYC88_RS05020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HYC88_RS05050	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS05075	COG0175	sulfate reduction
HYC88_RS05080	COG0529	Catalyzes the synthesis of activated sulfate
HYC88_RS05100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HYC88_RS05105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYC88_RS05115	COG1120	ATPase activity
HYC88_RS05120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS05125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS05130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HYC88_RS05135	COG1132	(ABC) transporter
HYC88_RS05140	COG1132	(ABC) transporter
HYC88_RS05150	COG3903	Transcriptional regulator
HYC88_RS05150	COG3629	intracellular signal transduction
HYC88_RS05165	COG1404	Belongs to the peptidase S8 family
HYC88_RS05185	COG1175	transmembrane transport
HYC88_RS05225	COG0583	DNA-binding transcription factor activity
HYC88_RS05230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYC88_RS05275	COG1072	(Pantothenic acid kinase))
HYC88_RS05280	COG0346	lactoylglutathione lyase activity
HYC88_RS05285	COG2197	response regulator
HYC88_RS05295	COG1136	(ABC) transporter
HYC88_RS05305	COG0583	DNA-binding transcription factor activity
HYC88_RS05310	COG0156	8-amino-7-oxononanoate synthase activity
HYC88_RS05315	COG1063	alcohol dehydrogenase
HYC88_RS05370	COG2755	lipolytic protein G-D-S-L family
HYC88_RS05370	COG0657	acetylesterase activity
HYC88_RS05425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYC88_RS05430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYC88_RS05485	COG4152	abc transporter atp-binding protein
HYC88_RS05505	COG3220	belongs to the UPF0276 family
HYC88_RS05520	COG3253	May function as heme-dependent peroxidase
HYC88_RS05525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HYC88_RS05535	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYC88_RS05540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYC88_RS05560	COG0183	Belongs to the thiolase family
HYC88_RS05565	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYC88_RS05565	COG1024	Enoyl-CoA hydratase
HYC88_RS05575	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS05585	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS05600	COG1316	TRANSCRIPTIONal
HYC88_RS05630	COG2814	Major facilitator Superfamily
HYC88_RS05635	COG1505	serine-type exopeptidase activity
HYC88_RS05640	COG0531	amino acid
HYC88_RS05645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYC88_RS05650	COG4214	carbohydrate transport
HYC88_RS05660	COG4213	ABC transporter substrate-binding protein
HYC88_RS05665	COG1940	carbohydrate kinase activity
HYC88_RS05670	COG0395	ABC-type sugar transport system, permease component
HYC88_RS05675	COG1175	transmembrane transport
HYC88_RS05680	COG1653	transport
HYC88_RS05690	COG0406	alpha-ribazole phosphatase activity
HYC88_RS05700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYC88_RS05735	COG0515	serine threonine protein kinase
HYC88_RS05735	COG2815	serine threonine protein kinase
HYC88_RS05740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYC88_RS05740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYC88_RS05765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYC88_RS05800	COG2319	Wd-40 repeat
HYC88_RS05810	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS05845	COG1228	amidohydrolase
HYC88_RS05860	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS05885	COG2197	response regulator
HYC88_RS05890	COG1120	ATPase activity
HYC88_RS05895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS05900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYC88_RS05910	COG1132	(ABC) transporter
HYC88_RS05950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYC88_RS05960	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS06000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYC88_RS06005	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HYC88_RS06025	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS06045	COG0297	glycogen (starch) synthase activity
HYC88_RS06065	COG1320	monovalent cation:proton antiporter activity
HYC88_RS06080	COG0651	ATP synthesis coupled electron transport
HYC88_RS06085	COG1006	Multisubunit Na H antiporter MnhC subunit
HYC88_RS06090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYC88_RS06090	COG2111	Na H antiporter
HYC88_RS06145	COG1024	Enoyl-CoA hydratase
HYC88_RS06155	COG0531	amino acid
HYC88_RS06160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYC88_RS06170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYC88_RS06180	COG2040	homocysteine
HYC88_RS06200	COG1799	cell septum assembly
HYC88_RS06205	COG1349	DNA-binding transcription factor activity
HYC88_RS06210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYC88_RS06215	COG0586	Pfam SNARE associated Golgi protein
HYC88_RS06225	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS06230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS06260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYC88_RS06265	COG1280	lysine exporter protein (LysE YggA)
HYC88_RS06275	COG3291	Pkd domain containing protein
HYC88_RS06280	COG4608	Belongs to the ABC transporter superfamily
HYC88_RS06290	COG0601	transmembrane transport
HYC88_RS06295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS06300	COG0747	negative chemotaxis
HYC88_RS06305	COG0006	proline dipeptidase activity
HYC88_RS06310	COG1802	Transcriptional regulator
HYC88_RS06315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYC88_RS06320	COG3938	Belongs to the proline racemase family
HYC88_RS06325	COG3938	Belongs to the proline racemase family
HYC88_RS06335	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYC88_RS06345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYC88_RS06375	COG0363	glucosamine-6-phosphate deaminase activity
HYC88_RS06380	COG1940	carbohydrate kinase activity
HYC88_RS06385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYC88_RS06400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYC88_RS06405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYC88_RS06415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYC88_RS06420	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS06425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS06435	COG1132	(ABC) transporter
HYC88_RS06440	COG2124	cytochrome p450
HYC88_RS06445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYC88_RS06460	COG2084	Dehydrogenase
HYC88_RS06475	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS06490	COG0657	acetylesterase activity
HYC88_RS06515	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HYC88_RS06530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYC88_RS06535	COG0531	amino acid
HYC88_RS06540	COG0569	domain protein
HYC88_RS06570	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYC88_RS06570	COG1136	(ABC) transporter
HYC88_RS06580	COG0756	dUTP diphosphatase activity
HYC88_RS06605	COG2205	protein histidine kinase activity
HYC88_RS06610	COG0745	RESPONSE REGULATOR receiver
HYC88_RS06625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYC88_RS06665	COG1435	thymidine kinase activity
HYC88_RS06685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYC88_RS06690	COG1802	Transcriptional regulator
HYC88_RS06705	COG0612	Peptidase, M16
HYC88_RS06710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYC88_RS06715	COG0523	cobalamin synthesis protein
HYC88_RS06720	COG0372	Belongs to the citrate synthase family
HYC88_RS06725	COG0372	Belongs to the citrate synthase family
HYC88_RS06735	COG3290	protein histidine kinase activity
HYC88_RS06740	COG4565	transcriptional regulatory protein
HYC88_RS06745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYC88_RS06770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYC88_RS06775	COG2186	Transcriptional regulator
HYC88_RS06805	COG0596	Alpha beta hydrolase
HYC88_RS06835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYC88_RS06865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYC88_RS06870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYC88_RS06875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYC88_RS06915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYC88_RS06925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYC88_RS06930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYC88_RS06940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYC88_RS06955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYC88_RS06960	COG2358	TRAP transporter, solute receptor (TAXI family
HYC88_RS06965	COG2205	protein histidine kinase activity
HYC88_RS06970	COG0745	RESPONSE REGULATOR receiver
HYC88_RS06975	COG1126	abc transporter atp-binding protein
HYC88_RS06980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS06985	COG0765	amino acid transport
HYC88_RS06990	COG0765	amino acid transport
HYC88_RS06995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYC88_RS07005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYC88_RS07020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYC88_RS07055	COG1917	Cupin 2, conserved barrel domain protein
HYC88_RS07055	COG2207	Transcriptional regulator
HYC88_RS07060	COG1201	RNA secondary structure unwinding
HYC88_RS07070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYC88_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS07085	COG0783	Belongs to the Dps family
HYC88_RS07090	COG1396	sequence-specific DNA binding
HYC88_RS07095	COG1546	Belongs to the CinA family
HYC88_RS07095	COG1058	Belongs to the CinA family
HYC88_RS07105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYC88_RS07115	COG1674	ftsk spoiiie
HYC88_RS07125	COG3850	Histidine kinase
HYC88_RS07125	COG2205	protein histidine kinase activity
HYC88_RS07125	COG3437	response regulator, receiver
HYC88_RS07125	COG4999	Histidine kinase
HYC88_RS07130	COG2770	Histidine kinase
HYC88_RS07130	COG2208	phosphoserine phosphatase activity
HYC88_RS07155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYC88_RS07160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYC88_RS07165	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HYC88_RS07185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYC88_RS07190	COG0612	Peptidase, M16
HYC88_RS07195	COG1185	polyribonucleotide nucleotidyltransferase activity
HYC88_RS07200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYC88_RS07210	COG1674	ftsk spoiiie
HYC88_RS07225	COG1404	Belongs to the peptidase S8 family
HYC88_RS07240	COG1404	Belongs to the peptidase S8 family
HYC88_RS07245	COG3266	domain, Protein
HYC88_RS07265	COG0455	bacterial-type flagellum organization
HYC88_RS07270	COG0747	negative chemotaxis
HYC88_RS07275	COG0601	transmembrane transport
HYC88_RS07280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS07320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYC88_RS07325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYC88_RS07350	COG0779	Required for maturation of 30S ribosomal subunits
HYC88_RS07370	COG0442	prolyl-tRNA aminoacylation
HYC88_RS07385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYC88_RS07390	COG0750	zinc metalloprotease
HYC88_RS07395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYC88_RS07400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYC88_RS07410	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS07415	COG2508	Transcriptional regulator
HYC88_RS07445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYC88_RS07450	COG1177	transmembrane transport
HYC88_RS07455	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYC88_RS07460	COG3842	ATPase activity
HYC88_RS07465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HYC88_RS07485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYC88_RS07500	COG4585	Histidine kinase
HYC88_RS07505	COG2197	response regulator
HYC88_RS07525	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS07535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYC88_RS07540	COG1136	(ABC) transporter
HYC88_RS07555	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS07570	COG2197	response regulator
HYC88_RS07575	COG3842	ATPase activity
HYC88_RS07590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYC88_RS07595	COG0575	Belongs to the CDS family
HYC88_RS07600	COG0233	cytoplasmic translational termination
HYC88_RS07605	COG0528	UMP kinase activity
HYC88_RS07610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYC88_RS07615	COG0052	Belongs to the universal ribosomal protein uS2 family
HYC88_RS07630	COG1191	sigma factor activity
HYC88_RS07645	COG0792	nuclease activity
HYC88_RS07655	COG1051	belongs to the nudix hydrolase family
HYC88_RS07670	COG0681	Belongs to the peptidase S26 family
HYC88_RS07675	COG0681	Belongs to the peptidase S26 family
HYC88_RS07680	COG0335	large ribosomal subunit rRNA binding
HYC88_RS07685	COG0336	Belongs to the RNA methyltransferase TrmD family
HYC88_RS07690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYC88_RS07695	COG1837	Belongs to the UPF0109 family
HYC88_RS07700	COG0228	four-way junction DNA binding
HYC88_RS07720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HYC88_RS07755	COG0477	Major facilitator Superfamily
HYC88_RS07760	COG1196	nuclear chromosome segregation
HYC88_RS07770	COG1254	Belongs to the acylphosphatase family
HYC88_RS07775	COG2340	Cysteine-rich secretory protein family
HYC88_RS07780	COG1733	regulation of RNA biosynthetic process
HYC88_RS07785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYC88_RS07790	COG0571	ribonuclease III activity
HYC88_RS07795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYC88_RS07810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYC88_RS07815	COG0742	ribosomal rna small subunit methyltransferase
HYC88_RS07820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYC88_RS07825	COG1461	Dihydroxyacetone kinase
HYC88_RS07830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYC88_RS07835	COG0351	phosphomethylpyrimidine kinase
HYC88_RS07855	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYC88_RS07860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYC88_RS07870	COG1920	GTP binding
HYC88_RS07880	COG0776	regulation of translation
HYC88_RS07890	COG0066	3-isopropylmalate dehydratase activity
HYC88_RS07895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYC88_RS07900	COG1414	Transcriptional regulator
HYC88_RS07935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYC88_RS07940	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYC88_RS07950	COG5002	protein histidine kinase activity
HYC88_RS07955	COG2018	Roadblock/LC7 domain
HYC88_RS07975	COG2018	Roadblock/LC7 domain
HYC88_RS07995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYC88_RS08000	COG0366	Alpha amylase catalytic
HYC88_RS08000	COG1470	cell adhesion involved in biofilm formation
HYC88_RS08055	COG1051	belongs to the nudix hydrolase family
HYC88_RS08070	COG0492	ferredoxin-NADP+ reductase activity
HYC88_RS08090	COG2207	Transcriptional regulator
HYC88_RS08090	COG3708	Transcriptional regulator
