locus-tag	class	description
HXS80_RS00155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXS80_RS00170	COG0395	ABC-type sugar transport system, permease component
HXS80_RS00225	COG1070	Carbohydrate kinase
HXS80_RS00235	COG0406	alpha-ribazole phosphatase activity
HXS80_RS00240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXS80_RS00250	COG4213	ABC transporter substrate-binding protein
HXS80_RS00260	COG4214	carbohydrate transport
HXS80_RS00270	COG0829	nickel cation binding
HXS80_RS00275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HXS80_RS00280	COG0830	nickel cation binding
HXS80_RS00290	COG0832	Belongs to the urease beta subunit family
HXS80_RS00295	COG0831	urea catabolic process
HXS80_RS00320	COG1404	Belongs to the peptidase S8 family
HXS80_RS00330	COG2205	protein histidine kinase activity
HXS80_RS00335	COG0745	RESPONSE REGULATOR receiver
HXS80_RS00340	COG2226	methyltransferase
HXS80_RS00355	COG0586	Pfam SNARE associated Golgi protein
HXS80_RS00410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HXS80_RS00425	COG1120	ATPase activity
HXS80_RS00430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS00445	COG0745	RESPONSE REGULATOR receiver
HXS80_RS00450	COG2205	protein histidine kinase activity
HXS80_RS00480	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HXS80_RS00485	COG0714	Associated with various cellular activities
HXS80_RS00495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXS80_RS00505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXS80_RS00510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXS80_RS00515	COG0395	ABC-type sugar transport system, permease component
HXS80_RS00530	COG1609	Transcriptional regulator
HXS80_RS00540	COG2318	DinB family
HXS80_RS00570	COG0009	L-threonylcarbamoyladenylate synthase
HXS80_RS00590	COG0488	(ABC) transporter
HXS80_RS00630	COG2340	Cysteine-rich secretory protein family
HXS80_RS00640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HXS80_RS00650	COG1357	PFAM Pentapeptide repeats (8 copies)
HXS80_RS00670	COG1024	Enoyl-CoA hydratase
HXS80_RS00685	COG0456	acetyltransferase
HXS80_RS00695	COG2018	Roadblock/LC7 domain
HXS80_RS00710	COG0640	Transcriptional regulator
HXS80_RS00750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXS80_RS00800	COG0385	Bile acid
HXS80_RS00810	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS00830	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS00835	COG0789	Transcriptional regulator
HXS80_RS00850	COG1349	DNA-binding transcription factor activity
HXS80_RS00870	COG1063	alcohol dehydrogenase
HXS80_RS00890	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HXS80_RS00895	COG1132	(ABC) transporter
HXS80_RS00905	COG0596	Alpha beta hydrolase
HXS80_RS00915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXS80_RS00945	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS00950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS00965	COG0693	protein deglycase activity
HXS80_RS00970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HXS80_RS00985	COG0477	Major facilitator Superfamily
HXS80_RS00990	COG1278	Cold shock
HXS80_RS01015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXS80_RS01075	COG1796	DNA polymerase
HXS80_RS01075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HXS80_RS01175	COG0444	Belongs to the ABC transporter superfamily
HXS80_RS01180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXS80_RS01185	COG0601	transmembrane transport
HXS80_RS01200	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS01205	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS01225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXS80_RS01235	COG0517	IMP dehydrogenase activity
HXS80_RS01235	COG1125	glycine betaine transport
HXS80_RS01240	COG0656	L-ascorbic acid biosynthetic process
HXS80_RS01255	COG1174	glycine betaine transport
HXS80_RS01260	COG1174	glycine betaine transport
HXS80_RS01275	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS01275	COG0297	glycogen (starch) synthase activity
HXS80_RS01280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXS80_RS01290	COG0728	peptidoglycan biosynthetic process
HXS80_RS01295	COG0726	polysaccharide deacetylase
HXS80_RS01300	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS01320	COG2304	oxidoreductase activity
HXS80_RS01345	COG1132	(ABC) transporter
HXS80_RS01350	COG1132	(ABC) transporter
HXS80_RS01375	COG1120	ATPase activity
HXS80_RS01380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS01385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS01400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXS80_RS01405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXS80_RS01410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXS80_RS01415	COG0254	rRNA binding
HXS80_RS01530	COG1228	amidohydrolase
HXS80_RS01540	COG1834	amidinotransferase
HXS80_RS01545	COG2045	Belongs to the ComB family
HXS80_RS01555	COG1191	sigma factor activity
HXS80_RS01575	COG0714	Associated with various cellular activities
HXS80_RS01610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXS80_RS01615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXS80_RS01625	COG1609	Transcriptional regulator
HXS80_RS01645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXS80_RS01650	COG0121	glutamine amidotransferase
HXS80_RS01655	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HXS80_RS01670	COG1653	transport
HXS80_RS01675	COG3360	Dodecin
HXS80_RS01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS01695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HXS80_RS01700	COG1053	succinate dehydrogenase
HXS80_RS01780	COG3275	phosphorelay sensor kinase activity
HXS80_RS01785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXS80_RS01800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HXS80_RS01840	COG1191	sigma factor activity
HXS80_RS01845	COG2201	protein-glutamate methylesterase activity
HXS80_RS01850	COG4251	negative regulation of phosphorylation
HXS80_RS01855	COG0784	Response regulator, receiver
HXS80_RS01865	COG2208	phosphoserine phosphatase activity
HXS80_RS01890	COG1652	LysM domain
HXS80_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS01940	COG0596	Alpha beta hydrolase
HXS80_RS01940	COG0596	Alpha beta hydrolase
HXS80_RS01970	COG1595	DNA-templated transcription, initiation
HXS80_RS01980	COG1119	ATPase activity
HXS80_RS01995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HXS80_RS02000	COG2837	iron assimilation
HXS80_RS02005	COG0019	diaminopimelate decarboxylase activity
HXS80_RS02015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HXS80_RS02045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HXS80_RS02150	COG2226	methyltransferase
HXS80_RS02165	COG2130	NADP-dependent
HXS80_RS02215	COG1846	Transcriptional regulator
HXS80_RS02220	COG2409	Drug exporters of the RND superfamily
HXS80_RS02230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXS80_RS02230	COG1902	pentaerythritol trinitrate reductase activity
HXS80_RS02285	COG1280	lysine exporter protein (LysE YggA)
HXS80_RS02310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXS80_RS02325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HXS80_RS02360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXS80_RS02365	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS02370	COG2423	ornithine cyclodeaminase activity
HXS80_RS02375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXS80_RS02410	COG2197	response regulator
HXS80_RS02445	COG3851	Histidine kinase
HXS80_RS02450	COG2197	response regulator
HXS80_RS02460	COG3511	phospholipase C
HXS80_RS02475	COG0789	Transcriptional regulator
HXS80_RS02485	COG1733	regulation of RNA biosynthetic process
HXS80_RS02495	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS02505	COG3959	Transketolase, thiamine diphosphate binding domain
HXS80_RS02510	COG3958	Transketolase
HXS80_RS02560	COG0789	Transcriptional regulator
HXS80_RS02570	COG3467	pyridoxamine 5'-phosphate
HXS80_RS02615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXS80_RS02625	COG2755	lipolytic protein G-D-S-L family
HXS80_RS02665	COG1657	PFAM Prenyltransferase squalene oxidase
HXS80_RS02675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HXS80_RS02685	COG1562	ergosterol biosynthetic process
HXS80_RS02690	COG1134	teichoic acid transport
HXS80_RS02710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXS80_RS02740	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HXS80_RS02755	COG1024	Enoyl-CoA hydratase
HXS80_RS02765	COG4977	sequence-specific DNA binding
HXS80_RS02780	COG2226	methyltransferase
HXS80_RS02785	COG0488	(ABC) transporter
HXS80_RS02800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HXS80_RS02825	COG0789	Transcriptional regulator
HXS80_RS02830	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXS80_RS02830	COG1024	Enoyl-CoA hydratase
HXS80_RS02835	COG0183	Belongs to the thiolase family
HXS80_RS02840	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS02845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HXS80_RS02850	COG3268	Saccharopine dehydrogenase
HXS80_RS02860	COG1515	deoxyribonuclease V activity
HXS80_RS02885	COG0488	(ABC) transporter
HXS80_RS02900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXS80_RS02950	COG1793	dna ligase
HXS80_RS02955	COG2326	polyphosphate kinase activity
HXS80_RS02995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HXS80_RS03020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HXS80_RS03065	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS03080	COG3012	SEC-C Motif Domain Protein
HXS80_RS03110	COG1486	melibiose metabolic process
HXS80_RS03115	COG2124	cytochrome p450
HXS80_RS03165	COG1940	carbohydrate kinase activity
HXS80_RS03175	COG1070	Carbohydrate kinase
HXS80_RS03185	COG0488	(ABC) transporter
HXS80_RS03225	COG4176	ABC-type proline glycine betaine transport system permease component
HXS80_RS03230	COG0517	IMP dehydrogenase activity
HXS80_RS03230	COG4175	Glycine betaine
HXS80_RS03240	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS03265	COG0745	RESPONSE REGULATOR receiver
HXS80_RS03270	COG5002	protein histidine kinase activity
HXS80_RS03285	COG3568	Endonuclease Exonuclease Phosphatase
HXS80_RS03300	COG0714	Associated with various cellular activities
HXS80_RS03310	COG1869	D-ribose catabolic process
HXS80_RS03315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXS80_RS03320	COG1879	ABC-type sugar transport system periplasmic component
HXS80_RS03325	COG1129	ABC transporter
HXS80_RS03335	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS03340	COG0477	Major facilitator Superfamily
HXS80_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS03365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXS80_RS03370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXS80_RS03375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXS80_RS03380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS03415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS03440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS03445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXS80_RS03460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HXS80_RS03465	COG3321	synthase
HXS80_RS03465	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS03465	COG0300	oxidoreductase activity
HXS80_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS03465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXS80_RS03555	COG0084	hydrolase, TatD family'
HXS80_RS03570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HXS80_RS03590	COG0673	inositol 2-dehydrogenase activity
HXS80_RS03595	COG1879	ABC-type sugar transport system periplasmic component
HXS80_RS03600	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXS80_RS03605	COG1129	ABC transporter
HXS80_RS03615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXS80_RS03620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HXS80_RS03635	COG0656	L-ascorbic acid biosynthetic process
HXS80_RS03655	COG0300	oxidoreductase activity
HXS80_RS03660	COG4106	trans-aconitate 2-methyltransferase activity
HXS80_RS03680	COG2154	pterin-4-alpha-carbinolamine dehydratase
HXS80_RS03690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXS80_RS03690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXS80_RS03705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXS80_RS03760	COG1619	proteins homologs of microcin C7 resistance protein MccF
HXS80_RS03770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS03775	COG2362	D-Aminopeptidase
HXS80_RS03795	COG0667	Aldo Keto reductase
HXS80_RS03800	COG0583	DNA-binding transcription factor activity
HXS80_RS03830	COG0596	Alpha beta hydrolase
HXS80_RS03840	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXS80_RS03860	COG0604	alcohol dehydrogenase
HXS80_RS03865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HXS80_RS03865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HXS80_RS03870	COG2301	Belongs to the HpcH HpaI aldolase family
HXS80_RS03880	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS03885	COG0688	phosphatidylethanolamine metabolic process
HXS80_RS03920	COG1929	Belongs to the glycerate kinase type-1 family
HXS80_RS03955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HXS80_RS03975	COG0483	inositol monophosphate 1-phosphatase activity
HXS80_RS03985	COG1024	Enoyl-CoA hydratase
HXS80_RS03990	COG1131	(ABC) transporter
HXS80_RS04000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS04010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXS80_RS04015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXS80_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS04055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXS80_RS04060	COG1024	Enoyl-CoA hydratase
HXS80_RS04105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HXS80_RS04140	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS04145	COG1024	Enoyl-CoA hydratase
HXS80_RS04165	COG0095	Lipoate-protein ligase
HXS80_RS04220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXS80_RS04250	COG0405	Gamma-glutamyltransferase
HXS80_RS04255	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS04260	COG1309	transcriptional regulator
HXS80_RS04270	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS04290	COG0183	Belongs to the thiolase family
HXS80_RS04295	COG1024	Enoyl-CoA hydratase
HXS80_RS04295	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXS80_RS04310	COG0765	amino acid transport
HXS80_RS04315	COG0765	amino acid transport
HXS80_RS04320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXS80_RS04325	COG1126	abc transporter atp-binding protein
HXS80_RS04365	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXS80_RS04375	COG1940	carbohydrate kinase activity
HXS80_RS04380	COG1129	ABC transporter
HXS80_RS04395	COG2188	Transcriptional regulator
HXS80_RS04400	COG0673	inositol 2-dehydrogenase activity
HXS80_RS04415	COG2197	response regulator
HXS80_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS04440	COG0656	L-ascorbic acid biosynthetic process
HXS80_RS04450	COG4266	Belongs to the allantoicase family
