locus-tag	class	description
D1369_RS00010	COG0583	DNA-binding transcription factor activity
D1369_RS00020	COG2423	ornithine cyclodeaminase activity
D1369_RS00070	COG2207	Transcriptional regulator
D1369_RS00075	COG0604	alcohol dehydrogenase
D1369_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS00075	COG3321	synthase
D1369_RS00100	COG1660	Displays ATPase and GTPase activities
D1369_RS00125	COG1595	DNA-templated transcription, initiation
D1369_RS00150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1369_RS00155	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1369_RS00160	COG2080	2 iron, 2 sulfur cluster binding
D1369_RS00220	COG0509	glycine decarboxylation via glycine cleavage system
D1369_RS00240	COG1309	transcriptional regulator
D1369_RS00245	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS00310	COG1757	Na H antiporter
D1369_RS00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS00340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1369_RS00350	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS00360	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS00360	COG1024	Enoyl-CoA hydratase
D1369_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS00385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1369_RS00395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1369_RS00405	COG2814	Major facilitator Superfamily
D1369_RS00425	COG1175	transmembrane transport
D1369_RS00430	COG0395	ABC-type sugar transport system, permease component
D1369_RS00445	COG3618	amidohydrolase
D1369_RS00460	COG0583	DNA-binding transcription factor activity
D1369_RS00505	COG0500	methyltransferase
D1369_RS00540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1369_RS00555	COG2130	NADP-dependent
D1369_RS00585	COG2135	peptidase activity
D1369_RS00595	COG3940	Belongs to the glycosyl hydrolase 43 family
D1369_RS00630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS00650	COG1609	Transcriptional regulator
D1369_RS00680	COG2815	serine threonine protein kinase
D1369_RS00680	COG0515	serine threonine protein kinase
D1369_RS00690	COG0515	serine threonine protein kinase
D1369_RS00690	COG2815	serine threonine protein kinase
D1369_RS00695	COG0726	polysaccharide deacetylase
D1369_RS00700	COG0739	heme binding
D1369_RS00780	COG4989	oxidoreductase activity
D1369_RS00800	COG0714	Associated with various cellular activities
D1369_RS00805	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D1369_RS00825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1369_RS00840	COG3634	alkyl hydroperoxide reductase activity
D1369_RS00855	COG0542	response to heat
D1369_RS00870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1369_RS00875	COG0443	Heat shock 70 kDa protein
D1369_RS00885	COG3835	regulator
D1369_RS00900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1369_RS00905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1369_RS00930	COG1902	pentaerythritol trinitrate reductase activity
D1369_RS00935	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS00945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS00955	COG1116	anion transmembrane transporter activity
D1369_RS00960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1369_RS00985	COG0747	negative chemotaxis
D1369_RS00995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS01000	COG4172	Belongs to the ABC transporter superfamily
D1369_RS01025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1369_RS01030	COG0254	rRNA binding
D1369_RS01035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1369_RS01045	COG1278	Cold shock
D1369_RS01050	COG0513	Belongs to the DEAD box helicase family
D1369_RS01095	COG5297	Belongs to the glycosyl hydrolase family 6
D1369_RS01100	COG4733	cellulase activity
D1369_RS01100	COG5297	Belongs to the glycosyl hydrolase family 6
D1369_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS01160	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1369_RS01175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS01185	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1369_RS01215	COG1335	isochorismatase
D1369_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS01305	COG0183	Belongs to the thiolase family
D1369_RS01310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1369_RS01315	COG0183	Belongs to the thiolase family
D1369_RS01325	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01335	COG2268	Band 7 protein
D1369_RS01350	COG2188	Transcriptional regulator
D1369_RS01365	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS01385	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS01400	COG1024	Enoyl-CoA hydratase
D1369_RS01410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS01415	COG0300	oxidoreductase activity
D1369_RS01425	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01430	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01450	COG1024	Enoyl-CoA hydratase
D1369_RS01460	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01485	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS01490	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS01495	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01505	COG1024	Enoyl-CoA hydratase
D1369_RS01510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS01515	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS01525	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01530	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01535	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS01560	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1369_RS01570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1369_RS01585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS01595	COG1960	acyl-CoA dehydrogenase activity
D1369_RS01600	COG1846	Transcriptional regulator
D1369_RS01605	COG0702	epimerase
D1369_RS01615	COG2267	carboxylic ester hydrolase activity
D1369_RS01650	COG2226	methyltransferase
D1369_RS01660	COG2261	transglycosylase associated protein
D1369_RS01685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1369_RS01690	COG0483	inositol monophosphate 1-phosphatase activity
D1369_RS01695	COG0583	DNA-binding transcription factor activity
D1369_RS01700	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D1369_RS01730	COG0667	Aldo Keto reductase
D1369_RS01745	COG1295	ribonuclease BN
D1369_RS01765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1369_RS01770	COG2186	Transcriptional regulator
D1369_RS01830	COG0500	methyltransferase
D1369_RS01835	COG2124	cytochrome p450
D1369_RS01850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1369_RS01865	COG2318	DinB family
D1369_RS01900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS01940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1369_RS01950	COG1940	carbohydrate kinase activity
D1369_RS01955	COG0531	amino acid
D1369_RS01985	COG1609	Transcriptional regulator
D1369_RS02005	COG2267	carboxylic ester hydrolase activity
D1369_RS02020	COG3655	Transcriptional regulator
D1369_RS02065	COG0583	DNA-binding transcription factor activity
D1369_RS02080	COG2226	methyltransferase
D1369_RS02095	COG1063	alcohol dehydrogenase
D1369_RS02145	COG0723	plastoquinol--plastocyanin reductase activity
D1369_RS02145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1369_RS02155	COG0667	Aldo Keto reductase
D1369_RS02165	COG3608	succinylglutamate desuccinylase aspartoacylase
D1369_RS02170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1369_RS02175	COG1177	transmembrane transport
D1369_RS02185	COG3842	ATPase activity
D1369_RS02195	COG3608	succinylglutamate desuccinylase aspartoacylase
D1369_RS02200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1369_RS02205	COG1414	Transcriptional regulator
D1369_RS02210	COG1414	Transcriptional regulator
D1369_RS02215	COG3940	Belongs to the glycosyl hydrolase 43 family
D1369_RS02220	COG3940	Belongs to the glycosyl hydrolase 43 family
D1369_RS02230	COG0247	lactate metabolic process
D1369_RS02230	COG0277	FAD linked oxidase domain protein
D1369_RS02235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1369_RS02250	COG3507	Belongs to the glycosyl hydrolase 43 family
D1369_RS02255	COG3345	alpha-galactosidase
D1369_RS02275	COG4977	sequence-specific DNA binding
D1369_RS02280	COG1765	OsmC-like protein
D1369_RS02325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1369_RS02355	COG1473	amidohydrolase
D1369_RS02390	COG0640	Transcriptional regulator
D1369_RS02420	COG3290	protein histidine kinase activity
D1369_RS02455	COG2755	lipolytic protein G-D-S-L family
D1369_RS02485	COG2080	2 iron, 2 sulfur cluster binding
D1369_RS02490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1369_RS02495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1369_RS02545	COG1132	(ABC) transporter
D1369_RS02580	COG0667	Aldo Keto reductase
D1369_RS02585	COG0673	inositol 2-dehydrogenase activity
D1369_RS02605	COG2409	Drug exporters of the RND superfamily
D1369_RS02640	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1369_RS02665	COG1072	(Pantothenic acid kinase))
D1369_RS02680	COG0395	ABC-type sugar transport system, permease component
D1369_RS02695	COG1940	carbohydrate kinase activity
D1369_RS02765	COG0673	inositol 2-dehydrogenase activity
D1369_RS02795	COG1940	carbohydrate kinase activity
D1369_RS02795	COG1846	Transcriptional regulator
D1369_RS02800	COG1175	transmembrane transport
D1369_RS02805	COG0395	ABC-type sugar transport system, permease component
D1369_RS02810	COG1653	transport
D1369_RS02850	COG1937	Protein conserved in bacteria
D1369_RS02855	COG1132	(ABC) transporter
D1369_RS02875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1369_RS02880	COG3345	alpha-galactosidase
D1369_RS02915	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1369_RS02940	COG0517	IMP dehydrogenase activity
D1369_RS02950	COG0515	serine threonine protein kinase
D1369_RS02960	COG1132	(ABC) transporter
D1369_RS02970	COG2197	response regulator
D1369_RS03020	COG0248	Ppx GppA phosphatase
D1369_RS03030	COG2890	protein-(glutamine-N5) methyltransferase activity
D1369_RS03090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1369_RS03100	COG3250	beta-galactosidase activity
D1369_RS03115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D1369_RS03135	COG0667	Aldo Keto reductase
D1369_RS03165	COG2124	cytochrome p450
D1369_RS03180	COG0435	Glutathione S-transferase
D1369_RS03230	COG4977	sequence-specific DNA binding
D1369_RS03245	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS03250	COG1846	Transcriptional regulator
D1369_RS03260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1369_RS03280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS03285	COG1006	Multisubunit Na H antiporter MnhC subunit
D1369_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS03330	COG1796	DNA polymerase
D1369_RS03330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D1369_RS03365	COG1940	carbohydrate kinase activity
D1369_RS03405	COG2706	6-phosphogluconolactonase activity
D1369_RS03415	COG1309	transcriptional regulator
D1369_RS03425	COG1357	PFAM Pentapeptide repeats (8 copies)
D1369_RS03445	COG1609	Transcriptional regulator
D1369_RS03460	COG1879	ABC-type sugar transport system periplasmic component
D1369_RS03465	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1369_RS03470	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1369_RS03475	COG1129	ABC transporter
D1369_RS03485	COG3347	Dehydrogenase
D1369_RS03485	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS03490	COG1070	Carbohydrate kinase
D1369_RS03495	COG0247	lactate metabolic process
D1369_RS03500	COG1139	Iron-sulfur cluster binding protein
D1369_RS03505	COG1556	Lactate utilization protein
D1369_RS03510	COG3250	beta-galactosidase activity
D1369_RS03525	COG1136	(ABC) transporter
D1369_RS03525	COG0577	efflux transmembrane transporter activity
D1369_RS03555	COG3321	synthase
D1369_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS03555	COG0604	alcohol dehydrogenase
D1369_RS03590	COG1609	Transcriptional regulator
D1369_RS03595	COG1609	Transcriptional regulator
D1369_RS03600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1369_RS03610	COG1295	ribonuclease BN
D1369_RS03645	COG0202	RNA polymerase activity
D1369_RS03655	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D1369_RS03660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D1369_RS03665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D1369_RS03680	COG4249	Peptidase C14 caspase catalytic subunit p20
D1369_RS03680	COG2319	Wd-40 repeat
D1369_RS03700	COG2770	Histidine kinase
D1369_RS03700	COG2208	phosphoserine phosphatase activity
D1369_RS03735	COG0242	peptide deformylase activity
D1369_RS03745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1369_RS03760	COG1609	Transcriptional regulator
D1369_RS03785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS03805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS03820	COG2197	response regulator
D1369_RS03835	COG2353	YceI-like domain
D1369_RS03845	COG3485	protocatechuate 3,4-dioxygenase
D1369_RS03855	COG3284	Transcriptional regulator
D1369_RS03865	COG1595	DNA-templated transcription, initiation
D1369_RS03915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS03935	COG1609	Transcriptional regulator
D1369_RS03945	COG0281	malic enzyme
D1369_RS03975	COG2755	lipolytic protein G-D-S-L family
D1369_RS04020	COG2208	phosphoserine phosphatase activity
D1369_RS04035	COG1131	(ABC) transporter
D1369_RS04055	COG2268	Band 7 protein
D1369_RS04075	COG3572	ergothioneine biosynthetic process
D1369_RS04080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1369_RS04085	COG0121	glutamine amidotransferase
D1369_RS04090	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D1369_RS04095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D1369_RS04100	COG3360	Dodecin
D1369_RS04130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS04150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1369_RS04155	COG1053	succinate dehydrogenase
D1369_RS04165	COG0583	DNA-binding transcription factor activity
D1369_RS04215	COG0726	polysaccharide deacetylase
D1369_RS04255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1369_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS04295	COG4948	Mandelate Racemase Muconate Lactonizing
D1369_RS04305	COG1129	ABC transporter
D1369_RS04315	COG2186	Transcriptional regulator
D1369_RS04335	COG0395	ABC-type sugar transport system, permease component
D1369_RS04340	COG1175	transmembrane transport
D1369_RS04350	COG1609	Transcriptional regulator
D1369_RS04360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1369_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS04410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1369_RS04415	COG0297	glycogen (starch) synthase activity
D1369_RS04430	COG1652	LysM domain
D1369_RS04435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1369_RS04450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1369_RS04470	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D1369_RS04475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1369_RS04480	COG0330	HflC and HflK could
D1369_RS04525	COG1132	(ABC) transporter
D1369_RS04545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1369_RS04560	COG0668	transmembrane transport
D1369_RS04570	COG2838	Isocitrate dehydrogenase
D1369_RS04590	COG1404	Belongs to the peptidase S8 family
D1369_RS04600	COG2197	response regulator
D1369_RS04615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS04620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS04625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS04645	COG1126	abc transporter atp-binding protein
D1369_RS04655	COG0435	Glutathione S-transferase
D1369_RS04660	COG0129	dihydroxy-acid dehydratase activity
D1369_RS04665	COG1414	Transcriptional regulator
D1369_RS04670	COG1063	alcohol dehydrogenase
D1369_RS04685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D1369_RS04715	COG0463	Glycosyl transferase, family 2
D1369_RS04755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1369_RS04760	COG1088	dTDP-glucose 4,6-dehydratase activity
D1369_RS04770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1369_RS04790	COG1132	(ABC) transporter
D1369_RS04840	COG0477	Major facilitator Superfamily
D1369_RS04850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1369_RS04870	COG2828	Protein conserved in bacteria
D1369_RS04875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1369_RS04880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1369_RS04900	COG1609	Transcriptional regulator
D1369_RS04905	COG0673	inositol 2-dehydrogenase activity
D1369_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS04925	COG0673	inositol 2-dehydrogenase activity
D1369_RS04945	COG0673	inositol 2-dehydrogenase activity
D1369_RS04970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS04975	COG3962	Belongs to the TPP enzyme family
D1369_RS04980	COG2188	Transcriptional regulator
D1369_RS04990	COG0494	nUDIX hydrolase
D1369_RS05000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1369_RS05005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1369_RS05010	COG2376	Dihydroxyacetone kinase
D1369_RS05040	COG1011	Hydrolase
D1369_RS05055	COG2267	carboxylic ester hydrolase activity
D1369_RS05090	COG1917	Cupin 2, conserved barrel domain protein
D1369_RS05095	COG0402	S-adenosylhomocysteine deaminase activity
D1369_RS05100	COG0022	dehydrogenase e1 component
D1369_RS05105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1369_RS05110	COG0006	proline dipeptidase activity
D1369_RS05115	COG1396	sequence-specific DNA binding
D1369_RS05120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1369_RS05130	COG0174	glutamine synthetase
D1369_RS05175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1369_RS05205	COG3409	Peptidoglycan-binding domain 1 protein
D1369_RS05260	COG0583	DNA-binding transcription factor activity
D1369_RS05265	COG0156	8-amino-7-oxononanoate synthase activity
D1369_RS05270	COG1063	alcohol dehydrogenase
D1369_RS05340	COG2755	lipolytic protein G-D-S-L family
D1369_RS05355	COG2365	Tyrosine phosphatase family
D1369_RS05375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1369_RS05380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1369_RS05395	COG1657	PFAM Prenyltransferase squalene oxidase
D1369_RS05405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1369_RS05415	COG1562	ergosterol biosynthetic process
D1369_RS05420	COG1134	teichoic acid transport
D1369_RS05465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1369_RS05480	COG1024	Enoyl-CoA hydratase
D1369_RS05495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1369_RS05505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1369_RS05510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS05515	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1369_RS05540	COG0477	Major facilitator Superfamily
D1369_RS05555	COG0753	catalase activity
D1369_RS05590	COG2183	response to ionizing radiation
D1369_RS05595	COG0488	(ABC) transporter
D1369_RS05605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1369_RS05615	COG2936	dipeptidyl-peptidase activity
D1369_RS05630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS05635	COG1113	amino acid transport
D1369_RS05645	COG1024	Enoyl-CoA hydratase
D1369_RS05645	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS05650	COG0183	Belongs to the thiolase family
D1369_RS05655	COG1960	acyl-CoA dehydrogenase activity
D1369_RS05660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS05670	COG3268	Saccharopine dehydrogenase
D1369_RS05680	COG1515	deoxyribonuclease V activity
D1369_RS05715	COG0488	(ABC) transporter
D1369_RS05725	COG1834	amidinotransferase
D1369_RS05775	COG1793	dna ligase
D1369_RS05790	COG1846	Transcriptional regulator
D1369_RS05805	COG0183	Belongs to the thiolase family
D1369_RS05810	COG3485	protocatechuate 3,4-dioxygenase
D1369_RS05815	COG3485	protocatechuate 3,4-dioxygenase
D1369_RS05820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1369_RS05825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1369_RS05835	COG1672	PFAM Archaeal ATPase
D1369_RS05835	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1369_RS05865	COG3511	phospholipase C
D1369_RS05870	COG0477	Major facilitator Superfamily
D1369_RS05890	COG1940	carbohydrate kinase activity
D1369_RS05895	COG0395	ABC-type sugar transport system, permease component
