locus-tag	class	description
CAC01_RS00050	COG1196	nuclear chromosome segregation
CAC01_RS00095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAC01_RS00105	COG0656	L-ascorbic acid biosynthetic process
CAC01_RS00120	COG1404	Belongs to the peptidase S8 family
CAC01_RS00135	COG3340	Belongs to the peptidase S51 family
CAC01_RS00140	COG1414	Transcriptional regulator
CAC01_RS00150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CAC01_RS00155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAC01_RS00180	COG2850	peptidyl-arginine hydroxylation
CAC01_RS00195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAC01_RS00200	COG3959	Transketolase, thiamine diphosphate binding domain
CAC01_RS00220	COG1131	(ABC) transporter
CAC01_RS00225	COG1725	Transcriptional regulator
CAC01_RS00265	COG0142	geranyltranstransferase activity
CAC01_RS00275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CAC01_RS00305	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAC01_RS00305	COG1136	(ABC) transporter
CAC01_RS00320	COG1136	(ABC) transporter
CAC01_RS00320	COG0577	efflux transmembrane transporter activity
CAC01_RS00325	COG2814	Major facilitator Superfamily
CAC01_RS00330	COG0656	L-ascorbic acid biosynthetic process
CAC01_RS00340	COG1793	dna ligase
CAC01_RS00395	COG0477	Major facilitator Superfamily
CAC01_RS00400	COG1077	Cell shape determining protein MreB Mrl
CAC01_RS00410	COG2723	6-phospho-beta-galactosidase activity
CAC01_RS00415	COG0395	ABC-type sugar transport system, permease component
CAC01_RS00420	COG1175	transmembrane transport
CAC01_RS00425	COG2182	Extracellular solute-binding protein
CAC01_RS00430	COG1940	carbohydrate kinase activity
CAC01_RS00445	COG1252	NADH dehydrogenase
CAC01_RS00450	COG3537	Alpha-1,2-mannosidase
CAC01_RS00495	COG2376	Dihydroxyacetone kinase
CAC01_RS00500	COG1461	Dihydroxyacetone kinase
CAC01_RS00590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAC01_RS00595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAC01_RS00600	COG2080	2 iron, 2 sulfur cluster binding
CAC01_RS00610	COG2304	oxidoreductase activity
CAC01_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS00660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CAC01_RS00665	COG1215	transferase activity, transferring glycosyl groups
CAC01_RS00695	COG1349	DNA-binding transcription factor activity
CAC01_RS00720	COG0738	Major facilitator superfamily
CAC01_RS00725	COG0445	tRNA wobble uridine modification
CAC01_RS00770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CAC01_RS00785	COG0204	Acyl-transferase
CAC01_RS00805	COG0584	glycerophosphoryl diester phosphodiesterase
CAC01_RS00820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAC01_RS00860	COG0671	phosphoesterase, PA-phosphatase related
CAC01_RS00885	COG2233	PERMEase
CAC01_RS00890	COG0640	Transcriptional regulator
CAC01_RS00895	COG1902	pentaerythritol trinitrate reductase activity
CAC01_RS00900	COG2040	homocysteine
CAC01_RS00905	COG2814	Major facilitator Superfamily
CAC01_RS00910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAC01_RS00915	COG2971	BadF BadG BcrA BcrD
CAC01_RS00925	COG2706	6-phosphogluconolactonase activity
CAC01_RS00935	COG1309	transcriptional regulator
CAC01_RS00955	COG0395	ABC-type sugar transport system, permease component
CAC01_RS00965	COG5183	chlorophyll binding
CAC01_RS00965	COG2133	pyrroloquinoline quinone binding
CAC01_RS00970	COG1609	Transcriptional regulator
CAC01_RS00975	COG1879	ABC-type sugar transport system periplasmic component
CAC01_RS00980	COG1129	ABC transporter
CAC01_RS00985	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS00990	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS00995	COG1309	transcriptional regulator
CAC01_RS01000	COG1024	Enoyl-CoA hydratase
CAC01_RS01015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAC01_RS01050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CAC01_RS01060	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS01065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAC01_RS01100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAC01_RS01125	COG0395	ABC-type sugar transport system, permease component
CAC01_RS01130	COG3507	Belongs to the glycosyl hydrolase 43 family
CAC01_RS01140	COG1136	(ABC) transporter
CAC01_RS01145	COG0577	efflux transmembrane transporter activity
CAC01_RS01155	COG1309	transcriptional regulator
CAC01_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS01220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAC01_RS01270	COG2222	sugar isomerase
CAC01_RS01280	COG1486	melibiose metabolic process
CAC01_RS01290	COG0129	dihydroxy-acid dehydratase activity
CAC01_RS01310	COG1349	DNA-binding transcription factor activity
CAC01_RS01325	COG1175	transmembrane transport
CAC01_RS01330	COG0395	ABC-type sugar transport system, permease component
CAC01_RS01335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAC01_RS01365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CAC01_RS01370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAC01_RS01375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAC01_RS01390	COG1121	(ABC) transporter
CAC01_RS01395	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAC01_RS01400	COG1169	isochorismate synthase
CAC01_RS01405	COG1132	(ABC) transporter
CAC01_RS01410	COG1132	(ABC) transporter
CAC01_RS01410	COG2375	cellular response to nickel ion
CAC01_RS01425	COG2124	cytochrome p450
CAC01_RS01440	COG3433	isochorismatase activity
CAC01_RS01440	COG2226	methyltransferase
CAC01_RS01440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAC01_RS01445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAC01_RS01450	COG1021	2,3-dihydroxybenzoate-AMP ligase
CAC01_RS01455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAC01_RS01460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS01465	COG0601	transmembrane transport
CAC01_RS01480	COG0523	cobalamin synthesis protein
CAC01_RS01490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAC01_RS01500	COG0254	rRNA binding
CAC01_RS01535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CAC01_RS01550	COG0655	NAD(P)H dehydrogenase (quinone) activity
CAC01_RS01630	COG0667	Aldo Keto reductase
CAC01_RS01640	COG3268	Saccharopine dehydrogenase
CAC01_RS01645	COG0432	Pfam Uncharacterised protein family UPF0047
CAC01_RS01650	COG2072	flavoprotein involved in K transport
CAC01_RS01655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAC01_RS01660	COG1132	(ABC) transporter
CAC01_RS01700	COG1946	Acyl-CoA thioesterase
CAC01_RS01710	COG2018	Roadblock/LC7 domain
CAC01_RS01790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAC01_RS01810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAC01_RS01815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAC01_RS01850	COG1125	glycine betaine transport
CAC01_RS01850	COG0517	IMP dehydrogenase activity
CAC01_RS01865	COG1174	glycine betaine transport
CAC01_RS01890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAC01_RS01905	COG1024	Enoyl-CoA hydratase
CAC01_RS01910	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS01920	COG1609	Transcriptional regulator
CAC01_RS01930	COG4124	Belongs to the glycosyl hydrolase 26 family
CAC01_RS01950	COG1175	transmembrane transport
CAC01_RS01955	COG3833	ABC-type maltose transport systems, permease component
CAC01_RS01960	COG3250	beta-galactosidase activity
CAC01_RS02000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CAC01_RS02010	COG2188	Transcriptional regulator
CAC01_RS02035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAC01_RS02045	COG2382	esterase
CAC01_RS02050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAC01_RS02055	COG1535	isochorismatase
CAC01_RS02055	COG3433	isochorismatase activity
CAC01_RS02065	COG1021	2,3-dihydroxybenzoate-AMP ligase
CAC01_RS02070	COG1169	isochorismate synthase
CAC01_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS02080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CAC01_RS02085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS02090	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS02095	COG1120	ATPase activity
CAC01_RS02110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAC01_RS02120	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CAC01_RS02125	COG2079	MmgE PrpD family protein
CAC01_RS02130	COG3800	Transcriptional regulator
CAC01_RS02130	COG1396	sequence-specific DNA binding
CAC01_RS02140	COG4106	trans-aconitate 2-methyltransferase activity
CAC01_RS02145	COG2226	methyltransferase
CAC01_RS02150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CAC01_RS02160	COG1309	transcriptional regulator
CAC01_RS02195	COG1802	Transcriptional regulator
CAC01_RS02200	COG0402	S-adenosylhomocysteine deaminase activity
CAC01_RS02205	COG4608	Belongs to the ABC transporter superfamily
CAC01_RS02210	COG0444	Belongs to the ABC transporter superfamily
CAC01_RS02215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS02230	COG0477	Major facilitator Superfamily
CAC01_RS02240	COG0488	(ABC) transporter
CAC01_RS02245	COG1309	transcriptional regulator
CAC01_RS02260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAC01_RS02295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAC01_RS02315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAC01_RS02320	COG0121	glutamine amidotransferase
CAC01_RS02325	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CAC01_RS02340	COG2182	Extracellular solute-binding protein
CAC01_RS02345	COG3360	Dodecin
CAC01_RS02360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS02380	COG0596	Alpha beta hydrolase
CAC01_RS02395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAC01_RS02400	COG1053	succinate dehydrogenase
CAC01_RS02410	COG0583	DNA-binding transcription factor activity
CAC01_RS02450	COG0726	polysaccharide deacetylase
CAC01_RS02475	COG3275	phosphorelay sensor kinase activity
CAC01_RS02500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAC01_RS02515	COG4948	Mandelate Racemase Muconate Lactonizing
CAC01_RS02520	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS02525	COG1129	ABC transporter
CAC01_RS02530	COG1879	ABC-type sugar transport system periplasmic component
CAC01_RS02540	COG0366	Alpha amylase catalytic
CAC01_RS02545	COG3833	ABC-type maltose transport systems, permease component
CAC01_RS02550	COG1175	transmembrane transport
CAC01_RS02555	COG2182	Extracellular solute-binding protein
CAC01_RS02560	COG1609	Transcriptional regulator
CAC01_RS02575	COG2186	Transcriptional regulator
CAC01_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS02595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CAC01_RS02600	COG0297	glycogen (starch) synthase activity
CAC01_RS02615	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CAC01_RS02625	COG1132	(ABC) transporter
CAC01_RS02635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAC01_RS02640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAC01_RS02645	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CAC01_RS02665	COG0110	maltose O-acetyltransferase activity
CAC01_RS02675	COG0300	oxidoreductase activity
CAC01_RS02680	COG0789	Transcriptional regulator
CAC01_RS02695	COG0489	protein tyrosine kinase activity
CAC01_RS02700	COG0297	glycogen (starch) synthase activity
CAC01_RS02720	COG1132	(ABC) transporter
CAC01_RS02735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CAC01_RS02740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS02745	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS02750	COG1120	ATPase activity
CAC01_RS02775	COG2124	cytochrome p450
CAC01_RS02780	COG0242	peptide deformylase activity
CAC01_RS02815	COG2223	nitrite transmembrane transporter activity
CAC01_RS02840	COG0745	RESPONSE REGULATOR receiver
CAC01_RS02845	COG2205	protein histidine kinase activity
CAC01_RS02855	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS02875	COG0395	ABC-type sugar transport system, permease component
CAC01_RS02930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAC01_RS02965	COG0693	protein deglycase activity
CAC01_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS02995	COG0583	DNA-binding transcription factor activity
CAC01_RS03015	COG3647	Membrane
CAC01_RS03075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAC01_RS03080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CAC01_RS03085	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CAC01_RS03090	COG0352	thiamine-phosphate diphosphorylase activity
CAC01_RS03100	COG1295	ribonuclease BN
CAC01_RS03150	COG1131	(ABC) transporter
CAC01_RS03165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CAC01_RS03165	COG2070	2-Nitropropane dioxygenase
CAC01_RS03170	COG3321	synthase
CAC01_RS03170	COG0604	alcohol dehydrogenase
CAC01_RS03185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAC01_RS03195	COG1397	ADP-ribosylglycohydrolase
CAC01_RS03200	COG2188	Transcriptional regulator
CAC01_RS03205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CAC01_RS03210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAC01_RS03235	COG1733	regulation of RNA biosynthetic process
CAC01_RS03265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAC01_RS03275	COG4166	transmembrane transport
CAC01_RS03290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS03295	COG0601	transmembrane transport
CAC01_RS03300	COG1940	carbohydrate kinase activity
CAC01_RS03305	COG0235	Class ii aldolase
CAC01_RS03310	COG3395	kinase activity
CAC01_RS03325	COG1349	DNA-binding transcription factor activity
CAC01_RS03330	COG5492	domain, Protein
CAC01_RS03345	COG1175	transmembrane transport
CAC01_RS03350	COG0395	ABC-type sugar transport system, permease component
CAC01_RS03355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAC01_RS03375	COG3959	Transketolase, thiamine diphosphate binding domain
CAC01_RS03380	COG3958	Transketolase
CAC01_RS03390	COG2267	carboxylic ester hydrolase activity
CAC01_RS03410	COG2018	Roadblock/LC7 domain
CAC01_RS03420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAC01_RS03425	COG1940	carbohydrate kinase activity
CAC01_RS03445	COG3119	arylsulfatase activity
CAC01_RS03450	COG3507	Belongs to the glycosyl hydrolase 43 family
CAC01_RS03480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAC01_RS03495	COG1733	regulation of RNA biosynthetic process
CAC01_RS03505	COG2755	lipolytic protein G-D-S-L family
CAC01_RS03535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAC01_RS03550	COG1657	PFAM Prenyltransferase squalene oxidase
CAC01_RS03560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CAC01_RS03570	COG1562	ergosterol biosynthetic process
CAC01_RS03575	COG1388	LysM domain
CAC01_RS03575	COG1134	teichoic acid transport
CAC01_RS03615	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CAC01_RS03625	COG1902	pentaerythritol trinitrate reductase activity
CAC01_RS03630	COG1846	Transcriptional regulator
CAC01_RS03645	COG2183	response to ionizing radiation
CAC01_RS03670	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAC01_RS03670	COG1024	Enoyl-CoA hydratase
CAC01_RS03675	COG0183	Belongs to the thiolase family
CAC01_RS03680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAC01_RS03685	COG1683	Conserved Protein
CAC01_RS03690	COG0494	nUDIX hydrolase
CAC01_RS03705	COG3268	Saccharopine dehydrogenase
CAC01_RS03715	COG1515	deoxyribonuclease V activity
CAC01_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS03775	COG1793	dna ligase
