locus-tag	class	description
C4J65_RS00035	COG0248	Ppx GppA phosphatase
C4J65_RS00050	COG2890	protein-(glutamine-N5) methyltransferase activity
C4J65_RS00080	COG3250	beta-galactosidase activity
C4J65_RS00095	COG0667	Aldo Keto reductase
C4J65_RS00130	COG2124	cytochrome p450
C4J65_RS00145	COG0435	Glutathione S-transferase
C4J65_RS00170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4J65_RS00185	COG1007	ATP synthesis coupled electron transport
C4J65_RS00190	COG1006	Multisubunit Na H antiporter MnhC subunit
C4J65_RS00235	COG1796	DNA polymerase
C4J65_RS00235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4J65_RS00280	COG2706	6-phosphogluconolactonase activity
C4J65_RS00290	COG1309	transcriptional regulator
C4J65_RS00300	COG1357	PFAM Pentapeptide repeats (8 copies)
C4J65_RS00305	COG1595	DNA-templated transcription, initiation
C4J65_RS00320	COG1609	Transcriptional regulator
C4J65_RS00330	COG1879	ABC-type sugar transport system periplasmic component
C4J65_RS00345	COG1129	ABC transporter
C4J65_RS00350	COG4952	isomerase
C4J65_RS00355	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS00355	COG3347	Dehydrogenase
C4J65_RS00360	COG1070	Carbohydrate kinase
C4J65_RS00365	COG0247	lactate metabolic process
C4J65_RS00370	COG1139	Iron-sulfur cluster binding protein
C4J65_RS00375	COG1556	Lactate utilization protein
C4J65_RS00380	COG1136	(ABC) transporter
C4J65_RS00380	COG0577	efflux transmembrane transporter activity
C4J65_RS00420	COG3540	Alkaline phosphatase
C4J65_RS00455	COG0500	methyltransferase
C4J65_RS00460	COG0668	transmembrane transport
C4J65_RS00475	COG2409	Drug exporters of the RND superfamily
C4J65_RS00480	COG1846	Transcriptional regulator
C4J65_RS00525	COG1070	Carbohydrate kinase
C4J65_RS00540	COG1175	transmembrane transport
C4J65_RS00545	COG0395	ABC-type sugar transport system, permease component
C4J65_RS00550	COG1609	Transcriptional regulator
C4J65_RS00570	COG0800	Aldolase
C4J65_RS00595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J65_RS00605	COG1733	regulation of RNA biosynthetic process
C4J65_RS00620	COG3547	Transposase (IS116 IS110 IS902 family)
C4J65_RS00635	COG0298	carbon dioxide binding
C4J65_RS00645	COG0309	Hydrogenase expression formation protein (HypE)
C4J65_RS00690	COG2326	polyphosphate kinase activity
C4J65_RS00745	COG0617	tRNA 3'-terminal CCA addition
C4J65_RS00745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4J65_RS00745	COG0517	IMP dehydrogenase activity
C4J65_RS00790	COG0574	Belongs to the PEP-utilizing enzyme family
C4J65_RS00790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J65_RS00800	COG1063	alcohol dehydrogenase
C4J65_RS00810	COG0589	response to stress
C4J65_RS00840	COG0745	RESPONSE REGULATOR receiver
C4J65_RS00865	COG0702	epimerase
C4J65_RS00880	COG0142	geranyltranstransferase activity
C4J65_RS00900	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C4J65_RS00960	COG0242	peptide deformylase activity
C4J65_RS00965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J65_RS00970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4J65_RS00975	COG1609	Transcriptional regulator
C4J65_RS00990	COG0583	DNA-binding transcription factor activity
C4J65_RS01000	COG4221	oxidoreductase activity
C4J65_RS01015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J65_RS01025	COG0517	IMP dehydrogenase activity
C4J65_RS01035	COG3903	Transcriptional regulator
C4J65_RS01035	COG3629	intracellular signal transduction
C4J65_RS01040	COG0596	Alpha beta hydrolase
C4J65_RS01070	COG2409	Drug exporters of the RND superfamily
C4J65_RS01080	COG2084	Dehydrogenase
C4J65_RS01095	COG3572	ergothioneine biosynthetic process
C4J65_RS01100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4J65_RS01105	COG0121	glutamine amidotransferase
C4J65_RS01110	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C4J65_RS01115	COG2182	Extracellular solute-binding protein
C4J65_RS01120	COG3360	Dodecin
C4J65_RS01130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS01155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4J65_RS01160	COG1053	succinate dehydrogenase
C4J65_RS01170	COG0583	DNA-binding transcription factor activity
C4J65_RS01180	COG0583	DNA-binding transcription factor activity
C4J65_RS01225	COG0726	polysaccharide deacetylase
C4J65_RS01235	COG0531	amino acid
C4J65_RS01270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J65_RS01295	COG0395	ABC-type sugar transport system, permease component
C4J65_RS01300	COG1175	transmembrane transport
C4J65_RS01305	COG1653	transport
C4J65_RS01310	COG1609	Transcriptional regulator
C4J65_RS01350	COG3537	Alpha-1,2-mannosidase
C4J65_RS01360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4J65_RS01365	COG0297	glycogen (starch) synthase activity
C4J65_RS01390	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4J65_RS01410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C4J65_RS01415	COG0456	acetyltransferase
C4J65_RS01420	COG0583	DNA-binding transcription factor activity
C4J65_RS01425	COG0583	DNA-binding transcription factor activity
C4J65_RS01445	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J65_RS01445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J65_RS01455	COG1846	Transcriptional regulator
C4J65_RS01460	COG1902	pentaerythritol trinitrate reductase activity
C4J65_RS01460	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J65_RS01465	COG2130	NADP-dependent
C4J65_RS01470	COG1309	transcriptional regulator
C4J65_RS01475	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS01485	COG1073	alpha beta
C4J65_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS01515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS01520	COG1917	Cupin 2, conserved barrel domain protein
C4J65_RS01520	COG4977	sequence-specific DNA binding
C4J65_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS01560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4J65_RS01565	COG0463	Glycosyl transferase, family 2
C4J65_RS01600	COG1349	DNA-binding transcription factor activity
C4J65_RS01610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J65_RS01625	COG0577	efflux transmembrane transporter activity
C4J65_RS01630	COG1136	(ABC) transporter
C4J65_RS01665	COG1940	carbohydrate kinase activity
C4J65_RS01675	COG2813	Specifically methylates the guanine in position
C4J65_RS01695	COG2608	mercury ion transmembrane transporter activity
C4J65_RS01720	COG0783	Belongs to the Dps family
C4J65_RS01735	COG1501	Belongs to the glycosyl hydrolase 31 family
C4J65_RS01745	COG1175	transmembrane transport
C4J65_RS01750	COG0395	ABC-type sugar transport system, permease component
C4J65_RS01755	COG2723	6-phospho-beta-galactosidase activity
C4J65_RS01775	COG3250	beta-galactosidase activity
C4J65_RS01780	COG0395	ABC-type sugar transport system, permease component
C4J65_RS01785	COG1175	transmembrane transport
C4J65_RS01795	COG1609	Transcriptional regulator
C4J65_RS01820	COG2197	response regulator
C4J65_RS01825	COG4585	Histidine kinase
C4J65_RS01830	COG0445	tRNA wobble uridine modification
C4J65_RS01840	COG1660	Displays ATPase and GTPase activities
C4J65_RS01870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4J65_RS01890	COG0204	Acyl-transferase
C4J65_RS01915	COG0584	glycerophosphoryl diester phosphodiesterase
C4J65_RS01955	COG0671	phosphoesterase, PA-phosphatase related
C4J65_RS01965	COG1309	transcriptional regulator
C4J65_RS01985	COG0640	Transcriptional regulator
C4J65_RS01990	COG1902	pentaerythritol trinitrate reductase activity
C4J65_RS02005	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS02015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4J65_RS02030	COG2706	6-phosphogluconolactonase activity
C4J65_RS02045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J65_RS02080	COG4221	oxidoreductase activity
C4J65_RS02095	COG3387	PFAM Glycoside hydrolase 15-related
C4J65_RS02105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J65_RS02110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4J65_RS02115	COG2080	2 iron, 2 sulfur cluster binding
C4J65_RS02125	COG4565	transcriptional regulatory protein
C4J65_RS02130	COG3290	protein histidine kinase activity
C4J65_RS02155	COG0432	Pfam Uncharacterised protein family UPF0047
C4J65_RS02160	COG2072	flavoprotein involved in K transport
C4J65_RS02175	COG1132	(ABC) transporter
C4J65_RS02190	COG1132	(ABC) transporter
C4J65_RS02195	COG1132	(ABC) transporter
C4J65_RS02205	COG0254	rRNA binding
C4J65_RS02220	COG1946	Acyl-CoA thioesterase
C4J65_RS02230	COG2018	Roadblock/LC7 domain
C4J65_RS02300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J65_RS02310	COG2115	Belongs to the xylose isomerase family
C4J65_RS02315	COG1070	Carbohydrate kinase
C4J65_RS02320	COG1846	Transcriptional regulator
C4J65_RS02320	COG1940	carbohydrate kinase activity
C4J65_RS02335	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS02345	COG2130	NADP-dependent
C4J65_RS02350	COG0604	alcohol dehydrogenase
C4J65_RS02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J65_RS02360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J65_RS02375	COG3629	intracellular signal transduction
C4J65_RS02415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J65_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS02445	COG0129	dihydroxy-acid dehydratase activity
C4J65_RS02450	COG1414	Transcriptional regulator
C4J65_RS02470	COG1609	Transcriptional regulator
C4J65_RS02480	COG0395	ABC-type sugar transport system, permease component
C4J65_RS02485	COG1175	transmembrane transport
C4J65_RS02495	COG1621	beta-fructofuranosidase activity
C4J65_RS02525	COG0714	Associated with various cellular activities
C4J65_RS02565	COG0477	Major facilitator Superfamily
C4J65_RS02585	COG0477	Major facilitator Superfamily
C4J65_RS02600	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS02605	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS02615	COG3800	Transcriptional regulator
C4J65_RS02615	COG1396	sequence-specific DNA binding
C4J65_RS02620	COG0492	ferredoxin-NADP+ reductase activity
C4J65_RS02625	COG1793	dna ligase
C4J65_RS02630	COG0494	nUDIX hydrolase
C4J65_RS02635	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS02645	COG3424	synthase
C4J65_RS02650	COG2124	cytochrome p450
C4J65_RS02660	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS02670	COG0242	peptide deformylase activity
C4J65_RS02675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4J65_RS02680	COG3442	glutamine amidotransferase
C4J65_RS02685	COG0205	6-phosphofructokinase activity
C4J65_RS02700	COG3275	phosphorelay sensor kinase activity
C4J65_RS02705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J65_RS02715	COG3279	Response regulator of the LytR AlgR family
C4J65_RS02720	COG1522	sequence-specific DNA binding
C4J65_RS02725	COG1834	amidinotransferase
C4J65_RS02730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J65_RS02740	COG0477	Major facilitator Superfamily
C4J65_RS02755	COG0204	Acyl-transferase
C4J65_RS02780	COG0740	serine-type endopeptidase activity
C4J65_RS02815	COG0156	8-amino-7-oxononanoate synthase activity
C4J65_RS02820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4J65_RS02825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4J65_RS02830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4J65_RS02835	COG2226	methyltransferase
C4J65_RS02850	COG0456	acetyltransferase
C4J65_RS02870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4J65_RS02890	COG0604	alcohol dehydrogenase
C4J65_RS02890	COG3321	synthase
C4J65_RS02915	COG1611	Belongs to the LOG family
C4J65_RS02920	COG3629	intracellular signal transduction
C4J65_RS02920	COG3903	Transcriptional regulator
C4J65_RS02960	COG3251	PFAM MbtH domain protein
C4J65_RS03010	COG1131	(ABC) transporter
C4J65_RS03015	COG4585	Histidine kinase
C4J65_RS03020	COG2197	response regulator
C4J65_RS03025	COG1940	carbohydrate kinase activity
C4J65_RS03030	COG2188	Transcriptional regulator
C4J65_RS03035	COG1595	DNA-templated transcription, initiation
C4J65_RS03040	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J65_RS03040	COG0596	Alpha beta hydrolase
C4J65_RS03050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS03055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS03065	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J65_RS03070	COG0022	dehydrogenase e1 component
C4J65_RS03070	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J65_RS03075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4J65_RS03080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4J65_RS03085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS03090	COG3320	Male sterility
C4J65_RS03090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS03115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4J65_RS03120	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C4J65_RS03170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J65_RS03195	COG0626	cystathionine gamma-synthase activity
C4J65_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS03225	COG1522	sequence-specific DNA binding
C4J65_RS03230	COG0419	ATPase involved in DNA repair
C4J65_RS03235	COG0420	3'-5' exonuclease activity
C4J65_RS03240	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS03240	COG1024	Enoyl-CoA hydratase
C4J65_RS03255	COG1309	transcriptional regulator
C4J65_RS03270	COG1739	Uncharacterized protein family UPF0029
C4J65_RS03280	COG1832	CoA-binding protein
C4J65_RS03285	COG3864	Putative metallopeptidase domain
C4J65_RS03290	COG0714	Associated with various cellular activities
C4J65_RS03305	COG0640	Transcriptional regulator
C4J65_RS03330	COG0110	maltose O-acetyltransferase activity
C4J65_RS03365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4J65_RS03380	COG0183	Belongs to the thiolase family
C4J65_RS03390	COG1968	undecaprenyl-diphosphatase activity
C4J65_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS03405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4J65_RS03415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J65_RS03425	COG2318	DinB family
C4J65_RS03440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4J65_RS03445	COG4166	transmembrane transport
C4J65_RS03475	COG0006	proline dipeptidase activity
C4J65_RS03485	COG0723	plastoquinol--plastocyanin reductase activity
C4J65_RS03500	COG0697	spore germination
C4J65_RS03540	COG1136	(ABC) transporter
C4J65_RS03555	COG2197	response regulator
C4J65_RS03585	COG1609	Transcriptional regulator
C4J65_RS03600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J65_RS03600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J65_RS03610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4J65_RS03630	COG1716	ATPase activity
C4J65_RS03650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4J65_RS03680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J65_RS03690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J65_RS03705	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4J65_RS03710	COG3706	GGDEF domain
C4J65_RS03725	COG2018	Roadblock/LC7 domain
C4J65_RS03740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J65_RS03745	COG2146	nitrite reductase [NAD(P)H] activity
C4J65_RS03750	COG1414	Transcriptional regulator
C4J65_RS03765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J65_RS03795	COG2814	Major facilitator Superfamily
C4J65_RS03800	COG4336	lyase activity
C4J65_RS03805	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS03810	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS03845	COG2364	Membrane
C4J65_RS03855	COG2270	Major facilitator Superfamily
C4J65_RS03870	COG0463	Glycosyl transferase, family 2
C4J65_RS03895	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS03945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4J65_RS03950	COG0140	phosphoribosyl-ATP diphosphatase activity
C4J65_RS03955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J65_RS03960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J65_RS03960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J65_RS03965	COG3201	nicotinamide mononucleotide transporter
C4J65_RS03985	COG2223	nitrite transmembrane transporter activity
C4J65_RS03995	COG2233	PERMEase
C4J65_RS04020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J65_RS04055	COG2390	Transcriptional regulator
C4J65_RS04060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4J65_RS04065	COG1653	transport
C4J65_RS04100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J65_RS04115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4J65_RS04125	COG1758	RNA polymerase activity
C4J65_RS04130	COG0194	GDP metabolic process
C4J65_RS04140	COG0284	orotidine-5'-phosphate decarboxylase activity
C4J65_RS04145	COG0167	dihydroorotate dehydrogenase activity
C4J65_RS04150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4J65_RS04155	COG0505	Belongs to the CarA family
C4J65_RS04165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J65_RS04170	COG0540	Belongs to the ATCase OTCase family
C4J65_RS04175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4J65_RS04185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4J65_RS04190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4J65_RS04195	COG0006	proline dipeptidase activity
C4J65_RS04205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4J65_RS04210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4J65_RS04220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J65_RS04235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4J65_RS04240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J65_RS04260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4J65_RS04275	COG0124	histidyl-tRNA synthetase
C4J65_RS04285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4J65_RS04290	COG1196	nuclear chromosome segregation