D1369_RS05900	COG1175	transmembrane transport
D1369_RS05925	COG1129	ABC transporter
D1369_RS05935	COG4948	Mandelate Racemase Muconate Lactonizing
D1369_RS05940	COG3618	amidohydrolase
D1369_RS05950	COG1063	alcohol dehydrogenase
D1369_RS05955	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS05960	COG0800	Aldolase
D1369_RS05975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1369_RS06000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1369_RS06005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1369_RS06020	COG0366	Alpha amylase catalytic
D1369_RS06025	COG0395	ABC-type sugar transport system, permease component
D1369_RS06030	COG1175	transmembrane transport
D1369_RS06080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1369_RS06090	COG3469	chitinase activity
D1369_RS06105	COG1486	melibiose metabolic process
D1369_RS06115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS06135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1369_RS06140	COG3250	beta-galactosidase activity
D1369_RS06145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1369_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS06185	COG3850	Histidine kinase
D1369_RS06190	COG2197	response regulator
D1369_RS06200	COG2409	Drug exporters of the RND superfamily
D1369_RS06215	COG0300	oxidoreductase activity
D1369_RS06235	COG3511	phospholipase C
D1369_RS06250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1369_RS06255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1369_RS06270	COG0166	Belongs to the GPI family
D1369_RS06275	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1369_RS06280	COG0588	phosphoglycerate mutase activity
D1369_RS06290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1369_RS06300	COG0477	Major facilitator Superfamily
D1369_RS06305	COG0346	lactoylglutathione lyase activity
D1369_RS06310	COG3467	pyridoxamine 5'-phosphate
D1369_RS06340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1369_RS06360	COG0438	transferase activity, transferring glycosyl groups
D1369_RS06395	COG4166	transmembrane transport
D1369_RS06415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1369_RS06420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1369_RS06435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS06440	COG0028	Belongs to the TPP enzyme family
D1369_RS06445	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS06450	COG0583	DNA-binding transcription factor activity
D1369_RS06460	COG3383	formate dehydrogenase (NAD+) activity
D1369_RS06475	COG1802	Transcriptional regulator
D1369_RS06480	COG1960	acyl-CoA dehydrogenase activity
D1369_RS06495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS06500	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS06510	COG0045	succinate-CoA ligase (ADP-forming) activity
D1369_RS06515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS06520	COG2223	nitrite transmembrane transporter activity
D1369_RS06535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1369_RS06545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1369_RS06565	COG0084	hydrolase, TatD family'
D1369_RS06580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1369_RS06605	COG0673	inositol 2-dehydrogenase activity
D1369_RS06615	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1369_RS06620	COG1129	ABC transporter
D1369_RS06625	COG1940	carbohydrate kinase activity
D1369_RS06640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1369_RS06655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1369_RS06660	COG0583	DNA-binding transcription factor activity
D1369_RS06665	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS06670	COG1335	isochorismatase
D1369_RS06710	COG3250	beta-galactosidase activity
D1369_RS06715	COG3469	chitinase activity
D1369_RS06730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D1369_RS06735	COG0656	L-ascorbic acid biosynthetic process
D1369_RS06755	COG5297	Belongs to the glycosyl hydrolase family 6
D1369_RS06765	COG5297	Belongs to the glycosyl hydrolase family 6
D1369_RS06765	COG4733	cellulase activity
D1369_RS06780	COG3401	FG-GAP repeat protein
D1369_RS06790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1369_RS06795	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1369_RS06825	COG0443	Heat shock 70 kDa protein
D1369_RS06865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1369_RS06930	COG0488	(ABC) transporter
D1369_RS06935	COG2226	methyltransferase
D1369_RS06995	COG3285	dna ligase
D1369_RS06995	COG1793	dna ligase
D1369_RS07000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1369_RS07010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS07055	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1369_RS07060	COG0823	Involved in the tonB-independent uptake of proteins
D1369_RS07060	COG1506	peptidase
D1369_RS07060	COG4946	Tricorn protease homolog
D1369_RS07065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1369_RS07070	COG2362	D-Aminopeptidase
D1369_RS07075	COG3594	Acyltransferase
D1369_RS07080	COG2226	methyltransferase
D1369_RS07085	COG2172	sigma factor antagonist activity
D1369_RS07085	COG2208	phosphoserine phosphatase activity
D1369_RS07085	COG1366	Belongs to the anti-sigma-factor antagonist family
D1369_RS07105	COG0596	Alpha beta hydrolase
D1369_RS07125	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS07140	COG1215	transferase activity, transferring glycosyl groups
D1369_RS07155	COG0604	alcohol dehydrogenase
D1369_RS07160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS07160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS07175	COG1960	acyl-CoA dehydrogenase activity
D1369_RS07180	COG0688	phosphatidylethanolamine metabolic process
D1369_RS07190	COG1929	Belongs to the glycerate kinase type-1 family
D1369_RS07245	COG4585	Histidine kinase
D1369_RS07250	COG2197	response regulator
D1369_RS07255	COG2197	response regulator
D1369_RS07265	COG0494	nUDIX hydrolase
D1369_RS07270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1369_RS07305	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1369_RS07315	COG0483	inositol monophosphate 1-phosphatase activity
D1369_RS07325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1369_RS07330	COG2197	response regulator
D1369_RS07335	COG3851	Histidine kinase
D1369_RS07350	COG1953	Uracil, thiamine, allantoin
D1369_RS07360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1369_RS07375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1369_RS07400	COG0542	response to heat
D1369_RS07410	COG0405	Gamma-glutamyltransferase
D1369_RS07425	COG1126	abc transporter atp-binding protein
D1369_RS07445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1369_RS07485	COG1120	ATPase activity
D1369_RS07490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1369_RS07520	COG1295	ribonuclease BN
D1369_RS07525	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1369_RS07530	COG0667	Aldo Keto reductase
D1369_RS07540	COG4221	oxidoreductase activity
D1369_RS07550	COG1131	(ABC) transporter
D1369_RS07570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1369_RS07580	COG1940	carbohydrate kinase activity
D1369_RS07585	COG2188	Transcriptional regulator
D1369_RS07590	COG0673	inositol 2-dehydrogenase activity
D1369_RS07600	COG2197	response regulator
D1369_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS07625	COG4266	Belongs to the allantoicase family
D1369_RS07630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1369_RS07635	COG1414	Transcriptional regulator
D1369_RS07650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1369_RS07720	COG0436	Aminotransferase
D1369_RS07745	COG0406	alpha-ribazole phosphatase activity
D1369_RS07760	COG1733	regulation of RNA biosynthetic process
D1369_RS07785	COG2233	PERMEase
D1369_RS07800	COG2351	hydroxyisourate hydrolase activity
D1369_RS07820	COG3622	Belongs to the hyi family
D1369_RS07825	COG2084	Dehydrogenase
D1369_RS07835	COG3960	tartronate-semialdehyde synthase activity
D1369_RS07845	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS07850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1369_RS07855	COG2197	response regulator
D1369_RS07875	COG0598	Magnesium transport protein CorA
D1369_RS07880	COG0494	nUDIX hydrolase
D1369_RS07920	COG3209	COG3209 Rhs family protein
D1369_RS07975	COG1725	Transcriptional regulator
D1369_RS07980	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D1369_RS08025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS08080	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1369_RS08095	COG2252	PERMEase
D1369_RS08100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1369_RS08115	COG3835	regulator
D1369_RS08125	COG1802	Transcriptional regulator
D1369_RS08170	COG0028	Belongs to the TPP enzyme family
D1369_RS08190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1369_RS08200	COG1162	GTPase activity
D1369_RS08225	COG3693	PFAM glycoside hydrolase, family 10
D1369_RS08235	COG1595	DNA-templated transcription, initiation
D1369_RS08255	COG2259	Doxx family
D1369_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS08265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1369_RS08285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS08305	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1369_RS08325	COG0346	lactoylglutathione lyase activity
D1369_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS08350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS08355	COG3938	Belongs to the proline racemase family
D1369_RS08365	COG5297	Belongs to the glycosyl hydrolase family 6
D1369_RS08380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1369_RS08385	COG0277	FAD linked oxidase domain protein
D1369_RS08405	COG1175	transmembrane transport
D1369_RS08410	COG0395	ABC-type sugar transport system, permease component
D1369_RS08420	COG1131	(ABC) transporter
D1369_RS08445	COG2319	Wd-40 repeat
D1369_RS08445	COG4249	Peptidase C14 caspase catalytic subunit p20
D1369_RS08470	COG2755	lipolytic protein G-D-S-L family
D1369_RS08495	COG2040	homocysteine
D1369_RS08500	COG2326	polyphosphate kinase activity
D1369_RS08515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS08530	COG1609	Transcriptional regulator
D1369_RS08585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS08600	COG2423	ornithine cyclodeaminase activity
D1369_RS08605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1369_RS08610	COG1960	acyl-CoA dehydrogenase activity
D1369_RS08640	COG0175	sulfate reduction
D1369_RS08645	COG0529	Catalyzes the synthesis of activated sulfate
D1369_RS08670	COG1116	anion transmembrane transporter activity
D1369_RS08685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1369_RS08695	COG0604	alcohol dehydrogenase
D1369_RS08740	COG2814	Major facilitator Superfamily
D1369_RS08755	COG2814	Major facilitator Superfamily
D1369_RS08775	COG2409	Drug exporters of the RND superfamily
D1369_RS08785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1369_RS08800	COG1175	transmembrane transport
D1369_RS08810	COG0583	DNA-binding transcription factor activity
D1369_RS08895	COG1280	lysine exporter protein (LysE YggA)
D1369_RS08900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1369_RS08905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1369_RS08925	COG3903	Transcriptional regulator
D1369_RS08925	COG3629	intracellular signal transduction
D1369_RS08955	COG1404	Belongs to the peptidase S8 family
D1369_RS09030	COG5002	protein histidine kinase activity
D1369_RS09035	COG2018	Roadblock/LC7 domain
D1369_RS09050	COG1174	glycine betaine transport
D1369_RS09055	COG1174	glycine betaine transport
D1369_RS09065	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1369_RS09070	COG1477	protein flavinylation
D1369_RS09085	COG0745	RESPONSE REGULATOR receiver
D1369_RS09090	COG2205	protein histidine kinase activity
D1369_RS09095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1369_RS09100	COG5002	protein histidine kinase activity
D1369_RS09105	COG0745	RESPONSE REGULATOR receiver
D1369_RS09135	COG0791	NLP P60 protein
D1369_RS09135	COG3883	PFAM NLP P60 protein
D1369_RS09140	COG1595	DNA-templated transcription, initiation
D1369_RS09150	COG3629	intracellular signal transduction
D1369_RS09150	COG3903	Transcriptional regulator
D1369_RS09165	COG4821	SIS domain
D1369_RS09170	COG1737	Transcriptional regulator
D1369_RS09190	COG1175	transmembrane transport
D1369_RS09195	COG0395	ABC-type sugar transport system, permease component
D1369_RS09215	COG1472	Belongs to the glycosyl hydrolase 3 family
D1369_RS09230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1369_RS09235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1369_RS09270	COG0330	HflC and HflK could
D1369_RS09280	COG2326	polyphosphate kinase activity
D1369_RS09285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1369_RS09285	COG0723	plastoquinol--plastocyanin reductase activity
D1369_RS09315	COG3220	belongs to the UPF0276 family
D1369_RS09335	COG3253	May function as heme-dependent peroxidase
D1369_RS09350	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1369_RS09365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1369_RS09380	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1369_RS09385	COG0395	ABC-type sugar transport system, permease component
D1369_RS09390	COG1175	transmembrane transport
D1369_RS09400	COG3250	beta-galactosidase activity
D1369_RS09405	COG1609	Transcriptional regulator
D1369_RS09410	COG0183	Belongs to the thiolase family
D1369_RS09415	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS09415	COG1024	Enoyl-CoA hydratase
D1369_RS09430	COG0531	amino acid
D1369_RS09435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1369_RS09440	COG4214	carbohydrate transport
D1369_RS09450	COG4213	ABC transporter substrate-binding protein
D1369_RS09455	COG1940	carbohydrate kinase activity
D1369_RS09460	COG0395	ABC-type sugar transport system, permease component
D1369_RS09465	COG1175	transmembrane transport
D1369_RS09470	COG1653	transport
D1369_RS09500	COG0395	ABC-type sugar transport system, permease component
D1369_RS09505	COG4209	transmembrane transport
D1369_RS09510	COG3458	cephalosporin-C deacetylase activity
D1369_RS09515	COG3537	Alpha-1,2-mannosidase
D1369_RS09540	COG2205	protein histidine kinase activity
D1369_RS09545	COG0745	RESPONSE REGULATOR receiver
D1369_RS09550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1369_RS09565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1369_RS09570	COG1473	amidohydrolase
D1369_RS09575	COG2267	carboxylic ester hydrolase activity
D1369_RS09580	COG2267	carboxylic ester hydrolase activity
D1369_RS09605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1369_RS09620	COG0475	glutathione-regulated potassium exporter activity
D1369_RS09640	COG0583	DNA-binding transcription factor activity
D1369_RS09655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1369_RS09665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS09700	COG2192	nodulation
D1369_RS09705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1369_RS09710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1369_RS09715	COG0512	Glutamine amidotransferase of anthranilate synthase
D1369_RS09725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1369_RS09810	COG1024	Enoyl-CoA hydratase
D1369_RS09820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1369_RS09825	COG2235	arginine
D1369_RS09840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1369_RS09870	COG1799	cell septum assembly
D1369_RS09910	COG0243	molybdopterin cofactor binding
D1369_RS09920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1369_RS09925	COG0436	Aminotransferase
D1369_RS09945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1369_RS09950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1369_RS09955	COG2080	2 iron, 2 sulfur cluster binding
D1369_RS10005	COG0702	epimerase
D1369_RS10030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS10045	COG1733	regulation of RNA biosynthetic process
D1369_RS10055	COG0475	glutathione-regulated potassium exporter activity
D1369_RS10070	COG0745	RESPONSE REGULATOR receiver
D1369_RS10095	COG0745	RESPONSE REGULATOR receiver
D1369_RS10100	COG4770	biotin carboxylase activity
D1369_RS10115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1369_RS10135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS10150	COG2814	Major facilitator Superfamily
D1369_RS10160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1369_RS10185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D1369_RS10185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS10195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1369_RS10200	COG0531	amino acid
D1369_RS10205	COG0569	domain protein
D1369_RS10240	COG1136	(ABC) transporter
D1369_RS10240	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1369_RS10255	COG0756	dUTP diphosphatase activity
D1369_RS10280	COG2205	protein histidine kinase activity
D1369_RS10285	COG0745	RESPONSE REGULATOR receiver
D1369_RS10295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1369_RS10330	COG1435	thymidine kinase activity
D1369_RS10355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1369_RS10360	COG1802	Transcriptional regulator
D1369_RS10375	COG0612	Peptidase, M16
D1369_RS10380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1369_RS10385	COG0523	cobalamin synthesis protein
D1369_RS10400	COG0372	Belongs to the citrate synthase family
D1369_RS10415	COG3290	protein histidine kinase activity
D1369_RS10420	COG4565	transcriptional regulatory protein
D1369_RS10430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1369_RS10440	COG4565	transcriptional regulatory protein
D1369_RS10445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1369_RS10455	COG2197	response regulator
D1369_RS10470	COG0187	DNA topoisomerase II activity
D1369_RS10485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1369_RS10490	COG1802	Transcriptional regulator
D1369_RS10515	COG0514	ATP-dependent DNA helicase (RecQ)
D1369_RS10530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1369_RS10550	COG0588	phosphoglycerate mutase activity
D1369_RS10570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1369_RS10575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1369_RS10580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1369_RS10610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1369_RS10620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1369_RS10625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1369_RS10635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1369_RS10660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1369_RS10670	COG0137	argininosuccinate synthase activity
D1369_RS10675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS10690	COG2197	response regulator
D1369_RS10695	COG4585	Histidine kinase
D1369_RS10710	COG2358	TRAP transporter, solute receptor (TAXI family
D1369_RS10715	COG2205	protein histidine kinase activity
D1369_RS10720	COG0745	RESPONSE REGULATOR receiver
D1369_RS10725	COG1126	abc transporter atp-binding protein
D1369_RS10730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1369_RS10735	COG0765	amino acid transport
D1369_RS10740	COG0765	amino acid transport
D1369_RS10760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1369_RS10790	COG1201	RNA secondary structure unwinding
D1369_RS10795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1369_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS10810	COG1396	sequence-specific DNA binding
D1369_RS10815	COG1058	Belongs to the CinA family
D1369_RS10815	COG1546	Belongs to the CinA family
D1369_RS10825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1369_RS10835	COG1674	ftsk spoiiie
D1369_RS10845	COG0784	Response regulator, receiver
D1369_RS10845	COG2205	protein histidine kinase activity
D1369_RS10855	COG2208	phosphoserine phosphatase activity
D1369_RS10855	COG2770	Histidine kinase
D1369_RS10890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D1369_RS10895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS10900	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D1369_RS10920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1369_RS10925	COG0612	Peptidase, M16
D1369_RS10930	COG1185	polyribonucleotide nucleotidyltransferase activity
D1369_RS10935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1369_RS10945	COG1674	ftsk spoiiie
