locus-tag	class	description
NI25_RS00205	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NI25_RS00225	COG0477	Major facilitator Superfamily
NI25_RS00225	COG2814	Major facilitator Superfamily
NI25_RS00240	COG2159	amidohydrolase
NI25_RS00265	COG0367	asparagine synthase
NI25_RS00300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NI25_RS00315	COG0640	Transcriptional regulator
NI25_RS00335	COG2815	serine threonine protein kinase
NI25_RS00335	COG0515	serine threonine protein kinase
NI25_RS00345	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NI25_RS00350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NI25_RS00380	COG2936	dipeptidyl-peptidase activity
NI25_RS00410	COG2843	Capsule synthesis protein
NI25_RS00420	COG0765	amino acid transport
NI25_RS00425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NI25_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS00460	COG0726	polysaccharide deacetylase
NI25_RS00470	COG3507	Belongs to the glycosyl hydrolase 43 family
NI25_RS00480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NI25_RS00485	COG1309	transcriptional regulator
NI25_RS00510	COG1846	Transcriptional regulator
NI25_RS00535	COG0583	DNA-binding transcription factor activity
NI25_RS00560	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS00575	COG1846	Transcriptional regulator
NI25_RS00580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NI25_RS00590	COG1278	Cold shock
NI25_RS00595	COG1132	(ABC) transporter
NI25_RS00615	COG0753	catalase activity
NI25_RS00625	COG2249	NAD(P)H dehydrogenase (quinone) activity
NI25_RS00640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NI25_RS00645	COG0438	transferase activity, transferring glycosyl groups
NI25_RS00660	COG0367	asparagine synthase
NI25_RS00695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NI25_RS00700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NI25_RS00710	COG4310	Domain of unknown function (DUF2172)
NI25_RS00720	COG1215	transferase activity, transferring glycosyl groups
NI25_RS00730	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NI25_RS00735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NI25_RS00765	COG2226	methyltransferase
NI25_RS00770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NI25_RS00790	COG1595	DNA-templated transcription, initiation
NI25_RS00810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NI25_RS00825	COG0527	aspartate kinase activity
NI25_RS00825	COG0460	homoserine dehydrogenase
NI25_RS00850	COG0667	Aldo Keto reductase
NI25_RS00875	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NI25_RS00890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NI25_RS00900	COG1984	allophanate hydrolase subunit 2
NI25_RS00930	COG0477	Major facilitator Superfamily
NI25_RS00935	COG1879	ABC-type sugar transport system periplasmic component
NI25_RS00950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NI25_RS00960	COG1175	transmembrane transport
NI25_RS00965	COG0395	ABC-type sugar transport system, permease component
NI25_RS00970	COG1609	Transcriptional regulator
NI25_RS00980	COG1472	Belongs to the glycosyl hydrolase 3 family
NI25_RS01015	COG0346	lactoylglutathione lyase activity
NI25_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
NI25_RS01035	COG0483	inositol monophosphate 1-phosphatase activity
NI25_RS01070	COG2382	esterase
NI25_RS01075	COG1132	(ABC) transporter
NI25_RS01085	COG1132	(ABC) transporter
NI25_RS01090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NI25_RS01095	COG1120	ATPase activity
NI25_RS01100	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI25_RS01105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI25_RS01110	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NI25_RS01125	COG2936	dipeptidyl-peptidase activity
NI25_RS01135	COG0513	Belongs to the DEAD box helicase family
NI25_RS01145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NI25_RS01150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NI25_RS01160	COG0666	response to abiotic stimulus
NI25_RS01185	COG1278	Cold shock
NI25_RS01195	COG0673	inositol 2-dehydrogenase activity
NI25_RS01200	COG2188	Transcriptional regulator
NI25_RS01205	COG2182	Extracellular solute-binding protein
NI25_RS01210	COG1175	transmembrane transport
NI25_RS01215	COG0395	ABC-type sugar transport system, permease component
NI25_RS01220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NI25_RS01225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NI25_RS01250	COG0395	ABC-type sugar transport system, permease component
NI25_RS01255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NI25_RS01270	COG0739	heme binding
NI25_RS01290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NI25_RS01300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NI25_RS01305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI25_RS01310	COG2340	Cysteine-rich secretory protein family
NI25_RS01315	COG2205	protein histidine kinase activity
NI25_RS01320	COG0745	RESPONSE REGULATOR receiver
NI25_RS01355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NI25_RS01385	COG0142	geranyltranstransferase activity
NI25_RS01395	COG0142	geranyltranstransferase activity
NI25_RS01405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NI25_RS01410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NI25_RS01415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NI25_RS01420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NI25_RS01435	COG3340	Belongs to the peptidase S51 family
NI25_RS01440	COG2084	Dehydrogenase
NI25_RS01445	COG1082	Xylose isomerase domain protein TIM barrel
NI25_RS01450	COG0149	triose-phosphate isomerase activity
NI25_RS01455	COG0698	ribose 5-phosphate isomerase
NI25_RS01460	COG2376	Dihydroxyacetone kinase
NI25_RS01470	COG2186	Transcriptional regulator
NI25_RS01475	COG2124	cytochrome p450
NI25_RS01495	COG2018	Roadblock/LC7 domain
NI25_RS01525	COG0655	NAD(P)H dehydrogenase (quinone) activity
NI25_RS01530	COG0783	Belongs to the Dps family
NI25_RS01550	COG1191	sigma factor activity
NI25_RS01555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NI25_RS01600	COG2235	arginine
NI25_RS01620	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NI25_RS01635	COG1937	Protein conserved in bacteria
NI25_RS01640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NI25_RS01675	COG1233	COG1233 Phytoene dehydrogenase and related
NI25_RS01695	COG1595	DNA-templated transcription, initiation
NI25_RS01710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NI25_RS01715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NI25_RS01735	COG0488	(ABC) transporter
NI25_RS01775	COG1120	ATPase activity
NI25_RS01780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI25_RS01810	COG3397	chitin binding
NI25_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS01835	COG2264	protein methyltransferase activity
NI25_RS01900	COG1175	transmembrane transport
NI25_RS01905	COG0395	ABC-type sugar transport system, permease component
NI25_RS01910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NI25_RS01935	COG0277	FAD linked oxidase domain protein
NI25_RS01975	COG3290	protein histidine kinase activity
NI25_RS01990	COG0477	Major facilitator Superfamily
NI25_RS02020	COG1295	ribonuclease BN
NI25_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS02035	COG2080	2 iron, 2 sulfur cluster binding
NI25_RS02040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NI25_RS02045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NI25_RS02055	COG0656	L-ascorbic acid biosynthetic process
NI25_RS02085	COG0693	protein deglycase activity
NI25_RS02150	COG1132	(ABC) transporter
NI25_RS02200	COG0410	ABC transporter
NI25_RS02205	COG2508	Transcriptional regulator
NI25_RS02220	COG0673	inositol 2-dehydrogenase activity
NI25_RS02295	COG1309	transcriptional regulator
NI25_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS02355	COG1132	(ABC) transporter
NI25_RS02380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NI25_RS02420	COG0517	IMP dehydrogenase activity
NI25_RS02450	COG2274	protein secretion by the type I secretion system
NI25_RS02455	COG0248	Ppx GppA phosphatase
NI25_RS02470	COG2890	protein-(glutamine-N5) methyltransferase activity
NI25_RS02500	COG3250	beta-galactosidase activity
NI25_RS02515	COG0667	Aldo Keto reductase
NI25_RS02530	COG2124	cytochrome p450
NI25_RS02545	COG0435	Glutathione S-transferase
NI25_RS02575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NI25_RS02605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NI25_RS02605	COG1796	DNA polymerase
NI25_RS02630	COG1940	carbohydrate kinase activity
NI25_RS02650	COG2706	6-phosphogluconolactonase activity
NI25_RS02660	COG1309	transcriptional regulator
NI25_RS02670	COG1357	PFAM Pentapeptide repeats (8 copies)
NI25_RS02675	COG1595	DNA-templated transcription, initiation
NI25_RS02690	COG1609	Transcriptional regulator
NI25_RS02710	COG1172	Belongs to the binding-protein-dependent transport system permease family
NI25_RS02715	COG1129	ABC transporter
NI25_RS02720	COG4952	isomerase
NI25_RS02725	COG3347	Dehydrogenase
NI25_RS02725	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS02730	COG1070	Carbohydrate kinase
NI25_RS02735	COG0247	lactate metabolic process
NI25_RS02740	COG1139	Iron-sulfur cluster binding protein
NI25_RS02745	COG1556	Lactate utilization protein
NI25_RS02750	COG0577	efflux transmembrane transporter activity
NI25_RS02750	COG1136	(ABC) transporter
NI25_RS02775	COG1725	Transcriptional regulator
NI25_RS02780	COG1131	(ABC) transporter
NI25_RS02800	COG3540	Alkaline phosphatase
NI25_RS02840	COG0668	transmembrane transport
NI25_RS02855	COG2409	Drug exporters of the RND superfamily
NI25_RS02860	COG1846	Transcriptional regulator
NI25_RS02865	COG0702	epimerase
NI25_RS02890	COG0604	alcohol dehydrogenase
NI25_RS02910	COG1070	Carbohydrate kinase
NI25_RS02925	COG1175	transmembrane transport
NI25_RS02930	COG0395	ABC-type sugar transport system, permease component
NI25_RS02935	COG1609	Transcriptional regulator
NI25_RS02955	COG0800	Aldolase
NI25_RS02970	COG0657	acetylesterase activity
NI25_RS03010	COG4106	trans-aconitate 2-methyltransferase activity
NI25_RS03025	COG0242	peptide deformylase activity
NI25_RS03035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NI25_RS03040	COG1609	Transcriptional regulator
NI25_RS03055	COG0583	DNA-binding transcription factor activity
NI25_RS03075	COG1053	succinate dehydrogenase
NI25_RS03075	COG3976	FMN-binding domain protein
NI25_RS03080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NI25_RS03090	COG0517	IMP dehydrogenase activity
NI25_RS03100	COG3903	Transcriptional regulator
NI25_RS03100	COG3629	intracellular signal transduction
NI25_RS03105	COG0596	Alpha beta hydrolase
NI25_RS03130	COG2409	Drug exporters of the RND superfamily
NI25_RS03155	COG3572	ergothioneine biosynthetic process
NI25_RS03160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NI25_RS03165	COG0121	glutamine amidotransferase
NI25_RS03170	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NI25_RS03175	COG2182	Extracellular solute-binding protein
NI25_RS03180	COG3360	Dodecin
NI25_RS03190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS03215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NI25_RS03220	COG1053	succinate dehydrogenase
NI25_RS03230	COG0583	DNA-binding transcription factor activity
NI25_RS03240	COG0583	DNA-binding transcription factor activity
NI25_RS03285	COG0726	polysaccharide deacetylase
NI25_RS03295	COG0531	amino acid
NI25_RS03330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NI25_RS03355	COG0395	ABC-type sugar transport system, permease component
NI25_RS03360	COG1175	transmembrane transport
NI25_RS03370	COG1609	Transcriptional regulator
NI25_RS03405	COG3537	Alpha-1,2-mannosidase
NI25_RS03415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NI25_RS03420	COG0297	glycogen (starch) synthase activity
NI25_RS03440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NI25_RS03450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NI25_RS03490	COG0516	GMP reductase activity
NI25_RS03490	COG0517	IMP dehydrogenase activity
NI25_RS03535	COG1063	alcohol dehydrogenase
NI25_RS03540	COG0589	response to stress
NI25_RS03565	COG0745	RESPONSE REGULATOR receiver
NI25_RS03570	COG2205	protein histidine kinase activity
NI25_RS03590	COG0702	epimerase
NI25_RS03600	COG3046	protein related to deoxyribodipyrimidine photolyase
NI25_RS03605	COG0142	geranyltranstransferase activity
NI25_RS03625	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NI25_RS03675	COG0517	IMP dehydrogenase activity
NI25_RS03725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NI25_RS03740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NI25_RS03740	COG0574	Belongs to the PEP-utilizing enzyme family
NI25_RS03750	COG0517	IMP dehydrogenase activity
NI25_RS03750	COG0516	GMP reductase activity
NI25_RS03755	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS03755	COG1454	alcohol dehydrogenase
NI25_RS03765	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NI25_RS03775	COG0549	Belongs to the carbamate kinase family
NI25_RS03865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI25_RS03870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI25_RS03900	COG4585	Histidine kinase
NI25_RS03905	COG2201	protein-glutamate methylesterase activity
NI25_RS03915	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS03935	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS03960	COG1132	(ABC) transporter
NI25_RS03965	COG1132	(ABC) transporter
NI25_RS03965	COG2375	cellular response to nickel ion
NI25_RS03970	COG4106	trans-aconitate 2-methyltransferase activity
NI25_RS03975	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NI25_RS03980	COG2124	cytochrome p450
NI25_RS03985	COG4106	trans-aconitate 2-methyltransferase activity
NI25_RS03995	COG3433	isochorismatase activity
NI25_RS03995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI25_RS03995	COG2226	methyltransferase
NI25_RS04000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI25_RS04000	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NI25_RS04005	COG1021	2,3-dihydroxybenzoate-AMP ligase
NI25_RS04010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NI25_RS04015	COG4171	peptide transport system, permease
NI25_RS04025	COG0747	negative chemotaxis
NI25_RS04030	COG3959	Transketolase, thiamine diphosphate binding domain
NI25_RS04040	COG0803	Belongs to the bacterial solute-binding protein 9 family
NI25_RS04050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NI25_RS04055	COG1121	(ABC) transporter
NI25_RS04070	COG0402	S-adenosylhomocysteine deaminase activity
NI25_RS04075	COG2233	PERMEase
NI25_RS04140	COG1653	transport
NI25_RS04145	COG1175	transmembrane transport
NI25_RS04150	COG3833	ABC-type maltose transport systems, permease component
NI25_RS04155	COG0366	Alpha amylase catalytic
NI25_RS04165	COG1132	(ABC) transporter
NI25_RS04185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NI25_RS04195	COG0531	amino acid
NI25_RS04200	COG0668	transmembrane transport
NI25_RS04205	COG2838	Isocitrate dehydrogenase
NI25_RS04220	COG2124	cytochrome p450
NI25_RS04235	COG1404	Belongs to the peptidase S8 family
NI25_RS04245	COG2197	response regulator
NI25_RS04260	COG0385	Bile acid
NI25_RS04265	COG0673	inositol 2-dehydrogenase activity
NI25_RS04270	COG3548	integral membrane protein
NI25_RS04275	COG1609	Transcriptional regulator
NI25_RS04285	COG0673	inositol 2-dehydrogenase activity
NI25_RS04290	COG2764	glyoxalase bleomycin resistance protein dioxygenase
NI25_RS04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NI25_RS04325	COG3718	enzyme involved in inositol metabolism
NI25_RS04330	COG3962	Belongs to the TPP enzyme family
NI25_RS04335	COG2188	Transcriptional regulator
NI25_RS04355	COG0367	asparagine synthase
NI25_RS04390	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS04395	COG0183	Belongs to the thiolase family
NI25_RS04400	COG2267	carboxylic ester hydrolase activity
NI25_RS04425	COG0174	glutamine synthetase
NI25_RS04440	COG1320	monovalent cation:proton antiporter activity
NI25_RS04455	COG0651	ATP synthesis coupled electron transport
NI25_RS04460	COG1006	Multisubunit Na H antiporter MnhC subunit
NI25_RS04465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI25_RS04465	COG2111	Na H antiporter
NI25_RS04495	COG0583	DNA-binding transcription factor activity
NI25_RS04500	COG0156	8-amino-7-oxononanoate synthase activity
NI25_RS04505	COG1063	alcohol dehydrogenase
NI25_RS04550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI25_RS04565	COG0179	Fumarylacetoacetate (FAA) hydrolase
NI25_RS04595	COG2755	lipolytic protein G-D-S-L family
NI25_RS04605	COG2365	Tyrosine phosphatase family
NI25_RS04625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NI25_RS04630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NI25_RS04645	COG1657	PFAM Prenyltransferase squalene oxidase
NI25_RS04655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NI25_RS04670	COG1562	ergosterol biosynthetic process
NI25_RS04675	COG1134	teichoic acid transport
NI25_RS04715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NI25_RS04725	COG1024	Enoyl-CoA hydratase
NI25_RS04745	COG2183	response to ionizing radiation
NI25_RS04750	COG0488	(ABC) transporter
NI25_RS04760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NI25_RS04775	COG1113	amino acid transport
NI25_RS04785	COG1024	Enoyl-CoA hydratase
NI25_RS04785	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI25_RS04790	COG0183	Belongs to the thiolase family
NI25_RS04795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NI25_RS04800	COG3268	Saccharopine dehydrogenase
NI25_RS04815	COG1515	deoxyribonuclease V activity
NI25_RS04845	COG0488	(ABC) transporter
NI25_RS04850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NI25_RS04855	COG1834	amidinotransferase
NI25_RS04905	COG1793	dna ligase
NI25_RS04915	COG1470	cell adhesion involved in biofilm formation
NI25_RS04935	COG0183	Belongs to the thiolase family
NI25_RS04940	COG3485	protocatechuate 3,4-dioxygenase
NI25_RS04945	COG3485	protocatechuate 3,4-dioxygenase