C4J65_RS04295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J65_RS04300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J65_RS04305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4J65_RS04310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4J65_RS04320	COG2255	four-way junction helicase activity
C4J65_RS04325	COG0632	four-way junction helicase activity
C4J65_RS04330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4J65_RS04335	COG0217	transcriptional regulatory protein
C4J65_RS04340	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C4J65_RS04345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C4J65_RS04355	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS04360	COG1560	Kdo2-lipid A biosynthetic process
C4J65_RS04365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4J65_RS04385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J65_RS04400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J65_RS04425	COG0395	ABC-type sugar transport system, permease component
C4J65_RS04430	COG1175	transmembrane transport
C4J65_RS04475	COG0456	acetyltransferase
C4J65_RS04485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J65_RS04540	COG1648	precorrin-2 dehydrogenase activity
C4J65_RS04540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J65_RS04545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4J65_RS04560	COG1464	Belongs to the NlpA lipoprotein family
C4J65_RS04565	COG2011	ABC-type metal ion transport system permease component
C4J65_RS04570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J65_RS04575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J65_RS04600	COG0584	glycerophosphoryl diester phosphodiesterase
C4J65_RS04605	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS04605	COG0204	Acyl-transferase
C4J65_RS04610	COG0477	Major facilitator Superfamily
C4J65_RS04625	COG0165	Argininosuccinate lyase
C4J65_RS04655	COG1438	arginine binding
C4J65_RS04660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J65_RS04665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J65_RS04670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4J65_RS04675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4J65_RS04715	COG0697	spore germination
C4J65_RS04725	COG1649	PFAM Uncharacterised BCR, COG1649
C4J65_RS04760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J65_RS04775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J65_RS04775	COG0072	phenylalanine-tRNA ligase activity
C4J65_RS04780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J65_RS04785	COG5002	protein histidine kinase activity
C4J65_RS04790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4J65_RS04795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4J65_RS04800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4J65_RS04805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4J65_RS04850	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS04855	COG0174	glutamine synthetase
C4J65_RS04865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4J65_RS04890	COG4176	ABC-type proline glycine betaine transport system permease component
C4J65_RS04895	COG4175	Glycine betaine
C4J65_RS04895	COG0517	IMP dehydrogenase activity
C4J65_RS04900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4J65_RS04915	COG0564	pseudouridine synthase activity
C4J65_RS04950	COG0805	protein transport
C4J65_RS04955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J65_RS04985	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J65_RS04990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C4J65_RS05000	COG1609	Transcriptional regulator
C4J65_RS05005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C4J65_RS05010	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C4J65_RS05025	COG4122	O-methyltransferase activity
C4J65_RS05030	COG1222	aaa ATPase
C4J65_RS05050	COG1994	Peptidase M50
C4J65_RS05050	COG0517	IMP dehydrogenase activity
C4J65_RS05065	COG2197	response regulator
C4J65_RS05070	COG4166	transmembrane transport
C4J65_RS05080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J65_RS05085	COG0646	methionine synthase
C4J65_RS05085	COG1410	methionine synthase
C4J65_RS05090	COG1414	Transcriptional regulator
C4J65_RS05095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4J65_RS05100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J65_RS05105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4J65_RS05115	COG0215	cysteine-tRNA ligase activity
C4J65_RS05130	COG0588	phosphoglycerate mutase activity
C4J65_RS05135	COG0598	Magnesium transport protein CorA
C4J65_RS05145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS05150	COG0667	Aldo Keto reductase
C4J65_RS05190	COG3012	SEC-C Motif Domain Protein
C4J65_RS05195	COG2186	Transcriptional regulator
C4J65_RS05200	COG3265	gluconokinase activity
C4J65_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS05215	COG1063	alcohol dehydrogenase
C4J65_RS05235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4J65_RS05250	COG2149	membrane
C4J65_RS05280	COG3876	Protein conserved in bacteria
C4J65_RS05325	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS05335	COG0640	Transcriptional regulator
C4J65_RS05355	COG3842	ATPase activity
C4J65_RS05370	COG2851	Citrate transporter
C4J65_RS05375	COG0243	molybdopterin cofactor binding
C4J65_RS05380	COG1309	transcriptional regulator
C4J65_RS05395	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4J65_RS05400	COG2188	Transcriptional regulator
C4J65_RS05435	COG1595	DNA-templated transcription, initiation
C4J65_RS05445	COG2755	lipolytic protein G-D-S-L family
C4J65_RS05460	COG1725	Transcriptional regulator
C4J65_RS05515	COG0587	DNA-directed DNA polymerase activity
C4J65_RS05540	COG2197	response regulator
C4J65_RS05560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS05575	COG1799	cell septum assembly
C4J65_RS05590	COG0477	Major facilitator Superfamily
C4J65_RS05600	COG0671	phosphoesterase, PA-phosphatase related
C4J65_RS05625	COG1160	GTP binding
C4J65_RS05635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4J65_RS05660	COG3541	Predicted nucleotidyltransferase
C4J65_RS05675	COG1187	pseudouridine synthase activity
C4J65_RS05680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4J65_RS05685	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4J65_RS05700	COG0686	Belongs to the AlaDH PNT family
C4J65_RS05710	COG0494	nUDIX hydrolase
C4J65_RS05715	COG0504	CTP synthase activity
C4J65_RS05720	COG3387	PFAM Glycoside hydrolase 15-related
C4J65_RS05730	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS05735	COG0497	DNA recombination
C4J65_RS05740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4J65_RS05760	COG1120	ATPase activity
C4J65_RS05765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J65_RS05770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J65_RS05775	COG0647	UMP catabolic process
C4J65_RS05815	COG2094	Belongs to the DNA glycosylase MPG family
C4J65_RS05825	COG1881	PFAM PEBP family protein
C4J65_RS05845	COG1119	ATPase activity
C4J65_RS05860	COG2197	response regulator
C4J65_RS05870	COG4221	oxidoreductase activity
C4J65_RS05875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4J65_RS05885	COG1131	(ABC) transporter
C4J65_RS05885	COG1716	ATPase activity
C4J65_RS05885	COG0842	Transport permease protein
C4J65_RS05895	COG0560	Phosphoserine phosphatase
C4J65_RS05895	COG3830	Belongs to the UPF0237 family
C4J65_RS05900	COG0588	phosphoglycerate mutase activity
C4J65_RS05920	COG2186	Transcriptional regulator
C4J65_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS05945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4J65_RS05965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J65_RS05970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J65_RS05980	COG1404	Belongs to the peptidase S8 family
C4J65_RS05995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J65_RS06010	COG3387	PFAM Glycoside hydrolase 15-related
C4J65_RS06050	COG1024	Enoyl-CoA hydratase
C4J65_RS06060	COG0488	(ABC) transporter
C4J65_RS06080	COG0235	Class ii aldolase
C4J65_RS06095	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4J65_RS06100	COG1492	cobalamin metabolic process
C4J65_RS06120	COG1797	cobyrinic acid a,c-diamide synthase activity
C4J65_RS06150	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C4J65_RS06175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4J65_RS06180	COG0456	acetyltransferase
C4J65_RS06185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J65_RS06190	COG1917	Cupin 2, conserved barrel domain protein
C4J65_RS06195	COG5285	phytanoyl-CoA dioxygenase
C4J65_RS06220	COG1414	Transcriptional regulator
C4J65_RS06240	COG1595	DNA-templated transcription, initiation
C4J65_RS06255	COG4677	pectinesterase activity
C4J65_RS06260	COG3866	Pectate lyase
C4J65_RS06265	COG2755	lipolytic protein G-D-S-L family
C4J65_RS06290	COG0395	ABC-type sugar transport system, permease component
C4J65_RS06295	COG1175	transmembrane transport
C4J65_RS06310	COG1802	Transcriptional regulator
C4J65_RS06330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J65_RS06335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J65_RS06340	COG1349	DNA-binding transcription factor activity
C4J65_RS06360	COG1063	alcohol dehydrogenase
C4J65_RS06375	COG1309	transcriptional regulator
C4J65_RS06415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J65_RS06435	COG2171	N-acyltransferase activity
C4J65_RS06440	COG3226	Transcriptional regulator
C4J65_RS06445	COG2076	Multidrug Resistance protein
C4J65_RS06450	COG2151	metal-sulfur cluster biosynthetic enzyme
C4J65_RS06455	COG0822	iron-sulfur transferase activity
C4J65_RS06460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J65_RS06465	COG0396	ATPase activity
C4J65_RS06475	COG0719	Fe-S assembly protein
C4J65_RS06495	COG1131	(ABC) transporter
C4J65_RS06525	COG0109	protoheme IX farnesyltransferase activity
C4J65_RS06540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J65_RS06555	COG0363	glucosamine-6-phosphate deaminase activity
C4J65_RS06560	COG0166	Belongs to the GPI family
C4J65_RS06570	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4J65_RS06575	COG0149	triose-phosphate isomerase activity
C4J65_RS06580	COG0126	phosphoglycerate kinase activity
C4J65_RS06585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4J65_RS06595	COG1481	regulation of sporulation
C4J65_RS06600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4J65_RS06605	COG1660	Displays ATPase and GTPase activities
C4J65_RS06610	COG0322	excinuclease ABC activity
C4J65_RS06645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J65_RS06660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J65_RS06665	COG0387	Pfam Sodium calcium exchanger
C4J65_RS06685	COG0556	nucleotide-excision repair
C4J65_RS06695	COG0584	glycerophosphoryl diester phosphodiesterase
C4J65_RS06710	COG2313	pseudouridylate synthase activity
C4J65_RS06720	COG2226	methyltransferase
C4J65_RS06725	COG0598	Magnesium transport protein CorA
C4J65_RS06775	COG0402	S-adenosylhomocysteine deaminase activity
C4J65_RS06800	COG2267	carboxylic ester hydrolase activity
C4J65_RS06820	COG2226	methyltransferase
C4J65_RS06835	COG0237	dephospho-CoA kinase activity
C4J65_RS06855	COG2226	methyltransferase
C4J65_RS06860	COG1643	Atp-dependent helicase
C4J65_RS06885	COG2050	protein possibly involved in aromatic compounds catabolism
C4J65_RS06945	COG0737	Belongs to the 5'-nucleotidase family
C4J65_RS06965	COG0287	Prephenate dehydrogenase
C4J65_RS06965	COG1605	Chorismate mutase
C4J65_RS06975	COG2968	Membrane
C4J65_RS06980	COG2304	oxidoreductase activity
C4J65_RS07000	COG0067	glutamate synthase
C4J65_RS07000	COG0069	glutamate synthase activity
C4J65_RS07000	COG0070	glutamate synthase
C4J65_RS07030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J65_RS07035	COG2301	Belongs to the HpcH HpaI aldolase family
C4J65_RS07040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4J65_RS07050	COG0159	tryptophan synthase activity
C4J65_RS07055	COG0133	tryptophan synthase activity
C4J65_RS07065	COG0134	indole-3-glycerol-phosphate synthase activity
C4J65_RS07090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4J65_RS07110	COG0107	imidazoleglycerol-phosphate synthase activity
C4J65_RS07115	COG0251	oxidation-reduction process
C4J65_RS07120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4J65_RS07125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4J65_RS07130	COG0131	Imidazoleglycerol-phosphate dehydratase
C4J65_RS07135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J65_RS07140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4J65_RS07160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4J65_RS07180	COG1432	Conserved Protein
C4J65_RS07190	COG0587	DNA-directed DNA polymerase activity
C4J65_RS07240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J65_RS07250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4J65_RS07255	COG3599	regulation of cell shape
C4J65_RS07265	COG1799	cell septum assembly
C4J65_RS07275	COG1496	oxidoreductase activity
C4J65_RS07280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4J65_RS07290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4J65_RS07295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J65_RS07305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4J65_RS07310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J65_RS07320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J65_RS07325	COG0768	penicillin binding
C4J65_RS07335	COG0275	rRNA processing
C4J65_RS07345	COG0714	Associated with various cellular activities
C4J65_RS07375	COG1309	transcriptional regulator
C4J65_RS07395	COG0352	thiamine-phosphate diphosphorylase activity
C4J65_RS07415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J65_RS07415	COG2022	thiamine diphosphate biosynthetic process
C4J65_RS07425	COG2022	thiamine diphosphate biosynthetic process
C4J65_RS07430	COG0515	serine threonine protein kinase
C4J65_RS07430	COG2815	serine threonine protein kinase
C4J65_RS07435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C4J65_RS07440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J65_RS07445	COG2193	ferroxidase activity
C4J65_RS07455	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4J65_RS07470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J65_RS07475	COG0205	6-phosphofructokinase activity
C4J65_RS07480	COG2197	response regulator
C4J65_RS07485	COG4585	Histidine kinase
C4J65_RS07510	COG1940	carbohydrate kinase activity
C4J65_RS07520	COG0003	Pfam Anion-transporting ATPase
C4J65_RS07535	COG1022	Amp-dependent synthetase and ligase
C4J65_RS07540	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS07590	COG2205	protein histidine kinase activity
C4J65_RS07595	COG0745	RESPONSE REGULATOR receiver
C4J65_RS07605	COG1929	Belongs to the glycerate kinase type-1 family
C4J65_RS07610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J65_RS07615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J65_RS07620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4J65_RS07625	COG0723	plastoquinol--plastocyanin reductase activity
C4J65_RS07630	COG2010	Cytochrome c
C4J65_RS07635	COG1845	cytochrome c oxidase, subunit III
C4J65_RS07645	COG1376	ErfK ybiS ycfS ynhG family protein
C4J65_RS07655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J65_RS07660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J65_RS07670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J65_RS07695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4J65_RS07705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J65_RS07710	COG2197	response regulator
C4J65_RS07715	COG4585	Histidine kinase
C4J65_RS07735	COG2226	methyltransferase
C4J65_RS07740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J65_RS07760	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4J65_RS07770	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4J65_RS07780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4J65_RS07785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J65_RS07790	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J65_RS07800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J65_RS07845	COG0321	lipoyl(octanoyl) transferase activity
C4J65_RS07850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4J65_RS07870	COG0174	glutamine synthetase
C4J65_RS07880	COG0702	epimerase
C4J65_RS07885	COG1733	regulation of RNA biosynthetic process
C4J65_RS07890	COG0501	Belongs to the peptidase M48B family
C4J65_RS07945	COG0745	RESPONSE REGULATOR receiver
C4J65_RS07960	COG2197	response regulator
C4J65_RS07990	COG1309	transcriptional regulator
C4J65_RS08010	COG0366	Alpha amylase catalytic
C4J65_RS08015	COG3833	ABC-type maltose transport systems, permease component
C4J65_RS08020	COG1175	transmembrane transport
C4J65_RS08030	COG1609	Transcriptional regulator
C4J65_RS08040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4J65_RS08050	COG2161	toxin-antitoxin pair type II binding
C4J65_RS08055	COG4115	mRNA cleavage
C4J65_RS08065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J65_RS08065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J65_RS08080	COG0174	glutamine synthetase
C4J65_RS08100	COG0667	Aldo Keto reductase
C4J65_RS08140	COG2814	Major facilitator Superfamily
C4J65_RS08150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4J65_RS08170	COG1994	Peptidase M50
C4J65_RS08220	COG2837	iron assimilation
C4J65_RS08225	COG0672	)-iron permease
C4J65_RS08245	COG2197	response regulator
C4J65_RS08260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J65_RS08265	COG2814	Major facilitator Superfamily
C4J65_RS08275	COG3540	Alkaline phosphatase
C4J65_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS08330	COG3022	response to hydroperoxide
C4J65_RS08335	COG0800	Aldolase
C4J65_RS08350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4J65_RS08365	COG2030	dehydratase
C4J65_RS08370	COG1131	(ABC) transporter
C4J65_RS08380	COG4585	Histidine kinase