CAC01_RS03825	COG1672	PFAM Archaeal ATPase
CAC01_RS03825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAC01_RS03850	COG3548	integral membrane protein
CAC01_RS03855	COG0488	(ABC) transporter
CAC01_RS03915	COG0673	inositol 2-dehydrogenase activity
CAC01_RS03925	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS03930	COG1129	ABC transporter
CAC01_RS03935	COG1940	carbohydrate kinase activity
CAC01_RS03940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAC01_RS03955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAC01_RS03960	COG0738	Major facilitator superfamily
CAC01_RS03970	COG0583	DNA-binding transcription factor activity
CAC01_RS03995	COG2226	methyltransferase
CAC01_RS04000	COG2154	pterin-4-alpha-carbinolamine dehydratase
CAC01_RS04005	COG3469	chitinase activity
CAC01_RS04035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CAC01_RS04065	COG0488	(ABC) transporter
CAC01_RS04075	COG2226	methyltransferase
CAC01_RS04080	COG3959	Transketolase, thiamine diphosphate binding domain
CAC01_RS04115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAC01_RS04120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CAC01_RS04130	COG1619	proteins homologs of microcin C7 resistance protein MccF
CAC01_RS04150	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAC01_RS04155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAC01_RS04160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAC01_RS04195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CAC01_RS04195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CAC01_RS04200	COG2301	Belongs to the HpcH HpaI aldolase family
CAC01_RS04205	COG0688	phosphatidylethanolamine metabolic process
CAC01_RS04215	COG1929	Belongs to the glycerate kinase type-1 family
CAC01_RS04220	COG0494	nUDIX hydrolase
CAC01_RS04235	COG1309	transcriptional regulator
CAC01_RS04245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAC01_RS04255	COG3250	beta-galactosidase activity
CAC01_RS04265	COG1175	transmembrane transport
CAC01_RS04270	COG0395	ABC-type sugar transport system, permease component
CAC01_RS04275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAC01_RS04280	COG1063	alcohol dehydrogenase
CAC01_RS04285	COG0156	8-amino-7-oxononanoate synthase activity
CAC01_RS04290	COG0583	DNA-binding transcription factor activity
CAC01_RS04295	COG0563	adenylate kinase activity
CAC01_RS04305	COG0483	inositol monophosphate 1-phosphatase activity
CAC01_RS04310	COG0095	Lipoate-protein ligase
CAC01_RS04330	COG1953	Uracil, thiamine, allantoin
CAC01_RS04340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAC01_RS04345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAC01_RS04390	COG0405	Gamma-glutamyltransferase
CAC01_RS04400	COG0542	response to heat
CAC01_RS04410	COG0765	amino acid transport
CAC01_RS04415	COG0765	amino acid transport
CAC01_RS04420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAC01_RS04425	COG1126	abc transporter atp-binding protein
CAC01_RS04450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CAC01_RS04455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAC01_RS04490	COG0667	Aldo Keto reductase
CAC01_RS04505	COG1309	transcriptional regulator
CAC01_RS04515	COG1309	transcriptional regulator
CAC01_RS04540	COG0671	phosphoesterase, PA-phosphatase related
CAC01_RS04550	COG1597	lipid kinase activity
CAC01_RS04565	COG3511	phospholipase C
CAC01_RS04580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAC01_RS04585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAC01_RS04590	COG3835	regulator
CAC01_RS04595	COG0549	Belongs to the carbamate kinase family
CAC01_RS04605	COG0402	S-adenosylhomocysteine deaminase activity
CAC01_RS04615	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CAC01_RS04620	COG0154	amidase activity
CAC01_RS04625	COG3250	beta-galactosidase activity
CAC01_RS04635	COG1175	transmembrane transport
CAC01_RS04660	COG0395	ABC-type sugar transport system, permease component
CAC01_RS04670	COG1132	(ABC) transporter
CAC01_RS04685	COG0583	DNA-binding transcription factor activity
CAC01_RS04690	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS04700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CAC01_RS04710	COG1940	carbohydrate kinase activity
CAC01_RS04730	COG2197	response regulator
CAC01_RS04750	COG4266	Belongs to the allantoicase family
CAC01_RS04755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAC01_RS04760	COG1414	Transcriptional regulator
CAC01_RS04785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAC01_RS04825	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS04895	COG2351	hydroxyisourate hydrolase activity
CAC01_RS04905	COG2814	Major facilitator Superfamily
CAC01_RS04910	COG0583	DNA-binding transcription factor activity
CAC01_RS04940	COG0318	PFAM AMP-dependent synthetase and ligase
CAC01_RS04945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAC01_RS04950	COG2197	response regulator
CAC01_RS04955	COG2318	DinB family
CAC01_RS04970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAC01_RS04985	COG3835	regulator
CAC01_RS04995	COG1802	Transcriptional regulator
CAC01_RS05015	COG0028	Belongs to the TPP enzyme family
CAC01_RS05045	COG1162	GTPase activity
CAC01_RS05050	COG1024	Enoyl-CoA hydratase
CAC01_RS05065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAC01_RS05075	COG1024	Enoyl-CoA hydratase
CAC01_RS05080	COG1024	Enoyl-CoA hydratase
CAC01_RS05095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAC01_RS05120	COG1984	allophanate hydrolase subunit 2
CAC01_RS05125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CAC01_RS05130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CAC01_RS05135	COG0277	FAD linked oxidase domain protein
CAC01_RS05145	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS05170	COG0175	sulfate reduction
CAC01_RS05175	COG0529	Catalyzes the synthesis of activated sulfate
CAC01_RS05195	COG1116	anion transmembrane transporter activity
CAC01_RS05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAC01_RS05215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAC01_RS05225	COG3458	cephalosporin-C deacetylase activity
CAC01_RS05420	COG3903	Transcriptional regulator
CAC01_RS05420	COG3629	intracellular signal transduction
CAC01_RS05460	COG3940	Belongs to the glycosyl hydrolase 43 family
CAC01_RS05475	COG0395	ABC-type sugar transport system, permease component
CAC01_RS05480	COG1175	transmembrane transport
CAC01_RS05505	COG1609	Transcriptional regulator
CAC01_RS05525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAC01_RS05530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAC01_RS05535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAC01_RS05550	COG1233	COG1233 Phytoene dehydrogenase and related
CAC01_RS05595	COG3220	belongs to the UPF0276 family
CAC01_RS05615	COG0477	Major facilitator Superfamily
CAC01_RS05635	COG0069	glutamate synthase activity
CAC01_RS05640	COG3253	May function as heme-dependent peroxidase
CAC01_RS05655	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAC01_RS05660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAC01_RS05680	COG0183	Belongs to the thiolase family
CAC01_RS05685	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAC01_RS05685	COG1024	Enoyl-CoA hydratase
CAC01_RS05710	COG0531	amino acid
CAC01_RS05715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAC01_RS05720	COG4214	carbohydrate transport
CAC01_RS05730	COG4213	ABC transporter substrate-binding protein
CAC01_RS05735	COG1940	carbohydrate kinase activity
CAC01_RS05745	COG1175	transmembrane transport
CAC01_RS05750	COG1653	transport
CAC01_RS05755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CAC01_RS05760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS05845	COG2205	protein histidine kinase activity
CAC01_RS05845	COG0784	Response regulator, receiver
CAC01_RS05855	COG2172	sigma factor antagonist activity
CAC01_RS05860	COG1366	Belongs to the anti-sigma-factor antagonist family
CAC01_RS05865	COG1366	Belongs to the anti-sigma-factor antagonist family
CAC01_RS05870	COG1132	(ABC) transporter
CAC01_RS05875	COG1132	(ABC) transporter
CAC01_RS05880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CAC01_RS05895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS05900	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS05905	COG1120	ATPase activity
CAC01_RS05915	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CAC01_RS05920	COG1609	Transcriptional regulator
CAC01_RS05935	COG0583	DNA-binding transcription factor activity
CAC01_RS05945	COG0745	RESPONSE REGULATOR receiver
CAC01_RS05950	COG2205	protein histidine kinase activity
CAC01_RS05970	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS06020	COG1120	ATPase activity
CAC01_RS06035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAC01_RS06040	COG2376	Dihydroxyacetone kinase
CAC01_RS06045	COG2376	Dihydroxyacetone kinase
CAC01_RS06070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAC01_RS06080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CAC01_RS06100	COG2318	DinB family
CAC01_RS06120	COG1799	cell septum assembly
CAC01_RS06125	COG1191	sigma factor activity
CAC01_RS06150	COG0501	Belongs to the peptidase M48B family
CAC01_RS06170	COG0431	NADPH-dependent FMN reductase
CAC01_RS06185	COG0583	DNA-binding transcription factor activity
CAC01_RS06205	COG1309	transcriptional regulator
CAC01_RS06215	COG0494	nUDIX hydrolase
CAC01_RS06230	COG0431	NADPH-dependent FMN reductase
CAC01_RS06240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS06245	COG4608	Belongs to the ABC transporter superfamily
CAC01_RS06250	COG0444	Belongs to the ABC transporter superfamily
CAC01_RS06255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS06260	COG0601	transmembrane transport
CAC01_RS06265	COG0747	negative chemotaxis
CAC01_RS06285	COG0546	phosphoglycolate phosphatase activity
CAC01_RS06300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAC01_RS06325	COG0714	Associated with various cellular activities
CAC01_RS06335	COG2936	dipeptidyl-peptidase activity
CAC01_RS06350	COG2226	methyltransferase
CAC01_RS06355	COG0671	phosphoesterase, PA-phosphatase related
CAC01_RS06360	COG1129	ABC transporter
CAC01_RS06365	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS06370	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS06390	COG1505	serine-type exopeptidase activity
CAC01_RS06410	COG3537	Alpha-1,2-mannosidase
CAC01_RS06420	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAC01_RS06425	COG1082	Xylose isomerase domain protein TIM barrel
CAC01_RS06430	COG1063	alcohol dehydrogenase
CAC01_RS06440	COG1175	transmembrane transport
CAC01_RS06445	COG0395	ABC-type sugar transport system, permease component
CAC01_RS06450	COG1940	carbohydrate kinase activity
CAC01_RS06465	COG4974	Belongs to the 'phage' integrase family
CAC01_RS06540	COG0582	viral genome integration into host DNA
CAC01_RS06580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAC01_RS06585	COG0531	amino acid
CAC01_RS06590	COG0569	domain protein
CAC01_RS06635	COG0756	dUTP diphosphatase activity
CAC01_RS06660	COG0745	RESPONSE REGULATOR receiver
CAC01_RS06670	COG0483	inositol monophosphate 1-phosphatase activity
CAC01_RS06675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAC01_RS06710	COG1435	thymidine kinase activity
CAC01_RS06725	COG0045	succinate-CoA ligase (ADP-forming) activity
CAC01_RS06730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAC01_RS06735	COG1802	Transcriptional regulator
CAC01_RS06750	COG0612	Peptidase, M16
CAC01_RS06775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAC01_RS06785	COG2197	response regulator
CAC01_RS06800	COG0187	DNA topoisomerase II activity
CAC01_RS06815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAC01_RS06820	COG1802	Transcriptional regulator
CAC01_RS06855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAC01_RS06885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAC01_RS06890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAC01_RS06895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAC01_RS06910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAC01_RS06930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAC01_RS06940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAC01_RS06950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAC01_RS06960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAC01_RS06985	COG3547	Transposase (IS116 IS110 IS902 family)
CAC01_RS06990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAC01_RS07000	COG2205	protein histidine kinase activity
CAC01_RS07005	COG0745	RESPONSE REGULATOR receiver
CAC01_RS07010	COG1126	abc transporter atp-binding protein
CAC01_RS07015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAC01_RS07020	COG0765	amino acid transport
CAC01_RS07025	COG0765	amino acid transport
CAC01_RS07030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAC01_RS07040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAC01_RS07045	COG2137	regulation of response to DNA damage stimulus
CAC01_RS07050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAC01_RS07065	COG0628	permease
CAC01_RS07090	COG1201	RNA secondary structure unwinding
CAC01_RS07095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAC01_RS07100	COG0783	Belongs to the Dps family
CAC01_RS07105	COG1396	sequence-specific DNA binding
CAC01_RS07110	COG1058	Belongs to the CinA family
CAC01_RS07110	COG1546	Belongs to the CinA family
CAC01_RS07120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAC01_RS07135	COG1674	ftsk spoiiie
CAC01_RS07145	COG0784	Response regulator, receiver
CAC01_RS07145	COG2205	protein histidine kinase activity
CAC01_RS07150	COG2208	phosphoserine phosphatase activity
CAC01_RS07150	COG2770	Histidine kinase
CAC01_RS07185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CAC01_RS07190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAC01_RS07195	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CAC01_RS07215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAC01_RS07220	COG0612	Peptidase, M16
CAC01_RS07225	COG1185	polyribonucleotide nucleotidyltransferase activity
CAC01_RS07230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAC01_RS07240	COG0455	bacterial-type flagellum organization
CAC01_RS07245	COG0747	negative chemotaxis
CAC01_RS07250	COG0601	transmembrane transport
CAC01_RS07255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS07265	COG4608	Belongs to the ABC transporter superfamily
CAC01_RS07275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAC01_RS07280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAC01_RS07290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAC01_RS07305	COG0779	Required for maturation of 30S ribosomal subunits
CAC01_RS07325	COG0442	prolyl-tRNA aminoacylation
CAC01_RS07330	COG0456	acetyltransferase
CAC01_RS07350	COG0750	zinc metalloprotease
CAC01_RS07355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAC01_RS07365	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS07395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAC01_RS07400	COG1177	transmembrane transport
CAC01_RS07405	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAC01_RS07410	COG3842	ATPase activity
CAC01_RS07445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAC01_RS07450	COG0584	glycerophosphoryl diester phosphodiesterase