HXS80_RS04455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXS80_RS04460	COG1414	Transcriptional regulator
HXS80_RS04480	COG2197	response regulator
HXS80_RS04520	COG1288	antiporter activity
HXS80_RS04545	COG2233	PERMEase
HXS80_RS04555	COG2233	PERMEase
HXS80_RS04565	COG2351	hydroxyisourate hydrolase activity
HXS80_RS04585	COG2706	6-phosphogluconolactonase activity
HXS80_RS04590	COG3622	Belongs to the hyi family
HXS80_RS04595	COG2084	Dehydrogenase
HXS80_RS04600	COG0753	catalase activity
HXS80_RS04625	COG3960	tartronate-semialdehyde synthase activity
HXS80_RS04645	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS04650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXS80_RS04655	COG2197	response regulator
HXS80_RS04670	COG0435	Glutathione S-transferase
HXS80_RS04700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS04725	COG3608	succinylglutamate desuccinylase aspartoacylase
HXS80_RS04725	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HXS80_RS04730	COG2252	PERMEase
HXS80_RS04735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HXS80_RS04760	COG1802	Transcriptional regulator
HXS80_RS04780	COG0028	Belongs to the TPP enzyme family
HXS80_RS04790	COG1404	Belongs to the peptidase S8 family
HXS80_RS04810	COG1162	GTPase activity
HXS80_RS04860	COG0183	Belongs to the thiolase family
HXS80_RS04865	COG0583	DNA-binding transcription factor activity
HXS80_RS04870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HXS80_RS04875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HXS80_RS04880	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXS80_RS04905	COG2814	Major facilitator Superfamily
HXS80_RS04915	COG0577	efflux transmembrane transporter activity
HXS80_RS04915	COG1136	(ABC) transporter
HXS80_RS04920	COG0583	DNA-binding transcription factor activity
HXS80_RS04945	COG1917	Cupin 2, conserved barrel domain protein
HXS80_RS04960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXS80_RS04965	COG3844	kynureninase activity
HXS80_RS05000	COG0175	sulfate reduction
HXS80_RS05005	COG0529	Catalyzes the synthesis of activated sulfate
HXS80_RS05025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HXS80_RS05030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HXS80_RS05040	COG2226	methyltransferase
HXS80_RS05050	COG1404	Belongs to the peptidase S8 family
HXS80_RS05070	COG1175	transmembrane transport
HXS80_RS05125	COG2723	6-phospho-beta-galactosidase activity
HXS80_RS05145	COG1072	(Pantothenic acid kinase))
HXS80_RS05150	COG0346	lactoylglutathione lyase activity
HXS80_RS05155	COG0583	DNA-binding transcription factor activity
HXS80_RS05160	COG0156	8-amino-7-oxononanoate synthase activity
HXS80_RS05165	COG1063	alcohol dehydrogenase
HXS80_RS05265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXS80_RS05270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXS80_RS05325	COG4152	abc transporter atp-binding protein
HXS80_RS05340	COG3220	belongs to the UPF0276 family
HXS80_RS05370	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXS80_RS05375	COG0745	RESPONSE REGULATOR receiver
HXS80_RS05390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HXS80_RS05415	COG0183	Belongs to the thiolase family
HXS80_RS05420	COG1024	Enoyl-CoA hydratase
HXS80_RS05420	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXS80_RS05435	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS05440	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS05445	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS05450	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS05470	COG0531	amino acid
HXS80_RS05475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HXS80_RS05480	COG4214	carbohydrate transport
HXS80_RS05490	COG4213	ABC transporter substrate-binding protein
HXS80_RS05495	COG1940	carbohydrate kinase activity
HXS80_RS05500	COG0395	ABC-type sugar transport system, permease component
HXS80_RS05505	COG1175	transmembrane transport
HXS80_RS05510	COG1653	transport
HXS80_RS05520	COG0588	phosphoglycerate mutase activity
HXS80_RS05535	COG0494	nUDIX hydrolase
HXS80_RS05545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HXS80_RS05575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXS80_RS05680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXS80_RS05725	COG0105	UTP biosynthetic process
HXS80_RS05735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXS80_RS05745	COG0667	Aldo Keto reductase
HXS80_RS05760	COG2197	response regulator
HXS80_RS05775	COG4948	Mandelate Racemase Muconate Lactonizing
HXS80_RS05810	COG5285	phytanoyl-CoA dioxygenase
HXS80_RS05825	COG2188	Transcriptional regulator
HXS80_RS05935	COG1073	alpha beta
HXS80_RS05940	COG1073	alpha beta
HXS80_RS05980	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXS80_RS06150	COG0714	Associated with various cellular activities
HXS80_RS06385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HXS80_RS06390	COG3285	dna ligase
HXS80_RS06390	COG1793	dna ligase
HXS80_RS06420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXS80_RS06425	COG1518	maintenance of DNA repeat elements
HXS80_RS06505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXS80_RS06525	COG0475	glutathione-regulated potassium exporter activity
HXS80_RS06550	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS06560	COG0300	oxidoreductase activity
HXS80_RS06570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXS80_RS06575	COG3903	Transcriptional regulator
HXS80_RS06575	COG3629	intracellular signal transduction
HXS80_RS06580	COG0477	Major facilitator Superfamily
HXS80_RS06620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXS80_RS06640	COG2197	response regulator
HXS80_RS06655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXS80_RS06660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXS80_RS06665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HXS80_RS06700	COG0489	protein tyrosine kinase activity
HXS80_RS06705	COG0297	glycogen (starch) synthase activity
HXS80_RS06720	COG1320	monovalent cation:proton antiporter activity
HXS80_RS06745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HXS80_RS06745	COG2111	Na H antiporter
HXS80_RS06785	COG1024	Enoyl-CoA hydratase
HXS80_RS06795	COG0531	amino acid
HXS80_RS06800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXS80_RS06810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HXS80_RS06820	COG2040	homocysteine
HXS80_RS06840	COG1799	cell septum assembly
HXS80_RS06845	COG1349	DNA-binding transcription factor activity
HXS80_RS06850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXS80_RS06855	COG0586	Pfam SNARE associated Golgi protein
HXS80_RS06865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS06870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS06895	COG3046	protein related to deoxyribodipyrimidine photolyase
HXS80_RS06900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXS80_RS06905	COG1280	lysine exporter protein (LysE YggA)
HXS80_RS06915	COG3291	Pkd domain containing protein
HXS80_RS06930	COG0601	transmembrane transport
HXS80_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXS80_RS06945	COG0006	proline dipeptidase activity
HXS80_RS06950	COG1802	Transcriptional regulator
HXS80_RS06955	COG2423	ornithine cyclodeaminase activity
HXS80_RS06965	COG3938	Belongs to the proline racemase family
HXS80_RS06975	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXS80_RS06985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXS80_RS06995	COG0596	Alpha beta hydrolase
HXS80_RS07010	COG2814	Major facilitator Superfamily
HXS80_RS07045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXS80_RS07065	COG4552	Acetyltransferase involved in intracellular survival and related
HXS80_RS07170	COG1201	RNA secondary structure unwinding
HXS80_RS07270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXS80_RS07275	COG0531	amino acid
HXS80_RS07280	COG0569	domain protein
HXS80_RS07310	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXS80_RS07310	COG1136	(ABC) transporter
HXS80_RS07320	COG0756	dUTP diphosphatase activity
HXS80_RS07345	COG2205	protein histidine kinase activity
HXS80_RS07350	COG0745	RESPONSE REGULATOR receiver
HXS80_RS07405	COG1435	thymidine kinase activity
HXS80_RS07420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXS80_RS07420	COG1042	CoA-binding domain protein
HXS80_RS07420	COG0045	succinate-CoA ligase (ADP-forming) activity
HXS80_RS07425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXS80_RS07430	COG1802	Transcriptional regulator
HXS80_RS07445	COG0612	Peptidase, M16
HXS80_RS07450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HXS80_RS07460	COG0372	Belongs to the citrate synthase family
HXS80_RS07465	COG0372	Belongs to the citrate synthase family
HXS80_RS07470	COG3290	protein histidine kinase activity
HXS80_RS07475	COG4565	transcriptional regulatory protein
HXS80_RS07480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXS80_RS07505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXS80_RS07510	COG2186	Transcriptional regulator
HXS80_RS07545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HXS80_RS07580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HXS80_RS07625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HXS80_RS07635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HXS80_RS07640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HXS80_RS07650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HXS80_RS07665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXS80_RS07670	COG2358	TRAP transporter, solute receptor (TAXI family
HXS80_RS07675	COG2205	protein histidine kinase activity
HXS80_RS07685	COG1126	abc transporter atp-binding protein
HXS80_RS07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXS80_RS07695	COG0765	amino acid transport
HXS80_RS07700	COG0765	amino acid transport
HXS80_RS07730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HXS80_RS07760	COG1917	Cupin 2, conserved barrel domain protein
HXS80_RS07760	COG2207	Transcriptional regulator
HXS80_RS07765	COG1201	RNA secondary structure unwinding
HXS80_RS07770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HXS80_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS07785	COG0783	Belongs to the Dps family
HXS80_RS07790	COG1396	sequence-specific DNA binding
HXS80_RS07795	COG1058	Belongs to the CinA family
HXS80_RS07795	COG1546	Belongs to the CinA family
HXS80_RS07805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXS80_RS07815	COG1674	ftsk spoiiie
HXS80_RS07825	COG3850	Histidine kinase
HXS80_RS07825	COG2205	protein histidine kinase activity
HXS80_RS07825	COG3437	response regulator, receiver
HXS80_RS07825	COG4999	Histidine kinase
HXS80_RS07855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HXS80_RS07860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXS80_RS07865	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HXS80_RS07885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HXS80_RS07890	COG0612	Peptidase, M16
HXS80_RS07895	COG1185	polyribonucleotide nucleotidyltransferase activity
HXS80_RS07900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HXS80_RS07910	COG1674	ftsk spoiiie
HXS80_RS07925	COG1404	Belongs to the peptidase S8 family
HXS80_RS07940	COG1404	Belongs to the peptidase S8 family
HXS80_RS07945	COG3266	domain, Protein
HXS80_RS07965	COG0455	bacterial-type flagellum organization
HXS80_RS07975	COG0601	transmembrane transport
HXS80_RS07980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXS80_RS08010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HXS80_RS08015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HXS80_RS08025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HXS80_RS08040	COG0779	Required for maturation of 30S ribosomal subunits
HXS80_RS08060	COG0442	prolyl-tRNA aminoacylation
HXS80_RS08075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HXS80_RS08080	COG0750	zinc metalloprotease
HXS80_RS08085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HXS80_RS08090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HXS80_RS08100	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS08105	COG2814	Major facilitator Superfamily
HXS80_RS08115	COG2508	Transcriptional regulator
HXS80_RS08145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXS80_RS08150	COG1177	transmembrane transport
HXS80_RS08155	COG1176	ABC-type spermidine putrescine transport system, permease component I
HXS80_RS08160	COG3842	ATPase activity
HXS80_RS08165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HXS80_RS08190	COG1595	DNA-templated transcription, initiation
HXS80_RS08230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXS80_RS08255	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS08265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HXS80_RS08270	COG1136	(ABC) transporter
HXS80_RS08280	COG3842	ATPase activity
HXS80_RS08295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HXS80_RS08305	COG2188	Transcriptional regulator
HXS80_RS08410	COG0575	Belongs to the CDS family
HXS80_RS08415	COG0233	cytoplasmic translational termination
HXS80_RS08420	COG0528	UMP kinase activity
HXS80_RS08425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HXS80_RS08430	COG0052	Belongs to the universal ribosomal protein uS2 family
HXS80_RS08445	COG1191	sigma factor activity
HXS80_RS08460	COG0792	nuclease activity
HXS80_RS08470	COG1051	belongs to the nudix hydrolase family
HXS80_RS08495	COG0335	large ribosomal subunit rRNA binding
HXS80_RS08500	COG0336	Belongs to the RNA methyltransferase TrmD family
HXS80_RS08505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HXS80_RS08510	COG1837	Belongs to the UPF0109 family
HXS80_RS08515	COG0228	four-way junction DNA binding
HXS80_RS08535	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HXS80_RS08570	COG0477	Major facilitator Superfamily
HXS80_RS08575	COG1196	nuclear chromosome segregation
HXS80_RS08585	COG1254	Belongs to the acylphosphatase family
HXS80_RS08590	COG2340	Cysteine-rich secretory protein family
HXS80_RS08595	COG1733	regulation of RNA biosynthetic process
HXS80_RS08600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HXS80_RS08605	COG0571	ribonuclease III activity
HXS80_RS08610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HXS80_RS08625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HXS80_RS08630	COG0742	ribosomal rna small subunit methyltransferase
HXS80_RS08640	COG1461	Dihydroxyacetone kinase
HXS80_RS08645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXS80_RS08650	COG0351	phosphomethylpyrimidine kinase
HXS80_RS08670	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXS80_RS08675	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HXS80_RS08690	COG0776	regulation of translation
HXS80_RS08700	COG0066	3-isopropylmalate dehydratase activity
HXS80_RS08705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HXS80_RS08710	COG1414	Transcriptional regulator
HXS80_RS08755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXS80_RS08760	COG0179	Fumarylacetoacetate (FAA) hydrolase
HXS80_RS08770	COG5002	protein histidine kinase activity
HXS80_RS08775	COG2018	Roadblock/LC7 domain
HXS80_RS08795	COG2018	Roadblock/LC7 domain