C4J65_RS08385	COG2197	response regulator
C4J65_RS08395	COG0477	Major facilitator Superfamily
C4J65_RS08405	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J65_RS08405	COG2247	cell wall binding repeat
C4J65_RS08430	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS08435	COG1309	transcriptional regulator
C4J65_RS08445	COG1657	PFAM Prenyltransferase squalene oxidase
C4J65_RS08460	COG3845	ABC transporter
C4J65_RS08520	COG2801	Transposase and inactivated derivatives
C4J65_RS08520	COG3415	Transposase
C4J65_RS08560	COG4122	O-methyltransferase activity
C4J65_RS08695	COG4585	Histidine kinase
C4J65_RS08700	COG0586	Pfam SNARE associated Golgi protein
C4J65_RS08710	COG1358	cellular component organization or biogenesis
C4J65_RS08760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J65_RS08770	COG0477	Major facilitator Superfamily
C4J65_RS08775	COG1309	transcriptional regulator
C4J65_RS08790	COG0667	Aldo Keto reductase
C4J65_RS08795	COG0789	Transcriptional regulator
C4J65_RS08855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4J65_RS08860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS08865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS08895	COG1764	response to oxidative stress
C4J65_RS08900	COG2130	NADP-dependent
C4J65_RS08940	COG1129	ABC transporter
C4J65_RS08945	COG4214	carbohydrate transport
C4J65_RS08955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J65_RS08990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4J65_RS09015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J65_RS09025	COG1127	ABC transporter
C4J65_RS09050	COG3507	Belongs to the glycosyl hydrolase 43 family
C4J65_RS09080	COG0395	ABC-type sugar transport system, permease component
C4J65_RS09085	COG1175	transmembrane transport
C4J65_RS09115	COG3386	PFAM SMP-30 Gluconolaconase
C4J65_RS09120	COG1414	Transcriptional regulator
C4J65_RS09130	COG2186	Transcriptional regulator
C4J65_RS09140	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS09145	COG0825	malonyl-CoA metabolic process
C4J65_RS09145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4J65_RS09150	COG1404	Belongs to the peptidase S8 family
C4J65_RS09170	COG0515	serine threonine protein kinase
C4J65_RS09170	COG2815	serine threonine protein kinase
C4J65_RS09175	COG1077	Cell shape determining protein MreB Mrl
C4J65_RS09205	COG1070	Carbohydrate kinase
C4J65_RS09220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J65_RS09230	COG0358	DNA primase activity
C4J65_RS09240	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C4J65_RS09250	COG2949	membrane
C4J65_RS09255	COG0243	molybdopterin cofactor binding
C4J65_RS09270	COG0583	DNA-binding transcription factor activity
C4J65_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS09315	COG2146	nitrite reductase [NAD(P)H] activity
C4J65_RS09315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J65_RS09325	COG1309	transcriptional regulator
C4J65_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS09345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4J65_RS09350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J65_RS09350	COG0574	Belongs to the PEP-utilizing enzyme family
C4J65_RS09375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4J65_RS09395	COG0477	Major facilitator Superfamily
C4J65_RS09405	COG0423	glycine-tRNA ligase activity
C4J65_RS09410	COG3443	Belongs to the bacterial solute-binding protein 9 family
C4J65_RS09410	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4J65_RS09415	COG1121	(ABC) transporter
C4J65_RS09420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J65_RS09430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4J65_RS09435	COG1381	Involved in DNA repair and RecF pathway recombination
C4J65_RS09470	COG2197	response regulator
C4J65_RS09480	COG2409	Drug exporters of the RND superfamily
C4J65_RS09525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J65_RS09550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4J65_RS09560	COG2315	Protein conserved in bacteria
C4J65_RS09595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4J65_RS09600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J65_RS09605	COG4948	Mandelate Racemase Muconate Lactonizing
C4J65_RS09615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J65_RS09620	COG1234	tRNA 3'-trailer cleavage
C4J65_RS09625	COG0537	adenosine 5'-monophosphoramidase activity
C4J65_RS09630	COG4946	Tricorn protease homolog
C4J65_RS09630	COG0793	Belongs to the peptidase S41A family
C4J65_RS09655	COG0484	heat shock protein binding
C4J65_RS09660	COG1420	regulation of RNA biosynthetic process
C4J65_RS09695	COG0481	GTPase activity
C4J65_RS09705	COG0268	Binds directly to 16S ribosomal RNA
C4J65_RS09720	COG2353	YceI-like domain
C4J65_RS09745	COG1234	tRNA 3'-trailer cleavage
C4J65_RS09755	COG1307	EDD domain protein, DegV family
C4J65_RS09765	COG0495	leucyl-tRNA aminoacylation
C4J65_RS09775	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4J65_RS09800	COG0406	alpha-ribazole phosphatase activity
C4J65_RS09805	COG0799	negative regulation of ribosome biogenesis
C4J65_RS09815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4J65_RS09830	COG0501	Belongs to the peptidase M48B family
C4J65_RS09845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4J65_RS09855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4J65_RS09870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4J65_RS09875	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4J65_RS09885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4J65_RS09885	COG1215	transferase activity, transferring glycosyl groups
C4J65_RS09895	COG0463	Glycosyl transferase, family 2
C4J65_RS09900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4J65_RS09905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4J65_RS09910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4J65_RS09940	COG0673	inositol 2-dehydrogenase activity
C4J65_RS09950	COG1530	ribonuclease E activity
C4J65_RS09990	COG2186	Transcriptional regulator
C4J65_RS10030	COG0772	Belongs to the SEDS family
C4J65_RS10035	COG0768	penicillin binding
C4J65_RS10050	COG1077	Cell shape determining protein MreB Mrl
C4J65_RS10055	COG0105	UTP biosynthetic process
C4J65_RS10065	COG0285	dihydrofolate synthase activity
C4J65_RS10070	COG0525	valine-tRNA ligase activity
C4J65_RS10080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4J65_RS10085	COG0740	serine-type endopeptidase activity
C4J65_RS10090	COG0740	serine-type endopeptidase activity
C4J65_RS10095	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4J65_RS10125	COG3594	Acyltransferase
C4J65_RS10140	COG4552	Acetyltransferase involved in intracellular survival and related
C4J65_RS10150	COG0698	ribose 5-phosphate isomerase
C4J65_RS10155	COG1113	amino acid transport
C4J65_RS10160	COG1268	BioY protein
C4J65_RS10165	COG1113	amino acid transport
C4J65_RS10170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4J65_RS10185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J65_RS10190	COG1116	anion transmembrane transporter activity
C4J65_RS10210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C4J65_RS10270	COG0697	spore germination
C4J65_RS10275	COG1846	Transcriptional regulator
C4J65_RS10310	COG0668	transmembrane transport
C4J65_RS10320	COG1653	transport
C4J65_RS10325	COG1175	transmembrane transport
C4J65_RS10330	COG0395	ABC-type sugar transport system, permease component
C4J65_RS10335	COG1486	melibiose metabolic process
C4J65_RS10355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J65_RS10365	COG0515	serine threonine protein kinase
C4J65_RS10385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4J65_RS10405	COG0577	efflux transmembrane transporter activity
C4J65_RS10405	COG1136	(ABC) transporter
C4J65_RS10435	COG0629	single-stranded DNA binding
C4J65_RS10530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J65_RS10545	COG2304	oxidoreductase activity
C4J65_RS10575	COG0297	glycogen (starch) synthase activity
C4J65_RS10580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4J65_RS10600	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS10660	COG1131	(ABC) transporter
C4J65_RS10705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J65_RS10740	COG0640	Transcriptional regulator
C4J65_RS10755	COG1595	DNA-templated transcription, initiation
C4J65_RS10765	COG1609	Transcriptional regulator
C4J65_RS10770	COG1129	ABC transporter
C4J65_RS10775	COG1879	ABC-type sugar transport system periplasmic component
C4J65_RS10780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J65_RS10785	COG1869	D-ribose catabolic process
C4J65_RS10800	COG0673	inositol 2-dehydrogenase activity
C4J65_RS10850	COG1472	Belongs to the glycosyl hydrolase 3 family
C4J65_RS10880	COG2356	endonuclease I
C4J65_RS10915	COG1946	Acyl-CoA thioesterase
C4J65_RS10925	COG1309	transcriptional regulator
C4J65_RS10930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J65_RS10945	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS10965	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C4J65_RS10995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J65_RS11000	COG0589	response to stress
C4J65_RS11010	COG4977	sequence-specific DNA binding
C4J65_RS11015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4J65_RS11040	COG0395	ABC-type sugar transport system, permease component
C4J65_RS11060	COG0745	RESPONSE REGULATOR receiver
C4J65_RS11070	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4J65_RS11125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS11130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS11180	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS11200	COG0702	epimerase
C4J65_RS11205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C4J65_RS11225	COG4106	trans-aconitate 2-methyltransferase activity
C4J65_RS11235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS11290	COG2801	Transposase and inactivated derivatives
C4J65_RS11290	COG3415	Transposase
C4J65_RS11300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J65_RS11305	COG0765	amino acid transport
C4J65_RS11310	COG0765	amino acid transport
C4J65_RS11315	COG1126	abc transporter atp-binding protein
C4J65_RS11330	COG3397	chitin binding
C4J65_RS11390	COG0673	inositol 2-dehydrogenase activity
C4J65_RS11395	COG4702	Belongs to the UPF0303 family
C4J65_RS11445	COG0556	nucleotide-excision repair
C4J65_RS11500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J65_RS11550	COG2124	cytochrome p450
C4J65_RS11555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J65_RS11580	COG2733	membrane
C4J65_RS11595	COG4555	ABC transporter
C4J65_RS11610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4J65_RS11640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4J65_RS11650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4J65_RS11655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J65_RS11660	COG1263	PTS System
C4J65_RS11665	COG1263	PTS System
C4J65_RS11670	COG1234	tRNA 3'-trailer cleavage
C4J65_RS11700	COG1113	amino acid transport
C4J65_RS11715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4J65_RS11725	COG1335	isochorismatase
C4J65_RS11745	COG1714	RDD family
C4J65_RS11760	COG0277	FAD linked oxidase domain protein
C4J65_RS11770	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4J65_RS11780	COG1174	glycine betaine transport
C4J65_RS11790	COG1174	glycine betaine transport
C4J65_RS11800	COG3480	Lon protease (S16) C-terminal proteolytic domain
C4J65_RS11845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J65_RS11860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4J65_RS11865	COG0395	ABC-type sugar transport system, permease component
C4J65_RS11885	COG1678	Uncharacterized ACR, COG1678
C4J65_RS11890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4J65_RS11895	COG0776	regulation of translation
C4J65_RS11905	COG3973	AAA domain
C4J65_RS11935	COG2223	nitrite transmembrane transporter activity
C4J65_RS11960	COG0583	DNA-binding transcription factor activity
C4J65_RS11975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4J65_RS11980	COG0793	Belongs to the peptidase S41A family
C4J65_RS11990	COG2884	Cell division ATP-binding protein ftsE
C4J65_RS12005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4J65_RS12010	COG0515	serine threonine protein kinase
C4J65_RS12015	COG0515	serine threonine protein kinase
C4J65_RS12030	COG1175	transmembrane transport
C4J65_RS12035	COG0395	ABC-type sugar transport system, permease component
C4J65_RS12040	COG1216	Glycosyl transferase, family 2
C4J65_RS12045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4J65_RS12050	COG1216	Glycosyl transferase, family 2
C4J65_RS12065	COG1764	response to oxidative stress
C4J65_RS12070	COG1846	Transcriptional regulator
C4J65_RS12085	COG2318	DinB family
C4J65_RS12115	COG1134	teichoic acid transport
C4J65_RS12120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4J65_RS12125	COG1216	Glycosyl transferase, family 2
C4J65_RS12130	COG2902	Dehydrogenase
C4J65_RS12160	COG0653	protein targeting
C4J65_RS12170	COG3214	Protein conserved in bacteria
C4J65_RS12175	COG2197	response regulator
C4J65_RS12180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4J65_RS12195	COG0823	Involved in the tonB-independent uptake of proteins
C4J65_RS12200	COG5000	phosphorelay sensor kinase activity
C4J65_RS12200	COG5002	protein histidine kinase activity
C4J65_RS12205	COG0745	RESPONSE REGULATOR receiver
C4J65_RS12210	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4J65_RS12230	COG0714	Associated with various cellular activities
C4J65_RS12275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4J65_RS12285	COG1482	cell wall glycoprotein biosynthetic process
C4J65_RS12295	COG2835	tetraacyldisaccharide 4'-kinase activity
C4J65_RS12300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J65_RS12305	COG1620	l-lactate permease
C4J65_RS12345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4J65_RS12350	COG0778	Nitroreductase
C4J65_RS12350	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C4J65_RS12375	COG1316	TRANSCRIPTIONal
C4J65_RS12380	COG1316	TRANSCRIPTIONal
C4J65_RS12385	COG1316	TRANSCRIPTIONal
C4J65_RS12390	COG1316	TRANSCRIPTIONal
C4J65_RS12395	COG1316	TRANSCRIPTIONal
C4J65_RS12400	COG1316	TRANSCRIPTIONal
C4J65_RS12405	COG1316	TRANSCRIPTIONal
C4J65_RS12425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C4J65_RS12465	COG2205	protein histidine kinase activity
C4J65_RS12470	COG0745	RESPONSE REGULATOR receiver
C4J65_RS12475	COG3104	oligopeptide transport
C4J65_RS12505	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J65_RS12510	COG1191	sigma factor activity
C4J65_RS12520	COG1228	amidohydrolase
C4J65_RS12530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J65_RS12535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4J65_RS12560	COG2755	lipolytic protein G-D-S-L family
C4J65_RS12565	COG0183	Belongs to the thiolase family
C4J65_RS12635	COG1136	(ABC) transporter
C4J65_RS12640	COG1136	(ABC) transporter
C4J65_RS12640	COG0577	efflux transmembrane transporter activity
C4J65_RS12645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J65_RS12650	COG1252	NADH dehydrogenase
C4J65_RS12670	COG0148	phosphopyruvate hydratase activity
C4J65_RS12750	COG0577	efflux transmembrane transporter activity
C4J65_RS12755	COG1136	(ABC) transporter
C4J65_RS12765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J65_RS12795	COG4585	Histidine kinase
C4J65_RS12800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J65_RS12805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4J65_RS12810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4J65_RS12815	COG0193	aminoacyl-tRNA hydrolase activity
C4J65_RS12825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4J65_RS12835	COG1309	transcriptional regulator
C4J65_RS12840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J65_RS12850	COG4106	trans-aconitate 2-methyltransferase activity
C4J65_RS12855	COG1846	Transcriptional regulator
C4J65_RS12860	COG2197	response regulator
C4J65_RS12880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4J65_RS12925	COG0488	(ABC) transporter
C4J65_RS12930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4J65_RS12935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4J65_RS12945	COG0084	hydrolase, TatD family'
C4J65_RS12980	COG0768	penicillin binding
C4J65_RS12990	COG0310	cobalt ion transport
C4J65_RS13000	COG1122	ATPase activity
C4J65_RS13005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J65_RS13020	COG0442	prolyl-tRNA aminoacylation
C4J65_RS13025	COG2409	Drug exporters of the RND superfamily
C4J65_RS13035	COG0793	Belongs to the peptidase S41A family
C4J65_RS13035	COG4946	Tricorn protease homolog
C4J65_RS13050	COG2267	carboxylic ester hydrolase activity
C4J65_RS13055	COG2072	flavoprotein involved in K transport
C4J65_RS13065	COG0708	Exodeoxyribonuclease III
C4J65_RS13090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J65_RS13095	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4J65_RS13095	COG0315	cyclic pyranopterin monophosphate synthase activity
C4J65_RS13100	COG0315	cyclic pyranopterin monophosphate synthase activity
C4J65_RS13110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4J65_RS13115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4J65_RS13140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4J65_RS13150	COG1970	mechanosensitive ion channel activity
C4J65_RS13165	COG3191	aminopeptidase activity
C4J65_RS13180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J65_RS13180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J65_RS13180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J65_RS13190	COG1349	DNA-binding transcription factor activity
C4J65_RS13195	COG0477	Major facilitator Superfamily