CAC01_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS07470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAC01_RS07490	COG3842	ATPase activity
CAC01_RS07495	COG4149	molybdate abc transporter
CAC01_RS07505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CAC01_RS07515	COG0233	cytoplasmic translational termination
CAC01_RS07520	COG0528	UMP kinase activity
CAC01_RS07525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAC01_RS07530	COG0052	Belongs to the universal ribosomal protein uS2 family
CAC01_RS07535	COG4942	peptidase
CAC01_RS07545	COG1191	sigma factor activity
CAC01_RS07560	COG0792	nuclease activity
CAC01_RS07570	COG1051	belongs to the nudix hydrolase family
CAC01_RS07580	COG0681	Belongs to the peptidase S26 family
CAC01_RS07590	COG0681	Belongs to the peptidase S26 family
CAC01_RS07595	COG0335	large ribosomal subunit rRNA binding
CAC01_RS07600	COG0336	Belongs to the RNA methyltransferase TrmD family
CAC01_RS07605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAC01_RS07610	COG1837	Belongs to the UPF0109 family
CAC01_RS07615	COG0228	four-way junction DNA binding
CAC01_RS07630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAC01_RS07640	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAC01_RS07670	COG1196	nuclear chromosome segregation
CAC01_RS07680	COG1254	Belongs to the acylphosphatase family
CAC01_RS07685	COG2340	Cysteine-rich secretory protein family
CAC01_RS07690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAC01_RS07695	COG0571	ribonuclease III activity
CAC01_RS07700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAC01_RS07705	COG1399	metal-binding, possibly nucleic acid-binding protein
CAC01_RS07715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAC01_RS07720	COG0742	ribosomal rna small subunit methyltransferase
CAC01_RS07730	COG1461	Dihydroxyacetone kinase
CAC01_RS07735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAC01_RS07740	COG0351	phosphomethylpyrimidine kinase
CAC01_RS07760	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAC01_RS07765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAC01_RS07775	COG1920	GTP binding
CAC01_RS07785	COG0776	regulation of translation
CAC01_RS07795	COG0066	3-isopropylmalate dehydratase activity
CAC01_RS07800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAC01_RS07805	COG1414	Transcriptional regulator
CAC01_RS07845	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAC01_RS07855	COG2018	Roadblock/LC7 domain
CAC01_RS07875	COG2018	Roadblock/LC7 domain
CAC01_RS07895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAC01_RS07905	COG2353	YceI-like domain
CAC01_RS07915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAC01_RS07920	COG0477	Major facilitator Superfamily
CAC01_RS07925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAC01_RS07930	COG0473	3-isopropylmalate dehydrogenase activity
CAC01_RS07945	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS07950	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS07955	COG0506	proline dehydrogenase activity
CAC01_RS07985	COG0477	Major facilitator Superfamily
CAC01_RS07990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAC01_RS07995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAC01_RS08000	COG0440	acetolactate synthase activity
CAC01_RS08025	COG0667	Aldo Keto reductase
CAC01_RS08030	COG2133	pyrroloquinoline quinone binding
CAC01_RS08055	COG2409	Drug exporters of the RND superfamily
CAC01_RS08070	COG0154	amidase activity
CAC01_RS08075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAC01_RS08090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAC01_RS08100	COG4221	oxidoreductase activity
CAC01_RS08115	COG0482	sulfurtransferase activity
CAC01_RS08175	COG2860	membrane
CAC01_RS08180	COG4608	Belongs to the ABC transporter superfamily
CAC01_RS08185	COG0444	Belongs to the ABC transporter superfamily
CAC01_RS08195	COG4166	transmembrane transport
CAC01_RS08200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS08220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAC01_RS08225	COG0509	glycine decarboxylation via glycine cleavage system
CAC01_RS08230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAC01_RS08235	COG1760	l-serine dehydratase
CAC01_RS08250	COG1366	Belongs to the anti-sigma-factor antagonist family
CAC01_RS08255	COG1366	Belongs to the anti-sigma-factor antagonist family
CAC01_RS08260	COG2172	sigma factor antagonist activity
CAC01_RS08275	COG1136	(ABC) transporter
CAC01_RS08325	COG1131	(ABC) transporter
CAC01_RS08330	COG1132	(ABC) transporter
CAC01_RS08335	COG1132	(ABC) transporter
CAC01_RS08360	COG0366	Alpha amylase catalytic
CAC01_RS08370	COG3281	Trehalose synthase
CAC01_RS08375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAC01_RS08395	COG0789	Transcriptional regulator
CAC01_RS08410	COG3537	Alpha-1,2-mannosidase
CAC01_RS08420	COG3290	protein histidine kinase activity
CAC01_RS08425	COG4565	transcriptional regulatory protein
CAC01_RS08435	COG0205	6-phosphofructokinase activity
CAC01_RS08440	COG0280	phosphate acetyltransferase
CAC01_RS08440	COG0857	belongs to the CobB CobQ family
CAC01_RS08445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CAC01_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS08550	COG0745	RESPONSE REGULATOR receiver
CAC01_RS08565	COG0183	Belongs to the thiolase family
CAC01_RS08580	COG1131	(ABC) transporter
CAC01_RS08590	COG1131	(ABC) transporter
CAC01_RS08615	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CAC01_RS08630	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAC01_RS08675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAC01_RS08680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAC01_RS08685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAC01_RS08690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAC01_RS08695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAC01_RS08700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAC01_RS08705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAC01_RS08725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAC01_RS08735	COG2890	protein-(glutamine-N5) methyltransferase activity
CAC01_RS08740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAC01_RS08745	COG0254	rRNA binding
CAC01_RS08760	COG0083	homoserine kinase activity
CAC01_RS08765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CAC01_RS08770	COG0460	homoserine dehydrogenase
CAC01_RS08775	COG0019	diaminopimelate decarboxylase activity
CAC01_RS08780	COG0018	arginyl-trna synthetase
CAC01_RS08785	COG0745	RESPONSE REGULATOR receiver
CAC01_RS08835	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAC01_RS08845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAC01_RS08855	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CAC01_RS08865	COG1793	dna ligase
CAC01_RS08880	COG0768	penicillin binding
CAC01_RS08920	COG0642	Histidine kinase
CAC01_RS08940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAC01_RS08950	COG0745	RESPONSE REGULATOR receiver
CAC01_RS08955	COG2205	protein histidine kinase activity
CAC01_RS08960	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAC01_RS08960	COG0567	Dehydrogenase, E1 component
CAC01_RS09060	COG4106	trans-aconitate 2-methyltransferase activity
CAC01_RS09105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAC01_RS09160	COG1597	lipid kinase activity
CAC01_RS09175	COG0363	glucosamine-6-phosphate deaminase activity
CAC01_RS09180	COG1472	Belongs to the glycosyl hydrolase 3 family
CAC01_RS09185	COG0395	ABC-type sugar transport system, permease component
CAC01_RS09190	COG1175	transmembrane transport
CAC01_RS09195	COG2182	Extracellular solute-binding protein
CAC01_RS09220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAC01_RS09225	COG2124	cytochrome p450
CAC01_RS09235	COG0242	peptide deformylase activity
CAC01_RS09245	COG5662	AntiSigma factor
CAC01_RS09250	COG1595	DNA-templated transcription, initiation
CAC01_RS09260	COG2135	peptidase activity
CAC01_RS09270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAC01_RS09280	COG2076	Multidrug Resistance protein
CAC01_RS09285	COG0483	inositol monophosphate 1-phosphatase activity
CAC01_RS09290	COG0753	catalase activity
CAC01_RS09315	COG1615	UPF0182 protein
CAC01_RS09325	COG3480	Lon protease (S16) C-terminal proteolytic domain
CAC01_RS09340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAC01_RS09385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAC01_RS09445	COG0596	Alpha beta hydrolase
CAC01_RS09485	COG0601	transmembrane transport
CAC01_RS09490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS09495	COG0747	negative chemotaxis
CAC01_RS09540	COG0513	Belongs to the DEAD box helicase family
CAC01_RS09550	COG1432	Conserved Protein
CAC01_RS09560	COG2095	MarC family integral membrane protein
CAC01_RS09580	COG0598	Magnesium transport protein CorA
CAC01_RS09595	COG2239	Acts as a magnesium transporter
CAC01_RS09615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAC01_RS09620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAC01_RS09625	COG1595	DNA-templated transcription, initiation
CAC01_RS09640	COG1024	Enoyl-CoA hydratase
CAC01_RS09645	COG0519	Catalyzes the synthesis of GMP from XMP
CAC01_RS09655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CAC01_RS09685	COG1611	Belongs to the LOG family
CAC01_RS09690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAC01_RS09715	COG0456	acetyltransferase
CAC01_RS09725	COG2197	response regulator
CAC01_RS09730	COG4585	Histidine kinase
CAC01_RS09740	COG1131	(ABC) transporter
CAC01_RS09755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAC01_RS09775	COG4608	Belongs to the ABC transporter superfamily
CAC01_RS09780	COG0444	Belongs to the ABC transporter superfamily
CAC01_RS09785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS09790	COG0601	transmembrane transport
CAC01_RS09800	COG4608	Belongs to the ABC transporter superfamily
CAC01_RS09805	COG0444	Belongs to the ABC transporter superfamily
CAC01_RS09810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS09815	COG0601	transmembrane transport
CAC01_RS09820	COG0747	negative chemotaxis
CAC01_RS09825	COG1217	gtp-binding protein TYPA
CAC01_RS09840	COG1335	isochorismatase
CAC01_RS09910	COG1175	transmembrane transport
CAC01_RS09915	COG0395	ABC-type sugar transport system, permease component
CAC01_RS09960	COG0436	Aminotransferase
CAC01_RS09965	COG1733	regulation of RNA biosynthetic process
CAC01_RS10035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CAC01_RS10040	COG1946	Acyl-CoA thioesterase
CAC01_RS10055	COG1072	(Pantothenic acid kinase))
CAC01_RS10060	COG2267	carboxylic ester hydrolase activity
CAC01_RS10070	COG2814	Major facilitator Superfamily
CAC01_RS10075	COG1309	transcriptional regulator
CAC01_RS10080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAC01_RS10095	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS10110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAC01_RS10115	COG0589	response to stress
CAC01_RS10125	COG4977	sequence-specific DNA binding
CAC01_RS10130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CAC01_RS10145	COG0450	alkyl hydroperoxide reductase
CAC01_RS10150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAC01_RS10165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAC01_RS10170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAC01_RS10175	COG0667	Aldo Keto reductase
CAC01_RS10195	COG2885	chlorophyll binding
CAC01_RS10215	COG2197	response regulator
CAC01_RS10245	COG2894	cell division
CAC01_RS10275	COG0251	oxidation-reduction process
CAC01_RS10280	COG1414	Transcriptional regulator
CAC01_RS10295	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAC01_RS10310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAC01_RS10315	COG4948	Mandelate Racemase Muconate Lactonizing
CAC01_RS10350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS10360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAC01_RS10365	COG0765	amino acid transport
CAC01_RS10370	COG0765	amino acid transport
CAC01_RS10375	COG1126	abc transporter atp-binding protein
CAC01_RS10425	COG1674	ftsk spoiiie
CAC01_RS10465	COG0673	inositol 2-dehydrogenase activity
CAC01_RS10470	COG4702	Belongs to the UPF0303 family
CAC01_RS10475	COG0706	membrane insertase activity
CAC01_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS10520	COG2733	membrane
CAC01_RS10550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAC01_RS10555	COG2076	Multidrug Resistance protein
CAC01_RS10605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CAC01_RS10610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAC01_RS10615	COG1263	PTS System
CAC01_RS10620	COG1234	tRNA 3'-trailer cleavage
CAC01_RS10645	COG1113	amino acid transport
CAC01_RS10655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CAC01_RS10665	COG1335	isochorismatase
CAC01_RS10705	COG0277	FAD linked oxidase domain protein
CAC01_RS10715	COG1522	sequence-specific DNA binding
CAC01_RS10720	COG1174	glycine betaine transport
CAC01_RS10725	COG1125	glycine betaine transport
CAC01_RS10725	COG0517	IMP dehydrogenase activity
CAC01_RS10730	COG1174	glycine betaine transport
CAC01_RS10735	COG1732	Glycine betaine
CAC01_RS10770	COG3654	unkown
CAC01_RS10775	COG0181	hydroxymethylbilane synthase activity
CAC01_RS10825	COG0367	asparagine synthase
CAC01_RS10835	COG1309	transcriptional regulator
CAC01_RS10855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAC01_RS10860	COG2080	2 iron, 2 sulfur cluster binding
CAC01_RS10870	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CAC01_RS10880	COG1678	Uncharacterized ACR, COG1678
CAC01_RS10885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAC01_RS10890	COG0776	regulation of translation
CAC01_RS10900	COG2130	NADP-dependent
CAC01_RS10920	COG0210	DNA helicase
CAC01_RS10950	COG0583	DNA-binding transcription factor activity
CAC01_RS10960	COG2124	cytochrome p450
CAC01_RS10965	COG2130	NADP-dependent
CAC01_RS10970	COG1233	COG1233 Phytoene dehydrogenase and related
CAC01_RS10995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAC01_RS11000	COG0793	Belongs to the peptidase S41A family
CAC01_RS11000	COG3409	Peptidoglycan-binding domain 1 protein
CAC01_RS11010	COG2884	Cell division ATP-binding protein ftsE
CAC01_RS11025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CAC01_RS11035	COG0515	serine threonine protein kinase
CAC01_RS11040	COG0515	serine threonine protein kinase
CAC01_RS11045	COG1674	ftsk spoiiie
CAC01_RS11055	COG1082	Xylose isomerase domain protein TIM barrel
CAC01_RS11080	COG1175	transmembrane transport
CAC01_RS11085	COG0395	ABC-type sugar transport system, permease component
CAC01_RS11115	COG1309	transcriptional regulator
CAC01_RS11125	COG1134	teichoic acid transport
CAC01_RS11130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CAC01_RS11135	COG1215	transferase activity, transferring glycosyl groups
CAC01_RS11140	COG2902	Dehydrogenase
CAC01_RS11165	COG0653	protein targeting
CAC01_RS11180	COG0583	DNA-binding transcription factor activity
CAC01_RS11200	COG2197	response regulator
CAC01_RS11205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CAC01_RS11210	COG1040	competence protein
CAC01_RS11235	COG0823	Involved in the tonB-independent uptake of proteins
CAC01_RS11240	COG5002	protein histidine kinase activity
CAC01_RS11240	COG5000	phosphorelay sensor kinase activity
CAC01_RS11245	COG0745	RESPONSE REGULATOR receiver
CAC01_RS11295	COG1940	carbohydrate kinase activity