NI25_RS04950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NI25_RS04955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI25_RS04985	COG3511	phospholipase C
NI25_RS04990	COG0477	Major facilitator Superfamily
NI25_RS05000	COG2197	response regulator
NI25_RS05005	COG1132	(ABC) transporter
NI25_RS05010	COG1132	(ABC) transporter
NI25_RS05020	COG0515	serine threonine protein kinase
NI25_RS05060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NI25_RS05070	COG1486	melibiose metabolic process
NI25_RS05080	COG4585	Histidine kinase
NI25_RS05085	COG2197	response regulator
NI25_RS05110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NI25_RS05125	COG0166	Belongs to the GPI family
NI25_RS05130	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NI25_RS05145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NI25_RS05165	COG0297	glycogen (starch) synthase activity
NI25_RS05180	COG1183	phosphatidylcholine synthase activity
NI25_RS05190	COG1309	transcriptional regulator
NI25_RS05205	COG0747	negative chemotaxis
NI25_RS05215	COG0443	Heat shock 70 kDa protein
NI25_RS05270	COG2815	serine threonine protein kinase
NI25_RS05270	COG0515	serine threonine protein kinase
NI25_RS05285	COG0210	DNA helicase
NI25_RS05310	COG0300	oxidoreductase activity
NI25_RS05335	COG3340	Belongs to the peptidase S51 family
NI25_RS05365	COG1733	regulation of RNA biosynthetic process
NI25_RS05380	COG4632	Exopolysaccharide biosynthesis protein
NI25_RS05380	COG5434	Belongs to the glycosyl hydrolase 28 family
NI25_RS05395	COG2723	6-phospho-beta-galactosidase activity
NI25_RS05400	COG0395	ABC-type sugar transport system, permease component
NI25_RS05405	COG1175	transmembrane transport
NI25_RS05410	COG2182	Extracellular solute-binding protein
NI25_RS05415	COG1940	carbohydrate kinase activity
NI25_RS05455	COG0129	dihydroxy-acid dehydratase activity
NI25_RS05465	COG1472	Belongs to the glycosyl hydrolase 3 family
NI25_RS05475	COG1175	transmembrane transport
NI25_RS05485	COG1609	Transcriptional regulator
NI25_RS05490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NI25_RS05505	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS05515	COG0045	succinate-CoA ligase (ADP-forming) activity
NI25_RS05525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NI25_RS05535	COG2223	nitrite transmembrane transporter activity
NI25_RS05590	COG0673	inositol 2-dehydrogenase activity
NI25_RS05600	COG1172	Belongs to the binding-protein-dependent transport system permease family
NI25_RS05605	COG1129	ABC transporter
NI25_RS05620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI25_RS05630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NI25_RS05635	COG3383	formate dehydrogenase (NAD+) activity
NI25_RS05640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NI25_RS05650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NI25_RS05655	COG1846	Transcriptional regulator
NI25_RS05680	COG0477	Major facilitator Superfamily
NI25_RS05690	COG0656	L-ascorbic acid biosynthetic process
NI25_RS05695	COG4221	oxidoreductase activity
NI25_RS05700	COG2226	methyltransferase
NI25_RS05705	COG5297	Belongs to the glycosyl hydrolase family 6
NI25_RS05710	COG4733	cellulase activity
NI25_RS05710	COG5297	Belongs to the glycosyl hydrolase family 6
NI25_RS05725	COG3401	FG-GAP repeat protein
NI25_RS05735	COG2154	pterin-4-alpha-carbinolamine dehydratase
NI25_RS05765	COG1140	nitrate reductase beta subunit
NI25_RS05795	COG0531	amino acid
NI25_RS05850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NI25_RS05860	COG0693	protein deglycase activity
NI25_RS05875	COG0488	(ABC) transporter
NI25_RS05880	COG1597	lipid kinase activity
NI25_RS05945	COG3285	dna ligase
NI25_RS05945	COG1793	dna ligase
NI25_RS05960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS05990	COG1619	proteins homologs of microcin C7 resistance protein MccF
NI25_RS06000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NI25_RS06005	COG2362	D-Aminopeptidase
NI25_RS06045	COG0596	Alpha beta hydrolase
NI25_RS06065	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI25_RS06075	COG0604	alcohol dehydrogenase
NI25_RS06080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS06080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS06085	COG2301	Belongs to the HpcH HpaI aldolase family
NI25_RS06095	COG1960	acyl-CoA dehydrogenase activity
NI25_RS06100	COG0688	phosphatidylethanolamine metabolic process
NI25_RS06110	COG1929	Belongs to the glycerate kinase type-1 family
NI25_RS06120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NI25_RS06130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NI25_RS06145	COG0640	Transcriptional regulator
NI25_RS06170	COG0444	Belongs to the ABC transporter superfamily
NI25_RS06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI25_RS06180	COG0601	transmembrane transport
NI25_RS06195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NI25_RS06205	COG0483	inositol monophosphate 1-phosphatase activity
NI25_RS06220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NI25_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS06235	COG1891	lyase activity
NI25_RS06245	COG4585	Histidine kinase
NI25_RS06255	COG2197	response regulator
NI25_RS06275	COG1953	Uracil, thiamine, allantoin
NI25_RS06280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS06285	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NI25_RS06300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NI25_RS06320	COG0542	response to heat
NI25_RS06325	COG0405	Gamma-glutamyltransferase
NI25_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS06350	COG0154	amidase activity
NI25_RS06370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI25_RS06405	COG3387	PFAM Glycoside hydrolase 15-related
NI25_RS06485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI25_RS06495	COG0242	peptide deformylase activity
NI25_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS06820	COG1937	Protein conserved in bacteria
NI25_RS06830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NI25_RS06830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NI25_RS06835	COG0785	Cytochrome C biogenesis protein
NI25_RS06840	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NI25_RS06845	COG0730	response to heat
NI25_RS06930	COG0714	Associated with various cellular activities
NI25_RS07030	COG3547	Transposase (IS116 IS110 IS902 family)
NI25_RS07055	COG0159	tryptophan synthase activity
NI25_RS07135	COG1007	ATP synthesis coupled electron transport
NI25_RS07145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI25_RS07150	COG0713	ATP synthesis coupled electron transport
NI25_RS07160	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NI25_RS07165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS07170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS07180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NI25_RS07220	COG1937	Protein conserved in bacteria
NI25_RS07305	COG0785	Cytochrome C biogenesis protein
NI25_RS07310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NI25_RS07325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NI25_RS07340	COG0745	RESPONSE REGULATOR receiver
NI25_RS07350	COG2409	Drug exporters of the RND superfamily
NI25_RS07375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NI25_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS07390	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NI25_RS07425	COG0789	Transcriptional regulator
NI25_RS07435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NI25_RS07460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NI25_RS07460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NI25_RS07530	COG0640	Transcriptional regulator
NI25_RS07535	COG2072	flavoprotein involved in K transport
NI25_RS07540	COG0798	PFAM Bile acid sodium symporter
NI25_RS07550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI25_RS07555	COG0492	ferredoxin-NADP+ reductase activity
NI25_RS07560	COG3118	belongs to the thioredoxin family
NI25_RS07565	COG0464	growth
NI25_RS07605	COG1733	regulation of RNA biosynthetic process
NI25_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS07665	COG0402	S-adenosylhomocysteine deaminase activity
NI25_RS07685	COG2197	response regulator
NI25_RS07710	COG3851	Histidine kinase
NI25_RS07725	COG2197	response regulator
NI25_RS07745	COG3293	Transposase
NI25_RS07790	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS07810	COG1595	DNA-templated transcription, initiation
NI25_RS07815	COG0445	tRNA wobble uridine modification
NI25_RS07820	COG1819	glycosyl
NI25_RS07825	COG0789	Transcriptional regulator
NI25_RS07830	COG1959	2 iron, 2 sulfur cluster binding
NI25_RS07835	COG1063	alcohol dehydrogenase
NI25_RS07850	COG0346	lactoylglutathione lyase activity
NI25_RS07855	COG0667	Aldo Keto reductase
NI25_RS07860	COG1733	regulation of RNA biosynthetic process
NI25_RS07895	COG0142	geranyltranstransferase activity
NI25_RS07925	COG0477	Major facilitator Superfamily
NI25_RS07930	COG1032	radical SAM domain protein
NI25_RS07935	COG0437	4 iron, 4 sulfur cluster binding
NI25_RS07950	COG3383	formate dehydrogenase (NAD+) activity
NI25_RS07950	COG0243	molybdopterin cofactor binding
NI25_RS07955	COG3383	formate dehydrogenase (NAD+) activity
NI25_RS07955	COG0243	molybdopterin cofactor binding
NI25_RS07960	COG0709	Synthesizes selenophosphate from selenide and ATP
NI25_RS07985	COG3246	L-lysine catabolic process to acetate
NI25_RS07990	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI25_RS08010	COG1132	(ABC) transporter
NI25_RS08015	COG1802	Transcriptional regulator
NI25_RS08020	COG3938	Belongs to the proline racemase family
NI25_RS08025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NI25_RS08030	COG0446	pyridine nucleotide-disulphide oxidoreductase
NI25_RS08040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI25_RS08050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NI25_RS08060	COG1940	carbohydrate kinase activity
NI25_RS08065	COG1129	ABC transporter
NI25_RS08080	COG2188	Transcriptional regulator
NI25_RS08085	COG0673	inositol 2-dehydrogenase activity
NI25_RS08095	COG2197	response regulator
NI25_RS08120	COG1846	Transcriptional regulator
NI25_RS08125	COG2197	response regulator
NI25_RS08130	COG1819	glycosyl
NI25_RS08160	COG3321	synthase
NI25_RS08160	COG0604	alcohol dehydrogenase
NI25_RS08165	COG3321	synthase
NI25_RS08165	COG0604	alcohol dehydrogenase
NI25_RS08170	COG3321	synthase
NI25_RS08170	COG0604	alcohol dehydrogenase
NI25_RS08180	COG0667	Aldo Keto reductase
NI25_RS08205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI25_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS08220	COG4266	Belongs to the allantoicase family
NI25_RS08225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NI25_RS08230	COG1414	Transcriptional regulator
NI25_RS08245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NI25_RS08330	COG0406	alpha-ribazole phosphatase activity
NI25_RS08345	COG2233	PERMEase
NI25_RS08355	COG2233	PERMEase
NI25_RS08365	COG2351	hydroxyisourate hydrolase activity
NI25_RS08385	COG3622	Belongs to the hyi family
NI25_RS08390	COG2084	Dehydrogenase
NI25_RS08395	COG0753	catalase activity
NI25_RS08410	COG3960	tartronate-semialdehyde synthase activity
NI25_RS08420	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS08425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NI25_RS08430	COG2197	response regulator
NI25_RS08515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NI25_RS08515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NI25_RS08520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NI25_RS08525	COG0438	transferase activity, transferring glycosyl groups
NI25_RS08535	COG0859	PFAM glycosyl transferase family 9
NI25_RS08540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NI25_RS08550	COG2192	nodulation
NI25_RS08555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NI25_RS08560	COG0726	polysaccharide deacetylase
NI25_RS08580	COG2252	PERMEase
NI25_RS08585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NI25_RS08600	COG3835	regulator
NI25_RS08630	COG3851	Histidine kinase
NI25_RS08635	COG2197	response regulator
NI25_RS08645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NI25_RS08650	COG1802	Transcriptional regulator
NI25_RS08670	COG0028	Belongs to the TPP enzyme family
NI25_RS08690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NI25_RS08700	COG1162	GTPase activity
NI25_RS08715	COG0277	FAD linked oxidase domain protein
NI25_RS08755	COG2197	response regulator
NI25_RS08770	COG2040	homocysteine
NI25_RS08785	COG0714	Associated with various cellular activities
NI25_RS08800	COG2027	D-alanyl-D-alanine carboxypeptidase
NI25_RS08855	COG3142	Participates in the control of copper homeostasis
NI25_RS08865	COG1846	Transcriptional regulator
NI25_RS08865	COG1940	carbohydrate kinase activity
NI25_RS08900	COG1960	acyl-CoA dehydrogenase activity
NI25_RS08920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NI25_RS08930	COG0175	sulfate reduction
NI25_RS08935	COG0529	Catalyzes the synthesis of activated sulfate
NI25_RS08955	COG1116	anion transmembrane transporter activity
NI25_RS08960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NI25_RS08985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NI25_RS09045	COG3173	Aminoglycoside phosphotransferase
NI25_RS09055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NI25_RS09075	COG1309	transcriptional regulator
NI25_RS09110	COG1174	glycine betaine transport
NI25_RS09115	COG1174	glycine betaine transport
NI25_RS09125	COG0745	RESPONSE REGULATOR receiver
NI25_RS09130	COG2205	protein histidine kinase activity
NI25_RS09140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NI25_RS09145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NI25_RS09185	COG0723	plastoquinol--plastocyanin reductase activity
NI25_RS09185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI25_RS09205	COG4152	abc transporter atp-binding protein
NI25_RS09215	COG3220	belongs to the UPF0276 family
NI25_RS09230	COG3253	May function as heme-dependent peroxidase
NI25_RS09235	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NI25_RS09245	COG0446	pyridine nucleotide-disulphide oxidoreductase
NI25_RS09285	COG1472	Belongs to the glycosyl hydrolase 3 family
NI25_RS09290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NI25_RS09305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NI25_RS09310	COG0183	Belongs to the thiolase family
NI25_RS09315	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI25_RS09315	COG1024	Enoyl-CoA hydratase
NI25_RS09320	COG1215	transferase activity, transferring glycosyl groups
NI25_RS09320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NI25_RS09325	COG1216	Glycosyl transferase, family 2
NI25_RS09330	COG1215	transferase activity, transferring glycosyl groups
NI25_RS09330	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NI25_RS09335	COG0438	transferase activity, transferring glycosyl groups
NI25_RS09345	COG1316	TRANSCRIPTIONal
NI25_RS09360	COG0531	amino acid
NI25_RS09365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NI25_RS09370	COG3979	chitinase
NI25_RS09375	COG4214	carbohydrate transport
NI25_RS09385	COG4213	ABC transporter substrate-binding protein
NI25_RS09390	COG1940	carbohydrate kinase activity
NI25_RS09395	COG0395	ABC-type sugar transport system, permease component
NI25_RS09400	COG1175	transmembrane transport
NI25_RS09405	COG1653	transport
NI25_RS09420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NI25_RS09425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NI25_RS09435	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS09445	COG1309	transcriptional regulator
NI25_RS09460	COG0583	DNA-binding transcription factor activity
NI25_RS09495	COG0785	Cytochrome C biogenesis protein
NI25_RS09500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NI25_RS09500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NI25_RS09570	COG1024	Enoyl-CoA hydratase
NI25_RS09580	COG0531	amino acid
NI25_RS09585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NI25_RS09590	COG2235	arginine
NI25_RS09595	COG0475	glutathione-regulated potassium exporter activity
NI25_RS09600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NI25_RS09630	COG1799	cell septum assembly
NI25_RS09635	COG0277	FAD linked oxidase domain protein
NI25_RS09635	COG0247	lactate metabolic process
NI25_RS09650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NI25_RS09660	COG0310	cobalt ion transport
NI25_RS09665	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NI25_RS09675	COG1122	ATPase activity
NI25_RS09680	COG0477	Major facilitator Superfamily
NI25_RS09715	COG2814	Major facilitator Superfamily
NI25_RS09730	COG1309	transcriptional regulator
NI25_RS09735	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS09755	COG0456	acetyltransferase
NI25_RS09760	COG3693	PFAM glycoside hydrolase, family 10
NI25_RS09790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NI25_RS09795	COG0531	amino acid
NI25_RS09820	COG0500	methyltransferase
NI25_RS09830	COG1088	dTDP-glucose 4,6-dehydratase activity
NI25_RS09840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI25_RS09845	COG0156	8-amino-7-oxononanoate synthase activity
NI25_RS09850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI25_RS09855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI25_RS09860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI25_RS09870	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NI25_RS09900	COG1960	acyl-CoA dehydrogenase activity
NI25_RS09910	COG3629	intracellular signal transduction
NI25_RS09915	COG0569	domain protein
NI25_RS09945	COG4591	ABC-type transport system involved in lipoprotein release permease component
NI25_RS09945	COG1136	(ABC) transporter
NI25_RS09955	COG0756	dUTP diphosphatase activity
NI25_RS09980	COG2205	protein histidine kinase activity
NI25_RS09985	COG0745	RESPONSE REGULATOR receiver
NI25_RS10000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NI25_RS10035	COG0384	phenazine biosynthesis protein PhzF
NI25_RS10040	COG1435	thymidine kinase activity
NI25_RS10060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NI25_RS10065	COG1802	Transcriptional regulator
NI25_RS10080	COG0612	Peptidase, M16