D1369_RS11065	COG1404	Belongs to the peptidase S8 family
D1369_RS11080	COG1404	Belongs to the peptidase S8 family
D1369_RS11115	COG0455	bacterial-type flagellum organization
D1369_RS11130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1369_RS11135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1369_RS11145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1369_RS11160	COG0779	Required for maturation of 30S ribosomal subunits
D1369_RS11185	COG0442	prolyl-tRNA aminoacylation
D1369_RS11200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1369_RS11205	COG0750	zinc metalloprotease
D1369_RS11210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D1369_RS11230	COG1605	Chorismate mutase
D1369_RS11255	COG0395	ABC-type sugar transport system, permease component
D1369_RS11260	COG4209	transmembrane transport
D1369_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS11285	COG2508	Transcriptional regulator
D1369_RS11305	COG1401	restriction endodeoxyribonuclease activity
D1369_RS11325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1369_RS11330	COG1177	transmembrane transport
D1369_RS11340	COG3842	ATPase activity
D1369_RS11370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1369_RS11375	COG0584	glycerophosphoryl diester phosphodiesterase
D1369_RS11385	COG1733	regulation of RNA biosynthetic process
D1369_RS11415	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS11425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1369_RS11460	COG3842	ATPase activity
D1369_RS11465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D1369_RS11475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1369_RS11495	COG0575	Belongs to the CDS family
D1369_RS11500	COG0233	cytoplasmic translational termination
D1369_RS11505	COG0528	UMP kinase activity
D1369_RS11510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1369_RS11515	COG0052	Belongs to the universal ribosomal protein uS2 family
D1369_RS11520	COG4942	peptidase
D1369_RS11530	COG1191	sigma factor activity
D1369_RS11545	COG0792	nuclease activity
D1369_RS11565	COG0681	Belongs to the peptidase S26 family
D1369_RS11570	COG0681	Belongs to the peptidase S26 family
D1369_RS11580	COG0335	large ribosomal subunit rRNA binding
D1369_RS11585	COG0336	Belongs to the RNA methyltransferase TrmD family
D1369_RS11590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1369_RS11595	COG1837	Belongs to the UPF0109 family
D1369_RS11600	COG0228	four-way junction DNA binding
D1369_RS11610	COG0442	prolyl-tRNA aminoacylation
D1369_RS11625	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1369_RS11665	COG0477	Major facilitator Superfamily
D1369_RS11670	COG1196	nuclear chromosome segregation
D1369_RS11680	COG1254	Belongs to the acylphosphatase family
D1369_RS11685	COG2340	Cysteine-rich secretory protein family
D1369_RS11690	COG1733	regulation of RNA biosynthetic process
D1369_RS11695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1369_RS11700	COG0571	ribonuclease III activity
D1369_RS11705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1369_RS11720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1369_RS11725	COG0742	ribosomal rna small subunit methyltransferase
D1369_RS11735	COG0326	Molecular chaperone. Has ATPase activity
D1369_RS11745	COG1461	Dihydroxyacetone kinase
D1369_RS11750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1369_RS11755	COG0351	phosphomethylpyrimidine kinase
D1369_RS11775	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1369_RS11780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1369_RS11790	COG1920	GTP binding
D1369_RS11800	COG0776	regulation of translation
D1369_RS11810	COG0066	3-isopropylmalate dehydratase activity
D1369_RS11815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1369_RS11820	COG1414	Transcriptional regulator
D1369_RS11855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1369_RS11860	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1369_RS11870	COG5002	protein histidine kinase activity
D1369_RS11875	COG2018	Roadblock/LC7 domain
D1369_RS11895	COG2018	Roadblock/LC7 domain
D1369_RS11915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1369_RS11920	COG5492	domain, Protein
D1369_RS11960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1369_RS11990	COG2957	Belongs to the agmatine deiminase family
D1369_RS11995	COG0804	urea catabolic process
D1369_RS12005	COG0832	Belongs to the urease beta subunit family
D1369_RS12005	COG0831	urea catabolic process
D1369_RS12010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1369_RS12015	COG0473	3-isopropylmalate dehydrogenase activity
D1369_RS12030	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS12035	COG0506	proline dehydrogenase activity
D1369_RS12055	COG0477	Major facilitator Superfamily
D1369_RS12060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1369_RS12065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1369_RS12070	COG0440	acetolactate synthase activity
D1369_RS12080	COG5001	Diguanylate cyclase
D1369_RS12080	COG3300	MHYT domain
D1369_RS12090	COG0667	Aldo Keto reductase
D1369_RS12095	COG2133	pyrroloquinoline quinone binding
D1369_RS12105	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1369_RS12105	COG1672	PFAM Archaeal ATPase
D1369_RS12120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1369_RS12125	COG2409	Drug exporters of the RND superfamily
D1369_RS12140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1369_RS12150	COG0154	amidase activity
D1369_RS12155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1369_RS12165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1369_RS12175	COG4221	oxidoreductase activity
D1369_RS12180	COG1611	Belongs to the LOG family
D1369_RS12190	COG0596	Alpha beta hydrolase
D1369_RS12195	COG0482	sulfurtransferase activity
D1369_RS12200	COG3023	N-Acetylmuramoyl-L-alanine amidase
D1369_RS12205	COG2132	Multicopper oxidase
D1369_RS12245	COG2860	membrane
D1369_RS12255	COG4608	Belongs to the ABC transporter superfamily
D1369_RS12260	COG0444	Belongs to the ABC transporter superfamily
D1369_RS12265	COG0601	transmembrane transport
D1369_RS12270	COG0747	negative chemotaxis
D1369_RS12275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS12300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1369_RS12305	COG0509	glycine decarboxylation via glycine cleavage system
D1369_RS12310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1369_RS12315	COG1760	l-serine dehydratase
D1369_RS12360	COG1376	ErfK ybiS ycfS ynhG family protein
D1369_RS12365	COG1376	ErfK ybiS ycfS ynhG family protein
D1369_RS12375	COG3119	arylsulfatase activity
D1369_RS12380	COG2197	response regulator
D1369_RS12385	COG4585	Histidine kinase
D1369_RS12395	COG1131	(ABC) transporter
D1369_RS12400	COG1132	(ABC) transporter
D1369_RS12405	COG1132	(ABC) transporter
D1369_RS12410	COG1132	(ABC) transporter
D1369_RS12415	COG1132	(ABC) transporter
D1369_RS12435	COG0058	SHG alpha-glucan phosphorylase activity
D1369_RS12445	COG0366	Alpha amylase catalytic
D1369_RS12455	COG3281	Trehalose synthase
D1369_RS12460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1369_RS12500	COG0477	Major facilitator Superfamily
D1369_RS12510	COG1301	dicarboxylic acid transport
D1369_RS12520	COG4565	transcriptional regulatory protein
D1369_RS12530	COG4209	transmembrane transport
D1369_RS12535	COG0395	ABC-type sugar transport system, permease component
D1369_RS12550	COG0205	6-phosphofructokinase activity
D1369_RS12555	COG0857	belongs to the CobB CobQ family
D1369_RS12555	COG0280	phosphate acetyltransferase
D1369_RS12560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1369_RS12605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS12605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS12670	COG0745	RESPONSE REGULATOR receiver
D1369_RS12685	COG0183	Belongs to the thiolase family
D1369_RS12690	COG0346	lactoylglutathione lyase activity
D1369_RS12705	COG1131	(ABC) transporter
D1369_RS12740	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1369_RS12755	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS12785	COG4585	Histidine kinase
D1369_RS12790	COG2197	response regulator
D1369_RS12805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1369_RS12810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1369_RS12815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1369_RS12820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1369_RS12825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1369_RS12830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1369_RS12835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1369_RS12850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1369_RS12855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1369_RS12860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1369_RS12870	COG2890	protein-(glutamine-N5) methyltransferase activity
D1369_RS12875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1369_RS12880	COG0254	rRNA binding
D1369_RS12900	COG0083	homoserine kinase activity
D1369_RS12905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1369_RS12910	COG0460	homoserine dehydrogenase
D1369_RS12915	COG0019	diaminopimelate decarboxylase activity
D1369_RS12920	COG0018	arginyl-trna synthetase
D1369_RS12920	COG0018	arginyl-trna synthetase
D1369_RS12925	COG0745	RESPONSE REGULATOR receiver
D1369_RS12965	COG3594	Acyltransferase
D1369_RS12970	COG1595	DNA-templated transcription, initiation
D1369_RS12985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D1369_RS12990	COG1793	dna ligase
D1369_RS12990	COG3285	dna ligase
D1369_RS13010	COG2205	protein histidine kinase activity
D1369_RS13105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1369_RS13130	COG0745	RESPONSE REGULATOR receiver
D1369_RS13135	COG2205	protein histidine kinase activity
D1369_RS13140	COG0567	Dehydrogenase, E1 component
D1369_RS13140	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1369_RS13175	COG0604	alcohol dehydrogenase
D1369_RS13180	COG0281	malic enzyme
D1369_RS13195	COG0765	amino acid transport
D1369_RS13200	COG1126	abc transporter atp-binding protein
D1369_RS13205	COG4106	trans-aconitate 2-methyltransferase activity
D1369_RS13230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1369_RS13235	COG2326	polyphosphate kinase activity
D1369_RS13275	COG4941	Belongs to the sigma-70 factor family
D1369_RS13290	COG0456	acetyltransferase
D1369_RS13295	COG0142	geranyltranstransferase activity
D1369_RS13300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1369_RS13310	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D1369_RS13340	COG1597	lipid kinase activity
D1369_RS13355	COG1309	transcriptional regulator
D1369_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS13365	COG0363	glucosamine-6-phosphate deaminase activity
D1369_RS13370	COG1472	Belongs to the glycosyl hydrolase 3 family
D1369_RS13375	COG0395	ABC-type sugar transport system, permease component
D1369_RS13380	COG1175	transmembrane transport
D1369_RS13385	COG2182	Extracellular solute-binding protein
D1369_RS13390	COG2188	Transcriptional regulator
D1369_RS13395	COG1966	Carbon starvation protein
D1369_RS13425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1369_RS13445	COG2124	cytochrome p450
D1369_RS13455	COG0242	peptide deformylase activity
D1369_RS13470	COG2199	diguanylate cyclase activity
D1369_RS13470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1369_RS13475	COG5662	AntiSigma factor
D1369_RS13480	COG1595	DNA-templated transcription, initiation
D1369_RS13490	COG2135	peptidase activity
D1369_RS13500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1369_RS13505	COG1162	GTPase activity
D1369_RS13520	COG0483	inositol monophosphate 1-phosphatase activity
D1369_RS13565	COG1615	UPF0182 protein
D1369_RS13575	COG3480	Lon protease (S16) C-terminal proteolytic domain
D1369_RS13625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1369_RS13660	COG2816	NAD+ diphosphatase activity
D1369_RS13665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1369_RS13670	COG0210	DNA helicase
D1369_RS13735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS13785	COG0513	Belongs to the DEAD box helicase family
D1369_RS13795	COG1432	Conserved Protein
D1369_RS13805	COG2095	MarC family integral membrane protein
D1369_RS13820	COG2814	Major facilitator Superfamily
D1369_RS13830	COG0598	Magnesium transport protein CorA
D1369_RS13870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1369_RS13875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1369_RS13885	COG1595	DNA-templated transcription, initiation
D1369_RS13900	COG1024	Enoyl-CoA hydratase
D1369_RS13905	COG2818	Glycosylase
D1369_RS13915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1369_RS13925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1369_RS13960	COG2197	response regulator
D1369_RS13965	COG4585	Histidine kinase
D1369_RS13975	COG1131	(ABC) transporter
D1369_RS13990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1369_RS14005	COG4608	Belongs to the ABC transporter superfamily
D1369_RS14015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS14020	COG0601	transmembrane transport
D1369_RS14035	COG0601	transmembrane transport
D1369_RS14040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS14045	COG0444	Belongs to the ABC transporter superfamily
D1369_RS14055	COG0346	lactoylglutathione lyase activity
D1369_RS14060	COG4608	Belongs to the ABC transporter superfamily
D1369_RS14065	COG0444	Belongs to the ABC transporter superfamily
D1369_RS14070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS14080	COG0747	negative chemotaxis
D1369_RS14085	COG1217	gtp-binding protein TYPA
D1369_RS14105	COG1053	succinate dehydrogenase
D1369_RS14165	COG0300	oxidoreductase activity
D1369_RS14170	COG0583	DNA-binding transcription factor activity
D1369_RS14175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1369_RS14180	COG0012	GTP binding
D1369_RS14195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1369_RS14200	COG1570	exodeoxyribonuclease VII activity
D1369_RS14205	COG1722	exodeoxyribonuclease VII activity
D1369_RS14210	COG0778	Nitroreductase
D1369_RS14235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D1369_RS14235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D1369_RS14240	COG0114	fumarate hydratase activity
D1369_RS14255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1369_RS14275	COG1136	(ABC) transporter
D1369_RS14305	COG0741	lytic transglycosylase activity
D1369_RS14310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D1369_RS14315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1369_RS14370	COG1404	Belongs to the peptidase S8 family
D1369_RS14425	COG2197	response regulator
D1369_RS14430	COG4585	Histidine kinase
D1369_RS14460	COG2894	cell division
D1369_RS14505	COG2610	gluconate transmembrane transporter activity
D1369_RS14510	COG0251	oxidation-reduction process
D1369_RS14515	COG1414	Transcriptional regulator
D1369_RS14530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D1369_RS14545	COG0436	Aminotransferase
D1369_RS14575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D1369_RS14585	COG0477	Major facilitator Superfamily
D1369_RS14590	COG1309	transcriptional regulator
D1369_RS14600	COG1331	Highly conserved protein containing a thioredoxin domain
D1369_RS14605	COG2255	four-way junction helicase activity
D1369_RS14615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1369_RS14625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1369_RS14640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1369_RS14645	COG2255	four-way junction helicase activity
D1369_RS14670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1369_RS14705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1369_RS14730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1369_RS14735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1369_RS14740	COG1064	alcohol dehydrogenase
D1369_RS14755	COG1404	Belongs to the peptidase S8 family
D1369_RS14760	COG1136	(ABC) transporter
D1369_RS14785	COG2986	histidine ammonia-lyase
D1369_RS14795	COG1024	Enoyl-CoA hydratase
D1369_RS14805	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1369_RS14815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1369_RS14835	COG0424	maF-like protein
D1369_RS14845	COG4770	biotin carboxylase activity
D1369_RS14880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1369_RS14895	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS14900	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS14915	COG1595	DNA-templated transcription, initiation
D1369_RS14920	COG0745	RESPONSE REGULATOR receiver
D1369_RS14925	COG2205	protein histidine kinase activity
D1369_RS14950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1369_RS14960	COG0583	DNA-binding transcription factor activity
D1369_RS14965	COG2814	Major facilitator Superfamily
D1369_RS15000	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1369_RS15005	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1369_RS15010	COG3845	ABC transporter
D1369_RS15015	COG1744	ABC transporter substrate-binding protein PnrA-like
D1369_RS15020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1369_RS15020	COG1473	amidohydrolase
D1369_RS15045	COG2226	methyltransferase
D1369_RS15085	COG2089	acid synthase
D1369_RS15100	COG1216	Glycosyl transferase, family 2
D1369_RS15110	COG0463	Glycosyl transferase, family 2
D1369_RS15120	COG1233	COG1233 Phytoene dehydrogenase and related
D1369_RS15140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D1369_RS15160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS15160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS15180	COG1595	DNA-templated transcription, initiation
D1369_RS15200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1369_RS15255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1369_RS15265	COG2009	succinate dehydrogenase
D1369_RS15275	COG1053	succinate dehydrogenase
D1369_RS15340	COG2409	Drug exporters of the RND superfamily
D1369_RS15345	COG0745	RESPONSE REGULATOR receiver
D1369_RS15350	COG2205	protein histidine kinase activity
D1369_RS15360	COG1408	metallophosphoesterase
D1369_RS15370	COG1686	Belongs to the peptidase S11 family
D1369_RS15375	COG1295	ribonuclease BN
D1369_RS15395	COG0180	Tryptophanyl-tRNA synthetase
D1369_RS15415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1369_RS15430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1369_RS15435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1369_RS15440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1369_RS15455	COG4176	ABC-type proline glycine betaine transport system permease component
D1369_RS15460	COG0517	IMP dehydrogenase activity
D1369_RS15460	COG4175	Glycine betaine
D1369_RS15470	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS15490	COG0454	-acetyltransferase
D1369_RS15500	COG0477	Major facilitator Superfamily
D1369_RS15510	COG0039	L-malate dehydrogenase activity
D1369_RS15530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1369_RS15545	COG0138	bifunctional purine biosynthesis protein purh
D1369_RS15575	COG0045	succinate-CoA ligase (ADP-forming) activity
D1369_RS15590	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D1369_RS15595	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D1369_RS15600	COG0714	Associated with various cellular activities
D1369_RS15615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS15615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS15625	COG0739	heme binding
D1369_RS15650	COG0791	NLP P60 protein
D1369_RS15655	COG2197	response regulator
D1369_RS15700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1369_RS15700	COG0519	Catalyzes the synthesis of GMP from XMP
D1369_RS15725	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS15745	COG0515	serine threonine protein kinase
D1369_RS15750	COG0515	serine threonine protein kinase
D1369_RS15755	COG2815	serine threonine protein kinase
D1369_RS15755	COG0515	serine threonine protein kinase
D1369_RS15770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1369_RS15785	COG0516	GMP reductase activity
D1369_RS15795	COG1595	DNA-templated transcription, initiation
D1369_RS15810	COG0583	DNA-binding transcription factor activity
D1369_RS15820	COG4221	oxidoreductase activity
D1369_RS15830	COG0459	protein refolding
D1369_RS15835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1369_RS15840	COG0726	polysaccharide deacetylase