HXS80_RS08815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXS80_RS08820	COG1470	cell adhesion involved in biofilm formation
HXS80_RS08820	COG0366	Alpha amylase catalytic
HXS80_RS08840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXS80_RS08845	COG1120	ATPase activity
HXS80_RS08850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS08855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS08925	COG0492	ferredoxin-NADP+ reductase activity
HXS80_RS08945	COG2207	Transcriptional regulator
HXS80_RS08945	COG3708	Transcriptional regulator
HXS80_RS08960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HXS80_RS08995	COG0542	response to heat
HXS80_RS09040	COG1472	Belongs to the glycosyl hydrolase 3 family
HXS80_RS09045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXS80_RS09055	COG2957	Belongs to the agmatine deiminase family
HXS80_RS09065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HXS80_RS09070	COG0473	3-isopropylmalate dehydrogenase activity
HXS80_RS09085	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HXS80_RS09085	COG0778	Nitroreductase
HXS80_RS09090	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS09095	COG0506	proline dehydrogenase activity
HXS80_RS09100	COG2508	Transcriptional regulator
HXS80_RS09110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXS80_RS09130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXS80_RS09135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HXS80_RS09140	COG0440	acetolactate synthase activity
HXS80_RS09150	COG5001	Diguanylate cyclase
HXS80_RS09150	COG3300	MHYT domain
HXS80_RS09160	COG0667	Aldo Keto reductase
HXS80_RS09165	COG2133	pyrroloquinoline quinone binding
HXS80_RS09175	COG2197	response regulator
HXS80_RS09190	COG2409	Drug exporters of the RND superfamily
HXS80_RS09200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HXS80_RS09205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HXS80_RS09215	COG0154	amidase activity
HXS80_RS09220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HXS80_RS09230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXS80_RS09240	COG4221	oxidoreductase activity
HXS80_RS09260	COG0482	sulfurtransferase activity
HXS80_RS09290	COG2378	regulation of single-species biofilm formation
HXS80_RS09300	COG2860	membrane
HXS80_RS09305	COG4608	Belongs to the ABC transporter superfamily
HXS80_RS09325	COG0747	negative chemotaxis
HXS80_RS09345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HXS80_RS09350	COG0509	glycine decarboxylation via glycine cleavage system
HXS80_RS09355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HXS80_RS09360	COG1760	l-serine dehydratase
HXS80_RS09395	COG0367	asparagine synthase
HXS80_RS09405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS09505	COG2197	response regulator
HXS80_RS09520	COG1131	(ABC) transporter
HXS80_RS09530	COG1132	(ABC) transporter
HXS80_RS09540	COG1742	UPF0060 membrane protein
HXS80_RS09555	COG0387	Pfam Sodium calcium exchanger
HXS80_RS09585	COG0058	SHG alpha-glucan phosphorylase activity
HXS80_RS09590	COG0366	Alpha amylase catalytic
HXS80_RS09595	COG0366	Alpha amylase catalytic
HXS80_RS09605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HXS80_RS09620	COG1301	dicarboxylic acid transport
HXS80_RS09625	COG3290	protein histidine kinase activity
HXS80_RS09630	COG4565	transcriptional regulatory protein
HXS80_RS09640	COG0205	6-phosphofructokinase activity
HXS80_RS09645	COG0857	belongs to the CobB CobQ family
HXS80_RS09645	COG0280	phosphate acetyltransferase
HXS80_RS09650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HXS80_RS09695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HXS80_RS09695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HXS80_RS09765	COG5000	phosphorelay sensor kinase activity
HXS80_RS09765	COG5002	protein histidine kinase activity
HXS80_RS09770	COG0745	RESPONSE REGULATOR receiver
HXS80_RS09785	COG0183	Belongs to the thiolase family
HXS80_RS09805	COG1131	(ABC) transporter
HXS80_RS09840	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HXS80_RS09855	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXS80_RS09880	COG4585	Histidine kinase
HXS80_RS09885	COG2197	response regulator
HXS80_RS09900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HXS80_RS09905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HXS80_RS09910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HXS80_RS09915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HXS80_RS09920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HXS80_RS09925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HXS80_RS09930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HXS80_RS09950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HXS80_RS09955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HXS80_RS09965	COG2890	protein-(glutamine-N5) methyltransferase activity
HXS80_RS09970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HXS80_RS09975	COG0254	rRNA binding
HXS80_RS09980	COG1316	TRANSCRIPTIONal
HXS80_RS09990	COG0083	homoserine kinase activity
HXS80_RS09995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HXS80_RS10000	COG0460	homoserine dehydrogenase
HXS80_RS10005	COG0019	diaminopimelate decarboxylase activity
HXS80_RS10010	COG0018	arginyl-trna synthetase
HXS80_RS10035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HXS80_RS10045	COG0515	serine threonine protein kinase
HXS80_RS10050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HXS80_RS10055	COG1793	dna ligase
HXS80_RS10055	COG3285	dna ligase
HXS80_RS10075	COG2205	protein histidine kinase activity
HXS80_RS10125	COG1309	transcriptional regulator
HXS80_RS10165	COG5002	protein histidine kinase activity
HXS80_RS10185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HXS80_RS10195	COG0745	RESPONSE REGULATOR receiver
HXS80_RS10200	COG2205	protein histidine kinase activity
HXS80_RS10205	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXS80_RS10205	COG0567	Dehydrogenase, E1 component
HXS80_RS10230	COG0542	response to heat
HXS80_RS10250	COG0604	alcohol dehydrogenase
HXS80_RS10255	COG0281	malic enzyme
HXS80_RS10260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXS80_RS10265	COG0765	amino acid transport
HXS80_RS10270	COG1126	abc transporter atp-binding protein
HXS80_RS10280	COG1595	DNA-templated transcription, initiation
HXS80_RS10285	COG4106	trans-aconitate 2-methyltransferase activity
HXS80_RS10305	COG0582	viral genome integration into host DNA
HXS80_RS10335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HXS80_RS10395	COG1695	Transcriptional regulator
HXS80_RS10415	COG4585	Histidine kinase
HXS80_RS10420	COG2197	response regulator
HXS80_RS10490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXS80_RS10495	COG1959	2 iron, 2 sulfur cluster binding
HXS80_RS10535	COG1597	lipid kinase activity
HXS80_RS10550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXS80_RS10555	COG0363	glucosamine-6-phosphate deaminase activity
HXS80_RS10560	COG1472	Belongs to the glycosyl hydrolase 3 family
HXS80_RS10565	COG0395	ABC-type sugar transport system, permease component
HXS80_RS10570	COG1175	transmembrane transport
HXS80_RS10575	COG2182	Extracellular solute-binding protein
HXS80_RS10580	COG2188	Transcriptional regulator
HXS80_RS10585	COG1966	Carbon starvation protein
HXS80_RS10620	COG0242	peptide deformylase activity
HXS80_RS10630	COG5662	AntiSigma factor
HXS80_RS10635	COG1595	DNA-templated transcription, initiation
HXS80_RS10645	COG2135	peptidase activity
HXS80_RS10655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HXS80_RS10665	COG2076	Multidrug Resistance protein
HXS80_RS10675	COG0483	inositol monophosphate 1-phosphatase activity
HXS80_RS10685	COG0753	catalase activity
HXS80_RS10710	COG1615	UPF0182 protein
HXS80_RS10720	COG3480	Lon protease (S16) C-terminal proteolytic domain
HXS80_RS10815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS10820	COG0210	DNA helicase
HXS80_RS10880	COG0747	negative chemotaxis
HXS80_RS10920	COG0513	Belongs to the DEAD box helicase family
HXS80_RS10930	COG1432	Conserved Protein
HXS80_RS10940	COG2095	MarC family integral membrane protein
HXS80_RS10955	COG2814	Major facilitator Superfamily
HXS80_RS10965	COG0598	Magnesium transport protein CorA
HXS80_RS11000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXS80_RS11005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS80_RS11015	COG1595	DNA-templated transcription, initiation
HXS80_RS11030	COG1024	Enoyl-CoA hydratase
HXS80_RS11035	COG0519	Catalyzes the synthesis of GMP from XMP
HXS80_RS11045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HXS80_RS11050	COG1611	Belongs to the LOG family
HXS80_RS11055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS11085	COG2912	Transglutaminase-like superfamily
HXS80_RS11090	COG2197	response regulator
HXS80_RS11095	COG1132	(ABC) transporter
HXS80_RS11110	COG0515	serine threonine protein kinase
HXS80_RS11125	COG0110	maltose O-acetyltransferase activity
HXS80_RS11145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXS80_RS11160	COG4608	Belongs to the ABC transporter superfamily
HXS80_RS11175	COG0601	transmembrane transport
HXS80_RS11180	COG4166	transmembrane transport
HXS80_RS11185	COG4608	Belongs to the ABC transporter superfamily
HXS80_RS11195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXS80_RS11200	COG0601	transmembrane transport
HXS80_RS11225	COG0154	amidase activity
HXS80_RS11230	COG2197	response regulator
HXS80_RS11235	COG4585	Histidine kinase
HXS80_RS11240	COG2409	Drug exporters of the RND superfamily
HXS80_RS11255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HXS80_RS11305	COG0789	Transcriptional regulator
HXS80_RS11410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXS80_RS11420	COG0477	Major facilitator Superfamily
HXS80_RS11440	COG0012	GTP binding
HXS80_RS11455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HXS80_RS11465	COG1570	exodeoxyribonuclease VII activity
HXS80_RS11470	COG1722	exodeoxyribonuclease VII activity
HXS80_RS11475	COG0778	Nitroreductase
HXS80_RS11500	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HXS80_RS11500	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HXS80_RS11535	COG1362	aminopeptidase activity
HXS80_RS11545	COG0114	fumarate hydratase activity
HXS80_RS11560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXS80_RS11560	COG4499	WXG100 protein secretion system (Wss), protein YukC
HXS80_RS11575	COG1136	(ABC) transporter
HXS80_RS11605	COG0450	alkyl hydroperoxide reductase
HXS80_RS11610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXS80_RS11625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HXS80_RS11630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXS80_RS11635	COG0667	Aldo Keto reductase
HXS80_RS11645	COG2226	methyltransferase
HXS80_RS11680	COG2885	chlorophyll binding
HXS80_RS11700	COG2197	response regulator
HXS80_RS11735	COG2894	cell division
HXS80_RS11770	COG2610	gluconate transmembrane transporter activity
HXS80_RS11775	COG0251	oxidation-reduction process
HXS80_RS11780	COG1414	Transcriptional regulator
HXS80_RS11795	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HXS80_RS11815	COG1733	regulation of RNA biosynthetic process
HXS80_RS11835	COG0436	Aminotransferase
HXS80_RS11845	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HXS80_RS11855	COG1331	Highly conserved protein containing a thioredoxin domain
HXS80_RS11900	COG4581	dead DEAH box helicase
HXS80_RS11910	COG1331	Highly conserved protein containing a thioredoxin domain
HXS80_RS11935	COG4585	Histidine kinase
HXS80_RS11945	COG1136	(ABC) transporter
HXS80_RS11945	COG0577	efflux transmembrane transporter activity
HXS80_RS11950	COG2197	response regulator
HXS80_RS12000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXS80_RS12010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HXS80_RS12025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HXS80_RS12035	COG1366	Belongs to the anti-sigma-factor antagonist family
HXS80_RS12040	COG1366	Belongs to the anti-sigma-factor antagonist family
HXS80_RS12045	COG2172	sigma factor antagonist activity
HXS80_RS12055	COG0784	Response regulator, receiver
HXS80_RS12055	COG2198	Histidine kinase
HXS80_RS12055	COG5002	protein histidine kinase activity
HXS80_RS12060	COG0745	RESPONSE REGULATOR receiver
HXS80_RS12065	COG1595	DNA-templated transcription, initiation
HXS80_RS12105	COG0583	DNA-binding transcription factor activity
HXS80_RS12110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXS80_RS12125	COG1396	sequence-specific DNA binding
HXS80_RS12130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HXS80_RS12150	COG1376	ErfK ybiS ycfS ynhG family protein
HXS80_RS12175	COG1024	Enoyl-CoA hydratase
HXS80_RS12190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXS80_RS12200	COG0424	maF-like protein
HXS80_RS12210	COG4770	biotin carboxylase activity
HXS80_RS12240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXS80_RS12255	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS12260	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS12275	COG1595	DNA-templated transcription, initiation
HXS80_RS12280	COG0745	RESPONSE REGULATOR receiver
HXS80_RS12285	COG2205	protein histidine kinase activity
HXS80_RS12310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXS80_RS12330	COG0583	DNA-binding transcription factor activity
HXS80_RS12335	COG2814	Major facilitator Superfamily
HXS80_RS12355	COG1404	Belongs to the peptidase S8 family
HXS80_RS12395	COG1473	amidohydrolase
HXS80_RS12395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HXS80_RS12405	COG2089	acid synthase
HXS80_RS12410	COG1083	cytidylyl-transferase
HXS80_RS12420	COG1216	Glycosyl transferase, family 2
HXS80_RS12450	COG1595	DNA-templated transcription, initiation
HXS80_RS12455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXS80_RS12490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HXS80_RS12495	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HXS80_RS12500	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HXS80_RS12550	COG2009	succinate dehydrogenase
HXS80_RS12560	COG1053	succinate dehydrogenase
HXS80_RS12565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HXS80_RS12600	COG1408	metallophosphoesterase
HXS80_RS12615	COG1295	ribonuclease BN
HXS80_RS12635	COG0180	Tryptophanyl-tRNA synthetase
HXS80_RS12640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXS80_RS12645	COG0754	glutathionylspermidine amidase activity
HXS80_RS12655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXS80_RS12660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXS80_RS12680	COG0039	L-malate dehydrogenase activity
HXS80_RS12695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HXS80_RS12710	COG0138	bifunctional purine biosynthesis protein purh
HXS80_RS12740	COG0045	succinate-CoA ligase (ADP-forming) activity
HXS80_RS12745	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HXS80_RS12755	COG0714	Associated with various cellular activities
HXS80_RS12775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HXS80_RS12785	COG0739	heme binding
HXS80_RS12805	COG0791	NLP P60 protein
HXS80_RS12810	COG2197	response regulator