NI25_RS10085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NI25_RS10105	COG0372	Belongs to the citrate synthase family
NI25_RS10120	COG3290	protein histidine kinase activity
NI25_RS10125	COG4565	transcriptional regulatory protein
NI25_RS10130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NI25_RS10140	COG0187	DNA topoisomerase II activity
NI25_RS10155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NI25_RS10160	COG2186	Transcriptional regulator
NI25_RS10175	COG3328	transposase activity
NI25_RS10205	COG4974	Belongs to the 'phage' integrase family
NI25_RS10230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NI25_RS10250	COG0588	phosphoglycerate mutase activity
NI25_RS10265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NI25_RS10270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NI25_RS10275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NI25_RS10310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NI25_RS10320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NI25_RS10325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NI25_RS10335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NI25_RS10355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NI25_RS10360	COG4733	cellulase activity
NI25_RS10360	COG5297	Belongs to the glycosyl hydrolase family 6
NI25_RS10365	COG2197	response regulator
NI25_RS10370	COG3851	Histidine kinase
NI25_RS10395	COG2205	protein histidine kinase activity
NI25_RS10400	COG0745	RESPONSE REGULATOR receiver
NI25_RS10405	COG1126	abc transporter atp-binding protein
NI25_RS10410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NI25_RS10415	COG0765	amino acid transport
NI25_RS10420	COG0765	amino acid transport
NI25_RS10435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NI25_RS10445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NI25_RS10455	COG0628	permease
NI25_RS10480	COG1917	Cupin 2, conserved barrel domain protein
NI25_RS10480	COG2207	Transcriptional regulator
NI25_RS10485	COG1201	RNA secondary structure unwinding
NI25_RS10490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NI25_RS10510	COG0783	Belongs to the Dps family
NI25_RS10515	COG1396	sequence-specific DNA binding
NI25_RS10520	COG1058	Belongs to the CinA family
NI25_RS10520	COG1546	Belongs to the CinA family
NI25_RS10530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NI25_RS10540	COG1674	ftsk spoiiie
NI25_RS10550	COG4999	Histidine kinase
NI25_RS10550	COG3850	Histidine kinase
NI25_RS10550	COG3437	response regulator, receiver
NI25_RS10550	COG2205	protein histidine kinase activity
NI25_RS10555	COG2208	phosphoserine phosphatase activity
NI25_RS10555	COG2770	Histidine kinase
NI25_RS10585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NI25_RS10590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NI25_RS10595	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NI25_RS10615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NI25_RS10620	COG0612	Peptidase, M16
NI25_RS10625	COG1185	polyribonucleotide nucleotidyltransferase activity
NI25_RS10630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NI25_RS10650	COG1674	ftsk spoiiie
NI25_RS10670	COG1404	Belongs to the peptidase S8 family
NI25_RS10720	COG1404	Belongs to the peptidase S8 family
NI25_RS10745	COG3266	domain, Protein
NI25_RS10765	COG0455	bacterial-type flagellum organization
NI25_RS10770	COG4166	transmembrane transport
NI25_RS10775	COG0601	transmembrane transport
NI25_RS10780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI25_RS10790	COG4608	Belongs to the ABC transporter superfamily
NI25_RS10805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NI25_RS10810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NI25_RS10820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NI25_RS10835	COG0779	Required for maturation of 30S ribosomal subunits
NI25_RS10855	COG0442	prolyl-tRNA aminoacylation
NI25_RS10870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NI25_RS10875	COG0750	zinc metalloprotease
NI25_RS10880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NI25_RS10910	COG0395	ABC-type sugar transport system, permease component
NI25_RS10915	COG4209	transmembrane transport
NI25_RS10930	COG2197	response regulator
NI25_RS10945	COG0438	transferase activity, transferring glycosyl groups
NI25_RS10950	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS10955	COG2508	Transcriptional regulator
NI25_RS10990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI25_RS10995	COG1177	transmembrane transport
NI25_RS11000	COG1176	ABC-type spermidine putrescine transport system, permease component I
NI25_RS11005	COG3842	ATPase activity
NI25_RS11035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI25_RS11040	COG0584	glycerophosphoryl diester phosphodiesterase
NI25_RS11050	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS11060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NI25_RS11090	COG3842	ATPase activity
NI25_RS11095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NI25_RS11105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NI25_RS11110	COG0575	Belongs to the CDS family
NI25_RS11115	COG0233	cytoplasmic translational termination
NI25_RS11120	COG0528	UMP kinase activity
NI25_RS11125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NI25_RS11130	COG0052	Belongs to the universal ribosomal protein uS2 family
NI25_RS11135	COG4942	peptidase
NI25_RS11145	COG1191	sigma factor activity
NI25_RS11160	COG0792	nuclease activity
NI25_RS11180	COG0681	Belongs to the peptidase S26 family
NI25_RS11195	COG0335	large ribosomal subunit rRNA binding
NI25_RS11200	COG0336	Belongs to the RNA methyltransferase TrmD family
NI25_RS11205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NI25_RS11210	COG1837	Belongs to the UPF0109 family
NI25_RS11215	COG0228	four-way junction DNA binding
NI25_RS11240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NI25_RS11275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NI25_RS11285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NI25_RS11290	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS11295	COG0596	Alpha beta hydrolase
NI25_RS11310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI25_RS11315	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS11320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI25_RS11325	COG0477	Major facilitator Superfamily
NI25_RS11340	COG1254	Belongs to the acylphosphatase family
NI25_RS11345	COG2340	Cysteine-rich secretory protein family
NI25_RS11390	COG1733	regulation of RNA biosynthetic process
NI25_RS11395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NI25_RS11400	COG0571	ribonuclease III activity
NI25_RS11405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NI25_RS11420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NI25_RS11425	COG0742	ribosomal rna small subunit methyltransferase
NI25_RS11440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NI25_RS11445	COG0351	phosphomethylpyrimidine kinase
NI25_RS11460	COG1181	Belongs to the D-alanine--D-alanine ligase family
NI25_RS11465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NI25_RS11475	COG1920	GTP binding
NI25_RS11485	COG0776	regulation of translation
NI25_RS11495	COG0066	3-isopropylmalate dehydratase activity
NI25_RS11500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NI25_RS11505	COG1414	Transcriptional regulator
NI25_RS11550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NI25_RS11555	COG0179	Fumarylacetoacetate (FAA) hydrolase
NI25_RS11565	COG5002	protein histidine kinase activity
NI25_RS11570	COG2018	Roadblock/LC7 domain
NI25_RS11590	COG2018	Roadblock/LC7 domain
NI25_RS11610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI25_RS11615	COG5492	domain, Protein
NI25_RS11620	COG2353	YceI-like domain
NI25_RS11625	COG1335	isochorismatase
NI25_RS11645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NI25_RS11655	COG2957	Belongs to the agmatine deiminase family
NI25_RS11660	COG0804	urea catabolic process
NI25_RS11665	COG0832	Belongs to the urease beta subunit family
NI25_RS11665	COG0831	urea catabolic process
NI25_RS11675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NI25_RS11680	COG0473	3-isopropylmalate dehydrogenase activity
NI25_RS11690	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS11695	COG0506	proline dehydrogenase activity
NI25_RS11700	COG2508	Transcriptional regulator
NI25_RS11710	COG0477	Major facilitator Superfamily
NI25_RS11715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NI25_RS11720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NI25_RS11725	COG0440	acetolactate synthase activity
NI25_RS11735	COG5001	Diguanylate cyclase
NI25_RS11745	COG0667	Aldo Keto reductase
NI25_RS11750	COG2133	pyrroloquinoline quinone binding
NI25_RS11760	COG2197	response regulator
NI25_RS11775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NI25_RS11780	COG2409	Drug exporters of the RND superfamily
NI25_RS11785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NI25_RS11795	COG0154	amidase activity
NI25_RS11800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NI25_RS11825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NI25_RS11835	COG4221	oxidoreductase activity
NI25_RS11840	COG1611	Belongs to the LOG family
NI25_RS11855	COG0482	sulfurtransferase activity
NI25_RS11880	COG1309	transcriptional regulator
NI25_RS11890	COG0789	Transcriptional regulator
NI25_RS11900	COG2860	membrane
NI25_RS11905	COG4608	Belongs to the ABC transporter superfamily
NI25_RS11910	COG0444	Belongs to the ABC transporter superfamily
NI25_RS11925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI25_RS11945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NI25_RS11950	COG0509	glycine decarboxylation via glycine cleavage system
NI25_RS11955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NI25_RS11960	COG1760	l-serine dehydratase
NI25_RS11965	COG0477	Major facilitator Superfamily
NI25_RS11980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NI25_RS12010	COG1376	ErfK ybiS ycfS ynhG family protein
NI25_RS12025	COG2197	response regulator
NI25_RS12030	COG4585	Histidine kinase
NI25_RS12040	COG1131	(ABC) transporter
NI25_RS12045	COG1132	(ABC) transporter
NI25_RS12050	COG1132	(ABC) transporter
NI25_RS12055	COG1132	(ABC) transporter
NI25_RS12060	COG1132	(ABC) transporter
NI25_RS12080	COG0058	SHG alpha-glucan phosphorylase activity
NI25_RS12085	COG0366	Alpha amylase catalytic
NI25_RS12095	COG3281	Trehalose synthase
NI25_RS12100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NI25_RS12110	COG0492	ferredoxin-NADP+ reductase activity
NI25_RS12110	COG3118	belongs to the thioredoxin family
NI25_RS12120	COG1301	dicarboxylic acid transport
NI25_RS12125	COG3290	protein histidine kinase activity
NI25_RS12130	COG4565	transcriptional regulatory protein
NI25_RS12150	COG0582	viral genome integration into host DNA
NI25_RS12180	COG1653	transport
NI25_RS12190	COG0395	ABC-type sugar transport system, permease component
NI25_RS12200	COG0205	6-phosphofructokinase activity
NI25_RS12205	COG0857	belongs to the CobB CobQ family
NI25_RS12205	COG0280	phosphate acetyltransferase
NI25_RS12210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NI25_RS12245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS12245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS12295	COG0745	RESPONSE REGULATOR receiver
NI25_RS12315	COG0183	Belongs to the thiolase family
NI25_RS12335	COG1131	(ABC) transporter
NI25_RS12370	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NI25_RS12385	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI25_RS12420	COG4585	Histidine kinase
NI25_RS12425	COG2197	response regulator
NI25_RS12440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NI25_RS12445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NI25_RS12450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NI25_RS12455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NI25_RS12460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NI25_RS12465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NI25_RS12470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NI25_RS12485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NI25_RS12490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NI25_RS12495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI25_RS12505	COG2890	protein-(glutamine-N5) methyltransferase activity
NI25_RS12510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NI25_RS12515	COG0254	rRNA binding
NI25_RS12520	COG1316	TRANSCRIPTIONal
NI25_RS12535	COG0083	homoserine kinase activity
NI25_RS12540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NI25_RS12545	COG0460	homoserine dehydrogenase
NI25_RS12550	COG0019	diaminopimelate decarboxylase activity
NI25_RS12555	COG0018	arginyl-trna synthetase
NI25_RS12555	COG0018	arginyl-trna synthetase
NI25_RS12560	COG0745	RESPONSE REGULATOR receiver
NI25_RS12595	COG0515	serine threonine protein kinase
NI25_RS12630	COG1683	Conserved Protein
NI25_RS12650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI25_RS12655	COG2329	Antibiotic biosynthesis monooxygenase
NI25_RS12660	COG0662	Cupin 2, conserved barrel domain protein
NI25_RS12665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NI25_RS12670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NI25_RS12675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI25_RS12680	COG2867	negative regulation of translational initiation
NI25_RS12695	COG3467	pyridoxamine 5'-phosphate
NI25_RS12710	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NI25_RS12715	COG1793	dna ligase
NI25_RS12715	COG3285	dna ligase
NI25_RS12735	COG2205	protein histidine kinase activity
NI25_RS12775	COG0791	NLP P60 protein
NI25_RS12775	COG3883	PFAM NLP P60 protein
NI25_RS12820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NI25_RS12830	COG0745	RESPONSE REGULATOR receiver
NI25_RS12835	COG2205	protein histidine kinase activity
NI25_RS12840	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI25_RS12840	COG0567	Dehydrogenase, E1 component
NI25_RS12860	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NI25_RS12930	COG0542	response to heat
NI25_RS12940	COG0604	alcohol dehydrogenase
NI25_RS12945	COG0281	malic enzyme
NI25_RS12960	COG1126	abc transporter atp-binding protein
NI25_RS12965	COG4106	trans-aconitate 2-methyltransferase activity
NI25_RS12995	COG0142	geranyltranstransferase activity
NI25_RS13000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NI25_RS13040	COG1597	lipid kinase activity
NI25_RS13060	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS13065	COG0363	glucosamine-6-phosphate deaminase activity
NI25_RS13070	COG1472	Belongs to the glycosyl hydrolase 3 family
NI25_RS13075	COG0395	ABC-type sugar transport system, permease component
NI25_RS13080	COG1175	transmembrane transport
NI25_RS13085	COG2182	Extracellular solute-binding protein
NI25_RS13090	COG2188	Transcriptional regulator
NI25_RS13125	COG2124	cytochrome p450
NI25_RS13135	COG0242	peptide deformylase activity
NI25_RS13155	COG5662	AntiSigma factor
NI25_RS13160	COG1595	DNA-templated transcription, initiation
NI25_RS13170	COG2135	peptidase activity
NI25_RS13180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NI25_RS13190	COG2076	Multidrug Resistance protein
NI25_RS13200	COG0483	inositol monophosphate 1-phosphatase activity
NI25_RS13210	COG0753	catalase activity
NI25_RS13235	COG1615	UPF0182 protein
NI25_RS13245	COG3480	Lon protease (S16) C-terminal proteolytic domain
NI25_RS13295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NI25_RS13325	COG2816	NAD+ diphosphatase activity
NI25_RS13335	COG0210	DNA helicase
NI25_RS13340	COG0210	DNA helicase
NI25_RS13360	COG0596	Alpha beta hydrolase
NI25_RS13425	COG0513	Belongs to the DEAD box helicase family
NI25_RS13435	COG1432	Conserved Protein
NI25_RS13445	COG2095	MarC family integral membrane protein
NI25_RS13450	COG0613	PHP domain protein
NI25_RS13460	COG2814	Major facilitator Superfamily
NI25_RS13470	COG0598	Magnesium transport protein CorA
NI25_RS13505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NI25_RS13510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NI25_RS13520	COG1595	DNA-templated transcription, initiation
NI25_RS13530	COG1024	Enoyl-CoA hydratase
NI25_RS13535	COG0519	Catalyzes the synthesis of GMP from XMP
NI25_RS13545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NI25_RS13555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NI25_RS13600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NI25_RS13620	COG4608	Belongs to the ABC transporter superfamily
NI25_RS13625	COG0444	Belongs to the ABC transporter superfamily
NI25_RS13630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI25_RS13635	COG0601	transmembrane transport
NI25_RS13645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI25_RS13650	COG0747	negative chemotaxis
NI25_RS13660	COG0444	Belongs to the ABC transporter superfamily
NI25_RS13665	COG4608	Belongs to the ABC transporter superfamily
NI25_RS13670	COG4608	Belongs to the ABC transporter superfamily
NI25_RS13675	COG0444	Belongs to the ABC transporter superfamily
NI25_RS13680	COG0601	transmembrane transport
NI25_RS13685	COG0747	negative chemotaxis
NI25_RS13690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI25_RS13695	COG1217	gtp-binding protein TYPA
NI25_RS13715	COG1053	succinate dehydrogenase
NI25_RS13720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NI25_RS13770	COG2318	DinB family
NI25_RS13780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NI25_RS13810	COG0012	GTP binding
NI25_RS13825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NI25_RS13835	COG1570	exodeoxyribonuclease VII activity
NI25_RS13840	COG1722	exodeoxyribonuclease VII activity
NI25_RS13850	COG0778	Nitroreductase
NI25_RS13875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NI25_RS13875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NI25_RS13885	COG0114	fumarate hydratase activity
NI25_RS13900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NI25_RS13920	COG1136	(ABC) transporter
NI25_RS13935	COG0450	alkyl hydroperoxide reductase