D1369_RS15845	COG0726	polysaccharide deacetylase
D1369_RS15860	COG4941	Belongs to the sigma-70 factor family
D1369_RS15880	COG1609	Transcriptional regulator
D1369_RS15895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1369_RS15915	COG0802	atpase or kinase
D1369_RS15925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1369_RS15940	COG0736	holo-[acyl-carrier-protein] synthase activity
D1369_RS15980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1369_RS16005	COG1072	(Pantothenic acid kinase))
D1369_RS16015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1369_RS16020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1369_RS16025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1369_RS16050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1369_RS16055	COG2755	lipolytic protein G-D-S-L family
D1369_RS16055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D1369_RS16060	COG0101	tRNA pseudouridine synthase activity
D1369_RS16065	COG0203	ribosomal protein L17
D1369_RS16070	COG0202	RNA polymerase activity
D1369_RS16075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1369_RS16080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1369_RS16085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1369_RS16090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1369_RS16100	COG0563	adenylate kinase activity
D1369_RS16110	COG0200	Binds to the 23S rRNA
D1369_RS16115	COG1841	ribosomal large subunit assembly
D1369_RS16120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1369_RS16125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1369_RS16130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1369_RS16135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1369_RS16145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1369_RS16150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1369_RS16155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1369_RS16160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1369_RS16165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1369_RS16170	COG0255	Belongs to the universal ribosomal protein uL29 family
D1369_RS16175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1369_RS16180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1369_RS16185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1369_RS16190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1369_RS16195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1369_RS16200	COG0089	rRNA binding
D1369_RS16205	COG0088	Forms part of the polypeptide exit tunnel
D1369_RS16210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1369_RS16215	COG0051	transcription antitermination factor activity, RNA binding
D1369_RS16240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1369_RS16245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1369_RS16250	COG0049	tRNA binding
D1369_RS16255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1369_RS16295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1369_RS16300	COG0085	RNA polymerase activity
D1369_RS16310	COG0222	ribosome binding
D1369_RS16315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1369_RS16330	COG0081	regulation of translation
D1369_RS16335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1369_RS16340	COG0250	Participates in transcription elongation, termination and antitermination
D1369_RS16355	COG0436	Aminotransferase
D1369_RS16360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1369_RS16365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1369_RS16370	COG0477	Major facilitator Superfamily
D1369_RS16385	COG2030	dehydratase
D1369_RS16390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1369_RS16405	COG0402	S-adenosylhomocysteine deaminase activity
D1369_RS16435	COG1666	GTP binding
D1369_RS16440	COG2261	transglycosylase associated protein
D1369_RS16460	COG3304	Inner membrane component domain
D1369_RS16465	COG0501	Belongs to the peptidase M48B family
D1369_RS16470	COG1007	ATP synthesis coupled electron transport
D1369_RS16475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS16480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1369_RS16485	COG0713	ATP synthesis coupled electron transport
D1369_RS16490	COG0839	Belongs to the complex I subunit 6 family
D1369_RS16495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS16500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1369_RS16510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS16515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS16525	COG4585	Histidine kinase
D1369_RS16540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1369_RS16540	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1369_RS16545	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1369_RS16550	COG1733	regulation of RNA biosynthetic process
D1369_RS16555	COG0702	epimerase
D1369_RS16595	COG0154	amidase activity
D1369_RS16600	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1369_RS16620	COG0142	geranyltranstransferase activity
D1369_RS16635	COG0561	phosphatase activity
D1369_RS16645	COG0395	ABC-type sugar transport system, permease component
D1369_RS16650	COG1175	transmembrane transport
D1369_RS16665	COG0492	ferredoxin-NADP+ reductase activity
D1369_RS16685	COG2188	Transcriptional regulator
D1369_RS16710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1369_RS16715	COG0514	ATP-dependent DNA helicase (RecQ)
D1369_RS16725	COG1007	ATP synthesis coupled electron transport
D1369_RS16735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1369_RS16740	COG0713	ATP synthesis coupled electron transport
D1369_RS16745	COG0839	Belongs to the complex I subunit 6 family
D1369_RS16750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS16755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1369_RS16760	COG1034	ATP synthesis coupled electron transport
D1369_RS16765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1369_RS16775	COG0649	NAD binding
D1369_RS16780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS16785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1369_RS16820	COG2226	methyltransferase
D1369_RS16840	COG3979	chitinase
D1369_RS16850	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1369_RS16860	COG0515	serine threonine protein kinase
D1369_RS16860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1369_RS16865	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1369_RS16870	COG1278	Cold shock
D1369_RS16875	COG1396	sequence-specific DNA binding
D1369_RS16890	COG2226	methyltransferase
D1369_RS16900	COG1053	succinate dehydrogenase
D1369_RS17020	COG0183	Belongs to the thiolase family
D1369_RS17025	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS17035	COG1309	transcriptional regulator
D1369_RS17055	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1369_RS17065	COG0163	prenyltransferase activity
D1369_RS17075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1369_RS17085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1369_RS17120	COG0604	alcohol dehydrogenase
D1369_RS17130	COG2124	cytochrome p450
D1369_RS17155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1369_RS17170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1369_RS17175	COG1333	cytochrome c biogenesis protein
D1369_RS17180	COG0785	Cytochrome C biogenesis protein
D1369_RS17185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1369_RS17195	COG0406	alpha-ribazole phosphatase activity
D1369_RS17200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1369_RS17230	COG0477	Major facilitator Superfamily
D1369_RS17235	COG3387	PFAM Glycoside hydrolase 15-related
D1369_RS17265	COG1597	lipid kinase activity
D1369_RS17270	COG2723	6-phospho-beta-galactosidase activity
D1369_RS17275	COG0395	ABC-type sugar transport system, permease component
D1369_RS17280	COG1175	transmembrane transport
D1369_RS17285	COG2182	Extracellular solute-binding protein
D1369_RS17290	COG1940	carbohydrate kinase activity
D1369_RS17300	COG1621	beta-fructofuranosidase activity
D1369_RS17325	COG1609	Transcriptional regulator
D1369_RS17340	COG0477	Major facilitator Superfamily
D1369_RS17370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS17380	COG0604	alcohol dehydrogenase
D1369_RS17385	COG1733	regulation of RNA biosynthetic process
D1369_RS17395	COG1742	UPF0060 membrane protein
D1369_RS17410	COG1690	Belongs to the RtcB family
D1369_RS17430	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1369_RS17435	COG0018	arginyl-trna synthetase
D1369_RS17440	COG0515	serine threonine protein kinase
D1369_RS17440	COG2815	serine threonine protein kinase
D1369_RS17485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1369_RS17495	COG3152	Membrane
D1369_RS17500	COG0113	porphobilinogen synthase activity
D1369_RS17525	COG2319	Wd-40 repeat
D1369_RS17525	COG4249	Peptidase C14 caspase catalytic subunit p20
D1369_RS17535	COG0181	hydroxymethylbilane synthase activity
D1369_RS17540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1369_RS17545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D1369_RS17595	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1369_RS17600	COG0738	Major facilitator superfamily
D1369_RS17610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1369_RS17635	COG0180	Tryptophanyl-tRNA synthetase
D1369_RS17640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1369_RS17650	COG0842	Transport permease protein
D1369_RS17650	COG1129	ABC transporter
D1369_RS17665	COG4991	sh3 domain protein
D1369_RS17670	COG4991	sh3 domain protein
D1369_RS17675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1369_RS17675	COG0515	serine threonine protein kinase
D1369_RS17680	COG0129	dihydroxy-acid dehydratase activity
D1369_RS17685	COG1309	transcriptional regulator
D1369_RS17690	COG1082	Xylose isomerase domain protein TIM barrel
D1369_RS17695	COG0248	Ppx GppA phosphatase
D1369_RS17715	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D1369_RS17725	COG1194	a g-specific adenine glycosylase
D1369_RS17730	COG1595	DNA-templated transcription, initiation
D1369_RS17740	COG0745	RESPONSE REGULATOR receiver
D1369_RS17745	COG2205	protein histidine kinase activity
D1369_RS17750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D1369_RS17765	COG0477	Major facilitator Superfamily
D1369_RS17775	COG0739	heme binding
D1369_RS17805	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1369_RS17825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1369_RS17835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1369_RS17840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1369_RS17865	COG2197	response regulator
D1369_RS17880	COG0649	NAD binding
D1369_RS17920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1369_RS17925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1369_RS17935	COG0302	gtp cyclohydrolase
D1369_RS17950	COG0037	tRNA processing
D1369_RS17960	COG2027	D-alanyl-D-alanine carboxypeptidase
D1369_RS17965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1369_RS17975	COG0586	Pfam SNARE associated Golgi protein
D1369_RS17980	COG0393	Putative heavy-metal-binding
D1369_RS17985	COG0789	Transcriptional regulator
D1369_RS17995	COG0076	glutamate decarboxylase activity
D1369_RS18015	COG2318	DinB family
D1369_RS18020	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS18055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1369_RS18065	COG0254	rRNA binding
D1369_RS18070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1369_RS18075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1369_RS18080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1369_RS18100	COG1280	lysine exporter protein (LysE YggA)
D1369_RS18110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1369_RS18110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1369_RS18115	COG3629	intracellular signal transduction
D1369_RS18115	COG3903	Transcriptional regulator
D1369_RS18160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1369_RS18165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1369_RS18165	COG1754	DNA topoisomerase type I activity
D1369_RS18175	COG2890	protein-(glutamine-N5) methyltransferase activity
D1369_RS18185	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D1369_RS18195	COG1366	Belongs to the anti-sigma-factor antagonist family
D1369_RS18200	COG1205	dead DEAH box helicase
D1369_RS18200	COG1111	helicase
D1369_RS18260	COG0659	secondary active sulfate transmembrane transporter activity
D1369_RS18275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1369_RS18280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1369_RS18290	COG2267	carboxylic ester hydrolase activity
D1369_RS18325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1369_RS18350	COG0003	Pfam Anion-transporting ATPase
D1369_RS18370	COG1408	metallophosphoesterase
D1369_RS18385	COG1609	Transcriptional regulator
D1369_RS18405	COG1051	belongs to the nudix hydrolase family
D1369_RS18485	COG0583	DNA-binding transcription factor activity
D1369_RS18490	COG0697	spore germination
D1369_RS18500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1369_RS18505	COG0640	Transcriptional regulator
D1369_RS18510	COG4249	Peptidase C14 caspase catalytic subunit p20
D1369_RS18510	COG2319	Wd-40 repeat
D1369_RS18530	COG0701	Predicted permease
D1369_RS18560	COG1595	DNA-templated transcription, initiation
D1369_RS18575	COG0745	RESPONSE REGULATOR receiver
D1369_RS18580	COG2205	protein histidine kinase activity
D1369_RS18600	COG2315	Protein conserved in bacteria
D1369_RS18615	COG2272	Belongs to the type-B carboxylesterase lipase family
D1369_RS18630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1369_RS18635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1369_RS18655	COG0693	protein deglycase activity
D1369_RS18660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1369_RS18665	COG1802	Transcriptional regulator
D1369_RS18685	COG1595	DNA-templated transcription, initiation
D1369_RS18690	COG0737	Belongs to the 5'-nucleotidase family
D1369_RS18695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1369_RS18710	COG4303	Ethanolamine ammonia lyase large subunit
D1369_RS18725	COG1131	(ABC) transporter
D1369_RS18730	COG3559	Exporter of polyketide antibiotics
D1369_RS18765	COG0592	DNA-directed DNA polymerase activity
D1369_RS18770	COG2197	response regulator
D1369_RS18775	COG4585	Histidine kinase
D1369_RS18780	COG2197	response regulator
D1369_RS18785	COG4585	Histidine kinase
D1369_RS18810	COG3844	kynureninase activity
D1369_RS18825	COG0477	Major facilitator Superfamily
D1369_RS18830	COG0191	fructose-bisphosphate aldolase activity
D1369_RS18835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1369_RS18850	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1369_RS18895	COG0542	response to heat
D1369_RS18940	COG1305	Transglutaminase-like
D1369_RS18945	COG4213	ABC transporter substrate-binding protein
D1369_RS18955	COG0789	Transcriptional regulator
D1369_RS18960	COG0484	heat shock protein binding
D1369_RS18965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1369_RS18970	COG0443	Heat shock 70 kDa protein
D1369_RS18975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1369_RS18980	COG2181	nitrate reductase activity
D1369_RS18980	COG0247	lactate metabolic process
D1369_RS19005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1369_RS19010	COG0717	Belongs to the dCTP deaminase family
D1369_RS19105	COG1755	Isoprenylcysteine carboxyl methyltransferase
D1369_RS19140	COG1302	Protein conserved in bacteria
D1369_RS19175	COG4977	sequence-specific DNA binding
D1369_RS19225	COG2197	response regulator
D1369_RS19260	COG0662	Cupin 2, conserved barrel domain protein
D1369_RS19270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1369_RS19275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1369_RS19280	COG2867	negative regulation of translational initiation
D1369_RS19315	COG1278	Cold shock
D1369_RS19320	COG0513	Belongs to the DEAD box helicase family
D1369_RS19360	COG1278	Cold shock
D1369_RS19365	COG0513	Belongs to the DEAD box helicase family
D1369_RS19385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D1369_RS19385	COG2755	lipolytic protein G-D-S-L family
D1369_RS19410	COG4585	Histidine kinase
D1369_RS19415	COG2409	Drug exporters of the RND superfamily
D1369_RS19435	COG0135	phosphoribosylanthranilate isomerase activity
D1369_RS19470	COG2197	response regulator
D1369_RS19475	COG4585	Histidine kinase
D1369_RS19480	COG4213	ABC transporter substrate-binding protein
D1369_RS19515	COG0366	Alpha amylase catalytic
D1369_RS19545	COG0640	Transcriptional regulator
D1369_RS19550	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1369_RS19555	COG1957	nucleoside hydrolase
D1369_RS19560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1369_RS19630	COG1396	sequence-specific DNA binding
D1369_RS19665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1369_RS19670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1369_RS19685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1369_RS19695	COG3866	Pectate lyase
D1369_RS19710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1369_RS19725	COG1741	Belongs to the pirin family
D1369_RS19730	COG0477	Major facilitator Superfamily
D1369_RS19750	COG1960	acyl-CoA dehydrogenase activity
D1369_RS19755	COG1362	aminopeptidase activity
D1369_RS19775	COG0662	Cupin 2, conserved barrel domain protein
D1369_RS19800	COG2814	Major facilitator Superfamily
D1369_RS19815	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1369_RS19820	COG0022	dehydrogenase e1 component
D1369_RS19835	COG0515	serine threonine protein kinase
D1369_RS19850	COG3321	synthase
D1369_RS19850	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS19850	COG0604	alcohol dehydrogenase
D1369_RS19865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1369_RS19895	COG1522	sequence-specific DNA binding
D1369_RS19900	COG1309	transcriptional regulator
D1369_RS19905	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS19930	COG3396	Phenylacetate-CoA oxygenase
D1369_RS19935	COG3460	Phenylacetate-CoA oxygenase
D1369_RS19940	COG3396	Phenylacetate-CoA oxygenase
D1369_RS19945	COG2151	metal-sulfur cluster biosynthetic enzyme
D1369_RS19950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1369_RS19975	COG2197	response regulator
D1369_RS19990	COG0577	efflux transmembrane transporter activity
D1369_RS19990	COG1136	(ABC) transporter
D1369_RS19995	COG0577	efflux transmembrane transporter activity
D1369_RS20015	COG0529	Catalyzes the synthesis of activated sulfate
D1369_RS20020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1369_RS20025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1369_RS20035	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS20040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1369_RS20050	COG0657	acetylesterase activity
D1369_RS20085	COG0006	proline dipeptidase activity
D1369_RS20115	COG2030	dehydratase
D1369_RS20120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1369_RS20135	COG3958	Transketolase
D1369_RS20140	COG3959	Transketolase, thiamine diphosphate binding domain
D1369_RS20145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1369_RS20165	COG0189	ligase activity
D1369_RS20170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1369_RS20190	COG2197	response regulator
D1369_RS20230	COG1716	ATPase activity
D1369_RS20235	COG1716	ATPase activity
D1369_RS20250	COG0768	penicillin binding
D1369_RS20260	COG0515	serine threonine protein kinase
D1369_RS20270	COG3764	Sortase (surface protein transpeptidase)
D1369_RS20275	COG3764	Sortase (surface protein transpeptidase)
D1369_RS20290	COG3764	Sortase (surface protein transpeptidase)
D1369_RS20305	COG0705	Rhomboid family
D1369_RS20370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1369_RS20375	COG0187	DNA topoisomerase II activity
D1369_RS20380	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D1369_RS20385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1369_RS20390	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1369_RS20395	COG0592	DNA-directed DNA polymerase activity
D1369_RS20405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1369_RS20415	COG0594	ribonuclease P activity
D1369_RS20420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1369_RS20425	COG0706	membrane insertase activity
D1369_RS20435	COG0357	Ribosomal RNA small subunit methyltransferase G