CAC01_RS11300	COG4209	transmembrane transport
CAC01_RS11305	COG0395	ABC-type sugar transport system, permease component
CAC01_RS11325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CAC01_RS11340	COG1482	cell wall glycoprotein biosynthetic process
CAC01_RS11395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CAC01_RS11400	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CAC01_RS11400	COG0778	Nitroreductase
CAC01_RS11435	COG1316	TRANSCRIPTIONal
CAC01_RS11440	COG1316	TRANSCRIPTIONal
CAC01_RS11450	COG1316	TRANSCRIPTIONal
CAC01_RS11455	COG1607	acyl-coa hydrolase
CAC01_RS11460	COG1316	TRANSCRIPTIONal
CAC01_RS11485	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS11490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CAC01_RS11510	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CAC01_RS11525	COG2205	protein histidine kinase activity
CAC01_RS11535	COG0745	RESPONSE REGULATOR receiver
CAC01_RS11540	COG3104	oligopeptide transport
CAC01_RS11550	COG1366	Belongs to the anti-sigma-factor antagonist family
CAC01_RS11555	COG1191	sigma factor activity
CAC01_RS11570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAC01_RS11575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAC01_RS11610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAC01_RS11680	COG0667	Aldo Keto reductase
CAC01_RS11745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAC01_RS11750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAC01_RS11755	COG0049	tRNA binding
CAC01_RS11760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAC01_RS11780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAC01_RS11785	COG0085	RNA polymerase activity
CAC01_RS11795	COG0222	ribosome binding
CAC01_RS11800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAC01_RS11815	COG0081	regulation of translation
CAC01_RS11825	COG0250	Participates in transcription elongation, termination and antitermination
CAC01_RS11840	COG0436	Aminotransferase
CAC01_RS11845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAC01_RS11855	COG1309	transcriptional regulator
CAC01_RS11865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAC01_RS11885	COG2030	dehydratase
CAC01_RS11890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAC01_RS11910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAC01_RS11930	COG1666	GTP binding
CAC01_RS11935	COG2261	transglycosylase associated protein
CAC01_RS11945	COG0501	Belongs to the peptidase M48B family
CAC01_RS11950	COG1007	ATP synthesis coupled electron transport
CAC01_RS11965	COG0713	ATP synthesis coupled electron transport
CAC01_RS11970	COG0839	Belongs to the complex I subunit 6 family
CAC01_RS11975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAC01_RS11985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAC01_RS11990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAC01_RS11995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAC01_RS12015	COG2197	response regulator
CAC01_RS12025	COG1013	pyruvate-flavodoxin oxidoreductase activity
CAC01_RS12030	COG1733	regulation of RNA biosynthetic process
CAC01_RS12035	COG0702	epimerase
CAC01_RS12050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAC01_RS12085	COG0456	acetyltransferase
CAC01_RS12125	COG3594	Acyltransferase
CAC01_RS12145	COG0142	geranyltranstransferase activity
CAC01_RS12170	COG0514	ATP-dependent DNA helicase (RecQ)
CAC01_RS12175	COG1007	ATP synthesis coupled electron transport
CAC01_RS12185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAC01_RS12190	COG0713	ATP synthesis coupled electron transport
CAC01_RS12195	COG0839	Belongs to the complex I subunit 6 family
CAC01_RS12200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAC01_RS12205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAC01_RS12210	COG1034	ATP synthesis coupled electron transport
CAC01_RS12215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAC01_RS12225	COG0649	NAD binding
CAC01_RS12230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAC01_RS12235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAC01_RS12305	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CAC01_RS12310	COG2159	amidohydrolase
CAC01_RS12335	COG2226	methyltransferase
CAC01_RS12360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CAC01_RS12370	COG0318	PFAM AMP-dependent synthetase and ligase
CAC01_RS12380	COG3433	isochorismatase activity
CAC01_RS12380	COG1535	isochorismatase
CAC01_RS12385	COG0477	Major facilitator Superfamily
CAC01_RS12425	COG0346	lactoylglutathione lyase activity
CAC01_RS12430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CAC01_RS12435	COG1120	ATPase activity
CAC01_RS12440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS12445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS12455	COG2936	dipeptidyl-peptidase activity
CAC01_RS12490	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CAC01_RS12510	COG1674	ftsk spoiiie
CAC01_RS12515	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CAC01_RS12520	COG1278	Cold shock
CAC01_RS12530	COG1301	dicarboxylic acid transport
CAC01_RS12545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CAC01_RS12555	COG0163	prenyltransferase activity
CAC01_RS12570	COG0109	protoheme IX farnesyltransferase activity
CAC01_RS12575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAC01_RS12600	COG2409	Drug exporters of the RND superfamily
CAC01_RS12610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAC01_RS12625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAC01_RS12630	COG0406	alpha-ribazole phosphatase activity
CAC01_RS12635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAC01_RS12650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAC01_RS12700	COG1742	UPF0060 membrane protein
CAC01_RS12715	COG1690	Belongs to the RtcB family
CAC01_RS12735	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CAC01_RS12740	COG0018	arginyl-trna synthetase
CAC01_RS12750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAC01_RS12775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAC01_RS12785	COG0586	Pfam SNARE associated Golgi protein
CAC01_RS12800	COG0477	Major facilitator Superfamily
CAC01_RS12820	COG2318	DinB family
CAC01_RS12845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAC01_RS12865	COG0113	porphobilinogen synthase activity
CAC01_RS12870	COG1648	precorrin-2 dehydrogenase activity
CAC01_RS12870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAC01_RS12875	COG0181	hydroxymethylbilane synthase activity
CAC01_RS12885	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CAC01_RS12930	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAC01_RS12935	COG0738	Major facilitator superfamily
CAC01_RS12940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAC01_RS12975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CAC01_RS12985	COG0842	Transport permease protein
CAC01_RS12985	COG1129	ABC transporter
CAC01_RS13000	COG0129	dihydroxy-acid dehydratase activity
CAC01_RS13010	COG1082	Xylose isomerase domain protein TIM barrel
CAC01_RS13015	COG0248	Ppx GppA phosphatase
CAC01_RS13035	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CAC01_RS13045	COG0671	phosphoesterase, PA-phosphatase related
CAC01_RS13050	COG2197	response regulator
CAC01_RS13055	COG4585	Histidine kinase
CAC01_RS13065	COG1595	DNA-templated transcription, initiation
CAC01_RS13075	COG0745	RESPONSE REGULATOR receiver
CAC01_RS13080	COG2205	protein histidine kinase activity
CAC01_RS13105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CAC01_RS13125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CAC01_RS13135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CAC01_RS13140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CAC01_RS13160	COG2197	response regulator
CAC01_RS13175	COG0649	NAD binding
CAC01_RS13200	COG1174	glycine betaine transport
CAC01_RS13205	COG1174	glycine betaine transport
CAC01_RS13210	COG0517	IMP dehydrogenase activity
CAC01_RS13210	COG1125	glycine betaine transport
CAC01_RS13225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CAC01_RS13240	COG0302	gtp cyclohydrolase
CAC01_RS13255	COG0037	tRNA processing
CAC01_RS13265	COG2027	D-alanyl-D-alanine carboxypeptidase
CAC01_RS13270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAC01_RS13280	COG0586	Pfam SNARE associated Golgi protein
CAC01_RS13290	COG0076	glutamate decarboxylase activity
CAC01_RS13295	COG2318	DinB family
CAC01_RS13300	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS13320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAC01_RS13335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAC01_RS13335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAC01_RS13345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CAC01_RS13450	COG0492	ferredoxin-NADP+ reductase activity
CAC01_RS13475	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS13500	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS13530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAC01_RS13535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAC01_RS13555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAC01_RS13585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CAC01_RS13590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAC01_RS13595	COG1754	DNA topoisomerase type I activity
CAC01_RS13595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAC01_RS13605	COG2890	protein-(glutamine-N5) methyltransferase activity
CAC01_RS13620	COG1366	Belongs to the anti-sigma-factor antagonist family
CAC01_RS13625	COG1205	dead DEAH box helicase
CAC01_RS13625	COG1111	helicase
CAC01_RS13675	COG2815	serine threonine protein kinase
CAC01_RS13675	COG0515	serine threonine protein kinase
CAC01_RS13685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CAC01_RS13690	COG0494	nUDIX hydrolase
CAC01_RS13695	COG0367	asparagine synthase
CAC01_RS13760	COG0659	secondary active sulfate transmembrane transporter activity
CAC01_RS13765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAC01_RS13770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CAC01_RS13780	COG0596	Alpha beta hydrolase
CAC01_RS13790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAC01_RS13815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAC01_RS13840	COG0003	Pfam Anion-transporting ATPase
CAC01_RS13855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAC01_RS13865	COG1408	metallophosphoesterase
CAC01_RS13890	COG3973	AAA domain
CAC01_RS13915	COG2186	Transcriptional regulator
CAC01_RS13920	COG2188	Transcriptional regulator
CAC01_RS13925	COG0456	acetyltransferase
CAC01_RS13940	COG3321	synthase
CAC01_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS13940	COG0604	alcohol dehydrogenase
CAC01_RS13950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAC01_RS13960	COG0494	nUDIX hydrolase
CAC01_RS13960	COG0406	alpha-ribazole phosphatase activity
CAC01_RS14045	COG0737	Belongs to the 5'-nucleotidase family
CAC01_RS14050	COG4552	Acetyltransferase involved in intracellular survival and related
CAC01_RS14065	COG1490	D-aminoacyl-tRNA deacylase activity
CAC01_RS14075	COG0735	belongs to the Fur family
CAC01_RS14080	COG3485	protocatechuate 3,4-dioxygenase
CAC01_RS14125	COG2897	thiosulfate sulfurtransferase activity
CAC01_RS14150	COG0745	RESPONSE REGULATOR receiver
CAC01_RS14155	COG1609	Transcriptional regulator
CAC01_RS14160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAC01_RS14165	COG0745	RESPONSE REGULATOR receiver
CAC01_RS14200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAC01_RS14210	COG0306	phosphate transporter
CAC01_RS14220	COG1937	Protein conserved in bacteria
CAC01_RS14235	COG1196	nuclear chromosome segregation
CAC01_RS14235	COG0741	lytic transglycosylase activity
CAC01_RS14235	COG0739	heme binding
CAC01_RS14295	COG1846	Transcriptional regulator
CAC01_RS14340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAC01_RS14350	COG0667	Aldo Keto reductase
CAC01_RS14390	COG4221	oxidoreductase activity
CAC01_RS14400	COG0477	Major facilitator Superfamily
CAC01_RS14410	COG4106	trans-aconitate 2-methyltransferase activity
CAC01_RS14435	COG0513	Belongs to the DEAD box helicase family
CAC01_RS14470	COG1643	Atp-dependent helicase
CAC01_RS14500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAC01_RS14510	COG0596	Alpha beta hydrolase
CAC01_RS14515	COG3903	Transcriptional regulator
CAC01_RS14515	COG3629	intracellular signal transduction
CAC01_RS14535	COG1309	transcriptional regulator
CAC01_RS14540	COG2814	Major facilitator Superfamily
CAC01_RS14550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAC01_RS14555	COG0047	phosphoribosylformylglycinamidine synthase activity
CAC01_RS14560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAC01_RS14595	COG2197	response regulator
CAC01_RS14605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAC01_RS14620	COG0151	Belongs to the GarS family
CAC01_RS14655	COG0515	serine threonine protein kinase
CAC01_RS14655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAC01_RS14660	COG1595	DNA-templated transcription, initiation
CAC01_RS14665	COG1846	Transcriptional regulator
CAC01_RS14705	COG3594	Acyltransferase
CAC01_RS14720	COG1064	alcohol dehydrogenase
CAC01_RS14750	COG4977	sequence-specific DNA binding
CAC01_RS14765	COG3634	alkyl hydroperoxide reductase activity
CAC01_RS14785	COG2268	Band 7 protein
CAC01_RS14820	COG1215	transferase activity, transferring glycosyl groups
CAC01_RS14835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAC01_RS14840	COG1309	transcriptional regulator
CAC01_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS14855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAC01_RS14870	COG2304	oxidoreductase activity
CAC01_RS14875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAC01_RS14885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAC01_RS14950	COG2267	carboxylic ester hydrolase activity
CAC01_RS14960	COG1362	aminopeptidase activity
CAC01_RS14965	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS15020	COG1309	transcriptional regulator
CAC01_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS15030	COG1741	Belongs to the pirin family
CAC01_RS15045	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAC01_RS15050	COG0022	dehydrogenase e1 component
CAC01_RS15060	COG0515	serine threonine protein kinase
CAC01_RS15065	COG0515	serine threonine protein kinase
CAC01_RS15080	COG3321	synthase
CAC01_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS15080	COG0604	alcohol dehydrogenase
CAC01_RS15090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAC01_RS15120	COG1522	sequence-specific DNA binding
CAC01_RS15130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAC01_RS15145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAC01_RS15160	COG1733	regulation of RNA biosynthetic process
CAC01_RS15165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAC01_RS15175	COG1716	ATPase activity
CAC01_RS15180	COG1716	ATPase activity
CAC01_RS15200	COG0515	serine threonine protein kinase
CAC01_RS15205	COG3764	Sortase (surface protein transpeptidase)
CAC01_RS15210	COG3764	Sortase (surface protein transpeptidase)
CAC01_RS15235	COG0705	Rhomboid family
CAC01_RS15265	COG0515	serine threonine protein kinase
CAC01_RS15295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CAC01_RS15300	COG0187	DNA topoisomerase II activity