NI25_RS13940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI25_RS13950	COG0741	lytic transglycosylase activity
NI25_RS13955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NI25_RS14025	COG2894	cell division
NI25_RS14065	COG2610	gluconate transmembrane transporter activity
NI25_RS14070	COG0251	oxidation-reduction process
NI25_RS14075	COG1414	Transcriptional regulator
NI25_RS14090	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NI25_RS14095	COG0436	Aminotransferase
NI25_RS14105	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NI25_RS14125	COG1331	Highly conserved protein containing a thioredoxin domain
NI25_RS14130	COG0590	tRNA wobble adenosine to inosine editing
NI25_RS14140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NI25_RS14150	COG2255	four-way junction helicase activity
NI25_RS14160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NI25_RS14170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NI25_RS14185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NI25_RS14215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NI25_RS14250	COG0667	Aldo Keto reductase
NI25_RS14265	COG1140	nitrate reductase beta subunit
NI25_RS14275	COG1090	epimerase
NI25_RS14280	COG1064	alcohol dehydrogenase
NI25_RS14290	COG1136	(ABC) transporter
NI25_RS14305	COG1309	transcriptional regulator
NI25_RS14330	COG2986	histidine ammonia-lyase
NI25_RS14340	COG1024	Enoyl-CoA hydratase
NI25_RS14350	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NI25_RS14360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI25_RS14375	COG0424	maF-like protein
NI25_RS14385	COG4770	biotin carboxylase activity
NI25_RS14410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NI25_RS14425	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS14430	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS14435	COG0515	serine threonine protein kinase
NI25_RS14515	COG1595	DNA-templated transcription, initiation
NI25_RS14520	COG0745	RESPONSE REGULATOR receiver
NI25_RS14525	COG2205	protein histidine kinase activity
NI25_RS14550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI25_RS14560	COG0583	DNA-binding transcription factor activity
NI25_RS14565	COG2814	Major facilitator Superfamily
NI25_RS14600	COG1079	Belongs to the binding-protein-dependent transport system permease family
NI25_RS14605	COG4603	Belongs to the binding-protein-dependent transport system permease family
NI25_RS14610	COG3845	ABC transporter
NI25_RS14615	COG1744	ABC transporter substrate-binding protein PnrA-like
NI25_RS14620	COG1744	ABC transporter substrate-binding protein PnrA-like
NI25_RS14625	COG1473	amidohydrolase
NI25_RS14625	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NI25_RS14635	COG2089	acid synthase
NI25_RS14650	COG1216	Glycosyl transferase, family 2
NI25_RS14665	COG0463	Glycosyl transferase, family 2
NI25_RS14695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS14695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS14710	COG1595	DNA-templated transcription, initiation
NI25_RS14720	COG1595	DNA-templated transcription, initiation
NI25_RS14750	COG2009	succinate dehydrogenase
NI25_RS14760	COG1053	succinate dehydrogenase
NI25_RS14785	COG1309	transcriptional regulator
NI25_RS14790	COG1408	metallophosphoesterase
NI25_RS14800	COG1686	Belongs to the peptidase S11 family
NI25_RS14820	COG0671	phosphoesterase, PA-phosphatase related
NI25_RS14840	COG0180	Tryptophanyl-tRNA synthetase
NI25_RS14850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NI25_RS14855	COG0754	glutathionylspermidine amidase activity
NI25_RS14865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NI25_RS14870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI25_RS14875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI25_RS14880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NI25_RS14890	COG4176	ABC-type proline glycine betaine transport system permease component
NI25_RS14895	COG0517	IMP dehydrogenase activity
NI25_RS14895	COG4175	Glycine betaine
NI25_RS14905	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS14910	COG0039	L-malate dehydrogenase activity
NI25_RS14925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NI25_RS14940	COG0515	serine threonine protein kinase
NI25_RS14940	COG2815	serine threonine protein kinase
NI25_RS14950	COG0138	bifunctional purine biosynthesis protein purh
NI25_RS14980	COG0045	succinate-CoA ligase (ADP-forming) activity
NI25_RS14990	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NI25_RS14995	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NI25_RS15000	COG0714	Associated with various cellular activities
NI25_RS15015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS15015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI25_RS15025	COG0739	heme binding
NI25_RS15055	COG2197	response regulator
NI25_RS15090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NI25_RS15090	COG0519	Catalyzes the synthesis of GMP from XMP
NI25_RS15110	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS15115	COG0515	serine threonine protein kinase
NI25_RS15125	COG0515	serine threonine protein kinase
NI25_RS15130	COG0515	serine threonine protein kinase
NI25_RS15130	COG2815	serine threonine protein kinase
NI25_RS15150	COG0516	GMP reductase activity
NI25_RS15160	COG1595	DNA-templated transcription, initiation
NI25_RS15175	COG0583	DNA-binding transcription factor activity
NI25_RS15185	COG4221	oxidoreductase activity
NI25_RS15205	COG0459	protein refolding
NI25_RS15210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NI25_RS15215	COG0726	polysaccharide deacetylase
NI25_RS15220	COG0726	polysaccharide deacetylase
NI25_RS15230	COG4941	Belongs to the sigma-70 factor family
NI25_RS15240	COG1316	TRANSCRIPTIONal
NI25_RS15255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NI25_RS15255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NI25_RS15275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NI25_RS15285	COG0456	acetyltransferase
NI25_RS15285	COG1214	PFAM Peptidase M22, glycoprotease
NI25_RS15300	COG0802	atpase or kinase
NI25_RS15310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NI25_RS15315	COG0736	holo-[acyl-carrier-protein] synthase activity
NI25_RS15320	COG1396	sequence-specific DNA binding
NI25_RS15325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NI25_RS15325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NI25_RS15335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NI25_RS15345	COG1072	(Pantothenic acid kinase))
NI25_RS15355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NI25_RS15360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NI25_RS15365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NI25_RS15380	COG0101	tRNA pseudouridine synthase activity
NI25_RS15385	COG0203	ribosomal protein L17
NI25_RS15395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NI25_RS15400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NI25_RS15405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NI25_RS15410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NI25_RS15420	COG0563	adenylate kinase activity
NI25_RS15425	COG0201	protein transport
NI25_RS15430	COG0200	Binds to the 23S rRNA
NI25_RS15435	COG1841	ribosomal large subunit assembly
NI25_RS15440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NI25_RS15445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NI25_RS15450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NI25_RS15455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NI25_RS15460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NI25_RS15465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NI25_RS15470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NI25_RS15475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NI25_RS15480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NI25_RS15485	COG0255	Belongs to the universal ribosomal protein uL29 family
NI25_RS15490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NI25_RS15495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NI25_RS15500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NI25_RS15505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NI25_RS15510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NI25_RS15515	COG0089	rRNA binding
NI25_RS15520	COG0088	Forms part of the polypeptide exit tunnel
NI25_RS15525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NI25_RS15530	COG0051	transcription antitermination factor activity, RNA binding
NI25_RS15575	COG1278	Cold shock
NI25_RS15580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NI25_RS15590	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS15630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NI25_RS15680	COG0583	DNA-binding transcription factor activity
NI25_RS15695	COG2197	response regulator
NI25_RS15705	COG1136	(ABC) transporter
NI25_RS15705	COG0577	efflux transmembrane transporter activity
NI25_RS15715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NI25_RS15720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NI25_RS15725	COG0049	tRNA binding
NI25_RS15730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NI25_RS15840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NI25_RS15845	COG0085	RNA polymerase activity
NI25_RS15850	COG0222	ribosome binding
NI25_RS15855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NI25_RS15870	COG0081	regulation of translation
NI25_RS15875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NI25_RS15880	COG0250	Participates in transcription elongation, termination and antitermination
NI25_RS15885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NI25_RS15895	COG0436	Aminotransferase
NI25_RS15900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI25_RS15915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NI25_RS15925	COG0477	Major facilitator Superfamily
NI25_RS15940	COG2226	methyltransferase
NI25_RS15950	COG2030	dehydratase
NI25_RS15955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NI25_RS15970	COG0402	S-adenosylhomocysteine deaminase activity
NI25_RS15985	COG1666	GTP binding
NI25_RS15990	COG2261	transglycosylase associated protein
NI25_RS16000	COG3304	Inner membrane component domain
NI25_RS16005	COG0501	Belongs to the peptidase M48B family
NI25_RS16010	COG1007	ATP synthesis coupled electron transport
NI25_RS16020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI25_RS16025	COG0713	ATP synthesis coupled electron transport
NI25_RS16035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS16040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NI25_RS16045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS16050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS16055	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS16075	COG0674	pyruvate-flavodoxin oxidoreductase activity
NI25_RS16075	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NI25_RS16080	COG1013	pyruvate-flavodoxin oxidoreductase activity
NI25_RS16085	COG0702	epimerase
NI25_RS16130	COG1196	nuclear chromosome segregation
NI25_RS16130	COG0741	lytic transglycosylase activity
NI25_RS16130	COG0739	heme binding
NI25_RS16205	COG1131	(ABC) transporter
NI25_RS16215	COG0142	geranyltranstransferase activity
NI25_RS16225	COG0561	phosphatase activity
NI25_RS16240	COG2188	Transcriptional regulator
NI25_RS16260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NI25_RS16265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NI25_RS16270	COG0514	ATP-dependent DNA helicase (RecQ)
NI25_RS16280	COG1007	ATP synthesis coupled electron transport
NI25_RS16290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI25_RS16295	COG0713	ATP synthesis coupled electron transport
NI25_RS16300	COG0839	Belongs to the complex I subunit 6 family
NI25_RS16305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS16310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NI25_RS16315	COG1034	ATP synthesis coupled electron transport
NI25_RS16320	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NI25_RS16330	COG0649	NAD binding
NI25_RS16335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS16340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI25_RS16355	COG0242	peptide deformylase activity
NI25_RS16375	COG2226	methyltransferase
NI25_RS16405	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NI25_RS16425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NI25_RS16425	COG0515	serine threonine protein kinase
NI25_RS16430	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NI25_RS16435	COG1278	Cold shock
NI25_RS16440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NI25_RS16465	COG1309	transcriptional regulator
NI25_RS16470	COG1301	dicarboxylic acid transport
NI25_RS16485	COG1573	uracil-dna glycosylase
NI25_RS16490	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NI25_RS16500	COG0163	prenyltransferase activity
NI25_RS16510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NI25_RS16550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NI25_RS16555	COG1333	cytochrome c biogenesis protein
NI25_RS16560	COG0785	Cytochrome C biogenesis protein
NI25_RS16565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NI25_RS16575	COG0406	alpha-ribazole phosphatase activity
NI25_RS16580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NI25_RS16620	COG0640	Transcriptional regulator
NI25_RS16625	COG0798	PFAM Bile acid sodium symporter
NI25_RS16635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI25_RS16705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS16710	COG1742	UPF0060 membrane protein
NI25_RS16725	COG3415	Transposase
NI25_RS16725	COG2801	Transposase and inactivated derivatives
NI25_RS16730	COG1690	Belongs to the RtcB family
NI25_RS16750	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NI25_RS16755	COG0018	arginyl-trna synthetase
NI25_RS16765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NI25_RS16785	COG0113	porphobilinogen synthase activity
NI25_RS16805	COG3321	synthase
NI25_RS16805	COG0604	alcohol dehydrogenase
NI25_RS16815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NI25_RS16815	COG1648	precorrin-2 dehydrogenase activity
NI25_RS16820	COG0181	hydroxymethylbilane synthase activity
NI25_RS16825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NI25_RS16830	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NI25_RS16880	COG0123	including yeast histone deacetylase and acetoin utilization protein
NI25_RS16890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NI25_RS16910	COG0180	Tryptophanyl-tRNA synthetase
NI25_RS16925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NI25_RS16935	COG0842	Transport permease protein
NI25_RS16935	COG1129	ABC transporter
NI25_RS16960	COG0515	serine threonine protein kinase
NI25_RS16960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NI25_RS16965	COG0129	dihydroxy-acid dehydratase activity
NI25_RS16975	COG1082	Xylose isomerase domain protein TIM barrel
NI25_RS16980	COG0248	Ppx GppA phosphatase
NI25_RS17000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NI25_RS17010	COG1194	a g-specific adenine glycosylase
NI25_RS17015	COG1595	DNA-templated transcription, initiation
NI25_RS17025	COG0745	RESPONSE REGULATOR receiver
NI25_RS17030	COG2205	protein histidine kinase activity
NI25_RS17040	COG0346	lactoylglutathione lyase activity
NI25_RS17050	COG1522	sequence-specific DNA binding
NI25_RS17070	COG0739	heme binding
NI25_RS17100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NI25_RS17120	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NI25_RS17130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NI25_RS17135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NI25_RS17160	COG1660	Displays ATPase and GTPase activities
NI25_RS17180	COG0649	NAD binding
NI25_RS17220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NI25_RS17240	COG0302	gtp cyclohydrolase
NI25_RS17255	COG0037	tRNA processing
NI25_RS17265	COG2027	D-alanyl-D-alanine carboxypeptidase
NI25_RS17270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NI25_RS17280	COG0586	Pfam SNARE associated Golgi protein
NI25_RS17285	COG0789	Transcriptional regulator
NI25_RS17290	COG0076	glutamate decarboxylase activity
NI25_RS17310	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS17335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NI25_RS17345	COG0254	rRNA binding
NI25_RS17350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NI25_RS17355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NI25_RS17360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NI25_RS17380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NI25_RS17380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NI25_RS17410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NI25_RS17415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NI25_RS17420	COG1754	DNA topoisomerase type I activity
NI25_RS17420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NI25_RS17440	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NI25_RS17445	COG2172	sigma factor antagonist activity
NI25_RS17450	COG1366	Belongs to the anti-sigma-factor antagonist family
NI25_RS17455	COG1111	helicase
NI25_RS17455	COG1205	dead DEAH box helicase
NI25_RS17515	COG0659	secondary active sulfate transmembrane transporter activity
NI25_RS17520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NI25_RS17525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NI25_RS17535	COG2267	carboxylic ester hydrolase activity
NI25_RS17545	COG0494	nUDIX hydrolase
NI25_RS17560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NI25_RS17570	COG0596	Alpha beta hydrolase
NI25_RS17575	COG0251	oxidation-reduction process
NI25_RS17590	COG0003	Pfam Anion-transporting ATPase
NI25_RS17605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NI25_RS17620	COG1408	metallophosphoesterase
NI25_RS17730	COG1309	transcriptional regulator
NI25_RS17745	COG0475	glutathione-regulated potassium exporter activity
NI25_RS17750	COG3263	regulation of cellular component size
NI25_RS17790	COG1595	DNA-templated transcription, initiation