D1369_RS20440	COG1192	Involved in chromosome partitioning
D1369_RS20455	COG3118	belongs to the thioredoxin family
D1369_RS20460	COG0492	ferredoxin-NADP+ reductase activity
D1369_RS20470	COG1595	DNA-templated transcription, initiation
D1369_RS20475	COG0515	serine threonine protein kinase
D1369_RS20475	COG2815	serine threonine protein kinase
D1369_RS20490	COG0617	tRNA 3'-terminal CCA addition
D1369_RS20510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1369_RS20545	COG0360	Binds together with S18 to 16S ribosomal RNA
D1369_RS20550	COG0629	single-stranded DNA binding
D1369_RS20555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1369_RS20560	COG0359	binds to the 23S rRNA
D1369_RS20570	COG0305	Participates in initiation and elongation during chromosome replication
D1369_RS20580	COG1309	transcriptional regulator
D1369_RS20605	COG2814	Major facilitator Superfamily
D1369_RS20635	COG0626	cystathionine gamma-synthase activity
D1369_RS20640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1369_RS20645	COG1950	PFAM Membrane protein of
D1369_RS20650	COG0662	Cupin 2, conserved barrel domain protein
D1369_RS20675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1369_RS20690	COG1609	Transcriptional regulator
D1369_RS20695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1369_RS20700	COG1271	oxidase subunit
D1369_RS20705	COG1294	oxidase, subunit
D1369_RS20710	COG4988	ABC transporter
D1369_RS20715	COG0741	lytic transglycosylase activity
D1369_RS20715	COG1196	nuclear chromosome segregation
D1369_RS20715	COG0739	heme binding
D1369_RS20720	COG0561	phosphatase activity
D1369_RS20735	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D1369_RS20740	COG0789	Transcriptional regulator
D1369_RS20765	COG1131	(ABC) transporter
D1369_RS20795	COG0561	phosphatase activity
D1369_RS20800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1369_RS20805	COG0077	Prephenate dehydratase
D1369_RS20810	COG2837	iron assimilation
D1369_RS20825	COG1999	signal sequence binding
D1369_RS20860	COG0641	radical SAM
D1369_RS20875	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D1369_RS20885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1369_RS20890	COG0006	proline dipeptidase activity
D1369_RS20910	COG0653	protein targeting
D1369_RS20930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1369_RS21000	COG0542	response to heat
D1369_RS21015	COG2746	aminoglycoside 3-N-acetyltransferase activity
D1369_RS21050	COG1595	DNA-templated transcription, initiation
D1369_RS21055	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS21060	COG2814	Major facilitator Superfamily
D1369_RS21065	COG1309	transcriptional regulator
D1369_RS21140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1369_RS21150	COG1846	Transcriptional regulator
D1369_RS21170	COG0745	RESPONSE REGULATOR receiver
D1369_RS21175	COG2205	protein histidine kinase activity
D1369_RS21185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1369_RS21190	COG0477	Major facilitator Superfamily
D1369_RS21200	COG3467	pyridoxamine 5'-phosphate
D1369_RS21210	COG2353	YceI-like domain
D1369_RS21215	COG0477	Major facilitator Superfamily
D1369_RS21230	COG1191	sigma factor activity
D1369_RS21235	COG1191	sigma factor activity
D1369_RS21265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1369_RS21280	COG0433	COG0433 Predicted ATPase
D1369_RS21320	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS21405	COG0151	Belongs to the GarS family
D1369_RS21420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1369_RS21430	COG2197	response regulator
D1369_RS21465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1369_RS21470	COG0047	phosphoribosylformylglycinamidine synthase activity
D1369_RS21475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1369_RS21495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1369_RS21505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1369_RS21530	COG1643	Atp-dependent helicase
D1369_RS21565	COG0513	Belongs to the DEAD box helicase family
D1369_RS21585	COG1302	Protein conserved in bacteria
D1369_RS21625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1369_RS21625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1369_RS21635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1369_RS21650	COG0667	Aldo Keto reductase
D1369_RS21660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1369_RS21665	COG0579	oxidoreductase
D1369_RS21685	COG1470	cell adhesion involved in biofilm formation
D1369_RS21685	COG0366	Alpha amylase catalytic
D1369_RS21695	COG1252	NADH dehydrogenase
D1369_RS21780	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS21785	COG0596	Alpha beta hydrolase
D1369_RS21795	COG1196	nuclear chromosome segregation
D1369_RS21795	COG0741	lytic transglycosylase activity
D1369_RS21795	COG0739	heme binding
D1369_RS21800	COG0671	phosphoesterase, PA-phosphatase related
D1369_RS21805	COG0277	FAD linked oxidase domain protein
D1369_RS21825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1369_RS21830	COG0306	phosphate transporter
D1369_RS21840	COG1937	Protein conserved in bacteria
D1369_RS21855	COG0494	nUDIX hydrolase
D1369_RS21855	COG0406	alpha-ribazole phosphatase activity
D1369_RS21865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1369_RS21885	COG1131	(ABC) transporter
D1369_RS21905	COG0456	acetyltransferase
D1369_RS21910	COG0737	Belongs to the 5'-nucleotidase family
D1369_RS21920	COG1132	(ABC) transporter
D1369_RS21950	COG0745	RESPONSE REGULATOR receiver
D1369_RS21960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1369_RS21965	COG1609	Transcriptional regulator
D1369_RS21970	COG0745	RESPONSE REGULATOR receiver
D1369_RS22000	COG2897	thiosulfate sulfurtransferase activity
D1369_RS22035	COG3485	protocatechuate 3,4-dioxygenase
D1369_RS22040	COG0735	belongs to the Fur family
D1369_RS22045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1369_RS22050	COG1490	D-aminoacyl-tRNA deacylase activity
D1369_RS22070	COG2188	Transcriptional regulator
D1369_RS22080	COG2188	Transcriptional regulator
D1369_RS22085	COG0546	phosphoglycolate phosphatase activity
D1369_RS22110	COG3973	AAA domain
D1369_RS22120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1369_RS22145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1369_RS22155	COG0640	Transcriptional regulator
D1369_RS22195	COG0438	transferase activity, transferring glycosyl groups
D1369_RS22220	COG0588	phosphoglycerate mutase activity
D1369_RS22240	COG5002	protein histidine kinase activity
D1369_RS22260	COG1329	Transcriptional regulator
D1369_RS22265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1369_RS22270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1369_RS22275	COG0215	cysteine-tRNA ligase activity
D1369_RS22290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1369_RS22300	COG3842	ATPase activity
D1369_RS22310	COG2205	protein histidine kinase activity
D1369_RS22315	COG0745	RESPONSE REGULATOR receiver
D1369_RS22450	COG5001	Diguanylate cyclase
D1369_RS22450	COG3300	MHYT domain
D1369_RS22470	COG1105	Belongs to the carbohydrate kinase PfkB family
D1369_RS22500	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D1369_RS22505	COG0463	Glycosyl transferase, family 2
D1369_RS22520	COG1278	Cold shock
D1369_RS22525	COG0459	protein refolding
D1369_RS22545	COG2318	DinB family
D1369_RS22565	COG4106	trans-aconitate 2-methyltransferase activity
D1369_RS22575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1369_RS22580	COG1737	Transcriptional regulator
D1369_RS22615	COG3973	AAA domain
D1369_RS22625	COG1061	Type III restriction enzyme res subunit
D1369_RS22680	COG1278	Cold shock
D1369_RS22690	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1369_RS22695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1369_RS22705	COG2814	Major facilitator Superfamily
D1369_RS22720	COG1595	DNA-templated transcription, initiation
D1369_RS22740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1369_RS22750	COG2252	PERMEase
D1369_RS22760	COG1846	Transcriptional regulator
D1369_RS22780	COG0667	Aldo Keto reductase
D1369_RS22790	COG0154	amidase activity
D1369_RS22835	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1369_RS22840	COG0596	Alpha beta hydrolase
D1369_RS22845	COG1733	regulation of RNA biosynthetic process
D1369_RS22855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1369_RS22860	COG0247	lactate metabolic process
D1369_RS22860	COG0277	FAD linked oxidase domain protein
D1369_RS22880	COG5006	permease, DMT superfamily
D1369_RS22885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1369_RS22900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1369_RS22915	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS22930	COG0259	pyridoxamine-phosphate oxidase activity
D1369_RS22955	COG4821	SIS domain
D1369_RS22965	COG0596	Alpha beta hydrolase
D1369_RS22965	COG2945	thiolester hydrolase activity
D1369_RS23030	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS23035	COG1960	acyl-CoA dehydrogenase activity
D1369_RS23040	COG1960	acyl-CoA dehydrogenase activity
D1369_RS23060	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS23065	COG1960	acyl-CoA dehydrogenase activity
D1369_RS23080	COG2814	Major facilitator Superfamily
D1369_RS23100	COG1024	Enoyl-CoA hydratase
D1369_RS23110	COG1231	oxidoreductase activity
D1369_RS23115	COG2072	flavoprotein involved in K transport
D1369_RS23150	COG0259	pyridoxamine-phosphate oxidase activity
D1369_RS23170	COG1960	acyl-CoA dehydrogenase activity
D1369_RS23180	COG1309	transcriptional regulator
D1369_RS23195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1369_RS23195	COG0515	serine threonine protein kinase
D1369_RS23205	COG0596	Alpha beta hydrolase
D1369_RS23210	COG1024	Enoyl-CoA hydratase
D1369_RS23260	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS23275	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS23290	COG3321	synthase
D1369_RS23290	COG0604	alcohol dehydrogenase
D1369_RS23290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS23290	COG4221	oxidoreductase activity
D1369_RS23355	COG3479	Phenolic acid decarboxylase
D1369_RS23370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1369_RS23415	COG1686	Belongs to the peptidase S11 family
D1369_RS23435	COG0386	Belongs to the glutathione peroxidase family
D1369_RS23470	COG3973	AAA domain
D1369_RS23490	COG3263	regulation of cellular component size
D1369_RS23500	COG3387	PFAM Glycoside hydrolase 15-related
D1369_RS23510	COG3265	gluconokinase activity
D1369_RS23520	COG1294	oxidase, subunit
D1369_RS23525	COG1271	oxidase subunit
D1369_RS23535	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS23555	COG1404	Belongs to the peptidase S8 family
D1369_RS23570	COG1414	Transcriptional regulator
D1369_RS23590	COG1846	Transcriptional regulator
D1369_RS23595	COG3384	dioxygenase
D1369_RS23600	COG1247	-acetyltransferase
D1369_RS23615	COG0477	Major facilitator Superfamily
D1369_RS23620	COG1349	DNA-binding transcription factor activity
D1369_RS23630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1369_RS23630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1369_RS23645	COG1376	ErfK ybiS ycfS ynhG family protein
D1369_RS23670	COG1970	mechanosensitive ion channel activity
D1369_RS23680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1369_RS23705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1369_RS23710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1369_RS23720	COG0315	cyclic pyranopterin monophosphate synthase activity
D1369_RS23725	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1369_RS23725	COG0315	cyclic pyranopterin monophosphate synthase activity
D1369_RS23730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1369_RS23750	COG0708	Exodeoxyribonuclease III
D1369_RS23760	COG2072	flavoprotein involved in K transport
D1369_RS23765	COG2267	carboxylic ester hydrolase activity
D1369_RS23770	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS23780	COG4946	Tricorn protease homolog
D1369_RS23780	COG0793	Belongs to the peptidase S41A family
D1369_RS23790	COG2409	Drug exporters of the RND superfamily
D1369_RS23795	COG0456	acetyltransferase
D1369_RS23800	COG0442	prolyl-tRNA aminoacylation
D1369_RS23810	COG1131	(ABC) transporter
D1369_RS23830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1369_RS23835	COG1764	response to oxidative stress
D1369_RS23840	COG1846	Transcriptional regulator
D1369_RS23845	COG1122	ATPase activity
D1369_RS23855	COG0310	cobalt ion transport
D1369_RS23865	COG0768	penicillin binding
D1369_RS23890	COG0084	hydrolase, TatD family'
D1369_RS23895	COG3583	domain protein
D1369_RS23895	COG3584	3D domain protein
D1369_RS23900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1369_RS23905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1369_RS23910	COG0488	(ABC) transporter
D1369_RS23940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1369_RS23955	COG2197	response regulator
D1369_RS23965	COG4106	trans-aconitate 2-methyltransferase activity
D1369_RS23990	COG1309	transcriptional regulator
D1369_RS24000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1369_RS24015	COG0193	aminoacyl-tRNA hydrolase activity
D1369_RS24020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1369_RS24025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1369_RS24030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1369_RS24040	COG4585	Histidine kinase
D1369_RS24070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1369_RS24080	COG0477	Major facilitator Superfamily
D1369_RS24085	COG1136	(ABC) transporter
D1369_RS24090	COG0577	efflux transmembrane transporter activity
D1369_RS24135	COG2801	Transposase and inactivated derivatives
D1369_RS24240	COG2124	cytochrome p450
D1369_RS24255	COG0148	phosphopyruvate hydratase activity
D1369_RS24275	COG1252	NADH dehydrogenase
D1369_RS24280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1369_RS24285	COG0577	efflux transmembrane transporter activity
D1369_RS24290	COG1136	(ABC) transporter
D1369_RS24360	COG0183	Belongs to the thiolase family
D1369_RS24365	COG2755	lipolytic protein G-D-S-L family
D1369_RS24380	COG4221	oxidoreductase activity
D1369_RS24395	COG1174	glycine betaine transport
D1369_RS24400	COG1174	glycine betaine transport
D1369_RS24405	COG0517	IMP dehydrogenase activity
D1369_RS24405	COG1125	glycine betaine transport
D1369_RS24450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1369_RS24455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1369_RS24465	COG1228	amidohydrolase
D1369_RS24475	COG1191	sigma factor activity
D1369_RS24480	COG1366	Belongs to the anti-sigma-factor antagonist family
D1369_RS24505	COG3104	oligopeptide transport
D1369_RS24510	COG0745	RESPONSE REGULATOR receiver
D1369_RS24515	COG2205	protein histidine kinase activity
D1369_RS24575	COG1276	copper resistance
D1369_RS24585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1369_RS24605	COG1316	TRANSCRIPTIONal
D1369_RS24620	COG1316	TRANSCRIPTIONal
D1369_RS24635	COG1316	TRANSCRIPTIONal
D1369_RS24640	COG1316	TRANSCRIPTIONal
D1369_RS24645	COG1316	TRANSCRIPTIONal
D1369_RS24650	COG1316	TRANSCRIPTIONal
D1369_RS24675	COG0778	Nitroreductase
D1369_RS24675	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D1369_RS24680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1369_RS24720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1369_RS24725	COG2835	tetraacyldisaccharide 4'-kinase activity
D1369_RS24735	COG1482	cell wall glycoprotein biosynthetic process
D1369_RS24750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1369_RS24795	COG0714	Associated with various cellular activities
D1369_RS24815	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1369_RS24820	COG0745	RESPONSE REGULATOR receiver
D1369_RS24825	COG5002	protein histidine kinase activity
D1369_RS24830	COG0823	Involved in the tonB-independent uptake of proteins
D1369_RS24845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1369_RS24850	COG2197	response regulator
D1369_RS24855	COG3214	Protein conserved in bacteria
D1369_RS24865	COG0653	protein targeting
D1369_RS24890	COG2902	Dehydrogenase
D1369_RS24895	COG1134	teichoic acid transport
D1369_RS24915	COG1764	response to oxidative stress
D1369_RS24920	COG1846	Transcriptional regulator
D1369_RS24930	COG1216	Glycosyl transferase, family 2
D1369_RS24935	COG0395	ABC-type sugar transport system, permease component
D1369_RS24940	COG1175	transmembrane transport
D1369_RS24955	COG0515	serine threonine protein kinase
D1369_RS24960	COG0515	serine threonine protein kinase
D1369_RS24965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1369_RS24980	COG2884	Cell division ATP-binding protein ftsE
D1369_RS24985	COG2177	Part of the ABC transporter FtsEX involved in
D1369_RS24990	COG0793	Belongs to the peptidase S41A family
D1369_RS24995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1369_RS25010	COG1501	Belongs to the glycosyl hydrolase 31 family
D1369_RS25015	COG0395	ABC-type sugar transport system, permease component
D1369_RS25020	COG1175	transmembrane transport
D1369_RS25035	COG0583	DNA-binding transcription factor activity
D1369_RS25065	COG2223	nitrite transmembrane transporter activity
D1369_RS25095	COG3973	AAA domain
D1369_RS25095	COG3973	AAA domain
D1369_RS25105	COG0776	regulation of translation
D1369_RS25110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1369_RS25115	COG1678	Uncharacterized ACR, COG1678
D1369_RS25130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1369_RS25160	COG4044	May play a role in the intracellular transport of hydrophobic ligands
D1369_RS25205	COG1174	glycine betaine transport
D1369_RS25215	COG1174	glycine betaine transport
D1369_RS25225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1369_RS25255	COG0277	FAD linked oxidase domain protein
D1369_RS25290	COG1335	isochorismatase
D1369_RS25300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1369_RS25310	COG1113	amino acid transport
D1369_RS25350	COG1263	PTS System
D1369_RS25355	COG1263	PTS System
D1369_RS25360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1369_RS25365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1369_RS25375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1369_RS25410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1369_RS25425	COG4555	ABC transporter
D1369_RS25440	COG2733	membrane
D1369_RS25585	COG3764	Sortase (surface protein transpeptidase)
D1369_RS25620	COG4702	Belongs to the UPF0303 family
D1369_RS25625	COG0673	inositol 2-dehydrogenase activity
D1369_RS25695	COG3397	chitin binding
D1369_RS25705	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS25720	COG1126	abc transporter atp-binding protein
D1369_RS25725	COG0765	amino acid transport
D1369_RS25730	COG0765	amino acid transport
D1369_RS25735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1369_RS25770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS25820	COG0406	alpha-ribazole phosphatase activity
D1369_RS25845	COG0745	RESPONSE REGULATOR receiver
D1369_RS25855	COG3979	chitinase
D1369_RS25860	COG1653	transport
D1369_RS25865	COG1175	transmembrane transport
D1369_RS25870	COG0395	ABC-type sugar transport system, permease component
D1369_RS25875	COG3345	alpha-galactosidase
D1369_RS25900	COG1487	ribonuclease activity
D1369_RS25910	COG0395	ABC-type sugar transport system, permease component
D1369_RS25940	COG0583	DNA-binding transcription factor activity
D1369_RS25950	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1369_RS25955	COG4977	sequence-specific DNA binding
D1369_RS25965	COG0589	response to stress
D1369_RS25970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1369_RS26005	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1369_RS26025	COG1960	acyl-CoA dehydrogenase activity
D1369_RS26040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1369_RS26045	COG1309	transcriptional regulator
D1369_RS26055	COG1946	Acyl-CoA thioesterase
D1369_RS26070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1369_RS26080	COG0028	Belongs to the TPP enzyme family
D1369_RS26085	COG2356	endonuclease I
D1369_RS26100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1369_RS26135	COG1472	Belongs to the glycosyl hydrolase 3 family
D1369_RS26145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1369_RS26185	COG0456	acetyltransferase
D1369_RS26185	COG1846	Transcriptional regulator
D1369_RS26225	COG0673	inositol 2-dehydrogenase activity