HYC88_RS08115	COG1472	Belongs to the glycosyl hydrolase 3 family
HYC88_RS08120	COG0444	Belongs to the ABC transporter superfamily
HYC88_RS08125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS08130	COG0601	transmembrane transport
HYC88_RS08145	COG1609	Transcriptional regulator
HYC88_RS08150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYC88_RS08160	COG2957	Belongs to the agmatine deiminase family
HYC88_RS08165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYC88_RS08170	COG0473	3-isopropylmalate dehydrogenase activity
HYC88_RS08190	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS08195	COG0506	proline dehydrogenase activity
HYC88_RS08205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYC88_RS08225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYC88_RS08230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYC88_RS08235	COG0440	acetolactate synthase activity
HYC88_RS08260	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS08275	COG3835	regulator
HYC88_RS08280	COG0667	Aldo Keto reductase
HYC88_RS08285	COG2133	pyrroloquinoline quinone binding
HYC88_RS08295	COG2197	response regulator
HYC88_RS08315	COG2409	Drug exporters of the RND superfamily
HYC88_RS08325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYC88_RS08330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYC88_RS08340	COG0154	amidase activity
HYC88_RS08345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYC88_RS08355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYC88_RS08365	COG4221	oxidoreductase activity
HYC88_RS08385	COG0482	sulfurtransferase activity
HYC88_RS08420	COG0789	Transcriptional regulator
HYC88_RS08430	COG2860	membrane
HYC88_RS08435	COG4608	Belongs to the ABC transporter superfamily
HYC88_RS08445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS08450	COG0601	transmembrane transport
HYC88_RS08455	COG4166	transmembrane transport
HYC88_RS08475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYC88_RS08480	COG0509	glycine decarboxylation via glycine cleavage system
HYC88_RS08485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYC88_RS08490	COG1760	l-serine dehydratase
HYC88_RS08500	COG0640	Transcriptional regulator
HYC88_RS08510	COG0464	growth
HYC88_RS08520	COG1506	peptidase
HYC88_RS08520	COG0823	Involved in the tonB-independent uptake of proteins
HYC88_RS08670	COG2197	response regulator
HYC88_RS08685	COG1131	(ABC) transporter
HYC88_RS08690	COG1132	(ABC) transporter
HYC88_RS08695	COG1132	(ABC) transporter
HYC88_RS08725	COG0058	SHG alpha-glucan phosphorylase activity
HYC88_RS08730	COG0366	Alpha amylase catalytic
HYC88_RS08735	COG0366	Alpha amylase catalytic
HYC88_RS08740	COG3281	Trehalose synthase
HYC88_RS08745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYC88_RS08755	COG3118	belongs to the thioredoxin family
HYC88_RS08770	COG1301	dicarboxylic acid transport
HYC88_RS08780	COG4565	transcriptional regulatory protein
HYC88_RS08790	COG0205	6-phosphofructokinase activity
HYC88_RS08795	COG0857	belongs to the CobB CobQ family
HYC88_RS08795	COG0280	phosphate acetyltransferase
HYC88_RS08800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYC88_RS08835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYC88_RS08835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYC88_RS08905	COG5000	phosphorelay sensor kinase activity
HYC88_RS08905	COG5002	protein histidine kinase activity
HYC88_RS08910	COG0745	RESPONSE REGULATOR receiver
HYC88_RS08925	COG0183	Belongs to the thiolase family
HYC88_RS08945	COG1131	(ABC) transporter
HYC88_RS08980	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HYC88_RS08995	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYC88_RS09010	COG4585	Histidine kinase
HYC88_RS09015	COG2197	response regulator
HYC88_RS09030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYC88_RS09035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYC88_RS09040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYC88_RS09045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYC88_RS09050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYC88_RS09055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYC88_RS09060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYC88_RS09080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYC88_RS09085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYC88_RS09095	COG2890	protein-(glutamine-N5) methyltransferase activity
HYC88_RS09100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYC88_RS09105	COG0254	rRNA binding
HYC88_RS09110	COG1316	TRANSCRIPTIONal
HYC88_RS09125	COG0083	homoserine kinase activity
HYC88_RS09130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYC88_RS09135	COG0460	homoserine dehydrogenase
HYC88_RS09140	COG0019	diaminopimelate decarboxylase activity
HYC88_RS09145	COG0018	arginyl-trna synthetase
HYC88_RS09240	COG3629	intracellular signal transduction
HYC88_RS09240	COG3903	Transcriptional regulator
HYC88_RS09250	COG3629	intracellular signal transduction
HYC88_RS09250	COG3903	Transcriptional regulator
HYC88_RS09265	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYC88_RS09270	COG3285	dna ligase
HYC88_RS09270	COG1793	dna ligase
HYC88_RS09290	COG2205	protein histidine kinase activity
HYC88_RS09305	COG0768	penicillin binding
HYC88_RS09340	COG1309	transcriptional regulator
HYC88_RS09400	COG0726	polysaccharide deacetylase
HYC88_RS09405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYC88_RS09415	COG0745	RESPONSE REGULATOR receiver
HYC88_RS09420	COG2205	protein histidine kinase activity
HYC88_RS09425	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYC88_RS09425	COG0567	Dehydrogenase, E1 component
HYC88_RS09450	COG0542	response to heat
HYC88_RS09470	COG0604	alcohol dehydrogenase
HYC88_RS09475	COG0281	malic enzyme
HYC88_RS09480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS09485	COG0765	amino acid transport
HYC88_RS09490	COG1126	abc transporter atp-binding protein
HYC88_RS09500	COG1595	DNA-templated transcription, initiation
HYC88_RS09505	COG4106	trans-aconitate 2-methyltransferase activity
HYC88_RS09575	COG4585	Histidine kinase
HYC88_RS09580	COG2197	response regulator
HYC88_RS09640	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYC88_RS09645	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYC88_RS09645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYC88_RS09690	COG0789	Transcriptional regulator
HYC88_RS09695	COG0431	NADPH-dependent FMN reductase
HYC88_RS09745	COG0477	Major facilitator Superfamily
HYC88_RS09770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYC88_RS09775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYC88_RS09815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS09830	COG1309	transcriptional regulator
HYC88_RS09845	COG4770	biotin carboxylase activity
HYC88_RS09885	COG0142	geranyltranstransferase activity
HYC88_RS09890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYC88_RS09895	COG1959	2 iron, 2 sulfur cluster binding
HYC88_RS09920	COG2172	sigma factor antagonist activity
HYC88_RS09935	COG1597	lipid kinase activity
HYC88_RS09950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYC88_RS09955	COG0363	glucosamine-6-phosphate deaminase activity
HYC88_RS09960	COG1472	Belongs to the glycosyl hydrolase 3 family
HYC88_RS09965	COG0395	ABC-type sugar transport system, permease component
HYC88_RS09970	COG1175	transmembrane transport
HYC88_RS09975	COG2182	Extracellular solute-binding protein
HYC88_RS09985	COG1966	Carbon starvation protein
HYC88_RS10015	COG1131	(ABC) transporter
HYC88_RS10060	COG0242	peptide deformylase activity
HYC88_RS10070	COG5662	AntiSigma factor
HYC88_RS10075	COG1595	DNA-templated transcription, initiation
HYC88_RS10085	COG2135	peptidase activity
HYC88_RS10095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYC88_RS10100	COG1162	GTPase activity
HYC88_RS10105	COG2076	Multidrug Resistance protein
HYC88_RS10115	COG0483	inositol monophosphate 1-phosphatase activity
HYC88_RS10125	COG0753	catalase activity
HYC88_RS10150	COG1615	UPF0182 protein
HYC88_RS10160	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYC88_RS10215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYC88_RS10260	COG0210	DNA helicase
HYC88_RS10320	COG0601	transmembrane transport
HYC88_RS10325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS10330	COG0747	negative chemotaxis
HYC88_RS10370	COG0513	Belongs to the DEAD box helicase family
HYC88_RS10385	COG1432	Conserved Protein
HYC88_RS10395	COG2095	MarC family integral membrane protein
HYC88_RS10410	COG2814	Major facilitator Superfamily
HYC88_RS10420	COG0598	Magnesium transport protein CorA
HYC88_RS10455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYC88_RS10460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYC88_RS10470	COG1595	DNA-templated transcription, initiation
HYC88_RS10485	COG1024	Enoyl-CoA hydratase
HYC88_RS10490	COG0519	Catalyzes the synthesis of GMP from XMP
HYC88_RS10500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYC88_RS10505	COG1611	Belongs to the LOG family
HYC88_RS10510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYC88_RS10540	COG2912	Transglutaminase-like superfamily
HYC88_RS10545	COG2197	response regulator
HYC88_RS10550	COG1132	(ABC) transporter
HYC88_RS10555	COG1132	(ABC) transporter
HYC88_RS10565	COG0515	serine threonine protein kinase
HYC88_RS10580	COG0110	maltose O-acetyltransferase activity
HYC88_RS10605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYC88_RS10625	COG4608	Belongs to the ABC transporter superfamily
HYC88_RS10635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS10640	COG0601	transmembrane transport
HYC88_RS10645	COG4166	transmembrane transport
HYC88_RS10650	COG4608	Belongs to the ABC transporter superfamily
HYC88_RS10655	COG0444	Belongs to the ABC transporter superfamily
HYC88_RS10660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS10665	COG0601	transmembrane transport
HYC88_RS10670	COG4166	transmembrane transport
HYC88_RS10675	COG1217	gtp-binding protein TYPA
HYC88_RS10685	COG1609	Transcriptional regulator
HYC88_RS10700	COG1175	transmembrane transport
HYC88_RS10705	COG0395	ABC-type sugar transport system, permease component
HYC88_RS10725	COG1073	alpha beta
HYC88_RS10730	COG1073	alpha beta
HYC88_RS10780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYC88_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS10840	COG1842	Phage shock protein A
HYC88_RS10920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYC88_RS10965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYC88_RS10975	COG1131	(ABC) transporter
HYC88_RS11055	COG2197	response regulator
HYC88_RS11085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HYC88_RS11090	COG0012	GTP binding
HYC88_RS11105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYC88_RS11115	COG1570	exodeoxyribonuclease VII activity
HYC88_RS11120	COG1722	exodeoxyribonuclease VII activity
HYC88_RS11125	COG0778	Nitroreductase
HYC88_RS11150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HYC88_RS11150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HYC88_RS11165	COG3321	synthase
HYC88_RS11165	COG0604	alcohol dehydrogenase
HYC88_RS11175	COG1362	aminopeptidase activity
HYC88_RS11200	COG0114	fumarate hydratase activity
HYC88_RS11235	COG1136	(ABC) transporter
HYC88_RS11250	COG0450	alkyl hydroperoxide reductase
HYC88_RS11255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYC88_RS11270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYC88_RS11275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYC88_RS11280	COG0667	Aldo Keto reductase
HYC88_RS11340	COG2885	chlorophyll binding
HYC88_RS11360	COG2197	response regulator
HYC88_RS11365	COG3920	Histidine kinase
HYC88_RS11395	COG2894	cell division
HYC88_RS11420	COG2610	gluconate transmembrane transporter activity
HYC88_RS11425	COG0251	oxidation-reduction process
HYC88_RS11430	COG1414	Transcriptional regulator
HYC88_RS11445	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HYC88_RS11455	COG1733	regulation of RNA biosynthetic process
HYC88_RS11475	COG0436	Aminotransferase
HYC88_RS11505	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HYC88_RS11515	COG1331	Highly conserved protein containing a thioredoxin domain
HYC88_RS11535	COG1518	maintenance of DNA repeat elements
HYC88_RS11540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYC88_RS11575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYC88_RS11585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYC88_RS11605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYC88_RS11640	COG0583	DNA-binding transcription factor activity
HYC88_RS11645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYC88_RS11675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYC88_RS11695	COG2746	aminoglycoside 3-N-acetyltransferase activity
HYC88_RS11700	COG1376	ErfK ybiS ycfS ynhG family protein
HYC88_RS11730	COG1024	Enoyl-CoA hydratase
HYC88_RS11745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYC88_RS11755	COG0424	maF-like protein
HYC88_RS11765	COG4770	biotin carboxylase activity
HYC88_RS11795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYC88_RS11810	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS11815	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS11835	COG1595	DNA-templated transcription, initiation
HYC88_RS11840	COG0745	RESPONSE REGULATOR receiver
HYC88_RS11845	COG2205	protein histidine kinase activity
HYC88_RS11870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYC88_RS11885	COG0583	DNA-binding transcription factor activity
HYC88_RS11890	COG2814	Major facilitator Superfamily
HYC88_RS11895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYC88_RS11925	COG1404	Belongs to the peptidase S8 family
HYC88_RS11945	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYC88_RS11950	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYC88_RS11955	COG3845	ABC transporter
HYC88_RS11960	COG1744	ABC transporter substrate-binding protein PnrA-like
HYC88_RS11965	COG1473	amidohydrolase
HYC88_RS11965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HYC88_RS11980	COG2089	acid synthase
HYC88_RS11985	COG1083	cytidylyl-transferase
HYC88_RS11995	COG1216	Glycosyl transferase, family 2
HYC88_RS12025	COG1216	Glycosyl transferase, family 2
HYC88_RS12050	COG1595	DNA-templated transcription, initiation
HYC88_RS12085	COG2003	Belongs to the UPF0758 family
HYC88_RS12110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HYC88_RS12115	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HYC88_RS12120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HYC88_RS12135	COG0531	amino acid
HYC88_RS12140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HYC88_RS12175	COG2009	succinate dehydrogenase
HYC88_RS12190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYC88_RS12220	COG1408	metallophosphoesterase
HYC88_RS12230	COG1295	ribonuclease BN
HYC88_RS12250	COG0180	Tryptophanyl-tRNA synthetase
HYC88_RS12255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYC88_RS12260	COG0754	glutathionylspermidine amidase activity