CAC01_RS15305	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CAC01_RS15310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAC01_RS15315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAC01_RS15320	COG0592	DNA-directed DNA polymerase activity
CAC01_RS15325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAC01_RS15335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CAC01_RS15340	COG0594	ribonuclease P activity
CAC01_RS15345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAC01_RS15350	COG0706	membrane insertase activity
CAC01_RS15360	COG0357	Ribosomal RNA small subunit methyltransferase G
CAC01_RS15365	COG1192	Involved in chromosome partitioning
CAC01_RS15380	COG3118	belongs to the thioredoxin family
CAC01_RS15385	COG0492	ferredoxin-NADP+ reductase activity
CAC01_RS15395	COG1595	DNA-templated transcription, initiation
CAC01_RS15415	COG0617	tRNA 3'-terminal CCA addition
CAC01_RS15435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAC01_RS15460	COG0360	Binds together with S18 to 16S ribosomal RNA
CAC01_RS15465	COG0629	single-stranded DNA binding
CAC01_RS15470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAC01_RS15475	COG0359	binds to the 23S rRNA
CAC01_RS15485	COG0305	Participates in initiation and elongation during chromosome replication
CAC01_RS15510	COG0456	acetyltransferase
CAC01_RS15535	COG0626	cystathionine gamma-synthase activity
CAC01_RS15540	COG1950	PFAM Membrane protein of
CAC01_RS15545	COG0662	Cupin 2, conserved barrel domain protein
CAC01_RS15565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CAC01_RS15585	COG1609	Transcriptional regulator
CAC01_RS15590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAC01_RS15595	COG1271	oxidase subunit
CAC01_RS15600	COG1294	oxidase, subunit
CAC01_RS15605	COG4988	ABC transporter
CAC01_RS15610	COG1196	nuclear chromosome segregation
CAC01_RS15610	COG0739	heme binding
CAC01_RS15610	COG0741	lytic transglycosylase activity
CAC01_RS15615	COG0561	phosphatase activity
CAC01_RS15625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAC01_RS15630	COG3404	Formiminotransferase-cyclodeaminase
CAC01_RS15655	COG1131	(ABC) transporter
CAC01_RS15670	COG0561	phosphatase activity
CAC01_RS15675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAC01_RS15680	COG2837	iron assimilation
CAC01_RS15685	COG1276	copper resistance
CAC01_RS15715	COG0006	proline dipeptidase activity
CAC01_RS15730	COG0653	protein targeting
CAC01_RS15745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAC01_RS15790	COG1595	DNA-templated transcription, initiation
CAC01_RS15795	COG0318	PFAM AMP-dependent synthetase and ligase
CAC01_RS15805	COG1620	l-lactate permease
CAC01_RS15810	COG0247	lactate metabolic process
CAC01_RS15815	COG1139	Iron-sulfur cluster binding protein
CAC01_RS15820	COG1556	Lactate utilization protein
CAC01_RS15860	COG0745	RESPONSE REGULATOR receiver
CAC01_RS15870	COG3467	pyridoxamine 5'-phosphate
CAC01_RS15900	COG1191	sigma factor activity
CAC01_RS15905	COG1191	sigma factor activity
CAC01_RS16070	COG0667	Aldo Keto reductase
CAC01_RS16115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAC01_RS16130	COG0702	epimerase
CAC01_RS16145	COG0588	phosphoglycerate mutase activity
CAC01_RS16150	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS16150	COG3321	synthase
CAC01_RS16150	COG0604	alcohol dehydrogenase
CAC01_RS16170	COG1595	DNA-templated transcription, initiation
CAC01_RS16195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAC01_RS16215	COG1785	Belongs to the alkaline phosphatase family
CAC01_RS16230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAC01_RS16280	COG2814	Major facilitator Superfamily
CAC01_RS16290	COG3046	protein related to deoxyribodipyrimidine photolyase
CAC01_RS16295	COG0667	Aldo Keto reductase
CAC01_RS16305	COG0148	phosphopyruvate hydratase activity
CAC01_RS16340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAC01_RS16460	COG0717	Belongs to the dCTP deaminase family
CAC01_RS16485	COG2181	nitrate reductase activity
CAC01_RS16485	COG0247	lactate metabolic process
CAC01_RS16490	COG0443	Heat shock 70 kDa protein
CAC01_RS16495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAC01_RS16500	COG0484	heat shock protein binding
CAC01_RS16505	COG0789	Transcriptional regulator
CAC01_RS16530	COG0542	response to heat
CAC01_RS16565	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CAC01_RS16585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAC01_RS16590	COG0191	fructose-bisphosphate aldolase activity
CAC01_RS16600	COG3483	tryptophan 2,3-dioxygenase activity
CAC01_RS16605	COG3844	kynureninase activity
CAC01_RS16615	COG4585	Histidine kinase
CAC01_RS16620	COG2197	response regulator
CAC01_RS16630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAC01_RS16635	COG0477	Major facilitator Superfamily
CAC01_RS16660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAC01_RS16665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAC01_RS16670	COG1802	Transcriptional regulator
CAC01_RS16685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAC01_RS16690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAC01_RS16700	COG1309	transcriptional regulator
CAC01_RS16725	COG0789	Transcriptional regulator
CAC01_RS16730	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS16755	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CAC01_RS16775	COG1595	DNA-templated transcription, initiation
CAC01_RS16785	COG2362	D-Aminopeptidase
CAC01_RS16790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CAC01_RS16795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS16800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS16805	COG1120	ATPase activity
CAC01_RS16830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAC01_RS16845	COG1309	transcriptional regulator
CAC01_RS16850	COG0702	epimerase
CAC01_RS16865	COG1309	transcriptional regulator
CAC01_RS16895	COG1595	DNA-templated transcription, initiation
CAC01_RS16920	COG1794	racemase activity, acting on amino acids and derivatives
CAC01_RS16955	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS16975	COG2271	Major facilitator Superfamily
CAC01_RS16980	COG0588	phosphoglycerate mutase activity
CAC01_RS17025	COG5002	protein histidine kinase activity
CAC01_RS17050	COG1329	Transcriptional regulator
CAC01_RS17055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAC01_RS17060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAC01_RS17085	COG0215	cysteine-tRNA ligase activity
CAC01_RS17090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAC01_RS17105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAC01_RS17115	COG3842	ATPase activity
CAC01_RS17130	COG0483	inositol monophosphate 1-phosphatase activity
CAC01_RS17140	COG2319	Wd-40 repeat
CAC01_RS17140	COG5635	Nacht domain
CAC01_RS17165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAC01_RS17190	COG1595	DNA-templated transcription, initiation
CAC01_RS17205	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS17240	COG2186	Transcriptional regulator
CAC01_RS17250	COG1175	transmembrane transport
CAC01_RS17255	COG0395	ABC-type sugar transport system, permease component
CAC01_RS17260	COG4948	Mandelate Racemase Muconate Lactonizing
CAC01_RS17280	COG3469	chitinase activity
CAC01_RS17320	COG0477	Major facilitator Superfamily
CAC01_RS17355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAC01_RS17395	COG2197	response regulator
CAC01_RS17410	COG0666	response to abiotic stimulus
CAC01_RS17435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAC01_RS17455	COG1105	Belongs to the carbohydrate kinase PfkB family
CAC01_RS17460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CAC01_RS17480	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CAC01_RS17485	COG0463	Glycosyl transferase, family 2
CAC01_RS17500	COG1278	Cold shock
CAC01_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS17535	COG0454	-acetyltransferase
CAC01_RS17545	COG0412	Dienelactone hydrolase
CAC01_RS17555	COG1584	GPR1 FUN34 yaaH family protein
CAC01_RS17560	COG1263	PTS System
CAC01_RS17560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAC01_RS17565	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CAC01_RS17570	COG1737	Transcriptional regulator
CAC01_RS17595	COG3973	AAA domain
CAC01_RS17600	COG1061	Type III restriction enzyme res subunit
CAC01_RS17645	COG1278	Cold shock
CAC01_RS17650	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CAC01_RS17655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAC01_RS17665	COG2814	Major facilitator Superfamily
CAC01_RS17680	COG0500	methyltransferase
CAC01_RS17690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CAC01_RS17710	COG2252	PERMEase
CAC01_RS17735	COG4977	sequence-specific DNA binding
CAC01_RS17750	COG0667	Aldo Keto reductase
CAC01_RS17765	COG2318	DinB family
CAC01_RS17790	COG2945	thiolester hydrolase activity
CAC01_RS17790	COG0596	Alpha beta hydrolase
CAC01_RS17815	COG0667	Aldo Keto reductase
CAC01_RS17840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAC01_RS17845	COG0247	lactate metabolic process
CAC01_RS17845	COG0277	FAD linked oxidase domain protein
CAC01_RS17855	COG0110	maltose O-acetyltransferase activity
CAC01_RS17860	COG0583	DNA-binding transcription factor activity
CAC01_RS17880	COG0259	pyridoxamine-phosphate oxidase activity
CAC01_RS17890	COG4821	SIS domain
CAC01_RS17900	COG2945	thiolester hydrolase activity
CAC01_RS17900	COG0596	Alpha beta hydrolase
CAC01_RS17950	COG1366	Belongs to the anti-sigma-factor antagonist family
CAC01_RS17970	COG2072	flavoprotein involved in K transport
CAC01_RS17975	COG0259	pyridoxamine-phosphate oxidase activity
CAC01_RS17980	COG1309	transcriptional regulator
CAC01_RS17990	COG0515	serine threonine protein kinase
CAC01_RS17990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAC01_RS18015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CAC01_RS18045	COG1686	Belongs to the peptidase S11 family
CAC01_RS18080	COG1846	Transcriptional regulator
CAC01_RS18085	COG3384	dioxygenase
CAC01_RS18105	COG1247	-acetyltransferase
CAC01_RS18130	COG1970	mechanosensitive ion channel activity
CAC01_RS18145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CAC01_RS18165	COG3263	regulation of cellular component size
CAC01_RS18180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAC01_RS18185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAC01_RS18195	COG0315	cyclic pyranopterin monophosphate synthase activity
CAC01_RS18215	COG0501	Belongs to the peptidase M48B family
CAC01_RS18230	COG0708	Exodeoxyribonuclease III
CAC01_RS18245	COG2072	flavoprotein involved in K transport
CAC01_RS18250	COG2267	carboxylic ester hydrolase activity
CAC01_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS18270	COG0659	secondary active sulfate transmembrane transporter activity
CAC01_RS18285	COG2409	Drug exporters of the RND superfamily
CAC01_RS18310	COG0310	cobalt ion transport
CAC01_RS18320	COG1122	ATPase activity
CAC01_RS18325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAC01_RS18370	COG0084	hydrolase, TatD family'
CAC01_RS18380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAC01_RS18385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAC01_RS18395	COG0488	(ABC) transporter
CAC01_RS18430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CAC01_RS18435	COG2197	response regulator
CAC01_RS18450	COG4106	trans-aconitate 2-methyltransferase activity
CAC01_RS18470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAC01_RS18475	COG0193	aminoacyl-tRNA hydrolase activity
CAC01_RS18480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAC01_RS18485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAC01_RS18490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAC01_RS18505	COG4585	Histidine kinase
CAC01_RS18535	COG2949	membrane
CAC01_RS18540	COG0789	Transcriptional regulator
CAC01_RS18540	COG4978	Transcriptional regulator
CAC01_RS18555	COG0583	DNA-binding transcription factor activity
CAC01_RS18565	COG1136	(ABC) transporter
CAC01_RS18570	COG0577	efflux transmembrane transporter activity
CAC01_RS18610	COG0242	peptide deformylase activity
CAC01_RS18640	COG1136	(ABC) transporter
CAC01_RS18645	COG0577	efflux transmembrane transporter activity
CAC01_RS18675	COG3537	Alpha-1,2-mannosidase
CAC01_RS18690	COG4585	Histidine kinase
CAC01_RS18695	COG2197	response regulator
CAC01_RS18710	COG2124	cytochrome p450
CAC01_RS18715	COG1652	LysM domain
CAC01_RS18725	COG0148	phosphopyruvate hydratase activity
CAC01_RS18780	COG4221	oxidoreductase activity
CAC01_RS18795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAC01_RS18835	COG0183	Belongs to the thiolase family
CAC01_RS18840	COG2755	lipolytic protein G-D-S-L family
CAC01_RS18885	COG1595	DNA-templated transcription, initiation
CAC01_RS18895	COG0019	diaminopimelate decarboxylase activity
CAC01_RS18925	COG4221	oxidoreductase activity
CAC01_RS18940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CAC01_RS18950	COG0051	transcription antitermination factor activity, RNA binding
CAC01_RS18955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAC01_RS18960	COG0088	Forms part of the polypeptide exit tunnel
CAC01_RS18965	COG0089	rRNA binding
CAC01_RS18970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAC01_RS18975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAC01_RS18980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CAC01_RS18985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAC01_RS18990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAC01_RS18995	COG0255	Belongs to the universal ribosomal protein uL29 family
CAC01_RS19000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAC01_RS19005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CAC01_RS19010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAC01_RS19015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAC01_RS19020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CAC01_RS19030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAC01_RS19035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAC01_RS19040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAC01_RS19045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CAC01_RS19050	COG1841	ribosomal large subunit assembly
CAC01_RS19055	COG0200	Binds to the 23S rRNA
CAC01_RS19060	COG0201	protein transport
CAC01_RS19065	COG0563	adenylate kinase activity
CAC01_RS19075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CAC01_RS19080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CAC01_RS19085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CAC01_RS19090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CAC01_RS19100	COG0203	ribosomal protein L17
CAC01_RS19140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CAC01_RS19145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAC01_RS19150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAC01_RS19170	COG1072	(Pantothenic acid kinase))
CAC01_RS19175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAC01_RS19180	COG0736	holo-[acyl-carrier-protein] synthase activity
CAC01_RS19200	COG1051	belongs to the nudix hydrolase family
CAC01_RS19210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAC01_RS19220	COG0802	atpase or kinase
CAC01_RS19245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAC01_RS19285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAC01_RS19310	COG4221	oxidoreductase activity
CAC01_RS19320	COG0583	DNA-binding transcription factor activity