D1369_RS26240	COG1869	D-ribose catabolic process
D1369_RS26245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS26255	COG1129	ABC transporter
D1369_RS26265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1369_RS26290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1369_RS26310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS26320	COG3718	enzyme involved in inositol metabolism
D1369_RS26325	COG3962	Belongs to the TPP enzyme family
D1369_RS26340	COG1131	(ABC) transporter
D1369_RS26415	COG0728	peptidoglycan biosynthetic process
D1369_RS26425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1369_RS26430	COG0438	transferase activity, transferring glycosyl groups
D1369_RS26475	COG2304	oxidoreductase activity
D1369_RS26485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1369_RS26510	COG2188	Transcriptional regulator
D1369_RS26590	COG0629	single-stranded DNA binding
D1369_RS26630	COG0577	efflux transmembrane transporter activity
D1369_RS26630	COG1136	(ABC) transporter
D1369_RS26645	COG2346	COG2346, Truncated hemoglobins
D1369_RS26700	COG1486	melibiose metabolic process
D1369_RS26705	COG0395	ABC-type sugar transport system, permease component
D1369_RS26710	COG1175	transmembrane transport
D1369_RS26715	COG1653	transport
D1369_RS26720	COG1940	carbohydrate kinase activity
D1369_RS26730	COG0668	transmembrane transport
D1369_RS26745	COG1136	(ABC) transporter
D1369_RS26775	COG1846	Transcriptional regulator
D1369_RS26780	COG0697	spore germination
D1369_RS26875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1369_RS26885	COG1070	Carbohydrate kinase
D1369_RS26910	COG1113	amino acid transport
D1369_RS26920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS26925	COG1116	anion transmembrane transporter activity
D1369_RS26930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1369_RS26940	COG1940	carbohydrate kinase activity
D1369_RS26965	COG1113	amino acid transport
D1369_RS26970	COG0698	ribose 5-phosphate isomerase
D1369_RS26980	COG4552	Acetyltransferase involved in intracellular survival and related
D1369_RS27000	COG3594	Acyltransferase
D1369_RS27020	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1369_RS27025	COG0740	serine-type endopeptidase activity
D1369_RS27030	COG0740	serine-type endopeptidase activity
D1369_RS27035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1369_RS27045	COG0525	valine-tRNA ligase activity
D1369_RS27050	COG0285	dihydrofolate synthase activity
D1369_RS27060	COG0105	UTP biosynthetic process
D1369_RS27065	COG1077	Cell shape determining protein MreB Mrl
D1369_RS27080	COG0768	penicillin binding
D1369_RS27085	COG0772	Belongs to the SEDS family
D1369_RS27105	COG0539	negative regulation of cytoplasmic translation
D1369_RS27150	COG1530	ribonuclease E activity
D1369_RS27180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1369_RS27185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1369_RS27190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1369_RS27200	COG3540	Alkaline phosphatase
D1369_RS27220	COG1216	Glycosyl transferase, family 2
D1369_RS27235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1369_RS27250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1369_RS27265	COG0501	Belongs to the peptidase M48B family
D1369_RS27270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1369_RS27280	COG0799	negative regulation of ribosome biogenesis
D1369_RS27285	COG0588	phosphoglycerate mutase activity
D1369_RS27315	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1369_RS27325	COG0495	leucyl-tRNA aminoacylation
D1369_RS27335	COG1307	EDD domain protein, DegV family
D1369_RS27345	COG1555	photosystem II stabilization
D1369_RS27345	COG1596	polysaccharide export
D1369_RS27350	COG1234	tRNA 3'-trailer cleavage
D1369_RS27375	COG0268	Binds directly to 16S ribosomal RNA
D1369_RS27385	COG0481	GTPase activity
D1369_RS27425	COG1420	regulation of RNA biosynthetic process
D1369_RS27430	COG0484	heat shock protein binding
D1369_RS27455	COG0793	Belongs to the peptidase S41A family
D1369_RS27455	COG4946	Tricorn protease homolog
D1369_RS27460	COG0537	adenosine 5'-monophosphoramidase activity
D1369_RS27465	COG1234	tRNA 3'-trailer cleavage
D1369_RS27470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1369_RS27485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS27490	COG4948	Mandelate Racemase Muconate Lactonizing
D1369_RS27495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS27510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1369_RS27520	COG2315	Protein conserved in bacteria
D1369_RS27565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1369_RS27605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1369_RS27615	COG2409	Drug exporters of the RND superfamily
D1369_RS27620	COG4585	Histidine kinase
D1369_RS27625	COG2197	response regulator
D1369_RS27630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS27675	COG1381	Involved in DNA repair and RecF pathway recombination
D1369_RS27680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1369_RS27695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1369_RS27700	COG1121	(ABC) transporter
D1369_RS27705	COG3443	Belongs to the bacterial solute-binding protein 9 family
D1369_RS27705	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1369_RS27710	COG0423	glycine-tRNA ligase activity
D1369_RS27720	COG0667	Aldo Keto reductase
D1369_RS27735	COG0477	Major facilitator Superfamily
D1369_RS27750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1369_RS27780	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D1369_RS27785	COG1940	carbohydrate kinase activity
D1369_RS27785	COG1846	Transcriptional regulator
D1369_RS27790	COG0574	Belongs to the PEP-utilizing enzyme family
D1369_RS27790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1369_RS27830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1369_RS27830	COG2146	nitrite reductase [NAD(P)H] activity
D1369_RS27835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1369_RS27840	COG3896	Chloramphenicol phosphotransferase-like protein
D1369_RS27875	COG0243	molybdopterin cofactor binding
D1369_RS27880	COG4991	sh3 domain protein
D1369_RS27885	COG2949	membrane
D1369_RS27895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1369_RS27905	COG0358	DNA primase activity
D1369_RS27910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1369_RS27925	COG1070	Carbohydrate kinase
D1369_RS27965	COG2267	carboxylic ester hydrolase activity
D1369_RS27970	COG1309	transcriptional regulator
D1369_RS27995	COG1301	dicarboxylic acid transport
D1369_RS28000	COG2828	Protein conserved in bacteria
D1369_RS28040	COG1902	pentaerythritol trinitrate reductase activity
D1369_RS28080	COG0411	ABC transporter
D1369_RS28100	COG1191	sigma factor activity
D1369_RS28150	COG1077	Cell shape determining protein MreB Mrl
D1369_RS28155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1369_RS28155	COG0825	malonyl-CoA metabolic process
D1369_RS28160	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS28180	COG2835	tetraacyldisaccharide 4'-kinase activity
D1369_RS28200	COG4981	capsule polysaccharide biosynthetic process
D1369_RS28230	COG1414	Transcriptional regulator
D1369_RS28235	COG3386	PFAM SMP-30 Gluconolaconase
D1369_RS28260	COG1175	transmembrane transport
D1369_RS28265	COG0395	ABC-type sugar transport system, permease component
D1369_RS28335	COG3507	Belongs to the glycosyl hydrolase 43 family
D1369_RS28340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1369_RS28350	COG4214	carbohydrate transport
D1369_RS28355	COG1129	ABC transporter
D1369_RS28375	COG4948	Mandelate Racemase Muconate Lactonizing
D1369_RS28380	COG1609	Transcriptional regulator
D1369_RS28385	COG1879	ABC-type sugar transport system periplasmic component
D1369_RS28395	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1369_RS28400	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1369_RS28415	COG2130	NADP-dependent
D1369_RS28420	COG1764	response to oxidative stress
D1369_RS28480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1369_RS28485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1369_RS28490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1369_RS28505	COG1741	Belongs to the pirin family
D1369_RS28520	COG0789	Transcriptional regulator
D1369_RS28525	COG0667	Aldo Keto reductase
D1369_RS28540	COG1309	transcriptional regulator
D1369_RS28545	COG0477	Major facilitator Superfamily
D1369_RS28555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1369_RS28560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1369_RS28605	COG1358	cellular component organization or biogenesis
D1369_RS28625	COG3540	Alkaline phosphatase
D1369_RS28700	COG2814	Major facilitator Superfamily
D1369_RS28710	COG2267	carboxylic ester hydrolase activity
D1369_RS28735	COG2259	Doxx family
D1369_RS28790	COG4122	O-methyltransferase activity
D1369_RS28805	COG2124	cytochrome p450
D1369_RS28810	COG0183	Belongs to the thiolase family
D1369_RS28815	COG3903	Transcriptional regulator
D1369_RS28815	COG3629	intracellular signal transduction
D1369_RS28820	COG2267	carboxylic ester hydrolase activity
D1369_RS28825	COG3619	membrane
D1369_RS28845	COG3845	ABC transporter
D1369_RS28880	COG1309	transcriptional regulator
D1369_RS28885	COG0438	transferase activity, transferring glycosyl groups
D1369_RS28905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS28915	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1369_RS28925	COG0477	Major facilitator Superfamily
D1369_RS28935	COG2197	response regulator
D1369_RS28940	COG4585	Histidine kinase
D1369_RS28950	COG2030	dehydratase
D1369_RS28960	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS28970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1369_RS28985	COG0800	Aldolase
D1369_RS28990	COG3022	response to hydroperoxide
D1369_RS28995	COG0557	exoribonuclease II activity
D1369_RS29050	COG1175	transmembrane transport
D1369_RS29055	COG0395	ABC-type sugar transport system, permease component
D1369_RS29065	COG1940	carbohydrate kinase activity
D1369_RS29095	COG3835	regulator
D1369_RS29100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1369_RS29105	COG0765	amino acid transport
D1369_RS29110	COG1126	abc transporter atp-binding protein
D1369_RS29115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1369_RS29145	COG1136	(ABC) transporter
D1369_RS29165	COG2814	Major facilitator Superfamily
D1369_RS29170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1369_RS29195	COG0672	)-iron permease
D1369_RS29200	COG2837	iron assimilation
D1369_RS29245	COG1994	Peptidase M50
D1369_RS29285	COG2814	Major facilitator Superfamily
D1369_RS29300	COG0477	Major facilitator Superfamily
D1369_RS29305	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1369_RS29335	COG0174	glutamine synthetase
D1369_RS29340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1369_RS29355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1369_RS29365	COG1609	Transcriptional regulator
D1369_RS29370	COG1653	transport
D1369_RS29375	COG1175	transmembrane transport
D1369_RS29380	COG3833	ABC-type maltose transport systems, permease component
D1369_RS29385	COG0366	Alpha amylase catalytic
D1369_RS29420	COG1309	transcriptional regulator
D1369_RS29445	COG2197	response regulator
D1369_RS29465	COG0745	RESPONSE REGULATOR receiver
D1369_RS29520	COG0501	Belongs to the peptidase M48B family
D1369_RS29535	COG0174	glutamine synthetase
D1369_RS29560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1369_RS29565	COG0321	lipoyl(octanoyl) transferase activity
D1369_RS29620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1369_RS29640	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1369_RS29645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1369_RS29655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1369_RS29665	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1369_RS29680	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D1369_RS29680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1369_RS29685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1369_RS29710	COG2226	methyltransferase
D1369_RS29730	COG4585	Histidine kinase
D1369_RS29735	COG2197	response regulator
D1369_RS29740	COG3795	YCII-related domain
D1369_RS29745	COG4941	Belongs to the sigma-70 factor family
D1369_RS29750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1369_RS29750	COG0515	serine threonine protein kinase
D1369_RS29755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1369_RS29780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS29795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1369_RS29800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1369_RS29810	COG1376	ErfK ybiS ycfS ynhG family protein
D1369_RS29820	COG1845	cytochrome c oxidase, subunit III
D1369_RS29825	COG2010	Cytochrome c
D1369_RS29830	COG0723	plastoquinol--plastocyanin reductase activity
D1369_RS29835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1369_RS29840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1369_RS29845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1369_RS29850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1369_RS29850	COG0515	serine threonine protein kinase
D1369_RS29895	COG0534	Mate efflux family protein
D1369_RS29930	COG0003	Pfam Anion-transporting ATPase
D1369_RS29940	COG1940	carbohydrate kinase activity
D1369_RS29970	COG2197	response regulator
D1369_RS29975	COG0205	6-phosphofructokinase activity
D1369_RS29990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1369_RS29995	COG0243	molybdopterin cofactor binding
D1369_RS30000	COG2193	ferroxidase activity
D1369_RS30005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1369_RS30015	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D1369_RS30020	COG0515	serine threonine protein kinase
D1369_RS30020	COG2815	serine threonine protein kinase
D1369_RS30025	COG2022	thiamine diphosphate biosynthetic process
D1369_RS30035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1369_RS30035	COG2022	thiamine diphosphate biosynthetic process
D1369_RS30055	COG0352	thiamine-phosphate diphosphorylase activity
D1369_RS30080	COG1309	transcriptional regulator
D1369_RS30090	COG1129	ABC transporter
D1369_RS30120	COG0714	Associated with various cellular activities
D1369_RS30130	COG0275	rRNA processing
D1369_RS30145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1369_RS30155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1369_RS30160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1369_RS30170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1369_RS30175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1369_RS30180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1369_RS30185	COG1496	oxidoreductase activity
D1369_RS30195	COG1799	cell septum assembly
D1369_RS30205	COG3599	regulation of cell shape
D1369_RS30210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1369_RS30225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1369_RS30235	COG2153	protein acetylation
D1369_RS30280	COG0587	DNA-directed DNA polymerase activity
D1369_RS30285	COG1432	Conserved Protein
D1369_RS30305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1369_RS30325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1369_RS30330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1369_RS30335	COG0131	Imidazoleglycerol-phosphate dehydratase
D1369_RS30340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1369_RS30345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1369_RS30350	COG0251	oxidation-reduction process
D1369_RS30355	COG0107	imidazoleglycerol-phosphate synthase activity
D1369_RS30375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1369_RS30380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1369_RS30400	COG0134	indole-3-glycerol-phosphate synthase activity
D1369_RS30405	COG0133	tryptophan synthase activity
D1369_RS30410	COG0159	tryptophan synthase activity
D1369_RS30420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1369_RS30425	COG2301	Belongs to the HpcH HpaI aldolase family
D1369_RS30430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS30435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1369_RS30455	COG1397	ADP-ribosylglycohydrolase
D1369_RS30465	COG0067	glutamate synthase
D1369_RS30465	COG0069	glutamate synthase activity
D1369_RS30465	COG0070	glutamate synthase
D1369_RS30485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1369_RS30495	COG1960	acyl-CoA dehydrogenase activity
D1369_RS30500	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS30505	COG1309	transcriptional regulator
D1369_RS30510	COG0183	Belongs to the thiolase family
D1369_RS30530	COG1024	Enoyl-CoA hydratase
D1369_RS30535	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS30540	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS30560	COG1605	Chorismate mutase
D1369_RS30560	COG0287	Prephenate dehydrogenase
D1369_RS30565	COG4566	intracellular signal transduction
D1369_RS30585	COG0737	Belongs to the 5'-nucleotidase family
D1369_RS30645	COG2050	protein possibly involved in aromatic compounds catabolism
D1369_RS30695	COG1643	Atp-dependent helicase
D1369_RS30715	COG0237	dephospho-CoA kinase activity
D1369_RS30755	COG1802	Transcriptional regulator
D1369_RS30760	COG1953	Uracil, thiamine, allantoin
D1369_RS30805	COG1132	(ABC) transporter
D1369_RS30830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1369_RS30835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1369_RS30865	COG0598	Magnesium transport protein CorA
D1369_RS30870	COG2226	methyltransferase
D1369_RS30880	COG2313	pseudouridylate synthase activity
D1369_RS30890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1369_RS30895	COG0584	glycerophosphoryl diester phosphodiesterase
D1369_RS30905	COG0556	nucleotide-excision repair
D1369_RS30930	COG0387	Pfam Sodium calcium exchanger
D1369_RS30935	COG0477	Major facilitator Superfamily
D1369_RS30945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1369_RS30955	COG0765	amino acid transport
D1369_RS30960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1369_RS31015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1369_RS31035	COG0322	excinuclease ABC activity
D1369_RS31040	COG1660	Displays ATPase and GTPase activities
D1369_RS31045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1369_RS31050	COG1481	regulation of sporulation
D1369_RS31060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1369_RS31065	COG0126	phosphoglycerate kinase activity
D1369_RS31070	COG0149	triose-phosphate isomerase activity
D1369_RS31075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1369_RS31085	COG0166	Belongs to the GPI family
D1369_RS31095	COG0363	glucosamine-6-phosphate deaminase activity
D1369_RS31110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1369_RS31125	COG0109	protoheme IX farnesyltransferase activity
D1369_RS31150	COG1131	(ABC) transporter
D1369_RS31155	COG2746	aminoglycoside 3-N-acetyltransferase activity
D1369_RS31170	COG0719	Fe-S assembly protein
D1369_RS31180	COG0396	ATPase activity
D1369_RS31185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1369_RS31190	COG0822	iron-sulfur transferase activity
D1369_RS31195	COG2151	metal-sulfur cluster biosynthetic enzyme
D1369_RS31210	COG2076	Multidrug Resistance protein
D1369_RS31215	COG3226	Transcriptional regulator
D1369_RS31230	COG2171	N-acyltransferase activity
D1369_RS31235	COG1595	DNA-templated transcription, initiation
D1369_RS31245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS31265	COG1295	ribonuclease BN
D1369_RS31265	COG1959	2 iron, 2 sulfur cluster binding
D1369_RS31305	COG1802	Transcriptional regulator
D1369_RS31320	COG1309	transcriptional regulator
D1369_RS31330	COG1063	alcohol dehydrogenase
D1369_RS31335	COG0395	ABC-type sugar transport system, permease component
D1369_RS31350	COG1349	DNA-binding transcription factor activity
D1369_RS31355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1369_RS31360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS31385	COG1802	Transcriptional regulator
D1369_RS31390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS31400	COG1175	transmembrane transport
D1369_RS31405	COG0395	ABC-type sugar transport system, permease component
D1369_RS31425	COG3507	Belongs to the glycosyl hydrolase 43 family
D1369_RS31430	COG4677	pectinesterase activity