HYC88_RS12270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYC88_RS12275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYC88_RS12280	COG0039	L-malate dehydrogenase activity
HYC88_RS12295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYC88_RS12310	COG0138	bifunctional purine biosynthesis protein purh
HYC88_RS12340	COG0045	succinate-CoA ligase (ADP-forming) activity
HYC88_RS12355	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HYC88_RS12365	COG0714	Associated with various cellular activities
HYC88_RS12385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYC88_RS12395	COG0739	heme binding
HYC88_RS12425	COG2197	response regulator
HYC88_RS12460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYC88_RS12465	COG0519	Catalyzes the synthesis of GMP from XMP
HYC88_RS12465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYC88_RS12485	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS12490	COG0515	serine threonine protein kinase
HYC88_RS12490	COG2815	serine threonine protein kinase
HYC88_RS12495	COG0515	serine threonine protein kinase
HYC88_RS12525	COG0516	GMP reductase activity
HYC88_RS12535	COG1595	DNA-templated transcription, initiation
HYC88_RS12550	COG0583	DNA-binding transcription factor activity
HYC88_RS12565	COG2132	Multicopper oxidase
HYC88_RS12570	COG4221	oxidoreductase activity
HYC88_RS12580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYC88_RS12590	COG0726	polysaccharide deacetylase
HYC88_RS12625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYC88_RS12650	COG0802	atpase or kinase
HYC88_RS12660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYC88_RS12665	COG3189	MarR family transcriptional regulator
HYC88_RS12675	COG0736	holo-[acyl-carrier-protein] synthase activity
HYC88_RS12680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYC88_RS12705	COG4941	Belongs to the sigma-70 factor family
HYC88_RS12710	COG3795	YCII-related domain
HYC88_RS12790	COG1072	(Pantothenic acid kinase))
HYC88_RS12800	COG2208	phosphoserine phosphatase activity
HYC88_RS12800	COG2770	Histidine kinase
HYC88_RS12805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYC88_RS12810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYC88_RS12815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYC88_RS12820	COG0488	(ABC) transporter
HYC88_RS12830	COG0101	tRNA pseudouridine synthase activity
HYC88_RS12835	COG0203	ribosomal protein L17
HYC88_RS12840	COG0202	RNA polymerase activity
HYC88_RS12845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYC88_RS12850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYC88_RS12855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYC88_RS12860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYC88_RS12870	COG0563	adenylate kinase activity
HYC88_RS12880	COG0200	Binds to the 23S rRNA
HYC88_RS12885	COG1841	ribosomal large subunit assembly
HYC88_RS12890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYC88_RS12895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYC88_RS12900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYC88_RS12905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYC88_RS12910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYC88_RS12915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYC88_RS12920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYC88_RS12925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYC88_RS12930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYC88_RS12935	COG0255	Belongs to the universal ribosomal protein uL29 family
HYC88_RS12940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYC88_RS12945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYC88_RS12950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYC88_RS12955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYC88_RS12960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYC88_RS12965	COG0089	rRNA binding
HYC88_RS12970	COG0088	Forms part of the polypeptide exit tunnel
HYC88_RS12975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYC88_RS12980	COG0051	transcription antitermination factor activity, RNA binding
HYC88_RS12995	COG2197	response regulator
HYC88_RS13015	COG4585	Histidine kinase
HYC88_RS13020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYC88_RS13025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYC88_RS13030	COG0049	tRNA binding
HYC88_RS13035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYC88_RS13040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYC88_RS13045	COG0085	RNA polymerase activity
HYC88_RS13050	COG0222	ribosome binding
HYC88_RS13055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYC88_RS13065	COG0081	regulation of translation
HYC88_RS13070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYC88_RS13090	COG0436	Aminotransferase
HYC88_RS13095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYC88_RS13110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYC88_RS13115	COG0477	Major facilitator Superfamily
HYC88_RS13125	COG2030	dehydratase
HYC88_RS13130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYC88_RS13150	COG0702	epimerase
HYC88_RS13160	COG1666	GTP binding
HYC88_RS13165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYC88_RS13180	COG3304	Inner membrane component domain
HYC88_RS13185	COG0501	Belongs to the peptidase M48B family
HYC88_RS13190	COG1970	mechanosensitive ion channel activity
HYC88_RS13195	COG1007	ATP synthesis coupled electron transport
HYC88_RS13210	COG0713	ATP synthesis coupled electron transport
HYC88_RS13215	COG0839	Belongs to the complex I subunit 6 family
HYC88_RS13220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYC88_RS13225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYC88_RS13235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYC88_RS13240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYC88_RS13260	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYC88_RS13260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYC88_RS13265	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYC88_RS13270	COG1733	regulation of RNA biosynthetic process
HYC88_RS13275	COG0702	epimerase
HYC88_RS13345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYC88_RS13350	COG0561	phosphatase activity
HYC88_RS13375	COG4133	protoheme IX ABC transporter activity
HYC88_RS13400	COG1131	(ABC) transporter
HYC88_RS13410	COG0142	geranyltranstransferase activity
HYC88_RS13415	COG3104	oligopeptide transport
HYC88_RS13425	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYC88_RS13445	COG1007	ATP synthesis coupled electron transport
HYC88_RS13455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYC88_RS13460	COG0713	ATP synthesis coupled electron transport
HYC88_RS13465	COG0839	Belongs to the complex I subunit 6 family
HYC88_RS13470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYC88_RS13475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYC88_RS13480	COG1034	ATP synthesis coupled electron transport
HYC88_RS13485	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HYC88_RS13495	COG0649	NAD binding
HYC88_RS13500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYC88_RS13505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYC88_RS13540	COG2226	methyltransferase
HYC88_RS13565	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYC88_RS13575	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HYC88_RS13580	COG1278	Cold shock
HYC88_RS13585	COG4608	Belongs to the ABC transporter superfamily
HYC88_RS13595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS13600	COG0601	transmembrane transport
HYC88_RS13605	COG4166	transmembrane transport
HYC88_RS13665	COG1024	Enoyl-CoA hydratase
HYC88_RS13690	COG1309	transcriptional regulator
HYC88_RS13700	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS13725	COG0501	Belongs to the peptidase M48B family
HYC88_RS13770	COG2072	flavoprotein involved in K transport
HYC88_RS13805	COG1024	Enoyl-CoA hydratase
HYC88_RS13810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYC88_RS13825	COG0346	lactoylglutathione lyase activity
HYC88_RS13835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYC88_RS13935	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS13955	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS13960	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS13970	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS13980	COG1366	Belongs to the anti-sigma-factor antagonist family
HYC88_RS14035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYC88_RS14045	COG4821	SIS domain
HYC88_RS14060	COG0259	pyridoxamine-phosphate oxidase activity
HYC88_RS14085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYC88_RS14115	COG2318	DinB family
HYC88_RS14135	COG0456	acetyltransferase
HYC88_RS14170	COG1024	Enoyl-CoA hydratase
HYC88_RS14175	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS14190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYC88_RS14205	COG1309	transcriptional regulator
HYC88_RS14220	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HYC88_RS14225	COG5006	permease, DMT superfamily
HYC88_RS14230	COG0583	DNA-binding transcription factor activity
HYC88_RS14235	COG0277	FAD linked oxidase domain protein
HYC88_RS14235	COG0247	lactate metabolic process
HYC88_RS14240	COG2205	protein histidine kinase activity
HYC88_RS14270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HYC88_RS14285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYC88_RS14295	COG1335	isochorismatase
HYC88_RS14375	COG1309	transcriptional regulator
HYC88_RS14385	COG2205	protein histidine kinase activity
HYC88_RS14390	COG0745	RESPONSE REGULATOR receiver
HYC88_RS14410	COG1136	(ABC) transporter
HYC88_RS14410	COG0577	efflux transmembrane transporter activity
HYC88_RS14525	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS14530	COG0515	serine threonine protein kinase
HYC88_RS14550	COG0667	Aldo Keto reductase
HYC88_RS14575	COG2252	PERMEase
HYC88_RS14585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYC88_RS14610	COG2814	Major facilitator Superfamily
HYC88_RS14620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYC88_RS14625	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HYC88_RS14635	COG1278	Cold shock
HYC88_RS14650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS14655	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS14660	COG1120	ATPase activity
HYC88_RS14665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYC88_RS14695	COG1061	Type III restriction enzyme res subunit
HYC88_RS14705	COG3973	AAA domain
HYC88_RS14720	COG1984	allophanate hydrolase subunit 2
HYC88_RS14730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HYC88_RS14760	COG1737	Transcriptional regulator
HYC88_RS14765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYC88_RS14820	COG1175	transmembrane transport
HYC88_RS14825	COG0395	ABC-type sugar transport system, permease component
HYC88_RS14850	COG0604	alcohol dehydrogenase
HYC88_RS14850	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS14850	COG3321	synthase
HYC88_RS14880	COG1595	DNA-templated transcription, initiation
HYC88_RS14890	COG1132	(ABC) transporter
HYC88_RS14915	COG0463	Glycosyl transferase, family 2
HYC88_RS14920	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HYC88_RS14930	COG0577	efflux transmembrane transporter activity
HYC88_RS14935	COG1136	(ABC) transporter
HYC88_RS14935	COG0577	efflux transmembrane transporter activity
HYC88_RS14940	COG4585	Histidine kinase
HYC88_RS14945	COG2197	response regulator
HYC88_RS14950	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HYC88_RS14985	COG2197	response regulator
HYC88_RS15040	COG1132	(ABC) transporter
HYC88_RS15045	COG1132	(ABC) transporter
HYC88_RS15050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS15065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYC88_RS15195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYC88_RS15200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYC88_RS15205	COG1754	DNA topoisomerase type I activity
HYC88_RS15205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYC88_RS15215	COG2890	protein-(glutamine-N5) methyltransferase activity
HYC88_RS15225	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYC88_RS15235	COG1366	Belongs to the anti-sigma-factor antagonist family
HYC88_RS15240	COG1111	helicase
HYC88_RS15240	COG1205	dead DEAH box helicase
HYC88_RS15245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYC88_RS15305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYC88_RS15310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYC88_RS15320	COG2267	carboxylic ester hydrolase activity
HYC88_RS15345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYC88_RS15355	COG0251	oxidation-reduction process
HYC88_RS15370	COG0003	Pfam Anion-transporting ATPase
HYC88_RS15380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYC88_RS15385	COG1610	YqeY-like protein
HYC88_RS15390	COG1408	metallophosphoesterase
HYC88_RS15415	COG3629	intracellular signal transduction
HYC88_RS15415	COG3903	Transcriptional regulator
HYC88_RS15425	COG1609	Transcriptional regulator
HYC88_RS15460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HYC88_RS15485	COG0515	serine threonine protein kinase
HYC88_RS15485	COG2815	serine threonine protein kinase
HYC88_RS15510	COG0492	ferredoxin-NADP+ reductase activity
HYC88_RS15585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYC88_RS15585	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HYC88_RS15590	COG0653	protein targeting
HYC88_RS15600	COG2755	lipolytic protein G-D-S-L family
HYC88_RS15610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HYC88_RS15630	COG1595	DNA-templated transcription, initiation
HYC88_RS15655	COG0702	epimerase
HYC88_RS15665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYC88_RS15670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYC88_RS15685	COG1802	Transcriptional regulator
HYC88_RS15690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYC88_RS15695	COG0693	protein deglycase activity
HYC88_RS15725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYC88_RS15730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYC88_RS15730	COG0515	serine threonine protein kinase
HYC88_RS15735	COG0738	Major facilitator superfamily
HYC88_RS15740	COG3226	Transcriptional regulator
HYC88_RS15750	COG0667	Aldo Keto reductase
HYC88_RS15775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS15785	COG0662	Cupin 2, conserved barrel domain protein
HYC88_RS15790	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS15865	COG0590	tRNA wobble adenosine to inosine editing
HYC88_RS15870	COG1902	pentaerythritol trinitrate reductase activity
HYC88_RS15875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYC88_RS15905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYC88_RS15910	COG0142	geranyltranstransferase activity