C4J65_RS13210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J65_RS13215	COG1247	-acetyltransferase
C4J65_RS13220	COG3384	dioxygenase
C4J65_RS13225	COG1846	Transcriptional regulator
C4J65_RS13245	COG1414	Transcriptional regulator
C4J65_RS13250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4J65_RS13260	COG0134	indole-3-glycerol-phosphate synthase activity
C4J65_RS13265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J65_RS13270	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J65_RS13275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J65_RS13285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4J65_RS13290	COG3629	intracellular signal transduction
C4J65_RS13290	COG3903	Transcriptional regulator
C4J65_RS13330	COG4585	Histidine kinase
C4J65_RS13335	COG2197	response regulator
C4J65_RS13365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J65_RS13370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J65_RS13380	COG0510	thiamine kinase activity
C4J65_RS13385	COG1132	(ABC) transporter
C4J65_RS13390	COG2175	clavaminate synthase activity
C4J65_RS13400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4J65_RS13410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS13430	COG0667	Aldo Keto reductase
C4J65_RS13455	COG0667	Aldo Keto reductase
C4J65_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS13475	COG0604	alcohol dehydrogenase
C4J65_RS13475	COG3321	synthase
C4J65_RS13480	COG1309	transcriptional regulator
C4J65_RS13485	COG2807	transmembrane transport
C4J65_RS13500	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS13505	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS13515	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C4J65_RS13525	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS13530	COG1902	pentaerythritol trinitrate reductase activity
C4J65_RS13565	COG0789	Transcriptional regulator
C4J65_RS13570	COG0659	secondary active sulfate transmembrane transporter activity
C4J65_RS13610	COG4585	Histidine kinase
C4J65_RS13615	COG2197	response regulator
C4J65_RS13695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS13700	COG1742	UPF0060 membrane protein
C4J65_RS13710	COG1690	Belongs to the RtcB family
C4J65_RS13730	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C4J65_RS13735	COG0018	arginyl-trna synthetase
C4J65_RS13770	COG0113	porphobilinogen synthase activity
C4J65_RS13780	COG0604	alcohol dehydrogenase
C4J65_RS13780	COG3321	synthase
C4J65_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS13795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4J65_RS13805	COG1648	precorrin-2 dehydrogenase activity
C4J65_RS13805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J65_RS13810	COG0181	hydroxymethylbilane synthase activity
C4J65_RS13815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4J65_RS13820	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C4J65_RS13870	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4J65_RS13875	COG2223	nitrite transmembrane transporter activity
C4J65_RS13880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J65_RS13905	COG0180	Tryptophanyl-tRNA synthetase
C4J65_RS13915	COG1335	isochorismatase
C4J65_RS13920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4J65_RS13930	COG1129	ABC transporter
C4J65_RS13930	COG0842	Transport permease protein
C4J65_RS13960	COG0129	dihydroxy-acid dehydratase activity
C4J65_RS13965	COG1309	transcriptional regulator
C4J65_RS13970	COG1082	Xylose isomerase domain protein TIM barrel
C4J65_RS13975	COG0248	Ppx GppA phosphatase
C4J65_RS13995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C4J65_RS14010	COG1194	a g-specific adenine glycosylase
C4J65_RS14015	COG1595	DNA-templated transcription, initiation
C4J65_RS14025	COG0745	RESPONSE REGULATOR receiver
C4J65_RS14030	COG2205	protein histidine kinase activity
C4J65_RS14055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J65_RS14070	COG0739	heme binding
C4J65_RS14115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4J65_RS14140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4J65_RS14150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4J65_RS14155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4J65_RS14180	COG1660	Displays ATPase and GTPase activities
C4J65_RS14200	COG0649	NAD binding
C4J65_RS14225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4J65_RS14225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4J65_RS14250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J65_RS14265	COG0302	gtp cyclohydrolase
C4J65_RS14280	COG0037	tRNA processing
C4J65_RS14290	COG2027	D-alanyl-D-alanine carboxypeptidase
C4J65_RS14295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4J65_RS14305	COG0586	Pfam SNARE associated Golgi protein
C4J65_RS14310	COG0393	Putative heavy-metal-binding
C4J65_RS14315	COG0789	Transcriptional regulator
C4J65_RS14325	COG0076	glutamate decarboxylase activity
C4J65_RS14370	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS14400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4J65_RS14410	COG0254	rRNA binding
C4J65_RS14415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4J65_RS14420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4J65_RS14425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4J65_RS14445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4J65_RS14445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4J65_RS14470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4J65_RS14475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J65_RS14480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J65_RS14480	COG1754	DNA topoisomerase type I activity
C4J65_RS14500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4J65_RS14510	COG2172	sigma factor antagonist activity
C4J65_RS14515	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J65_RS14520	COG1111	helicase
C4J65_RS14520	COG1205	dead DEAH box helicase
C4J65_RS14580	COG0659	secondary active sulfate transmembrane transporter activity
C4J65_RS14585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J65_RS14590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J65_RS14600	COG2267	carboxylic ester hydrolase activity
C4J65_RS14615	COG0494	nUDIX hydrolase
C4J65_RS14635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J65_RS14645	COG0596	Alpha beta hydrolase
C4J65_RS14665	COG0003	Pfam Anion-transporting ATPase
C4J65_RS14680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J65_RS14680	COG4499	WXG100 protein secretion system (Wss), protein YukC
C4J65_RS14690	COG1408	metallophosphoesterase
C4J65_RS14715	COG2205	protein histidine kinase activity
C4J65_RS14720	COG0745	RESPONSE REGULATOR receiver
C4J65_RS14740	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J65_RS14745	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4J65_RS14750	COG1234	tRNA 3'-trailer cleavage
C4J65_RS14775	COG0475	glutathione-regulated potassium exporter activity
C4J65_RS14785	COG3263	regulation of cellular component size
C4J65_RS14805	COG2268	Band 7 protein
C4J65_RS14810	COG1585	Membrane protein implicated in regulation of membrane protease activity
C4J65_RS14835	COG1595	DNA-templated transcription, initiation
C4J65_RS14860	COG2814	Major facilitator Superfamily
C4J65_RS14865	COG0697	spore germination
C4J65_RS14870	COG0583	DNA-binding transcription factor activity
C4J65_RS14880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4J65_RS14885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4J65_RS14900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J65_RS14905	COG1802	Transcriptional regulator
C4J65_RS14935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4J65_RS14955	COG1131	(ABC) transporter
C4J65_RS14960	COG3559	Exporter of polyketide antibiotics
C4J65_RS14995	COG2197	response regulator
C4J65_RS15000	COG4585	Histidine kinase
C4J65_RS15005	COG2197	response regulator
C4J65_RS15010	COG4585	Histidine kinase
C4J65_RS15030	COG3844	kynureninase activity
C4J65_RS15045	COG0477	Major facilitator Superfamily
C4J65_RS15050	COG0191	fructose-bisphosphate aldolase activity
C4J65_RS15055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4J65_RS15070	COG2197	response regulator
C4J65_RS15075	COG4585	Histidine kinase
C4J65_RS15080	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4J65_RS15105	COG0542	response to heat
C4J65_RS15130	COG4213	ABC transporter substrate-binding protein
C4J65_RS15135	COG0789	Transcriptional regulator
C4J65_RS15140	COG0484	heat shock protein binding
C4J65_RS15145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4J65_RS15150	COG0443	Heat shock 70 kDa protein
C4J65_RS15160	COG0247	lactate metabolic process
C4J65_RS15160	COG2181	nitrate reductase activity
C4J65_RS15185	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C4J65_RS15190	COG0717	Belongs to the dCTP deaminase family
C4J65_RS15325	COG0640	Transcriptional regulator
C4J65_RS15330	COG2072	flavoprotein involved in K transport
C4J65_RS15335	COG0798	PFAM Bile acid sodium symporter
C4J65_RS15340	COG0640	Transcriptional regulator
C4J65_RS15345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4J65_RS15420	COG1252	NADH dehydrogenase
C4J65_RS15425	COG1595	DNA-templated transcription, initiation
C4J65_RS15430	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4J65_RS15435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4J65_RS15440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4J65_RS15520	COG0667	Aldo Keto reductase
C4J65_RS15525	COG1278	Cold shock
C4J65_RS15530	COG0513	Belongs to the DEAD box helicase family
C4J65_RS15565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4J65_RS15570	COG5002	protein histidine kinase activity
C4J65_RS15575	COG0745	RESPONSE REGULATOR receiver
C4J65_RS15590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J65_RS15610	COG1278	Cold shock
C4J65_RS15620	COG4585	Histidine kinase
C4J65_RS15630	COG1136	(ABC) transporter
C4J65_RS15630	COG0577	efflux transmembrane transporter activity
C4J65_RS15645	COG1136	(ABC) transporter
C4J65_RS15650	COG2197	response regulator
C4J65_RS15655	COG4585	Histidine kinase
C4J65_RS15660	COG3239	Fatty acid desaturase
C4J65_RS15725	COG0583	DNA-binding transcription factor activity
C4J65_RS15745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J65_RS15750	COG1957	nucleoside hydrolase
C4J65_RS15755	COG0366	Alpha amylase catalytic
C4J65_RS15815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J65_RS15825	COG1215	transferase activity, transferring glycosyl groups
C4J65_RS15830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4J65_RS15845	COG1741	Belongs to the pirin family
C4J65_RS15855	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS15860	COG1362	aminopeptidase activity
C4J65_RS15910	COG1802	Transcriptional regulator
C4J65_RS15935	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J65_RS15940	COG0022	dehydrogenase e1 component
C4J65_RS15960	COG0515	serine threonine protein kinase
C4J65_RS15965	COG0515	serine threonine protein kinase
C4J65_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS15980	COG0604	alcohol dehydrogenase
C4J65_RS15980	COG3321	synthase
C4J65_RS16025	COG1522	sequence-specific DNA binding
C4J65_RS16030	COG1309	transcriptional regulator
C4J65_RS16035	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS16090	COG0745	RESPONSE REGULATOR receiver
C4J65_RS16140	COG0475	glutathione-regulated potassium exporter activity
C4J65_RS16170	COG4770	biotin carboxylase activity
C4J65_RS16195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS16215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J65_RS16225	COG0604	alcohol dehydrogenase
C4J65_RS16225	COG3321	synthase
C4J65_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS16235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J65_RS16265	COG1716	ATPase activity
C4J65_RS16270	COG1716	ATPase activity
C4J65_RS16285	COG0768	penicillin binding
C4J65_RS16295	COG0515	serine threonine protein kinase
C4J65_RS16315	COG3764	Sortase (surface protein transpeptidase)
C4J65_RS16320	COG3764	Sortase (surface protein transpeptidase)
C4J65_RS16345	COG0705	Rhomboid family
C4J65_RS16360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4J65_RS16375	COG0515	serine threonine protein kinase
C4J65_RS16420	COG4249	Peptidase C14 caspase catalytic subunit p20
C4J65_RS16420	COG2319	Wd-40 repeat
C4J65_RS16420	COG4249	Peptidase C14 caspase catalytic subunit p20
C4J65_RS16420	COG2319	Wd-40 repeat
C4J65_RS16435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4J65_RS16440	COG0187	DNA topoisomerase II activity
C4J65_RS16445	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C4J65_RS16450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J65_RS16455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4J65_RS16460	COG0592	DNA-directed DNA polymerase activity
C4J65_RS16470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J65_RS16475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4J65_RS16480	COG0594	ribonuclease P activity
C4J65_RS16485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4J65_RS16490	COG0706	membrane insertase activity
C4J65_RS16500	COG0357	Ribosomal RNA small subunit methyltransferase G
C4J65_RS16505	COG1192	Involved in chromosome partitioning
C4J65_RS16520	COG3118	belongs to the thioredoxin family
C4J65_RS16525	COG0492	ferredoxin-NADP+ reductase activity
C4J65_RS16535	COG1595	DNA-templated transcription, initiation
C4J65_RS16555	COG0617	tRNA 3'-terminal CCA addition
C4J65_RS16580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J65_RS16605	COG0360	Binds together with S18 to 16S ribosomal RNA
C4J65_RS16610	COG0629	single-stranded DNA binding
C4J65_RS16615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4J65_RS16620	COG0359	binds to the 23S rRNA
C4J65_RS16630	COG0305	Participates in initiation and elongation during chromosome replication
C4J65_RS16650	COG2814	Major facilitator Superfamily
C4J65_RS16675	COG0626	cystathionine gamma-synthase activity
C4J65_RS16680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4J65_RS16685	COG1950	PFAM Membrane protein of
C4J65_RS16690	COG0662	Cupin 2, conserved barrel domain protein
C4J65_RS16715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4J65_RS16740	COG1609	Transcriptional regulator
C4J65_RS16745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J65_RS16750	COG1271	oxidase subunit
C4J65_RS16755	COG1294	oxidase, subunit
C4J65_RS16760	COG4988	ABC transporter
C4J65_RS16770	COG0739	heme binding
C4J65_RS16775	COG0561	phosphatase activity
C4J65_RS16785	COG1595	DNA-templated transcription, initiation
C4J65_RS16805	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C4J65_RS16840	COG0561	phosphatase activity
C4J65_RS16845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4J65_RS16850	COG0077	Prephenate dehydratase
C4J65_RS16855	COG2837	iron assimilation
C4J65_RS16870	COG1999	signal sequence binding
C4J65_RS16895	COG0006	proline dipeptidase activity
C4J65_RS16915	COG0653	protein targeting
C4J65_RS16930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J65_RS16935	COG0604	alcohol dehydrogenase
C4J65_RS16940	COG1309	transcriptional regulator
C4J65_RS16950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4J65_RS16990	COG1595	DNA-templated transcription, initiation
C4J65_RS16995	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS17000	COG2814	Major facilitator Superfamily
C4J65_RS17005	COG1309	transcriptional regulator
C4J65_RS17010	COG0784	Response regulator, receiver
C4J65_RS17040	COG0768	penicillin binding
C4J65_RS17045	COG1733	regulation of RNA biosynthetic process
C4J65_RS17075	COG0745	RESPONSE REGULATOR receiver
C4J65_RS17080	COG2205	protein histidine kinase activity
C4J65_RS17085	COG1215	transferase activity, transferring glycosyl groups
C4J65_RS17090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J65_RS17100	COG3467	pyridoxamine 5'-phosphate
C4J65_RS17120	COG2353	YceI-like domain
C4J65_RS17125	COG0477	Major facilitator Superfamily
C4J65_RS17140	COG1191	sigma factor activity
C4J65_RS17145	COG1191	sigma factor activity
C4J65_RS17265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4J65_RS17345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4J65_RS17385	COG0151	Belongs to the GarS family
C4J65_RS17400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4J65_RS17410	COG2197	response regulator
C4J65_RS17445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4J65_RS17450	COG0047	phosphoribosylformylglycinamidine synthase activity
C4J65_RS17455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4J65_RS17490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4J65_RS17500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4J65_RS17525	COG1643	Atp-dependent helicase
C4J65_RS17565	COG0513	Belongs to the DEAD box helicase family
C4J65_RS17645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J65_RS17645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J65_RS17675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4J65_RS17685	COG0579	oxidoreductase
C4J65_RS17715	COG1252	NADH dehydrogenase
C4J65_RS17755	COG2197	response regulator
C4J65_RS17760	COG4585	Histidine kinase
C4J65_RS17800	COG0739	heme binding
C4J65_RS17800	COG0741	lytic transglycosylase activity
C4J65_RS17800	COG1196	nuclear chromosome segregation
C4J65_RS17805	COG0671	phosphoesterase, PA-phosphatase related
C4J65_RS17810	COG0277	FAD linked oxidase domain protein
C4J65_RS17820	COG1937	Protein conserved in bacteria
C4J65_RS17830	COG0306	phosphate transporter
C4J65_RS17835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J65_RS17875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4J65_RS17905	COG0456	acetyltransferase
C4J65_RS17910	COG0737	Belongs to the 5'-nucleotidase family
C4J65_RS17915	COG1733	regulation of RNA biosynthetic process
C4J65_RS17930	COG0745	RESPONSE REGULATOR receiver