NI25_RS17830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NI25_RS17835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NI25_RS17850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NI25_RS17855	COG1802	Transcriptional regulator
NI25_RS17870	COG1595	DNA-templated transcription, initiation
NI25_RS17885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NI25_RS17905	COG1131	(ABC) transporter
NI25_RS17910	COG3559	Exporter of polyketide antibiotics
NI25_RS17950	COG2197	response regulator
NI25_RS17955	COG4585	Histidine kinase
NI25_RS17960	COG2197	response regulator
NI25_RS17965	COG4585	Histidine kinase
NI25_RS17985	COG3844	kynureninase activity
NI25_RS18000	COG0477	Major facilitator Superfamily
NI25_RS18005	COG0191	fructose-bisphosphate aldolase activity
NI25_RS18010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NI25_RS18025	COG2197	response regulator
NI25_RS18030	COG4585	Histidine kinase
NI25_RS18035	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NI25_RS18060	COG0542	response to heat
NI25_RS18095	COG4213	ABC transporter substrate-binding protein
NI25_RS18100	COG0789	Transcriptional regulator
NI25_RS18105	COG0484	heat shock protein binding
NI25_RS18110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NI25_RS18115	COG0443	Heat shock 70 kDa protein
NI25_RS18120	COG0247	lactate metabolic process
NI25_RS18120	COG2181	nitrate reductase activity
NI25_RS18140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NI25_RS18145	COG0717	Belongs to the dCTP deaminase family
NI25_RS18270	COG0640	Transcriptional regulator
NI25_RS18275	COG2072	flavoprotein involved in K transport
NI25_RS18280	COG0798	PFAM Bile acid sodium symporter
NI25_RS18285	COG0640	Transcriptional regulator
NI25_RS18290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI25_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS18345	COG0778	Nitroreductase
NI25_RS18350	COG1309	transcriptional regulator
NI25_RS18375	COG1252	NADH dehydrogenase
NI25_RS18380	COG1595	DNA-templated transcription, initiation
NI25_RS18385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NI25_RS18390	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NI25_RS18395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NI25_RS18445	COG1278	Cold shock
NI25_RS18450	COG0513	Belongs to the DEAD box helicase family
NI25_RS18485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NI25_RS18490	COG5002	protein histidine kinase activity
NI25_RS18495	COG0745	RESPONSE REGULATOR receiver
NI25_RS18525	COG4585	Histidine kinase
NI25_RS18535	COG1136	(ABC) transporter
NI25_RS18535	COG0577	efflux transmembrane transporter activity
NI25_RS18550	COG1136	(ABC) transporter
NI25_RS18555	COG2197	response regulator
NI25_RS18560	COG4585	Histidine kinase
NI25_RS18605	COG0583	DNA-binding transcription factor activity
NI25_RS18630	COG1957	nucleoside hydrolase
NI25_RS18635	COG0366	Alpha amylase catalytic
NI25_RS18695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NI25_RS18705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NI25_RS18720	COG1741	Belongs to the pirin family
NI25_RS18730	COG1960	acyl-CoA dehydrogenase activity
NI25_RS18735	COG1362	aminopeptidase activity
NI25_RS18795	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI25_RS18800	COG0022	dehydrogenase e1 component
NI25_RS18820	COG0515	serine threonine protein kinase
NI25_RS18825	COG0515	serine threonine protein kinase
NI25_RS18840	COG0604	alcohol dehydrogenase
NI25_RS18840	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS18840	COG3321	synthase
NI25_RS18865	COG0746	molybdenum cofactor guanylyltransferase activity
NI25_RS18885	COG1522	sequence-specific DNA binding
NI25_RS18890	COG1309	transcriptional regulator
NI25_RS18895	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI25_RS18950	COG0745	RESPONSE REGULATOR receiver
NI25_RS19000	COG0475	glutathione-regulated potassium exporter activity
NI25_RS19030	COG4770	biotin carboxylase activity
NI25_RS19055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NI25_RS19075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI25_RS19085	COG3321	synthase
NI25_RS19085	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS19085	COG0604	alcohol dehydrogenase
NI25_RS19095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI25_RS19120	COG1716	ATPase activity
NI25_RS19125	COG1716	ATPase activity
NI25_RS19140	COG0768	penicillin binding
NI25_RS19145	COG0515	serine threonine protein kinase
NI25_RS19155	COG3764	Sortase (surface protein transpeptidase)
NI25_RS19160	COG3764	Sortase (surface protein transpeptidase)
NI25_RS19185	COG0705	Rhomboid family
NI25_RS19200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NI25_RS19215	COG0515	serine threonine protein kinase
NI25_RS19230	COG2188	Transcriptional regulator
NI25_RS19255	COG2319	Wd-40 repeat
NI25_RS19255	COG4249	Peptidase C14 caspase catalytic subunit p20
NI25_RS19270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NI25_RS19275	COG0187	DNA topoisomerase II activity
NI25_RS19280	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NI25_RS19285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NI25_RS19290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NI25_RS19295	COG0592	DNA-directed DNA polymerase activity
NI25_RS19300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NI25_RS19305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NI25_RS19310	COG0594	ribonuclease P activity
NI25_RS19315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NI25_RS19320	COG0706	membrane insertase activity
NI25_RS19330	COG0357	Ribosomal RNA small subunit methyltransferase G
NI25_RS19335	COG1192	Involved in chromosome partitioning
NI25_RS19350	COG3118	belongs to the thioredoxin family
NI25_RS19355	COG0492	ferredoxin-NADP+ reductase activity
NI25_RS19365	COG1595	DNA-templated transcription, initiation
NI25_RS19385	COG0617	tRNA 3'-terminal CCA addition
NI25_RS19410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NI25_RS19435	COG0360	Binds together with S18 to 16S ribosomal RNA
NI25_RS19440	COG0629	single-stranded DNA binding
NI25_RS19445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NI25_RS19450	COG0359	binds to the 23S rRNA
NI25_RS19460	COG0305	Participates in initiation and elongation during chromosome replication
NI25_RS19480	COG2814	Major facilitator Superfamily
NI25_RS19505	COG0626	cystathionine gamma-synthase activity
NI25_RS19510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI25_RS19515	COG1950	PFAM Membrane protein of
NI25_RS19520	COG0662	Cupin 2, conserved barrel domain protein
NI25_RS19545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NI25_RS19565	COG1609	Transcriptional regulator
NI25_RS19570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NI25_RS19580	COG1271	oxidase subunit
NI25_RS19585	COG1294	oxidase, subunit
NI25_RS19590	COG4988	ABC transporter
NI25_RS19600	COG0739	heme binding
NI25_RS19600	COG0741	lytic transglycosylase activity
NI25_RS19600	COG1196	nuclear chromosome segregation
NI25_RS19605	COG0561	phosphatase activity
NI25_RS19620	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NI25_RS19630	COG1131	(ABC) transporter
NI25_RS19650	COG0561	phosphatase activity
NI25_RS19655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NI25_RS19660	COG0077	Prephenate dehydratase
NI25_RS19665	COG2837	iron assimilation
NI25_RS19680	COG1999	signal sequence binding
NI25_RS19700	COG0006	proline dipeptidase activity
NI25_RS19720	COG0653	protein targeting
NI25_RS19735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NI25_RS19745	COG1309	transcriptional regulator
NI25_RS19785	COG1595	DNA-templated transcription, initiation
NI25_RS19790	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS19795	COG2814	Major facilitator Superfamily
NI25_RS19800	COG1309	transcriptional regulator
NI25_RS19805	COG0784	Response regulator, receiver
NI25_RS19830	COG0768	penicillin binding
NI25_RS19835	COG1733	regulation of RNA biosynthetic process
NI25_RS19850	COG0745	RESPONSE REGULATOR receiver
NI25_RS19855	COG2205	protein histidine kinase activity
NI25_RS19865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NI25_RS19870	COG0477	Major facilitator Superfamily
NI25_RS19880	COG3467	pyridoxamine 5'-phosphate
NI25_RS19905	COG0477	Major facilitator Superfamily
NI25_RS19920	COG1191	sigma factor activity
NI25_RS19925	COG1191	sigma factor activity
NI25_RS19960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NI25_RS20025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NI25_RS20095	COG1674	ftsk spoiiie
NI25_RS20155	COG0151	Belongs to the GarS family
NI25_RS20170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NI25_RS20180	COG2197	response regulator
NI25_RS20215	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NI25_RS20220	COG0047	phosphoribosylformylglycinamidine synthase activity
NI25_RS20225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NI25_RS20260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NI25_RS20295	COG1643	Atp-dependent helicase
NI25_RS20330	COG0513	Belongs to the DEAD box helicase family
NI25_RS20525	COG1609	Transcriptional regulator
NI25_RS20910	COG0039	L-malate dehydrogenase activity
NI25_RS20935	COG0582	viral genome integration into host DNA
NI25_RS20965	COG2860	membrane
NI25_RS20970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NI25_RS20970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NI25_RS21000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NI25_RS21010	COG0579	oxidoreductase
NI25_RS21045	COG1252	NADH dehydrogenase
NI25_RS21060	COG1846	Transcriptional regulator
NI25_RS21080	COG2197	response regulator
NI25_RS21085	COG4585	Histidine kinase
NI25_RS21125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NI25_RS21130	COG0741	lytic transglycosylase activity
NI25_RS21130	COG0739	heme binding
NI25_RS21130	COG1196	nuclear chromosome segregation
NI25_RS21135	COG0671	phosphoesterase, PA-phosphatase related
NI25_RS21140	COG0277	FAD linked oxidase domain protein
NI25_RS21150	COG1937	Protein conserved in bacteria
NI25_RS21160	COG0306	phosphate transporter
NI25_RS21165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NI25_RS21185	COG0406	alpha-ribazole phosphatase activity
NI25_RS21185	COG0494	nUDIX hydrolase
NI25_RS21195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NI25_RS21225	COG0456	acetyltransferase
NI25_RS21230	COG0737	Belongs to the 5'-nucleotidase family
NI25_RS21235	COG1733	regulation of RNA biosynthetic process
NI25_RS21250	COG0745	RESPONSE REGULATOR receiver
NI25_RS21255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NI25_RS21260	COG1609	Transcriptional regulator
NI25_RS21265	COG0745	RESPONSE REGULATOR receiver
NI25_RS21290	COG2897	thiosulfate sulfurtransferase activity
NI25_RS21315	COG1131	(ABC) transporter
NI25_RS21355	COG3485	protocatechuate 3,4-dioxygenase
NI25_RS21365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NI25_RS21370	COG1490	D-aminoacyl-tRNA deacylase activity
NI25_RS21385	COG4552	Acetyltransferase involved in intracellular survival and related
NI25_RS21405	COG2188	Transcriptional regulator
NI25_RS21410	COG0546	phosphoglycolate phosphatase activity
NI25_RS21415	COG0546	phosphoglycolate phosphatase activity
NI25_RS21465	COG0438	transferase activity, transferring glycosyl groups
NI25_RS21490	COG0588	phosphoglycerate mutase activity
NI25_RS21500	COG3321	synthase
NI25_RS21500	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS21500	COG0604	alcohol dehydrogenase
NI25_RS21520	COG2207	Transcriptional regulator
NI25_RS21520	COG3708	Transcriptional regulator
NI25_RS21540	COG5002	protein histidine kinase activity
NI25_RS21555	COG1329	Transcriptional regulator
NI25_RS21560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NI25_RS21565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NI25_RS21570	COG0215	cysteine-tRNA ligase activity
NI25_RS21595	COG3842	ATPase activity
NI25_RS21605	COG0596	Alpha beta hydrolase
NI25_RS21695	COG0464	growth
NI25_RS21710	COG1672	PFAM Archaeal ATPase
NI25_RS21710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NI25_RS21760	COG1309	transcriptional regulator
NI25_RS21765	COG1064	alcohol dehydrogenase
NI25_RS21770	COG0494	nUDIX hydrolase
NI25_RS21790	COG2197	response regulator
NI25_RS21835	COG1940	carbohydrate kinase activity
NI25_RS21840	COG1653	transport
NI25_RS21860	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NI25_RS21870	COG0463	Glycosyl transferase, family 2
NI25_RS21885	COG1278	Cold shock
NI25_RS21890	COG0459	protein refolding
NI25_RS21920	COG1309	transcriptional regulator
NI25_RS21925	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS21945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NI25_RS21950	COG1737	Transcriptional regulator
NI25_RS21990	COG3973	AAA domain
NI25_RS22000	COG1061	Type III restriction enzyme res subunit
NI25_RS22035	COG1278	Cold shock
NI25_RS22040	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NI25_RS22045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NI25_RS22055	COG2814	Major facilitator Superfamily
NI25_RS22070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NI25_RS22080	COG2252	PERMEase
NI25_RS22110	COG0667	Aldo Keto reductase
NI25_RS22150	COG4585	Histidine kinase
NI25_RS22155	COG2197	response regulator
NI25_RS22185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NI25_RS22190	COG0247	lactate metabolic process
NI25_RS22190	COG0277	FAD linked oxidase domain protein
NI25_RS22205	COG1733	regulation of RNA biosynthetic process
NI25_RS22215	COG2318	DinB family
NI25_RS22235	COG0515	serine threonine protein kinase
NI25_RS22235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NI25_RS22250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI25_RS22265	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS22285	COG0259	pyridoxamine-phosphate oxidase activity
NI25_RS22305	COG4821	SIS domain
NI25_RS22315	COG2945	thiolester hydrolase activity
NI25_RS22315	COG0596	Alpha beta hydrolase
NI25_RS22325	COG1131	(ABC) transporter
NI25_RS22385	COG1595	DNA-templated transcription, initiation
NI25_RS22390	COG1366	Belongs to the anti-sigma-factor antagonist family
NI25_RS22410	COG2271	Major facilitator Superfamily
NI25_RS22420	COG2072	flavoprotein involved in K transport
NI25_RS22430	COG0259	pyridoxamine-phosphate oxidase activity
NI25_RS22440	COG1309	transcriptional regulator
NI25_RS22450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NI25_RS22450	COG0515	serine threonine protein kinase
NI25_RS22465	COG3903	Transcriptional regulator
NI25_RS22465	COG3629	intracellular signal transduction
NI25_RS22485	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NI25_RS22525	COG1686	Belongs to the peptidase S11 family
NI25_RS22550	COG0386	Belongs to the glutathione peroxidase family
NI25_RS22575	COG0110	maltose O-acetyltransferase activity
NI25_RS22580	COG4257	antibiotic catabolic process
NI25_RS22585	COG1309	transcriptional regulator
NI25_RS22590	COG0477	Major facilitator Superfamily
NI25_RS22595	COG4941	Belongs to the sigma-70 factor family
NI25_RS22600	COG3795	YCII-related domain
NI25_RS22615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NI25_RS22625	COG0577	efflux transmembrane transporter activity
NI25_RS22625	COG1136	(ABC) transporter
NI25_RS22755	COG4974	Belongs to the 'phage' integrase family
NI25_RS22765	COG1414	Transcriptional regulator
NI25_RS22785	COG1846	Transcriptional regulator
NI25_RS22790	COG3384	dioxygenase
NI25_RS22795	COG1247	-acetyltransferase
NI25_RS22800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NI25_RS22815	COG0477	Major facilitator Superfamily
NI25_RS22820	COG1349	DNA-binding transcription factor activity
NI25_RS22830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NI25_RS22830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NI25_RS22830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NI25_RS22860	COG1970	mechanosensitive ion channel activity
NI25_RS22870	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NI25_RS22890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NI25_RS22895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NI25_RS22905	COG0315	cyclic pyranopterin monophosphate synthase activity
NI25_RS22910	COG0521	Mo-molybdopterin cofactor biosynthetic process
NI25_RS22910	COG0315	cyclic pyranopterin monophosphate synthase activity
NI25_RS22915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NI25_RS22935	COG0708	Exodeoxyribonuclease III
NI25_RS22945	COG2072	flavoprotein involved in K transport
NI25_RS22950	COG2267	carboxylic ester hydrolase activity
NI25_RS22965	COG0793	Belongs to the peptidase S41A family
NI25_RS22965	COG4946	Tricorn protease homolog
NI25_RS22975	COG2409	Drug exporters of the RND superfamily
NI25_RS22980	COG0442	prolyl-tRNA aminoacylation
NI25_RS22995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NI25_RS23000	COG1122	ATPase activity
NI25_RS23010	COG0310	cobalt ion transport
NI25_RS23070	COG1674	ftsk spoiiie
NI25_RS23100	COG2188	Transcriptional regulator
NI25_RS23140	COG0084	hydrolase, TatD family'
NI25_RS23145	COG1388	LysM domain
NI25_RS23150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NI25_RS23155	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NI25_RS23160	COG0488	(ABC) transporter
NI25_RS23200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NI25_RS23215	COG2197	response regulator
NI25_RS23225	COG4106	trans-aconitate 2-methyltransferase activity
NI25_RS23235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NI25_RS23240	COG1309	transcriptional regulator
NI25_RS23250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NI25_RS23260	COG0193	aminoacyl-tRNA hydrolase activity
NI25_RS23265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NI25_RS23270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NI25_RS23275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NI25_RS23290	COG4585	Histidine kinase
NI25_RS23320	COG1136	(ABC) transporter
NI25_RS23325	COG0577	efflux transmembrane transporter activity
NI25_RS23395	COG0148	phosphopyruvate hydratase activity
NI25_RS23415	COG1252	NADH dehydrogenase
NI25_RS23420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NI25_RS23425	COG0577	efflux transmembrane transporter activity
NI25_RS23425	COG1136	(ABC) transporter