HYC88_RS15915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYC88_RS15920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYC88_RS15930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYC88_RS15940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS15960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS15965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYC88_RS15970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYC88_RS15975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYC88_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS16035	COG4106	trans-aconitate 2-methyltransferase activity
HYC88_RS16080	COG3903	Transcriptional regulator
HYC88_RS16080	COG3629	intracellular signal transduction
HYC88_RS16105	COG0592	DNA-directed DNA polymerase activity
HYC88_RS16140	COG3403	YqcI/YcgG family
HYC88_RS16155	COG1021	2,3-dihydroxybenzoate-AMP ligase
HYC88_RS16160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS16170	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS16180	COG2267	carboxylic ester hydrolase activity
HYC88_RS16185	COG1132	(ABC) transporter
HYC88_RS16190	COG2375	cellular response to nickel ion
HYC88_RS16190	COG1132	(ABC) transporter
HYC88_RS16215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYC88_RS16235	COG2124	cytochrome p450
HYC88_RS16240	COG2197	response regulator
HYC88_RS16245	COG4585	Histidine kinase
HYC88_RS16260	COG3844	kynureninase activity
HYC88_RS16275	COG0477	Major facilitator Superfamily
HYC88_RS16280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYC88_RS16285	COG0191	fructose-bisphosphate aldolase activity
HYC88_RS16290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYC88_RS16305	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYC88_RS16330	COG0542	response to heat
HYC88_RS16360	COG0789	Transcriptional regulator
HYC88_RS16365	COG0484	heat shock protein binding
HYC88_RS16370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYC88_RS16375	COG0443	Heat shock 70 kDa protein
HYC88_RS16380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYC88_RS16385	COG2181	nitrate reductase activity
HYC88_RS16385	COG0247	lactate metabolic process
HYC88_RS16405	COG0717	Belongs to the dCTP deaminase family
HYC88_RS16510	COG3226	Transcriptional regulator
HYC88_RS16515	COG1309	transcriptional regulator
HYC88_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS16555	COG2205	protein histidine kinase activity
HYC88_RS16560	COG0745	RESPONSE REGULATOR receiver
HYC88_RS16575	COG1695	Transcriptional regulator
HYC88_RS16590	COG1609	Transcriptional regulator
HYC88_RS16615	COG2124	cytochrome p450
HYC88_RS16620	COG2124	cytochrome p450
HYC88_RS16645	COG3585	molybdate ion transport
HYC88_RS16670	COG0531	amino acid
HYC88_RS16680	COG0475	glutathione-regulated potassium exporter activity
HYC88_RS16685	COG2409	Drug exporters of the RND superfamily
HYC88_RS16690	COG3594	Acyltransferase
HYC88_RS16705	COG0513	Belongs to the DEAD box helicase family
HYC88_RS16710	COG1278	Cold shock
HYC88_RS16760	COG0450	alkyl hydroperoxide reductase
HYC88_RS16770	COG2268	Band 7 protein
HYC88_RS16840	COG0490	domain, Protein
HYC88_RS16845	COG0475	glutathione-regulated potassium exporter activity
HYC88_RS16870	COG2255	four-way junction helicase activity
HYC88_RS16880	COG0180	Tryptophanyl-tRNA synthetase
HYC88_RS16890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS16905	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYC88_RS16905	COG1672	PFAM Archaeal ATPase
HYC88_RS16925	COG0431	NADPH-dependent FMN reductase
HYC88_RS16955	COG2304	oxidoreductase activity
HYC88_RS16960	COG2205	protein histidine kinase activity
HYC88_RS16965	COG0745	RESPONSE REGULATOR receiver
HYC88_RS16970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYC88_RS16985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYC88_RS17000	COG1741	Belongs to the pirin family
HYC88_RS17010	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS17015	COG1362	aminopeptidase activity
HYC88_RS17050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYC88_RS17075	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYC88_RS17080	COG0022	dehydrogenase e1 component
HYC88_RS17105	COG0515	serine threonine protein kinase
HYC88_RS17110	COG0515	serine threonine protein kinase
HYC88_RS17125	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYC88_RS17125	COG1136	(ABC) transporter
HYC88_RS17175	COG1522	sequence-specific DNA binding
HYC88_RS17180	COG1309	transcriptional regulator
HYC88_RS17205	COG3396	Phenylacetate-CoA oxygenase
HYC88_RS17210	COG3460	Phenylacetate-CoA oxygenase
HYC88_RS17215	COG3396	Phenylacetate-CoA oxygenase
HYC88_RS17220	COG2151	metal-sulfur cluster biosynthetic enzyme
HYC88_RS17225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYC88_RS17250	COG1733	regulation of RNA biosynthetic process
HYC88_RS17265	COG1716	ATPase activity
HYC88_RS17270	COG1716	ATPase activity
HYC88_RS17285	COG0768	penicillin binding
HYC88_RS17290	COG0515	serine threonine protein kinase
HYC88_RS17295	COG3764	Sortase (surface protein transpeptidase)
HYC88_RS17300	COG3764	Sortase (surface protein transpeptidase)
HYC88_RS17315	COG3764	Sortase (surface protein transpeptidase)
HYC88_RS17330	COG0705	Rhomboid family
HYC88_RS17360	COG0515	serine threonine protein kinase
HYC88_RS17395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYC88_RS17405	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HYC88_RS17410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYC88_RS17415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HYC88_RS17420	COG0592	DNA-directed DNA polymerase activity
HYC88_RS17430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYC88_RS17435	COG0594	ribonuclease P activity
HYC88_RS17440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYC88_RS17445	COG0706	membrane insertase activity
HYC88_RS17455	COG0357	Ribosomal RNA small subunit methyltransferase G
HYC88_RS17460	COG1192	Involved in chromosome partitioning
HYC88_RS17475	COG3118	belongs to the thioredoxin family
HYC88_RS17480	COG0492	ferredoxin-NADP+ reductase activity
HYC88_RS17490	COG1595	DNA-templated transcription, initiation
HYC88_RS17495	COG2815	serine threonine protein kinase
HYC88_RS17495	COG0515	serine threonine protein kinase
HYC88_RS17510	COG0617	tRNA 3'-terminal CCA addition
HYC88_RS17530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYC88_RS17555	COG0360	Binds together with S18 to 16S ribosomal RNA
HYC88_RS17560	COG0629	single-stranded DNA binding
HYC88_RS17565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYC88_RS17570	COG0359	binds to the 23S rRNA
HYC88_RS17580	COG0305	Participates in initiation and elongation during chromosome replication
HYC88_RS17615	COG2814	Major facilitator Superfamily
HYC88_RS17635	COG0626	cystathionine gamma-synthase activity
HYC88_RS17640	COG1950	PFAM Membrane protein of
HYC88_RS17645	COG0662	Cupin 2, conserved barrel domain protein
HYC88_RS17670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HYC88_RS17675	COG3152	Membrane
HYC88_RS17685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYC88_RS17690	COG1609	Transcriptional regulator
HYC88_RS17695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYC88_RS17700	COG1271	oxidase subunit
HYC88_RS17705	COG1294	oxidase, subunit
HYC88_RS17710	COG4988	ABC transporter
HYC88_RS17720	COG0561	phosphatase activity
HYC88_RS17730	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HYC88_RS17735	COG0789	Transcriptional regulator
HYC88_RS17755	COG1131	(ABC) transporter
HYC88_RS17780	COG0561	phosphatase activity
HYC88_RS17785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYC88_RS17795	COG2837	iron assimilation
HYC88_RS17800	COG2372	response to copper ion
HYC88_RS17810	COG1999	signal sequence binding
HYC88_RS17830	COG0006	proline dipeptidase activity
HYC88_RS17845	COG0653	protein targeting
HYC88_RS17860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYC88_RS17880	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS17885	COG2030	dehydratase
HYC88_RS17905	COG1595	DNA-templated transcription, initiation
HYC88_RS17910	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS17945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYC88_RS17960	COG0494	nUDIX hydrolase
HYC88_RS17975	COG1252	NADH dehydrogenase
HYC88_RS17980	COG1595	DNA-templated transcription, initiation
HYC88_RS18015	COG0745	RESPONSE REGULATOR receiver
HYC88_RS18020	COG2205	protein histidine kinase activity
HYC88_RS18030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HYC88_RS18045	COG0477	Major facilitator Superfamily
HYC88_RS18060	COG3467	pyridoxamine 5'-phosphate
HYC88_RS18065	COG2353	YceI-like domain
HYC88_RS18090	COG1191	sigma factor activity
HYC88_RS18095	COG1191	sigma factor activity
HYC88_RS18120	COG1518	maintenance of DNA repeat elements
HYC88_RS18170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYC88_RS18175	COG0583	DNA-binding transcription factor activity
HYC88_RS18180	COG0251	oxidation-reduction process
HYC88_RS18205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYC88_RS18255	COG0464	growth
HYC88_RS18345	COG4941	Belongs to the sigma-70 factor family
HYC88_RS18385	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HYC88_RS18405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYC88_RS18495	COG0492	ferredoxin-NADP+ reductase activity
HYC88_RS18515	COG0151	Belongs to the GarS family
HYC88_RS18530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYC88_RS18540	COG2197	response regulator
HYC88_RS18575	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYC88_RS18580	COG0047	phosphoribosylformylglycinamidine synthase activity
HYC88_RS18585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYC88_RS18595	COG0741	lytic transglycosylase activity
HYC88_RS18595	COG0739	heme binding
HYC88_RS18595	COG1196	nuclear chromosome segregation
HYC88_RS18610	COG3119	arylsulfatase activity
HYC88_RS18620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYC88_RS18655	COG1643	Atp-dependent helicase
HYC88_RS18665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYC88_RS18665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HYC88_RS18670	COG0785	Cytochrome C biogenesis protein
HYC88_RS18700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYC88_RS18705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYC88_RS18715	COG0513	Belongs to the DEAD box helicase family
HYC88_RS18745	COG2319	Wd-40 repeat
HYC88_RS18745	COG4249	Peptidase C14 caspase catalytic subunit p20
HYC88_RS18760	COG0789	Transcriptional regulator
HYC88_RS18770	COG0741	lytic transglycosylase activity
HYC88_RS18770	COG1196	nuclear chromosome segregation
HYC88_RS18770	COG0739	heme binding
HYC88_RS18785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYC88_RS18790	COG0579	oxidoreductase
HYC88_RS18815	COG1252	NADH dehydrogenase
HYC88_RS18830	COG1846	Transcriptional regulator
HYC88_RS18850	COG2197	response regulator
HYC88_RS18855	COG4585	Histidine kinase
HYC88_RS18865	COG1131	(ABC) transporter
HYC88_RS18925	COG0739	heme binding
HYC88_RS18925	COG1196	nuclear chromosome segregation
HYC88_RS18925	COG0741	lytic transglycosylase activity
HYC88_RS18930	COG0671	phosphoesterase, PA-phosphatase related
HYC88_RS18950	COG1937	Protein conserved in bacteria
HYC88_RS18960	COG0306	phosphate transporter
HYC88_RS18980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYC88_RS18985	COG0494	nUDIX hydrolase
HYC88_RS18985	COG0406	alpha-ribazole phosphatase activity
HYC88_RS19005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HYC88_RS19010	COG1725	Transcriptional regulator
HYC88_RS19015	COG0456	acetyltransferase
HYC88_RS19020	COG0737	Belongs to the 5'-nucleotidase family
HYC88_RS19045	COG1595	DNA-templated transcription, initiation
HYC88_RS19075	COG0739	heme binding
HYC88_RS19095	COG1902	pentaerythritol trinitrate reductase activity
HYC88_RS19100	COG0823	Involved in the tonB-independent uptake of proteins
HYC88_RS19105	COG3311	Transcriptional regulator
HYC88_RS19125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYC88_RS19130	COG1609	Transcriptional regulator
HYC88_RS19135	COG0745	RESPONSE REGULATOR receiver
HYC88_RS19160	COG2897	thiosulfate sulfurtransferase activity
HYC88_RS19195	COG3485	protocatechuate 3,4-dioxygenase
HYC88_RS19210	COG1490	D-aminoacyl-tRNA deacylase activity
HYC88_RS19225	COG4552	Acetyltransferase involved in intracellular survival and related
HYC88_RS19260	COG4942	peptidase
HYC88_RS19310	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS19345	COG4106	trans-aconitate 2-methyltransferase activity
HYC88_RS19395	COG0588	phosphoglycerate mutase activity
HYC88_RS19415	COG5002	protein histidine kinase activity
HYC88_RS19430	COG1329	Transcriptional regulator
HYC88_RS19435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYC88_RS19440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYC88_RS19465	COG3467	pyridoxamine 5'-phosphate
HYC88_RS19470	COG0215	cysteine-tRNA ligase activity
HYC88_RS19475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYC88_RS19495	COG3842	ATPase activity
HYC88_RS19540	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS19575	COG0604	alcohol dehydrogenase
HYC88_RS19575	COG3321	synthase
HYC88_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS19585	COG0477	Major facilitator Superfamily
HYC88_RS19590	COG2345	Transcriptional regulator
HYC88_RS19595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYC88_RS19615	COG0367	asparagine synthase
HYC88_RS19620	COG3903	Transcriptional regulator
HYC88_RS19620	COG3629	intracellular signal transduction
HYC88_RS19630	COG0662	Cupin 2, conserved barrel domain protein
HYC88_RS19635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS19640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS19655	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS19670	COG2124	cytochrome p450
HYC88_RS19700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYC88_RS19740	COG2197	response regulator
HYC88_RS19745	COG4585	Histidine kinase
HYC88_RS19755	COG0666	response to abiotic stimulus
HYC88_RS19780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYC88_RS19805	COG1105	Belongs to the carbohydrate kinase PfkB family
HYC88_RS19810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYC88_RS19845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYC88_RS19845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYC88_RS19885	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS19890	COG3629	intracellular signal transduction
HYC88_RS19905	COG0736	holo-[acyl-carrier-protein] synthase activity
HYC88_RS19930	COG1917	Cupin 2, conserved barrel domain protein
HYC88_RS19935	COG0456	acetyltransferase
HYC88_RS19940	COG5285	phytanoyl-CoA dioxygenase
HYC88_RS19950	COG2271	Major facilitator Superfamily
HYC88_RS19985	COG0076	glutamate decarboxylase activity
HYC88_RS19990	COG0655	NAD(P)H dehydrogenase (quinone) activity
HYC88_RS20000	COG0393	Putative heavy-metal-binding
HYC88_RS20005	COG0586	Pfam SNARE associated Golgi protein
HYC88_RS20015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYC88_RS20020	COG2027	D-alanyl-D-alanine carboxypeptidase