C4J65_RS17935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J65_RS17940	COG1609	Transcriptional regulator
C4J65_RS17945	COG0745	RESPONSE REGULATOR receiver
C4J65_RS18015	COG3485	protocatechuate 3,4-dioxygenase
C4J65_RS18030	COG0735	belongs to the Fur family
C4J65_RS18035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J65_RS18040	COG1490	D-aminoacyl-tRNA deacylase activity
C4J65_RS18055	COG4552	Acetyltransferase involved in intracellular survival and related
C4J65_RS18065	COG2188	Transcriptional regulator
C4J65_RS18075	COG2188	Transcriptional regulator
C4J65_RS18080	COG0546	phosphoglycolate phosphatase activity
C4J65_RS18140	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS18165	COG0588	phosphoglycerate mutase activity
C4J65_RS18190	COG2188	Transcriptional regulator
C4J65_RS18235	COG2207	Transcriptional regulator
C4J65_RS18235	COG3708	Transcriptional regulator
C4J65_RS18265	COG5002	protein histidine kinase activity
C4J65_RS18285	COG1329	Transcriptional regulator
C4J65_RS18295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4J65_RS18300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4J65_RS18305	COG0215	cysteine-tRNA ligase activity
C4J65_RS18310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4J65_RS18350	COG3842	ATPase activity
C4J65_RS18450	COG0464	growth
C4J65_RS18470	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4J65_RS18470	COG1672	PFAM Archaeal ATPase
C4J65_RS18530	COG1309	transcriptional regulator
C4J65_RS18535	COG1064	alcohol dehydrogenase
C4J65_RS18540	COG0494	nUDIX hydrolase
C4J65_RS18555	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4J65_RS18590	COG1940	carbohydrate kinase activity
C4J65_RS18595	COG1653	transport
C4J65_RS18625	COG0463	Glycosyl transferase, family 2
C4J65_RS18640	COG1278	Cold shock
C4J65_RS18645	COG0459	protein refolding
C4J65_RS18685	COG1309	transcriptional regulator
C4J65_RS18690	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS18710	COG3903	Transcriptional regulator
C4J65_RS18710	COG3629	intracellular signal transduction
C4J65_RS18715	COG1595	DNA-templated transcription, initiation
C4J65_RS18730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4J65_RS18775	COG3973	AAA domain
C4J65_RS18785	COG1061	Type III restriction enzyme res subunit
C4J65_RS18825	COG1278	Cold shock
C4J65_RS18830	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C4J65_RS18835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4J65_RS18845	COG2814	Major facilitator Superfamily
C4J65_RS18860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4J65_RS18870	COG2252	PERMEase
C4J65_RS18895	COG0667	Aldo Keto reductase
C4J65_RS18945	COG2197	response regulator
C4J65_RS18995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4J65_RS19000	COG0277	FAD linked oxidase domain protein
C4J65_RS19000	COG0247	lactate metabolic process
C4J65_RS19020	COG2318	DinB family
C4J65_RS19035	COG0515	serine threonine protein kinase
C4J65_RS19035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J65_RS19050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J65_RS19065	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS19085	COG0259	pyridoxamine-phosphate oxidase activity
C4J65_RS19105	COG4821	SIS domain
C4J65_RS19115	COG0596	Alpha beta hydrolase
C4J65_RS19115	COG2945	thiolester hydrolase activity
C4J65_RS19125	COG1131	(ABC) transporter
C4J65_RS19165	COG1595	DNA-templated transcription, initiation
C4J65_RS19195	COG2271	Major facilitator Superfamily
C4J65_RS19200	COG2072	flavoprotein involved in K transport
C4J65_RS19225	COG1309	transcriptional regulator
C4J65_RS19235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J65_RS19235	COG0515	serine threonine protein kinase
C4J65_RS19250	COG3903	Transcriptional regulator
C4J65_RS19250	COG3629	intracellular signal transduction
C4J65_RS19265	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C4J65_RS19325	COG1686	Belongs to the peptidase S11 family
C4J65_RS19350	COG0386	Belongs to the glutathione peroxidase family
C4J65_RS19380	COG0477	Major facilitator Superfamily
C4J65_RS19385	COG4941	Belongs to the sigma-70 factor family
C4J65_RS19390	COG3795	YCII-related domain
C4J65_RS19420	COG4585	Histidine kinase
C4J65_RS19425	COG2197	response regulator
C4J65_RS19445	COG3226	Transcriptional regulator
C4J65_RS19450	COG0738	Major facilitator superfamily
C4J65_RS19460	COG0640	Transcriptional regulator
C4J65_RS19485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4J65_RS19490	COG0406	alpha-ribazole phosphatase activity
C4J65_RS19500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4J65_RS19505	COG0785	Cytochrome C biogenesis protein
C4J65_RS19510	COG1333	cytochrome c biogenesis protein
C4J65_RS19515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4J65_RS19550	COG0583	DNA-binding transcription factor activity
C4J65_RS19590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4J65_RS19595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4J65_RS19600	COG0163	prenyltransferase activity
C4J65_RS19610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C4J65_RS19615	COG1573	uracil-dna glycosylase
C4J65_RS19630	COG1301	dicarboxylic acid transport
C4J65_RS19650	COG0745	RESPONSE REGULATOR receiver
C4J65_RS19655	COG2205	protein histidine kinase activity
C4J65_RS19685	COG0183	Belongs to the thiolase family
C4J65_RS19695	COG1278	Cold shock
C4J65_RS19700	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C4J65_RS19715	COG1674	ftsk spoiiie
C4J65_RS19805	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C4J65_RS19910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C4J65_RS19925	COG2226	methyltransferase
C4J65_RS19945	COG0242	peptide deformylase activity
C4J65_RS19960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J65_RS19965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J65_RS19970	COG0649	NAD binding
C4J65_RS19980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4J65_RS19985	COG1034	ATP synthesis coupled electron transport
C4J65_RS19990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4J65_RS19995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J65_RS20000	COG0839	Belongs to the complex I subunit 6 family
C4J65_RS20005	COG0713	ATP synthesis coupled electron transport
C4J65_RS20010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J65_RS20020	COG1007	ATP synthesis coupled electron transport
C4J65_RS20035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4J65_RS20040	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4J65_RS20045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J65_RS20060	COG2188	Transcriptional regulator
C4J65_RS20075	COG0561	phosphatase activity
C4J65_RS20090	COG0142	geranyltranstransferase activity
C4J65_RS20100	COG1131	(ABC) transporter
C4J65_RS20135	COG0702	epimerase
C4J65_RS20140	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4J65_RS20145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4J65_RS20145	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4J65_RS20160	COG4585	Histidine kinase
C4J65_RS20165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J65_RS20170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J65_RS20175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J65_RS20180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4J65_RS20185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J65_RS20195	COG0713	ATP synthesis coupled electron transport
C4J65_RS20200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J65_RS20210	COG1007	ATP synthesis coupled electron transport
C4J65_RS20215	COG0501	Belongs to the peptidase M48B family
C4J65_RS20220	COG3304	Inner membrane component domain
C4J65_RS20235	COG2261	transglycosylase associated protein
C4J65_RS20240	COG1666	GTP binding
C4J65_RS20250	COG3903	Transcriptional regulator
C4J65_RS20250	COG3629	intracellular signal transduction
C4J65_RS20260	COG0702	epimerase
C4J65_RS20265	COG0402	S-adenosylhomocysteine deaminase activity
C4J65_RS20280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4J65_RS20285	COG2030	dehydratase
C4J65_RS20310	COG0477	Major facilitator Superfamily
C4J65_RS20320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4J65_RS20330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J65_RS20335	COG0436	Aminotransferase
C4J65_RS20345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4J65_RS20350	COG0250	Participates in transcription elongation, termination and antitermination
C4J65_RS20355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4J65_RS20360	COG0081	regulation of translation
C4J65_RS20375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4J65_RS20380	COG0222	ribosome binding
C4J65_RS20390	COG0085	RNA polymerase activity
C4J65_RS20395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4J65_RS20410	COG0463	Glycosyl transferase, family 2
C4J65_RS20415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4J65_RS20420	COG0049	tRNA binding
C4J65_RS20425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4J65_RS20430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4J65_RS20445	COG1136	(ABC) transporter
C4J65_RS20445	COG0577	efflux transmembrane transporter activity
C4J65_RS20455	COG2197	response regulator
C4J65_RS20530	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS20540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4J65_RS20590	COG0051	transcription antitermination factor activity, RNA binding
C4J65_RS20595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4J65_RS20600	COG0088	Forms part of the polypeptide exit tunnel
C4J65_RS20605	COG0089	rRNA binding
C4J65_RS20610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4J65_RS20615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4J65_RS20620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4J65_RS20625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4J65_RS20630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4J65_RS20635	COG0255	Belongs to the universal ribosomal protein uL29 family
C4J65_RS20640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4J65_RS20645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4J65_RS20650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4J65_RS20655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4J65_RS20660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4J65_RS20670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4J65_RS20675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4J65_RS20680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4J65_RS20685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4J65_RS20690	COG1841	ribosomal large subunit assembly
C4J65_RS20695	COG0200	Binds to the 23S rRNA
C4J65_RS20700	COG0201	protein transport
C4J65_RS20705	COG0563	adenylate kinase activity
C4J65_RS20715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4J65_RS20720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4J65_RS20725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4J65_RS20730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4J65_RS20735	COG0202	RNA polymerase activity
C4J65_RS20740	COG0203	ribosomal protein L17
C4J65_RS20745	COG0101	tRNA pseudouridine synthase activity
C4J65_RS20760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4J65_RS20765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4J65_RS20770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J65_RS20780	COG1072	(Pantothenic acid kinase))
C4J65_RS20790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J65_RS20810	COG0736	holo-[acyl-carrier-protein] synthase activity
C4J65_RS20815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4J65_RS20825	COG0802	atpase or kinase
C4J65_RS20840	COG0456	acetyltransferase
C4J65_RS20840	COG1214	PFAM Peptidase M22, glycoprotease
C4J65_RS20850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4J65_RS20875	COG4941	Belongs to the sigma-70 factor family
C4J65_RS20885	COG0726	polysaccharide deacetylase
C4J65_RS20890	COG0726	polysaccharide deacetylase
C4J65_RS20895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4J65_RS20900	COG0459	protein refolding
C4J65_RS20910	COG4221	oxidoreductase activity
C4J65_RS20920	COG0583	DNA-binding transcription factor activity
C4J65_RS20935	COG1595	DNA-templated transcription, initiation
C4J65_RS20945	COG0516	GMP reductase activity
C4J65_RS20965	COG0515	serine threonine protein kinase
C4J65_RS20965	COG2815	serine threonine protein kinase
C4J65_RS20970	COG0515	serine threonine protein kinase
C4J65_RS20975	COG2815	serine threonine protein kinase
C4J65_RS20975	COG0515	serine threonine protein kinase
C4J65_RS20980	COG0515	serine threonine protein kinase
C4J65_RS20985	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS21010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J65_RS21010	COG0519	Catalyzes the synthesis of GMP from XMP
C4J65_RS21050	COG2197	response regulator
C4J65_RS21065	COG0791	NLP P60 protein
C4J65_RS21090	COG0739	heme binding
C4J65_RS21100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS21100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS21115	COG0714	Associated with various cellular activities
C4J65_RS21120	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C4J65_RS21125	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C4J65_RS21140	COG0045	succinate-CoA ligase (ADP-forming) activity
C4J65_RS21170	COG0138	bifunctional purine biosynthesis protein purh
C4J65_RS21190	COG3409	Peptidoglycan-binding domain 1 protein
C4J65_RS21195	COG0515	serine threonine protein kinase
C4J65_RS21195	COG2815	serine threonine protein kinase
C4J65_RS21230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4J65_RS21245	COG0039	L-malate dehydrogenase activity
C4J65_RS21250	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS21260	COG0517	IMP dehydrogenase activity
C4J65_RS21260	COG4175	Glycine betaine
C4J65_RS21265	COG4176	ABC-type proline glycine betaine transport system permease component
C4J65_RS21280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J65_RS21285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J65_RS21290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J65_RS21295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J65_RS21305	COG0180	Tryptophanyl-tRNA synthetase
C4J65_RS21325	COG0671	phosphoesterase, PA-phosphatase related
C4J65_RS21345	COG1686	Belongs to the peptidase S11 family
C4J65_RS21355	COG1408	metallophosphoesterase
C4J65_RS21360	COG1309	transcriptional regulator
C4J65_RS21390	COG1053	succinate dehydrogenase
C4J65_RS21400	COG2009	succinate dehydrogenase
C4J65_RS21430	COG1595	DNA-templated transcription, initiation
C4J65_RS21440	COG1595	DNA-templated transcription, initiation
C4J65_RS21455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS21455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS21475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4J65_RS21495	COG1216	Glycosyl transferase, family 2
C4J65_RS21510	COG2089	acid synthase
C4J65_RS21520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4J65_RS21520	COG1473	amidohydrolase
C4J65_RS21525	COG1744	ABC transporter substrate-binding protein PnrA-like
C4J65_RS21530	COG1744	ABC transporter substrate-binding protein PnrA-like
C4J65_RS21540	COG3845	ABC transporter
C4J65_RS21550	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4J65_RS21585	COG2814	Major facilitator Superfamily
C4J65_RS21590	COG0583	DNA-binding transcription factor activity
C4J65_RS21610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J65_RS21635	COG2205	protein histidine kinase activity
C4J65_RS21640	COG0745	RESPONSE REGULATOR receiver
C4J65_RS21645	COG1595	DNA-templated transcription, initiation
C4J65_RS21660	COG0515	serine threonine protein kinase
C4J65_RS21665	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS21670	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS21685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J65_RS21715	COG4770	biotin carboxylase activity
C4J65_RS21725	COG0424	maF-like protein
C4J65_RS21740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J65_RS21750	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4J65_RS21760	COG1024	Enoyl-CoA hydratase
C4J65_RS21770	COG2986	histidine ammonia-lyase
C4J65_RS21790	COG1595	DNA-templated transcription, initiation
C4J65_RS21795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C4J65_RS21830	COG1064	alcohol dehydrogenase
C4J65_RS21835	COG1090	epimerase
C4J65_RS21845	COG1140	nitrate reductase beta subunit
C4J65_RS21860	COG0667	Aldo Keto reductase
C4J65_RS21870	COG1733	regulation of RNA biosynthetic process
C4J65_RS21885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J65_RS21905	COG1595	DNA-templated transcription, initiation
C4J65_RS21910	COG2255	four-way junction helicase activity
C4J65_RS21915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J65_RS21930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J65_RS21940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4J65_RS21965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J65_RS21975	COG0590	tRNA wobble adenosine to inosine editing
C4J65_RS21980	COG1331	Highly conserved protein containing a thioredoxin domain
C4J65_RS21995	COG1309	transcriptional regulator
C4J65_RS22005	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C4J65_RS22045	COG0436	Aminotransferase
C4J65_RS22055	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4J65_RS22070	COG1414	Transcriptional regulator
C4J65_RS22075	COG0251	oxidation-reduction process
C4J65_RS22080	COG2610	gluconate transmembrane transporter activity
C4J65_RS22135	COG2894	cell division
C4J65_RS22230	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS22245	COG2226	methyltransferase
C4J65_RS22260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4J65_RS22265	COG0741	lytic transglycosylase activity