CAC01_RS19335	COG1595	DNA-templated transcription, initiation
CAC01_RS19345	COG0516	GMP reductase activity
CAC01_RS19360	COG0515	serine threonine protein kinase
CAC01_RS19360	COG2815	serine threonine protein kinase
CAC01_RS19370	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS19390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAC01_RS19390	COG0519	Catalyzes the synthesis of GMP from XMP
CAC01_RS19435	COG2197	response regulator
CAC01_RS19445	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CAC01_RS19480	COG0714	Associated with various cellular activities
CAC01_RS19490	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CAC01_RS19495	COG0045	succinate-CoA ligase (ADP-forming) activity
CAC01_RS19510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAC01_RS19540	COG0138	bifunctional purine biosynthesis protein purh
CAC01_RS19555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAC01_RS19570	COG0039	L-malate dehydrogenase activity
CAC01_RS19600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAC01_RS19605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAC01_RS19615	COG0754	glutathionylspermidine amidase activity
CAC01_RS19625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAC01_RS19635	COG0180	Tryptophanyl-tRNA synthetase
CAC01_RS19650	COG1295	ribonuclease BN
CAC01_RS19655	COG1686	Belongs to the peptidase S11 family
CAC01_RS19665	COG1408	metallophosphoesterase
CAC01_RS19695	COG2197	response regulator
CAC01_RS19705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAC01_RS19710	COG1053	succinate dehydrogenase
CAC01_RS19720	COG2009	succinate dehydrogenase
CAC01_RS19745	COG1595	DNA-templated transcription, initiation
CAC01_RS19785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAC01_RS19805	COG1216	Glycosyl transferase, family 2
CAC01_RS19815	COG1083	cytidylyl-transferase
CAC01_RS19820	COG2089	acid synthase
CAC01_RS19835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAC01_RS19835	COG1473	amidohydrolase
CAC01_RS19840	COG1744	ABC transporter substrate-binding protein PnrA-like
CAC01_RS19845	COG1744	ABC transporter substrate-binding protein PnrA-like
CAC01_RS19850	COG3845	ABC transporter
CAC01_RS19860	COG1079	Belongs to the binding-protein-dependent transport system permease family
CAC01_RS19875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAC01_RS19910	COG2205	protein histidine kinase activity
CAC01_RS19915	COG0745	RESPONSE REGULATOR receiver
CAC01_RS19930	COG2814	Major facilitator Superfamily
CAC01_RS19935	COG0583	DNA-binding transcription factor activity
CAC01_RS19940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CAC01_RS19965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAC01_RS19995	COG2205	protein histidine kinase activity
CAC01_RS20000	COG0745	RESPONSE REGULATOR receiver
CAC01_RS20005	COG1595	DNA-templated transcription, initiation
CAC01_RS20020	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS20025	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS20030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CAC01_RS20075	COG4770	biotin carboxylase activity
CAC01_RS20085	COG0424	maF-like protein
CAC01_RS20095	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAC01_RS20100	COG1024	Enoyl-CoA hydratase
CAC01_RS20110	COG2986	histidine ammonia-lyase
CAC01_RS20120	COG1376	ErfK ybiS ycfS ynhG family protein
CAC01_RS20130	COG1136	(ABC) transporter
CAC01_RS20130	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAC01_RS20140	COG1064	alcohol dehydrogenase
CAC01_RS20180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAC01_RS20190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAC01_RS20205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAC01_RS20225	COG2124	cytochrome p450
CAC01_RS20305	COG0477	Major facilitator Superfamily
CAC01_RS20315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAC01_RS20360	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS20365	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS20380	COG4941	Belongs to the sigma-70 factor family
CAC01_RS20390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAC01_RS20415	COG0243	molybdopterin cofactor binding
CAC01_RS20435	COG1278	Cold shock
CAC01_RS20440	COG0513	Belongs to the DEAD box helicase family
CAC01_RS20470	COG1331	Highly conserved protein containing a thioredoxin domain
CAC01_RS20480	COG1331	Highly conserved protein containing a thioredoxin domain
CAC01_RS20500	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CAC01_RS20510	COG0436	Aminotransferase
CAC01_RS20560	COG0406	alpha-ribazole phosphatase activity
CAC01_RS20595	COG2985	domain, Protein
CAC01_RS20600	COG2985	domain, Protein
CAC01_RS20625	COG2814	Major facilitator Superfamily
CAC01_RS20640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAC01_RS20645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAC01_RS20650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAC01_RS20670	COG0702	epimerase
CAC01_RS20760	COG1136	(ABC) transporter
CAC01_RS20780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAC01_RS20800	COG0114	fumarate hydratase activity
CAC01_RS20805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CAC01_RS20805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CAC01_RS20820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAC01_RS20825	COG0543	2 iron, 2 sulfur cluster binding
CAC01_RS20825	COG0633	Ferredoxin
CAC01_RS20845	COG0778	Nitroreductase
CAC01_RS20855	COG1722	exodeoxyribonuclease VII activity
CAC01_RS20860	COG1570	exodeoxyribonuclease VII activity
CAC01_RS20870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAC01_RS20885	COG0012	GTP binding
CAC01_RS20935	COG0534	Mate efflux family protein
CAC01_RS20945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAC01_RS20970	COG4948	Mandelate Racemase Muconate Lactonizing
CAC01_RS20980	COG1175	transmembrane transport
CAC01_RS20985	COG0395	ABC-type sugar transport system, permease component
CAC01_RS21005	COG0028	Belongs to the TPP enzyme family
CAC01_RS21045	COG0745	RESPONSE REGULATOR receiver
CAC01_RS21050	COG5002	protein histidine kinase activity
CAC01_RS21090	COG1472	Belongs to the glycosyl hydrolase 3 family
CAC01_RS21110	COG0673	inositol 2-dehydrogenase activity
CAC01_RS21130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAC01_RS21165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CAC01_RS21165	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CAC01_RS21170	COG3718	enzyme involved in inositol metabolism
CAC01_RS21175	COG3962	Belongs to the TPP enzyme family
CAC01_RS21195	COG0588	phosphoglycerate mutase activity
CAC01_RS21230	COG2814	Major facilitator Superfamily
CAC01_RS21240	COG0019	diaminopimelate decarboxylase activity
CAC01_RS21305	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS21325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAC01_RS21370	COG2208	phosphoserine phosphatase activity
CAC01_RS21370	COG2770	Histidine kinase
CAC01_RS21375	COG4412	M6 family metalloprotease domain protein
CAC01_RS21375	COG1404	Belongs to the peptidase S8 family
CAC01_RS21410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAC01_RS21420	COG0583	DNA-binding transcription factor activity
CAC01_RS21430	COG0629	single-stranded DNA binding
CAC01_RS21465	COG2346	COG2346, Truncated hemoglobins
CAC01_RS21470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAC01_RS21500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAC01_RS21515	COG1486	melibiose metabolic process
CAC01_RS21520	COG0395	ABC-type sugar transport system, permease component
CAC01_RS21525	COG1175	transmembrane transport
CAC01_RS21540	COG1846	Transcriptional regulator
CAC01_RS21540	COG1940	carbohydrate kinase activity
CAC01_RS21555	COG0668	transmembrane transport
CAC01_RS21565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS21570	COG2815	serine threonine protein kinase
CAC01_RS21570	COG0515	serine threonine protein kinase
CAC01_RS21580	COG0473	3-isopropylmalate dehydrogenase activity
CAC01_RS21585	COG1335	isochorismatase
CAC01_RS21590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CAC01_RS21635	COG0494	nUDIX hydrolase
CAC01_RS21655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAC01_RS21665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAC01_RS21670	COG1113	amino acid transport
CAC01_RS21680	COG1113	amino acid transport
CAC01_RS21685	COG0698	ribose 5-phosphate isomerase
CAC01_RS21695	COG4552	Acetyltransferase involved in intracellular survival and related
CAC01_RS21705	COG0475	glutathione-regulated potassium exporter activity
CAC01_RS21710	COG3594	Acyltransferase
CAC01_RS21740	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAC01_RS21745	COG0740	serine-type endopeptidase activity
CAC01_RS21750	COG0740	serine-type endopeptidase activity
CAC01_RS21755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAC01_RS21765	COG0525	valine-tRNA ligase activity
CAC01_RS21780	COG0285	dihydrofolate synthase activity
CAC01_RS21790	COG0105	UTP biosynthetic process
CAC01_RS21795	COG1077	Cell shape determining protein MreB Mrl
CAC01_RS21815	COG0772	Belongs to the SEDS family
CAC01_RS21835	COG1530	ribonuclease E activity
CAC01_RS21840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAC01_RS21845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAC01_RS21850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAC01_RS21855	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CAC01_RS21860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CAC01_RS21865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CAC01_RS21880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAC01_RS21890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAC01_RS21925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAC01_RS21935	COG0799	negative regulation of ribosome biogenesis
CAC01_RS21940	COG0588	phosphoglycerate mutase activity
CAC01_RS21960	COG0495	leucyl-tRNA aminoacylation
CAC01_RS21970	COG1307	EDD domain protein, DegV family
CAC01_RS21975	COG1555	photosystem II stabilization
CAC01_RS21975	COG1596	polysaccharide export
CAC01_RS22010	COG0268	Binds directly to 16S ribosomal RNA
CAC01_RS22015	COG0481	GTPase activity
CAC01_RS22020	COG1022	Amp-dependent synthetase and ligase
CAC01_RS22050	COG1420	regulation of RNA biosynthetic process
CAC01_RS22055	COG0484	heat shock protein binding
CAC01_RS22080	COG0793	Belongs to the peptidase S41A family
CAC01_RS22080	COG4946	Tricorn protease homolog
CAC01_RS22085	COG0537	adenosine 5'-monophosphoramidase activity
CAC01_RS22090	COG1234	tRNA 3'-trailer cleavage
CAC01_RS22095	COG3547	Transposase (IS116 IS110 IS902 family)
CAC01_RS22105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAC01_RS22115	COG1486	melibiose metabolic process
CAC01_RS22120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAC01_RS22135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAC01_RS22145	COG2315	Protein conserved in bacteria
CAC01_RS22165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAC01_RS22185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAC01_RS22205	COG0494	nUDIX hydrolase
CAC01_RS22220	COG0789	Transcriptional regulator
CAC01_RS22245	COG2318	DinB family
CAC01_RS22295	COG0739	heme binding
CAC01_RS22295	COG1196	nuclear chromosome segregation
CAC01_RS22295	COG0741	lytic transglycosylase activity
CAC01_RS22315	COG1222	aaa ATPase
CAC01_RS22405	COG1309	transcriptional regulator
CAC01_RS22420	COG0667	Aldo Keto reductase
CAC01_RS22435	COG1381	Involved in DNA repair and RecF pathway recombination
CAC01_RS22440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAC01_RS22455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAC01_RS22460	COG1121	(ABC) transporter
CAC01_RS22465	COG3443	Belongs to the bacterial solute-binding protein 9 family
CAC01_RS22465	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAC01_RS22470	COG0423	glycine-tRNA ligase activity
CAC01_RS22475	COG1357	PFAM Pentapeptide repeats (8 copies)
CAC01_RS22485	COG3291	Pkd domain containing protein
CAC01_RS22495	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS22505	COG0477	Major facilitator Superfamily
CAC01_RS22515	COG0531	amino acid
CAC01_RS22545	COG0346	lactoylglutathione lyase activity
CAC01_RS22560	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAC01_RS22565	COG1940	carbohydrate kinase activity
CAC01_RS22565	COG1846	Transcriptional regulator
CAC01_RS22590	COG2890	protein-(glutamine-N5) methyltransferase activity
CAC01_RS22595	COG0574	Belongs to the PEP-utilizing enzyme family
CAC01_RS22595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAC01_RS22640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CAC01_RS22670	COG0358	DNA primase activity
CAC01_RS22675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAC01_RS22690	COG1070	Carbohydrate kinase
CAC01_RS22715	COG3903	Transcriptional regulator
CAC01_RS22715	COG3629	intracellular signal transduction
CAC01_RS22730	COG0512	Glutamine amidotransferase of anthranilate synthase
CAC01_RS22740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAC01_RS22745	COG0475	glutathione-regulated potassium exporter activity
CAC01_RS22760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAC01_RS22765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAC01_RS22775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAC01_RS22780	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS22815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAC01_RS22870	COG1136	(ABC) transporter
CAC01_RS22880	COG2175	clavaminate synthase activity
CAC01_RS22895	COG3903	Transcriptional regulator
CAC01_RS22895	COG3629	intracellular signal transduction
CAC01_RS22900	COG3757	hydrolase, family 25
CAC01_RS22900	COG3409	Peptidoglycan-binding domain 1 protein
CAC01_RS22910	COG1077	Cell shape determining protein MreB Mrl
CAC01_RS22915	COG1404	Belongs to the peptidase S8 family
CAC01_RS22930	COG2130	NADP-dependent
CAC01_RS22940	COG0667	Aldo Keto reductase
CAC01_RS22945	COG1309	transcriptional regulator
CAC01_RS22965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAC01_RS22970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAC01_RS22975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAC01_RS23000	COG0789	Transcriptional regulator
CAC01_RS23015	COG1309	transcriptional regulator
CAC01_RS23020	COG0477	Major facilitator Superfamily
CAC01_RS23030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CAC01_RS23110	COG4106	trans-aconitate 2-methyltransferase activity
CAC01_RS23155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAC01_RS23160	COG1024	Enoyl-CoA hydratase
CAC01_RS23165	COG2124	cytochrome p450
CAC01_RS23270	COG4122	O-methyltransferase activity
CAC01_RS23310	COG3845	ABC transporter
CAC01_RS23325	COG1657	PFAM Prenyltransferase squalene oxidase
CAC01_RS23330	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS23365	COG1487	ribonuclease activity
CAC01_RS23375	COG0477	Major facilitator Superfamily
CAC01_RS23380	COG2030	dehydratase
CAC01_RS23400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CAC01_RS23415	COG0800	Aldolase
CAC01_RS23420	COG3022	response to hydroperoxide
CAC01_RS23455	COG0242	peptide deformylase activity
CAC01_RS23465	COG2890	protein-(glutamine-N5) methyltransferase activity
CAC01_RS23505	COG1609	Transcriptional regulator
CAC01_RS23510	COG4952	isomerase
CAC01_RS23515	COG3347	Dehydrogenase
CAC01_RS23515	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS23520	COG1070	Carbohydrate kinase