HYC88_RS20030	COG0037	tRNA processing
HYC88_RS20045	COG0302	gtp cyclohydrolase
HYC88_RS20065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HYC88_RS20080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYC88_RS20080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HYC88_RS20095	COG1174	glycine betaine transport
HYC88_RS20100	COG1174	glycine betaine transport
HYC88_RS20105	COG1732	Glycine betaine
HYC88_RS20115	COG0649	NAD binding
HYC88_RS20130	COG2197	response regulator
HYC88_RS20150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYC88_RS20155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYC88_RS20165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYC88_RS20185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HYC88_RS20215	COG0739	heme binding
HYC88_RS20220	COG2205	protein histidine kinase activity
HYC88_RS20225	COG0745	RESPONSE REGULATOR receiver
HYC88_RS20235	COG1595	DNA-templated transcription, initiation
HYC88_RS20240	COG1194	a g-specific adenine glycosylase
HYC88_RS20250	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HYC88_RS20270	COG0248	Ppx GppA phosphatase
HYC88_RS20275	COG1082	Xylose isomerase domain protein TIM barrel
HYC88_RS20285	COG0129	dihydroxy-acid dehydratase activity
HYC88_RS20290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYC88_RS20290	COG0515	serine threonine protein kinase
HYC88_RS20295	COG4991	sh3 domain protein
HYC88_RS20305	COG0842	Transport permease protein
HYC88_RS20305	COG1129	ABC transporter
HYC88_RS20310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYC88_RS20330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYC88_RS20335	COG2223	nitrite transmembrane transporter activity
HYC88_RS20390	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYC88_RS20395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYC88_RS20400	COG0181	hydroxymethylbilane synthase activity
HYC88_RS20405	COG1648	precorrin-2 dehydrogenase activity
HYC88_RS20405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYC88_RS20410	COG0113	porphobilinogen synthase activity
HYC88_RS20445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYC88_RS20490	COG0018	arginyl-trna synthetase
HYC88_RS20495	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HYC88_RS20520	COG1690	Belongs to the RtcB family
HYC88_RS20530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYC88_RS20555	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HYC88_RS20565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYC88_RS20570	COG0406	alpha-ribazole phosphatase activity
HYC88_RS20590	COG0785	Cytochrome C biogenesis protein
HYC88_RS20595	COG1333	cytochrome c biogenesis protein
HYC88_RS20600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYC88_RS20610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HYC88_RS20615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYC88_RS20625	COG0163	prenyltransferase activity
HYC88_RS20640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYC88_RS20655	COG1301	dicarboxylic acid transport
HYC88_RS20665	COG1309	transcriptional regulator
HYC88_RS20670	COG3647	Membrane
HYC88_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS20705	COG0741	lytic transglycosylase activity
HYC88_RS20705	COG1196	nuclear chromosome segregation
HYC88_RS20705	COG0739	heme binding
HYC88_RS20745	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HYC88_RS20780	COG0768	penicillin binding
HYC88_RS20790	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYC88_RS20795	COG2226	methyltransferase
HYC88_RS20800	COG0667	Aldo Keto reductase
HYC88_RS20840	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS20890	COG1686	Belongs to the peptidase S11 family
HYC88_RS20910	COG2409	Drug exporters of the RND superfamily
HYC88_RS20975	COG2175	clavaminate synthase activity
HYC88_RS20990	COG0019	diaminopimelate decarboxylase activity
HYC88_RS20995	COG0626	cystathionine gamma-synthase activity
HYC88_RS21005	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS21020	COG0516	GMP reductase activity
HYC88_RS21020	COG0517	IMP dehydrogenase activity
HYC88_RS21070	COG4607	ABC-type enterochelin transport system periplasmic component
HYC88_RS21095	COG1846	Transcriptional regulator
HYC88_RS21100	COG3384	dioxygenase
HYC88_RS21120	COG0477	Major facilitator Superfamily
HYC88_RS21145	COG0243	molybdopterin cofactor binding
HYC88_RS21150	COG0437	4 iron, 4 sulfur cluster binding
HYC88_RS21170	COG1970	mechanosensitive ion channel activity
HYC88_RS21180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HYC88_RS21205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYC88_RS21210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYC88_RS21220	COG0315	cyclic pyranopterin monophosphate synthase activity
HYC88_RS21225	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYC88_RS21230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYC88_RS21270	COG0708	Exodeoxyribonuclease III
HYC88_RS21280	COG2072	flavoprotein involved in K transport
HYC88_RS21290	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS21300	COG4946	Tricorn protease homolog
HYC88_RS21300	COG0793	Belongs to the peptidase S41A family
HYC88_RS21310	COG2409	Drug exporters of the RND superfamily
HYC88_RS21345	COG1122	ATPase activity
HYC88_RS21350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYC88_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS21375	COG0181	hydroxymethylbilane synthase activity
HYC88_RS21430	COG1115	amino acid carrier protein
HYC88_RS21440	COG0442	prolyl-tRNA aminoacylation
HYC88_RS21445	COG2207	Transcriptional regulator
HYC88_RS21450	COG2223	nitrite transmembrane transporter activity
HYC88_RS21480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYC88_RS21510	COG0084	hydrolase, TatD family'
HYC88_RS21515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYC88_RS21520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYC88_RS21540	COG0488	(ABC) transporter
HYC88_RS21575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYC88_RS21585	COG2197	response regulator
HYC88_RS21590	COG1846	Transcriptional regulator
HYC88_RS21595	COG4106	trans-aconitate 2-methyltransferase activity
HYC88_RS21615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYC88_RS21625	COG0193	aminoacyl-tRNA hydrolase activity
HYC88_RS21630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYC88_RS21635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYC88_RS21640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYC88_RS21655	COG4585	Histidine kinase
HYC88_RS21685	COG2124	cytochrome p450
HYC88_RS21690	COG2124	cytochrome p450
HYC88_RS21730	COG0346	lactoylglutathione lyase activity
HYC88_RS21735	COG0640	Transcriptional regulator
HYC88_RS21800	COG0477	Major facilitator Superfamily
HYC88_RS21805	COG1136	(ABC) transporter
HYC88_RS21810	COG0577	efflux transmembrane transporter activity
HYC88_RS21870	COG1335	isochorismatase
HYC88_RS21910	COG2124	cytochrome p450
HYC88_RS21925	COG0148	phosphopyruvate hydratase activity
HYC88_RS21945	COG1252	NADH dehydrogenase
HYC88_RS21950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYC88_RS21955	COG1136	(ABC) transporter
HYC88_RS21955	COG0577	efflux transmembrane transporter activity
HYC88_RS21960	COG0577	efflux transmembrane transporter activity
HYC88_RS21960	COG1136	(ABC) transporter
HYC88_RS21985	COG0183	Belongs to the thiolase family
HYC88_RS21990	COG2755	lipolytic protein G-D-S-L family
HYC88_RS22040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYC88_RS22055	COG1228	amidohydrolase
HYC88_RS22060	COG1191	sigma factor activity
HYC88_RS22065	COG1366	Belongs to the anti-sigma-factor antagonist family
HYC88_RS22100	COG3104	oligopeptide transport
HYC88_RS22105	COG0745	RESPONSE REGULATOR receiver
HYC88_RS22110	COG2205	protein histidine kinase activity
HYC88_RS22135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYC88_RS22165	COG2226	methyltransferase
HYC88_RS22195	COG1316	TRANSCRIPTIONal
HYC88_RS22205	COG1316	TRANSCRIPTIONal
HYC88_RS22220	COG1316	TRANSCRIPTIONal
HYC88_RS22225	COG1316	TRANSCRIPTIONal
HYC88_RS22250	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HYC88_RS22250	COG0778	Nitroreductase
HYC88_RS22255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYC88_RS22290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYC88_RS22295	COG2835	tetraacyldisaccharide 4'-kinase activity
HYC88_RS22315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HYC88_RS22355	COG0714	Associated with various cellular activities
HYC88_RS22375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYC88_RS22380	COG0745	RESPONSE REGULATOR receiver
HYC88_RS22385	COG5002	protein histidine kinase activity
HYC88_RS22385	COG5000	phosphorelay sensor kinase activity
HYC88_RS22390	COG0823	Involved in the tonB-independent uptake of proteins
HYC88_RS22400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYC88_RS22405	COG2197	response regulator
HYC88_RS22420	COG0653	protein targeting
HYC88_RS22445	COG2902	Dehydrogenase
HYC88_RS22450	COG1134	teichoic acid transport
HYC88_RS22460	COG1309	transcriptional regulator
HYC88_RS22470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYC88_RS22475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYC88_RS22480	COG2226	methyltransferase
HYC88_RS22480	COG1073	alpha beta
HYC88_RS22485	COG4122	O-methyltransferase activity
HYC88_RS22490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYC88_RS22495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYC88_RS22500	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS22510	COG0395	ABC-type sugar transport system, permease component
HYC88_RS22515	COG1175	transmembrane transport
HYC88_RS22520	COG1653	transport
HYC88_RS22530	COG0515	serine threonine protein kinase
HYC88_RS22535	COG0515	serine threonine protein kinase
HYC88_RS22540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYC88_RS22555	COG2884	Cell division ATP-binding protein ftsE
HYC88_RS22560	COG2177	Part of the ABC transporter FtsEX involved in
HYC88_RS22575	COG0793	Belongs to the peptidase S41A family
HYC88_RS22580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYC88_RS22590	COG1132	(ABC) transporter
HYC88_RS22595	COG1132	(ABC) transporter
HYC88_RS22615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS22620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS22625	COG1120	ATPase activity
HYC88_RS22635	COG0583	DNA-binding transcription factor activity
HYC88_RS22690	COG3973	AAA domain
HYC88_RS22690	COG3973	AAA domain
HYC88_RS22700	COG0776	regulation of translation
HYC88_RS22715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYC88_RS22720	COG1678	Uncharacterized ACR, COG1678
HYC88_RS22740	COG0395	ABC-type sugar transport system, permease component
HYC88_RS22745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYC88_RS22790	COG2814	Major facilitator Superfamily
HYC88_RS22800	COG3654	unkown
HYC88_RS22815	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYC88_RS22820	COG2211	Major facilitator Superfamily
HYC88_RS22835	COG1732	Glycine betaine
HYC88_RS22840	COG1174	glycine betaine transport
HYC88_RS22850	COG1174	glycine betaine transport
HYC88_RS22860	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HYC88_RS22870	COG0277	FAD linked oxidase domain protein
HYC88_RS22905	COG1335	isochorismatase
HYC88_RS22915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HYC88_RS22925	COG1113	amino acid transport
HYC88_RS22935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYC88_RS22940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS22965	COG1234	tRNA 3'-trailer cleavage
HYC88_RS22975	COG1263	PTS System
HYC88_RS22980	COG1263	PTS System
HYC88_RS22985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYC88_RS22990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYC88_RS23000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYC88_RS23020	COG0477	Major facilitator Superfamily
HYC88_RS23045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYC88_RS23060	COG4555	ABC transporter
HYC88_RS23075	COG2733	membrane
HYC88_RS23180	COG3764	Sortase (surface protein transpeptidase)
HYC88_RS23190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYC88_RS23200	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
HYC88_RS23200	COG0706	membrane insertase activity
HYC88_RS23210	COG4702	Belongs to the UPF0303 family
HYC88_RS23215	COG0673	inositol 2-dehydrogenase activity
HYC88_RS23230	COG2188	Transcriptional regulator
HYC88_RS23235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYC88_RS23315	COG3397	chitin binding
HYC88_RS23320	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS23335	COG1126	abc transporter atp-binding protein
HYC88_RS23340	COG0765	amino acid transport
HYC88_RS23345	COG0765	amino acid transport
HYC88_RS23350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS23365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS23415	COG0588	phosphoglycerate mutase activity
HYC88_RS23455	COG2985	domain, Protein
HYC88_RS23460	COG2985	domain, Protein
HYC88_RS23475	COG0395	ABC-type sugar transport system, permease component
HYC88_RS23505	COG4977	sequence-specific DNA binding
HYC88_RS23515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYC88_RS23540	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HYC88_RS23575	COG1733	regulation of RNA biosynthetic process
HYC88_RS23590	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS23605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYC88_RS23610	COG1309	transcriptional regulator
HYC88_RS23630	COG2755	lipolytic protein G-D-S-L family
HYC88_RS23630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HYC88_RS23655	COG1946	Acyl-CoA thioesterase
HYC88_RS23710	COG0515	serine threonine protein kinase
HYC88_RS23710	COG2815	serine threonine protein kinase
HYC88_RS23720	COG0657	acetylesterase activity
HYC88_RS23745	COG4106	trans-aconitate 2-methyltransferase activity
HYC88_RS23790	COG1674	ftsk spoiiie
HYC88_RS23825	COG0028	Belongs to the TPP enzyme family
HYC88_RS23855	COG1472	Belongs to the glycosyl hydrolase 3 family
HYC88_RS23870	COG1404	Belongs to the peptidase S8 family
HYC88_RS23875	COG1672	PFAM Archaeal ATPase
HYC88_RS23875	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYC88_RS23905	COG0515	serine threonine protein kinase
HYC88_RS23940	COG1609	Transcriptional regulator
HYC88_RS23945	COG0673	inositol 2-dehydrogenase activity
HYC88_RS23960	COG2318	DinB family
HYC88_RS23985	COG1136	(ABC) transporter
HYC88_RS24000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYC88_RS24025	COG2409	Drug exporters of the RND superfamily
HYC88_RS24040	COG2318	DinB family
HYC88_RS24060	COG3718	enzyme involved in inositol metabolism
HYC88_RS24065	COG3962	Belongs to the TPP enzyme family
HYC88_RS24095	COG1131	(ABC) transporter
HYC88_RS24130	COG4585	Histidine kinase
HYC88_RS24135	COG2197	response regulator
HYC88_RS24165	COG0629	single-stranded DNA binding
HYC88_RS24195	COG1136	(ABC) transporter
HYC88_RS24195	COG0577	efflux transmembrane transporter activity