C4J65_RS22275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J65_RS22280	COG0450	alkyl hydroperoxide reductase
C4J65_RS22295	COG1136	(ABC) transporter
C4J65_RS22315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J65_RS22315	COG4499	WXG100 protein secretion system (Wss), protein YukC
C4J65_RS22330	COG0114	fumarate hydratase activity
C4J65_RS22340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4J65_RS22340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4J65_RS22365	COG0778	Nitroreductase
C4J65_RS22400	COG1722	exodeoxyribonuclease VII activity
C4J65_RS22405	COG1570	exodeoxyribonuclease VII activity
C4J65_RS22415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4J65_RS22430	COG0012	GTP binding
C4J65_RS22445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J65_RS22460	COG2272	Belongs to the type-B carboxylesterase lipase family
C4J65_RS22470	COG2318	DinB family
C4J65_RS22485	COG0583	DNA-binding transcription factor activity
C4J65_RS22535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4J65_RS22540	COG1053	succinate dehydrogenase
C4J65_RS22565	COG1217	gtp-binding protein TYPA
C4J65_RS22580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J65_RS22595	COG0444	Belongs to the ABC transporter superfamily
C4J65_RS22600	COG4608	Belongs to the ABC transporter superfamily
C4J65_RS22610	COG0601	transmembrane transport
C4J65_RS22615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J65_RS22620	COG0444	Belongs to the ABC transporter superfamily
C4J65_RS22625	COG4608	Belongs to the ABC transporter superfamily
C4J65_RS22645	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C4J65_RS22655	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C4J65_RS22700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4J65_RS22750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J65_RS22760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4J65_RS22770	COG0519	Catalyzes the synthesis of GMP from XMP
C4J65_RS22775	COG1024	Enoyl-CoA hydratase
C4J65_RS22790	COG1595	DNA-templated transcription, initiation
C4J65_RS22800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J65_RS22805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J65_RS22830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4J65_RS22840	COG0598	Magnesium transport protein CorA
C4J65_RS22850	COG2814	Major facilitator Superfamily
C4J65_RS22865	COG2095	MarC family integral membrane protein
C4J65_RS22875	COG1432	Conserved Protein
C4J65_RS22880	COG2267	carboxylic ester hydrolase activity
C4J65_RS22885	COG0513	Belongs to the DEAD box helicase family
C4J65_RS22960	COG0596	Alpha beta hydrolase
C4J65_RS22985	COG0210	DNA helicase
C4J65_RS23010	COG2362	D-Aminopeptidase
C4J65_RS23040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4J65_RS23090	COG3480	Lon protease (S16) C-terminal proteolytic domain
C4J65_RS23100	COG1615	UPF0182 protein
C4J65_RS23130	COG0483	inositol monophosphate 1-phosphatase activity
C4J65_RS23140	COG2076	Multidrug Resistance protein
C4J65_RS23150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J65_RS23160	COG2135	peptidase activity
C4J65_RS23170	COG1595	DNA-templated transcription, initiation
C4J65_RS23175	COG5662	AntiSigma factor
C4J65_RS23195	COG0242	peptide deformylase activity
C4J65_RS23205	COG2124	cytochrome p450
C4J65_RS23245	COG2188	Transcriptional regulator
C4J65_RS23250	COG2182	Extracellular solute-binding protein
C4J65_RS23255	COG1175	transmembrane transport
C4J65_RS23260	COG0395	ABC-type sugar transport system, permease component
C4J65_RS23265	COG1472	Belongs to the glycosyl hydrolase 3 family
C4J65_RS23270	COG0363	glucosamine-6-phosphate deaminase activity
C4J65_RS23275	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS23295	COG1597	lipid kinase activity
C4J65_RS23335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J65_RS23340	COG0142	geranyltranstransferase activity
C4J65_RS23345	COG0456	acetyltransferase
C4J65_RS23375	COG4106	trans-aconitate 2-methyltransferase activity
C4J65_RS23380	COG1126	abc transporter atp-binding protein
C4J65_RS23395	COG0281	malic enzyme
C4J65_RS23400	COG0604	alcohol dehydrogenase
C4J65_RS23445	COG2255	four-way junction helicase activity
C4J65_RS23470	COG0567	Dehydrogenase, E1 component
C4J65_RS23470	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J65_RS23475	COG2205	protein histidine kinase activity
C4J65_RS23480	COG0745	RESPONSE REGULATOR receiver
C4J65_RS23490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J65_RS23535	COG0791	NLP P60 protein
C4J65_RS23535	COG3883	PFAM NLP P60 protein
C4J65_RS23545	COG1309	transcriptional regulator
C4J65_RS23575	COG2205	protein histidine kinase activity
C4J65_RS23595	COG3285	dna ligase
C4J65_RS23595	COG1793	dna ligase
C4J65_RS23600	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4J65_RS23610	COG1129	ABC transporter
C4J65_RS23615	COG1309	transcriptional regulator
C4J65_RS23630	COG3467	pyridoxamine 5'-phosphate
C4J65_RS23645	COG2867	negative regulation of translational initiation
C4J65_RS23650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS23655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS23660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS23665	COG0662	Cupin 2, conserved barrel domain protein
C4J65_RS23670	COG2329	Antibiotic biosynthesis monooxygenase
C4J65_RS23675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J65_RS23710	COG1683	Conserved Protein
C4J65_RS23715	COG4319	ketosteroid isomerase
C4J65_RS23720	COG1733	regulation of RNA biosynthetic process
C4J65_RS23780	COG2188	Transcriptional regulator
C4J65_RS23835	COG0745	RESPONSE REGULATOR receiver
C4J65_RS23840	COG0018	arginyl-trna synthetase
C4J65_RS23845	COG0019	diaminopimelate decarboxylase activity
C4J65_RS23850	COG0460	homoserine dehydrogenase
C4J65_RS23855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4J65_RS23860	COG0083	homoserine kinase activity
C4J65_RS23870	COG1316	TRANSCRIPTIONal
C4J65_RS23875	COG0254	rRNA binding
C4J65_RS23880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4J65_RS23885	COG2890	protein-(glutamine-N5) methyltransferase activity
C4J65_RS23895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4J65_RS23900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J65_RS23920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4J65_RS23925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4J65_RS23930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4J65_RS23935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4J65_RS23940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4J65_RS23945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4J65_RS23950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4J65_RS23965	COG2197	response regulator
C4J65_RS23970	COG4585	Histidine kinase
C4J65_RS24000	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS24015	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C4J65_RS24050	COG1131	(ABC) transporter
C4J65_RS24070	COG0183	Belongs to the thiolase family
C4J65_RS24090	COG0745	RESPONSE REGULATOR receiver
C4J65_RS24140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS24140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS24190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4J65_RS24195	COG0280	phosphate acetyltransferase
C4J65_RS24195	COG0857	belongs to the CobB CobQ family
C4J65_RS24200	COG0205	6-phosphofructokinase activity
C4J65_RS24210	COG0395	ABC-type sugar transport system, permease component
C4J65_RS24220	COG1653	transport
C4J65_RS24245	COG4565	transcriptional regulatory protein
C4J65_RS24250	COG3290	protein histidine kinase activity
C4J65_RS24255	COG1301	dicarboxylic acid transport
C4J65_RS24265	COG3118	belongs to the thioredoxin family
C4J65_RS24280	COG3281	Trehalose synthase
C4J65_RS24285	COG0366	Alpha amylase catalytic
C4J65_RS24290	COG0366	Alpha amylase catalytic
C4J65_RS24295	COG0058	SHG alpha-glucan phosphorylase activity
C4J65_RS24315	COG1132	(ABC) transporter
C4J65_RS24325	COG1132	(ABC) transporter
C4J65_RS24330	COG1132	(ABC) transporter
C4J65_RS24335	COG1131	(ABC) transporter
C4J65_RS24345	COG4585	Histidine kinase
C4J65_RS24350	COG2197	response regulator
C4J65_RS24365	COG1376	ErfK ybiS ycfS ynhG family protein
C4J65_RS24390	COG0789	Transcriptional regulator
C4J65_RS24400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J65_RS24405	COG3757	hydrolase, family 25
C4J65_RS24405	COG3409	Peptidoglycan-binding domain 1 protein
C4J65_RS24415	COG0667	Aldo Keto reductase
C4J65_RS24425	COG1760	l-serine dehydratase
C4J65_RS24430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J65_RS24435	COG0509	glycine decarboxylation via glycine cleavage system
C4J65_RS24440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J65_RS24460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J65_RS24465	COG4166	transmembrane transport
C4J65_RS24475	COG0444	Belongs to the ABC transporter superfamily
C4J65_RS24480	COG4608	Belongs to the ABC transporter superfamily
C4J65_RS24485	COG2860	membrane
C4J65_RS24495	COG1309	transcriptional regulator
C4J65_RS24520	COG0482	sulfurtransferase activity
C4J65_RS24535	COG1611	Belongs to the LOG family
C4J65_RS24540	COG4221	oxidoreductase activity
C4J65_RS24550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J65_RS24560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J65_RS24565	COG0154	amidase activity
C4J65_RS24575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J65_RS24580	COG2409	Drug exporters of the RND superfamily
C4J65_RS24585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J65_RS24600	COG2197	response regulator
C4J65_RS24610	COG2133	pyrroloquinoline quinone binding
C4J65_RS24615	COG0667	Aldo Keto reductase
C4J65_RS24625	COG5001	Diguanylate cyclase
C4J65_RS24635	COG0440	acetolactate synthase activity
C4J65_RS24640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4J65_RS24645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J65_RS24650	COG0477	Major facilitator Superfamily
C4J65_RS24660	COG2508	Transcriptional regulator
C4J65_RS24665	COG0506	proline dehydrogenase activity
C4J65_RS24670	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS24680	COG0473	3-isopropylmalate dehydrogenase activity
C4J65_RS24685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J65_RS24695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J65_RS24720	COG2353	YceI-like domain
C4J65_RS24725	COG5492	domain, Protein
C4J65_RS24730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J65_RS24750	COG2018	Roadblock/LC7 domain
C4J65_RS24770	COG2018	Roadblock/LC7 domain
C4J65_RS24775	COG5002	protein histidine kinase activity
C4J65_RS24785	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J65_RS24790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J65_RS24840	COG1414	Transcriptional regulator
C4J65_RS24845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J65_RS24850	COG0066	3-isopropylmalate dehydratase activity
C4J65_RS24860	COG0776	regulation of translation
C4J65_RS24870	COG1920	GTP binding
C4J65_RS24880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4J65_RS24885	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J65_RS24900	COG0351	phosphomethylpyrimidine kinase
C4J65_RS24910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4J65_RS24915	COG1461	Dihydroxyacetone kinase
C4J65_RS24925	COG0742	ribosomal rna small subunit methyltransferase
C4J65_RS24930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4J65_RS24945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4J65_RS24950	COG0571	ribonuclease III activity
C4J65_RS24955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J65_RS24960	COG1733	regulation of RNA biosynthetic process
C4J65_RS24970	COG1254	Belongs to the acylphosphatase family
C4J65_RS24980	COG1196	nuclear chromosome segregation
C4J65_RS24985	COG0477	Major facilitator Superfamily
C4J65_RS25020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4J65_RS25030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4J65_RS25050	COG0228	four-way junction DNA binding
C4J65_RS25055	COG1837	Belongs to the UPF0109 family
C4J65_RS25060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4J65_RS25065	COG0336	Belongs to the RNA methyltransferase TrmD family
C4J65_RS25070	COG0335	large ribosomal subunit rRNA binding
C4J65_RS25075	COG0681	Belongs to the peptidase S26 family
C4J65_RS25085	COG0681	Belongs to the peptidase S26 family
C4J65_RS25090	COG0681	Belongs to the peptidase S26 family
C4J65_RS25105	COG0792	nuclease activity
C4J65_RS25120	COG1191	sigma factor activity
C4J65_RS25135	COG0052	Belongs to the universal ribosomal protein uS2 family
C4J65_RS25140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4J65_RS25145	COG0528	UMP kinase activity
C4J65_RS25150	COG0233	cytoplasmic translational termination
C4J65_RS25155	COG0575	Belongs to the CDS family
C4J65_RS25160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4J65_RS25170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C4J65_RS25175	COG3842	ATPase activity
C4J65_RS25210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4J65_RS25220	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS25230	COG0584	glycerophosphoryl diester phosphodiesterase
C4J65_RS25235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J65_RS25265	COG3842	ATPase activity
C4J65_RS25270	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J65_RS25275	COG1177	transmembrane transport
C4J65_RS25280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J65_RS25315	COG2508	Transcriptional regulator
C4J65_RS25315	COG2508	Transcriptional regulator
C4J65_RS25320	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS25345	COG4209	transmembrane transport
C4J65_RS25350	COG0395	ABC-type sugar transport system, permease component
C4J65_RS25380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4J65_RS25385	COG0750	zinc metalloprotease
C4J65_RS25390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4J65_RS25405	COG0442	prolyl-tRNA aminoacylation
C4J65_RS25430	COG0779	Required for maturation of 30S ribosomal subunits
C4J65_RS25445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4J65_RS25455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4J65_RS25460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4J65_RS25475	COG4608	Belongs to the ABC transporter superfamily
C4J65_RS25490	COG0601	transmembrane transport
C4J65_RS25495	COG0747	negative chemotaxis
C4J65_RS25500	COG0455	bacterial-type flagellum organization
C4J65_RS25515	COG3266	domain, Protein
C4J65_RS25555	COG1404	Belongs to the peptidase S8 family
C4J65_RS25570	COG1674	ftsk spoiiie
C4J65_RS25585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4J65_RS25590	COG1185	polyribonucleotide nucleotidyltransferase activity
C4J65_RS25595	COG0612	Peptidase, M16
C4J65_RS25600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4J65_RS25620	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C4J65_RS25625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J65_RS25630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C4J65_RS25665	COG2770	Histidine kinase
C4J65_RS25665	COG2208	phosphoserine phosphatase activity
C4J65_RS25675	COG2205	protein histidine kinase activity
C4J65_RS25675	COG0784	Response regulator, receiver
C4J65_RS25685	COG1674	ftsk spoiiie
C4J65_RS25695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J65_RS25705	COG1058	Belongs to the CinA family
C4J65_RS25705	COG1546	Belongs to the CinA family
C4J65_RS25710	COG1396	sequence-specific DNA binding
C4J65_RS25715	COG0783	Belongs to the Dps family
C4J65_RS25725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4J65_RS25735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J65_RS25740	COG1201	RNA secondary structure unwinding
C4J65_RS25745	COG2207	Transcriptional regulator
C4J65_RS25745	COG1917	Cupin 2, conserved barrel domain protein
C4J65_RS25770	COG0628	permease
C4J65_RS25785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4J65_RS25795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J65_RS25810	COG0765	amino acid transport
C4J65_RS25815	COG0765	amino acid transport
C4J65_RS25820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J65_RS25825	COG1126	abc transporter atp-binding protein
C4J65_RS25830	COG0745	RESPONSE REGULATOR receiver
C4J65_RS25835	COG2205	protein histidine kinase activity
C4J65_RS25860	COG3851	Histidine kinase
C4J65_RS25865	COG2197	response regulator
C4J65_RS25870	COG4733	cellulase activity
C4J65_RS25870	COG5297	Belongs to the glycosyl hydrolase family 6
C4J65_RS25875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J65_RS25895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4J65_RS25905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J65_RS25910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J65_RS25920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4J65_RS25955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4J65_RS25960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4J65_RS25965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J65_RS25980	COG0588	phosphoglycerate mutase activity
C4J65_RS26000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4J65_RS26035	COG2186	Transcriptional regulator
C4J65_RS26040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J65_RS26055	COG0187	DNA topoisomerase II activity
C4J65_RS26070	COG2197	response regulator
C4J65_RS26080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J65_RS26085	COG4565	transcriptional regulatory protein
C4J65_RS26090	COG3290	protein histidine kinase activity
C4J65_RS26105	COG0372	Belongs to the citrate synthase family
C4J65_RS26125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4J65_RS26130	COG0612	Peptidase, M16
C4J65_RS26145	COG1802	Transcriptional regulator
C4J65_RS26150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J65_RS26175	COG1435	thymidine kinase activity
C4J65_RS26195	COG2222	sugar isomerase