CAC01_RS23525	COG3540	Alkaline phosphatase
CAC01_RS23535	COG2814	Major facilitator Superfamily
CAC01_RS23550	COG1834	amidinotransferase
CAC01_RS23565	COG0672	)-iron permease
CAC01_RS23570	COG2837	iron assimilation
CAC01_RS23580	COG1120	ATPase activity
CAC01_RS23585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS23590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CAC01_RS23640	COG1994	Peptidase M50
CAC01_RS23660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAC01_RS23670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAC01_RS23670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CAC01_RS23675	COG0174	glutamine synthetase
CAC01_RS23680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CAC01_RS23695	COG0174	glutamine synthetase
CAC01_RS23710	COG1309	transcriptional regulator
CAC01_RS23720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAC01_RS23730	COG0366	Alpha amylase catalytic
CAC01_RS23745	COG1309	transcriptional regulator
CAC01_RS23755	COG2197	response regulator
CAC01_RS23770	COG0745	RESPONSE REGULATOR receiver
CAC01_RS23835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAC01_RS23840	COG0321	lipoyl(octanoyl) transferase activity
CAC01_RS23880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CAC01_RS23890	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAC01_RS23895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAC01_RS23900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAC01_RS23905	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CAC01_RS23915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAC01_RS23930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAC01_RS23935	COG2226	methyltransferase
CAC01_RS23960	COG4585	Histidine kinase
CAC01_RS23965	COG2197	response regulator
CAC01_RS23970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAC01_RS23975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CAC01_RS24000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAC01_RS24010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAC01_RS24015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAC01_RS24025	COG1376	ErfK ybiS ycfS ynhG family protein
CAC01_RS24035	COG1845	cytochrome c oxidase, subunit III
CAC01_RS24040	COG2010	Cytochrome c
CAC01_RS24045	COG0723	plastoquinol--plastocyanin reductase activity
CAC01_RS24050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAC01_RS24055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAC01_RS24060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAC01_RS24080	COG0791	NLP P60 protein
CAC01_RS24080	COG1388	LysM domain
CAC01_RS24080	COG3103	Sh3 type 3 domain protein
CAC01_RS24120	COG0003	Pfam Anion-transporting ATPase
CAC01_RS24130	COG1940	carbohydrate kinase activity
CAC01_RS24165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAC01_RS24175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CAC01_RS24185	COG2193	ferroxidase activity
CAC01_RS24190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAC01_RS24195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CAC01_RS24205	COG0515	serine threonine protein kinase
CAC01_RS24205	COG2815	serine threonine protein kinase
CAC01_RS24215	COG2022	thiamine diphosphate biosynthetic process
CAC01_RS24225	COG2022	thiamine diphosphate biosynthetic process
CAC01_RS24225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAC01_RS24240	COG0352	thiamine-phosphate diphosphorylase activity
CAC01_RS24260	COG1309	transcriptional regulator
CAC01_RS24270	COG1131	(ABC) transporter
CAC01_RS24310	COG0275	rRNA processing
CAC01_RS24320	COG0768	penicillin binding
CAC01_RS24325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAC01_RS24335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAC01_RS24340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAC01_RS24350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAC01_RS24355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAC01_RS24365	COG1496	oxidoreductase activity
CAC01_RS24375	COG1799	cell septum assembly
CAC01_RS24385	COG3599	regulation of cell shape
CAC01_RS24390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAC01_RS24400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAC01_RS24450	COG0587	DNA-directed DNA polymerase activity
CAC01_RS24455	COG1432	Conserved Protein
CAC01_RS24525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAC01_RS24545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAC01_RS24550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAC01_RS24555	COG0131	Imidazoleglycerol-phosphate dehydratase
CAC01_RS24560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAC01_RS24565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAC01_RS24570	COG0251	oxidation-reduction process
CAC01_RS24575	COG0107	imidazoleglycerol-phosphate synthase activity
CAC01_RS24585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CAC01_RS24590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAC01_RS24610	COG0134	indole-3-glycerol-phosphate synthase activity
CAC01_RS24620	COG0133	tryptophan synthase activity
CAC01_RS24625	COG0159	tryptophan synthase activity
CAC01_RS24635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAC01_RS24645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAC01_RS24650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAC01_RS24670	COG1397	ADP-ribosylglycohydrolase
CAC01_RS24680	COG0067	glutamate synthase
CAC01_RS24680	COG0069	glutamate synthase activity
CAC01_RS24680	COG0070	glutamate synthase
CAC01_RS24690	COG1278	Cold shock
CAC01_RS24700	COG5640	endopeptidase activity
CAC01_RS24710	COG1605	Chorismate mutase
CAC01_RS24710	COG0287	Prephenate dehydrogenase
CAC01_RS24735	COG0737	Belongs to the 5'-nucleotidase family
CAC01_RS24785	COG2050	protein possibly involved in aromatic compounds catabolism
CAC01_RS24790	COG0667	Aldo Keto reductase
CAC01_RS24810	COG1643	Atp-dependent helicase
CAC01_RS24820	COG0539	negative regulation of cytoplasmic translation
CAC01_RS24835	COG0237	dephospho-CoA kinase activity
CAC01_RS24850	COG2226	methyltransferase
CAC01_RS24865	COG0395	ABC-type sugar transport system, permease component
CAC01_RS24870	COG1175	transmembrane transport
CAC01_RS24875	COG2182	Extracellular solute-binding protein
CAC01_RS24880	COG2188	Transcriptional regulator
CAC01_RS24900	COG2838	Isocitrate dehydrogenase
CAC01_RS24905	COG2267	carboxylic ester hydrolase activity
CAC01_RS24955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAC01_RS24960	COG0584	glycerophosphoryl diester phosphodiesterase
CAC01_RS24965	COG0556	nucleotide-excision repair
CAC01_RS24980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAC01_RS24990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAC01_RS25000	COG0322	excinuclease ABC activity
CAC01_RS25005	COG1660	Displays ATPase and GTPase activities
CAC01_RS25015	COG1481	regulation of sporulation
CAC01_RS25025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAC01_RS25030	COG0126	phosphoglycerate kinase activity
CAC01_RS25035	COG0149	triose-phosphate isomerase activity
CAC01_RS25040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAC01_RS25055	COG0166	Belongs to the GPI family
CAC01_RS25065	COG0363	glucosamine-6-phosphate deaminase activity
CAC01_RS25080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAC01_RS25085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAC01_RS25095	COG0109	protoheme IX farnesyltransferase activity
CAC01_RS25115	COG1472	Belongs to the glycosyl hydrolase 3 family
CAC01_RS25120	COG0395	ABC-type sugar transport system, permease component
CAC01_RS25125	COG1175	transmembrane transport
CAC01_RS25135	COG1737	Transcriptional regulator
CAC01_RS25140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAC01_RS25150	COG1131	(ABC) transporter
CAC01_RS25175	COG0396	ATPase activity
CAC01_RS25180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAC01_RS25185	COG0822	iron-sulfur transferase activity
CAC01_RS25190	COG2151	metal-sulfur cluster biosynthetic enzyme
CAC01_RS25195	COG2076	Multidrug Resistance protein
CAC01_RS25200	COG3226	Transcriptional regulator
CAC01_RS25215	COG2171	N-acyltransferase activity
CAC01_RS25235	COG1132	(ABC) transporter
CAC01_RS25245	COG1472	Belongs to the glycosyl hydrolase 3 family
CAC01_RS25250	COG0395	ABC-type sugar transport system, permease component
CAC01_RS25255	COG1175	transmembrane transport
CAC01_RS25265	COG1609	Transcriptional regulator
CAC01_RS25295	COG1063	alcohol dehydrogenase
CAC01_RS25300	COG0395	ABC-type sugar transport system, permease component
CAC01_RS25315	COG1349	DNA-binding transcription factor activity
CAC01_RS25325	COG0768	penicillin binding
CAC01_RS25330	COG0477	Major facilitator Superfamily
CAC01_RS25355	COG5285	phytanoyl-CoA dioxygenase
CAC01_RS25360	COG1917	Cupin 2, conserved barrel domain protein
CAC01_RS25370	COG0456	acetyltransferase
CAC01_RS25400	COG1797	cobyrinic acid a,c-diamide synthase activity
CAC01_RS25415	COG1492	cobalamin metabolic process
CAC01_RS25420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CAC01_RS25440	COG0235	Class ii aldolase
CAC01_RS25455	COG0488	(ABC) transporter
CAC01_RS25465	COG1024	Enoyl-CoA hydratase
CAC01_RS25505	COG3387	PFAM Glycoside hydrolase 15-related
CAC01_RS25515	COG1199	ATP-dependent helicase activity
CAC01_RS25515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAC01_RS25540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAC01_RS25555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAC01_RS25560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAC01_RS25580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAC01_RS25585	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS25590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAC01_RS25595	COG2186	Transcriptional regulator
CAC01_RS25615	COG3830	Belongs to the UPF0237 family
CAC01_RS25615	COG0560	Phosphoserine phosphatase
CAC01_RS25620	COG0842	Transport permease protein
CAC01_RS25620	COG1716	ATPase activity
CAC01_RS25620	COG1131	(ABC) transporter
CAC01_RS25630	COG4585	Histidine kinase
CAC01_RS25635	COG2197	response regulator
CAC01_RS25655	COG1119	ATPase activity
CAC01_RS25675	COG1881	PFAM PEBP family protein
CAC01_RS25685	COG2094	Belongs to the DNA glycosylase MPG family
CAC01_RS25725	COG0647	UMP catabolic process
CAC01_RS25740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAC01_RS25745	COG0497	DNA recombination
CAC01_RS25760	COG3387	PFAM Glycoside hydrolase 15-related
CAC01_RS25765	COG0504	CTP synthase activity
CAC01_RS25770	COG0494	nUDIX hydrolase
CAC01_RS25780	COG0686	Belongs to the AlaDH PNT family
CAC01_RS25795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAC01_RS25800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAC01_RS25805	COG1187	pseudouridine synthase activity
CAC01_RS25810	COG1397	ADP-ribosylglycohydrolase
CAC01_RS25825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CAC01_RS25835	COG1160	GTP binding
CAC01_RS25850	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS25865	COG0671	phosphoesterase, PA-phosphatase related
CAC01_RS25870	COG1799	cell septum assembly
CAC01_RS25880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAC01_RS25885	COG0765	amino acid transport
CAC01_RS25895	COG1126	abc transporter atp-binding protein
CAC01_RS25905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS25920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAC01_RS25935	COG0587	DNA-directed DNA polymerase activity
CAC01_RS25950	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS25950	COG0604	alcohol dehydrogenase
CAC01_RS25950	COG3321	synthase
CAC01_RS25960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CAC01_RS25965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAC01_RS25985	COG0456	acetyltransferase
CAC01_RS25985	COG0454	-acetyltransferase
CAC01_RS25995	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS26000	COG1725	Transcriptional regulator
CAC01_RS26015	COG2755	lipolytic protein G-D-S-L family
CAC01_RS26055	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS26075	COG0789	Transcriptional regulator
CAC01_RS26105	COG3876	Protein conserved in bacteria
CAC01_RS26115	COG0318	PFAM AMP-dependent synthetase and ligase
CAC01_RS26145	COG2149	membrane
CAC01_RS26150	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CAC01_RS26180	COG3265	gluconokinase activity
CAC01_RS26185	COG2186	Transcriptional regulator
CAC01_RS26190	COG3012	SEC-C Motif Domain Protein
CAC01_RS26195	COG0702	epimerase
CAC01_RS26200	COG0406	alpha-ribazole phosphatase activity
CAC01_RS26210	COG0318	PFAM AMP-dependent synthetase and ligase
CAC01_RS26215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAC01_RS26220	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAC01_RS26220	COG1902	pentaerythritol trinitrate reductase activity
CAC01_RS26230	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS26235	COG0318	PFAM AMP-dependent synthetase and ligase
CAC01_RS26250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAC01_RS26280	COG0667	Aldo Keto reductase
CAC01_RS26285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS26295	COG0598	Magnesium transport protein CorA
CAC01_RS26300	COG0406	alpha-ribazole phosphatase activity
CAC01_RS26315	COG0215	cysteine-tRNA ligase activity
CAC01_RS26325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS26330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CAC01_RS26335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAC01_RS26340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAC01_RS26345	COG1414	Transcriptional regulator
CAC01_RS26355	COG1410	methionine synthase
CAC01_RS26355	COG0646	methionine synthase
CAC01_RS26360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAC01_RS26370	COG4166	transmembrane transport
CAC01_RS26375	COG2197	response regulator
CAC01_RS26385	COG0517	IMP dehydrogenase activity
CAC01_RS26385	COG1994	Peptidase M50
CAC01_RS26415	COG1222	aaa ATPase
CAC01_RS26420	COG4122	O-methyltransferase activity
CAC01_RS26430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CAC01_RS26435	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CAC01_RS26440	COG1609	Transcriptional regulator
CAC01_RS26450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CAC01_RS26485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAC01_RS26490	COG0805	protein transport
CAC01_RS26540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAC01_RS26545	COG0517	IMP dehydrogenase activity
CAC01_RS26545	COG4175	Glycine betaine
CAC01_RS26570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CAC01_RS26600	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS26650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAC01_RS26655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CAC01_RS26660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CAC01_RS26665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAC01_RS26670	COG5002	protein histidine kinase activity
CAC01_RS26675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAC01_RS26680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAC01_RS26680	COG0072	phenylalanine-tRNA ligase activity
CAC01_RS26690	COG1051	belongs to the nudix hydrolase family
CAC01_RS26695	COG1064	alcohol dehydrogenase
CAC01_RS26720	COG1649	PFAM Uncharacterised BCR, COG1649
CAC01_RS26725	COG0697	spore germination