HYC88_RS24215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYC88_RS24245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS24260	COG1486	melibiose metabolic process
HYC88_RS24265	COG0395	ABC-type sugar transport system, permease component
HYC88_RS24270	COG1175	transmembrane transport
HYC88_RS24280	COG1940	carbohydrate kinase activity
HYC88_RS24285	COG0668	transmembrane transport
HYC88_RS24295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYC88_RS24295	COG3291	Pkd domain containing protein
HYC88_RS24320	COG4266	Belongs to the allantoicase family
HYC88_RS24335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HYC88_RS24340	COG4988	ABC transporter
HYC88_RS24350	COG1271	oxidase subunit
HYC88_RS24370	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYC88_RS24395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYC88_RS24410	COG2252	PERMEase
HYC88_RS24420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYC88_RS24430	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS24465	COG0110	maltose O-acetyltransferase activity
HYC88_RS24475	COG0640	Transcriptional regulator
HYC88_RS24480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYC88_RS24485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYC88_RS24490	COG0584	glycerophosphoryl diester phosphodiesterase
HYC88_RS24495	COG1113	amino acid transport
HYC88_RS24500	COG1113	amino acid transport
HYC88_RS24505	COG1268	BioY protein
HYC88_RS24515	COG1113	amino acid transport
HYC88_RS24535	COG0475	glutathione-regulated potassium exporter activity
HYC88_RS24545	COG3594	Acyltransferase
HYC88_RS24565	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYC88_RS24570	COG0740	serine-type endopeptidase activity
HYC88_RS24575	COG0740	serine-type endopeptidase activity
HYC88_RS24580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYC88_RS24590	COG0525	valine-tRNA ligase activity
HYC88_RS24595	COG0285	dihydrofolate synthase activity
HYC88_RS24605	COG0105	UTP biosynthetic process
HYC88_RS24610	COG1077	Cell shape determining protein MreB Mrl
HYC88_RS24630	COG0772	Belongs to the SEDS family
HYC88_RS24660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYC88_RS24665	COG0673	inositol 2-dehydrogenase activity
HYC88_RS24685	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS24700	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS24725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYC88_RS24730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYC88_RS24735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYC88_RS24755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYC88_RS24760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYC88_RS24770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HYC88_RS24785	COG0501	Belongs to the peptidase M48B family
HYC88_RS24800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYC88_RS24810	COG0799	negative regulation of ribosome biogenesis
HYC88_RS24815	COG0588	phosphoglycerate mutase activity
HYC88_RS24835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HYC88_RS24845	COG0495	leucyl-tRNA aminoacylation
HYC88_RS24855	COG1307	EDD domain protein, DegV family
HYC88_RS24860	COG1555	photosystem II stabilization
HYC88_RS24895	COG0268	Binds directly to 16S ribosomal RNA
HYC88_RS24900	COG0481	GTPase activity
HYC88_RS24905	COG1022	Amp-dependent synthetase and ligase
HYC88_RS24945	COG1420	regulation of RNA biosynthetic process
HYC88_RS24950	COG0484	heat shock protein binding
HYC88_RS24965	COG0537	adenosine 5'-monophosphoramidase activity
HYC88_RS24970	COG1234	tRNA 3'-trailer cleavage
HYC88_RS24975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYC88_RS24985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYC88_RS24995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYC88_RS25005	COG2315	Protein conserved in bacteria
HYC88_RS25025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYC88_RS25040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYC88_RS25050	COG1381	Involved in DNA repair and RecF pathway recombination
HYC88_RS25055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYC88_RS25065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYC88_RS25080	COG0423	glycine-tRNA ligase activity
HYC88_RS25145	COG0454	-acetyltransferase
HYC88_RS25155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYC88_RS25180	COG1595	DNA-templated transcription, initiation
HYC88_RS25200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYC88_RS25210	COG1136	(ABC) transporter
HYC88_RS25230	COG2066	Belongs to the glutaminase family
HYC88_RS25250	COG1309	transcriptional regulator
HYC88_RS25260	COG2235	arginine
HYC88_RS25290	COG2188	Transcriptional regulator
HYC88_RS25310	COG3842	ATPase activity
HYC88_RS25320	COG0574	Belongs to the PEP-utilizing enzyme family
HYC88_RS25320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYC88_RS25345	COG2146	nitrite reductase [NAD(P)H] activity
HYC88_RS25345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYC88_RS25390	COG2949	membrane
HYC88_RS25400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYC88_RS25410	COG0358	DNA primase activity
HYC88_RS25415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYC88_RS25430	COG1070	Carbohydrate kinase
HYC88_RS25465	COG2175	clavaminate synthase activity
HYC88_RS25470	COG3246	L-lysine catabolic process to acetate
HYC88_RS25495	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS25505	COG1404	Belongs to the peptidase S8 family
HYC88_RS25510	COG1404	Belongs to the peptidase S8 family
HYC88_RS25525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYC88_RS25530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYC88_RS25540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS25575	COG2233	PERMEase
HYC88_RS25580	COG0402	S-adenosylhomocysteine deaminase activity
HYC88_RS25590	COG1609	Transcriptional regulator
HYC88_RS25620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYC88_RS25650	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS25670	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS25675	COG1309	transcriptional regulator
HYC88_RS25705	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS25710	COG3291	Pkd domain containing protein
HYC88_RS25725	COG1522	sequence-specific DNA binding
HYC88_RS25750	COG2130	NADP-dependent
HYC88_RS25755	COG1764	response to oxidative stress
HYC88_RS25765	COG1280	lysine exporter protein (LysE YggA)
HYC88_RS25785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYC88_RS25790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYC88_RS25795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYC88_RS25810	COG1741	Belongs to the pirin family
HYC88_RS25835	COG2814	Major facilitator Superfamily
HYC88_RS25875	COG1929	Belongs to the glycerate kinase type-1 family
HYC88_RS25885	COG0745	RESPONSE REGULATOR receiver
HYC88_RS25890	COG2205	protein histidine kinase activity
HYC88_RS25900	COG0789	Transcriptional regulator
HYC88_RS25905	COG0667	Aldo Keto reductase
HYC88_RS25920	COG2197	response regulator
HYC88_RS25925	COG4585	Histidine kinase
HYC88_RS25945	COG0477	Major facilitator Superfamily
HYC88_RS25955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HYC88_RS26000	COG1358	cellular component organization or biogenesis
HYC88_RS26045	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HYC88_RS26075	COG0483	inositol monophosphate 1-phosphatase activity
HYC88_RS26130	COG0390	transport system, permease component
HYC88_RS26165	COG2124	cytochrome p450
HYC88_RS26170	COG0183	Belongs to the thiolase family
HYC88_RS26265	COG1309	transcriptional regulator
HYC88_RS26270	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS26320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS26340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYC88_RS26345	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYC88_RS26360	COG3340	Belongs to the peptidase S51 family
HYC88_RS26370	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS26375	COG0183	Belongs to the thiolase family
HYC88_RS26380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYC88_RS26390	COG2030	dehydratase
HYC88_RS26400	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS26410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYC88_RS26415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYC88_RS26435	COG0800	Aldolase
HYC88_RS26440	COG3022	response to hydroperoxide
HYC88_RS26495	COG0384	phenazine biosynthesis protein PhzF
HYC88_RS26505	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS26510	COG3540	Alkaline phosphatase
HYC88_RS26520	COG2814	Major facilitator Superfamily
HYC88_RS26535	COG1834	amidinotransferase
HYC88_RS26555	COG1120	ATPase activity
HYC88_RS26560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS26565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYC88_RS26580	COG0384	phenazine biosynthesis protein PhzF
HYC88_RS26620	COG1994	Peptidase M50
HYC88_RS26640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYC88_RS26645	COG0477	Major facilitator Superfamily
HYC88_RS26660	COG2814	Major facilitator Superfamily
HYC88_RS26665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYC88_RS26665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYC88_RS26670	COG2132	Multicopper oxidase
HYC88_RS26695	COG0174	glutamine synthetase
HYC88_RS26740	COG2814	Major facilitator Superfamily
HYC88_RS26745	COG2890	protein-(glutamine-N5) methyltransferase activity
HYC88_RS26750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HYC88_RS26760	COG1609	Transcriptional regulator
HYC88_RS26765	COG2182	Extracellular solute-binding protein
HYC88_RS26775	COG0395	ABC-type sugar transport system, permease component
HYC88_RS26780	COG0366	Alpha amylase catalytic
HYC88_RS26840	COG2197	response regulator
HYC88_RS26850	COG2409	Drug exporters of the RND superfamily
HYC88_RS26855	COG0745	RESPONSE REGULATOR receiver
HYC88_RS26880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYC88_RS26885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYC88_RS26915	COG2362	D-Aminopeptidase
HYC88_RS26920	COG3467	pyridoxamine 5'-phosphate
HYC88_RS26925	COG3896	Chloramphenicol phosphotransferase-like protein
HYC88_RS26930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYC88_RS26935	COG1715	Restriction endonuclease
HYC88_RS26940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYC88_RS27005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYC88_RS27010	COG0321	lipoyl(octanoyl) transferase activity
HYC88_RS27025	COG1090	epimerase
HYC88_RS27045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HYC88_RS27055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYC88_RS27060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYC88_RS27065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYC88_RS27070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYC88_RS27085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HYC88_RS27100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYC88_RS27125	COG4585	Histidine kinase
HYC88_RS27130	COG2197	response regulator
HYC88_RS27135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYC88_RS27145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYC88_RS27165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYC88_RS27175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYC88_RS27180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYC88_RS27190	COG1376	ErfK ybiS ycfS ynhG family protein
HYC88_RS27200	COG1845	cytochrome c oxidase, subunit III
HYC88_RS27205	COG2010	Cytochrome c
HYC88_RS27210	COG0723	plastoquinol--plastocyanin reductase activity
HYC88_RS27215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYC88_RS27220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYC88_RS27225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYC88_RS27270	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS27290	COG0003	Pfam Anion-transporting ATPase
HYC88_RS27300	COG1940	carbohydrate kinase activity
HYC88_RS27330	COG2197	response regulator
HYC88_RS27335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYC88_RS27350	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HYC88_RS27360	COG2193	ferroxidase activity
HYC88_RS27365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HYC88_RS27370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HYC88_RS27375	COG2815	serine threonine protein kinase
HYC88_RS27375	COG0515	serine threonine protein kinase
HYC88_RS27380	COG2022	thiamine diphosphate biosynthetic process
HYC88_RS27390	COG2022	thiamine diphosphate biosynthetic process
HYC88_RS27390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYC88_RS27410	COG0352	thiamine-phosphate diphosphorylase activity
HYC88_RS27445	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HYC88_RS27455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYC88_RS27475	COG0714	Associated with various cellular activities
HYC88_RS27485	COG0275	rRNA processing
HYC88_RS27495	COG0768	penicillin binding
HYC88_RS27500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYC88_RS27510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYC88_RS27515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYC88_RS27525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYC88_RS27545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYC88_RS27550	COG1799	cell septum assembly
HYC88_RS27560	COG3599	regulation of cell shape
HYC88_RS27565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYC88_RS27575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYC88_RS27620	COG0587	DNA-directed DNA polymerase activity
HYC88_RS27630	COG1432	Conserved Protein
HYC88_RS27670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYC88_RS27675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYC88_RS27680	COG0131	Imidazoleglycerol-phosphate dehydratase
HYC88_RS27690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HYC88_RS27695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HYC88_RS27700	COG0251	oxidation-reduction process
HYC88_RS27705	COG0107	imidazoleglycerol-phosphate synthase activity
HYC88_RS27740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HYC88_RS27745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYC88_RS27765	COG0134	indole-3-glycerol-phosphate synthase activity
HYC88_RS27775	COG0133	tryptophan synthase activity
HYC88_RS27780	COG0159	tryptophan synthase activity
HYC88_RS27790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYC88_RS27800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYC88_RS27805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYC88_RS27835	COG0069	glutamate synthase activity
HYC88_RS27835	COG0070	glutamate synthase
HYC88_RS27835	COG0067	glutamate synthase
HYC88_RS27845	COG0705	Rhomboid family
HYC88_RS27865	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS27870	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS27875	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS27880	COG1309	transcriptional regulator
HYC88_RS27890	COG1278	Cold shock
HYC88_RS27915	COG1024	Enoyl-CoA hydratase