NI25_RS23430	COG1136	(ABC) transporter
NI25_RS23465	COG0183	Belongs to the thiolase family
NI25_RS23470	COG2755	lipolytic protein G-D-S-L family
NI25_RS23500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NI25_RS23505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NI25_RS23515	COG1228	amidohydrolase
NI25_RS23525	COG1191	sigma factor activity
NI25_RS23530	COG1366	Belongs to the anti-sigma-factor antagonist family
NI25_RS23560	COG3104	oligopeptide transport
NI25_RS23565	COG0745	RESPONSE REGULATOR receiver
NI25_RS23570	COG2205	protein histidine kinase activity
NI25_RS23585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NI25_RS23610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NI25_RS23630	COG1316	TRANSCRIPTIONal
NI25_RS23645	COG1316	TRANSCRIPTIONal
NI25_RS23650	COG1316	TRANSCRIPTIONal
NI25_RS23655	COG1316	TRANSCRIPTIONal
NI25_RS23660	COG1316	TRANSCRIPTIONal
NI25_RS23665	COG1316	TRANSCRIPTIONal
NI25_RS23690	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NI25_RS23690	COG0778	Nitroreductase
NI25_RS23695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NI25_RS23730	COG1620	l-lactate permease
NI25_RS23740	COG3415	Transposase
NI25_RS23740	COG2801	Transposase and inactivated derivatives
NI25_RS23745	COG2835	tetraacyldisaccharide 4'-kinase activity
NI25_RS23755	COG1482	cell wall glycoprotein biosynthetic process
NI25_RS23765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NI25_RS23805	COG0714	Associated with various cellular activities
NI25_RS23825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NI25_RS23830	COG0745	RESPONSE REGULATOR receiver
NI25_RS23835	COG5002	protein histidine kinase activity
NI25_RS23835	COG5000	phosphorelay sensor kinase activity
NI25_RS23840	COG0823	Involved in the tonB-independent uptake of proteins
NI25_RS23850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NI25_RS23855	COG2197	response regulator
NI25_RS23860	COG3214	Protein conserved in bacteria
NI25_RS23870	COG0653	protein targeting
NI25_RS23900	COG2902	Dehydrogenase
NI25_RS23905	COG1216	Glycosyl transferase, family 2
NI25_RS23910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NI25_RS23915	COG1134	teichoic acid transport
NI25_RS23925	COG1309	transcriptional regulator
NI25_RS23940	COG1846	Transcriptional regulator
NI25_RS23945	COG1764	response to oxidative stress
NI25_RS23960	COG1216	Glycosyl transferase, family 2
NI25_RS23965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NI25_RS23970	COG1216	Glycosyl transferase, family 2
NI25_RS23975	COG0395	ABC-type sugar transport system, permease component
NI25_RS23980	COG1175	transmembrane transport
NI25_RS23990	COG1674	ftsk spoiiie
NI25_RS23995	COG0515	serine threonine protein kinase
NI25_RS24000	COG0515	serine threonine protein kinase
NI25_RS24005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NI25_RS24020	COG2884	Cell division ATP-binding protein ftsE
NI25_RS24030	COG0793	Belongs to the peptidase S41A family
NI25_RS24035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NI25_RS24075	COG2223	nitrite transmembrane transporter activity
NI25_RS24105	COG3973	AAA domain
NI25_RS24115	COG0776	regulation of translation
NI25_RS24120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NI25_RS24125	COG1678	Uncharacterized ACR, COG1678
NI25_RS24140	COG1175	transmembrane transport
NI25_RS24145	COG0395	ABC-type sugar transport system, permease component
NI25_RS24150	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NI25_RS24200	COG3480	Lon protease (S16) C-terminal proteolytic domain
NI25_RS24210	COG1174	glycine betaine transport
NI25_RS24230	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NI25_RS24240	COG0277	FAD linked oxidase domain protein
NI25_RS24255	COG1714	RDD family
NI25_RS24275	COG1335	isochorismatase
NI25_RS24285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NI25_RS24295	COG1113	amino acid transport
NI25_RS24320	COG1234	tRNA 3'-trailer cleavage
NI25_RS24325	COG1263	PTS System
NI25_RS24330	COG1263	PTS System
NI25_RS24335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NI25_RS24340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NI25_RS24350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NI25_RS24380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NI25_RS24395	COG4555	ABC transporter
NI25_RS24410	COG2733	membrane
NI25_RS24430	COG2267	carboxylic ester hydrolase activity
NI25_RS24435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI25_RS24480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NI25_RS24485	COG0477	Major facilitator Superfamily
NI25_RS24500	COG2264	protein methyltransferase activity
NI25_RS24560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NI25_RS24570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NI25_RS24575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NI25_RS24580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NI25_RS24625	COG1619	proteins homologs of microcin C7 resistance protein MccF
NI25_RS24660	COG4702	Belongs to the UPF0303 family
NI25_RS24665	COG0673	inositol 2-dehydrogenase activity
NI25_RS24725	COG3397	chitin binding
NI25_RS24740	COG1126	abc transporter atp-binding protein
NI25_RS24745	COG0765	amino acid transport
NI25_RS24750	COG0765	amino acid transport
NI25_RS24755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NI25_RS24820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS24835	COG2223	nitrite transmembrane transporter activity
NI25_RS24850	COG0477	Major facilitator Superfamily
NI25_RS24855	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS24870	COG2267	carboxylic ester hydrolase activity
NI25_RS24880	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS24910	COG1846	Transcriptional regulator
NI25_RS24950	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NI25_RS24960	COG0745	RESPONSE REGULATOR receiver
NI25_RS24980	COG0395	ABC-type sugar transport system, permease component
NI25_RS25005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NI25_RS25010	COG4977	sequence-specific DNA binding
NI25_RS25020	COG0589	response to stress
NI25_RS25025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NI25_RS25055	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NI25_RS25075	COG1960	acyl-CoA dehydrogenase activity
NI25_RS25090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI25_RS25095	COG1309	transcriptional regulator
NI25_RS25105	COG1946	Acyl-CoA thioesterase
NI25_RS25125	COG0028	Belongs to the TPP enzyme family
NI25_RS25140	COG2356	endonuclease I
NI25_RS25175	COG1472	Belongs to the glycosyl hydrolase 3 family
NI25_RS25200	COG1609	Transcriptional regulator
NI25_RS25205	COG0673	inositol 2-dehydrogenase activity
NI25_RS25255	COG1869	D-ribose catabolic process
NI25_RS25260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NI25_RS25265	COG1879	ABC-type sugar transport system periplasmic component
NI25_RS25270	COG1129	ABC transporter
NI25_RS25275	COG1609	Transcriptional regulator
NI25_RS25315	COG4122	O-methyltransferase activity
NI25_RS25320	COG2207	Transcriptional regulator
NI25_RS25325	COG0110	maltose O-acetyltransferase activity
NI25_RS25335	COG1595	DNA-templated transcription, initiation
NI25_RS25340	COG0640	Transcriptional regulator
NI25_RS25375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NI25_RS25400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NI25_RS25430	COG1131	(ABC) transporter
NI25_RS25490	COG0438	transferase activity, transferring glycosyl groups
NI25_RS25510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NI25_RS25515	COG0438	transferase activity, transferring glycosyl groups
NI25_RS25545	COG2304	oxidoreductase activity
NI25_RS25560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NI25_RS25650	COG2188	Transcriptional regulator
NI25_RS25670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NI25_RS25675	COG0629	single-stranded DNA binding
NI25_RS25710	COG1136	(ABC) transporter
NI25_RS25710	COG0577	efflux transmembrane transporter activity
NI25_RS25730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI25_RS25750	COG0515	serine threonine protein kinase
NI25_RS25760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NI25_RS25775	COG1486	melibiose metabolic process
NI25_RS25780	COG0395	ABC-type sugar transport system, permease component
NI25_RS25785	COG1175	transmembrane transport
NI25_RS25790	COG1653	transport
NI25_RS25820	COG1136	(ABC) transporter
NI25_RS25845	COG0668	transmembrane transport
NI25_RS25850	COG1846	Transcriptional regulator
NI25_RS25855	COG0697	spore germination
NI25_RS25915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NI25_RS25920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NI25_RS25930	COG1268	BioY protein
NI25_RS25935	COG1113	amino acid transport
NI25_RS25940	COG0698	ribose 5-phosphate isomerase
NI25_RS25950	COG4552	Acetyltransferase involved in intracellular survival and related
NI25_RS25965	COG3594	Acyltransferase
NI25_RS25980	COG2188	Transcriptional regulator
NI25_RS26015	COG0270	DNA (cytosine-5-)-methyltransferase activity
NI25_RS26045	COG0544	peptidyl-prolyl cis-trans isomerase activity
NI25_RS26050	COG0740	serine-type endopeptidase activity
NI25_RS26055	COG0740	serine-type endopeptidase activity
NI25_RS26060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NI25_RS26070	COG0525	valine-tRNA ligase activity
NI25_RS26075	COG0285	dihydrofolate synthase activity
NI25_RS26085	COG0105	UTP biosynthetic process
NI25_RS26090	COG1077	Cell shape determining protein MreB Mrl
NI25_RS26105	COG0768	penicillin binding
NI25_RS26110	COG0772	Belongs to the SEDS family
NI25_RS26130	COG1530	ribonuclease E activity
NI25_RS26135	COG0371	Dehydrogenase
NI25_RS26140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NI25_RS26145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NI25_RS26150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NI25_RS26180	COG0438	transferase activity, transferring glycosyl groups
NI25_RS26185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NI25_RS26190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NI25_RS26200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NI25_RS26210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NI25_RS26225	COG0501	Belongs to the peptidase M48B family
NI25_RS26240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NI25_RS26250	COG0799	negative regulation of ribosome biogenesis
NI25_RS26255	COG0588	phosphoglycerate mutase activity
NI25_RS26275	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NI25_RS26285	COG0495	leucyl-tRNA aminoacylation
NI25_RS26295	COG1307	EDD domain protein, DegV family
NI25_RS26300	COG1555	photosystem II stabilization
NI25_RS26305	COG1234	tRNA 3'-trailer cleavage
NI25_RS26325	COG2353	YceI-like domain
NI25_RS26340	COG0268	Binds directly to 16S ribosomal RNA
NI25_RS26345	COG0481	GTPase activity
NI25_RS26375	COG1420	regulation of RNA biosynthetic process
NI25_RS26380	COG0484	heat shock protein binding
NI25_RS26400	COG4946	Tricorn protease homolog
NI25_RS26400	COG0793	Belongs to the peptidase S41A family
NI25_RS26405	COG0537	adenosine 5'-monophosphoramidase activity
NI25_RS26410	COG1234	tRNA 3'-trailer cleavage
NI25_RS26415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI25_RS26425	COG4948	Mandelate Racemase Muconate Lactonizing
NI25_RS26430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NI25_RS26435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NI25_RS26455	COG2315	Protein conserved in bacteria
NI25_RS26465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NI25_RS26490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NI25_RS26535	COG2409	Drug exporters of the RND superfamily
NI25_RS26545	COG2197	response regulator
NI25_RS26585	COG1381	Involved in DNA repair and RecF pathway recombination
NI25_RS26590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NI25_RS26600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NI25_RS26605	COG1121	(ABC) transporter
NI25_RS26610	COG3443	Belongs to the bacterial solute-binding protein 9 family
NI25_RS26610	COG0803	Belongs to the bacterial solute-binding protein 9 family
NI25_RS26615	COG0423	glycine-tRNA ligase activity
NI25_RS26625	COG0477	Major facilitator Superfamily
NI25_RS26660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NI25_RS26660	COG0574	Belongs to the PEP-utilizing enzyme family
NI25_RS26665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NI25_RS26685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NI25_RS26685	COG2146	nitrite reductase [NAD(P)H] activity
NI25_RS26720	COG0583	DNA-binding transcription factor activity
NI25_RS26735	COG0243	molybdopterin cofactor binding
NI25_RS26740	COG2949	membrane
NI25_RS26750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NI25_RS26760	COG0358	DNA primase activity
NI25_RS26765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NI25_RS26780	COG1070	Carbohydrate kinase
NI25_RS26820	COG0464	growth
NI25_RS26830	COG1674	ftsk spoiiie
NI25_RS26890	COG1077	Cell shape determining protein MreB Mrl
NI25_RS26895	COG1404	Belongs to the peptidase S8 family
NI25_RS26900	COG0825	malonyl-CoA metabolic process
NI25_RS26900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NI25_RS26905	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS26910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS26945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NI25_RS26950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NI25_RS26955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NI25_RS26965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NI25_RS26970	COG1733	regulation of RNA biosynthetic process
NI25_RS26980	COG1181	Belongs to the D-alanine--D-alanine ligase family
NI25_RS26995	COG1414	Transcriptional regulator
NI25_RS27000	COG3386	PFAM SMP-30 Gluconolaconase
NI25_RS27030	COG1175	transmembrane transport
NI25_RS27035	COG0395	ABC-type sugar transport system, permease component
NI25_RS27055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NI25_RS27060	COG3507	Belongs to the glycosyl hydrolase 43 family
NI25_RS27095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NI25_RS27120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NI25_RS27155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NI25_RS27165	COG4214	carbohydrate transport
NI25_RS27170	COG1129	ABC transporter
NI25_RS27205	COG2130	NADP-dependent
NI25_RS27210	COG1764	response to oxidative stress
NI25_RS27240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NI25_RS27245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI25_RS27250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI25_RS27280	COG0789	Transcriptional regulator
NI25_RS27285	COG0667	Aldo Keto reductase
NI25_RS27300	COG1309	transcriptional regulator
NI25_RS27305	COG0477	Major facilitator Superfamily
NI25_RS27310	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NI25_RS27355	COG1358	cellular component organization or biogenesis
NI25_RS27365	COG0586	Pfam SNARE associated Golgi protein
NI25_RS27370	COG4585	Histidine kinase
NI25_RS27375	COG2201	protein-glutamate methylesterase activity
NI25_RS27480	COG4122	O-methyltransferase activity
NI25_RS27515	COG3409	Peptidoglycan-binding domain 1 protein
NI25_RS27565	COG3845	ABC transporter
NI25_RS27580	COG1657	PFAM Prenyltransferase squalene oxidase
NI25_RS27585	COG1309	transcriptional regulator
NI25_RS27590	COG0438	transferase activity, transferring glycosyl groups
NI25_RS27615	COG0860	N-Acetylmuramoyl-L-alanine amidase
NI25_RS27615	COG2247	cell wall binding repeat
NI25_RS27625	COG0477	Major facilitator Superfamily
NI25_RS27635	COG2197	response regulator
NI25_RS27640	COG4585	Histidine kinase
NI25_RS27650	COG1131	(ABC) transporter
NI25_RS27655	COG2030	dehydratase
NI25_RS27670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NI25_RS27685	COG0800	Aldolase
NI25_RS27690	COG3022	response to hydroperoxide
NI25_RS27725	COG1280	lysine exporter protein (LysE YggA)
NI25_RS27740	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS27785	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS27790	COG3540	Alkaline phosphatase
NI25_RS27800	COG2814	Major facilitator Superfamily
NI25_RS27805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NI25_RS27815	COG2197	response regulator
NI25_RS27835	COG0672	)-iron permease
NI25_RS27840	COG2837	iron assimilation
NI25_RS27850	COG1120	ATPase activity
NI25_RS27855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI25_RS27880	COG0384	phenazine biosynthesis protein PhzF
NI25_RS27920	COG1994	Peptidase M50
NI25_RS27940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NI25_RS27950	COG2814	Major facilitator Superfamily
NI25_RS28065	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NI25_RS28070	COG0174	glutamine synthetase
NI25_RS28090	COG4115	mRNA cleavage
NI25_RS28095	COG2161	toxin-antitoxin pair type II binding
NI25_RS28100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NI25_RS28110	COG1609	Transcriptional regulator
NI25_RS28115	COG1653	transport
NI25_RS28120	COG1175	transmembrane transport
NI25_RS28125	COG3833	ABC-type maltose transport systems, permease component
NI25_RS28130	COG0366	Alpha amylase catalytic
NI25_RS28135	COG1556	Lactate utilization protein
NI25_RS28140	COG1139	Iron-sulfur cluster binding protein
NI25_RS28145	COG0247	lactate metabolic process
NI25_RS28150	COG1620	l-lactate permease
NI25_RS28175	COG1309	transcriptional regulator
NI25_RS28205	COG2197	response regulator
NI25_RS28220	COG0745	RESPONSE REGULATOR receiver
NI25_RS28240	COG1846	Transcriptional regulator
NI25_RS28280	COG0501	Belongs to the peptidase M48B family
NI25_RS28285	COG1733	regulation of RNA biosynthetic process
NI25_RS28290	COG0702	epimerase
NI25_RS28300	COG0174	glutamine synthetase
NI25_RS28320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NI25_RS28325	COG0321	lipoyl(octanoyl) transferase activity
NI25_RS28340	COG1090	epimerase
NI25_RS28370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NI25_RS28380	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI25_RS28385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NI25_RS28390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NI25_RS28400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NI25_RS28410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NI25_RS28430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NI25_RS28435	COG2226	methyltransferase