CAC01_RS26760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAC01_RS26775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAC01_RS26780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CAC01_RS26785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAC01_RS26790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAC01_RS26795	COG1438	arginine binding
CAC01_RS26840	COG0385	Bile acid
CAC01_RS26850	COG3152	Membrane
CAC01_RS26860	COG3189	MarR family transcriptional regulator
CAC01_RS26865	COG0165	Argininosuccinate lyase
CAC01_RS26885	COG0477	Major facilitator Superfamily
CAC01_RS26910	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CAC01_RS26930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAC01_RS26935	COG2011	ABC-type metal ion transport system permease component
CAC01_RS26940	COG1464	Belongs to the NlpA lipoprotein family
CAC01_RS26955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAC01_RS26960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAC01_RS26960	COG1648	precorrin-2 dehydrogenase activity
CAC01_RS27010	COG0512	Glutamine amidotransferase of anthranilate synthase
CAC01_RS27010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAC01_RS27075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAC01_RS27080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAC01_RS27095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAC01_RS27100	COG1560	Kdo2-lipid A biosynthetic process
CAC01_RS27105	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS27115	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CAC01_RS27120	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CAC01_RS27125	COG0217	transcriptional regulatory protein
CAC01_RS27130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CAC01_RS27135	COG0632	four-way junction helicase activity
CAC01_RS27140	COG2255	four-way junction helicase activity
CAC01_RS27150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAC01_RS27155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAC01_RS27160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAC01_RS27165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAC01_RS27170	COG1196	nuclear chromosome segregation
CAC01_RS27175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAC01_RS27185	COG0124	histidyl-tRNA synthetase
CAC01_RS27210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CAC01_RS27225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAC01_RS27230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAC01_RS27235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAC01_RS27240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAC01_RS27245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAC01_RS27250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAC01_RS27255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAC01_RS27265	COG0006	proline dipeptidase activity
CAC01_RS27270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAC01_RS27275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAC01_RS27280	COG0076	glutamate decarboxylase activity
CAC01_RS27290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CAC01_RS27295	COG0540	Belongs to the ATCase OTCase family
CAC01_RS27300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAC01_RS27310	COG0505	Belongs to the CarA family
CAC01_RS27315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAC01_RS27320	COG0167	dihydroorotate dehydrogenase activity
CAC01_RS27325	COG0284	orotidine-5'-phosphate decarboxylase activity
CAC01_RS27335	COG0194	GDP metabolic process
CAC01_RS27340	COG1758	RNA polymerase activity
CAC01_RS27350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAC01_RS27365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAC01_RS27375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CAC01_RS27380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAC01_RS27385	COG2390	Transcriptional regulator
CAC01_RS27405	COG2208	phosphoserine phosphatase activity
CAC01_RS27405	COG2770	Histidine kinase
CAC01_RS27410	COG0531	amino acid
CAC01_RS27415	COG1522	sequence-specific DNA binding
CAC01_RS27425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAC01_RS27445	COG2233	PERMEase
CAC01_RS27455	COG2223	nitrite transmembrane transporter activity
CAC01_RS27460	COG1940	carbohydrate kinase activity
CAC01_RS27460	COG1846	Transcriptional regulator
CAC01_RS27465	COG1595	DNA-templated transcription, initiation
CAC01_RS27480	COG3201	nicotinamide mononucleotide transporter
CAC01_RS27485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAC01_RS27485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAC01_RS27490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAC01_RS27495	COG0140	phosphoribosyl-ATP diphosphatase activity
CAC01_RS27500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CAC01_RS27515	COG1253	flavin adenine dinucleotide binding
CAC01_RS27535	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS27545	COG1522	sequence-specific DNA binding
CAC01_RS27555	COG1216	Glycosyl transferase, family 2
CAC01_RS27570	COG2270	Major facilitator Superfamily
CAC01_RS27575	COG0584	glycerophosphoryl diester phosphodiesterase
CAC01_RS27580	COG2364	Membrane
CAC01_RS27585	COG2186	Transcriptional regulator
CAC01_RS27650	COG2018	Roadblock/LC7 domain
CAC01_RS27670	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CAC01_RS27680	COG1501	Belongs to the glycosyl hydrolase 31 family
CAC01_RS27685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAC01_RS27695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAC01_RS27730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAC01_RS27750	COG1716	ATPase activity
CAC01_RS27770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAC01_RS27780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAC01_RS27780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAC01_RS27810	COG0137	argininosuccinate synthase activity
CAC01_RS27815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAC01_RS27850	COG0697	spore germination
CAC01_RS27890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAC01_RS27915	COG1940	carbohydrate kinase activity
CAC01_RS27940	COG1940	carbohydrate kinase activity
CAC01_RS27985	COG1968	undecaprenyl-diphosphatase activity
CAC01_RS28020	COG0110	maltose O-acetyltransferase activity
CAC01_RS28045	COG1832	CoA-binding protein
CAC01_RS28050	COG1739	Uncharacterized protein family UPF0029
CAC01_RS28085	COG1126	abc transporter atp-binding protein
CAC01_RS28100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS28105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS28115	COG0420	3'-5' exonuclease activity
CAC01_RS28120	COG0419	ATPase involved in DNA repair
CAC01_RS28125	COG1522	sequence-specific DNA binding
CAC01_RS28150	COG0515	serine threonine protein kinase
CAC01_RS28160	COG1132	(ABC) transporter
CAC01_RS28170	COG2197	response regulator
CAC01_RS28190	COG1309	transcriptional regulator
CAC01_RS28215	COG1846	Transcriptional regulator
CAC01_RS28225	COG2188	Transcriptional regulator
CAC01_RS28230	COG1940	carbohydrate kinase activity
CAC01_RS28235	COG2197	response regulator
CAC01_RS28240	COG4585	Histidine kinase
CAC01_RS28265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAC01_RS28280	COG1253	flavin adenine dinucleotide binding
CAC01_RS28305	COG0740	serine-type endopeptidase activity
CAC01_RS28315	COG0831	urea catabolic process
CAC01_RS28320	COG0832	Belongs to the urease beta subunit family
CAC01_RS28325	COG0804	urea catabolic process
CAC01_RS28330	COG0830	nickel cation binding
CAC01_RS28335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CAC01_RS28340	COG0829	nickel cation binding
CAC01_RS28375	COG0205	6-phosphofructokinase activity
CAC01_RS28380	COG3442	glutamine amidotransferase
CAC01_RS28390	COG0242	peptide deformylase activity
CAC01_RS28400	COG1960	acyl-CoA dehydrogenase activity
CAC01_RS28450	COG0254	rRNA binding
CAC01_RS28495	COG0519	Catalyzes the synthesis of GMP from XMP
CAC01_RS28555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAC01_RS28570	COG0475	glutathione-regulated potassium exporter activity
CAC01_RS28585	COG3851	Histidine kinase
CAC01_RS28590	COG2197	response regulator
CAC01_RS28595	COG0604	alcohol dehydrogenase
CAC01_RS28605	COG1846	Transcriptional regulator
CAC01_RS28610	COG2814	Major facilitator Superfamily
CAC01_RS28615	COG1191	sigma factor activity
CAC01_RS28640	COG0702	epimerase
CAC01_RS28645	COG2268	Band 7 protein
CAC01_RS28655	COG0386	Belongs to the glutathione peroxidase family
CAC01_RS28715	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CAC01_RS28720	COG4251	negative regulation of phosphorylation
CAC01_RS28725	COG0784	Response regulator, receiver
CAC01_RS28730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAC01_RS28735	COG1414	Transcriptional regulator
CAC01_RS28765	COG2814	Major facilitator Superfamily
CAC01_RS28790	COG1846	Transcriptional regulator
CAC01_RS28800	COG0596	Alpha beta hydrolase
CAC01_RS28800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAC01_RS28805	COG2409	Drug exporters of the RND superfamily
CAC01_RS28810	COG1309	transcriptional regulator
CAC01_RS28815	COG0456	acetyltransferase
CAC01_RS28815	COG0454	-acetyltransferase
CAC01_RS28820	COG0477	Major facilitator Superfamily
CAC01_RS28835	COG0435	Glutathione S-transferase
CAC01_RS28875	COG1309	transcriptional regulator
CAC01_RS28885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAC01_RS28900	COG2304	oxidoreductase activity
CAC01_RS28955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAC01_RS28965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAC01_RS28990	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAC01_RS29010	COG0395	ABC-type sugar transport system, permease component
CAC01_RS29015	COG1175	transmembrane transport
CAC01_RS29020	COG1653	transport
CAC01_RS29035	COG1414	Transcriptional regulator
CAC01_RS29040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAC01_RS29045	COG4948	Mandelate Racemase Muconate Lactonizing
CAC01_RS29055	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS29095	COG5297	Belongs to the glycosyl hydrolase family 6
CAC01_RS29105	COG3290	protein histidine kinase activity
CAC01_RS29115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAC01_RS29170	COG1674	ftsk spoiiie
CAC01_RS29170	COG0433	COG0433 Predicted ATPase
CAC01_RS29190	COG0395	ABC-type sugar transport system, permease component
CAC01_RS29195	COG1175	transmembrane transport
CAC01_RS29215	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CAC01_RS29245	COG2723	6-phospho-beta-galactosidase activity
CAC01_RS29250	COG5650	phosphatidylinositol metabolic process
CAC01_RS29275	COG0747	negative chemotaxis
CAC01_RS29295	COG2151	metal-sulfur cluster biosynthetic enzyme
CAC01_RS29300	COG3396	Phenylacetate-CoA oxygenase
CAC01_RS29305	COG3460	Phenylacetate-CoA oxygenase
CAC01_RS29310	COG3396	Phenylacetate-CoA oxygenase
CAC01_RS29315	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAC01_RS29320	COG1024	Enoyl-CoA hydratase
CAC01_RS29325	COG0183	Belongs to the thiolase family
CAC01_RS29335	COG2050	protein possibly involved in aromatic compounds catabolism
CAC01_RS29345	COG0438	transferase activity, transferring glycosyl groups
CAC01_RS29350	COG1012	belongs to the aldehyde dehydrogenase family
CAC01_RS29355	COG2326	polyphosphate kinase activity
CAC01_RS29360	COG0328	RNA-DNA hybrid ribonuclease activity
CAC01_RS29365	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS29405	COG0673	inositol 2-dehydrogenase activity
CAC01_RS29425	COG0456	acetyltransferase
CAC01_RS29440	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS29445	COG2111	Na H antiporter
CAC01_RS29445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAC01_RS29450	COG1006	Multisubunit Na H antiporter MnhC subunit
CAC01_RS29455	COG0651	ATP synthesis coupled electron transport
CAC01_RS29485	COG0673	inositol 2-dehydrogenase activity
CAC01_RS29490	COG1940	carbohydrate kinase activity
CAC01_RS29490	COG1846	Transcriptional regulator
CAC01_RS29500	COG1175	transmembrane transport
CAC01_RS29505	COG0395	ABC-type sugar transport system, permease component
CAC01_RS29530	COG2188	Transcriptional regulator
CAC01_RS29540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CAC01_RS29575	COG0477	Major facilitator Superfamily
CAC01_RS29595	COG1764	response to oxidative stress
CAC01_RS29600	COG1846	Transcriptional regulator
CAC01_RS29630	COG1132	(ABC) transporter
CAC01_RS29635	COG0673	inositol 2-dehydrogenase activity
CAC01_RS29640	COG1309	transcriptional regulator
CAC01_RS29665	COG1175	transmembrane transport
CAC01_RS29670	COG0395	ABC-type sugar transport system, permease component
CAC01_RS29675	COG0366	Alpha amylase catalytic
CAC01_RS29715	COG1285	pathogenesis
CAC01_RS29735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAC01_RS29765	COG3383	formate dehydrogenase (NAD+) activity
CAC01_RS29765	COG0243	molybdopterin cofactor binding
CAC01_RS29770	COG0437	4 iron, 4 sulfur cluster binding
CAC01_RS29785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAC01_RS29810	COG2391	methyltransferase activity
CAC01_RS29815	COG0656	L-ascorbic acid biosynthetic process
CAC01_RS29845	COG2226	methyltransferase
CAC01_RS29855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAC01_RS29880	COG0667	Aldo Keto reductase
CAC01_RS29885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAC01_RS29905	COG3387	PFAM Glycoside hydrolase 15-related
CAC01_RS29915	COG0542	response to heat
CAC01_RS29920	COG3896	Chloramphenicol phosphotransferase-like protein
CAC01_RS29950	COG0747	negative chemotaxis
CAC01_RS29960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAC01_RS29965	COG0444	Belongs to the ABC transporter superfamily
CAC01_RS30010	COG1414	Transcriptional regulator
CAC01_RS30045	COG3842	ATPase activity
CAC01_RS30050	COG0395	ABC-type sugar transport system, permease component
CAC01_RS30090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAC01_RS30100	COG0698	ribose 5-phosphate isomerase
CAC01_RS30115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAC01_RS30120	COG2159	amidohydrolase
CAC01_RS30145	COG0183	Belongs to the thiolase family
CAC01_RS30150	COG3485	protocatechuate 3,4-dioxygenase
CAC01_RS30165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAC01_RS30215	COG1472	Belongs to the glycosyl hydrolase 3 family
CAC01_RS30220	COG2188	Transcriptional regulator
CAC01_RS30225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CAC01_RS30235	COG1280	lysine exporter protein (LysE YggA)
CAC01_RS30255	COG1028	Short-chain dehydrogenase reductase Sdr
CAC01_RS30260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAC01_RS30285	COG2175	clavaminate synthase activity
CAC01_RS30300	COG1349	DNA-binding transcription factor activity
CAC01_RS30305	COG2356	endonuclease I
CAC01_RS30350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAC01_RS30485	COG1196	nuclear chromosome segregation
CAC01_RS30525	COG1196	nuclear chromosome segregation
CAC01_RS30695	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CAC01_RS30795	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CAC01_RS30860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAC01_RS30910	COG1793	dna ligase
CAC01_RS30985	COG2186	Transcriptional regulator
CAC01_RS31080	COG1660	Displays ATPase and GTPase activities
CAC01_RS31125	COG1051	belongs to the nudix hydrolase family
CAC01_RS31135	COG1192	Involved in chromosome partitioning
CAC01_RS31230	COG1196	nuclear chromosome segregation