HXS80_RS12850	COG0519	Catalyzes the synthesis of GMP from XMP
HXS80_RS12850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HXS80_RS12870	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS12875	COG0515	serine threonine protein kinase
HXS80_RS12905	COG0516	GMP reductase activity
HXS80_RS12915	COG1595	DNA-templated transcription, initiation
HXS80_RS12930	COG0583	DNA-binding transcription factor activity
HXS80_RS12945	COG2132	Multicopper oxidase
HXS80_RS12960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HXS80_RS12970	COG0726	polysaccharide deacetylase
HXS80_RS13005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HXS80_RS13030	COG0802	atpase or kinase
HXS80_RS13045	COG3189	MarR family transcriptional regulator
HXS80_RS13055	COG0736	holo-[acyl-carrier-protein] synthase activity
HXS80_RS13060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXS80_RS13125	COG1072	(Pantothenic acid kinase))
HXS80_RS13135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXS80_RS13140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HXS80_RS13145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HXS80_RS13150	COG0488	(ABC) transporter
HXS80_RS13160	COG0101	tRNA pseudouridine synthase activity
HXS80_RS13165	COG0203	ribosomal protein L17
HXS80_RS13170	COG0202	RNA polymerase activity
HXS80_RS13175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HXS80_RS13180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HXS80_RS13185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXS80_RS13190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HXS80_RS13200	COG0563	adenylate kinase activity
HXS80_RS13210	COG0200	Binds to the 23S rRNA
HXS80_RS13215	COG1841	ribosomal large subunit assembly
HXS80_RS13220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HXS80_RS13225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HXS80_RS13230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HXS80_RS13235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HXS80_RS13240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXS80_RS13245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HXS80_RS13250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HXS80_RS13255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HXS80_RS13260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HXS80_RS13265	COG0255	Belongs to the universal ribosomal protein uL29 family
HXS80_RS13270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HXS80_RS13275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HXS80_RS13280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HXS80_RS13285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HXS80_RS13290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HXS80_RS13295	COG0089	rRNA binding
HXS80_RS13300	COG0088	Forms part of the polypeptide exit tunnel
HXS80_RS13305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HXS80_RS13310	COG0051	transcription antitermination factor activity, RNA binding
HXS80_RS13325	COG2197	response regulator
HXS80_RS13330	COG4585	Histidine kinase
HXS80_RS13335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXS80_RS13340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXS80_RS13345	COG0049	tRNA binding
HXS80_RS13350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HXS80_RS13365	COG0739	heme binding
HXS80_RS13365	COG0741	lytic transglycosylase activity
HXS80_RS13365	COG1196	nuclear chromosome segregation
HXS80_RS13455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HXS80_RS13460	COG0085	RNA polymerase activity
HXS80_RS13465	COG0222	ribosome binding
HXS80_RS13470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HXS80_RS13480	COG0081	regulation of translation
HXS80_RS13485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HXS80_RS13505	COG0436	Aminotransferase
HXS80_RS13510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXS80_RS13515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HXS80_RS13535	COG2030	dehydratase
HXS80_RS13540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXS80_RS13560	COG0702	epimerase
HXS80_RS13570	COG1666	GTP binding
HXS80_RS13575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HXS80_RS13590	COG3304	Inner membrane component domain
HXS80_RS13595	COG0501	Belongs to the peptidase M48B family
HXS80_RS13600	COG1970	mechanosensitive ion channel activity
HXS80_RS13605	COG1007	ATP synthesis coupled electron transport
HXS80_RS13620	COG0713	ATP synthesis coupled electron transport
HXS80_RS13630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS80_RS13635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HXS80_RS13640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS80_RS13650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS80_RS13665	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXS80_RS13665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXS80_RS13670	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXS80_RS13675	COG1733	regulation of RNA biosynthetic process
HXS80_RS13680	COG0702	epimerase
HXS80_RS13775	COG0561	phosphatase activity
HXS80_RS13805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXS80_RS13805	COG0515	serine threonine protein kinase
HXS80_RS13835	COG3104	oligopeptide transport
HXS80_RS13870	COG0514	ATP-dependent DNA helicase (RecQ)
HXS80_RS13875	COG1007	ATP synthesis coupled electron transport
HXS80_RS13885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HXS80_RS13890	COG0713	ATP synthesis coupled electron transport
HXS80_RS13895	COG0839	Belongs to the complex I subunit 6 family
HXS80_RS13900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS80_RS13905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HXS80_RS13910	COG1034	ATP synthesis coupled electron transport
HXS80_RS13915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HXS80_RS13925	COG0649	NAD binding
HXS80_RS13930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS80_RS13935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS80_RS14005	COG2226	methyltransferase
HXS80_RS14010	COG2175	clavaminate synthase activity
HXS80_RS14020	COG4521	taurine ABC transporter
HXS80_RS14025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HXS80_RS14050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HXS80_RS14060	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HXS80_RS14080	COG1404	Belongs to the peptidase S8 family
HXS80_RS14125	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS14140	COG1024	Enoyl-CoA hydratase
HXS80_RS14165	COG1309	transcriptional regulator
HXS80_RS14175	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS14195	COG0501	Belongs to the peptidase M48B family
HXS80_RS14215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS14220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS14225	COG4592	Periplasmic binding protein
HXS80_RS14230	COG2072	flavoprotein involved in K transport
HXS80_RS14240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXS80_RS14265	COG1024	Enoyl-CoA hydratase
HXS80_RS14270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HXS80_RS14315	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS14335	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS14340	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS14350	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS14365	COG1366	Belongs to the anti-sigma-factor antagonist family
HXS80_RS14430	COG4821	SIS domain
HXS80_RS14445	COG0259	pyridoxamine-phosphate oxidase activity
HXS80_RS14465	COG1396	sequence-specific DNA binding
HXS80_RS14480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HXS80_RS14500	COG2814	Major facilitator Superfamily
HXS80_RS14510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HXS80_RS14515	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HXS80_RS14525	COG1278	Cold shock
HXS80_RS14550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS14555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS14560	COG1120	ATPase activity
HXS80_RS14565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXS80_RS14605	COG1061	Type III restriction enzyme res subunit
HXS80_RS14615	COG1120	ATPase activity
HXS80_RS14640	COG3973	AAA domain
HXS80_RS14660	COG1984	allophanate hydrolase subunit 2
HXS80_RS14670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HXS80_RS14680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXS80_RS14685	COG0640	Transcriptional regulator
HXS80_RS14710	COG1737	Transcriptional regulator
HXS80_RS14715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HXS80_RS14720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXS80_RS14720	COG1263	PTS System
HXS80_RS14740	COG4257	antibiotic catabolic process
HXS80_RS14785	COG2154	pterin-4-alpha-carbinolamine dehydratase
HXS80_RS14810	COG0789	Transcriptional regulator
HXS80_RS14815	COG1819	glycosyl
HXS80_RS14830	COG2204	response regulator
HXS80_RS14835	COG4251	negative regulation of phosphorylation
HXS80_RS14870	COG1175	transmembrane transport
HXS80_RS14875	COG0395	ABC-type sugar transport system, permease component
HXS80_RS14895	COG0583	DNA-binding transcription factor activity
HXS80_RS14920	COG2318	DinB family
HXS80_RS14930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HXS80_RS14950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXS80_RS14995	COG1595	DNA-templated transcription, initiation
HXS80_RS15005	COG1132	(ABC) transporter
HXS80_RS15055	COG0463	Glycosyl transferase, family 2
HXS80_RS15060	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HXS80_RS15070	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HXS80_RS15095	COG2197	response regulator
HXS80_RS15130	COG1131	(ABC) transporter
HXS80_RS15145	COG0577	efflux transmembrane transporter activity
HXS80_RS15145	COG1136	(ABC) transporter
HXS80_RS15155	COG2197	response regulator
HXS80_RS15170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HXS80_RS15175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXS80_RS15180	COG1754	DNA topoisomerase type I activity
HXS80_RS15180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HXS80_RS15190	COG2890	protein-(glutamine-N5) methyltransferase activity
HXS80_RS15200	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HXS80_RS15210	COG1366	Belongs to the anti-sigma-factor antagonist family
HXS80_RS15215	COG1111	helicase
HXS80_RS15215	COG1205	dead DEAH box helicase
HXS80_RS15275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXS80_RS15280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXS80_RS15290	COG2267	carboxylic ester hydrolase activity
HXS80_RS15315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXS80_RS15325	COG0251	oxidation-reduction process
HXS80_RS15340	COG0003	Pfam Anion-transporting ATPase
HXS80_RS15350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HXS80_RS15355	COG1610	YqeY-like protein
HXS80_RS15360	COG1408	metallophosphoesterase
HXS80_RS15375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXS80_RS15380	COG2755	lipolytic protein G-D-S-L family
HXS80_RS15390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXS80_RS15410	COG1595	DNA-templated transcription, initiation
HXS80_RS15440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HXS80_RS15490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HXS80_RS15495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HXS80_RS15510	COG1802	Transcriptional regulator
HXS80_RS15515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HXS80_RS15520	COG0693	protein deglycase activity
HXS80_RS15530	COG2124	cytochrome p450
HXS80_RS15540	COG0738	Major facilitator superfamily
HXS80_RS15545	COG3226	Transcriptional regulator
HXS80_RS15550	COG0667	Aldo Keto reductase
HXS80_RS15575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXS80_RS15585	COG0662	Cupin 2, conserved barrel domain protein
HXS80_RS15590	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS15645	COG0590	tRNA wobble adenosine to inosine editing
HXS80_RS15655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HXS80_RS15685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HXS80_RS15690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HXS80_RS15710	COG2124	cytochrome p450
HXS80_RS15715	COG2197	response regulator
HXS80_RS15720	COG4585	Histidine kinase
HXS80_RS15735	COG3844	kynureninase activity
HXS80_RS15750	COG0477	Major facilitator Superfamily
HXS80_RS15755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXS80_RS15760	COG0191	fructose-bisphosphate aldolase activity
HXS80_RS15765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HXS80_RS15780	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HXS80_RS15960	COG0270	DNA (cytosine-5-)-methyltransferase activity
HXS80_RS16060	COG0542	response to heat
HXS80_RS16100	COG0789	Transcriptional regulator
HXS80_RS16105	COG0484	heat shock protein binding
HXS80_RS16110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HXS80_RS16115	COG0443	Heat shock 70 kDa protein
HXS80_RS16120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXS80_RS16125	COG0247	lactate metabolic process
HXS80_RS16125	COG2181	nitrate reductase activity
HXS80_RS16145	COG0717	Belongs to the dCTP deaminase family
HXS80_RS16160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HXS80_RS16240	COG1309	transcriptional regulator
HXS80_RS16245	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS16310	COG2205	protein histidine kinase activity
HXS80_RS16390	COG0475	glutathione-regulated potassium exporter activity
HXS80_RS16400	COG0513	Belongs to the DEAD box helicase family
HXS80_RS16405	COG1278	Cold shock
HXS80_RS16455	COG0450	alkyl hydroperoxide reductase
HXS80_RS16465	COG2268	Band 7 protein
HXS80_RS16500	COG0490	domain, Protein
HXS80_RS16505	COG0475	glutathione-regulated potassium exporter activity
HXS80_RS16510	COG0181	hydroxymethylbilane synthase activity
HXS80_RS16535	COG2255	four-way junction helicase activity
HXS80_RS16545	COG0180	Tryptophanyl-tRNA synthetase
HXS80_RS16550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS16585	COG0431	NADPH-dependent FMN reductase
HXS80_RS16610	COG2304	oxidoreductase activity
HXS80_RS16615	COG2205	protein histidine kinase activity
HXS80_RS16620	COG0745	RESPONSE REGULATOR receiver
HXS80_RS16625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXS80_RS16640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HXS80_RS16655	COG1741	Belongs to the pirin family
HXS80_RS16665	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS16675	COG1362	aminopeptidase activity
HXS80_RS16685	COG3903	Transcriptional regulator
HXS80_RS16685	COG3629	intracellular signal transduction
HXS80_RS16710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXS80_RS16720	COG2271	Major facilitator Superfamily
HXS80_RS16735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXS80_RS16740	COG0022	dehydrogenase e1 component
HXS80_RS16765	COG0515	serine threonine protein kinase
HXS80_RS16770	COG0515	serine threonine protein kinase
HXS80_RS16785	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXS80_RS16785	COG1136	(ABC) transporter
HXS80_RS16810	COG0303	'Molybdopterin
HXS80_RS16835	COG1522	sequence-specific DNA binding
HXS80_RS16840	COG1309	transcriptional regulator