HYC88_RS27920	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS27960	COG0287	Prephenate dehydrogenase
HYC88_RS27960	COG1605	Chorismate mutase
HYC88_RS27990	COG0737	Belongs to the 5'-nucleotidase family
HYC88_RS28045	COG2050	protein possibly involved in aromatic compounds catabolism
HYC88_RS28080	COG1643	Atp-dependent helicase
HYC88_RS28085	COG2226	methyltransferase
HYC88_RS28105	COG0237	dephospho-CoA kinase activity
HYC88_RS28120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYC88_RS28130	COG0330	HflC and HflK could
HYC88_RS28135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYC88_RS28160	COG0436	Aminotransferase
HYC88_RS28180	COG2313	pseudouridylate synthase activity
HYC88_RS28190	COG2814	Major facilitator Superfamily
HYC88_RS28195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYC88_RS28200	COG0584	glycerophosphoryl diester phosphodiesterase
HYC88_RS28210	COG0556	nucleotide-excision repair
HYC88_RS28240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYC88_RS28265	COG0322	excinuclease ABC activity
HYC88_RS28270	COG1660	Displays ATPase and GTPase activities
HYC88_RS28275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYC88_RS28280	COG1481	regulation of sporulation
HYC88_RS28285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYC88_RS28290	COG0126	phosphoglycerate kinase activity
HYC88_RS28295	COG0149	triose-phosphate isomerase activity
HYC88_RS28300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYC88_RS28310	COG0166	Belongs to the GPI family
HYC88_RS28325	COG4195	phage-related replication protein
HYC88_RS28345	COG0363	glucosamine-6-phosphate deaminase activity
HYC88_RS28360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYC88_RS28370	COG0109	protoheme IX farnesyltransferase activity
HYC88_RS28410	COG0719	Fe-S assembly protein
HYC88_RS28420	COG0396	ATPase activity
HYC88_RS28425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYC88_RS28430	COG0822	iron-sulfur transferase activity
HYC88_RS28435	COG2151	metal-sulfur cluster biosynthetic enzyme
HYC88_RS28450	COG3226	Transcriptional regulator
HYC88_RS28465	COG2171	N-acyltransferase activity
HYC88_RS28470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYC88_RS28510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYC88_RS28515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYC88_RS28530	COG0768	penicillin binding
HYC88_RS28535	COG2197	response regulator
HYC88_RS28540	COG4585	Histidine kinase
HYC88_RS28555	COG1414	Transcriptional regulator
HYC88_RS28580	COG1902	pentaerythritol trinitrate reductase activity
HYC88_RS28605	COG0494	nUDIX hydrolase
HYC88_RS28615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYC88_RS28620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYC88_RS28625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYC88_RS28630	COG2318	DinB family
HYC88_RS28640	COG0367	asparagine synthase
HYC88_RS28660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYC88_RS28670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYC88_RS28690	COG1086	Polysaccharide biosynthesis protein
HYC88_RS28700	COG1132	(ABC) transporter
HYC88_RS28705	COG1132	(ABC) transporter
HYC88_RS28715	COG1917	Cupin 2, conserved barrel domain protein
HYC88_RS28730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYC88_RS28755	COG1797	cobyrinic acid a,c-diamide synthase activity
HYC88_RS28770	COG1492	cobalamin metabolic process
HYC88_RS28775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HYC88_RS28790	COG0235	Class ii aldolase
HYC88_RS28810	COG0488	(ABC) transporter
HYC88_RS28820	COG1024	Enoyl-CoA hydratase
HYC88_RS28860	COG3387	PFAM Glycoside hydrolase 15-related
HYC88_RS28895	COG1063	alcohol dehydrogenase
HYC88_RS28910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYC88_RS28915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYC88_RS28935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYC88_RS28950	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS28955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYC88_RS28965	COG2186	Transcriptional regulator
HYC88_RS28985	COG3830	Belongs to the UPF0237 family
HYC88_RS28985	COG0560	Phosphoserine phosphatase
HYC88_RS28990	COG0842	Transport permease protein
HYC88_RS28990	COG1131	(ABC) transporter
HYC88_RS28990	COG1716	ATPase activity
HYC88_RS29000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYC88_RS29010	COG4585	Histidine kinase
HYC88_RS29015	COG2197	response regulator
HYC88_RS29030	COG1119	ATPase activity
HYC88_RS29055	COG1881	PFAM PEBP family protein
HYC88_RS29065	COG2094	Belongs to the DNA glycosylase MPG family
HYC88_RS29095	COG0647	UMP catabolic process
HYC88_RS29100	COG1120	ATPase activity
HYC88_RS29120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYC88_RS29125	COG0497	DNA recombination
HYC88_RS29150	COG3387	PFAM Glycoside hydrolase 15-related
HYC88_RS29155	COG0504	CTP synthase activity
HYC88_RS29160	COG0494	nUDIX hydrolase
HYC88_RS29170	COG0686	Belongs to the AlaDH PNT family
HYC88_RS29185	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYC88_RS29190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYC88_RS29210	COG0494	nUDIX hydrolase
HYC88_RS29250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYC88_RS29260	COG1160	GTP binding
HYC88_RS29275	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS29295	COG0671	phosphoesterase, PA-phosphatase related
HYC88_RS29300	COG0477	Major facilitator Superfamily
HYC88_RS29305	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS29310	COG1799	cell septum assembly
HYC88_RS29320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS29325	COG0765	amino acid transport
HYC88_RS29345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS29350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS29355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS29390	COG0641	radical SAM
HYC88_RS29430	COG0477	Major facilitator Superfamily
HYC88_RS29445	COG0326	Molecular chaperone. Has ATPase activity
HYC88_RS29455	COG2201	protein-glutamate methylesterase activity
HYC88_RS29475	COG0346	lactoylglutathione lyase activity
HYC88_RS29490	COG1725	Transcriptional regulator
HYC88_RS29500	COG2755	lipolytic protein G-D-S-L family
HYC88_RS29510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYC88_RS29520	COG2188	Transcriptional regulator
HYC88_RS29525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HYC88_RS29530	COG1309	transcriptional regulator
HYC88_RS29535	COG0243	molybdopterin cofactor binding
HYC88_RS29540	COG2851	Citrate transporter
HYC88_RS29550	COG2318	DinB family
HYC88_RS29565	COG2326	polyphosphate kinase activity
HYC88_RS29570	COG0697	spore germination
HYC88_RS29580	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS29600	COG0789	Transcriptional regulator
HYC88_RS29615	COG3876	Protein conserved in bacteria
HYC88_RS29625	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS29635	COG2234	aminopeptidase activity
HYC88_RS29635	COG4935	Belongs to the peptidase S8 family
HYC88_RS29640	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS29650	COG2197	response regulator
HYC88_RS29665	COG4585	Histidine kinase
HYC88_RS29670	COG4948	Mandelate Racemase Muconate Lactonizing
HYC88_RS29685	COG2149	membrane
HYC88_RS29690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYC88_RS29695	COG3573	Dehydrogenase
HYC88_RS29710	COG1113	amino acid transport
HYC88_RS29720	COG3265	gluconokinase activity
HYC88_RS29725	COG2186	Transcriptional regulator
HYC88_RS29735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYC88_RS29740	COG0564	pseudouridine synthase activity
HYC88_RS29750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYC88_RS29780	COG0667	Aldo Keto reductase
HYC88_RS29785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS29795	COG0598	Magnesium transport protein CorA
HYC88_RS29815	COG0215	cysteine-tRNA ligase activity
HYC88_RS29825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS29830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYC88_RS29835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYC88_RS29840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYC88_RS29845	COG1414	Transcriptional regulator
HYC88_RS29850	COG0646	methionine synthase
HYC88_RS29850	COG1410	methionine synthase
HYC88_RS29860	COG4166	transmembrane transport
HYC88_RS29865	COG2197	response regulator
HYC88_RS29875	COG1994	Peptidase M50
HYC88_RS29875	COG0517	IMP dehydrogenase activity
HYC88_RS29895	COG1222	aaa ATPase
HYC88_RS29900	COG4122	O-methyltransferase activity
HYC88_RS29910	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HYC88_RS29915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HYC88_RS29920	COG1609	Transcriptional regulator
HYC88_RS29930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HYC88_RS29935	COG0545	Peptidyl-prolyl cis-trans isomerase
HYC88_RS29945	COG2378	regulation of single-species biofilm formation
HYC88_RS29965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYC88_RS29970	COG0805	protein transport
HYC88_RS30010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYC88_RS30015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYC88_RS30060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYC88_RS30065	COG0517	IMP dehydrogenase activity
HYC88_RS30065	COG4175	Glycine betaine
HYC88_RS30110	COG1404	Belongs to the peptidase S8 family
HYC88_RS30130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYC88_RS30140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HYC88_RS30145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYC88_RS30150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYC88_RS30155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYC88_RS30160	COG5002	protein histidine kinase activity
HYC88_RS30165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYC88_RS30170	COG0072	phenylalanine-tRNA ligase activity
HYC88_RS30170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYC88_RS30225	COG0798	PFAM Bile acid sodium symporter
HYC88_RS30235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYC88_RS30245	COG1649	PFAM Uncharacterised BCR, COG1649
HYC88_RS30330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYC88_RS30335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYC88_RS30345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYC88_RS30350	COG1438	arginine binding
HYC88_RS30355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYC88_RS30355	COG0515	serine threonine protein kinase
HYC88_RS30365	COG0137	argininosuccinate synthase activity
HYC88_RS30370	COG0165	Argininosuccinate lyase
HYC88_RS30380	COG3973	AAA domain
HYC88_RS30390	COG0477	Major facilitator Superfamily
HYC88_RS30430	COG2011	ABC-type metal ion transport system permease component
HYC88_RS30435	COG1464	Belongs to the NlpA lipoprotein family
HYC88_RS30450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HYC88_RS30455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYC88_RS30455	COG1648	precorrin-2 dehydrogenase activity
HYC88_RS30510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYC88_RS30520	COG0456	acetyltransferase
HYC88_RS30570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYC88_RS30585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYC88_RS30610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYC88_RS30615	COG1560	Kdo2-lipid A biosynthetic process
HYC88_RS30620	COG0438	transferase activity, transferring glycosyl groups
HYC88_RS30630	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HYC88_RS30635	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HYC88_RS30640	COG0217	transcriptional regulatory protein
HYC88_RS30645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYC88_RS30650	COG0632	four-way junction helicase activity
HYC88_RS30655	COG2255	four-way junction helicase activity
HYC88_RS30665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYC88_RS30670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYC88_RS30675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYC88_RS30685	COG1196	nuclear chromosome segregation
HYC88_RS30700	COG0124	histidyl-tRNA synthetase
HYC88_RS30720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYC88_RS30740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYC88_RS30745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYC88_RS30755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYC88_RS30760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYC88_RS30765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYC88_RS30770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYC88_RS30780	COG0006	proline dipeptidase activity
HYC88_RS30785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYC88_RS30790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYC88_RS30800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYC88_RS30805	COG0540	Belongs to the ATCase OTCase family
HYC88_RS30810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYC88_RS30820	COG0505	Belongs to the CarA family
HYC88_RS30825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYC88_RS30830	COG0167	dihydroorotate dehydrogenase activity
HYC88_RS30835	COG0284	orotidine-5'-phosphate decarboxylase activity
HYC88_RS30850	COG1758	RNA polymerase activity
HYC88_RS30860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYC88_RS30875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYC88_RS30885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYC88_RS30890	COG2390	Transcriptional regulator
HYC88_RS30905	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS30915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYC88_RS30930	COG2233	PERMEase
HYC88_RS30935	COG0738	Major facilitator superfamily
HYC88_RS30945	COG1309	transcriptional regulator
HYC88_RS30960	COG0640	Transcriptional regulator
HYC88_RS30980	COG3201	nicotinamide mononucleotide transporter
HYC88_RS30985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYC88_RS30985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYC88_RS30990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYC88_RS30995	COG0140	phosphoribosyl-ATP diphosphatase activity
HYC88_RS31000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYC88_RS31045	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS31065	COG1216	Glycosyl transferase, family 2
HYC88_RS31080	COG2270	Major facilitator Superfamily
HYC88_RS31090	COG2364	Membrane
HYC88_RS31095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYC88_RS31160	COG2018	Roadblock/LC7 domain
HYC88_RS31190	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HYC88_RS31205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYC88_RS31215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYC88_RS31245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYC88_RS31265	COG1716	ATPase activity
HYC88_RS31285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYC88_RS31295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYC88_RS31295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYC88_RS31330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYC88_RS31365	COG1695	Transcriptional regulator