D1369_RS31440	COG2755	lipolytic protein G-D-S-L family
D1369_RS31445	COG3866	Pectate lyase
D1369_RS31450	COG4677	pectinesterase activity
D1369_RS31455	COG4677	pectinesterase activity
D1369_RS31485	COG1595	DNA-templated transcription, initiation
D1369_RS31490	COG2252	PERMEase
D1369_RS31505	COG1414	Transcriptional regulator
D1369_RS31525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1369_RS31530	COG5285	phytanoyl-CoA dioxygenase
D1369_RS31535	COG1917	Cupin 2, conserved barrel domain protein
D1369_RS31540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1369_RS31545	COG0456	acetyltransferase
D1369_RS31550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1369_RS31560	COG0765	amino acid transport
D1369_RS31565	COG1126	abc transporter atp-binding protein
D1369_RS31580	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D1369_RS31615	COG1797	cobyrinic acid a,c-diamide synthase activity
D1369_RS31635	COG1492	cobalamin metabolic process
D1369_RS31640	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1369_RS31660	COG0235	Class ii aldolase
D1369_RS31685	COG0488	(ABC) transporter
D1369_RS31735	COG3387	PFAM Glycoside hydrolase 15-related
D1369_RS31750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1369_RS31770	COG1063	alcohol dehydrogenase
D1369_RS31780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1369_RS31800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1369_RS31805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1369_RS31825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1369_RS31835	COG0312	modulator of DNA gyrase
D1369_RS31840	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS31855	COG2186	Transcriptional regulator
D1369_RS31880	COG3830	Belongs to the UPF0237 family
D1369_RS31880	COG0560	Phosphoserine phosphatase
D1369_RS31890	COG1716	ATPase activity
D1369_RS31890	COG1131	(ABC) transporter
D1369_RS31890	COG0842	Transport permease protein
D1369_RS31900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1369_RS31905	COG4221	oxidoreductase activity
D1369_RS31915	COG2197	response regulator
D1369_RS31930	COG1119	ATPase activity
D1369_RS31950	COG1881	PFAM PEBP family protein
D1369_RS31960	COG2094	Belongs to the DNA glycosylase MPG family
D1369_RS31995	COG0647	UMP catabolic process
D1369_RS32000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1369_RS32005	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1369_RS32010	COG1120	ATPase activity
D1369_RS32030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1369_RS32035	COG0497	DNA recombination
D1369_RS32060	COG3387	PFAM Glycoside hydrolase 15-related
D1369_RS32065	COG0504	CTP synthase activity
D1369_RS32070	COG0494	nUDIX hydrolase
D1369_RS32080	COG0686	Belongs to the AlaDH PNT family
D1369_RS32095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D1369_RS32100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1369_RS32105	COG1187	pseudouridine synthase activity
D1369_RS32155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1369_RS32165	COG1160	GTP binding
D1369_RS32180	COG1652	LysM domain
D1369_RS32190	COG0411	ABC transporter
D1369_RS32215	COG0596	Alpha beta hydrolase
D1369_RS32235	COG0671	phosphoesterase, PA-phosphatase related
D1369_RS32250	COG0477	Major facilitator Superfamily
D1369_RS32255	COG1960	acyl-CoA dehydrogenase activity
D1369_RS32260	COG1799	cell septum assembly
D1369_RS32285	COG0330	HflC and HflK could
D1369_RS32345	COG0587	DNA-directed DNA polymerase activity
D1369_RS32395	COG1725	Transcriptional regulator
D1369_RS32420	COG0726	polysaccharide deacetylase
D1369_RS32430	COG0463	Glycosyl transferase, family 2
D1369_RS32450	COG2755	lipolytic protein G-D-S-L family
D1369_RS32475	COG1595	DNA-templated transcription, initiation
D1369_RS32510	COG2188	Transcriptional regulator
D1369_RS32515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1369_RS32525	COG1309	transcriptional regulator
D1369_RS32540	COG0243	molybdopterin cofactor binding
D1369_RS32545	COG2851	Citrate transporter
D1369_RS32585	COG0477	Major facilitator Superfamily
D1369_RS32605	COG1960	acyl-CoA dehydrogenase activity
D1369_RS32655	COG3876	Protein conserved in bacteria
D1369_RS32665	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS32695	COG2149	membrane
D1369_RS32705	COG2205	protein histidine kinase activity
D1369_RS32710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1369_RS32750	COG3265	gluconokinase activity
D1369_RS32755	COG2186	Transcriptional regulator
D1369_RS32760	COG3012	SEC-C Motif Domain Protein
D1369_RS32765	COG0308	aminopeptidase N
D1369_RS32810	COG0667	Aldo Keto reductase
D1369_RS32815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS32825	COG0598	Magnesium transport protein CorA
D1369_RS32830	COG0406	alpha-ribazole phosphatase activity
D1369_RS32845	COG0215	cysteine-tRNA ligase activity
D1369_RS32860	COG2186	Transcriptional regulator
D1369_RS32865	COG0235	Class ii aldolase
D1369_RS32865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1369_RS32870	COG0235	Class ii aldolase
D1369_RS32875	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D1369_RS32880	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D1369_RS32890	COG1129	ABC transporter
D1369_RS32900	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D1369_RS32910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1369_RS32915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1369_RS32920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1369_RS32925	COG1414	Transcriptional regulator
D1369_RS32930	COG0646	methionine synthase
D1369_RS32930	COG1410	methionine synthase
D1369_RS32935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1369_RS32940	COG4166	transmembrane transport
D1369_RS32945	COG4166	transmembrane transport
D1369_RS32950	COG2197	response regulator
D1369_RS32960	COG0517	IMP dehydrogenase activity
D1369_RS32960	COG1994	Peptidase M50
D1369_RS32985	COG1222	aaa ATPase
D1369_RS32990	COG4122	O-methyltransferase activity
D1369_RS33005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1369_RS33010	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1369_RS33015	COG1609	Transcriptional regulator
D1369_RS33025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1369_RS33030	COG0545	Peptidyl-prolyl cis-trans isomerase
D1369_RS33040	COG2378	regulation of single-species biofilm formation
D1369_RS33060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1369_RS33065	COG0805	protein transport
D1369_RS33135	COG0564	pseudouridine synthase activity
D1369_RS33175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1369_RS33180	COG0517	IMP dehydrogenase activity
D1369_RS33180	COG4175	Glycine betaine
D1369_RS33195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1369_RS33215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1369_RS33220	COG2186	Transcriptional regulator
D1369_RS33225	COG0174	glutamine synthetase
D1369_RS33230	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS33285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1369_RS33290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1369_RS33295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1369_RS33300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1369_RS33305	COG5002	protein histidine kinase activity
D1369_RS33310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1369_RS33315	COG0072	phenylalanine-tRNA ligase activity
D1369_RS33315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1369_RS33345	COG1649	PFAM Uncharacterised BCR, COG1649
D1369_RS33355	COG0697	spore germination
D1369_RS33405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1369_RS33410	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1369_RS33415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1369_RS33420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1369_RS33425	COG1438	arginine binding
D1369_RS33440	COG1017	nitric oxide dioxygenase activity
D1369_RS33440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1369_RS33450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1369_RS33450	COG1017	nitric oxide dioxygenase activity
D1369_RS33455	COG0745	RESPONSE REGULATOR receiver
D1369_RS33460	COG2205	protein histidine kinase activity
D1369_RS33475	COG0165	Argininosuccinate lyase
D1369_RS33490	COG0477	Major facilitator Superfamily
D1369_RS33495	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS33495	COG0204	Acyl-transferase
D1369_RS33530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1369_RS33535	COG2011	ABC-type metal ion transport system permease component
D1369_RS33540	COG1464	Belongs to the NlpA lipoprotein family
D1369_RS33555	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1369_RS33560	COG1648	precorrin-2 dehydrogenase activity
D1369_RS33560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1369_RS33620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1369_RS33665	COG1653	transport
D1369_RS33670	COG1175	transmembrane transport
D1369_RS33675	COG0395	ABC-type sugar transport system, permease component
D1369_RS33705	COG5002	protein histidine kinase activity
D1369_RS33705	COG2176	DNA-directed DNA polymerase activity
D1369_RS33720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1369_RS33725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1369_RS33745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1369_RS33750	COG1560	Kdo2-lipid A biosynthetic process
D1369_RS33755	COG0438	transferase activity, transferring glycosyl groups
D1369_RS33765	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1369_RS33770	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1369_RS33775	COG0217	transcriptional regulatory protein
D1369_RS33780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1369_RS33785	COG0632	four-way junction helicase activity
D1369_RS33790	COG2255	four-way junction helicase activity
D1369_RS33800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1369_RS33805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1369_RS33810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1369_RS33820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1369_RS33825	COG1196	nuclear chromosome segregation
D1369_RS33830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1369_RS33840	COG0124	histidyl-tRNA synthetase
D1369_RS33845	COG2197	response regulator
D1369_RS33850	COG4585	Histidine kinase
D1369_RS33860	COG1131	(ABC) transporter
D1369_RS33875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1369_RS33895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1369_RS33900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1369_RS33910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1369_RS33915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1369_RS33920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1369_RS33925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1369_RS33930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1369_RS33940	COG0006	proline dipeptidase activity
D1369_RS33945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1369_RS33950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1369_RS33960	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1369_RS33965	COG0540	Belongs to the ATCase OTCase family
D1369_RS33970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1369_RS33980	COG0505	Belongs to the CarA family
D1369_RS33985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1369_RS33990	COG0167	dihydroorotate dehydrogenase activity
D1369_RS33995	COG0284	orotidine-5'-phosphate decarboxylase activity
D1369_RS34005	COG0194	GDP metabolic process
D1369_RS34010	COG1758	RNA polymerase activity
D1369_RS34020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1369_RS34035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1369_RS34045	COG2409	Drug exporters of the RND superfamily
D1369_RS34050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1369_RS34055	COG2390	Transcriptional regulator
D1369_RS34085	COG0531	amino acid
D1369_RS34100	COG2188	Transcriptional regulator
D1369_RS34110	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1369_RS34120	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1369_RS34135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1369_RS34160	COG2223	nitrite transmembrane transporter activity
D1369_RS34165	COG1846	Transcriptional regulator
D1369_RS34165	COG1940	carbohydrate kinase activity
D1369_RS34180	COG3201	nicotinamide mononucleotide transporter
D1369_RS34185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1369_RS34185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1369_RS34190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1369_RS34195	COG0140	phosphoribosyl-ATP diphosphatase activity
D1369_RS34200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1369_RS34250	COG1960	acyl-CoA dehydrogenase activity
D1369_RS34280	COG1216	Glycosyl transferase, family 2
D1369_RS34295	COG2270	Major facilitator Superfamily
D1369_RS34305	COG2364	Membrane
D1369_RS34345	COG0438	transferase activity, transferring glycosyl groups
D1369_RS34350	COG2755	lipolytic protein G-D-S-L family
D1369_RS34355	COG1984	allophanate hydrolase subunit 2
D1369_RS34360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1369_RS34365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D1369_RS34370	COG4336	lyase activity
D1369_RS34375	COG2814	Major facilitator Superfamily
D1369_RS34425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1369_RS34430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1369_RS34435	COG3706	GGDEF domain
D1369_RS34440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1369_RS34460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1369_RS34465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1369_RS34480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1369_RS34515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1369_RS34535	COG1716	ATPase activity
D1369_RS34555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1369_RS34565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1369_RS34565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1369_RS34580	COG1175	transmembrane transport
D1369_RS34585	COG0395	ABC-type sugar transport system, permease component
D1369_RS34595	COG1609	Transcriptional regulator
D1369_RS34635	COG1595	DNA-templated transcription, initiation
D1369_RS34640	COG0657	acetylesterase activity
D1369_RS34725	COG0697	spore germination
D1369_RS34810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1369_RS34825	COG2318	DinB family
D1369_RS34835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1369_RS34845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1369_RS34875	COG2318	DinB family
D1369_RS34885	COG0583	DNA-binding transcription factor activity
D1369_RS34890	COG5006	permease, DMT superfamily
D1369_RS34900	COG1968	undecaprenyl-diphosphatase activity
D1369_RS34910	COG0183	Belongs to the thiolase family
D1369_RS34920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1369_RS34935	COG2814	Major facilitator Superfamily
D1369_RS34945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1369_RS34965	COG0110	maltose O-acetyltransferase activity
D1369_RS34990	COG0640	Transcriptional regulator
D1369_RS35000	COG0531	amino acid
D1369_RS35005	COG1832	CoA-binding protein
D1369_RS35010	COG2326	polyphosphate kinase activity
D1369_RS35025	COG1739	Uncharacterized protein family UPF0029
D1369_RS35030	COG0420	3'-5' exonuclease activity
D1369_RS35035	COG0419	ATPase involved in DNA repair
D1369_RS35040	COG1522	sequence-specific DNA binding
D1369_RS35065	COG0626	cystathionine gamma-synthase activity
D1369_RS35090	COG0596	Alpha beta hydrolase
D1369_RS35095	COG1595	DNA-templated transcription, initiation
D1369_RS35100	COG2188	Transcriptional regulator
D1369_RS35105	COG1940	carbohydrate kinase activity
D1369_RS35110	COG2197	response regulator
D1369_RS35115	COG4585	Histidine kinase
D1369_RS35135	COG3663	DNA glycosylase
D1369_RS35140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1369_RS35155	COG1063	alcohol dehydrogenase
D1369_RS35165	COG0402	S-adenosylhomocysteine deaminase activity
D1369_RS35180	COG2267	carboxylic ester hydrolase activity
D1369_RS35240	COG1136	(ABC) transporter
D1369_RS35240	COG0577	efflux transmembrane transporter activity
D1369_RS35245	COG1136	(ABC) transporter
D1369_RS35260	COG2226	methyltransferase
D1369_RS35265	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1369_RS35270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1369_RS35275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1369_RS35280	COG0156	8-amino-7-oxononanoate synthase activity
D1369_RS35315	COG0740	serine-type endopeptidase activity
D1369_RS35320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1369_RS35360	COG1309	transcriptional regulator
D1369_RS35365	COG0831	urea catabolic process
D1369_RS35370	COG0832	Belongs to the urease beta subunit family
D1369_RS35375	COG0804	urea catabolic process
D1369_RS35385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1369_RS35390	COG0829	nickel cation binding
D1369_RS35420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1369_RS35425	COG1834	amidinotransferase
D1369_RS35430	COG1522	sequence-specific DNA binding
D1369_RS35435	COG3279	Response regulator of the LytR AlgR family
D1369_RS35445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1369_RS35450	COG3275	phosphorelay sensor kinase activity
D1369_RS35460	COG2815	serine threonine protein kinase
D1369_RS35460	COG0515	serine threonine protein kinase
D1369_RS35475	COG0205	6-phosphofructokinase activity
D1369_RS35480	COG3442	glutamine amidotransferase
D1369_RS35490	COG0242	peptide deformylase activity
D1369_RS35500	COG1960	acyl-CoA dehydrogenase activity
D1369_RS35505	COG2124	cytochrome p450
D1369_RS35525	COG1793	dna ligase
D1369_RS35560	COG1960	acyl-CoA dehydrogenase activity
D1369_RS35565	COG1960	acyl-CoA dehydrogenase activity
D1369_RS35600	COG1051	belongs to the nudix hydrolase family
D1369_RS35625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1369_RS35635	COG2146	nitrite reductase [NAD(P)H] activity
D1369_RS35640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1369_RS35645	COG4638	Rieske (2fe-2S)
D1369_RS35655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D1369_RS35660	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS35665	COG0517	IMP dehydrogenase activity
D1369_RS35665	COG4175	Glycine betaine
D1369_RS35670	COG4176	ABC-type proline glycine betaine transport system permease component
D1369_RS35685	COG1414	Transcriptional regulator
D1369_RS35700	COG1609	Transcriptional regulator
D1369_RS35715	COG0395	ABC-type sugar transport system, permease component
D1369_RS35740	COG2182	Extracellular solute-binding protein
D1369_RS35770	COG0326	Molecular chaperone. Has ATPase activity
D1369_RS35785	COG1404	Belongs to the peptidase S8 family
D1369_RS35805	COG1024	Enoyl-CoA hydratase
D1369_RS35805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1369_RS35845	COG0375	protein maturation
D1369_RS35850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1369_RS35855	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D1369_RS35860	COG0298	carbon dioxide binding
D1369_RS35870	COG0309	Hydrogenase expression formation protein (HypE)
D1369_RS35880	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS35900	COG1940	carbohydrate kinase activity
D1369_RS35910	COG2115	Belongs to the xylose isomerase family
D1369_RS35920	COG1309	transcriptional regulator
D1369_RS35940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1369_RS35945	COG3239	Fatty acid desaturase
D1369_RS36015	COG2018	Roadblock/LC7 domain
D1369_RS36025	COG1946	Acyl-CoA thioesterase
D1369_RS36040	COG0254	rRNA binding
D1369_RS36050	COG1132	(ABC) transporter
D1369_RS36055	COG1132	(ABC) transporter
D1369_RS36070	COG1301	dicarboxylic acid transport
D1369_RS36080	COG1132	(ABC) transporter
D1369_RS36090	COG2072	flavoprotein involved in K transport
D1369_RS36100	COG1116	anion transmembrane transporter activity
D1369_RS36105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1369_RS36110	COG0432	Pfam Uncharacterised protein family UPF0047
D1369_RS36125	COG1129	ABC transporter
D1369_RS36130	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1369_RS36150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1369_RS36160	COG0640	Transcriptional regulator
D1369_RS36170	COG1404	Belongs to the peptidase S8 family