HXS80_RS16865	COG3396	Phenylacetate-CoA oxygenase
HXS80_RS16870	COG3460	Phenylacetate-CoA oxygenase
HXS80_RS16875	COG3396	Phenylacetate-CoA oxygenase
HXS80_RS16880	COG2151	metal-sulfur cluster biosynthetic enzyme
HXS80_RS16885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXS80_RS16920	COG1716	ATPase activity
HXS80_RS16925	COG1716	ATPase activity
HXS80_RS16940	COG0768	penicillin binding
HXS80_RS16945	COG0515	serine threonine protein kinase
HXS80_RS16950	COG3764	Sortase (surface protein transpeptidase)
HXS80_RS16955	COG3764	Sortase (surface protein transpeptidase)
HXS80_RS16970	COG3764	Sortase (surface protein transpeptidase)
HXS80_RS17010	COG0515	serine threonine protein kinase
HXS80_RS17040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HXS80_RS17050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HXS80_RS17055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HXS80_RS17060	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HXS80_RS17065	COG0592	DNA-directed DNA polymerase activity
HXS80_RS17080	COG0594	ribonuclease P activity
HXS80_RS17090	COG0706	membrane insertase activity
HXS80_RS17100	COG0357	Ribosomal RNA small subunit methyltransferase G
HXS80_RS17105	COG1192	Involved in chromosome partitioning
HXS80_RS17120	COG3118	belongs to the thioredoxin family
HXS80_RS17125	COG0492	ferredoxin-NADP+ reductase activity
HXS80_RS17135	COG1595	DNA-templated transcription, initiation
HXS80_RS17140	COG2815	serine threonine protein kinase
HXS80_RS17140	COG0515	serine threonine protein kinase
HXS80_RS17175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXS80_RS17200	COG0360	Binds together with S18 to 16S ribosomal RNA
HXS80_RS17205	COG0629	single-stranded DNA binding
HXS80_RS17210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HXS80_RS17215	COG0359	binds to the 23S rRNA
HXS80_RS17225	COG0305	Participates in initiation and elongation during chromosome replication
HXS80_RS17255	COG2814	Major facilitator Superfamily
HXS80_RS17270	COG0626	cystathionine gamma-synthase activity
HXS80_RS17275	COG1950	PFAM Membrane protein of
HXS80_RS17280	COG0662	Cupin 2, conserved barrel domain protein
HXS80_RS17305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HXS80_RS17315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HXS80_RS17320	COG1609	Transcriptional regulator
HXS80_RS17325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXS80_RS17330	COG1271	oxidase subunit
HXS80_RS17335	COG1294	oxidase, subunit
HXS80_RS17340	COG4988	ABC transporter
HXS80_RS17350	COG0561	phosphatase activity
HXS80_RS17360	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HXS80_RS17365	COG0789	Transcriptional regulator
HXS80_RS17380	COG1131	(ABC) transporter
HXS80_RS17405	COG0561	phosphatase activity
HXS80_RS17410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HXS80_RS17420	COG2837	iron assimilation
HXS80_RS17425	COG2372	response to copper ion
HXS80_RS17435	COG1999	signal sequence binding
HXS80_RS17455	COG0006	proline dipeptidase activity
HXS80_RS17470	COG0653	protein targeting
HXS80_RS17510	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS17535	COG1595	DNA-templated transcription, initiation
HXS80_RS17540	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS17585	COG1252	NADH dehydrogenase
HXS80_RS17590	COG1595	DNA-templated transcription, initiation
HXS80_RS17610	COG0745	RESPONSE REGULATOR receiver
HXS80_RS17630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HXS80_RS17630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HXS80_RS17640	COG0477	Major facilitator Superfamily
HXS80_RS17660	COG2353	YceI-like domain
HXS80_RS17685	COG1191	sigma factor activity
HXS80_RS17690	COG1191	sigma factor activity
HXS80_RS17715	COG1518	maintenance of DNA repeat elements
HXS80_RS17770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HXS80_RS17785	COG2234	aminopeptidase activity
HXS80_RS17820	COG0464	growth
HXS80_RS17900	COG4941	Belongs to the sigma-70 factor family
HXS80_RS17955	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HXS80_RS18170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXS80_RS18200	COG0525	valine-tRNA ligase activity
HXS80_RS18235	COG0151	Belongs to the GarS family
HXS80_RS18250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HXS80_RS18275	COG1131	(ABC) transporter
HXS80_RS18295	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HXS80_RS18300	COG0047	phosphoribosylformylglycinamidine synthase activity
HXS80_RS18305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HXS80_RS18315	COG1196	nuclear chromosome segregation
HXS80_RS18315	COG0739	heme binding
HXS80_RS18315	COG0741	lytic transglycosylase activity
HXS80_RS18330	COG3119	arylsulfatase activity
HXS80_RS18340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HXS80_RS18350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HXS80_RS18370	COG1643	Atp-dependent helicase
HXS80_RS18380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXS80_RS18380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HXS80_RS18385	COG0785	Cytochrome C biogenesis protein
HXS80_RS18420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HXS80_RS18430	COG0513	Belongs to the DEAD box helicase family
HXS80_RS18440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HXS80_RS18505	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS18555	COG1937	Protein conserved in bacteria
HXS80_RS18570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXS80_RS18570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXS80_RS18575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXS80_RS18580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HXS80_RS18600	COG1196	nuclear chromosome segregation
HXS80_RS18600	COG0739	heme binding
HXS80_RS18600	COG0741	lytic transglycosylase activity
HXS80_RS18615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HXS80_RS18620	COG0579	oxidoreductase
HXS80_RS18645	COG1252	NADH dehydrogenase
HXS80_RS18660	COG1846	Transcriptional regulator
HXS80_RS18680	COG2197	response regulator
HXS80_RS18685	COG4585	Histidine kinase
HXS80_RS18695	COG1131	(ABC) transporter
HXS80_RS18765	COG0739	heme binding
HXS80_RS18765	COG0741	lytic transglycosylase activity
HXS80_RS18765	COG1196	nuclear chromosome segregation
HXS80_RS18770	COG0671	phosphoesterase, PA-phosphatase related
HXS80_RS18790	COG1937	Protein conserved in bacteria
HXS80_RS18800	COG0306	phosphate transporter
HXS80_RS18820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HXS80_RS18845	COG1116	anion transmembrane transporter activity
HXS80_RS18850	COG1725	Transcriptional regulator
HXS80_RS18855	COG0456	acetyltransferase
HXS80_RS18865	COG0737	Belongs to the 5'-nucleotidase family
HXS80_RS18875	COG0154	amidase activity
HXS80_RS18890	COG4977	sequence-specific DNA binding
HXS80_RS18905	COG0739	heme binding
HXS80_RS18940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS80_RS18945	COG1609	Transcriptional regulator
HXS80_RS18950	COG0745	RESPONSE REGULATOR receiver
HXS80_RS18975	COG2897	thiosulfate sulfurtransferase activity
HXS80_RS19010	COG3485	protocatechuate 3,4-dioxygenase
HXS80_RS19025	COG1490	D-aminoacyl-tRNA deacylase activity
HXS80_RS19040	COG4552	Acetyltransferase involved in intracellular survival and related
HXS80_RS19155	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS19200	COG0640	Transcriptional regulator
HXS80_RS19205	COG0798	PFAM Bile acid sodium symporter
HXS80_RS19210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HXS80_RS19215	COG0456	acetyltransferase
HXS80_RS19220	COG0588	phosphoglycerate mutase activity
HXS80_RS19240	COG5002	protein histidine kinase activity
HXS80_RS19255	COG1329	Transcriptional regulator
HXS80_RS19260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HXS80_RS19265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HXS80_RS19280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXS80_RS19290	COG3467	pyridoxamine 5'-phosphate
HXS80_RS19295	COG0215	cysteine-tRNA ligase activity
HXS80_RS19320	COG3842	ATPase activity
HXS80_RS19380	COG0745	RESPONSE REGULATOR receiver
HXS80_RS19425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXS80_RS19445	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HXS80_RS19465	COG2197	response regulator
HXS80_RS19470	COG4585	Histidine kinase
HXS80_RS19500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HXS80_RS19525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXS80_RS19535	COG1653	transport
HXS80_RS19595	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS19625	COG0076	glutamate decarboxylase activity
HXS80_RS19630	COG0655	NAD(P)H dehydrogenase (quinone) activity
HXS80_RS19640	COG0586	Pfam SNARE associated Golgi protein
HXS80_RS19650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HXS80_RS19655	COG2027	D-alanyl-D-alanine carboxypeptidase
HXS80_RS19665	COG0037	tRNA processing
HXS80_RS19680	COG0302	gtp cyclohydrolase
HXS80_RS19695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HXS80_RS19710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HXS80_RS19710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HXS80_RS19720	COG0517	IMP dehydrogenase activity
HXS80_RS19720	COG1125	glycine betaine transport
HXS80_RS19725	COG1174	glycine betaine transport
HXS80_RS19730	COG1174	glycine betaine transport
HXS80_RS19745	COG0649	NAD binding
HXS80_RS19760	COG2197	response regulator
HXS80_RS19775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HXS80_RS19780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HXS80_RS19790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HXS80_RS19810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HXS80_RS19840	COG0739	heme binding
HXS80_RS19845	COG2205	protein histidine kinase activity
HXS80_RS19850	COG0745	RESPONSE REGULATOR receiver
HXS80_RS19860	COG1595	DNA-templated transcription, initiation
HXS80_RS19865	COG1194	a g-specific adenine glycosylase
HXS80_RS19875	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HXS80_RS19895	COG0248	Ppx GppA phosphatase
HXS80_RS19900	COG1082	Xylose isomerase domain protein TIM barrel
HXS80_RS19910	COG0129	dihydroxy-acid dehydratase activity
HXS80_RS19915	COG0515	serine threonine protein kinase
HXS80_RS19915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXS80_RS19920	COG4991	sh3 domain protein
HXS80_RS19930	COG1129	ABC transporter
HXS80_RS19930	COG0842	Transport permease protein
HXS80_RS19940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXS80_RS19960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXS80_RS20020	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HXS80_RS20025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HXS80_RS20030	COG0181	hydroxymethylbilane synthase activity
HXS80_RS20035	COG1648	precorrin-2 dehydrogenase activity
HXS80_RS20035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXS80_RS20040	COG0113	porphobilinogen synthase activity
HXS80_RS20070	COG4974	Belongs to the 'phage' integrase family
HXS80_RS20100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HXS80_RS20170	COG1136	(ABC) transporter
HXS80_RS20170	COG0577	efflux transmembrane transporter activity
HXS80_RS20185	COG0745	RESPONSE REGULATOR receiver
HXS80_RS20190	COG2205	protein histidine kinase activity
HXS80_RS20210	COG1309	transcriptional regulator
HXS80_RS20305	COG1335	isochorismatase
HXS80_RS20320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HXS80_RS20350	COG2205	protein histidine kinase activity
HXS80_RS20355	COG0247	lactate metabolic process
HXS80_RS20355	COG0277	FAD linked oxidase domain protein
HXS80_RS20370	COG0583	DNA-binding transcription factor activity
HXS80_RS20375	COG5006	permease, DMT superfamily
HXS80_RS20380	COG4221	oxidoreductase activity
HXS80_RS20385	COG1309	transcriptional regulator
HXS80_RS20395	COG1051	belongs to the nudix hydrolase family
HXS80_RS20410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXS80_RS20630	COG0629	single-stranded DNA binding
HXS80_RS20720	COG1024	Enoyl-CoA hydratase
HXS80_RS20770	COG2252	PERMEase
HXS80_RS20795	COG1309	transcriptional regulator
HXS80_RS20820	COG0667	Aldo Keto reductase
HXS80_RS20835	COG0671	phosphoesterase, PA-phosphatase related
HXS80_RS20870	COG1309	transcriptional regulator
HXS80_RS20875	COG2084	Dehydrogenase
HXS80_RS20885	COG2267	carboxylic ester hydrolase activity
HXS80_RS20925	COG0515	serine threonine protein kinase
HXS80_RS20930	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS21000	COG0018	arginyl-trna synthetase
HXS80_RS21005	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HXS80_RS21025	COG1690	Belongs to the RtcB family
HXS80_RS21030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HXS80_RS21065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXS80_RS21070	COG0406	alpha-ribazole phosphatase activity
HXS80_RS21080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXS80_RS21085	COG0785	Cytochrome C biogenesis protein
HXS80_RS21090	COG1333	cytochrome c biogenesis protein
HXS80_RS21095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXS80_RS21105	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HXS80_RS21120	COG0163	prenyltransferase activity
HXS80_RS21130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HXS80_RS21140	COG1301	dicarboxylic acid transport
HXS80_RS21150	COG1309	transcriptional regulator
HXS80_RS21170	COG2770	Histidine kinase
HXS80_RS21170	COG2208	phosphoserine phosphatase activity
HXS80_RS21185	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS21190	COG0183	Belongs to the thiolase family
HXS80_RS21210	COG1196	nuclear chromosome segregation
HXS80_RS21210	COG0739	heme binding
HXS80_RS21210	COG0741	lytic transglycosylase activity
HXS80_RS21295	COG1051	belongs to the nudix hydrolase family
HXS80_RS21315	COG0768	penicillin binding
HXS80_RS21320	COG3386	PFAM SMP-30 Gluconolaconase
HXS80_RS21335	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HXS80_RS21430	COG1686	Belongs to the peptidase S11 family
HXS80_RS21470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXS80_RS21475	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS21485	COG2124	cytochrome p450
HXS80_RS21525	COG0667	Aldo Keto reductase
HXS80_RS21540	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS21560	COG1846	Transcriptional regulator
HXS80_RS21565	COG3384	dioxygenase
HXS80_RS21580	COG0477	Major facilitator Superfamily
HXS80_RS21600	COG0243	molybdopterin cofactor binding
HXS80_RS21605	COG0437	4 iron, 4 sulfur cluster binding
HXS80_RS21630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HXS80_RS21645	COG3263	regulation of cellular component size
HXS80_RS21655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HXS80_RS21660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HXS80_RS21670	COG0315	cyclic pyranopterin monophosphate synthase activity
HXS80_RS21675	COG0521	Mo-molybdopterin cofactor biosynthetic process
HXS80_RS21710	COG2340	Cysteine-rich secretory protein family
HXS80_RS21740	COG0708	Exodeoxyribonuclease III
HXS80_RS21750	COG2072	flavoprotein involved in K transport
HXS80_RS21760	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS21785	COG0793	Belongs to the peptidase S41A family
HXS80_RS21785	COG4946	Tricorn protease homolog