C4J65_RS26250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4J65_RS26265	COG0745	RESPONSE REGULATOR receiver
C4J65_RS26270	COG2205	protein histidine kinase activity
C4J65_RS26295	COG0756	dUTP diphosphatase activity
C4J65_RS26305	COG1136	(ABC) transporter
C4J65_RS26305	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J65_RS26335	COG0569	domain protein
C4J65_RS26340	COG0531	amino acid
C4J65_RS26345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J65_RS26505	COG3654	unkown
C4J65_RS26565	COG0300	oxidoreductase activity
C4J65_RS26585	COG2182	Extracellular solute-binding protein
C4J65_RS26595	COG3833	ABC-type maltose transport systems, permease component
C4J65_RS26625	COG1959	2 iron, 2 sulfur cluster binding
C4J65_RS26640	COG5002	protein histidine kinase activity
C4J65_RS26660	COG1136	(ABC) transporter
C4J65_RS26660	COG0577	efflux transmembrane transporter activity
C4J65_RS26665	COG1136	(ABC) transporter
C4J65_RS26665	COG0577	efflux transmembrane transporter activity
C4J65_RS26695	COG0443	Heat shock 70 kDa protein
C4J65_RS26720	COG3693	PFAM glycoside hydrolase, family 10
C4J65_RS26745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J65_RS26745	COG0574	Belongs to the PEP-utilizing enzyme family
C4J65_RS26765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J65_RS26785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J65_RS26790	COG0436	Aminotransferase
C4J65_RS26810	COG0405	Gamma-glutamyltransferase
C4J65_RS26815	COG3619	membrane
C4J65_RS26855	COG0745	RESPONSE REGULATOR receiver
C4J65_RS26860	COG2205	protein histidine kinase activity
C4J65_RS26880	COG2319	Wd-40 repeat
C4J65_RS26900	COG0477	Major facilitator Superfamily
C4J65_RS26905	COG1122	ATPase activity
C4J65_RS26915	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C4J65_RS26920	COG0310	cobalt ion transport
C4J65_RS26930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J65_RS26945	COG0277	FAD linked oxidase domain protein
C4J65_RS26945	COG0247	lactate metabolic process
C4J65_RS26950	COG1799	cell septum assembly
C4J65_RS26980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J65_RS26990	COG2235	arginine
C4J65_RS26995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4J65_RS27000	COG0531	amino acid
C4J65_RS27010	COG1024	Enoyl-CoA hydratase
C4J65_RS27030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J65_RS27110	COG0681	Belongs to the peptidase S26 family
C4J65_RS27205	COG0681	Belongs to the peptidase S26 family
C4J65_RS27215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4J65_RS27220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4J65_RS27230	COG4209	transmembrane transport
C4J65_RS27235	COG0395	ABC-type sugar transport system, permease component
C4J65_RS27265	COG1653	transport
C4J65_RS27270	COG1175	transmembrane transport
C4J65_RS27275	COG0395	ABC-type sugar transport system, permease component
C4J65_RS27280	COG1940	carbohydrate kinase activity
C4J65_RS27285	COG4213	ABC transporter substrate-binding protein
C4J65_RS27295	COG4214	carbohydrate transport
C4J65_RS27300	COG3979	chitinase
C4J65_RS27310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4J65_RS27315	COG0531	amino acid
C4J65_RS27330	COG1316	TRANSCRIPTIONal
C4J65_RS27355	COG2089	acid synthase
C4J65_RS27370	COG1024	Enoyl-CoA hydratase
C4J65_RS27370	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS27375	COG0183	Belongs to the thiolase family
C4J65_RS27380	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C4J65_RS27395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4J65_RS27400	COG1472	Belongs to the glycosyl hydrolase 3 family
C4J65_RS27440	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J65_RS27450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C4J65_RS27455	COG3253	May function as heme-dependent peroxidase
C4J65_RS27470	COG3220	belongs to the UPF0276 family
C4J65_RS27480	COG1116	anion transmembrane transporter activity
C4J65_RS27500	COG0723	plastoquinol--plastocyanin reductase activity
C4J65_RS27500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J65_RS27510	COG0330	HflC and HflK could
C4J65_RS27545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J65_RS27550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J65_RS27560	COG3629	intracellular signal transduction
C4J65_RS27560	COG3903	Transcriptional regulator
C4J65_RS27575	COG3629	intracellular signal transduction
C4J65_RS27575	COG3903	Transcriptional regulator
C4J65_RS27585	COG1174	glycine betaine transport
C4J65_RS27590	COG1174	glycine betaine transport
C4J65_RS27595	COG1732	Glycine betaine
C4J65_RS27625	COG1309	transcriptional regulator
C4J65_RS27640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J65_RS27645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J65_RS27655	COG3173	Aminoglycoside phosphotransferase
C4J65_RS27665	COG1716	ATPase activity
C4J65_RS27715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4J65_RS27725	COG2409	Drug exporters of the RND superfamily
C4J65_RS27740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J65_RS27745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J65_RS27745	COG1116	anion transmembrane transporter activity
C4J65_RS27770	COG0529	Catalyzes the synthesis of activated sulfate
C4J65_RS27775	COG0175	sulfate reduction
C4J65_RS27785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J65_RS27805	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS27815	COG1940	carbohydrate kinase activity
C4J65_RS27840	COG1846	Transcriptional regulator
C4J65_RS27840	COG1940	carbohydrate kinase activity
C4J65_RS27850	COG3142	Participates in the control of copper homeostasis
C4J65_RS27855	COG4977	sequence-specific DNA binding
C4J65_RS27855	COG1917	Cupin 2, conserved barrel domain protein
C4J65_RS27920	COG2027	D-alanyl-D-alanine carboxypeptidase
C4J65_RS27935	COG0714	Associated with various cellular activities
C4J65_RS27950	COG2040	homocysteine
C4J65_RS27965	COG2197	response regulator
C4J65_RS27995	COG0277	FAD linked oxidase domain protein
C4J65_RS28005	COG1162	GTPase activity
C4J65_RS28015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J65_RS28035	COG0028	Belongs to the TPP enzyme family
C4J65_RS28055	COG1802	Transcriptional regulator
C4J65_RS28060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4J65_RS28070	COG2197	response regulator
C4J65_RS28075	COG3851	Histidine kinase
C4J65_RS28110	COG3835	regulator
C4J65_RS28130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J65_RS28135	COG2252	PERMEase
C4J65_RS28155	COG1595	DNA-templated transcription, initiation
C4J65_RS28175	COG0726	polysaccharide deacetylase
C4J65_RS28190	COG0438	transferase activity, transferring glycosyl groups
C4J65_RS28205	COG4249	Peptidase C14 caspase catalytic subunit p20
C4J65_RS28205	COG2319	Wd-40 repeat
C4J65_RS28220	COG2197	response regulator
C4J65_RS28225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J65_RS28230	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS28240	COG3960	tartronate-semialdehyde synthase activity
C4J65_RS28255	COG0753	catalase activity
C4J65_RS28260	COG2084	Dehydrogenase
C4J65_RS28265	COG3622	Belongs to the hyi family
C4J65_RS28285	COG2351	hydroxyisourate hydrolase activity
C4J65_RS28300	COG2233	PERMEase
C4J65_RS28310	COG1733	regulation of RNA biosynthetic process
C4J65_RS28325	COG0406	alpha-ribazole phosphatase activity
C4J65_RS28330	COG0436	Aminotransferase
C4J65_RS28350	COG4264	IucA IucC family
C4J65_RS28375	COG0583	DNA-binding transcription factor activity
C4J65_RS28390	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS28390	COG3321	synthase
C4J65_RS28390	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS28390	COG0300	oxidoreductase activity
C4J65_RS28390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J65_RS28400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J65_RS28415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4J65_RS28430	COG1414	Transcriptional regulator
C4J65_RS28435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J65_RS28440	COG4266	Belongs to the allantoicase family
C4J65_RS28445	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS28490	COG3766	membrane
C4J65_RS28495	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4J65_RS28510	COG2188	Transcriptional regulator
C4J65_RS28530	COG1940	carbohydrate kinase activity
C4J65_RS28540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J65_RS28550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J65_RS28555	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J65_RS28555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J65_RS28565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J65_RS28570	COG3938	Belongs to the proline racemase family
C4J65_RS28575	COG3291	Pkd domain containing protein
C4J65_RS28580	COG1802	Transcriptional regulator
C4J65_RS28585	COG0006	proline dipeptidase activity
C4J65_RS28605	COG1132	(ABC) transporter
C4J65_RS28615	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS28620	COG3246	L-lysine catabolic process to acetate
C4J65_RS28630	COG1472	Belongs to the glycosyl hydrolase 3 family
C4J65_RS28635	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J65_RS28650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J65_RS28680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J65_RS28700	COG1846	Transcriptional regulator
C4J65_RS28720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J65_RS28745	COG0154	amidase activity
C4J65_RS28755	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS28760	COG0475	glutathione-regulated potassium exporter activity
C4J65_RS28780	COG2986	histidine ammonia-lyase
C4J65_RS28785	COG2205	protein histidine kinase activity
C4J65_RS28790	COG0745	RESPONSE REGULATOR receiver
C4J65_RS28815	COG1609	Transcriptional regulator
C4J65_RS28865	COG0405	Gamma-glutamyltransferase
C4J65_RS28870	COG0542	response to heat
C4J65_RS28890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J65_RS28905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J65_RS28915	COG1953	Uracil, thiamine, allantoin
C4J65_RS28940	COG2197	response regulator
C4J65_RS28950	COG4585	Histidine kinase
C4J65_RS28965	COG2308	Evidence 4 Homologs of previously reported genes of
C4J65_RS28965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4J65_RS28970	COG0738	Major facilitator superfamily
C4J65_RS28990	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C4J65_RS29000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J65_RS29010	COG0019	diaminopimelate decarboxylase activity
C4J65_RS29025	COG3547	Transposase (IS116 IS110 IS902 family)
C4J65_RS29030	COG0477	Major facilitator Superfamily
C4J65_RS29050	COG2197	response regulator
C4J65_RS29055	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS29105	COG0501	Belongs to the peptidase M48B family
C4J65_RS29115	COG2072	flavoprotein involved in K transport
C4J65_RS29120	COG2890	protein-(glutamine-N5) methyltransferase activity
C4J65_RS29125	COG2124	cytochrome p450
C4J65_RS29135	COG0644	oxidoreductase
C4J65_RS29140	COG2124	cytochrome p450
C4J65_RS29145	COG0644	oxidoreductase
C4J65_RS29160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS29165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J65_RS29200	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS29210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS29215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J65_RS29220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J65_RS29225	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS29235	COG2267	carboxylic ester hydrolase activity
C4J65_RS29240	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS29240	COG1024	Enoyl-CoA hydratase
C4J65_RS29265	COG0483	inositol monophosphate 1-phosphatase activity
C4J65_RS29275	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J65_RS29290	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C4J65_RS29320	COG0640	Transcriptional regulator
C4J65_RS29335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J65_RS29345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4J65_RS29350	COG0494	nUDIX hydrolase
C4J65_RS29355	COG1929	Belongs to the glycerate kinase type-1 family
C4J65_RS29370	COG0688	phosphatidylethanolamine metabolic process
C4J65_RS29375	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS29385	COG2301	Belongs to the HpcH HpaI aldolase family
C4J65_RS29390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS29390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4J65_RS29395	COG0604	alcohol dehydrogenase
C4J65_RS29405	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS29425	COG0596	Alpha beta hydrolase
C4J65_RS29450	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J65_RS29450	COG2208	phosphoserine phosphatase activity
C4J65_RS29450	COG2172	sigma factor antagonist activity
C4J65_RS29470	COG2362	D-Aminopeptidase
C4J65_RS29475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J65_RS29485	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4J65_RS29515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS29530	COG1793	dna ligase
C4J65_RS29530	COG3285	dna ligase
C4J65_RS29595	COG1597	lipid kinase activity
C4J65_RS29600	COG0488	(ABC) transporter
C4J65_RS29615	COG0693	protein deglycase activity
C4J65_RS29625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J65_RS29685	COG0531	amino acid
C4J65_RS29710	COG1595	DNA-templated transcription, initiation
C4J65_RS29730	COG1140	nitrate reductase beta subunit
C4J65_RS29760	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4J65_RS29770	COG3401	FG-GAP repeat protein
C4J65_RS29785	COG5297	Belongs to the glycosyl hydrolase family 6
C4J65_RS29785	COG4733	cellulase activity
C4J65_RS29795	COG5297	Belongs to the glycosyl hydrolase family 6
C4J65_RS29805	COG4221	oxidoreductase activity
C4J65_RS29810	COG0656	L-ascorbic acid biosynthetic process
C4J65_RS29820	COG0477	Major facilitator Superfamily
C4J65_RS29845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4J65_RS29855	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4J65_RS29860	COG3383	formate dehydrogenase (NAD+) activity
C4J65_RS29865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4J65_RS29875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4J65_RS29890	COG1129	ABC transporter
C4J65_RS29895	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J65_RS29905	COG0673	inositol 2-dehydrogenase activity
C4J65_RS29960	COG2223	nitrite transmembrane transporter activity
C4J65_RS29970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J65_RS29980	COG0045	succinate-CoA ligase (ADP-forming) activity
C4J65_RS29990	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS30005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4J65_RS30045	COG2182	Extracellular solute-binding protein
C4J65_RS30050	COG1175	transmembrane transport
C4J65_RS30055	COG0395	ABC-type sugar transport system, permease component
C4J65_RS30060	COG2723	6-phospho-beta-galactosidase activity
C4J65_RS30080	COG4632	Exopolysaccharide biosynthesis protein
C4J65_RS30080	COG5434	Belongs to the glycosyl hydrolase 28 family
C4J65_RS30095	COG1733	regulation of RNA biosynthetic process
C4J65_RS30145	COG0300	oxidoreductase activity
C4J65_RS30165	COG0210	DNA helicase
C4J65_RS30175	COG1401	restriction endodeoxyribonuclease activity
C4J65_RS30270	COG0747	negative chemotaxis
C4J65_RS30305	COG0297	glycogen (starch) synthase activity
C4J65_RS30325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J65_RS30340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4J65_RS30345	COG0166	Belongs to the GPI family
C4J65_RS30360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J65_RS30380	COG2409	Drug exporters of the RND superfamily
C4J65_RS30385	COG2197	response regulator
C4J65_RS30390	COG4585	Histidine kinase
C4J65_RS30400	COG1486	melibiose metabolic process
C4J65_RS30410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J65_RS30440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J65_RS30445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J65_RS30480	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C4J65_RS30490	COG0477	Major facilitator Superfamily
C4J65_RS30495	COG3511	phospholipase C
C4J65_RS30525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J65_RS30530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4J65_RS30535	COG3485	protocatechuate 3,4-dioxygenase
C4J65_RS30540	COG3485	protocatechuate 3,4-dioxygenase
C4J65_RS30545	COG0183	Belongs to the thiolase family
C4J65_RS30565	COG1470	cell adhesion involved in biofilm formation
C4J65_RS30575	COG1793	dna ligase
C4J65_RS30625	COG1834	amidinotransferase
C4J65_RS30630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J65_RS30635	COG0488	(ABC) transporter
C4J65_RS30665	COG1515	deoxyribonuclease V activity
C4J65_RS30680	COG3268	Saccharopine dehydrogenase
C4J65_RS30685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J65_RS30690	COG0183	Belongs to the thiolase family
C4J65_RS30695	COG1024	Enoyl-CoA hydratase
C4J65_RS30695	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J65_RS30705	COG1113	amino acid transport
C4J65_RS30730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J65_RS30745	COG0488	(ABC) transporter
C4J65_RS30750	COG2183	response to ionizing radiation
C4J65_RS30765	COG4977	sequence-specific DNA binding
C4J65_RS30775	COG1024	Enoyl-CoA hydratase
C4J65_RS30785	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4J65_RS30830	COG1134	teichoic acid transport
C4J65_RS30835	COG1562	ergosterol biosynthetic process
C4J65_RS30850	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C4J65_RS30860	COG1657	PFAM Prenyltransferase squalene oxidase
C4J65_RS30875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4J65_RS30880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4J65_RS30900	COG2365	Tyrosine phosphatase family
C4J65_RS30910	COG2755	lipolytic protein G-D-S-L family