D1369_RS36180	COG0745	RESPONSE REGULATOR receiver
D1369_RS36185	COG2205	protein histidine kinase activity
D1369_RS36220	COG1609	Transcriptional regulator
D1369_RS36220	COG2207	Transcriptional regulator
D1369_RS36235	COG0714	Associated with various cellular activities
D1369_RS36245	COG2124	cytochrome p450
D1369_RS36255	COG0438	transferase activity, transferring glycosyl groups
D1369_RS36265	COG0789	Transcriptional regulator
D1369_RS36285	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D1369_RS36290	COG0366	Alpha amylase catalytic
D1369_RS36315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1369_RS36320	COG4948	Mandelate Racemase Muconate Lactonizing
D1369_RS36325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1369_RS36330	COG0395	ABC-type sugar transport system, permease component
D1369_RS36335	COG1175	transmembrane transport
D1369_RS36340	COG1653	transport
D1369_RS36405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1369_RS36420	COG1609	Transcriptional regulator
D1369_RS36430	COG1129	ABC transporter
D1369_RS36435	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1369_RS36445	COG2160	L-arabinose isomerase activity
D1369_RS36450	COG0235	Class ii aldolase
D1369_RS36470	COG1960	acyl-CoA dehydrogenase activity
D1369_RS36490	COG3509	depolymerase
D1369_RS36525	COG1309	transcriptional regulator
D1369_RS36560	COG0667	Aldo Keto reductase
D1369_RS36565	COG1597	lipid kinase activity
D1369_RS36580	COG0584	glycerophosphoryl diester phosphodiesterase
D1369_RS36615	COG0204	Acyl-transferase
D1369_RS36640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1369_RS36655	COG0515	serine threonine protein kinase
D1369_RS36675	COG3345	alpha-galactosidase
D1369_RS36685	COG1660	Displays ATPase and GTPase activities
D1369_RS36690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS36695	COG0747	negative chemotaxis
D1369_RS36700	COG0601	transmembrane transport
D1369_RS36705	COG0444	Belongs to the ABC transporter superfamily
D1369_RS36710	COG4608	Belongs to the ABC transporter superfamily
D1369_RS36720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1369_RS36730	COG0445	tRNA wobble uridine modification
D1369_RS36745	COG4585	Histidine kinase
D1369_RS36750	COG2197	response regulator
D1369_RS36785	COG2223	nitrite transmembrane transporter activity
D1369_RS36795	COG1414	Transcriptional regulator
D1369_RS36800	COG2610	gluconate transmembrane transporter activity
D1369_RS36805	COG4948	Mandelate Racemase Muconate Lactonizing
D1369_RS36810	COG1228	amidohydrolase
D1369_RS36830	COG1175	transmembrane transport
D1369_RS36835	COG0395	ABC-type sugar transport system, permease component
D1369_RS36870	COG0515	serine threonine protein kinase
D1369_RS36870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1369_RS36885	COG1653	transport
D1369_RS36895	COG0584	glycerophosphoryl diester phosphodiesterase
D1369_RS36905	COG2409	Drug exporters of the RND superfamily
D1369_RS36915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS36915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1369_RS36915	COG1703	isobutyryl-CoA mutase activity
D1369_RS36925	COG1660	Displays ATPase and GTPase activities
D1369_RS36930	COG1609	Transcriptional regulator
D1369_RS36945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1369_RS36950	COG4608	Belongs to the ABC transporter superfamily
D1369_RS36955	COG0444	Belongs to the ABC transporter superfamily
D1369_RS36965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1369_RS36975	COG2267	carboxylic ester hydrolase activity
D1369_RS36980	COG2186	Transcriptional regulator
D1369_RS36990	COG2814	Major facilitator Superfamily
D1369_RS37000	COG1609	Transcriptional regulator
D1369_RS37010	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D1369_RS37035	COG2197	response regulator
D1369_RS37075	COG1175	transmembrane transport
D1369_RS37080	COG0395	ABC-type sugar transport system, permease component
D1369_RS37100	COG0384	phenazine biosynthesis protein PhzF
D1369_RS37105	COG3387	PFAM Glycoside hydrolase 15-related
D1369_RS37110	COG1349	DNA-binding transcription factor activity
D1369_RS37115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1369_RS37120	COG0191	fructose-bisphosphate aldolase activity
D1369_RS37130	COG2813	Specifically methylates the guanine in position
D1369_RS37140	COG1940	carbohydrate kinase activity
D1369_RS37190	COG0577	efflux transmembrane transporter activity
D1369_RS37190	COG1136	(ABC) transporter
D1369_RS37195	COG0577	efflux transmembrane transporter activity
D1369_RS37220	COG1349	DNA-binding transcription factor activity
D1369_RS37240	COG3217	Mosc domain protein beta barrel domain protein
D1369_RS37240	COG0633	Ferredoxin
D1369_RS37255	COG0463	Glycosyl transferase, family 2
D1369_RS37260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1369_RS37285	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS37300	COG3693	PFAM glycoside hydrolase, family 10
D1369_RS37320	COG3693	PFAM glycoside hydrolase, family 10
D1369_RS37335	COG0640	Transcriptional regulator
D1369_RS37340	COG1316	TRANSCRIPTIONal
D1369_RS37345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1369_RS37375	COG2226	methyltransferase
D1369_RS37390	COG0667	Aldo Keto reductase
D1369_RS37405	COG1960	acyl-CoA dehydrogenase activity
D1369_RS37450	COG0640	Transcriptional regulator
D1369_RS37460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1369_RS37465	COG1993	acr, cog1993
D1369_RS37470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1369_RS37475	COG1968	undecaprenyl-diphosphatase activity
D1369_RS37480	COG2186	Transcriptional regulator
D1369_RS37485	COG1113	amino acid transport
D1369_RS37500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1369_RS37510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1369_RS37515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1369_RS37525	COG2066	Belongs to the glutaminase family
D1369_RS37540	COG1686	Belongs to the peptidase S11 family
D1369_RS37545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1369_RS37555	COG3795	YCII-related domain
D1369_RS37565	COG4941	Belongs to the sigma-70 factor family
D1369_RS37570	COG2226	methyltransferase
D1369_RS37580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1369_RS37585	COG3458	cephalosporin-C deacetylase activity
D1369_RS37600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1369_RS37620	COG2890	protein-(glutamine-N5) methyltransferase activity
D1369_RS37670	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1369_RS37670	COG1902	pentaerythritol trinitrate reductase activity
D1369_RS37700	COG1461	Dihydroxyacetone kinase
D1369_RS37705	COG2376	Dihydroxyacetone kinase
D1369_RS37720	COG0672	)-iron permease
D1369_RS37740	COG3387	PFAM Glycoside hydrolase 15-related
D1369_RS37755	COG1960	acyl-CoA dehydrogenase activity
D1369_RS37780	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
D1369_RS37785	COG0028	Belongs to the TPP enzyme family
D1369_RS37805	COG2409	Drug exporters of the RND superfamily
D1369_RS37810	COG1309	transcriptional regulator
D1369_RS37820	COG0300	oxidoreductase activity
D1369_RS37875	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS37905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1369_RS37920	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS37990	COG1053	succinate dehydrogenase
D1369_RS38000	COG0702	epimerase
D1369_RS38030	COG0516	GMP reductase activity
D1369_RS38030	COG0517	IMP dehydrogenase activity
D1369_RS38050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1369_RS38080	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D1369_RS38085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1369_RS38090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1369_RS38090	COG1042	CoA-binding domain protein
D1369_RS38090	COG0045	succinate-CoA ligase (ADP-forming) activity
D1369_RS38120	COG1063	alcohol dehydrogenase
D1369_RS38140	COG0574	Belongs to the PEP-utilizing enzyme family
D1369_RS38140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1369_RS38170	COG3321	synthase
D1369_RS38170	COG0604	alcohol dehydrogenase
D1369_RS38190	COG1309	transcriptional regulator
D1369_RS38205	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS38220	COG0515	serine threonine protein kinase
D1369_RS38240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1369_RS38245	COG2070	2-Nitropropane dioxygenase
D1369_RS38255	COG2366	antibiotic biosynthetic process
D1369_RS38260	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS38270	COG0596	Alpha beta hydrolase
D1369_RS38285	COG1024	Enoyl-CoA hydratase
D1369_RS38380	COG2814	Major facilitator Superfamily
D1369_RS38400	COG0456	acetyltransferase
D1369_RS38440	COG0702	epimerase
D1369_RS38470	COG0431	NADPH-dependent FMN reductase
D1369_RS38480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS38485	COG2267	carboxylic ester hydrolase activity
D1369_RS38500	COG4941	Belongs to the sigma-70 factor family
D1369_RS38505	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS38530	COG1082	Xylose isomerase domain protein TIM barrel
D1369_RS38530	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1369_RS38535	COG0667	Aldo Keto reductase
D1369_RS38545	COG0412	Dienelactone hydrolase
D1369_RS38550	COG0346	lactoylglutathione lyase activity
D1369_RS38555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1369_RS38570	COG0583	DNA-binding transcription factor activity
D1369_RS38575	COG0667	Aldo Keto reductase
D1369_RS38595	COG1131	(ABC) transporter
D1369_RS38595	COG1716	ATPase activity
D1369_RS38595	COG0842	Transport permease protein
D1369_RS38625	COG1191	sigma factor activity
D1369_RS38630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1369_RS38635	COG1396	sequence-specific DNA binding
D1369_RS38640	COG0740	serine-type endopeptidase activity
D1369_RS38645	COG0740	serine-type endopeptidase activity
D1369_RS38650	COG0596	Alpha beta hydrolase
D1369_RS38680	COG0328	RNA-DNA hybrid ribonuclease activity
D1369_RS38690	COG2304	oxidoreductase activity
D1369_RS38705	COG0477	Major facilitator Superfamily
D1369_RS38720	COG0667	Aldo Keto reductase
D1369_RS38730	COG3647	Membrane
D1369_RS38745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS38755	COG0515	serine threonine protein kinase
D1369_RS38780	COG2340	Cysteine-rich secretory protein family
D1369_RS38790	COG1940	carbohydrate kinase activity
D1369_RS38790	COG1846	Transcriptional regulator
D1369_RS38795	COG3345	alpha-galactosidase
D1369_RS38810	COG1672	PFAM Archaeal ATPase
D1369_RS38810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1369_RS38820	COG3852	Histidine kinase
D1369_RS38825	COG0492	ferredoxin-NADP+ reductase activity
D1369_RS38845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1369_RS38885	COG5002	protein histidine kinase activity
D1369_RS38920	COG0477	Major facilitator Superfamily
D1369_RS38975	COG1252	NADH dehydrogenase
D1369_RS39000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1369_RS39005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1369_RS39010	COG3281	Trehalose synthase
D1369_RS39020	COG0366	Alpha amylase catalytic
D1369_RS39050	COG1191	sigma factor activity
D1369_RS39065	COG0842	Transport permease protein
D1369_RS39075	COG0181	hydroxymethylbilane synthase activity
D1369_RS39090	COG2814	Major facilitator Superfamily
D1369_RS39095	COG0640	Transcriptional regulator
D1369_RS39110	COG1793	dna ligase
D1369_RS39115	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS39125	COG2197	response regulator
D1369_RS39180	COG0656	L-ascorbic acid biosynthetic process
D1369_RS39185	COG1609	Transcriptional regulator
D1369_RS39195	COG0395	ABC-type sugar transport system, permease component
D1369_RS39200	COG1175	transmembrane transport
D1369_RS39235	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS39245	COG2045	Belongs to the ComB family
D1369_RS39255	COG0513	Belongs to the DEAD box helicase family
D1369_RS39265	COG0009	L-threonylcarbamoyladenylate synthase
D1369_RS39270	COG0789	Transcriptional regulator
D1369_RS39295	COG0596	Alpha beta hydrolase
D1369_RS39300	COG3903	Transcriptional regulator
D1369_RS39300	COG3629	intracellular signal transduction
D1369_RS39320	COG2197	response regulator
D1369_RS39325	COG4585	Histidine kinase
D1369_RS39330	COG1136	(ABC) transporter
D1369_RS39330	COG0577	efflux transmembrane transporter activity
D1369_RS39340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1369_RS39375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS39375	COG3321	synthase
D1369_RS39380	COG0318	PFAM AMP-dependent synthetase and ligase
D1369_RS39385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1369_RS39395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1369_RS39400	COG2353	YceI-like domain
D1369_RS39405	COG2124	cytochrome p450
D1369_RS39515	COG0667	Aldo Keto reductase
D1369_RS39540	COG4251	negative regulation of phosphorylation
D1369_RS39545	COG0784	Response regulator, receiver
D1369_RS39595	COG1597	lipid kinase activity
D1369_RS39620	COG2308	Evidence 4 Homologs of previously reported genes of
D1369_RS39620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1369_RS39625	COG0367	asparagine synthase
D1369_RS39635	COG0514	ATP-dependent DNA helicase (RecQ)
D1369_RS39645	COG0784	Response regulator, receiver
D1369_RS39645	COG2205	protein histidine kinase activity
D1369_RS39645	COG5002	protein histidine kinase activity
D1369_RS39650	COG1366	Belongs to the anti-sigma-factor antagonist family
D1369_RS39695	COG2409	Drug exporters of the RND superfamily
D1369_RS39700	COG4585	Histidine kinase
D1369_RS39705	COG2197	response regulator
D1369_RS39780	COG0142	geranyltranstransferase activity
D1369_RS39800	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D1369_RS39805	COG0596	Alpha beta hydrolase
D1369_RS39810	COG2770	Histidine kinase
D1369_RS39810	COG2208	phosphoserine phosphatase activity
D1369_RS39820	COG3848	Pyruvate phosphate dikinase
D1369_RS39820	COG0574	Belongs to the PEP-utilizing enzyme family
D1369_RS39845	COG2172	sigma factor antagonist activity
D1369_RS39850	COG1366	Belongs to the anti-sigma-factor antagonist family
D1369_RS39855	COG1366	Belongs to the anti-sigma-factor antagonist family
D1369_RS39910	COG0604	alcohol dehydrogenase
D1369_RS39950	COG0477	Major facilitator Superfamily
D1369_RS39980	COG1764	response to oxidative stress
D1369_RS40005	COG0488	(ABC) transporter
D1369_RS40010	COG0488	(ABC) transporter
D1369_RS40050	COG0477	Major facilitator Superfamily
D1369_RS40065	COG2423	ornithine cyclodeaminase activity
D1369_RS40075	COG0346	lactoylglutathione lyase activity
D1369_RS40105	COG1278	Cold shock
D1369_RS40115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1369_RS40145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1369_RS40155	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1369_RS40160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D1369_RS40180	COG2072	flavoprotein involved in K transport
D1369_RS40190	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS40200	COG2223	nitrite transmembrane transporter activity
D1369_RS40205	COG2186	Transcriptional regulator
D1369_RS40210	COG4214	carbohydrate transport
D1369_RS40215	COG1129	ABC transporter
D1369_RS40225	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1369_RS40230	COG4948	Mandelate Racemase Muconate Lactonizing
D1369_RS40235	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS40245	COG3254	rhamnose metabolic process
D1369_RS40255	COG0247	lactate metabolic process
D1369_RS40260	COG1139	Iron-sulfur cluster binding protein
D1369_RS40265	COG1556	Lactate utilization protein
D1369_RS40290	COG1960	acyl-CoA dehydrogenase activity
D1369_RS40295	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1369_RS40315	COG0583	DNA-binding transcription factor activity
D1369_RS40320	COG4552	Acetyltransferase involved in intracellular survival and related
D1369_RS40340	COG0583	DNA-binding transcription factor activity
D1369_RS40350	COG1733	regulation of RNA biosynthetic process
D1369_RS40360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1369_RS40365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D1369_RS40400	COG1113	amino acid transport
D1369_RS40410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1369_RS40415	COG0546	phosphoglycolate phosphatase activity
D1369_RS40420	COG0738	Major facilitator superfamily
D1369_RS40435	COG0604	alcohol dehydrogenase
D1369_RS40440	COG1408	metallophosphoesterase
D1369_RS40475	COG3345	alpha-galactosidase
D1369_RS40520	COG3507	Belongs to the glycosyl hydrolase 43 family
D1369_RS40530	COG1335	isochorismatase
D1369_RS40560	COG2318	DinB family
D1369_RS40605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1369_RS40620	COG0640	Transcriptional regulator
D1369_RS40650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS40670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS40675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS40680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS40700	COG2318	DinB family
D1369_RS40730	COG2272	Belongs to the type-B carboxylesterase lipase family
D1369_RS40750	COG0142	geranyltranstransferase activity
D1369_RS40805	COG0823	Involved in the tonB-independent uptake of proteins
D1369_RS40805	COG1506	peptidase
D1369_RS40830	COG0069	glutamate synthase activity
D1369_RS40835	COG0028	Belongs to the TPP enzyme family
D1369_RS40885	COG3631	Ketosteroid isomerase-related protein
D1369_RS40890	COG0702	epimerase
D1369_RS40945	COG0583	DNA-binding transcription factor activity
D1369_RS40950	COG1131	(ABC) transporter
D1369_RS40970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1369_RS41000	COG1028	Short-chain dehydrogenase reductase Sdr
D1369_RS41005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1369_RS41010	COG0156	8-amino-7-oxononanoate synthase activity
D1369_RS41015	COG1454	alcohol dehydrogenase
D1369_RS41040	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
D1369_RS41045	COG0148	phosphopyruvate hydratase activity
D1369_RS41055	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS41065	COG1309	transcriptional regulator
D1369_RS41175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1369_RS41235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1369_RS41255	COG1366	Belongs to the anti-sigma-factor antagonist family
D1369_RS41265	COG1191	sigma factor activity
D1369_RS41295	COG2610	gluconate transmembrane transporter activity
D1369_RS41425	COG2755	lipolytic protein G-D-S-L family
D1369_RS41475	COG2814	Major facilitator Superfamily
D1369_RS41485	COG0583	DNA-binding transcription factor activity
D1369_RS41490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1369_RS41515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1369_RS41525	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D1369_RS41540	COG3321	synthase
D1369_RS41540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1369_RS41540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1369_RS41540	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D1369_RS41545	COG1509	lysine 2,3-aminomutase activity
D1369_RS41550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1369_RS41570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1369_RS41620	COG1278	Cold shock
D1369_RS41660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1369_RS41675	COG0251	oxidation-reduction process
D1369_RS41680	COG0583	DNA-binding transcription factor activity
D1369_RS41725	COG0477	Major facilitator Superfamily
D1369_RS41735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1369_RS41765	COG0076	glutamate decarboxylase activity
D1369_RS41775	COG1846	Transcriptional regulator
D1369_RS41780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1369_RS41785	COG1012	belongs to the aldehyde dehydrogenase family
D1369_RS41815	COG4689	acetoacetate decarboxylase
D1369_RS41880	COG2197	response regulator
D1369_RS41895	COG5520	Belongs to the glycosyl hydrolase 30 family
D1369_RS41915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1369_RS41935	COG1309	transcriptional regulator
D1369_RS41945	COG2814	Major facilitator Superfamily
D1369_RS41950	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1369_RS42035	COG2801	Transposase and inactivated derivatives
D1369_RS42085	COG1121	(ABC) transporter
D1369_RS42350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1369_RS42490	COG0653	protein targeting
D1369_RS42635	COG0420	3'-5' exonuclease activity
D1369_RS42640	COG0419	ATPase involved in DNA repair