HXS80_RS21795	COG2409	Drug exporters of the RND superfamily
HXS80_RS21830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXS80_RS21835	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HXS80_RS21855	COG0442	prolyl-tRNA aminoacylation
HXS80_RS21860	COG2207	Transcriptional regulator
HXS80_RS21865	COG2223	nitrite transmembrane transporter activity
HXS80_RS21945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HXS80_RS21975	COG0084	hydrolase, TatD family'
HXS80_RS21980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HXS80_RS21985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HXS80_RS22000	COG4115	mRNA cleavage
HXS80_RS22020	COG0488	(ABC) transporter
HXS80_RS22045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXS80_RS22060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HXS80_RS22070	COG2197	response regulator
HXS80_RS22075	COG1846	Transcriptional regulator
HXS80_RS22080	COG4106	trans-aconitate 2-methyltransferase activity
HXS80_RS22105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HXS80_RS22110	COG0193	aminoacyl-tRNA hydrolase activity
HXS80_RS22115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HXS80_RS22120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HXS80_RS22125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HXS80_RS22135	COG4585	Histidine kinase
HXS80_RS22150	COG2226	methyltransferase
HXS80_RS22180	COG2124	cytochrome p450
HXS80_RS22225	COG0346	lactoylglutathione lyase activity
HXS80_RS22230	COG0477	Major facilitator Superfamily
HXS80_RS22235	COG1136	(ABC) transporter
HXS80_RS22240	COG1136	(ABC) transporter
HXS80_RS22240	COG0577	efflux transmembrane transporter activity
HXS80_RS22305	COG1473	amidohydrolase
HXS80_RS22375	COG1335	isochorismatase
HXS80_RS22395	COG0515	serine threonine protein kinase
HXS80_RS22395	COG2815	serine threonine protein kinase
HXS80_RS22415	COG1652	LysM domain
HXS80_RS22425	COG0148	phosphopyruvate hydratase activity
HXS80_RS22445	COG1252	NADH dehydrogenase
HXS80_RS22450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HXS80_RS22455	COG0577	efflux transmembrane transporter activity
HXS80_RS22455	COG1136	(ABC) transporter
HXS80_RS22460	COG0577	efflux transmembrane transporter activity
HXS80_RS22460	COG1136	(ABC) transporter
HXS80_RS22485	COG0183	Belongs to the thiolase family
HXS80_RS22490	COG2755	lipolytic protein G-D-S-L family
HXS80_RS22530	COG0531	amino acid
HXS80_RS22535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HXS80_RS22540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS22550	COG1228	amidohydrolase
HXS80_RS22555	COG1191	sigma factor activity
HXS80_RS22560	COG1366	Belongs to the anti-sigma-factor antagonist family
HXS80_RS22590	COG3104	oligopeptide transport
HXS80_RS22595	COG0745	RESPONSE REGULATOR receiver
HXS80_RS22600	COG2205	protein histidine kinase activity
HXS80_RS22630	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HXS80_RS22710	COG1316	TRANSCRIPTIONal
HXS80_RS22720	COG1316	TRANSCRIPTIONal
HXS80_RS22725	COG1316	TRANSCRIPTIONal
HXS80_RS22730	COG1316	TRANSCRIPTIONal
HXS80_RS22735	COG1316	TRANSCRIPTIONal
HXS80_RS22760	COG0778	Nitroreductase
HXS80_RS22760	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HXS80_RS22765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HXS80_RS22800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXS80_RS22805	COG2835	tetraacyldisaccharide 4'-kinase activity
HXS80_RS22825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HXS80_RS22865	COG0714	Associated with various cellular activities
HXS80_RS22885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HXS80_RS22890	COG0745	RESPONSE REGULATOR receiver
HXS80_RS22895	COG5000	phosphorelay sensor kinase activity
HXS80_RS22895	COG5002	protein histidine kinase activity
HXS80_RS22900	COG0823	Involved in the tonB-independent uptake of proteins
HXS80_RS22910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HXS80_RS22915	COG2197	response regulator
HXS80_RS22930	COG0653	protein targeting
HXS80_RS22950	COG2902	Dehydrogenase
HXS80_RS22955	COG1134	teichoic acid transport
HXS80_RS22965	COG1309	transcriptional regulator
HXS80_RS22975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HXS80_RS22980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HXS80_RS22985	COG2226	methyltransferase
HXS80_RS22985	COG1073	alpha beta
HXS80_RS22990	COG4122	O-methyltransferase activity
HXS80_RS22995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HXS80_RS23000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HXS80_RS23005	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS23010	COG1442	glycosyl transferase family 8
HXS80_RS23010	COG1216	Glycosyl transferase, family 2
HXS80_RS23015	COG0395	ABC-type sugar transport system, permease component
HXS80_RS23035	COG0515	serine threonine protein kinase
HXS80_RS23040	COG0515	serine threonine protein kinase
HXS80_RS23045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HXS80_RS23060	COG2884	Cell division ATP-binding protein ftsE
HXS80_RS23065	COG2177	Part of the ABC transporter FtsEX involved in
HXS80_RS23070	COG0793	Belongs to the peptidase S41A family
HXS80_RS23075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HXS80_RS23125	COG0583	DNA-binding transcription factor activity
HXS80_RS23130	COG2223	nitrite transmembrane transporter activity
HXS80_RS23155	COG3973	AAA domain
HXS80_RS23155	COG3973	AAA domain
HXS80_RS23165	COG0776	regulation of translation
HXS80_RS23170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXS80_RS23175	COG1678	Uncharacterized ACR, COG1678
HXS80_RS23185	COG2182	Extracellular solute-binding protein
HXS80_RS23190	COG1175	transmembrane transport
HXS80_RS23195	COG0395	ABC-type sugar transport system, permease component
HXS80_RS23200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS80_RS23250	COG3654	unkown
HXS80_RS23280	COG3480	Lon protease (S16) C-terminal proteolytic domain
HXS80_RS23300	COG1732	Glycine betaine
HXS80_RS23305	COG1174	glycine betaine transport
HXS80_RS23310	COG1125	glycine betaine transport
HXS80_RS23310	COG0517	IMP dehydrogenase activity
HXS80_RS23315	COG1174	glycine betaine transport
HXS80_RS23325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HXS80_RS23335	COG0277	FAD linked oxidase domain protein
HXS80_RS23370	COG1335	isochorismatase
HXS80_RS23380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HXS80_RS23390	COG1113	amino acid transport
HXS80_RS23405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS23430	COG1234	tRNA 3'-trailer cleavage
HXS80_RS23440	COG1263	PTS System
HXS80_RS23445	COG1263	PTS System
HXS80_RS23450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXS80_RS23455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HXS80_RS23465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HXS80_RS23485	COG0477	Major facilitator Superfamily
HXS80_RS23510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXS80_RS23525	COG4555	ABC transporter
HXS80_RS23540	COG2733	membrane
HXS80_RS23550	COG0596	Alpha beta hydrolase
HXS80_RS23555	COG2175	clavaminate synthase activity
HXS80_RS23570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXS80_RS23575	COG3135	benzoate transporter
HXS80_RS23625	COG1074	ATP-dependent DNA helicase activity
HXS80_RS23655	COG0270	DNA (cytosine-5-)-methyltransferase activity
HXS80_RS23685	COG3764	Sortase (surface protein transpeptidase)
HXS80_RS23695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXS80_RS23705	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
HXS80_RS23705	COG0706	membrane insertase activity
HXS80_RS23710	COG0179	Fumarylacetoacetate (FAA) hydrolase
HXS80_RS23715	COG4702	Belongs to the UPF0303 family
HXS80_RS23720	COG0673	inositol 2-dehydrogenase activity
HXS80_RS23725	COG1940	carbohydrate kinase activity
HXS80_RS23735	COG2188	Transcriptional regulator
HXS80_RS23740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXS80_RS23805	COG3397	chitin binding
HXS80_RS23815	COG1414	Transcriptional regulator
HXS80_RS23820	COG1126	abc transporter atp-binding protein
HXS80_RS23825	COG0765	amino acid transport
HXS80_RS23830	COG0765	amino acid transport
HXS80_RS23835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXS80_RS23845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXS80_RS23855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS23930	COG0745	RESPONSE REGULATOR receiver
HXS80_RS23945	COG2985	domain, Protein
HXS80_RS23960	COG0395	ABC-type sugar transport system, permease component
HXS80_RS23995	COG4977	sequence-specific DNA binding
HXS80_RS24005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXS80_RS24030	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HXS80_RS24055	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS24070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXS80_RS24075	COG1309	transcriptional regulator
HXS80_RS24095	COG1946	Acyl-CoA thioesterase
HXS80_RS24120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXS80_RS24135	COG4106	trans-aconitate 2-methyltransferase activity
HXS80_RS24170	COG0028	Belongs to the TPP enzyme family
HXS80_RS24200	COG0477	Major facilitator Superfamily
HXS80_RS24215	COG1472	Belongs to the glycosyl hydrolase 3 family
HXS80_RS24240	COG1404	Belongs to the peptidase S8 family
HXS80_RS24310	COG1609	Transcriptional regulator
HXS80_RS24315	COG0673	inositol 2-dehydrogenase activity
HXS80_RS24350	COG0596	Alpha beta hydrolase
HXS80_RS24360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HXS80_RS24385	COG2409	Drug exporters of the RND superfamily
HXS80_RS24400	COG2318	DinB family
HXS80_RS24410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXS80_RS24420	COG3718	enzyme involved in inositol metabolism
HXS80_RS24425	COG3962	Belongs to the TPP enzyme family
HXS80_RS24440	COG4585	Histidine kinase
HXS80_RS24540	COG1674	ftsk spoiiie
HXS80_RS24575	COG0629	single-stranded DNA binding
HXS80_RS24600	COG1136	(ABC) transporter
HXS80_RS24600	COG0577	efflux transmembrane transporter activity
HXS80_RS24620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HXS80_RS24650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXS80_RS24665	COG1486	melibiose metabolic process
HXS80_RS24670	COG0395	ABC-type sugar transport system, permease component
HXS80_RS24675	COG1175	transmembrane transport
HXS80_RS24700	COG0668	transmembrane transport
HXS80_RS24710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS80_RS24710	COG3291	Pkd domain containing protein
HXS80_RS24730	COG0583	DNA-binding transcription factor activity
HXS80_RS24735	COG4266	Belongs to the allantoicase family
HXS80_RS24780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HXS80_RS24790	COG2252	PERMEase
HXS80_RS24805	COG1404	Belongs to the peptidase S8 family
HXS80_RS24810	COG0110	maltose O-acetyltransferase activity
HXS80_RS24825	COG0640	Transcriptional regulator
HXS80_RS24830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HXS80_RS24840	COG0783	Belongs to the Dps family
HXS80_RS24845	COG0584	glycerophosphoryl diester phosphodiesterase
HXS80_RS24850	COG1113	amino acid transport
HXS80_RS24855	COG1113	amino acid transport
HXS80_RS24860	COG1268	BioY protein
HXS80_RS24870	COG1113	amino acid transport
HXS80_RS24890	COG0475	glutathione-regulated potassium exporter activity
HXS80_RS24900	COG3594	Acyltransferase
HXS80_RS24920	COG0544	peptidyl-prolyl cis-trans isomerase activity
HXS80_RS24925	COG0740	serine-type endopeptidase activity
HXS80_RS24930	COG0740	serine-type endopeptidase activity
HXS80_RS24935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HXS80_RS24950	COG0285	dihydrofolate synthase activity
HXS80_RS24960	COG0105	UTP biosynthetic process
HXS80_RS24965	COG1077	Cell shape determining protein MreB Mrl
HXS80_RS24980	COG0768	penicillin binding
HXS80_RS24985	COG0772	Belongs to the SEDS family
HXS80_RS25010	COG1530	ribonuclease E activity
HXS80_RS25015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HXS80_RS25020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HXS80_RS25025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HXS80_RS25050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HXS80_RS25060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HXS80_RS25075	COG0501	Belongs to the peptidase M48B family
HXS80_RS25090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HXS80_RS25105	COG0588	phosphoglycerate mutase activity
HXS80_RS25125	COG0495	leucyl-tRNA aminoacylation
HXS80_RS25135	COG1307	EDD domain protein, DegV family
HXS80_RS25140	COG1555	photosystem II stabilization
HXS80_RS25170	COG0268	Binds directly to 16S ribosomal RNA
HXS80_RS25175	COG0481	GTPase activity
HXS80_RS25180	COG1022	Amp-dependent synthetase and ligase
HXS80_RS25215	COG1420	regulation of RNA biosynthetic process
HXS80_RS25220	COG0484	heat shock protein binding
HXS80_RS25235	COG0537	adenosine 5'-monophosphoramidase activity
HXS80_RS25240	COG1234	tRNA 3'-trailer cleavage
HXS80_RS25245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXS80_RS25255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HXS80_RS25255	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HXS80_RS25265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HXS80_RS25275	COG2315	Protein conserved in bacteria
HXS80_RS25300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HXS80_RS25315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXS80_RS25325	COG1381	Involved in DNA repair and RecF pathway recombination
HXS80_RS25330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXS80_RS25340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXS80_RS25345	COG1121	(ABC) transporter
HXS80_RS25355	COG0423	glycine-tRNA ligase activity
HXS80_RS25365	COG3104	oligopeptide transport
HXS80_RS25380	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS25385	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS25395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS25400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS25405	COG0662	Cupin 2, conserved barrel domain protein
HXS80_RS25415	COG0367	asparagine synthase
HXS80_RS25440	COG2345	Transcriptional regulator
HXS80_RS25445	COG0477	Major facilitator Superfamily
HXS80_RS25480	COG2124	cytochrome p450
HXS80_RS25485	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS25490	COG0277	FAD linked oxidase domain protein
HXS80_RS25505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXS80_RS25575	COG3226	Transcriptional regulator
HXS80_RS25580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXS80_RS25620	COG1309	transcriptional regulator
HXS80_RS25635	COG1309	transcriptional regulator
HXS80_RS25645	COG2066	Belongs to the glutaminase family
HXS80_RS25650	COG0477	Major facilitator Superfamily
HXS80_RS25680	COG2188	Transcriptional regulator
HXS80_RS25700	COG3842	ATPase activity
HXS80_RS25705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXS80_RS25710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXS80_RS25710	COG0574	Belongs to the PEP-utilizing enzyme family
HXS80_RS25735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXS80_RS25735	COG2146	nitrite reductase [NAD(P)H] activity
HXS80_RS25780	COG2949	membrane