NI25_RS28455	COG4585	Histidine kinase
NI25_RS28460	COG2197	response regulator
NI25_RS28465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NI25_RS28475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NI25_RS28495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NI25_RS28505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NI25_RS28510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NI25_RS28520	COG1376	ErfK ybiS ycfS ynhG family protein
NI25_RS28530	COG1845	cytochrome c oxidase, subunit III
NI25_RS28535	COG2010	Cytochrome c
NI25_RS28540	COG0723	plastoquinol--plastocyanin reductase activity
NI25_RS28545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NI25_RS28550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NI25_RS28555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NI25_RS28560	COG1929	Belongs to the glycerate kinase type-1 family
NI25_RS28570	COG0745	RESPONSE REGULATOR receiver
NI25_RS28575	COG2205	protein histidine kinase activity
NI25_RS28625	COG0438	transferase activity, transferring glycosyl groups
NI25_RS28645	COG0003	Pfam Anion-transporting ATPase
NI25_RS28655	COG1940	carbohydrate kinase activity
NI25_RS28680	COG4585	Histidine kinase
NI25_RS28685	COG2197	response regulator
NI25_RS28690	COG0205	6-phosphofructokinase activity
NI25_RS28695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NI25_RS28710	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NI25_RS28720	COG2193	ferroxidase activity
NI25_RS28725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NI25_RS28730	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NI25_RS28735	COG2815	serine threonine protein kinase
NI25_RS28735	COG0515	serine threonine protein kinase
NI25_RS28740	COG2022	thiamine diphosphate biosynthetic process
NI25_RS28750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI25_RS28750	COG2022	thiamine diphosphate biosynthetic process
NI25_RS28765	COG0352	thiamine-phosphate diphosphorylase activity
NI25_RS28785	COG1309	transcriptional regulator
NI25_RS28815	COG0714	Associated with various cellular activities
NI25_RS28825	COG0275	rRNA processing
NI25_RS28835	COG0768	penicillin binding
NI25_RS28840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NI25_RS28850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NI25_RS28855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NI25_RS28865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NI25_RS28870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NI25_RS28875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NI25_RS28880	COG1496	oxidoreductase activity
NI25_RS28890	COG1799	cell septum assembly
NI25_RS28900	COG3599	regulation of cell shape
NI25_RS28905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NI25_RS28915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NI25_RS28930	COG0025	NhaP-type Na H and K H
NI25_RS28965	COG0587	DNA-directed DNA polymerase activity
NI25_RS28975	COG1432	Conserved Protein
NI25_RS28995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NI25_RS29015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NI25_RS29020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NI25_RS29025	COG0131	Imidazoleglycerol-phosphate dehydratase
NI25_RS29030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NI25_RS29035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NI25_RS29040	COG0251	oxidation-reduction process
NI25_RS29045	COG0107	imidazoleglycerol-phosphate synthase activity
NI25_RS29060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NI25_RS29085	COG0134	indole-3-glycerol-phosphate synthase activity
NI25_RS29095	COG0133	tryptophan synthase activity
NI25_RS29100	COG0159	tryptophan synthase activity
NI25_RS29110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NI25_RS29115	COG2301	Belongs to the HpcH HpaI aldolase family
NI25_RS29120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NI25_RS29150	COG0067	glutamate synthase
NI25_RS29150	COG0070	glutamate synthase
NI25_RS29150	COG0069	glutamate synthase activity
NI25_RS29170	COG2304	oxidoreductase activity
NI25_RS29185	COG0287	Prephenate dehydrogenase
NI25_RS29185	COG1605	Chorismate mutase
NI25_RS29205	COG0737	Belongs to the 5'-nucleotidase family
NI25_RS29260	COG2050	protein possibly involved in aromatic compounds catabolism
NI25_RS29285	COG1643	Atp-dependent helicase
NI25_RS29295	COG0539	negative regulation of cytoplasmic translation
NI25_RS29305	COG0237	dephospho-CoA kinase activity
NI25_RS29320	COG2226	methyltransferase
NI25_RS29340	COG2267	carboxylic ester hydrolase activity
NI25_RS29365	COG0402	S-adenosylhomocysteine deaminase activity
NI25_RS29415	COG2226	methyltransferase
NI25_RS29420	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NI25_RS29420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NI25_RS29425	COG2313	pseudouridylate synthase activity
NI25_RS29435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NI25_RS29440	COG0584	glycerophosphoryl diester phosphodiesterase
NI25_RS29450	COG0556	nucleotide-excision repair
NI25_RS29470	COG0387	Pfam Sodium calcium exchanger
NI25_RS29475	COG1619	proteins homologs of microcin C7 resistance protein MccF
NI25_RS29480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NI25_RS29495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NI25_RS29520	COG0322	excinuclease ABC activity
NI25_RS29525	COG1660	Displays ATPase and GTPase activities
NI25_RS29530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NI25_RS29535	COG1481	regulation of sporulation
NI25_RS29545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NI25_RS29550	COG0126	phosphoglycerate kinase activity
NI25_RS29555	COG0149	triose-phosphate isomerase activity
NI25_RS29560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NI25_RS29570	COG0166	Belongs to the GPI family
NI25_RS29580	COG0577	efflux transmembrane transporter activity
NI25_RS29580	COG1136	(ABC) transporter
NI25_RS29585	COG1695	Transcriptional regulator
NI25_RS29590	COG1653	transport
NI25_RS29595	COG0366	Alpha amylase catalytic
NI25_RS29600	COG1653	transport
NI25_RS29605	COG1175	transmembrane transport
NI25_RS29610	COG0395	ABC-type sugar transport system, permease component
NI25_RS29615	COG0363	glucosamine-6-phosphate deaminase activity
NI25_RS29630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NI25_RS29640	COG0109	protoheme IX farnesyltransferase activity
NI25_RS29670	COG1131	(ABC) transporter
NI25_RS29675	COG2746	aminoglycoside 3-N-acetyltransferase activity
NI25_RS29690	COG0719	Fe-S assembly protein
NI25_RS29700	COG0396	ATPase activity
NI25_RS29705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NI25_RS29710	COG0822	iron-sulfur transferase activity
NI25_RS29715	COG2151	metal-sulfur cluster biosynthetic enzyme
NI25_RS29720	COG2076	Multidrug Resistance protein
NI25_RS29725	COG3226	Transcriptional regulator
NI25_RS29730	COG2171	N-acyltransferase activity
NI25_RS29745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NI25_RS29785	COG1802	Transcriptional regulator
NI25_RS29795	COG1309	transcriptional regulator
NI25_RS29830	COG1349	DNA-binding transcription factor activity
NI25_RS29835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NI25_RS29840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NI25_RS29865	COG1802	Transcriptional regulator
NI25_RS29880	COG1175	transmembrane transport
NI25_RS29885	COG0395	ABC-type sugar transport system, permease component
NI25_RS29900	COG3507	Belongs to the glycosyl hydrolase 43 family
NI25_RS29910	COG2755	lipolytic protein G-D-S-L family
NI25_RS29915	COG3866	Pectate lyase
NI25_RS29920	COG4677	pectinesterase activity
NI25_RS29935	COG1595	DNA-templated transcription, initiation
NI25_RS29940	COG0768	penicillin binding
NI25_RS29945	COG2197	response regulator
NI25_RS29950	COG4585	Histidine kinase
NI25_RS29965	COG1414	Transcriptional regulator
NI25_RS29990	COG5285	phytanoyl-CoA dioxygenase
NI25_RS29995	COG1917	Cupin 2, conserved barrel domain protein
NI25_RS30000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NI25_RS30005	COG0456	acetyltransferase
NI25_RS30010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NI25_RS30035	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NI25_RS30065	COG1797	cobyrinic acid a,c-diamide synthase activity
NI25_RS30085	COG1492	cobalamin metabolic process
NI25_RS30090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NI25_RS30105	COG0235	Class ii aldolase
NI25_RS30125	COG0488	(ABC) transporter
NI25_RS30170	COG3387	PFAM Glycoside hydrolase 15-related
NI25_RS30200	COG1404	Belongs to the peptidase S8 family
NI25_RS30210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NI25_RS30215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NI25_RS30235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NI25_RS30250	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS30260	COG2186	Transcriptional regulator
NI25_RS30285	COG0560	Phosphoserine phosphatase
NI25_RS30285	COG3830	Belongs to the UPF0237 family
NI25_RS30295	COG1131	(ABC) transporter
NI25_RS30295	COG1716	ATPase activity
NI25_RS30295	COG0842	Transport permease protein
NI25_RS30305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NI25_RS30310	COG4221	oxidoreductase activity
NI25_RS30320	COG2197	response regulator
NI25_RS30335	COG1119	ATPase activity
NI25_RS30355	COG1881	PFAM PEBP family protein
NI25_RS30365	COG2094	Belongs to the DNA glycosylase MPG family
NI25_RS30400	COG0647	UMP catabolic process
NI25_RS30405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI25_RS30410	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI25_RS30415	COG1120	ATPase activity
NI25_RS30435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NI25_RS30440	COG0497	DNA recombination
NI25_RS30455	COG3387	PFAM Glycoside hydrolase 15-related
NI25_RS30460	COG0504	CTP synthase activity
NI25_RS30465	COG0494	nUDIX hydrolase
NI25_RS30475	COG0686	Belongs to the AlaDH PNT family
NI25_RS30490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NI25_RS30495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NI25_RS30500	COG1187	pseudouridine synthase activity
NI25_RS30510	COG1397	ADP-ribosylglycohydrolase
NI25_RS30515	COG3541	Predicted nucleotidyltransferase
NI25_RS30540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NI25_RS30550	COG1160	GTP binding
NI25_RS30575	COG0671	phosphoesterase, PA-phosphatase related
NI25_RS30585	COG0477	Major facilitator Superfamily
NI25_RS30590	COG1960	acyl-CoA dehydrogenase activity
NI25_RS30595	COG1799	cell septum assembly
NI25_RS30620	COG0587	DNA-directed DNA polymerase activity
NI25_RS30630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NI25_RS30630	COG0662	Cupin 2, conserved barrel domain protein
NI25_RS30660	COG2226	methyltransferase
NI25_RS30675	COG1725	Transcriptional regulator
NI25_RS30690	COG2755	lipolytic protein G-D-S-L family
NI25_RS30695	COG1595	DNA-templated transcription, initiation
NI25_RS30730	COG2188	Transcriptional regulator
NI25_RS30735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NI25_RS30745	COG1309	transcriptional regulator
NI25_RS30750	COG0243	molybdopterin cofactor binding
NI25_RS30755	COG2851	Citrate transporter
NI25_RS30770	COG3842	ATPase activity
NI25_RS30790	COG0640	Transcriptional regulator
NI25_RS30800	COG1960	acyl-CoA dehydrogenase activity
NI25_RS30840	COG3876	Protein conserved in bacteria
NI25_RS30855	COG0583	DNA-binding transcription factor activity
NI25_RS30875	COG2149	membrane
NI25_RS30880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NI25_RS30900	COG1063	alcohol dehydrogenase
NI25_RS30905	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS30915	COG3265	gluconokinase activity
NI25_RS30925	COG3012	SEC-C Motif Domain Protein
NI25_RS30935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NI25_RS30965	COG0667	Aldo Keto reductase
NI25_RS30970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS30980	COG0598	Magnesium transport protein CorA
NI25_RS30985	COG0588	phosphoglycerate mutase activity
NI25_RS31000	COG0215	cysteine-tRNA ligase activity
NI25_RS31010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NI25_RS31015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NI25_RS31020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NI25_RS31025	COG1414	Transcriptional regulator
NI25_RS31030	COG0646	methionine synthase
NI25_RS31030	COG1410	methionine synthase
NI25_RS31035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NI25_RS31040	COG4166	transmembrane transport
NI25_RS31045	COG2197	response regulator
NI25_RS31055	COG0517	IMP dehydrogenase activity
NI25_RS31055	COG1994	Peptidase M50
NI25_RS31075	COG1222	aaa ATPase
NI25_RS31080	COG4122	O-methyltransferase activity
NI25_RS31095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NI25_RS31100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NI25_RS31105	COG1609	Transcriptional regulator
NI25_RS31115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NI25_RS31120	COG0545	Peptidyl-prolyl cis-trans isomerase
NI25_RS31150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NI25_RS31155	COG0805	protein transport
NI25_RS31190	COG0564	pseudouridine synthase activity
NI25_RS31205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NI25_RS31210	COG4175	Glycine betaine
NI25_RS31210	COG0517	IMP dehydrogenase activity
NI25_RS31215	COG4176	ABC-type proline glycine betaine transport system permease component
NI25_RS31240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NI25_RS31250	COG0174	glutamine synthetase
NI25_RS31255	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS31300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NI25_RS31305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NI25_RS31310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NI25_RS31315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NI25_RS31320	COG5002	protein histidine kinase activity
NI25_RS31325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NI25_RS31330	COG0072	phenylalanine-tRNA ligase activity
NI25_RS31330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NI25_RS31350	COG1649	PFAM Uncharacterised BCR, COG1649
NI25_RS31360	COG0697	spore germination
NI25_RS31390	COG3903	Transcriptional regulator
NI25_RS31390	COG2197	response regulator
NI25_RS31395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NI25_RS31400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NI25_RS31405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NI25_RS31410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NI25_RS31415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NI25_RS31420	COG1438	arginine binding
NI25_RS31450	COG0165	Argininosuccinate lyase
NI25_RS31465	COG0477	Major facilitator Superfamily
NI25_RS31470	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS31470	COG0204	Acyl-transferase
NI25_RS31475	COG0584	glycerophosphoryl diester phosphodiesterase
NI25_RS31505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NI25_RS31510	COG2011	ABC-type metal ion transport system permease component
NI25_RS31515	COG1464	Belongs to the NlpA lipoprotein family
NI25_RS31530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NI25_RS31535	COG1648	precorrin-2 dehydrogenase activity
NI25_RS31535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NI25_RS31590	COG0512	Glutamine amidotransferase of anthranilate synthase
NI25_RS31590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NI25_RS31645	COG1175	transmembrane transport
NI25_RS31650	COG0395	ABC-type sugar transport system, permease component
NI25_RS31675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NI25_RS31690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NI25_RS31710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NI25_RS31715	COG1560	Kdo2-lipid A biosynthetic process
NI25_RS31720	COG0438	transferase activity, transferring glycosyl groups
NI25_RS31730	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NI25_RS31735	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NI25_RS31740	COG0217	transcriptional regulatory protein
NI25_RS31745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NI25_RS31750	COG0632	four-way junction helicase activity
NI25_RS31755	COG2255	four-way junction helicase activity
NI25_RS31765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NI25_RS31770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NI25_RS31775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NI25_RS31780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NI25_RS31785	COG1196	nuclear chromosome segregation
NI25_RS31790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NI25_RS31800	COG0124	histidyl-tRNA synthetase
NI25_RS31815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NI25_RS31835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NI25_RS31840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NI25_RS31850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NI25_RS31860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NI25_RS31865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NI25_RS31870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NI25_RS31880	COG0006	proline dipeptidase activity
NI25_RS31885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NI25_RS31890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NI25_RS31900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NI25_RS31905	COG0540	Belongs to the ATCase OTCase family
NI25_RS31910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NI25_RS31920	COG0505	Belongs to the CarA family
NI25_RS31925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NI25_RS31930	COG0167	dihydroorotate dehydrogenase activity
NI25_RS31935	COG0284	orotidine-5'-phosphate decarboxylase activity
NI25_RS31945	COG0194	GDP metabolic process
NI25_RS31950	COG1758	RNA polymerase activity
NI25_RS31960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NI25_RS31975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NI25_RS31995	COG0515	serine threonine protein kinase