C4J65_RS30930	COG1408	metallophosphoesterase
C4J65_RS30940	COG3629	intracellular signal transduction
C4J65_RS30940	COG3903	Transcriptional regulator
C4J65_RS30960	COG1335	isochorismatase
C4J65_RS30975	COG2066	Belongs to the glutaminase family
C4J65_RS31010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J65_RS31035	COG0300	oxidoreductase activity
C4J65_RS31065	COG2814	Major facilitator Superfamily
C4J65_RS31070	COG0583	DNA-binding transcription factor activity
C4J65_RS31105	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J65_RS31110	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J65_RS31130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J65_RS31135	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS31170	COG1063	alcohol dehydrogenase
C4J65_RS31175	COG0156	8-amino-7-oxononanoate synthase activity
C4J65_RS31180	COG0583	DNA-binding transcription factor activity
C4J65_RS31210	COG2111	Na H antiporter
C4J65_RS31210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J65_RS31215	COG1006	Multisubunit Na H antiporter MnhC subunit
C4J65_RS31220	COG0651	ATP synthesis coupled electron transport
C4J65_RS31235	COG1320	monovalent cation:proton antiporter activity
C4J65_RS31250	COG0174	glutamine synthetase
C4J65_RS31275	COG2267	carboxylic ester hydrolase activity
C4J65_RS31280	COG0183	Belongs to the thiolase family
C4J65_RS31285	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS31315	COG2188	Transcriptional regulator
C4J65_RS31320	COG3962	Belongs to the TPP enzyme family
C4J65_RS31325	COG3718	enzyme involved in inositol metabolism
C4J65_RS31335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J65_RS31360	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C4J65_RS31365	COG0673	inositol 2-dehydrogenase activity
C4J65_RS31375	COG1609	Transcriptional regulator
C4J65_RS31380	COG0673	inositol 2-dehydrogenase activity
C4J65_RS31385	COG2186	Transcriptional regulator
C4J65_RS31395	COG0385	Bile acid
C4J65_RS31445	COG2124	cytochrome p450
C4J65_RS31460	COG2838	Isocitrate dehydrogenase
C4J65_RS31465	COG0668	transmembrane transport
C4J65_RS31470	COG0531	amino acid
C4J65_RS31480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J65_RS31500	COG1132	(ABC) transporter
C4J65_RS31510	COG0366	Alpha amylase catalytic
C4J65_RS31515	COG0395	ABC-type sugar transport system, permease component
C4J65_RS31520	COG1175	transmembrane transport
C4J65_RS31525	COG1653	transport
C4J65_RS31575	COG0515	serine threonine protein kinase
C4J65_RS31575	COG2815	serine threonine protein kinase
C4J65_RS31580	COG0515	serine threonine protein kinase
C4J65_RS31585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J65_RS31695	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J65_RS31695	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J65_RS31700	COG0210	DNA helicase
C4J65_RS31720	COG1874	Beta-galactosidase
C4J65_RS31720	COG0366	Alpha amylase catalytic
C4J65_RS31770	COG1175	transmembrane transport
C4J65_RS31780	COG1472	Belongs to the glycosyl hydrolase 3 family
C4J65_RS31795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J65_RS31805	COG0137	argininosuccinate synthase activity
C4J65_RS31830	COG0444	Belongs to the ABC transporter superfamily
C4J65_RS31840	COG0747	negative chemotaxis
C4J65_RS31850	COG3458	cephalosporin-C deacetylase activity
C4J65_RS31870	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4J65_RS31890	COG0640	Transcriptional regulator
C4J65_RS31895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4J65_RS31900	COG1993	acr, cog1993
C4J65_RS31905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4J65_RS31910	COG1968	undecaprenyl-diphosphatase activity
C4J65_RS31920	COG2066	Belongs to the glutaminase family
C4J65_RS31925	COG1686	Belongs to the peptidase S11 family
C4J65_RS31930	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4J65_RS31940	COG1695	Transcriptional regulator
C4J65_RS31945	COG2226	methyltransferase
C4J65_RS31950	COG2188	Transcriptional regulator
C4J65_RS31955	COG3458	cephalosporin-C deacetylase activity
C4J65_RS31970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J65_RS31980	COG2890	protein-(glutamine-N5) methyltransferase activity
C4J65_RS32000	COG1902	pentaerythritol trinitrate reductase activity
C4J65_RS32000	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J65_RS32030	COG1461	Dihydroxyacetone kinase
C4J65_RS32035	COG2376	Dihydroxyacetone kinase
C4J65_RS32060	COG2814	Major facilitator Superfamily
C4J65_RS32065	COG1959	2 iron, 2 sulfur cluster binding
C4J65_RS32070	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS32135	COG0745	RESPONSE REGULATOR receiver
C4J65_RS32140	COG2205	protein histidine kinase activity
C4J65_RS32155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J65_RS32165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4J65_RS32185	COG0515	serine threonine protein kinase
C4J65_RS32195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J65_RS32200	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS32250	COG0673	inositol 2-dehydrogenase activity
C4J65_RS32290	COG0431	NADPH-dependent FMN reductase
C4J65_RS32300	COG0667	Aldo Keto reductase
C4J65_RS32305	COG0346	lactoylglutathione lyase activity
C4J65_RS32310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J65_RS32320	COG0583	DNA-binding transcription factor activity
C4J65_RS32325	COG0667	Aldo Keto reductase
C4J65_RS32360	COG1191	sigma factor activity
C4J65_RS32365	COG1396	sequence-specific DNA binding
C4J65_RS32370	COG0740	serine-type endopeptidase activity
C4J65_RS32375	COG0740	serine-type endopeptidase activity
C4J65_RS32390	COG0328	RNA-DNA hybrid ribonuclease activity
C4J65_RS32400	COG0667	Aldo Keto reductase
C4J65_RS32420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J65_RS32430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J65_RS32440	COG2340	Cysteine-rich secretory protein family
C4J65_RS32445	COG2197	response regulator
C4J65_RS32475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J65_RS32505	COG0583	DNA-binding transcription factor activity
C4J65_RS32525	COG1982	Orn Lys Arg decarboxylase major
C4J65_RS32560	COG1252	NADH dehydrogenase
C4J65_RS32575	COG2172	sigma factor antagonist activity
C4J65_RS32580	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J65_RS32585	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J65_RS32600	COG0784	Response regulator, receiver
C4J65_RS32600	COG2205	protein histidine kinase activity
C4J65_RS32600	COG5002	protein histidine kinase activity
C4J65_RS32620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4J65_RS32625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J65_RS32640	COG0366	Alpha amylase catalytic
C4J65_RS32680	COG0181	hydroxymethylbilane synthase activity
C4J65_RS32690	COG1793	dna ligase
C4J65_RS32690	COG3285	dna ligase
C4J65_RS32695	COG0477	Major facilitator Superfamily
C4J65_RS32705	COG2223	nitrite transmembrane transporter activity
C4J65_RS32710	COG2207	Transcriptional regulator
C4J65_RS32725	COG2208	phosphoserine phosphatase activity
C4J65_RS32735	COG0656	L-ascorbic acid biosynthetic process
C4J65_RS32755	COG0009	L-threonylcarbamoyladenylate synthase
C4J65_RS32790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4J65_RS32805	COG0243	molybdopterin cofactor binding
C4J65_RS32810	COG0456	acetyltransferase
C4J65_RS32855	COG0475	glutathione-regulated potassium exporter activity
C4J65_RS32880	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS32925	COG1120	ATPase activity
C4J65_RS32945	COG0110	maltose O-acetyltransferase activity
C4J65_RS32965	COG0395	ABC-type sugar transport system, permease component
C4J65_RS32970	COG4209	transmembrane transport
C4J65_RS32975	COG1609	Transcriptional regulator
C4J65_RS32980	COG0028	Belongs to the TPP enzyme family
C4J65_RS32985	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS32995	COG4948	Mandelate Racemase Muconate Lactonizing
C4J65_RS33045	COG2814	Major facilitator Superfamily
C4J65_RS33050	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS33065	COG1959	2 iron, 2 sulfur cluster binding
C4J65_RS33085	COG5640	endopeptidase activity
C4J65_RS33090	COG0583	DNA-binding transcription factor activity
C4J65_RS33100	COG2814	Major facilitator Superfamily
C4J65_RS33115	COG0583	DNA-binding transcription factor activity
C4J65_RS33120	COG3340	Belongs to the peptidase S51 family
C4J65_RS33145	COG2124	cytochrome p450
C4J65_RS33195	COG1335	isochorismatase
C4J65_RS33205	COG2188	Transcriptional regulator
C4J65_RS33210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J65_RS33225	COG1119	ATPase activity
C4J65_RS33235	COG5640	endopeptidase activity
C4J65_RS33285	COG2050	protein possibly involved in aromatic compounds catabolism
C4J65_RS33290	COG3396	Phenylacetate-CoA oxygenase
C4J65_RS33295	COG3460	Phenylacetate-CoA oxygenase
C4J65_RS33300	COG3396	Phenylacetate-CoA oxygenase
C4J65_RS33305	COG2151	metal-sulfur cluster biosynthetic enzyme
C4J65_RS33310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J65_RS33370	COG0395	ABC-type sugar transport system, permease component
C4J65_RS33385	COG1063	alcohol dehydrogenase
C4J65_RS33390	COG1082	Xylose isomerase domain protein TIM barrel
C4J65_RS33395	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C4J65_RS33435	COG1953	Uracil, thiamine, allantoin
C4J65_RS33440	COG3940	Belongs to the glycosyl hydrolase 43 family
C4J65_RS33455	COG1175	transmembrane transport
C4J65_RS33460	COG0395	ABC-type sugar transport system, permease component
C4J65_RS33470	COG2175	clavaminate synthase activity
C4J65_RS33495	COG4977	sequence-specific DNA binding
C4J65_RS33500	COG2755	lipolytic protein G-D-S-L family
C4J65_RS33505	COG0326	Molecular chaperone. Has ATPase activity
C4J65_RS33510	COG2391	methyltransferase activity
C4J65_RS33515	COG3226	Transcriptional regulator
C4J65_RS33535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J65_RS33540	COG0542	response to heat
C4J65_RS33580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4J65_RS33580	COG2755	lipolytic protein G-D-S-L family
C4J65_RS33590	COG0745	RESPONSE REGULATOR receiver
C4J65_RS33595	COG2205	protein histidine kinase activity
C4J65_RS33605	COG2409	Drug exporters of the RND superfamily
C4J65_RS33610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J65_RS33625	COG2409	Drug exporters of the RND superfamily
C4J65_RS33630	COG0517	IMP dehydrogenase activity
C4J65_RS33630	COG0516	GMP reductase activity
C4J65_RS33665	COG3119	arylsulfatase activity
C4J65_RS33670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4J65_RS33685	COG3547	Transposase (IS116 IS110 IS902 family)
C4J65_RS33695	COG0604	alcohol dehydrogenase
C4J65_RS33720	COG0395	ABC-type sugar transport system, permease component
C4J65_RS33740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J65_RS33750	COG4533	DNA binding
C4J65_RS33755	COG0601	transmembrane transport
C4J65_RS33760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J65_RS33765	COG0444	Belongs to the ABC transporter superfamily
C4J65_RS33770	COG4608	Belongs to the ABC transporter superfamily
C4J65_RS33795	COG0277	FAD linked oxidase domain protein
C4J65_RS33815	COG0667	Aldo Keto reductase
C4J65_RS33865	COG5297	Belongs to the glycosyl hydrolase family 6
C4J65_RS33865	COG3250	beta-galactosidase activity
C4J65_RS33880	COG1902	pentaerythritol trinitrate reductase activity
C4J65_RS33920	COG0667	Aldo Keto reductase
C4J65_RS33925	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4J65_RS33930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J65_RS33945	COG1737	Transcriptional regulator
C4J65_RS33950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J65_RS34000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J65_RS34030	COG2045	Belongs to the ComB family
C4J65_RS34035	COG2353	YceI-like domain
C4J65_RS34085	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C4J65_RS34090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4J65_RS34115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J65_RS34130	COG4948	Mandelate Racemase Muconate Lactonizing
C4J65_RS34135	COG0406	alpha-ribazole phosphatase activity
C4J65_RS34145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4J65_RS34180	COG1309	transcriptional regulator
C4J65_RS34185	COG0148	phosphopyruvate hydratase activity
C4J65_RS34215	COG4709	membrane
C4J65_RS34240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J65_RS34250	COG0667	Aldo Keto reductase
C4J65_RS34255	COG4989	oxidoreductase activity
C4J65_RS34275	COG2130	NADP-dependent
C4J65_RS34300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J65_RS34305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C4J65_RS34330	COG0604	alcohol dehydrogenase
C4J65_RS34345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4J65_RS34355	COG0302	gtp cyclohydrolase
C4J65_RS34375	COG0659	secondary active sulfate transmembrane transporter activity
C4J65_RS34385	COG1755	Isoprenylcysteine carboxyl methyltransferase
C4J65_RS34430	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS34445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J65_RS34450	COG0765	amino acid transport
C4J65_RS34490	COG2936	dipeptidyl-peptidase activity
C4J65_RS34500	COG0747	negative chemotaxis
C4J65_RS34505	COG0601	transmembrane transport
C4J65_RS34515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J65_RS34520	COG1021	2,3-dihydroxybenzoate-AMP ligase
C4J65_RS34525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J65_RS34525	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4J65_RS34530	COG3433	isochorismatase activity
C4J65_RS34530	COG2226	methyltransferase
C4J65_RS34530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J65_RS34550	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4J65_RS34560	COG1132	(ABC) transporter
C4J65_RS34560	COG2375	cellular response to nickel ion
C4J65_RS34565	COG1132	(ABC) transporter
C4J65_RS34585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C4J65_RS34615	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C4J65_RS34635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C4J65_RS34640	COG1846	Transcriptional regulator
C4J65_RS34660	COG4585	Histidine kinase
C4J65_RS34665	COG2197	response regulator
C4J65_RS34730	COG0604	alcohol dehydrogenase
C4J65_RS34730	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS34730	COG3321	synthase
C4J65_RS34755	COG2318	DinB family
C4J65_RS34770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J65_RS34780	COG0583	DNA-binding transcription factor activity
C4J65_RS34800	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS34805	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4J65_RS34810	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C4J65_RS34830	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS34850	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS34860	COG0596	Alpha beta hydrolase
C4J65_RS34875	COG1063	alcohol dehydrogenase
C4J65_RS34895	COG0066	3-isopropylmalate dehydratase activity
C4J65_RS34900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J65_RS34905	COG0473	3-isopropylmalate dehydrogenase activity
C4J65_RS34910	COG1414	Transcriptional regulator
C4J65_RS34925	COG3971	2-oxopent-4-enoate hydratase activity
C4J65_RS34965	COG2205	protein histidine kinase activity
C4J65_RS34970	COG0745	RESPONSE REGULATOR receiver
C4J65_RS34980	COG1131	(ABC) transporter
C4J65_RS34985	COG0069	glutamate synthase activity
C4J65_RS35015	COG0583	DNA-binding transcription factor activity
C4J65_RS35020	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS35075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J65_RS35100	COG0596	Alpha beta hydrolase
C4J65_RS35115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J65_RS35135	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J65_RS35145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4J65_RS35155	COG0251	oxidation-reduction process
C4J65_RS35160	COG1012	belongs to the aldehyde dehydrogenase family
C4J65_RS35170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J65_RS35195	COG0577	efflux transmembrane transporter activity
C4J65_RS35215	COG1846	Transcriptional regulator
C4J65_RS35230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J65_RS35250	COG1309	transcriptional regulator
C4J65_RS35255	COG0778	Nitroreductase
C4J65_RS35260	COG2197	response regulator
C4J65_RS35265	COG4585	Histidine kinase
C4J65_RS35270	COG2409	Drug exporters of the RND superfamily
C4J65_RS35315	COG2378	regulation of single-species biofilm formation
C4J65_RS35325	COG0300	oxidoreductase activity
C4J65_RS35490	COG0531	amino acid
C4J65_RS35510	COG2409	Drug exporters of the RND superfamily
C4J65_RS35545	COG0318	PFAM AMP-dependent synthetase and ligase
C4J65_RS35560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J65_RS35560	COG3320	Male sterility
C4J65_RS35565	COG0604	alcohol dehydrogenase
C4J65_RS35565	COG3321	synthase
C4J65_RS35580	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J65_RS35605	COG3629	intracellular signal transduction
C4J65_RS35605	COG3903	Transcriptional regulator
C4J65_RS35615	COG1309	transcriptional regulator
C4J65_RS35645	COG1233	COG1233 Phytoene dehydrogenase and related
C4J65_RS35650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4J65_RS35655	COG2226	methyltransferase
C4J65_RS35660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4J65_RS35670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J65_RS35680	COG1960	acyl-CoA dehydrogenase activity
C4J65_RS35710	COG0477	Major facilitator Superfamily
C4J65_RS35725	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4J65_RS35730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4J65_RS35730	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4J65_RS35810	COG1028	Short-chain dehydrogenase reductase Sdr
C4J65_RS35935	COG0420	3'-5' exonuclease activity
C4J65_RS35940	COG0419	ATPase involved in DNA repair