HXS80_RS25790	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HXS80_RS25800	COG0358	DNA primase activity
HXS80_RS25805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXS80_RS25820	COG1070	Carbohydrate kinase
HXS80_RS25855	COG0477	Major facilitator Superfamily
HXS80_RS25860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HXS80_RS25860	COG0825	malonyl-CoA metabolic process
HXS80_RS25865	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS25875	COG1522	sequence-specific DNA binding
HXS80_RS25910	COG2130	NADP-dependent
HXS80_RS25915	COG1764	response to oxidative stress
HXS80_RS25940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS25945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXS80_RS25950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXS80_RS26000	COG1741	Belongs to the pirin family
HXS80_RS26060	COG1404	Belongs to the peptidase S8 family
HXS80_RS26065	COG1674	ftsk spoiiie
HXS80_RS26140	COG1929	Belongs to the glycerate kinase type-1 family
HXS80_RS26150	COG0745	RESPONSE REGULATOR receiver
HXS80_RS26155	COG2205	protein histidine kinase activity
HXS80_RS26165	COG0789	Transcriptional regulator
HXS80_RS26170	COG0667	Aldo Keto reductase
HXS80_RS26185	COG2197	response regulator
HXS80_RS26190	COG4585	Histidine kinase
HXS80_RS26205	COG1309	transcriptional regulator
HXS80_RS26210	COG0477	Major facilitator Superfamily
HXS80_RS26220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HXS80_RS26265	COG1358	cellular component organization or biogenesis
HXS80_RS26365	COG2259	Doxx family
HXS80_RS26410	COG2124	cytochrome p450
HXS80_RS26415	COG0183	Belongs to the thiolase family
HXS80_RS26425	COG3845	ABC transporter
HXS80_RS26475	COG1309	transcriptional regulator
HXS80_RS26480	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS26505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS26525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS26530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HXS80_RS26545	COG3340	Belongs to the peptidase S51 family
HXS80_RS26555	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS26560	COG0183	Belongs to the thiolase family
HXS80_RS26565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HXS80_RS26575	COG2030	dehydratase
HXS80_RS26585	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS26600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXS80_RS26605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HXS80_RS26620	COG0800	Aldolase
HXS80_RS26625	COG3022	response to hydroperoxide
HXS80_RS26675	COG0384	phenazine biosynthesis protein PhzF
HXS80_RS26685	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS26690	COG3540	Alkaline phosphatase
HXS80_RS26700	COG2814	Major facilitator Superfamily
HXS80_RS26715	COG1834	amidinotransferase
HXS80_RS26735	COG1120	ATPase activity
HXS80_RS26740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS26800	COG1994	Peptidase M50
HXS80_RS26820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HXS80_RS26825	COG0477	Major facilitator Superfamily
HXS80_RS26840	COG2814	Major facilitator Superfamily
HXS80_RS26845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HXS80_RS26845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXS80_RS26850	COG2132	Multicopper oxidase
HXS80_RS26865	COG0174	glutamine synthetase
HXS80_RS26890	COG0494	nUDIX hydrolase
HXS80_RS26945	COG0477	Major facilitator Superfamily
HXS80_RS26950	COG2890	protein-(glutamine-N5) methyltransferase activity
HXS80_RS26965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HXS80_RS26990	COG1609	Transcriptional regulator
HXS80_RS26995	COG2182	Extracellular solute-binding protein
HXS80_RS27005	COG0395	ABC-type sugar transport system, permease component
HXS80_RS27010	COG0366	Alpha amylase catalytic
HXS80_RS27070	COG2197	response regulator
HXS80_RS27080	COG2409	Drug exporters of the RND superfamily
HXS80_RS27085	COG0745	RESPONSE REGULATOR receiver
HXS80_RS27105	COG0673	inositol 2-dehydrogenase activity
HXS80_RS27110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXS80_RS27135	COG3896	Chloramphenicol phosphotransferase-like protein
HXS80_RS27140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXS80_RS27165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HXS80_RS27170	COG0321	lipoyl(octanoyl) transferase activity
HXS80_RS27185	COG1090	epimerase
HXS80_RS27205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HXS80_RS27215	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXS80_RS27220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXS80_RS27225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HXS80_RS27230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HXS80_RS27245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HXS80_RS27260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS80_RS27285	COG4585	Histidine kinase
HXS80_RS27290	COG2197	response regulator
HXS80_RS27295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXS80_RS27305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HXS80_RS27325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXS80_RS27335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HXS80_RS27340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HXS80_RS27350	COG1376	ErfK ybiS ycfS ynhG family protein
HXS80_RS27360	COG1845	cytochrome c oxidase, subunit III
HXS80_RS27365	COG2010	Cytochrome c
HXS80_RS27370	COG0723	plastoquinol--plastocyanin reductase activity
HXS80_RS27375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HXS80_RS27380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HXS80_RS27385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXS80_RS27450	COG0003	Pfam Anion-transporting ATPase
HXS80_RS27460	COG1940	carbohydrate kinase activity
HXS80_RS27490	COG2197	response regulator
HXS80_RS27495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXS80_RS27510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HXS80_RS27520	COG2193	ferroxidase activity
HXS80_RS27525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HXS80_RS27530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HXS80_RS27535	COG2815	serine threonine protein kinase
HXS80_RS27535	COG0515	serine threonine protein kinase
HXS80_RS27540	COG2022	thiamine diphosphate biosynthetic process
HXS80_RS27550	COG2022	thiamine diphosphate biosynthetic process
HXS80_RS27550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXS80_RS27570	COG0352	thiamine-phosphate diphosphorylase activity
HXS80_RS27585	COG1233	COG1233 Phytoene dehydrogenase and related
HXS80_RS27605	COG1129	ABC transporter
HXS80_RS27615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HXS80_RS27635	COG0714	Associated with various cellular activities
HXS80_RS27645	COG0275	rRNA processing
HXS80_RS27655	COG0768	penicillin binding
HXS80_RS27660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HXS80_RS27670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HXS80_RS27675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HXS80_RS27685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXS80_RS27705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HXS80_RS27710	COG1799	cell septum assembly
HXS80_RS27720	COG3599	regulation of cell shape
HXS80_RS27725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HXS80_RS27735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HXS80_RS27780	COG0587	DNA-directed DNA polymerase activity
HXS80_RS27790	COG1432	Conserved Protein
HXS80_RS27810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HXS80_RS27830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HXS80_RS27835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXS80_RS27840	COG0131	Imidazoleglycerol-phosphate dehydratase
HXS80_RS27850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HXS80_RS27855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HXS80_RS27860	COG0251	oxidation-reduction process
HXS80_RS27865	COG0107	imidazoleglycerol-phosphate synthase activity
HXS80_RS27885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HXS80_RS27890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HXS80_RS27910	COG0134	indole-3-glycerol-phosphate synthase activity
HXS80_RS27920	COG0133	tryptophan synthase activity
HXS80_RS27925	COG0159	tryptophan synthase activity
HXS80_RS27935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HXS80_RS27945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HXS80_RS27950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXS80_RS27980	COG0069	glutamate synthase activity
HXS80_RS27980	COG0067	glutamate synthase
HXS80_RS27980	COG0070	glutamate synthase
HXS80_RS27990	COG0705	Rhomboid family
HXS80_RS28020	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS28025	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS28030	COG1309	transcriptional regulator
HXS80_RS28035	COG0183	Belongs to the thiolase family
HXS80_RS28040	COG1278	Cold shock
HXS80_RS28065	COG1024	Enoyl-CoA hydratase
HXS80_RS28070	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS28105	COG0287	Prephenate dehydrogenase
HXS80_RS28105	COG1605	Chorismate mutase
HXS80_RS28140	COG0737	Belongs to the 5'-nucleotidase family
HXS80_RS28185	COG0559	Belongs to the binding-protein-dependent transport system permease family
HXS80_RS28195	COG2050	protein possibly involved in aromatic compounds catabolism
HXS80_RS28230	COG1643	Atp-dependent helicase
HXS80_RS28235	COG2226	methyltransferase
HXS80_RS28255	COG0237	dephospho-CoA kinase activity
HXS80_RS28270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HXS80_RS28280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXS80_RS28305	COG0436	Aminotransferase
HXS80_RS28320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXS80_RS28325	COG2313	pseudouridylate synthase activity
HXS80_RS28335	COG2814	Major facilitator Superfamily
HXS80_RS28345	COG0584	glycerophosphoryl diester phosphodiesterase
HXS80_RS28355	COG0556	nucleotide-excision repair
HXS80_RS28385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXS80_RS28410	COG0322	excinuclease ABC activity
HXS80_RS28415	COG1660	Displays ATPase and GTPase activities
HXS80_RS28420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HXS80_RS28425	COG1481	regulation of sporulation
HXS80_RS28430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HXS80_RS28435	COG0126	phosphoglycerate kinase activity
HXS80_RS28440	COG0149	triose-phosphate isomerase activity
HXS80_RS28445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HXS80_RS28455	COG0166	Belongs to the GPI family
HXS80_RS28475	COG0363	glucosamine-6-phosphate deaminase activity
HXS80_RS28490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HXS80_RS28500	COG0109	protoheme IX farnesyltransferase activity
HXS80_RS28535	COG0719	Fe-S assembly protein
HXS80_RS28545	COG0396	ATPase activity
HXS80_RS28550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXS80_RS28555	COG0822	iron-sulfur transferase activity
HXS80_RS28560	COG2151	metal-sulfur cluster biosynthetic enzyme
HXS80_RS28575	COG3226	Transcriptional regulator
HXS80_RS28590	COG2171	N-acyltransferase activity
HXS80_RS28595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXS80_RS28630	COG0768	penicillin binding
HXS80_RS28635	COG2197	response regulator
HXS80_RS28640	COG4585	Histidine kinase
HXS80_RS28680	COG1902	pentaerythritol trinitrate reductase activity
HXS80_RS28710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HXS80_RS28735	COG1797	cobyrinic acid a,c-diamide synthase activity
HXS80_RS28750	COG1492	cobalamin metabolic process
HXS80_RS28755	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HXS80_RS28770	COG0235	Class ii aldolase
HXS80_RS28795	COG0488	(ABC) transporter
HXS80_RS28805	COG1024	Enoyl-CoA hydratase
HXS80_RS28845	COG3387	PFAM Glycoside hydrolase 15-related
HXS80_RS28875	COG1404	Belongs to the peptidase S8 family
HXS80_RS28885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXS80_RS28890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HXS80_RS28905	COG2261	transglycosylase associated protein
HXS80_RS28910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXS80_RS28935	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS28940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HXS80_RS28970	COG3830	Belongs to the UPF0237 family
HXS80_RS28970	COG0560	Phosphoserine phosphatase
HXS80_RS28975	COG1716	ATPase activity
HXS80_RS28975	COG1131	(ABC) transporter
HXS80_RS28975	COG0842	Transport permease protein
HXS80_RS28985	COG4585	Histidine kinase
HXS80_RS28990	COG2197	response regulator
HXS80_RS29000	COG1119	ATPase activity
HXS80_RS29025	COG1881	PFAM PEBP family protein
HXS80_RS29035	COG2094	Belongs to the DNA glycosylase MPG family
HXS80_RS29040	COG2094	Belongs to the DNA glycosylase MPG family
HXS80_RS29160	COG3845	ABC transporter
HXS80_RS29180	COG0148	phosphopyruvate hydratase activity
HXS80_RS29190	COG2382	esterase
HXS80_RS29195	COG1132	(ABC) transporter
HXS80_RS29205	COG1132	(ABC) transporter
HXS80_RS29210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HXS80_RS29215	COG1120	ATPase activity
HXS80_RS29220	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS29225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS29230	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HXS80_RS29240	COG3559	Exporter of polyketide antibiotics
HXS80_RS29245	COG1131	(ABC) transporter
HXS80_RS29255	COG0587	DNA-directed DNA polymerase activity
HXS80_RS29335	COG1295	ribonuclease BN
HXS80_RS29410	COG4221	oxidoreductase activity
HXS80_RS29425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS29460	COG2376	Dihydroxyacetone kinase
HXS80_RS29465	COG1461	Dihydroxyacetone kinase
HXS80_RS29480	COG0488	(ABC) transporter
HXS80_RS29510	COG1191	sigma factor activity
HXS80_RS29515	COG1309	transcriptional regulator
HXS80_RS29520	COG3246	L-lysine catabolic process to acetate
HXS80_RS29525	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXS80_RS29540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HXS80_RS29545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HXS80_RS29575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS80_RS29660	COG1120	ATPase activity
HXS80_RS29665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS29670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS29680	COG0789	Transcriptional regulator
HXS80_RS29705	COG1874	Beta-galactosidase
HXS80_RS29705	COG0366	Alpha amylase catalytic
HXS80_RS29710	COG1609	Transcriptional regulator
HXS80_RS29715	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXS80_RS29725	COG1129	ABC transporter
HXS80_RS29730	COG1879	ABC-type sugar transport system periplasmic component
HXS80_RS29780	COG0328	RNA-DNA hybrid ribonuclease activity
HXS80_RS29785	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS29790	COG1132	(ABC) transporter
HXS80_RS29815	COG4753	response regulator
HXS80_RS29815	COG2207	Transcriptional regulator
HXS80_RS29820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS29825	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS29830	COG1120	ATPase activity
HXS80_RS29840	COG2274	protein secretion by the type I secretion system
HXS80_RS29845	COG1132	(ABC) transporter
HXS80_RS29965	COG5002	protein histidine kinase activity