HYC88_RS31405	COG0697	spore germination
HYC88_RS31460	COG1309	transcriptional regulator
HYC88_RS31470	COG0515	serine threonine protein kinase
HYC88_RS31470	COG2815	serine threonine protein kinase
HYC88_RS31500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYC88_RS31520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYC88_RS31560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYC88_RS31565	COG2226	methyltransferase
HYC88_RS31570	COG0243	molybdopterin cofactor binding
HYC88_RS31580	COG1968	undecaprenyl-diphosphatase activity
HYC88_RS31600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYC88_RS31655	COG1832	CoA-binding protein
HYC88_RS31660	COG1739	Uncharacterized protein family UPF0029
HYC88_RS31670	COG0420	3'-5' exonuclease activity
HYC88_RS31675	COG0419	ATPase involved in DNA repair
HYC88_RS31680	COG1522	sequence-specific DNA binding
HYC88_RS31705	COG0626	cystathionine gamma-synthase activity
HYC88_RS31730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYC88_RS31745	COG1595	DNA-templated transcription, initiation
HYC88_RS31750	COG2188	Transcriptional regulator
HYC88_RS31755	COG1940	carbohydrate kinase activity
HYC88_RS31760	COG2197	response regulator
HYC88_RS31765	COG4585	Histidine kinase
HYC88_RS31770	COG1131	(ABC) transporter
HYC88_RS31785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYC88_RS31805	COG0456	acetyltransferase
HYC88_RS31820	COG2226	methyltransferase
HYC88_RS31825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HYC88_RS31830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYC88_RS31835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYC88_RS31860	COG0583	DNA-binding transcription factor activity
HYC88_RS31865	COG1280	lysine exporter protein (LysE YggA)
HYC88_RS31880	COG0740	serine-type endopeptidase activity
HYC88_RS31895	COG1309	transcriptional regulator
HYC88_RS31900	COG0831	urea catabolic process
HYC88_RS31905	COG0832	Belongs to the urease beta subunit family
HYC88_RS31910	COG0804	urea catabolic process
HYC88_RS31920	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYC88_RS31925	COG0829	nickel cation binding
HYC88_RS31940	COG0204	Acyl-transferase
HYC88_RS31955	COG0205	6-phosphofructokinase activity
HYC88_RS31960	COG3442	glutamine amidotransferase
HYC88_RS31970	COG0242	peptide deformylase activity
HYC88_RS31980	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS31985	COG0386	Belongs to the glutathione peroxidase family
HYC88_RS32020	COG1946	Acyl-CoA thioesterase
HYC88_RS32035	COG1793	dna ligase
HYC88_RS32050	COG1132	(ABC) transporter
HYC88_RS32060	COG0673	inositol 2-dehydrogenase activity
HYC88_RS32065	COG0277	FAD linked oxidase domain protein
HYC88_RS32075	COG1132	(ABC) transporter
HYC88_RS32085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYC88_RS32090	COG2072	flavoprotein involved in K transport
HYC88_RS32095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYC88_RS32105	COG1116	anion transmembrane transporter activity
HYC88_RS32110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYC88_RS32175	COG0484	heat shock protein binding
HYC88_RS32260	COG2957	Belongs to the agmatine deiminase family
HYC88_RS32300	COG0464	growth
HYC88_RS32305	COG1404	Belongs to the peptidase S8 family
HYC88_RS32310	COG1674	ftsk spoiiie
HYC88_RS32330	COG4842	Belongs to the WXG100 family
HYC88_RS32370	COG1309	transcriptional regulator
HYC88_RS32385	COG1024	Enoyl-CoA hydratase
HYC88_RS32385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYC88_RS32400	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HYC88_RS32410	COG1408	metallophosphoesterase
HYC88_RS32415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYC88_RS32420	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYC88_RS32435	COG1891	lyase activity
HYC88_RS32455	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS32460	COG4948	Mandelate Racemase Muconate Lactonizing
HYC88_RS32465	COG2186	Transcriptional regulator
HYC88_RS32485	COG0395	ABC-type sugar transport system, permease component
HYC88_RS32490	COG1175	transmembrane transport
HYC88_RS32495	COG1653	transport
HYC88_RS32500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYC88_RS32505	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYC88_RS32545	COG2815	serine threonine protein kinase
HYC88_RS32545	COG0515	serine threonine protein kinase
HYC88_RS32560	COG3903	Transcriptional regulator
HYC88_RS32560	COG3629	intracellular signal transduction
HYC88_RS32585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS32590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS32620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYC88_RS32660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYC88_RS32670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYC88_RS32680	COG0444	Belongs to the ABC transporter superfamily
HYC88_RS32690	COG0747	negative chemotaxis
HYC88_RS32700	COG3458	cephalosporin-C deacetylase activity
HYC88_RS32710	COG2186	Transcriptional regulator
HYC88_RS32715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYC88_RS32720	COG1940	carbohydrate kinase activity
HYC88_RS32725	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HYC88_RS32760	COG1122	ATPase activity
HYC88_RS32780	COG2080	2 iron, 2 sulfur cluster binding
HYC88_RS32785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYC88_RS32790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYC88_RS32830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYC88_RS32840	COG0542	response to heat
HYC88_RS32860	COG0515	serine threonine protein kinase
HYC88_RS32860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYC88_RS32865	COG0402	S-adenosylhomocysteine deaminase activity
HYC88_RS32870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYC88_RS32875	COG1802	Transcriptional regulator
HYC88_RS32885	COG2835	tetraacyldisaccharide 4'-kinase activity
HYC88_RS32905	COG4981	capsule polysaccharide biosynthetic process
HYC88_RS32910	COG0500	methyltransferase
HYC88_RS32940	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS32945	COG0174	glutamine synthetase
HYC88_RS32955	COG0531	amino acid
HYC88_RS32960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HYC88_RS32995	COG1253	flavin adenine dinucleotide binding
HYC88_RS33030	COG2815	serine threonine protein kinase
HYC88_RS33030	COG0515	serine threonine protein kinase
HYC88_RS33035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYC88_RS33080	COG0187	DNA topoisomerase II activity
HYC88_RS33090	COG2226	methyltransferase
HYC88_RS33110	COG0477	Major facilitator Superfamily
HYC88_RS33125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYC88_RS33150	COG2706	6-phosphogluconolactonase activity
HYC88_RS33165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYC88_RS33215	COG0671	phosphoesterase, PA-phosphatase related
HYC88_RS33235	COG0584	glycerophosphoryl diester phosphodiesterase
HYC88_RS33280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYC88_RS33295	COG1940	carbohydrate kinase activity
HYC88_RS33300	COG0494	nUDIX hydrolase
HYC88_RS33315	COG0445	tRNA wobble uridine modification
HYC88_RS33330	COG4585	Histidine kinase
HYC88_RS33335	COG2197	response regulator
HYC88_RS33350	COG2223	nitrite transmembrane transporter activity
HYC88_RS33355	COG1940	carbohydrate kinase activity
HYC88_RS33385	COG0702	epimerase
HYC88_RS33400	COG1349	DNA-binding transcription factor activity
HYC88_RS33410	COG0464	growth
HYC88_RS33430	COG0477	Major facilitator Superfamily
HYC88_RS33455	COG5000	phosphorelay sensor kinase activity
HYC88_RS33455	COG5002	protein histidine kinase activity
HYC88_RS33485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYC88_RS33540	COG1132	(ABC) transporter
HYC88_RS33545	COG0328	RNA-DNA hybrid ribonuclease activity
HYC88_RS33595	COG0842	Transport permease protein
HYC88_RS33595	COG1131	(ABC) transporter
HYC88_RS33595	COG1716	ATPase activity
HYC88_RS33625	COG1879	ABC-type sugar transport system periplasmic component
HYC88_RS33630	COG1129	ABC transporter
HYC88_RS33640	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYC88_RS33645	COG1609	Transcriptional regulator
HYC88_RS33660	COG0366	Alpha amylase catalytic
HYC88_RS33660	COG1874	Beta-galactosidase
HYC88_RS33670	COG1309	transcriptional regulator
HYC88_RS33695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS33700	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS33705	COG1120	ATPase activity
HYC88_RS33740	COG1959	2 iron, 2 sulfur cluster binding
HYC88_RS33740	COG1295	ribonuclease BN
HYC88_RS33790	COG4166	transmembrane transport
HYC88_RS33795	COG0601	transmembrane transport
HYC88_RS33800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYC88_RS33805	COG0444	Belongs to the ABC transporter superfamily
HYC88_RS33810	COG4608	Belongs to the ABC transporter superfamily
HYC88_RS33860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS33865	COG1120	ATPase activity
HYC88_RS33880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HYC88_RS33885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYC88_RS33895	COG0824	Thioesterase
HYC88_RS33895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYC88_RS33900	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYC88_RS33905	COG3246	L-lysine catabolic process to acetate
HYC88_RS33910	COG1309	transcriptional regulator
HYC88_RS33915	COG1191	sigma factor activity
HYC88_RS33945	COG0488	(ABC) transporter
HYC88_RS33960	COG1461	Dihydroxyacetone kinase
HYC88_RS33965	COG2376	Dihydroxyacetone kinase
HYC88_RS33980	COG0494	nUDIX hydrolase
HYC88_RS33985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYC88_RS34015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYC88_RS34020	COG0494	nUDIX hydrolase
HYC88_RS34035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYC88_RS34035	COG0515	serine threonine protein kinase
HYC88_RS34075	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HYC88_RS34085	COG4166	transmembrane transport
HYC88_RS34105	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYC88_RS34110	COG1793	dna ligase
HYC88_RS34110	COG3285	dna ligase
HYC88_RS34125	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS34135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYC88_RS34140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS34165	COG0587	DNA-directed DNA polymerase activity
HYC88_RS34185	COG1131	(ABC) transporter
HYC88_RS34190	COG3559	Exporter of polyketide antibiotics
HYC88_RS34220	COG0745	RESPONSE REGULATOR receiver
HYC88_RS34225	COG5002	protein histidine kinase activity
HYC88_RS34250	COG0494	nUDIX hydrolase
HYC88_RS34265	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HYC88_RS34270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS34275	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS34280	COG1120	ATPase activity
HYC88_RS34285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYC88_RS34300	COG1132	(ABC) transporter
HYC88_RS34305	COG2382	esterase
HYC88_RS34365	COG0148	phosphopyruvate hydratase activity
HYC88_RS34410	COG3845	ABC transporter
HYC88_RS34445	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYC88_RS34450	COG1535	isochorismatase
HYC88_RS34450	COG3433	isochorismatase activity
HYC88_RS34455	COG1535	isochorismatase
HYC88_RS34455	COG3433	isochorismatase activity
HYC88_RS34460	COG1021	2,3-dihydroxybenzoate-AMP ligase
HYC88_RS34465	COG1169	isochorismate synthase
HYC88_RS34470	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS34475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYC88_RS34480	COG2382	esterase
HYC88_RS34485	COG0477	Major facilitator Superfamily
HYC88_RS34495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYC88_RS34505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYC88_RS34510	COG1120	ATPase activity
HYC88_RS34550	COG2365	Tyrosine phosphatase family
HYC88_RS34595	COG2080	2 iron, 2 sulfur cluster binding
HYC88_RS34600	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYC88_RS34605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYC88_RS34615	COG1012	belongs to the aldehyde dehydrogenase family
HYC88_RS34620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYC88_RS34640	COG2066	Belongs to the glutaminase family
HYC88_RS34640	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HYC88_RS34645	COG2356	endonuclease I
HYC88_RS34660	COG2813	Specifically methylates the guanine in position
HYC88_RS34665	COG1960	acyl-CoA dehydrogenase activity
HYC88_RS34720	COG0659	secondary active sulfate transmembrane transporter activity
HYC88_RS34745	COG0515	serine threonine protein kinase
HYC88_RS34755	COG3458	cephalosporin-C deacetylase activity
HYC88_RS34790	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS34795	COG0395	ABC-type sugar transport system, permease component
HYC88_RS34800	COG1175	transmembrane transport
HYC88_RS34810	COG1609	Transcriptional regulator
HYC88_RS34815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYC88_RS34820	COG2070	2-Nitropropane dioxygenase
HYC88_RS34835	COG2366	antibiotic biosynthetic process
HYC88_RS34840	COG0318	PFAM AMP-dependent synthetase and ligase
HYC88_RS34850	COG1126	abc transporter atp-binding protein
HYC88_RS34855	COG0765	amino acid transport
HYC88_RS34860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYC88_RS34885	COG1024	Enoyl-CoA hydratase
HYC88_RS34945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYC88_RS34950	COG0254	rRNA binding
HYC88_RS34975	COG2318	DinB family
HYC88_RS35005	COG0596	Alpha beta hydrolase
HYC88_RS35025	COG0681	Belongs to the peptidase S26 family
HYC88_RS35035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYC88_RS35050	COG1349	DNA-binding transcription factor activity
HYC88_RS35065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYC88_RS35110	COG1175	transmembrane transport
HYC88_RS35115	COG0395	ABC-type sugar transport system, permease component
HYC88_RS35120	COG0366	Alpha amylase catalytic
HYC88_RS35130	COG2318	DinB family
HYC88_RS35145	COG0642	Histidine kinase
HYC88_RS35175	COG0702	epimerase
HYC88_RS35180	COG2226	methyltransferase
HYC88_RS35190	COG1064	alcohol dehydrogenase
HYC88_RS35205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYC88_RS35210	COG3457	Alanine racemase
HYC88_RS35215	COG0626	cystathionine gamma-synthase activity
HYC88_RS35220	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HYC88_RS35240	COG2188	Transcriptional regulator
HYC88_RS35260	COG0789	Transcriptional regulator
HYC88_RS35270	COG1764	response to oxidative stress
HYC88_RS35275	COG1846	Transcriptional regulator
HYC88_RS35285	COG0477	Major facilitator Superfamily
HYC88_RS35330	COG5297	Belongs to the glycosyl hydrolase family 6
HYC88_RS35350	COG4941	Belongs to the sigma-70 factor family
HYC88_RS35355	COG3795	YCII-related domain
HYC88_RS35405	COG3848	Pyruvate phosphate dikinase
HYC88_RS35405	COG0574	Belongs to the PEP-utilizing enzyme family
HYC88_RS35410	COG1028	Short-chain dehydrogenase reductase Sdr
HYC88_RS35415	COG2072	flavoprotein involved in K transport
HYC88_RS35635	COG0420	3'-5' exonuclease activity
HYC88_RS35640	COG0419	ATPase involved in DNA repair