NI25_RS32010	COG1653	transport
NI25_RS32015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NI25_RS32020	COG2390	Transcriptional regulator
NI25_RS32040	COG0531	amino acid
NI25_RS32060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NI25_RS32085	COG2233	PERMEase
NI25_RS32095	COG2223	nitrite transmembrane transporter activity
NI25_RS32100	COG1846	Transcriptional regulator
NI25_RS32125	COG3201	nicotinamide mononucleotide transporter
NI25_RS32130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NI25_RS32130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NI25_RS32135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NI25_RS32140	COG0140	phosphoribosyl-ATP diphosphatase activity
NI25_RS32145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NI25_RS32190	COG1960	acyl-CoA dehydrogenase activity
NI25_RS32215	COG0463	Glycosyl transferase, family 2
NI25_RS32230	COG2270	Major facilitator Superfamily
NI25_RS32240	COG2364	Membrane
NI25_RS32270	COG4336	lyase activity
NI25_RS32275	COG2814	Major facilitator Superfamily
NI25_RS32305	COG0326	Molecular chaperone. Has ATPase activity
NI25_RS32325	COG2018	Roadblock/LC7 domain
NI25_RS32340	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NI25_RS32355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NI25_RS32365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NI25_RS32395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NI25_RS32415	COG1716	ATPase activity
NI25_RS32435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NI25_RS32445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NI25_RS32445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NI25_RS32465	COG0725	ABC transporter, periplasmic molybdate-binding protein
NI25_RS32480	COG1609	Transcriptional regulator
NI25_RS32510	COG2197	response regulator
NI25_RS32515	COG4585	Histidine kinase
NI25_RS32525	COG0577	efflux transmembrane transporter activity
NI25_RS32525	COG1136	(ABC) transporter
NI25_RS32565	COG0697	spore germination
NI25_RS32580	COG0723	plastoquinol--plastocyanin reductase activity
NI25_RS32620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NI25_RS32635	COG2318	DinB family
NI25_RS32655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NI25_RS32660	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS32680	COG2197	response regulator
NI25_RS32685	COG4585	Histidine kinase
NI25_RS32690	COG2409	Drug exporters of the RND superfamily
NI25_RS32710	COG1968	undecaprenyl-diphosphatase activity
NI25_RS32725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NI25_RS32760	COG0110	maltose O-acetyltransferase activity
NI25_RS32780	COG0640	Transcriptional regulator
NI25_RS32785	COG1832	CoA-binding protein
NI25_RS32795	COG1739	Uncharacterized protein family UPF0029
NI25_RS32830	COG0420	3'-5' exonuclease activity
NI25_RS32835	COG0419	ATPase involved in DNA repair
NI25_RS32840	COG1522	sequence-specific DNA binding
NI25_RS32855	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS32870	COG0626	cystathionine gamma-synthase activity
NI25_RS32895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NI25_RS32935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI25_RS32935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NI25_RS32945	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NI25_RS32950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NI25_RS33080	COG1595	DNA-templated transcription, initiation
NI25_RS33085	COG2188	Transcriptional regulator
NI25_RS33090	COG1940	carbohydrate kinase activity
NI25_RS33095	COG2197	response regulator
NI25_RS33100	COG4585	Histidine kinase
NI25_RS33125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NI25_RS33145	COG0456	acetyltransferase
NI25_RS33165	COG2226	methyltransferase
NI25_RS33170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NI25_RS33175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NI25_RS33180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NI25_RS33210	COG0831	urea catabolic process
NI25_RS33215	COG0832	Belongs to the urease beta subunit family
NI25_RS33220	COG0804	urea catabolic process
NI25_RS33225	COG0830	nickel cation binding
NI25_RS33230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NI25_RS33235	COG0829	nickel cation binding
NI25_RS33250	COG0204	Acyl-transferase
NI25_RS33275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NI25_RS33280	COG1834	amidinotransferase
NI25_RS33285	COG1522	sequence-specific DNA binding
NI25_RS33300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NI25_RS33305	COG3275	phosphorelay sensor kinase activity
NI25_RS33315	COG0205	6-phosphofructokinase activity
NI25_RS33320	COG3442	glutamine amidotransferase
NI25_RS33325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NI25_RS33330	COG0242	peptide deformylase activity
NI25_RS33340	COG1960	acyl-CoA dehydrogenase activity
NI25_RS33350	COG2124	cytochrome p450
NI25_RS33355	COG3424	synthase
NI25_RS33365	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS33375	COG1793	dna ligase
NI25_RS33395	COG1960	acyl-CoA dehydrogenase activity
NI25_RS33400	COG1960	acyl-CoA dehydrogenase activity
NI25_RS33470	COG1012	belongs to the aldehyde dehydrogenase family
NI25_RS33485	COG1846	Transcriptional regulator
NI25_RS33485	COG1940	carbohydrate kinase activity
NI25_RS33490	COG1070	Carbohydrate kinase
NI25_RS33495	COG2115	Belongs to the xylose isomerase family
NI25_RS33505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NI25_RS33550	COG2018	Roadblock/LC7 domain
NI25_RS33560	COG1946	Acyl-CoA thioesterase
NI25_RS33575	COG0254	rRNA binding
NI25_RS33585	COG1132	(ABC) transporter
NI25_RS33590	COG1132	(ABC) transporter
NI25_RS33605	COG1132	(ABC) transporter
NI25_RS33615	COG2072	flavoprotein involved in K transport
NI25_RS33620	COG0432	Pfam Uncharacterised protein family UPF0047
NI25_RS33630	COG1063	alcohol dehydrogenase
NI25_RS33665	COG3290	protein histidine kinase activity
NI25_RS33670	COG4565	transcriptional regulatory protein
NI25_RS33680	COG2080	2 iron, 2 sulfur cluster binding
NI25_RS33685	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NI25_RS33690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NI25_RS33700	COG3387	PFAM Glycoside hydrolase 15-related
NI25_RS33715	COG4221	oxidoreductase activity
NI25_RS33750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NI25_RS33765	COG2706	6-phosphogluconolactonase activity
NI25_RS33775	COG2971	BadF BadG BcrA BcrD
NI25_RS33780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NI25_RS33790	COG1960	acyl-CoA dehydrogenase activity
NI25_RS33805	COG1902	pentaerythritol trinitrate reductase activity
NI25_RS33810	COG0640	Transcriptional regulator
NI25_RS33820	COG1309	transcriptional regulator
NI25_RS33830	COG0671	phosphoesterase, PA-phosphatase related
NI25_RS33870	COG0584	glycerophosphoryl diester phosphodiesterase
NI25_RS33895	COG0204	Acyl-transferase
NI25_RS33915	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NI25_RS33945	COG1660	Displays ATPase and GTPase activities
NI25_RS33955	COG0445	tRNA wobble uridine modification
NI25_RS33960	COG4585	Histidine kinase
NI25_RS33965	COG2197	response regulator
NI25_RS33985	COG0738	Major facilitator superfamily
NI25_RS33990	COG1609	Transcriptional regulator
NI25_RS34000	COG1175	transmembrane transport
NI25_RS34005	COG0395	ABC-type sugar transport system, permease component
NI25_RS34010	COG3250	beta-galactosidase activity
NI25_RS34020	COG2723	6-phospho-beta-galactosidase activity
NI25_RS34025	COG0395	ABC-type sugar transport system, permease component
NI25_RS34030	COG1175	transmembrane transport
NI25_RS34040	COG1501	Belongs to the glycosyl hydrolase 31 family
NI25_RS34055	COG0783	Belongs to the Dps family
NI25_RS34060	COG0673	inositol 2-dehydrogenase activity
NI25_RS34080	COG2608	mercury ion transmembrane transporter activity
NI25_RS34095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NI25_RS34100	COG0191	fructose-bisphosphate aldolase activity
NI25_RS34105	COG2813	Specifically methylates the guanine in position
NI25_RS34115	COG1940	carbohydrate kinase activity
NI25_RS34150	COG1136	(ABC) transporter
NI25_RS34180	COG1349	DNA-binding transcription factor activity
NI25_RS34210	COG0463	Glycosyl transferase, family 2
NI25_RS34215	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NI25_RS34235	COG3345	alpha-galactosidase
NI25_RS34265	COG1609	Transcriptional regulator
NI25_RS34275	COG1175	transmembrane transport
NI25_RS34285	COG1472	Belongs to the glycosyl hydrolase 3 family
NI25_RS34300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NI25_RS34310	COG0137	argininosuccinate synthase activity
NI25_RS34330	COG0444	Belongs to the ABC transporter superfamily
NI25_RS34335	COG0601	transmembrane transport
NI25_RS34340	COG4166	transmembrane transport
NI25_RS34350	COG3458	cephalosporin-C deacetylase activity
NI25_RS34370	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NI25_RS34385	COG1846	Transcriptional regulator
NI25_RS34390	COG0640	Transcriptional regulator
NI25_RS34395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NI25_RS34400	COG1993	acr, cog1993
NI25_RS34405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NI25_RS34410	COG1968	undecaprenyl-diphosphatase activity
NI25_RS34420	COG2066	Belongs to the glutaminase family
NI25_RS34430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NI25_RS34445	COG2226	methyltransferase
NI25_RS34450	COG2188	Transcriptional regulator
NI25_RS34455	COG3458	cephalosporin-C deacetylase activity
NI25_RS34470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NI25_RS34480	COG2890	protein-(glutamine-N5) methyltransferase activity
NI25_RS34500	COG1902	pentaerythritol trinitrate reductase activity
NI25_RS34500	COG0446	pyridine nucleotide-disulphide oxidoreductase
NI25_RS34530	COG1461	Dihydroxyacetone kinase
NI25_RS34535	COG2376	Dihydroxyacetone kinase
NI25_RS34540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NI25_RS34555	COG1609	Transcriptional regulator
NI25_RS34565	COG2814	Major facilitator Superfamily
NI25_RS34630	COG0745	RESPONSE REGULATOR receiver
NI25_RS34635	COG2205	protein histidine kinase activity
NI25_RS34645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NI25_RS34655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NI25_RS34685	COG0515	serine threonine protein kinase
NI25_RS34700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NI25_RS34705	COG0318	PFAM AMP-dependent synthetase and ligase
NI25_RS34715	COG0589	response to stress
NI25_RS34750	COG0673	inositol 2-dehydrogenase activity
NI25_RS34790	COG0431	NADPH-dependent FMN reductase
NI25_RS34800	COG0667	Aldo Keto reductase
NI25_RS34805	COG0346	lactoylglutathione lyase activity
NI25_RS34810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI25_RS34820	COG0583	DNA-binding transcription factor activity
NI25_RS34825	COG0667	Aldo Keto reductase
NI25_RS34860	COG1191	sigma factor activity
NI25_RS34865	COG1396	sequence-specific DNA binding
NI25_RS34870	COG0740	serine-type endopeptidase activity
NI25_RS34875	COG0740	serine-type endopeptidase activity
NI25_RS34890	COG0328	RNA-DNA hybrid ribonuclease activity
NI25_RS34900	COG0667	Aldo Keto reductase
NI25_RS34920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS34925	COG0515	serine threonine protein kinase
NI25_RS34930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NI25_RS34940	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NI25_RS34940	COG1672	PFAM Archaeal ATPase
NI25_RS34970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NI25_RS35010	COG0477	Major facilitator Superfamily
NI25_RS35020	COG1982	Orn Lys Arg decarboxylase major
NI25_RS35055	COG1252	NADH dehydrogenase
NI25_RS35070	COG2172	sigma factor antagonist activity
NI25_RS35075	COG1366	Belongs to the anti-sigma-factor antagonist family
NI25_RS35080	COG1366	Belongs to the anti-sigma-factor antagonist family
NI25_RS35095	COG2205	protein histidine kinase activity
NI25_RS35095	COG5002	protein histidine kinase activity
NI25_RS35095	COG0784	Response regulator, receiver
NI25_RS35125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NI25_RS35130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NI25_RS35145	COG0366	Alpha amylase catalytic
NI25_RS35185	COG0181	hydroxymethylbilane synthase activity
NI25_RS35195	COG3285	dna ligase
NI25_RS35195	COG1793	dna ligase
NI25_RS35220	COG2208	phosphoserine phosphatase activity
NI25_RS35230	COG0656	L-ascorbic acid biosynthetic process
NI25_RS35245	COG0009	L-threonylcarbamoyladenylate synthase
NI25_RS35285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NI25_RS35300	COG1088	dTDP-glucose 4,6-dehydratase activity
NI25_RS35320	COG0243	molybdopterin cofactor binding
NI25_RS35325	COG0456	acetyltransferase
NI25_RS35360	COG2124	cytochrome p450
NI25_RS35370	COG0475	glutathione-regulated potassium exporter activity
NI25_RS35400	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NI25_RS35465	COG1120	ATPase activity
NI25_RS35490	COG0110	maltose O-acetyltransferase activity
NI25_RS35510	COG0395	ABC-type sugar transport system, permease component
NI25_RS35515	COG4209	transmembrane transport
NI25_RS35525	COG0028	Belongs to the TPP enzyme family
NI25_RS35530	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS35555	COG2814	Major facilitator Superfamily
NI25_RS35565	COG1959	2 iron, 2 sulfur cluster binding
NI25_RS35585	COG5640	endopeptidase activity
NI25_RS35590	COG0583	DNA-binding transcription factor activity
NI25_RS35600	COG2814	Major facilitator Superfamily
NI25_RS35615	COG0583	DNA-binding transcription factor activity
NI25_RS35625	COG3340	Belongs to the peptidase S51 family
NI25_RS35640	COG2124	cytochrome p450
NI25_RS35645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NI25_RS35695	COG1335	isochorismatase
NI25_RS35710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI25_RS35720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NI25_RS35725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NI25_RS35730	COG1119	ATPase activity
NI25_RS35740	COG5640	endopeptidase activity
NI25_RS35795	COG3396	Phenylacetate-CoA oxygenase
NI25_RS35800	COG3460	Phenylacetate-CoA oxygenase
NI25_RS35805	COG3396	Phenylacetate-CoA oxygenase
NI25_RS35810	COG2151	metal-sulfur cluster biosynthetic enzyme
NI25_RS35815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NI25_RS35865	COG1953	Uracil, thiamine, allantoin
NI25_RS35880	COG1175	transmembrane transport
NI25_RS35885	COG0395	ABC-type sugar transport system, permease component
NI25_RS35895	COG2175	clavaminate synthase activity
NI25_RS35920	COG4977	sequence-specific DNA binding
NI25_RS35925	COG2755	lipolytic protein G-D-S-L family
NI25_RS35935	COG0326	Molecular chaperone. Has ATPase activity
NI25_RS35945	COG3226	Transcriptional regulator
NI25_RS35960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NI25_RS36005	COG2409	Drug exporters of the RND superfamily
NI25_RS36010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NI25_RS36020	COG0517	IMP dehydrogenase activity
NI25_RS36020	COG0516	GMP reductase activity
NI25_RS36055	COG3119	arylsulfatase activity
NI25_RS36060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NI25_RS36065	COG0584	glycerophosphoryl diester phosphodiesterase
NI25_RS36100	COG0395	ABC-type sugar transport system, permease component
NI25_RS36115	COG1051	belongs to the nudix hydrolase family
NI25_RS36120	COG0584	glycerophosphoryl diester phosphodiesterase
NI25_RS36130	COG1366	Belongs to the anti-sigma-factor antagonist family
NI25_RS36175	COG5297	Belongs to the glycosyl hydrolase family 6
NI25_RS36175	COG3250	beta-galactosidase activity
NI25_RS36220	COG0667	Aldo Keto reductase
NI25_RS36225	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NI25_RS36230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NI25_RS36240	COG1737	Transcriptional regulator
NI25_RS36245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NI25_RS36250	COG0154	amidase activity
NI25_RS36255	COG1309	transcriptional regulator
NI25_RS36260	COG3291	Pkd domain containing protein
NI25_RS36260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NI25_RS36310	COG2353	YceI-like domain
NI25_RS36335	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NI25_RS36340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NI25_RS36355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI25_RS36385	COG1028	Short-chain dehydrogenase reductase Sdr
NI25_RS36420	COG0302	gtp cyclohydrolase
NI25_RS36435	COG4948	Mandelate Racemase Muconate Lactonizing
NI25_RS36445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NI25_RS36490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NI25_RS36510	COG0488	(ABC) transporter
NI25_RS36525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NI25_RS36540	COG1470	cell adhesion involved in biofilm formation
NI25_RS36540	COG0366	Alpha amylase catalytic
NI25_RS36545	COG1609	Transcriptional regulator
NI25_RS36555	COG0154	amidase activity
NI25_RS36625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NI25_RS36650	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NI25_RS36665	COG0583	DNA-binding transcription factor activity
NI25_RS36670	COG1595	DNA-templated transcription, initiation
NI25_RS36680	COG0789	Transcriptional regulator
NI25_RS36685	COG4221	oxidoreductase activity
NI25_RS36690	COG0542	response to heat
NI25_RS36740	COG0577	efflux transmembrane transporter activity
NI25_RS36775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NI25_RS36795	COG2226	methyltransferase
NI25_RS36800	COG2226	methyltransferase
NI25_RS36810	COG2208	phosphoserine phosphatase activity
NI25_RS36810	COG2770	Histidine kinase
NI25_RS36820	COG1609	Transcriptional regulator
NI25_RS36840	COG1175	transmembrane transport
NI25_RS36845	COG0395	ABC-type sugar transport system, permease component
NI25_RS36865	COG0644	oxidoreductase
NI25_RS36870	COG3655	Transcriptional regulator
NI25_RS36880	COG0477	Major facilitator Superfamily
NI25_RS36895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NI25_RS36965	COG2318	DinB family
NI25_RS36980	COG0702	epimerase
NI25_RS37010	COG3328	transposase activity
NI25_RS37015	COG1309	transcriptional regulator