HXS80_RS30000	COG0464	growth
HXS80_RS30010	COG1349	DNA-binding transcription factor activity
HXS80_RS30025	COG0702	epimerase
HXS80_RS30050	COG1940	carbohydrate kinase activity
HXS80_RS30055	COG2223	nitrite transmembrane transporter activity
HXS80_RS30075	COG0445	tRNA wobble uridine modification
HXS80_RS30080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS30090	COG0494	nUDIX hydrolase
HXS80_RS30120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HXS80_RS30170	COG0584	glycerophosphoryl diester phosphodiesterase
HXS80_RS30190	COG0671	phosphoesterase, PA-phosphatase related
HXS80_RS30235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HXS80_RS30250	COG2706	6-phosphogluconolactonase activity
HXS80_RS30280	COG2124	cytochrome p450
HXS80_RS30295	COG0477	Major facilitator Superfamily
HXS80_RS30315	COG2267	carboxylic ester hydrolase activity
HXS80_RS30325	COG3971	2-oxopent-4-enoate hydratase activity
HXS80_RS30330	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HXS80_RS30335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXS80_RS30355	COG0515	serine threonine protein kinase
HXS80_RS30355	COG2815	serine threonine protein kinase
HXS80_RS30360	COG0667	Aldo Keto reductase
HXS80_RS30385	COG1253	flavin adenine dinucleotide binding
HXS80_RS30420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HXS80_RS30440	COG0174	glutamine synthetase
HXS80_RS30445	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS30480	COG4981	capsule polysaccharide biosynthetic process
HXS80_RS30500	COG2835	tetraacyldisaccharide 4'-kinase activity
HXS80_RS30510	COG0402	S-adenosylhomocysteine deaminase activity
HXS80_RS30525	COG0243	molybdopterin cofactor binding
HXS80_RS30530	COG0542	response to heat
HXS80_RS30585	COG1335	isochorismatase
HXS80_RS30600	COG2890	protein-(glutamine-N5) methyltransferase activity
HXS80_RS30610	COG4912	Dna alkylation repair
HXS80_RS30630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HXS80_RS30635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HXS80_RS30640	COG2080	2 iron, 2 sulfur cluster binding
HXS80_RS30670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HXS80_RS30680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS30685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS80_RS30735	COG1891	lyase activity
HXS80_RS30750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HXS80_RS30800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HXS80_RS30825	COG1309	transcriptional regulator
HXS80_RS30830	COG1982	Orn Lys Arg decarboxylase major
HXS80_RS30835	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS30855	COG0154	amidase activity
HXS80_RS30890	COG0531	amino acid
HXS80_RS30900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS30920	COG0443	Heat shock 70 kDa protein
HXS80_RS30970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HXS80_RS30975	COG1116	anion transmembrane transporter activity
HXS80_RS30985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS30995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HXS80_RS31005	COG1132	(ABC) transporter
HXS80_RS31010	COG1846	Transcriptional regulator
HXS80_RS31015	COG0277	FAD linked oxidase domain protein
HXS80_RS31020	COG0673	inositol 2-dehydrogenase activity
HXS80_RS31030	COG1132	(ABC) transporter
HXS80_RS31050	COG1793	dna ligase
HXS80_RS31065	COG1946	Acyl-CoA thioesterase
HXS80_RS31080	COG0386	Belongs to the glutathione peroxidase family
HXS80_RS31085	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS31095	COG0242	peptide deformylase activity
HXS80_RS31105	COG3442	glutamine amidotransferase
HXS80_RS31110	COG0205	6-phosphofructokinase activity
HXS80_RS31125	COG0204	Acyl-transferase
HXS80_RS31155	COG0829	nickel cation binding
HXS80_RS31160	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HXS80_RS31170	COG0804	urea catabolic process
HXS80_RS31175	COG0832	Belongs to the urease beta subunit family
HXS80_RS31180	COG0831	urea catabolic process
HXS80_RS31190	COG0740	serine-type endopeptidase activity
HXS80_RS31205	COG1280	lysine exporter protein (LysE YggA)
HXS80_RS31210	COG0583	DNA-binding transcription factor activity
HXS80_RS31230	COG0156	8-amino-7-oxononanoate synthase activity
HXS80_RS31235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HXS80_RS31240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HXS80_RS31245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HXS80_RS31290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HXS80_RS31300	COG1940	carbohydrate kinase activity
HXS80_RS31305	COG2188	Transcriptional regulator
HXS80_RS31310	COG1595	DNA-templated transcription, initiation
HXS80_RS31325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXS80_RS31350	COG0626	cystathionine gamma-synthase activity
HXS80_RS31370	COG0419	ATPase involved in DNA repair
HXS80_RS31375	COG0420	3'-5' exonuclease activity
HXS80_RS31380	COG1739	Uncharacterized protein family UPF0029
HXS80_RS31385	COG1832	CoA-binding protein
HXS80_RS31425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXS80_RS31445	COG1968	undecaprenyl-diphosphatase activity
HXS80_RS31460	COG0243	molybdopterin cofactor binding
HXS80_RS31465	COG2226	methyltransferase
HXS80_RS31535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HXS80_RS31595	COG0069	glutamate synthase activity
HXS80_RS31610	COG0784	Response regulator, receiver
HXS80_RS31615	COG4251	negative regulation of phosphorylation
HXS80_RS31620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXS80_RS31625	COG4249	Peptidase C14 caspase catalytic subunit p20
HXS80_RS31625	COG2319	Wd-40 repeat
HXS80_RS31655	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HXS80_RS31665	COG1215	transferase activity, transferring glycosyl groups
HXS80_RS31810	COG0384	phenazine biosynthesis protein PhzF
HXS80_RS31840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXS80_RS31840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXS80_RS31850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXS80_RS31870	COG1716	ATPase activity
HXS80_RS31890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HXS80_RS31920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXS80_RS31930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXS80_RS31945	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HXS80_RS31975	COG2018	Roadblock/LC7 domain
HXS80_RS32035	COG2364	Membrane
HXS80_RS32045	COG2270	Major facilitator Superfamily
HXS80_RS32060	COG1216	Glycosyl transferase, family 2
HXS80_RS32090	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS32095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HXS80_RS32135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HXS80_RS32140	COG0140	phosphoribosyl-ATP diphosphatase activity
HXS80_RS32145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HXS80_RS32150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXS80_RS32150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXS80_RS32155	COG3201	nicotinamide mononucleotide transporter
HXS80_RS32180	COG0738	Major facilitator superfamily
HXS80_RS32185	COG2233	PERMEase
HXS80_RS32215	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HXS80_RS32250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXS80_RS32260	COG1012	belongs to the aldehyde dehydrogenase family
HXS80_RS32275	COG2390	Transcriptional regulator
HXS80_RS32280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HXS80_RS32290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HXS80_RS32305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HXS80_RS32315	COG1758	RNA polymerase activity
HXS80_RS32330	COG0284	orotidine-5'-phosphate decarboxylase activity
HXS80_RS32335	COG0167	dihydroorotate dehydrogenase activity
HXS80_RS32340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXS80_RS32345	COG0505	Belongs to the CarA family
HXS80_RS32355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXS80_RS32360	COG0540	Belongs to the ATCase OTCase family
HXS80_RS32365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HXS80_RS32375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXS80_RS32380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HXS80_RS32385	COG0006	proline dipeptidase activity
HXS80_RS32395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HXS80_RS32400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXS80_RS32405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HXS80_RS32410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HXS80_RS32420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HXS80_RS32425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXS80_RS32445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HXS80_RS32465	COG0124	histidyl-tRNA synthetase
HXS80_RS32480	COG1196	nuclear chromosome segregation
HXS80_RS32495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HXS80_RS32500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXS80_RS32505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXS80_RS32515	COG2255	four-way junction helicase activity
HXS80_RS32520	COG0632	four-way junction helicase activity
HXS80_RS32530	COG0217	transcriptional regulatory protein
HXS80_RS32535	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HXS80_RS32540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HXS80_RS32550	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS32555	COG1560	Kdo2-lipid A biosynthetic process
HXS80_RS32560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HXS80_RS32580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HXS80_RS32595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXS80_RS32645	COG0456	acetyltransferase
HXS80_RS32655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HXS80_RS32710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXS80_RS32710	COG1648	precorrin-2 dehydrogenase activity
HXS80_RS32730	COG1464	Belongs to the NlpA lipoprotein family
HXS80_RS32735	COG2011	ABC-type metal ion transport system permease component
HXS80_RS32775	COG0477	Major facilitator Superfamily
HXS80_RS32795	COG0165	Argininosuccinate lyase
HXS80_RS32800	COG0137	argininosuccinate synthase activity
HXS80_RS32815	COG1438	arginine binding
HXS80_RS32820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXS80_RS32825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXS80_RS32830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HXS80_RS32835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HXS80_RS32895	COG0697	spore germination
HXS80_RS32905	COG1649	PFAM Uncharacterised BCR, COG1649
HXS80_RS32930	COG0072	phenylalanine-tRNA ligase activity
HXS80_RS32930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXS80_RS32935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HXS80_RS32945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXS80_RS32950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HXS80_RS32955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HXS80_RS32960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HXS80_RS32970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HXS80_RS33030	COG0517	IMP dehydrogenase activity
HXS80_RS33030	COG4175	Glycine betaine
HXS80_RS33035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXS80_RS33065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HXS80_RS33070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HXS80_RS33110	COG0805	protein transport
HXS80_RS33115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXS80_RS33135	COG2378	regulation of single-species biofilm formation
HXS80_RS33145	COG0545	Peptidyl-prolyl cis-trans isomerase
HXS80_RS33150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HXS80_RS33160	COG1609	Transcriptional regulator
HXS80_RS33165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HXS80_RS33170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HXS80_RS33180	COG4122	O-methyltransferase activity
HXS80_RS33185	COG1222	aaa ATPase
HXS80_RS33205	COG0517	IMP dehydrogenase activity
HXS80_RS33205	COG1994	Peptidase M50
HXS80_RS33215	COG2197	response regulator
HXS80_RS33220	COG4166	transmembrane transport
HXS80_RS33225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXS80_RS33230	COG0646	methionine synthase
HXS80_RS33230	COG1410	methionine synthase
HXS80_RS33235	COG1414	Transcriptional regulator
HXS80_RS33240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HXS80_RS33245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HXS80_RS33250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HXS80_RS33255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS33265	COG0215	cysteine-tRNA ligase activity
HXS80_RS33285	COG0598	Magnesium transport protein CorA
HXS80_RS33295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS33300	COG0667	Aldo Keto reductase
HXS80_RS33330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS80_RS33340	COG0564	pseudouridine synthase activity
HXS80_RS33355	COG2186	Transcriptional regulator
HXS80_RS33360	COG3265	gluconokinase activity
HXS80_RS33385	COG3573	Dehydrogenase
HXS80_RS33390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HXS80_RS33395	COG2149	membrane
HXS80_RS33415	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS33420	COG4935	Belongs to the peptidase S8 family
HXS80_RS33420	COG2234	aminopeptidase activity
HXS80_RS33430	COG0318	PFAM AMP-dependent synthetase and ligase
HXS80_RS33435	COG1028	Short-chain dehydrogenase reductase Sdr
HXS80_RS33440	COG3876	Protein conserved in bacteria
HXS80_RS33475	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS33500	COG2318	DinB family
HXS80_RS33510	COG2851	Citrate transporter
HXS80_RS33515	COG1309	transcriptional regulator
HXS80_RS33535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HXS80_RS33540	COG2188	Transcriptional regulator
HXS80_RS33550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HXS80_RS33560	COG2755	lipolytic protein G-D-S-L family
HXS80_RS33570	COG1725	Transcriptional regulator
HXS80_RS33585	COG0346	lactoylglutathione lyase activity
HXS80_RS33605	COG4565	transcriptional regulatory protein
HXS80_RS33660	COG0641	radical SAM
HXS80_RS33695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS33700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXS80_RS33710	COG1126	abc transporter atp-binding protein
HXS80_RS33730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXS80_RS33745	COG1799	cell septum assembly
HXS80_RS33750	COG1960	acyl-CoA dehydrogenase activity
HXS80_RS33755	COG0477	Major facilitator Superfamily
HXS80_RS33760	COG0671	phosphoesterase, PA-phosphatase related
HXS80_RS33775	COG0438	transferase activity, transferring glycosyl groups
HXS80_RS33790	COG1160	GTP binding
HXS80_RS33800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HXS80_RS33825	COG0494	nUDIX hydrolase
HXS80_RS33840	COG1187	pseudouridine synthase activity
HXS80_RS33845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HXS80_RS33850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HXS80_RS33865	COG0686	Belongs to the AlaDH PNT family
HXS80_RS33875	COG0494	nUDIX hydrolase
HXS80_RS33880	COG0504	CTP synthase activity
HXS80_RS33885	COG3387	PFAM Glycoside hydrolase 15-related
HXS80_RS33915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP